Science.gov

Sample records for high luminosity insertion

  1. The High Luminosity LHC Project

    NASA Astrophysics Data System (ADS)

    Rossi, Lucio

    The High Luminosity LHC is one of the major scientific project of the next decade. It aims at increasing the luminosity reach of LHC by a factor five for peak luminosity and a factor ten in integrated luminosity. The project, now fully approved and funded, will be finished in ten years and will prolong the life of LHC until 2035-2040. It implies deep modifications of the LHC for about 1.2 km around the high luminosity insertions of ATLAS and CMS and relies on new cutting edge technologies. We are developing new advanced superconducting magnets capable of reaching 12 T field; superconducting RF crab cavities capable to rotate the beams with great accuracy; 100 kA and hundred meter long superconducting links for removing the power converter out of the tunnel; new collimator concepts, etc... Beside the important physics goals, the High Luminosity LHC project is an ideal test bed for new technologies for the next hadron collider for the post-LHC era.

  2. SDC at high luminosity

    SciTech Connect

    Green, D.

    1990-05-01

    Why is it prudent to plan for a luminosity (L) of >10{sup 34}/(cm{sup 2}sec) from the beginning First, the SSC is easily capable of attaining high luminosity. In comparison, for {bar p}p machines such as the Tevatron, increases in L are difficult. Second, after early runs at design luminosity, the only simple upgrade to a general purpose detector is an increase in luminosity. Third, and most important, the only known model independent physics goal of SSC is in the electroweak sector; the ZZ scattering amplitude reaches the unitarity bound for {radical}{cflx s} {approx equal} 3 TeV. In order to reach this mass range, and assure that some new physics is found, high luminosity running is needed. Since high luminosity running is desirable and easily attainable, it is inevitable. Therefore, one should build the hooks'' for upgrades to high L into the SDC from the beginning. The experience of CDF is that if this is not done, upgrades can be painful. Specifically, if possible, SDC should make sure that the chosen technologies allow high L operation. The time to plan for the whole useful lifetime of SDC is from the beginning. 9 refs., 6 figs.

  3. High luminosity particle colliders

    SciTech Connect

    Palmer, R.B.; Gallardo, J.C.

    1997-03-01

    The authors consider the high energy physics advantages, disadvantages and luminosity requirements of hadron (pp, p{anti p}), lepton (e{sup +}e{sup {minus}}, {mu}{sup +}{mu}{sup {minus}}) and photon-photon colliders. Technical problems in obtaining increased energy in each type of machine are presented. The machines relative size are also discussed.

  4. Mini-. beta. insertion and luminosity for the RHIC lattice

    SciTech Connect

    Lee, S.Y.; Dell, G.F.; Hahn, H.; Parzen, G.; Ruggiero, A.G.

    1989-01-01

    Requirement and implication of the mini-..beta.. insertion, where a pair of common quadrupoles are inserted between the interaction point and the frist beam crossing dipole, in RHIC lattice is studied. For the heavy ion operation, we find that ..beta.. = 1m can be achieved with a +-5m free space for experimental setup and /cflx /beta// = 500m. The beam size limitation is located at the second beam crossing dipole BC2, where 8cm coil i.d. is considered. When the machine is operating at the proton-heavy ion collision mode, these common quadrupoles should be removed physically in order to let both beams crossing the center line at 3.4 mrad. These mini-..beta.. insertion can increase the luminosity by a factor of 2 /approximately/ 3. For the proton-proton collision mode, we find that ..beta.. = 0.5m is also operable without the mini-..beta.. quadrupoles due to smaller emittance for the proton beam. The corresponding /cflx /beta// is 2400m. When the mini-..beta.. quads are used, ..beta.. = 0.25m can be achieved. The ultimate luminosity for the proton-proton collision is of the order of 10/sup 33//cm/sup 2/ sec, which may be useful in the quest of the B physics studies. 3 refs., 3 figs., 3 tabs.

  5. Linear Colliders: Achieving High Luminosity

    NASA Astrophysics Data System (ADS)

    Dugan, Gerald

    2002-04-01

    Four styles of linear collider are under active consideration by the high energy physics community as candidates for the next machine at the energy frontier. The four concepts (CLIC, the C-band linear collider, NLC/JLC and TESLA) differ widely in technology but share similar goals for energy and luminosity. The luminosity goal is more than three orders of magntiude larger than what has been acheived at the SLC. Nevertheless, as a result of many years of world-wide accelerator R&D efforts, feasible designs now exist for machines capable of reaching this goal. This talk will review the methods proposed by each linear collider concept to attain its luminosity goal. The most challenging issues facing each concept will be outlined and compared, and the areas requiring further R&D efforts will be noted.

  6. Dijet spectroscopy at high luminosity

    SciTech Connect

    Green, D.

    1990-07-01

    A study of the dijet mass resolution has been made appropriate to high luminosity operation. As a benchmark, the mass resolution of W {yields} jj for a Higgs boson of 800 GeV has been optimized for no, eight, and sixteen overlapping minbias events. A factor of 2.5 degradation in M{sub jj} width is seen. 6 refs., 10 figs.

  7. High Speed Video Insertion

    NASA Astrophysics Data System (ADS)

    Janess, Don C.

    1984-11-01

    This paper describes a means of inserting alphanumeric characters and graphics into a high speed video signal and locking that signal to an IRIG B time code. A model V-91 IRIG processor, developed by Instrumentation Technology Systems under contract to Instrumentation Marketing Corporation has been designed to operate in conjunction with the NAC model FHS-200 High Speed Video Camera which operates at 200 fields per second. The system provides for synchronizing the vertical and horizontal drive signals such that the vertical sync precisely coincides with five millisecond transitions in the IRIG time code. Additionally, the unit allows for the insertion of an IRIG time message as well as other data and symbols.

  8. High Luminosity LHC: challenges and plans

    NASA Astrophysics Data System (ADS)

    Arduini, G.; Barranco, J.; Bertarelli, A.; Biancacci, N.; Bruce, R.; Brüning, O.; Buffat, X.; Cai, Y.; Carver, L. R.; Fartoukh, S.; Giovannozzi, M.; Iadarola, G.; Li, K.; Lechner, A.; Medina Medrano, L.; Métral, E.; Nosochkov, Y.; Papaphilippou, Y.; Pellegrini, D.; Pieloni, T.; Qiang, J.; Redaelli, S.; Romano, A.; Rossi, L.; Rumolo, G.; Salvant, B.; Schenk, M.; Tambasco, C.; Tomás, R.; Valishev, S.; Van der Veken, F. F.

    2016-12-01

    The Large Hadron Collider (LHC) is one of the largest scientific instruments ever built. Since opening up a new energy frontier for exploration in 2010, it has gathered a global user community working in fundamental particle physics and the physics of hadronic matter at extreme temperature and density. To sustain and extend its discovery potential, the LHC will undergo a major upgrade in the 2020s. This will increase its rate of collisions by a factor of five beyond the original design value and the integrated luminosity by a factor ten. The new configuration, known as High Luminosity LHC (HL-LHC), will rely on a number of key innovations that push accelerator technology beyond its present limits. Among these are cutting-edge 11-12 T superconducting magnets, including Nb3Sn-based magnets never used in accelerators before, compact superconducting cavities for longitudinal beam rotation, new technology and physical processes for beam collimation. The dynamics of the HL-LHC beams will be also particularly challenging and this aspect is the main focus of this paper.

  9. High Luminosity LHC: Challenges and plans

    DOE PAGES

    Arduini, G.; Barranco, J.; Bertarelli, A.; ...

    2016-12-28

    The Large Hadron Collider (LHC) is one of the largest scientific instruments ever built. Since opening up a new energy frontier for exploration in 2010, it has gathered a global user community working in fundamental particle physics and the physics of hadronic matter at extreme temperature and density. To sustain and extend its discovery potential, the LHC will undergo a major upgrade in the 2020s. This will increase its rate of collisions by a factor of five beyond the original design value and the integrated luminosity by a factor ten. The new configuration, known as High Luminosity LHC (HL-LHC), willmore » rely on a number of key innovations that push accelerator technology beyond its present limits. Among these are cutting-edge 11–12 T superconducting magnets, including Nb3Sn-based magnets never used in accelerators before, compact superconducting cavities for longitudinal beam rotation, new technology and physical processes for beam collimation. As a result, the dynamics of the HL-LHC beams will be also particularly challenging and this aspect is the main focus of this paper.« less

  10. High Luminosity LHC: Challenges and plans

    SciTech Connect

    Arduini, G.; Barranco, J.; Bertarelli, A.; Biancacci, N.; Bruce, R.; Bruning, O.; Buffat, X.; Cai, Y.; Carver, L. R.; Fartoukh, S.; Giovannozzi, Massimo; Iadarola, G.; Li, K.; Lechner, A.; Medrano, L. Medina; Metral, E.; Nosochkov, Y.; Papaphilippou, Y.; Pellegrini, D.; Pieloni, T.; Qiang, J.; Redaelli, S.; Romano, A.; Rossi, L.; Rumolo, G.; Salvant, B.; Schenk, M.; Tambasco, C.; Tomas, R.; Valishev, S.; Van der Veken, F. F.

    2016-12-28

    The Large Hadron Collider (LHC) is one of the largest scientific instruments ever built. Since opening up a new energy frontier for exploration in 2010, it has gathered a global user community working in fundamental particle physics and the physics of hadronic matter at extreme temperature and density. To sustain and extend its discovery potential, the LHC will undergo a major upgrade in the 2020s. This will increase its rate of collisions by a factor of five beyond the original design value and the integrated luminosity by a factor ten. The new configuration, known as High Luminosity LHC (HL-LHC), will rely on a number of key innovations that push accelerator technology beyond its present limits. Among these are cutting-edge 11–12 T superconducting magnets, including Nb3Sn-based magnets never used in accelerators before, compact superconducting cavities for longitudinal beam rotation, new technology and physical processes for beam collimation. As a result, the dynamics of the HL-LHC beams will be also particularly challenging and this aspect is the main focus of this paper.

  11. Results From the DAFNE High Luminosity Test

    SciTech Connect

    Milardi, C.; Alesini, D.; Biagini, M.E.; Boni, R.; Boscolo, M.; Bossi, F.; Buonomo, B.; Clozza, A.; Delle Monache, G.; Demma, T.; Di Pasquale, E.; Di Pirro, G.; Drago, A.; Gallo, A.; Ghigo, A.; Guiducci, S.; Ligi, C.; Marcellini, F.; Mazzitelli, G.; Murtas, F.; Pellegrino, L.; /Frascati /Novosibirsk, IYF /CERN /INFN, Cosenza /INFN, Rome /KEK, Tsukuba /Orsay, LAL /Rome U. /Pisa U. /INFN, Pisa /INFN, Rome3 /SLAC

    2012-04-11

    The DAPHNE collider, based on a new collision scheme including Large Piwinsky angle and Crab-Waist, has been successfully commissioned and is presently delivering luminosity to the SIDDHARTA detector. Large crossing angle and Crab-Waist scheme proved to be effective in: (1) Increasing luminosity, now a factor 2.7 higher than in the past; and (2) controlling transverse beam blow-up due to the beam-beam. Work is in progress to reach the ultimate design luminosity goal 5.0 {center_dot} 10{sup 32} cm{sup -2}s{sup -1}. The new collision scheme is the main design concept for a new project aimed at building a Super-B factory that is expected to achieve a luminosity of the order of 10{sup 36} cm{sup -2} s{sup -1} and it has been also taken into account to upgrade one of the LHC interaction regions.

  12. The high luminosity interaction region for a ring-ring Large Hadron Electron Collider

    NASA Astrophysics Data System (ADS)

    Appleby, R. B.; Thompson, L.; Holzer, B.; Fitterer, M.; Bernard, N.; Kostka, P.

    2013-12-01

    The Large Hadron Electron Collider (LHeC) project is a proposal for high luminosity TeV-scale electron-proton (ep) collisions at the LHC. The LHeC Conceptual Design Report presented an early overview of the machine, including an electron linac solution and a solution involving a 60 GeV electron storage ring. Here we present a new complete solution for the collision insertion of this electron ring, incorporating all constraints including those imposed by the LHC and, for the first time, proving the feasibility of ep collisions at a luminosity of ˜1033 cm-2s-1 in the LHC era. The solution presented offers high luminosity while maintaining the large detector coverage required by the particle physics programme. This negates the earlier need for two separate interaction region designs, one optimized for high luminosity at the cost of detector coverage, and the other for lower luminosity but higher coverage. Synchrotron radiation emission is also a major factor in electron accelerator design, and studies are presented showing the feasibility of the design in this regard. The design is found to be technically viable, solving the problem of TeV-scale, high luminosity and high coverage ep collisions at a ring-ring LHeC.

  13. High-field Magnet Development toward the High Luminosity LHC

    SciTech Connect

    Apollinari, Giorgio

    2014-07-01

    The upcoming Luminosity upgrade of the LHC (HL-LHC) will rely on the use of Accelerator Quality Nb3Sn Magnets which have been the focus of an intense R&D effort in the last decade. This contribution will describe the R&D and results of Nb3Sn Accelerator Quality High Field Magnets development efforts, with emphasis on the activities considered for the HL-LHC upgrades.

  14. Producing ultra high energy cosmic rays from AGN magnetic luminosity

    NASA Astrophysics Data System (ADS)

    Coimbra-Araújo, Carlos H.; Anjos, Rita C.

    The present work proposes a method to calculate the AGN magnetic luminosity fraction to be converted into ultra high energy cosmic rays (UHECRs) luminosities for nine UHECR AGN Seyfert sources based on the respective observation of gamma ray upper limits. The motivation for such calculation comes attached to the fact that a fraction of the magnetic luminosity (L B ) produced by Kerr black holes in some AGNs can produce the necessary energy to accelerate UHECRs beyond the GZK limit, observed, e.g., by the Auger experiment. Nevertheless, the direct detection of those UHECRs has a lack of information about the direction of the source from where those cosmic rays are coming, since charged particles are deflected by the intergalactic magnetic field. Such problem arises alternative methods to evaluate the luminosity of UHECRs from the observation of upper limits during the propagation.

  15. Simulation of the LHC BRAN luminosity monitor for high luminosity interaction regions

    SciTech Connect

    Miyamoto, R.; Matis, H.; Ratti, A.; Stiller, J.; White, S.M.

    2010-05-23

    The BRAN (Beam RAte of Neutrals) detector monitors the collision rates in the high luminosity interaction regions of LHC (ATLAS and CMS). This Argon gas ionization detector measures the forward neutral particles from collisions at the interaction point. To predict and improve the understanding of the detector's performance, we produced a detailed model of the detector and its surroundings in Fluka. In this paper, we present the model and results of our simulations including the detectors estimated response to interactions for beam energies of 3.5, 5, and 7 TeV.

  16. Triggering at a high luminosity hadron collider

    SciTech Connect

    Price, L.E.; Wagner, R.G.; Abolins, M.A.

    1984-01-01

    The extreme interaction rate occurring at the SSC as described in the Reference Design Report poses the principal new challenge for the triggering system compared with detectors at previous accelerators. At SSC we must plan for about 10/sup 8/ interactions per second. If bunch crossings occur each 33 ns, there will be an average of 3 interactions in each bunch crossing. Potential problems for triggering are presented both by the high total rate and by the multiple interactions per bunch crossing, so that triggering events must be selected in the presence of other interactions independent of the inherent speed of either detector elements or triggering electronics. Three principal topics are considered in this report: (1) Practical selections to be made in a first-level trigger to reduce the rate by a factor of 1000. (2) Electronics expected to implement this first-level trigger, and (3) the ultimate trigger selections that must be used to select the approximately 1 Hz that can practically be recorded for detailed analysis. 11 references, 6 figures.

  17. High-Pressure Trocar Insertion Technique

    PubMed Central

    Reich, Harry; Conti Ribeiro, Sergio; Rasmussen, Carsten; Rosenberg, Jay

    1999-01-01

    Background: The majority of laparoscopic complications occur at the time of Veress needle and trocar insertion. Although not very frequent, they increase the morbidity and mortality of both diagnostic and operative laparoscopic procedures. Alternative techniques of trocar insertion have been described but have not completely eliminated the risk of injury. Technique: After Veress needle insertion and establishment of pneumoperitoneum to 25 to 30 mm Hg, insertion of a short trocar is performed in the deepest part of the umbilicus without elevation of the anterior abdominal wall. The result is a parietal peritoneal puncture directly beneath the umbilicus. The high-pressure setting used during initial insertion of the trocar is lowered as soon as safe abdominal entry is documented. Experience: The trocar insertion technique described above was performed in 3041 procedures. No vascular injury occurred. There were two bowel perforations. No complications related to the increased intra-abdominal pressure were observed. Conclusion: The high-pressure abdominal entry technique has the advantage of reducing intra-abdominal trocar-related injuries without requiring additional instrumentation or additional training. PMID:10323169

  18. Accretion disk coronae in high-luminosity systems

    NASA Technical Reports Server (NTRS)

    Murray, Stephen D.; Castor, John I.; Klein, Richard I.; Mckee, Christopher F.

    1994-01-01

    We present the results of self-consistent models of Compton-heated accretion disk coronae. The models are calculated using a new method for computing monochromatic radiative transfer n two dimensions. The method splits the radiation into direct and scattered components. The direct radiation is computed by calculating the optical depth along rays, while transfer of the scattered radiation is approximated by flux-limited diffusion. The resulting code agrees with more accurate treatments to within 50%, and is highly efficient, making it practical for use in large hydrodynamic simulations. The coronal models are used to confirm the results of earlier work, and to extend it to higher luminosities. In contrast to earlier work, which found the outer disks to be shadowed by the inner corona at high luminosities, we find our results to form an almost continuous extension of the models at lower luminosities. This is due to the presence of multiply scattered radiation, which acts to partially offset the loss of direct radiation from the central source. Although the analytic methods derived at lower luminosities cannot be used to derive the coronal structure for L/L(sub Edd) approx. greater than 0.1, the results of the models are amenable to semiempirical fits. We also discuss possible observational consequences of the results for coronal veiling and line fluorescence from the disk.

  19. Accretion disk coronae in high-luminosity systems

    NASA Technical Reports Server (NTRS)

    Murray, Stephen D.; Castor, John I.; Klein, Richard I.; Mckee, Christopher F.

    1994-01-01

    We present the results of self-consistent models of Compton-heated accretion disk coronae. The models are calculated using a new method for computing monochromatic radiative transfer n two dimensions. The method splits the radiation into direct and scattered components. The direct radiation is computed by calculating the optical depth along rays, while transfer of the scattered radiation is approximated by flux-limited diffusion. The resulting code agrees with more accurate treatments to within 50%, and is highly efficient, making it practical for use in large hydrodynamic simulations. The coronal models are used to confirm the results of earlier work, and to extend it to higher luminosities. In contrast to earlier work, which found the outer disks to be shadowed by the inner corona at high luminosities, we find our results to form an almost continuous extension of the models at lower luminosities. This is due to the presence of multiply scattered radiation, which acts to partially offset the loss of direct radiation from the central source. Although the analytic methods derived at lower luminosities cannot be used to derive the coronal structure for L/L(sub Edd) approx. greater than 0.1, the results of the models are amenable to semiempirical fits. We also discuss possible observational consequences of the results for coronal veiling and line fluorescence from the disk.

  20. Physics of a high-luminosity Tau-Charm Factory

    SciTech Connect

    King, M.E.

    1992-10-01

    This paper highlights the physics capabilities of a Tau-Charm Factory; i.e., high luminosity ({approximately}10{sup 33}cm{sup {minus}2}s{sup {minus}1}) e{sup +}e{sup {minus}} collider operating in the center-of-mass energy range of 3-5 GeV, with a high-precision, general-purpose detector. Recent developments in {tau} and charm physics are emphasized.

  1. 4D fast tracking for experiments at high luminosity LHC

    NASA Astrophysics Data System (ADS)

    Neri, N.; Cardini, A.; Calabrese, R.; Fiorini, M.; Luppi, E.; Marconi, U.; Petruzzo, M.

    2016-11-01

    The full exploitation of the physics potential of the high luminosity LHC is a big challenge that requires new instrumentation and innovative solutions. We present here a conceptual design and simulation studies of a fast timing pixel detector with embedded real-time tracking capabilities. The system is conceived to operate at 40 MHz event rate and to reconstruct tracks in real-time, using precise space and time 4D information of the hit, for fast trigger decisions. This work is part of an R&D project aimed at building an innovative tracking detector with superior time (10 ps) and position (10 μm) resolutions to be used in very harsh radiation environments, for the ultimate flavour physics experiment at the high luminosity phase of the LHC.

  2. OH megamasers in high-luminosity IRAS galaxies

    NASA Technical Reports Server (NTRS)

    Mirabel, I. F.; Sanders, D. B.

    1987-01-01

    OH megamaser emission and H I and CO profiles from the distant infrared galaxies IRAS 10173 + 0828, III Zw 035, and Zw 475.056 are reported. The OH isotropic luminosities at 1667 MHz are 463, 534, and 6.6 solar luminosities, respectively. Far-infrared pumping efficiencies of the OH greater than 1 percent are found in IRAS 10173 + 0828 and III Zw 035. These two galaxies show anomalously large 1667/1665 MHz emission line ratios. OH megamasers reside in the nuclei of superluminous far-infrared galaxies that have a high content of molecular gas, high efficiency of star formation, and in some instances, a striking deficiency of atomic hydrogen.

  3. High Speed Measurements of the LHC Luminosity Monitor

    NASA Astrophysics Data System (ADS)

    Beche, J. F.; Byrd, J. M.; Monroy, M.; Ratti, A.; Turner, W.; Bravin, E.

    2006-11-01

    The LHC luminosity monitor is a gas ionization chamber designed to operate in the high radiation environment present in the TAN neutral absorbers at the LHC. One of the challenges is to measure the luminosity of individual bunch crossings with a minimum separation of 25 nsec. To test the time response and other aspects of a prototype chamber, we have performed a test using an x-ray beam of 40-60 keV with pulse spacing of 26 nsec as an ionizing beam. The tests were made at BL 8.3.2 at the Advanced Light Source (ALS). This work was supported by the Director, Office of Science, Office of High Energy Physics, of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231.

  4. OH megamasers in high-luminosity IRAS galaxies

    NASA Technical Reports Server (NTRS)

    Mirabel, I. F.; Sanders, D. B.

    1987-01-01

    OH megamaser emission and H I and CO profiles from the distant infrared galaxies IRAS 10173 + 0828, III Zw 035, and Zw 475.056 are reported. The OH isotropic luminosities at 1667 MHz are 463, 534, and 6.6 solar luminosities, respectively. Far-infrared pumping efficiencies of the OH greater than 1 percent are found in IRAS 10173 + 0828 and III Zw 035. These two galaxies show anomalously large 1667/1665 MHz emission line ratios. OH megamasers reside in the nuclei of superluminous far-infrared galaxies that have a high content of molecular gas, high efficiency of star formation, and in some instances, a striking deficiency of atomic hydrogen.

  5. Dynamic aperture studies for the LHC high luminosity lattice

    SciTech Connect

    Maria, R. de; Giovannozzi, M.; McIntosh, E.; Nosochkov, Y. M.; Cai, Y.; Wang, M. -H.

    2015-07-14

    Since quite some time, dynamic aperture studies have been undertaken with the aim of specifying the required field quality of the new magnets that will be installed in the LHC ring in the framework of the high-luminosity upgrade. In this paper the latest results concerning the specification work will be presented, taking into account both injection and collision energies and the field quality contribution from all the magnets in the newly designed interaction regions.

  6. IUE observations of blue halo high luminosity stars

    NASA Technical Reports Server (NTRS)

    Hack, M.; Franco, M. L.; Stalio, R.

    1981-01-01

    Two high luminosity population II blue stars of high galactic latitude, BD+33 deg 2642 and HD 137569 were observed at high resolution. The stellar spectra show the effect of mass loss in BD+33 deg 2642 and abnormally weak metallic lines in HD 137569. The interstellar lines in the direction of BD+33 deg 2642, which lies at a height z greater than or equal to 6.2 kpc from the galactic plane, are split into two components. No high ionization stages are found at the low velocity component; nor can they be detected in the higher velocity clouds because of mixing with the corresponding stellar/circumstellar lines.

  7. SLHC, the High-Luminosity Upgrade (public event)

    ScienceCinema

    None

    2016-07-12

    In the morning of June 23rd a public event is organised in CERN's Council Chamber with the aim of providing the particle physics community with up-to-date information about the strategy for the LHC luminosity upgrade and to describe the current status of preparation work. The presentations will provide an overview of the various accelerator sub-projects, the LHC physics prospects and the upgrade plans of ATLAS and CMS. This event is organised in the framework of the SLHC-PP project, which receives funding from the European Commission for the preparatory phase of the LHC High Luminosity Upgrade project. Informing the public is among the objectives of this EU-funded project. A simultaneous transmission of this meeting will be broadcast, available at the following address: http://webcast.cern.ch/

  8. High luminosity electron-hadron collider eRHIC

    SciTech Connect

    Ptitsyn, V.; Aschenauer, E.; Bai, M.; Beebe-Wang, J.; Belomestnykh, S.; Ben-Zvi, I.; Blaskiewicz, M..; Calaga, R.; Chang, X.; Fedotov, A.; Gassner, D.; Hammons, L.; Hahn, H.; Hammons, L.; He, P.; Hao, Y.; Jackson, W.; Jain, A.; Johnson, E.C.; Kayran, D.; Kewisch, J.; Litvinenko, V.N.; Luo, Y.; Mahler, G.; McIntyre, G.; Meng, W.; Minty, M.; Parker, B.; Pikin, A.; Rao, T.; Roser, T.; Skaritka, J.; Sheehy, B.; Skaritka, J.; Tepikian, S.; Than, Y.; Trbojevic, D.; Tsoupas, N.; Tuozzolo, J.; Wang, G.; Webb, S.; Wu, Q.; Xu, W.; Pozdeyev, E.; Tsentalovich, E.

    2011-03-28

    We present the design of a future high-energy high-luminosity electron-hadron collider at RHIC called eRHIC. We plan on adding 20 (potentially 30) GeV energy recovery linacs to accelerate and to collide polarized and unpolarized electrons with hadrons in RHIC. The center-of-mass energy of eRHIC will range from 30 to 200 GeV. The luminosity exceeding 10{sup 34} cm{sup -2} s{sup -1} can be achieved in eRHIC using the low-beta interaction region with a 10 mrad crab crossing. We report on the progress of important eRHIC R&D such as the high-current polarized electron source, the coherent electron cooling, ERL test facility and the compact magnets for recirculation passes. A natural staging scenario of step-by-step increases of the electron beam energy by building-up of eRHIC's SRF linacs is presented.

  9. Silicon sensors for trackers at high-luminosity environment

    NASA Astrophysics Data System (ADS)

    Peltola, Timo

    2015-10-01

    The planned upgrade of the LHC accelerator at CERN, namely the high luminosity (HL) phase of the LHC (HL-LHC foreseen for 2023), will result in a more intense radiation environment than the present tracking system that was designed for. The required upgrade of the all-silicon central trackers at the ALICE, ATLAS, CMS and LHCb experiments will include higher granularity and radiation hard sensors. The radiation hardness of the new sensors must be roughly an order of magnitude higher than in the current LHC detectors. To address this, a massive R&D program is underway within the CERN RD50 Collaboration "Development of Radiation Hard Semiconductor Devices for Very High Luminosity Colliders" to develop silicon sensors with sufficient radiation tolerance. Research topics include the improvement of the intrinsic radiation tolerance of the sensor material and novel detector designs with benefits like reduced trapping probability (thinned and 3D sensors), maximized sensitive area (active edge sensors) and enhanced charge carrier generation (sensors with intrinsic gain). A review of the recent results from both measurements and TCAD simulations of several detector technologies and silicon materials at radiation levels expected for HL-LHC will be presented.

  10. GRO J1655-40 enters a highly-variable, high-luminosity state

    NASA Astrophysics Data System (ADS)

    Homan, Jeroen; Miller, Jon M.; Wijnands, Rudy; Lewin, Walter H. G.

    2005-05-01

    GRO J1655-40 enters a highly-variable, high-luminosity state Jeroen Homan (MIT), Jon M. Miller (CfA), Rudy Wijnands (U. of Amsterdam), and Walter H.G. Lewin (MIT) Recent RXTE observations of the black hole X-ray transient GRO J1655-40, which is currently in outburst (e.g. ATEL #414,#417,#418,#419,#432,#438), show that the source has entered a highly variable, high-luminosity state. During the past two months the source has been steadily increasing in luminosity, while remaining spectrally soft.

  11. CMS HCAL Endcap Simulations for the High Luminosity LHC

    NASA Astrophysics Data System (ADS)

    Pedro, Kevin

    2013-04-01

    The long-term high luminosity upgrade to the LHC will increase the levels of radiation affecting the CMS calorimeters. By the end of Phase 2, parts of the electromagnetic and hadronic endcap calorimeters could receive up to 10 MRad of radiation. A model of the radiation damage to HCAL, which has been implemented in the CMS fast simulation, will be described. The effects of radiation on physics capabilities with jets will be presented, with the most important effect coming from scaling of photodetector noise due to recalibration. In addition, a standalone Geant4 simulation with a simplified geometry can be used to test configurations with new radiation-hard ECALs. Results for pion response and resolution with new configurations will be shown.

  12. Red and Blue Shifted Broad Lines in High Luminosity QSOs

    NASA Astrophysics Data System (ADS)

    McIntosh, D. H.; Rieke, M. J.; Rix, H.-W.; Foltz, C. B.; Weymann, R. J.; Chaffee, F. H.

    1998-05-01

    We have observed a sample of 25 high luminosity QSOs, in the range 2.0 ≲ z ≲ 2.5, at 1.6micron with the near-infrared spectrograph FSPEC on the Multiple Mirror Telescope. We have measured the systemic redshift z_sys by direct detection of the strong [O 3]lambda5007 line emitted from the narrow-line-region. We have found that the broad Hβ lines, from the same spectra, have a systematic mean red shift of 530+/-80 km s(-1) with respect to systemic. From data in the literature, we have found that the high ionization, rest-frame ultraviolet broad lines C 4lambda1549 and Lyalpha are systematically blue shifted ~ 1500 km s(-1) and ~ 1000 km s(-1) , respectively, from systemic. Therefore, estimating the ionizing flux from the inter-galactic-medium J_ν() IGM via the Proximity Effect, using redshift measurements from these two broad line species, results in an over-estimation of J_ν() IGM by factors of 2.5-4.0. Furthermore, related calculations of the lower limit for the density of baryons Omega_b will be over-estimated by factors of 1.6-2.0. However, the low ionization broad line Mg 2lambda2798 is within 100 km s(-1) of systemic, and thus would be the line of choice for determining the true redshift of distant (z>1) QSOs without near-infrared spectroscopy.

  13. The winds of high luminosity late-type bright stars

    NASA Technical Reports Server (NTRS)

    Stencel, Robert E.; Carpenter, K. G.

    1989-01-01

    The occurrence and characteristics of the Fe II line asymmetries were studied to determine the radial dependence of the wind velocity for each star. The dependence of the Fe II profiles on spectral type and luminosity class and thus the variation of the velocity fields with stellar type was also investigated. This allows the generality of the results reported for alpha Ori by Carpenter (1984b) to be judged. In addition, new atomic data was used along with observations of the C II (UV 0.01) multiplet to estimate N(sub e) in the stellar winds. Measures of relative Fe II fluxes can be used in a probability-of-escape model to determine the opacity and hydrogen column density versus height in the chromosphere of each star. Finally, analysis of the fluorescent Fe II lines (pumped by Ly alpha) near 2507 A will yield estimates of the intrinsic stellar Ly alpha flux that cannot be measured directly because of interstellar and circumstellar absorption. One important goal of the effort was to acquire high resolution spectra of the whole 2300 to 3200 A region of 13 luminous K and M stars as a data base that will be enormously valuable in planning observations with the Hubble Space Telescope High Resolution Spectrograph. It is also proposed to follow up the recent discovery of significant variations in the Fe II chromospheric emission line profiles from the M-giant Gamma Cru for the purpose of determining the underlying cause of the variations.

  14. High Luminosity 100 TeV Proton-Antiproton Collider

    SciTech Connect

    Oliveros, S. J.; Acosta, J. G.; Cremaldi, L. M.; Hart, T. L.; Summers, D. J.

    2016-10-01

    The energy scale for new physics is known to be in the multi-TeV range, signaling the potential need for a collider beyond the LHC. A $10^{34}$ cm$^{-2}$ s$^{-1}$ luminosity 100 TeV proton-antiproton collider is explored. Prior engineering studies for 233 and 270 km circumference tunnels were done for Illinois dolomite and Texas chalk signaling manageable tunneling costs. At a $p\\bar{p}$ the cross section for high mass states is of order 10x higher with antiproton collisions, where antiquarks are directly present rather than relying on gluon splitting. The higher cross sections reduce the synchrotron radiation in superconducting magnets, because lower beam currents can produce the same rare event rates. In our design the increased momentum acceptance (11 $\\pm$ 2.6 GeV/c) in a Fermilab-like antiproton source is used with septa to collect 12x more antiprotons in 12 channels. For stochastic cooling, 12 cooling systems would be used, each with one debuncher/momentum equalizer ring and two accumulator rings. One electron cooling ring would follow. Finally antiprotons would be recycled during runs without leaving the collider ring, by joining them to new bunches with synchrotron damping.

  15. SuperB: a Linear High-Luminosity B Factory

    SciTech Connect

    Albert, J.; Bettarini, S.; Biagini, M.; Bonneaud, G.; Cai, Y.; Calderini, G.; Ciuchini, M.; Dubois-Felsmann, G.P.; Ecklund, S.; Forti, F.; Gershon, T.J.; Giorgi, M.A.; Hitlin, D.G.; Leith, D.W.G.S.; Lusiani, A.; MacFarlane, D.B.; Martinez-Vidal, F.; Neri, N.; Novokhatski, A.; Pierini, M.; Piredda, G.; /Caltech /Pisa U. /Pisa, Scuola Normale Superiore /INFN, Pisa /Frascati /Ecole Polytechnique /SLAC /Rome III U. /INFN, Rome3 /Warwick U. /Valencia U., IFIC /Wisconsin U., Madison /Rome U. /INFN, Rome /Edinburgh U. /Orsay, LAL

    2006-02-08

    This paper is based on the outcome of the activity that has taken place during the recent workshop on ''SuperB in Italy'' held in Frascati on November 11-12, 2005. The workshop was opened by a theoretical introduction of Marco Ciuchini and was structured in two working groups. One focused on the machine and the other on the detector and experimental issues.. The present status on CP is mainly based on the results achieved by BABAR and Belle. Establishment of the indirect CP violation in B sector in 2001 and of the direct CP violation in 2004 thanks to the success of PEP-II and KEKB e{sup +}e{sup -} asymmetric B Factories operating at the center of mass energy corresponding to the mass of the {Upsilon}(4S ). With the two B Factories taking data, the Unitarity Triangle is now beginning to be over constrained by improving the measurements of the sides and now also of the angles {alpha}, and {gamma}. We are also in presence of the very intriguing results about the measurements of sin2{beta} in the time dependent analysis of decay channels via penguin loops, where b {yields} s{bar s}s and b {yields} s{bar d}d. {tau} physics, in particular LFV search, as well as charm and ISR physics are important parts of the scientific program of a SuperB Factory. The physics case together with possible scenarios for the high luminosity SuperB Factory based on the concepts of the Linear Collider and the related experimental issues are discussed.

  16. UVUDF: UV Luminosity Functions at the Cosmic High Noon

    NASA Astrophysics Data System (ADS)

    Mehta, Vihang; Scarlata, Claudia; Rafelski, Marc; Gburek, Timothy; Teplitz, Harry I.; Alavi, Anahita; Boylan-Kolchin, Michael; Finkelstein, Steven; Gardner, Jonathan P.; Grogin, Norman; Koekemoer, Anton; Kurczynski, Peter; Siana, Brian; Codoreanu, Alex; de Mello, Duilia F.; Lee, Kyoung-Soo; Soto, Emmaris

    2017-03-01

    We present the rest-1500 Å UV luminosity functions (LF) for star-forming galaxies during the cosmic high noon—the peak of cosmic star formation rate at 1.5< z< 3. We use deep NUV imaging data obtained as part of the Hubble Ultra-Violet Ultra Deep Field (UVUDF) program, along with existing deep optical and NIR coverage on the HUDF. We select F225W, F275W, and F336W dropout samples using the Lyman break technique, along with samples in the corresponding redshift ranges selected using photometric redshifts, and measure the rest-frame UV LF at z∼ 1.7,2.2,3.0, respectively, using the modified maximum likelihood estimator. We perform simulations to quantify the survey and sample incompleteness for the UVUDF samples to correct the effective volume calculations for the LF. We select galaxies down to {M}{UV}=-15.9,-16.3,-16.8 and fit a faint-end slope of α =-{1.20}-0.13+0.10,-{1.32}-0.14+0.10,-{1.39}-0.12+0.08 at 1.4< z< 1.9, 1.8< z< 2.6, and 2.4< z< 3.6, respectively. We compare the star formation properties of z∼ 2 galaxies from these UV observations with results from Hα and UV+IR observations. We find a lack of high-SFR sources in the UV LF compared to the Hα and UV+IR, likely due to dusty SFGs not being properly accounted for by the generic {IRX}{--}β relation used to correct for dust. We compute a volume-averaged UV-to-Hα ratio by abundance matching the rest-frame UV LF and Hα LF. We find an increasing UV-to-Hα ratio toward low-mass galaxies ({M}\\star ≲ 5× {10}9 {M}ȯ ). We conclude that this could be due to a larger contribution from starbursting galaxies compared to the high-mass end.

  17. High-energy high-luminosity µ+ µ- collider design

    SciTech Connect

    Palmer, Robert B.; Fernow, Richard; Gallardo, Juan C.; Lee, Y. Y.; Torun, Yagmur; Neuffer, David; Winn, David

    1996-01-01

    We discuss the design of a high luminosity (1035 cm-2 s-1), high energy (2 + 2 TeV) µ+µ- collider, starting from the proton accelerator needed to generate the muon beams and proceeding through the muon storage ring.

  18. High Luminosity Heavy Quark and Electromagnetic Probes at RHIC

    SciTech Connect

    David, G; Frawley, A D; Rapp, R; Ullrich, T; Vogt, R; Xu, Z

    2008-03-30

    The Relativistic Heavy-Ion Collider (RHIC) at Brookhaven National Laboratory was designed to study the properties of quantum chromodynamics (QCD) in a hot and dense medium. The first years of RHIC operation and accompanying theoretical studies have helped pinpoint certain classes of measurements needed to more fully probe the medium and determine its properties. The medium created in these heavy-ion (AA) collisions appears to thermalize quickly and exhibits collective flow patterns consistent with hydrodynamic predictions. The initial temperature of the medium is not known and it is not yet understood whether deconfinement and chiral symmetry restoration are realized during its evolution. The answers to these questions require higher luminosities and detector upgrades, referred to as RHIC-II. The goal of RHIC II is to achieve the answers to the above questions by increasing the ion luminosity. The measurements thus far at RHIC could not fully address these fundamental questions, either due to incomplete detection capabilities or insufficient statistics to draw meaningful and robust conclusions. Working groups were formed to determine which physics topics could best be addressed by the combination of planned upgrades and increased luminosity. Reports from each working group were used to prepare a white paper for RHIC II, along with additional inputs from the conveners of all working groups.

  19. Detector Developments for the High Luminosity LHC Era (1/4)

    ScienceCinema

    None

    2016-07-12

    Calorimetry and Muon Spectrometers - Part I : In the first part of the lecture series, the motivation for a high luminosity upgrade of the LHC will be quickly reviewed together with the challenges for the LHC detectors. In particular, the plans and ongoing research for new calorimeter detectors will be explained. The main issues in the high-luminosity era are an improved radiation tolerance, natural ageing of detector components and challenging trigger and physics requirements. The new technological solutions for calorimetry at a high-luminosity LHC will be reviewed.

  20. High-frequency threshold measurements using insert earphones.

    PubMed

    Tang, H; Letowski, T

    1992-10-01

    Several recent studies have reported large intersubject variability of high-frequency thresholds measured with circumaural earphones. In the present study, high-frequency thresholds of 10 subjects were measured with circumaural (Sennheiser HD-250) and insert (Etymotic ER-1) earphones at 10, 12, 14, and 16 kHz. Overall results show significantly smaller variability of the threshold data obtained with insert earphones than with circumaural earphones. The above data indicate that insert earphones may be more suitable for high-frequency testing than circumaural earphones.

  1. UPGRADE OF RHIC VACUUM SYSTEMS FOR HIGH LUMINOSITY OPERATION.

    SciTech Connect

    HSEUH, H.C.; MAPES, M.; SMART, L.A.; TODD, R.; WEISS, D.

    2005-05-16

    With increasing ion beam intensity during recent RHIC operations, rapid pressure rises of several decades were observed at most warm sections and at a few cold sections. The pressure rises are associated with electron multi-pacting, electron stimulated desorption and beam ion induced desorption and have been one of the major intensity and luminosity limiting factors for RHIC. Improvement of the warm sections has been carried out in the last few years. Extensive in-situ bakes, additional UHV pumping and anti-grazing ridges have been implemented. Several hundred meters of NEG coated beam pipes have been installed and activated. Vacuum monitoring and logging were enhanced. Preventive measures, such as pumping before cool down to reduce monolayer condensates, were also taken to suppress the pressure rises in the cold sections. The effectiveness of these measures in reducing the pressure rises during machine studies and during physics runs are discussed and summarized.

  2. Spontaneous Radiation Emission from Short, High Field Strength Insertion Devices

    SciTech Connect

    Geoffrey Krafft

    2005-09-15

    Since the earliest papers on undulaters were published, it has been known how to calculate the spontaneous emission spectrum from ''short'' undulaters when the magnetic field strength parameter is small compared to unity, or in ''single'' frequency sinusoidal undulaters where the magnetic field strength parameter is comparable to or larger than unity, but where the magnetic field amplitude is constant throughout the undulater. Fewer general results have been obtained in the case where the insertion device is both short, i.e., the magnetic field strength parameter changes appreciably throughout the insertion device, and the magnetic field strength is high enough that ponderomotive effects, radiation retardation, and harmonic generation are important physical phenomena. In this paper a general method is presented for calculating the radiation spectrum for short, high-field insertion devices. It is used to calculate the emission from some insertion device designs of recent interest.

  3. Overview of a high luminosity {mu}{sup +}{mu}{sup {minus}} collider

    SciTech Connect

    Palmer, R.B.; Gallardo, J.C.

    1997-03-01

    Muon Colliders have unique technical and physics advantages and disadvantages when compared with both hadron and electron machines. They should be regarded as complementary. Parameters are given of a 4 TeV high luminosity {mu}{sup +}{mu}{sup {minus}} collider, and of a 0.5 TeV lower luminosity demonstration machine. The authors discuss the various systems in such muon colliders.

  4. Optical Variability of Two High-Luminosity Radio-Quiet Quasars, PDS 456 and PHL 1811

    NASA Astrophysics Data System (ADS)

    Gaskell, C. M.; Benker, A. J.; Campbell, J. S.; Crowley, K. A.; George, T. A.; Hedrick, C. H.; Hiller, M. E.; Klimek, E. S.; Leonard, J. P.; Peterson, B. W.; Sanders, K. M.

    2003-12-01

    PDS 456 and PHL 1811 are two of the highest luminosity low-redshift quasars. Both have optical luminosities comparable to 3C 273, but they have low radio luminosities. PDS 456 is a broad line object but PHL 1811 could be classified as a high-luminosity Narrow-Line Seyfert 1 (NLS1) object. We present the results of optical (V-band) continuum monitoring of PDS 456 and PHL 1811. We compare the variability properties of these two very different AGNs compared with the radio-loud AGN 3C 273, and we discuss the implications for the origin of the optical continuum variability in AGNs. This research has been supported in part by the Howard Hughes Foundation, Nebraska EPSCoR, the University of Nebraska Layman Fund, the University of Nebraska Undergraduate Creative Activities and Research Experiences, Pepsi-Cola, and the National Science Foundation through grant AST 03-07912.

  5. Evaluation of a high resolution silicon PET insert module

    NASA Astrophysics Data System (ADS)

    Grkovski, Milan; Brzezinski, Karol; Cindro, Vladimir; Clinthorne, Neal H.; Kagan, Harris; Lacasta, Carlos; Mikuž, Marko; Solaz, Carles; Studen, Andrej; Weilhammer, Peter; Žontar, Dejan

    2015-07-01

    Conventional PET systems can be augmented with additional detectors placed in close proximity of the region of interest. We developed a high resolution PET insert module to evaluate the added benefit of such a combination. The insert module consists of two back-to-back 1 mm thick silicon sensors, each segmented into 1040 1 mm2 pads arranged in a 40 by 26 array. A set of 16 VATAGP7.1 ASICs and a custom assembled data acquisition board were used to read out the signal from the insert module. Data were acquired in slice (2D) geometry with a Jaszczak phantom (rod diameters of 1.2-4.8 mm) filled with 18F-FDG and the images were reconstructed with ML-EM method. Both data with full and limited angular coverage from the insert module were considered and three types of coincidence events were combined. The ratio of high-resolution data that substantially improves quality of the reconstructed image for the region near the surface of the insert module was estimated to be about 4%. Results from our previous studies suggest that such ratio could be achieved at a moderate technological expense by using an equivalent of two insert modules (an effective sensor thickness of 4 mm).

  6. Wedge Absorbers for Final Cooling for a High-Energy High-Luminosity Lepton Collider

    SciTech Connect

    Neuffer, David; Mohayai, Tanaz; Snopok, Pavel; Summers, Don

    2016-06-01

    A high-energy high-luminosity muon collider scenario requires a "final cooling" system that reduces transverse emittance to ~25 microns (normalized) while allowing longitudinal emittance increase. Ionization cooling using high-field solenoids (or Li Lens) can reduce transverse emittances to ~100 microns in readily achievable configurations, confirmed by simulation. Passing these muon beams at ~100 MeV/c through cm-sized diamond wedges can reduce transverse emittances to ~25 microns, while increasing longitudinal emittance by a factor of ~5. Implementation will require optical matching of the exiting beam into downstream acceleration systems.

  7. ATLAS Upgrades Towards the High Luminosity LHC: extending the discovery potential

    NASA Astrophysics Data System (ADS)

    Valero-Biot, A.

    2014-06-01

    After successful LHC operation at the center-of-mass energy of 7 and 8 TeV in 2011 and 2012, plans are actively advancing for a series of upgrades, culminating roughly 10 years from now in the high luminosity LHC (HL-LHC) project, delivering of order five times the LHC nominal instantaneous luminosity along with luminosity leveling. The final goal is to extend the data set from about few hundred fb-1 expected for LHC running to 3000 fb-1 by around 2030. The current planning in ATLAS also foresees significant upgrades to the detector during the consolidation of the LHC to reach full LHC energy and further upgrades to accommodate running already beyond nominal luminosity this decade. The challenge of coping with HL-LHC instantaneous and integrated luminosity, along with the associated radiation levels, requires further major changes to the ATLAS detector. The designs are developing rapidly for an all-new inner-tracker, significant upgrades in the calorimeter and muon systems, as well as improved triggers and data acquisition. This presentation summarizes the various improvements to the ATLAS detector required to cope with the anticipated evolution of the LHC instantaneous luminosity during this decade and the next.

  8. Extra-galactic high-energy transients: event rate density and luminosity function

    NASA Astrophysics Data System (ADS)

    Sun, Hui; Zhang, Bing; Li, Zhuo

    2015-08-01

    Several types of extra-galactic high-energy transients have been discovered, which include high-luminosity and low-luminosity long-duration gamma-ray bursts (GRBs), short-duration GRBs, supernova shock breakouts (SBOs), and tidal disruption events (TDEs) without or with a relativistic jet. In this paper, we apply a unified method to systematically study the reshift-dependent event rate densities and luminosity functions of these extra-galactic high-energy transients. We consider star formation history as the tracer of the redshift distribution for long GRBs and SBOs. For short GRBs, we consider the compact star merger model to introduce several possible merger delay time distribution models. For TDEs, we consider the mass distribution of supermassive black holes as a function of redshift. We derive some empirical formulae for the redshift-dependent event rate density for different types of transients. Based on the observed events, we derive the local specific event rate density, ρ0,L ∝ dρ0/dL for each type of transient, which represents its luminosity function. All the transients are consistent with having a single power law luminosity function, except the high luminosity long GRBs (HL-lGRBs), whose luminosity function can be well described by a broken power law. The total event rate density for a particular transient depends on the luminosity threshold, and we obtain the following values in units of Gpc-3 yr-1: 2.82^{+0.41}_{-0.36} for HL-lGRBs above 4×1049 erg s-1 218^{+130}_{-86} for low luminosity long GRBs above 6×1046 erg s-1 3.18^{+0.88}_{-0.70}, 2.87^{+0.80}_{-0.64}, and 6.25^{+1.73}_{-1.38} above 5×1049 erg s-1 for short GRBs with three different merger delay models (Gaussian, log-normal, and power law); 2.0^{+2.6}_{-1.3}×104 above 9×1043 erg s-1 for SBOs, 3.0^{+1.0}_{-0.8}×105 for normal TDEs above 1042 erg s-1 and 6.2^{+8.2}_{-4.0} above 3×1047 erg s-1for TDE jets as discovered by Swift. Intriguingly, the global specific event rate densities

  9. An Alternative High Luminosity LHC with Flat Optics and Long-Range Beam-Beam Compensation

    SciTech Connect

    Fartoukh, Stephane; Valishev, Alexander; Shatilov, Dmitry

    2015-06-01

    In the baseline scenario of the High-Luminosity LHC (HL-LHC), the geometric loss of luminosity in the two high luminosity experiments due to collisions with a large crossing angle is recovered by tilting the bunches in the interaction region with the use of crab cavities. A possible backup scenario would rely on a reduced crossing angle together with flat optics (with different horizontal and vertical $\\beta^{\\ast}$values) for the preservation of luminosity performance. However, the reduction of crossing angle coupled with the flat optics significantly enhances the strength of long-range beam-beam interactions. This paper discusses the possibility to mitigate the long-range beam-beam effects by current bearing wire compensators (or e-lens). We develop a new HL-LHC parameter list and analyze it in terms of integrated luminosity performance as compared to the baseline. Further, we evaluate the operational scenarios using numerical simulations of single-particle dynamics with beam-beam effects.

  10. Morphology of high-luminosity compact radio sources.

    PubMed Central

    Zensus, J A; Krichbaum, T P; Lobanov, A P

    1995-01-01

    High-dynamic range imaging and monitoring with very-long-baseline interferometry reveal a rich morphology of luminous flat-spectrum radio sources. One-sided core-jet structures abound, and superluminal motion is frequently measured. In a few cases, both distinct moving features and diffuse underlying jet emission can be detected. Superluminal motion seen in such sources is typically complex, on curved trajectories or ridge lines, and with variable component velocities, including stationary features. The curved trajectories seen can be modeled by helical motion within the underlying jet flow. The very-long-baseline interferometry properties of the superluminal features in the jet of 3C 345 and other similar sources can be explained by models invoking the emission from shocks, at least within the vicinity of the compact core. Inverse-Compton calculations, constrained by x-ray observations, yield realistic estimates for the physical conditions in the parsec-scale jet. There is evidence for a transition region in this source beyond which other factors (e.g., plasma interactions and nonsynchrotron radiation processes) may become prominent. Multifrequency and polarization imaging (especially at high frequencies) are emerging as critical tools in testing model predictions. PMID:11607595

  11. Morphology of high-luminosity compact radio sources.

    PubMed

    Zensus, J A; Krichbaum, T P; Lobanov, A P

    1995-12-05

    High-dynamic range imaging and monitoring with very-long-baseline interferometry reveal a rich morphology of luminous flat-spectrum radio sources. One-sided core-jet structures abound, and superluminal motion is frequently measured. In a few cases, both distinct moving features and diffuse underlying jet emission can be detected. Superluminal motion seen in such sources is typically complex, on curved trajectories or ridge lines, and with variable component velocities, including stationary features. The curved trajectories seen can be modeled by helical motion within the underlying jet flow. The very-long-baseline interferometry properties of the superluminal features in the jet of 3C 345 and other similar sources can be explained by models invoking the emission from shocks, at least within the vicinity of the compact core. Inverse-Compton calculations, constrained by x-ray observations, yield realistic estimates for the physical conditions in the parsec-scale jet. There is evidence for a transition region in this source beyond which other factors (e.g., plasma interactions and nonsynchrotron radiation processes) may become prominent. Multifrequency and polarization imaging (especially at high frequencies) are emerging as critical tools in testing model predictions.

  12. High luminosity {mu}{sup +} {mu}{sup {minus}} collider: Report of a feasibility study

    SciTech Connect

    Palmer, R.B.; Gallardo, J.C.; Tollestrup, A.; Sessler, A.

    1996-12-01

    Parameters are given of 4 TeV and 0.5 TeV (c-of-m) high luminosity {mu}{sup +}{mu}{sup -} colliders, and of a 0.5 TeV lower luminosity demonstration machine. We discuss the various systems in such muon colliders, starting from the proton accelerator needed to generate the muons and proceeding through muon cooling, acceleration and storage in a collider ring. Detector background, polarization, and nonstandard operating conditions are analyzed. Muon Colliders have unique technical and physics advantages and disadvantages when compared with both hadron and electron machines. They should thus be regarded as complementary. We briefly mention the luminosity requirements of hadrons and lepton machines and their high-energy-physics advantages and disadvantages in reference to their effective center of mass energy. Finally, we present an R & D plan to determine whether such machines are practical.

  13. Nb3Sn High Field Magnets for the High Luminosity LHC Upgrade Project

    SciTech Connect

    Ambrosio, Giorgio

    2015-06-01

    The High Luminosity upgrade of the Large Hadron Collider at CERN requires a new generation of high field superconducting magnets. High field large aperture quadrupoles (MQXF) are needed for the low-beta triplets close to the ATLAS and CMS detectors, and high field two-in-one dipoles (11 T dipoles) are needed to make room for additional collimation. The MQXF quadrupoles, with a field gradient of 140 T/m in 150 mm aperture, have a peak coil field of 12.1 T at nominal current. The 11 T dipoles, with an aperture of 60 mm, have a peak coil field of 11.6 T at nominal current. Both magnets require Nb3Sn conductor and are the first applications of this superconductor to actual accelerator magnets.

  14. Extragalactic High-energy Transients: Event Rate Densities and Luminosity Functions

    NASA Astrophysics Data System (ADS)

    Sun, Hui; Zhang, Bing; Li, Zhuo

    2015-10-01

    Several types of extragalactic high-energy transients have been discovered, which include high-luminosity and low-luminosity long-duration gamma-ray bursts (GRBs), short-duration GRBs, supernova shock breakouts (SBOs), and tidal disruption events (TDEs) without or with an associated relativistic jet. In this paper, we apply a unified method to systematically study the redshift-dependent event rate densities and the global luminosity functions (GLFs; ignoring redshift evolution) of these transients. We introduce some empirical formulae for the redshift-dependent event rate densities for different types of transients and derive the local specific event rate density, which also represents its GLF. Long GRBs (LGRBs) have a large enough sample to reveal features in the GLF, which is best charaterized as a triple power law (PL). All the other transients are consistent with having a single-power-law (SPL) LF. The total event rate density depends on the minimum luminosity, and we obtain the following values in units of Gpc-3 yr-1: {0.8}-0.1+0.1 for high-luminosity LGRBs above 1050 erg s-1 {164}-65+98 for low-luminosity LGRBs above 5 × 1046 erg s-1 {1.3}-0.3+0.4, {1.2}-0.3+0.4, and {3.3}-0.8+1.0 above 1050 erg s-1 for short GRBs with three different merger delay models (Gaussian, lognormal, and PL); {1.9}-1.2+2.4× {10}4 above 1044 erg s-1 for SBOs, {4.8}-2.1+3.2× {10}2 for normal TDEs above 1044 erg s-1 and {0.03}-0.02+0.04 above 1048 erg s-1 for TDE jets as discovered by Swift. Intriguingly, the GLFs of different kinds of transients, which cover over 12 orders of magnitude, are consistent with an SPL with an index of -1.6.

  15. High-luminosity single carbon stars in stellar and galactic evolution

    NASA Technical Reports Server (NTRS)

    Jura, M.

    1991-01-01

    In the solar neighborhood, approximately half of all intermediate mass main sequence stars with initially between 1 solar mass and about 5 solar masses become carbon stars with luminosities near 10,000 lunar luminosities for typically less than 1 million years. These high luminosity carbon stars lose mass at rates nearly always in excess of 10 to the -7th solar mass/yr and sometimes in excess of 0.00001 solar mass/yr. Locally, close to half of the mass returned into the interstellar medium by intermediate mass stars before they become white dwarfs is during the carbon star phase. A much greater fraction of lower metallicity stars become carbon-rich before they evolve into planetary nebulae, than do higher-metallicity stars; therefore, carbon stars are much more important in the outer than in the inner Galaxy.

  16. Final Cooling For a High-luminosity High-Energy Lepton Collider

    SciTech Connect

    Neuffer, D.; Sayed, H.; Hart, T.; Summers, D.

    2015-05-01

    The final cooling system for a high-energy high-luminosity heavy lepton collider requires reduction of the transverse emittance εt by an order of magnitude to ~0.00003 m (rms, N), while allowing longitudinal emittance εL to increase to ~0.1m. In the present baseline approach, this is obtained by transverse cooling of low-energy muons within a sequence of high-field solenoids with low-frequency rf systems. Recent studies of such systems are presented. Since the final cooling steps are mostly emittance exchange, a variant form of that final system can be obtained by a round to flat transform in x-y, with transverse slicing of the enlarged flat transverse dimension followed by longitudinal recombination of the sliced bunchlets. Other variants are discussed. More explicit emittance exchange can greatly reduce the cost of a final cooling system.

  17. Accurate crab cavity modeling for the high luminosity Large Hadron Collider

    NASA Astrophysics Data System (ADS)

    Brett, D. R.; Appleby, R. B.; De Maria, R.; Garcia, J. Barranco; Garcia, R. Tomás; Hall, B.; Burt, G.

    2014-10-01

    As part of the Large Hadron Collider high luminosity upgrade it is proposed to include crab cavities in the lattice in order to enhance the luminosity. For one proposed cavity design the dynamics of the cavity is considered in terms of its impact upon the dynamic aperture of the machine. Taylor maps of the cavity are created and used to perform this analysis with a full assessment of their validity. Furthermore from these Taylor maps, symplectic methods are developed further, guided by the knowledge gained in the study of the physics contained in them.

  18. Detector Developments for the High Luminosity LHC Era (3/4)

    ScienceCinema

    None

    2016-07-12

    Tracking Detectors - Part I. Calorimetry, muon detection, vertexing, and tracking will play a central role in determining the physics reach for the High Luminosity LHC Era. In these lectures we will cover the requirements, options, and the R&D; efforts necessary to upgrade the current LHC detectors and enabling discoveries.

  19. Detector Developments for the High Luminosity LHC Era (4/4)

    ScienceCinema

    None

    2016-07-12

    Tracking Detectors - Part II. Calorimetry, muon detection, vertexing, and tracking will play a central role in determining the physics reach for the High Luminosity LHC Era. In these lectures we will cover the requirements, options, and the R&D; efforts necessary to upgrade the current LHC detectors and enabling discoveries.

  20. Pulsational instability of high-luminosity H-rich pre-white dwarf star

    NASA Astrophysics Data System (ADS)

    Calcaferro, Leila M.; Córsico, Alejandro H.; Camisassa, María E.; Althaus, Leandro G.; Shibahashi, Hiromoto

    2017-09-01

    We present a pulsational stability analysis on high-luminosity H-rich (DA) white dwarf models evolved from low-metallicity progenitors. We found that the ɛ mechanism due to H-shell burning is able to excite low-order g modes.

  1. Detector Developments for the High Luminosity LHC Era (4/4)

    SciTech Connect

    2010-09-22

    Tracking Detectors - Part II. Calorimetry, muon detection, vertexing, and tracking will play a central role in determining the physics reach for the High Luminosity LHC Era. In these lectures we will cover the requirements, options, and the R&D; efforts necessary to upgrade the current LHC detectors and enabling discoveries.

  2. Detector Developments for the High Luminosity LHC Era (3/4)

    SciTech Connect

    2010-09-22

    Tracking Detectors - Part I. Calorimetry, muon detection, vertexing, and tracking will play a central role in determining the physics reach for the High Luminosity LHC Era. In these lectures we will cover the requirements, options, and the R&D; efforts necessary to upgrade the current LHC detectors and enabling discoveries.

  3. Theoretical studies of hadronic calorimetry for high luminosity, high energy colliders

    SciTech Connect

    Brau, J.E.; Gabriel, T.A.

    1989-01-01

    Experiments at the high luminosity, high energy colliders of the future are going to demand optimization of the state of the art of calorimetry design and construction. During the past few years, the understanding of the basic phenomenology of hadron calorimeters has advanced through paralleled theoretical and experimental investigations. The important underlying processes are reviewed to set the framework for the presentation of recent calculations of the expected performance of silicon detector based hadron calorimeters. Such devices employing uranium are expected to achieve the compensation condition (that is, e/h approx. 1.0) based on the understanding that has been derived from the uranium-liquid argon and uranium-plastic scintillator systems. In fact, even lead-silicon calorimeters are found to achieve the attractive value for the e/h ratio of 1.16 at 10 GeV. 62 refs., 22 figs., 3 tabs.

  4. Populations of High-Luminosity Density-Bounded HII Regions in Spiral Galaxies? Evidence and Implications

    NASA Technical Reports Server (NTRS)

    Beckman, J. E.; Rozas, M.; Zurita, A.; Watson, R. A.; Knapen, J. H.

    2000-01-01

    In this paper we present evidence that the H II regions of high luminosity in disk galaxies may be density bounded, so that a significant fraction of the ionizing photons emitted by their exciting OB stars escape from the regions. The key piece of evidence is the presence, in the Ha luminosity functions (LFs) of the populations of H iI regions, of glitches, local sharp peaks at an apparently invariant luminosity, defined as the Stromgren luminosity Lstr), LH(sub alpha) = Lstr = 10(sup 38.6) (+/- 10(sup 0.1)) erg/ s (no other peaks are found in any of the LFs) accompanying a steepening of slope for LH(sub alpha) greater than Lstr This behavior is readily explicable via a physical model whose basic premises are: (a) the transition at LH(sub alpha) = Lstr marks a change from essentially ionization bounding at low luminosities to density bounding at higher values, (b) for this to occur the law relating stellar mass in massive star-forming clouds to the mass of the placental cloud must be such that the ionizing photon flux produced within the cloud is a function which rises more steeply than the mass of the cloud. Supporting evidence for the hypothesis of this transition is also presented: measurements of the central surface brightnesses of H II regions for LH(sub alpha) less than Lstr are proportional to L(sup 1/3, sub H(sub alpha)), expected for ionization bounding, but show a sharp trend to a steeper dependence for LH(sub alpha) greater than Lstr, and the observed relation between the internal turbulence velocity parameter, sigma, and the luminosity, L, at high luminosities, can be well explained if these regions are density bounded. If confirmed, the density-bounding hypothesis would have a number of interesting implications. It would imply that the density-bounded regions were the main sources of the photons which ionize the diffuse gas in disk galaxies. Our estimates, based on the hypothesis, indicate that these regions emit sufficient Lyman continuum not only to

  5. Long term dynamics of the high luminosity Large Hadron Collider with crab cavities

    NASA Astrophysics Data System (ADS)

    Barranco García, J.; De Maria, R.; Grudiev, A.; Tomás García, R.; Appleby, R. B.; Brett, D. R.

    2016-10-01

    The High Luminosity upgrade of the Large Hadron Collider (HL-LHC) aims to achieve an integrated luminosity of 200 - 300 fb-1 per year, including the contribution from the upgrade of the injector chain. For the HL-LHC the larger crossing angle together with a smaller beta function at the collision point would result in more than 70% luminosity loss due to the incomplete geometric overlap of colliding bunches. To recover head-on collisions at the high-luminosity particle-physics detectors ATLAS and CMS and benefit from the very low β* provided by the Achromatic Telescopic Squeezing (ATS) optics, a local crab cavity scheme provides transverse kicks to the proton bunches. The tight space constraints at the location of these cavities leads to designs which are axially non-symmetric, giving rise to high order multipoles components of the main deflecting mode and, since these kicks are harmonic in time, we expand them in a series of multipoles in a similar fashion as is done for static field magnets. In this work we calculate, for the first time, the higher order multipoles and their impact on beam dynamics for three different crab cavity prototypes. Different approaches to calculate the multipoles are presented. Furthermore, we perform the first calculation of their impact on the long term stability of the machine using the concept of dynamic aperture.

  6. Luminosity enhancements at SLAC

    SciTech Connect

    Coward, D.H.

    1984-04-01

    Several ideas are discussed that have been proposed to improve the luminosity at the SPEAR and PEP electron-positron storage rings and to insure good luminosity at the SLAC Linear Collider. There have been two proposals studied recently for SPEAR: a Microbeta insertion using Samarium Cobalt permanent magnets, and a Minibeta insertion using conventional quadrupole magnets. The notations Microbeta and minibeta used here are somewhat arbitrary since the front faces of the first quadrupole magnets for both insertions are at nearly the same distance from the interaction point.

  7. The radiation hardness and temperature stability of Planar Light-wave Circuit splitters for the High Luminosity LHC

    NASA Astrophysics Data System (ADS)

    Ryder, N. C.; Hamilton, P.; Huffman, B. T.; Teng, P. K.; Weidberg, A. R.; Issever, C.

    2011-10-01

    High Luminosity LHC (HL-LHC) Inner Tracker designs may include the sharing of Timing, Trigger and Control (TTC) signals between several tracker modules. This is possible because the highest frequency signals are common to all modules. Such designs are an attractive option because they reduce the number of optical links required and hence the cost. These designs will require optical signal splitters that are radiation hard up to high doses and capable of operating in cold temperatures. Optical splitters are available as either fused-fibre splitters or Planar Light-wave Circuit (PLC) splitters. PLC splitters are preferable because they are smaller than fused-fibre splitters. A selection of PLC splitters from different manufacturers and of two different technologies (silica and glass based) have been tested for radiation hardness up to a dose of 500 kGy(Si) and for temperature stability. All the tested splitters displayed small increases in insertion losses ( < 0.1 dB) in reducing the operating temperature from 25°C to -25°C. The silica based splitters from all manufacturers did not exhibit significant radiation induced insertion losses, despite the high dose they were exposed to. The glass based sample, however, had a per channel radiation induced insertion loss of up to 1.16 dB. Whilst the silica based splitters can be considered as qualified for HL-LHC use with regards to radiation hardness, the glass technology would require further testing at a lower, more realistic, dose to also be considered as a potential component for HL-LHC upgrade designs.

  8. Long Term Optical and Infrared Reverberation Mapping of High and Low Luminosity Active Galactic Nuclei

    NASA Astrophysics Data System (ADS)

    Gorjian, Varoujan; Barth, Aaron; Brandt, Niel; Dawson, Kyle; Green, Paul; Ho, Luis; Horne, Keith; Jiang, Linhua; Joner, Mike; Kenney, John; McGreer, Ian; Nordgren, Tyler; Schneider, Donald; Shen, Yue; Tao, Charling

    2016-08-01

    Previous Spitzer reverberation monitoring projects looking for UV/optical light absorbed and re-emitted in the IR by dust have been limited to very low luminosity active galactic nuclei (AGN) that could potentially show reverberation within a single cycle (~1 year). Cycle 11-12's two year baseline allowed for the reverberation mapping of 17 high luminosity quasars from the Sloan Digital Sky Survey Reverberation Mapping project. By combining ground based monitoring from Pan-STARRS, CFHT, and Steward Observatory telescopes with Spitzer data we have for the first time detected dust reverberation in quasars. We propose to continue this project to capitalize on the continuing optical motnoring from the ground and to increase the confidence in the detected lags. Additionally, the Call for Proposals asks for up to 1000 hours of observations in the Spitzer CVZ to accommodate battery charging needs. We propose to add to our quasar sample five lower luminosity Seyfert galaxies from the Pan-STARRS ground based optical survey that are in the Spitzer CVZ, which will increase the luminosity range of AGN we are studying and, combined with additional ground based observatories, provide for a continuous monitoring campaign lasting 2 years and thus provide the most detailed study of dust around AGN to date.

  9. Attaining high luminosity in linear e sup + e sup minus colliders

    SciTech Connect

    Palmer, R.B.

    1990-11-01

    The attainment of high luminosity in linear colliders is a complex problem because of the interdependence of the critical parameters. For instance, changing the number of particles per bunch affects the damping ring design and thus the emittance; it affects the wakefields in the linac and thus the momentum spread; the momentum spread affects the final focus design and thus the final {beta}*; but the emittance change also affects the final focus design; and all these come together to determine the luminosity, disruption and beamstrahlung at the intersection. Changing the bunch length, or almost any other parameter, has a similar chain reaction. Dealing with this problem by simple scaling laws is very difficult because one does not know which parameter is going to be critical, and thus which should be held constant. One can only maximize the luminosity by a process of search and iteration. The process can be facilitated with the aid of a computer program. Examples can then be optimized for maximum luminosity, and compared to the optimized solutions with different approaches. This paper discusses these approaches.

  10. The ATLAS Fast Tracker and Tracking at the High-Luminosity LHC

    NASA Astrophysics Data System (ADS)

    Ilic, N.

    2017-02-01

    The increase in centre-of-mass energy and luminosity of the Large Hadron Collider makes controlling trigger rates with high efficiency challenging. The ATLAS Fast TracKer is a hardware processor built to reconstruct tracks at a rate of up to 100 kHz and provide them to the high level trigger. The tracker reconstructs tracks by matching incoming detector hits with pre-defined track patterns stored in associative memory on custom ASICs. Inner detector hits are fitted to these track patterns using modern FPGAs. This proceeding describe the electronics system used for the massive parallelization performed by the Fast TracKer. An overview of the installation, commissioning and running of the system is given. The ATLAS upgrades planned to enable tracking at the High-Luminosity Large Hadron Collider are also discussed.

  11. The New Transfer Line Collimation System for the LHC High Luminosity Era

    SciTech Connect

    Kain, Verena; Bracco, Chiara; Goddard, Brennan; Maciariello, Fausto; Meddahi, Malika; Mereghetti, Alessio; Steele, Genevieve; Velotti, Francesco; Gianfelice-Wendt, Eliana

    2014-07-01

    A set of passive absorbers is located at the end of each of the 3 km long injection lines to protect the LHC in case of failures during the extraction process from the LHC’s last pre-injector or the beam transfer itself. In case of an erroneous extraction, the absorbers have to attenuate the beam to a safe level and be robust enough themselves to survive the impact. These requirements are difficult to fulfil with the very bright and intense beams produced by the LHC injectors for the high luminosity era. This paper revisits the requirements for the SPS-to-LHC transfer line collimation system and the adapted strategy to fulfill these for the LHC high luminosity operation. A possible solution for the new transfer line collimation system is presented.

  12. High-energy high-luminosity electron-ion collider eRHIC

    SciTech Connect

    Litvinenko, V.N.; Ben-Zvi, I.; Hammons, L.; Hao, Y.; Webb, S.; et al

    2011-08-09

    In this paper, we describe a future electron-ion collider (EIC), based on the existing Relativistic Heavy Ion Collider (RHIC) hadron facility, with two intersecting superconducting rings, each 3.8 km in circumference. The replacement cost of the RHIC facility is about two billion US dollars, and the eRHIC will fully take advantage and utilize this investment. We plan adding a polarized 5-30 GeV electron beam to collide with variety of species in the existing RHIC accelerator complex, from polarized protons with a top energy of 325 GeV, to heavy fully-striped ions with energies up to 130 GeV/u. Brookhaven's innovative design, is based on one of the RHIC's hadron rings and a multi-pass energy-recovery linac (ERL). Using the ERL as the electron accelerator assures high luminosity in the 10{sup 33}-10{sup 34} cm{sup -2} sec{sup -1} range, and for the natural staging of eRHIC, with the ERL located inside the RHIC tunnel. The eRHIC will provide electron-hadron collisions in up to three interaction regions. We detail the eRHIC's performance in Section 2. Since first paper on eRHIC paper in 2000, its design underwent several iterations. Initially, the main eRHIC option (the so-called ring-ring, RR, design) was based on an electron ring, with the linac-ring (LR) option as a backup. In 2004, we published the detailed 'eRHIC 0th Order Design Report' including a cost-estimate for the RR design. After detailed studies, we found that an LR eRHIC has about a 10-fold higher luminosity than the RR. Since 2007, the LR, with its natural staging strategy and full transparency for polarized electrons, became the main choice for eRHIC. In 2009, we completed technical studies of the design and dynamics for MeRHIC with 3-pass 4 GeV ERL. We learned much from this evaluation, completed a bottom-up cost estimate for this $350M machine, but then shelved the design. In the same year, we turned again to considering the cost-effective, all-in-tunnel six-pass ERL for our design of the high-luminosity

  13. Beam Losses in the NLC Extraction Line for High Luminosity Beam Parameters (LCC-0049)

    SciTech Connect

    Nosochkov, Y

    2004-03-19

    In this note we present results of beam tracking in the NLC extraction line for the NLC option with high luminosity beam parameters (option H). Particle losses for 0.5 TeV and 1 TeV cms energy beams have been computed and examined as a function of beam offset at the interaction point (IP). Updated tracking results for the NLC option A are presented as well.

  14. From Nearby Low Luminosity AGN to High Redshift Radio Galaxies: Science Interests with Square Kilometre Array

    NASA Astrophysics Data System (ADS)

    Kharb, P.; Lal, D. V.; Singh, V.; Bagchi, J.; Ishwara Chandra, C. H.; Hota, A.; Konar, C.; Wadadekar, Y.; Shastri, P.; Das, M.; Baliyan, K.; Nath, B. B.; Pandey-Pommier, M.

    2016-12-01

    We present detailed science cases that a large fraction of the Indian AGN community is interested in pursuing with the upcoming Square Kilometre Array (SKA). These interests range from understanding low luminosity active galactic nuclei in the nearby Universe to powerful radio galaxies at high redshifts. Important unresolved science questions in AGN physics are discussed. Ongoing low-frequency surveys with the SKA pathfinder telescope GMRT, are highlighted.

  15. Line and continuum variability of two intermediate-redshift, high-luminosity quasars

    NASA Astrophysics Data System (ADS)

    Trevese, D.; Paris, D.; Stirpe, G. M.; Vagnetti, F.; Zitelli, V.

    2007-08-01

    Context: It has been shown that the luminosity of active galactic nuclei and the size of their broad line region obey a simple relation of the type R_BLR=a Lγ, from faint Seyfert nuclei to bright quasars, allowing single-epoch determination of the central black hole mass M_BH= b Lγ Δ^2_Hβ from their luminosity L and width of Hβ emission line. Adopting this mass determination for cosmological studies requires the extrapolation to high redshift and luminosity of a relation whose calibration relies so far on reverberation mapping measurements performed for L ⪉ 1046 erg s-1 and redshift z ⪉ 0.4. Aims: We initiated a campaign for the spectrophotometric monitoring of a few luminous, intermediate redshift quasars whose apparent magnitude, V < 15.7, allows observations with a 1.8 m telescope, aimed at proving that emission lines vary and respond to continuum variations even for luminosities ⪆1047 erg s-1, and determining eventually their M_BH from reverberation mapping. Methods: We have repeatedly performed simultaneous spectrophotometric observations of quasars and reference stars to determine relative variability of continuum and emission lines. We describe the observations and methods of analysis. Results: For the quasars PG 1634+706 and PG 1247+268 we obtain light-curves respectively for CIII] (λλ1909 Å), MgII(λλ2798 Å) and for CIV(λλ1549 Å), CIII] (λλ1909 Å) emission lines with the relevant continua. During 3.2 years of observation, in the former case no continuum variability was detected and the evidence for line variability is marginal, while in the latter case both continuum and line variability are detected with high significance and the line variations appear correlated with continuum variations. Conclusions: The detection of the emission line variability in a quasar with L ~ 1047 erg s-1 encourages the continuation of the monitoring campaign which should provide a black hole mass estimate in another 5-6 years, constraining the mass-luminosity

  16. High-Luminosity Large Hadron Collider (HL-LHC) : Preliminary Design Report

    SciTech Connect

    Apollinari, G.; Béjar Alonso, I.; Brüning, O.; Lamont, M.; Rossi, L.

    2015-12-17

    The Large Hadron Collider (LHC) is one of the largest scientific instruments ever built. Since opening up a new energy frontier for exploration in 2010, it has gathered a global user community of about 7,000 scientists working in fundamental particle physics and the physics of hadronic matter at extreme temperature and density. To sustain and extend its discovery potential, the LHC will need a major upgrade in the 2020s. This will increase its luminosity (rate of collisions) by a factor of five beyond the original design value and the integrated luminosity (total collisions created) by a factor ten. The LHC is already a highly complex and exquisitely optimised machine so this upgrade must be carefully conceived and will require about ten years to implement. The new configuration, known as High Luminosity LHC (HL-LHC), will rely on a number of key innovations that push accelerator technology beyond its present limits. Among these are cutting-edge 11-12 tesla superconducting magnets, compact superconducting cavities for beam rotation with ultra-precise phase control, new technology and physical processes for beam collimation and 300 metre-long high-power superconducting links with negligible energy dissipation. The present document describes the technologies and components that will be used to realise the project and is intended to serve as the basis for the detailed engineering design of HL-LHC.

  17. The Physics Program of a High-Luminosity Asymmetric B Factory at SLAC

    SciTech Connect

    Eisner, A.; Mandelkern, M.; Morrison, R.; Witherell, M.; Burchat, P.; Kent, J.; Erbacher, R.; Vernon, W.; Eigen, G.; Hitlin, D.; Porter, F.; Weinstein, A.; Wisniewski, W.; Wagner, S.; Franzini, P.; Tuts, M.; Averill, D.; Snyder, A.; Goldhaber, G.; Oddone, P.; Roe, N.; Ronan, M.; Spahn, M.; MacFarlane, D.; Bartelt, J.; Bloom, E.; Bulos, F.; Cords, D.; Dib, C.; Dorfan, J.; Dunietz, I.; Gilman, F.; Godfrey, G.; Hyer, T.; Jensen, G.; Leith, D.; Marsiske, H.; Nir, Y.; Lee-Franzini, J.

    1989-10-01

    A high-luminosity asymmetric energy B Factory, proposed as an upgrade to the PEP storage ring at SLAC, provides the best opportunity to study CP violation as a means of testing the consistency of the Standard Model. If the phenomenon of CP violation is xplained by the Standard Model simply through the non-zero angles and phase of the Kobayashi-Maskawa matrix, then there are precise relations between the K-M parameters and the various measurable CP-violating asymmetries in B meson decay. Should these onsistency relations fail, the origin of CP violation must lie outside the Standard Model framework. Our measurements would then lead to the first experiment-driven extensions of the Standard Model. The B Factory will also carry out a varied, high-quality program of studies f other aspects of the physics of b quarks, as well as high-precision measurements in r and charm physics. We describe a detailed series of measurements to be carried out in the first few years at a peak luminosity of 3 x 10{sup 33} cm{sup -2}sec{sup -1}, the initial luminosity goal of the B Factory, as well as the program accessible to a larger data sample.

  18. Astronaut Rich Clifford inserts tape into payload high data recorder

    NASA Image and Video Library

    1994-04-14

    STS059-09-012 (9-20 April 1994) --- On the Space Shuttle Endeavour's aft flight deck, astronaut Michael R. (Rich) Clifford, mission specialist, inserts a tape in the payload high rate recorder. Three of these state-of-the-art recorders captured four times the amount of data that could be radioed to the ground. The 183 tapes, each containing 40 megabytes of data, will be turned into images over the next year, and analyzed over the next decade. Clifford was joined in space by five other NASA astronauts for a week and a half of support to the Space Radar Laboratory (SRL-1)/STS-59 mission.

  19. The Upgrade of the L3 Third Level Trigger for High Luminosity Runs at LEP.

    NASA Astrophysics Data System (ADS)

    Bracci, S.; Cai, X. D.; De Salvo, A.; Falciano, S.; Klimentov, A.; Luci, C.; Ludovici, L.; Luminari, L.; Martin, B.; Marzano, F.; Medici, G.; Mirabelli, G.

    1995-11-01

    The third level trigger of the L3 experiment has been upgraded to cope with the high luminosity currently reached at LEP (˜ 1.4 · 10 31cm-2s-1). The new hardware implementation is based on a farm of four VAXstations 4000/90, which receive data through FASTBUS to SCSI interfaces and send accepted events to the main online computer via FDDI. A new software architecture, which makes extensive use of VMS interprocess communication tools, has been built. The current filter algorithms, briefly described here, ensure an output rate of less than 1.5 Hz (in addition to the events used to measure the luminosity) with a very low background contamination. The trigger efficiency, studied with the leptonic Z decays, is 100%.

  20. X-ray constraints on the fraction of obscured active galactic nuclei at high accretion luminosities

    NASA Astrophysics Data System (ADS)

    Georgakakis, A.; Salvato, M.; Liu, Z.; Buchner, J.; Brandt, W. N.; Ananna, T. Tasnim; Schulze, A.; Shen, Yue; LaMassa, S.; Nandra, K.; Merloni, A.; McGreer, I. D.

    2017-08-01

    The wide-area XMM-XXL X-ray survey is used to explore the fraction of obscured active galactic nuclei (AGNs) at high accretion luminosities, LX(2-10 keV) ≳ 1044 erg s - 1, and out to redshift z ≈ 1.5. The sample covers an area of about 14 deg2 and provides constraints on the space density of powerful AGNs over a wide range of neutral hydrogen column densities extending beyond the Compton-thick limit, NH ≈ 1024 cm - 2. The fraction of obscured Compton-thin (NH = 1022-1024 cm - 2) AGNs is estimated to be ≈0.35 for luminosities LX(2-10 keV) > 1044 erg s - 1, independent of redshift. For less luminous sources, the fraction of obscured Compton-thin AGNs increases from 0.45 ± 0.10 at z = 0.25 to 0.75 ± 0.05 at z = 1.25. Studies that select AGNs in the infrared via template fits to the observed spectral energy distribution of extragalactic sources estimate space densities at high accretion luminosities consistent with the XMM-XXL constraints. There is no evidence for a large population of AGNs (e.g. heavily obscured) identified in the infrared and missed at X-ray wavelengths. We further explore the mid-infrared colours of XMM-XXL AGNs as a function of accretion luminosity, column density and redshift. The fraction of XMM-XXL sources that lie within the mid-infrared colour wedges defined in the literature to select AGNs is primarily a function of redshift. This fraction increases from about 20-30 per cent at z = 0.25 to about 50-70 per cent at z = 1.5.

  1. Upgrade of the ATLAS hadronic Tile Calorimeter for the High luminosity LHC

    NASA Astrophysics Data System (ADS)

    Solodkov, A.

    2017-08-01

    The Tile Calorimeter (TileCal) is the hadronic calorimeter of ATLAS covering the central region of the ATLAS experiment. TileCal is a sampling calorimeter with steel as absorber and scintillators as active medium. The scintillators are read out by wavelength shifting fibers coupled to photomultiplier tubes (PMT). The analogue signals from the PMTs are amplified, shaped and digitized by sampling the signal every 25 ns. The High Luminosity Large Hadron Collider (HL-LHC) will have a peak luminosity of 5 × 1034 cm-2s-1, five times higher than the design luminosity of the LHC . TileCal will undergo a major replacement of its on- and off-detector electronics for the high luminosity programme of the LHC starting in 2026. All signals will be digitized and then transferred directly to the off-detector electronics, where the signals will be reconstructed, stored, and sent to the first level of trigger at a rate of 40 MHz. This will provide better precision of the calorimeter signals used by the trigger system and will allow the development of more complex trigger algorithms. Changes to the electronics will also contribute to the reliability and redundancy of the system. Three different front-end options are presently being investigated for the upgrade and a final solution will be chosen after extensive laboratory and test beam studies that are in progress. A hybrid demonstrator module was developed using the new electronics while conserving compatibility with the current system. The demonstrator undergoes extensive testing and will be installed in ATLAS during one of the next winter maintenance periods.

  2. An incremental high-utility mining algorithm with transaction insertion.

    PubMed

    Lin, Jerry Chun-Wei; Gan, Wensheng; Hong, Tzung-Pei; Zhang, Binbin

    2015-01-01

    Association-rule mining is commonly used to discover useful and meaningful patterns from a very large database. It only considers the occurrence frequencies of items to reveal the relationships among itemsets. Traditional association-rule mining is, however, not suitable in real-world applications since the purchased items from a customer may have various factors, such as profit or quantity. High-utility mining was designed to solve the limitations of association-rule mining by considering both the quantity and profit measures. Most algorithms of high-utility mining are designed to handle the static database. Fewer researches handle the dynamic high-utility mining with transaction insertion, thus requiring the computations of database rescan and combination explosion of pattern-growth mechanism. In this paper, an efficient incremental algorithm with transaction insertion is designed to reduce computations without candidate generation based on the utility-list structures. The enumeration tree and the relationships between 2-itemsets are also adopted in the proposed algorithm to speed up the computations. Several experiments are conducted to show the performance of the proposed algorithm in terms of runtime, memory consumption, and number of generated patterns.

  3. L1Track: A fast Level 1 track trigger for the ATLAS high luminosity upgrade

    NASA Astrophysics Data System (ADS)

    Cerri, Alessandro

    2016-07-01

    With the planned high-luminosity upgrade of the LHC (HL-LHC), the ATLAS detector will see its collision rate increase by approximately a factor of 5 with respect to the current LHC operation. The earliest hardware-based ATLAS trigger stage ("Level 1") will have to provide a higher rejection factor in a more difficult environment: a new improved Level 1 trigger architecture is under study, which includes the possibility of extracting with low latency and high accuracy tracking information in time for the decision taking process. In this context, the feasibility of potential approaches aimed at providing low-latency high-quality tracking at Level 1 is discussed.

  4. Energy deposition studies for the high-luminosity Large Hadron Collider inner triplet magnets

    DOE PAGES

    Mokhov, N. V.; Rakhno, I. L.; Tropin, I. S.; ...

    2015-05-06

    A detailed model of the high-luminosity LHC inner triplet region with new large-aperture Nb3Sn magnets, field maps, corrector packages, and segmented tungsten inner absorbers was built and implemented into the fluka and mars15 codes. Detailed simulations have been performed coherently with the codes on the impact of particle debris from the 14-TeV center-of-mass pp-collisions on the short- and long-term stability of the inner triplet magnets. After optimizing the absorber configuration, the peak power density averaged over the magnet inner cable width is found to be safely below the quench limit at the luminosity of 5×1034 cm-2s-1. For the anticipated lifetimemore » integrated luminosity of 3000 fb-1, the peak dose calculated for the innermost magnet insulator ranges from 20 to 35 MGy, a figure close to the commonly accepted limit. Dynamic heat loads to the triplet magnet cold mass are calculated to evaluate the cryogenic capability. fluka and mars results on energy deposition are in very good agreement.« less

  5. Energy deposition studies for the high-luminosity Large Hadron Collider inner triplet magnets

    NASA Astrophysics Data System (ADS)

    Mokhov, N. V.; Rakhno, I. L.; Tropin, I. S.; Cerutti, F.; Esposito, L. S.; Lechner, A.

    2015-05-01

    A detailed model of the high-luminosity LHC inner triplet region with new large-aperture Nb3Sn magnets, field maps, corrector packages, and segmented tungsten inner absorbers was built and implemented into the fluka and mars15 codes. Detailed simulations have been performed coherently with the codes on the impact of particle debris from the 14-TeV center-of-mass pp-collisions on the short- and long-term stability of the inner triplet magnets. After optimizing the absorber configuration, the peak power density averaged over the magnet inner cable width is found to be safely below the quench limit at the luminosity of 5 ×1034 cm-2 s-1 . For the anticipated lifetime integrated luminosity of 3000 fb-1 , the peak dose calculated for the innermost magnet insulator ranges from 20 to 35 MGy, a figure close to the commonly accepted limit. Dynamic heat loads to the triplet magnet cold mass are calculated to evaluate the cryogenic capability. fluka and mars results on energy deposition are in very good agreement.

  6. First Test Results of the 150 mm Aperture IR Quadrupole Models for the High Luminosity LHC

    SciTech Connect

    Ambrosio, G.; Chlachidze, G.; Wanderer, P.; Ferracin, P.; Sabbi, G.

    2016-10-06

    The High Luminosity upgrade of the LHC at CERN will use large aperture (150 mm) quadrupole magnets to focus the beams at the interaction points. The high field in the coils requires Nb3Sn superconductor technology, which has been brought to maturity by the LHC Accelerator Re-search Program (LARP) over the last 10 years. The key design targets for the new IR quadrupoles were established in 2012, and fabrication of model magnets started in 2014. This paper discusses the results from the first single short coil test and from the first short quadrupole model test. Remaining challenges and plans to address them are also presented and discussed.

  7. Detecting Alu insertions from high-throughput sequencing data

    PubMed Central

    David, Matei; Mustafa, Harun; Brudno, Michael

    2013-01-01

    High-throughput sequencing technologies have allowed for the cataloguing of variation in personal human genomes. In this manuscript, we present alu-detect, a tool that combines read-pair and split-read information to detect novel Alus and their precise breakpoints directly from either whole-genome or whole-exome sequencing data while also identifying insertions directly in the vicinity of existing Alus. To set the parameters of our method, we use simulation of a faux reference, which allows us to compute the precision and recall of various parameter settings using real sequencing data. Applying our method to 100 bp paired Illumina data from seven individuals, including two trios, we detected on average 1519 novel Alus per sample. Based on the faux-reference simulation, we estimate that our method has 97% precision and 85% recall. We identify 808 novel Alus not previously described in other studies. We also demonstrate the use of alu-detect to study the local sequence and global location preferences for novel Alu insertions. PMID:23921633

  8. High luminosity operation of large solid angle scintillator arrays in Jefferson Lab Hall A

    SciTech Connect

    Shneor, Ran

    2003-12-01

    This thesis describes selected aspects of high luminosity operation of large solid angle scintillator arrays in Hall A of the CEBAF (Central Electron Beam Accelerator Facility) at TJNAF (Thomas Jefferson National Accelerator Facility ). CEBAF is a high current, high duty factor electron accelerator with a maximum beam energy of about 6 GeV and a maximum current of 200 μA. Operating large solid angle scintillator arrays in high luminosity environment presents several problems such as high singles rates, low signal to noise ratios and shielding requirements. To demonstrate the need for large solid angle and momentum acceptance detectors as a third arm in Hall A, we will give a brief overview of the physics motivating five approved experiments, which utilize scintillator arrays. We will then focus on the design and assembly of these scintillator arrays, with special focus on the two new detector packages built for the Short Range Correlation experiment E01-015. This thesis also contains the description and results of different tests and calibrations which where conducted for these arrays. We also present the description of a number of tests which were done in order to estimate the singles rates, data reconstruction, filtering techniques and shielding required for these counters.

  9. Evaluation of GPUs as a level-1 track trigger for the High-Luminosity LHC

    NASA Astrophysics Data System (ADS)

    Mohr, H.; Dritschler, T.; Ardila, L. E.; Balzer, M.; Caselle, M.; Chilingaryan, S.; Kopmann, A.; Rota, L.; Schuh, T.; Vogelgesang, M.; Weber, M.

    2017-04-01

    In this work, we investigate the use of GPUs as a way of realizing a low-latency, high-throughput track trigger, using CMS as a showcase example. The CMS detector at the Large Hadron Collider (LHC) will undergo a major upgrade after the long shutdown from 2024 to 2026 when it will enter the high luminosity era. During this upgrade, the silicon tracker will have to be completely replaced. In the High Luminosity operation mode, luminosities of 5-7 × 1034 cm-2s-1 and pileups averaging at 140 events, with a maximum of up to 200 events, will be reached. These changes will require a major update of the triggering system. The demonstrated systems rely on dedicated hardware such as associative memory ASICs and FPGAs. We investigate the use of GPUs as an alternative way of realizing the requirements of the L1 track trigger. To this end we implemeted a Hough transformation track finding step on GPUs and established a low-latency RDMA connection using the PCIe bus. To showcase the benefits of floating point operations, made possible by the use of GPUs, we present a modified algorithm. It uses hexagonal bins for the parameter space and leads to a more truthful representation of the possible track parameters of the individual hits in Hough space. This leads to fewer duplicate candidates and reduces fake track candidates compared to the regular approach. With data-transfer latencies of 2 μs and processing times for the Hough transformation as low as 3.6 μs, we can show that latencies are not as critical as expected. However, computing throughput proves to be challenging due to hardware limitations.

  10. High throughput fingerprint analysis of large-insert clones.

    PubMed

    Marra, M A; Kucaba, T A; Dietrich, N L; Green, E D; Brownstein, B; Wilson, R K; McDonald, K M; Hillier, L W; McPherson, J D; Waterston, R H

    1997-11-01

    As part of the Human Genome Project, the Washington University Genome Sequencing Center has commenced systematic sequencing of human chromsome 7. To organize and supply the effort, we have undertaken the construction of sequence-ready physical maps for defined chromosomal intervals. Map construction is a serial process composed of three main activities. First, candidate STS-positive large-insert PAC and BAC clones are identified. Next, these candidate clones are subjected to fingerprint analysis. Finally, the fingerprint data are used to assemble sequence-ready maps. The fingerprinting method we have devised is key to the success of the overall approach. We present here the details of the method and show that the fingerprints are of sufficient quality to permit the construction of megabase-size contigs in defined regions of the human genome. We anticipate that the high throughput and precision characteristic of our fingerprinting method will make it of general utility.

  11. Detector Developments for the High Luminosity LHC Era (2/4)

    ScienceCinema

    None

    2016-07-12

    Calorimetry and Muon Spectromers - Part II: When upgrading the LHC to higher luminosities, the detector and trigger performance shall be preserved - if not improved - with respect to the nominal performance. The ongoing R&D; for new radiation tolerant front-end electronics for calorimeters with higher read-out bandwidth are summarized and new possibilities for the trigger systems are presented. Similar developments are foreseen for the muon spectrometers, where also radiation tolerance of the muon detectors and functioning at high background rates is important. The corresponding plans and research work for the calorimeter and muon detectors at a LHC with highest luminsity are presented.

  12. Development of planar pixel modules for the ATLAS high luminosity LHC tracker upgrade

    NASA Astrophysics Data System (ADS)

    Allport, P. P.; Ashby, J.; Bates, R. L.; Blue, A.; Burdin, S.; Buttar, C. M.; Casse, G.; Dervan, P.; Doonan, K.; Forshaw, D.; Lipp, J.; McMullen, T.; Pater, J.; Stewart, A.; Tsurin, I.

    2014-11-01

    The high-luminosity LHC will present significant challenges for tracking systems. ATLAS is preparing to upgrade the entire tracking system, which will include a significantly larger pixel detector. This paper reports on the development of large area planar detectors for the outer pixel layers and the pixel endcaps. Large area sensors have been fabricated and mounted onto 4 FE-I4 readout ASICs, the so-called quad-modules, and their performance evaluated in the laboratory and testbeam. Results from characterisation of sensors prior to assembly, experience with module assembly, including bump-bonding and results from laboratory and testbeam studies are presented.

  13. Studies of helium based drift chamber gases for high-luminosity low energy machines

    NASA Astrophysics Data System (ADS)

    Boyarski, A.; Briggs, D.; Burchat, P. R.

    1992-02-01

    Future high luminosity low energy machines will need low mass tracking chambers in order to minimize multiple scattering of the relatively low momentum tracks produced at these facilities. A drift chamber using a helium based gas rather than a conventional argon based gas would greatly reduce the amount of multiple scattering. This paper summarizes measurements of the drift velocity and position resolution for gas mixtures of helium with CO2 and isobutane and helium with DME. Good spatial resolutions are obtained. A design of a drift chamber with only 0.12 percent of a radiation length (gas plus wire) over a 60 cm tracking distance is presented.

  14. Studies of helium based drift chamber gases for high-luminosity low energy machines

    NASA Astrophysics Data System (ADS)

    Boyarski, Adam; Briggs, Don; Burchat, Patricia R.

    1992-12-01

    Future high luminosity low energy machines will need low mass tracking chambers in order to minimize multiple scattering of the relatively low momentum tracks produced at these facilities. A drift chamber using a helium based gas rather than a conventional argon based gas would greatly reduce the amount of multiple scattering. This paper summarizes measurements of the drift velocity and position resolution for gas mixtures of helium with CO 2 and isobutane and helium with DME. Good spatial resolutions are obtained. A design of a drift chamber with only 0.12% of a radiation length (gas plus wire) over a 60 cm tracking distance is presented.

  15. PROBING THE WARM DARK MATTER WITH THE HIGH-z QUASAR LUMINOSITY FUNCTION

    SciTech Connect

    Song, Hyunmi; Lee, Jounghun

    2009-09-20

    In a warm dark matter (WDM) cosmology, the first objects to form at z >= 20 are one-dimensional filaments with mean length on the order of the WDM free-streaming scale. Gao and Theuns recently claimed by using high-resolution hydrodynamic simulations that the eventual collapse of these WDM filaments along their longest axes may seed the supermassive black holes that power high-z quasars. In this picture, it is supposed that the high-z quasar luminosity function should reflect how abundant the WDM filaments are in the early universe. We derive analytically the mass function of early-universe filaments with the help of the Zel'dovich approximation. Then, we determine the rate of its decrease in the mass section corresponding to the free-streaming scale of a WDM particle of mass m {sub n}u. Adjusting the value of m{sub n}u, we fit the slope of the analytic model to that of the high-z quasar luminosity function measured from the Sloan Digital Sky Survey DR3. A new WDM constraint from this feasibility study is found to be consistent with the lightest super-symmetric partner.

  16. Ultra-high-energy cosmic rays from low-luminosity active galactic nuclei

    NASA Astrophysics Data System (ADS)

    Duţan, Ioana; Caramete, Laurenţiu I.

    2015-03-01

    We investigate the production of ultra-high-energy cosmic ray (UHECR) in relativistic jets from low-luminosity active galactic nuclei (LLAGN). We start by proposing a model for the UHECR contribution from the black holes (BHs) in LLAGN, which present a jet power Pj ⩽1046 erg s-1. This is in contrast to the opinion that only high-luminosity AGN can accelerate particles to energies ⩾ 50 EeV. We rewrite the equations which describe the synchrotron self-absorbed emission of a non-thermal particle distribution to obtain the observed radio flux density from sources with a flat-spectrum core and its relationship to the jet power. We found that the UHECR flux is dependent on the observed radio flux density, the distance to the AGN, and the BH mass, where the particle acceleration regions can be sustained by the magnetic energy extraction from the BH at the center of the AGN. We use a complete sample of 29 radio sources with a total flux density at 5 GHz greater than 0.5 Jy to make predictions for the maximum particle energy, luminosity, and flux of the UHECRs from nearby AGN. These predictions are then used in a semi-analytical code developed in Mathematica (SAM code) as inputs for the Monte-Carlo simulations to obtain the distribution of the arrival direction at the Earth and the energy spectrum of the UHECRs, taking into account their deflection in the intergalactic magnetic fields. For comparison, we also use the CRPropa code with the same initial conditions as for the SAM code. Importantly, to calculate the energy spectrum we also include the weighting of the UHECR flux per each UHECR source. Next, we compare the energy spectrum of the UHECRs with that obtained by the Pierre Auger Observatory.

  17. High-frequency thresholds: circumaural earphone versus insert earphone.

    PubMed

    Valente, M; Valente, M; Goebel, J

    1992-11-01

    Benefits of high-frequency audiometry in monitoring hearing sensitivity of patients administered ototoxic medications are well established. High-frequency thresholds have been reported to be variable, due in part to small differences in the placement of the earphone diaphragm over the opening of the ear canal. Reliability may be improved by using insert earphones (ER-2) when obtaining high-frequency thresholds. The purposes of this study were to determine high-frequency threshold test-retest reliability using Koss HV/1A+ and ER-2 earphones and to determine if significant differences are present between high-frequency thresholds obtained using these two earphones. Results obtained on 40 ears of 20 normal hearing adults revealed that differences between the test and retest thresholds for each earphone were not significant. Intrasubject threshold differences between the test and retest thresholds for each earphone were, for the most part, within +/- 10 dB at all test frequencies. Further, significantly greater intensity was required to measure threshold when using the ER-2 earphone when compared to the Koss HV/1A+ at all test frequencies.

  18. Indirect searches for sterile neutrinos at a high-luminosity Z-factory

    NASA Astrophysics Data System (ADS)

    Abada, A.; De Romeri, V.; Monteil, S.; Orloff, J.; Teixeira, A. M.

    2015-04-01

    A future high-luminosity Z-factory will offer the possibility to study rare Z decays, as those leading to lepton flavour violating final states. Processes such as Z → ℓ {1/∓} ℓ {2/±} are potentially complementary to low-energy (high-intensity) observables of lepton flavour violation. In this work we address the impact of new sterile fermions on lepton flavour violating Z decays, focusing on potential searches at FCC-ee (TLEP), and taking into account experimental and observational constraints on the sterile states. We consider a minimal extension of the Standard Model by one sterile fermion state, and two well-motivated frameworks of neutrino mass generation, the Inverse Seesaw embedded into the Standard Model, and the νMSM. Our study shows that sterile neutrinos can give rise to contributions to BR( Z → ℓ {1/∓} ℓ {2/±}) within reach of the FCC-ee. We also discuss the complementarity between a high-luminosity Z-factory and low-energy charged lepton flavour violation facilities.

  19. Genome ARTIST: a robust, high-accuracy aligner tool for mapping transposon insertions and self-insertions.

    PubMed

    Ecovoiu, Alexandru Al; Ghionoiu, Iulian Constantin; Ciuca, Andrei Mihai; Ratiu, Attila Cristian

    2016-01-01

    A critical topic of insertional mutagenesis experiments performed on model organisms is mapping the hits of artificial transposons (ATs) at nucleotide level accuracy. Mapping errors may occur when sequencing artifacts or mutations as single nucleotide polymorphisms (SNPs) and small indels are present very close to the junction between a genomic sequence and a transposon inverted repeat (TIR). Another particular item of insertional mutagenesis is mapping of the transposon self-insertions and, to our best knowledge, there is no publicly available mapping tool designed to analyze such molecular events. We developed Genome ARTIST, a pairwise gapped aligner tool which works out both issues by means of an original, robust mapping strategy. Genome ARTIST is not designed to use next-generation sequencing (NGS) data but to analyze ATs insertions obtained in small to medium-scale mutagenesis experiments. Genome ARTIST employs a heuristic approach to find DNA sequence similarities and harnesses a multi-step implementation of a Smith-Waterman adapted algorithm to compute the mapping alignments. The experience is enhanced by easily customizable parameters and a user-friendly interface that describes the genomic landscape surrounding the insertion. Genome ARTIST is functional with many genomes of bacteria and eukaryotes available in Ensembl and GenBank repositories. Our tool specifically harnesses the sequence annotation data provided by FlyBase for Drosophila melanogaster (the fruit fly), which enables mapping of insertions relative to various genomic features such as natural transposons. Genome ARTIST was tested against other alignment tools using relevant query sequences derived from the D. melanogaster and Mus musculus (mouse) genomes. Real and simulated query sequences were also comparatively inquired, revealing that Genome ARTIST is a very robust solution for mapping transposon insertions. Genome ARTIST is a stand-alone user-friendly application, designed for high

  20. Sparse Representation for Signal Reconstruction in Calorimeters Operating in High Luminosity

    NASA Astrophysics Data System (ADS)

    Barbosa, Davis P.; de A. Filho, Luciano M.; Peralva, Bernardo S.; Cerqueira, Augusto S.; de Seixas, José M.

    2017-07-01

    A calorimeter signal reconstruction method, based on sparse representation (SR) of redundant data, is proposed for energy reconstruction in particle colliders operating in high-luminosity conditions. The signal overlapping is first modeled as an underdetermined linear system, leading to a convex set of feasible solutions. The solution with the smallest number of superimposed signals (the SR) that represents the recorded data is obtained through the use of an interior-point (IP) optimization procedure. From a signal processing point-of-view, the procedure performs a source separation, where the information of the amplitude of each convoluted signal is obtained. In the simulation results, a comparison of the proposed method with standard signal reconstruction one was performed. For this, a toy Monte Carlo simulation was developed, focusing in calorimeter front-end signal generation only, where the different levels of pileup and signal-to-noise ratio were used to qualify the proposed method. The results show that the method may be competitive in high-luminosity environments.

  1. Influence on collective effects on the performance of high-luminosity colliders

    NASA Astrophysics Data System (ADS)

    Zisman, Michael S.

    1990-10-01

    The design of a high-luminosity electron-position collider to study B physics is a challenging task from many points of view. In this paper we consider the influence of collective effects on the machine performance; most of our findings are ``generic,'' in the sense that they depend rather weakly on the details of the machine design. Both single-bunch and coupled-bunch instabilities are described and their effects are estimated based upon an example machine design (APIARY-IV). In addition, we examine the possibility of emittance growth from intrabeam scattering and calculate the beam lifetime from both Touschek and gas scattering. We find that the single-bunch instabilities should not lead to difficulty, and that the emittance growth is essentially negligible. At a background gas pressure of 10 nTorr, beam lifetimes of only a few hours are expected. Multibunch growth rates are very severe, even when using an optimized RF system consisting of single-cell, room-temperature RF cavities with geometrical shapes typical of superconducting cavities. Thus, a powerful feedback system will be required. In terms of collective effects, it does not appear that there are any fundamental problems standing in the way of successfully designing and building a high-luminosity B factory.

  2. Influence on collective effects on the performance of high-luminosity colliders

    SciTech Connect

    Zisman, M.S. )

    1990-10-10

    The design of a high-luminosity electron-position collider to study B physics is a challenging task from many points of view. In this paper we consider the influence of collective effects on the machine performance; most of our findings are generic,'' in the sense that they depend rather weakly on the details of the machine design. Both single-bunch and coupled-bunch instabilities are described and their effects are estimated based upon an example machine design (APIARY-IV). In addition, we examine the possibility of emittance growth from intrabeam scattering and calculate the beam lifetime from both Touschek and gas scattering. We find that the single-bunch instabilities should not lead to difficulty, and that the emittance growth is essentially negligible. At a background gas pressure of 10 nTorr, beam lifetimes of only a few hours are expected. Multibunch growth rates are very severe, even when using an optimized RF system consisting of single-cell, room-temperature RF cavities with geometrical shapes typical of superconducting cavities. Thus, a powerful feedback system will be required. In terms of collective effects, it does not appear that there are any fundamental problems standing in the way of successfully designing and building a high-luminosity B factory.

  3. Influence of collective effects on the performance of high-luminosity colliders

    SciTech Connect

    Zisman, M.S. )

    1990-05-25

    The design of a high-luminosity electron-positron collider to study B physics is a challenging task from many points of view. In this paper we consider the influence of collective effects on the machine performance; most of our findings are generic,'' in the sense that they depend rather weakly on the details of the machine design. Both single-bunch and coupled-bunch instabilities are described and their effects are estimated based upon an example machine design (APIARY-IV). In addition, we examine the possibility of emittance growth from intrabeam scattering and calculate the beam lifetime from both Touschek and gas scattering. We find that the single-bunch instabilities should not lead to difficulty, and that the emittance growth is essentially negligible. At a background gas pressure of 10 nTorr, beam lifetimes of only a few hours are expected. Multibunch growth rates are very severe, even when using an optimized RF system consisting of single-cell, room-temperature RF cavities with geometrical shapes typical of superconducting cavities. Thus, a powerful feedback system will be required. In terms of collective effects, it does not appear that there are any fundamental problems standing in the way of successfully designing and building a high-luminosity B factory. 15 refs., 21 figs., 5 tabs.

  4. Matching into the Helical Bunch Coalescing Channel for a High Luminosity Muon Collider

    SciTech Connect

    Sy, Amy; Ankenbrandt, Charles; Derbenev, Yaroslav; Morozov, Vasiliy; Neuffer, David; Yonehara, Katsuya; Yoshikawa, Cary; Johnson, R. P.

    2015-09-01

    For high luminosity in a muon collider, muon bunches that have been cooled in the six-dimensional helical cooling channel (HCC) must be merged into a single bunch and further cooled in preparation for acceleration and transport to the collider ring. The helical bunch coalescing channel has been previously simulated and provides the most natural match from helical upstream and downstream subsystems. This work focuses on the matching from the exit of the multiple bunch HCC into the start of the helical bunch coalescing channel. The simulated helical matching section simultaneously matches the helical spatial period lambda in addition to providing the necessary acceleration for efficient bunch coalescing. Previous studies assumed that the acceleration of muon bunches from p=209.15 MeV/c to 286.816 MeV/c and matching of lambda from 0.5 m to 1.0 m could be accomplished with zero particle losses and zero emittance growth in the individual bunches. This study demonstrates nonzero values for both particle loss and emittance growth, and provides considerations for reducing these adverse effects to best preserve high luminosity.

  5. The Host Galaxies of High-Luminosity Obscured Quasars at 2.5

    NASA Astrophysics Data System (ADS)

    Ross, Nicholas; Strauss, M. A.; Greene, J. E.; Zakamska, N. L.; Brandt, W. N.; Alexandroff, R.; Liu, G.; Smith, P. S.; The SDSS-III BOSS Quasar Working Group

    2014-01-01

    Active Galactic Nuclei play a key role in the evolution of galaxies. However, very little is known about the host galaxies of the most luminous quasars at redshift 2.5, the epoch when massive black hole growth peaked. The brightness of the quasar itself, which can easily outshine a galaxy by a large factor, makes it very difficult to study emission from extended gas or stars in the host galaxy. However, we have imaged the extended emission from the host galaxies of a unique sample of six optically extinguished (Type II) luminous quasars with 2.5, with the Hubble Space Telescope (Cycle 20, GO 13014) using ACS/F814W to access the rest-frame near-ultraviolet, and WFC3/F160W for the rest-frame optical longward of 4000A. These objects are selected from the spectroscopic database of the SDSS/Baryon Oscillation Spectroscopic Survey to have strong, narrow emission lines and weak continua. With these images, we have quantified the luminosity, morphology, and dynamical state of the host galaxies, and searched for extended scattered light from the obscured central engine. These observations are the first comprehensive study of both host galaxy light and scattered light in high-luminosity quasars at the epoch of maximum black hole growth, and give insights into the relationship between host galaxies and black holes during this important, and yet largely unexplored period.

  6. Soft X-ray spectral observations of quasars and high X-ray luminosity Seyfert galaxies

    NASA Technical Reports Server (NTRS)

    Petre, R.; Mushotzky, R. F.; Krolik, J. H.; Holt, S. S.

    1983-01-01

    Results of the analysis of 28 Einstein SSS observations of 15 high X-ray luminosity (L(x) 10 to the 435 power erg/s) quasars and Seyfert type 1 nuclei are presented. The 0.75-4.5 keV spectra are in general well fit by a simple model consisting of a power law plus absorption by cold gas. The averager spectral index alpha is 0.66 + or - .36, consistent with alpha for the spectrum of these objects above 2 keV. In all but one case, no evidence was found for intrinsic absorption, with an upper limit of 2 x 10 to the 21st power/sq cm. Neither was evidence found for partial covering of the active nucleus by dense, cold matter (N(H) 10 to the 22nd power/sq cm; the average upper limit on the partial covering fraction is 0.5. There is no obvious correlation between spectral index and 0175-4.5 keV X-ray luminosity (which ranges from 3 x 10 to the 43rd to 47th powers erg/s or with other source properties. The lack of intrinsic X-ray absorption allows us to place constraints on the density and temperature of the broad-line emission region, and narrow line emission region, and the intergalactic medium.

  7. Results of FE65-P2 Stability Tests for the High Luminosity LHC Upgrade

    NASA Astrophysics Data System (ADS)

    Dunne, Katherine; Atlas Collaboration

    2017-01-01

    The high luminosity upgrade of the LHC sets an imperative for readout technology capable of handling the consequences of higher particle interaction rates. Increased luminosity exists hand-in-hand with unprecedented levels of radiation and the need for exceptional logic density to store hit information during a trigger latency period on the order of 10 μs. The RD53 collaboration has developed specifications for the new generation of hybrid pixel readout chips to be included in the ATLAS and CMS Phase 2 upgrades. The FE65-P2 is a test readout chip fabricated on 65 nm CMOS technology that prototypes these design variants. Objectives of FE65-P2 include demonstrating the novel process of isolated analog front ends embedded in a digital design, known as ``analog islands in a digital sea.'' In addition, the innermost layer of the pixel detector in the upgraded ATLAS experiment will reach doses approaching 1 Mrad per run, and a single FE65-P2 should be tolerant to a lifetime dose near 500 Mrad. This talk will cover the test results of FE65-P2 calibration and stability. The experience gained from such tests will advise the development of RD53A, a large format readout chip to be fabricated in early 2017.

  8. Design and testing of a four rod crab cavity for High Luminosity LHC

    NASA Astrophysics Data System (ADS)

    Hall, B.; Burt, G.; Apsimon, R.; Lingwood, C. J.; Tutte, A.; Grudiev, A.; Macpherson, A.; Navarro-Tapia, M.; Calaga, R.; Hernández-Chahín, K. G.; Appleby, R. B.; Goudket, P.

    2017-01-01

    A 4-rod deflecting structure is proposed as a possible crab cavity design for the LHC high luminosity upgrade. Crab cavities are required for the LHC luminosity upgrade to provide a greater bunch overlap in the presence of a crossing angle, but must fit in the existing limited space. The structure has two parallel sections consisting of two longitudinally opposing quarter-wave rods, where each rod has the opposite charge from each of its nearest neighbors. The structure is transversely compact because the frequency is dependent on the rod lengths rather than the cavity radius. Simulations were undertaken to investigate the effect of rod shape on surface fields, higher order multipole terms and induced wakefields in order to obtain the optimal rod shape. The simulation results presented show that the addition of focus electrodes or by shaping the rods the sextupole contribution of the cavity voltage can be negated; the sextupole contribution is 321.57 mTm /m2 , Epeak=27.7 MV /m , and Bpeak=63.9 mT at the design voltage of 3 MV. The damping requirements for the LHC are critical and suitable couplers to damp all modes but the operating mode are presented. The results of various testing cycles of the first SRF 4 rod prototype cavity are presented and show that the cavity has reached the required transverse voltage of 3 MV.

  9. Research and development for a free-running readout system for the ATLAS LAr Calorimeters at the high luminosity LHC

    NASA Astrophysics Data System (ADS)

    Hils, Maximilian; Atlas Liquid Argon Calorimeter Group

    2016-07-01

    The ATLAS Liquid Argon (LAr) Calorimeters were designed and built to measure electromagnetic and hadronic energy in proton-proton collisions produced at the Large Hadron Collider (LHC) at centre-of-mass energies up to 14 TeV and instantaneous luminosities up to 1034 cm-2 s-1. The High Luminosity LHC (HL-LHC) programme is now developed for up to 5-7 times the design luminosity, with the goal of accumulating an integrated luminosity of 3000 fb-1. In the HL-LHC phase, the increased radiation levels and an improved ATLAS trigger system require a replacement of the Front-end (FE) and Back-end (BE) electronics of the LAr Calorimeters. Results from research and development of individual components and their radiation qualification as well as the overall system design will be presented.

  10. Exploring the Standard Model with the High Luminosity, Polarized Electron-Ion Collider

    SciTech Connect

    Milner, Richard G.

    2009-08-04

    The Standard Model is only a few decades old and has been successfully confirmed by experiment, particularly at the high energy frontier. This will continue with renewed vigor at the LHC. However, many important elements of the Standard Model remain poorly understood. In particular, the exploration of the strong interaction theory Quantum Chromodynamics is in its infancy. How does the spin-1/2 of the proton arise from the fundamental quark and gluon constituents? Can we understand the new QCD world of virtual quarks and gluons in the nucleon? Using precision measurements can we test the limits of the Standard Model and look for new physics? To address these and other important questions, physicists have developed a concept for a new type of accelerator, namely a high luminosity, polarized electron-ion collider. Here the scientific motivation is summarized and the accelerator concepts are outlined.

  11. A readout driver for the ATLAS LAr-calorimeter at a High Luminosity LHC

    NASA Astrophysics Data System (ADS)

    Kielburg-Jeka, A.; Stärz, S.

    2011-01-01

    A new readout driver (ROD) is being developed as a central part of the signal processing of the ATLAS liquid-argon calorimeters for operation at the High Luminosity LHC (HL-LHC). In the architecture of the upgraded readout system, the ROD modules will have several challenging tasks: receiving of up to 1.4 Tb/s of data per board from the detector front-end on multiple high-speed serial links, low-latency data processing, data buffering, and data transmission to the ATLAS trigger and DAQ systems. In order to evaluate the different components, prototype boards in ATCA format equipped with modern Xilinx and Altera FPGAs have been built. We will report on the measured performance of the SERDES devices, the parallel signal processing using DSP slices, the implementation of trigger interfaces, using e.g. multi-Gb Ethernet, as well as the development of the ATCA infrastructure on the very first ROD prototype modules.

  12. Changes to the Transfer Line Collimation System for the High-Luminosity LHC Beams

    SciTech Connect

    Kain, V.; Aberle, O.; Bracco, C.; Fraser, M.; Galleazzi, F.; Gianfelice-Wendt, E.; Kosmicki, A.; Maciariello, F.; Meddahi, M.; Nuiry, F. X.; Steele, G.; Velotti, F.

    2015-06-01

    The current LHC transfer line collimation system will not be able to provide enough protection for the high brightness beams in the high-luminosity LHC era. The new collimation system will have to attenuate more and be more robust than its predecessor. The active jaw length of the new transfer line collimators will therefore be 2.1 m instead of currently 1.2 m. The transfer line optics will have to be adjusted for the new collimator locations and larger beta functions at the collimators for absorber robustness reasons. In this paper the new design of the transfer line collimation system will be presented with its implications on transfer line optics and powering, maintainability, protection of transfer line magnets in case of beam loss on a collimator and protection of the LHC aperture.

  13. A readout driver for the ATLAS LAr-calorimeter at a High Luminosity LHC

    NASA Astrophysics Data System (ADS)

    Kielburg-Jeka, A.; Stärz, S.

    2011-01-01

    A new readout driver (ROD) is being developed as a central part of the signal processing of the ATLAS liquid-argon calorimeters for operation at the High Luminosity LHC (HL-LHC). In the architecture of the upgraded readout system, the ROD modules will have several challenging tasks: receiving of up to 1.4 Tb/s of data per board from the detector front-end on multiple high-speed serial links, low-latency data processing, data buffering, and data transmission to the ATLAS trigger and DAQ systems. In order to evaluate the different components, prototype boards in ATCA format equipped with modern Xilinx and Altera FPGAs have been built. We will report on the measured performance of the SERDES devices, the parallel signal processing using DSP slices, the implementation of trigger interfaces, using e.g. multi-Gb Ethernet, as well as the development of the ATCA infrastructure on the very first ROD prototype modules.

  14. A high-redshift IRAS galaxy with huge luminosity - Hidden quasar or protogalaxy?

    NASA Technical Reports Server (NTRS)

    Rowan-Robinson, M.; Broadhurst, T.; Oliver, S. J.; Taylor, A. N.; Lawrence, A.; Mcmahon, R. G.; Lonsdale, C. J.; Hacking, P. B.; Conrow, T.

    1991-01-01

    An emission line galaxy with the enormous far-IR luminosity of 3 x 10 to the 14th solar has been found at z = 2.286. The spectrum is very unusual, showing lines of high excitation but with very weak Lyman-alpha emission. A self-absorbed synchrotron model for the IR energy distribution cannot be ruled out, but a thermal origin seems more plausible. A radio-quiet quasar embedded in a very dusty galaxy could account for the IR emission, as might a starburst embedded in 1-10 billion solar masses of dust. The latter case demands so much dust that the object would probably be a massive galaxy in the process of formation. The presence of a large amount of dust in an object of such high redshift implies the generation of heavy elements at an early cosmological epoch.

  15. FLUKA studies of hadron-irradiated scintillating crystals for calorimetry at the High-Luminosity LHC

    NASA Astrophysics Data System (ADS)

    Quittnat, Milena; CMS Collaboration

    2015-02-01

    Calorimetry at the High-Luminosity LHC (HL-LHC) will be performed in a harsh radiation environment with high hadron fluences. The upgraded CMS electromagnetic calorimeter design and suitable scintillating materials are a focus of current research. In this paper, first results using the Monte Carlo simulation program FLUKA are compared to measurements performed with proton-irradiated LYSO, YSO and cerium fluoride crystals. Based on these results, an extrapolation to the behavior of an electromagnetic sampling calorimeter, using one of the inorganic scintillators above as an active medium, is performed for the upgraded CMS experiment at the HL-LHC. Characteristic parameters such as the induced ambient dose, fluence spectra for different particle types and the residual nuclei are studied, and the suitability of these materials for a future calorimeter is surveyed. Particular attention is given to the creation of isotopes in an LYSO-tungsten calorimeter that might contribute a prohibitive background to the measured signal.

  16. High Luminosity Options for the JLC.NLC at 500 GeV cms(LCC-0004)

    SciTech Connect

    Raubenheimer, T

    2004-04-22

    The present JLC/NLC parameters are chosen to provide luminosities between 0.5 {approx} 0.75 x 10{sup 34} s{sup -1} cm{sup -2} at a cms energy of 500 GeV; the parameters are listed in Table 1 for both the 500 GeV and 1 TeV cases. In all cases, these luminosities assume extensive margins and emittance dilutions to ensure that they are attainable. In this note, they consider the feasibility of substantially higher luminosities which might be attained by operating with smaller emittance dilutins and higher beam currents. The parameters they describe are listed in Table 2 where these high luminosity sets (ILC-IHa and ILC-IHb) are compared with the base JLC/NLC set (ILC-Ib) and with the high luminosity TESLA parameter set. In the next sections, they will discuss the limitations and assumptions leading to these higher luminosity parameter sets. The details in their discussion will be based on the NLC design described in the Zeroth-order Design Report (ZDR) but the same arguments, with slightly different values, could be applied to the JLC reference design.

  17. The High-Redshift Quasar Luminosity Function from Multi-Epoch Imaging Surveys

    NASA Astrophysics Data System (ADS)

    AlSayyad, Yusra

    Upcoming time-domain imaging surveys such as the LSST will detect over a million high-redshift z > 4 quasars, making complete spectroscopic followup unfeasible. Statistical estimates such as luminosity functions and clustering measurements will require purely photometric methods for classifying quasars, estimating redshifts and estimating selection functions. We validate these methods and constrain the optical, type I quasar luminosity function (QLF) at 3.75 < z < 4.5 for -27.5 < M1450 3.75) and constraint on the characteristic luminosity (M*1450 = -26.7) from a single, uniformly-selected survey at z 4. We used the Sloan Digital Sky Survey (SDSS) repeated imaging of the 275 sq. deg. equatorial region of the sky (-50 < R.A. < +60; -1.26 < Dec. < +1.26), known as Stripe 82, to select a statistical sample of z 4 quasars. We extracted 40 million lightcurves from the imaging using forced photometry on all u, g, r, i, z epochs at the positions of sources detected on a deep i-band co-add. We developed a classification method based on photometric information alone (colors and variability metrics derived from these new multi-band lightcurves), which we validated with a spectroscopically complete 55 sq. deg. sub-region augmented with 102 new spectroscopic observations of quasars at z > 3.4 with i < 22.5. We demonstrate that selection functions for ensemble classifiers can be estimated by building generative models of empirical distributions of quasars previously selected with a diverse set of selection criteria. The z 4 QLF contributes to our understanding of supermassive black hole growth and cosmic reionization of both H I and He II which likely began at z 4 as a result of hard UV emissivity from quasars. The resulting QLF measurement is consistent with the previous lower number densities reported from deep, narrow-field surveys (COSMOS); it is not consistent with higher number densities reported from the NDWFS-DLS and CANDELS GOODS-S fields. In the context of recent 2

  18. Gas related effects on multi-gap RPC performance in high luminosity experiments

    NASA Astrophysics Data System (ADS)

    Lyu, P.; Wang, Y.; Guo, B.; Han, D.; Xie, B.; Li, Y.; Wang, F.

    2016-11-01

    The Multi-gap Resistive Plate Chamber (MRPC) is a new type of gas detector developed in recent years. It has excellent time resolution (better than 100 ps) and high efficiency (higher than 95%). This detector has been used to construct large-area time-of-flight (TOF) system in many nuclear and particle physics experiments. However, as a type of gaseous detector, the aging of the gas mixture under long-time exposure to ionizing radiation cannot be neglected. With the increase of accelerator luminosity, impurities in the gas mixture can be potentially dangerous for long-term operation of the MRPC. This has been observed in some experiments, for example with the RHIC-STAR muon telescope detector. The CBM-TOF, used for hadron identification, is proposed to be assembled with MRPCs. These counters have to stand particle fluxes as high as 25 kHz/cm2, and thus the gas pollution is a critical aspect to be studied. In order to better understand the gas quality's impact on the MRPC performance, a two-dimensional simulation based on the SIMPLE algorithm is carried out to imitate the distribution of impurities in a MRPC gas box. The preliminary results show that gas pollution grows stronger with the increase of the gas-flowing volume. In addition, we conducted a series of experiments with a 50 × 50 cm2, 8-gap MRPC prototype. The results match the simulation quite well. Gas pollution indeed has a severe impact on the MRPC performance, and further study can be very useful to reduce gas aging effects in high-luminosity experiments.

  19. High-eccentric X-ray binaries: evolution, wind rose effect, accretor-propeller luminosity gap

    NASA Astrophysics Data System (ADS)

    Raguzova, Natalya V.; Lipunov, Vladimir M.

    1998-12-01

    The influence of the spatial distribution of stellar wind velocities (Wind Rose effect) on the X-ray light curve of highly eccentric binaries is examined using the properties of spherical-symmetrical and Be disk-fed outflow. The effects of the wind geometry, velocities and densities in the stellar wind of the Be star and of the orbital motion of the neutron star on the expected X-ray luminosity are investigated. It is shown that the shapes of the X-ray light curves depend strongly on the outflow velocity of the gas ejected by the Be star at the orbital distance of the compact object. If vwind << vorb then the X-ray luminosity is high and the X-ray light curves are determined by the orbital velocity of the neutron star. The effects of changes in the mass loss rate of the Be star and in the orbital separation on the expected X-ray light curves are studied. It is shown that a phase shift of the maximum X-ray luminosity is always present in the X-ray light curves. We show that in some cases an accretion disk may temporarily form around the neutron star. The observed X-ray light curves of some transient binaries are analysed using the developed model. We show that the Be/X-ray transients A 0538-66, X 0331+53 and some other sources are likely to undergo transitions from the accreting neutron star regime to the propelling one. Evolutionary scenarios which can lead to a formation of the binary systems A 0538-66, A 0535+26, X 0331+53, 4U 1145-619, 4U 0115+634 and EXO 2030+375 are presented. For the first time, the evolutionary tracks include both the orbital period changes and the neutron star spin period history. Using Monte Carlo simulations, we calculate the number distributions of Be+X-ray PSR binaries over orbital periods and eccentricities for different scenario parameters taking into consideration the influence of kick velocity and synchronization. We conclude that synchronization is a very important process and must be taken into account when calculating Be star

  20. High-Luminosity Blue and Blue-Green Gallium Nitride Light-Emitting Diodes

    NASA Astrophysics Data System (ADS)

    Morkoc, H.; Mohammad, S. N.

    1995-01-01

    Compact and efficient sources of blue light for full color display applications and lighting eluded and tantalized researchers for many years. Semiconductor light sources are attractive owing to their reliability and amenability to mass manufacture. However, large band gaps are required to achieve blue color. A class of compound semiconductors formed by metal nitrides, GaN and its allied compounds AlGaN and InGaN, exhibits properties well suited for not only blue and blue-green emitters, but also for ultraviolet emitters and detectors. What thwarted engineers and scientists from fabricating useful devices from these materials in the past was the poor quality of material and lack of p-type doping. Both of these obstacles have recently been overcome to the point where high-luminosity blue and blue-green light-emitting diodes are now available in the marketplace.

  1. Simulations of a fast feedback system for the High Luminosity LHC

    NASA Astrophysics Data System (ADS)

    Daw, Aron; Mastoridis, Themistoklis; Nguyen, Philippe

    2017-01-01

    The High-Luminosity LHC upgrade, expected to be finished by 2025, will generate a tenfold increase in the number of recorded collisions. Part of this improvement will come from the implementation of crab cavities, which exert transverse momentum kicks on the bunches of particles just before they collide, in order to have head-on collisions. The crab cavity field will include amplitude and phase noise, leading to undesirable consequences, such as the increase of the particle cloud size (emittance). Simulations were performed to evaluate the performance improvement with a proposed fast feedback system acting through the crab cavities. This work is supported by the National Science Foundation under Grant No. PHY-1535536.

  2. Models of stellar population at high redshift, as constrainedby PN yields and luminosity function

    NASA Astrophysics Data System (ADS)

    Maraston, C.

    The stellar phase of Thermally-Pulsating Asymptotic giant branch is the last major evolutionary stage of intermediate-mass stars which afterwards evolve into planetary nebulae. The TP-AGB phase is affected by mass-loss and instabilities which notoriously make its theoretical modelling uncertain. This review focuses on the effects such modelling has on stellar population models for galaxies, with particular focus on the high-z Universe where galaxies are young and contain a large number of short-living TP-AGB stars. I shall present the models, discuss how different prescriptions for the treatment of the TP-AGB affect the theoretical integrated spectral energy distribution and how these compare to galaxy data, and discuss implications for the PN nebulae luminosity function stemming from the various assumptions. Finally I shall discuss the inclusion of hot evolved stars on stellar population models and how they compare to data for old galaxies at our present time.

  3. THE FAINT END OF THE CLUSTER-GALAXY LUMINOSITY FUNCTION AT HIGH REDSHIFT

    SciTech Connect

    Mancone, Conor L.; Baker, Troy; Gonzalez, Anthony H.; Ashby, Matthew L. N.; Snyder, Greg; Stanford, Spencer A.; Brodwin, Mark; Eisenhardt, Peter R. M.; Stern, Daniel; Wright, Edward L.

    2012-12-20

    We measure the faint-end slope of the galaxy luminosity function (LF) for cluster galaxies at 1 < z < 1.5 using Spitzer IRAC data. We investigate whether this slope, {alpha}, differs from that of the field LF at these redshifts, and with the cluster LF at low redshifts. The latter is of particular interest as low-luminosity galaxies are expected to undergo significant evolution. We use seven high-redshift spectroscopically confirmed galaxy clusters drawn from the IRAC Shallow Cluster Survey to measure the cluster-galaxy LF down to depths of M* + 3 (3.6 {mu}m) and M* + 2.5 (4.5 {mu}m). The summed LF at our median cluster redshift (z = 1.35) is well fit by a Schechter distribution with {alpha}{sub 3.6{mu}m} = -0.97 {+-} 0.14 and {alpha}{sub 4.5{mu}m} = -0.91 {+-} 0.28, consistent with a flat faint-end slope and is in agreement with measurements of the field LF in similar bands at these redshifts. A comparison to {alpha} in low-redshift clusters finds no statistically significant evidence of evolution. Combined with past studies which show that M* is passively evolving out to z {approx} 1.3, this means that the shape of the cluster LF is largely in place by z {approx} 1.3. This suggests that the processes that govern the buildup of the mass of low-mass cluster galaxies have no net effect on the faint-end slope of the cluster LF at z {approx}< 1.3.

  4. Development of N+ in P pixel sensors for a high-luminosity large hadron collider

    NASA Astrophysics Data System (ADS)

    Kamada, Shintaro; Yamamura, Kazuhisa; Unno, Yoshinobu; Ikegami, Yoichi

    2014-11-01

    Hamamatsu Photonics K. K. is developing an N+ in a p planar pixel sensor with high radiation tolerance for the high-luminosity large hadron collider (HL-LHC). The N+ in the p planar pixel sensor is a candidate for the HL-LHC and offers the advantages of high radiation tolerance at a reasonable price compared with the N+ in an n planar sensor, the three-dimensional sensor, and the diamond sensor. However, the N+ in the p planar pixel sensor still presents some problems that need to be solved, such as its slim edge and the danger of sparks between the sensor and readout integrated circuit. We are now attempting to solve these problems with wafer-level processes, which is important for mass production. To date, we have obtained a 250-μm edge with an applied bias voltage of 1000 V. To protect against high-voltage sparks from the edge, we suggest some possible designs for the N+ edge.

  5. The Protostellar Luminosity Function

    NASA Astrophysics Data System (ADS)

    Offner, Stella S. R.; McKee, Christopher F.

    2011-07-01

    The protostellar luminosity function (PLF) is the present-day luminosity function of the protostars in a region of star formation. It is determined using the protostellar mass function in combination with a stellar evolutionary model that provides the luminosity as a function of instantaneous and final stellar mass. In 2010, McKee & Offner considered three main accretion models: the isothermal sphere (IS) model, the turbulent core (TC) model, and an approximation of the competitive accretion (CA) model. We also consider the effect of an accretion rate that tapers off linearly in time and an accelerating star formation rate. For each model, we characterize the luminosity distribution using the mean, median, maximum, ratio of the median to the mean, standard deviation of the logarithm of the luminosity, and the fraction of very low luminosity objects. We compare the models with bolometric luminosities observed in local star-forming regions and find that models with an approximately constant accretion time, such as the TC and CA models, appear to agree better with observation than those with a constant accretion rate, such as the IS model. We show that observations of the mean protostellar luminosity in these nearby regions of low-mass star formation suggest a mean star formation time of 0.3 ± 0.1 Myr. Such a timescale, together with some accretion that occurs non-radiatively and some that occurs in high-accretion, episodic bursts, resolves the classical "luminosity problem" in low-mass star formation, in which observed protostellar luminosities are significantly less than predicted. An accelerating star formation rate is one possible way of reconciling the observed star formation time and mean luminosity. Future observations will place tighter constraints on the observed luminosities, star formation time, and episodic accretion, enabling better discrimination between star formation models and clarifying the influence of variable accretion on the PLF.

  6. THE PROTOSTELLAR LUMINOSITY FUNCTION

    SciTech Connect

    Offner, Stella S. R.; McKee, Christopher F. E-mail: cmckee@astro.berkeley.edu

    2011-07-20

    The protostellar luminosity function (PLF) is the present-day luminosity function of the protostars in a region of star formation. It is determined using the protostellar mass function in combination with a stellar evolutionary model that provides the luminosity as a function of instantaneous and final stellar mass. In 2010, McKee and Offner considered three main accretion models: the isothermal sphere (IS) model, the turbulent core (TC) model, and an approximation of the competitive accretion (CA) model. We also consider the effect of an accretion rate that tapers off linearly in time and an accelerating star formation rate. For each model, we characterize the luminosity distribution using the mean, median, maximum, ratio of the median to the mean, standard deviation of the logarithm of the luminosity, and the fraction of very low luminosity objects. We compare the models with bolometric luminosities observed in local star-forming regions and find that models with an approximately constant accretion time, such as the TC and CA models, appear to agree better with observation than those with a constant accretion rate, such as the IS model. We show that observations of the mean protostellar luminosity in these nearby regions of low-mass star formation suggest a mean star formation time of 0.3 {+-} 0.1 Myr. Such a timescale, together with some accretion that occurs non-radiatively and some that occurs in high-accretion, episodic bursts, resolves the classical 'luminosity problem' in low-mass star formation, in which observed protostellar luminosities are significantly less than predicted. An accelerating star formation rate is one possible way of reconciling the observed star formation time and mean luminosity. Future observations will place tighter constraints on the observed luminosities, star formation time, and episodic accretion, enabling better discrimination between star formation models and clarifying the influence of variable accretion on the PLF.

  7. Elliptical Accretion and Low Luminosity from High Accretion Rate Stellar Tidal Disruption Events

    NASA Astrophysics Data System (ADS)

    Svirski, Gilad; Piran, Tsvi; Krolik, Julian

    2017-05-01

    Models for tidal disruption events (TDEs) in which a supermassive black hole disrupts a star commonly assume that the highly eccentric streams of bound stellar debris promptly form a circular accretion disc at the pericentre scale. However, the bolometric peak luminosity of most TDE candidates, ˜ 1044 erg s- 1, implies that we observe only ˜1 per cent of the energy expected from radiatively efficient accretion. Even the energy that must be lost to circularize the returning tidal flow is larger than the observed energy. Recently, Piran et al. suggested that the observed optical TDE emission is powered by shocks at the apocentre between freshly infalling material and earlier arriving matter. This model explains the small radiated energy, the low temperature and the large radius implied by the observations as well as the t-5/3 light curve. However the question of the system's low bolometric efficiency remains unanswered. We suggest that the high orbital energy and low angular momentum of the flow make it possible for magnetic stresses to reduce the matter's already small angular momentum to the point at which it can fall ballistically into the supermassive black hole before circularization. As a result, the efficiency is only ˜1-10 per cent of a standard accretion disc's efficiency. Thus, the intrinsically high eccentricity of the tidal debris naturally explains why most TDE candidates are fainter than expected.

  8. Elliptical Accretion and Low Luminosity from High Accretion Rate Stellar Tidal Disruption Events

    NASA Astrophysics Data System (ADS)

    Svirski, Gilad; Piran, Tsvi; Krolik, Julian

    2017-01-01

    Models for tidal disruption events (TDEs) in which a supermassive black hole disrupts a star commonly assume that the highly eccentric streams of bound stellar debris promptly form a circular accretion disk at the pericenter scale. However, the bolometric peak luminosity of most TDE candidates, ˜ 10^{44} {erg s^{-1}}, implies that we observe only ˜1% of the energy expected from radiatively efficient accretion. Even the energy that must be lost to circularize the returning tidal flow is larger than the observed energy. Recently, Piran et al. (2015) suggested that the observed optical TDE emission is powered by shocks at the apocenter between freshly infalling material and earlier arriving matter. This model explains the small radiated energy, the low temperature, and the large radius implied by the observations as well as the t-5/3 light curve. However the question of the system's low bolometric efficiency remains unanswered. We suggest that the high orbital energy and low angular momentum of the flow make it possible for magnetic stresses to reduce the matter's already small angular momentum to the point at which it can fall ballistically into the SMBH before circularization. As a result, the efficiency is only ˜1-10% of a standard accretion disk's efficiency. Thus, the intrinsically high eccentricity of the tidal debris naturally explains why most TDE candidates are fainter than expected.

  9. Controlling the electronic and geometric structures of 2D insertions to realize high performance metal/insertion-MoS2 sandwich interfaces.

    PubMed

    Su, Jie; Feng, Liping; Zeng, Wei; Liu, Zhengtang

    2017-06-08

    Metal/insertion-MoS2 sandwich interfaces are designed to reduce the Schottky barriers at metal-MoS2 interfaces. The effects of geometric and electronic structures of two-dimensional (2D) insertion materials on the contact properties of metal/insertion-MoS2 interfaces are comparatively studied by first-principles calculations. Regardless of the geometric and electronic structures of 2D insertion materials, Fermi level pinning effects and charge scattering at the metal/insertion-MoS2 interface are weakened due to weak interactions between the insertion and MoS2 layers, no gap states and negligible structural deformations for MoS2 layers. The Schottky barriers at metal/insertion-MoS2 interfaces are induced by three interface dipoles and four potential steps that are determined by the charge transfers and structural deformations of 2D insertion materials. The lower the electron affinities of 2D insertion materials, the more are the electrons lost from the Sc surface, resulting in lower n-type Schottky barriers at Sc/insertion-MoS2 interfaces. The larger the ionization potentials and the thinner the thicknesses of 2D insertion materials, the fewer are the electrons that accumulate at the Pt surface, leading to lower p-type Schottky barriers at Pt/insertion-MoS2 interfaces. All Sc/insertion-MoS2 interfaces exhibited ohmic characters. The Pt/BN-MoS2 interface exhibits the lowest p-type Schottky barrier of 0.52 eV due to the largest ionization potential (∼6.88 eV) and the thinnest thickness (single atomic layer thickness) of BN. These results in this work are beneficial to understand and design high performance metal/insertion-MoS2 interfaces through 2D insertion materials.

  10. Constraints on dark matter scenarios from measurements of the galaxy luminosity function at high redshifts

    NASA Astrophysics Data System (ADS)

    Corasaniti, P. S.; Agarwal, S.; Marsh, D. J. E.; Das, S.

    2017-04-01

    We use state-of-the-art measurements of the galaxy luminosity function (LF) at z =6 , 7, and 8 to derive constraints on warm dark matter (WDM), late-forming dark matter, and ultralight axion dark matter models alternative to the cold dark matter (CDM) paradigm. To this purpose, we have run a suite of high-resolution N -body simulations to accurately characterize the low-mass end of the halo mass function and derive dark matter (DM) model predictions of the high-z luminosity function. In order to convert halo masses into UV magnitudes, we introduce an empirical approach based on halo abundance matching, which allows us to model the LF in terms of the amplitude and scatter of the ensemble average star formation rate halo mass relation, ⟨SFR (Mh ,z )⟩, of each DM model. We find that, independent of the DM scenario, the average SFR at fixed halo mass increases from z =6 to 8, while the scatter remains constant. At halo mass Mh≳1012 M⊙ h-1 , the average SFR as a function of halo mass follows a double power law trend that is common to all models, while differences occur at smaller masses. In particular, we find that models with a suppressed low-mass halo abundance exhibit higher SFR compared to the CDM results. Thus, different DM models predict a different faint-end slope of the LF which causes the goodness of fit to vary within each DM scenario for different model parameters. Using deviance statistics, we obtain a lower limit on the WDM thermal relic particle mass, mWDM≳1.5 keV at 2 σ . In the case of LFDM models, the phase transition redshift parameter is bounded to zt≳8 ×105 at 2 σ . We find ultralight axion dark matter best-fit models with axion mass ma≳1.6 ×10-22 eV to be well within 2 σ of the deviance statistics. We remark that measurements at z =6 slightly favor a flattening of the LF at faint UV magnitudes. This tends to prefer some of the non-CDM models in our simulation suite, although not at a statistically significant level to distinguish

  11. Constraining the minimum luminosity of high redshift galaxies through gravitational lensing

    SciTech Connect

    Mashian, Natalie; Loeb, Abraham E-mail: aloeb@cfa.harvard.edu

    2013-12-01

    We simulate the effects of gravitational lensing on the source count of high redshift galaxies as projected to be observed by the Hubble Frontier Fields program and the James Webb Space Telescope (JWST) in the near future. Taking the mass density profile of the lensing object to be the singular isothermal sphere (SIS) or the Navarro-Frenk-White (NFW) profile, we model a lens residing at a redshift of z{sub L} = 0.5 and explore the radial dependence of the resulting magnification bias and its variability with the velocity dispersion of the lens, the photometric sensitivity of the instrument, the redshift of the background source population, and the intrinsic maximum absolute magnitude (M{sub max}) of the sources. We find that gravitational lensing enhances the number of galaxies with redshifts z∼> 13 detected in the angular region θ{sub E}/2 ≤ θ ≤ 2θ{sub E} (where θ{sub E} is the Einstein angle) by a factor of ∼ 3 and 1.5 in the HUDF (df/dν{sub 0} ∼ 9 nJy) and medium-deep JWST surveys (df/dν{sub 0} ∼ 6 nJy). Furthermore, we find that even in cases where a negative magnification bias reduces the observed number count of background sources, the lensing effect improves the sensitivity of the count to the intrinsic faint-magnitude cut-off of the Schechter luminosity function. In a field centered on a strong lensing cluster, observations of z∼> 6 and z∼> 13 galaxies with JWST can be used to infer this cut-off magnitude for values as faint as M{sub max} ∼ -14.4 and -16.1 mag (L{sub min} ≈ 2.5 × 10{sup 26} and 1.2 × 10{sup 27} erg s{sup −1} Hz{sup −1}) respectively, within the range bracketed by existing theoretical models. Gravitational lensing may therefore offer an effective way of constraining the low-luminosity cut-off of high-redshift galaxies.

  12. Radiological Environmental Protection for PEP-II Ring High Luminosity Operation

    SciTech Connect

    Liu, James C.; Nakao, Noriaki; /SLAC

    2006-08-16

    Stanford Linear Accelerator Center (SLAC) is located in northern California, USA. Radiological environmental protection is one of the main elements of the radiation protection program. One of SLAC's accelerator facilities is B-Factory, whose PEP-II accelerator ring has been operating since 1997 and is being upgraded to higher luminosity operation. Four radiological issues associated with high luminosity operation up to CY2008 are re-evaluated: (1) annual doses in IR halls, (2) annual skyshine doses at site boundaries, (3) potential radioactive air releases, and (4) potential groundwater activation. This paper presents the skyshine doses and air emission doses to the Maximally Exposed Individual (MEI) at SLAC site boundaries. The normal beam loss scenarios around PEP-II ring are presented first. In CY2008, the luminosity is 2 x 10{sup 34} cm{sup -2} s{sup -1}, and the stored current is 4.0-A for low-energy ring (LER ) and 2.2-A for high-energy ring (HER). The beam losses around PEP-II ring include those near injection region in IR10 and IR8 and those at collimators (e.g., HER collimators in IR12, LER collimators in IR4 and IR6). The beam losses in IR8 and IR10 (where injection into ring occurs) are further divided into septum, BAD (beam abort dump) and TD (tune-up dump), as well as apertures. The skyshine prompt dose rate distributions as a function of distance from an IR hall at four directions were calculated using the MARS15 Monte Carlo code. For skyshine dose to the MEI, the annual dose (7200 h/y occupancy) is calculated to be 2.9 mrem/y at Sand Hill Road (from e{sup -} losses in IR12 HER collimators) and 1.2 mrem/y at Horse Track Offices near IR6 (from e{sup +} losses in IR8, IR6 and IR4). These are lower than the SLAC skyshine limit of 5 mrem/y for any single facility within SLAC. Radionuclide productions in the air at the PEP-II IR10 were calculated using MARS15. Beam losses of 9-GeV electrons were assumed in three target cases: the copper TD, septum and BAD

  13. High Energy Flares Of FSRQs: The Connection Of Flaring States With The Accretion Disk Luminosity

    NASA Astrophysics Data System (ADS)

    Pacciani, Luigi; Tavecchio, F.; Donnarumma, I.; Stamerra, A.

    2016-10-01

    High-Energy gamma-ray flares (E>10 GeV) of Flat Spectrum Radio Quasars (FSRQ) give us strong constraints on jet-physics, and on the surrounding-mediumWe performed the first study of these flares, examining FERMI-LAT archival-data, and triggering 40 ToO-observations from near-ir to TeV (e.g., for PKS 1441+25), at the occurrence of new flaresWe identified about 270 gamma-ray HE flares, and we already investigated peculiar and short-flares of 3C 454.3, CTA 102 and other 10 HE-flares, showing remarkably hard gamma-ray spectra. We argued that these flares originate at parsec distance from the Supermassive Black-Hole (distant scenario), possibly powered by magnetic-reconnections or turbulence in the flowFor the whole sample of 270 flares, we will show here spectral and temporal propertiesFurthermore, we compared the sub-sample of HE-flares with the whole sample of gamma-ray flares. We will show and discuss that jet luminosities and disks correlate not only on years averaged time-scales, but also during High-Energy gamma-ray flares (time-resolved within this investigation with time-scale of the order of 10 days or less).

  14. Operation of the Cherenkov Detector DIRC of BaBar at High Luminosity

    SciTech Connect

    Spanier, Stefane

    2001-03-07

    The DIRC (acronym for Detection of Internally Reflected Cherenkov (light)) is the ring imaging Cherenkov detector of the BaBar detector at the Pep-II ring of SLAC. It provides the identification of pions, kaons and protons for momenta up to 4 GeV/c with high efficiency. This is needed to reconstruct CP-violating B-decay final states and to provide B-meson flavour tagging for time dependent asymmetry measurements. The DIRC radiators consists of long rectangular bars made of synthetic fused silica and the photon detector is a water tank equipped with an array of 10,752 conventional photomultipliers. At the end of the year 2000 BaBar has recorded about 22 million {bar B}B pairs reaching the design luminosity of L = 3 x 10{sup 33}/cm{sup 2}s. The ability to keep the beam background level low at highest collision rates and the long term reliability of the DIRC components during continuous data taking are requirements of BaBar to accomplish its physics program.

  15. MAD Adaptive Optics Imaging of High-luminosity Quasars: A Pilot Project

    NASA Astrophysics Data System (ADS)

    Liuzzo, E.; Falomo, R.; Paiano, S.; Treves, A.; Uslenghi, M.; Arcidiacono, C.; Baruffolo, A.; Diolaiti, E.; Farinato, J.; Lombini, M.; Moretti, A.; Ragazzoni, R.; Brast, R.; Donaldson, R.; Kolb, J.; Marchetti, E.; Tordo, S.

    2016-08-01

    We present near-IR images of five luminous quasars at z ˜ 2 and one at z ˜ 4 obtained with an experimental adaptive optics (AO) instrument at the European Southern Observatory Very Large Telescope. The observations are part of a program aimed at demonstrating the capabilities of multi-conjugated adaptive optics imaging combined with the use of natural guide stars for high spatial resolution studies on large telescopes. The observations were mostly obtained under poor seeing conditions but in two cases. In spite of these nonoptimal conditions, the resulting images of point sources have cores of FWHM ˜ 0.2 arcsec. We are able to characterize the host galaxy properties for two sources and set stringent upper limits to the galaxy luminosity for the others. We also report on the expected capabilities for investigating the host galaxies of distant quasars with AO systems coupled with future Extremely Large Telescopes. Detailed simulations show that it will be possible to characterize compact (2-3 kpc) quasar host galaxies for quasi-stellar objects at z = 2 with nucleus K-magnitude spanning from 15 to 20 (corresponding to absolute magnitude -31 to -26) and host galaxies that are 4 mag fainter than their nuclei.

  16. Field Tolerances for the Triplet Quadrupoles of the LHC High Luminosity Lattice

    SciTech Connect

    Nosochkov, Yuri; Cai, Y.; Jiao, Y.; Wang, M-H.; Fartoukh, S.; Giovannozzi, M.; Maria, R.de; McIntosh, E.

    2012-06-25

    It has been proposed to implement the so-called Achromatic Telescopic Squeezing (ATS) scheme in the LHC high luminosity (HL) lattice to reduce beta functions at the Interaction Points (IP) up to a factor of 8. As a result, the nominal 4.5 km peak beta functions reached in the Inner Triplets (IT) at collision will be increased by the same factor. This, therefore, justifies the installation of new, larger aperture, superconducting IT quadrupoles. The higher beta functions will enhance the effects of the triplet quadrupole field errors leading to smaller beam dynamic aperture (DA). To maintain the acceptable DA, the effects of the triplet field errors must be re-evaluated, thus specifying new tolerances. Such a study has been performed for the so-called '4444' collision option of the HL-LHC layout version SLHCV3.01, where the IP beta functions are reduced by a factor of 4 in both planes with respect to a pre-squeezed value of 60 cm at two collision points. The dynamic aperture calculations were performed using SixTrack. The impact on the triplet field quality is presented.

  17. Influence of collective effects on the performance of high-luminosity colliders

    NASA Astrophysics Data System (ADS)

    Zisman, Michael S.

    1990-04-01

    The design of a high-luminosity electron-positron collider to study B physics is a challenging task from many points of view. In this paper we consider the influence of collective effects on the machine performance; most of our findings are generic, in the sense that they depend rather weakly on the details of the machine design. Both single-bunch and coupled-bunch instabilities are described and their effects are estimated based upon an example machine design (APIARY-IV). In addition, we examine the possibility of emittance growth from intrabeam scattering and calculate the beam lifetime from both Touschek and gas scattering. We find that the single-bunch instabilities should not lead to difficulty, and that the emittance growth is essentially negligible. At a background gas pressure of 10 nTorr, beam lifetimes of only a few hours are expected. Multibunch growth rates are very severe, even when using an optimized RF system consisting of single-cell, room-temperature RF cavities with geometrical shapes typical of superconducting cavities. Thus, a powerful feedback system will be required. In terms of collective effects, it does not appear.

  18. A new high-gradient correction quadrupole for the Fermilab luminosity upgrade

    SciTech Connect

    Mantsch, P.; Carson, J.; Riddiford, A.; Lamm, M.J.

    1989-03-01

    Special superconducting correction quadrupoles are needed for the luminosity upgrade of the Fermilab Tevatron Collider. These correctors are part of the low-beta system for the interaction regions at B/phi/ and D/phi/. The requirements are high gradient and low current. A quadrupole has been designed that meets the operating gradient of 0.63 T/cm at 1086 A. The one-layer quadrupole is wound with a cable consisting of five individually insulated rectangular strands. The five strands are overwrapped with Kapton and epoxy impregnated glass tape. The winding, curing and collaring of the magnet is accomplished in the same manner as Tevatron-like magnets using Rutherford style cable. Once the magnet is complete the five strands are connected in series. A prototype quadrupole has been assembled and tested. The magnet reached a plateau current of 1560 A corresponding to a gradient of 0.91 T/cm without training. The measured field harmonics are substantially better than required. 8 refs., 6 figs., 4 tabs.

  19. Boosted Higgs bosons from chromomagnetic b 's: b b ¯h at high luminosity

    NASA Astrophysics Data System (ADS)

    Bramante, Joseph; Delgado, Antonio; Lehman, Landon; Martin, Adam

    2016-03-01

    This paper examines detection prospects and constraints on the chromomagnetic dipole operator for the bottom quark. This operator has a flavor, chirality and Lorentz structure that is distinct from other dimension-6 operators considered in Higgs coupling studies. Its nonstandard Lorentz structure results in boosted b b ¯h events, providing a rate-independent signal of new physics. To date, we find this operator is unconstrained by p p →h +jets and p p →b ¯b searches: for order-1 couplings the permitted cutoff Λ for this operator can be as low as Λ ˜1 TeV . We show how to improve this bound with collider cuts that allow a b -tagged Higgs-plus-dijet search in the Higgs-to-diphoton decay channel to exclude cutoffs as high as ˜6 TeV at 2 σ with 3 ab-1 of luminosity at the 14 TeV LHC. Cuts on the pT of the Higgs are key to this search, because the chromomagnetic dipole yields a nonstandard fraction of boosted Higgses.

  20. Development of the Continuous Acquisition Pixel (CAP) sensor for high luminosity lepton colliders

    NASA Astrophysics Data System (ADS)

    Varner, G.; Aihara, H.; Barbero, M.; Bozek, A.; Browder, T.; Hazumi, M.; Kennedy, J.; Martin, E.; Mueller, J.; Olsen, S.; Palka, H.; Rosen, M.; Ruckman, L.; Stanič, S.; Trabelsi, K.; Tsuboyama, T.; Uchida, K.; Yang, Q.; Yarema, R.

    2006-09-01

    A future higher luminosity B-factory detector and concept study detectors for the proposed International Linear Collider require precision vertex reconstruction while coping with high track densities and radiation exposures. Compared with current silicon strip and hybrid pixels, a significant reduction in the overall detector material thickness is needed to achieve the desired vertex resolution. Considerable progress in the development of thin CMOS-based Monolithic Active Pixel Sensors (MAPS) in recent years makes them a viable technology option and feasibility studies are being actively pursued. The most serious concerns are their radiation hardness and their readout speed. To address these, several prototypes denoted as the Continuous Acquisition Pixel (CAP) sensors have been developed and tested. The latest of the CAP sensor prototypes is CAP3, designed in the TSMC 0.25 μm process with a 5-deep Correlated Double Sample (CDS) pair pipeline in each pixel. A setup with several CAP3 sensors is under evaluation to assess the performance of a full-scale pixel readout system running at realistic readout speed. Given the similarity in the occupancy numbers and hit throughput requirements, per unit area, between a Belle vertex detector upgradation and the requirements for a future ILC pixel detector, this effort can be considered a small-scale functioning prototype for such a future system. The results and plans for the next stages of R&D towards a full Belle Pixel Vertex Detector (PVD) are presented.

  1. Influence of collective effects on the performance of high-luminosity colliders

    SciTech Connect

    Zisman, M.S.

    1990-04-01

    The design of a high-luminosity electron-positron collider to study B physics is a challenging task from many points of view. In this paper we consider the influence of collective effects on the machine performance; most of our findings are generic,'' in the sense that they depend rather weakly on the details of the machine design. Both single-bunch and coupled-bunch instabilities are described and their effects are estimated based upon an example machine design (APIARY-IV). In addition, we examine the possibility of emittance growth from intrabeam scattering and calculate the beam lifetime from both Touschek and gas scattering. We find that the single-bunch instabilities should not lead to difficulty, and that the emittance growth is essentially negligible. At a background gas pressure of 10 nTorr, beam lifetimes of only a few hours are expected. Multibunch growth rates are very severe, even when using an optimized RF system consisting of single-cell, room-temperature RF cavities with geometrical shapes typical of superconducting cavities. Thus, a powerful feedback system will be required. In terms of collective effects, it does not appear

  2. The global 21-cm signal in the context of the high- z galaxy luminosity function

    NASA Astrophysics Data System (ADS)

    Mirocha, Jordan; Furlanetto, Steven R.; Sun, Guochao

    2017-01-01

    We build a new model for the global 21-cm signal that is calibrated to measurements of the high-z galaxy luminosity function (LF) and further tuned to match the Thomson scattering optical depth of the cosmic microwave background, τe. Assuming that the z ≲ 8 galaxy population can be smoothly extrapolated to higher redshifts, the recent decline in best-fitting values of τe and the inefficient heating induced by X-ray binaries (the presumptive sources of the high-z X-ray background) imply that the entirety of cosmic reionization and reheating occurs at z ≲ 12. In contrast to past global 21-cm models, whose z ˜ 20 (ν ˜ 70 MHz) absorption features and strong ˜25 mK emission features were driven largely by the assumption of efficient early star formation and X-ray heating, our new models peak in absorption at ν ˜ 110 MHz at depths ˜-160 mK and have negligible emission components. Current uncertainties in the faint-end of the LF, binary populations in star-forming galaxies, and UV and X-ray escape fractions introduce ˜20 MHz (˜50 mK) deviations in the trough's frequency (amplitude), while emission signals remain weak (≲10 mK) and are confined to ν ≳ 140 MHz. These predictions, which are intentionally conservative, suggest that the detection of a 21-cm absorption minimum at frequencies below ˜90 MHz and/or emission signals stronger than ˜10mK at ν ≲ 140 MHz would provide strong evidence for `new' sources at high redshifts, such as Population III stars and their remnants.

  3. A Compton-thick Wind in the High Luminosity Quasar, PDS 456

    NASA Technical Reports Server (NTRS)

    Reeves, J. N.; O'Brien, P. T.; Behar, E.; Miller, L.; Turner, T. J.; Braito, V.; Fabian, A. C.; Kaspi, S.; Mushotzky, R.; Ward, M.

    2009-01-01

    PDS 456 is a nearby (z=0.184), luminous (L(sub bol) approximately equal to 10(exp 47) ergs(exp -1) type I quasar. A deep 190 ks Suzaku observation in February 2007 revealed the complex, broad band X-ray spectrum of PDS 456. The Suzaku spectrum exhibits highly statistically significant absorption features near 9 keV in the quasar rest-frame. We show that the most plausible origin of the absorption is from blue-shifted resonance (1s-2p) transitions of hydrogen-like iron (at 6.97 keV in the rest frame). This indicates that a highly ionized outflow may be present moving at near relativistic velocities (0.26-0.31c). A possible hard X-ray excess is detected above 15 keV with HXD (at 99.8% confidence), which may arise from high column density gas (N(sub H) greater than 10(exp 24)cm(exp -2) partially covering the X-ray emission, or through strong Compton reflection. Here we propose that the iron K-shell absorption in PDS 456 is associated with a thick, possibly clumpy outflow, covering about 20% of 4(pi) steradian solid angle. The outflow is likely launched from the inner accretion disk, within 15-100 gravitational radii of the black hole. The kinetic power of the outflow may be similar to the bolometric luminosity of PDS 456. Such a powerful wind could have a significant effect on the co-evolution of the host galaxy and its supermassive black hole, through feedback.

  4. Routine preoperative insertion of IABP in high-risk off-pump coronary artery bypass grafting.

    PubMed

    Vohra, Hunaid A; Briffa, Norman P

    2005-01-01

    The beneficial effects of intraaortic balloon pump (IABP) in coronary artery bypass graft surgery with cardiopulmonary bypass have been reported. However, whether preoperative insertion of IABP in high-risk off-pump coronary artery bypass grafting (OPCAB) has any beneficial effects remains to be established. We report our experience of preoperative insertion of IABP in OPCAB.

  5. Fundamental cavity impedance and longitudinal coupled-bunch instabilities at the High Luminosity Large Hadron Collider

    NASA Astrophysics Data System (ADS)

    Baudrenghien, P.; Mastoridis, T.

    2017-01-01

    The interaction between beam dynamics and the radio frequency (rf) station in circular colliders is complex and can lead to longitudinal coupled-bunch instabilities at high beam currents. The excitation of the cavity higher order modes is traditionally damped using passive devices. But the wakefield developed at the cavity fundamental frequency falls in the frequency range of the rf power system and can, in theory, be compensated by modulating the generator drive. Such a regulation is the responsibility of the low-level rf (llrf) system that measures the cavity field (or beam current) and generates the rf power drive. The Large Hadron Collider (LHC) rf was designed for the nominal LHC parameter of 0.55 A DC beam current. At 7 TeV the synchrotron radiation damping time is 13 hours. Damping of the instability growth rates due to the cavity fundamental (400.789 MHz) can only come from the synchrotron tune spread (Landau damping) and will be very small (time constant in the order of 0.1 s). In this work, the ability of the present llrf compensation to prevent coupled-bunch instabilities with the planned high luminosity LHC (HiLumi LHC) doubling of the beam current to 1.1 A DC is investigated. The paper conclusions are based on the measured performances of the present llrf system. Models of the rf and llrf systems were developed at the LHC start-up. Following comparisons with measurements, the system was parametrized using these models. The parametric model then provides a more realistic estimation of the instability growth rates than an ideal model of the rf blocks. With this modeling approach, the key rf settings can be varied around their set value allowing for a sensitivity analysis (growth rate sensitivity to rf and llrf parameters). Finally, preliminary measurements from the LHC at 0.44 A DC are presented to support the conclusions of this work.

  6. Concepts for ELIC - A High Luminosity CEBAF Based Electron-Light Ion Collider

    SciTech Connect

    Ya. Derbenev, A. Bogacz, G. Krafft, R. Li, L. Merminga, B. Yunn, Y. Zhang

    2006-09-01

    A CEBAF accelerator based electron-light ion collider (ELIC) of rest mass energy from 20 to 65 GeV and luminosity from 10^33 to 10^35 cm6-2s^-1 with both beams polarized is envisioned as a future upgrade to CEBAF. A two step upgrade scenario is under study: CEBAF accelerator-ring-ring scheme (CRR) as the first step, and a multi-turn ERL-ring as the second step, to attain a better electron emittance and maximum luminosity. In this paper we report results of our studies of the CRR version of ELIC.

  7. The hard X-ray luminosity function of high-redshift (3 < z ≲ 5) active galactic nuclei

    NASA Astrophysics Data System (ADS)

    Vito, F.; Gilli, R.; Vignali, C.; Comastri, A.; Brusa, M.; Cappelluti, N.; Iwasawa, K.

    2014-12-01

    We present the hard-band (2-10 keV) X-ray luminosity function (HXLF) of 0.5-2 keV band selected active galactic nuclei (AGN) at high redshift. We have assembled a sample of 141 AGN at 3 < z ≲ 5 from X-ray surveys of different size and depth, in order to sample different regions in the LX - z plane. The HXLF is fitted in the range log LX ˜ 43-45 with standard analytical evolutionary models through a maximum likelihood procedure. The evolution of the HXLF is well described by a pure density evolution, with the AGN space density declining by a factor of ˜10 from z = 3 to 5. A luminosity-dependent density evolution model, which, normally, best represents the HXLF evolution at lower redshift, is also consistent with the data, but a larger sample of low-luminosity (log LX < 44), high-redshift AGN is necessary to constrain this model. We also estimated the intrinsic fraction of AGN obscured by a column density log NH ≥ 23 to be 0.54 ± 0.05, with no strong dependence on luminosity. This fraction is higher than the value in the Local Universe, suggesting an evolution of the luminous (LX > 1044 erg s-1) obscured AGN fraction from z = 0 to z > 3.

  8. Large area thinned planar sensors for future high-luminosity-LHC upgrades

    NASA Astrophysics Data System (ADS)

    Wittig, T.; Lawerenz, A.; Röder, R.

    2016-12-01

    Planar hybrid silicon sensors are a well proven technology for past and current particle tracking detectors in HEP experiments. However, the future high-luminosity upgrades of the inner trackers at the LHC experiments pose big challenges to the detectors. A first challenge is an expected radiation damage level of up to 2ṡ 1016 neq/cm2. For planar sensors, one way to counteract the charge loss and thus increase the radiation hardness is to decrease the thickness of their active area. A second challenge is the large detector area which has to be built as cost-efficient as possible. The CiS research institute has accomplished a proof-of-principle run with n-in-p ATLAS-Pixel sensors in which a cavity is etched to the sensor's back side to reduce its thickness. One advantage of this technology is the fact that thick frames remain at the sensor edges and guarantee mechanical stability on wafer level while the sensor is left on the resulting thin membrane. For this cavity etching technique, no handling wafers are required which represents a benefit in terms of process effort and cost savings. The membranes with areas of up to ~ 4 × 4 cm2 and thicknesses of 100 and 150 μm feature a sufficiently good homogeneity across the whole wafer area. The processed pixel sensors show good electrical behaviour with an excellent yield for a suchlike prototype run. First sensors with electroless Ni- and Pt-UBM are already successfully assembled with read-out chips.

  9. High Frequency Cluster Radio Galaxies: Luminosity Functions and Implications for SZE Selected Cluster Samples

    NASA Astrophysics Data System (ADS)

    Gupta, N.; Saro, A.; Mohr, J. J.; Benson, B. A.; Bocquet, S.; Capasso, R.; Carlstrom, J. E.; Chiu, I.; Crawford, T. M.; de Haan, T.; Dietrich, J. P.; Gangkofner, C.; Holzapfel, W. L.; McDonald, M.; Rapetti, D.; Reichardt, C. L.

    2017-01-01

    We study the overdensity of point sources in the direction of X-ray-selected galaxy clusters from the Meta-Catalog of X-ray detected Clusters of galaxies (MCXC; = 0.14) at South Pole Telescope (SPT) and Sydney University Molonglo Sky Survey (SUMSS) frequencies. Flux densities at 95, 150 and 220 GHz are extracted from the 2500 deg2 SPT-SZ survey maps at the locations of SUMSS sources, producing a multi-frequency catalog of radio galaxies. In the direction of massive galaxy clusters, the radio galaxy flux densities at 95 and 150 GHz are biased low by the cluster Sunyaev-Zel'dovich Effect (SZE) signal, which is negative at these frequencies. We employ a cluster SZE model to remove the expected flux bias and then study these corrected source catalogs. We find that the high frequency radio galaxies are centrally concentrated within the clusters and that their luminosity functions (LFs) exhibit amplitudes that are characteristically an order of magnitude lower than the cluster LF at 843 MHz. We use the 150 GHz LF to estimate the impact of cluster radio galaxies on an SPT-SZ like survey. The radio galaxy flux typically produces a small bias on the SZE signal and has negligible impact on the observed scatter in the SZE mass-observable relation. If we assume there is no redshift evolution in the radio galaxy LF then 1.8 ± 0.7 percent of the clusters with detection significance ξ ≥ 4.5 would be lost from the sample. Allowing for redshift evolution of the form (1 + z)2.5 increases the incompleteness to 5.6 ± 1.0 percent. Improved constraints on the evolution of the cluster radio galaxy LF require a larger cluster sample extending to higher redshift.

  10. Light dark sector searches at low-energy high-luminosity e + e - colliders

    NASA Astrophysics Data System (ADS)

    Yin, Peng-Fei; Zhu, Shou-Hua

    2016-10-01

    Although the standard model (SM) is extremely successful, there are various motivations for considering the physics beyond the SM. For example, the SM includes neither dark energy nor dark matter, which has been confirmed through astrophysical observations. Examination of the dark sector, which contains new, light, weakly-coupled particles at the GeV scale or lower, is well motivated by both theory and dark-matter detection experiments. In this mini-review, we focus on one particular case in which these new particles can interact with SM particles through a kinematic mixing term between U(1) gauge bosons. The magnitude of the mixing can be parameterized by a parameter є. Following a brief overview of the relevant motivations and the constraints determined from numerous experiments, we focus on the light dark sector phenomenology at low-energy high-luminosity e + e - colliders. These colliders are ideal for probing the new light particles, because of their large production rates and capacity for precise resonance reconstruction. Depending on the details of a given model, the typical observed signatures may also contain multi lepton pairs, displaced vertices, and/or missing energy. Through the use of extremely large data samples from existing experiments, such as KLOE, CLEO, BABAR, Belle, and BESIII, the magnitude of the mixing can be parameterized by a parameter є < 10-4-10-3 constraint can be obtained. Obviously, future experiments with larger datasets will provide opportunities for the discovery of new particles in the dark sector, or for stricter upper limits on є. Once the light dark sector is confirmed, the particle physics landscape will be changed significantly.

  11. Conductor Specification and Validation for High-Luminosity LHC Quadrupole Magnets

    DOE PAGES

    Cooley, L. D.; Ghosh, A. K.; Dietderich, D. R.; ...

    2017-06-01

    The High Luminosity Upgrade of the Large Hadron Collider (HL-LHC) at CERN will replace the main ring inner triplet quadrupoles, identified by the acronym MQXF, adjacent to the main ring intersection regions. For the past decade, the U.S. LHC Accelerator R&D Program, LARP, has been evaluating conductors for the MQXFA prototypes, which are the outer magnets of the triplet. Recently, the requirements for MQXF magnets and cables have been published in P. Ferracin et al., IEEE Trans. Appl. Supercond., vol. 26, no. 4, 2016, Art. no.4000207, along with the final specification for Ti-alloyed Nb3Sn conductor determined jointly by CERN andmore » LARP. This paper describes the rationale beneath the 0.85 mm diameter strand’s chief parameters, which are 108 or more sub-elements, a copper fraction not less than 52.4%, strand critical current at 4.22 K not less than 631 A at 12 T and 331 A at 15 T, and residual resistance ratio of not less than 150. This paper also compares the performance for ~100 km production lots of the five most recent LARP conductors to the first 163 km of strand made according to the HL-LHC specification. Two factors emerge as significant for optimizing performance and minimizing risk: a modest increase of the sub-element diameter from 50 to 55 μm, and a Nb:Sn molar ratio of 3.6 instead of 3.4. Furthermore, the statistics acquired so far give confidence that the present conductor can balance competing demands in production for the HL-LHC project.« less

  12. An empirical model for the galaxy luminosity and star formation rate function at high redshift

    NASA Astrophysics Data System (ADS)

    Mashian, Natalie; Oesch, Pascal A.; Loeb, Abraham

    2016-01-01

    Using the most recent measurements of the ultraviolet (UV) luminosity functions (LFs) and dust estimates of early galaxies, we derive updated dust-corrected star formation rate functions (SFRFs) at z ˜ 4-8, which we model to predict the evolution to higher redshifts, z > 8. We employ abundance matching techniques to calibrate a relation between galaxy star formation rate (SFR) and host halo mass Mh by mapping the shape of the observed SFRFs at z ˜ 4-8 to that of the halo mass function. The resulting scaling law remains roughly constant over this redshift range. We apply the average SFR-Mh relation to reproduce the observed SFR functions at 4 ≲ z ≲ 8 and also derive the expected UV LFs at higher redshifts. At z ˜ 9 and z ˜ 10 these model LFs are in excellent agreement with current observed estimates. Our predicted number densities and UV LFs at z > 10 indicate that James Webb Space Telescope will be able to detect galaxies out to z ˜ 15 with an extensive treasury sized program. We also derive the redshift evolution of the star formation rate density (SFRD) and associated reionization history by galaxies. Models which integrate down to the current HUDF12/XDF detection limit (MUV ˜ -17.7 mag) result in a SFRD that declines as (1 + z)-10.4 ± 0.3 at high redshift and fail to reproduce the observed cosmic microwave background electron scattering optical depth, τ ≃ 0.066, to within 1σ. On the other hand, we find that the inclusion of galaxies with SFRs well below the current detection limit (MUV < -5.7 mag) leads to a fully reionized universe by z ˜ 6.5 and an optical depth of τ ≃ 0.054, consistent with the recently derived Planck value at the 1σ level.

  13. High-frequency cluster radio galaxies: luminosity functions and implications for SZE-selected cluster samples

    NASA Astrophysics Data System (ADS)

    Gupta, N.; Saro, A.; Mohr, J. J.; Benson, B. A.; Bocquet, S.; Capasso, R.; Carlstrom, J. E.; Chiu, I.; Crawford, T. M.; de Haan, T.; Dietrich, J. P.; Gangkofner, C.; Holzapfel, W. L.; McDonald, M.; Rapetti, D.; Reichardt, C. L.

    2017-05-01

    We study the overdensity of point sources in the direction of X-ray-selected galaxy clusters from the meta-catalogue of X-ray-detected clusters of galaxies (MCXC; = 0.14) at South Pole Telescope (SPT) and Sydney University Molonglo Sky Survey (SUMSS) frequencies. Flux densities at 95, 150 and 220 GHz are extracted from the 2500 deg2 SPT-SZ survey maps at the locations of SUMSS sources, producing a multifrequency catalogue of radio galaxies. In the direction of massive galaxy clusters, the radio galaxy flux densities at 95 and 150 GHz are biased low by the cluster Sunyaev-Zel'dovich Effect (SZE) signal, which is negative at these frequencies. We employ a cluster SZE model to remove the expected flux bias and then study these corrected source catalogues. We find that the high-frequency radio galaxies are centrally concentrated within the clusters and that their luminosity functions (LFs) exhibit amplitudes that are characteristically an order of magnitude lower than the cluster LF at 843 MHz. We use the 150 GHz LF to estimate the impact of cluster radio galaxies on an SPT-SZ like survey. The radio galaxy flux typically produces a small bias on the SZE signal and has negligible impact on the observed scatter in the SZE mass-observable relation. If we assume there is no redshift evolution in the radio galaxy LF then 1.8 ± 0.7 per cent of the clusters with detection significance ξ ≥ 4.5 would be lost from the sample. Allowing for redshift evolution of the form (1 + z)2.5 increases the incompleteness to 5.6 ± 1.0 per cent. Improved constraints on the evolution of the cluster radio galaxy LF require a larger cluster sample extending to higher redshift.

  14. A physical model for the evolving ultraviolet luminosity function of high redshift galaxies and their contribution to the cosmic reionization

    SciTech Connect

    Cai, Zhen-Yi; Lapi, Andrea; Bressan, Alessandro; De Zotti, Gianfranco; Danese, Luigi; Negrello, Mattia

    2014-04-10

    We present a physical model for the evolution of the ultraviolet (UV) luminosity function of high-redshift galaxies, taking into account in a self-consistent way their chemical evolution and the associated evolution of dust extinction. Dust extinction is found to increase fast with halo mass. A strong correlation between dust attenuation and halo/stellar mass for UV selected high-z galaxies is thus predicted. The model yields good fits of the UV and Lyman-α (Lyα) line luminosity functions at all redshifts at which they have been measured. The weak observed evolution of both luminosity functions between z = 2 and z = 6 is explained as the combined effect of the negative evolution of the halo mass function; of the increase with redshift of the star formation efficiency due to the faster gas cooling; and of dust extinction, differential with halo mass. The slope of the faint end of the UV luminosity function is found to steepen with increasing redshift, implying that low luminosity galaxies increasingly dominate the contribution to the UV background at higher and higher redshifts. The observed range of the UV luminosities at high z implies a minimum halo mass capable of hosting active star formation M {sub crit} ≲ 10{sup 9.8} M {sub ☉}, which is consistent with the constraints from hydrodynamical simulations. From fits of Lyα line luminosity functions, plus data on the luminosity dependence of extinction, and from the measured ratios of non-ionizing UV to Lyman-continuum flux density for samples of z ≅ 3 Lyman break galaxies and Lyα emitters, we derive a simple relationship between the escape fraction of ionizing photons and the star formation rate. It implies that the escape fraction is larger for low-mass galaxies, which are almost dust-free and have lower gas column densities. Galaxies already represented in the UV luminosity function (M {sub UV} ≲ –18) can keep the universe fully ionized up to z ≅ 6. This is consistent with (uncertain) data

  15. Run II luminosity progress

    SciTech Connect

    Gollwitzer, K.; /Fermilab

    2007-06-01

    The Fermilab Tevatron Collider Run II program continues at the energy and luminosity frontier of high energy particle physics. To the collider experiments CDF and D0, over 3 fb{sup -1} of integrated luminosity has been delivered to each. Upgrades and improvements in the Antiproton Source of the production and collection of antiprotons have led to increased number of particles stored in the Recycler. Electron cooling and associated improvements have help make a brighter antiproton beam at collisions. Tevatron improvements to handle the increased number of particles and the beam lifetimes have resulted in an increase in luminosity.

  16. THE CANADA-FRANCE HIGH-z QUASAR SURVEY: NINE NEW QUASARS AND THE LUMINOSITY FUNCTION AT REDSHIFT 6

    SciTech Connect

    Willott, Chris J.; Crampton, David; Hutchings, John B.; Schade, David; Delorme, Philippe; Reyle, Celine; Albert, Loic; Bergeron, Jacqueline; Omont, Alain; Delfosse, Xavier; Forveille, Thierry; McLure, Ross J.

    2010-03-15

    We present discovery imaging and spectroscopy for nine new z {approx} 6 quasars found in the Canada-France High-z Quasar Survey (CFHQS) bringing the total number of CFHQS quasars to 19. By combining the CFHQS with the more luminous Sloan Digital Sky Survey sample, we are able to derive the quasar luminosity function from a sample of 40 quasars at redshifts 5.74 < z < 6.42. Our binned luminosity function shows a slightly lower normalization and flatter slope than found in previous work. The binned data also suggest a break in the luminosity function at M {sub 1450} {approx} -25. A double power-law maximum likelihood fit to the data is consistent with the binned results. The luminosity function is strongly constrained (1{sigma} uncertainty <0.1 dex) over the range -27.5 < M {sub 1450} < -24.7. The best-fit parameters are {phi}(M*{sub 1450}) = 1.14 x 10{sup -8} Mpc{sup -3} mag{sup -1}, break magnitude M*{sub 1450} = -25.13, and bright end slope {beta} = -2.81. However, the covariance between {beta} and M*{sub 1450} prevents strong constraints being placed on either parameter. For a break magnitude in the range -26 < M*{sub 1450} < -24, we find -3.8 < {beta} < -2.3 at 95% confidence. We calculate the z = 6 quasar intergalactic ionizing flux and show it is between 20 and 100 times lower than that necessary for reionization. Finally, we use the luminosity function to predict how many higher redshift quasars may be discovered in future near-IR imaging surveys.

  17. Final Cooling for a High-Energy High-Luminosity Lepton Collider

    SciTech Connect

    Neuffer, David; Sayed, H.; Hart, T.; Summers, D.

    2015-12-03

    A high-energy muon collider scenario require a “final cooling” system that reduces transverse emittance by a factor of ~10 while allowing longitudinal emittance increase. The baseline approach has low-energy transverse cooling within high-field solenoids, with strong longitudinal heating. This approach and its recent simulation are discussed. Alternative approaches which more explicitly include emittance exchange are also presented. Round-to-flat beam transform, transverse slicing, and longitudinal bunch coalescence are possible components of an alternative approach. Wedge-based emittance exchange could provide much of the required transverse cooling with longitudinal heating. Li-lens and quadrupole focusing systems could also provide much of the required final cooling.

  18. Final cooling for a high-energy high-luminosity lepton collider

    NASA Astrophysics Data System (ADS)

    Neuffer, D.; Sayed, H.; Acosta, J.; Hart, T.; Summers, D.

    2017-07-01

    A high-energy muon collider requires a "final cooling" system that reduces transverse emittance by a factor of ~ 10, while allowing the longitudinal emittance to increase. The baseline approach has low-energy transverse cooling within high-field solenoids, with strong longitudinal heating. This approach and its recent simulation are discussed. Alternative approaches, which more explicitly include emittance exchange are also presented. Round-to-flat beam transform, transverse slicing, and longitudinal bunch coalescence are possible components of an alternative approach. Wedge-based emittance exchange could provide much of the required transverse cooling with longitudinal heating. Li-lens and quadrupole focusing systems could also provide much of the required final cooling.

  19. Prospects for BSM searches at the high-luminosity LHC with the CMS detector

    NASA Astrophysics Data System (ADS)

    Shchutska, Lesya; CMS Collaboration

    2016-04-01

    After a series of upgrades the Large Hadron Collider will deliver an integrated luminosity of up to 3000 fb-1 with √{ s} = 14 GeV for each experiment. Aspects of the supersymmetry and other beyond the standard model (BSM) search programme are discussed for this scenario. These include the expected discovery reach for gluinos decaying to third generation squarks as well as to light squarks, for the third generation squark decaying to top quarks and neutralino and for the neutralino-chargino pairs decaying to final states including a Z and a W boson. Depending on the SUSY particles, the discovery reach can be improved by about 300 to 400 GeV with increasing the luminosity from 300 to 3000 fb-1. The potential for discovery of non-SUSY new particles is also discussed.

  20. High luminosity operation, beam-beam effects and their compensation in Tevatron

    SciTech Connect

    Shiltsev, V.; /Fermilab

    2008-06-01

    Over the past 2 years the Tevatron peak luminosity steadily progressed and reached the level of 3.15 {center_dot} 10{sup 32} cm{sup -2} s{sup -1} which exceeds the Run II Upgrade goal. We discuss the collider performance, illustrate limitations and understanding of beam-beam effects and present experimental results of compensation of the beam-beam effects by electron lenses--a technique of great interest for the LHC.

  1. Cryogenic test of double quarter wave crab cavity for the LHC High luminosity upgrade

    SciTech Connect

    Xiao, B.; Alberty, L.; Belomestnykh, S.; Ben-Zvi, I.; Calaga, R.; Cullen, C.; Capatina, O.; Hammons, L.; Li, Z.; Marques, C.; Skaritka, J.; Verdu-Andres, S.; Wu, Q.

    2015-05-03

    A Proof-of-Principle (PoP) Double Quarter Wave Crab Cavity (DQWCC) was designed and fabricated for the Large Hadron Collider (LHC) luminosity upgrade. A vertical cryogenic test has been done at Brookhaven National Lab (BNL). The cavity achieved 4.5 MV deflecting voltage with a quality factor above 3×109. We report the test results of this design.

  2. Recent Progress on Design Studies of High-Luminosity Ring-Ring Electron-Ion Collider at CEBAF

    SciTech Connect

    Zhang, Y; Bruell, A; Chevtsov, P; Derbenev, Y S; Ent, R; Krafft, G A; Li, R; Merminga, L; Yunn, B C

    2009-05-01

    The conceptual design of a ring-ring electron-ion collider based on CEBAF has been continuously optimized to cover a wide center-of-mass energy region and to achieve high luminosity and polarization to support next generation nuclear science programs. Here, we summarize the recent design improvements and R&D progress on interaction region optics with chromatic aberration compensation, matching and tracking of electron polarization in the Figure-8 ring, beam-beam simulations and ion beam cooling studies.

  3. PROBING HIGH-REDSHIFT GALAXY FORMATION AT THE HIGHEST LUMINOSITIES: NEW INSIGHTS FROM DEIMOS SPECTROSCOPY

    SciTech Connect

    Lee, Kyoung-Soo; Dey, Arjun; Cooper, Michael C.; Reddy, Naveen; Jannuzi, Buell T.

    2013-07-01

    We present Keck DEIMOS spectroscopic observations of the most UV-luminous star-forming galaxies at redshifts 3.2 < z < 4.6. Our sample, selected in the Booetes field of the NOAO Deep Wide-Field Survey, contains galaxies with luminosities of L* {approx}< L{sub UV} {approx}< 7 L* and is one of the largest samples to date of the most UV-luminous galaxies at these redshifts. Our spectroscopic data confirm 41 candidates as star-forming galaxies at 3.2 < z < 4.6 and validate the relatively clean selection of the photometric candidates with a contamination rate of 11%-28%. We find that the fraction of Ly{alpha} emitting galaxies increases with decreasing UV luminosity. None of the 12 galaxies with M{sub UV} < -22 (i.e., L{sub UV} > 3 L*) exhibit strong Ly{alpha} emission. We find strong evidence of large-scale outflows, transporting the neutral/ionized gas in the interstellar medium away from the galaxy. Galaxies exhibiting both interstellar absorption and Ly{alpha} emission lines show a significant offset between the two features, with a relative velocity of 200-1150 km s{sup -1}. We find tentative evidence that this measure of the outflow velocity increases with UV luminosity and/or stellar mass. The luminosity- and mass-dependent outflow strengths suggest that the efficiency of feedback and enrichment of the surrounding medium depend on these galaxy parameters. We also stack the individual spectra to construct composite spectra of the absorption-line-only and Ly{alpha}-emitting subsets of the UV luminous galaxies at z {approx_equal} 3.7. The composite spectra are very similar to those of lower-redshift and lower-luminosity Lyman break galaxy (LBG) samples, but with some subtle differences. Analyses of the composite spectra suggest that the UV luminous LBGs at z {approx_equal} 3.7 may have a higher covering fraction of absorbing gas, and may be older (or have had more prolonged star formation histories) than their lower-redshift and lower-luminosity counterparts. In

  4. Discovery of 1-5 Hz flaring at high luminosity in SAX J1808.4-3658

    SciTech Connect

    Bult, Peter; Van der Klis, Michiel

    2014-07-10

    We report the discovery of a 1-5 Hz X-ray flaring phenomenon observed at >30 mCrab near peak luminosity in the 2008 and 2011 outbursts of the accreting millisecond X-ray pulsar SAX J1808.4-3658 in observations with the Rossi X-ray Timing Explorer. In each of the two outbursts this high luminosity flaring is seen for ∼3 continuous days and switches on and off on a timescale of 1-2 hr. The flaring can be seen directly in the light curve, where it shows sharp spikes of emission at quasi-regular separation. In the power spectrum it produces a broad noise component, which peaks at 1-5 Hz. The total 0.05-10 Hz variability has a fractional rms amplitude of 20%-45%, well in excess of the 8%-12% rms broadband noise usually seen in power spectra of SAX J1808.4-3658. We perform a detailed timing analysis of the flaring and study its relation to the 401 Hz pulsations. We find that the pulse amplitude varies proportionally with source flux through all phases of the flaring, indicating that the flaring is likely due to mass density variations created at or outside the magnetospheric boundary. We suggest that this 1-5 Hz flaring is a high mass accretion rate version of the 0.5-2 Hz flaring which is known to occur at low luminosity (<13 mCrab), late in the tail of outbursts of SAX J1808.4-3658. We propose the dead-disk instability, previously suggested as the mechanism for the 0.5-2 Hz flaring, as a likely mechanism for the high luminosity flaring reported here.

  5. Subaru High-z Exploration of Low-Luminosity Quasars (SHELLQs): New z > 6 Quasar Survey with Subaru/HSC

    NASA Astrophysics Data System (ADS)

    Matsuoka, Yoshiki; SHELLQs Collaboration

    2017-01-01

    Quasars at high redshift are an important and unique probe of the distant Universe, for understanding the origin and progress of cosmic reionization, the early growth of supermassive black holes, and the evolution of quasar host galaxies and their dark matter halos, among other topics. We are currently carrying out a new spectroscopic survey, called SHELLQs (Subaru High-z Exploration of Low-Luminosity Quasars), to search for low-luminosity quasars at z > 6. By exploiting the exquisite imaging data produced by the Subaru Hyper Suprime-Cam (HSC) survey, we aim to probe quasar luminosities down to M1450 ~ -22 mag, i.e., below the classical threshold between quasars and Seyfert galaxies. Candidate selection is performed by combining several photometric approaches including a Bayesian probabilistic algorithm. A large spectroscopic observing program is underway, using Subaru/FOCAS, GTC/OSIRIS, and Gemini/GMOS; in particular, SHELLQs has been approved as a Subaru intensive program to use 20 nights in the coming four semesters. As of August 2016, we have discovered ~40 quasars and bright galaxies at z ~ 6 and beyond, from the first 100 deg2 of the HSC survey (Matsuoka et al. 2016, ApJ, 828, 26). Surprisingly, we are starting to see the steep rise of the luminosity function of high-z galaxies, compared with that of quasars, at magnitudes fainter than M1450 ~ -22 mag or zAB ~ 24 mag. Multi-wavelength follow-up studies of the discovered objects as well as further survey observations are ongoing.

  6. Performance of the first short model 150 mm aperture Nb$_3$Sn Quadrupole MQXFS for the High- Luminosity LHC upgrade

    SciTech Connect

    Chlachidze, G.; et al.

    2016-08-30

    The US LHC Accelerator Research Program (LARP) and CERN combined their efforts in developing Nb3Sn magnets for the High-Luminosity LHC upgrade. The ultimate goal of this collaboration is to fabricate large aperture Nb3Sn quadrupoles for the LHC interaction regions (IR). These magnets will replace the present 70 mm aperture NbTi quadrupole triplets for expected increase of the LHC peak luminosity by a factor of 5. Over the past decade LARP successfully fabricated and tested short and long models of 90 mm and 120 mm aperture Nb3Sn quadrupoles. Recently the first short model of 150 mm diameter quadrupole MQXFS was built with coils fabricated both by the LARP and CERN. The magnet performance was tested at Fermilab’s vertical magnet test facility. This paper reports the test results, including the quench training at 1.9 K, ramp rate and temperature dependence studies.

  7. Support Structure Design of the $$\\hbox{Nb}_{3}\\hbox{Sn}$$ Quadrupole for the High Luminosity LHC

    DOE PAGES

    Juchno, M.; Ambrosio, G.; Anerella, M.; ...

    2014-10-31

    New low-β quadrupole magnets are being developed within the scope of the High Luminosity LHC (HL-LHC) project in collaboration with the US LARP program. The aim of the HLLHC project is to study and implement machine upgrades necessary for increasing the luminosity of the LHC. The new quadrupoles, which are based on the Nb₃Sn superconducting technology, will be installed in the LHC Interaction Regions and will have to generate a gradient of 140 T/m in a coil aperture of 150 mm. In this paper, we describe the design of the short model magnet support structure and discuss results of themore » detailed 3D numerical analysis performed in preparation for the first short model test.« less

  8. Exploratory study of a novel low occupancy vertex detector architecture based on high precision timing for high luminosity particle colliders

    NASA Astrophysics Data System (ADS)

    Orel, Peter; Varner, Gary S.; Niknejadi, Pardis

    2017-06-01

    Vertex detectors provide space-time coordinates for the traversing charged particle decay products closest to the interaction point. Resolving these increasingly intense particle fluences at high luminosity particle colliders, such as SuperKEKB, is an ever growing challenge. This results in a non-negligible occupancy of the vertex detector using existing low material budget techniques. Consequently, new approaches are being studied that meet the vertexing requirements while lowering the occupancy. In this paper, we introduce a novel vertex detector architecture. Its design relies on an asynchronous digital pixel matrix in combination with a readout based on high precision time-of-flight measurement. Denoted the Timing Vertex Detector (TVD), it consists of a binary pixel array, a transmission line for signal collection, and a readout ASIC. The TVD aims to have a spatial resolution comparable to the existing Belle2 vertex detector. At the same time it offers a reduced occupancy by a factor of ten while decreasing the channel count by almost three orders of magnitude. Consequently, reducing the event size from about 1 MB/event to about 5.9 kB/event.

  9. SuperB: A High-Luminosity Asymmetric e+e- Super Flavor Factory

    SciTech Connect

    Bona, M.; /et al.

    2007-05-18

    We discuss herein the exciting physics program that can be accomplished with a very large sample of heavy quark and heavy lepton decays produced in the very clean environment of an e{sup +}e{sup -} collider; a program complementary to that of an experiment such as LHCb at a hadronic machine. It then presents the conceptual design of a new type of e{sup +}e{sup -} collider that produces a nearly two-order-of-magnitude increase in luminosity over the current generation of asymmetric B Factories. The key idea is the use of low emittance beams produced in an accelerator lattice derived from the ILC Damping Ring Design, together with a new collision region, again with roots in the ILC final focus design, but with important new concepts developed in this design effort. Remarkably, SuperB produces this very large improvement in luminosity with circulating currents and wallplug power similar to those of the current B Factories. There is clear synergy with ILC R&D; design efforts have already influenced one another, and many aspects of the ILC Damping Rings and Final Focus would be operationally tested at SuperB. Finally, the design of an appropriate detector, based on an upgrade of BABAR as an example, is discussed in some detail. A preliminary cost estimate is presented, as is an example construction timeline.

  10. Magnetic Measurements of the First Nb3Sn Model Quadrupole (MQXFS) for the High-Luminosity LHC

    DOE PAGES

    DiMarco, J.; Ambrosio, G.; Chlachidze, G.; ...

    2016-12-12

    The US LHC Accelerator Research Program (LARP) and CERN are developing high-gradient Nb3Sn magnets for the High Luminosity LHC interaction regions. Magnetic measurements of the first 1.5 m long, 150 mm aperture model quadrupole, MQXFS1, were performed during magnet assembly at LBNL, as well as during cryogenic testing at Fermilab’s Vertical Magnet Test Facility. This paper reports on the results of these magnetic characterization measurements, as well as on the performance of new probes developed for the tests.

  11. Magnetic Measurements of the First Nb$_3$Sn Model Quadrupole (MQXFS) for the High-Luminosity LHC

    SciTech Connect

    DiMarco, J.; Ambrosio, G.; Chlachidze, G.; Ferracin, P.; Holik, E.; Sabbi, G.; Stoynev, S.; Strauss, T.; Sylvester, C.; Tartaglia, M.; Todesco, E.; Velev, G.; Wang, X.

    2016-09-06

    The US LHC Accelerator Research Program (LARP) and CERN are developing high-gradient Nb3Sn magnets for the High Luminosity LHC interaction regions. Magnetic measurements of the first 1.5 m long, 150 mm aperture model quadrupole, MQXFS1, were performed during magnet assembly at LBNL, as well as during cryogenic testing at Fermilab’s Vertical Magnet Test Facility. This paper reports on the results of these magnetic characterization measurements, as well as on the performance of new probes developed for the tests.

  12. Co-incident insertion enables high efficiency genome engineering in mouse embryonic stem cells

    PubMed Central

    Shy, Brian R.; MacDougall, Matthew S.; Clarke, Ryan; Merrill, Bradley J.

    2016-01-01

    CRISPR/Cas9 nucleases have enabled powerful, new genome editing capabilities; however, the preponderance of non-homologous end joining (NHEJ) mediated repair events over homology directed repair (HDR) in most cell types limits the ability to engineer precise changes in mammalian genomes. Here, we increase the efficiency of isolating precise HDR-mediated events in mouse embryonic stem (ES) cells by more than 20-fold through the use of co-incidental insertion (COIN) of independent donor DNA sequences. Analysis of on:off-target frequencies at the Lef1 gene revealed that bi-allelic insertion of a PGK-Neo cassette occurred more frequently than expected. Using various selection cassettes targeting multiple loci, we show that the insertion of a selectable marker at one control site frequently coincided with an insertion at an unlinked, independently targeted site, suggesting enrichment of a sub-population of HDR-proficient cells. When individual cell events were tracked using flow cytometry and fluorescent protein markers, individual cells frequently performed either a homology-dependent insertion event or a homology-independent event, but rarely both types of insertions in a single cell. Thus, when HDR-dependent selection donors are used, COIN enriches for HDR-proficient cells among heterogeneous cell populations. When combined with a self-excising selection cassette, COIN provides highly efficient and scarless genome editing. PMID:27484482

  13. Co-incident insertion enables high efficiency genome engineering in mouse embryonic stem cells.

    PubMed

    Shy, Brian R; MacDougall, Matthew S; Clarke, Ryan; Merrill, Bradley J

    2016-09-19

    CRISPR/Cas9 nucleases have enabled powerful, new genome editing capabilities; however, the preponderance of non-homologous end joining (NHEJ) mediated repair events over homology directed repair (HDR) in most cell types limits the ability to engineer precise changes in mammalian genomes. Here, we increase the efficiency of isolating precise HDR-mediated events in mouse embryonic stem (ES) cells by more than 20-fold through the use of co-incidental insertion (COIN) of independent donor DNA sequences. Analysis of on:off-target frequencies at the Lef1 gene revealed that bi-allelic insertion of a PGK-Neo cassette occurred more frequently than expected. Using various selection cassettes targeting multiple loci, we show that the insertion of a selectable marker at one control site frequently coincided with an insertion at an unlinked, independently targeted site, suggesting enrichment of a sub-population of HDR-proficient cells. When individual cell events were tracked using flow cytometry and fluorescent protein markers, individual cells frequently performed either a homology-dependent insertion event or a homology-independent event, but rarely both types of insertions in a single cell. Thus, when HDR-dependent selection donors are used, COIN enriches for HDR-proficient cells among heterogeneous cell populations. When combined with a self-excising selection cassette, COIN provides highly efficient and scarless genome editing. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

  14. Magnetic analysis of the Nb$$_3$$Sn low-beta quadrupole for the high luminosity LHC

    DOE PAGES

    Bermudez, Susana Izquierdo; Ambrosio, G.; Chlachidze, G.; ...

    2017-01-10

    As part of the Large Hadron Collider Luminosity upgrade (HiLumi-LHC) program, the US LARP collaboration and CERN are working together to design and build 150 mm aperture Nb3Sn quadrupoles for the LHC interaction regions. A first series of 1.5 m long coils were fabricated, assembled and tested in the first short model. This paper presents the magnetic analysis, comparing magnetic field measurements with the expectations and the field quality requirements. The analysis is focused on the geometrical harmonics, iron saturation effect and cold-warm correlation. Three dimensional effects such as the variability of the field harmonics along the magnet axis andmore » the contribution of the coil ends are also discussed. Furthemore, we present the influence of the conductor magnetization and the dynamic effects.« less

  15. RelocaTE2: a high resolution transposable element insertion site mapping tool for population resequencing

    PubMed Central

    Chen, Jinfeng; Wrightsman, Travis R.; Wessler, Susan R.

    2017-01-01

    Background Transposable element (TE) polymorphisms are important components of population genetic variation. The functional impacts of TEs in gene regulation and generating genetic diversity have been observed in multiple species, but the frequency and magnitude of TE variation is under appreciated. Inexpensive and deep sequencing technology has made it affordable to apply population genetic methods to whole genomes with methods that identify single nucleotide and insertion/deletion polymorphisms. However, identifying TE polymorphisms, particularly transposition events or non-reference insertion sites can be challenging due to the repetitive nature of these sequences, which hamper both the sensitivity and specificity of analysis tools. Methods We have developed the tool RelocaTE2 for identification of TE insertion sites at high sensitivity and specificity. RelocaTE2 searches for known TE sequences in whole genome sequencing reads from second generation sequencing platforms such as Illumina. These sequence reads are used as seeds to pinpoint chromosome locations where TEs have transposed. RelocaTE2 detects target site duplication (TSD) of TE insertions allowing it to report TE polymorphism loci with single base pair precision. Results and Discussion The performance of RelocaTE2 is evaluated using both simulated and real sequence data. RelocaTE2 demonstrate high level of sensitivity and specificity, particularly when the sequence coverage is not shallow. In comparison to other tools tested, RelocaTE2 achieves the best balance between sensitivity and specificity. In particular, RelocaTE2 performs best in prediction of TSDs for TE insertions. Even in highly repetitive regions, such as those tested on rice chromosome 4, RelocaTE2 is able to report up to 95% of simulated TE insertions with less than 0.1% false positive rate using 10-fold genome coverage resequencing data. RelocaTE2 provides a robust solution to identify TE insertion sites and can be incorporated into

  16. X-ray view of four high-luminosity Swift/BAT AGN: Unveiling obscuration and reflection with Suzaku

    NASA Astrophysics Data System (ADS)

    Fioretti, V.; Angelini, L.; Mushotzky, R. F.; Koss, M.; Malaguti, G.

    2013-07-01

    Aims: A complete census of obscured active galactic nuclei (AGN) is necessary to reveal the history of the super massive black hole (SMBH) growth and galaxy evolution in the Universe given the complex feedback processes and the fact that much of this growth occurs in an obscured phase. In this context, hard X-ray surveys and dedicated follow-up observations represent a unique tool for selecting highly absorbed AGN and for characterizing the obscuring matter surrounding the SMBH. Here we focus on the absorption and reflection occurring in highly luminous, quasar-like AGN, to study the relation between the geometry of the absorbing matter and the AGN nature (e.g. X-ray, optical, and radio properties), and to help to determine the column density dependency on the AGN luminosity. Methods: The Swift/BAT nine-month survey observed 153 AGN, all with ultra-hard X-ray BAT fluxes in excess of 10-11 erg cm-2 s-1 and an average redshift of 0.03. Among them, four of the most luminous BAT AGN (44.73 < Log LBAT < 45.31) were selected as targets of Suzaku follow-up observations: J2246.0+3941 (3C 452), J0407.4+0339 (3C 105), J0318.7+6828, and J0918.5+0425. The column density, scattered/reflected emission, the properties of the Fe K line, and a possible variability are fully analyzed. For the latter, the spectral properties from Chandra, XMM-Newton and Swift/XRT public observations were compared with the present Suzaku analysis, adding an original spectral analysis when none was available from the literature. Results: Of our sample, 3C 452 is the only certain Compton-thick AGN candidate because of i) the high absorption (NH ~ 4 × 1023 cm-2) and strong Compton reflection; ii) the lack of variability; iii) the "buried" nature, i.e. the low scattering fraction (<0.5%) and the extremely low relative [OIII] luminosity. In contrast 3C 105 is not reflection-dominated, despite the comparable column density, X-ray luminosity and radio morphology, but shows a strong long-term variability in

  17. X-ray View of Four High-Luminosity Swift-BAT AGN: Unveiling Obscuration and Reflection with Suzaku

    NASA Technical Reports Server (NTRS)

    Fiorettil, V.; Angelini, L.; Mushotzky, R. F.; Koss, M.; Malaguti, G.

    2013-01-01

    Aims. A complete census of obscured Active Galactic Nuclei (AGN) is necessary to reveal the history of the super massive black hole (SMBH) growth and galaxy evolution in the Universe given the complex feedback processes and the fact that much of this growth occurs in an obscured phase. In this context, hard X-ray surveys and dedicated follow-up observations represent a unique tool for selecting highly absorbed AGN and for characterizing the obscuring matter surrounding the SMBH. Here we focus on the absorption and reflection occurring in highly luminous, quasar-like AGN, to study the relation between the geometry of the absorbing matter and the AGN nature (e.g. X-ray, optical, and radio properties), and to help to determine the column density dependency on the AGN luminosity. Methods. The Swift/BAT nine-month survey observed 153 AGN, all with ultra-hard X-ray BAT fluxes in excess of 10(exp -11) erg per square centimeter and an average redshift of 0.03. Among them, four of the most luminous BAT AGN (44.73 less than LogLBAT less than 45.31) were selected as targets of Suzaku follow-up observations: J2246.0+3941 (3C 452), J0407.4+0339 (3C 105), J0318.7+6828, and J0918.5+0425. The column density, scattered/reflected emission, the properties of the Fe K line, and a possible variability are fully analyzed. For the latter, the spectral properties from Chandra, XMM-Newton and Swift/XRT public observations were compared with the present Suzaku analysis, adding an original spectral analysis when non was available from the literature. Results. Of our sample, 3C 452 is the only certain Compton-thick AGN candidate because of i) the high absorption (N(sub H) approximately 4 × 10(exp 23) per square centimeter) and strong Compton reflection; ii) the lack of variability; iii) the "buried" nature, i.e. the low scattering fraction (less than 0.5%) and the extremely low relative [OIII] luminosity. In contrast 3C 105 is not reflection-dominated, despite the comparable column density

  18. Pile up management at the high-luminosity LHC and introduction to the crab-kissing concept

    NASA Astrophysics Data System (ADS)

    Fartoukh, Stéphane

    2014-11-01

    Upgrading the integrated performance of the LHC, while preserving the quality of the physics data delivered to the experiments, is a real challenge for the high luminosity LHC (HL-LHC). This paper will give an overview of the situation in terms of performance and so-called pile up density which directly impacts on the reconstruction efficiency of the primary vertices at the interaction point. Both the present HL-LHC baseline and its possible extension with the so-called crab-kissing scheme will be discussed in this context.

  19. RHIC LUMINOSITY UPGRADE PROGRAM

    SciTech Connect

    Fischer, W.

    2010-05-23

    The Relativistic Heavy Ion Collider (RHIC) operates with either ions or polarized protons. After increasing the heavy ion luminosity by two orders of magnitude since its commissioning in 2000, the current luminosity upgrade program aims for an increase by another factor of 4 by means of 3D stochastic cooling and a new 56 MHz SRF system. An Electron Beam Ion Source is being commissioned that will allow the use of uranium beams. Electron cooling is considered for collider operation below the current injection energy. For the polarized proton operation both luminosity and polarization are important. In addition to ongoing improvements in the AGS injector, the construction of a new high-intensity polarized source has started. In RHIC a number of upgrades are under way to increase the intensity and polarization transmission to 250 GeV beam energy. Electron lenses will be installed to partially compensate the head-on beam-beam effect.

  20. Upgrade of the ATLAS Tile hadronic calorimeter for high-luminosity LHC run

    NASA Astrophysics Data System (ADS)

    Spoor, Matthew

    2017-02-01

    The ATLAS Tile Calorimeter (TileCal) will undergo a major replacement of its on- and off-detector electronics for the Long Shutdown 3 that is planned for 2024 and 2025. All signals will be digitised and transferred directly to the off-detector electronics, where the signals are reconstructed, stored, and sent to the first level of trigger at a rate of 40 MHz. This will provide better precision of the calorimeter signals used by the trigger system and will allow the development of more complex trigger algorithms. Changes to the electronics will also contribute to the reliability and redundancy of the system. Three different front-end options are presently being investigated for the upgrade and will be chosen after extensive test beam studies. A Hybrid Demonstrator module has been developed. The demonstrator is undergoing extensive testing and is planned for insertion in ATLAS.

  1. ESSENTIALS: software for rapid analysis of high throughput transposon insertion sequencing data.

    PubMed

    Zomer, Aldert; Burghout, Peter; Bootsma, Hester J; Hermans, Peter W M; van Hijum, Sacha A F T

    2012-01-01

    High-throughput analysis of genome-wide random transposon mutant libraries is a powerful tool for (conditional) essential gene discovery. Recently, several next-generation sequencing approaches, e.g. Tn-seq/INseq, HITS and TraDIS, have been developed that accurately map the site of transposon insertions by mutant-specific amplification and sequence readout of DNA flanking the transposon insertions site, assigning a measure of essentiality based on the number of reads per insertion site flanking sequence or per gene. However, analysis of these large and complex datasets is hampered by the lack of an easy to use and automated tool for transposon insertion sequencing data. To fill this gap, we developed ESSENTIALS, an open source, web-based software tool for researchers in the genomics field utilizing transposon insertion sequencing analysis. It accurately predicts (conditionally) essential genes and offers the flexibility of using different sample normalization methods, genomic location bias correction, data preprocessing steps, appropriate statistical tests and various visualizations to examine the results, while requiring only a minimum of input and hands-on work from the researcher. We successfully applied ESSENTIALS to in-house and published Tn-seq, TraDIS and HITS datasets and we show that the various pre- and post-processing steps on the sequence reads and count data with ESSENTIALS considerably improve the sensitivity and specificity of predicted gene essentiality.

  2. ESSENTIALS: Software for Rapid Analysis of High Throughput Transposon Insertion Sequencing Data

    PubMed Central

    Zomer, Aldert; Burghout, Peter; Bootsma, Hester J.; Hermans, Peter W. M.; van Hijum, Sacha A. F. T.

    2012-01-01

    High-throughput analysis of genome-wide random transposon mutant libraries is a powerful tool for (conditional) essential gene discovery. Recently, several next-generation sequencing approaches, e.g. Tn-seq/INseq, HITS and TraDIS, have been developed that accurately map the site of transposon insertions by mutant-specific amplification and sequence readout of DNA flanking the transposon insertions site, assigning a measure of essentiality based on the number of reads per insertion site flanking sequence or per gene. However, analysis of these large and complex datasets is hampered by the lack of an easy to use and automated tool for transposon insertion sequencing data. To fill this gap, we developed ESSENTIALS, an open source, web-based software tool for researchers in the genomics field utilizing transposon insertion sequencing analysis. It accurately predicts (conditionally) essential genes and offers the flexibility of using different sample normalization methods, genomic location bias correction, data preprocessing steps, appropriate statistical tests and various visualizations to examine the results, while requiring only a minimum of input and hands-on work from the researcher. We successfully applied ESSENTIALS to in-house and published Tn-seq, TraDIS and HITS datasets and we show that the various pre- and post-processing steps on the sequence reads and count data with ESSENTIALS considerably improve the sensitivity and specificity of predicted gene essentiality. PMID:22900082

  3. Lyman-Break Galaxies at z>~4 and the Evolution of the Ultraviolet Luminosity Density at High Redshift

    NASA Astrophysics Data System (ADS)

    Steidel, Charles C.; Adelberger, Kurt L.; Giavalisco, Mauro; Dickinson, Mark; Pettini, Max

    1999-07-01

    We present initial results of a survey for star-forming galaxies in the redshift range 3.8<~z<~4.5. This sample consists of a photometric catalog of 244 galaxies culled from a total solid angle of 0.23 deg2 to an apparent magnitude of IAB=25.0. Spectroscopic redshifts in the range 3.61<=z<=4.81 have been obtained for 48 of these galaxies; their median redshift is =4.13. Selecting these galaxies in a manner entirely analogous to our large survey for Lyman-break galaxies at smaller redshift (2.7<~z<~3.4) allows a relatively clean differential comparison between the populations and integrated luminosity density at these two cosmic epochs. Over the same range of UV luminosity, the spectroscopic properties of the galaxy samples at z~4 and z~3 are indistinguishable, as are the luminosity function shapes and the total integrated UV luminosity densities [ρUV(z=3)/ρUV(z=4)=1.1+/-0.3]. We see no evidence at these bright magnitudes for the steep decline in the star formation density inferred from fainter photometric Lyman-break galaxies in the Hubble deep field (HDF). The HDF provides the only existing data on Lyman-break galaxy number densities at fainter magnitudes. We have reanalyzed the z~3 and z~4 Lyman-break galaxies in the HDF using our improved knowledge of the spectral energy distributions of these galaxies, and we find, like previous authors, that faint Lyman-break galaxies appear to be rarer at z~4 than z~3. This might signal a large change in the faint-end slope of the Lyman-break galaxy luminosity function between redshifts z~3 and z~4, or, more likely, be due to significant variance in the number counts within the small volumes probed by the HDF at high redshifts (~160 times smaller than the ground-based surveys discussed here). If the true luminosity density at z~4 is somewhat higher than implied by the HDF, as our ground-based sample suggests, then the emissivity of star formation as a function of redshift would appear essentially constant for all z>1

  4. Evaluation of insert earphones for high-frequency bedside ototoxicity monitoring.

    PubMed

    Gordon, Jane S; Phillips, David S; Helt, Wendy J; Konrad-Martin, Dawn; Fausti, Stephen A

    2005-01-01

    Ototoxic hearing loss is usually detected earliest through monitoring of the highest audible frequencies in individuals administered ototoxic medications. Conducting ototoxicity monitoring may require testing patients in the hospital room. This study evaluated the use of insert earphones for obtaining reliable threshold responses at bedside. Twenty adult subjects were tested during two different sessions in the sound booth and on the ward. Thresholds were obtained for frequencies from 5 to 16 kHz and at 2 kHz with the use of the KOSS Pro/4X Plus earphones and Etymotic ER-4B MicroPro insert earphones. Results indicate that ER-4B insert earphones are as reliable as KOSS earphones for testing on the ward for high-frequency ototoxicity monitoring.

  5. On the faint-end of the high-z galaxy luminosity function

    NASA Astrophysics Data System (ADS)

    Yue, Bin; Ferrara, Andrea; Xu, Yidong

    2016-12-01

    Recent measurements of the luminosity function (LF) of galaxies in the Epoch of Reionization (EoR, z ≳ 6) indicate a very steep increase of the number density of low-mass galaxies populating the LF faint-end. However, as star formation in low-mass haloes can be easily depressed or even quenched by ionizing radiation, a turnover is expected at some faint UV magnitudes. Using a physically motivated analytical model, we quantify reionization feedback effects on the LF faint-end shape. We find that if reionization feedback is neglected, the power-law Schechter parametrization characterizing the LF faint-end remains valid up to absolute UV magnitude ˜-9. If instead radiative feedback is strong enough that quenches star formation in haloes with circular velocity smaller than 50 km s-1, the LF starts to drop at absolute UV magnitude ˜-15, i.e. slightly below the detection limits of current (unlensed) surveys at z ˜ 5. The LFs may rise again at higher absolute UV magnitude, where, as a result of interplay between reionization process and galaxy formation, most of the galaxy light is from relic stars formed before the EoR. We suggest that the galaxy number counts data, particularly in lensed fields, can put strong constraints on reionization feedback. In models with stronger reionization feedback, stars in galaxies with absolute UV magnitude higher than ˜-13 and smaller than ˜-8 are typically older. Hence, the stellar age-UV magnitude relation can be used as an alternative feedback probe.

  6. Compton Scattering in Clinical PET/CT With High Resolution Half Ring PET Insert Device

    PubMed Central

    Komarov, Sergey A.; Wu, Heyu; Keesing, Daniel B.; O'Sullivan, Joseph A.; Tai, Yuan-Chuan

    2011-01-01

    The integration of a high resolution PET insert into a conventional PET system can significantly improve the resolution and the contrast of its images within a reduced imaging field of view. For the rest of the scanner imaging field of view, the insert is a highly attenuating and scattering media. In order to use all available coincidence events (including coincidences between 2 detectors in the original scanner, namely the scanner-scanner coincidences), appropriate scatter and attenuation corrections have to be implemented. In this work, we conducted a series of Monte Carlo simulations to estimate the composition of the scattering background and the importance of the scatter correction. We implemented and tested the Single Scatter Simulation (SSS) algorithm for a hypothetical system and show good agreement between the estimated scatter using SSS and Monte Carlo simulated scatter contribution. We further applied the SSS to estimate scatter contribution from an existing prototype PET insert for a clinical PET/CT scanner. The results demonstrated the applicability of SSS to estimate the scatter contribution within a clinical PET/CT system even when there is a high resolution half ring PET insert device in its imaging field of view. PMID:21552470

  7. Meta-Analysis of Correlations Between Marginal Bone Resorption and High Insertion Torque of Dental Implants.

    PubMed

    Li, Haoyan; Liang, Yongqiang; Zheng, Qiang

    2015-01-01

    To evaluate correlations between marginal bone resorption and high insertion torque value (> 50 Ncm) of dental implants and to assess the significance of immediate and early/conventional loading of implants under a certain range torque value. Specific inclusion and exclusion criteria were used to retrieve eligible articles from Ovid, PubMed, and EBSCO up to December 2013. Screening of eligible studies, quality assessment, and data extraction were conducted in duplicate. The results were expressed as random/fixed-effects models using weighted mean differences for continuous outcomes with 95% confidence intervals. Initially, 154 articles were selected (11 from Ovid, 112 from PubMed, and 31 from EBSCO). After exclusion of duplicate articles and articles that did not meet the inclusion criteria, six clinical studies were selected. Assessment of P values revealed that correlations between marginal bone resorption and high insertion torque were not statistically significant and that there was no difference between immediately versus early/conventionally loaded implants under a certain range of torque. None of the meta-analyses revealed any statistically significant differences between high insertion torque and conventional insertion torque in terms of effects on marginal bone resorption.

  8. Mechanical Analysis of the 400 MHz RF-Dipole Crabbing Cavity Prototype for LHC High Luminosity Upgrade

    SciTech Connect

    De Silva, Subashini U.; Park, HyeKyoung; Delayen, Jean R.; Li, Z.

    2013-12-01

    The proposed LHC high luminosity upgrade requires two crabbing systems in increasing the peak luminosity, operating both vertically and horizontally at two interaction points of IP1 and IP5. The required system has tight dimensional constraints and needs to achieve higher operational gradients. A proof-of-principle 400 MHz crabbing cavity design has been successfully tested and has proven to be an ideal candidate for the crabbing system. The cylindrical proof-of-principle rf-dipole design has been adapted in to a square shaped design to further meet the dimensional requirements. The new rf-dipole design has been optimized in meeting the requirements in rf-properties, higher order mode damping, and multipole components. A crabbing system in a cryomodule is expected to be tested on the SPS beam line prior to the test at LHC. The new prototype is required to achieve the mechanical and thermal specifications of the SPS test followed by the test at LHC. This paper discusses the detailed mechanical and thermal analysis in minimizing Lorentz force detuning and sensitivity to liquid He pressure fluctuations.

  9. High-luminosity primary vertex selection in top-quark studies using the Collider Detector at Fermilab

    SciTech Connect

    Buzatu, Adrian; /McGill U.

    2006-08-01

    Improving our ability to identify the top quark pair (t{bar t}) primary vertex (PV) on an event-by-event basis is essential for many analyses in the lepton-plus-jets channel performed by the Collider Detector at Fermilab (CDF) Collaboration. We compare the algorithm currently used by CDF (A1) with another algorithm (A2) using Monte Carlo simulation at high instantaneous luminosities. We confirm that A1 is more efficient than A2 at selecting the t{bar t} PV at all PV multiplicities, both with efficiencies larger than 99%. Event selection rejects events with a distance larger than 5 cm along the proton beam between the t{bar t} PV and the charged lepton. We find flat distributions for the signal over background significance of this cut for all cut values larger than 1 cm, for all PV multiplicities and for both algorithms. We conclude that any cut value larger than 1 cm is acceptable for both algorithms under the Tevatron's expected instantaneous luminosity improvements.

  10. Conceptual Design of the Cryogenic System for the High-luminosity Upgrade of the Large Hadron Collider (LHC)

    NASA Astrophysics Data System (ADS)

    Brodzinski, K.; Claudet, S.; Ferlin, G.; Tavian, L.; Wagner, U.; Van Weelderen, R.

    The discovery of a Higgs boson at CERN in 2012 is the start of a major program of work to measure this particle's properties with the highest possible precision for testing the validity of the Standard Model and to search for further new physics at the energy frontier. The LHC is in a unique position to pursue this program. Europe's top priority is the exploitation of the full potential of the LHC, including the high-luminosity upgrade of the machine and detectors with an objective to collect ten times more data than in the initial design, by around 2030. To reach this objective, the LHC cryogenic system must be upgraded to withstand higher beam current and higher luminosity at top energy while keeping the same operation availability by improving the collimation system and the protection of electronics sensitive to radiation. This paper will present the conceptual design of the cryogenic system upgrade with recent updates in performance requirements, the corresponding layout and architecture of the system as well as the main technical challenges which have to be met in the coming years.

  11. Medially-shifted rather than high-riding vertebral arteries preclude safe pedicle screw insertion.

    PubMed

    Maki, Satoshi; Koda, Masao; Iijima, Yasushi; Furuya, Takeo; Inada, Taigo; Kamiya, Koshiro; Ota, Mitsutoshi; Saito, Junya; Okawa, Akihiko; Takahashi, Kazuhisa; Yamazaki, Masashi

    2016-07-01

    We enrolled 100 patients who underwent preoperative CT angiography before cervical spine instrumentation and investigated the morphology of the C2 pedicle from the perspective of pedicle screw (PS) trajectory using volume rendering and multiplanar reconstruction. The narrowest portion of the pedicle was identified as the pedicle isthmus. Safe C2 PS insertion was regarded to be not feasible when the height of the medullary cavity of the pedicle isthmus and/or width of the medullary cavity of the pedicle isthmus was ⩽4mm. Forty-five (22.5%) pedicles were ⩽4mm in width, and safe insertion of a PS was determined to be not feasible. Among these, seven pedicles were ⩽4mm in both height and width. The remaining 38 pedicles were ⩽4mm in width with heights >4mm. There was no pedicle with a width >4mm and height <4mm. In other words, short pedicles were always concomitantly narrow. Therefore, the seven pedicles ⩽4mm in both height and width were considered to be morphologically narrow. The heights of the pedicle isthmus were not limited by the vertebral artery groove (VAG) and safe C2 PS insertion can be considered feasible where the VAG is marginally cranial, whereas the widths of the pedicle isthmus are limited by the VAG. Therefore, safe C2 PS insertion is precluded only when the VAG courses cranially and medially. It is a medially-shifted, rather than a high-riding, vertebral artery that precludes safe C2 PS insertion. Therefore to avoid vertebral artery injury an axial CT scan, parallel to the pedicle axis, should be evaluated before C2 PS insertion.

  12. High luminosity, slow ejecta and persistent carbon lines: SN 2009dc challenges thermonuclear explosion scenarios

    NASA Astrophysics Data System (ADS)

    Taubenberger, S.; Benetti, S.; Childress, M.; Pakmor, R.; Hachinger, S.; Mazzali, P. A.; Stanishev, V.; Elias-Rosa, N.; Agnoletto, I.; Bufano, F.; Ergon, M.; Harutyunyan, A.; Inserra, C.; Kankare, E.; Kromer, M.; Navasardyan, H.; Nicolas, J.; Pastorello, A.; Prosperi, E.; Salgado, F.; Sollerman, J.; Stritzinger, M.; Turatto, M.; Valenti, S.; Hillebrandt, W.

    2011-04-01

    Extended optical and near-IR observations reveal that SN 2009dc shares a number of similarities with normal Type Ia supernovae (SNe Ia), but is clearly overluminous, with a (pseudo-bolometric) peak luminosity of log (L) = 43.47 (erg s-1). Its light curves decline slowly over half a year after maximum light [Δm15(B)true= 0.71], and the early-time near-IR light curves show secondary maxima, although the minima between the first and the second peaks are not very pronounced. The bluer bands exhibit an enhanced fading after ˜200 d, which might be caused by dust formation or an unexpectedly early IR catastrophe. The spectra of SN 2009dc are dominated by intermediate-mass elements and unburned material at early times, and by iron-group elements at late phases. Strong C II lines are present until ˜2 weeks past maximum, which is unprecedented in thermonuclear SNe. The ejecta velocities are significantly lower than in normal and even subluminous SNe Ia. No signatures of interaction with a circumstellar medium (CSM) are found in the spectra. Assuming that the light curves are powered by radioactive decay, analytic modelling suggests that SN 2009dc produced ˜1.8 M⊙ of 56Ni assuming the smallest possible rise time of 22 d. Together with a derived total ejecta mass of ˜2.8 M⊙, this confirms that SN 2009dc is a member of the class of possible super-Chandrasekhar-mass SNe Ia similar to SNe 2003fg, 2006gz and 2007if. A study of the hosts of SN 2009dc and other superluminous SNe Ia reveals a tendency of these SNe to explode in low-mass galaxies. A low metallicity of the progenitor may therefore be an important prerequisite for producing superluminous SNe Ia. We discuss a number of possible explosion scenarios, ranging from super-Chandrasekhar-mass white-dwarf progenitors over dynamical white-dwarf mergers and Type I? SNe to a core-collapse origin of the explosion. None of the models seems capable of explaining all properties of SN 2009dc, so that the true nature of this SN

  13. Environments of High Luminosity X-Ray Sources in the Antennae Galaxies

    NASA Astrophysics Data System (ADS)

    Clark, D. M.; Eikenberry, S. S.; Brandl, B. R.; Wilson, J. C.; Carson, J. C.; Henderson, C. P.; Hayward, T. P.; Barry, D. J.; Houck, J. R.; Ptak, A.; Colbert, E.

    2003-12-01

    We use deep J (1.25 μ m) and Ks (2.15 μ m) images of the Antennae (NGC 4038/9) obtained with the Wide-field InfraRed Camera on the Palomar 200-inch telescope, together with the Chandra X-ray source list of Zezas et al. (2001), to establish an X-ray/IR astrometric frame tie with ˜ 0.5 ″ RMS residuals over a ˜ 5 ‧ field. We find 13 ``strong" IR counterparts <1.0 ″ from X-ray sources, and an additional 6 ``possible" IR counterparts between 1.0 ″ and 1.5 ″ from X-ray sources. Based on detailed study of the surface density of IR sources near the X-ray sources, we expect only ˜ 2 of the ``strong" counterparts and ˜ 3 of the ``possible" counterparts to be chance superpositions of unrelated objects. Comparing the IR counterparts to our photometric study of ˜ 250 IR clusters in the Antennae, we find that IR counterparts to X-ray sources are Δ MK ˜ 1.2 mag more luminous than average non-X-ray clusters (>99.9% confidence), and that the X-ray/IR matches are concentrated in the spiral arms and ``bridge" regions of the Antennae. This implies that these X-ray sources lie in the most ``super" of the Antennae's Super Star Clusters, and thus trace the recent massive star formation history here. Based on the NH inferred from the X-ray sources without IR counterparts, we determine that the absence of most of the ``missing" IR counterparts is not due to extinction, but that these sources are intrinsically less luminous in the IR, implying that they trace a different (older?) stellar population. We find no clear correlation between X-ray luminosity classes and IR properties of the sources, though small number statistics hamper this analysis. Finally, we find a Ks = 16.2 mag counterpart to the Ultra-Luminous X-ray (ULX) source X-37 within <0.5 ″ , eliminating the need for the ``runaway binary" hypothesis proposed by previous authors for this object. We discuss some of the implications of this detection for models of ULX emission. This work is funded by an NSF CAREER

  14. Dedicated mobile high resolution prostate PET imager with an insertable transrectal probe

    DOEpatents

    Majewski, Stanislaw; Proffitt, James

    2010-12-28

    A dedicated mobile PET imaging system to image the prostate and surrounding organs. The imaging system includes an outside high resolution PET imager placed close to the patient's torso and an insertable and compact transrectal probe that is placed in close proximity to the prostate and operates in conjunction with the outside imager. The two detector systems are spatially co-registered to each other. The outside imager is mounted on an open rotating gantry to provide torso-wide 3D images of the prostate and surrounding tissue and organs. The insertable probe provides closer imaging, high sensitivity, and very high resolution predominately 2D view of the prostate and immediate surroundings. The probe is operated in conjunction with the outside imager and a fast data acquisition system to provide very high resolution reconstruction of the prostate and surrounding tissue and organs.

  15. The design and simulated performance of a fast Level 1 track trigger for the ATLAS High Luminosity Upgrade

    NASA Astrophysics Data System (ADS)

    Mårtensson, Mikael

    2017-08-01

    The ATLAS experiment at the High Luminosity LHC will face a fivefold increase in the number of interactions per bunch crossing relative to the ongoing Run 2. This will require a proportional improvement in rejection power at the earliest levels of the detector trigger system, while preserving good signal efficiency. One critical aspect of this improvement will be the implementation of precise track reconstruction, through which sharper trigger turn-on curves can be achieved, and b-tagging and tau-tagging techniques can in principle be implemented. The challenge of such a project comes in the development of a fast, custom electronic device integrated in the hardware based first trigger level of the experiment. This article will discuss the requirements, architecture and projected performance of the system in terms of tracking, timing and physics, based on detailed simulations. Studies are carried out using data from the strip subsystem only or both strip and pixel subsystems.

  16. Mitigation of effects of beam-induced energy deposition in the LHC high-luminosity interaction regions

    SciTech Connect

    Nikolai V. Mokhov et al.

    2003-05-28

    Beam-induced energy deposition in the LHC high luminosity interaction region components is one of the serious limits for the machine performance. The results of further optimization and comprehensive MARS14 calculations in the IP1 and IP5 inner and outer triplets are summarized for the updated lattice, calculation model, baseline pp-collision source term, and for realistic engineering constraints on the hardware design. It is shown that the optimized layout and absorbers would provide a sufficient reduction of peak power density and dynamic heat load in the superconducting components with an adequate safety margin. Accumulated dose and residual dose rates in and around the region components are also kept below the tolerable limits in the proposed design.

  17. Development of edgeless silicon pixel sensors on p-type substrate for the ATLAS high-luminosity upgrade

    NASA Astrophysics Data System (ADS)

    Calderini, G.; Bagolini, A.; Bomben, M.; Boscardin, M.; Bosisio, L.; Chauveau, J.; Giacomini, G.; La Rosa, A.; Marchiori, G.; Zorzi, N.

    2014-11-01

    In view of the LHC upgrade for the high luminosity phase (HL-LHC), the ATLAS experiment is planning to replace the inner detector with an all-silicon system. The n-in-p bulk technology represents a valid solution for the modules of most of the layers, given the significant radiation hardness of this option and the reduced cost. The large area necessary to instrument the outer layers will demand to tile the sensors, a solution for which the inefficient region at the border of each sensor needs to be reduced to the minimum size. This paper reports on a joint R&D project by the ATLAS LPNHE Paris group and FBK Trento on a novel n-in-p edgeless planar pixel design, based on the deep-trench process available at FBK.

  18. Development of Edgeless Silicon Pixel Sensors on p-type substrate for the ATLAS High-Luminosity Upgrade

    NASA Astrophysics Data System (ADS)

    Calderini, G.; Bagolini, A.; Beccherle, R.; Bomben, M.; Boscardin, M.; Bosisio, L.; Chauveau, J.; Giacomini, G.; La Rosa, A.; Marchiori, G.; Zorzi, N.

    2016-09-01

    In view of the LHC upgrade phases towards the High Luminosity LHC (HL-LHC), the ATLAS experiment plans to upgrade the Inner Detector with an all-silicon system. The n-on-p silicon technology is a promising candidate to achieve a large area instrumented with pixel sensors, since it is radiation hard and cost effective. The presentation describes the performance of novel n-in-p edgeless planar pixel sensors produced by FBK-CMM, making use of the active trench for the reduction of the dead area at the periphery of the device. After discussing the sensor technology, some feedback from preliminary results of the first beam test will be discussed.

  19. Errata: A Wide-Field Multicolor Survey for High-Redshift Quasars, Z >= 2.2. III. The Luminosity Function

    NASA Astrophysics Data System (ADS)

    Warren, Stephen J.; Hewett, Paul C.; Osmer, Patrick S.

    1995-01-01

    In the paper "A Wide-Field Multicolor Survey for High-Redshift Quasars, z >= 2.2. III. The Luminosity Function" by Stephen. Warren, Paul C. Hewett and Patrick S. Osmer (ApJ, 421,412 [1994]), two equations should be corrected: On page 419, column one, line 11, the expression following the words "the error,, should have an opening parenthesis just before the integral sign, to read: [{SIGMA} 1/({integral} ρ(z)dV_a_)^2^]^1/2^. On page 421, equation (15) is missing the asterisk (*) in the M_c_^*^ term just prior to (β + 1); that is, the exponent in the second term the denominator should read: 0.4(M_c_ - M_c_^*^)(β + 1). The authors wish to draw these errors to the attention of any readers who will be using the expression and equation.

  20. Clinical outcome of dental implants placed with high insertion torques (up to 176 Ncm).

    PubMed

    Khayat, Philippe G; Arnal, Hélène M; Tourbah, Bahige I; Sennerby, Lars

    2013-04-01

    Primary stability can be improved by using a tapered implant in a slightly underprepared implant site. This may lead to high compression forces and elevated insertion torques. It has been postulated that disturbance of the local microcirculation may occur, leading to necrosis of the osteocytes and bone resorption. Report on the clinical outcome of 42 implants placed with an insertion torque equal or greater than 70 Ncm and evaluate bone levels around these implants. This prospective study included 48 patients treated with 66 4.5 mm diameter Tapered Screw-Vent implants (Zimmer Dental®, Carlsbad, CA, USA). Maximum insertion torque (MIT) was recorded with an electronic torque measuring device (Tohnichi® STC200CN, Hitachi, Tokyo, Japan). Nine implants (control group) presented MIT between 30 and 50 Ncm (mean = 37.1 Ncm) and 42 implants (experimental group) MIT greater than 70 Ncm (mean = 110.6 Ncm, range: 70.8-176 Ncm). Marginal bone levels were recorded at the time of loading and 1 year later for the two groups. After 2-3 months of non-sumerged healing, all implants were clinically stable. Mean marginal bone resorption was 1.03 mm (SD = 0.44) for the control group (low torque) and 0.72 mm (SD = 0.56) for the experimental group (high torque) at time of loading, and 1.09 (SD = 0.62) and 1.24 mm (SD = 0.75), respectively, after 1 year. There were no significant differences between the two groups for bone stability and implant success rate. The use of high insertion torques (up to 176 Ncm) did not prevent osseointegration. Marginal bone levels in the control and experimental groups were similar both at the time of loading and 1 year later. © 2011 Wiley Periodicals, Inc.

  1. HVCMOS Monolithic Sensors for the High Luminosity Upgrade of ATLAS Experiment

    NASA Astrophysics Data System (ADS)

    Blanco, R.; Zhang, H.; Krämer, C.; Ehrler, F.; Schimassek, R.; Casanova Mohr, R.; Vilella Figueras, E.; Guezzi Messaoud, F.; Leys, R.; Prathapan, M.; Weber, A.; Perić, I.

    2017-04-01

    This paper describes several monolithic pixel detector designs implemented in a high-voltage CMOS technology. The total size of all chips is 1cm × 1cm. The pixel matrices are distinguished by the readout cell type, the pixel type and the pixel address multiplexing. Design details and first measurement results are described.

  2. Upgrades to the CMS Cathode Strip Chambers for 2017 and the High Luminosity LHC

    NASA Astrophysics Data System (ADS)

    Morse, David; CMS Collaboration

    2017-01-01

    An overview will be given of upgrades to the CMS Cathode Strip Chambers (CSC) during the extended technical stop 2016-2017 and plans for future upgrades targeting the HL-LHC. HL-LHC conditions will surpass the physical capabilities of the present detector, and require novel hardware to cope with increased rates and maintain the high performance of the CSC achieved up to now.

  3. Mechanical effects of high density polyethylene dynamic compression plate hole inserts on bone-plate constructs.

    PubMed

    Sullivan, E K; Nunamaker, D M; Richardson, D W

    2005-01-01

    This study was conducted in order to investigate the mechanical effects of high density polyethylene screw hole inserts in 4.5 mm Dynamic Compression Plate (DCP)--synthetic bone constructs. A mid-shaft 'osteotomy' was created in synthetic bone cylinders. The bisecting 'osteotomy' was reduced using six-hole broad DCPs and 4.5 mm cortical bone screws. The screws adjacent to the 'osteotomy' were placed using a load-guide. The remaining screws were placed in neutral position. High density polyethylene DCP screw hole inserts were incorporated with each screw in neutral position, in the experimental group. The bone plate constructs were tested in four point cyclical bending with the plates loaded at 2,000 Newtons, for a total of 6,000 cycles. Osteotomy gap was measured at 3,000 and 6,000 cycles. Screw head deflection adjacent to the osteotomy was measured. Kruskal-Wallis non-parametric testing was used for statistical comparisons. There was significantly less gapping at the osteotomy site in the treatment group after 3,000 cycles (0.49 +/- 0.18 mm [control] vs. 0.06 +/- 0.14 mm [treated], P=0.02) and 6,000 cycles (0.6 +/- 0.18 mm [control] vs. 0.1 +/- 0.22 mm [treated], P=0.02). The screws adjacent to the gap were significantly more deformed in the control group than those in the treated constructs (3.63 +/- 1.81 [control] vs. 1.06 +/- 1.55 [treated], P=0.0002). The polyethylene inserts improved the interface between bone plate and screw head, resulting in decreased relative movement of the implant and bone. The polyethylene inserts also resulted in less bending of the loaded screws.

  4. Magnetic Design of a High Gradient Quadrupole for the LHC Low-β Insertions.

    NASA Astrophysics Data System (ADS)

    Sabbi, G.; Gourlay, S. A.; Kerby, J.; Lamm, M. J.; Limon, P. J.; Nobrega, F.; Novitski, I.; Strait, J. B.; Zlobin, A. V.; Caspi, S.; Scanlan, R.; Ghosh, A.; Gupta, R.

    1997-05-01

    In order to achieve a luminosity in excess of 10^34 cm-2s-1 at the LHC, special quadrupole magnets are required for the final focusing triplet. These magnets must provide a high field gradient of 235 T/m over a 70 mm aperture, with a good margin in order to safely withstand the heavy radiation load due to secondary particles from beam-beam collisions. At the same time, due to large and rapidly varying values of the β-function, a high field quality is also required. To meet these severe constraints, a design based on a 2-layer coil geometry has been proposed. The magnet uses SSC-type NbTi superconducting strands and operates in superfluid helium. In this paper a description of the magnetic design is given, including short sample performance limits, sources and expected values of systematic and random field errors, and possible strategies for field quality correction.

  5. AC loss evaluation of an HTS insert for high field magnet cooled by cryocoolers

    NASA Astrophysics Data System (ADS)

    Kajikawa, Kazuhiro; Awaji, Satoshi; Watanabe, Kazuo

    2016-12-01

    AC losses in a high temperature superconducting (HTS) insert coil for 25-T cryogen-free superconducting magnet during its initial energization are numerically calculated under the assumption of slab approximation. The HTS insert consisting of 68 single pancakes wound using coated conductors generates a central magnetic field of 11.5 T in addition to the contribution of 14.0 T from a set of low temperature superconducting (LTS) outsert coils. Both the HTS insert and the LTS coils are cooled using cryocoolers, and energized simultaneously up to the central field of 25.5 T with a constant ramp rate for 60 min. The influences of the magnitudes and orientations of locally applied magnetic fields, magnetic interactions between turns and transport currents flowing in the windings are taken into account in the calculations of AC losses. The locally applied fields are separated into axial and radial components, and the individual contributions of these field components to the AC losses are simply summed up to obtain the total losses. The AC losses due to the axial fields become major in the beginning of energization, whereas the total losses monotonically increase with time after the AC losses due to the radial fields become major.

  6. Effect of insertion method on knoop hardness of high viscous glass ionomer cements.

    PubMed

    Raggio, Daniela Prócida; Bonifácio, Clarissa Calil; Bönecker, Marcelo; Imparato, José Carlos P; Gee, Anton J de; Amerongen, Willem Evert van

    2010-01-01

    The aim of this study was to assess the Knoop hardness of three high viscous glass ionomer cements: G1 - Ketac Molar; G2 - Ketac Molar Easymix (3M ESPE) and G3 - Magic Glass ART (Vigodent). As a parallel goal, three different methods for insertion of Ketac Molar Easymix were tested: G4 - conventional spatula; G5 - commercial syringe (Centrix) and G6 - low-cost syringe. Ten specimens of each group were prepared and the Knoop hardness was determined 5 times on each specimen with a HM-124 hardness machine (25 g/30 s dwell time) after 24 h, 1 and 2 weeks. During the entire test period, the specimens were stored in liquid paraffin at 37ºC. Significant differences were found between G3 and G1/G2 (two-way ANOVA and Tukey's post hoc test; p<0.01). There was no significant difference in the results among the multiple ways of insertion. The glass ionomer cement Magic Glass ART showed the lowest hardness, while the insertion technique had no significant influence on hardness.

  7. Simulations of planar pixel sensors for the ATLAS high luminosity upgrade

    NASA Astrophysics Data System (ADS)

    Calderini, G.; Benoit, M.; Dinu, N.; Lounis, A.; Marchiori, G.

    2011-04-01

    A physics-based device simulation was used to study the charge carrier distribution and the electric field configuration inside simplified two-dimensional models for pixel layouts based on the ATLAS pixel sensor. In order to study the behavior of such detectors under different levels of irradiation, a three-level defect model was implemented into the simulation. Using these models, the number of guard rings, the dead edge width and the detector thickness were modified to investigate their influence on the detector depletion at the edge and on its internal electric field distribution in order to optimize the layout parameters. Simulations indicate that the number of guard rings can be reduced by a few hundred microns with respect to the layout used for the present ATLAS sensors, with a corresponding extension of the active area of the sensors. A study of the inter-pixel capacitance and of the capacitance between the implants and the high-voltage contact as a function of several parameters affecting the geometry and the doping level of the implants was also carried out. The results are needed in order to evaluate the noise and the cross-talk among neighboring pixels when connected to the front-end electronics.

  8. THE ELECTRON ION COLLIDER. A HIGH LUMINOSITY PROBE OF THE PARTONIC SUBSTRUCTURE OF NUCLEONS AND NUCLEI.

    SciTech Connect

    EDITED BY M.S. DAVIS

    2002-02-01

    By the end of this decade, the advancement of current and planned research into the fundamental structure of matter will require a new facility, the Electron Ion Collider (EIC). The EIC will collide high-energy beams of polarized electrons from polarized protons and neutrons, and unpolarized beams of electrons off atomic nuclei with unprecedented intensity. Research at the EIC will lead to a detailed understanding of the structure of the proton, neutron, and atomic nuclei as described by Quantum Chromo-Dynamics (QCD), the accepted theory of the strong interaction. The EIC will establish quantitative answers to important questions by delivering dramatically increased precision over existing and planned experiments and by providing completely new experimental capabilities. Indeed, the EIC will probe QCD in a manner not possible previously. This document presents the scientific case for the design, construction and operation of the EIC. While realization of the EIC requires a significant advance in the development of efficient means of producing powerful beams of energetic electrons, an important consideration for choosing the site of the EIC is the planned upgrade to the Relativistic Heavy Ion Collider (RHIC) at Brookhaven National Laboratory. The upgrade planned for RHIC will fully meet the requirements for the ion beam for the EIC, providing a distinct advantage in terms of cost, schedule and the final operation.

  9. Probing TeV scale top-philic resonances with boosted top-tagging at the high luminosity LHC

    DOE PAGES

    Kim, Jeong Han; Kong, Kyoungchul; Lee, Seung J.; ...

    2016-08-24

    Here, we investigate the discovery potential of singly produced top-philic resonances at the high luminosity (HL) LHC in the four-top final state. Our analysis spans over the fully-hadronic, semi-leptonic, and same-sign dilepton channels where we present concrete search strategies adequate to a boosted kinematic regime and high jet-multiplicity environments. We utilize the Template Overlap Method (TOM) with newly developed template observables for tagging boosted top quarks, a large-radius jet variablemore » $$M_J$$ and customized b-tagging tactics for background discrimination. Our results show that the same-sign dilepton channel gives the best sensitivity among the considered channels, with an improvement of significance up to 10%-20% when combined with boosted-top tagging. Both the fully-hadronic and semi-leptonic channels yield comparable discovery potential and contribute to further enhancements in the sensitivity by combining all channels. Finally, we show the sensitivity of a top-philic resonance at the LHC and HL-LHC by showing the $$2\\sigma$$ exclusion limit and $$5\\sigma$$ discovery reach, including a combination of all three channels.« less

  10. Probing TeV scale top-philic resonances with boosted top-tagging at the high luminosity LHC

    SciTech Connect

    Kim, Jeong Han; Kong, Kyoungchul; Lee, Seung J.; Mohlabeng, Gopolang

    2016-08-24

    Here, we investigate the discovery potential of singly produced top-philic resonances at the high luminosity (HL) LHC in the four-top final state. Our analysis spans over the fully-hadronic, semi-leptonic, and same-sign dilepton channels where we present concrete search strategies adequate to a boosted kinematic regime and high jet-multiplicity environments. We utilize the Template Overlap Method (TOM) with newly developed template observables for tagging boosted top quarks, a large-radius jet variable $M_J$ and customized b-tagging tactics for background discrimination. Our results show that the same-sign dilepton channel gives the best sensitivity among the considered channels, with an improvement of significance up to 10%-20% when combined with boosted-top tagging. Both the fully-hadronic and semi-leptonic channels yield comparable discovery potential and contribute to further enhancements in the sensitivity by combining all channels. Finally, we show the sensitivity of a top-philic resonance at the LHC and HL-LHC by showing the $2\\sigma$ exclusion limit and $5\\sigma$ discovery reach, including a combination of all three channels.

  11. Common envelope mechanisms: constraints from the X-ray luminosity function of high-mass X-ray binaries

    SciTech Connect

    Zuo, Zhao-Yu; Li, Xiang-Dong E-mail: lixd@nju.edu.cn

    2014-12-10

    We use the measured X-ray luminosity function (XLF) of high-mass X-ray binaries (HMXBs) in nearby star-forming galaxies to constrain the common envelope (CE) mechanisms, which play a key role in governing the binary evolution. We find that the XLF can be reproduced quite closely under both CE mechanisms usually adopted, i.e., the α{sub CE} formalism and the γ algorithm, with a reasonable range of parameters considered. Provided that the parameter combination is the same, the γ algorithm is likely to produce more HMXBs than the α{sub CE} formalism, by a factor of up to ∼10. In the framework of the α{sub CE} formalism, a high value of α{sub CE} is required to fit the observed XLF, though it does not significantly affect the global number of the HMXB populations. We present the detailed components of the HMXB populations under the γ algorithm and compare them with those in Zuo et al. and observations. We suggest the distinct observational properties, as well as period distributions of HMXBs, may provide further clues to discriminate between these two types of CE mechanisms.

  12. MID-INFRARED DETERMINATION OF TOTAL INFRARED LUMINOSITY AND STAR FORMATION RATES OF LOCAL AND HIGH-REDSHIFT GALAXIES

    SciTech Connect

    Rujopakarn, W.; Rieke, G. H.; Weiner, B. J.; Perez-Gonzalez, P.; Rex, M.; Walth, G. L.; Kartaltepe, J. S.

    2013-04-10

    We demonstrate estimating the total infrared luminosity, L(TIR), and star formation rates (SFRs) of star-forming galaxies at redshift 0 < z < 2.8 from single-band 24 {mu}m observations, using local spectral energy distribution (SED) templates without introducing additional free parameters. Our method is based on characterizing the SEDs of galaxies as a function of their L(TIR) surface density, which is motivated by the indications that the majority of IR luminous star-forming galaxies at 1 < z < 3 have extended star-forming regions, in contrast to the strongly nuclear concentrated, merger-induced starbursts in local luminous and ultraluminous IR galaxies. We validate our procedure for estimating L(TIR) by comparing the resulting L(TIR) with those measured from far-IR observations, such as those from Herschel in the Extended Chandra Deep Field South (ECDFS) and Hubble Deep Field North (HDFN), as well as L(TIR) measured from stacked far-IR observations at redshift 0 < z < 2.8. Active galactic nuclei were excluded using X-ray and 3.6-8.0 {mu}m observations, which are generally available in deep cosmological survey fields. The Gaussian fits to the distribution of the discrepancies between the L(TIR) measurements from single-band 24 {mu}m and Herschel observations in the ECDFS and HDFN samples have {sigma} < 0.1 dex, with {approx}10% of objects disagreeing by more than 0.2 dex. Since the 24 {mu}m estimates are based on SEDs for extended galaxies, this agreement suggests that {approx}90% of IR galaxies at high z are indeed much more physically extended than local counterparts of similar L(TIR), consistent with recent independent studies of the fractions of galaxies forming stars in the main-sequence and starburst modes, respectively. Because we have not introduced empirical corrections to enhance these estimates, in principle, our method should be applicable to lower luminosity galaxies. This will enable use of the 21 {mu}m band of the Mid-Infrared Instrument on board

  13. A Rotational and Axial Motion System Load Frame Insert for In Situ High Energy X-Ray Studies (Postprint)

    DTIC Science & Technology

    2015-09-08

    AFRL-RX-WP-JA-2016-0273 A ROTATIONAL AND AXIAL MOTION SYSTEM LOAD FRAME INSERT FOR IN SITU HIGH ENERGY X - RAY STUDIES (POSTPRINT...SUBTITLE A ROTATIONAL AND AXIAL MOTION SYSTEM LOAD FRAME INSERT FOR IN SITU HIGH ENERGY X - RAY STUDIES (POSTPRINT) 5a. CONTRACT NUMBER FA8650-14...final publication is available at http://dx.doi.org/10.1063/1.4927855 14. ABSTRACT (Maximum 200 words) High energy x - ray characterization methods hold

  14. High-energy cosmic-ray nuclei from high- and low-luminosity gamma-ray bursts and implications for multimessenger astronomy

    SciTech Connect

    Murase, Kohta; Nagataki, Shigehiro; Ioka, Kunihito; Nakamura, Takashi

    2008-07-15

    Gamma-ray bursts (GRBs) are one of the candidates of ultrahigh-energy (> or approx. 10{sup 18.5} eV) cosmic-ray (UHECR) sources. We investigate high-energy cosmic-ray acceleration including heavy nuclei in GRBs by using Geant 4, and discuss its various implications, taking both high-luminosity (HL) and low-luminosity (LL) GRBs into account. This is because LL GRBs may also make a significant contribution to the observed UHECR flux if they form a distinct population. We show that not only protons, but also heavier nuclei can be accelerated up to ultrahigh energies in the internal, (external) reverse, and forward shock models. We also show that the condition for ultrahigh-energy heavy nuclei such as iron to survive is almost the same as that for {approx}TeV gamma rays to escape from the source and for high-energy neutrinos not to be much produced. The multimessenger astronomy by neutrino and GeV-TeV gamma-ray telescopes such as IceCube and KM3Net, GLAST and MAGIC will be important to see whether GRBs can be accelerators of ultrahigh-energy heavy nuclei. We also demonstrate expected spectra of high-energy neutrinos and gamma rays, and discuss their detectabilities. In addition, we discuss implications of the GRB-UHECR hypothesis. We point out, since the number densities of HL GRBs and LL GRBs are quite different, its determination by UHECR observations is also important.

  15. Effect of Wedge Insertion Angle on Posterior Tibial Slope in Medial Opening Wedge High Tibial Osteotomy

    PubMed Central

    Ogawa, Hiroyasu; Matsumoto, Kazu; Ogawa, Takahiro; Takeuchi, Kentaro; Akiyama, Haruhiko

    2016-01-01

    Background: Medial opening wedge high tibial osteotomy (HTO) is a well-established surgery for medial compartment knee osteoarthritis (OA) wherein the lower extremity is realigned to shift the load distribution from the medial compartment of the knee to the lateral compartment. However, this surgery is known to affect the posterior tibial slope angle (PTSA), which could lead to abnormal knee kinematics and instability, and eventually to knee OA. Although PTSA control is as important as coronal realignment, few appropriate measurements for this parameter have been reported. The placement of a wedge spacer might have an effect on PTSA. Purpose: To elucidate the relationship between the PTSA and the direction of insertion of a wedge spacer. Study Design: Case series; Level of evidence, 4. Methods: This study assessed 43 knees from 34 patients who underwent medial opening wedge HTO for knee OA. Pre- and postoperative lateral radiographs of the knee as well as postoperative computed tomography scans were performed to evaluate the relationship among PTSA, wedge insertion angle (WIA), and opening gap ratio (distance of the anterior opening gap/distance of the posterior opening gap at the osteotomy site). Results: The PTSA significantly increased from 9.0° ± 2.8° preoperatively to 13.2° ± 4.1° postoperatively (P < .001), resulting in a mean ΔPTSA of 4.7° ± 4.5°. The mean opening gap ratio was 0.86 ± 0.11, and the mean WIA was 25.9° ± 8.4°. The WIA and opening gap ratio were both highly correlated with ΔPTSA (r = 0.71 and 0.72, respectively), implying that a smaller WIA or smaller gap ratio leads to less increase in posterior slope. Conclusion: The direction of wedge insertion is highly correlated with PTSA increase, which suggests that the PTSA can be controlled for by adjusting the direction of wedge insertion during surgery. Clinical Relevance: Study results suggest that it is possible to adjust the PTSA by controlling the WIA during surgery. Proper

  16. Spectroscopic observations of active solar-analog stars with high X-ray luminosity, as a proxy of superflare stars

    NASA Astrophysics Data System (ADS)

    Notsu, Yuta; Honda, Satoshi; Maehara, Hiroyuki; Notsu, Shota; Namekata, Kosuke; Nogami, Daisaku; Shibata, Kazunari

    2017-02-01

    Recent studies of solar-type superflare stars have suggested that even old slowly rotating stars similar to the Sun can have large starspots and superflares. We conducted high-dispersion spectroscopy of 49 nearby solar-analog stars (G-type main-sequence stars with Teff ≈ 5600-6000 K) identified as ROSAT soft X-ray sources, which are not binary stars from previous studies. We expected that these stars could be used as a proxy of bright solar-analog superflare stars, since superflare stars are expected to show strong X-ray luminosity. More than half (37) of the 49 target stars show no evidence of binarity, and their atmospheric parameters (temperature, surface gravity, and metallicity) are within the range of ordinary solar-analog stars. We measured the intensity of Ca II 8542 and Hα lines, which are good indicators of the stellar chromospheric activity. The intensity of these lines indicates that all the target stars have large starspots. We also measured v sin i (projected rotational velocity) and lithium abundance for the target stars. Li abundance is a key to understanding the evolution of the stellar convection zone, which reflects the stellar age, mass and rotational history. We confirmed that many of the target stars rapidly rotate and have high Li abundance, compared with the Sun, as suggested by many previous studies. There are, however, also some target stars that rotate slowly (v sin i = 2-3 km s-1) and have low Li abundance like the Sun. These results support that old and slowly rotating stars similar to the Sun could have high activity levels and large starspots. This is consistent with the results of our previous studies of solar-type superflare stars. In the future, it is important to conduct long-term monitoring observations of these active solar-analog stars in order to investigate detailed properties of large starspots from the viewpoint of stellar dynamo theory.

  17. Designing high performance metal-mMoS2 interfaces by two-dimensional insertions with suitable thickness.

    PubMed

    Su, Jie; Feng, Liping; Zeng, Wei; Liu, Zhengtang

    2016-11-16

    Thickness has been proved to have significant influence on the physical properties of two-dimensional (2D) materials and their corresponding devices. Understanding the effect of the thickness of 2D insertions on the contact properties of metal-monolayer MoS2 interfaces (viz. metal-mMoS2 interfaces) is vital to designing high performance mMoS2 devices. In this work, the electronic structures, Schottky barriers, contact resistance, and tunneling barriers of scandium-mMoS2 (Sc-mMoS2) interfaces with BN and graphene insertions have been comparatively studied by density functional theory. No Schottky barriers are found at Sc-mMoS2 interfaces with monolayer 2D insertions. Although the contact resistance and charge injection efficiency of Sc-mMoS2 interfaces with monolayer insertions deteriorate relatively to those of the Sc-mMoS2 interface, they are still sufficient to realize high-performance mMoS2-based devices. Note that, upon increasing the number of layers of 2D insertions, these contact properties are further deteriorated with the increasing number of layers of insertions. Moreover, additional significant Schottky barriers are introduced into Sc-mMoS2 interfaces with multilayer BN; the nature Dirac points of graphene insertions are opened, suggesting low performances of Sc-mMoS2 interfaces with multilayer BN and graphene insertions. These variations can be understood on the basis of the orbital hybridization and charge redistribution between the Sc slab and mMoS2 layer. In addition, these characteristics are expected to occur in other metal-mMoS2 interfaces with two-dimensional material insertions. Overall, monolayer rather than multilayer two-dimensional insertions can be used to improve the transport properties of mMoS2-based devices.

  18. Large enhancement of perpendicular magnetic anisotropy and high annealing stability by Pt insertion layer in (Co/Ni)-based multilayers

    NASA Astrophysics Data System (ADS)

    Chen, Xi; Li, Minghua; Yang, Kang; Jiang, Shaolong; Han, Gang; Liu, Qianqian; Yu, Guanghua

    2015-09-01

    We have investigated the influence of ultrathin Pt insertion layers on the perpendicular magnetic anisotropy (PMA) and annealing stability of Ta/Pt/(Co/Ni)×3/Co/Pt/Ta multilayered films. When the Pt layers were inserted at the Co/Ni interfaces, the PMA of the multilayered films decreased monotonically as the thickness of the Pt insertion layer (tPt) was increased. However, when the Pt layers were inserted at the Ni/Co interfaces, the PMA increased from 1.39 × 106 to 3.5 × 106 erg/cm3 as tPt increased from 0 to 10 Å. Moreover, the multilayered film containing 6-Å-thick Pt insertion layers that inserted at the Ni/Co interfaces exhibited the highest annealing stability for PMA, which was up to temperature of 480 °C. We hypothesize that the introduced Pt/Co interfaces, due to the Pt insertion layers, are responsible for the enhanced PMA and high annealing stability. This study is particularly important for perpendicularly magnetized spintronic devices that require high PMA and high annealing stability.

  19. Dry Sliding Wear Behaviours of Valve Seat Inserts Produced from High Chromium White Iron

    NASA Astrophysics Data System (ADS)

    Kalyon, Ali; Özyürek, Dursun; Günay, Mustafa; Aztekin, Hasan

    2015-11-01

    In this present study, wear behaviours of high chromium white iron valve seat inserts and tappets used in the automotive sector were investigated. Wear behaviours of three different rates of high chromium white cast irons (containing 10, 12 and 14% chromium) were examined under heavy service conditions. For that purpose, the produced valve seat inserts were characterized through Scanning Electron Microscopy (SEM), Energy Dispersive Spectroscopy (EDS), X-ray diffraction (XRD) and hardness measurements. They were tested at a sliding speed of 1 ms-1, under 120 N load and for six different sliding distances (500, 1000, 1500, 2000, 2500, 3000 m) by using a standard wear apparatus (pin-on-disk type). The result showed that as the amount of Cr increased in the alloys, their hardness decreased. The decrease in the hardness were considered to be as the result of transformation of M7C3 carbides into M23C6 carbides in the structure. This decrease in hardness with increasing chromium content also increased the weight loss. Thus, it was determined that the white iron with 14% Cr (which had a greater amount of M23C6 carbides) was subjected to the highest wear.

  20. The Local [CII] Emission Line Luminosity Function

    NASA Astrophysics Data System (ADS)

    Hemmati, Shoubaneh

    2017-01-01

    I present, for the first time, the local [CII]158 $\\mu$m emission line luminosity function measured using a sample of more than 500 galaxies from the RBGS. [CII] luminosities are measured from the Herschel PACS observations of the LIRGs in the GOALS survey and estimated for the rest of the sample based on the far-IR luminosity and color. The sample covers 91.3% of the sky and is complete at $S_{60\\mu m} > 5.24 Jy$. We calculated the completeness as a function of [CII] line luminosity and distance, based on the far-IR color and flux densities. The [CII] luminosity function is constrained in the range $\\sim 10^{7-9} \\ L_{\\odot}$ from both the 1/Vmax and the STY maximum likelihood methods. The shape of our derived [CII] emission line luminosity function agrees well with the IR luminosity function. For the CO(1-0) and [CII] luminosity functions to agree, we propose a varying ratio of [CII]/CO(1-0) as a function of CO luminosity, with larger ratios for fainter CO luminosities. Limited [CII] high redshift observations as well as estimates based on the IR and UV luminosity functions, are suggestive of an evolution in the [CII] luminosity function similar to the evolution trend of the cosmic star formation rate density. ALMA with full capability will be able to confirm this prediction.

  1. An audit of the complications of intercostal chest drain insertion in a high volume trauma service in South Africa

    PubMed Central

    Oosthuizen, GV; Sartorius, B; Keene, C; Clarke, DL

    2014-01-01

    Introduction Intercostal chest drain (ICD) insertion is a commonly performed procedure in trauma and may be associated with significant morbidity. Methods This was a retrospective review of ICD complications in a major trauma service in South Africa over a four-year period from January 2010 to December 2013. Results A total of 1,050 ICDs were inserted in 1,006 patients, of which 91% were male. The median patient age was 24 years (interquartile range [IQR]: 20–29 years). There were 962 patients with unilateral ICDs and 44 with bilateral ICDs. Seventy-five per cent (758/1,006) sustained penetrating trauma and the remaining 25% (248/1006) sustained blunt trauma. Indications for ICD insertion were: haemopneumothorax (n=338), haemothorax (n=314), simple pneumothorax (n=265), tension pneumothorax (n=79) and open pneumothorax (n=54). Overall, 203 ICDs (19%) were associated with complications: 18% (36/203) were kinked, 18% (36/203) were inserted subcutaneously, 13% (27/203) were too shallow and in 7% (14/203) there was inadequate fixation resulting in dislodgement. Four patients (2%) sustained visceral injuries and two sustained vascular injuries. Forty-one per cent (83/203) were inserted outside the ‘triangle of safety’ but without visceral or vascular injuries. One patient had the ICD inserted on the wrong side. Junior doctors inserted 798 ICDs (76%) while senior doctors inserted 252 (24%). Junior doctors had a significantly higher complication rate (24%) compared with senior doctors (5%) (p<0.001). There was no mortality as a direct result of ICD insertion. Conclusions ICD insertion is associated with a high rate of complications. These complications are significantly higher when junior doctors perform the procedure. A multifaceted quality improvement programme is needed to improve the situation. PMID:25350185

  2. Luminosity monitor at PEP

    SciTech Connect

    Fox, J.D.; Franklin, M.E.B.

    1981-02-01

    The luminosity monitor system utilized by the MKII Detector and by the PEP operators is described. This system processes information from 56 photomultipliers and calculates independent luminosities for each of the 3 colliding bunches in PEP. Design considerations, measurement techniques, and sources of error in the luminosity measurement are discussed.

  3. Compensation of the long-range beam-beam interactions as a path towards new configurations for the high luminosity LHC

    NASA Astrophysics Data System (ADS)

    Fartoukh, Stéphane; Valishev, Alexander; Papaphilippou, Yannis; Shatilov, Dmitry

    2015-12-01

    Colliding bunch trains in a circular collider demands a certain crossing angle in order to separate the two beams transversely after the collision. The magnitude of this crossing angle is a complicated function of the bunch charge, the number of long-range beam-beam interactions, of β* and type of optics (flat or round), and possible compensation or additive effects between several low-β insertions in the ring depending on the orientation of the crossing plane at each interaction point. About 15 years ago, the use of current bearing wires was proposed at CERN in order to mitigate the long-range beam-beam effects [J. P. Koutchouk, CERN Report No. LHC-Project-Note 223, 2000], therefore offering the possibility to minimize the crossing angle with all the beneficial effects this might have: on the luminosity performance by reducing the need for crab-cavities or lowering their voltage, on the required aperture of the final focus magnets, on the strength of the orbit corrector involved in the crossing bumps, and finally on the heat load and radiation dose deposited in the final focus quadrupoles. In this paper, a semianalytical approach is developed for the compensation of the long-range beam-beam interactions with current wires. This reveals the possibility of achieving optimal correction through a careful adjustment of the aspect ratio of the β functions at the wire position. We consider the baseline luminosity upgrade plan of the Large Hadron Collider (HL-LHC project), and compare it to alternative scenarios, or so-called "configurations," where modifications are applied to optics, crossing angle, or orientation of the crossing plane in the two low-β insertions of the ring. For all these configurations, the beneficial impact of beam-beam compensation devices is then demonstrated on the tune footprint, the dynamical aperture, and/or the frequency map analysis of the nonlinear beam dynamics as the main figures of merit.

  4. Progress on the Development of the Nb3Sn 11T Dipole for the High Luminosity Upgrade of LHC

    DOE PAGES

    Savary, Frederic; Bajko, Marta; Bordini, Bernardo; ...

    2017-02-08

    The high-luminosity large hadron collider (LHC) project at CERN entered into the production phase in October 2015 after the completion of the design study phase. In the meantime, the development of the 11 T dipole needed for the upgrade of the collimation system of the machine made significant progress with very good performance of the first two-in-one magnet model of 2-m length made at CERN. The 11 T dipole, which is more powerful than the current main dipoles of LHC, can be made shorter with an equivalent integrated field. This will allow creating space for the installation of additional collimatorsmore » in specific locations of the dispersion suppressor regions. Following tests carried out during heavy ions runs of LHC in the end of 2015, and a more recent review of the project budget, the installation plan for the 11 T dipole was revised. Consequently, one 11 T dipole full assembly containing two 11 T dipoles of 5.5-m length will be installed on either side of interaction point 7. These two units shall be installed during the long shutdown 2 in years 2019-2020. After a brief reminder on the design features of the magnet, this paper describes the current status of the development activities, in particular the short model programme and the construction of the first full scale prototype at CERN. Finally, critical operations such as the reaction treatment and the coil impregnation are discussed, the quench performance tests results of the two-in-one model are reviewed and finally, the plan toward the production for the long shut down 2 is described.« less

  5. Very high-z low luminosity dusty galaxy candidates in the LABOCA follow up of the Herschel Lensing Survey

    NASA Astrophysics Data System (ADS)

    Boone, Frederic; Schaerer, Daniel; Lutz, Dieter; Weiss, Axel; Richard, Johan; Clement, Benjamin; Rawle, Tim; Egami, Eiichi; Dessauges-Zavadsky, Miroslava; Combes, Francoise; Kneib, Jean-Paul; Smail, Ian; Pello, Roser; HLS Team

    2015-08-01

    To unveil the yet hidden part of dusty star formation in the distant Universe, we have undertaken a 870μm follow-up of ten massive lensing clusters of the Herschel Lensing Survey (HLS, Egami et al 2010, Rawle et al 2010) with the APEX/LABOCA bolometer array in a large program of ˜300 hours.In four clusters (AS1063, A2744, MS2137 and A2667) we find LABOCA sources that are undetected with Herschel (PACS and SPIRE) and have S850μm /S500μm > 0.5. This very red color implies either a very high redshift (z > 4) or a very low dust temperature (T < 25K). These sources have observed fluxes S850μm < 10 mJy, and are therefore expected to have lower intrinsic luminosities than the flux-selected SMGs (H-ATLAS and SPT samples) or than blank field SMGs (e.g., LESS sample). Some of them are extended and could correspond to multiple sources or to multiple images of a lensed source.Thus, we found a very red submm source in AS1063 that may be associated with a multiple-image system confirmed spectroscopically at z=6.107. This may be the first dusty star forming galaxy with LFIR < 10^12 Lsol at z>5 selected from submm observations. Similarly, we identified potential z>4 counterparts to all the other very red LABOCA sources. We discuss the implications of these discoveries and the ongoing ALMA Cycle 2 observations.

  6. Seamless Insert-Plasmid Assembly at High Efficiency and Low Cost.

    PubMed

    Benoit, Roger M; Ostermeier, Christian; Geiser, Martin; Li, Julia Su Zhou; Widmer, Hans; Auer, Manfred

    2016-01-01

    Seamless cloning methods, such as co-transformation cloning, sequence- and ligation-independent cloning (SLIC) or the Gibson assembly, are essential tools for the precise construction of plasmids. The efficiency of co-transformation cloning is however low and the Gibson assembly reagents are expensive. With the aim to improve the robustness of seamless cloning experiments while keeping costs low, we examined the importance of complementary single-stranded DNA ends for co-transformation cloning and the influence of single-stranded gaps in circular plasmids on SLIC cloning efficiency. Most importantly, our data show that single-stranded gaps in double-stranded plasmids, which occur in typical SLIC protocols, can drastically decrease the efficiency at which the DNA transforms competent E. coli bacteria. Accordingly, filling-in of single-stranded gaps using DNA polymerase resulted in increased transformation efficiency. Ligation of the remaining nicks did not lead to a further increase in transformation efficiency. These findings demonstrate that highly efficient insert-plasmid assembly can be achieved by using only T5 exonuclease and Phusion DNA polymerase, without Taq DNA ligase from the original Gibson protocol, which significantly reduces the cost of the reactions. We successfully used this modified Gibson assembly protocol with two short insert-plasmid overlap regions, each counting only 15 nucleotides.

  7. Variables associated with peripherally inserted central catheter related infection in high risk newborn infants 1

    PubMed Central

    Rangel, Uesliz Vianna; Gomes, Saint Clair dos Santos; Costa, Ana Maria Aranha Magalhães; Moreira, Maria Elisabeth Lopes

    2014-01-01

    OBJECTIVE: to relate the variables from a surveillance form for intravenous devices in high risk newborn infants with peripherally inserted central catheter related infection. METHODOLOGY: approximately 15 variables were studied, being associated with peripherally inserted central catheter related infection, this being defined by blood culture results. The variables analyzed were obtained from the surveillance forms used with intravenous devices, attached to the medical records of newborn infants weighing between 500 and 1,499 g. The statistical association was defined using the Chi-squared and Student t tests. The study was approved by the Research Ethics Committee of the Instituto Fernandes Figueira under process N. 140.703/12. RESULTS: 63 medical records were analyzed. The infection rate observed was 25.4%. Of the variables analyzed, only three had a statistically-significant relationship with the blood culture - the use of drugs capable of inhibiting acid secretion, post-natal steroid use, and undertaking more than one invasive procedure (p-value of 0.0141, 0.0472 and 0.0277, respectively). CONCLUSION: the absence of significance of the variables of the form may be related to the quality of the records and to the absence of standardization. It is recommended that the teams be encouraged to adhere to the protocol and fill out the form. PMID:25493681

  8. Higher order mode filter design for double quarter wave crab cavity for the LHC high luminosity upgrade

    SciTech Connect

    Xiao, B.; Belomestnykh, S.; Ben-Zvi, I.; Burt, G.; Calaga, R.; Capatina, O.; Hall, B.; Jones, T.; Skaritka, J.; Verdu-Andres, S.; Wu, Q.

    2015-05-03

    A Double Quarter Wave Crab Cavity (DQWCC) was designed for the Large Hadron Collider (LHC) luminosity upgrade. A compact Higher Order Mode (HOM) filter with wide stop band at the deflecting mode is developed for this cavity. Multiphysics finite element simulation results are presented. The integration of this design to the cavity cryomodule is described.

  9. High-frequency transposition of IS1373, the insertion sequence delimiting the amplifiable element AUD2 of Streptomyces lividans.

    PubMed Central

    Volff, J N; Altenbuchner, J

    1997-01-01

    IS1373 is the putative insertion sequence delimiting the amplifiable unit AUD2 of Streptomyces lividans. Two IS1373-derived thiostrepton-resistant transposons, Tn5492 and Tn5494, transposed into multiple sites of the S. lividans chromosome at frequencies as high as 0.4 and 1%, respectively. Hence, IS1373 is a functional insertion sequence and its unique open reading frame, insA, encodes the transposase. PMID:9287031

  10. Experimental study on a Nb3Al insert coil under high magnetic field

    NASA Astrophysics Data System (ADS)

    Zhu, Guang; Dai, Yinming; Cheng, Junsheng; Chang, Kun; Liu, Jianhua; Wang, Qiuliang; Pan, Xifeng; Li, Chao

    2016-06-01

    Nb3Al is one of the most promising superconductors to replace Nb3Sn in large scale, high field superconducting magnet. Since the complicated conductor manufacturing process, long and stable Nb3Al conductor is difficult to acquire in a commercial scale. Based on a 70 m length of Nb-Al precursor conductor, we designed and fabricated a Nb3Al coil. The coil winding, low temperature diffusion heat treatment and epoxy impregnation are described in detail. The finished Nb3Al coil is tested as an insert in a background magnet. The test is performed at the background field from 7 T to 15 T. The test results are analyzed and presented in this paper.

  11. The Suzaku view of highly ionized outflows in AGN - II. Location, energetics and scalings with bolometric luminosity

    NASA Astrophysics Data System (ADS)

    Gofford, J.; Reeves, J. N.; McLaughlin, D. E.; Braito, V.; Turner, T. J.; Tombesi, F.; Cappi, M.

    2015-08-01

    Ongoing studies with XMM-Newton have shown that powerful accretion disc winds, as revealed through highly ionized Fe K-shell absorption at E ≥ 6.7 keV, are present in a significant fraction of active galactic nuclei (AGNs) in the local Universe (Tombesi et al. 2010a). In Gofford et al., we analysed a sample of 51 Suzaku-observed AGNs and independently detected Fe K absorption in ˜40 per cent of the sample, and we measured the properties of the absorbing gas. In this work, we build upon these results to consider the properties of the associated wind. On average, the fast winds (vw > 0.01c) are located ˜ 1015-18 cm (typically ˜102-4 rs) from their black hole, their mass outflow rates are of the order of < dot{M}_w > ˜ 0.01-1 M⊙ yr-1 or {˜ }(0.01-1)dot{M}_Edd and kinetic power is constrained to ˜ 1043-45 erg s-1, equivalent to ˜(0.1-10 per cent)LEdd. We find a fundamental correlation between the source bolometric luminosity and the wind velocity, with v_w ∝ L_bol^{α } and α =0.4^{+0.3}_{-0.2} (90 per cent confidence), which indicates that more luminous AGN tend to harbour faster Fe K winds. The mass outflow rate dot{M}_w, kinetic power Lw and momentum flux dot{p}_w of the winds are also consequently correlated with Lbol, such that more massive and more energetic winds are present in more luminous AGN. We investigate these properties in the framework of a continuum-driven wind, showing that the observed relationships are broadly consistent with a wind being accelerated by continuum-scattering. We find that, globally, a significant fraction (˜85 per cent) of the sample can plausibly exceed the Lw/Lbol ˜ 0.5 per cent threshold thought necessary for feedback, while 45 per cent may also exceed the less conservative ˜5 per cent of Lbol threshold as well. This suggests that the winds may be energetically significant for AGN-host-galaxy feedback processes.

  12. Supercritical Water Mixture (SCWM) Experiment in the High Temperature Insert-Reflight (HTI-R)

    NASA Technical Reports Server (NTRS)

    Hicks, Michael C.; Hegde, Uday G.; Garrabos, Yves; Lecoutre, Carole; Zappoli, Bernard

    2013-01-01

    Current research on supercritical water processes on board the International Space Station (ISS) focuses on salt precipitation and transport in a test cell designed for supercritical water. This study, known as the Supercritical Water Mixture Experiment (SCWM) serves as a precursor experiment for developing a better understanding of inorganic salt precipitation and transport during supercritical water oxidation (SCWO) processes for the eventual application of this technology for waste management and resource reclamation in microgravity conditions. During typical SCWO reactions any inorganic salts present in the reactant stream will precipitate and begin to coat reactor surfaces and control mechanisms (e.g., valves) often severely impacting the systems performance. The SCWM experiment employs a Sample Cell Unit (SCU) filled with an aqueous solution of Na2SO4 0.5-w at the critical density and uses a refurbished High Temperature Insert, which was used in an earlier ISS experiment designed to study pure water at near-critical conditions. The insert, designated as the HTI-Reflight (HTI-R) will be deployed in the DECLIC (Device for the Study of Critical Liquids and Crystallization) Facility on the International Space Station (ISS). Objectives of the study include measurement of the shift in critical temperature due to the presence of the inorganic salt, assessment of the predominant mode of precipitation (i.e., heterogeneously on SCU surfaces or homogeneously in the bulk fluid), determination of the salt morphology including size and shapes of particulate clusters, and the determination of the dominant mode of transport of salt particles in the presence of an imposed temperature gradient. Initial results from the ISS experiments will be presented and compared to findings from laboratory experiments on the ground.

  13. A Mixture Evolution Scenario of the AGN Radio Luminosity Function. II. Do Low- and High-power Radio-loud AGNs Evolve Differently?

    NASA Astrophysics Data System (ADS)

    Yuan, Zunli; Wang, Jiancheng; Zhou, Ming; Qin, Longhua; Mao, Jirong

    2017-09-01

    Following previous work, we further confirm that the cosmic evolution of steep-spectrum radio-loud AGNs (active galactic nuclei) can be reproduced by a simple combination of density evolution (DE) and luminosity evolution (LE). This mixture evolution scenario can naturally explain the luminosity-dependent evolution of radio-loud AGNs. Our models successfully fitted a large amount of data on radio luminosity functions of steep-spectrum sources and multi-frequency source counts. The modeling indicates that the DE slowly increases as {(1+z)}0.3∼ 1.3 out to z∼ 0.8, and then rapidly decreases as {(1+z)}-6.8∼ -5.7, while the LE rapidly increases as {(1+z)}4.8 out to a higher redshift (at least z> 3.5). We find a high-redshift decline (i.e., redshift cutoff) in the number density of steep-spectrum radio sources, but we cannot conclude whether such a decline is sharp or shallow. We believe that whether a redshift cutoff occurs or not depends mainly on DE, while its steepness is decided by LE, which, however, cannot be well constrained due to the lack of high-redshift samples. Most intriguingly, according to our mixture evolution scenario, there appears to be no need for different evolution for the low- and high-power radio-loud AGNs. Both types of sources experience the same combined evolution of DE and LE.

  14. Highly stable charge generation layers using caesium phosphate as n-dopants and inserting interlayers

    NASA Astrophysics Data System (ADS)

    Diez, Carola; Reusch, Thilo C. G.; Lang, Erwin; Dobbertin, Thomas; Brütting, Wolfgang

    2012-05-01

    Highly stable and efficient charge generation layers (CGLs) comprising caesium phosphate (Cs3PO4) doped 2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline (BCP) as n-type organic semiconductor and molybdenum trioxide (MoO3) doped N,N'-di-(naphthalen-1-yl)-N,N'-diphenyl-benzidine (α-NPD) as p-type organic semiconductor, respectively, are presented. By inserting narrow-gap organic copper-phthalocyanine (CuPc) and wide-gap insulating aluminum oxide (Al2O3) as interlayer (IL), we show that the long-term stability of the CGL can be improved. The variation of the CuPc IL thickness yields an optimum of 8 nm as a trade-off between minimal operating voltage and maximum voltage stability of the CGL. Luminance-current density-voltage characteristics and lifetime measurements of stacked green organic light emitting diodes (OLEDs) confirm the functionality and high voltage stability of the presented CGL. The luminous efficacy of the stacked OLED compared to the non-stacked reference device is nearly unchanged. However, the lifetime of the stacked device is enhanced by a factor of 3.5. Consistent with our experimental findings, we propose a model of the energy-level diagram of a fully doped CGL with IL based on a field-assisted tunneling mechanism.

  15. HIGH-ORDER MODELING OF AN ERL FOR ELECTRON COOLING IN THE RHIC LUMINOSITY UPGRADE USING MARYLIE/IMPACT.

    SciTech Connect

    RANJBAR,V.; BEN-ZVI,I.; PAUL, K.; ABELL, D.T.; TECH-X CORP.; KEWISCH, J.; RYNE, R.D.; QIANG, J.

    2007-06-25

    Plans for the RHIC luminosity upgrade call for an electron cooling system that will place substantial demands on the energy, current, brightness, and beam quality of the electron beam. In particular, the requirements demand a new level of fidelity in beam dynamics simulations. New developments in MARYLIE/IMPACT have improved both the space charge computations for beams with large aspect ratios and the beam dynamic computations for rf cavities. We present the results of beam dynamics simulations that include the effects of space charge and nonlinearities, and aim to assess the tolerance for errors and nonlinearities on current designs for a super-conducting ERL.

  16. Characterizing luminosity evolution in the Tevatron

    SciTech Connect

    Shiltsev, V.; McCrory, E.; /Fermilab

    2005-05-01

    We derive an approximate form of a luminosity evolution in a high intensity hadron collider taking into account the most important phenomena of intrabeam scattering (IBS), beam burn-up due to luminosity and beam-beam effects. It is well known that an exponential decay does not describe luminosity evolution very well unless the lifetime is allowed to vary with time. However, a ''1/time'' evolution, which this derivation shows is a good approximation, fits data from the Tevatron well.

  17. B_c Meson Production Around the Z^0 Peak at a High Luminosity e^+ e^- Collider

    SciTech Connect

    Yang, Zhi; Wu, Xing-Gang; Chen, Gu; Liao, Qi-Li; Zhang, Jia-Wei; /Chongqing U.

    2012-05-22

    Considering the possibility to build an e{sup +}e{sup -} collider at the energies around the Z{sup 0}-boson resonance with a planned luminosity so high as L {proportional_to} 10{sup 34} {approx} 10{sup 36} cm{sup -2}s{sup -1} (super Z-factory), we make a detailed discussion on the (c{bar b})-quarkonium production through e{sup +}e{sup -} {yields} (c{bar b})[n] + b + {bar c} within the framework of non-relativistic QCD. Here [n] stands for the Fock-states |(c{sub b}){sub 1}[{sup 1}S{sub 0}]>, |(c{bar b})8[{sup 1}S{sub 0}]g>, |(c{bar b} ){sub 1}[{sup 3}S{sub 1}]>, |(c{bar b}){sub 8}[{sup 3}S{sub 1}]g>, |(c{bar b}){sub 1}[{sup 1}P{sub 1}]> and |(c{bar b}){sub 1}[{sup 3}P{sub J}]> (with J = (1, 2, 3)) respectively. To simplify the hard-scattering amplitude as much as possible and to derive analytic expressions for the purpose of future events simulation, we adopt the 'improved trace technology' to do our calculation, which deals with the hard scattering amplitude directly at the amplitude level other than the conventional way at the squared-amplitude level. Total cross-section uncertainties caused by the quark masses are predicted by taking m{sub c} = 1.50 {+-} 0.30 GeV and m{sub b} = 4.90 {+-} 0.40 GeV. If all higher (c{bar b})-quarkonium states decay to the ground state B{sub c} (|(c{bar b}){sub 1}[{sup 1}S{sub 0}]>) with 100% efficiency, we obtain {sigma}{sub e{sup +}+e{sup -}{yields}B{sub c}+b+{bar c}} = 5.190{sub -2.419}{sup +6.222} pb, which shows that about 10{sup 5} {approx} 10{sup 7} B{sub c} events per operation year can be accumulated in the super Z-factory. If taking the collider energy runs slightly off the Z{sup 0}-peak, i.e. {radical}S = (1.00 {+-} 0.05)m{sub Z}, the total cross-section shall be lowered by about one-order from its peak value. Such a super Z-factory shall provide another useful platform to study the properties of B{sub c} meson, or even the properties of its excited P-wave states, in addition to its production at the hadronic colliders

  18. Chromaticity and low-β insertions in particle colliders

    NASA Astrophysics Data System (ADS)

    Autin, Bruno

    1990-12-01

    Besides its energy range, the main characteristic of a particle collider is its luminosity. A very important piece of equipment to achieve high luminosities is a low-β insertion, a device which focuses the beam down to a tiny spot size. The focusing limits are not only technological, they are also associated with the aberrations of such systems. This paper deals with the chromatic aberrations. In a first part, the treatment of the focusing errors is reviewed and a formalism using symbolic computation is set up so that high-order perturbations can be evaluated, although results are limited to the second-order betatron tune shift and to its interpretation. In a second part, a completely analytical theory of the final doublet of a low-β insertion is given for a special model of flat-beam focusing.

  19. Compensation of the long-range beam-beam interactions as a path towards new configurations for the high luminosity LHC

    DOE PAGES

    Fartoukh, Stéphane; Valishev, Alexander; Papaphilippou, Yannis; ...

    2015-12-01

    Colliding bunch trains in a circular collider demands a certain crossing angle in order to separate the two beams transversely after the collision. The magnitude of this crossing angle is a complicated function of the bunch charge, the number of long-range beam-beam interactions, of β* and type of optics (flat or round), and possible compensation or additive effects between several low-β insertions in the ring depending on the orientation of the crossing plane at each interaction point. About 15 years ago, the use of current bearing wires was proposed at CERN in order to mitigate the long-range beam-beam effects [J.P. Koutchouk,more » CERN Report No. LHC-Project-Note 223, 2000], therefore offering the possibility to minimize the crossing angle with all the beneficial effects this might have: on the luminosity performance by reducing the need for crab-cavities or lowering their voltage, on the required aperture of the final focus magnets, on the strength of the orbit corrector involved in the crossing bumps, and finally on the heat load and radiation dose deposited in the final focus quadrupoles. In this paper, a semianalytical approach is developed for the compensation of the long-range beam-beam interactions with current wires. This reveals the possibility of achieving optimal correction through a careful adjustment of the aspect ratio of the β functions at the wire position. We consider the baseline luminosity upgrade plan of the Large Hadron Collider (HL-LHC project), and compare it to alternative scenarios, or so-called ''configurations,'' where modifications are applied to optics, crossing angle, or orientation of the crossing plane in the two low-β insertions of the ring. Furthermore, for all these configurations, the beneficial impact of beam-beam compensation devices is then demonstrated on the tune footprint, the dynamical aperture, and/or the frequency map analysis of the nonlinear beam dynamics as the main figures of merit.« less

  20. Localising rectus muscle insertions using high frequency wide-field ultrasound biomicroscopy.

    PubMed

    Khan, Hayat Ahmad; Smith, David R; Kraft, Stephen P

    2012-05-01

    The ultrasound biomicroscope (UBM) can accurately locate an extraocular muscle (EOM) insertion. The authors compared the accuracy of the Sonomed UBM (SUBM), a new 'wide-field ultrasound biomicroscope', with the older model Humphrey UBM (HUBM) in localising EOM insertions and compared their ranges of detection of muscle insertions. Prospective, double-masked, observational study of 27 patients undergoing primary (n=40 muscles) or repeat (n=10 muscles) horizontal or vertical rectus muscle surgery. EOM insertional distances were measured with SUBM, and then intraoperatively with callipers. A Bland-Altman analysis and intraclass correlation coefficient were used to compare the SUBM and surgical data. For all muscles, the differences between SUBM and surgery measurements were less than 1.0 mm. The mean of the SUBM insertion distances was 6.67 mm (SD 1.65 mm) versus 6.7 mm (SD 1.6 mm) at surgery. The intraclass correlation coefficient showed 'excellent' correlation between the two sets of data and was higher than that reported with HUBM. The image quality with the SUBM was superior to the HUBM, and its range of field was much larger (14×18 mm vs 5×6 mm). The SUBM with its smaller, more manoeuvrable probe handpiece and a wider scanning field was more accurate in detecting muscle insertions compared with HUBM.

  1. STELLAR VELOCITY DISPERSION MEASUREMENTS IN HIGH-LUMINOSITY QUASAR HOSTS AND IMPLICATIONS FOR THE AGN BLACK HOLE MASS SCALE

    SciTech Connect

    Grier, C. J.; Martini, P.; Peterson, B. M.; Pogge, R. W.; Zu, Y.; Watson, L. C.; Bentz, M. C.; Dasyra, K. M.; Dietrich, M.; Ferrarese, L.

    2013-08-20

    We present new stellar velocity dispersion measurements for four luminous quasars with the Near-Infrared Integral Field Spectrometer instrument and the ALTAIR laser guide star adaptive optics system on the Gemini North 8 m telescope. Stellar velocity dispersion measurements and measurements of the supermassive black hole (BH) masses in luminous quasars are necessary to investigate the coevolution of BHs and galaxies, trace the details of accretion, and probe the nature of feedback. We find that higher-luminosity quasars with higher-mass BHs are not offset with respect to the M{sub BH}-{sigma}{sub *} relation exhibited by lower-luminosity active galactic nuclei (AGNs) with lower-mass BHs, nor do we see correlations with galaxy morphology. As part of this analysis, we have recalculated the virial products for the entire sample of reverberation-mapped AGNs and used these data to redetermine the mean virial factor (f) that places the reverberation data on the quiescent M{sub BH}-{sigma}{sub *} relation. With our updated measurements and new additions to the AGN sample, we obtain (f) = 4.31 {+-} 1.05, which is slightly lower than, but consistent with, most previous determinations.

  2. The High-Luminosity upgrade of the LHC: Physics and Technology Challenges for the Accelerator and the Experiments

    NASA Astrophysics Data System (ADS)

    Schmidt, Burkhard

    2016-04-01

    In the second phase of the LHC physics program, the accelerator will provide an additional integrated luminosity of about 2500/fb over 10 years of operation to the general purpose detectors ATLAS and CMS. This will substantially enlarge the mass reach in the search for new particles and will also greatly extend the potential to study the properties of the Higgs boson discovered at the LHC in 2012. In order to meet the experimental challenges of unprecedented pp luminosity, the experiments will need to address the aging of the present detectors and to improve the ability to isolate and precisely measure the products of the most interesting collisions. The lectures gave an overview of the physics motivation and described the conceptual designs and the expected performance of the upgrades of the four major experiments, ALICE, ATLAS, CMS and LHCb, along with the plans to develop the appropriate experimental techniques and a brief overview of the accelerator upgrade. Only some key points of the upgrade program of the four major experiments are discussed in this report; more information can be found in the references given at the end.

  3. Testing Design and Response of Multi-anode Photo-multiplier Tubes in High-rate Environments for Use in Future High-luminosity Experiments

    NASA Astrophysics Data System (ADS)

    Paolone, Michael; Meziani, Zein-Eddine; Joosten, Sylvester; Rehfuss, Melanie; Duran, Burcu

    2016-09-01

    As future experiments are designed on the edge of the high luminosity frontier, such as the proposed experiments for the SoLID detector at Jefferson Lab or the EIC, development of stable and efficient detectors capable of handling a high rate environment is crucial to their success. Multi-anode photo-multiplier tubes (MaPMTs), as a newer technology that is sensitive to the spatial distribution of intensity across its surface, are replacing traditional tube PMTs in many proposed experimental devices. In comparison to standard quartz-glass PMTs, MaPMT's are more cost effective, can be tiled to cover a detection plane more uniformly, and can be coated with wavelength shifting p-Terphenyl to provide similar detection efficiency in the UV spectrum. We have designed a prototype Cherenkov to test the capabilities of Hamamatsu 12700C MaPMTs in high rate conditions. Specifics of the Cherenkov detector and electronics design, as well as the response of the MaPMTs, will be presented. This work is supported through DOE Grant DE-FG02-94ER4084.

  4. Magnetic Measurements of the First Nb3Sn Model Quadrupole (MQXFS) for the High-Luminosity LHC

    SciTech Connect

    DiMarco, J.; Ambrosio, G.; Chlachidze, G.; Ferracin, P.; Holik, E.; Sabbi, G.; Stoynev, S.; Strauss, T.; Sylvester, C.; Tartaglia, M.; Todesco, E.; Velev, G.; Wang, X.

    2016-12-12

    The US LHC Accelerator Research Program (LARP) and CERN are developing high-gradient Nb3Sn magnets for the High Luminosity LHC interaction regions. Magnetic measurements of the first 1.5 m long, 150 mm aperture model quadrupole, MQXFS1, were performed during magnet assembly at LBNL, as well as during cryogenic testing at Fermilab’s Vertical Magnet Test Facility. This paper reports on the results of these magnetic characterization measurements, as well as on the performance of new probes developed for the tests.

  5. Optimizing integrated luminosity of future hadron colliders

    NASA Astrophysics Data System (ADS)

    Benedikt, Michael; Schulte, Daniel; Zimmermann, Frank

    2015-10-01

    The integrated luminosity, a key figure of merit for any particle-physics collider, is closely linked to the peak luminosity and to the beam lifetime. The instantaneous peak luminosity of a collider is constrained by a number of boundary conditions, such as the available beam current, the maximum beam-beam tune shift with acceptable beam stability and reasonable luminosity lifetime (i.e., the empirical "beam-beam limit"), or the event pileup in the physics detectors. The beam lifetime at high-luminosity hadron colliders is largely determined by particle burn off in the collisions. In future highest-energy circular colliders synchrotron radiation provides a natural damping mechanism, which can be exploited for maximizing the integrated luminosity. In this article, we derive analytical expressions describing the optimized integrated luminosity, the corresponding optimum store length, and the time evolution of relevant beam parameters, without or with radiation damping, while respecting a fixed maximum value for the total beam-beam tune shift or for the event pileup in the detector. Our results are illustrated by examples for the proton-proton luminosity of the existing Large Hadron Collider (LHC) at its design parameters, of the High-Luminosity Large Hadron Collider (HL-LHC), and of the Future Circular Collider (FCC-hh).

  6. Mapping IS6110 in high-copy number Mycobacterium tuberculosis strains shows specific insertion points in the Beijing genotype

    PubMed Central

    2013-01-01

    Background Mycobacterium tuberculosis Beijing strains are characterized by a large number of IS6110 copies, suggesting the potential implication of this element in the virulence and capacity for rapid dissemination characteristic of this family. This work studies the insetion points of IS6110 in high-copy clinical isolates specifically focusing on the Beijing genotype. Results In the present work we mapped the insertion points of IS6110 in all the Beijing strains available in the literature and in the DNA sequence databases. We generated a representative primer collection of the IS6110 locations, which was used to analyse 61 high-copy clinical isolates. A total of 440 points of insertion were identified and analysis of their flanking regions determined the exact location, the direct repeats (DRs), the orientation and the distance to neighboring genes of each copy of IS6110. We identified specific points of insertion in Beijing strains that enabled us to obtain a dendrogram that groups the Beijing genotype. Conclusions This work presents a detailed analysis of locations of IS6110 in high-copy clinical isolates, showing points of insertion present with high frequency in the Beijing family and absent in other strains. PMID:23800083

  7. Efficient screening of long terminal repeat retrotransposons that show high insertion polymorphism via high-throughput sequencing of the primer binding site.

    PubMed

    Monden, Yuki; Fujii, Nobuyuki; Yamaguchi, Kentaro; Ikeo, Kazuho; Nakazawa, Yoshiko; Waki, Takamitsu; Hirashima, Keita; Uchimura, Yosuke; Tahara, Makoto

    2014-05-01

    Retrotransposons have been used frequently for the development of molecular markers by using their insertion polymorphisms among cultivars, because multiple copies of these elements are dispersed throughout the genome and inserted copies are inherited genetically. Although a large number of long terminal repeat (LTR) retrotransposon families exist in the higher eukaryotic genomes, the identification of families that show high insertion polymorphism has been challenging. Here, we performed an efficient screening of these retrotransposon families using an Illumina HiSeq2000 sequencing platform with comprehensive LTR library construction based on the primer binding site (PBS), which is located adjacent to the 5' LTR and has a motif that is universal and conserved among LTR retrotransposon families. The paired-end sequencing library of the fragments containing a large number of LTR sequences and their insertion sites was sequenced for seven strawberry (Fragaria × ananassa Duchesne) cultivars and one diploid wild species (Fragaria vesca L.). Among them, we screened 24 families with a "unique" insertion site that appeared only in one cultivar and not in any others, assuming that this type of insertion should have occurred quite recently. Finally, we confirmed experimentally the selected LTR families showed high insertion polymorphisms among closely related cultivars.

  8. Quantitative insertion-site sequencing (QIseq) for high throughput phenotyping of transposon mutants.

    PubMed

    Bronner, Iraad F; Otto, Thomas D; Zhang, Min; Udenze, Kenneth; Wang, Chengqi; Quail, Michael A; Jiang, Rays H Y; Adams, John H; Rayner, Julian C

    2016-07-01

    Genetic screening using random transposon insertions has been a powerful tool for uncovering biology in prokaryotes, where whole-genome saturating screens have been performed in multiple organisms. In eukaryotes, such screens have proven more problematic, in part because of the lack of a sensitive and robust system for identifying transposon insertion sites. We here describe quantitative insertion-site sequencing, or QIseq, which uses custom library preparation and Illumina sequencing technology and is able to identify insertion sites from both the 5' and 3' ends of the transposon, providing an inbuilt level of validation. The approach was developed using piggyBac mutants in the human malaria parasite Plasmodium falciparum but should be applicable to many other eukaryotic genomes. QIseq proved accurate, confirming known sites in >100 mutants, and sensitive, identifying and monitoring sites over a >10,000-fold dynamic range of sequence counts. Applying QIseq to uncloned parasites shortly after transfections revealed multiple insertions in mixed populations and suggests that >4000 independent mutants could be generated from relatively modest scales of transfection, providing a clear pathway to genome-scale screens in P. falciparum QIseq was also used to monitor the growth of pools of previously cloned mutants and reproducibly differentiated between deleterious and neutral mutations in competitive growth. Among the mutants with fitness defects was a mutant with a piggyBac insertion immediately upstream of the kelch protein K13 gene associated with artemisinin resistance, implying mutants in this gene may have competitive fitness costs. QIseq has the potential to enable the scale-up of piggyBac-mediated genetics across multiple eukaryotic systems.

  9. Generation of highly N-type, defect passivated transition metal oxides using plasma fluorine insertion

    DOEpatents

    Baker, L. Robert; Seo, Hyungtak; Hervier, Antoine; Somorjai, Gabor A.

    2016-04-12

    A new composition of matter is disclosed wherein oxygen vacancies in a semiconducting transition metal oxide such as titanium dioxide are filled with a halogen such as Fluorine, whereby the conductivity of the composition is greatly enhanced, while at the same time the chemical stability of the composition is greatly improved. Stoichiometric titanium dioxide having less than 3 % oxygen vacancies is subject to fluorine insertion such that oxygen vacancies are filled, limited amounts of fluorine replace additional oxygen atoms and fluorine interstitially inserts into the body of the TiO.sub.2 composition.

  10. High risk of deep vein thrombosis associated with peripherally inserted central catheters in lymphoma

    PubMed Central

    Li, Chao-Feng; Wang, Yu; Liu, Pan-Pan; Bi, Xi-Wen; Sun, Peng; Lin, Tong-Yu; Jiang, Wen-Qi; Li, Zhi-Ming

    2016-01-01

    Peripherally inserted central venous catheters (PICCs) are widely used in cancer patients. Although PICC is a convenient tool, its use is associated with an obvious increase in the incidence of venous thrombosis. The risk factors for deep vein thrombosis associated with the use of PICCs in cancer patients are largely unexplored. This study aimed to investigate the incidence of PICC-associated thrombosis in lymphoma compared with its incidences in other types of cancer. A total of 8028 adult cancer patients inserted with PICC between June 2007 and June 2015 were included in this study. A total of 249 of the 8028 included patients (3.1%) inserted with PICC developed upper extremity deep vein thrombosis (PICC-UEDVT). Patients with lymphoma were more likely to have PICC-UEDVT than those with other types of malignancies (7.1% vs. 2.80%; P < 0.001). Logistic analysis revealed that a lymphoma diagnosis was a risk factor for UEDVT in cancer patients inserted with PICC (OR: 3.849, 95% CI: 2.334–6.347). Patients with lymphoma may be more predisposed to developing PICC-UEDVT than those with other types of malignancies. Identifying the mechanism underlying the relationship between PICC-UEDVT and lymphoma requires further study. PMID:27078849

  11. A novel adaptive needle insertion sequencing for robotic, single needle MR-guided high-dose-rate prostate brachytherapy

    NASA Astrophysics Data System (ADS)

    Borot de Battisti, M.; de Senneville, B. Denis; Hautvast, G.; Binnekamp, D.; Lagendijk, J. J. W.; Maenhout, M.; Moerland, M. A.

    2017-05-01

    MR-guided high-dose-rate (HDR) brachytherapy has gained increasing interest as a treatment for patients with localized prostate cancer because of the superior value of MRI for tumor and surrounding tissues localization. To enable needle insertion into the prostate with the patient in the MR bore, a single needle MR-compatible robotic system involving needle-by-needle dose delivery has been developed at our institution. Throughout the intervention, dose delivery may be impaired by: (1) sub-optimal needle positioning caused by e.g. needle bending, (2) intra-operative internal organ motion such as prostate rotations or swelling, or intra-procedural rectum or bladder filling. This may result in failure to reach clinical constraints. To assess the first aforementioned challenge, a recent study from our research group demonstrated that the deposited dose may be greatly improved by real-time adaptive planning with feedback on the actual needle positioning. However, the needle insertion sequence is left to the doctor and therefore, this may result in sub-optimal dose delivery. In this manuscript, a new method is proposed to determine and update automatically the needle insertion sequence. This strategy is based on the determination of the most sensitive needle track. The sensitivity of a needle track is defined as its impact on the dose distribution in case of sub-optimal positioning. A stochastic criterion is thus presented to determine each needle track sensitivity based on needle insertion simulations. To assess the proposed sequencing strategy, HDR prostate brachytherapy was simulated on 11 patients with varying number of needle insertions. Sub-optimal needle positioning was simulated at each insertion (modeled by typical random angulation errors). In 91% of the scenarios, the dose distribution improved when the needle was inserted into the most compared to the least sensitive needle track. The computation time for sequencing was less than 6 s per needle track. The

  12. The Intermediate Luminosity Optical Transient SN 2010da: The Progenitor, Eruption and Aftermath of an Unusual Supergiant High-mass X-ray Binary

    NASA Astrophysics Data System (ADS)

    Villar, Victoria; Berger, Edo; Chornock, Ryan; Laskar, Tanmoy; Margutti, Raffaella; Brown, Peter J.

    2016-06-01

    We present high- and medium-resolution optical spectroscopy, optical/UV imaging and archival Chandra, Hubble and Spitzer observations of the intermediate luminosity optical transient (ILOT) SN 2010da, discovered in the nearby galaxy NGC 300 (d=1.86 Mpc). SN 2010da had a peak absolute magnitude of M ~ -10.4 mag, dimmer than other recent ILOTs and supernova impostors. We detect hydrogen Balmer, Paschen and Ca II emission lines in our high-resolution spectra, which indicate a dusty and complex circumstellar environment. Based on SN 2010da's light curve and multi-epoch SEDs, we conclude that the progenitor of SN 2010da is a ~10-12 Msol yellow supergiant possibly transitioning into a blue loop phase. Since the 2010 eruption, the star has brightened by a factor of ~5 and remains highly variable in the optical. SN 2010da is a unique ILOT which seems to stem from a different physical origin than red SN 2008S-like events and luminous blue variable outbursts. Furthermore, we detect SN 2010da in archival Swift observations as an ultraluminous X-ray source. We additionally attribute He II 4686 and coronal Fe emission in addition to a steady X-ray luminosity of ~10^{37} erg/s to the presence of a compact companion.

  13. Subaru High-z Exploration of Low-luminosity Quasars (SHELLQs). I. Discovery of 15 Quasars and Bright Galaxies at 5.7 < z < 6.9

    NASA Astrophysics Data System (ADS)

    Matsuoka, Yoshiki; Onoue, Masafusa; Kashikawa, Nobunari; Iwasawa, Kazushi; Strauss, Michael A.; Nagao, Tohru; Imanishi, Masatoshi; Niida, Mana; Toba, Yoshiki; Akiyama, Masayuki; Asami, Naoko; Bosch, James; Foucaud, Sébastien; Furusawa, Hisanori; Goto, Tomotsugu; Gunn, James E.; Harikane, Yuichi; Ikeda, Hiroyuki; Kawaguchi, Toshihiro; Kikuta, Satoshi; Komiyama, Yutaka; Lupton, Robert H.; Minezaki, Takeo; Miyazaki, Satoshi; Morokuma, Tomoki; Murayama, Hitoshi; Nishizawa, Atsushi J.; Ono, Yoshiaki; Ouchi, Masami; Price, Paul A.; Sameshima, Hiroaki; Silverman, John D.; Sugiyama, Naoshi; Tait, Philip J.; Takada, Masahiro; Takata, Tadafumi; Tanaka, Masayuki; Tang, Ji-Jia; Utsumi, Yousuke

    2016-09-01

    We report the discovery of 15 quasars and bright galaxies at 5.7 < z < 6.9. This is the initial result from the Subaru High-z Exploration of Low-Luminosity Quasars project, which exploits the exquisite multiband imaging data produced by the Subaru Hyper Suprime-Cam (HSC) Strategic Program survey. The candidate selection is performed by combining several photometric approaches including a Bayesian probabilistic algorithm to reject stars and dwarfs. The spectroscopic identification was carried out with the Gran Telescopio Canarias and the Subaru Telescope for the first 80 deg2 of the survey footprint. The success rate of our photometric selection is quite high, approaching 100% at the brighter magnitudes (z AB < 23.5 mag). Our selection also recovered all the known high-z quasars on the HSC images. Among the 15 discovered objects, six are likely quasars, while the other six with interstellar absorption lines and in some cases narrow emission lines are likely bright Lyman-break galaxies. The remaining three objects have weak continua and very strong and narrow Lyα lines, which may be excited by ultraviolet light from both young stars and quasars. These results indicate that we are starting to see the steep rise of the luminosity function of z ≥ 6 galaxies, compared with that of quasars, at magnitudes fainter than M 1450 ˜ -22 mag or z AB ˜ 24 mag. Follow-up studies of the discovered objects as well as further survey observations are ongoing.

  14. Hiding from the moonlight: luminosity and temperature affect activity of Asian nocturnal primates in a highly seasonal forest.

    PubMed

    Starr, Carly; Nekaris, K A I; Leung, Luke

    2012-01-01

    The effect of moonlight and temperature on activity of slow lorises was previously little known and this knowledge might be useful for understanding many aspects of their behavioural ecology, and developing strategies to monitor and protect populations. In this study we aimed to determine if the activity of the pygmy loris (Nycticebus pygmaeus) is affected by ambient temperature and/or moonlight in a mixed deciduous forest. We radio-collared five females and five males in the Seima Protection Forest, Cambodia, in February to May, 2008 and January to March, 2009 and recorded their behaviour at 5 minutes intervals, totalling 2736 observations. We classified each observation as either inactive (sleeping or alert) or active behaviour (travel, feeding, grooming, or others). Moon luminosity (bright/dark) and ambient temperature were recorded for each observation. The response variable, activity, was binary (active or inactive), and a logit link function was used. Ambient temperature alone did not significantly affect mean activity. Although mean activity was significantly affected by moonlight, the interaction between moonlight and temperature was also significant: on bright nights, studied animals were increasingly more active with higher temperature; and on dark nights they were consistently active regardless of temperature. The most plausible explanation is that on bright cold nights the combined risk of being seen and attacked by predators and heat loss outweigh the benefit of active behaviours.

  15. Second-generation coil design of the Nb3Sn low-β quadrupole for the high luminosity LHC

    DOE PAGES

    Bermudez, S. Izquierdo; Ambrosio, G.; Ballarino, A.; ...

    2016-01-18

    As part of the Large Hadron Collider Luminosity upgrade (HiLumi-LHC) program, the US LARP collaboration and CERN are working together to design and build a 150 mm aperture Nb3Sn quadrupole for the LHC interaction regions. A first series of 1.5 m long coils were fabricated and assembled in a first short model. A detailed visual inspection of the coils was carried out to investigate cable dimensional changes during heat treatment and the position of the windings in the coil straight section and in the end region. The analyses allow identifying a set of design changes which, combined with a finemore » tune of the cable geometry and a field quality optimization, were implemented in a new, second-generation, coil design. In this study, we review the main characteristics of the first generation coils, describe the modification in coil lay-out, and discuss their impact on parts design and magnet analysis.« less

  16. Bright end of the luminosity function of high-mass X-ray binaries: contributions of hard, soft and supersoft sources

    NASA Astrophysics Data System (ADS)

    Sazonov, S.; Khabibullin, I.

    2017-04-01

    Using a spectral analysis of bright Chandra X-ray sources located in 27 nearby galaxies and maps of star-formation rate (SFR) and interstellar medium surface densities for these galaxies, we constructed the intrinsic X-ray luminosity function (XLF) of luminous high-mass X-ray binaries (HMXBs), taking into account absorption effects and the diversity of HMXB spectra. The XLF per unit SFR can be described by a power-law dN/dlog LX,unabs ≈ 2.0(LX,unabs/1039 erg s-1)-0.6 (M⊙ yr-1)-1 from LX,unabs = 1038 to 1040.5 erg s-1, where LX,unabs is the unabsorbed luminosity at 0.25-8 keV. The intrinsic number of luminous HMXBs per unit SFR is a factor of ∼2.3 larger than the observed number reported before. The intrinsic XLF is composed of hard, soft and supersoft sources (defined here as those with the 0.25-2 keV to 0.25-8 keV flux ratio of <0.6, 0.6-0.95 and >0.95, respectively) in ∼ 2:1:1 proportion. We also constructed the intrinsic HMXB XLF in the soft X-ray band (0.25-2 keV). Here, the numbers of hard, soft and supersoft sources prove to be nearly equal. The cumulative present-day 0.25-2 keV emissivity of HMXBs with luminosities between 1038 and 1040.5 erg s-1 is ∼5 × 1039 erg s-1(M⊙ yr-1)-1, which may be relevant for studying the X-ray preheating of the early Universe.

  17. The Intermediate Luminosity Optical Transient SN 2010da: The Progenitor, Eruption, and Aftermath of a Peculiar Supergiant High-mass X-Ray Binary

    NASA Astrophysics Data System (ADS)

    Villar, V. A.; Berger, E.; Chornock, R.; Margutti, R.; Laskar, T.; Brown, P. J.; Blanchard, P. K.; Czekala, I.; Lunnan, R.; Reynolds, M. T.

    2016-10-01

    We present optical spectroscopy, ultraviolet-to-infrared imaging, and X-ray observations of the intermediate luminosity optical transient (ILOT) SN 2010da in NGC 300 (d = 1.86 Mpc) spanning from -6 to +6 years relative to the time of outburst in 2010. Based on the light-curve and multi-epoch spectral energy distributions of SN 2010da, we conclude that the progenitor of SN 2010da is a ≈10-12 M ⊙ yellow supergiant possibly transitioning into a blue-loop phase. During outburst, SN 2010da had a peak absolute magnitude of M bol ≲ -10.4 mag, dimmer than other ILOTs and supernova impostors. We detect multi-component hydrogen Balmer, Paschen, and Ca ii emission lines in our high-resolution spectra, which indicate a dusty and complex circumstellar environment. Since the 2010 eruption, the star has brightened by a factor of ≈5 and remains highly variable in the optical. Furthermore, we detect SN 2010da in archival Swift and Chandra observations as an ultraluminous X-ray source (L X ≈ 6 × 1039 erg s-1). We additionally attribute He ii 4686 Å and coronal Fe emission lines in addition to a steady X-ray luminosity of ≈1037 erg s-1 to the presence of a compact companion.

  18. High Thermal Dissipation of Al Heat Sink When Inserting Ceramic Powders by Ultrasonic Mechanical Coating and Armoring

    PubMed Central

    Tsai, Wei-Yu; Huang, Guan-Rong; Wang, Kuang-Kuo; Chen, Chin-Fu; Huang, J. C.

    2017-01-01

    Aluminum alloys, which serve as heat sink in light-emitting diode (LED) lighting, are often inherent with a high thermal conductivity, but poor thermal total emissivity. Thus, high emissive coatings on the Al substrate can enhance the thermal dissipation efficiency of radiation. In this study, the ultrasonic mechanical coating and armoring (UMCA) technique was used to insert various ceramic combinations, such as Al2O3, SiO2, or graphite, to enhance thermal dissipation. Analytic models have been established to couple the thermal radiation and convection on the sample surface through heat flow equations. A promising match has been reached between the theoretical predictions and experimental measurements. With the adequate insertion of ceramic powders, the temperature of the Al heat sinks can be lowered by 5–11 °C, which is highly favorable for applications requiring cooling components. PMID:28772814

  19. High Thermal Dissipation of Al Heat Sink When Inserting Ceramic Powders by Ultrasonic Mechanical Coating and Armoring.

    PubMed

    Tsai, Wei-Yu; Huang, Guan-Rong; Wang, Kuang-Kuo; Chen, Chin-Fu; Huang, J C

    2017-04-26

    Aluminum alloys, which serve as heat sink in light-emitting diode (LED) lighting, are often inherent with a high thermal conductivity, but poor thermal total emissivity. Thus, high emissive coatings on the Al substrate can enhance the thermal dissipation efficiency of radiation. In this study, the ultrasonic mechanical coating and armoring (UMCA) technique was used to insert various ceramic combinations, such as Al₂O₃, SiO₂, or graphite, to enhance thermal dissipation. Analytic models have been established to couple the thermal radiation and convection on the sample surface through heat flow equations. A promising match has been reached between the theoretical predictions and experimental measurements. With the adequate insertion of ceramic powders, the temperature of the Al heat sinks can be lowered by 5-11 °C, which is highly favorable for applications requiring cooling components.

  20. STS atmospheric luminosities

    NASA Technical Reports Server (NTRS)

    Mende, S. B.

    1984-01-01

    During the STS-8 space shuttle mission special photographic and TV operations were carried out to record the properties of the spacecraft induced luminosities. One of these luminous phenomena is the quiescent vehicle glow which was photographed during the STS-8 mission with an image intensified photographic camera, with and without an objective grating. During the latter part of the mission the altitude of the shuttle was relatively low (120 n.m. = 222 km) and unprecedentedly high intensity of the glow was observed. The crew reported that the glow was easily visible to the naked eye. The proper orientation of the shuttle with respect to the velocity vector and the objective grating permitted the exposure of good objective spectrum of the glow in the visible region. From the results it is clear that the spectrum appears to be a continuum as observed by the image intensifier objective grating camera. Qualitative examination of the data shows that there is very tail little glow ion the wavelength range of 4300 to about 5000 angstroms. Above 5000 angstroms the glow becomes stronger towards the red and then it falls off towards higher wavelength and of the spectrum presumably because of the responsivity of the device.

  1. Alluaudite class of high voltage sodium insertion materials: An interplay of polymorphism and magnetism

    NASA Astrophysics Data System (ADS)

    Dwibedi, Debasmita; Barpanda, Prabeer

    2017-05-01

    The research and development with sodium ion batteries has geared up manifold in last one decade, owing to their abundance, non-toxicity, uniform geographical distribution and electrochemical performance complimentary to lithium counterpart. This research often leads to various novel material discoveries such as Na2Fe2(SO4)3 sodium insertion material, which has recently registered the highest-ever Fe3+/Fe2+ redox potential (3.8 V vs. Na) having excellent cyclability and rate kinetics. This basically belongs to a family of materials-Alluaudites Na2M2(SO4)3 (M: Fe, Mn, Co, Ni). Such cathode insertion compounds are basically functional materials, involving redox active 3d transition metals that are often magnetic in nature. We have investigated the magnetic structure and properties of - Alluaudites Na2M2(SO4)3. These alluaudite shows wide structural diversity and polymorphism. Employing various experimental methods involving diffraction, magnetic susceptibility, Mössbauer spectroscopy and low temperature neutron powder diffraction data we have explored the magnetic properties exhibited by the Alluaudite class of insertion materials.

  2. High patient satisfaction of inflatable penile prosthesis insertion with synchronous penile plication for erectile dysfunction and Peyronie's disease.

    PubMed

    Chung, Paul H; Scott, J Francis; Morey, Allen F

    2014-06-01

    Twenty to thirty percent of patients with Peyronie's disease (PD) have erectile dysfunction (ED) refractory to medical therapy and may benefit from a combined procedure addressing both conditions. The aim of this study was to show the efficacy of inflatable penile prosthesis (IPP) insertion and synchronous penile plication for correcting penile curvature and ED in patients with PD. A retrospective review was performed of all patients who underwent IPP insertion with synchronous penile plication at our tertiary care center between 2010 and 2013. All patients received an intraoperative saline intracorporal injection to induce an artificial erection. After the tunica albuginea was exposed via a standard transverse scrotal incision over the proximal penile shaft, the incision was retracted distally and/or laterally as needed for plication suture placement. Plication sutures were placed in parallel opposite the angle of greatest curvature. The incision was returned proximally to the standard penoscrotal junction for IPP insertion. Demographic and surgical data were collected from the patients' medical records. Patient satisfaction was assessed postoperatively using a nonvalidated questionnaire. The focus of this study was surgical outcomes, both technical and patient-reported satisfaction. Eighteen patients with a mean age of 63 years underwent IPP insertion with synchronous penile plication. Patients presented with dorsal (n = 11), lateral (n = 2), and biplanar curvature (n = 5). Mean preoperative curvature was 39 degrees (range 30-60) and was corrected on average to <5 degrees (range <5-12) using a median of four plication sutures (range 3-6). Among 15 patients completing a postoperative satisfaction survey at a mean of 11 months, all reported improvement in their overall condition and penile curvature; one with biplanar deformity reported minor residual curvature. None reported continued pain or required suture release. IPP insertion with synchronous

  3. The First Detection of [O IV] from an Ultraluminous X-ray Source with Spitzer. 2; Evidence for High Luminosity in Holmberg II ULX

    NASA Technical Reports Server (NTRS)

    Berghea, C. T.; Dudik, R. P.; Weaver, K. A.; Kallman, T. R.

    2009-01-01

    This is the second of two papers examining Spitzer Infrared Spectrograph (IRS) observations of the ultraluminous X-ray source (ULX) in Holmberg II. Here we perform detailed photoionization modeling of the infrared lines. Our analysis suggests that the luminosity and morphology of the [O IV] 25.89 micron emission line is consistent with photoionization by the soft X-ray and far ultraviolet (FUV) radiation from the accretion disk of the binary system and inconsistent with narrow beaming. We show that the emission nebula is matter-bounded both in the line of sight direction and to the east, and probably radiation-bounded to the west. A bolometric luminosity in excess of 10(exp 40) erg/s would be needed to produce the measured [O IV] flux. We use modeling and previously published studies to conclude that shocks likely contribute very little, if at all, to the high-excitation line fluxes observed in the Holmberg II ULX. Additionally, we find that the spectral type of the companion star has a surprisingly strong effect on the predicted strength of the [O IV] emission. This finding could explain the origin of [O IV] in some starburst systems containing black hole binaries.

  4. The First Detection of [O IV] from an Ultraluminous X-ray Source with Spitzer. II. Evidence for High Luminosity in Holmberg II ULX

    NASA Technical Reports Server (NTRS)

    Berghea, C. T.; Dudik, R. P.; Weaver, K. A.; Kallman, T. R.

    2009-01-01

    This is the second of two papers examining Spitzer Infrared Spectrograph (IRS) observations of the ultraluminous X-ray source (ULX) in Holmberg II. Here we perform detailed photoionization modeling of they infrared lines. Our analysis suggests that the luminosity and morphology of the [O IV] 25.89 micron emission line is consistent with photoionization by the soft X-ray and far ultraviolet (FUV) radiation from the accretion disk of the binary system and inconsistent with narrow beaming. We show that the emission nebula is matter-bounded both in the line of sight direction and to the east, and probably radiation-bounded to the west. A bolometric luminosity in excess of 1040 erg per second would be needed to produce the measured [O IV] flux. We use modeling and previously published studies to conclude that shacks likely contribute very little, if at all, to the high excitation line fluxes observed in the Holmberg II ULX. Additionally, we find that the spectral type of the companion star has a surprisingly strong effect on they predicted strength of the [O IV] emission. This finding could explain the origin of [O IV] hi some starburst systems containing black hole binaries.

  5. The First Detection of (O IV) from an Ultraluminous X-Ray Source with Spitzer. 2. Evidence for High Luminosity in Holmberg II ULX

    NASA Technical Reports Server (NTRS)

    Berghea, C T.; Dudik, R P.; Weaver, K A.; Kallman, T R.

    2010-01-01

    This is the second of two papers examining Spitzer Infrared Spectrograph observations of the ultraluminous X-ray source (ULX) in Holmberg II. Here, we perform detailed photoionization modeling of the infrared lines. Our analysis suggests that the luminosity and morphology of the [Oiv] 25.89 micronmeters emission line is consistent with photoionization by the soft X-ray and far ultraviolet (FUV) radiation from the accretion disk of the binary system and inconsistent with narrow beaming. We show that the emission nebula is matter bounded both in the line-of-sight direction and to the east, and probably radiation-bounded to the west. A bolometric luminosity in excess of 10(exp 40) erg s(exp -1) would be needed to produce the measured [O iv] flux. We use modeling and previously published studies to conclude that shocks likely contribute very little, if at all,to the high-ionization line fluxes observed in the Holmberg II ULX. Additionally, we find that the spectral type of the companion star has a surprisingly strong effect on the predicted strength of the [O iv] emission. This finding could explain the origin of [O iv] in some starburst systems containing black hole binaries.

  6. THE FIRST DETECTION OF [O IV] FROM AN ULTRALUMINOUS X-RAY SOURCE WITH SPITZER. II. EVIDENCE FOR HIGH LUMINOSITY IN HOLMBERG II ULX

    SciTech Connect

    Berghea, C. T.; Dudik, R. P.; Weaver, K. A.; Kallman, T. R. E-mail: ciprian.berghea.ctr@usno.navy.mi

    2010-01-01

    This is the second of two papers examining Spitzer Infrared Spectrograph observations of the ultraluminous X-ray source (ULX) in Holmberg II. Here, we perform detailed photoionization modeling of the infrared lines. Our analysis suggests that the luminosity and morphology of the [O IV] 25.89 mum emission line is consistent with photoionization by the soft X-ray and far ultraviolet (FUV) radiation from the accretion disk of the binary system and inconsistent with narrow beaming. We show that the emission nebula is matter-bounded both in the line-of-sight direction and to the east, and probably radiation-bounded to the west. A bolometric luminosity in excess of 10{sup 40} erg s{sup -1} would be needed to produce the measured [O IV] flux. We use modeling and previously published studies to conclude that shocks likely contribute very little, if at all, to the high-ionization line fluxes observed in the Holmberg II ULX. Additionally, we find that the spectral type of the companion star has a surprisingly strong effect on the predicted strength of the [O IV] emission. This finding could explain the origin of [O IV] in some starburst systems containing black hole binaries.

  7. The First Detection of (O IV) from an Ultraluminous X-Ray Source with Spitzer. 2. Evidence for High Luminosity in Holmberg II ULX

    NASA Technical Reports Server (NTRS)

    Berghea, C T.; Dudik, R P.; Weaver, K A.; Kallman, T R.

    2010-01-01

    This is the second of two papers examining Spitzer Infrared Spectrograph observations of the ultraluminous X-ray source (ULX) in Holmberg II. Here, we perform detailed photoionization modeling of the infrared lines. Our analysis suggests that the luminosity and morphology of the [Oiv] 25.89 micronmeters emission line is consistent with photoionization by the soft X-ray and far ultraviolet (FUV) radiation from the accretion disk of the binary system and inconsistent with narrow beaming. We show that the emission nebula is matter bounded both in the line-of-sight direction and to the east, and probably radiation-bounded to the west. A bolometric luminosity in excess of 10(exp 40) erg s(exp -1) would be needed to produce the measured [O iv] flux. We use modeling and previously published studies to conclude that shocks likely contribute very little, if at all,to the high-ionization line fluxes observed in the Holmberg II ULX. Additionally, we find that the spectral type of the companion star has a surprisingly strong effect on the predicted strength of the [O iv] emission. This finding could explain the origin of [O iv] in some starburst systems containing black hole binaries.

  8. Search for single production of the heavy vectorlike T quark with T →t h and h →γ γ at the high-luminosity LHC

    NASA Astrophysics Data System (ADS)

    Liu, Yao-Bei

    2017-02-01

    The vectorlike top partners T are predicted in many extensions of the Standard Model (SM). In a simplified model including a single vectorlike T quark with charge 2 /3 , we investigate the process p p →T j induced by the couplings between the top partner with the first and the third generation quarks at the LHC. We find that the mixing with the first generation can enhance the production cross section. We further study the observability of the single heavy top partner through the process p p →T (→t h )j →t (→b ℓνℓ)h (→γ γ )j at the high-luminosity (HL)-LHC (a 14 TeV p p collider with an integrated luminosity of 3 ab-1 ). For three typical heavy T quark masses mT=600 , 800 and 1000 GeV, the 3 σ exclusion limits, as well as the 5 σ discovery reach in the parameter plane of the two variables g*-RL, are respectively obtained at the HL-LHC.

  9. Estimative of conversion fractions of AGN magnetic luminosity to produce ultra high energy cosmic rays from the observation of Fermi-LAT gamma rays

    NASA Astrophysics Data System (ADS)

    Coimbra-Araújo, Carlos H.; Anjos, Rita C.

    2017-01-01

    A fraction of the magnetic luminosity (LB) produced by Kerr black holes in some active galactic nuclei (AGNs) can produce the necessary energy to accelerate ultra high energy cosmic rays (UHECRs) beyond the GZK limit, observed, e.g., by the Pierre Auger experiment. Nevertheless, the direct detection of those UHECRs has a lack of information about the direction of the source from where those cosmic rays are coming, since charged particles are deflected by the intergalactic magnetic field. This problem arises the needing of alternative methods to evaluate the luminosity of UHECRs (LCR) from a given source. Methods proposed in literature range from the observation of upper limits in gamma rays to the observation of upper limits in neutrinos produced by cascade effects during the propagation of UHECRs. In this aspect, the present work proposes a method to calculate limits of the main possible conversion fractions ηCR = LCR/LB for nine UHECR AGN Seyfert sources based on the respective observation of gamma ray upper limits from Fermi-LAT data.

  10. Mechanical studies towards a silicon micro-strip super module for the ATLAS inner detector upgrade at the high luminosity LHC

    NASA Astrophysics Data System (ADS)

    Barbier, G.; Cadoux, F.; Clark, A.; Endo, M.; Favre, Y.; Ferrere, D.; Gonzalez-Sevilla, S.; Hanagaki, K.; Hara, K.; Iacobucci, G.; Ikegami, Y.; Jinnouchi, O.; La Marra, D.; Nakamura, K.; Nishimura, R.; Perrin, E.; Seez, W.; Takubo, Y.; Takashima, R.; Terada, S.; Todome, K.; Unno, Y.; Weber, M.

    2014-04-01

    It is expected that after several years of data-taking, the Large Hadron Collider (LHC) physics programme will be extended to the so-called High-Luminosity LHC, where the instantaneous luminosity will be increased up to 5 × 1034 cm-2 s-1. For the general-purpose ATLAS experiment at the LHC, a complete replacement of its internal tracking detector will be necessary, as the existing detector will not provide the required performance due to the cumulated radiation damage and the increase in the detector occupancy. The baseline layout for the new ATLAS tracker is an all-silicon-based detector, with pixel sensors in the inner layers and silicon micro-strip detectors at intermediate and outer radii. The super-module (SM) is an integration concept proposed for the barrel strip region of the future ATLAS tracker, where double-sided stereo silicon micro-strip modules (DSM) are assembled into a low-mass local support (LS) structure. Mechanical aspects of the proposed LS structure are described.

  11. Accelerator Science: Luminosity vs. Energy

    SciTech Connect

    Lincoln, Don

    2016-09-19

    In the world of high energy physics there are several parameters that are important when one constructs a particle accelerator. Two crucial ones are the energy of the beam and the luminosity, which is another word for the number of particles in the beam. In this video, Fermilab’s Dr. Don Lincoln explains the differences and the pros and cons. He even works in an unexpected sporting event.

  12. Accelerator Science: Luminosity vs. Energy

    ScienceCinema

    Lincoln, Don

    2016-09-28

    In the world of high energy physics there are several parameters that are important when one constructs a particle accelerator. Two crucial ones are the energy of the beam and the luminosity, which is another word for the number of particles in the beam. In this video, Fermilab’s Dr. Don Lincoln explains the differences and the pros and cons. He even works in an unexpected sporting event.

  13. Globular Cluster Systems in Brightest Cluster Galaxies: Bimodal Metallicity Distributions and the Nature of the High-Luminosity Clusters

    NASA Astrophysics Data System (ADS)

    Harris, William E.; Whitmore, Bradley C.; Karakla, Diane; Okoń, Waldemar; Baum, William A.; Hanes, David A.; Kavelaars, J. J.

    2006-01-01

    We present new (B, I) photometry for the globular cluster systems in eight brightest cluster galaxies (BCGs), obtained with the ACS/WFC camera on the Hubble Space Telescope. In the very rich cluster systems that reside within these giant galaxies, we find that all have strongly bimodal color distributions that are clearly resolved by the metallicity-sensitive (B-I) index. Furthermore, the mean colors and internal color range of the blue subpopulation are remarkably similar from one galaxy to the next, to well within the +/-0.02-0.03 mag uncertainties in the foreground reddenings and photometric zero points. By contrast, the mean color and internal color range for the red subpopulation differ from one galaxy to the next by twice as much as the blue population. All the BCGs show population gradients, with much higher relative numbers of red clusters within 5 kpc of their centers, consistent with their having formed at later times than the blue, metal-poor population. A striking new feature of the color distributions emerging from our data is that for the brightest clusters (MI<-10.5) the color distribution becomes broad and less obviously bimodal. This effect was first noticed by Ostrov et al. and Dirsch et al. for the Fornax giant NGC 1399; our data suggest that it may be a characteristic of many BCGs and perhaps other large galaxies. Our data indicate that the blue (metal-poor) clusters brighter than MI~=-10 become progressively redder with increasing luminosity, following a mass/metallicity scaling relation Z~M0.55. A basically similar relation has been found for M87 by Strader et al. (2005). We argue that these GCS characteristics are consistent with a hierarchical-merging galaxy formation picture in which the metal-poor clusters formed in protogalactic clouds or dense starburst complexes with gas masses in the range 107-1010 Msolar, but where the more massive clusters on average formed in bigger clouds with deeper potential wells where more preenrichment could

  14. Herschel-ATLAS Galaxy Counts and High-redshift Luminosity Functions: The Formation of Massive Early-type Galaxies

    NASA Astrophysics Data System (ADS)

    Lapi, A.; González-Nuevo, J.; Fan, L.; Bressan, A.; De Zotti, G.; Danese, L.; Negrello, M.; Dunne, L.; Eales, S.; Maddox, S.; Auld, R.; Baes, M.; Bonfield, D. G.; Buttiglione, S.; Cava, A.; Clements, D. L.; Cooray, A.; Dariush, A.; Dye, S.; Fritz, J.; Herranz, D.; Hopwood, R.; Ibar, E.; Ivison, R.; Jarvis, M. J.; Kaviraj, S.; López-Caniego, M.; Massardi, M.; Michałowski, M. J.; Pascale, E.; Pohlen, M.; Rigby, E.; Rodighiero, G.; Serjeant, S.; Smith, D. J. B.; Temi, P.; Wardlow, J.; van der Werf, P.

    2011-11-01

    Exploiting the Herschel Astrophysical Terahertz Large Area Survey Science Demonstration Phase survey data, we have determined the luminosity functions (LFs) at rest-frame wavelengths of 100 and 250 μm and at several redshifts z >~ 1, for bright submillimeter galaxies with star formation rates (SFRs) >~ 100 M ⊙ yr-1. We find that the evolution of the comoving LF is strong up to z ≈ 2.5, and slows down at higher redshifts. From the LFs and the information on halo masses inferred from clustering analysis, we derived an average relation between SFR and halo mass (and its scatter). We also infer that the timescale of the main episode of dust-enshrouded star formation in massive halos (M H >~ 3 × 1012 M ⊙) amounts to ~7 × 108 yr. Given the SFRs, which are in the range of 102-103 M ⊙ yr-1, this timescale implies final stellar masses of the order of 1011-1012 M ⊙. The corresponding stellar mass function matches the observed mass function of passively evolving galaxies at z >~ 1. The comparison of the statistics for submillimeter and UV-selected galaxies suggests that the dust-free, UV bright phase is >~ 102 times shorter than the submillimeter bright phase, implying that the dust must form soon after the onset of star formation. Using a single reference spectral energy distribution (SED; the one of the z ≈ 2.3 galaxy SMM J2135-0102), our simple physical model is able to reproduce not only the LFs at different redshifts >1 but also the counts at wavelengths ranging from 250 μm to ≈1 mm. Owing to the steepness of the counts and their relatively broad frequency range, this result suggests that the dispersion of submillimeter SEDs of z > 1 galaxies around the reference one is rather small. Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA.

  15. (N2)6Ne7: A High Pressure van der Waals Insertion Compound

    NASA Astrophysics Data System (ADS)

    Plisson, Thomas; Weck, Gunnar; Loubeyre, Paul

    2014-07-01

    The binary phase diagram of N2-Ne mixtures has been measured at 296 K by visual observation and Raman spectroscopy. The topology of the phase diagram points to the existence of the stoichiometric compound (N2)6Ne7. Its structure has been solved by single-crystal synchrotron x-ray diffraction. The N2 molecules form a guest lattice that hosts the Ne atoms. This insertion compound can be viewed as a clathrate with the centers of the N2 molecules forming distorted dodecahedron cages, each enclosing 14 Ne atoms. Remarkably, the (N2)6Ne7 compound is somehow the first clathrate organized by the quadrupolar interaction.

  16. (N(2))(6)Ne(7): A high pressure van der Waals insertion compound.

    PubMed

    Plisson, Thomas; Weck, Gunnar; Loubeyre, Paul

    2014-07-11

    The binary phase diagram of N(2)-Ne mixtures has been measured at 296 K by visual observation and Raman spectroscopy. The topology of the phase diagram points to the existence of the stoichiometric compound N(2))(6)Ne(7). Its structure has been solved by single-crystal synchrotron x-ray diffraction. The N(2) molecules form a guest lattice that hosts the Ne atoms. This insertion compound can be viewed as a clathrate with the centers of the N(2) molecules forming distorted dodecahedron cages, each enclosing 14 Ne atoms. Remarkably, the N(2))(6)Ne(7) compound is somehow the first clathrate organized by the quadrupolar interaction.

  17. Insert Coil Test for HEP High Field Magnets Using YBCO Coated Conductor Tapes

    SciTech Connect

    Lombardo, V.; Barzi, E.; Turrioni, D.; Zlobin, A.V.; /Fermilab

    2011-06-15

    The final beam cooling stages of a Muon Collider may require DC solenoid magnets with magnetic fields of 30-50 T. In this paper we present progress in insert coil development using commercially available YBa{sub 2}Cu{sub 3}O{sub 7-{delta}} Coated Conductor. Technological aspects covered in the development, including coil geometry, insulation, manufacturing process and testing are summarized and discussed. Test results of double pancake coils operated in liquid nitrogen and liquid helium are presented and compared with the performance of YBa{sub 2}Cu{sub 3}O{sub 7-{delta}} tape short samples.

  18. High-Resolution Tracking Asymmetric Lithium Insertion and Extraction and Local Structure Ordering in SnS2.

    PubMed

    Gao, Peng; Wang, Liping; Zhang, Yu-Yang; Huang, Yuan; Liao, Lei; Sutter, Peter; Liu, Kaihui; Yu, Dapeng; Wang, En-Ge

    2016-09-14

    In the rechargeable lithium ion batteries, the rate capability and energy efficiency are largely governed by the lithium ion transport dynamics and phase transition pathways in electrodes. Real-time and atomic-scale tracking of fully reversible lithium insertion and extraction processes in electrodes, which would ultimately lead to mechanistic understanding of how the electrodes function and why they fail, is highly desirable but very challenging. Here, we track lithium insertion and extraction in the van der Waals interactions dominated SnS2 by in situ high-resolution TEM method. We find that the lithium insertion occurs via a fast two-phase reaction to form expanded and defective LiSnS2, while the lithium extraction initially involves heterogeneous nucleation of intermediate superstructure Li0.5SnS2 domains with a 1-4 nm size. Density functional theory calculations indicate that the Li0.5SnS2 is kinetically favored and structurally stable. The asymmetric reaction pathways may supply enlightening insights into the mechanistic understanding of the underlying electrochemistry in the layered electrode materials and also suggest possible alternatives to the accepted explanation of the origins of voltage hysteresis in the intercalation electrode materials.

  19. High-Resolution X-Ray Spectroscopy of a Low-Luminosity Active Galactic Nucleus: The Structure and Dynamics of M81*

    NASA Astrophysics Data System (ADS)

    Young, A. J.; Nowak, M. A.; Markoff, S.; Marshall, H. L.; Canizares, C. R.

    2007-11-01

    We present Chandra HETGS observations of the low-luminosity active galactic nucleus (LLAGN) of M81. The HETGS is unique in providing high-resolution spectroscopy of the central 1" of M81, including the iron K bandpass. The continuum is a power law of photon index Γ=1.8, similar to that seen in highly luminous AGNs. Highly ionized emission lines, characteristic of gas at temperatures of T=106-108 K, are detected. Many of these thermal lines are velocity broadened, with a FWHM of approximately 1500 km s-1. A separate thermal component is associated with a 2557 km s-1 redshifted Fe XXVI emission line, characteristic of gas at temperatures T=107.4-108 K. Neutral Fe, Ar, and Si Kα fluorescence lines indicate the presence of cold, dense material. The Si Kα fluorescence line is velocity broadened, with a FWHM of 1200 km s-1. If the fluorescence lines are produced by reflection from cold, Compton thick material, then the line strengths are not compatible with solar abundances, instead favoring enhanced Ar and Si abundances with respect to the Fe abundance. The Fe Kα line is narrow, with no evidence of a thin disk extending inside 55rg (where rg=GM/c2 is the gravitational radius for a black hole of mass M). We show that a simple spectral model used to represent the expectations from a radiatively inefficient accretion flow (RIAF) describes the X-ray data well, while in a companion paper we will show that jet models with parameters similar to fits of hard state X-ray binaries describe both the X-ray and broadband (radio/optical) spectra. The HETGS spectra we present here offer an unprecedented view of the inner workings of a low-luminosity accretion flow, and thus can quantitatively constrain theoretical accretion flow models of LLAGNs such as M81*.

  20. The search for low-luminosity high-mass X-ray binaries and the study of X-ray populations in the Galactic disk

    NASA Astrophysics Data System (ADS)

    Fornasini, Francesca; Tomsick, John; Bodaghee, Arash; Rahoui, Farid; Krivonos, Roman; Corral-Santana, Jesus; An, Hongjun; Bauer, Franz E.; Gotthelf, Eric V.; Stern, Daniel; NuSTAR Galactic Plane Survey Team

    2016-01-01

    High-mass X-ray binaries (HMXBs), which consist of a neutron star (NS) or black hole (BH) accreting material from a massive stellar companion, provide valuable insights into the evolution of massive stars and the merger rates of NS/NS, NS/BH, and BH/BH binaries whose gravitational wave signatures will soon be detectable by facilities such as Advanced-LIGO. INTEGRAL discoveries of new classes of lower-luminosity HMXBs, some highly obscured and some showing extreme transient activity, as well as the recent discovery of the very quiescent and only known Be-BH binary, have considerably changed our understanding of clumping in massive stellar winds and the relative importance of different binary evolutionary channels. In order to better characterize the low-luminosity HMXB population, we have performed a survey of a square degree region in the direction of the Norma spiral arm with Chandra and NuSTAR. These surveys, combined with optical and infrared spectroscopic follow-up of the counterparts of hard X-ray sources, have yielded three HMXB candidates to date. Future radial-velocity follow-up of these candidates, as well as other Be HMXB candidates from the NuSTAR serendipitous survey, will help determine whether these sources truly are HMXBs and, if so, constrain the mass of the compact object in these systems. If confirmed, these HMXB candidates could extend our measurement of the HMXB luminosity function by about two orders of magnitude and provide important constraints on massive binary evolutionary models. In addition, the colliding wind binaries and pulsar wind nebulae discovered in the Norma X-ray survey will help shed light on other aspects of massive stellar evolution and massive stellar remnants. Finally, these surveys provide the opportunity to compare the hard X-ray populations in the Galactic disk and the Galactic Center. While the dominant hard X-ray populations in both of these Galactic regions appear to be cataclysmic variables (CVs), those in the Norma

  1. Unusual features of negative leaders' development in natural lightning, according to simultaneous records of current, electric field, luminosity, and high-speed video

    NASA Astrophysics Data System (ADS)

    Guimaraes, Miguel; Arcanjo, Marcelo; Murta Vale, Maria Helena; Visacro, Silverio

    2017-02-01

    The development of downward and upward leaders that formed two negative cloud-to-ground return strokes in natural lightning, spaced only about 200 µs apart and terminating on ground only a few hundred meters away, was monitored at Morro do Cachimbo Station, Brazil. The simultaneous records of current, close electric field, relative luminosity, and corresponding high-speed video frames (sampling rate of 20,000 frames per second) reveal that the initiation of the first return stroke interfered in the development of the second negative leader, leading it to an apparent continuous development before the attachment, without stepping, and at a regular two-dimensional speed. Based on the experimental data, the formation processes of the two return strokes are discussed, and plausible interpretations for their development are provided.

  2. NLC Luminosity as a Function of Beam Parameters

    SciTech Connect

    Nosochkov, Yuri

    2002-06-06

    Realistic calculation of NLC luminosity has been performed using particle tracking in DIMAD and beam-beam simulations in GUINEA-PIG code for various values of beam emittance, energy and beta functions at the Interaction Point (IP). Results of the simulations are compared with analytic luminosity calculations. The optimum range of IP beta functions for high luminosity was identified.

  3. NLC Luminosity as a Function of Beam Parameters

    NASA Astrophysics Data System (ADS)

    Nosochkov, Y.

    2002-06-01

    Realistic calculation of NLC luminosity has been performed using particle tracking in DIMAD and beam-beam simulations in GUINEA-PIG code for various values of beam emittance, energy and beta functions at the Interaction Point (IP). Results of the simulations are compared with analytic luminosity calculations. The optimum range of IP beta functions for high luminosity was identified.

  4. Construction of a linkage map based on retrotransposon insertion polymorphisms in sweetpotato via high-throughput sequencing.

    PubMed

    Monden, Yuki; Hara, Takuya; Okada, Yoshihiro; Jahana, Osamu; Kobayashi, Akira; Tabuchi, Hiroaki; Onaga, Shoko; Tahara, Makoto

    2015-03-01

    Sweetpotato (Ipomoea batatas L.) is an outcrossing hexaploid species with a large number of chromosomes (2n = 6x = 90). Although sweetpotato is one of the world's most important crops, genetic analysis of the species has been hindered by its genetic complexity combined with the lack of a whole genome sequence. In the present study, we constructed a genetic linkage map based on retrotransposon insertion polymorphisms using a mapping population derived from a cross between 'Purple Sweet Lord' (PSL) and '90IDN-47' cultivars. High-throughput sequencing and subsequent data analyses identified many Rtsp-1 retrotransposon insertion sites, and their allele dosages (simplex, duplex, triplex, or double-simplex) were determined based on segregation ratios in the mapping population. Using a pseudo-testcross strategy, 43 and 47 linkage groups were generated for PSL and 90IDN-47, respectively. Interestingly, most of these insertions (~90%) were present in a simplex manner, indicating their utility for linkage map construction in polyploid species. Additionally, our approach led to savings of time and labor for genotyping. Although the number of markers herein was insufficient for map-based cloning, our trial analysis exhibited the utility of retrotransposon-based markers for linkage map construction in sweetpotato.

  5. Construction of a linkage map based on retrotransposon insertion polymorphisms in sweetpotato via high-throughput sequencing

    PubMed Central

    Monden, Yuki; Hara, Takuya; Okada, Yoshihiro; Jahana, Osamu; Kobayashi, Akira; Tabuchi, Hiroaki; Onaga, Shoko; Tahara, Makoto

    2015-01-01

    Sweetpotato (Ipomoea batatas L.) is an outcrossing hexaploid species with a large number of chromosomes (2n = 6x = 90). Although sweetpotato is one of the world’s most important crops, genetic analysis of the species has been hindered by its genetic complexity combined with the lack of a whole genome sequence. In the present study, we constructed a genetic linkage map based on retrotransposon insertion polymorphisms using a mapping population derived from a cross between ‘Purple Sweet Lord’ (PSL) and ‘90IDN-47’ cultivars. High-throughput sequencing and subsequent data analyses identified many Rtsp-1 retrotransposon insertion sites, and their allele dosages (simplex, duplex, triplex, or double-simplex) were determined based on segregation ratios in the mapping population. Using a pseudo-testcross strategy, 43 and 47 linkage groups were generated for PSL and 90IDN-47, respectively. Interestingly, most of these insertions (~90%) were present in a simplex manner, indicating their utility for linkage map construction in polyploid species. Additionally, our approach led to savings of time and labor for genotyping. Although the number of markers herein was insufficient for map-based cloning, our trial analysis exhibited the utility of retrotransposon-based markers for linkage map construction in sweetpotato. PMID:26069444

  6. MR-compatibility of a high-resolution small animal PET insert operating inside a 7 T MRI.

    PubMed

    Thiessen, J D; Shams, E; Stortz, G; Schellenberg, G; Bishop, D; Khan, M S; Kozlowski, P; Retière, F; Sossi, V; Thompson, C J; Goertzen, A L

    2016-11-21

    A full-ring PET insert consisting of 16 PET detector modules was designed and constructed to fit within the 114 mm diameter gradient bore of a Bruker 7 T MRI. The individual detector modules contain two silicon photomultiplier (SiPM) arrays, dual-layer offset LYSO crystal arrays, and high-definition multimedia interface (HDMI) cables for both signal and power transmission. Several different RF shielding configurations were assessed prior to construction of a fully assembled PET insert using a combination of carbon fibre and copper foil for RF shielding. MR-compatibility measurements included field mapping of the static magnetic field (B 0) and the time-varying excitation field (B 1) as well as acquisitions with multiple pulse sequences: spin echo (SE), rapid imaging with refocused echoes (RARE), fast low angle shot (FLASH) gradient echo, and echo planar imaging (EPI). B 0 field maps revealed a small degradation in the mean homogeneity (+0.1 ppm) when the PET insert was installed and operating. No significant change was observed in the B 1 field maps or the image homogeneity of various MR images, with a 9% decrease in the signal-to-noise ratio (SNR) observed only in EPI images acquired with the PET insert installed and operating. PET detector flood histograms, photopeak amplitudes, and energy resolutions were unchanged in individual PET detector modules when acquired during MRI operation. There was a small baseline shift on the PET detector signals due to the switching amplifiers used to power MRI gradient pulses. This baseline shift was observable when measured with an oscilloscope and varied as a function of the gradient duty cycle, but had no noticeable effect on the performance of the PET detector modules. Compact front-end electronics and effective RF shielding led to minimal cross-interference between the PET and MRI systems. Both PET detector and MRI performance was excellent, whether operating as a standalone system or a hybrid PET/MRI.

  7. MR-compatibility of a high-resolution small animal PET insert operating inside a 7 T MRI

    NASA Astrophysics Data System (ADS)

    Thiessen, J. D.; Shams, E.; Stortz, G.; Schellenberg, G.; Bishop, D.; Khan, M. S.; Kozlowski, P.; Retière, F.; Sossi, V.; Thompson, C. J.; Goertzen, A. L.

    2016-11-01

    A full-ring PET insert consisting of 16 PET detector modules was designed and constructed to fit within the 114 mm diameter gradient bore of a Bruker 7 T MRI. The individual detector modules contain two silicon photomultiplier (SiPM) arrays, dual-layer offset LYSO crystal arrays, and high-definition multimedia interface (HDMI) cables for both signal and power transmission. Several different RF shielding configurations were assessed prior to construction of a fully assembled PET insert using a combination of carbon fibre and copper foil for RF shielding. MR-compatibility measurements included field mapping of the static magnetic field (B 0) and the time-varying excitation field (B 1) as well as acquisitions with multiple pulse sequences: spin echo (SE), rapid imaging with refocused echoes (RARE), fast low angle shot (FLASH) gradient echo, and echo planar imaging (EPI). B 0 field maps revealed a small degradation in the mean homogeneity (+0.1 ppm) when the PET insert was installed and operating. No significant change was observed in the B 1 field maps or the image homogeneity of various MR images, with a 9% decrease in the signal-to-noise ratio (SNR) observed only in EPI images acquired with the PET insert installed and operating. PET detector flood histograms, photopeak amplitudes, and energy resolutions were unchanged in individual PET detector modules when acquired during MRI operation. There was a small baseline shift on the PET detector signals due to the switching amplifiers used to power MRI gradient pulses. This baseline shift was observable when measured with an oscilloscope and varied as a function of the gradient duty cycle, but had no noticeable effect on the performance of the PET detector modules. Compact front-end electronics and effective RF shielding led to minimal cross-interference between the PET and MRI systems. Both PET detector and MRI performance was excellent, whether operating as a standalone system or a hybrid PET/MRI.

  8. Feeding tube insertion - gastrostomy

    MedlinePlus

    ... tube insertion; G-tube insertion; PEG tube insertion; Stomach tube insertion; Percutaneous endoscopic gastrostomy tube insertion ... and down the esophagus, which leads to the stomach. After the endoscopy tube is inserted, the skin ...

  9. Development of an FPW Biosensor with Low Insertion Loss and High Fabrication Yield for Detection of Carcinoembryonic Antigen

    PubMed Central

    Lan, Je-Wei; Huang, I-Yu; Lin, Yu-Cheng; Lin, Chang-Yu; Chen, Jian-Lin; Hsieh, Chia-Hsu

    2016-01-01

    In the last two decades, various flexural plate-wave (FPW)-based biosensors with low phase velocity, low operation frequency, high sensitivity, and short response time, have been developed. However, conventional FPW transducers have low fabrication yield because controlling the thickness of silicon/isolation/metal/piezoelectric multilayer floating thin-plate is difficult. Additionally, conventional FPW devices usually have high insertion loss because of wave energy dissipation to the silicon substrate or outside area of the output interdigital transducers (IDTs). These two disadvantages hinder the application of FPW devices. To reduce the high insertion loss of FPW devices, we designed two focus-type IDTs (fan-shaped and circular, respectively) that can effectively confine the launched wave energy, and adopted a focus-type silicon-grooved reflective grating structure (RGS) that can reduce the wave propagation loss. To accurately control the thickness of the silicon thin-plate and substantially improve the fabrication yield of FPW transducers, a 60 °C/27 °C two-step anisotropic wet etching process was developed. Compared with conventional FPW devices (with parallel-type IDTs and without RGS), the proposed FPW devices have lower insertion loss (36.04 dB) and higher fabrication yield (63.88%). Furthermore, by using cystamine-based self-assembled monolayer (SAM) nanotechnology, we used the improved FPW device to develop a novel FPW-based carcinoembryonic antigen (CEA) biosensor for detection of colorectal cancer, and this FPW-CEA biosensor has a low detection limit (5 ng/mL), short response time (<10 min), high sensitivity (60.16–70.06 cm2/g), and high sensing linearity (R-square = 0.859–0.980). PMID:27834798

  10. COLLECTIVE PROPERTIES OF X-RAY BINARY POPULATIONS OF GALAXIES. I. LUMINOSITY AND ORBITAL PERIOD DISTRIBUTIONS OF HIGH-MASS X-RAY BINARIES

    SciTech Connect

    Bhadkamkar, Harshal; Ghosh, Pranab

    2012-02-10

    We introduce a method for obtaining the X-ray luminosity function (XLF) and the binary-period distribution of populations of high-mass X-ray binaries (HMXBs) in the stellar fields (i.e.,outside globular clusters) of normal galaxies. We start from standard distributions of the parameters of those primordial binaries which are the progenitors of HMXBs and follow the transformation of these distributions with the aid of a Jacobian formalism as the former evolve into the latter through the processes of the first mass transfer and the supernova (SN) that follows. We discuss the distributions of the post-SN binaries and the HMXBs. We show that our calculated model XLF has a differential slope Almost-Equal-To - 1.6 with a flattening at low luminosities, in excellent agreement with observations. The calculated binary-period distribution, which basically has a slightly sloping plateau-like character at intermediate periods, with a rise to this plateau at shorter periods and fall-off from it at longer periods, is in agreement with the observed distribution within observational uncertainties. We discuss the physical origin of these distributions. We demonstrate that, while the effects of both (1) the distribution of the properties of the massive companion in the HMXBs and (2) the primordial orbital distribution and the SN dynamics are important, the former appear to be dominant in determining the XLF, and the latter in determining the HMXB binary-period distribution. We discuss the possible roles of stellar-mass black holes and ultraluminous X-ray sources in the observed 'universal' XLF of HMXBs.

  11. Pinhole Luminosity Monitor with Feedback

    SciTech Connect

    Spencer, J

    2004-05-17

    Previously, the generalized luminosity L was defined and calculated for all incident channels based on an NLC e{sup +}e{sup -} design. Alternatives were then considered to improve the differing beam-beam e{sup -}e{sup -} e{gamma} and {gamma}{gamma} channels. Regardless of the channel, there was a large flux of outgoing, high energy photons that were produced from the beam-beam interaction e.g. beamsstrahlung that needs to be disposed of and whose flux depended on L. One approach to this problem is to consider it a resource and attempt to take advantage of it by disposing of these straight-ahead photons in more useful ways than simply dumping them. While there are many options for monitoring the luminosity, any method that allows feedback and optimization in real time and in a non-intercepting and non-interfering way during normal data taking is extremely important--especially if it provides other capabilities such as high resolution tuning of spot sizes and can be used for all incident channels without essential modifications to their setup. Our ''pin-hole'' camera appears to be such a device if it can be made to work with high energy photons in ways that are compatible with the many other constraints and demands on space around the interaction region. The basis for using this method is that it has, in principle, the inherent resolution and bandwidth to monitor the very small spot sizes and their stabilities that are required for very high, integrated luminosity. While there are many possible, simultaneous uses of these outgoing photon beams, we limit our discussion to a single, blind, proof-of-principle experiment that was done on the FFTB line at SLAC to certify the concept of a camera obscura for high energy photons.

  12. Metal-film subwavelength-grating polarizer with low insertion losses and high extinction ratios in the terahertz region.

    PubMed

    Shiraishi, Kazuo; Muraki, Kengo

    2015-06-29

    A metal-film subwavelength-grating polarizer with high performance in the terahertz region is presented. The polarizer was obtained by depositing a thin Au film on a resin grating with a triangular cross section duplicated from a metal mold by using the imprinting method. Microstructural parameters were investigated in detail. Measured insertion losses were less than 0.5 dB in the frequency range of 0.5-3 THz, while extinction ratios were 50 dB in the range of 0.5-2.3 THz. The proposed fabrication method is suited to mass production of large-aperture robust polarizers.

  13. A Novel Protein Domain Induces High Affinity Selenocysteine Insertion Sequence Binding and Elongation Factor Recruitment*

    PubMed Central

    Donovan, Jesse; Caban, Kelvin; Ranaweera, Ruchira; Gonzalez-Flores, Jonathan N.; Copeland, Paul R.

    2008-01-01

    Selenocysteine (Sec) is incorporated at UGA codons in mRNAs possessing a Sec insertion sequence (SECIS) element in their 3′-untranslated region. At least three additional factors are necessary for Sec incorporation: SECIS-binding protein 2 (SBP2), Sec-tRNASec, and a Sec-specific translation elongation factor (eEFSec). The C-terminal half of SBP2 is sufficient to promote Sec incorporation in vitro, which is carried out by the concerted action of a novel Sec incorporation domain and an L7Ae RNA-binding domain. Using alanine scanning mutagenesis, we show that two distinct regions of the Sec incorporation domain are required for Sec incorporation. Physical separation of the Sec incorporation and RNA-binding domains revealed that they are able to function in trans and established a novel role of the Sec incorporation domain in promoting SECIS and eEFSec binding to the SBP2 RNA-binding domain. We propose a model in which SECIS binding induces a conformational change in SBP2 that recruits eEFSec, which in concert with the Sec incorporation domain gains access to the ribosomal A site. PMID:18948268

  14. GAMA/WiggleZ: the 1.4 GHz radio luminosity functions of high- and low-excitation radio galaxies and their redshift evolution to z = 0.75

    NASA Astrophysics Data System (ADS)

    Pracy, Michael B.; Ching, John H. Y.; Sadler, Elaine M.; Croom, Scott M.; Baldry, I. K.; Bland-Hawthorn, Joss; Brough, S.; Brown, M. J. I.; Couch, Warrick J.; Davis, Tamara M.; Drinkwater, Michael J.; Hopkins, A. M.; Jarvis, M. J.; Jelliffe, Ben; Jurek, Russell J.; Loveday, J.; Pimbblet, K. A.; Prescott, M.; Wisnioski, Emily; Woods, David

    2016-07-01

    We present radio active galactic nuclei (AGN) luminosity functions over the redshift range 0.005 < z < 0.75. The sample from which the luminosity functions are constructed is an optical spectroscopic survey of radio galaxies, identified from matched Faint Images of the Radio Sky at Twenty-cm survey (FIRST) sources and Sloan Digital Sky Survey images. The radio AGN are separated into low-excitation radio galaxies (LERGs) and high-excitation radio galaxies (HERGs) using the optical spectra. We derive radio luminosity functions for LERGs and HERGs separately in the three redshift bins (0.005 < z < 0.3, 0.3 < z < 0.5 and 0.5 < z < 0.75). The radio luminosity functions can be well described by a double power law. Assuming this double power-law shape the LERG population displays little or no evolution over this redshift range evolving as {˜ } (1+z)^{0.06^{+0.17}_{-0.18}} assuming pure density evolution or {˜ } (1+z)^{0.46^{+0.22}_{-0.24}} assuming pure luminosity evolution. In contrast, the HERG population evolves more rapidly, best fitted by {˜ } (1+z)^{2.93^{+0.46}_{-0.47}} assuming a double power-law shape and pure density evolution. If a pure luminosity model is assumed, the best-fitting HERG evolution is parametrized by {˜ } (1+z)^{7.41^{+0.79}_{-1.33}}. The characteristic break in the radio luminosity function occurs at a significantly higher power (≳1 dex) for the HERG population in comparison to the LERGs. This is consistent with the two populations representing fundamentally different accretion modes.

  15. A smart strategy to fabricate Ru nanoparticle inserted porous carbon nanofibers as highly efficient levulinic acid hydrogenation catalysts

    SciTech Connect

    Yang, Ying; Sun, Cheng-Jun; Brown, Dennis E.; Zhang, Liqiang; Yang, Feng; Zhao, Hairui; Wang, Yue; Ma, Xiaohui; Zhang, Xin; Ren, Yang

    2016-01-01

    Herein, we first put forward a smart strategy to in situ fabricate Ru nanoparticle (NP) inserted porous carbon nanofibers by one-pot conversion of Ru-functionalized metal organic framework fibers. Such fiber precursors are skillfully constructed by cooperative assembly of different proportional RuCl3 and Zn(Ac)2·2H2O along with trimesic acid (H3BTC) in the presence of N,N-dimethylformamide. The following high-temperature pyrolysis affords uniform and evenly dispersed Ru NPs (ca. 12-16 nm), which are firmly inserted into the hierarchically porous carbon nanofibers formed simultaneously. The resulting Ru-carbon nanofiber (Ru-CNF) catalysts prove to be active towards the liquid-phase hydrogenation of levulinic acid (LA) to γ-valerolactone (GVL), a biomass-derived platform molecule with wide applications in the preparation of renewable chemicals and liquid transportation fuels. The optimal GVL yield of 96.0% is obtained, corresponding to a high activity of 9.23 molLAh–1gRu–1, 17 times of that using the commercial Ru/C catalyst. Moreover, the Ru-CNF catalyst is extremely stable, and can be cycled up to 7 times without significant loss of reactivity. Our strategy demonstrated here reveals new possibilities to make proficient metal catalysts, and provides a general way to fabricate metal-carbon nanofiber composites available for other applications.

  16. Detector Technologies for Sub-500um High-Sensitivity PET Imaging via a Novel PET Insert Approach

    SciTech Connect

    Tai, Yuan-Chuan

    2011-12-21

    The objective of this project was to develop detector technologies that would enable an ultrahigh resolution Virtual Pinhole (VP) PET insert device to provide sub-500 um resolution high-sensitivity PET imaging of a mouse in the future. To achieve this goal, we proposed to develop and characterize finely pixellated cadmium zinc telluride (CZT) detectors and the associated readout electronics with the following specific aims: 1. Develop pixellated CZT detectors with 350um pitches using 2-5 mm substrates; characterize their spatial, energy and timing performance through experiments; and optimize the anode design with steering grid if found necessary. 2. Develop a high-bandwidth readout system using a novel ASIC that can be directly bonded to CZT detectors with 2048 anodes of 350um pitches; optimize its overall performance for VP-PET applications considering the tradeoffs between spatial resolution (in 3D), count rate capability, timing and energy resolutions. 3. Evaluate the performance of a VP-PET insert based on the proposed detector technology through Monte Carlo simulation and experimental validation. Overall, we have completed all three specific aims and demonstrated that pixelated CZT detectors of 350um pitches, combined with VP-PET geometry, can provide PET image resolution of ~460 um FWHM for small animal imaging applications.

  17. Effect of High-speed Milling tool path strategies on the surface roughness of Stavax ESR mold insert machining

    NASA Astrophysics Data System (ADS)

    Mebrahitom, A.; Rizuan, D.; Azmir, M.; Nassif, M.

    2016-02-01

    High speed milling is one of the recent technologies used to produce mould inserts due to the need for high surface finish. It is a faster machining process where it uses a small side step and a small down step combined with very high spindle speed and feed rate. In order to effectively use the HSM capabilities, optimizing the tool path strategies and machining parameters is an important issue. In this paper, six different tool path strategies have been investigated on the surface finish and machining time of a rectangular cavities of ESR Stavax material. CAD/CAM application of CATIA V5 machining module for pocket milling of the cavities was used for process planning.

  18. A rotational and axial motion system load frame insert for in situ high energy x-ray studies

    SciTech Connect

    Shade, Paul A. Schuren, Jay C.; Turner, Todd J.; Blank, Basil; Kenesei, Peter; Goetze, Kurt; Lienert, Ulrich; Almer, Jonathan; Suter, Robert M.; Bernier, Joel V.; Li, Shiu Fai; Lind, Jonathan

    2015-09-15

    High energy x-ray characterization methods hold great potential for gaining insight into the behavior of materials and providing comparison datasets for the validation and development of mesoscale modeling tools. A suite of techniques have been developed by the x-ray community for characterizing the 3D structure and micromechanical state of polycrystalline materials; however, combining these techniques with in situ mechanical testing under well characterized and controlled boundary conditions has been challenging due to experimental design requirements, which demand new high-precision hardware as well as access to high-energy x-ray beamlines. We describe the design and performance of a load frame insert with a rotational and axial motion system that has been developed to meet these requirements. An example dataset from a deforming titanium alloy demonstrates the new capability.

  19. Effect of primordial non-Gaussianities on the far-UV luminosity function of high-redshift galaxies: implications for cosmic reionization

    NASA Astrophysics Data System (ADS)

    Chevallard, Jacopo; Silk, Joseph; Nishimichi, Takahiro; Habouzit, Melanie; Mamon, Gary A.; Peirani, Sébastien

    2015-01-01

    Understanding how the intergalactic medium (IGM) was reionized at z ≳ 6 is one of the big challenges of current high-redshift astronomy. It requires modelling the collapse of the first astrophysical objects (Pop III stars, first galaxies) and their interaction with the IGM, while at the same time pushing current observational facilities to their limits. The observational and theoretical progress of the last few years have led to the emergence of a coherent picture in which the budget of hydrogen-ionizing photons is dominated by low-mass star-forming galaxies, with little contribution from Pop III stars and quasars. The reionization history of the Universe therefore critically depends on the number density of low-mass galaxies at high redshift. In this work, we explore how changes in the cosmological model, and in particular in the statistical properties of initial density fluctuations, affect the formation of early galaxies. Following Habouzit et al. (2014), we run five different N-body simulations with Gaussian and (scale-dependent) non-Gaussian initial conditions, all consistent with Planck constraints. By appealing to a phenomenological galaxy formation model and to a population synthesis code, we compute the far-UV galaxy luminosity function down to MFUV = -14 at redshift 7 ≤ z ≤ 15. We find that models with strong primordial non-Gaussianities on ≲ Mpc scales show a far-UV luminosity function significantly enhanced (up to a factor of 3 at z = 14) in low-mass galaxies. We adopt a reionization model calibrated from state-of-the-art hydrodynamical simulations and show that such scale-dependent non-Gaussianities leave a clear imprint on the Universe reionization history and electron Thomson scattering optical depth τe. Although current uncertainties in the physics of reionization and on the determination of τe still dominate the signatures of non-Gaussianities, our results suggest that τe could ultimately be used to constrain the statistical properties

  20. Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.

    PubMed Central

    Rogers, M. B.; Bennett, T. K.; Payne, C. M.; Smith, C. J.

    1994-01-01

    Bacteroides fragilis is an important opportunistic pathogen of humans and is resistant to many drugs commonly used to treat anaerobic infections, including beta-lactams. A strain set comprised of B. fragilis isolates producing either low or high levels of the endogenous cephalosporinase activity, CepA, has been described previously (M. B. Rogers, A. C. Parker, and C. J. Smith, Antimicrob. Agents Chemother. 37:2391-2400, 1993). Clones containing cepA genes from each of seven representative strains were isolated, and the DNA sequences were determined. Nucleotide sequence comparisons revealed that there were few differences between the cepA coding sequences of the low- and high-activity strains. The cepA coding sequences were cloned into an expression vector, pFD340, and analyzed in a B. fragilis 638 cepA mutant. The results of beta-lactamase assays and ampicillin MICs showed that there was no significant difference in the enzymatic activity of structural genes from the high- or low-activity strains. Comparison of sequences upstream of the cepA coding region revealed that 50 bp prior to the translation start codon, the sequence for high-activity strains change dramatically. This region of the high-activity strains shared extensive homology with IS21, suggesting that an insertion was responsible for the increased expression of cepA in these isolates. Northern (RNA) blot analysis of total RNA by using cepA-specific DNA probes supported the idea that differential cepA expression in low- and high-activity strains was controlled at the level of transcription. However, the insertion did not alter the cepA transcription start site, which occurred 27 bp upstream of the ATG translation start codon in both expression classes. Possible mechanisms of cepA activation are discussed. Images PMID:7517394

  1. The First Detection of [O IV] from an Ultraluminous X-ray Source with Spitzer: Evidence of High Unbeamed Luminosity in Holmberg II ULX

    NASA Technical Reports Server (NTRS)

    Berghea, C. T.; Dudik, R. P.; Weaver, K. A.; Kallman, T. R.

    2008-01-01

    We present the first Spitzer Infrared Spectrograph (IRS) observations of the [O IV] 25.89 micron emission line detected from the ultraluminous X-ray source (ULX) in Holmberg II. This line is a well established signature of high excitation, usually associated with AGN. Its detection suggests that the ULX has a strong impact on the surrounding gas. A Spitzer high resolution spectral map shows that the [O IV] is coincident with the X-ray position of the Holmberg II ULX. We find that the luminosity and the morphology of the line emission is consistent with photoionization by the soft X-ray and far ultraviolet (FUV) radiation from the accretion disk of the binary system and inconsistent with narrow beaming. We show that the emission nebula is radiation bounded both in the line of sight direction and to the west, and probably matter bounded to the east. Evidence for a massive black hole (BH) in this ULX is mounting. Detailed photoionization models favor an intermediate mass black hole of at least 85 Solar Mass as the ionization source for the [OIV] emission. We find that the spectral type of the companion star strongly affects the expected strength of the [O IV] emission. This finding could explain the origin of [O IV] in some starburst galaxies containing black hole binaries.

  2. High pressure coolant effect on PVD coated inserts during end milling of Ti-6AL-4V

    NASA Astrophysics Data System (ADS)

    Sridharan, Arvind

    Titanium alloys are being employed extensively in engineering and aerospace applications for their high strength to weight ratio, mechanical strength and ability to withstand high temperatures. Out of the different alloys of titanium available, the most commonly used alloy is Ti-6Al-4V. It is also called `Grade-5 titanium alloy' or 'α+β titanium alloy'. High speed machining of titanium alloys generates high temperatures in the cutting zone, promoting accelerated tool wear and reducing the efficiency in metal cutting. Consequently, the ability of the coolant to remove heat from the cutting zone plays an increasingly important role in the economics of the process as well as on the life of tool inserts. With the introduction of thru-tool coolant delivery, the coolant can now be delivered directly at the point of machining without having to flood the area of machining. This research tries to address the effects that high pressure and thru-tool coolant has on insert wear while end milling Ti-6Al-4V. The parameters used in this study are speed, feed, axial depth of cut, radial depth of cut and coolant pressure. A structured design of experiments along with a central composite design approach is used to determine the main effects of coolant pressure and its interactions with the remaining parameters. The results show that, within the parameters of this experiment, coolant pressure was not a significant main effect. However, pressure seems to react positively with feed rate. Contributions from this research can be used to recommend settings of the cutting factors in order to obtain the minimal tool wear.

  3. Protostellar Luminosity Functions in 11 Diverse Star Forming Environments

    NASA Astrophysics Data System (ADS)

    Kryukova, Erin; Megeath, S. T.; Gutermuth, R.; Pipher, J.; Allen, T. S.; Allen, L. E.; Myers, P. C.; Muzerolle, J.; Cygnus-X Legacy Team

    2012-01-01

    Protostars exist in a variety of environments, ranging from clouds with dispersed low-mass stars, such as Taurus, to clustered regions in clouds forming high-mass stars, like Orion. The effect these different environments have on protostar properties such as mass or luminosity is uncertain. One way to probe the effects of cloud environment on the observable property, protostar luminosity is to compare protostellar luminosity functions of clouds hosting varied populations of protostars. In this dissertation talk I will discuss the protostellar luminosity functions from 11 star forming clouds including Lupus, Chamaeleon, Ophiuchus, Perseus, Serpens, Orion, Cep OB3, Mon R2, Cygnus-X, and Maddalena's Cloud, which encompass a wide range of star forming environments. The luminosity functions are constructed from Spitzer surveys of these molecular clouds. I employ a new technique for estimating the bolometric luminosity from near and mid-IR fluxes alone and for subtracting contamination from galaxies, reddened pre-main sequence stars with disks, and edge-on disk systems. The clouds which are forming massive stars show a significant peak at low luminosity and a tail extending toward luminosities above 10 solar luminosities, while the luminosity functions of clouds which are not forming massive stars have no significant peak down to the sensitivity limit and do not exhibit the tail. I compare these luminosity functions to existing models of protostellar evolution. I also compare the luminosity functions of protostars in distributed and clustered environments, as determined using nearest-neighbor distances. In Orion and Cygnus-X, the clouds which contain the largest populations of protostars there is a clear difference in luminosity functions between protostars incrowded and distributed regions, with the luminosity function biased towards higher luminosities in more luminous regions. I will discuss the implications of these variations and the possibility that the IMF is

  4. Development and use of a high-fidelity simulator for fetal endotracheal balloon occlusion (FETO) insertion and removal.

    PubMed

    Windrim, Rory; Ryan, Greg; Lebouthillier, Francis; Campisi, Paolo; Kelly, Edmond N; Baud, David; Yoo, Shi-Joon; Deprest, Jan

    2014-02-01

    Objectives The objective of this article is to describe the development of an anatomically accurate simulator in order to aid the training of a perinatal team in the insertion and removal of a fetal endoscopic tracheal occlusion (FETO) balloon in the management of prenatally diagnosed congenital diaphragmatic hernia. Methods An experienced perinatal team collaborated with a medical sculptor to design a fetal model for the FETO procedure. Measurements derived from 28-week fetal magnetic resonance imaging were used in the development of an anatomically precise simulated airway within a silicone rubber preterm fetal model. Clinician feedback was then used to guide multiple iterations of the model with serial improvements in the anatomic accuracy of the simulator airway. Results An appropriately sized preterm fetal mannequin with a high-fidelity airway was developed. The team used this model to develop surgical skills with balloon insertion, and removal, and to prepare the team for an integrated response to unanticipated delivery with the FETO balloon still in situ. Conclusions This fetal mannequin aided in the ability of a fetal therapy unit to offer the FETO procedure at their center for the first time. This model may be of benefit to other perinatal centers planning to offer this procedure. © 2013 John Wiley & Sons, Ltd.

  5. The galactic census of high- and medium-mass protostars. II. Luminosities and evolutionary states of a complete sample of dense gas clumps

    SciTech Connect

    Ma, Bo; Tan, Jonathan C.; Barnes, Peter J.

    2013-12-10

    The Census of High- and Medium-mass Protostars (CHaMP) is the first large-scale (280° < l < 300°, –4° < b < 2°), unbiased, subparsec resolution survey of Galactic molecular clumps and their embedded stars. Barnes et al. presented the source catalog of ∼300 clumps based on HCO{sup +}(1-0) emission, used to estimate masses M. Here we use archival midinfrared-to-millimeter continuum data to construct spectral energy distributions. Fitting two-temperature gray-body models, we derive bolometric luminosities, L. We find that the clumps have 10 ≲ L/L {sub ☉} ≲ 10{sup 6.5} and 0.1 ≲ L/M/[L {sub ☉}/M {sub ☉}] ≲ 10{sup 3}, consistent with a clump population spanning a range of instantaneous star-formation efficiencies from 0 to ∼50%. We thus expect L/M to be a useful, strongly varying indicator of clump evolution during the star cluster formation process. We find correlations of the ratio of warm-to-cold component fluxes and of cold component temperature with L/M. We also find a near-linear relation between L/M and Spitzer-IRAC specific intensity (surface brightness); thus, this relation may also be useful as a star-formation efficiency indicator. The lower bound of the clump L/M distribution suggests that the star-formation efficiency per free-fall time is ε{sub ff} < 0.2. We do not find strong correlations of L/M with mass surface density, velocity dispersion, or virial parameter. We find a linear relation between L and L{sub HCO{sup +}(1--0)}, although with large scatter for any given individual clump. Fitting together with extragalactic systems, the linear relation still holds, extending over 10 orders of magnitude in luminosity. The complete nature of the CHaMP survey over a several kiloparsec-scale region allows us to derive a measurement at an intermediate scale, bridging those of individual clumps and whole galaxies.

  6. High efficiency and enhanced ESD properties of UV LEDs by inserting p-GaN/p-AlGaN superlattice

    NASA Astrophysics Data System (ADS)

    Huang, Yong; Li, PeiXian; Yang, Zhuo; Hao, Yue; Wang, XiaoBo

    2014-05-01

    Significantly improved electrostatic discharge (ESD) properties of InGaN/GaN-based UV light-emitting diode (LED) with inserting p-GaN/p-AlGaN superlattice (p-SLs) layers (instead of p-AlGaN single layer) between multiple quantum wells and Mg-doped GaN layer are reported. The pass yield of the LEDs increased from 73.53% to 93.81% under negative 2000 V ESD pulses. In addition, the light output power (LOP) and efficiency droop at high injection current were also improved. The mechanism of the enhanced ESD properties was then investigated. After excluding the effect of capacitance modulation, high-resolution X-ray diffraction (XRD) and atomic force microscope (AFM) measurements demonstrated that the dominant mechanism of the enhanced ESD properties is the material quality improved by p-SLs, which indicated less leakage paths, rather than the current spreading improved by p-SLs.

  7. Central venous infusion port inserted via high versus low jugular venous approaches: retrospective comparison of outcome and complications.

    PubMed

    Park, Hong Suk; Kim, Young Il; Lee, Sang Hyun; Kim, Jung Im; Seo, Hyobin; Lee, Sang Min; Lee, Youkyung; Lim, Min Kyung; Park, Young Suk

    2009-12-01

    To retrospectively compare immediate and long-term outcome of central venous infusion port inserted via right high versus low jugular vein approaches. The study included 163 patients (125 women patients, 38 men patients; age range, 18-79 years; mean age, 53 years); 142 patients underwent port insertion with low jugular vein approach and 21 patients with high jugular vein approach. The causes of high jugular vein puncture were metastatic lymphadenopathy (n=7), operation scar (n=6), radiation scar (n=5), failure of low jugular vein puncture (n=2), and abnormal course of right subclavian artery (n=1). Medical records and radiologic studies were reviewed retrospectively to determine and compare the outcome and the occurrence of complication related to port. The procedure-related complications were all minor (n=14, 8.6%) in both groups; hematoma (n=4, 2.8% in low jugular puncture group and n=1, 4.8% in high jugular puncture group, p=0.6295), air embolism (n=2, 1.4% in low jugular puncture group and n=0 in high jugular puncture group, p=0.5842) and minor bleeding (n=5, 3.5% in low jugular vein puncture group and n=2, 9.5% in high jugular vein puncture group, p=0.2054). The average length of follow-up was 431 days for low jugular vein puncture group and 284 days for high jugular vein puncture group. The difference between two groups was significant (p=0.0349). The reasons for catheter removal were patients' death (59 in low jugular puncture group and 14 in high jugular puncture group, p=0.0465), suspected infection (11 in low jugular vein puncture group and 2 in high jugular vein puncture group, p=0.8242), catheter occlusion (four in low jugular vein puncture group and one in high jugular vein puncture group, p=0.6583). The catheter tip migrated upward an average of 1.86 cm (range, -0.5 to 5.0 cm) in low jugular vein puncture group and 1.56 cm (range, 0-3.6 cm) in high jugular vein puncture group and there was no significant difference (p=0.4232). Right high jugular vein

  8. Mechanical qualification of the support structure for MQXF, the Nb3Sn low-β quadrupole for the high luminosity LHC

    SciTech Connect

    Juchno, M.; Ambrosio, G.; Anerella, M.; Bajas, H.; Bajko, M.; Bourcey, N.; Cheng, D. W.; Felice, H.; Ferracin, P.; Grosclaude, P.; Guinchard, M.; Perez, J. C.; Prin, H.; Schmalzle, J.

    2016-01-26

    Within the scope of the High Luminosity LHC project, the collaboration between CERN and U.S. LARP is developing new low-β quadrupoles using the Nb3Sn superconducting technology for the upgrade of the LHC interaction regions. The magnet support structure of the first short model was designed and two units were fabricated and tested at CERN and at LBNL. The structure provides the preload to the collars-coils subassembly by an arrangement of outer aluminum shells pre-tensioned with water-pressurized bladders. For the mechanical qualification of the structure and the assembly procedure, superconducting coils were replaced with solid aluminum “dummy coils”, the structure was preloaded at room temperature, and then cooled-down to 77 K. Mechanical behavior of the magnet structure was monitored with the use of strain gauges installed on the aluminum shells, the dummy coils and the axial preload system. As a result, this paper reports on the outcome of the assembly and the cool-down tests with dummy coils, which were performed at CERN and at LBNL, and presents the strain gauge measurements compared to the 3D finite element model predictions.

  9. Mechanical qualification of the support structure for MQXF, the Nb3Sn low-β quadrupole for the high luminosity LHC

    DOE PAGES

    Juchno, M.; Ambrosio, G.; Anerella, M.; ...

    2016-01-26

    Within the scope of the High Luminosity LHC project, the collaboration between CERN and U.S. LARP is developing new low-β quadrupoles using the Nb3Sn superconducting technology for the upgrade of the LHC interaction regions. The magnet support structure of the first short model was designed and two units were fabricated and tested at CERN and at LBNL. The structure provides the preload to the collars-coils subassembly by an arrangement of outer aluminum shells pre-tensioned with water-pressurized bladders. For the mechanical qualification of the structure and the assembly procedure, superconducting coils were replaced with solid aluminum “dummy coils”, the structure wasmore » preloaded at room temperature, and then cooled-down to 77 K. Mechanical behavior of the magnet structure was monitored with the use of strain gauges installed on the aluminum shells, the dummy coils and the axial preload system. As a result, this paper reports on the outcome of the assembly and the cool-down tests with dummy coils, which were performed at CERN and at LBNL, and presents the strain gauge measurements compared to the 3D finite element model predictions.« less

  10. SMA observations on faint submillimeter galaxies with S {sub 850} < 2 mJy: Ultra dusty low-luminosity galaxies at high redshift

    SciTech Connect

    Chen, Chian-Chou; Cowie, Lennox L.; Barger, Amy J.; Williams, Jonathan P.; Wang, Wei-Hao

    2014-07-01

    We obtained Submillimeter Array (SMA) observations of eight faint (intrinsic 850 μm fluxes < 2 mJy) submillimeter galaxies (SMGs) discovered in SCUBA images of the massive lensing cluster fields A370, A2390, and A1689 and detected five. In total, we obtain five SMA detections, all of which have de-lensed fluxes <1 mJy with estimated total infrared luminosities 10{sup 10}-10{sup 12} L {sub ☉}, comparable to luminous infrared galaxies and normal star-forming galaxies. Based on the latest number counts, these galaxies contribute ∼70% of the 850 μm extragalactic background light and represent the dominant star-forming galaxy population in the dusty universe. However, only 40{sub −16}{sup +30}% of our faint SMGs would be detected in deep optical or near-infrared surveys, which suggests many of these sources are at high redshifts (z ≳ 3) or extremely dusty, and they are not included in current star formation history estimates.

  11. SDSS J013127.34–032100.1: A NEWLY DISCOVERED RADIO-LOUD QUASAR AT z = 5.18 WITH EXTREMELY HIGH LUMINOSITY

    SciTech Connect

    Yi, Wei-Min; Bai, Jin-Ming; Zhang, Ju-jia; Wang, Fang; Wang, Jian-Guo; Fan, Yu-Feng; Chang, Liang; Wang, Chuan-Jun; Lun, Bao-Li; Wang, Feige; Wu, Xue-Bing; Yang, Jinyi; Ho, Luis C.; Zuo, Wenwen; Yang, Qian; Ai, Yanli; Fan, Xiaohui; Brandt, William N.; Kim, Minjin; Wang, Ran; and others

    2014-11-10

    Very few of the z > 5 quasars discovered to date have been radio-loud, with radio-to-optical flux ratios (radio-loudness parameters) higher than 10. Here we report the discovery of an optically luminous radio-loud quasar, SDSS J013127.34–032100.1 (J0131–0321 in short), at z = 5.18 ± 0.01 using the Lijiang 2.4 m and Magellan telescopes. J0131–0321 has a spectral energy distribution consistent with that of radio-loud quasars. With an i-band magnitude of 18.47 and a radio flux density of 33 mJy, its radio-loudness parameter is ∼100. The optical and near-infrared spectra taken by Magellan enable us to estimate its bolometric luminosity to be L {sub bol} ∼ 1.1 × 10{sup 48} erg s{sup –1}, approximately 4.5 times greater than that of the most distant quasar known to date. The black hole mass of J0131–0321 is estimated to be 2.7 × 10{sup 9} M {sub ☉}, with an uncertainty up to 0.4 dex. Detailed physical properties of this high-redshift, radio-loud, potentially super-Eddington quasar can be probed in the future with more dedicated and intensive follow-up observations using multi-wavelength facilities.

  12. SDSS J013127.34-032100.1: A Newly Discovered Radio-loud Quasar at z = 5.18 with Extremely High Luminosity

    NASA Astrophysics Data System (ADS)

    Yi, Wei-Min; Wang, Feige; Wu, Xue-Bing; Yang, Jinyi; Bai, Jin-Ming; Fan, Xiaohui; Brandt, William N.; Ho, Luis C.; Zuo, Wenwen; Kim, Minjin; Wang, Ran; Yang, Qian; Zhang, Ju-jia; Wang, Fang; Wang, Jian-Guo; Ai, Yanli; Fan, Yu-Feng; Chang, Liang; Wang, Chuan-Jun; Lun, Bao-Li; Xin, Yu-Xin

    2014-11-01

    Very few of the z > 5 quasars discovered to date have been radio-loud, with radio-to-optical flux ratios (radio-loudness parameters) higher than 10. Here we report the discovery of an optically luminous radio-loud quasar, SDSS J013127.34-032100.1 (J0131-0321 in short), at z = 5.18 ± 0.01 using the Lijiang 2.4 m and Magellan telescopes. J0131-0321 has a spectral energy distribution consistent with that of radio-loud quasars. With an i-band magnitude of 18.47 and a radio flux density of 33 mJy, its radio-loudness parameter is ~100. The optical and near-infrared spectra taken by Magellan enable us to estimate its bolometric luminosity to be L bol ~ 1.1 × 1048 erg s-1, approximately 4.5 times greater than that of the most distant quasar known to date. The black hole mass of J0131-0321 is estimated to be 2.7 × 109 M ⊙, with an uncertainty up to 0.4 dex. Detailed physical properties of this high-redshift, radio-loud, potentially super-Eddington quasar can be probed in the future with more dedicated and intensive follow-up observations using multi-wavelength facilities.

  13. Operational results from the LHC luminosity monitors

    SciTech Connect

    Miyamoto, R.; Ratti, A.; Matis, H.S.; Stezelberger, T.; Turner, W.C.; Yaver, H.; Bravin, E.

    2011-03-28

    The luminosity monitors for the high luminosity regions in the LHC have been operating to monitor and optimize the luminosity since 2009. The device is a gas ionization chamber inside the neutral particle absorber 140 m from the interaction point and monitors showers produced by high energy neutral particles from the collisions. It has the ability to resolve the bunch-by-bunch luminosity as well as to survive the extreme level of radiation in the nominal LHC operation. We present operational results of the device during proton and lead ion operations in 2010 and make comparisons with measurements of experiments. The Large Hadron Collider (LHC) at CERN can accelerate proton and lead ion beams to 7 TeV and 547 TeV and produce collisions of these particles. Luminosity measures performance of the LHC and is particularly important for experiments in high luminosity interaction points (IPs), ATLAS (IP1) and CMS (IP5). To monitor and optimize the luminosities of these IPs, BRAN (Beam RAte Neutral) detectors [1, 2] have been installed and operating since the beginning of the 2009 operation [3]. A neutral particle absorber (TAN) protects the D2 separation dipole from high energy forward neutral particles produced in the collisions [4]. These neutral particles produce electromagnetic and hadronic showers inside the TAN and their energy flux is proportional to the collision rate and hence to the luminosity. The BRAN detector is an Argon gas ionization chamber installed inside the TANs on both sides of the IP1 and IP5 and monitors the relative changes in the luminosity by detecting the ionization due to these showers. When the number of collisions per bunch crossing (multiplicity) is small, the shower rate inside the TAN is also proportional to the luminosity. Hence, the detector is designed to operate by measuring either the shower rate (counting mode for low and intermediate luminosities) or the average shower flux (pulse height mode for high luminosities). The detector is

  14. Efficient DNA fingerprinting based on the targeted sequencing of active retrotransposon insertion sites using a bench-top high-throughput sequencing platform.

    PubMed

    Monden, Yuki; Yamamoto, Ayaka; Shindo, Akiko; Tahara, Makoto

    2014-10-01

    In many crop species, DNA fingerprinting is required for the precise identification of cultivars to protect the rights of breeders. Many families of retrotransposons have multiple copies throughout the eukaryotic genome and their integrated copies are inherited genetically. Thus, their insertion polymorphisms among cultivars are useful for DNA fingerprinting. In this study, we conducted a DNA fingerprinting based on the insertion polymorphisms of active retrotransposon families (Rtsp-1 and LIb) in sweet potato. Using 38 cultivars, we identified 2,024 insertion sites in the two families with an Illumina MiSeq sequencing platform. Of these insertion sites, 91.4% appeared to be polymorphic among the cultivars and 376 cultivar-specific insertion sites were identified, which were converted directly into cultivar-specific sequence-characterized amplified region (SCAR) markers. A phylogenetic tree was constructed using these insertion sites, which corresponded well with known pedigree information, thereby indicating their suitability for genetic diversity studies. Thus, the genome-wide comparative analysis of active retrotransposon insertion sites using the bench-top MiSeq sequencing platform is highly effective for DNA fingerprinting without any requirement for whole genome sequence information. This approach may facilitate the development of practical polymerase chain reaction-based cultivar diagnostic system and could also be applied to the determination of genetic relationships. © The Author 2014. Published by Oxford University Press on behalf of Kazusa DNA Research Institute.

  15. Efficient DNA Fingerprinting Based on the Targeted Sequencing of Active Retrotransposon Insertion Sites Using a Bench-Top High-Throughput Sequencing Platform

    PubMed Central

    Monden, Yuki; Yamamoto, Ayaka; Shindo, Akiko; Tahara, Makoto

    2014-01-01

    In many crop species, DNA fingerprinting is required for the precise identification of cultivars to protect the rights of breeders. Many families of retrotransposons have multiple copies throughout the eukaryotic genome and their integrated copies are inherited genetically. Thus, their insertion polymorphisms among cultivars are useful for DNA fingerprinting. In this study, we conducted a DNA fingerprinting based on the insertion polymorphisms of active retrotransposon families (Rtsp-1 and LIb) in sweet potato. Using 38 cultivars, we identified 2,024 insertion sites in the two families with an Illumina MiSeq sequencing platform. Of these insertion sites, 91.4% appeared to be polymorphic among the cultivars and 376 cultivar-specific insertion sites were identified, which were converted directly into cultivar-specific sequence-characterized amplified region (SCAR) markers. A phylogenetic tree was constructed using these insertion sites, which corresponded well with known pedigree information, thereby indicating their suitability for genetic diversity studies. Thus, the genome-wide comparative analysis of active retrotransposon insertion sites using the bench-top MiSeq sequencing platform is highly effective for DNA fingerprinting without any requirement for whole genome sequence information. This approach may facilitate the development of practical polymerase chain reaction-based cultivar diagnostic system and could also be applied to the determination of genetic relationships. PMID:24935865

  16. Large-scale preparation of graphene by high temperature insertion of hydrogen into graphite.

    PubMed

    Kamali, Ali Reza; Fray, Derek J

    2015-07-14

    Experimental evidence for high temperature diffusion of hydrogen into the interlayer space of graphite is provided. This process is discussed as a possible method for the rapid production of high-quality, inexpensive graphene in large quantities, which could lead to the widespread application of graphene. It was found that hydrogen cations, dissolved in molten LiCl, can be discharged on cathodically polarized graphite rods, which then intercalate into the graphite structure, leading to the peeling of graphite to produce graphene. The graphene nanosheets produced displayed a single-crystalline structure with a lateral size of several hundred nanometers and a high degree of crystallinity and thermal stability. The method introduced could be scaled up to produce industrial quantities of high-quality graphene.

  17. Cermet insert high voltage holdoff for ceramic/metal vacuum devices

    DOEpatents

    Ierna, William F.

    1987-01-01

    An improved metal-to-ceramic seal is provided wherein the ceramic body of the seal contains an integral region of cermet material in electrical contact with the metallic member, e.g., an electrode, of the seal. The seal is useful in high voltage vacuum devices, e.g., vacuum switches, and increases the high-voltage holdoff capabilities of such devices. A method of fabricating such seals is also provided.

  18. Cermet insert high voltage holdoff improvement for ceramic/metal vacuum devices

    DOEpatents

    Ierna, W.F.

    1986-03-11

    An improved metal-to-ceramic seal is provided wherein the ceramic body of the seal contains an integral region of cermet material in electrical contact with the metallic member, e.g., an electrode, of the seal. The seal is useful in high voltage vacuum devices, e.g., vacuum switches, and increases the high-voltage holdoff capabilities of such devices. A method of fabricating such seals is also provided.

  19. Insertion of N2 into the Channels of AFI Zeolite under High Pressure

    PubMed Central

    Lv, Hang; yao, Mingguang; Li, Quanjun; Liu, Ran; Liu, Bo; Yao, Zhen; Liu, Dedi; Liu, Zhaodong; Liu, Jing; Chen, Zhiqiang; Zou, Bo; Cui, Tian; Liu, Bingbing

    2015-01-01

    We present an experimental study of a new hybrid material where nitrogen is encapsulated in the channels of porous zeolite AlPO4-5 (AFI) single crystals by a high-pressure method. The high-pressure behavior of nitrogen confined inside the AFI nano-channels is then investigated by Raman spectroscopy up to 44 GPa. Under pressure, the Raman modes of confined nitrogen show behaviors different from those of the bulk nitrogen. After the return to atmospheric pressure, it is demonstrated that non-gaseous nitrogen can be effectively stabilized by being confined inside the intact AFI sample. This result provides new insight into nitrogen capture and storage technologies. PMID:26282881

  20. The high-mass end of the red sequence at z ˜ 0.55 from SDSS-III/BOSS: completeness, bimodality and luminosity function

    NASA Astrophysics Data System (ADS)

    Montero-Dorta, Antonio D.; Bolton, Adam S.; Brownstein, Joel R.; Swanson, Molly; Dawson, Kyle; Prada, Francisco; Eisenstein, Daniel; Maraston, Claudia; Thomas, Daniel; Comparat, Johan; Chuang, Chia-Hsun; McBride, Cameron K.; Favole, Ginevra; Guo, Hong; Rodríguez-Torres, Sergio; Schneider, Donald P.

    2016-09-01

    We have developed an analytical method based on forward-modelling techniques to characterize the high-mass end of the red sequence (RS) galaxy population at redshift z ˜ 0.55, from the DR10 BOSS (Baryon Oscillation Spectroscopic Survey) CMASS spectroscopic sample, which comprises ˜600 000 galaxies. The method, which follows an unbinned maximum likelihood approach, allows the deconvolution of the intrinsic CMASS colour-colour-magnitude distributions from photometric errors and selection effects. This procedure requires modelling the covariance matrix for the i-band magnitude, g - r colour and r - i colour using Stripe 82 multi-epoch data. Our results indicate that the error-deconvolved intrinsic RS distribution is consistent, within the photometric uncertainties, with a single point (<0.05 mag) in the colour-colour plane at fixed magnitude, for a narrow redshift slice. We have computed the high-mass end (0.55Mi ≲ -22) of the 0.55i-band RS luminosity function (RS LF) in several redshift slices within the redshift range 0.52 < z < 0.63. In this narrow redshift range, the evolution of the RS LF is consistent, within the uncertainties in the modelling, with a passively evolving model with Φ* = (7.248 ± 0.204) × 10- 4 Mpc-3 mag-1, fading at a rate of 1.5 ± 0.4 mag per unit redshift. We report RS completeness as a function of magnitude and redshift in the CMASS sample, which will facilitate a variety of galaxy-evolution and clustering studies using BOSS. Our forward-modelling method lays the foundations for future studies using other dark-energy surveys like the Extended Baryon Oscillation Spectroscopic Survey or the Dark Energy Spectroscopic Instrument, which are affected by the same type of photometric blurring/selection effects.

  1. MAGIC detection of very high energy γ-ray emission from the low-luminosity blazar 1ES 1741+196

    NASA Astrophysics Data System (ADS)

    Ahnen, M. L.; Ansoldi, S.; Antonelli, L. A.; Antoranz, P.; Arcaro, C.; Babic, A.; Banerjee, B.; Bangale, P.; Barres de Almeida, U.; Barrio, J. A.; Bednarek, W.; Bernardini, E.; Berti, A.; Biasuzzi, B.; Biland, A.; Blanch, O.; Bonnefoy, S.; Bonnoli, G.; Borracci, F.; Bretz, T.; Buson, S.; Carosi, A.; Chatterjee, A.; Clavero, R.; Colin, P.; Colombo, E.; Contreras, J. L.; Cortina, J.; Covino, S.; Da Vela, P.; Dazzi, F.; De Angelis, A.; De Lotto, B.; de Oña Wilhelmi, E.; Di Pierro, F.; Doert, M.; Domínguez, A.; Dominis Prester, D.; Dorner, D.; Doro, M.; Einecke, S.; Eisenacher Glawion, D.; Elsaesser, D.; Engelkemeier, M.; Fallah Ramazani, V.; Fernández-Barral, A.; Fidalgo, D.; Fonseca, M. V.; Font, L.; Frantzen, K.; Fruck, C.; Galindo, D.; García López, R. J.; Garczarczyk, M.; Garrido Terrats, D.; Gaug, M.; Giammaria, P.; Godinović, N.; Gora, D.; Guberman, D.; Hadasch, D.; Hahn, A.; Hayashida, M.; Herrera, J.; Hose, J.; Hrupec, D.; Hughes, G.; Idec, W.; Kodani, K.; Konno, Y.; Kubo, H.; Kushida, J.; La Barbera, A.; Lelas, D.; Lindfors, E.; Lombardi, S.; Longo, F.; López, M.; López-Coto, R.; Majumdar, P.; Makariev, M.; Mallot, K.; Maneva, G.; Manganaro, M.; Mankuzhiyil, N.; Mannheim, K.; Maraschi, L.; Marcote, B.; Mariotti, M.; Martínez, M.; Mazin, D.; Menzel, U.; Miranda, J. M.; Mirzoyan, R.; Moralejo, A.; Moretti, E.; Nakajima, D.; Neustroev, V.; Niedzwiecki, A.; Nievas Rosillo, M.; Nilsson, K.; Nishijima, K.; Noda, K.; Nogués, L.; Paiano, S.; Palacio, J.; Palatiello, M.; Paneque, D.; Paoletti, R.; Paredes, J. M.; Paredes-Fortuny, X.; Pedaletti, G.; Peresano, M.; Perri, L.; Persic, M.; Poutanen, J.; Prada Moroni, P. G.; Prandini, E.; Puljak, I.; Garcia, J. R.; Reichardt, I.; Rhode, W.; Ribó, M.; Rico, J.; Saito, T.; Satalecka, K.; Schroeder, S.; Schweizer, T.; Shore, S. N.; Sillanpää, A.; Sitarek, J.; Snidaric, I.; Sobczynska, D.; Stamerra, A.; Strzys, M.; Surić, T.; Takalo, L.; Takami, H.; Tavecchio, F.; Temnikov, P.; Terzić, T.; Tescaro, D.; Teshima, M.; Torres, D. F.; Toyama, T.; Treves, A.; Vanzo, G.; Verguilov, V.; Vovk, I.; Ward, J. E.; Will, M.; Wu, M. H.; Zanin, R.; Becerra González, J.; Rani, B.; Krauss, F.; Perri, M.; Verrecchia, F.; Reinthal, R.

    2017-06-01

    We present the first detection of the nearby (z = 0.084) low-luminosity BL Lac object 1ES 1741+196 in the very high energy (E > 100 GeV) band. This object lies in a triplet of interacting galaxies. Early predictions had suggested 1ES 1741+196 to be, along with several other high-frequency BL Lac sources, within the reach of MAGIC detectability. Its detection by MAGIC, later confirmed by VERITAS, helps to expand the small population of known TeV BL Lacs. The source was observed with the MAGIC telescopes between 2010 April and 2011 May, collecting 46 h of good quality data. These observations led to the detection of the source at 6.0 σ confidence level, with a steady flux F(>100 GeV) = (6.4 ± 1.7stat ± 2.6syst) × 10-12 ph cm-2s-1 and a differential spectral photon index Γ = 2.4 ± 0.2stat ± 0.2syst in the range of ˜80 GeV-3 TeV. To study the broad-band spectral energy distribution (SED) simultaneous with MAGIC observations, we use KVA, Swift/UVOT and XRT and Fermi/LAT data. One-zone synchrotron-self-Compton (SSC) modelling of the SED of 1ES 1741+196 suggests values for the SSC parameters that are quite common among known TeV BL Lacs except for a relatively low Doppler factor and slope of electron energy distribution. A thermal feature seen in the SED is well matched by a giant elliptical's template. This appears to be the signature of thermal emission from the host galaxy, which is clearly resolved in optical observations.

  2. MAGIC detection of very high energy γ-ray emission from the low-luminosity blazar 1ES 1741+196

    DOE PAGES

    Ahnen, M. L.; Ansoldi, S.; Antonelli, L. A.; ...

    2017-02-23

    Here, we present the first detection of the nearby (z = 0.084) low-luminosity BL Lac object 1ES 1741+196 in the very high energy (E > 100 GeV) band. This object lies in a triplet of interacting galaxies. Early predictions had suggested 1ES 1741+196 to be, along with several other high-frequency BL Lac sources, within the reach of MAGIC detectability. Its detection by MAGIC, later confirmed by VERITAS, helps to expand the small population of known TeV BL Lacs. The source was observed with the MAGIC telescopes between 2010 April and 2011 May, collecting 46 h of good quality data. Thesemore » observations led to the detection of the source at 6.0 σ confidence level, with a steady flux F(>100 GeV) = (6.4 ± 1.7stat ± 2.6syst) × 10–12 ph cm–2s–1 and a differential spectral photon index Γ = 2.4 ± 0.2stat ± 0.2syst in the range of ~80 GeV–3 TeV. To study the broad-band spectral energy distribution (SED) simultaneous with MAGIC observations, we use KVA, Swift/UVOT and XRT and Fermi/LAT data. One-zone synchrotron-self-Compton (SSC) modelling of the SED of 1ES 1741+196 suggests values for the SSC parameters that are quite common among known TeV BL Lacs except for a relatively low Doppler factor and slope of electron energy distribution. A thermal feature seen in the SED is well matched by a giant elliptical's template. As a result, this appears to be the signature of thermal emission from the host galaxy, which is clearly resolved in optical observations.« less

  3. Different Luminosity Correlation of GRBs

    NASA Astrophysics Data System (ADS)

    Zhang, Z. B.; Liu, H. C.; Jiang, L. Y.; Chen, D. Y.

    2014-09-01

    We report our recent understanding about a tight correlation between relative spectral lag and luminosity (or redshift) for γ-ray bursts. The latest investigations indicate that the empirical correlations got from BATSE bursts also exist for Swift/BAT ones. The special luminosity-lag correlation is much similar to that of the luminosity with pulse number proposed by Schaefer (2003), but largely different from most of others ever discovered. Note that our newly built luminosity-lag correlation predicts that luminosity should evolve with cosmological redshift as L p ∝ (1 + z)2.4±0.7 that is excellently confirmed by Salvaterra et al. (2012) and Geng & Huang (2013). In addition, it is also surprisingly found that the luminosity-lag correlation can account for both long and short Swift/BAT bursts, which might be an evidence of the same radiation mechanism for diverse burst groups.

  4. Insertion Sequences

    PubMed Central

    Mahillon, Jacques; Chandler, Michael

    1998-01-01

    Insertion sequences (ISs) constitute an important component of most bacterial genomes. Over 500 individual ISs have been described in the literature to date, and many more are being discovered in the ongoing prokaryotic and eukaryotic genome-sequencing projects. The last 10 years have also seen some striking advances in our understanding of the transposition process itself. Not least of these has been the development of various in vitro transposition systems for both prokaryotic and eukaryotic elements and, for several of these, a detailed understanding of the transposition process at the chemical level. This review presents a general overview of the organization and function of insertion sequences of eubacterial, archaebacterial, and eukaryotic origins with particular emphasis on bacterial elements and on different aspects of the transposition mechanism. It also attempts to provide a framework for classification of these elements by assigning them to various families or groups. A total of 443 members of the collection have been grouped in 17 families based on combinations of the following criteria: (i) similarities in genetic organization (arrangement of open reading frames); (ii) marked identities or similarities in the enzymes which mediate the transposition reactions, the recombinases/transposases (Tpases); (iii) similar features of their ends (terminal IRs); and (iv) fate of the nucleotide sequence of their target sites (generation of a direct target duplication of determined length). A brief description of the mechanism(s) involved in the mobility of individual ISs in each family and of the structure-function relationships of the individual Tpases is included where available. PMID:9729608

  5. Apparatus for inserting and removing specimens from high temperature vacuum furnaces

    NASA Technical Reports Server (NTRS)

    Whitehead, C. W. (Inventor)

    1974-01-01

    The apparatus comprises a high speed gate valve for isolating the interior of the furnance from an air lock chamber on the opposite side of the gate valve. The air lock chamber is provided with valve ports connected to a vacuum source, a source of inert quenching gas, and the atmosphere, respectively. Attached to the end of the air lock chamber away from the furnace is a cylindrical tube having disposed within it a rod carrying specimen pan at the end towards the furnace and having mounted at its top end an annular magnet having a diameter slightly less than the interior diameter of the tube. The top end of the tube is closed by a removeable cap. Encircling the tube in the vicinity of the magnet is a carbon steel ring which when axially moved along the tube causes the magnet to follow it and thereby controls the position of the rod and specimen pan within the tube.

  6. High-Throughput Parallel Sequencing to Measure Fitness of Leptospira interrogans Transposon Insertion Mutants during Acute Infection

    PubMed Central

    Matsunaga, James; Haake, David A.

    2016-01-01

    Pathogenic species of Leptospira are the causative agents of leptospirosis, a zoonotic disease that causes mortality and morbidity worldwide. The understanding of the virulence mechanisms of Leptospira spp is still at an early stage due to the limited number of genetic tools available for this microorganism. The development of random transposon mutagenesis in pathogenic strains a decade ago has contributed to the identification of several virulence factors. In this study, we used the transposon sequencing (Tn-Seq) technique, which combines transposon mutagenesis with massive parallel sequencing, to study the in vivo fitness of a pool of Leptospira interrogans mutants. We infected hamsters with a pool of 42 mutants (input pool), which included control mutants with insertions in four genes previously analyzed by virulence testing (loa22, ligB, flaA1, and lic20111) and 23 mutants with disrupted signal transduction genes. We quantified the mutants in different tissues (blood, kidney and liver) at 4 days post-challenge by high-throughput sequencing and compared the frequencies of mutants recovered from tissues to their frequencies in the input pool. Control mutants that were less fit in the Tn-Seq experiment were attenuated for virulence when tested separately in the hamster model of lethal leptospirosis. Control mutants with unaltered fitness were as virulent as the wild-type strain. We identified two mutants with the transposon inserted in the same putative adenylate/guanylate cyclase gene (lic12327) that had reduced in vivo fitness in blood, kidney and liver. Both lic12327 mutants were attenuated for virulence when tested individually in hamsters. Growth of the control mutants and lic12327 mutants in culture medium were similar to that of the wild-type strain. These results demonstrate the feasibility of screening large pools of L. interrogans transposon mutants for those with altered fitness, and potentially attenuated virulence, by transposon sequencing. PMID

  7. High-Throughput Parallel Sequencing to Measure Fitness of Leptospira interrogans Transposon Insertion Mutants during Acute Infection.

    PubMed

    Lourdault, Kristel; Matsunaga, James; Haake, David A

    2016-11-01

    Pathogenic species of Leptospira are the causative agents of leptospirosis, a zoonotic disease that causes mortality and morbidity worldwide. The understanding of the virulence mechanisms of Leptospira spp is still at an early stage due to the limited number of genetic tools available for this microorganism. The development of random transposon mutagenesis in pathogenic strains a decade ago has contributed to the identification of several virulence factors. In this study, we used the transposon sequencing (Tn-Seq) technique, which combines transposon mutagenesis with massive parallel sequencing, to study the in vivo fitness of a pool of Leptospira interrogans mutants. We infected hamsters with a pool of 42 mutants (input pool), which included control mutants with insertions in four genes previously analyzed by virulence testing (loa22, ligB, flaA1, and lic20111) and 23 mutants with disrupted signal transduction genes. We quantified the mutants in different tissues (blood, kidney and liver) at 4 days post-challenge by high-throughput sequencing and compared the frequencies of mutants recovered from tissues to their frequencies in the input pool. Control mutants that were less fit in the Tn-Seq experiment were attenuated for virulence when tested separately in the hamster model of lethal leptospirosis. Control mutants with unaltered fitness were as virulent as the wild-type strain. We identified two mutants with the transposon inserted in the same putative adenylate/guanylate cyclase gene (lic12327) that had reduced in vivo fitness in blood, kidney and liver. Both lic12327 mutants were attenuated for virulence when tested individually in hamsters. Growth of the control mutants and lic12327 mutants in culture medium were similar to that of the wild-type strain. These results demonstrate the feasibility of screening large pools of L. interrogans transposon mutants for those with altered fitness, and potentially attenuated virulence, by transposon sequencing.

  8. Y-TZP zirconia run against highly crosslinked UHMWPE tibial inserts: knee simulator wear and phase-transformation studies.

    PubMed

    Tsukamoto, Riichiro; Williams, Paul A; Clarke, Ian C; Pezzotti, Giuseppe; Shoji, Hiromu; Akagi, Masao; Yamamoto, Kengo

    2008-07-01

    Zirconia (ZrO(2)) ceramics combined with highly cross-linked polyethylene appears to be a promising approach to minimize wear in artificial knee joints. The wear performance of yttria-stabilized zirconia (YZr) femoral condyles on 7-Mrad tibial inserts was compared in a knee simulator to CoCr bearing on 3.5-Mrad inserts. The knee design was the Bi-Surface type with a 9-year clinical history in Japan (JMM, Japan). A displacement-controlled knee simulator was used with kinematics that included 20 degrees flexion, +/-5 degrees rotation, and 6 mm anterior/posterior translation. Lubricant was alpha-calf serum, test duration was 10 million cycles (10 Mc), and wear was measured by weight-loss techniques. The wear zones were studied by laser interferometry, scanning electron microscopy, and Raman microprobe spectroscopy. At 10 Mc the wear rates of the CoCr controls averaged 4.5 mm(3)/Mc. This was within 7% of the prior estimate at 5-Mc duration and comparable to Bi-Surface wear data from another laboratory. The CoCr condyles increased in roughness (R(a)) from <50 nm to average R(a) = 250 nm due to linear scratching. The ceramic condyles remained pristine throughout the wear study (R(a) <7 nm). With the YZr/7-Mrad combination, the weight change had a positive slope over at 10 Mc, which meant that the actual polyethylene wear was unmeasurable. Microscopic examinations at 10 Mc showed that the zirconia surfaces were intact and there was no detectable change from tetragonal to monoclinic phase. Our laboratory knee wear simulation appeared very supportive of the 9-year YZr/PE clinical results with Bi-Surface total knee replacements in Japan. 2007 Wiley Periodicals, Inc.

  9. THE STRUCTURE AND SPECTRAL FEATURES OF A THIN DISK AND EVAPORATION-FED CORONA IN HIGH-LUMINOSITY ACTIVE GALACTIC NUCLEI

    SciTech Connect

    Liu, J. Y.; Mineshige, S. E-mail: bfliu@nao.cas.cn

    2012-08-01

    We investigate the accretion process in high-luminosity active galactic nuclei (HLAGNs) in the scenario of the disk evaporation model. Based on this model, the thin disk can extend down to the innermost stable circular orbit (ISCO) at accretion rates higher than 0.02 M-dot{sub Edd} while the corona is weak since part of the coronal gas is cooled by strong inverse Compton scattering of the disk photons. This implies that the corona cannot produce as strong X-ray radiation as observed in HLAGNs with large Eddington ratio. In addition to the viscous heating, other heating to the corona is necessary to interpret HLAGN. In this paper, we assume that a part of accretion energy released in the disk is transported into the corona, heating up the electrons, and is thereby radiated away. For the first time, we compute the corona structure with additional heating, fully taking into account the mass supply to the corona, and find that the corona could indeed survive at higher accretion rates and that its radiation power increases. The spectra composed of bremsstrahlung and Compton radiation are also calculated. Our calculations show that the Compton-dominated spectrum becomes harder with the increase of energy fraction (f) liberating in the corona, and the photon index for hard X-ray (2-10 keV) is 2.2 < {Gamma} < 2.7. We discuss possible heating mechanisms for the corona. Combining the energy fraction transported to the corona with the accretion rate by magnetic heating, we find that the hard X-ray spectrum becomes steeper at a larger accretion rate and the bolometric correction factor (L{sub bol}/L{sub 2-10keV}) increases with increasing accretion rate for f < 8/35, which is roughly consistent with the observational results.

  10. High-Throughput Genotyping of Green Algal Mutants Reveals Random Distribution of Mutagenic Insertion Sites and Endonucleolytic Cleavage of Transforming DNA.

    PubMed

    Zhang, Ru; Patena, Weronika; Armbruster, Ute; Gang, Spencer S; Blum, Sean R; Jonikas, Martin C

    2014-04-01

    A high-throughput genetic screening platform in a single-celled photosynthetic eukaryote would be a transformative addition to the plant biology toolbox. Here, we present ChlaMmeSeq (Chlamydomonas MmeI-based insertion site Sequencing), a tool for simultaneous mapping of tens of thousands of mutagenic insertion sites in the eukaryotic unicellular green alga Chlamydomonas reinhardtii. We first validated ChlaMmeSeq by in-depth characterization of individual insertion sites. We then applied ChlaMmeSeq to a mutant pool and mapped 11,478 insertions, covering 39% of annotated protein coding genes. We observe that insertions are distributed in a manner largely indistinguishable from random, indicating that mutants in nearly all genes can be obtained efficiently. The data reveal that sequence-specific endonucleolytic activities cleave the transforming DNA and allow us to propose a simple model to explain the origin of the poorly understood exogenous sequences that sometimes surround insertion sites. ChlaMmeSeq is quantitatively reproducible, enabling its use for pooled enrichment screens and for the generation of indexed mutant libraries. Additionally, ChlaMmeSeq allows genotyping of hits from Chlamydomonas screens on an unprecedented scale, opening the door to comprehensive identification of genes with roles in photosynthesis, algal lipid metabolism, the algal carbon-concentrating mechanism, phototaxis, the biogenesis and function of cilia, and other processes for which C. reinhardtii is a leading model system.

  11. The DA{phi}NE luminosity monitor

    SciTech Connect

    Di Pirro, G.; Drago, A.; Ghigo, A.; Mazzitelli, G.; Preger, M.; Sannibale, F.; Serio, M.; Vignola, G.; Cervelli, F.; Lomtadze, T.

    1998-12-10

    DA{phi}NE, the Frascati {phi}-factory, is an e{sup +}/e{sup -} collider with 2 interaction points (IPs). The center of mass energy is 1020 MeV and the design luminosity 4.2x10{sup 30} cm{sup -2} s{sup -1} in single bunch mode and 5x10{sup 32} cm{sup -2} s{sup -1} in multibunch mode. Between the possible electromagnetic reactions at the interaction point, single bremsstrahlung (SB) has been selected for the luminosity measurement. The SB high counting rate allows real-time monitoring, which is very useful during machine tune-up and moreover the narrow peak of the SB angular distribution makes the counting rate almost independent from the beam position at the IP. A description of the experimental set-up, calibration results and luminosity measurements is presented.

  12. Direct measurement of solar luminosity variation.

    PubMed

    Willson, R C; Duncan, C H; Geist, J

    1980-01-11

    Two rocket flights of an absolute pyrheliometer, separated by 30 months, indicate an increase in solar luminosity (solar constant) of 0.4 percent. The significance of this result is considered in light of the instrument performance during the rocket flights and of pre- and postflight intercomparisons with independently maintained pyrheliometers. There is a high probability that the measured difference is real. Additional observations are required to determine whether the difference results from random fluctuations in solar luminosity, a nonrandom change of short duration, or a sustained change that has climatological significance.

  13. High-resolution definition of the Vibrio cholerae essential gene set with hidden Markov model-based analyses of transposon-insertion sequencing data.

    PubMed

    Chao, Michael C; Pritchard, Justin R; Zhang, Yanjia J; Rubin, Eric J; Livny, Jonathan; Davis, Brigid M; Waldor, Matthew K

    2013-10-01

    The coupling of high-density transposon mutagenesis to high-throughput DNA sequencing (transposon-insertion sequencing) enables simultaneous and genome-wide assessment of the contributions of individual loci to bacterial growth and survival. We have refined analysis of transposon-insertion sequencing data by normalizing for the effect of DNA replication on sequencing output and using a hidden Markov model (HMM)-based filter to exploit heretofore unappreciated information inherent in all transposon-insertion sequencing data sets. The HMM can smooth variations in read abundance and thereby reduce the effects of read noise, as well as permit fine scale mapping that is independent of genomic annotation and enable classification of loci into several functional categories (e.g. essential, domain essential or 'sick'). We generated a high-resolution map of genomic loci (encompassing both intra- and intergenic sequences) that are required or beneficial for in vitro growth of the cholera pathogen, Vibrio cholerae. This work uncovered new metabolic and physiologic requirements for V. cholerae survival, and by combining transposon-insertion sequencing and transcriptomic data sets, we also identified several novel noncoding RNA species that contribute to V. cholerae growth. Our findings suggest that HMM-based approaches will enhance extraction of biological meaning from transposon-insertion sequencing genomic data.

  14. High-resolution definition of the Vibrio cholerae essential gene set with hidden Markov model–based analyses of transposon-insertion sequencing data

    PubMed Central

    Chao, Michael C.; Pritchard, Justin R.; Zhang, Yanjia J.; Rubin, Eric J.; Livny, Jonathan; Davis, Brigid M.; Waldor, Matthew K.

    2013-01-01

    The coupling of high-density transposon mutagenesis to high-throughput DNA sequencing (transposon-insertion sequencing) enables simultaneous and genome-wide assessment of the contributions of individual loci to bacterial growth and survival. We have refined analysis of transposon-insertion sequencing data by normalizing for the effect of DNA replication on sequencing output and using a hidden Markov model (HMM)-based filter to exploit heretofore unappreciated information inherent in all transposon-insertion sequencing data sets. The HMM can smooth variations in read abundance and thereby reduce the effects of read noise, as well as permit fine scale mapping that is independent of genomic annotation and enable classification of loci into several functional categories (e.g. essential, domain essential or ‘sick’). We generated a high-resolution map of genomic loci (encompassing both intra- and intergenic sequences) that are required or beneficial for in vitro growth of the cholera pathogen, Vibrio cholerae. This work uncovered new metabolic and physiologic requirements for V. cholerae survival, and by combining transposon-insertion sequencing and transcriptomic data sets, we also identified several novel noncoding RNA species that contribute to V. cholerae growth. Our findings suggest that HMM-based approaches will enhance extraction of biological meaning from transposon-insertion sequencing genomic data. PMID:23901011

  15. The BRAN luminosity detectors for the LHC

    NASA Astrophysics Data System (ADS)

    Matis, H. S.; Placidi, M.; Ratti, A.; Turner, W. C.; Bravin, E.; Miyamoto, R.

    2017-03-01

    This paper describes the several phases which led, from the conceptual design, prototyping, construction and tests with beam, to the installation and operation of the BRAN (Beam RAte of Neutrals) relative luminosity monitors for the LHC. The detectors have been operating since 2009 to contribute, optimize and maintain the accelerator performance in the two high luminosity interaction regions (IR), the IR1 (ATLAS) and the IR5 (CMS). The devices are gas ionization chambers installed inside a neutral particle absorber 140 m away from the Interaction Points in IR1 and IR5 and monitor the energy deposited by electromagnetic showers produced by high-energy neutral particles from the collisions. The detectors have the capability to resolve the bunch-by-bunch luminosity at the 40 MHz bunch rate, as well as to survive the extreme level of radiation during the nominal LHC operation. The devices have operated since the early commissioning phase of the accelerator over a broad range of luminosities reaching 1.4×1034 cm-2 s-1 with a peak pileup of 45 events per bunch crossing. Even though the nominal design luminosity of the LHC has been exceeded, the BRAN is operating well. After describing how the BRAN can be used to monitor the luminosity of the collider, we discuss the technical choices that led to its construction and the different tests performed prior to the installation in two IRs of the LHC. Performance simulations are presented together with operational results obtained during p-p operations, including runs at 40 MHz bunch rate, Pb-Pb operations and p-Pb operations.

  16. ALS insertion devices

    NASA Astrophysics Data System (ADS)

    Hoyer, E.; Chin, J.; Halbach, K.; Hassenzahl, W. V.; Humphries, D.; Kincaid, B.; Lancaster, H.; Plate, D.

    1991-08-01

    The Advanced Light Source (ALS), the first US third generation synchrotron radiation source, is currently under construction at the Lawrence Berkeley Laboratory. The low-emittance, 1.5 GeV electron storage ring and the insertion devices are specifically designed to produce high brightness beams in the UV to soft X-Ray range. The planned initial complement of insertion devices includes four 4.6 m long undulators, with period lengths of 3.9 cm, 5.0 cm (2) and 8.0 cm, and a 2.9 m long wiggler of 16 cm period length. Undulator design is well advanced and fabrication has begun on the 5.0 cm and 8.0 cm period length undulators. This paper discusses ALS insertion device requirements; general design philosophy; and design of the magnetic structure, support structure/drive systems, control system and vacuum system.

  17. Association of an HLA-G 14-bp Insertion/Deletion polymorphism with high HBV replication in chronic hepatitis.

    PubMed

    Laaribi, A B; Zidi, I; Hannachi, N; Ben Yahia, H; Chaouch, H; Bortolotti, D; Zidi, N; Letaief, A; Yacoub, S; Boudabous, A; Rizzo, R; Boukadida, J

    2015-10-01

    Identification of an HLA-G 14-bp Insertion/Deletion (Ins/Del) polymorphism at the 3' untranslated region of HLA-G revealed its importance in HLA-G mRNA stability and HLA-G protein level variation. We evaluated the association between the HLA-G 14-bp Ins/Del polymorphism in patients with chronic Hepatitis B virus (HBV) infection in a case-control study. Genomic DNA was extracted from 263 patients with chronic HBV hepatitis and 246 control subjects and was examined for the HLA-G 14-bp Ins/Del polymorphism by PCR. The polymorphic variants were genotyped in chronic HBV seropositive cases stratified according to HBV DNA levels, fibrosis stages and in a control population. There was no statistical significant association between the 14-bp Ins/Del polymorphism and increased susceptibility to HBV infection neither for alleles (P = 0.09) nor for genotypes (P = 0.18). The stratification of HBV patients based on HBV DNA levels revealed an association between the 14-bp Ins/Del polymorphism and an enhanced HBV activity with high HBV DNA levels. In particular, the Ins allele was significantly associated with high HBV DNA levels (P = 0.0024, OR = 1.71, 95% CI 1.2-2.4). The genotype Ins/Ins was associated with a 2.5-fold (95% CI, 1.29-4.88) increased risk of susceptibility to high HBV replication compared with the Del/Del and Ins/Del genotypes. This susceptibility is linked to the presence of two Ins alleles. No association was observed between the 14-bp Ins/Del polymorphism and fibrosis stage of HBV infection. We observed an association between the 14-bp Ins/Del polymorphism and high HBV replication characterized by high HBV DNA levels in chronic HBV patients. These results suggest a potential prognostic value for disease outcome evaluation.

  18. Impedance calculation for ferrite inserts

    SciTech Connect

    Breitzmann, S.C.; Lee, S.Y.; Ng, K.Y.; /Fermilab

    2005-01-01

    Passive ferrite inserts were used to compensate the space charge impedance in high intensity space charge dominated accelerators. They study the narrowband longitudinal impedance of these ferrite inserts. they find that the shunt impedance and the quality factor for ferrite inserts are inversely proportional to the imaginary part of the permeability of ferrite materials. They also provide a recipe for attaining a truly passive space charge impedance compensation and avoiding narrowband microwave instabilities.

  19. First Detection of the [O(sub III)] 88 Micrometers Line at High Redshifts: Characterizing the Starburst and Narrow-Line Regions in Extreme Luminosity Systems

    NASA Technical Reports Server (NTRS)

    Ferkinhoff, C.; Hailey-Dunsheath, S.; Nikola, T.; Parshley, S. C.; Stacey, G. J.; Benford, D. J.; Staguhn, J. G.

    2010-01-01

    We have made the first detections of the 88 micrometers [O(sub III)] line from galaxies in the early universe, detecting the line from the lensed active galactic nucleus (AGN)/starburst composite systems APM 08279+5255 at z 3.911 and SMM J02399-0136 at z = 2.8076. The line is exceptionally bright from both systems, with apparent (lensed) luminosities approx.10(exp 11) Solar Luminosity, For APM 08279, the [O(sub III)] line flux can be modeled in a star formation paradigm, with the stellar radiation field dominated by stars with effective temperatures, T(sub eff) > 36,000 K, similar to the starburst found in M82. The model implies approx.35% of the total far-IR luminosity of the system is generated by the starburst, with the remainder arising from dust heated by the AGN. The 881,tm line can also be generated in the narrow-line region of the AGN if gas densities are around a few 1000 cu cm. For SMM J02399, the [O(sub III)] line likely arises from HII regions formed by hot (T(sub eff) > 40,000 K) young stars in a massive starburst that dominates the far-IR luminosity of the system. The present work demonstrates the utility of the [O(sub III)] line for characterizing starbursts and AGN within galaxies in the early universe. These are the first detections of this astrophysically important line from galaxies beyond a redshift of 0.05.s

  20. First Detection of the [O(sub III)] 88 Micrometers Line at High Redshifts: Characterizing the Starburst and Narrow-Line Regions in Extreme Luminosity Systems

    NASA Technical Reports Server (NTRS)

    Ferkinhoff, C.; Hailey-Dunsheath, S.; Nikola, T.; Parshley, S. C.; Stacey, G. J.; Benford, D. J.; Staguhn, J. G.

    2010-01-01

    We have made the first detections of the 88 micrometers [O(sub III)] line from galaxies in the early universe, detecting the line from the lensed active galactic nucleus (AGN)/starburst composite systems APM 08279+5255 at z 3.911 and SMM J02399-0136 at z = 2.8076. The line is exceptionally bright from both systems, with apparent (lensed) luminosities approx.10(exp 11) Solar Luminosity, For APM 08279, the [O(sub III)] line flux can be modeled in a star formation paradigm, with the stellar radiation field dominated by stars with effective temperatures, T(sub eff) > 36,000 K, similar to the starburst found in M82. The model implies approx.35% of the total far-IR luminosity of the system is generated by the starburst, with the remainder arising from dust heated by the AGN. The 881,tm line can also be generated in the narrow-line region of the AGN if gas densities are around a few 1000 cu cm. For SMM J02399, the [O(sub III)] line likely arises from HII regions formed by hot (T(sub eff) > 40,000 K) young stars in a massive starburst that dominates the far-IR luminosity of the system. The present work demonstrates the utility of the [O(sub III)] line for characterizing starbursts and AGN within galaxies in the early universe. These are the first detections of this astrophysically important line from galaxies beyond a redshift of 0.05.s

  1. First Detection of the [O III] 88 μm Line at High Redshifts: Characterizing the Starburst and Narrow-line Regions in Extreme Luminosity Systems

    NASA Astrophysics Data System (ADS)

    Ferkinhoff, C.; Hailey-Dunsheath, S.; Nikola, T.; Parshley, S. C.; Stacey, G. J.; Benford, D. J.; Staguhn, J. G.

    2010-05-01

    We have made the first detections of the 88 μm [O III] line from galaxies in the early universe, detecting the line from the lensed active galactic nucleus (AGN)/starburst composite systems APM 08279+5255 at z = 3.911 and SMM J02399-0136 at z = 2.8076. The line is exceptionally bright from both systems, with apparent (lensed) luminosities ~1011 L sun. For APM 08279, the [O III] line flux can be modeled in a star formation paradigm, with the stellar radiation field dominated by stars with effective temperatures, T eff > 36,000 K, similar to the starburst found in M82. The model implies ~35% of the total far-IR luminosity of the system is generated by the starburst, with the remainder arising from dust heated by the AGN. The 88 μm line can also be generated in the narrow-line region of the AGN if gas densities are around a few 1000 cm-3. For SMM J02399, the [O III] line likely arises from H II regions formed by hot (T eff > 40,000 K) young stars in a massive starburst that dominates the far-IR luminosity of the system. The present work demonstrates the utility of the [O III] line for characterizing starbursts and AGN within galaxies in the early universe. These are the first detections of this astrophysically important line from galaxies beyond a redshift of 0.05.

  2. Simulations of the LHC high luminosity monitors at beam energies from 3.5 TeV to 7.0 TeV

    SciTech Connect

    Matis, H.S.; Miyamoto, R.; Humphreys, P.; Ratti, A.; Turner, W.C.; Stiller, J.

    2011-03-28

    We have constructed two pairs of fast ionization chambers (BRAN) for measurement and optimization of luminosity at IR1 and IR5 of the LHC. These devices are capable of monitoring the performance of the LHC at low luminosity 10{sup 28} cm{sup -2}s{sup -1} during beam commissioning all the way up to the expected full luminosity of 10{sup 34} cm{sup -2}s{sup -1} at 7.0 TeV. The ionization chambers measure the intensity of hadronic/electromagnetic showers produced by the forward neutral particles of LHC collisions. To predict and improve the understanding of the BRAN performance, we created a detailed FLUKA model of the detector and its surroundings. In this paper, we describe the model and the results of our simulations including the detector's estimated response to pp collisions at beam energies of 3.5, 5.0, and 7.0 TeV per beam. In addition, these simulations show the sensitivity of the BRAN to the crossing angle of the two LHC beams. It is shown that the BRAN sensitivity to the crossing angle is proportional to the measurement of crossing angle by the LHC beam position monitors.

  3. Effect of Insertion of a Heat Flux Gage into a High Temperature Cylindrical Blackbody Cavity on the Gage

    NASA Technical Reports Server (NTRS)

    Abdelmessih, Amanie N.; Horn, Thomas J.

    2007-01-01

    Detailed transient thermal models have been developed to simulate a heat flux gage calibration process capable of generating high heat flux levels. These heat flux levels are of interest to the reciprocating and gas turbine engine industries as well as the aerospace industry. The transient models are based on existing, experimentally validated steady state models of a cylindrical blackbody calibration system. The steady state models were modified to include insertion of a heat flux gage into the hot zone of the calibration system, time-varying electrical current that passes through the resistance heated blackbody, and the resulting heating of the heat flux gage. Heat fluxes computed using detailed transient models were compared to experimental measurements. The calculated and measured transient heat fluxes agreed to within 2 percent, indicating that the models had captured the physical phenomena in the transient calibration. The predicted and measured transient heat fluxes were also compared for two different blackbody configurations. The effect of convection on the blackbody extension was evaluated and found to be a minor factor.

  4. Effect of Insertion of a Heat Flux Gage into a High Temperature Cylindrical Blackbody Cavity on the Gage

    NASA Technical Reports Server (NTRS)

    Abdelmessih, Amanie N.; Horn, Thomas J.

    2007-01-01

    Detailed transient thermal models have been developed to simulate a heat flux gage calibration process capable of generating high heat flux levels. These heat flux levels are of interest to the reciprocating and gas turbine engine industries as well as the aerospace industry. The transient models are based on existing, experimentally validated steady state models of a cylindrical blackbody calibration system. The steady state models were modified to include insertion of a heat flux gage into the hot zone of the calibration system, time-varying electrical current that passes through the resistance heated blackbody, and the resulting heating of the heat flux gage. Heat fluxes computed using detailed transient models were compared to experimental measurements. The calculated and measured transient heat fluxes agreed to within 2 percent, indicating that the models had captured the physical phenomena in the transient calibration. The predicted and measured transient heat fluxes were also compared for two different blackbody configurations. The effect of convection on the blackbody extension was evaluated and found to be a minor factor.

  5. High-Quality Perovskite Films Grown with a Fast Solvent-Assisted Molecule Inserting Strategy for Highly Efficient and Stable Solar Cells.

    PubMed

    Yuan, Shuai; Qiu, Zhiwen; Gao, Chaomin; Zhang, Hailiang; Jiang, Yanan; Li, Cuncheng; Yu, Jinghua; Cao, Bingqiang

    2016-08-31

    The performance of organolead halide perovskites based solar cells has been enhanced dramatically due to the morphology control of the perovskite films. In this paper, we present a fast solvent-assisted molecule inserting (S-AMI) strategy to grow high-quality perovskite film, in which the methylammonium iodide/2-propanol (MAI/IPA) solution is spin-coated onto a dimethylformamide (DMF) wetted mixed lead halide (PbX2) precursor film. The DMF can help the inserting of MAI molecules into the PbX2 precursor film and provide a solvent environment to help the grain growth of the perovskite film. The perovskite film grown by the S-AMI approach shows large and well-oriented grains and long carrier lifetime due to the reduced grain boundary. Solar cells constructed with these perovskite films yield an average efficiency over 17% along with a high average fill factor of 80%. Moreover, these unsealed solar cell devices exhibit good stability in an ambient atmosphere.

  6. RHIC PLANS TOWARDS HIGHER LUMINOSITY

    SciTech Connect

    FEDOTOV,A.

    2007-06-25

    The Relativistic Heavy Ion Collider (RHIC) is designed to provide luminosity over a wide range of beam energies and species, including heavy ions, polarized protons, and tric beam collisions. In the first seven years of operation there has been a rapid increase in the achieved peak and average luminosity, substantially exceeding design values. Work is presently underway to achieve the Enhanced Design parameters. Planned major upgrades include the Electron Beam Ion Source (EBIS), RHIC-11, and construction of an electron-ion collider (eRHIC). We review the expected RHIC upgrade performance. Electron cooling and its impact on the luminosity both for heavy ions and protons are discussed in detail.

  7. [Management of High-Risk Prostate Cancer and Left Ectopic Ureter Inserting into Seminal Vesicle with Ipsilateral Hypoplastic Kidney of a Young Patient : A Case Report].

    PubMed

    Matsumoto, Teppei; Koie, Takuya; Soma, Osamu; Kusaka, Ayumu; Hosogoe, Shogo; Hamano, Itsuto; Imai, Atsushi; Hatakeyama, Shingo; Yoneyama, Takahiro; Hashimoto, Yasuhiro; Ohyama, Chikara

    2016-06-01

    A 44-year-old male patient visited our hospital with a chief complaint of macroscopic hematuria. Prostate biopsies were performed due to prostate specific antigen (PSA) 11.6 ng/ml, and he was diagnosed with Gleason score 5+4 prostate cancer. Computed tomography showed a left hypoplastic kidney. T2- weighted magnetic resonance imaging showed the left ureter stump with ectopic insertion into the dilated left seminal vesicle. He was diagnosed with high-risk prostate cancer and left ectopic ureter inserting into the seminal vesicle with ipsilateral hypoplastic kidney. Laparoscopic left nephroureterectomy and open radical prostatectomy were performed.

  8. Extremely high fracture rate of a modular acetabular component with a sandwich polyethylene ceramic insertion for THA: a preliminary report.

    PubMed

    Kircher, Jörn; Bader, Rainer; Schroeder, Bettina; Mittelmeier, Wolfram

    2009-09-01

    Improvements of ceramic components and design changes have reduced failure rates over the past 30 years in total hip arthroplasty. We present a series of n = 11 cases with ceramic failure out of n = 113 implantations, from which n = 66 were ceramic-on-ceramic (n = 50 with ceramic insert with sandwich in polyethylene and n = 16 with directly fixed ceramic inlay) and n = 47 ceramic on polyethylene bearings, between 1999 and 2001 after introduction of a new implantation system to the market. The overall fracture rate of ceramic for the whole series (n = 113) was 9.7%. For the combination ceramic head with UHMW-PE (n = 47) the fracture rate was 2.1%. For the combination ceramic with ceramic (n = 66) the fracture rate was 15.2%. For the combination ceramic with ceramic sandwich in PE (n = 50) the failure rate was 18%. Only three patients experienced a trauma. Demography of patients (age, gender, body weight and BMI) was not statistically different between patients with failed ceramics and the rest of the patients making patient-specific risk factors unlikely to be an explanation for the failures. Retrospective X-ray analysis of the cup positioning did not show significant difference between failed and non-failed implants in terms of mean cup inclination and version making also operation-specific factors unlikely to be the only reason of this high failure rate. Therefore, manufacturer-specific factors such as design features may have contributed to this high failure rate. Further analysis of the whole series with biomechanical testing of the retrieved material needs to be performed.

  9. Support Structure Design of the $\\hbox{Nb}_{3}\\hbox{Sn}$ Quadrupole for the High Luminosity LHC

    SciTech Connect

    Juchno, M.; Ambrosio, G.; Anerella, M.; Cheng, D.; Felice, H.; Ferracin, P.; Perez, J. C.; Prin, H.; Schmalzle, J.

    2014-10-31

    New low-β quadrupole magnets are being developed within the scope of the High Luminosity LHC (HL-LHC) project in collaboration with the US LARP program. The aim of the HLLHC project is to study and implement machine upgrades necessary for increasing the luminosity of the LHC. The new quadrupoles, which are based on the Nb₃Sn superconducting technology, will be installed in the LHC Interaction Regions and will have to generate a gradient of 140 T/m in a coil aperture of 150 mm. In this paper, we describe the design of the short model magnet support structure and discuss results of the detailed 3D numerical analysis performed in preparation for the first short model test.

  10. Mechanisms for Complex Chromosomal Insertions

    PubMed Central

    Szafranski, Przemyslaw; Akdemir, Zeynep Coban; Yuan, Bo; Cooper, Mitchell L.; Magriñá, Maria A.; Bacino, Carlos A.; Lalani, Seema R.; Patel, Ankita; Song, Rodger H.; Bi, Weimin; Cheung, Sau Wai; Carvalho, Claudia M. B.; Lupski, James R.

    2016-01-01

    Chromosomal insertions are genomic rearrangements with a chromosome segment inserted into a non-homologous chromosome or a non-adjacent locus on the same chromosome or the other homologue, constituting ~2% of nonrecurrent copy-number gains. Little is known about the molecular mechanisms of their formation. We identified 16 individuals with complex insertions among 56,000 individuals tested at Baylor Genetics using clinical array comparative genomic hybridization (aCGH) and fluorescence in situ hybridization (FISH). Custom high-density aCGH was performed on 10 individuals with available DNA, and breakpoint junctions were fine-mapped at nucleotide resolution by long-range PCR and DNA sequencing in 6 individuals to glean insights into potential mechanisms of formation. We observed microhomologies and templated insertions at the breakpoint junctions, resembling the breakpoint junction signatures found in complex genomic rearrangements generated by replication-based mechanism(s) with iterative template switches. In addition, we analyzed 5 families with apparently balanced insertion in one parent detected by FISH analysis and found that 3 parents had additional small copy-number variants (CNVs) at one or both sides of the inserting fragments as well as at the inserted sites. We propose that replicative repair can result in interchromosomal complex insertions generated through chromothripsis-like chromoanasynthesis involving two or three chromosomes, and cause a significant fraction of apparently balanced insertions harboring small flanking CNVs. PMID:27880765

  11. Mechanisms for Complex Chromosomal Insertions.

    PubMed

    Gu, Shen; Szafranski, Przemyslaw; Akdemir, Zeynep Coban; Yuan, Bo; Cooper, Mitchell L; Magriñá, Maria A; Bacino, Carlos A; Lalani, Seema R; Breman, Amy M; Smith, Janice L; Patel, Ankita; Song, Rodger H; Bi, Weimin; Cheung, Sau Wai; Carvalho, Claudia M B; Stankiewicz, Paweł; Lupski, James R

    2016-11-01

    Chromosomal insertions are genomic rearrangements with a chromosome segment inserted into a non-homologous chromosome or a non-adjacent locus on the same chromosome or the other homologue, constituting ~2% of nonrecurrent copy-number gains. Little is known about the molecular mechanisms of their formation. We identified 16 individuals with complex insertions among 56,000 individuals tested at Baylor Genetics using clinical array comparative genomic hybridization (aCGH) and fluorescence in situ hybridization (FISH). Custom high-density aCGH was performed on 10 individuals with available DNA, and breakpoint junctions were fine-mapped at nucleotide resolution by long-range PCR and DNA sequencing in 6 individuals to glean insights into potential mechanisms of formation. We observed microhomologies and templated insertions at the breakpoint junctions, resembling the breakpoint junction signatures found in complex genomic rearrangements generated by replication-based mechanism(s) with iterative template switches. In addition, we analyzed 5 families with apparently balanced insertion in one parent detected by FISH analysis and found that 3 parents had additional small copy-number variants (CNVs) at one or both sides of the inserting fragments as well as at the inserted sites. We propose that replicative repair can result in interchromosomal complex insertions generated through chromothripsis-like chromoanasynthesis involving two or three chromosomes, and cause a significant fraction of apparently balanced insertions harboring small flanking CNVs.

  12. A Survey of Luminous High-redshift Quasars with SDSS and WISE. II. the Bright End of the Quasar Luminosity Function at z ≈ 5

    NASA Astrophysics Data System (ADS)

    Yang, Jinyi; Wang, Feige; Wu, Xue-Bing; Fan, Xiaohui; McGreer, Ian D.; Bian, Fuyan; Yi, Weimin; Yang, Qian; Ai, Yanli; Dong, Xiaoyi; Zuo, Wenwen; Green, Richard; Jiang, Linhua; Wang, Shu; Wang, Ran; Yue, Minghao

    2016-09-01

    This is the second paper in a series on a new luminous z ˜ 5 quasar survey using optical and near-infrared colors. Here we present a new determination of the bright end of the quasar luminosity function (QLF) at z ˜ 5. Combining our 45 new quasars with previously known quasars that satisfy our selections, we construct the largest uniform luminous z ˜ 5 quasar sample to date, with 99 quasars in the range of 4.7 ≤ z < 5.4 and -29 < M 1450 ≤ -26.8, within the Sloan Digital Sky Survey (SDSS) footprint. We use a modified 1/V a method including flux limit correction to derive a binned QLF, and we model the parametric QLF using maximum likelihood estimation. With the faint-end slope of the QLF fixed as α = -2.03 from previous deeper samples, the best fit of our QLF gives a flatter bright end slope β = -3.58 ± 0.24 and a fainter break magnitude {M}1450* = -26.98 ± 0.23 than previous studies at similar redshift. Combined with previous work at lower and higher redshifts, our result is consistent with a luminosity evolution and density evolution model. Using the best-fit QLF, the contribution of quasars to the ionizing background at z ˜ 5 is found to be 18%-45% with a clumping factor C of 2-5. Our sample suggests an evolution of radio loud fraction with optical luminosity but no obvious evolution with redshift.

  13. Rhodium(I)-Catalyzed Highly Enantioselective Insertion of Carbenoid into Si-H: Efficient Access to Functional Chiral Silanes.

    PubMed

    Chen, Diao; Zhu, Dong-Xing; Xu, Ming-Hua

    2016-02-10

    The first rhodium(I)-catalyzed enantioselective Si-H insertion reaction of α-diazoesters and α-diazophosphonates has been developed. The use of a C1-symmetric chiral diene ligand enabled the asymmetric reaction to proceed under exceptionally mild conditions and give versatile chiral α-silyl esters and phosphonates with excellent enantioselectivities (up to 99% ee). The mechanism and stereochemical pathway of this novel Rh(I)-carbene-directed Si-H insertion was investigated by deuterium kinetic isotope effect experiments and DFT calculations.

  14. High thermal stability in W/MgO/CoFeB/W/CoFeB/W stacks via ultrathin W insertion with perpendicular magnetic anisotropy

    NASA Astrophysics Data System (ADS)

    Liu, Yi; Yu, Tao; Zhu, Zhengyong; Zhong, Huicai; Khamis, Khamis Masoud; Zhu, Kaigui

    2016-07-01

    The perpendicular magnetic anisotropy (PMA) of a series of top MgO/CoFeB/W stacks were studied. In these stacks, the thickness of CoFeB is limited in a range of 1.1-2.2 nm. It was found that the stack can still maintain PMA in a 1.9 nm thick CoFeB free layer. Besides, we investigated the thermal stability factor ∆ of a spin transfer torque magnetic random access memory (STT-MRAM) by inserting an ultra-thin W film of 0.8 nm between two CoFeB films. The result shows a clear PMA behavior for the samples with CoFeB thickness up to 2.5 nm, and an in-plane magnetic anisotropy (IMA) when the CoFeB is thicker than 2.5 nm. Moreover, the thermal stability factor ∆ of the CoFeB stack with W insertion is about 132 for a 50 nm size STT-MRAM device, which is remarkably improved compared to 112 for a sample without W insertion. Our results represent an alternative way to realize the endurance at high annealing temperature, high-density and high ∆ in STT-MRAM device by ultra-thin W insertion.

  15. Ion bunch length effects on the beam-beam interaction and its compensation in a high-luminosity ring-ring electron-ion collider

    SciTech Connect

    Montag C.; Oeftiger, A.; Fischer, W.

    2012-05-20

    One of the luminosity limits in a ring-ring electron-ion collider is the beam-beam effect on the electrons. In the limit of short ion bunches, simulation studies have shown that this limit can be significantly increased by head-on beam-beam compensation with an electron lens. However, with an ion bunch length comparable to the beta-function at the IP in conjunction with a large beam-beam parameter, the electrons perform a sizeable fraction of a betatron oscillation period inside the long ion bunches. We present recent simulation results on the compensation of this beam-beam interaction with multiple electron lenses.

  16. Chest tube insertion

    MedlinePlus

    Chest drainage tube insertion; Insertion of tube into chest; Tube thoracostomy; Pericardial drain ... When your chest tube is inserted, you will lie on your side or sit partly upright, with one arm over your head. Sometimes, ...

  17. Dihalocarbene Insertion Experiment

    ERIC Educational Resources Information Center

    Goh, S. H.

    1975-01-01

    Describes the insertion reaction using the insertion of carbenes into carbon-hydrogen bonds as an example. Outlines an experiment that will illustrate dihalocarbene insertions into diisopropyl ether. (GS)

  18. BOSS Great Wall: morphology, luminosity, and mass

    NASA Astrophysics Data System (ADS)

    Einasto, Maret; Lietzen, Heidi; Gramann, Mirt; Saar, Enn; Tempel, Elmo; Liivamägi, Lauri Juhan; Montero-Dorta, Antonio D.; Streblyanska, Alina; Maraston, Claudia; Rubiño-Martín, José Alberto

    2017-06-01

    Context. Galaxy superclusters are the largest systems in the Universe that can give us information about the formation and evolution of the cosmic web. Aims: We study the morphology of the superclusters from the BOSS Great Wall (BGW), a recently discovered very rich supercluster complex at the redshift z = 0.47. Methods: We have employed the Minkowski functionals to quantify supercluster morphology. We calculate supercluster luminosities and masses using two methods. Firstly, we used data about the luminosities and stellar masses of high stellar mass galaxies with log (M∗/h-1M⊙) ≥ 11.3. Secondly, we applied a scaling relation that combines morphological and physical parameters of superclusters to obtain supercluster luminosities, and obtained supercluster masses using the mass-to-light ratios found for local rich superclusters. Results: The BGW superclusters are very elongated systems, with shape parameter values of less than 0.2. This value is lower than that found for the most elongated local superclusters. The values of the fourth Minkowski functional V3 for the richer BGW superclusters (V3 = 7 and 10) show that they have a complicated and rich inner structure. We identify two Planck SZ clusters in the BGW superclusters, one in the richest BGW supercluster, and another in one of the poor BGW superclusters. The luminosities of the BGW superclusters are in the range of 1-8 × 1013h-2L⊙, and masses in the range of 0.4-2.1 × 1016h-1M⊙. Supercluster luminosities and masses obtained with two methods agree well. Conclusions: The BGW is a complex of massive, luminous and large superclusters with very elongated shape. The search and detailed study, including the morphology analysis of the richest superclusters and their complexes from observations and simulations can help us to understand formation and evolution of the cosmic web.

  19. Inserted layer of AZO thin film with high work function between transparent conductive oxide and p-layer and its solar cell application.

    PubMed

    Park, Hyeongsik; Lee, Jaehyeong; Lee, Youn-Jung; Kim, Heewon; Jung, Junhee; Hussain, S Qamar; Park, Jinjoo; Shin, Chonghoon; Kim, Sunbo; Ahn, Shihyun; Yil, Junsin

    2013-10-01

    We report aluminum doped zinc oxide (AZO) films with high work function as an insertion layer between transparent conducting oxides (TCO) and hydrogenated amorphous silicon carbide (a-SiC:H) layer to improve open circuit voltage (V(oc)) and fill factor (FF) for thin film solar cells. Amorphous silicon (a-Si:H) solar cells exhibit poor fill factors due to a Schottky barrier at the interface between a-SiC:H window and TCO. The interface engineering is carried out by inserting an AZO layer with high work function (4.95 eV at O2 = 2 sccm). As a result, V(oc) and FF improved significantly. FF as high as 63.35% is obtained.

  20. Wear Mechanism of Chemical Vapor Deposition (CVD) Carbide Insert in Orthogonal Cutting Ti-6Al-4V ELI at High Cutting Speed

    SciTech Connect

    Gusri, A. I.; Che Hassan, C. H.; Jaharah, A. G.

    2011-01-17

    The performance of Chemical Vapor Deposition (CVD) carbide insert with ISO designation of CCMT 12 04 04 LF, when turning titanium alloys was investigated. There were four layers of coating materials for this insert i.e.TiN-Al2O3-TiCN-TiN. The insert performance was evaluated based on the insert's edge resistant towards the machining parameters used at high cutting speed range of machining Ti-6Al-4V ELI. Detailed study on the wear mechanism at the cutting edge of CVD carbide tools was carried out at cutting speed of 55-95 m/min, feed rate of 0.15-0.35 mm/rev and depth of cut of 0.10-0.20 mm. Wear mechanisms such as abrasive and adhesive were observed on the flank face. Crater wear due to diffusion was also observed on the rake race. The abrasive wear occurred more at nose radius and the fracture on tool were found at the feed rate of 0.35 mm/rev and the depth of cut of 0.20 mm. The adhesion wear takes place after the removal of the coating or coating delaminating. Therefore, adhesion or welding of titanium alloy onto the flank and rake faces demonstrates a strong bond at the workpiece-tool interface.

  1. Second-generation coil design of the Nb3Sn low-β quadrupole for the high luminosity LHC

    SciTech Connect

    Bermudez, S. Izquierdo; Ambrosio, G.; Ballarino, A.; Cavanna, E.; Bossert, R.; Cheng, D.; Dietderich, D.; Ferracin, P.; Ghosh, A.; Hagen, P.; Holik, E.; Perez, J. C.; Rochepault, E.; Schmalzle, J.; Todesco, E.; Yu, M.

    2016-01-18

    As part of the Large Hadron Collider Luminosity upgrade (HiLumi-LHC) program, the US LARP collaboration and CERN are working together to design and build a 150 mm aperture Nb3Sn quadrupole for the LHC interaction regions. A first series of 1.5 m long coils were fabricated and assembled in a first short model. A detailed visual inspection of the coils was carried out to investigate cable dimensional changes during heat treatment and the position of the windings in the coil straight section and in the end region. The analyses allow identifying a set of design changes which, combined with a fine tune of the cable geometry and a field quality optimization, were implemented in a new, second-generation, coil design. In this study, we review the main characteristics of the first generation coils, describe the modification in coil lay-out, and discuss their impact on parts design and magnet analysis.

  2. A complete X-ray sample of the high latitude sky from HEAO-1 A-2: log N lo S and luminosity functions

    NASA Technical Reports Server (NTRS)

    Piccinotti, G.; Mushotzky, R. F.; Boldt, E. A.; Holt, S. S.; Marshall, F. E.; Serlemitsos, P. J.; Shafer, R. A.

    1981-01-01

    An experiment was performed in which a complete X-ray survey of the 8.2 steradians of the sky at galactic latitudes where the absolute value of b is 20 deg down to a limiting sensitivity of 3.1 x ten to the minus 11th power ergs/sq cm sec in the 2-10 keV band. Of the 85 detected sources 17 were identified with galactic objects, 61 were identified with extragalactic objects, and 7 remain unidentified. The log N - log S relation for the non-galactic objects is well fit by the Euclidean relationship. The X-ray spectra of these objects were used to construct log N - log S in physical units. The complete sample of identified sources was used to construct X-ray luminosity functions, using the absolute maximum likelihood method, for clusters galaxies and active galactic nuclei.

  3. CoFeB Inserted Perpendicular Magnetic Tunnel Junctions with CoFe/Pd Multilayers for High Tunnel Magnetoresistance Ratio

    NASA Astrophysics Data System (ADS)

    Mizunuma, Kotaro; Ikeda, Shoji; Yamamoto, Hiroyuki; Gan, Hua Dong; Miura, Katsuya; Hasegawa, Haruhiro; Hayakawa, Jun; Ito, Kenchi; Matsukura, Fumihiro; Ohno, Hideo

    2010-04-01

    The effect of Co20Fe60B20 insertion on tunnel magnetoresistance (TMR) properties of MgO barrier magnetic tunnel junctions (MTJs) was studied with Co90Fe10/Pd multilayer electrodes showing perpendicular anisotropy. The TMR ratio, which depended on the sputtering power density of the CoFeB layer, reached 43% at 1.77 W/cm2 in MTJs with a 1.8-nm-thick CoFeB layer inserted on both sides of the MgO barrier. With increasing CoFeB layer thickness, the optimal annealing temperature (Ta) realizing the maximum TMR ratio increased along with the TMR ratio. The MTJs with 3.0-nm-thick CoFeB deposited at 1.77 W/cm2 showed a TMR ratio of 91% at Ta = 250 °C, where the perpendicular magnetic anisotropy is maintained.

  4. Supermassive Black Holes with High Accretion Rates in Active Galactic Nuclei. V. A New Size-Luminosity Scaling Relation for the Broad-line Region

    NASA Astrophysics Data System (ADS)

    Du, Pu; Lu, Kai-Xing; Zhang, Zhi-Xiang; Huang, Ying-Ke; Wang, Kai; Hu, Chen; Qiu, Jie; Li, Yan-Rong; Fan, Xu-Liang; Fang, Xiang-Er; Bai, Jin-Ming; Bian, Wei-Hao; Yuan, Ye-Fei; Ho, Luis C.; Wang, Jian-Min; SEAMBH Collaboration

    2016-07-01

    This paper reports results of the third-year campaign of monitoring super-Eddington accreting massive black holes (SEAMBHs) in active galactic nuclei (AGNs) between 2014 and 2015. Ten new targets were selected from the quasar sample of the Sloan Digital Sky Survey (SDSS), which have generally been more luminous than the SEAMBH candidates in the last two years. Hβ lags ({τ }{{H}β }) in five of the 10 quasars have been successfully measured in this monitoring season. We find that the lags are generally shorter, by large factors, than those of objects with same optical luminosity, in light of the well-known R H β-L 5100 relation. The five quasars have dimensionless accretion rates of \\dot{{M}\\quad }=10-103. Combining these with measurements of the previous SEAMBHs, we find that the reduction of Hβ lags depends tightly on accretion rates, {τ }{{H}β }/{τ }R-L\\propto {\\dot{{M}}}-0.42, where {τ }R-L is the Hβ lag from the normal R H β-L 5100 relation. Fitting 63 mapped AGNs, we present a new scaling relation for the broad-line region: {R}{{H}β }={α }1{{\\ell }}44{β 1} {min} [1,{(\\dot{{M}}/{\\dot{{M}}}c)}-{γ 1}], where {{\\ell }}44={L}5100/{10}44 {erg} {{{s}}}-1 is the 5100 Å continuum luminosity, and the coefficients are {α }1={29.6}-2.8+2.7 lt-day, {β }1={0.56}-0.03+0.03, {γ }1={0.52}-0.16+0.33, and {\\dot{{M}}}c={11.19}-6.22+2.29. This relation is applicable to AGNs over a wide range of accretion rates, from 10-3 to 103. Implications of this new relation are briefly discussed.

  5. Modified C1 lateral mass screw insertion using a high entry point to avoid postoperative occipital neuralgia.

    PubMed

    Lee, Sun-Ho; Kim, Eun-Sang; Eoh, Whan

    2013-01-01

    For the past decade, a screw-rod construct has been used commonly to stabilize the atlantoaxial joint, but the insertion of the screw through the C1 lateral mass (LM) can cause several complications. We evaluated whether using a higher screw entry point for C1 lateral mass (LM) fixation than in the standard procedure could prevent screw-induced occipital neuralgia. We enrolled 12 consecutive patients who underwent bilateral C1 LM fixation, with the modified screw insertion point at the junction of the C1 posterior arch and the midpoint of the posterior inferior portion of the C1 LM. We measured postoperative clinical and radiological parameters and recorded intraoperative complications, postoperative neurological deficits and the occurrence of occipital neuralgia. Postoperative plain radiographs were used to check for malpositioning of the screw or failure of the construct. Four patients underwent atlantoaxial stabilization for a transverse ligament injury or a C1 or C2 fracture, six patients for os odontoideum, and two patients for C2 metastasis. No patient experienced vertebral artery injury or cerebrospinal fluid leak, and all had minimal blood loss. No patient suffered significant occipital neuralgia, although one patient developed mild, transient unilateral neuralgia. There was also no radiographic evidence of construct failure. Twenty screws were positioned correctly through the intended entry points, but three screws were placed inferiorly (that is, below the arch), and one screw was inserted too medially. When performing C1-C2 fixation using the standard (Harms) construct, surgeons should be aware of the possible development of occipital neuralgia. A higher entry point may prevent this complication; therefore, we recommend that the screw should be inserted into the arch of C1 if it can be accommodated. Copyright © 2012 Elsevier Ltd. All rights reserved.

  6. Multiwavelength Luminosity Functions of Galaxies

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan; Oegerle, William R. (Technical Monitor)

    2002-01-01

    I have developed a technique for measuring multi-variate luminosity functions of galaxies. Multivariate or multi-wavelength luminosity functions will reveal the interplay between star formation, chemical evolution, and absorption and re-emission of dust within evolving galaxy populations. By using principle component analysis to reduce the dimensionality of the problem, I optimally extract the relevant photometric information from large galaxy catalogs. As a demonstration of the technique, I derive the multiwavelength luminosity function for the galaxies in the released SDSS catalog, and show that the results are consistent with those obtained by traditional methods. This technique will be applicable to catalogs of galaxies from datasets obtained by the SIRTF and GALEX missions.

  7. AMMONIA AND CO OBSERVATIONS TOWARD LOW-LUMINOSITY 6.7 GHz METHANOL MASERS

    SciTech Connect

    Wu, Y. W.; Xu, Y.; Yang, J.; Zhang, S. B.; Pandian, J. D.; Henkel, C.; Menten, K. M.

    2010-09-01

    To investigate whether distinctions exist between low- and high-luminosity Class II 6.7 GHz methanol masers, we have undertaken multi-line mapping observations of various molecular lines, including the NH{sub 3} (1,1), (2,2), (3,3), (4,4), and {sup 12}CO (1-0) transitions, toward a sample of nine low-luminosity 6.7 GHz masers and {sup 12}CO (1-0) observations toward a sample of eight high-luminosity 6.7 GHz masers, for which we already had NH{sub 3} spectral line data. Emission in the NH{sub 3} (1,1), (2,2), and (3,3) transitions was detected in eight out of nine low-luminosity maser sources, in which 14 cores were identified. We derive densities, column densities, temperatures, core sizes, and masses of both low- and high-luminosity maser regions. A comparative analysis of the physical quantities reveals marked distinctions between the low-luminosity and high-luminosity groups: in general, cores associated with high-luminosity 6.7 GHz masers are larger and more massive than those traced by low-luminosity 6.7 GHz masers; regions traced by the high-luminosity masers have larger column densities but lower densities than those of the low-luminosity maser regions. Further, strong correlations between 6.7 GHz maser luminosity and NH{sub 3} (1,1) and (2,2) line widths are found, indicating that internal motions in high-luminosity maser regions are more energetic than those in low-luminosity maser regions. A {sup 12}CO (1-0) outflow analysis also shows distinctions in that outflows associated with high-luminosity masers have wider line wings and larger sizes than those associated with low-luminosity masers.

  8. Evolutionary variations of solar luminosity

    NASA Technical Reports Server (NTRS)

    Endal, A. S.

    1981-01-01

    Theoretical arguments for a 30% increase in the solar luminosity over the past 4.7 billion years are reviewed. A scaling argument shows that this increase can be predicted without detailed numerical calculations. The magnitude of the increase is independent of nuclear reaction rates, as long as conversion of hydrogen to helium provides the basic energy source of the Sun. The effect of the solar luminosity increase on the terrestrial climate is briefly considered. It appears unlikely that an enhanced greenhouse effect, due to reduced gases (NH3, CH4), can account for the long-term paleoclimatic trends.

  9. The faint quasar luminosity function

    NASA Technical Reports Server (NTRS)

    Kron, Richard G.; Bershady, Matthew A.; Munn, Jeffrey A.; Smetanka, John J.; Majewski, Steven; Koo, David C.

    1991-01-01

    Preliminary results of an expanded program to determine the faint-quasar luminosity function are described. Quasars have been selected in four fields totaling 1.2 sq deg from four-band photometry. Out of a total of 130 quasars with good spectroscopy, 37 have J greater than 21.5 and 46 have F greater than 21.0. The spectroscopic sample is representative of all of the color-selected candidates. An estimate of the luminosity function as a function of redshift is derived.

  10. UPGRADING RHIC FOR HIGHER LUMINOSITY.

    SciTech Connect

    MACKAY,W.; BEN-ZVI,I.; BRENNAN,J.M.; HARRISON,M.; KEWISCH,J.; PEGGS,S.; ROSER,T.; TRBOJEVIC,D.; PARKHOMCHUK,V.

    2001-06-18

    While RHIC has only just started running for its heavy ion physics program, in the first run last summer, we achieved 10% of the design luminosity. In this paper we discuss plans for increasing the luminosity by a factor of 35 beyond the nominal design. A factor of 4 should be straightforward by doubling the number of bunches per ring and squeezing the {beta}* from 2 to 1 m at selected interaction points. An additional factor of 8 to 10 could be possible by using electron cooling to counteract intrabeam scattering and reduce emittances of the beams.

  11. Diamond Pixel Luminosity Telescopes

    SciTech Connect

    Halyo, Valerie

    2014-12-15

    In this document, Halyo summaries her key contributions to CMS at the LHC and provide an explanation of their importance and her role in each project. At the end Halyo describes her recent research interest that includes GPU/MIC Acceleration of the High Level Trigger (HLT) to Extend the Physics Research at the LHC. A description of her work the recent promising results that she accomplished and the deliverable are also elaborated. These contribution were only possible thanks to DOE support of junior faculty research and their clear goal to promote research and innovations.

  12. Voltage-programming-based capillary gel electrophoresis for the fast detection of angiotensin-converting enzyme insertion/deletion polymorphism with high sensitivity.

    PubMed

    Woo, Nain; Kim, Su-Kang; Kang, Seong Ho

    2016-08-01

    A voltage-programming-based capillary gel electrophoresis method with a laser-induced fluorescence detector was developed for the fast and highly sensitive detection of DNA molecules related to angiotensin-converting enzyme insertion/deletion polymorphism, which has been reported to influence predisposition to various diseases such as cardiovascular disease, high blood pressure, myocardial infarction, and Alzheimer's disease. Various voltage programs were investigated for fast detection of specific DNA molecules of angiotensin-converting enzyme insertion/deletion polymorphism as a function of migration time and separation efficiency to establish the effect of voltage strength to resolution. Finally, the amplified products of the angiotensin-converting enzyme insertion/deletion polymorphism (190 and 490 bp DNA) were analyzed in 3.2 min without losing resolution under optimum voltage programming conditions, which were at least 75 times faster than conventional slab gel electrophoresis. In addition, the capillary gel electrophoresis method also successfully applied to the analysis of real human blood samples, although no polymorphism genes were detected by slab gel electrophoresis. Consequently, the developed voltage-programming capillary gel electrophoresis method with laser-induced fluorescence detection is an effective, rapid analysis technique for highly sensitive detection of disease-related specific DNA molecules.

  13. The white dwarf luminosity function

    NASA Astrophysics Data System (ADS)

    García-Berro, Enrique; Oswalt, Terry D.

    2016-06-01

    White dwarfs are the final remnants of low- and intermediate-mass stars. Their evolution is essentially a cooling process that lasts for ∼ 10 Gyr. Their observed properties provide information about the history of the Galaxy, its dark matter content and a host of other interesting astrophysical problems. Examples of these include an independent determination of the past history of the local star formation rate, identification of the objects responsible for the reported microlensing events, constraints on the rate of change of the gravitational constant, and upper limits to the mass of weakly interacting massive particles. To carry on these tasks the essential observational tools are the luminosity and mass functions of white dwarfs, whereas the theoretical tools are the evolutionary sequences of white dwarf progenitors, and the corresponding white dwarf cooling sequences. In particular, the observed white dwarf luminosity function is the key manifestation of the white dwarf cooling theory, although other relevant ingredients are needed to compare theory and observations. In this review we summarize the recent attempts to empirically determine the white dwarf luminosity function for the different Galactic populations. We also discuss the biases that may affect its interpretation. Finally, we elaborate on the theoretical ingredients needed to model the white dwarf luminosity function, paying special attention to the remaining uncertainties, and we comment on some applications of the white dwarf cooling theory. Astrophysical problems for which white dwarf stars may provide useful leverage in the near future are also discussed.

  14. Enhanced electrical properties of oxide semiconductor thin-film transistors with high conductivity thin layer insertion for the channel region

    NASA Astrophysics Data System (ADS)

    Nguyen, Cam Phu Thi; Raja, Jayapal; Kim, Sunbo; Jang, Kyungsoo; Le, Anh Huy Tuan; Lee, Youn-Jung; Yi, Junsin

    2017-02-01

    This study examined the performance and the stability of indium tin zinc oxide (ITZO) thin film transistors (TFTs) by inserting an ultra-thin indium tin oxide (ITO) layer at the active/insulator interface. The electrical properties of the double channel device (ITO thickness of 5 nm) were improved in comparison with the single channel ITZO or ITO devices. The TFT characteristics of the device with an ITO thickness of less than 5 nm were degraded due to the formation of an island-like morphology and the carriers scattering at the active/insulator interface. The 5 nm-thick ITO inserted ITZO TFTs (optimal condition) exhibited a superior field effect mobility (∼95 cm2/V·s) compared with the ITZO-only TFTs (∼34 cm2/V·s). The best characteristics of the TFT devices with double channel layer are due to the lowest surface roughness (0.14 nm) and contact angle (50.1°) that result in the highest hydrophicility, and the most effective adhesion at the surface. Furthermore, the threshold voltage shifts for the ITO/ITZO double layer device decreased to 0.80 and -2.39 V compared with 6.10 and -6.79 V (for the ITZO only device) under positive and negative bias stress, respectively. The falling rates of EA were 0.38 eV/V and 0.54 eV/V for the ITZO and ITO/ITZO bi-layer devices, respectively. The faster falling rate of the double channel devices suggests that the trap density, including interface trap and semiconductor bulk trap, can be decreased by the ion insertion of a very thin ITO film into the ITZO/SiO2 reference device. These results demonstrate that the double active layer TFT can potentially be applied to the flat panel display.

  15. Performance of a PET Insert for High Resolution Small Animal PET/MR Imaging at 7T.

    PubMed

    Stortz, Greg; Thiessen, Jonathan D; Bishop, Daryl; Khan, Muhammad S; Kozlowski, Piotr; Retière, Fabrice; Schellenberg, Graham; Shams, Ehsan; Zhang, Xuezhu; Thompson, Christopher J; Goertzen, Andrew; Sossi, Vesna

    2017-09-14

    We present the characterization of a compact magnetic resonance (MR) compatible positron emission tomography (PET) insert for simultaneous pre-clinical PET/MR imaging. While specifically designed with the strict size constraint to fit inside the 114 mm inner diameter of the BGA-12S gradient coil used in the Bruker 70/20 and 94/20 series of small animal MR imaging (MRI) systems, the insert can be easily installed in any appropriate MRI scanner or used as a stand-alone PET system. Methods: The insert is made from a ring of 16 detector-blocks each made from depth-of-interaction capable dual-layer-offset arrays of cerium-doped lutetium-yttrium oxyorthosilicate crystals read out by silicon photomultiplier (SiPM) arrays. Scintillator crystal arrays are made from 22×10 / 21×9 crystals in the bottom/top layers with 6/4 mm layer thicknesses, arranged with a 1.27 mm pitch, resulting in a useable field of view (FOV) 28 mm long and ~55 mm wide. Results: Spatial resolution ranges from 1.17 to 1.86 mm full-width-at-half-maximum (FWHM) in the radial direction from a radial offset of 0 to 15 mm. With a 300-800 keV energy window, peak sensitivity is 2.2% and noise-equivalent count rate (NECR) from a mouse-sized phantom at 3.7 MBq is 11.1 kcps and peaks at 20.8 kcps at 14.5 MBq. Phantom imaging shows that feature sizes as low as 0.7 mm can be resolved. (18)F-fluorodeoxyglucose ((18)F-FDG) PET/MR images of mouse and rat brains show no signs of inter-modality interference, and can excellently resolve substructures within the brains. Conclusion: Due to excellent spatial resolvability and lack of intermodality interference, this PET insert will serve as a useful tool for pre-clinical PET/MR. Copyright © 2017 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

  16. Dynamic and High-Resolution Metabolic Imaging of Hyperpolarized [1-13C]-Pyruvate in the Rat Brain Using a High-Performance Gradient Insert

    PubMed Central

    Mayer, Dirk; Yen, Yi-Fen; Takahashi, Atsushi; Josan, Sonal; Tropp, James; Rutt, B.K.; Hurd, Ralph E.; Spielman, Daniel M.; Pfefferbaum, Adolf

    2010-01-01

    Fast chemical shift imaging techniques are advantageous in metabolic imaging of hyperpolarized compounds due to the limited duration of the signal amplification. At the same time, reducing the acquisition time in hyperpolarized imaging does not necessarily lead to the conventional penalty in signal-to-noise ratio that occurs in imaging at thermal equilibrium polarization levels. Here a high-performance gradient insert was used in combination with undersampled spiral chemical shift imaging to increase either the imaging speed or the spatial resolution of hyperpolarized 13C metabolic imaging on a clinical 3T MR scanner. Both a single-shot sequence with a total acquisition time of 125 ms and a 3-shot sequence with a nominal in-plane resolution of 1.5 mm were implemented. The k-space trajectories were measured and then used during image reconstruction. The technique was applied to metabolic imaging of the rat brain in vivo after the injection of hyperpolarized [1-13C]-pyruvate. Dynamic imaging afforded the measurement of region-of-interest-specific time courses of pyruvate and its metabolic products, while imaging at high spatial resolution was used to better characterize the spatial distribution of the metabolite signals. PMID:21500253

  17. The ATLAS Insertable B-Layer (IBL) project

    NASA Astrophysics Data System (ADS)

    Bilbao de Mendizabal, J.

    2013-12-01

    Preparing for the high luminosity LHC phase, the ATLAS experiment will upgrade its Pixel Detector with the installation of a new pixel layer. The new sub detector, called the Insertable B-Layer (IBL), will be installed during the LHC first shut down in 2013-2014, in between the innermost current pixel layer and the beampipe. To cope with the high radiation and pixel occupancy due to the proximity to the interaction point, a new readout chip FE-I4 and two different silicon sensor technologies, planar and 3D have been developed. Furthermore, the physics performance should be improved through the reduction of pixel size and a new mechanical support using lightweight staves. Two pre-series staves were made in order to qualify the assembly procedure, the loaded module electrical integrity and the readout chain before going into production.

  18. Driving vertical phase separation in a bulk-heterojunction by inserting a poly(3-hexylthiophene) layer for highly efficient organic solar cells

    SciTech Connect

    Oh, Jin Young; Jang, Woo Soon; Lee, Tae Il; Myoung, Jae-Min; Baik, Hong Koo

    2011-01-10

    A desirable vertical phase separation of a bulk-heterojunction was achieved by inserting a P3HT layer between the blend layer and the poly(3,4-ethylenedioxythiophene) poly(styrenesulfonate) (PEDOT:PSS) layer. According to the high (PEDOT:PSS) and low (P3HT) surface energies of substrate, it might be possible to modulate the vertical phase separation in the bulk-heterojunction. The result of vertical phase separation was determined using time-of-flight secondary-ion mass spectroscopy analysis. A controlled thickness of 50 nm for the inserted P3HT layer prevented undesirable light absorption and the power conversion efficiency of this condition was increased by 44% compared to that of a reference device.

  19. An Analytical Technique to Elucidate Field Impurities From Manufacturing Uncertainties of an Double Pancake Type HTS Insert for High Field LTS/HTS NMR Magnets.

    PubMed

    Hahn, Seung-Yong; Ahn, Min Cheol; Bobrov, Emanuel Saul; Bascuñán, Juan; Iwasa, Yukikazu

    2009-06-01

    This paper addresses adverse effects of dimensional uncertainties of an HTS insert assembled with double-pancake coils on spatial field homogeneity. Each DP coil was wound with Bi2223 tapes having dimensional tolerances larger than one order of magnitude of those accepted for LTS wires used in conventional NMR magnets. The paper presents: 1) dimensional variations measured in two LTS/HTS NMR magnets, 350 MHz (LH350) and 700 MHz (LH700), both built and operated at the Francis Bitter Magnet Laboratory; and 2) an analytical technique and its application to elucidate the field impurities measured with the two LTS/HTS magnets. Field impurities computed with the analytical model and those measured with the two LTS/HTS magnets agree quite well, demonstrating that this analytical technique is applicable to design a DP-assembled HTS insert with an improved field homogeneity for a high-field LTS/HTS NMR magnet.

  20. An Analytical Technique to Elucidate Field Impurities From Manufacturing Uncertainties of an Double Pancake Type HTS Insert for High Field LTS/HTS NMR Magnets

    PubMed Central

    Hahn, Seung-yong; Ahn, Min Cheol; Bobrov, Emanuel Saul; Bascuñán, Juan; Iwasa, Yukikazu

    2010-01-01

    This paper addresses adverse effects of dimensional uncertainties of an HTS insert assembled with double-pancake coils on spatial field homogeneity. Each DP coil was wound with Bi2223 tapes having dimensional tolerances larger than one order of magnitude of those accepted for LTS wires used in conventional NMR magnets. The paper presents: 1) dimensional variations measured in two LTS/HTS NMR magnets, 350 MHz (LH350) and 700 MHz (LH700), both built and operated at the Francis Bitter Magnet Laboratory; and 2) an analytical technique and its application to elucidate the field impurities measured with the two LTS/HTS magnets. Field impurities computed with the analytical model and those measured with the two LTS/HTS magnets agree quite well, demonstrating that this analytical technique is applicable to design a DP-assembled HTS insert with an improved field homogeneity for a high-field LTS/HTS NMR magnet. PMID:20407595

  1. Mechanical analysis of insertion problems and pain during colonoscopy: Why highly skill-dependent colonoscopy routines are necessary in the first place... and how they may be avoided

    PubMed Central

    Loeve, Arjo J; Fockens, Paul; Breedveld, Paul

    2013-01-01

    BACKGROUND: Colonoscopy requires highly skill-dependent manoeuvres that demand a significant amount of training, and can cause considerable discomfort to patients, which increases the use of sedatives. Understanding the underlying fundamental mechanics behind insertion difficulties and pain during colonoscopy may help to simplify colonoscopy and reduce the required extent of training and reliance on sedatives. METHODS: A literature search, anatomical studies, models of the colon and colonoscope, and bench tests were used to qualitatively analyze the fundamental mechanical causes of insertion difficulties and pain. A categorized review resulted in an overview of potential alternatives to current colonoscopes. RESULTS: To advance a colonoscope through the colon, the colon wall, ligaments and peritoneum must be stretched, thus creating tension in the colon wall, which resists further wall deformation. This resistance forces the colonoscope to bend and follow the curves of the colon. The deformations that cause insertion difficulties and pain (necessitating the use of complex conventional manoeuvres) are the stretching of ligaments, and stretching of colon wall in the transverse and longitudinal directions, and the peritoneum. CONCLUSIONS: Four fundamental mechanical solutions to prevent these deformations were extracted from the analysis. The current results may help in the development of new colonoscopy devices that reduce – or eliminate – the necessity of using highly skill-dependent manoeuvres, facilitate training and reduce the use of sedatives. PMID:23712305

  2. The Effect of Malrotation of Tibial Component of Total Knee Arthroplasty on Tibial Insert during High Flexion Using a Finite Element Analysis

    PubMed Central

    Todo, Mitsugu

    2014-01-01

    One of the most common errors of total knee arthroplasty procedure is a malrotation of tibial component. The stress on tibial insert is closely related to polyethylene failure. The objective of this study is to analyze the effect of malrotation of tibial component for the stress on tibial insert during high flexion using a finite element analysis. We used Stryker NRG PS for analysis. Three different initial conditions of tibial component including normal, 15° internal malrotation, and 15° external malrotation were analyzed. The tibial insert made from ultra-high-molecular-weight polyethylene was assumed to be elastic-plastic while femoral and tibial metal components were assumed to be rigid. Four nonlinear springs attached to tibial component represented soft tissues around the knee. Vertical load was applied to femoral component which rotated from 0° to 135° while horizontal load along the anterior posterior axis was applied to tibial component during flexion. Maximum equivalent stresses on the surface were analyzed. Internal malrotation caused the highest stress which arose up to 160% of normal position. External malrotation also caused higher stress. Implanting prosthesis in correct position is important for reducing the risk of abnormal wear and failure. PMID:24895658

  3. Luminosity Distribution for Broad Absorption Line QSOs

    NASA Astrophysics Data System (ADS)

    Cales, S. L.; Canalizo, G.; Lacy, M.

    2004-12-01

    The relationship of Broad Absorption Line (BAL) QSOs to the general QSO population remains uncertain. We present a preliminary set of BALQSOs from a large sample of BALQSOs identified from the SDSS Data Release 2 (DR2) Catalog in order to further study the relationship. The use of the SDSS DR2 allows us to access a much larger population of BAL and non-BAL QSOs relative to previous studies. To inspect this relationship we use spectroscopic data from SDSS to compare BALQSO luminosity distributions with those of the non-BALQSO population. Within the BALQSO population, high (Hi) and low (Lo) ionization classifications are studied in relation with their luminosity distribution. Preliminary results show the LoBALQSOs appearing less luminous than the general population and more numerous that previously suggested. Their distribution also shows a secondary peak not observed in the other types of QSOs. From this data we look at three questions; first, are BALQSOs more or less luminous than the non-BALQSO population, second, are there changes in the luminosity of these types of QSOs as a function of redshift, and lastly, how do these results clarify the relationship between BALQSOs and non-BALQSOs. A discussion of possible selection effects is also included.

  4. XMM-NEWTON OBSERVATIONS REVEAL VERY HIGH X-RAY LUMINOSITY FROM THE CARBON-RICH WOLF-RAYET STAR WR 48a

    SciTech Connect

    Zhekov, Svetozar A.; Gagne, Marc; Skinner, Stephen L. E-mail: mgagne@wcupa.edu

    2011-01-20

    We present XMM-Newton observations of the dusty Wolf-Rayet (W-R) star WR 48a. This is the first detection of this object in X-rays. The XMM-Newton EPIC spectra are heavily absorbed and the presence of numerous strong emission lines indicates a thermal origin of the WR 48a X-ray emission, with dominant temperature components at kT{sub cool} {approx} 1 keV and kT{sub hot} {approx} 3 keV, the hotter component dominating the observed flux. No significant X-ray variability was detected on timescales {<=}1 day. Although the distance to WR 48a is uncertain, if it is physically associated with Open clusters Danks 1 and 2 at d {approx}4 kpc, then the resultant X-ray luminosity L{sub X}{approx} 10{sup 35} erg s{sup -1} makes it the most X-ray luminous W-R star in the Galaxy detected so far, after the black hole candidate Cyg X-3. We assume the following scenarios as the most likely explanation for the X-ray properties of WR 48a: (1) colliding stellar winds in a wide WR+O binary system, or in a hierarchical triple system with non-degenerate stellar components and (2) accretion shocks from the WR 48a wind onto a close companion (possibly a neutron star). More specific information about WR 48a and its wind properties will be needed to distinguish between the above possibilities.

  5. A novel, simple, high-throughput method for isolation of genome-wide transposon insertion mutants of Escherichia coli K-12.

    PubMed

    Miki, Takeyoshi; Yamamoto, Yoshihiro; Matsuda, Hideo

    2008-01-01

    We developed a novel, simple, high-throughput method for isolation of genome-wide transposon insertion mutants of Escherichia coli K-12. The basic idea of the method is to randomly disrupt the genes on the DNA fragments cloned on the Kohara library by inserting a mini-transposon first, and then transfer the disrupted genes from the lambda vector to the E. coli chromosome by homologous recombination. Using this method, we constructed a set of 8402 Km(r) cis-diploid mutants harboring a mini-Tn10 insertion mutation and the corresponding wild-type gene on a chromosome, as well as a set of 6954 haploid mutants derived from the cis-diploid mutants. The major advantage of the strategy used is that the indispensable genes or sites for growth can be identified. Preliminary results suggest that 415 open reading frames are indispensable for growth in E. coli cells. A total of 6404 haploid mutants were deposited to Genetic Strains Research Center, National Institute of Genetics, Japan (Chapter 26) and are available for public distribution upon request (http://shigen.lab.nig.ac.jp/ecoli/strain/nbrp/resource.jsp).

  6. Aspects of High-Resolution Gas Chromatography as Applied to the Analysis of Hydrocarbon Fuels and Other Complex Organic Mixtures. Volume 2. Survey of Sample Insertion Techniques.

    DTIC Science & Technology

    1985-06-01

    AD-A158 772 ASPECTS OF HIGH-RESOL.UTION GAS CHROMATOGRAPHY S 1ll APPLIED0 TO THE ANALYSIS 0..(U)1 DAYTON UNIV ON RESEARCH INST W A RUSEY ET AL. JUN...RESOLUTION GAS CHROMATOGRAPHY AS APPLIED TO THE ANALYSIS OF HYDROCARBON FUELS AND OTHER COMPLEX ORGANIC MIXTURES Volume II - Survey of Sample Insertion...NO. NO. 45433-6563 62203F 3048 05 91 11. TITLE (Include Security Classification) (cont’ d on reverse) ASPECTS OF HIGH-RESOLUTION GAS CHROMATOGRAPHY T

  7. Does the obscured AGN fraction really depend on luminosity?

    NASA Astrophysics Data System (ADS)

    Sazonov, S.; Churazov, E.; Krivonos, R.

    2015-12-01

    We use a sample of 151 local non-blazar active galactic nuclei (AGN) selected from the INTEGRAL all-sky hard X-ray survey to investigate if the observed declining trend of the fraction of obscured (i.e. showing X-ray absorption) AGN with increasing luminosity is mostly an intrinsic or selection effect. Using a torus-obscuration model, we demonstrate that in addition to negative bias, due to absorption in the torus, in finding obscured AGN in hard X-ray flux-limited surveys, there is also positive bias in finding unobscured AGN, due to Compton reflection in the torus. These biases can be even stronger taking into account plausible intrinsic collimation of hard X-ray emission along the axis of the obscuring torus. Given the AGN luminosity function, which steepens at high luminosities, these observational biases lead to a decreasing observed fraction of obscured AGN with increasing luminosity even if this fraction has no intrinsic luminosity dependence. We find that if the central hard X-ray source in AGN is isotropic, the intrinsic (i.e. corrected for biases) obscured AGN fraction still shows a declining trend with luminosity, although the intrinsic obscured fraction is significantly larger than the observed one: the actual fraction is larger than ˜85 per cent at L ≲ 1042.5 erg s-1 (17-60 keV), and decreases to ≲60 per cent at L ≳ 1044 erg s-1. In terms of the half-opening angle θ of an obscuring torus, this implies that θ ≲ 30° in lower luminosity AGN, and θ ≳ 45° in higher luminosity ones. If, however, the emission from the central supermassive black hole is collimated as dL/dΩ ∝ cos α, the intrinsic dependence of the obscured AGN fraction is consistent with a luminosity-independent torus half-opening angle θ ˜ 30°.

  8. Chair Inserts for Preschoolers.

    ERIC Educational Resources Information Center

    Horn, Eva; And Others

    1987-01-01

    The article provides detailed procedures (with diagrams) for constructing cardboard chair inserts to meet the needs of preschool children with minimal to severe physical limitations. The inserts offer reduced expense and increased flexibility allowing a customized fit. (DB)

  9. Pin-Hole Luminosity Monitor with Feedback

    NASA Astrophysics Data System (ADS)

    Norem, James H.; Spencer, James E.

    Previously, the generalized luminosity { L} was defined and calculated for all incident channels based on an NLC e+e- design. Alternatives were then considered to improve the differing beam-beam effects in the e-e-, eγ and γγ channels. Regardless of the channel, there was a large flux of outgoing, high energy photons that were produced from the beam-beam interaction e.g. beamstrahlung that needs to be disposed of and whose flux depended on { L}. One approach to this problem is to consider it a resource and attempt to take advantage of it by disposing of these straight-ahead photons in more useful ways than simply dumping them. While there are many options for monitoring the luminosity, any method that allows feedback and optimization in real time and in a non-intercepting and non-interfering way during normal data taking is extremely important - especially if it provides other capabilities such as high resolution tuning of spot sizes and can be used for all incident channels without essential modifications to their setup. Our "pin-hole" camera appears to be such a device if it can be made to work with high energy photons in ways that are compatible with the many other constraints and demands on space around the interaction region. The basis for using this method is that it has, in principle, the inherent resolution and bandwidth to monitor the very small spot sizes and their stabilities that are required for very high, integrated luminosity. While there are many possible, simultaneous uses of these outgoing photon beams, we limit our discussion to a single, blind, proof-of-principle experiment that was done on the FFTB line at SLAC to certify the concept of a camera obscura for high energy photons.

  10. The Cosmic-Ray Luminosity of the Galaxy

    NASA Astrophysics Data System (ADS)

    Dogiel, V. A.; Schönfelder, V.; Strong, A. W.

    2002-06-01

    The total cosmic-ray luminosity of the Galaxy is one of the main parameters that strongly constrain possible models of the origin of cosmic rays. Recently, Dar & De Rújula suggested a luminosity that is 2 orders of magnitude larger than the standard estimate. If this estimate were correct, it would completely change our conception of the origin of cosmic rays. From a number of different arguments, however, we show that the estimate of Dar & Rújula is too high.

  11. Solar Response to Luminosity Variations

    NASA Technical Reports Server (NTRS)

    Arendt, S.

    1990-01-01

    The connection between solar luminosity and magnetic fields is now well-established. Magnetic fields under the guise of sunspots and faculae enhance or suppress heat transfer through the solar surface, leading to changes in the total solar luminosity. This raises the question of the effect that such surface heat transfer perturbations have on the internal structure of the sun. The problem has been considered previously by Foukal and Spruit. Here, researchers generalize the calculation of Spruit, removing the assumption of a constant heat diffusivity coefficient by treating the full mixing length heat transfer expression. Further, they treat the surface conditions in a simpler manner, and show that the previous conclusions of Foukal and Spruit are unaffected by these modifications. The model shows that following the application of a step function emissivity change: a fraction 1 - D(sub 0) of the luminosity change relaxes away after approx. 50 days. This corresponds to the thermal diffusion time across the convection zone, adjusting to a value in correspondence with the surface change. In other words, the whole convection zone feels the perturbation on this timescale. The remaining fraction relaxes away on a timescale of 10 to the 5th power years, corresponding to the convective layer radiating away enough energy so that it can adjust to its new adiabat. These are the same results arrived at by Spruit and Foukal. For variations of sigma on timescales of 10 to 200 years, then, the only important relaxation is the 50 day one. If the amplitude of this relaxation is small, the luminosity follows the sigma variation.

  12. The luminosity function of quasars

    NASA Technical Reports Server (NTRS)

    Pei, Yichuan C.

    1995-01-01

    We propose a new evolutionary model for the optical luminosity function of quasars. Our analytical model is derived from fits to the empirical luminosity function estimated by Hartwick and Schade and Warren, Hewett, and Osmer on the basis of more than 1200 quasars over the range of redshifts 0 approximately less than z approximately less than 4.5. We find that the evolution of quasars over this entire redshift range can be well fitted by a Gaussian distribution, while the shape of the luminosity function can be well fitted by either a double power law or an exponential L(exp 1/4) law. The predicted number counts of quasars, as a function of either apparent magnitude or redshift, are fully consistent with the observed ones. Our model indicates that the evolution of quasars reaches its maximum at z approximately = 2.8 and declines at higher redshifts. An extrapolation of the evolution to z approximately greater than 4.5 implies that quasars may have started their cosmic fireworks at z(sub f) approximately = 5.2-5.5. Forthcoming surveys of quasars at these redshifts will be critical to constrain the epoch of quasar formation. All the results we derived are based on observed quasars and are therefore subject to the bias of obscuration by dust in damped Ly alpha systems. Future surveys of these absorption systems at z approximately greater than 3 will also be important if the formation epoch of quasars is to be known unambiguously.

  13. The luminosity function of quasars

    NASA Technical Reports Server (NTRS)

    Pei, Yichuan C.

    1995-01-01

    We propose a new evolutionary model for the optical luminosity function of quasars. Our analytical model is derived from fits to the empirical luminosity function estimated by Hartwick and Schade and Warren, Hewett, and Osmer on the basis of more than 1200 quasars over the range of redshifts 0 approximately less than z approximately less than 4.5. We find that the evolution of quasars over this entire redshift range can be well fitted by a Gaussian distribution, while the shape of the luminosity function can be well fitted by either a double power law or an exponential L(exp 1/4) law. The predicted number counts of quasars, as a function of either apparent magnitude or redshift, are fully consistent with the observed ones. Our model indicates that the evolution of quasars reaches its maximum at z approximately = 2.8 and declines at higher redshifts. An extrapolation of the evolution to z approximately greater than 4.5 implies that quasars may have started their cosmic fireworks at z(sub f) approximately = 5.2-5.5. Forthcoming surveys of quasars at these redshifts will be critical to constrain the epoch of quasar formation. All the results we derived are based on observed quasars and are therefore subject to the bias of obscuration by dust in damped Ly alpha systems. Future surveys of these absorption systems at z approximately greater than 3 will also be important if the formation epoch of quasars is to be known unambiguously.

  14. Higher luminosities via alternative incident channels

    SciTech Connect

    Spencer, J.E.

    1985-04-01

    We show that PEP provides some unique opportunities for one and two photon physics with real photons as well as for QCD studies with internal targets. Photon beams would avoid the major limitation on the luminosity of present machines and could provide PEP an ideal b-physics factory producing the full range of J/sub c//sup PC/ and J/sub b//sup PC/ states that may not be observable otherwise as well as allow a whole new class of ''missing-mass'' experiments. These latter particles are the pseudo-Goldstone bosons and their supersymmetric counterparts. These and related possibilities like a single-pass, ''free electron laser'' facility or even synchrotron radiation beam lines all favor a mini-maxi configuration for the low-beta insertions in PEP. This allows more diverse experiments without excluding any ongoing experimental programs. Such possibilities have interesting implications for a number of proposed facilities including the SSC. Some systematic machine physics studies over a range of energies are suggested. 24 refs., 6 figs.

  15. Finely tuning MOFs towards high performance in C2H2 storage: synthesis and properties of a new MOF-505 analogue with an inserted amide functional group.

    PubMed

    Zhang, Mingxing; Li, Bin; Li, Yunzhi; Wang, Qian; Zhang, Wenwei; Chen, Banglin; Li, Shuhua; Pan, Yi; You, Xiaozeng; Bai, Junfeng

    2016-06-07

    Aiming to improve the acetylene (C2H2) storage capability of MOFs, we successfully designed NJU-Bai 17, a new analogue of MOF-505 with an inserted amide functional group which exhibits almost record high C2H2 uptakes of 222.4 cm(3) g(-1) at 296 K and 296 cm(3) g(-1) at 273 K under 1 bar. This result has been further supported by the determination of the heat of C2H2 adsorption and Grand Canonical Monte Carlo (GCMC) and first-principle calculations.

  16. High association of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with recurrent aphthous stomatitis.

    PubMed

    Karakus, Nevin; Yigit, Serbulent; Kalkan, Goknur; Sezer, Saime

    2013-08-01

    Recurrent aphthous stomatitis (RAS) is a common ulcerative disease of the oral mucosa. Oral ulcers are also the most common feature of Behçet's disease (BD). Association of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with BD has been reported in Turkish population. The aim of the present study was to investigate the possible association between ACE gene I/D polymorphism and RAS, and evaluate if there was an association with clinical features in a relatively large cohort of Turkish patients. The study included 198 patients affected by RAS and 214 healthy controls. ACE gene I/D polymorphism genotypes were determined using polymerase chain reaction with I and D allele-specific primers. The genotype and allele frequencies of I/D polymorphism showed statistically significant differences between RAS patients and controls (p < 0.0001 and p < 0.0001, respectively). After stratifying RAS patients according to clinical and demographical characteristics, no significant association was observed. In conclusion, the results of this study suggest that I/D polymorphism of the ACE gene was positively associated with predisposition to develop RAS in Turkish population. Further studies with larger populations are recommended.

  17. The GRB luminosity function: prediction of the internal shock model and comparison to observations

    NASA Astrophysics Data System (ADS)

    Zitouni, H.; Daigne, F.; Mochkovitch, R.

    2008-05-01

    We compute the expected GRB luminosity function in the internal shock model. We find that if the population of GRB central engines produces all kind of relativistic outflows, from very smooth to highly variable, the luminosity function has to branchs: at low luminosity, the distribution is dominated by low efficiency GRBs and is close to a power law of slope -0.5, whereas at high luminosity, the luminosity function follows the distribution of injected kinetic power. Using Monte Carlo simulations and several observational constrains (BATSE logN-logP diagram, peak energy distribution of bright BATSE bursts, fraction of XRFs in the HETE2 sample), we show that it is currently impossible to distinguish between a single power law or a broken power law luminosity function. However, when the second case is considered, the low-luminosity slope is found to be -0.6+/-0.2, which is compatible with the prediction of the internal shock model.

  18. High Inter-Individual Diversity of Point Mutations, Insertions, and Deletions in Human Influenza Virus Nucleoprotein-Specific Memory B Cells.

    PubMed

    Reiche, Sven; Dwai, Yamen; Bussmann, Bianca M; Horn, Susanne; Sieg, Michael; Jassoy, Christian

    2015-01-01

    The diversity of virus-specific antibodies and of B cells among different individuals is unknown. Using single-cell cloning of antibody genes, we generated recombinant human monoclonal antibodies from influenza nucleoprotein-specific memory B cells in four adult humans with and without preceding influenza vaccination. We examined the diversity of the antibody repertoires and found that NP-specific B cells used numerous immunoglobulin genes. The heavy chains (HCs) originated from 26 and the kappa light chains (LCs) from 19 different germ line genes. Matching HC and LC chains gave rise to 43 genetically distinct antibodies that bound influenza NP. The median lengths of the CDR3 of the HC, kappa and lambda LC were 14, 9 and 11 amino acids, respectively. We identified changes at 13.6% of the amino acid positions in the V gene of the antibody heavy chain, at 8.4% in the kappa and at 10.6 % in the lambda V gene. We identified somatic insertions or deletions in 8.1% of the variable genes. We also found several small groups of clonal relatives that were highly diversified. Our findings demonstrate broadly diverse memory B cell repertoires for the influenza nucleoprotein. We found extensive variation within individuals with a high number of point mutations, insertions, and deletions, and extensive clonal diversification. Thus, structurally conserved proteins can elicit broadly diverse and highly mutated B-cell responses.

  19. High Inter-Individual Diversity of Point Mutations, Insertions, and Deletions in Human Influenza Virus Nucleoprotein-Specific Memory B Cells

    PubMed Central

    Bussmann, Bianca M.; Horn, Susanne; Sieg, Michael; Jassoy, Christian

    2015-01-01

    The diversity of virus-specific antibodies and of B cells among different individuals is unknown. Using single-cell cloning of antibody genes, we generated recombinant human monoclonal antibodies from influenza nucleoprotein-specific memory B cells in four adult humans with and without preceding influenza vaccination. We examined the diversity of the antibody repertoires and found that NP-specific B cells used numerous immunoglobulin genes. The heavy chains (HCs) originated from 26 and the kappa light chains (LCs) from 19 different germ line genes. Matching HC and LC chains gave rise to 43 genetically distinct antibodies that bound influenza NP. The median lengths of the CDR3 of the HC, kappa and lambda LC were 14, 9 and 11 amino acids, respectively. We identified changes at 13.6% of the amino acid positions in the V gene of the antibody heavy chain, at 8.4 % in the kappa and at 10.6 % in the lambda V gene. We identified somatic insertions or deletions in 8.1% of the variable genes. We also found several small groups of clonal relatives that were highly diversified. Our findings demonstrate broadly diverse memory B cell repertoires for the influenza nucleoprotein. We found extensive variation within individuals with a high number of point mutations, insertions, and deletions, and extensive clonal diversification. Thus, structurally conserved proteins can elicit broadly diverse and highly mutated B-cell responses. PMID:26086076

  20. Brochothrix thermosphacta Bacteriophages Feature Heterogeneous and Highly Mosaic Genomes and Utilize Unique Prophage Insertion Sites ▿ †

    PubMed Central

    Kilcher, Samuel; Loessner, Martin J.; Klumpp, Jochen

    2010-01-01

    Brochothrix belongs to the low-GC branch of Gram-positive bacteria (Firmicutes), closely related to Listeria, Staphylococcus, Clostridium, and Bacillus. Brochothrix thermosphacta is a nonproteolytic food spoilage organism, adapted to growth in vacuum-packaged meats. We report the first genome sequences and characterization of Brochothrix bacteriophages. Phage A9 is a myovirus with an 89-nm capsid diameter and a 171-nm contractile tail; it belongs to the Spounavirinae subfamily and shares significant homologies with Listeria phage A511, Staphylococcus phage Twort, and others. The A9 unit genome is 127 kb long with 11-kb terminal redundancy; it encodes 198 proteins and 6 tRNAs. Phages BL3 and NF5 are temperate siphoviruses with a head diameter of 56 to 59 nm. The BL3 tail is 270 nm long, whereas NF5 features a short tail of only 94 nm. The NF5 genome (36.95 kb) encodes 57 gene products, BL3 (41.52 kb) encodes 65 products, and both are arranged in life cycle-specific modules. Surprisingly, BL3 and NF5 show little relatedness to Listeria phages but rather demonstrate relatedness to lactococcal phages. Peptide mass fingerprinting of viral proteins indicate programmed −1 translational frameshifts in the NF5 capsid and the BL3 major tail protein. Both NF5 and BL3 feature circularly permuted, terminally redundant genomes, packaged by a headful mechanism, and integrases of the serine (BL3) and tyrosine (NF5) types. They utilize unique target sequences not previously described: BL3 inserts into the 3′ end of a RNA methyltransferase, whereas NF5 integrates into the 5′-terminal part of a putative histidinol-phosphatase. Interestingly, both genes are reconstituted by phage sequence. PMID:20709901

  1. Luminosity function and jet structure of Gamma-Ray Burst

    NASA Astrophysics Data System (ADS)

    Pescalli, A.; Ghirlanda, G.; Salafia, O. S.; Ghisellini, G.; Nappo, F.; Salvaterra, R.

    2015-02-01

    The structure of gamma-ray burst (GRB) jets impacts on their prompt and afterglow emission properties. The jet of GRBs could be uniform, with constant energy per unit solid angle within the jet aperture, or it could be structured, namely with energy and velocity that depend on the angular distance from the axis of the jet. We try to get some insight about the still unknown structure of GRBs by studying their luminosity function. We show that low (1046-48 erg s-1) and high (i.e. with L ≥ 1050 erg s-1) luminosity GRBs can be described by a unique luminosity function, which is also consistent with current lower limits in the intermediate luminosity range (1048-50 erg s-1). We derive analytical expressions for the luminosity function of GRBs in uniform and structured jet models and compare them with the data. Uniform jets can reproduce the entire luminosity function with reasonable values of the free parameters. A structured jet can also fit adequately the current data, provided that the energy within the jet is relatively strongly structured, i.e. E ∝ θ-k with k ≥ 4. The classical E ∝ θ-2 structured jet model is excluded by the current data.

  2. Evidence for Amino Acid Snorkeling from a High-Resolution, In Vivo Analysis of Fis1 Tail-Anchor Insertion at the Mitochondrial Outer Membrane.

    PubMed

    Keskin, Abdurrahman; Akdoğan, Emel; Dunn, Cory D

    2017-02-01

    Proteins localized to mitochondria by a carboxyl-terminal tail anchor (TA) play roles in apoptosis, mitochondrial dynamics, and mitochondrial protein import. To reveal characteristics of TAs that may be important for mitochondrial targeting, we focused our attention upon the TA of the Saccharomyces cerevisiae Fis1 protein. Specifically, we generated a library of Fis1p TA variants fused to the Gal4 transcription factor, then, using next-generation sequencing, revealed which Fis1p TA mutations inhibited membrane insertion and allowed Gal4p activity in the nucleus. Prompted by our global analysis, we subsequently analyzed the ability of individual Fis1p TA mutants to localize to mitochondria. Our findings suggest that the membrane-associated domain of the Fis1p TA may be bipartite in nature, and we encountered evidence that the positively charged patch at the carboxyl terminus of Fis1p is required for both membrane insertion and organelle specificity. Furthermore, lengthening or shortening of the Fis1p TA by up to three amino acids did not inhibit mitochondrial targeting, arguing against a model in which TA length directs insertion of TAs to distinct organelles. Most importantly, positively charged residues were more acceptable at several positions within the membrane-associated domain of the Fis1p TA than negatively charged residues. These findings, emerging from the first high-resolution analysis of an organelle targeting sequence by deep mutational scanning, provide strong, in vivo evidence that lysine and arginine can "snorkel," or become stably incorporated within a lipid bilayer by placing terminal charges of their side chains at the membrane interface. Copyright © 2017 by the Genetics Society of America.

  3. A highly polymorphic insertion in the Y-chromosome amelogenin gene can be used for evolutionary biology, population genetics and sexing in Cetacea and Artiodactyla.

    PubMed

    Macé, Matthias; Crouau-Roy, Brigitte

    2008-10-16

    The early radiation of the Cetartiodactyla is complex, and unambiguous molecular characters are needed to clarify the positions of hippotamuses, camels and pigs relative to the remaining taxa (Cetacea and Ruminantia). There is also a need for informative genealogic markers for Y-chromosome population genetics as well as a sexing method applicable to all species from this group. We therefore studied the sequence variation of a partial sequence of the evolutionary conserved amelogenin gene to assess its potential use in each of these fields. We report a large interstitial insertion in the Y amelogenin locus in most of the Cetartiodactyla lineages (cetaceans and ruminants). This sex-linked size polymorphism is the result of a 460-465 bp inserted element in intron 4 of the amelogenin gene of Ruminants and Cetaceans. Therefore, this polymorphism can easily be used in a sexing assay for these species. When taking into account this shared character in addition to nucleotide sequence, gene genealogy follows sex-chromosome divergence in Cetartiodactyla whereas it is more congruent with zoological history when ignoring these characters. This could be related to a loss of homology between chromosomal copies given the old age of the insertion. The 1 kbp Amel-Y amplified fragment is also characterized by high nucleotide diversity (64 polymorphic sites spanning over 1 kbp in seven haplotypes) which is greater than for other Y-chromosome sequence markers studied so far but less than the mitochondrial control region. The gender-dependent polymorphism we have identified is relevant not only for phylogenic inference within the Cetartiodactyla but also for Y-chromosome based population genetics and gender determination in cetaceans and ruminants. One single protocol can therefore be used for studies in population and evolutionary genetics, reproductive biotechnologies, and forensic science.

  4. A highly polymorphic insertion in the Y-chromosome amelogenin gene can be used for evolutionary biology, population genetics and sexing in Cetacea and Artiodactyla

    PubMed Central

    Macé, Matthias; Crouau-Roy, Brigitte

    2008-01-01

    Background The early radiation of the Cetartiodactyla is complex, and unambiguous molecular characters are needed to clarify the positions of hippotamuses, camels and pigs relative to the remaining taxa (Cetacea and Ruminantia). There is also a need for informative genealogic markers for Y-chromosome population genetics as well as a sexing method applicable to all species from this group. We therefore studied the sequence variation of a partial sequence of the evolutionary conserved amelogenin gene to assess its potential use in each of these fields. Results and discussion We report a large interstitial insertion in the Y amelogenin locus in most of the Cetartiodactyla lineages (cetaceans and ruminants). This sex-linked size polymorphism is the result of a 460–465 bp inserted element in intron 4 of the amelogenin gene of Ruminants and Cetaceans. Therefore, this polymorphism can easily be used in a sexing assay for these species. When taking into account this shared character in addition to nucleotide sequence, gene genealogy follows sex-chromosome divergence in Cetartiodactyla whereas it is more congruent with zoological history when ignoring these characters. This could be related to a loss of homology between chromosomal copies given the old age of the insertion. The 1 kbp Amel-Y amplified fragment is also characterized by high nucleotide diversity (64 polymorphic sites spanning over 1 kbp in seven haplotypes) which is greater than for other Y-chromosome sequence markers studied so far but less than the mitochondrial control region. Conclusion The gender-dependent polymorphism we have identified is relevant not only for phylogenic inference within the Cetartiodactyla but also for Y-chromosome based population genetics and gender determination in cetaceans and ruminants. One single protocol can therefore be used for studies in population and evolutionary genetics, reproductive biotechnologies, and forensic science. PMID:18925953

  5. Evidence for Amino Acid Snorkeling from a High-Resolution, In Vivo Analysis of Fis1 Tail-Anchor Insertion at the Mitochondrial Outer Membrane

    PubMed Central

    Keskin, Abdurrahman; Akdoğan, Emel; Dunn, Cory D.

    2017-01-01

    Proteins localized to mitochondria by a carboxyl-terminal tail anchor (TA) play roles in apoptosis, mitochondrial dynamics, and mitochondrial protein import. To reveal characteristics of TAs that may be important for mitochondrial targeting, we focused our attention upon the TA of the Saccharomyces cerevisiae Fis1 protein. Specifically, we generated a library of Fis1p TA variants fused to the Gal4 transcription factor, then, using next-generation sequencing, revealed which Fis1p TA mutations inhibited membrane insertion and allowed Gal4p activity in the nucleus. Prompted by our global analysis, we subsequently analyzed the ability of individual Fis1p TA mutants to localize to mitochondria. Our findings suggest that the membrane-associated domain of the Fis1p TA may be bipartite in nature, and we encountered evidence that the positively charged patch at the carboxyl terminus of Fis1p is required for both membrane insertion and organelle specificity. Furthermore, lengthening or shortening of the Fis1p TA by up to three amino acids did not inhibit mitochondrial targeting, arguing against a model in which TA length directs insertion of TAs to distinct organelles. Most importantly, positively charged residues were more acceptable at several positions within the membrane-associated domain of the Fis1p TA than negatively charged residues. These findings, emerging from the first high-resolution analysis of an organelle targeting sequence by deep mutational scanning, provide strong, in vivo evidence that lysine and arginine can “snorkel,” or become stably incorporated within a lipid bilayer by placing terminal charges of their side chains at the membrane interface. PMID:28007883

  6. Luminosity Dependence and Search Doppler

    NASA Technical Reports Server (NTRS)

    VanParadijs, Johannes A.

    1998-01-01

    The research supported by this grant covered two projects: (1) a study of the luminosity dependence of the properties of atoll sources; and (2) a search for Doppler shifts in the pulse arrival times of the anomalous pulsar 4U 0142+61. Following the discovery of kilohertz quasi-periodic oscillations (QPOS) in Sco X-1 studies of the X-ray properties of atoll sources have been dominated by searches for these QPOS, and the study of their dependence on other source properties, such as X-ray luminosity and spectral state. In the project supported by grant NAG5-3269 we have detected kHz QPOs for several atoll sources. The physical interpretation of these QPO is as yet unclear, but simple models (such as the Keplerian beat frequency model) can probably be excluded. The results of this research have been reported. We have studied the X-ray pulsations of the anomalous X-ray pulsar 4U 0142+61 using the Rossi XTE. A detailed search for Doppler shifts did not lead to a positive detection. The upper limits exclude almost all types of possible companion stars, except white dwarfs. However, the latter can be excluded since anomalous X-ray pulsars are very young objects. We therefore conclude that anomalous X-ray pulsars are single neutron stars.

  7. The cosmological evolution and luminosity function of X-ray selected active galactic nuclei

    NASA Technical Reports Server (NTRS)

    Maccacaro, T.; Gioia, I. M.; Avni, Y.; Giommi, P.; Griffiths, R. E.; Liebert, J.; Stocke, J.; Danziger, J.

    1983-01-01

    The cosmological evolution and the X-ray luminosity function of X-ray selected active galactic nuclei (AGNs) are derived and discussed. The sample used consists of 31 AGNs extracted from a fully identified sample of X-ray sources from the Einstein Observatory Medium Sensitivity Survey and is therefore exclusively defined by its X-ray properties. The distribution in space is found to be strongly nonuniform. The amount of cosmological evolution required by the X-ray data is derived in the framework of pure luminosity evolution and is found to be smaller than the amount determined from optically selected samples. The X-ray luminosity function is derived. It can be satisfactorily represented by a single power law only over a limited range of absolute luminosities. Evidence that the luminosity function flattens at low luminosity or steepens at high luminosity, or both, is presented and discussed.

  8. The genetic diversity and evolution of field pea (Pisum) studied by high throughput retrotransposon based insertion polymorphism (RBIP) marker analysis

    PubMed Central

    2010-01-01

    Background The genetic diversity of crop species is the result of natural selection on the wild progenitor and human intervention by ancient and modern farmers and breeders. The genomes of modern cultivars, old cultivated landraces, ecotypes and wild relatives reflect the effects of these forces and provide insights into germplasm structural diversity, the geographical dimension to species diversity and the process of domestication of wild organisms. This issue is also of great practical importance for crop improvement because wild germplasm represents a rich potential source of useful under-exploited alleles or allele combinations. The aim of the present study was to analyse a major Pisum germplasm collection to gain a broad understanding of the diversity and evolution of Pisum and provide a new rational framework for designing germplasm core collections of the genus. Results 3020 Pisum germplasm samples from the John Innes Pisum germplasm collection were genotyped for 45 retrotransposon based insertion polymorphism (RBIP) markers by the Tagged Array Marker (TAM) method. The data set was stored in a purpose-built Germinate relational database and analysed by both principal coordinate analysis and a nested application of the Structure program which yielded substantially similar but complementary views of the diversity of the genus Pisum. Structure revealed three Groups (1-3) corresponding approximately to landrace, cultivar and wild Pisum respectively, which were resolved by nested Structure analysis into 14 Sub-Groups, many of which correlate with taxonomic sub-divisions of Pisum, domestication related phenotypic traits and/or restricted geographical locations. Genetic distances calculated between these Sub-Groups are broadly supported by principal coordinate analysis and these, together with the trait and geographical data, were used to infer a detailed model for the domestication of Pisum. Conclusions These data provide a clear picture of the major distinct gene

  9. Targeted chromosomal insertion of large DNA into the human genome by a fiber-modified high-capacity adenovirus-based vector system.

    PubMed

    Gonçalves, Manuel A F V; Holkers, Maarten; van Nierop, Gijsbert P; Wieringa, Roeland; Pau, Maria G; de Vries, Antoine A F

    2008-08-29

    A prominent goal in gene therapy research concerns the development of gene transfer vehicles that can integrate exogenous DNA at specific chromosomal loci to prevent insertional oncogenesis and provide for long-term transgene expression. Adenovirus (Ad) vectors arguably represent the most efficient delivery systems of episomal DNA into eukaryotic cell nuclei. The most advanced recombinant Ads lack all adenoviral genes. This renders these so-called high-capacity (hc) Ad vectors less cytotoxic/immunogenic than those only deleted in early regions and creates space for the insertion of large/multiple transgenes. The versatility of hcAd vectors is been increased by capsid modifications to alter their tropism and by the incorporation into their genomes of sequences promoting chromosomal insertion of exogenous DNA. Adeno-associated virus (AAV) can insert its genome into a specific human locus designated AAVS1. Trans- and cis-acting elements needed for this reaction are the AAV Rep78/68 proteins and Rep78/68-binding sequences, respectively. Here, we describe the generation, characterization and testing of fiber-modified dual hcAd/AAV hybrid vectors (dHVs) containing both these elements. Due to the inhibitory effects of Rep78/68 on Ad-dependent DNA replication, we deployed a recombinase-inducible gene switch to repress Rep68 synthesis during vector rescue and propagation. Flow cytometric analyses revealed that rep68-positive dHVs can be produced similarly well as rep68-negative control vectors. Western blot experiments and immunofluorescence microscopy analyses demonstrated transfer of recombinase-dependent rep68 genes into target cells. Studies in HeLa cells and in the dystrophin-deficient myoblasts from a Duchenne muscular dystrophy (DMD) patient showed that induction of Rep68 synthesis in cells transduced with fiber-modified and rep68-positive dHVs leads to increased stable transduction levels and AAVS1-targeted integration of vector DNA. These results warrant further

  10. Unveiling TiNb2 O7 as an insertion anode for lithium ion capacitors with high energy and power density.

    PubMed

    Aravindan, Vanchiappan; Sundaramurthy, Jayaraman; Jain, Akshay; Kumar, Palaniswamy Suresh; Ling, Wong Chui; Ramakrishna, Seeram; Srinivasan, Madapusi P; Madhavi, Srinivasan

    2014-07-01

    This is the first report of the utilization of TiNb2 O7 as an insertion-type anode in a lithium-ion hybrid electrochemical capacitor (Li-HEC) along with an activated carbon (AC) counter electrode derived from a coconut shell. A simple and scalable electrospinning technique is adopted to prepare one-dimensional TiNb2 O7 nanofibers that can be characterized by XRD with Rietveld refinement, SEM, and TEM. The lithium insertion properties of such electrospun TiNb2 O7 are evaluated in the half-cell configuration (Li/TiNb2 O7 ) and it is found that the reversible intercalation of lithium (≈3.45 mol) is feasible with good capacity retention characteristics. The Li-HEC is constructed with an optimized mass loading based on the electrochemical performance of both the TiNb2 O7 anode and AC counter electrode in nonaqueous media. The Li-HEC delivers very high energy and power densities of approximately 43 Wh kg(-1) and 3 kW kg(-1) , respectively. Furthermore, the AC/TiNb2 O7 Li-HEC delivers a good cyclability of 3000 cycles with about 84% of the initial value.

  11. Mass Accretion Rate of Very Low Luminosity Objects

    NASA Astrophysics Data System (ADS)

    Sung, Ren-Shiang; Lai, Shih-Ping; Hsieh, Tien-Hao

    2013-08-01

    We propose to measure the mass accretion rate of six Very Low Luminosity Objects (VeLLOs) using Near-infrared Integral Spectrometer (NIFS). The extremely low luminosity of VeLLOs, L_int ≤ 0.1 L_⊙, was previously thought not existing in the nature because the typical accretion rate gives much larger accretion luminosity even for the lowest mass star (``Luminosity Problem''). The commonly accepted solution is that the accretion rate is not constant but episodic. Thus, VeLLOs could be interpreted as protostars being in the quiescent phase of accretion activities. However, there is no observational data directly measuring the mass accretion rate of VeLLOs. The main goal of this proposal is to examine such theory and directly measure the mass accretion rate of VeLLOs for the first time. We propose to measure the blue continuum excess (veiling) of the stellar spectrum, which is the most reliable method for measuring the accretion rate. The measurements have to be made in infrared due to the very high extinction for highly embedded protostars. Our proposal provide a first opportunity to explain the long time ``Luminosity Problem'' through the observational aspects, and Gemini is the only instrument that can provide accurate and high sensitivity infrared spectroscopy measurements within reasonably short time scale.

  12. The First Detection of (O IV) from an Ultraluminous X-Ray Source with Spitzer. 2. Evidence for High Luminosity in Holmberg II ULX

    DTIC Science & Technology

    2010-01-01

    from the accretion disk of the binary system and inconsistent with narrow beaming. We show that the emission nebula is matter- bounded both in the line...making them very dif- ficult to characterize. The ionization nebulae surrounding some ULXs have become critical for understanding the properties of...Abolmasov et al. 2007). It is located inside an ionized nebula (the “Foot nebula ”), and shows high- ionization optical emission lines coincident with

  13. On the Radio and Optical Luminosity Evolution of Quasars

    SciTech Connect

    Singal, J.; Petrosian, V.; Lawrence, A.; Stawarz, L.; /JAXA, Sagamihara /Jagiellonian U., Astron. Observ.

    2011-05-20

    We calculate simultaneously the radio and optical luminosity evolutions of quasars, and the distribution in radio loudness R defined as the ratio of radio and optical luminosities, using a flux limited data set containing 636 quasars with radio and optical fluxes from White et al. We first note that when dealing with multivariate data it is imperative to first determine the true correlations among the variables, not those introduced by the observational selection effects, before obtaining the individual distributions of the variables. We use the methods developed by Efron and Petrosian which are designed to obtain unbiased correlations, distributions, and evolution with redshift from a data set truncated due to observational biases. It is found that as expected the population of quasars exhibits strong positive correlation between the radio and optical luminosities and that this correlation deviates from a simple linear relation in a way indicating that more luminous quasars are more radio loud. We also find that there is a strong luminosity evolution with redshift in both wavebands, with significantly higher radio than optical evolution. We conclude that the luminosity evolution obtained by arbitrarily separating the sources into radio loud (R > 10) and radio quiet (R < 10) populations introduces significant biases that skew the result considerably. We also construct the local radio and optical luminosity functions and the density evolution. Finally, we consider the distribution of the radio loudness parameter R obtained from careful treatment of the selection effects and luminosity evolutions with that obtained from the raw data without such considerations. We find a significant difference between the two distributions and no clear sign of bi-modality in the true distribution. Our results indicate therefore, somewhat surprisingly, that there is no critical switch in the efficiency of the production of disk outflows/jets between very radio quiet and very radio

  14. Construction of luminosity function for galaxy clusters

    NASA Astrophysics Data System (ADS)

    Godłowski, Włodzimierz; Popiela, Joanna; Bajan, Katarzyna; Biernacka, Monika; Flin, Piotr; Panko, Elena

    2015-02-01

    The luminosity function is an important quantity for analysis of large scale structure statistics, interpretation of galaxy counts (Lin & Kirshner 1996). We investigate the luminosity function of galaxy clusters. This is performed by counting the brightness of galaxies belonging to clusters in PF Catalogue. The obtained luminosity function is significantly different than that obtained both for optical and radiogalaxies (Machalski & Godowski 2000). The implications of this result for theories of galaxy formation are discussed as well.

  15. Is the dependence of spectral index on luminosity real in optically selected AGN samples?

    NASA Astrophysics Data System (ADS)

    Tang, Su Min; Zhang, Shuang Nan; Hopkins, Philip F.

    2007-05-01

    We critically examine the dependence of spectral index on luminosity in optically selected AGN samples. An analysis of optically selected high-z quasars showed an anticorrelation of αOX, the spectral index between the rest-frame 2500 Å and 2 keV, with optical luminosity. We examine this relationship by means of Monte Carlo simulations and conclude that a constant αOX independent of optical luminosity is still consistent with this high-z sample. We further find that contributions of large dispersions and narrow range of optical luminosity are most important for the apparent, yet artificial, αOX-lo correlation reported. We also examine another, but more complete, low-z optical selected AGN sub-sample from Steffen et al., and our analysis shows that a constant αOX independent of optical luminosity is also consistent with the data. By comparing X-ray and optical luminosity functions, we find that a luminosity-independent αOX is in fact more preferred than the luminosity-dependent αOX model. We also discuss the selection effects caused by flux limits, which might systematically bias the lX-lo relation and cause discrepancy in optically selected and X-ray selected AGN samples. To correctly establish a dependence of αOX of AGNs on their luminosity, a larger and more complete sample is needed and consequences of luminosity dispersions and selection effects in flux-limited samples must be taken into account properly.

  16. Control of the static and high-frequency magnetic properties of perpendicular anisotropic Co–HfN granular films through insertion of HfN interlayers

    NASA Astrophysics Data System (ADS)

    Cao, Yang; Zhang, Yiwen; Ohnuma, Shigehiro; Kobayashi, Nobukiyo; Masumoto, Hiroshi

    2017-04-01

    We propose a multilayer granular structure wherein Hf–nitride (HfN) interlayers are inserted into Co–HfN granular films with perpendicular magnetic anisotropy (PMA) to control their static and high-frequency magnetic properties. The transition between soft ferromagnetic properties and PMA was achieved by varying the thickness of Co–HfN layers (2–30 nm) and HfN interlayers (1–4 nm). The resonance frequency of the Co–HfN (24 nm)/HfN films decreased from 2 to 0.9 GHz with increasing HfN interlayer thickness, owning to the separation of the columnar granules and reduced interlayer interaction between Co–HfN granular layers via a HfN interlayer.

  17. Strontium Insertion in Methylammonium Lead Iodide: Long Charge Carrier Lifetime and High Fill-Factor Solar Cells

    SciTech Connect

    Pérez-del-Rey, Daniel; Savenije, Tom J.; Nordlund, Dennis; Schulz, Philip; Berry, Joseph J.; Sessolo, Michele

    2016-09-22

    The addition of Sr2+ in CH3NH3PbI3 perovskite films enhances the charge carrier collection efficiency of solar cells leading to very high fill factors, up to 85%. The charge carrier lifetime of Sr2+-containing perovskites is in excess of 40 us, longer than those reported for perovskite single crystals.

  18. Cost-effectiveness of guidelines for insertion of inferior vena cava filters in high-risk trauma patients.

    PubMed

    Spangler, Emily L; Dillavou, Ellen D; Smith, Kenneth J

    2010-12-01

    Inferior vena cava filters (IVCFs) can prevent pulmonary embolism (PE); however, indications for use vary. The Eastern Association for the Surgery of Trauma (EAST) 2002 guidelines suggest prophylactic IVCF use in high-risk patients, but the American College of Chest Physicians (ACCP) 2008 guidelines do not. This analysis compares cost-effectiveness of prophylactic vs therapeutic retrievable IVCF placement in high-risk trauma patients. Markov modeling was used to determine incremental cost-effectiveness of these guidelines in dollars per quality-adjusted life-years (QALYs) during hospitalization and long-term follow-up. Our population was 46-year-old trauma patients at high risk for venous thromboembolism (VTE) by EAST criteria to whom either the EAST (prophylactic IVCF) or ACCP (no prophylactic IVCF) guidelines were applied. The analysis assumed the societal perspective over a lifetime. For base case and sensitivity analyses, probabilities and utilities were obtained from published literature and costs calculated from Centers for Medicare & Medicaid Services fee schedules, the Healthcare Cost & Utilization Project database, and Red Book wholesale drug prices for 2007. For data unavailable from the literature, similarities to other populations were used to make assumptions. In base case analysis, prophylactic IVCFs were more costly ($37,700 vs $37,300) and less effective (by 0.139 QALYs) than therapeutic IVCFs. In sensitivity analysis, the EAST strategy of prophylactic filter placement would become the preferred strategy in individuals never having a filter, with either an annual probability of VTE of ≥ 9.6% (base case, 5.9%), or a very high annual probability of anticoagulation complications of ≥ 24.3% (base case, 2.5%). The EAST strategy would also be favored if the annual probability of venous insufficiency was <7.69% (base case, 13.9%) after filter removal or <1.90% with a retained filter (base case, 14.1%). In initial hospitalization only, EAST guidelines

  19. Measuring the Radius of a Neutron Star; Origin of High X-Ray Luminosities in Optically Passive Galaxies; Resolving the Source of X-Rays in IC 1613"

    NASA Technical Reports Server (NTRS)

    Helfand, David J.

    1998-01-01

    This recently expired grant has supported the work of the PI, his students, and his collaborators on a variety of ROSAT projects over the past three years. Annual reports have summarized much of the work accomplished; here we provide a brief review of the work resulting from this effort, and a summary of the personnel who have benefited from its support. A high resolution ROSAT HRI X-ray image of the Local Group dwarf IC1613 revealed that the principal source of X-ray emission in this direction arises in a background cluster of galaxies, as first suggested by Eskridge (1995). In addition, however, we found a bright X-ray source coincident with the only known supernova remnant in this galaxy, S # 8. Extensive ground-based follow-up observations in the radio and optical regimes were conducted. We confirmed the nonthermal radio spectral index of the source and measured its extent to be approx. 3 sec at 20 cm. Imaging spectrophotometric observations taken with the multi-pupil spectrograph of the Special Astrophysical Observatory in the FSU allowed us to determine the density and velocity distribution of the gas in the remnant. The simultaneous presence of luminous X-ray and optical emission suggests a relatively young remnant in which the outward-moving shock has recently encountered dense material. Many of this object's properties are similar to those of the brightest optical remnant in the Large Magellanic Cloud, N49. Another potential source of X-rays in this galaxy which featured prominently in our original proposal, an Oxygen Wolf-Rayet star with a large surrounding wind-blown bubble, was not detected.

  20. Measuring the Radius of a Neutron Star; Origin of High X-Ray Luminosities in Optically Passive Galaxies; Resolving the Source of X-Rays in IC 1613"

    NASA Technical Reports Server (NTRS)

    Helfand, David J.

    1998-01-01

    This recently expired grant has supported the work of the PI, his students, and his collaborators on a variety of ROSAT projects over the past three years. Annual reports have summarized much of the work accomplished; here we provide a brief review of the work resulting from this effort, and a summary of the personnel who have benefited from its support. A high resolution ROSAT HRI X-ray image of the Local Group dwarf IC1613 revealed that the principal source of X-ray emission in this direction arises in a background cluster of galaxies, as first suggested by Eskridge (1995). In addition, however, we found a bright X-ray source coincident with the only known supernova remnant in this galaxy, S # 8. Extensive ground-based follow-up observations in the radio and optical regimes were conducted. We confirmed the nonthermal radio spectral index of the source and measured its extent to be approx. 3 sec at 20 cm. Imaging spectrophotometric observations taken with the multi-pupil spectrograph of the Special Astrophysical Observatory in the FSU allowed us to determine the density and velocity distribution of the gas in the remnant. The simultaneous presence of luminous X-ray and optical emission suggests a relatively young remnant in which the outward-moving shock has recently encountered dense material. Many of this object's properties are similar to those of the brightest optical remnant in the Large Magellanic Cloud, N49. Another potential source of X-rays in this galaxy which featured prominently in our original proposal, an Oxygen Wolf-Rayet star with a large surrounding wind-blown bubble, was not detected.

  1. Implications of the Observed Ultraluminous X-Ray Source Luminosity Function

    NASA Technical Reports Server (NTRS)

    Swartz, Douglas A.; Tennant, Allyn; Soria, Roberto; Yukita, Mihoko

    2012-01-01

    We present the X-ray luminosity function (XLF) of ultraluminous X-ray (ULX) sources with 0.3-10.0 keV luminosities in excess of 10(sup 39) erg/s in a complete sample of nearby galaxies. The XLF shows a break or cut-off at high luminosities that deviates from its pure power law distribution at lower luminosities. The cut-off is at roughly the Eddington luminosity for a 90-140 solar mass accretor. We examine the effects on the observed XLF of sample biases, of small-number statistics (at the high luminosity end) and of measurement uncertainties. We consider the physical implications of the shape and normalization of the XLF. The XLF is also compared and contrasted to results of other recent surveys.

  2. Grommet Having Metal Insert

    DTIC Science & Technology

    1998-09-28

    axially with respect to the body. The 1 means for releasably securing a tool to the insert comprises 2 female threads formed on an inner surface of the...below 10 the flange 32. These surfaces 34, 36 are threaded ( female 11 threads) so that the end of a tool 38 having male threads can 12 engage the...further includes a rigid insert secured to the body in the 12 centrally located aperture. The insert has female threads formed 13 therein for releasably

  3. Operation of the AFS at L = 1. 4 x 10/sup 32/ cm/sup -2/ sec/sup -1/: a first look at data at high luminosity from the CERN ISR. [Axial Field Spectrometer

    SciTech Connect

    Not Available

    1983-01-01

    In December 1982 a run was made at the CERN ISR which utilized the superconducting low beta quadrupoles in intersection I8 at the ISR and achieved a luminosity of 1.4 x 10/sup 32/ cm/sup -2/ sec/sup -1/ for 26 x 26 GeV pp collisions. At this luminosity the mean time between inelastic collisions is about 200 ns. A comparison run was also made at the same energy with a luminosity of 3.0 x 10/sup 30/ cm/sup -2/ sec/sup -1/. The luminosity under normal running conditions is typically 1.5 x 10/sup 31/ cm/sup -2/ sec/sup -1/. Data were collected with the Axial Field Spectrometer with a variety of calorimeter triggers. The calorimeter is a uranium-scintillator sandwich type with wavelength shifter readout and covers the polar angle range 50/sup 0/ < theta < 130/sup 0/. The shaping amplifiers used in the trigger have an integration time of 60 ns and the ADC gate for the photomultiplier signals has a length of 120 ns. The triggers ranged from a nonselective total transverse energy trigger (E/sub TOT/) to more selective jet and single particle triggers. The jet trigger summed the transverse energy in an azimuthal range ..delta.. phi approx. = 45/sup 0/. We have compared several trigger rates at the two luminosities to see if the observed rates scale with the luminosity.

  4. High-sensitivity temperature-independent force sensor based on PS-LPFG formed by inserting a microbend

    NASA Astrophysics Data System (ADS)

    Li, Xiaolan; Zhang, Yanxin; Zhang, Weigang; Yan, Tieyi

    2017-03-01

    A unique phase-shifted long period grating (PS-LPFG) is proposed and demonstrated by means of fabricating a microbend in the center of LPFG written by CO2 laser. Experiments demonstrate that this PS-LPFG can be used to develop a promising high sensitive force sensor by measuring the wavelength separation between the two resonance loss dips. Moreover, the wavelength separation is insensitive to the external temperature. The force sensitivity of the PS-LPFG with a bending radius 2.62 mm is measured to be up to ‑186.74 nm N‑1, which is enhanced two orders compared to the LPFG without a microbend.

  5. The rate and luminosity function of long gamma ray bursts

    NASA Astrophysics Data System (ADS)

    Pescalli, A.; Ghirlanda, G.; Salvaterra, R.; Ghisellini, G.; Vergani, S. D.; Nappo, F.; Salafia, O. S.; Melandri, A.; Covino, S.; Götz, D.

    2016-03-01

    We derive, adopting a direct method, the luminosity function and the formation rate of long Gamma Ray Bursts through a complete, flux-limited, sample of Swift bursts which has a high level of completeness in redshift z (~82%). We parametrise the redshift evolution of the GRB luminosity as L = L0(1 + z)k and we derive k = 2.5, consistently with recent estimates. The de-evolved luminosity function φ(L0) of GRBs can be represented by a broken power law with slopes a = -1.32 ± 0.21 and b = -1.84 ± 0.24 below and above, respectively, a break luminosity L0,b = 1051.45±0.15 erg/s. Under the hypothesis of luminosity evolution we find that the GRB formation rate increases with redshift up to z ~ 2, where it peaks, and then decreases in agreement with the shape of the cosmic star formation rate. We test the direct method through numerical simulations and we show that if it is applied to incomplete (both in redshift and/or flux) GRB samples it can misleadingly result in an excess of the GRB formation rate at low redshifts.

  6. Strontium insertion in methlyammonium lead iodide: long charge carrier lifetime and high fill factor solar cells (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Momblona, Cristina; Gil-Escrig, Lidón; Ávila, Jorge; Pérez-Del-Rey, Daniel; Forgács, David; Sessolo, Michele; Bolink, Hendrik J.

    2016-09-01

    Organic-inorganic (hybrid) lead halide perovskites are taking the lead among the emerging photovoltaics technologies, thanks to the demonstration of power conversion efficiencies exceeding 20 %. Hybrid perovskites have a wide spectrum of desirable properties; they are direct bandgap semiconductors with very high absorption coefficients, high and balanced hole and electron mobility, and large diffusion length. A unique feature of these materials is their versatility in terms of bandgap energy, which can be tuned by simple exchange of their components. In this paper we present vacuum and hybrid deposition routes for the preparation of different organic-inorganic lead perovskite thin films, and their incorporation into efficient solar cells. The influence of the type of organic semiconductors used as hole/electron transport layer in p-i-n solar cells will be presented. We also discuss their electroluminescence properties, either for applications in light-emitting diodes or as a diagnostic tool of the optical and electronic quality of perovskite thin films. Finally, the effect of additives and dopants in the perovskite absorber as well as in the charge selective layers will be described.

  7. Total hip arthroplasty using the Wroblewski golf ball cup inserted through the posterior approach. A high rate of dislocation.

    PubMed

    Porter, P; Stone, M H

    2004-07-01

    The Wroblewski golf ball acetabular cup was introduced by surgeons using the trochanteric osteotomy approach for revision total hip replacement (THR) in order to reduce the rate of dislocation. We have routinely used the Ogee long posterior wall (Ogee LPW) and the Wroblewski angle bore cups in THR. Although the new Wroblewski golf ball cup performed well there was a significant early rate of dislocation of 20%. Our rate of dislocation over a period of ten years using the Ogee LPW and Wroblewski angle bore cups had been 0.52%. We present our findings and an investigation as to why the new cup has such a high rate of dislocation when used with the posterior approach. We show that a relatively small change in the design of the acetabular component resulted in significant adverse clinical results.

  8. Correlation analysis of radio properties and accretion-disk luminosity for low luminosity AGNs

    NASA Astrophysics Data System (ADS)

    Su, Renzhi; Liu, Xiang; Zhang, Zhen

    2017-01-01

    The correlation between the jet power and accretion disk luminosity is investigated and analyzed with our model for 7 samples of low luminosity active galactic nuclei (LLAGNs). The main results are: (1) the power-law correlation index (P_{jet} ∝ L_{disk} ^{μ}) typically ranges μ=0.4-0.7 for the LLAGN samples, and there is a hint of steep index for the LLAGN sample which hosted by a high fraction of elliptical galaxies, and there are no significant correlation between the μ and the LLAGN types (Seyfert, LINER); (2) for μ≈1, as noted in Liu et al., the accretion disk dominates the jet power and the black hole (BH) spin is not important, for the LLAGN samples studied in this paper we find that the μ is significantly less than unity, implying that BH spin may play a significant role in the jet power of LLAGNs; (3) the BH spin-jet power is negatively correlated with the BH mass in our model, which means a high spin-jet efficiency in the `low' BH-mass LLAGNs; (4) an anti-correlation between radio loudness and disk luminosity is found, which is apparently due to the flatter power-law index in the jet-disk correlation of the LLAGNs, and the radio loudness can be higher in the LLAGNs than in luminous AGNs/quasars when the BH spin-jet power is comparable to or dominate over the accretion-jet power in the LLAGNs. The high radio-core dominance of the LLAGNs is also discussed.

  9. Plastic pipe insertion

    SciTech Connect

    Diskin, J.

    1987-05-01

    In March 1987 KPL changed all that when the utility inserted 1,000 ft of 16-in. SDR 15.5 Phillips Driscopipe 8000 pipe with a wall thickness of 1.032-in., into an abandoned 24-in. cast-iron line in downtown Kansas City. This is believed to be the largest diameter insert removal job ever done for gas distribution in the U.S. For KPL it was a natural progression from the smaller sizes used earlier. The procedure is the same, and the operation was quick and comparatively simple. Lower construction costs were the bottom line because with insert renewal there is no need to cut up the streets, a major expense in any urban pipeline work. There are other significant costs savings as well because the insert renewal construction process is faster than other techniques.

  10. Ear tube insertion - slideshow

    MedlinePlus

    ... this page: //medlineplus.gov/ency/presentations/100045.htm Ear tube insertion - series—Normal anatomy To use the ... 4 Overview The eardrum (tympanic membrane) separates the ear canal from the middle ear. Review Date 8/ ...

  11. LUMINOSITY OPTIMIZATION USING AUTOMATED IR STEERING AT RHIC.

    SciTech Connect

    DREES,A.D'OTTAVIO,T.

    2004-07-05

    The goal of the RHIC 2004 Au-Au run was to maximize the achieved integrated luminosity. One way is to increase beam currents and minimize beam transverse emittances. Another important ingredient is the minimization of time spent on activities postponing the declaration of ''physics conditions'', i.e. stable beam conditions allowing the experimental detectors to take data. Since collision rates are particularly high in the beginning of the store the integrated luminosity benefits considerably from any minute saved early in the store. In the RHIC run 2004 a new IR steering application uses luminosity monitor signals as a feedback for a fully automated steering procedure. This report gives an overview of the used procedure and summarizes the achieved results.

  12. Luminosity limit for alpha-viscosity accretion disks

    NASA Technical Reports Server (NTRS)

    Liang, Edison P.; Wandel, Amri

    1991-01-01

    The existence of a luminosity limit for alpha-viscosity physically thin accretion disks around black holes is established, using a new formulation of the radiation equation bridging optically thick and thin regimes. For alpha close to unity, this limit can be lower than the Eddington limit. Physically, this limit is due to the combined effects of gas and radiation pressure which become too large to satisfy vertical hydrostatic balance at intermediate optical depths for sufficiently high luminosities. This effect was overlooked in previous treatments using only the optically thin or thick limits of the radiative equation.

  13. Characterization of new hybrid pixel module concepts for the ATLAS Insertable B-Layer upgrade

    NASA Astrophysics Data System (ADS)

    Backhaus, M.

    2012-01-01

    The ATLAS Insertable B-Layer (IBL) collaboration plans to insert a fourth pixel layer inside the present Pixel Detector to recover from eventual failures in the current pixel system, especially the b-layer. Additionally the IBL will ensure excellent tracking, vertexing and b-tagging performance during the LHC phase I and add robustness in tracking with high luminosity pile-up. The expected peak luminosity for IBL is 2 to 3·1034 cm-2s-1 and IBL is designed for an integrated luminosity of 700 fb-1. This corresponds to an expected fluence of 5·1015 1 MeV neqcm-2 and a total ionizing dose of 250 MRad. In order to cope with these requirements, two new module concepts are under investigation, both based on a new front end IC, called FE-I4. This IC was designed as readout chip for future ATLAS Pixel Detectors and its first application will be the IBL. The planar pixel sensor (PPS) based module concept benefits from its well understood design, which is kept as similar as possible to the design of the current ATLAS Pixel Detector sensor. The second approach of the new three dimensional (3D) silicon sensor technology benefits from the shorter charge carrier drift distance to the electrodes, which completely penetrate the sensor bulk. Prototype modules of both sensor concepts have been build and tested in laboratory and test beam environment before and after irradiation. Both concepts show very high performance even after irradiation to 5·1015 1 MeV neqcm-2 and meet the IBL specifications in terms of hit efficiency being larger than 97%. Lowest operational threshold studies have been effected and prove independent of the used sensor concept the excellent performance of FE-I4 based module concepts in terms of noise hit occupancy at low thresholds.

  14. A Flexible Method of Estimating Luminosity Functions

    NASA Astrophysics Data System (ADS)

    Kelly, Brandon C.; Fan, Xiaohui; Vestergaard, Marianne

    2008-08-01

    We describe a Bayesian approach to estimating luminosity functions. We derive the likelihood function and posterior probability distribution for the luminosity function, given the observed data, and we compare the Bayesian approach with maximum likelihood by simulating sources from a Schechter function. For our simulations confidence intervals derived from bootstrapping the maximum likelihood estimate can be too narrow, while confidence intervals derived from the Bayesian approach are valid. We develop our statistical approach for a flexible model where the luminosity function is modeled as a mixture of Gaussian functions. Statistical inference is performed using Markov chain Monte Carlo (MCMC) methods, and we describe a Metropolis-Hastings algorithm to perform the MCMC. The MCMC simulates random draws from the probability distribution of the luminosity function parameters, given the data, and we use a simulated data set to show how these random draws may be used to estimate the probability distribution for the luminosity function. In addition, we show how the MCMC output may be used to estimate the probability distribution of any quantities derived from the luminosity function, such as the peak in the space density of quasars. The Bayesian method we develop has the advantage that it is able to place accurate constraints on the luminosity function even beyond the survey detection limits, and that it provides a natural way of estimating the probability distribution of any quantities derived from the luminosity function, including those that rely on information beyond the survey detection limits.

  15. The Tonantzintla Search for High Luminosity Stars

    NASA Astrophysics Data System (ADS)

    Abt, H. A.

    2011-04-01

    Starting with the paper by G. González and G. González, 1952, BOTT, 1, 5, 1 in the first volume of the Bulletin, various Tonantzintla astronomers worked for years to find the OB stars that delineate the local spiral arms. Perhaps they became discouraged when the 21 cm radio maps appeared, but they should not have been because the optical data produce distances while the radio data measure only radial motions, that need to be interpreted with a model of the motions in our Galaxy. Those motions are more complicated than they thought, so their maps are very inaccurate. The recent 4.5 μm infrared map shows our Galaxy to have a central bar, two major spiral arms, and five small ones.

  16. Can Sequentially-irradiated and Annealed Highly Cross-linked Polyethylene Inserts Thinner than Eight-millimeters Be Utilized in Total Knee Arthroplasty?

    PubMed

    Sayeed, Siraj A; Jauregui, Julio J; Korduba, Laryssa A; Essner, Aaron; Harwin, Steven F; Delanois, Ronald E; Mont, Michael A

    2015-05-01

    The routine use of highly cross-linked ultra-high molecular weight polyethylene (UHMWPE) has remained controversial secondary to the possibility of decreased material properties when compared to conventional UHMWPE. The aim of the present study was to evaluate if thin, sequentially-irradiated, and annealed highly cross-linked UHMWPE tibial inserts would have improved wear properties, while maintaining mechanical integrity, compared to conventional UHMWPE during biomechanical testing under aligned and malaligned conditions. Polyethylene inserts (4.27 and 6.27 mm) manufactured from GUR 1020-UHMWPE were cyclically loaded to analyze for wear. All wear scars were visually examined after loading using scanning electron microscopy (SEM). Volume loss was plotted versus cycle count with linear regression analysis yielding wear rates. There was no statistical difference in wear between both thicknesses for all testing conditions. During aligned condition testing, the volumetric wear rate for sequentially-irradiated and annealed polyethylene thicknesses of 4.27 and 6.27 mm was 4.0 and 4.4 mm3/million cycles; and during malaligned conditions, it was 13.9 and 15.1 mm3/million cycles. For conventional polyethylene during aligned conditions, the volumetric wear rate was 33.0 and 22.8 mm3/million cycles; and during malaligned conditions it was 50.0 and 50.8 mm3/million cycles. By SEM evaluation, condylar wear surfaces for conventional and sequentially-irradiated and annealed polyethylene displayed surface ripples typical of adhesive wear. There were no observed visible differences between the wear scars for conventional compared to sequentially-irradiated and annealed polyethylene with no evidence of fatigue failure. This study demonstrated no differences between polyethylenes with thicknesses of 4.27 and 6.27 mm. This strengthens the conclusion that sequentially-irradiated and annealed highly cross-linked UHMWPE can be utilized in total knee arthroplasty. The successful wear

  17. Modelling the luminosities and sizes of radio sources: radio luminosity function at z = 6

    NASA Astrophysics Data System (ADS)

    Saxena, A.; Röttgering, H. J. A.; Rigby, E. E.

    2017-08-01

    We present a model to predict the luminosity function for radio galaxies and their linear size distribution at any redshift. The model takes a black hole mass function and Eddington ratio distribution as input and tracks the evolution of radio sources, taking into account synchrotron, adiabatic and inverse Compton energy losses. We first test the model at z = 2 where plenty of radio data are available and show that the radio luminosity function (RLF) is consistent with observations. We are able to reproduce the break in luminosity function that separates locally the Fanaroff-Riley class I and Fanaroff-Riley class I radio sources. Our prediction for linear size distribution at z = 2 matches the observed distribution too. We then use our model to predict an RLF and linear size distribution at z = 6, as this is the epoch when radio galaxies can be used as probes of reionization. We demonstrate that higher inverse Compton losses lead to shorter source lifetimes and smaller sizes at high redshifts. The predicted sizes are consistent with the generally observed trend with redshift. We evolve the z = 2 RLF based on observed quasar space densities at high redshifts, and show that our RLF prediction at z = 6 is consistent. Finally, we predict the detection of 0.63, 0.092 and 0.0025 z ≥ 6 sources deg2 at flux density limits of 0.1, 0.5 and 3.5 mJy. We assess the trade-off between coverage area and depth and show that LOFAR surveys with flux density limits of 0.1 and 0.5 mJy are the most efficient at detecting a large number of z ≥ 6 radio sources.

  18. MODELING THE RED SEQUENCE: HIERARCHICAL GROWTH YET SLOW LUMINOSITY EVOLUTION

    SciTech Connect

    Skelton, Rosalind E.; Bell, Eric F.; Somerville, Rachel S.

    2012-07-01

    We explore the effects of mergers on the evolution of massive early-type galaxies by modeling the evolution of their stellar populations in a hierarchical context. We investigate how a realistic red sequence population set up by z {approx} 1 evolves under different assumptions for the merger and star formation histories, comparing changes in color, luminosity, and mass. The purely passive fading of existing red sequence galaxies, with no further mergers or star formation, results in dramatic changes at the bright end of the luminosity function and color-magnitude relation. Without mergers there is too much evolution in luminosity at a fixed space density compared to observations. The change in color and magnitude at a fixed mass resembles that of a passively evolving population that formed relatively recently, at z {approx} 2. Mergers among the red sequence population ('dry mergers') occurring after z = 1 build up mass, counteracting the fading of the existing stellar populations to give smaller changes in both color and luminosity for massive galaxies. By allowing some galaxies to migrate from the blue cloud onto the red sequence after z = 1 through gas-rich mergers, younger stellar populations are added to the red sequence. This manifestation of the progenitor bias increases the scatter in age and results in even smaller changes in color and luminosity between z = 1 and z = 0 at a fixed mass. The resultant evolution appears much slower, resembling the passive evolution of a population that formed at high redshift (z {approx} 3-5), and is in closer agreement with observations. We conclude that measurements of the luminosity and color evolution alone are not sufficient to distinguish between the purely passive evolution of an old population and cosmologically motivated hierarchical growth, although these scenarios have very different implications for the mass growth of early-type galaxies over the last half of cosmic history.

  19. Modeling the Red Sequence: Hierarchical Growth yet Slow Luminosity Evolution

    NASA Astrophysics Data System (ADS)

    Skelton, Rosalind E.; Bell, Eric F.; Somerville, Rachel S.

    2012-07-01

    We explore the effects of mergers on the evolution of massive early-type galaxies by modeling the evolution of their stellar populations in a hierarchical context. We investigate how a realistic red sequence population set up by z ~ 1 evolves under different assumptions for the merger and star formation histories, comparing changes in color, luminosity, and mass. The purely passive fading of existing red sequence galaxies, with no further mergers or star formation, results in dramatic changes at the bright end of the luminosity function and color-magnitude relation. Without mergers there is too much evolution in luminosity at a fixed space density compared to observations. The change in color and magnitude at a fixed mass resembles that of a passively evolving population that formed relatively recently, at z ~ 2. Mergers among the red sequence population ("dry mergers") occurring after z = 1 build up mass, counteracting the fading of the existing stellar populations to give smaller changes in both color and luminosity for massive galaxies. By allowing some galaxies to migrate from the blue cloud onto the red sequence after z = 1 through gas-rich mergers, younger stellar populations are added to the red sequence. This manifestation of the progenitor bias increases the scatter in age and results in even smaller changes in color and luminosity between z = 1 and z = 0 at a fixed mass. The resultant evolution appears much slower, resembling the passive evolution of a population that formed at high redshift (z ~ 3-5), and is in closer agreement with observations. We conclude that measurements of the luminosity and color evolution alone are not sufficient to distinguish between the purely passive evolution of an old population and cosmologically motivated hierarchical growth, although these scenarios have very different implications for the mass growth of early-type galaxies over the last half of cosmic history.

  20. THE z = 5 QUASAR LUMINOSITY FUNCTION FROM SDSS STRIPE 82

    SciTech Connect

    McGreer, Ian D.; Fan Xiaohui; Jiang Linhua; Richards, Gordon T.; Strauss, Michael A.; Ross, Nicholas P.; White, Martin; Shen Yue; Schneider, Donald P.; Brandt, W. Niel; Myers, Adam D.; DeGraf, Colin; Glikman, Eilat; Ge Jian; Streblyanska, Alina

    2013-05-10

    We present a measurement of the Type I quasar luminosity function at z = 5 using a large sample of spectroscopically confirmed quasars selected from optical imaging data. We measure the bright end (M{sub 1450} < -26) with Sloan Digital Sky Survey (SDSS) data covering {approx}6000 deg{sup 2}, then extend to lower luminosities (M{sub 1450} < -24) with newly discovered, faint z {approx} 5 quasars selected from 235 deg{sup 2} of deep, coadded imaging in the SDSS Stripe 82 region (the celestial equator in the Southern Galactic Cap). The faint sample includes 14 quasars with spectra obtained as ancillary science targets in the SDSS-III Baryon Oscillation Spectroscopic Survey, and 59 quasars observed at the MMT and Magellan telescopes. We construct a well-defined sample of 4.7 < z < 5.1 quasars that is highly complete, with 73 spectroscopic identifications out of 92 candidates. Our color selection method is also highly efficient: of the 73 spectra obtained, 71 are high-redshift quasars. These observations reach below the break in the luminosity function (M{sub 1450}{sup *}{approx}-27). The bright-end slope is steep ({beta} {approx}< -4), with a constraint of {beta} < -3.1 at 95% confidence. The break luminosity appears to evolve strongly at high redshift, providing an explanation for the flattening of the bright-end slope reported previously. We find a factor of {approx}2 greater decrease in the number density of luminous quasars (M{sub 1450} < -26) from z = 5 to z = 6 than from z = 4 to z = 5, suggesting a more rapid decline in quasar activity at high redshift than found in previous surveys. Our model for the quasar luminosity function predicts that quasars generate {approx}30% of the ionizing photons required to keep hydrogen in the universe ionized at z = 5.

  1. A complete X-ray sample of the high-latitude /absolute value of b greater than 20 deg/ sky from HEAO 1 A-2 - Log N-log S and luminosity functions

    NASA Technical Reports Server (NTRS)

    Piccinotti, G.; Mushotzky, R. F.; Boldt, E. A.; Holt, S. S.; Marshall, F. E.; Serlemitsos, P. J.; Shafer, R. A.

    1982-01-01

    An all-sky survey of X-ray sources was performed, complete to a limiting sensitivity of 3.1 x 10 to the -11 ergs/sq cm/s in the 2-10 keV band. The complete sample has allowed construction of luminosity functions based on a flux-limited sample for clusters of galaxies and active galactic nuclei. Integration of the best-fit luminosity functions indicates that clusters of galaxies contribute about 4% of the 2-10 keV DXRB, and active galactic nuclei about 20%. It is predicted that many of the objects seen in the deep survey should be local, relatively low luminosity active galactic nuclei and clusters of galaxies.

  2. Multipurpose Transposon-Insertion Libraries in Yeast.

    PubMed

    Kumar, Anuj

    2016-06-01

    Libraries of transposon-insertion alleles constitute powerful and versatile tools for large-scale analysis of yeast gene function. Transposon-insertion libraries are constructed most simply through mutagenesis of a plasmid-based genomic DNA library; modification of the mutagenizing transposon by incorporation of yeast selectable markers, recombination sites, and an epitope tag enables the application of insertion alleles for phenotypic screening and protein localization. In particular, yeast genomic DNA libraries have been mutagenized with modified bacterial transposons carrying the URA3 marker, lox recombination sites, and sequence encoding multiple copies of the hemagglutinin (HA) epitope. Mutagenesis with these transposons has yielded a large resource of insertion alleles affecting nearly 4000 yeast genes in total. Through well-established protocols, these insertion libraries can be introduced into the desired strain backgrounds and the resulting insertional mutants can be screened or systematically analyzed. Relative to alternative methods of UV irradiation or chemical mutagenesis, transposon-insertion alleles can be easily identified by PCR-based approaches or high-throughput sequencing. Transposon-insertion libraries also provide a cost-effective alternative to targeted deletion approaches, although, in contrast to start-codon to stop-codon deletions, insertion alleles might not represent true null-mutants. For protein-localization studies, transposon-insertion alleles can provide encoded epitope tags in-frame with internal codons; in many cases, these transposon-encoded epitope tags can provide a more accurate localization for proteins in which terminal sequences are crucial for intracellular targeting. Thus, overall, transposon-insertion libraries can be used quickly and economically and have a particular utility in screening for desired phenotypes and localization patterns in nonstandard genetic backgrounds. © 2016 Cold Spring Harbor Laboratory Press.

  3. The Local [C ii] 158 μm Emission Line Luminosity Function

    NASA Astrophysics Data System (ADS)

    Hemmati, Shoubaneh; Yan, Lin; Diaz-Santos, Tanio; Armus, Lee; Capak, Peter; Faisst, Andreas; Masters, Daniel

    2017-01-01

    We present, for the first time, the local [C ii] 158 μm emission line luminosity function measured using a sample of more than 500 galaxies from the Revised Bright Galaxy Sample. [C ii] luminosities are measured from the Herschel PACS observations of the Luminous Infrared Galaxies (LIRGs) in the Great Observatories All-sky LIRG Survey and estimated for the rest of the sample based on the far-infrared (far-IR) luminosity and color. The sample covers 91.3% of the sky and is complete at S60 μm > 5.24 Jy. We calculate the completeness as a function of [C ii] line luminosity and distance, based on the far-IR color and flux densities. The [C ii] luminosity function is constrained in the range ∼107–9 L⊙ from both the 1/Vmax and a maximum likelihood methods. The shape of our derived [C ii] emission line luminosity function agrees well with the IR luminosity function. For the CO(1-0) and [C ii] luminosity functions to agree, we propose a varying ratio of [C ii]/CO(1-0) as a function of CO luminosity, with larger ratios for fainter CO luminosities. Limited [C ii] high-redshift observations as well as estimates based on the IR and UV luminosity functions are suggestive of an evolution in the [C ii] luminosity function similar to the evolution trend of the cosmic star formation rate density. Deep surveys using the Atacama Large Millimeter Array with full capability will be able to confirm this prediction.

  4. Fast high-throughput screening of angiotensin-converting enzyme insertion/deletion polymorphism by variable programmed electric field strength-based microchip electrophoresis.

    PubMed

    Sun, Yucheng; Kim, Su-Kang; Zhang, Peng; Woo, Nain; Kang, Seong Ho

    2016-08-15

    An insertion (I)/deletion (D) polymorphism in angiotensin-converting enzyme (ACE) has been associated with susceptibility to various diseases in numerous studies. Traditionally, slab gel electrophoresis (SGE) after polymerase chain reaction (PCR) has been used to genotype this ACE I/D polymorphism. In this study, single- and multi-channel microchip electrophoresis (ME) methods based on variable programmed electric field strength (PEFS) (i.e., low constant, high constant, (+)/(-) staircase, and random electric field strengths) were developed for fast high-throughput screening of this specific polymorphism. The optimum PEFS conditions were set as 470V/cm for 0-9s, 129V/cm for 9-13s, 470V/cm for 13-13.9s, 294V/cm for 13.9-16s, and 470V/cm for 16-20s for single-channel ME, and 615V/cm for 0-22.5s, 231V/cm for 22.5-28.5s, and 615V/cm for 28.5-40s for multi-channel ME, respectively. In the multi-channel PEFS-ME, target ACE I/D polymorphism DNA fragments (D=190bp and I=490bp) were identified within 25s without loss of resolving power, which was ∼300 times faster than conventional SGE. In addition, PCR products of the ACE gene from human blood samples were detected after only 10 cycles by multi-channel PEFS-ME, but not by SGE. This parallel detection multichannel-based PEFS-ME method offers a powerful tool for fast high-throughput ACE I/D polymorphism screening with high sensitivity. Copyright © 2016 Elsevier B.V. All rights reserved.

  5. Luminosity Limitations of Linear Colliders Based on Plasma Acceleration

    SciTech Connect

    Lebedev, Valeri; Burov, Alexey; Nagaitsev, Sergei

    2016-01-01

    Particle acceleration in plasma creates a possibility of exceptionally high accelerating gradients and appears as a very attractive option for future linear electron-positron and/or photon-photon colliders. These high accelerating gradients were already demonstrated in a number of experiments. Furthermore, a linear collider requires exceptionally high beam brightness which still needs to be demonstrated. In this article we discuss major phenomena which limit the beam brightness of accelerated beam and, consequently, the collider luminosity.

  6. High-resolution mapping and chromosome landing at the root-know nematode resistance locus Ma from Myrobalan plum using a large-insert BAC DNA library.

    PubMed

    Claverie, M; Dirlewanger, E; Cosson, P; Bosselut, N; Lecouls, A C; Voisin, R; Kleinhentz, M; Lafargue, B; Caboche, M; Chalhoub, B; Esmenjaud, D

    2004-10-01

    The Ma gene for root-knot nematode (RKN)resistance from Myrobalan plum (Prunus cerasifera L.)confers a complete-spectrum and a heat-stable resistance to Meloidogvne spp., conversely to Mi-I from tomato,which has a more restricted spectrum and a reduced efficiency at high temperature. This gene was identified from a perennial self-incompatible near-wild rootstock species and lies in cosegregation with the SCAR marker SCAFLP2 on the Prunus linkage group 7 in a 2.3 cM interval between the SCAR SCAL19 and SSR pchgms6 markers. We initiated a map-based cloning of Ma and report here the strategy that rapidly led to fine mapping and direct chromosome landing at the locus. Three pairs of bulks, totaling 90 individuals from half-sibling progenies derived from the Ma-heterozygous resistant accession P.2175, were constructed using mapping data, and saturation of the Ma region was performed by bulked segregant analysis (BSA) of 320 AFLP primer pair combinations. The closest three AFLP markers were transformed into codominant SCARs or CAPS designatedSCAFLP3, SCAFLP4 and SCAFLP5. By completing the mapping population up to 1,332 offspring from P.2175,Ma and SCAFLP2 were mapped in a 0.8 cM interval between SCAFLP3 and SCAFLP4. A large-insert bacterial artificial chromosome (BAC) DNA library of P.2175,totaling 30,720 clones with a mean insert size of 145 kb and a 14-15x Prunus haploid genome coverage was constructed and used to land on the Ma spanning interval with few BAC clones. As P.2175 is heterozygous for the gene, we constructed the resistant and susceptible physical contigs by PCR screening of the library with codominant markers. Additional microsatellite markers were then designed from BAC subcloning or BAC end sequencing. In the resistant contig, a single 280 kb BAC clone was shown to carry the Ma gene; this BAC contains two flanking markers on each side of the gene as well as two cosegregating markers. These results should allow future cloning of the Ma gene in this

  7. Highly efficient inverted organic light emitting diodes by inserting a zinc oxide/polyethyleneimine (ZnO:PEI) nano-composite interfacial layer

    NASA Astrophysics Data System (ADS)

    Kaçar, Rifat; Pıravadılı Mucur, Selin; Yıldız, Fikret; Dabak, Salih; Tekin, Emine

    2017-06-01

    The electrode/organic interface is one of the key factors in attaining superior device performance in organic electronics, and inserting a tailor-made layer can dramatically modify its properties. The use of nano-composite (NC) materials leads to many advantages by combining materials with the objective of obtaining a desirable combination of properties. In this context, zinc oxide/polyethyleneimine (ZnO:PEI) NC film was incorporated as an interfacial layer into inverted bottom-emission organic light emitting diodes (IBOLEDs) and fully optimized. For orange-red emissive MEH-PPV based IBOLEDs, a high power efficiency of 6.1 lm W-1 at a luminance of 1000 cd m-2 has been achieved. Notably, the external quantum efficiency (EQE) increased from 0.1 to 4.8% and the current efficiency (CE) increased from 0.2 to 8.7 cd A-1 with rise in luminance (L) from 1000 to above 10 000 cd m-2 levels when compared to that of pristine ZnO-based devices. An identical device architecture containing a ZnO:PEI NC layer has also been used to successfully fabricate green and blue emissive IBOLEDs. The significant enhancement in the inverted device performance, in terms of luminance and efficiency, is attributed to a good energy-level alignment between the cathode/organic interface which leads to effective carrier balance, resulting in efficient radiative-recombination.

  8. The effects of insertion method and force on hand clearance envelopes for rubber hose insertion tasks.

    PubMed

    Grieshaber, D Christian; Armstrong, Thomas J; Chaffin, Don B; Keyserling, W Monroe; Ashton-Miller, James

    2009-04-01

    The aim of this study was to determine how hand space for manual insertion of flexible hoses is affected by insertion method and force. Adequate space is needed during assembly tasks in which workers join parts together with their hands. Hose installations are an example of such a task. Hand clearance envelopes for insertion tasks that involve cylindrical objects, such as a hose, are currently unavailable in the literature. Participants inserted a flexible 25-mm rubber hose onto a stationary flange using simulated methods similar to those observed in field studies of automotive assembly tasks. Markers placed on the back of the hand and wrists were used to measure postures during the insertion task. Hand clearance envelopes for high-force insertions were significantly larger across methods by an average of 15% for both male (p < .05) and female (p < .01) participants. Rocking insertions resulted in the largest hand clearance envelopes compared with other insertion methods. Rocking and twisting the hose resulted in mean increases in the cross-sectional area of the hand clearance envelopes of 35% and 24%, respectively, compared with the straight push. Differences were significant (p < .05) for male and female participants for both bead height conditions. Both required insertion force and method affect hand clearance envelopes during simulated insertions. These methods can be used by engineers to determine if there is adequate clearance for the hand to grip selected objects.

  9. LUMINOSITY FUNCTIONS OF SPITZER-IDENTIFIED PROTOSTARS IN NINE NEARBY MOLECULAR CLOUDS

    SciTech Connect

    Kryukova, E.; Megeath, S. T.; Allen, T. S.; Gutermuth, R. A.; Pipher, J.; Allen, L. E.; Myers, P. C.; Muzerolle, J.

    2012-08-15

    We identify protostars in Spitzer surveys of nine star-forming (SF) molecular clouds within 1 kpc: Serpens, Perseus, Ophiuchus, Chamaeleon, Lupus, Taurus, Orion, Cep OB3, and Mon R2, which combined host over 700 protostar candidates. These clouds encompass a variety of SF environments, including both low-mass and high-mass SF regions, as well as dense clusters and regions of sparsely distributed star formation. Our diverse cloud sample allows us to compare protostar luminosity functions in these varied environments. We combine near- and mid-infrared photometry from the Two Micron All Sky Survey and Spitzer to create 1-24 {mu}m spectral energy distributions (SEDs). Using protostars from the c2d survey with well-determined bolometric luminosities, we derive a relationship between bolometric luminosity, mid-IR luminosity (integrated from 1-24 {mu}m), and SED slope. Estimations of the bolometric luminosities for protostar candidates are combined to create luminosity functions for each cloud. Contamination due to edge-on disks, reddened Class II sources, and galaxies is estimated and removed from the luminosity functions. We find that luminosity functions for high-mass SF clouds (Orion, Mon R2, and Cep OB3) peak near 1 L{sub Sun} and show a tail extending toward luminosities above 100 L{sub Sun }. The luminosity functions of the low-mass SF clouds (Serpens, Perseus, Ophiuchus, Taurus, Lupus, and Chamaeleon) do not exhibit a common peak, however the combined luminosity function of these regions peaks below 1 L{sub Sun }. Finally, we examine the luminosity functions as a function of the local surface density of young stellar objects. In the Orion molecular clouds, we find a significant difference between the luminosity functions of protostars in regions of high and low stellar density, the former of which is biased toward more luminous sources. This may be the result of primordial mass segregation, although this interpretation is not unique. We compare our luminosity

  10. Descemet's Stripping Automated Endothelial Keratoplasty Tissue Insertion Devices

    PubMed Central

    Khan, Salman Nasir; Shiakolas, Panos S.; Mootha, Venkateswara Vinod

    2015-01-01

    This review study provides information regarding the construction, design, and use of six commercially available endothelial allograft insertion devices applied for Descemet's stripping automated endothelial keratoplasty (DSAEK). We also highlight issues being faced in DSAEK and discuss the methods through which medical devices such as corneal inserters may alleviate these issues. Inserter selection is of high importance in the DSAEK procedure since overcoming the learning curve associated with the use of an insertion device is a time and energy consuming process. In the present review, allograft insertion devices were compared in terms of design, construction material, insertion technique, dimensions, incision requirements and endothelial cell loss to show their relative merits and capabilities based on available data in the literature. Moreover, the advantages/disadvantages of various insertion devices used for allograft insertion in DSAEK are reviewed and compared. The information presented in this review can be utilized for better selection of an insertion device for DSAEK. PMID:27051492

  11. The correlations of multi-wave band luminosity and BLR luminosity in Fermi 2LAC blazars

    NASA Astrophysics Data System (ADS)

    Wang, Zerui; Xue, Rui; Xie, Zhaohua; Du, Leiming; Yi, Tingfeng; Xu, Yunbing; Liu, Wenguang

    2017-10-01

    We collect a sample of 78 Fermi detected blazars with broad line region (BLR) data and the quasi-simultaneous multi-wave band data. By analyzing the sample, we find: (1) For whole blazar sample, there exist significant correlations between radio, γ-ray luminosity and BLR luminosity. The slope of the best-fit linear regression equation is close to the theoretical value 1. Our results provided another support of jet-disk symbiosis. (2) For FSRQ sample, we find a significant correlation between radio luminosity and optical luminosity, and weaker correlations between X-ray luminosity and radio, optical luminosity. It indicates that the X-ray band radiation mechanism is slightly different from radio and optical bands. The X-ray emission is diluted by inverse Compton scattering (IC). There is a significant correlation between BLR luminosity and γ-ray luminosity, but no correlations between X-ray luminosity and BLR, γ-ray luminosity, which suggests that the seed soft photons are different for IC process. From these results we suggest that the X-ray band emission is diluted by synchrotron self-Compton (SSC) process, γ-ray band emission is produced by external Compton (EC) process.

  12. Unprecedented high-nuclear transition-metal-cluster-substituted heteropolyoxoniobates: synthesis by {V8 } ring insertion into the POM matrix and antitumor activities.

    PubMed

    Shen, Jian-Qiang; Wu, Qiong; Zhang, Ying; Zhang, Zhi-Ming; Li, Yang-Guang; Lu, Ying; Wang, En-Bo

    2014-03-03

    Reactions of hexaniobate with vanadate in the presence of Ni(2+) , Zn(2+) , or Cu(2+) have furnished three high-nuclear vanadium cluster-substituted heteropolyoxoniobates (HPNs): {Ni(en)3 }5 H{V(V) Nb8 V(IV) 8 O44 }⋅9 H2 O (1), (H2 en)Na2 [{Zn(en)2 (Hen)}{Zn(en)2 (H2 O)}2 {PNb8 V(IV) 8 O44 }]⋅11 H2 O (2), and Na{Cu(en)2 }3 {[Cu(en)2 ]2 [PNb8 V(IV) 8 O44 ]}⋅11 H2 O (3) (en=1,2-diaminoethane). Their structures have been determined and characterized by single-crystal X-ray diffraction analysis, thermogravimetric analysis (TGA), and elemental analysis. Structural analysis has revealed that compounds 1-3 contain similar {V8 }-substituted [X(V) Nb8 V(IV) 8 O44 ](11-) (X=P, V) clusters, obtained by inserting a {V8 } ring into tetravacant HPN [XNb8 O36 ](27-) . To the best of our knowledge, compounds 1-3 represent the first high-nuclear vanadium cluster-substituted HPNs, and compound 1 is the largest vanadoniobate cluster yet obtained in HPN chemistry. Nickel and zinc cations have been introduced into HPNs for the first time, which might promise a more diverse set of structures in this family. Antitumor studies have indicated that compounds 1 and 2 exhibit high activity against human gastric cancer SGC-7901 cells, SC-1680 cells, and MG-63 cells. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Insertion device calculations with mathematica

    SciTech Connect

    Carr, R.; Lidia, S.

    1995-02-01

    The design of accelerator insertion devices such as wigglers and undulators has usually been aided by numerical modeling on digital computers, using code in high level languages like Fortran. In the present era, there are higher level programming environments like IDL{reg_sign}, MatLab{reg_sign}, and Mathematica{reg_sign} in which these calculations may be performed by writing much less code, and in which standard mathematical techniques are very easily used. The authors present a suite of standard insertion device modeling routines in Mathematica to illustrate the new techniques. These routines include a simple way to generate magnetic fields using blocks of CSEM materials, trajectory solutions from the Lorentz force equations for given magnetic fields, Bessel function calculations of radiation for wigglers and undulators and general radiation calculations for undulators.

  14. A novel eight amino acid insertion contributes to the hemagglutinin cleavability and the virulence of a highly pathogenic avian influenza A (H7N3) virus in mice

    SciTech Connect

    Sun, Xiangjie; Belser, Jessica A.; Tumpey, Terrence M.

    2016-01-15

    In 2012, an avian influenza A H7N3 (A/Mexico/InDRE7218/2012; Mx/7218) virus was responsible for two confirmed cases of human infection and led to the death or culling of more than 22 million chickens in Jalisco, Mexico. Interestingly, this virus acquired an 8-amino acid (aa)-insertion (..PENPK-DRKSRHRR-TR/GLF) near the hemagglutinin (HA) cleavage site by nonhomologous recombination with host rRNA. It remains unclear which specific residues at the cleavage site contribute to the virulence of H7N3 viruses in mammals. Using loss-of-function approaches, we generated a series of cleavage site mutant viruses by reverse genetics and characterized the viruses in vitro and in vivo. We found that the 8-aa insertion and the arginine at position P4 of the Mx/7218 HA cleavage site are essential for intracellular HA cleavage in 293T cells, but have no effect on the pH of membrane fusion. However, we identified a role for the histidine residue at P5 position in viral fusion pH. In mice, the 8-aa insertion is required for Mx/7218 virus virulence; however, the basic residues upstream of the P4 position are dispensable for virulence. Overall, our study provides the first line of evidence that the insertion in the Mx/7218 virus HA cleavage site confers its intracellular cleavability, and consequently contributes to enhanced virulence in mice. - Highlights: • An avian influenza H7N3 virus acquired a unique 8-amino acid (aa) insertion. • The role of specific basic residues in the HA insertion in viral pathogenesis was determined. • In mice, the 8-aa insertion is required for H7N3 virus virulence. • The R residue at position P4 is essential for HA intracellular cleavage and virus virulence.

  15. Insertion in Persian

    ERIC Educational Resources Information Center

    Kambuziya, Aliyeh Kord-e Zafaranlu; Dehghan, Masoud

    2011-01-01

    This paper investigates epenthesis process in Persian to catch some results in relating to vowel and consonant insertion in Persian lexicon. This survey has a close relationship to the description of epenthetic consonants and the conditions in which these consonants are used. Since no word in Persian may begin with a vowel, so that hiatus can't be…

  16. MELFI Sample Insertion

    NASA Image and Video Library

    2010-06-28

    ISS024-E-006699 (28 June 2010) --- NASA astronaut Doug Wheelock, Expedition 24 flight engineer, prepares to insert biological samples into trays in the Minus Eighty Laboratory Freezer for ISS-2 (MELFI-2) in the Destiny laboratory of the International Space Station.

  17. MELFI Sample Insertion

    NASA Image and Video Library

    2010-07-02

    ISS024-E-007346 (2 July 2010) --- NASA astronauts Tracy Caldwell Dyson (background) and Shannon Walker, both Expedition 24 flight engineers, prepare to insert biological samples in a dewar tray in the Minus Eighty Laboratory Freezer for ISS (MELFI-1) in the Kibo laboratory of the International Space Station.

  18. MELFI Sample Insertion

    NASA Image and Video Library

    2010-06-28

    ISS024-E-006697 (28 June 2010) --- NASA astronaut Doug Wheelock, Expedition 24 flight engineer, prepares to insert biological samples into trays in the Minus Eighty Laboratory Freezer for ISS-2 (MELFI-2) in the Destiny laboratory of the International Space Station.

  19. The luminosity of Population III star clusters

    NASA Astrophysics Data System (ADS)

    DeSouza, Alexander L.; Basu, Shantanu

    2015-06-01

    We analyse the time evolution of the luminosity of a cluster of Population III protostars formed in the early Universe. We argue from the Jeans criterion that primordial gas can collapse to form a cluster of first stars that evolve relatively independently of one another (i.e. with negligible gravitational interaction). We model the collapse of individual protostellar clumps using non-axisymmetric numerical hydrodynamics simulations. Each collapse produces a protostar surrounded by a massive disc (i.e. Mdisc /M* ≳ 0.1), whose evolution we follow for a further 30-40 kyr. Gravitational instabilities result in the fragmentation and the formation of gravitationally bound clumps within the disc. The accretion of these fragments by the host protostar produces accretion and luminosity bursts on the order of 106 L⊙. Within the cluster, we show that a simultaneity of such events across several protostellar cluster members can elevate the cluster luminosity to 5-10 times greater than expected, and that the cluster spends ˜15 per cent of its star-forming history at these levels. This enhanced luminosity effect is particularly enabled in clusters of modest size with ≃10-20 members. In one such instance, we identify a confluence of burst events that raise the luminosity to nearly 1000 times greater than the cluster mean luminosity, resulting in L > 108 L⊙. This phenomenon arises solely through the gravitational-instability-driven episodic fragmentation and accretion that characterizes this early stage of protostellar evolution.

  20. Upgrading Luminosity from the Tevatron Through the LHC

    NASA Astrophysics Data System (ADS)

    Peggs, Stephen

    2005-04-01

    Very soon the LHC will push the high energy frontier from 1 TeV to 7 TeV, well beyond present operating experience with the Tevatron. The LHC (with 2 rings) is also expected to raise proton luminosities by about two orders of magnitude, to about 10^34 cm-2sec-1 in its initial configuration. This extrapolation leads to a new regime of Accelerator Physics and Technology challenges. The stored energy in the nominal LHC beam is almost 3 orders of magnitude larger than in the Tevatron. Efficient acceleration up the energy ramp is more difficult and more important. Long range beam-beam collisions become more severe. Luminosity debris power becomes a significant constraint. The U.S. LHC Accelerator Research Program (LARP) is a collaboration of BNL, FNAL, LBNL, and SLAC, working with CERN to address these frontier issues. LARP is also working with CERN on an LHC Interaction Region upgrade, through which the luminosity may be increased even further, to about 10^35cm-2sec-1. This paper discusses the technical issues in extrapolating the energy and luminosity from the Tevatron to the LHC, and describes the programs in place to address them.

  1. Luminosity Function of Faint Globular Clusters in M87

    SciTech Connect

    Waters, Christopher Z.; Zepf, Stephen E.; Lauer, Tod R.; Baltz, Edward A.; Silk, Joseph; /Oxford U.

    2006-07-14

    We present the luminosity function to very faint magnitudes for the globular clusters in M87, based on a 30 orbit Hubble Space Telescope (HST) WFPC2 imaging program. The very deep images and corresponding improved false source rejection allow us to probe the mass function further beyond the turnover than has been done before. We compare our luminosity function to those that have been observed in the past, and confirm the similarity of the turnover luminosity between M87 and the Milky Way. We also find with high statistical significance that the M87 luminosity function is broader than that of the Milky Way. We discuss how determining the mass function of the cluster system to low masses can constrain theoretical models of the dynamical evolution of globular cluster systems. Our mass function is consistent with the dependence of mass loss on the initial cluster mass given by classical evaporation, and somewhat inconsistent with newer proposals that have a shallower mass dependence. In addition, the rate of mass loss is consistent with standard evaporation models, and not with the much higher rates proposed by some recent studies of very young cluster systems. We also find that the mass-size relation has very little slope, indicating that there is almost no increase in the size of a cluster with increasing mass.

  2. Status and Outlook for the RHIC Luminosity Upgrade

    NASA Astrophysics Data System (ADS)

    Bai, Mei

    2010-02-01

    As the world highest energy heavy ion collider, the Relativistic Heavy Ion Collider (RHIC) at Brookhaven National Laboratory has been the center for exploring the universe at its infant stage. The operations of RHIC over the past decade has produced many results. A new state of matter, the quark-gluon plasma which is believed to only have existed right after the birth of the universe, was first observed at RHIC during the collisions of Au ions. The experimental data also revealed that this new state of matter behaves like a perfect fluid. In addition to the heavy ion program, RHIC is also capable to accelerate polarized proton beams to high energy, which allows one to explore the spin structure of polarized protons. Both the heavy ion program and spin physics program require high luminosities at RHIC. Various efforts aimed at increasing the RHIC luminosity of heavy ion and polarized proton collisions, such as NEG coating beam pipes to reduce electron clouds, using intrabeam scattering lattice for heavy ion operations as well as longitudinal stochastic cooling. The average store luminosity of Au collisions at a beam energy of 100 GeV/u has reached 1027cm-2s-1. The average store luminosity of RHIC polarized proton collisions at a beam energy of 100 GeV reached 28x1030cm-2s-1 and 55x1030 cm-2s-1 for the polarized proton collisions at a beam energy 250 GeV. Currently, the luminosity is limited by beam-beam effects for polarized proton collisions and intrabeam scattering for heavy ion collisions. Novel techniques are explored and under development to address these issues. The addition of transverse stochastic cooling will minimize the beam size growth due to intrabeam scattering and increase the heavy ion luminosity lifetime. The technique of using 9MHz cavity to accelerate polarized protons minimizes the electron cloud effect, which can cause emittance blowup. It also helps to preserve the longitudinal emittance and yields shorter bunches. The technique of employing an

  3. Bolometric Luminosities of 3 New Bright Lensed Galaxies

    NASA Astrophysics Data System (ADS)

    Rigby, Jane; Chen, Hsiao-Wen; Gladders, Mike; Papovich, Casey

    2008-08-01

    We propose DDT observations of three recently--discovered, very bright, lensed galaxies. We propose IRAC, 24, and 70 um photometry and IRS LL1 spectra for SDSS1226+2152, an extremely bright UV--selected galaxy at z=2.93. Because this galaxy is a full magnitude brighter in g-band than cB58 (the longstanding Rosetta Stone), its optical spectrum provides a resolved, high-S/N window into stellar populations, star formation, and star formation history at high redshift. Spitzer observations will constrain the stellar mass, measure the bolometric luminosity, and measure the 7.7um aromatic luminosity. Because this galaxy was not discovered until Jan 2008, it could not have been proposed in Cycle 5. We also propose 70um photometry for two UV-selected lensed galaxies at z=1.7 and z=2.73, RCS0327-1326 and SDSS1527+0652. These galaxies were discovered in late 2007. Photometry at 70um will measure the bolometric luminosities of these three galaxies. LL1 spectroscopy for S1226 will accurately measure the 7.7um aromatic luminosity. Together, these observations will enable us to: * determine the spectral energy distributions of Lyman break galaxies; * test whether the strange SED of cB58 is anomalous or typical; * test whether the aromatic--to--bolometric luminosity ratios of these galaxies evolve with redshift (as do IR--selected lensed galaxies); compare near-IR, mid-IR, and optical diagnostics of star formation rate; * and work to understand the relationship between IR--selected and UV--selected star--forming galaxies.

  4. Highly sensitive detection of a HER2 12-base pair duplicated insertion mutation in lung cancer using the Eprobe-PCR method

    PubMed Central

    Takase, Yoshiaki; Usui, Kengo; Shimizu, Kimihiro; Kimura, Yasumasa; Ichihara, Tatsuo; Ohkawa, Takahiro; Atsumi, Jun; Enokida, Yasuaki; Nakazawa, Seshiru; Obayashi, Kai; Ohtaki, Yoichi; Nagashima, Toshiteru; Mitani, Yasumasa; Takeyoshi, Izumi

    2017-01-01

    Somatic mutation in human epidermal growth factor receptor-related 2 gene (HER2) is one of the driver mutations in lung cancer. HER2 mutations are found in about 2% of lung adenocarcinomas (ADCs). Previous reports have been based mainly on diagnostic screening by Sanger sequencing or next-generation sequencing (NGS); however, these methods are time-consuming and complicated. We developed a rapid, simple, sensitive mutation detection assay for detecting HER2 12 base pair-duplicated insertion mutation based on the Eprobe-mediated PCR method (Eprobe-PCR) and validated the sensitivity of this assay system for clinical diagnostics. We examined 635 tumor samples and analyzed HER2 mutations using the Eprobe-PCR method, NGS, and Sanger sequencing. In a serial dilution study, the Eprobe-PCR was able to detect mutant plasmid DNA when its concentration was reduced to 0.1% by mixing with wild-type DNA. We also confirmed amplification of the mutated plasmid DNA with only 10 copies per reaction. In ADCs, Eprobe-PCR detected the HER2 mutation in 2.02% (9/446), while Sanger sequencing detected it in 1.57% (7/446). Eprobe-PCR was able to detect the mutation in two samples that were undetectable by Sanger sequencing. All non-ADC samples were wild-type. There were no discrepancies between frozen and formalin-fixed paraffin-embedded tissues in the nine samples. HER2 mutations detected by NGS data validated the high sensitivity of the method. Therefore, this new technique can lead to precise molecular-targeted therapies. PMID:28152008

  5. Highly sensitive detection of a HER2 12-base pair duplicated insertion mutation in lung cancer using the Eprobe-PCR method.

    PubMed

    Takase, Yoshiaki; Usui, Kengo; Shimizu, Kimihiro; Kimura, Yasumasa; Ichihara, Tatsuo; Ohkawa, Takahiro; Atsumi, Jun; Enokida, Yasuaki; Nakazawa, Seshiru; Obayashi, Kai; Ohtaki, Yoichi; Nagashima, Toshiteru; Mitani, Yasumasa; Takeyoshi, Izumi

    2017-01-01

    Somatic mutation in human epidermal growth factor receptor-related 2 gene (HER2) is one of the driver mutations in lung cancer. HER2 mutations are found in about 2% of lung adenocarcinomas (ADCs). Previous reports have been based mainly on diagnostic screening by Sanger sequencing or next-generation sequencing (NGS); however, these methods are time-consuming and complicated. We developed a rapid, simple, sensitive mutation detection assay for detecting HER2 12 base pair-duplicated insertion mutation based on the Eprobe-mediated PCR method (Eprobe-PCR) and validated the sensitivity of this assay system for clinical diagnostics. We examined 635 tumor samples and analyzed HER2 mutations using the Eprobe-PCR method, NGS, and Sanger sequencing. In a serial dilution study, the Eprobe-PCR was able to detect mutant plasmid DNA when its concentration was reduced to 0.1% by mixing with wild-type DNA. We also confirmed amplification of the mutated plasmid DNA with only 10 copies per reaction. In ADCs, Eprobe-PCR detected the HER2 mutation in 2.02% (9/446), while Sanger sequencing detected it in 1.57% (7/446). Eprobe-PCR was able to detect the mutation in two samples that were undetectable by Sanger sequencing. All non-ADC samples were wild-type. There were no discrepancies between frozen and formalin-fixed paraffin-embedded tissues in the nine samples. HER2 mutations detected by NGS data validated the high sensitivity of the method. Therefore, this new technique can lead to precise molecular-targeted therapies.

  6. IMPROVED PHOTOMETRIC REDSHIFTS WITH SURFACE LUMINOSITY PRIORS

    SciTech Connect

    Xia Lifang; Cohen, Seth; Malhotra, Sangeeta; Rhoads, James; Grogin, Norman; Windhorst, Rogier A.; Hathi, Nimish P.; Pirzkal, Nor; Xu Chun

    2009-07-15

    We apply Bayesian statistics with prior probabilities of galaxy surface luminosity (SL) to improve photometric redshifts. We apply the method to a sample of 1266 galaxies with spectroscopic redshifts in the GOODS North and South fields at 0.1 {approx}< z {approx}< 2.0. We start with spectrophotometric redshifts (SPZs) based on Probing Evolution and Reionization Spectroscopically grism spectra, which cover a wavelength range of 6000-9000 A, combined with (U)BViz(JHK) broadband photometry in the GOODS fields. The accuracy of SPZ redshifts is estimated to be {sigma}({delta}(z)) = 0.035 with an systematic offset of -0.026, where {delta}(z) = {delta}z/(1 + z), for galaxies in redshift range of 0.5 {approx}< z {approx}< 1.25. The addition of the SL prior probability helps break the degeneracy of SPZ redshifts between low redshift 4000 A break galaxies and high-redshift Lyman break galaxies which are mostly catastrophic outliers. For the 1138 galaxies at z {approx}< 1.6, the fraction of galaxies with redshift deviation {delta}(z)>0.2 is reduced from 15.0% to 10.4%, while the rms scatter of the fractional redshift error does not change much.

  7. Insertion sequence elements in Lactococcus garvieae.

    PubMed

    Eraclio, Giovanni; Ricci, Giovanni; Fortina, Maria Grazia

    2015-01-25

    Insertion sequences are the simplest intracellular Mobile Genetic Elements which can occur in very high numbers in prokaryotic genomes, where they play an important evolutionary role by promoting genome plasticity. As such, the studies on the diversity and distribution of insertion sequences in genomes not yet investigated can contribute to improve the knowledge on a bacterial species and to identify new transposable elements. The present work describes the occurrence of insertion sequences in Lactococcus garvieae, an opportunistic emerging zoonotic and human pathogen, also associated with different food matrices. To date, no insertion elements have been described for L. garvieae in the IS element database. The analysis of the twelve published L. garvieae genomes identified 15 distinct insertion sequences that are members of the IS3, IS982, IS6, IS21 and IS256 families, including five new elements. Most of the insertion sequences in L. garvieae show substantial homology to the Lactococcus lactis elements, suggesting the movement of IS between these two species phylogenetically closely related. ISLL6 elements belonging to IS3 family were most abundant, with several copies distributed in 9 of the 12 genomes analyzed. An alignment analysis of two complete genomes carrying multi-copies of this insertion sequence indicates a possible involvement of ISLL6 in chromosomal rearrangement.

  8. Thought Insertion Clarified

    PubMed Central

    Ratcliffe, Matthew; Wilkinson, Sam

    2016-01-01

    ‘Thought insertion’ in schizophrenia involves somehow experiencing one’s own thoughts as someone else’s. Some philosophers try to make sense of this by distinguishing between ownership and agency: one still experiences oneself as the owner of an inserted thought but attributes it to another agency. In this paper, we propose that thought insertion involves experiencing thought contents as alien, rather than episodes of thinking. To make our case, we compare thought insertion to certain experiences of ‘verbal hallucination’ and show that they amount to different descriptions of the same phenomenon: a quasi-perceptual experience of thought content. We add that the agency/ownership distinction is unhelpful here. What requires explanation is not why a person experiences a type of intentional state without the usual sense of agency, but why she experiences herself as the agent of one type of intentional state rather than another. We conclude by sketching an account of how this might happen. PMID:28123340

  9. Optical Variability of Quasars as a Function of Luminosity and Redshift

    NASA Astrophysics Data System (ADS)

    Gaskell, C. M.; Koratkar, A. P.; Kwon, T.-Y.; Liang, Y.; Scott, J. H.; Wysota, A.

    1987-09-01

    Various models of the "central engine" in quasars make different predictions of how the degree of variability and its timescale vary with luminosity. In the past there have been conflicting claims about the luminosity and redshift dependence of quasar variability. We have examined the photographic light curves obtained at the Rosemary Hill Observatory (U. of Florida) and the Royal Greenwich Observatory (Herstmonceux) for over a hundred quasars (both radio-loud and radio-quiet). We demonstrate how the previously-reported redshift dependence is a consequence of time dilation, and find that, after allowance for this, there is no luminosity dependence in the amplitude of variability. High-luminosity quasars are not less variable than their low-luminosity counterparts. This creates major difficulties for some classes of quasar model with discrete accretion events (e.g., gas cloud or disrupted stars being "swallowed" directly).

  10. The luminosity function of galactic X-ray sources - A cutoff and a 'standard candle'

    NASA Technical Reports Server (NTRS)

    Margon, B.; Ostriker, J. P.

    1973-01-01

    Analysis of the 2- to 10-kev luminosity distribution of 36 X-ray sources in the Local Group having known or estimated distances, showing that there exists a luminosity cutoff of approximately 10 to the 37.7th ergs/sec in agreement with the theoretical (Eddington) limit for the luminosity of an approximately 1 solar mass star. Furthermore, among the complete sample of high-luminosity sources, there appears to be a statistically significant group of X-ray 'standard candles' at (within less than 0.8 mag) the critical luminosity. This finding (which is in agreement with the self-consistent mass flow accretion models) presents the possibility that X-ray sources may be used as extragalactic distance indicators in the next generation of X-ray astronomy experiments.

  11. Effects of extended components of [O iii] on the correlation between the [O iii] luminosity and the power-law continuum luminosity for active galactic nuclei

    NASA Astrophysics Data System (ADS)

    Zhang, Xue-Guang; Feng, Long-Long

    2017-06-01

    In this manuscript, we check the well-known correlation between [O iii] luminosity and continuum luminosity (L_{[O III]}-L_{5100Å} ) for active galactic nuclei (AGN) by a large sample of 1982 Sloan Digital Sky Survey Quasar Stellar Objects (QSOs) with z < 0.8 and with high-quality spectra. The strong correlation of L_{[O III]}-L_{5100Å} can be found, similar as previous results for AGN. Moreover, among the 1982 QSOs, there are 708 QSOs with the [O iii] λ5007 Å described by two components: one core component plus one extended component. Based on the luminosity from the core components (L_{[O III], narrow}) and from the extended components (L_{[O III], ext}), we confirm that the correlation of L_{[O III], ext}-L_{5100Å} is stronger and tighter than the correlations on the total [O iii] luminosity and on the luminosity of the core components of the [O iii] lines. Therefore, the luminosity of the extended components should be better applied to trace AGN intrinsic luminosity. Meanwhile, we have found strong line-width correlation and line luminosity correlation between the core components and the extended components, indicating that the extended components of the [O iii] lines should be not due to commonly considered radial flows in the common [O iii] line clouds. And virial effects due to gravity of central black holes naturally lead to the wider extended components from regions more nearer to central black holes. Finally, we can say that the reported correlation of L_{[O III], narrow}-L_{5100Å} on the core components of the [O iii] lines should be more better to estimate AGN intrinsic luminosity in type-2 narrow-line AGN, because of totally/partly obscured extended components.

  12. DESIGN OF A HIGH COMPRESSION, DIRECT INJECTION, SPARK-IGNITION, METHANOL FUELED RESEARCH ENGINE WITH AN INTEGRAL INJECTOR-IGNITION SOURCE INSERT, SAE PAPER 2001-01-3651

    EPA Science Inventory

    A stratified charge research engine and test stand were designed and built for this work. The primary goal of this project was to evaluate the feasibility of using a removal integral injector ignition source insert which allows a convenient method of charging the relative locat...

  13. DESIGN OF A HIGH COMPRESSION, DIRECT INJECTION, SPARK-IGNITION, METHANOL FUELED RESEARCH ENGINE WITH AN INTEGRAL INJECTOR-IGNITION SOURCE INSERT, SAE PAPER 2001-01-3651

    EPA Science Inventory

    A stratified charge research engine and test stand were designed and built for this work. The primary goal of this project was to evaluate the feasibility of using a removal integral injector ignition source insert which allows a convenient method of charging the relative locat...

  14. Somatic microindels in human cancer: the insertions are highly error-prone and derive from nearby but not adjacent sense and antisense templates

    PubMed Central

    Scaringe, William A.; Li, Kai; Gu, Dongqing; Gonzalez, Kelly D.; Chen, Zhenbin; Hill, Kathleen A.; Sommer, Steve S.

    2008-01-01

    Somatic microindels (microdeletions with microinsertions) have been studied in normal mouse tissues using the Big Blue lacI transgenic mutation detection system. Here we analyze microindels in human cancers using an endogenous and transcribed gene, the TP53 gene. Microindel frequency, the enhancement of 1–2 microindels and other features are generally similar to that observed in the non-transcribed lacI gene in normal mouse tissues. The current larger sample of somatic microindels reveals recurroids: mutations in which deletions are identical and the co-localized insertion is similar. The data reveal that the inserted sequences derive from nearby but not adjacent sequences in contrast to the slippage that characterizes the great majority of pure microinsertions. The microindel inserted sequences derive from a template on the sense or antisense strand with similar frequency. The estimated error rate of the insertion process of 13% per bp is by far the largest reported in vivo, with the possible exception of somatic hypermutation in the immunoglobulin gene. The data constrain possible mechanisms of microindels and raise the question of whether microindels are ‘scars’ from the bypass of large DNA adducts by a translesional polymerase, e.g. the ‘Tarzan model’ presented herein. PMID:18632684

  15. Somatic microindels in human cancer: the insertions are highly error-prone and derive from nearby but not adjacent sense and antisense templates.

    PubMed

    Scaringe, William A; Li, Kai; Gu, Dongqing; Gonzalez, Kelly D; Chen, Zhenbin; Hill, Kathleen A; Sommer, Steve S

    2008-09-15

    Somatic microindels (microdeletions with microinsertions) have been studied in normal mouse tissues using the Big Blue lacI transgenic mutation detection system. Here we analyze microindels in human cancers using an endogenous and transcribed gene, the TP53 gene. Microindel frequency, the enhancement of 1-2 microindels and other features are generally similar to that observed in the non-transcribed lacI gene in normal mouse tissues. The current larger sample of somatic microindels reveals recurroids: mutations in which deletions are identical and the co-localized insertion is similar. The data reveal that the inserted sequences derive from nearby but not adjacent sequences in contrast to the slippage that characterizes the great majority of pure microinsertions. The microindel inserted sequences derive from a template on the sense or antisense strand with similar frequency. The estimated error rate of the insertion process of 13% per bp is by far the largest reported in vivo, with the possible exception of somatic hypermutation in the immunoglobulin gene. The data constrain possible mechanisms of microindels and raise the question of whether microindels are 'scars' from the bypass of large DNA adducts by a translesional polymerase, e.g. the 'Tarzan model' presented herein.

  16. The X-ray luminosity functions of Abell clusters from the Einstein Cluster Survey

    NASA Technical Reports Server (NTRS)

    Burg, R.; Giacconi, R.; Forman, W.; Jones, C.

    1994-01-01

    We have derived the present epoch X-ray luminosity function of northern Abell clusters using luminosities from the Einstein Cluster Survey. The sample is sufficiently large that we can determine the luminosity function for each richness class separately with sufficient precision to study and compare the different luminosity functions. We find that, within each richness class, the range of X-ray luminosity is quite large and spans nearly a factor of 25. Characterizing the luminosity function for each richness class with a Schechter function, we find that the characteristic X-ray luminosity, L(sub *), scales with richness class as (L(sub *) varies as N(sub*)(exp gamma), where N(sub *) is the corrected, mean number of galaxies in a richness class, and the best-fitting exponent is gamma = 1.3 +/- 0.4. Finally, our analysis suggests that there is a lower limit to the X-ray luminosity of clusters which is determined by the integrated emission of the cluster member galaxies, and this also scales with richness class. The present sample forms a baseline for testing cosmological evolution of Abell-like clusters when an appropriate high-redshift cluster sample becomes available.

  17. The Luminosity Measurement for the DZERO Experiment at Fermilab

    SciTech Connect

    Snow, Gregory R.

    2016-08-01

    Primary project objective: The addition of University of Nebraska-Lincoln (UNL) human resources supported by this grant helped ensure that Fermilab’s DZERO experiment had a reliable luminosity measurement through the end of Run II data taking and an easily-accessible repository of luminosity information for all collaborators performing physics analyses through the publication of its final physics results. Secondary project objective: The collaboration between the UNL Instrument Shop and Fermilab’s Scintillation Detector Development Center enhanced the University of Nebraska’s future role as a particle detector R&D and production facility for future high energy physics experiments. Overall project objective: This targeted project enhanced the University of Nebraska’s presence in both frontier high energy physics research in DZERO and particle detector development, and it thereby served the goals of the DOE Office of Science and the Experimental Program to Stimulate Competitive Research (EPSCoR) for the state of Nebraska.

  18. Luminosity, My Dear Watson, Luminosity!-Or, Are Those Bloodstains?

    NASA Astrophysics Data System (ADS)

    Burke, Barbara A.; Golestaneh, Kamran; Samson, Helene

    1999-01-01

    This version of the luminol demonstration illustrates the use of the luminol reaction as a presumptive test for bloodstains. The procedures developed for the demonstration are based on those used by forensic scientists. The high sensitivity of this test can be shown, since blood diluted 1:150 will cause visible luminescence in a darkened room. False-positive results are given by stains of solutions of the transition metal ions, Fe3+, Cu2+, and Co2+. This latter part of the demonstration illustrates the importance of confirmatory tests in qualitative chemical analyses. A two-reservoir spray bottle was constructed and used in this demonstration. This demonstration requires relatively small amounts of materials and therefore significantly reduces the amount of hazardous waste generated.

  19. LHC Abort Gap Cleaning Studies During Luminosity Operation

    SciTech Connect

    Gianfelice-Wendt, E.; Bartmann, W.; Boccardi, A.; Bracco, C.; Bravin, E.; Goddard, B.; Hofle, W.; Jacquet, D.; Jeff, A.; Kain, V.; Meddahi, M.; /CERN

    2012-05-11

    The presence of significant intensities of un-bunched beam is a potentially serious issue in the LHC. Procedures using damper kickers for cleaning both the Abort Gap (AG) and the buckets targeted for injection, are currently in operation at flat bottom. Recent observations of relatively high population of the AG during physics runs brought up the need for AG cleaning during luminosity operation. In this paper the results of experimental studies performed in October 2011 are presented.

  20. Correlation function of the luminosity distances

    NASA Astrophysics Data System (ADS)

    Biern, Sang Gyu; Yoo, Jaiyul

    2017-09-01

    We present the correlation function of the luminosity distances in a flat ΛCDM universe. Decomposing the luminosity distance fluctuation into the velocity, the gravitational potential, and the lensing contributions in linear perturbation theory, we study their individual contributions to the correlation function. The lensing contribution is important at large redshift (z gtrsim 0.5) but only for small angular separation (θ lesssim 3°), while the velocity contribution dominates over the other contributions at low redshift or at larger separation. However, the gravitational potential contribution is always subdominant at all scale, if the correct gauge-invariant expression is used. The correlation function of the luminosity distances depends significantly on the matter content, especially for the lensing contribution, thus providing a novel tool of estimating cosmological parameters.

  1. Apparent luminosity of solar power satellites

    NASA Technical Reports Server (NTRS)

    Livingston, L. E.

    1980-01-01

    The objective of this investigation was a quantitative characterization of solar power satellite luminosity as seen from the earth. The reflective characteristics of the reference photovoltaic satellite configurations are defined. Diffuse reflection from a single satellite will, at maximum, fall between magnitudes -4 and -5. A 60-satellite fleet will have a maximum total luminosity equivalent to a single object of magnitude -9. Specular reflections from the array and antenna will be of magnitude -12 to -15, but visible only occasionally for about 2 minutes at a given location. Methods of preventing specular reflections from striking the earth are presented. Thermal cycle power conversion systems are discussed qualitatively as a means of reducing diffuse luminosity.

  2. Radio luminosity function of brightest cluster galaxies

    NASA Astrophysics Data System (ADS)

    Yuan, Z. S.; Han, J. L.; Wen, Z. L.

    2016-08-01

    By cross-matching the currently largest optical catalogue of galaxy clusters and the NVSS radio survey data base, we obtain a large complete sample of brightest cluster galaxies (BCGs) in the redshift range of 0.05 < z ≤ 0.45, which have radio emission and redshift information. We confirm that more powerful radio BCGs tend to be these optically very bright galaxies located in more relaxed clusters. We derived the radio luminosity functions of the largest sample of radio BCGs, and find that the functions depend on the optical luminosity of BCGs and the dynamic state of galaxy clusters. However, the radio luminosity function does not show significant evolution with redshift.

  3. Luminosity Function Statistics Applied in GRB Samples

    NASA Astrophysics Data System (ADS)

    Lemos, Luis Juracy Rangel; Bianco, Carlo L.; Ruffini, Remo

    The luminosity function (LF) statistics applied in data of GRBs detected by GBM/Fermi and BAT/Swift is the theme approached in this work. The LF is a strong statistical tool to extract useful information from astrophysical samples, and the key point of this statistical analysis is in the detector sensitivity, where we have performed careful analysis. We produced, by LF statistics, the GRB predicted distributions of: peak ux N(Fpk), redshift N(z) and peak luminosity N(Lpk). We also used different GRB rates. We performed a comparison between the distributions predicted and observed (with and without redshifts), where we had to build a list with more then 250 GRBs with known redshifts. We estimated the effects of the Malmquist bias in all samples, and we looked for a correlation between the isotropic luminosity and the Band peak spectral energy.

  4. Stellar luminosity variations and global warming.

    PubMed

    Foukal, P

    1994-04-08

    Recent studies indicate that variation in the sun's luminosity is less than that observed in many other stars of similar magnetic activity. Current findings also indicate that in more active stars, the attenuation by faculae of sunspot luminosity modulation is less effective than in the sun at present. The sun could thus become photometrically more variable (and dimmer) if its magnetic activity exceeded present levels. But the levels of solar activity required for this to occur are not observed in carbon-14 and beryllium-10 records over the past several millennia, which indicates that such an increase in amplitude of surface magnetism-driven variations in solar luminosity is unlikely in the present epoch.

  5. Radius-luminosity and mass-luminosity relationships for active galactic nuclei

    NASA Technical Reports Server (NTRS)

    Koratkar, Anuradha P.; Gaskell, C. Martin

    1991-01-01

    Broad-line region (BLR) sizes derived from spectral variability and BLR line widths are used to directly derive the mass (M) of the central objects of ten active galactic nuclei (AGNs) in a uniform manner. It is shown that the luminosity-weighted C IV 1549-emitting BLR radius (R) correlates with the bolometric luminosity L(Bol) and is consistent with R about sq rt L(Bol). The measurements also permit a verification of the Dibai mass-luminosity (M-L) relationship (previously derived indirectly). It is found that L(Bol) is proportional to M exp (1.1 + or - 0.3). It is found that the efficiency factor epsilon, defined as the ratio of L(Bol) to the Eddington luminosity increases from 0.03 in the low-luminosity Seyferts up to 0.06 in the most luminous objects in the sample.

  6. Estimation of insertion depth angle based on cochlea diameter and linear insertion depth: a prediction tool for the CI422.

    PubMed

    Franke-Trieger, Annett; Mürbe, Dirk

    2015-11-01

    Beside the cochlear size, the linear insertion depth (LID) influences the insertion depth angle of cochlear implant electrode arrays. For the specific implant CI422 the recommended LID is not fixed but can vary continuously between 20 and 25 mm. In the current study, the influence of cochlea size and LID on the final insertion depth angle was investigated to develop a prediction tool for the insertion depth angle by means of cochlea diameter and LID. Preoperative estimation of insertion depth angles might help surgeons avoid exceeding an intended insertion depth, especially with respect to low-frequency residual hearing preservation. Postoperative, high-resolution 3D-radiographs provided by Flat Panel Computed Volume Tomography (FPCT) were used to investigate the insertion depth angle in 37 CI422 recipients. Furthermore, the FPCT images were used to measure linear insertion depth and diameter of the basal turn of the cochlea. A considerable variation of measured insertion depth angles ranging from 306° to 579° was identified. The measured linear insertion depth ranged from -18.6 to 26.2 mm and correlated positively with the insertion depth angle. The cochlea diameter ranged from 8.11 to 10.42 mm and correlated negatively with the insertion depth angle. The results suggest that preoperatively measured cochlea diameter combined with the option of different array positions by means of LID may act as predictors for the final insertion depth angle.

  7. Luminosity Functions Of Xxl Clusters Galaxies

    NASA Astrophysics Data System (ADS)

    Ricci, Marina; Maurogordato, Sophie; Benoist, Christophe; XXL Consortium

    2017-06-01

    The galaxy luminosity function (LF) is a powerful statistical tool to investigate galaxy evolution. In particular the study of cluster galaxies LFs gives information about environmental effects and how galaxies populate their parent dark matter halos. In this poster we present our work on the galaxy LF of X-ray detected galaxy clusters from the XXL survey. The sample consists of 173 galaxy groups/clusters spanning a wide range in both mass (M500 from 1013 to 1015 solar masses ) and redshit (0.03 < z < 1.22). The main goal is to investigate the effect of evolution and cluster masses on the luminosity distribution of cluster galaxies.

  8. Multi-wavelength Luminosity Functions of Galaxies

    NASA Technical Reports Server (NTRS)

    Gardner, J. P.; Miller, N. A.

    2002-01-01

    Multivariate or multi-wavelength luminosity functions will reveal the interplay between star formation, chemical evolution, and absorption and re-emission of dust within evolving galaxy populations. By using principal component analysis to reduce the dimensionality of the problem, we optimally extract the relevant photometric information from large galaxy catalogs. As a demonstration of the technique, we derive the multi-wavelength luminosity function for the galaxies in the released SDSS catalog, and compare the results with those obtained by traditional methods. This technique will be applicable to catalogs of galaxies from datasets obtained by 2MASS, and the SIRTF and GALEX missions.

  9. Multi-Wavelength Luminosity Functions of Galaxies

    NASA Technical Reports Server (NTRS)

    Gardner, Jonathan P.

    2002-01-01

    Multivariate or multi-wavelength luminosity functions will reveal the interplay between star formation, chemical evolution, and ab- sorption and re-emission of dust within evolving galaxy populations. By using principal component analysis to reduce the dimensionality of the problem, I optimally extract the relevant photometric information from large galaxy catalogs. As a demonstration of the technique, I derive the multi-wavelength luminosity function for the galaxies in the released SDSS catalog, and compare the results with those obtained by traditional methods. This technique will be applicable to catalogs of galaxies from datasets obtained by 2MASS, and the SIRTF and GALEX missions.

  10. Offline Software for the PANDA Luminosity Detector

    NASA Astrophysics Data System (ADS)

    Karavdina, A.; Denig, A.; Feldbauer, F.; Jasinski, P.; Leithoff, H.; Michel, M.; Motzko, C.; Pflüger, S.; Weber, T.; Fritsch, M.

    2014-06-01

    In 2018 data taking for hadronphysics facility PANDA is planned to commence. It will be build at the antiproton accelerator HESR, which itself is a part of the FAIR complex (GSI, Darmstadt, Germany). The luminosity at PANDA will be measured by a dedicated sub-detector, which will register scattered antiproton tracks from pp elastic scattering. From a software point of view, the Luminosity Detector is a tracking system. Therefore the most of its offline software parts are typical for a track reconstruction. The basic concept and Monte Carlo based performance studies of each reconstruction step is presented in this paper.

  11. Arthroscopic classification of posterior labrum glenoid insertion.

    PubMed

    Nourissat, G; Radier, C; Aim, F; Lacoste, S

    2014-04-01

    We performed a prospective arthroscopic study to explore the variability of the posterior labrum glenoid insertion. We aimed to classify the insertions and to explore whether these insertions can be identified by pre-operative arthro-CT scan. From January to December 2011, 86 patients were prospectively included in the current study. During arthroscopy, anterior labrum was evaluated and posterior labrum was assessed in 3 different locations: superior, medial, and inferior. For each segment, the labrum was considered normally inserted (directly to the glenoid cartilage), medialized (inserted at the posterior part of the glenoid bone, without direct contact with the cartilage), torn (macroscopic degenerative changes, tears, fragments) or absent (agenesis). Imaging was analyzed segment by segment by an experienced osteoarticular radiologist, using the same classification. Four types of posterior labrum insertions were identified. Type 1, 60% of the cases, corresponded to a posterior labrum totally inserted in the glenoid, with direct contact with the cartilage. Type 2, 20% of the cases, represented medialized insertion of the superior segment. Type 3, 15% of the cases, represented an associated medialization of the superior and medial segment of the posterior labrum. Type 4 is a medialized insertion of the all-posterior labrum. Fifty-six shoulders were used for arthro-CT and arthroscopy correlation: for the superior segment (n=22/56), the sensitivity of arthro-CT to identify an abnormal insertion when the labrum is medialized was 68.18%, specificity 70.59%, positive predictive value (PPV) 60%, and negative predictive value (NPV) 77.42%. For the medial segment (n=16/56), the sensitivity of arthro-CT to identify an abnormal insertion when the labrum is medialized was 81.25%, specificity 57.50%, PPV 43.33% and NPV 88.46%. For the inferior segment (n=5/56), the sensitivity was 100%, specificity 47.60%, PPV 15.63% and NPV 100%. The current study points out the high

  12. The VIMOS VLT deep survey. The ultraviolet galaxy luminosity function and luminosity density at 3 ≤ z ≤ 4

    NASA Astrophysics Data System (ADS)

    Paltani, S.; Le Fèvre, O.; Ilbert, O.; Arnouts, S.; Bardelli, S.; Tresse, L.; Zamorani, G.; Zucca, E.; Bottini, D.; Garilli, B.; Le Brun, V.; Maccagni, D.; Picat, J.-P.; Scaramella, R.; Scodeggio, M.; Vettolani, G.; Zanichelli, A.; Adami, C.; Bolzonella, M.; Cappi, A.; Charlot, S.; Ciliegi, P.; Contini, T.; Foucaud, S.; Franzetti, P.; Gavignaud, I.; Guzzo, L.; Iovino, A.; McCracken, H. J.; Marano, B.; Marinoni, C.; Mazure, A.; Meneux, B.; Merighi, R.; Pellò, R.; Pollo, A.; Pozzetti, L.; Radovich, M.; Bondi, M.; Bongiorno, A.; Brinchmann, J.; Cucciati, O.; de la Torre, S.; Lamareille, F.; Mellier, Y.; Merluzzi, P.; Temporin, S.; Vergani, D.; Walcher, C. J.

    2007-03-01

    Aims:We study the luminosity function of the high-redshift galaxy population with redshifts 3≤ z ≤ 4 using a purely I-band magnitude-selected spectroscopic sample obtained in the framework of the VIMOS VLT Deep Survey (VVDS). Methods: We determine the luminosity function from the VVDS, taking care to add as few assumptions and as simple corrections as possible, and compare our results with those obtained from photometric studies, based on Lyman-break selections or photometric-redshift measurements. Results: We find that in the redshift range 3≤ z ≤ 4, the VVDS luminosity function is parameterized by φ^*=1.24+0.48-0.50×10-3 mag-1 Mpc-3 and M^*=-21.49+0.19-0.19, assuming a slope α=-1.4 consistent with most previous studies. While φ* is comparable to previously found values, M* is significantly brighter by about 0.5 mag at least. Using the conservative slope α=-1.4, we find a luminosity density at 1700 Å L1700(M<-18.5)=2.4×1019 W Mpc-3 and L1700Total=3.1×1019 W Mpc-3, comparable to that estimated in other studies. Conclusions: .The unexpectedly large number of very bright galaxies found in the VVDS indicates that the color-selection and photometric-redshift techniques that are generally used to build high-redshift galaxy samples may be affected by a significant fraction of color-measurement failures or by incomplete modelling of the mix of stellar emission, AGN contribution, dust absorption and intergalactic extinction assumed to identify high-redshift galaxies, making pure magnitude selection better able to trace the full population. Because of the difficulty to identify all low-luminosity galaxies in a spectroscopic survey, the luminosity density could still be significantly underestimated. We also find that the relative contribution of the most luminous galaxies compared to the fainter ones is at least twice as large in the VVDS compared to former estimates. Therefore, the VVDS paints a quite different picture of the role of the most actively star

  13. Strength of inserts in titanium alloy machining

    NASA Astrophysics Data System (ADS)

    Kozlov, V.; Huang, Z.; Zhang, J.

    2016-04-01

    In this paper, a stressed state of a non-worn cutting wedge in a machined titanium alloy (Ti6Al2Mo2Cr) is analyzed. The distribution of contact loads on the face of a cutting tool was obtained experimentally with the use of a ‘split cutting tool’. Calculation of internal stresses in the indexable insert made from cemented carbide (WC8Co) was carried out with the help of ANSYS 14.0 software. Investigations showed that a small thickness of the cutting insert leads to extremely high compressive stresses near the cutting edge, stresses that exceed the ultimate compressive strength of cemented carbide. The face and the base of the insert experience high tensile stresses, which approach the ultimate tensile strength of cemented carbide and increase a probability of cutting insert destruction. If the thickness of the cutting insert is bigger than 5 mm, compressive stresses near the cutting edge decrease, and tensile stresses on the face and base decrease to zero. The dependences of the greatest normal and tangential stresses on thickness of the cutting insert were found. Abbreviation and symbols: m/s - meter per second (cutting speed v); mm/r - millimeter per revolution (feed rate f); MPa - mega Pascal (dimension of specific contact loads and stresses); γ - rake angle of the cutting tool [°] α - clearance angle of the sharp cutting tool [°].

  14. Timing of the IUD insertion.

    PubMed

    Edelman, D A; Zipper, J; Rivera, M; Medel, M

    1979-05-01

    The relationship between the time in the menstrual cycle when a TCu-200 or Cu-7-200 is inserted and subsequent IUD-related events was evaluated. For women who had either TCus or Cu-7s inserted, the pregnancy, expulsion and medical removal rates were similar for insertions performed at any time of the menstrual cycle.

  15. The connection between galaxy environment and the luminosity function slopes of star-forming regions

    NASA Astrophysics Data System (ADS)

    Cook, David O.; Dale, Daniel A.; Lee, Janice C.; Thilker, David; Calzetti, Daniela; Kennicutt, Robert C.

    2016-11-01

    We present the first study of GALEX far-ultraviolet (FUV) luminosity functions of individual star-forming regions within a sample of 258 nearby galaxies spanning a large range in total stellar mass and star formation properties. We identify ˜65 000 star-forming regions (i.e. FUV sources), measure each galaxy's luminosity function, and characterize the relationships between the luminosity function slope (α) and several global galaxy properties. A final sample of 82 galaxies with reliable luminosity functions are used to define these relationships and represent the largest sample of galaxies with the largest range of galaxy properties used to study the connection between luminosity function properties and galaxy environment. We find that α correlates with global star formation properties, where galaxies with higher star formation rates and star formation rate densities (ΣSFR) tend to have flatter luminosity function slopes. In addition, we find that neither stochastic sampling of the luminosity function in galaxies with low-number statistics nor the effects of blending due to distance can fully account for these trends. We hypothesize that the flatter slopes in high ΣSFR galaxies is due to higher gas densities and higher star formation efficiencies which result in proportionally greater numbers of bright star-forming regions. Finally, we create a composite luminosity function composed of star-forming regions from many galaxies and find a break in the luminosity function at brighter luminosities. However, we find that this break is an artefact of varying detection limits for galaxies at different distances.

  16. High-level expression of improved thermo-stable alkaline xylanase variant in Pichia Pastoris through codon optimization, multiple gene insertion and high-density fermentation.

    PubMed

    Lu, Yihong; Fang, Cheng; Wang, Qinhong; Zhou, Yuling; Zhang, Guimin; Ma, Yanhe

    2016-11-29

    In paper industry, xylanases are used to increase the pulp properties in bleaching process as its eco-friendly nature. The xylanases activity is hindered by high temperature and alkaline conditions with high enzyme production cost in the paper industry. Here, XynHB, an alkaline stable xylanase from Bacillus pumilus HBP8 was mutated at N188A to XynHBN188A. Expressed mutant in E. coli showed 1.5-fold higher xylanase activity than XynHB at 60 °C. The mutant expressed in Pichia pastoris was glycosylated, remained stable for 30 min at 60 °C. XynHBN188A optimized based on codon usage bias for P. pastoris (xynHBN188As) showed an increase of 39.5% enzyme activity. The strain Y16 forming the largest hydrolysis halo in the xylan plate was used in shake flask experiments produced an enzyme activity of 6,403 U/ml. The Y16 strain had 9 copies of the recombinant xynHBN188As gene in the genome revealed by qPCR. The enzymatic activity increased to 48,241 U/ml in a 5 L fermentor. Supplement of 15 U/g xylanase enhanced the brightness of paper products by 2% in bleaching experiment, and thereby improved the tensile strength and burst factor by 13% and 6.5%, respectively. XynHBN188As has a great potential in paper industries.

  17. High-level expression of improved thermo-stable alkaline xylanase variant in Pichia Pastoris through codon optimization, multiple gene insertion and high-density fermentation

    PubMed Central

    Lu, Yihong; Fang, Cheng; Wang, Qinhong; Zhou, Yuling; Zhang, Guimin; Ma, Yanhe

    2016-01-01

    In paper industry, xylanases are used to increase the pulp properties in bleaching process as its eco-friendly nature. The xylanases activity is hindered by high temperature and alkaline conditions with high enzyme production cost in the paper industry. Here, XynHB, an alkaline stable xylanase from Bacillus pumilus HBP8 was mutated at N188A to XynHBN188A. Expressed mutant in E. coli showed 1.5-fold higher xylanase activity than XynHB at 60 °C. The mutant expressed in Pichia pastoris was glycosylated, remained stable for 30 min at 60 °C. XynHBN188A optimized based on codon usage bias for P. pastoris (xynHBN188As) showed an increase of 39.5% enzyme activity. The strain Y16 forming the largest hydrolysis halo in the xylan plate was used in shake flask experiments produced an enzyme activity of 6,403 U/ml. The Y16 strain had 9 copies of the recombinant xynHBN188As gene in the genome revealed by qPCR. The enzymatic activity increased to 48,241 U/ml in a 5 L fermentor. Supplement of 15 U/g xylanase enhanced the brightness of paper products by 2% in bleaching experiment, and thereby improved the tensile strength and burst factor by 13% and 6.5%, respectively. XynHBN188As has a great potential in paper industries. PMID:27897254

  18. Luminosity variations in several parallel auroral arcs before auroral breakup

    NASA Astrophysics Data System (ADS)

    Safargaleev, V.; Lyatsky, W.; Tagirov, V.

    1997-08-01

    Variation of the luminosity in two parallel auroral arcs before auroral breakup has been studied by using digitised TV-data with high temporal and spatial resolution. The intervals when a new arc appears near already existing one were chosen for analysis. It is shown, for all cases, that the appearance of a new arc is accompanied by fading or disappearance of another arc. We have named these events out-of-phase events, OP. Another type of luminosity variation is characterised by almost simultaneous enhancement of intensity in the both arcs (in-phase event, IP). The characteristic time of IP events is 10-20 s, whereas OP events last about one minute. Sometimes out-of-phase events begin as IP events. The possible mechanisms for OP and IP events are discussed.

  19. Direct Oxygen Abundances for the Lowest Luminosity LVL Galaxies

    NASA Astrophysics Data System (ADS)

    Berg, Danielle; Skillman, E. D.; Marble, A. R.; van Zee, L.; Engelbracht, C. W.

    2012-01-01

    We present new MMT spectroscopic observations of HII regions in 42 of the lowest luminosity galaxies in the Spitzer Local Volume Legacy (LVL) survey. For 31 of the galaxies in our sample we were able to measure the [OIII] ? auroral line at a strength of 4σ or greater, and thus determine oxygen abundances using the direct method. Direct oxygen abundances were compared to B-band luminosity, 4.5 μm luminosity, and stellar mass to characterize the luminosity-metallicity (L-Z) and mass-metallicity (M-Z) relationships at low-luminosity. We examined a "Combined Select” sample composed of 38 objects, from the present sample and the literature, with direct oxygen abundances and reliable distance determinations (based on the tip of the red giant branch or Cepheid variables). The B-band and 4.5 μm L-Z relationships were found to be 12+log(O/H) = (6.19±0.07) + (-0.12±0.01)MB and 12+log(O/H) = (5.93±0.11) + (-0.11±0.01)M[4.5] with dispersions of σ = 0.17 and σ = 0.14 respectively. Since the slope of the L-Z relationship doesn't seem to vary from the optical to the near-IR, as has been observed in studies of more luminous galaxies, we propose that less extinction due to dust is created in the lowest luminosity galaxies. We subsequently derived a M-Z relationship of 12+log(O/H) = (5.49±0.23) + (0.31±0.03)log M*, with a dispersion of σ = 0.16. None of the relationships seem to hold an advantage with respect to dispersion, supporting the idea of minimized dust. Additionally, the trend of N/O abundance with respect to B-V color and oxygen abundance was examined. Similar to the conclusions of van Zee & Haynes (2006), we find a positive correlation between N/O ratio and B-V color: log(N/O) = 0.92 (B-V) - 1.83. Furthermore, there are no objects with high N/O ratio below 12+log(O/H)=7.9.

  20. The pulse luminosity function of Swift gamma-ray bursts

    NASA Astrophysics Data System (ADS)

    Amaral-Rogers, A.; Willingale, R.; O'Brien, P. T.

    2017-01-01

    The complete Swift Burst Alert Telescope and X-Ray Telescope light curves of 118 gamma-ray bursts (GRBs) with known redshifts were fitted using the physical model of GRB pulses by Willingale et al. to produce a total of 607 pulses. We compute the pulse luminosity function utilizing three GRB formation rate models: a progenitor that traces the cosmic star formation rate density (CSFRD) with either a single population of GRBs, coupled to various evolutionary parameters, or a bimodal population of high- and low-luminosity GRBs; and a direct fit to the GRB formation rate excluding any a priori assumptions. We find that a single population of GRB pulses with an evolving luminosity function is preferred over all other univariate evolving GRB models, or bimodal luminosity functions in reproducing the observed GRB pulse L-z distribution and that the magnitude of the evolution in brightness is consistent with studies that utilize only the brightest GRB pulses. We determine that the appearance of a GRB formation rate density evolution component is an artefact of poor parametrization of the CSFRD at high redshifts rather than indicating evolution in the formation rate of early epoch GRBs. We conclude that the single brightest region of a GRB light curve holds no special property; by incorporating pulse data from the totality of GRB emission we boost the GRB population statistics by a factor of 5, rule out some models utilized to explain deficiencies in GRB formation rate modelling, and constrain more tightly some of the observed parameters of GRB behaviour.