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Sample records for high-dose three-dimensional radiation

  1. Global Gene Expression Responses to Low- or High-Dose Radiation in a Human Three-Dimensional Tissue Model

    PubMed Central

    Mezentsev, Alexandre; Amundson, Sally A.

    2011-01-01

    Accumulating data suggest that the biological responses to high and low doses of radiation are qualitatively different, necessitating the direct study of low-dose responses to better understand potential risks. Most such studies have used two-dimensional culture systems, which may not fully represent responses in three-dimensional tissues. To gain insight into low-dose responses in tissue, we have profiled global gene expression in EPI-200, a three-dimensional tissue model that imitates the structure and function of human epidermis, at 4, 16 and 24 h after exposure to high (2.5 Gy) and low (0.1 Gy) doses of low-LET protons. The most significant gene ontology groups among genes altered in expression were consistent with effects observed at the tissue level, where the low dose was associated with recovery and tissue repair, while the high dose resulted in loss of structural integrity and terminal differentiation. Network analysis of the significantly responding genes suggested that TP53 dominated the response to 2.5 Gy, while HNF4A, a novel transcription factor not previously associated with radiation response, was most prominent in the low-dose response. HNF4A protein levels and phosphorylation were found to increase in tissues and cells after low- but not high-dose irradiation. PMID:21486161

  2. Cone Beam CT-Based Three-Dimensional Planning in High-Dose-Rate Brachytherapy for Cervical Cancer

    SciTech Connect

    Al-Halabi, Hani; Portelance, Lorraine; Duclos, Marie; Reniers, Brigitte; Bahoric, Boris; Souhami, Luis

    2010-07-15

    Purpose: To evaluate dose-volume histograms (DVHs) of bladder and rectum from the use of cone beam CT (CBCT)-based three-dimensional (3D) treatment planning in intracavitary high-dose-rate brachytherapy (HDRB) for cervical cancer patients and to compare these parameters with International Commission on Radiation Units and Measurements (ICRU) of rectal and bladder reference point dose measurements. Methods and Materials: Thirteen patients with cervical cancer underwent HDRB insertions. CT-compatible tandem and ovoid applicators were used to obtain intraoperative CBCT images. The use of a rectal tube and injection of bladder contrast before scanning facilitated contouring the rectum and bladder. All patients underwent intraoperative orthogonal x-ray filming, and treatments were prescribed using standard two-dimensional planning and dosimetry. DVHs for the bladder and rectum were constructed for each treatment. The minimum dose in the most irradiated 2.0-cm{sup 3} volume of bladder (B{sub D2V}) and rectum (R{sub D2V}) were determined from DVHs and compared to ICRU reference point estimates of bladder (B{sub ICRU}) and rectum (R{sub ICRU}) doses. Results: Twenty-six CBCT-based plans were evaluated. The median B{sub ICRU} dose (347 cGy; range, 164-601 cGy) was significantly lower (p < 0.001) than the median B{sub D2V} (594 cGy; range, 260-969 cGy). The median R{sub ICRU} dose (405 cGy; range, 189-700 cGy) was also significantly lower (p = 0.037) than the median R{sub D2V} (488 cGy; range, 227-786 cGy). Conclusions: CBCT-based 3D planning can be used in HDRB for cervical cancer and is a convenient alternative to CT-based planning, with the advantage of minimizing applicator motion. Correlation with late effects will further define the role of CBCT-based 3D dosimetry in HDRB planning.

  3. Radiation hardness of three-dimensional polycrystalline diamond detectors

    SciTech Connect

    Lagomarsino, Stefano Sciortino, Silvio; Bellini, Marco; Corsi, Chiara; Cindro, Vladimir; Kanxheri, Keida; Servoli, Leonello; Morozzi, Arianna; Passeri, Daniele; Schmidt, Christian J.

    2015-05-11

    The three-dimensional concept in particle detection is based on the fabrication of columnar electrodes perpendicular to the surface of a solid state radiation sensor. It permits to improve the radiation resistance characteristics of a material by lowering the necessary bias voltage and shortening the charge carrier path inside the material. If applied to a long-recognized exceptionally radiation-hard material like diamond, this concept promises to pave the way to the realization of detectors of unprecedented performances. We fabricated conventional and three-dimensional polycrystalline diamond detectors, and tested them before and after neutron damage up to 1.2 ×10{sup 16 }cm{sup −2}, 1 MeV-equivalent neutron fluence. We found that the signal collected by the three-dimensional detectors is up to three times higher than that of the conventional planar ones, at the highest neutron damage ever experimented.

  4. Prospective Clinical Trial of Bladder Filling and Three-Dimensional Dosimetry in High-Dose-Rate Vaginal Cuff Brachytherapy

    SciTech Connect

    Stewart, Alexandra J.; Cormack, Robert A.; Lee, Hang; Xiong Li; Hansen, Jorgen L.; O'Farrell, Desmond A.; Viswanathan, Akila N.

    2008-11-01

    Purpose: To investigate the effect of bladder filling on dosimetry and to determine the best bladder dosimetric parameter for vaginal cuff brachytherapy. Methods and Materials: In this prospective clinical trial, a total of 20 women underwent vaginal cylinder high-dose-rate brachytherapy. The bladder was full for Fraction 2 and empty for Fraction 3. Dose-volume histogram and dose-surface histogram values were generated for the bladder, rectum, and urethra. The midline maximal bladder point (MBP) and the midline maximal rectal point were recorded. Paired t tests, Pearson correlations, and regression analyses were performed. Results: The volume and surface area of the irradiated bladder were significantly smaller when the bladder was empty than when full. Of the several dose-volume histogram and dose-surface histogram parameters evaluated, the bladder maximal dose received by 2 cm{sup 3} of tissue, volume of bladder receiving {>=}50% of the dose, volume of bladder receiving {>=}70% of the dose, and surface area of bladder receiving {>=}50% of the dose significantly predicted for the difference between the empty vs. full filling state. The volume of bladder receiving {>=}70% of the dose and the maximal dose received by 2 cm{sup 3} of tissue correlated significantly with the MBP. Bladder filling did not alter the volume or surface area of the rectum irradiated. However, an empty bladder did result in the nearest point of bowel being significantly closer to the vaginal cylinder than when the bladder was full. Conclusions: Patients undergoing vaginal cuff brachytherapy treated with an empty bladder have a lower bladder dose than those treated with a full bladder. The MBP correlated well with the volumetric assessments of bladder dose and provided a noninvasive method for reporting the MBP dose using three-dimensional imaging. The MBP can therefore be used as a surrogate for complex dosimetry in the clinic.

  5. Three-dimensional radiation transfer modeling in a dicotyledon leaf

    NASA Astrophysics Data System (ADS)

    Govaerts, Yves M.; Jacquemoud, Stéphane; Verstraete, Michel M.; Ustin, Susan L.

    1996-11-01

    The propagation of light in a typical dicotyledon leaf is investigated with a new Monte Carlo ray-tracing model. The three-dimensional internal cellular structure of the various leaf tissues, including the epidermis, the palisade parenchyma, and the spongy mesophyll, is explicitly described. Cells of different tissues are assigned appropriate morphologies and contain realistic amounts of water and chlorophyll. Each cell constituent is characterized by an index of refraction and an absorption coefficient. The objective of this study is to investigate how the internal three-dimensional structure of the tissues and the optical properties of cell constituents control the reflectance and transmittance of the leaf. Model results compare favorably with laboratory observations. The influence of the roughness of the epidermis on the reflection and absorption of light is investigated, and simulation results confirm that convex cells in the epidermis focus light on the palisade parenchyma and increase the absorption of radiation.

  6. Modified thermal radiation in three-dimensional photonic crystals

    NASA Astrophysics Data System (ADS)

    Li, Zhi-Yuan

    2002-12-01

    Thermal radiation from an empty blackbody cavity follows the conventional Wien’s displacement law. At a temperature T=2500 K, the maximum monochromatic radiation intensity lies at a wavelength of 1.16 μm, and radiation into the visible band occupies only 3% of the total radiation energy. In this paper, we show that when the cavity is filled with a three-dimensional photonic crystal, a strong thermal radiation band can appear in the visible regime, significantly improving the luminescence efficiency. This is attributed to the redistribution of photon density of states (DOS) in different frequency ranges in the photonic crystal leading to orders-of-magnitude enhancement of DOS in the visible wavelength over that in the infrared wavelengths.

  7. TWILIGHT: A Cellular Framework for Three-Dimensional Radiative Transfer

    NASA Astrophysics Data System (ADS)

    Khatami, David; Madore, Barry

    2015-01-01

    We describe a new framework for solving three-dimensional radiative transfer of arbitrary geometries, including a full characterisation of the wavelength-dependent anisotropic scattering, absorption, and thermal reemission of light by dust. By adopting a cellular approach to discretising the light and dust, the problem can be efficiently solved through a fully deterministic iterative process. As a proof of concept we present TWILIGHT, our implementation of the cellular approach, in order to demonstrate and benchmark the new method. TWILIGHT simultaneously renders over one hundred unique images of a given environment with no additional slowdown, enabling a close study of inclination effects of three-dimensional dust geometries. In addition to qualitative rendering tests, TWILIGHT is successfully tested against two Monte-Carlo radiative transfer benchmarks, producing similar brightness profiles at varying inclinations. With the proof-of-concept established, we describe the improvements and current developments underway using the cellular framework, including a technique to resolve the subgrid physics of dust radiative transfer from micron-scale grain models to kiloparsec-sized dust environments.

  8. THREE-DIMENSIONAL RADIATION TRANSFER IN YOUNG STELLAR OBJECTS

    SciTech Connect

    Whitney, B. A.; Honor, J.; Robitaille, T. P.; Bjorkman, J. E.; Dong, R.; Wolff, M. J.; Wood, K.

    2013-08-15

    We have updated our publicly available dust radiative transfer code (HOCHUNK3D) to include new emission processes and various three-dimensional (3D) geometries appropriate for forming stars. The 3D geometries include warps and spirals in disks, accretion hotspots on the central star, fractal clumping density enhancements, and misaligned inner disks. Additional axisymmetric (2D) features include gaps in disks and envelopes, ''puffed-up inner rims'' in disks, multiple bipolar cavity walls, and iteration of disk vertical structure assuming hydrostatic equilibrium (HSEQ). We include the option for simple power-law envelope geometry, which, combined with fractal clumping and bipolar cavities, can be used to model evolved stars as well as protostars. We include non-thermal emission from polycyclic aromatic hydrocarbons (PAHs) and very small grains, and external illumination from the interstellar radiation field. The grid structure was modified to allow multiple dust species in each cell; based on this, a simple prescription is implemented to model dust stratification. We describe these features in detail, and show example calculations of each. Some of the more interesting results include the following: (1) outflow cavities may be more clumpy than infalling envelopes. (2) PAH emission in high-mass stars may be a better indicator of evolutionary stage than the broadband spectral energy distribution slope; and related to this, (3) externally illuminated clumps and high-mass stars in optically thin clouds can masquerade as young stellar objects. (4) Our HSEQ models suggest that dust settling is likely ubiquitous in T Tauri disks, in agreement with previous observations.

  9. A practical three-dimensional dosimetry system for radiation therapy.

    PubMed

    Guo, Pengyi; Adamovics, John; Oldham, Mark

    2006-10-01

    There is a pressing need for a practical three-dimensional (3D) dosimetry system, convenient for clinical use, and with the accuracy and resolution to enable comprehensive verification of the complex dose distributions typical of modern radiation therapy. Here we introduce a dosimetry system that can achieve this challenge, consisting of a radiochromic dosimeter (PRESAGE) and a commercial optical computed tomography (CT) scanning system (OCTOPUS). PRESAGE is a transparent material with compelling properties for dosimetry, including insensitivity of the dose response to atmospheric exposure, a solid texture negating the need for an external container (reducing edge effects), and amenability to accurate optical CT scanning due to radiochromic optical contrast as opposed to light-scattering contrast. An evaluation of the performance and viability of the PRESAGE/OCTOPUS, combination for routine clinical 3D dosimetry is presented. The performance of the two components (scanner and dosimeter) was investigated separately prior to full system test. The optical CT scanner has a spatial resolution of < or = 1 mm, geometric accuracy within 1 mm, and high reconstruction linearity (with a R2 value of 0.9979 and a standard error of estimation of approximately 1%) relative to independent measurement. The overall performance of the PRESAGE/OCTOPUS system was evaluated with respect to a simple known 3D dose distribution, by comparison with GAFCHROMIC EBT film and the calculated dose from a commissioned planning system. The "measured" dose distribution in a cylindrical PRESAGE dosimeter (16 cm diameter and 11 cm height) was determined by optical-CT, using a filtered backprojection reconstruction algorithm. A three-way Gamma map comparison (4% dose difference and 4 mm distance to agreement), between the PRESAGE, EBT and calculated dose distributions, showed full agreement in measurable region of PRESAGE dosimeter (approximately 90% of radius). The EBT and PRESAGE distributions agreed

  10. A practical three-dimensional dosimetry system for radiation therapy.

    PubMed

    Guo, Pengyi; Adamovics, John; Oldham, Mark

    2006-10-01

    There is a pressing need for a practical three-dimensional (3D) dosimetry system, convenient for clinical use, and with the accuracy and resolution to enable comprehensive verification of the complex dose distributions typical of modern radiation therapy. Here we introduce a dosimetry system that can achieve this challenge, consisting of a radiochromic dosimeter (PRESAGE) and a commercial optical computed tomography (CT) scanning system (OCTOPUS). PRESAGE is a transparent material with compelling properties for dosimetry, including insensitivity of the dose response to atmospheric exposure, a solid texture negating the need for an external container (reducing edge effects), and amenability to accurate optical CT scanning due to radiochromic optical contrast as opposed to light-scattering contrast. An evaluation of the performance and viability of the PRESAGE/OCTOPUS, combination for routine clinical 3D dosimetry is presented. The performance of the two components (scanner and dosimeter) was investigated separately prior to full system test. The optical CT scanner has a spatial resolution of < or = 1 mm, geometric accuracy within 1 mm, and high reconstruction linearity (with a R2 value of 0.9979 and a standard error of estimation of approximately 1%) relative to independent measurement. The overall performance of the PRESAGE/OCTOPUS system was evaluated with respect to a simple known 3D dose distribution, by comparison with GAFCHROMIC EBT film and the calculated dose from a commissioned planning system. The "measured" dose distribution in a cylindrical PRESAGE dosimeter (16 cm diameter and 11 cm height) was determined by optical-CT, using a filtered backprojection reconstruction algorithm. A three-way Gamma map comparison (4% dose difference and 4 mm distance to agreement), between the PRESAGE, EBT and calculated dose distributions, showed full agreement in measurable region of PRESAGE dosimeter (approximately 90% of radius). The EBT and PRESAGE distributions agreed

  11. A practical three-dimensional dosimetry system for radiation therapy

    SciTech Connect

    Guo Pengyi; Adamovics, John; Oldham, Mark

    2006-10-15

    There is a pressing need for a practical three-dimensional (3D) dosimetry system, convenient for clinical use, and with the accuracy and resolution to enable comprehensive verification of the complex dose distributions typical of modern radiation therapy. Here we introduce a dosimetry system that can achieve this challenge, consisting of a radiochromic dosimeter (PRESAGE trade mark sign ) and a commercial optical computed tomography (CT) scanning system (OCTOPUS trade mark sign ). PRESAGE trade mark sign is a transparent material with compelling properties for dosimetry, including insensitivity of the dose response to atmospheric exposure, a solid texture negating the need for an external container (reducing edge effects), and amenability to accurate optical CT scanning due to radiochromic optical contrast as opposed to light-scattering contrast. An evaluation of the performance and viability of the PRESAGE trade mark sign /OCTOPUS, combination for routine clinical 3D dosimetry is presented. The performance of the two components (scanner and dosimeter) was investigated separately prior to full system test. The optical CT scanner has a spatial resolution of {<=}1 mm, geometric accuracy within 1 mm, and high reconstruction linearity (with a R{sup 2} value of 0.9979 and a standard error of estimation of {approx}1%) relative to independent measurement. The overall performance of the PRESAGE trade mark sign /OCTOPUS system was evaluated with respect to a simple known 3D dose distribution, by comparison with GAFCHROMIC[reg] EBT film and the calculated dose from a commissioned planning system. The 'measured' dose distribution in a cylindrical PRESAGE trade mark sign dosimeter (16 cm diameter and 11 cm height) was determined by optical-CT, using a filtered backprojection reconstruction algorithm. A three-way Gamma map comparison (4% dose difference and 4 mm distance to agreement), between the PRESAGE trade mark sign , EBT and calculated dose distributions, showed full

  12. The Frank Ellis memorial lecture: the use of three-dimensional imaging in gynaecological radiation therapy.

    PubMed

    Viswanathan, A N

    2008-02-01

    The use of three-dimensional image guidance in radiation therapy has increased dramatically over the past decade. In gynaecological malignancies, three-dimensional image guidance assists with both external beam and brachytherapy treatment planning, increasing the accuracy of dose delivery. During his lifetime, Frank Ellis made significant contributions to gynaecological brachytherapy. This lecture will focus on novel advances in three-dimensional image-guided radiation therapy for cervical cancer, with the ultimate goal of improving outcomes for our patients.

  13. Three-dimensional, position-sensitive radiation detection

    DOEpatents

    He, Zhong; Zhang, Feng

    2010-04-06

    Disclosed herein is a method of determining a characteristic of radiation detected by a radiation detector via a multiple-pixel event having a plurality of radiation interactions. The method includes determining a cathode-to-anode signal ratio for a selected interaction of the plurality of radiation interactions based on electron drift time data for the selected interaction, and determining the radiation characteristic for the multiple-pixel event based on both the cathode-to-anode signal ratio and the electron drift time data. In some embodiments, the method further includes determining a correction factor for the radiation characteristic based on an interaction depth of the plurality of radiation interactions, a lateral distance between the selected interaction and a further interaction of the plurality of radiation interactions, and the lateral positioning of the plurality of radiation interactions.

  14. Preliminary results of a three-dimensional radiative transfer model

    SciTech Connect

    O`Hirok, W.

    1995-09-01

    Clouds act as the primary modulator of the Earth`s radiation at the top of the atmosphere, within the atmospheric column, and at the Earth`s surface. They interact with both shortwave and longwave radiation, but it is primarily in the case of shortwave where most of the uncertainty lies because of the difficulties in treating scattered solar radiation. To understand cloud-radiative interactions, radiative transfer models portray clouds as plane-parallel homogeneous entities to ease the computational physics. Unfortunately, clouds are far from being homogeneous, and large differences between measurement and theory point to a stronger need to understand and model cloud macrophysical properties. In an attempt to better comprehend the role of cloud morphology on the 3-dimensional radiation field, a Monte Carlo model has been developed. This model can simulate broadband shortwave radiation fluxes while incorporating all of the major atmospheric constituents. The model is used to investigate the cloud absorption anomaly where cloud absorption measurements exceed theoretical estimates and to examine the efficacy of ERBE measurements and cloud field experiments. 3 figs.

  15. Understanding Accretion Disks through Three Dimensional Radiation MHD Simulations

    NASA Astrophysics Data System (ADS)

    Jiang, Yan-Fei

    I study the structures and thermal properties of black hole accretion disks in the radiation pressure dominated regime. Angular momentum transfer in the disk is provided by the turbulence generated by the magneto-rotational instability (MRI), which is calculated self-consistently with a recently developed 3D radiation magneto-hydrodynamics (MHD) code based on Athena. This code, developed by my collaborators and myself, couples both the radiation momentum and energy source terms with the ideal MHD equations by modifying the standard Godunov method to handle the stiff radiation source terms. We solve the two momentum equations of the radiation transfer equations with a variable Eddington tensor (VET), which is calculated with a time independent short characteristic module. This code is well tested and accurate in both optically thin and optically thick regimes. It is also accurate for both radiation pressure and gas pressure dominated flows. With this code, I find that when photon viscosity becomes significant, the ratio between Maxwell stress and Reynolds stress from the MRI turbulence can increase significantly with radiation pressure. The thermal instability of the radiation pressure dominated disk is then studied with vertically stratified shearing box simulations. Unlike the previous results claiming that the radiation pressure dominated disk with MRI turbulence can reach a steady state without showing any unstable behavior, I find that the radiation pressure dominated disks always either collapse or expand until we have to stop the simulations. During the thermal runaway, the heating and cooling rates from the simulations are consistent with the general criterion of thermal instability. However, details of the thermal runaway are different from the predictions of the standard alpha disk model, as many assumptions in that model are not satisfied in the simulations. We also identify the key reasons why previous simulations do not find the instability. The thermal

  16. Three-dimensional simulations of harmonic radiation and harmonic lasing

    NASA Astrophysics Data System (ADS)

    Schmitt, Mark J.; McVey, Brian D.

    Characteristics of the harmonic emission from free electron lasers (FELs) are examined in the spontaneous, coherent-spontaneous and stimulated emission regimes. The radiation at both odd and even harmonic frequencies is treated for electron beams with finite emittance and energy spread. In the spontaneous emission regime, the transverse radiation patterns including the transverse frequency dependences, are given. How this expression is modified to include energy spread and emittance is described. In the coherent-spontaneous emission and stimulated emission regimes, the interaction of the radiation fields with the electrons must be treated self consistently. Here, a single frequency distributed transverse source function for each electron is used in the harmonic version of the 3-D code FELEX to model the harmonic radiation. The code has recently been modified to simultaneously model the fundamental and harmonic interactions for multiple-pass oscillator simulations. These modifications facilitate the examination of FELs under various operating conditions. When the FEL is lasing at the fundamental, the evolution of the harmonic fields can be examined. This evolution is unique in the sense that the electron beam radiates at the harmonic frequencies in the presence of the harmonic radiation circulating in the cavity. As a result, enhancements of the harmonic emission can be observed. Finally, harmonic lasing can occur in cases where there is sufficient gain to overcome cavity losses and lasing at the fundamental can be suppressed. The characteristics and efficiency of these interactions are explored.

  17. Three-dimensional simulations of harmonic radiation and harmonic lasing

    NASA Astrophysics Data System (ADS)

    Schmitt, Mark J.; McVey, Brian D.

    1991-07-01

    Characteristics of the harmonic emission from free electron lasers (FELs) are examined in the spontaneous, coherent-spontaneous and stimulated emission regimes. The radiation at both odd and even harmonic frequencies is treated for electron beams with finite emittance and energy spread. In the spontaneous emission regime, the transverse radiation patterns including the transverse frequency dependences, are given. How this expression is modified to include energy spread and emittance is described. In the coherent-spontaneous emission and stimulated emission (lasing) regimes, the interaction of the radiation fields with the electrons must be treated self-consistently. Here, a single-frequency distributed transverse source function for each electron is used in the harmonic version (HELEX) of the 3D code FELEX to model the harmonic radiation. This code has recently been modified to simultaneously model the fundamental and harmonic interactions for multiple-pass oscillator simulations. These modifications facilitate the examination of FELs under various operating conditions. When the FEL is lasing at the fundamental, the evolution of the harmonic fields can be examined. This evolution is unique in the sense that the electron beam (which is bunched by the fundamental optical field) radiates at the harmonic frequencies in the presence of the harmonic radiation circulating in the cavity. As a result, enhancements of the harmonic emission can be observed. Finally, harmonic lasing can occur in cases where there is sufficient gain to overcome cavity losses and lasing at the fundamental can be suppressed. The characteristics and efficiency of these interactions are explored.

  18. Three Dimensional Radiative Transfer In Tropical Deep Convective Clouds.

    NASA Astrophysics Data System (ADS)

    di Giuseppe, F.

    In this study the focus is on the interaction between short-wave radiation with a field of tropical deep convective events generated using a 3D cloud resolving model (CRM) to assess the significance of 3D radiative transport (3DRT). It is not currently un- derstood what magnitude of error is involved when a two stream approximation is used to describe the radiative transfer through such a cloud field. It seems likely that deep convective clouds could be the most complex to represent, and that the error in neglecting horizontal transport could be relevant in these cases. The field here con- sidered has an extention of roughly 90x90 km, approximately equivalent to the grid box dimension of many global models. The 3DRT results are compared both with the calculations obtained by an Independent Pixel Approximation (IPA) approch and by the Plane Parallel radiative scheme (PP) implemented in ECMWF's Forecast model. The differences between the three calculations are used to assess both problems in current GCM's representation of radiative heating and inaccuracies in the dynamical response of CRM simulations due to the Independent Column Approximation (ICA). The understanding of the mechanisms involved in the main 3DRT/1D differences is the starting point for the future attempt to develop a parameterization procedure.

  19. Three-dimensional architecture for solid state radiation detectors

    DOEpatents

    Parker, S.

    1999-03-30

    A radiation-damage resistant radiation detector is formed on a substrate formed of a material doped with a first conductivity type dopant. The detector includes at least one first electrode formed of first conductivity type dopant, and at least one second electrode that is spaced-apart from the first electrode and formed of a second conductivity type dopant. Each first and second electrode penetrates into the substrate from a substrate surface, and one or more electrodes may penetrate entirely through the substrate, that is traversing from one surface to the other surface. Particulate and/or electromagnetic radiation penetrating at least a surface of the substrate releases electrons and holes in substrate regions. Because the electrodes may be formed entirely through the substrate thickness, the released charges will be a relatively small distance from at least a portion of such an electrode, e.g., a distance less than the substrate thickness. The electrons and/or holes traverse the small distance and are collected by said electrodes, thus promoting rapid detection of the radiation. By providing one or more electrodes with a dopant profile radially graded in a direction parallel to a substrate surface, an electric field results that promotes rapid collection of released electrons and said holes. Monolithic combinations of such detectors may be fabricated including CMOS electronics to process radiation signals. 45 figs.

  20. Three-dimensional architecture for solid state radiation detectors

    DOEpatents

    Parker, Sherwood

    1999-01-01

    A radiation-damage resistant radiation detector is formed on a substrate formed of a material doped with a first conductivity type dopant. The detector includes at least one first electrode formed of first conductivity type dopant, and at least one second electrode that is spaced-apart from the first electrode and formed of a second conductivity type dopant. Each first and second electrode penetrates into the substrate from a substrate surface, and one or more electrodes may penetrate entirely through the substrate, that is traversing from one surface to the other surface. Particulate and/or electromagnetic radiation penetrating at least a surface of the substrate releases electrons and holes in substrate regions. Because the electrodes may be formed entirely through the substrate thickness, the released charges will be a relatively small distance from at least a portion of such an electrode, e.g., a distance less than the substrate thickness. The electrons and/or holes traverse the small distance and are collected by said electrodes, thus promoting rapid detection of the radiation. By providing one or more electrodes with a dopant profile radially graded in a direction parallel to a substrate surface, an electric field results that promotes rapid collection of released electrons and said holes. Monolithic combinations of such detectors may be fabricated including CMOS electronics to process radiation signals.

  1. Formation of globular clusters induced by external ultraviolet radiation II: Three-dimensional radiation hydrodynamics simulations

    NASA Astrophysics Data System (ADS)

    Abe, Makito; Umemura, Masayuki; Hasegawa, Kenji

    2016-08-01

    We explore the possibility of the formation of globular clusters under ultraviolet (UV) background radiation. One-dimensional spherical symmetric radiation hydrodynamics (RHD) simulations by Hasegawa et al. have demonstrated that the collapse of low-mass (106-7 M⊙) gas clouds exposed to intense UV radiation can lead to the formation of compact star clusters like globular clusters (GCs) if gas clouds contract with supersonic infall velocities. However, three-dimensional effects, such as the anisotropy of background radiation and the inhomogeneity in gas clouds, have not been studied so far. In this paper, we perform three-dimensional RHD simulations in a semi-cosmological context, and reconsider the formation of compact star clusters in strong UV radiation fields. As a result, we find that although anisotropic radiation fields bring an elongated shadow of neutral gas, almost spherical compact star clusters can be procreated from a "supersonic infall" cloud, since photo-dissociating radiation suppresses the formation of hydrogen molecules in the shadowed regions and the regions are compressed by UV heated ambient gas. The properties of resultant star clusters match those of GCs. On the other hand, in weak UV radiation fields, dark matter-dominated star clusters with low stellar density form due to the self-shielding effect as well as the positive feedback by ionizing photons. Thus, we conclude that the "supersonic infall" under a strong UV background is a potential mechanism to form GCs.

  2. Three Dimensional Atmospheric Radiative Transfer-Applications and Methods Comparison

    NASA Technical Reports Server (NTRS)

    Cahalan, Robert F.; Einaudi, Franco (Technical Monitor)

    2001-01-01

    We review applications of 3D radiative transfer in the atmosphere, emphasizing the wide spectrum of scales important to remote sensing and modeling of cloud fields, and the characteristic scales introduced into observed radiances and fluxes by the distribution of photon pathlengths at conservative and absorbing wavelengths. We define the "plane-parallel bias", which is a measure of the importance of 3D cloud structure in large-scale models, and the "independent pixel errors" that quantify the significance of 3D effects in remote sensing, and emphasize their relative magnitude and scale dependence. A variety of approaches in current use in 3D radiative transfer, and issues of speed, accuracy, and flexibility are summarized. We also describe a recently initiated "International Intercomparison of 3-Dimensional Radiation Codes", or I3RC. I3RC is a 3-phase effort that has as its goals to: (1) understand the errors and limits of 3D methods; (2) provide "baseline" cases for future 3D code development; (3) promote sharing of 3D tools; (4) derive guidelines for 3D tool selection; and (5) improve atmospheric science education in 3D radiative transfer. Selected results from Phases 1 and 2 of I3RC are discussed. These are taken from five cloud fields: a 1D field of bar clouds, a 2D radar-derived field, a 3D Landsat-derived field, a stratiform cloud from the model of C. Moeng, and a convective cloud from the model of B. Stevens. Computations have been carried out for three monochromatic wavelengths (one conservative, one absorptive, and one thermal) and two solar zenith angles (0, 60 degrees).

  3. Three-dimensional radiative transfer on a massively parallel computer

    NASA Technical Reports Server (NTRS)

    Vath, H. M.

    1994-01-01

    We perform 3D radiative transfer calculations in non-local thermodynamic equilibrium (NLTE) in the simple two-level atom approximation on the Mas-Par MP-1, which contains 8192 processors and is a single instruction multiple data (SIMD) machine, an example of the new generation of massively parallel computers. On such a machine, all processors execute the same command at a given time, but on different data. To make radiative transfer calculations efficient, we must re-consider the numerical methods and storage of data. To solve the transfer equation, we adopt the short characteristic method and examine different acceleration methods to obtain the source function. We use the ALI method and test local and non-local operators. Furthermore, we compare the Ng and the orthomin methods of acceleration. We also investigate the use of multi-grid methods to get fast solutions for the NLTE case. In order to test these numerical methods, we apply them to two problems with and without periodic boundary conditions.

  4. Three-dimensional modeling of radiative disks in binaries

    NASA Astrophysics Data System (ADS)

    Picogna, G.; Marzari, F.

    2013-08-01

    Context. Circumstellar disks in binaries are perturbed by the companion gravity causing significant alterations of the disk morphology. Spiral waves due to the companion tidal force also develop in the vertical direction and affect the disk temperature profile. These effects may significantly influence the process of planet formation. Aims: We perform 3D numerical simulations of disks in binaries with different initial dynamical configurations and physical parameters. Our goal is to investigate their evolution and their propensity to grow planets. Methods: We use an improved version of the SPH code VINE modified to better account for momentum and energy conservation via variable smoothing and softening length. The energy equation includes a flux-limited radiative transfer algorithm. The disk cooling is obtained with the use of "boundary particles" populating the outer surfaces of the disk and radiating to infinity. We model a system made of star/disk + star/disk where the secondary star (and relative disk) is less massive than the primary. Results: The numerical simulations performed for different values of binary separation and disk density show that trailing spiral shock waves develop when the stars approach their pericenter. Strong hydraulic jumps occur at the shock front, in particular for small separation binaries, creating breaking waves, and a consistent mass stream between the two disks. Both shock waves and mass transfer cause significant heating of the disk. At apocenter these perturbations are reduced and the disks are cooled down and less eccentric. Conclusions: The disk morphology is substantially affected by the companion perturbations, in particular in the vertical direction. The hydraulic jumps may slow down or even halt the dust coagulation process. The disk is significantly heated up by spiral waves and mass transfer, and the high gas temperature may prevent the ice condensation by moving the "snow line" outward. The disordered motion triggered by

  5. Three-dimensional visualization of shear wave propagation generated by dual acoustic radiation pressure

    NASA Astrophysics Data System (ADS)

    Mochizuki, Yuta; Taki, Hirofumi; Kanai, Hiroshi

    2016-07-01

    An elastic property of biological soft tissue is an important indicator of the tissue status. Therefore, quantitative and noninvasive methods for elasticity evaluation have been proposed. Our group previously proposed a method using acoustic radiation pressure irradiated from two directions for elastic property evaluation, in which by measuring the propagation velocity of the shear wave generated by the acoustic radiation pressure inside the object, the elastic properties of the object were successfully evaluated. In the present study, we visualized the propagation of the shear wave in a three-dimensional space by the synchronization of signals received at various probe positions. The proposed method succeeded in visualizing the shear wave propagation clearly in the three-dimensional space of 35 × 41 × 4 mm3. These results show the high potential of the proposed method to estimate the elastic properties of the object in the three-dimensional space.

  6. Multigroup Three-Dimensional Direct Integration Method Radiation Transport Analysis Code System.

    1987-09-18

    Version 00 TRISTAN solves the three-dimensional, fixed-source, Boltzmann transport equation for neutrons or gamma rays in rectangular geometry. The code can solve an adjoint problem as well as a usual transport problem. TRISTAN is a suitable tool to analyze radiation shielding problems such as streaming and deep penetration problems.

  7. Recent Developments in Three Dimensional Radiation Transport Using the Green's Function Technique

    NASA Technical Reports Server (NTRS)

    Rockell, Candice; Tweed, John; Blattnig, Steve R.; Mertens, Christopher J.

    2010-01-01

    In the future, astronauts will be sent into space for longer durations of time compared to previous missions. The increased risk of exposure to dangerous radiation, such as Galactic Cosmic Rays and Solar Particle Events, is of great concern. Consequently, steps must be taken to ensure astronaut safety by providing adequate shielding. In order to better determine and verify shielding requirements, an accurate and efficient radiation transport code based on a fully three dimensional radiation transport model using the Green's function technique is being developed

  8. Hawking radiation of spin-1 particles from a three-dimensional rotating hairy black hole

    SciTech Connect

    Sakalli, I.; Ovgun, A.

    2015-09-15

    We study the Hawking radiation of spin-1 particles (so-called vector particles) from a three-dimensional rotating black hole with scalar hair using a Hamilton–Jacobi ansatz. Using the Proca equation in the WKB approximation, we obtain the tunneling spectrum of vector particles. We recover the standard Hawking temperature corresponding to the emission of these particles from a rotating black hole with scalar hair.

  9. Hawking radiation of spin-1 particles from a three-dimensional rotating hairy black hole

    NASA Astrophysics Data System (ADS)

    Sakalli, I.; Ovgun, A.

    2015-09-01

    We study the Hawking radiation of spin-1 particles (so-called vector particles) from a three-dimensional rotating black hole with scalar hair using a Hamilton-Jacobi ansatz. Using the Proca equation in the WKB approximation, we obtain the tunneling spectrum of vector particles. We recover the standard Hawking temperature corresponding to the emission of these particles from a rotating black hole with scalar hair.

  10. Three-dimensional radiative transfer calculations on an SIMD machine applied to accretion disks

    NASA Technical Reports Server (NTRS)

    Vath, H.

    1994-01-01

    We have developed a tool to solve the radiative transfer equation for a three-dimensional astrophysical object on the SIMD computer MasPar MP-1. With this tool we can rapidly calculate the image of such an object as seen from an arbitrary direction and at an arbitrary wavelength. Such images and spectra can then be used to directly compare observations with the model. This tool can be applied to many different areas in astrophysics, e.g., HI disks of galaxies and polarized radiative transfer of accretion columns onto white dwarfs. Here we use this tool to calculate the image and spectrum of a simple model of an accretion disk.

  11. Three-dimensional surface grid generation for calculation of thermal radiation shape factors

    NASA Technical Reports Server (NTRS)

    Aly, Hany M.

    1992-01-01

    A technique is described to generate three dimensional surface grids suitable for calculating shape factors for thermal radiative heat transfer. The surface under consideration is approximated by finite triangular elements generated in a special manner. The grid is generated by dividing the surface into a two dimensional array of nodes. Each node is defined by its coordinates. Each set of four adjacent nodes is used to construct two triangular elements. Each triangular element is characterized by the vector representation of its vertices. Vector algebra is used to calculate all desired geometric properties of grid elements. The properties are used to determine the shape factor between the element and an area element in space. The grid generation can be graphically displayed using any software with three dimensional features. DISSPLA was used to view the grids.

  12. Modelling canopy scale solar induced chlorophyll fluorescence simulated by the three dimensional radiative transfer model

    NASA Astrophysics Data System (ADS)

    Kobayashi, H.; Nagai, S.; Inoue, T.; Yang, W.; Ichii, K.

    2014-12-01

    Recent studies show that the vegetation canopy scale sun-induced chlorophyll fluorescence (SIF) can be observed from satellite. To understand how the canopy scale bidirectional fluorescence observations are related to three-dimensional fluorescence distribution within a plant canopy, it is necessary to evaluate canopy scale fluorescence emission using a detailed plant canopy radiative transfer model. In this study, we developed a three-dimensional plant canopy radiative transfer model that can simulate the bidirectional chlorophyll fluorescence radiance and show several preliminary results of fluorescence distribution at the tree level. To simulate the three dimensional variations in chlorophyll fluorescence from trees, we measured tree structures using a terrestrial LiDAR instrument. The measurements were conducted in Yokohama, Japan (35°22'49" N 139°37'29" E). Three Japanese cherry trees (Cerasus Speciosa) were chosen for our study (Figure 1). Leaf-level sun-induced chlorophyll fluorescence (SIF) is also necessary as an input of radiative transfer model. To measure the leaf-level SIF, we used high spectral resolution spectroradiometer (HR 4000, Ocean Optics Inc. USA). The spectral resolution of this instrument is 0.05 nm (full width half maximum). The spectral range measured was 720 to 780 nm. From the spectral radiance measurements, we estimated SIF using the three band Fraunhofer Line Depth (3FLD) method. The effect of solar and view zenith angles, multiple scattering depends on many factors such as back ground reflectance, leaf reflectance transmittance and landscape structures. To understand how the SIF from both sparse and dense forest stands vary with sun and view angles and optical variables, it is necessary to conduct further sensitivity analysis. Radiative transfer simulation will help understand SIF emission at variety of forest canopy cases.

  13. On the Development of a Deterministic Three-Dimensional Radiation Transport Code

    NASA Technical Reports Server (NTRS)

    Rockell, Candice; Tweed, John

    2011-01-01

    Since astronauts on future deep space missions will be exposed to dangerous radiations, there is a need to accurately model the transport of radiation through shielding materials and to estimate the received radiation dose. In response to this need a three dimensional deterministic code for space radiation transport is now under development. The new code GRNTRN is based on a Green's function solution of the Boltzmann transport equation that is constructed in the form of a Neumann series. Analytical approximations will be obtained for the first three terms of the Neumann series and the remainder will be estimated by a non-perturbative technique . This work discusses progress made to date and exhibits some computations based on the first two Neumann series terms.

  14. MHD three-dimensional flow of nanofluid with velocity slip and nonlinear thermal radiation

    NASA Astrophysics Data System (ADS)

    Hayat, Tasawar; Imtiaz, Maria; Alsaedi, Ahmed; Kutbi, Marwan A.

    2015-12-01

    An analysis has been carried out for the three dimensional flow of viscous nanofluid in the presence of partial slip and thermal radiation effects. The flow is induced by a permeable stretching surface. Water is treated as a base fluid and alumina as a nanoparticle. Fluid is electrically conducting in the presence of applied magnetic field. Entire different concept of nonlinear thermal radiation is utilized in the heat transfer process. Different from the previous literature, the nonlinear system for temperature distribution is solved and analyzed. Appropriate transformations reduce the nonlinear partial differential system to ordinary differential system. Convergent series solutions are computed for the velocity and temperature. Effects of different parameters on the velocity, temperature, skin friction coefficient and Nusselt number are computed and examined. It is concluded that heat transfer rate increases when temperature and radiation parameters are increased.

  15. Radiation reaction on charged particles in three-dimensional motion in classical and quantum electrodynamics

    SciTech Connect

    Higuchi, Atsushi; Martin, Giles D. R.

    2006-01-15

    We extend our previous work [A. Higuchi and G. D. R. Martin, Found. Phys. 35, 1149 (2005)], which compared the predictions of quantum electrodynamics concerning radiation reaction with those of the Abraham-Lorentz-Dirac theory for a charged particle in linear motion. Specifically, we calculate the predictions for the change in position of a charged-scalar particle, moving in three-dimensional space, due to the effect of radiation reaction in the one-photon-emission process in quantum electrodynamics. The scalar particle is assumed to be accelerated for a finite period of time by a three-dimensional electromagnetic potential dependent only on one of the spacetime coordinates. We perform this calculation in the ({Dirac_h}/2{pi}){yields}0 limit and show that the change in position agrees with that obtained in classical electrodynamics with the Lorentz-Dirac force treated as a perturbation. We also show for a time-dependent but space-independent electromagnetic potential that the forward-scattering amplitude at order e{sup 2} does not contribute to the position change in the ({Dirac_h}/2{pi}){yields}0 limit after the mass renormalization is taken into account.

  16. The Coupling of Finite Element and Integral Equation Representations for Efficient Three-Dimensional Modeling of Electromagnetic Scattering and Radiation

    NASA Technical Reports Server (NTRS)

    Cwik, Tom; Zuffada, Cinzia; Jamnejad, Vahraz

    1996-01-01

    Finite element modeling has proven useful for accurtely simulating scattered or radiated fields from complex three-dimensional objects whose geometry varies on the scale of a fraction of a wavelength.

  17. Simulation of radiation effects on three-dimensional computer optical memories

    NASA Technical Reports Server (NTRS)

    Moscovitch, M.; Emfietzoglou, D.

    1997-01-01

    A model was developed to simulate the effects of heavy charged-particle (HCP) radiation on the information stored in three-dimensional computer optical memories. The model is based on (i) the HCP track radial dose distribution, (ii) the spatial and temporal distribution of temperature in the track, (iii) the matrix-specific radiation-induced changes that will affect the response, and (iv) the kinetics of transition of photochromic molecules from the colored to the colorless isomeric form (bit flip). It is shown that information stored in a volume of several nanometers radius around the particle's track axis may be lost. The magnitude of the effect is dependent on the particle's track structure.

  18. Three-dimensional numerical analysis of terahertz radiation emitted from intrinsic Josephson junctions with hot spots

    NASA Astrophysics Data System (ADS)

    Asai, Hidehiro; Tachiki, Masashi; Kadowaki, Kazuo

    2012-02-01

    In this study, we numerically investigate the terahertz radiation from mesa-structured intrinsic Josephson junctions (IJJs) using a three-dimensional calculation model. We assume an in-phase mode of the phase differences and calculate electromagnetic fields inside and outside of the IJJs simultaneously. We consider the appearance of a hot spot in the mesa where jc locally decreases and investigate the change of the radiation power with varying hot-spot positions. The radiation powers for three different hot-spot positions are calculated as functions of voltage. We observe strong radiation when the ac Josephson frequency satisfies the cavity resonance condition. Transverse-magnetic modes TMm,n whose indices m and n are even appear regardless of the positions of hot spots. Meanwhile, the TMm,n cavity modes whose m or n are odd appear only when the hot spots break the reflectional symmetry of the mesa structure. Moreover, we calculate the radiation patterns emitted by the IJJs at these cavity resonance conditions. The radiation patterns reflect the existence of two types of internal modes, that is, a uniform background mode and a cavity resonance mode.

  19. Three-dimensional Culture Conditions Lead to Decreased Radiation Induced Crytoxicity in Human Mammary Epithelial Cells

    SciTech Connect

    Sowa, Marianne B.; Chrisler, William B.; Zens, Kyra D.; Ashjian, Emily J.; Opresko, Lee K.

    2010-05-01

    For both targeted and non-targeted exposures, the cellular responses to ionizing radiation have predominantly been measured in two dimensional monolayer cultures. Although convenient for biochemical analysis, the true interactions in vivo depend upon complex interactions between cells themselves and the surrounding extra cellular matrix. This study directly compares the influence of culture conditions on radiation induced cytotoxicity following exposure to low-LET ionizing radiation. Using a three dimensional (3D) human mammary epithelial tissue model, we have found a protective effect of 3D cell culture on cell survival after irradiation. The initial state of the cells (i.e., 2D vs. 3D culture) at the time of irradiation does not alter survival, nor does the presence of extracellular matrix during and after exposure to dose, but long term culture in 3D which offers significant reduction in cytotoxicity at a given dose (e.g. ~4 fold increased survival at 5 Gy). The cell cycle delay induced following exposure to 2 and 5 Gy was almost identical between 2D and 3D culture conditions and cannot account for the observed differences in radiation responses. However the amount of apoptosis following radiation exposure is significantly decreased in 3D culture relative to the 2D monolayer after the same dose. A likely mechanism of the cytoprotective effect afforded by 3D culture conditions is the down regulation of radiation induced apoptosis in 3D structures

  20. A global three-dimensional radiation magneto-hydrodynamic simulation of super-eddington accretion disks

    SciTech Connect

    Jiang, Yan-Fei; Stone, James M.; Davis, Shane W.

    2014-12-01

    We study super-Eddington accretion flows onto black holes using a global three-dimensional radiation magneto-hydrodynamical simulation. We solve the time-dependent radiative transfer equation for the specific intensities to accurately calculate the angular distribution of the emitted radiation. Turbulence generated by the magneto-rotational instability provides self-consistent angular momentum transfer. The simulation reaches inflow equilibrium with an accretion rate ∼220 L {sub Edd}/c {sup 2} and forms a radiation-driven outflow along the rotation axis. The mechanical energy flux carried by the outflow is ∼20% of the radiative energy flux. The total mass flux lost in the outflow is about 29% of the net accretion rate. The radiative luminosity of this flow is ∼10 L {sub Edd}. This yields a radiative efficiency ∼4.5%, which is comparable to the value in a standard thin disk model. In our simulation, vertical advection of radiation caused by magnetic buoyancy transports energy faster than photon diffusion, allowing a significant fraction of the photons to escape from the surface of the disk before being advected into the black hole. We contrast our results with the lower radiative efficiencies inferred in most models, such as the slim disk model, which neglect vertical advection. Our inferred radiative efficiencies also exceed published results from previous global numerical simulations, which did not attribute a significant role to vertical advection. We briefly discuss the implications for the growth of supermassive black holes in the early universe and describe how these results provided a basis for explaining the spectrum and population statistics of ultraluminous X-ray sources.

  1. A Global Three-dimensional Radiation Magneto-hydrodynamic Simulation of Super-Eddington Accretion Disks

    NASA Astrophysics Data System (ADS)

    Jiang, Yan-Fei; Stone, James M.; Davis, Shane W.

    2014-12-01

    We study super-Eddington accretion flows onto black holes using a global three-dimensional radiation magneto-hydrodynamical simulation. We solve the time-dependent radiative transfer equation for the specific intensities to accurately calculate the angular distribution of the emitted radiation. Turbulence generated by the magneto-rotational instability provides self-consistent angular momentum transfer. The simulation reaches inflow equilibrium with an accretion rate ~220 L Edd/c 2 and forms a radiation-driven outflow along the rotation axis. The mechanical energy flux carried by the outflow is ~20% of the radiative energy flux. The total mass flux lost in the outflow is about 29% of the net accretion rate. The radiative luminosity of this flow is ~10 L Edd. This yields a radiative efficiency ~4.5%, which is comparable to the value in a standard thin disk model. In our simulation, vertical advection of radiation caused by magnetic buoyancy transports energy faster than photon diffusion, allowing a significant fraction of the photons to escape from the surface of the disk before being advected into the black hole. We contrast our results with the lower radiative efficiencies inferred in most models, such as the slim disk model, which neglect vertical advection. Our inferred radiative efficiencies also exceed published results from previous global numerical simulations, which did not attribute a significant role to vertical advection. We briefly discuss the implications for the growth of supermassive black holes in the early universe and describe how these results provided a basis for explaining the spectrum and population statistics of ultraluminous X-ray sources.

  2. Three-dimensional, global, radiative GRMHD simulations of a thermally unstable disc

    NASA Astrophysics Data System (ADS)

    Mishra, B.; Fragile, P. C.; Johnson, C. L.; Kluźniak, W.

    2016-09-01

    We present results of a set of three-dimensional, general relativistic radiation magnetohydrodynamics simulations of thin accretion discs around a non-rotating black hole to test their thermal stability. We consider two cases, one that is initially radiation-pressure dominated and expected to be thermally unstable and another that is initially gas-pressure dominated and expected to remain stable. Indeed, we find that cooling dominates over heating in the radiation-pressure-dominated model, causing the disc to collapse vertically on roughly the local cooling timescale. We also find that heating and cooling within the disc have a different dependence on the mid-plane pressure-a prerequisite of thermal instability. Comparison of our data with the relevant thin-disc thermal equilibrium curve suggests that our disc may be headed for the thermally stable, gas-pressure-dominated branch. However, because the disc collapses to the point that we are no longer able to resolve it, we had to terminate the simulation. On the other hand, the gas-pressure-dominated model, which was run for twice as long as the radiation-pressure-dominated one, remains stable, with heating and cooling roughly in balance. Finally, the radiation pressure dominated simulation shows some evidence of viscous instability. The strongest evidence is in plots of surface density, which show the disc breaking up into rings.

  3. Apparatus and method for high dose rate brachytherapy radiation treatment

    DOEpatents

    Macey, Daniel J.; Majewski, Stanislaw; Weisenberger, Andrew G.; Smith, Mark Frederick; Kross, Brian James

    2005-01-25

    A method and apparatus for the in vivo location and tracking of a radioactive seed source during and after brachytherapy treatment. The method comprises obtaining multiple views of the seed source in a living organism using: 1) a single PSPMT detector that is exposed through a multiplicity of pinholes thereby obtaining a plurality of images from a single angle; 2) a single PSPMT detector that may obtain an image through a single pinhole or a plurality of pinholes from a plurality of angles through movement of the detector; or 3) a plurality of PSPMT detectors that obtain a plurality of views from different angles simultaneously or virtually simultaneously. The plurality of images obtained from these various techniques, through angular displacement of the various acquired images, provide the information required to generate the three dimensional images needed to define the location of the radioactive seed source within the body of the living organism.

  4. Physics-based visualization of dense natural clouds. I. Three-dimensional discrete ordinates radiative transfer.

    PubMed

    Tofsted, D H; O'Brien, S G

    1998-11-20

    A technique is developed to model radiative transfer in three-dimensional natural clouds with a standard discrete ordinates finite-element method modified to evaluate cell-surface-averaged radiances. A log-least-squares-based scale transformation is used to improve the discrete phase-function model. We handle dense media by assuming constant diffuse radiances over input faces to cubic cells, allowing analytical forms for transmittance factors. Transmission equations are combined with diffuse volumetric single-scattering calculations to support evaluations of cell energy balance. Energy not accounted for volumetrically is treated with surface-based effects. Results produced show accurate flux computations at over 30 optical depths per modeled cell. Comparisons with nonuniform cloud Monte Carlo calculations show less than 1% rms error and correlations greater than 0.999 for cases in which cloud-density fluctuations are resolved.

  5. Scattering and radiation analysis of three-dimensional cavity arrays via a hybrid finite element method

    NASA Technical Reports Server (NTRS)

    Jin, Jian-Ming; Volakis, John L.

    1992-01-01

    A hybrid numerical technique is presented for a characterization of the scattering and radiation properties of three-dimensional cavity arrays recessed in a ground plane. The technique combines the finite element and boundary integral methods and invokes Floquet's representation to formulate a system of equations for the fields at the apertures and those inside the cavities. The system is solved via the conjugate gradient method in conjunction with the Fast Fourier Transform (FFT) thus achieving an O(N) storage requirement. By virtue of the finite element method, the proposed technique is applicable to periodic arrays comprised of cavities having arbitrary shape and filled with inhomogeneous dielectrics. Several numerical results are presented, along with new measured data, which demonstrate the validity, efficiency, and capability of the technique.

  6. Three-dimensional aspects of radiative transfer in remote sensing of precipitation: Application to the 1986 COHMEX storm

    NASA Technical Reports Server (NTRS)

    Haferman, J. L.; Krajewski, W. F.; Smith, T. F.

    1994-01-01

    Several multifrequency techniques for passive microwave estimation of precipitation based on the absorption and scattering properties of hydrometers have been proposed in the literature. In the present study, plane-parallel limitations are overcome by using a model based on the discrete-ordinates method to solve the radiative transfer equation in three-dimensional rectangular domains. This effectively accounts for the complexity and variety of radiation problems encountered in the atmosphere. This investigation presents result for plane-parallel and three-dimensional radiative transfer for a precipitating system, discusses differences between these results, and suggests possible explanations for these differences. Microphysical properties were obtained from the Colorado State University Regional Atmospehric Modeling System and represent a hailstorm observed during the 1986 Cooperative Huntsville Meteorological Experiment. These properties are used as input to a three-dimensional radiative transfer model in order to simulate satellite observation of the storm. The model output consists of upwelling brightness temperatures at several of the frequencies on the Special Sensor Microwave/Imager. The radiative transfer model accounts for scattering and emission of atmospheric gases and hydrometers in liquid and ice phases. Brightness temperatures obtained from the three-dimensional model of this investigation indicate that horizontal inhomogeneities give rise to brightness temperature fields that can be quite different from fields obtained using plane-parallel radiative transfer theory. These differences are examined for various resolutions of the satellite sensor field of view. In adddition, the issue of boundary conditions for three-dimensional atmospheric radiative transfer is addressed.

  7. Australian and New Zealand three-dimensional conformal radiation therapy consensus guidelines for prostate cancer.

    PubMed

    Skala, M; Berry, M; Duchesne, G; Gogna, K; Tai, K-H; Turner, S; Kneebone, A; Rolfo, A; Haworth, A

    2004-12-01

    Three-dimensional conformal radiation therapy (3DCRT) has been shown to reduce normal tissue toxicity and allow dose escalation in the curative treatment of prostate cancer. The Faculty of Radiation Oncology Genito-Urinary Group initiated a consensus process to generate evidence-based guidelines for the safe and effective implementation of 3DCRT. All radiation oncology departments in Australia and New Zealand were invited to complete a survey of their prostate practice and to send representatives to a consensus workshop. After a review of the evidence, key issues were identified and debated. If agreement was not reached, working parties were formed to make recommendations. Draft guidelines were circulated to workshop participants for approval prior to publication. Where possible, evidence-based recommendations have been made with regard to patient selection, risk stratification, simulation, planning, treatment delivery and toxicity reporting. This is the first time a group of radiation therapists, physicists and oncologists representing professional radiotherapy practice across Australia and New Zealand have worked together to develop best-practice guidelines. These guidelines should serve as a baseline for prospective clinical trials, outcome research and quality assurance.

  8. Three-Dimensional Mixed Convection Flow of Viscoelastic Fluid with Thermal Radiation and Convective Conditions

    PubMed Central

    Hayat, Tasawar; Ashraf, Muhammad Bilal; Alsulami, Hamed H.; Alhuthali, Muhammad Shahab

    2014-01-01

    The objective of present research is to examine the thermal radiation effect in three-dimensional mixed convection flow of viscoelastic fluid. The boundary layer analysis has been discussed for flow by an exponentially stretching surface with convective conditions. The resulting partial differential equations are reduced into a system of nonlinear ordinary differential equations using appropriate transformations. The series solutions are developed through a modern technique known as the homotopy analysis method. The convergent expressions of velocity components and temperature are derived. The solutions obtained are dependent on seven sundry parameters including the viscoelastic parameter, mixed convection parameter, ratio parameter, temperature exponent, Prandtl number, Biot number and radiation parameter. A systematic study is performed to analyze the impacts of these influential parameters on the velocity and temperature, the skin friction coefficients and the local Nusselt number. It is observed that mixed convection parameter in momentum and thermal boundary layers has opposite role. Thermal boundary layer is found to decrease when ratio parameter, Prandtl number and temperature exponent are increased. Local Nusselt number is increasing function of viscoelastic parameter and Biot number. Radiation parameter on the Nusselt number has opposite effects when compared with viscoelastic parameter. PMID:24608594

  9. Three-dimensional mixed convection flow of viscoelastic fluid with thermal radiation and convective conditions.

    PubMed

    Hayat, Tasawar; Ashraf, Muhammad Bilal; Alsulami, Hamed H; Alhuthali, Muhammad Shahab

    2014-01-01

    The objective of present research is to examine the thermal radiation effect in three-dimensional mixed convection flow of viscoelastic fluid. The boundary layer analysis has been discussed for flow by an exponentially stretching surface with convective conditions. The resulting partial differential equations are reduced into a system of nonlinear ordinary differential equations using appropriate transformations. The series solutions are developed through a modern technique known as the homotopy analysis method. The convergent expressions of velocity components and temperature are derived. The solutions obtained are dependent on seven sundry parameters including the viscoelastic parameter, mixed convection parameter, ratio parameter, temperature exponent, Prandtl number, Biot number and radiation parameter. A systematic study is performed to analyze the impacts of these influential parameters on the velocity and temperature, the skin friction coefficients and the local Nusselt number. It is observed that mixed convection parameter in momentum and thermal boundary layers has opposite role. Thermal boundary layer is found to decrease when ratio parameter, Prandtl number and temperature exponent are increased. Local Nusselt number is increasing function of viscoelastic parameter and Biot number. Radiation parameter on the Nusselt number has opposite effects when compared with viscoelastic parameter.

  10. Evaluating a three dimensional model of diffuse photosynthetically active radiation in maize canopies

    NASA Astrophysics Data System (ADS)

    Wang, Xiping; Guo, Yan; Li, Baoguo; Wang, Xiyong; Ma, Yuntao

    2006-07-01

    Diffuse photosynthetically active radiation (DPAR) is important during overcast days and for plant parts shaded from the direct beam radiation. Simulation of DPAR interception by individual plant parts of a canopy, separately from direct beam photosynthetically active radiation (PAR), may give important insights into plant ecology. This paper presents a model to simulate the interception of DPAR in plant canopies. A sub-model of a virtual maize canopy was reconstructed. Plant surfaces were represented as small triangular facets positioned according to three-dimensionally (3D) digitized data collected in the field. Then a second sub-model to simulate the 3D DPAR distribution in the canopy was developed by dividing the sky hemisphere into a grid of fine cells that allowed for the anisotropic distribution of DPAR over the sky hemisphere. This model, DSHP (Dividing Sky Hemisphere with Projecting), simulates which DSH (Divided Sky Hemisphere) cells are directly visible from a facet in the virtual canopy, i.e. not obscured by other facets. The DPAR reaching the center of a facet was calculated by summing the amounts of DPAR present in every DSH cell. The distribution of DPAR in a canopy was obtained from the calculated DPARs intercepted by all facets in the canopy. This DSHP model was validated against DPAR measurements made in an actual maize ( Zea mays L.) canopy over selected days during the early filling stage. The simulated and measured DPAR at different canopy depths showed a good agreement with a R 2 equaling 0.78 ( n=120).

  11. Dispersion engineering of metasurfaces for dual-frequency quasi-three-dimensional cloaking of microwave radiators.

    PubMed

    Jiang, Zhi Hao; Werner, Douglas H

    2016-05-01

    In this work, the design methodology and experimental investigation of compact and lightweight dispersive coatings, comprised by multiple layers of anisotropic metasurfaces, which are capable of cloaking radiators at multiple frequencies are presented. To determine the required surface electromagnetic properties for each layer, an analytical model is developed for predicting the scattering from a cylinder surrounded by multiple layers of anisotropic metasurfaces subject to plane-wave illumination at a general oblique incidence angle. Particularly, two different metasurface coating solutions with different dispersive properties are designed to provide more than 10 dB scattering width suppression at two pre-selected frequencies within a field-of-view (FOV) of ± 20° off normal incidence. Both coating designs implemented using metasurfaces are fabricated and measured, experimentally demonstrating the simultaneous suppression of mutual coupling and quasi-three-dimensional radiation blockage at the two pre-selected frequency ranges. At the same time, the functionality of the coated monopole is still well-maintained. The performance comparison further sheds light on how the optimal performance can be obtained by properly exploiting the dispersion of each metasurface layer of the coating. In addition, the cloaking effect is retained even when the distance between the radiators is significantly reduced. The concept and general design methodology presented here can be extended for applications that would benefit from cloaking multi-spectral terahertz as well as optical antennas. PMID:27137576

  12. Observations of Three-Dimensional Radiative Effects that Influence Satellite Retrievals of Cloud Properties

    NASA Technical Reports Server (NTRS)

    Varnai, Tamas; Marshak, Alexander; Lau, William K. M. (Technical Monitor)

    2001-01-01

    This paper examines three-dimensional (3D) radiative effects, which arise from horizontal radiative interactions between areas that have different cloud properties. Earlier studies have argued that these effects can cause significant uncertainties in current satellite retrievals of cloud properties, because the retrievals rely on one-dimensional (1D) theory and do not consider the effects of horizontal changes in cloud properties. This study addresses two questions: which retrieved cloud properties are influenced by 3D radiative effects, and where 3D effects tend to occur? The influence of 3D effects is detected from the wayside illumination and shadowing make clouds appear asymmetric: Areas appear brighter if the cloud top surface is tilted toward, rather than away from, the Sun. The analysis of 30 images by the Moderate Resolution Imaging Spectroradiometer (MODIS) reveals that retrievals of cloud optical thickness and cloud water content are most influenced by 3D effects, whereas retrievals of cloud particle size are much less affected. The results also indicate that while 3D effects are strongest at cloud edges, cloud top variability in cloud interiors, even in overcast regions, also produces considerable 3D effects. Finally, significant 3D effects are found in a wide variety of situations, ranging from thin clouds to thick ones and from low clouds to high ones.

  13. Dispersion engineering of metasurfaces for dual-frequency quasi-three-dimensional cloaking of microwave radiators.

    PubMed

    Jiang, Zhi Hao; Werner, Douglas H

    2016-05-01

    In this work, the design methodology and experimental investigation of compact and lightweight dispersive coatings, comprised by multiple layers of anisotropic metasurfaces, which are capable of cloaking radiators at multiple frequencies are presented. To determine the required surface electromagnetic properties for each layer, an analytical model is developed for predicting the scattering from a cylinder surrounded by multiple layers of anisotropic metasurfaces subject to plane-wave illumination at a general oblique incidence angle. Particularly, two different metasurface coating solutions with different dispersive properties are designed to provide more than 10 dB scattering width suppression at two pre-selected frequencies within a field-of-view (FOV) of ± 20° off normal incidence. Both coating designs implemented using metasurfaces are fabricated and measured, experimentally demonstrating the simultaneous suppression of mutual coupling and quasi-three-dimensional radiation blockage at the two pre-selected frequency ranges. At the same time, the functionality of the coated monopole is still well-maintained. The performance comparison further sheds light on how the optimal performance can be obtained by properly exploiting the dispersion of each metasurface layer of the coating. In addition, the cloaking effect is retained even when the distance between the radiators is significantly reduced. The concept and general design methodology presented here can be extended for applications that would benefit from cloaking multi-spectral terahertz as well as optical antennas.

  14. Three-dimensional simulation of wave-induced circulation: Comparison of three radiation stress formulations

    NASA Astrophysics Data System (ADS)

    Sheng, Y. Peter; Liu, Tianyi

    2011-05-01

    A three-dimensional current-wave modeling system, Curvilinear-grid Hydrodynamics 3D (CH3D)-Simulating Waves Nearshore (SWAN), has been used to simulate wave-induced circulation and compare the performances of three radiation stress (RS) formulations: two depth-dependent formulations (M08 by Mellor (2008) and X04 by Xia et al. (2004)) and one depth-independent formulation (LHS by Longuet-Higgins and Stewart (1964)). While all are based on linear wave theory, LHS uses the vertically integrated equations of motion, and M08 and X04 consider the three-dimensional equations of motion. Results of CH3D-SWAN with three RS formulations are compared with steady state wave setup, observed data in an undertow experiment by Ting and Kirby (1994) (TK94), and observed data in a laboratory fringing reef. All three RS formulations reproduce the analytical solution of wave setup very well. Simulated wave-induced currents and turbulence for TK94 are the best when M08 is used and worst when X04 is used, apparently due to the errors in the X04 formulation. All three RS formulations give good simulation of wave setup in the fringing reef. Wave-induced currents in the fringing reef simulated by the three RS formulations are quite different: M08 produces a single large clockwise gyre in the x-z plane, LHS produces a weaker gyre, and X04 produces a clockwise gyre plus a counterclockwise gyre inside the surf zone. Using the CH3D-Storm Surge Modeling System and M08, storm surge and currents in the Outer Banks and Chesapeake Bay during Hurricane Isabel are simulated. Compared to the earlier simulation obtained with the LHS, M08 produces similar storm surge but slightly improved the wave-induced currents.

  15. Three-dimensional radiation dose mapping with the TORT computer code

    SciTech Connect

    Slater, C.O.; Pace, J.V. III; Childs, R.L.; Haire, M.J. ); Koyama, T. )

    1991-01-01

    The Consolidated Fuel Reprocessing Program (CFRP) at Oak Ridge National Laboratory (ORNL) has performed radiation shielding studies in support of various facility designs for many years. Computer codes employing the point-kernel method have been used, and the accuracy of these codes is within acceptable limits. However, to further improve the accuracy and to calculate dose at a larger number of locations, a higher order method is desired, even for analyses performed in the early stages of facility design. Consequently, the three-dimensional discrete ordinates transport code TORT, developed at ORNL in the mid-1980s, was selected to examine in detail the dose received at equipment locations. The capabilities of the code have been previously reported. Recently, the Power Reactor and Nuclear Fuel Development Corporation in Japan and the US Department of Energy have used the TORT code as part of a collaborative agreement to jointly develop breeder reactor fuel reprocessing technology. In particular, CFRP used the TORT code to estimate radiation dose levels within the main process cell for a conceptual plant design and to establish process equipment lifetimes. The results reported in this paper are for a conceptual plant design that included the mechanical head and (i.e., the disassembly and shear machines), solvent extraction equipment, and miscellaneous process support equipment.

  16. PAKAL: A THREE-DIMENSIONAL MODEL TO SOLVE THE RADIATIVE TRANSFER EQUATION

    SciTech Connect

    De la Luz, Victor; Lara, Alejandro; Mendoza-Torres, J. E.; Selhorst, Caius L.

    2010-06-15

    We present a new numerical model called 'Pakal' intended to solve the radiative transfer equation in a three-dimensional (3D) geometry, using the approximation for a locally plane-parallel atmosphere. Pakal uses pre-calculated radial profiles of density and temperature (based on hydrostatic, hydrodynamic, or MHD models) to compute the emission from 3D source structures with high spatial resolution. Then, Pakal solves the radiative transfer equation in a set of (3D) ray paths, going from the source to the observer. Pakal uses a new algorithm to compute the radiative transfer equation by using an intelligent system consisting of three structures: a cellular automaton; an expert system; and a program coordinator. The code outputs can be either two-dimensional maps or one-dimensional profiles, which reproduce the observations with high accuracy, giving detailed physical information about the environment where the radiation was generated and/or transmitted. We present the model applied to a 3D solar radial geometry, assuming a locally plane-parallel atmosphere, and thermal free-free radio emission from hydrogen-helium gas in thermodynamic equilibrium. We also present the convergence test of the code. We computed the synthetic spectrum of the centimetric-millimetric solar emission and found better agreement with observations (up to 10{sup 4} K at 20 GHz) than previous models reported in the literature. The stability and convergence test show the high accuracy of the code. Finally, Pakal can improve the integration time by up to an order of magnitude compared against linear integration codes.

  17. Two- and three-dimensional models for risk assessment of radiation-enhanced colorectal tumorigenesis.

    PubMed

    Roig, Andres I; Hight, Suzie K; Shay, Jerry W

    2009-01-01

    Astronauts may be at an increased risk for developing colorectal cancer after a prolonged interplanetary mission given the potential for greater carcinogenic effects of radiation to the colon. In addition, with an increase in age, there is a greater incidence of premalignant colon adenomas with age. In the present study, we have compared the effects of radiation on human colon epithelial cells in two-dimensional (2D) monolayer culture, in three-dimensional (3D) culture, and in intact human colon tissue biopsies. Immortalized colon epithelial cells were irradiated at the NASA Space Radiation Laboratory (NSRL) with either 1 Gy 1 GeV/nucleon (56)Fe particles or 1 Gy 1 GeV/nucleon protons and were stained at various times to assess DNA damage and repair responses. The results show more persisting damage at 24 h with iron-particle radiation compared to protons. Similar results were seen in 3D colon epithelial cell cultures in which (56)Fe-particle-irradiated specimens show more persisting damage at 24 h than those irradiated with low-LET gamma rays. We compared these results to those obtained from human colon tissue biopsies irradiated with 1 Gy gamma rays or 1 Gy 1 GeV (56)Fe particles. Observations of radiation-induced DNA damage and repair in gamma-irradiated specimens revealed more pronounced early DNA damage responses in the epithelial cell compartment compared to the stromal cell compartment. After low-LET irradiation, the damage foci mostly disappeared at 24 h. Antibodies to more than one type of DNA repair factor display this pattern of DNA damage, and staining of nonirradiated cells with nonphosphorylated DNA-PKcs shows a predominance of epithelial staining over stromal cells. Biopsy specimens irradiated with high-LET radiations also show a pattern of predominance of the DNA damage response in the highly proliferative epithelial cell compartment. Persistent unrepaired DNA damage in colon epithelial cells and the differing repair responses between the epithelial

  18. A three-dimensional hybrid finite element/spectral analysis of noise radiation from turbofan inlets

    NASA Astrophysics Data System (ADS)

    Duta, M. C.; Giles, M. B.

    2006-09-01

    This paper describes a new three-dimensional (3D) analysis of tonal noise radiated from non-axisymmetric turbofan inlets. The novelty of the method is in combining a standard finite element discretisation of the acoustic field in the axial and radial coordinates with a Fourier spectral representation in the circumferential direction. The boundary conditions at the farfield, fan face and acoustic liners are treated using the same spectral representation. The resulting set of discrete acoustic equations are solved employing the well-established BICGSTAB or QMR iterative algorithms and a very effective specialised preconditioner based on the axisymmetric mean geometry and flow field. Numerical examples demonstrate the suitability of the new method to engine configurations with realistic 3D features, such as relatively large degrees of asymmetry and spliced acoustic liners. The examples also illustrate the two advantages of the new method over a traditional 3D finite element approach. The new method requires a significantly smaller number of unknowns as relatively few circumferential Fourier modes in the spectral solution ensure an accurate field representation. Also, due to the effective preconditioner, the spectral linear solver benefits from stable iterations at a high rate of convergence.

  19. Radiative Effect of Clouds on Tropospheric Chemistry in a Global Three-Dimensional Chemical Transport Model

    NASA Technical Reports Server (NTRS)

    Liu, Hongyu; Crawford, James H.; Pierce, Robert B.; Norris, Peter; Platnick, Steven E.; Chen, Gao; Logan, Jennifer A.; Yantosca, Robert M.; Evans, Mat J.; Kittaka, Chieko; Feng, Yan; Tie, Xuexi

    2006-01-01

    Clouds exert an important influence on tropospheric photochemistry through modification of solar radiation that determines photolysis frequencies (J-values). We assess the radiative effect of clouds on photolysis frequencies and key oxidants in the troposphere with a global three-dimensional (3-D) chemical transport model (GEOS-CHEM) driven by assimilated meteorological observations from the Goddard Earth Observing System data assimilation system (GEOS DAS) at the NASA Global Modeling and Assimilation Office (GMAO). We focus on the year of 2001 with the GEOS-3 meteorological observations. Photolysis frequencies are calculated using the Fast-J radiative transfer algorithm. The GEOS-3 global cloud optical depth and cloud fraction are evaluated and generally consistent with the satellite retrieval products from the Moderate Resolution Imaging Spectroradiometer (MODIS) and the International Satellite Cloud Climatology Project (ISCCP). Results using the linear assumption, which assumes linear scaling of cloud optical depth with cloud fraction in a grid box, show global mean OH concentrations generally increase by less than 6% because of the radiative effect of clouds. The OH distribution shows much larger changes (with maximum decrease of approx.20% near the surface), reflecting the opposite effects of enhanced (weakened) photochemistry above (below) clouds. The global mean photolysis frequencies for J[O1D] and J[NO2] in the troposphere change by less than 5% because of clouds; global mean O3 concentrations in the troposphere increase by less than 5%. This study shows tropical upper tropospheric O3 to be less sensitive to the radiative effect of clouds than previously reported (approx.5% versus approx.20-30%). These results emphasize that the dominant effect of clouds is to influence the vertical redistribution of the intensity of photochemical activity while global average effects remain modest, again contrasting with previous studies. Differing vertical distributions

  20. Scattering of electromagnetic radiation by three-dimensional periodic arrays of identical particles.

    PubMed

    Xu, Yu-Lin

    2014-02-01

    The generalized multiparticle Mie-solution (GMM), a Lorenz-Mie-type rigorous theory for the scattering of a monochromatic plane wave by an arbitrary configuration of nonintersecting scattering bodies, has lately been revisited and further developed. A recent progress is the initiation of a special version applied to one- and two-dimensional (1D and 2D) periodic arrays (PAs) of identical particles [J. Opt. Soc. Am. A30, 1053 (2013)]. As a continuous advance, the present work extends the initiative PA-type solution from 1D and 2D to the more involved three-dimensional (3D) regular arrays. Analytical formulations applicable to the 3D PAs are derived, including the special PA-type explicit expressions for cross sections of extinction, scattering, backscattering, and radiation pressure. The specific PA-version is a complement to the general formulation and solution process of the standard GMM. In either 1D and 2D or 3D cases, the newly devised PA-approach is capable of providing expeditiously theoretical predictions of radiative scattering characteristics for periodic structures consisting of a huge number of identical unit cells, which the general approach of the GMM is unable to handle in practical calculations, owing to excessive computing time and/or computer memory requirements. To illustrate practical applications, sample numerical solutions obtained via the PA-approach are shown for 3D PAs of finite lengths that have ∼5×10(7) component particles, including structures having a rectangular opening. Also discussed is potential future work on the theory and its tests.

  1. Cell Type-dependent Gene Transcription Profile in Three Dimensional Human Skin Tissue Model Exposed to Low Doses of Ionizing Radiation: Implications for Medical Exposures

    SciTech Connect

    Freiin von Neubeck, Claere H.; Shankaran, Harish; Karin, Norman J.; Kauer, Paula M.; Chrisler, William B.; Wang, Xihai; Robinson, Robert J.; Waters, Katrina M.; Tilton, Susan C.; Sowa, Marianne B.

    2012-04-17

    The concern over possible health risks from exposures to low doses of ionizing radiation has been driven largely by the increase in medical exposures, the routine implementation of X-ray backscatter devices for airport security screening, and, most recently, the nuclear incident in Japan. Due to a paucity of direct epidemiological data at very low doses, cancer risk must be estimated from high dose exposure scenarios. However, there is increasing evidence that low and high dose exposures result in different signaling events and may have different mechanisms of cancer induction. We have examined the radiation induced temporal response of an in vitro three dimensional (3D) human skin tissue model using microarray-based transcriptional profiling. Our data shows that exposure to 100 mGy of X-rays is sufficient to affect gene transcription. Cell type specific analysis showed significant changes in gene expression with the levels of > 1400 genes altered in the dermis and > 400 genes regulated in the epidermis. The two cell types rarely exhibited overlapping responses at the mRNA level. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) measurements validated the microarray data in both regulation direction and value. Key pathways identified relate to cell cycle regulation, immune responses, hypoxia, reactive oxygen signaling, and DNA damage repair. We discuss in particular the role of proliferation and emphasizing how the disregulation of cellular signaling in normal tissue may impact progression towards radiation induced secondary diseases.

  2. Laser-processed three dimensional graphitic electrodes for diamond radiation detectors

    NASA Astrophysics Data System (ADS)

    Caylar, Benoît; Pomorski, Michal; Bergonzo, Philippe

    2013-07-01

    We have used an original approach for diamond detectors where three dimensional buried graphitic electrodes are processed in the bulk of a diamond substrate via laser-induced graphitization. Prototype made of polycrystalline chemical vapor deposition diamond was fabricated using a nanosecond UV laser. Its charge collection efficiency was evaluated using α-particles emitted by a 241-Americium source. An improved charge collection efficiency was measured proving that laser micro-machining of diamond is a valid option for the future fabrication of three dimensional diamond detectors.

  3. Laser-processed three dimensional graphitic electrodes for diamond radiation detectors

    SciTech Connect

    Caylar, Benoı-carett; Pomorski, Michal; Bergonzo, Philippe

    2013-07-22

    We have used an original approach for diamond detectors where three dimensional buried graphitic electrodes are processed in the bulk of a diamond substrate via laser-induced graphitization. Prototype made of polycrystalline chemical vapor deposition diamond was fabricated using a nanosecond UV laser. Its charge collection efficiency was evaluated using α-particles emitted by a 241-Americium source. An improved charge collection efficiency was measured proving that laser micro-machining of diamond is a valid option for the future fabrication of three dimensional diamond detectors.

  4. Carcinoma of the anal canal: Intensity modulated radiation therapy (IMRT) versus three-dimensional conformal radiation therapy (3DCRT)

    PubMed Central

    Sale, Charlotte; Moloney, Phillip; Mathlum, Maitham

    2013-01-01

    Introduction Patients with anal canal carcinoma treated with standard conformal radiotherapy frequently experience severe acute and late toxicity reactions to the treatment area. Roohipour et al. (Dis Colon Rectum 2008; 51: 147–53) stated a patient's tolerance of chemoradiation to be an important prediction of treatment success. A new intensity modulated radiation therapy (IMRT) technique for anal carcinoma cases has been developed at the Andrew Love Cancer Centre aimed at reducing radiation to surrounding healthy tissue. Methods A same-subject repeated measures design was used for this study, where five anal carcinoma cases at the Andrew Love Cancer Centre were selected. Conformal and IMRT plans were generated and dosimetric evaluations were performed. Each plan was prescribed a total of 54 Gray (Gy) over a course of 30 fractions to the primary site. Results The IMRT plans resulted in improved dosimetry to the planning target volume (PTV) and reduction in radiation to the critical structures (bladder, external genitalia and femoral heads). Statistically there was no difference between the IMRT and conformal plans in the dose to the small and large bowel; however, the bowel IMRT dose–volume histogram (DVH) doses were consistently lower. Conclusion The IMRT plans were superior to the conformal plans with improved dose conformity and reduced radiation to the surrounding healthy tissue. Anecdotally it was found that patients tolerated the IMRT treatment better than the three-dimensional (3D) conformal radiation therapy. This study describes and compares the planning techniques. PMID:26229623

  5. Carcinoma of the anal canal: Intensity modulated radiation therapy (IMRT) versus three-dimensional conformal radiation therapy (3DCRT)

    SciTech Connect

    Sale, Charlotte; Moloney, Phillip; Mathlum, Maitham

    2013-12-15

    Patients with anal canal carcinoma treated with standard conformal radiotherapy frequently experience severe acute and late toxicity reactions to the treatment area. Roohipour et al. (Dis Colon Rectum 2008; 51: 147–53) stated a patient's tolerance of chemoradiation to be an important prediction of treatment success. A new intensity modulated radiation therapy (IMRT) technique for anal carcinoma cases has been developed at the Andrew Love Cancer Centre aimed at reducing radiation to surrounding healthy tissue. A same-subject repeated measures design was used for this study, where five anal carcinoma cases at the Andrew Love Cancer Centre were selected. Conformal and IMRT plans were generated and dosimetric evaluations were performed. Each plan was prescribed a total of 54 Gray (Gy) over a course of 30 fractions to the primary site. The IMRT plans resulted in improved dosimetry to the planning target volume (PTV) and reduction in radiation to the critical structures (bladder, external genitalia and femoral heads). Statistically there was no difference between the IMRT and conformal plans in the dose to the small and large bowel; however, the bowel IMRT dose–volume histogram (DVH) doses were consistently lower. The IMRT plans were superior to the conformal plans with improved dose conformity and reduced radiation to the surrounding healthy tissue. Anecdotally it was found that patients tolerated the IMRT treatment better than the three-dimensional (3D) conformal radiation therapy. This study describes and compares the planning techniques.

  6. Long-Term Outcomes After High-Dose Postprostatectomy Salvage Radiation Treatment

    SciTech Connect

    Goenka, Anuj; Magsanoc, Juan Martin; Pei Xin; Schechter, Michael; Kollmeier, Marisa; Cox, Brett; Scardino, Peter T.; Eastham, James A.; Zelefsky, Michael J.

    2012-09-01

    Purpose: To review the impact of high-dose radiotherapy (RT) in the postprostatectomy salvage setting on long-term biochemical control and distant metastases-free survival, and to identify clinical and pathologic predictors of outcomes. Methods and Materials: During 1988-2007, 285 consecutive patients were treated with salvage RT (SRT) after radical prostatectomy. All patients were treated with either three-dimensional conformal RT or intensity-modulated RT. Two hundred seventy patients (95%) were treated to a dose {>=}66 Gy, of whom 205 (72%) received doses {>=}70 Gy. Eighty-seven patients (31%) received androgen-deprivation therapy as a component of their salvage treatment. All clinical and pathologic records were reviewed to identify treatment risk factors and response. Results: The median follow-up time after SRT was 60 months. Seven-year actuarial prostate-specific antigen (PSA) relapse-free survival and distant metastases-free survival were 37% and 77%, respectively. Independent predictors of biochemical recurrence were vascular invasion (p < 0.01), negative surgical margins (p < 0.01), presalvage PSA level >0.4 ng/mL (p < 0.01), androgen-deprivation therapy (p = 0.03), Gleason score {>=}7 (p = 0.02), and seminal vesicle involvement (p = 0.05). Salvage RT dose {>=}70 Gy was not associated with improvement in biochemical control. A doubling time <3 months was the only independent predictor of metastatic disease (p < 0.01). There was a trend suggesting benefit of SRT dose {>=}70 Gy in preventing clinical local failure in patients with radiographically visible local disease at time of SRT (7 years: 90% vs. 79.1%, p = 0.07). Conclusion: Salvage RT provides effective long-term biochemical control and freedom from metastasis in selected patients presenting with detectable PSA after prostatectomy. Androgen-deprivation therapy was associated with improvement in biochemical progression-free survival. Clinical local failures were rare but occurred most commonly in

  7. Gene expression profiling in undifferentiated thyroid carcinoma induced by high-dose radiation

    PubMed Central

    Bang, Hyun Soon; Choi, Moo Hyun; Kim, Cha Soon; Choi, Seung Jin

    2016-01-01

    Published gene expression studies for radiation-induced thyroid carcinogenesis have used various methodologies. In this study, we identified differential gene expression in a human thyroid epithelial cell line after exposure to high-dose γ-radiation. HTori-3 cells were exposed to 5 or 10 Gy of ionizing radiation using two dose rates (high-dose rate: 4.68 Gy/min, and low-dose rate: 40 mGy/h) and then implanted into the backs of BALB/c nude mice after 4 (10 Gy) or 5 weeks (5 Gy). Decreases in cell viability, increases in giant cell frequency, anchorage-independent growth in vitro, and tumorigenicity in vivo were observed. Particularly, the cells irradiated with 5 Gy at the high-dose rate or 10 Gy at the low-dose rate demonstrated more prominent tumorigenicity. Gene expression profiling was analyzed via microarray. Numerous genes that were significantly altered by a fold-change of >50% following irradiation were identified in each group. Gene expression analysis identified six commonly misregulated genes, including CRYAB, IL-18, ZNF845, CYP24A1, OR4N4 and VN1R4, at all doses. These genes involve apoptosis, the immune response, regulation of transcription, and receptor signaling pathways. Overall, the altered genes in high-dose rate (HDR) 5 Gy and low-dose rate (LDR) 10 Gy were more than those of LDR 5 Gy and HDR 10 Gy. Thus, we investigated genes associated with aggressive tumor development using the two dosage treatments. In this study, the identified gene expression profiles reflect the molecular response following high doses of external radiation exposure and may provide helpful information about radiation-induced thyroid tumors in the high-dose range. PMID:27006382

  8. Statistics Analysis of the Uncertainties in Cloud Optical Depth Retrievals Caused by Three-Dimensional Radiative Effects

    NASA Technical Reports Server (NTRS)

    Varnai, Tamas; Marshak, Alexander

    2000-01-01

    This paper presents a simple approach to estimate the uncertainties that arise in satellite retrievals of cloud optical depth when the retrievals use one-dimensional radiative transfer theory for heterogeneous clouds that have variations in all three dimensions. For the first time, preliminary error bounds are set to estimate the uncertainty of cloud optical depth retrievals. These estimates can help us better understand the nature of uncertainties that three-dimensional effects can introduce into retrievals of this important product of the MODIS instrument. The probability distribution of resulting retrieval errors is examined through theoretical simulations of shortwave cloud reflection for a wide variety of cloud fields. The results are used to illustrate how retrieval uncertainties change with observable and known parameters, such as solar elevation or cloud brightness. Furthermore, the results indicate that a tendency observed in an earlier study, clouds appearing thicker for oblique sun, is indeed caused by three-dimensional radiative effects.

  9. Thermoluminescence glow-curve characteristics of LiF phosphors at high doses of gamma radiation

    NASA Astrophysics Data System (ADS)

    Benny, P. G.; Khader, S. A.; Sarma, K. S. S.

    2013-05-01

    High doses of ionising radiation are becoming increasingly common for radiation-processing applications of various medical, agricultural and polymer products using gamma and electron beams. The objective of this work was to study thermoluminescence (TL) glow-curve characteristics of commonly used commercial LiF TL phosphors at high doses of radiation with a view to use them in dosimetry of radiation-processing applications. The TL properties of TLD 100 and 700 phosphors, procured from the Thermo-Scientific (previously Harshaw) company, have been studied in the dose range of 1-60 kGy. The shift in glow peaks was observed in this dose range. Integral TL responses of TLD 100 and TLD 700 were found to decrease as a linear function of dose in the range of 5-50 kGy. The paper describes initial results related to the glow-curve characteristics of these phosphors.

  10. Three dimensional radiation dosimetry in lung-equivalent regions by use of a radiation sensitive gel foam: Proof of principle

    SciTech Connect

    Deene, Yves de; Vergote, Koen; Claeys, Carolien; De Wagter, Carlos

    2006-07-15

    A polymer hydrogel foam is proposed as a potential three dimensional experimental dosimeter for radiation treatment verification in low-density tissue such as the lung. A gel foam is created by beating a radiation sensitive polymer gel mixture in an anoxic atmosphere. The mass density of the gel foam is in the order of 0.25-0.35 kg/dm{sup 3}. Both nuclear magnetic resonance (NMR) spin-spin relaxation rate (R2) and magnetization transfer ratio (MTR) have been used to map the dose distribution from the gel dosimeter. It is found that MTR has significant advantages compared to R2 for mapping the dose distribution in the polymer gel foam dosimeters. The magnetization transfer ratio is found to be less dependent on the density and microstructure of the gel foam dosimeter while spin-spin relaxation dispersion has been observed making the spin-spin relaxation rate dependent on the interecho time interval. Optical microscopy reveals a microstructure that shows great similarity with human lung tissue. It is also shown how NMR hydrogen proton density measurements can be used to map the density distributions in gel dosimeters.

  11. Nanotube-based three-dimensional albumin composite obtained using continuous laser radiation

    SciTech Connect

    Ageeva, S. A.; Bobrinetskii, I. I.; Nevolin, V. K. Podgaetskii, V. M.; Selishchev, S. V.; Simunin, M. M.; Konov, V. I.; Savranskii, V. V.

    2009-12-15

    The possibility of developing three-dimensional nanostructures for damaged bone and tissue restoration, including treatment of human congenital malformation is considered. Four types of multiwalled and single-walled carbon nanotubes fabricated by chemical vapor deposition via disproportionation on Fe clusters and thermal cathode sputtering in an inert gas were studied. The nanomaterial's topography was studied by atomic-force microscopy. The possibility of using 3D nanocomposites as a biosolder for laser biowelding of cartilaginous tissue was shown. The compatibility of biological tissues with a nanocomposite material in vivo introduced under the perichondrium of ear cartilage of a rabbit was validated.

  12. Three-dimensional simulation of guided-wave second-harmonic generation in the form of coherent Cerenkov radiation.

    PubMed

    Hayata, K; Koshiba, M

    1991-10-15

    We implement a direct three-dimensional calculation of Cerenkov-radiation-type frequency doubling in an optical channel waveguide by using a finite-element guided-beam simulator. The simulator can predict an optimum configuration and the conversion efficiency of miniaturized frequency doublers that utilize guided-to-radiation-mode interactions in nonlinear channel waveguides. Computed results are shown for blue-light generation through the frequency doubling in a proton-exchanged MgO:LiNbO(3) channel waveguide. PMID:19777032

  13. A finite element-boundary integral method for scattering and radiation by two- and three-dimensional structures

    NASA Technical Reports Server (NTRS)

    Jin, Jian-Ming; Volakis, John L.; Collins, Jeffery D.

    1991-01-01

    A review of a hybrid finite element-boundary integral formulation for scattering and radiation by two- and three-dimensional composite structures is presented. In contrast to other hybrid techniques involving the finite element method, the proposed one is in principle exact and can be implemented using a low O(N) storage. This is of particular importance for large scale applications and is a characteristic of the boundary chosen to terminate the finite element mesh, usually as close to the structure as possible. A certain class of these boundaries lead to convolutional boundary integrals which can be evaluated via the fast Fourier transform (FFT) without a need to generate a matrix; thus, retaining the O(N) storage requirement. The paper begins with a general description of the method. A number of two- and three-dimensional applications are then given, including numerical computations which demonstrate the method's accuracy, efficiency, and capability.

  14. Three Dimensional Radiation Transport Analyses in Pwr with Tort and Mcnp

    NASA Astrophysics Data System (ADS)

    Fukuya, Koji; Nakata, Hayato; Kimura, Itsuro; Kitagawa, Hideo; Ohmura, Masaki; Ito, Taku; Shin, Kazuo

    2003-06-01

    Three dimensional (3D) neutron and gamma calculations for structural materials inside the reactor vessel in a commercial PWR were performed using the 3D transport code TORT and the Monte Carlo code MCNP to assess the accuracy of calculations using these codes and libraries. Comparisons with two dimensional DORT calculations with various libraries and surveillance dosimetry measurements indicated that TORT and MCNP calculations give similar agreements with surveillance measurements to DORT calculations. Influences of the cross section data, ENDF/B-IV, ENDF/B-VI and JENDL3.2 on attenuation of the fast flux and dpa rate in the reactor vessel, relative contributions of gamma-rays and thermal neutrons to dpa were discussed.

  15. Micro-fabrication by laser radiation forces: a direct route to reversible free-standing three-dimensional structures.

    PubMed

    Athanasekos, Loukas; Vasileiadis, Miltiadis; Mantzaridis, Christos; Karoutsos, Vagelis C; Koutselas, Ioannis; Pispas, Stergios; Vainos, Nikolaos A

    2012-10-22

    The origins and first demonstration of structurally stable solids formed by use of radiation forces are presented. By experimentally proving that radiation forces can indeed produce stable solid material forms, a novel method enabling two- and three-dimensional (2d and 3d) microfabrication is introduced: An optical, non-contact single-step physical operation, reversible with respect to materials nature, based on the sole use of radiation forces. The present innovation is elucidated by the formation of polyisoprene and polybutadiene micro-solids, as well as plasmonic and fluorescent hybrids, respectively comprising Au nanoparticles and CdS quantum dots, together with novel concepts of polymeric fiber-drawing by radiation forces. PMID:23187237

  16. Effect of high doses of gamma radiation on the functional characteristics of amniotic membrane

    NASA Astrophysics Data System (ADS)

    Singh, Rita; Purohit, Sumita; Chacharkar, M. P.

    2007-06-01

    The effect of different doses of gamma radiation viz. 25, 36 and 50 kGy on the chemical and functional characteristics of the amniotic membrane was studied. The change in the chemical structure of amniotic membranes at high doses of gamma irradiation was evaluated by means of Infrared (IR) Spectroscopy. The degradation of amnion on irradiation with gamma rays could produce a relative variation in IR absorption troughs. This kind of variation was absent in the samples irradiated to doses of 25, 36 and 50 kGy indicating no qualitative change in the material property of amnion. No significant differences in the water absorption capacity and water vapour transmission rate of amniotic membranes irradiated to different doses were observed. Impermeability of the amniotic membranes to different microorganisms was also not affected at high doses of gamma radiation. Gamma irradiation at doses of 25-50 kGy did not evoke undesirable changes in the functional properties of the amniotic membrane.

  17. Advances in three-dimensional conformal radiation therapy physics with intensity modulation.

    PubMed

    Webb, S

    2000-09-01

    Intensity-modulated radiation therapy, a specific form of conformal radiation therapy, is currently attracting a lot of attention, and there are high expectations for this class of treatment techniques. Several new technologies are in development, but physicists are still working to improve the physical basis of radiation therapy.

  18. Electron beam requirements for a three-dimensional Smith-Purcell backward-wave oscillator for intense terahertz radiation.

    SciTech Connect

    Kim, K.-J.; Kumar, V.; Accelerator Systems Division; Raja Ramanna Center for Advanced Tech.

    2007-08-01

    A Smith-Purcell device can operate as a backward-wave oscillator for intense, narrow-bandwidth, continuous wave radiation at terahertz wavelengths. We determine the requirements on electron beam current and emittance for the system to oscillate based on a three-dimensional extension of our previous two-dimensional analysis. It is found that specially designed electron beams are required with a current that exceeds a certain threshold value and a flat transverse profile that allows the beam to travel very close to the grating surface. Two methods for producing electron beams with the required characteristics are discussed.

  19. Three-dimensional conformal intensity-modulated radiation therapy of left femur foci does not damage the sciatic nerve

    PubMed Central

    Xu, Wanlong; Zhao, Xibin; Wang, Qing; Sun, Jungang; Xu, Jiangbo; Zhou, Wenzheng; Wang, Hao; Yan, Shigui; Yuan, Hong

    2014-01-01

    During radiotherapy to kill femoral hydatid tapeworms, the sciatic nerve surrounding the focus can be easily damaged by the treatment. Thus, it is very important to evaluate the effects of radiotherapy on the surrounding nervous tissue. In the present study, we used three-dimensional, conformal, intensity-modulated radiation therapy to treat bilateral femoral hydatid disease in Meriones meridiani. The focus of the hydatid disease on the left femur was subjected to radiotherapy (40 Gy) for 14 days, and the right femur received sham irradiation. Hematoxylin-eosin staining, electron microscopy, and terminal deoxynucleotidyl transferase-dUTP nick end labeling assays on the left femurs showed that the left sciatic nerve cell structure was normal, with no obvious apoptosis after radiation. Trypan blue staining demonstrated that the overall protoscolex structure in bone parasitized with Echinococcus granulosus disappeared in the left femur of the animals after treatment. The mortality of the protoscolex was higher in the left side than in the right side. The succinate dehydrogenase activity in the protoscolex in bone parasitized with Echinococcus granulosus was lower in the left femur than in the right femur. These results suggest that three-dimensional conformal intensity-modulated radiation therapy achieves good therapeutic effects on the secondary bone in hydatid disease in Meriones meridiani without damaging the morphology or function of the sciatic nerve. PMID:25422645

  20. Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation.

    PubMed

    Shao, Lijian; Sun, Yan; Zhang, Zhonghui; Feng, Wei; Gao, Yongxing; Cai, Zailong; Wang, Zack Z; Look, A Thomas; Wu, Wen-Shu

    2010-06-10

    Bone marrow injury is a major adverse side effect of radiation and chemotherapy. Attempts to limit such damage are warranted, but their success requires a better understanding of how radiation and anticancer drugs harm the bone marrow. Here, we report one pivotal role of the BH3-only protein Puma in the radiosensitivity of hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs). Puma deficiency in mice confers resistance to high-dose radiation in a hematopoietic cell-autonomous manner. Unexpectedly, loss of one Puma allele is sufficient to confer mice radioresistance. Interestingly, null mutation in Puma protects both primitive and differentiated hematopoietic cells from damage caused by low-dose radiation but selectively protects HSCs and HPCs against high-dose radiation, thereby accelerating hematopoietic regeneration. Consistent with these findings, Puma is required for radiation-induced apoptosis in HSCs and HPCs, and Puma is selectively induced by irradiation in primitive hematopoietic cells, and this induction is impaired in Puma-heterozygous cells. Together, our data indicate that selective targeting of p53 downstream apoptotic targets may represent a novel strategy to protecting HSCs and HPCs in patients undergoing intensive cancer radiotherapy and chemotherapy.

  1. Comparison of low and high dose ionising radiation using topological analysis of gene coexpression networks

    PubMed Central

    2012-01-01

    Background The growing use of imaging procedures in medicine has raised concerns about exposure to low-dose ionising radiation (LDIR). While the disastrous effects of high dose ionising radiation (HDIR) is well documented, the detrimental effects of LDIR is not well understood and has been a topic of much debate. Since little is known about the effects of LDIR, various kinds of wet-lab and computational analyses are required to advance knowledge in this domain. In this paper we carry out an “upside-down pyramid” form of systems biology analysis of microarray data. We characterised the global genomic response following 10 cGy (low dose) and 100 cGy (high dose) doses of X-ray ionising radiation at four time points by analysing the topology of gene coexpression networks. This study includes a rich experimental design and state-of-the-art computational systems biology methods of analysis to study the differences in the transcriptional response of skin cells exposed to low and high doses of radiation. Results Using this method we found important genes that have been linked to immune response, cell survival and apoptosis. Furthermore, we also were able to identify genes such as BRCA1, ABCA1, TNFRSF1B, MLLT11 that have been associated with various types of cancers. We were also able to detect many genes known to be associated with various medical conditions. Conclusions Our method of applying network topological differences can aid in identifying the differences among similar (eg: radiation effect) yet very different biological conditions (eg: different dose and time) to generate testable hypotheses. This is the first study where a network level analysis was performed across two different radiation doses at various time points, thereby illustrating changes in the cellular response over time. PMID:22594378

  2. Dispersion characteristics of three-dimensional dielectric-loaded grating for terahertz Smith-Purcell radiation

    SciTech Connect

    Cao, Miaomiao Li, Ke; Liu, Wenxin Wang, Yong

    2014-02-15

    In this paper, a dielectric-loaded grating for Smith-Purcell device is proposed. The three-dimensional (3D) analytical theory for hot dispersion relation is obtained by using field matched method, which is solved by numerical simulations. The first and second order growth rates for the proposal model are analyzed, which is obtained by expanding hot dispersion equation at the operating point. The results show that the dispersion can be effectively weakened by introducing dielectric-loaded grating, in which the cutoff frequency is affected by the grating thickness. The dispersion curve becomes flatter and shifts towards lower frequency at the optimum grating parameters. The 3D particle-in-cell (PIC) simulation is also performed and the results are in good agreement with theoretical calculations. Comparing the first order growth rate with the second one, it reveals that the discrepancy is small when electron beam parameters are selected with small values. Otherwise, the discrepancy is large and cannot be ignored. To accurately describe the process of beam-wave interaction, the second order growth rate is necessary to apply.

  3. Dispersion characteristics of three-dimensional dielectric-loaded grating for terahertz Smith-Purcell radiation

    NASA Astrophysics Data System (ADS)

    Cao, Miaomiao; Liu, Wenxin; Wang, Yong; Li, Ke

    2014-02-01

    In this paper, a dielectric-loaded grating for Smith-Purcell device is proposed. The three-dimensional (3D) analytical theory for hot dispersion relation is obtained by using field matched method, which is solved by numerical simulations. The first and second order growth rates for the proposal model are analyzed, which is obtained by expanding hot dispersion equation at the operating point. The results show that the dispersion can be effectively weakened by introducing dielectric-loaded grating, in which the cutoff frequency is affected by the grating thickness. The dispersion curve becomes flatter and shifts towards lower frequency at the optimum grating parameters. The 3D particle-in-cell (PIC) simulation is also performed and the results are in good agreement with theoretical calculations. Comparing the first order growth rate with the second one, it reveals that the discrepancy is small when electron beam parameters are selected with small values. Otherwise, the discrepancy is large and cannot be ignored. To accurately describe the process of beam-wave interaction, the second order growth rate is necessary to apply.

  4. Natural element method for solving radiative transfer with or without conduction in three-dimensional complex geometries

    NASA Astrophysics Data System (ADS)

    Zhang, Yong; Ma, Yu; Yi, Hong-Liang; Tan, He-Ping

    2013-11-01

    A meshless method called as the natural element method (NEM) is developed for solving radiative heat transfer problem in 3D complex enclosures filled with an absorbing, emitting and scattering medium. The boundary surfaces are supposed to be opaque, diffuse as well as gray. The shape functions used in NEM are constructed by the natural neighbor interpolations, which are strictly interpolant and the essential boundary conditions can be imposed directly. The NEM solutions dealing with the radiative heat transfer with or without conduction are validated by comparison with some cases reported by the literature. Furthermore, the radiative heat transfer in cubic enclosures with or without an inner hollow sphere, cylinder and elliptical cylinder is also examined to demonstrate the applicability of the present method towards various three-dimensional geometries. For pure radiative transfer, both the cases of radiative non-equilibrium and radiative equilibrium are investigated. For combined conduction and radiation heat transfer, effects of various parameters such as the conduction-radiation parameter, the scattering albedo, the extinction coefficient, and the boundary emissivity are analyzed on the temperature distributions.

  5. Delayed activation of human microglial cells by high dose ionizing radiation.

    PubMed

    Chen, Hongxin; Chong, Zhao Zhong; De Toledo, Sonia M; Azzam, Edouard I; Elkabes, Stella; Souayah, Nizar

    2016-09-01

    Recent studies have shown that microglia affects the fate of neural stem cells in response to ionizing radiation, which suggests a role for microglia in radiation-induced degenerative outcomes. We therefore investigated the effects of γ-irradiation on cell survival, proliferation, and activation of microglia and explored associated mechanisms. Specifically, we evaluated cellular and molecular changes associated with exposure of human microglial cells (CHME5) to low and high doses of acute cesium-137 γ rays. Twenty-four hours after irradiation, cell cycle analyses revealed dose-dependent decreases in the fraction of cells in S and G2/M phase, which correlated with significant oxidative stress. By one week after irradiation, 20-30% of the cells exposed to high doses of γ rays underwent apoptosis, which correlated with significant concomitant decrease in metabolic activity as assessed by the MTT assay, and microglial activation as judged by both morphological changes and increased expression of Glut-5 and CR43. These changes were associated with increases in the mRNA levels for IL-1α, IL-10 and TNFα. Together, the results show that human CHME5 microglia are relatively resistant to low and moderate doses of γ rays, but are sensitive to acute high doses, and that CHME5 cells are a useful tool for in vitro study of human microglia. PMID:27265419

  6. Three-Dimensional Conformal Radiation Therapy for Esophageal Squamous Cell Carcinoma: Is Elective Nodal Irradiation Necessary?

    SciTech Connect

    Zhao Kuaile; Ma Jinbo; Liu Guang; Wu Kailiang; Shi Xuehui; Jiang Guoliang

    2010-02-01

    Purpose: To evaluate the local control, survival, and toxicity associated with three-dimensional conformal radiotherapy (3D-CRT) for squamous cell carcinoma (SCC) of the esophagus, to determine the appropriate target volumes, and to determine whether elective nodal irradiation is necessary in these patients. Methods and Materials: A prospective study of 3D-CRT was undertaken in patients with esophageal SCC without distant metastases. Patients received 68.4 Gy in 41 fractions over 44 days using late-course accelerated hyperfractionated 3D-CRT. Only the primary tumor and positive lymph nodes were irradiated. Isolated out-of-field regional nodal recurrence was defined as a recurrence in an initially uninvolved regional lymph node. Results: All 53 patients who made up the study population tolerated the irradiation well. No acute or late Grade 4 or 5 toxicity was observed. The median survival time was 30 months (95% confidence interval, 17.7-41.8). The overall survival rate at 1, 2, and 3 years was 77%, 56%, and 41%, respectively. The local control rate at 1, 2, and 3 years was 83%, 74%, and 62%, respectively. Thirty-nine of the 53 patients (74%) showed treatment failure. Seventeen of the 39 (44%) developed an in-field recurrence, 18 (46%) distant metastasis with or without regional failure, and 3 (8%) an isolated out-of-field nodal recurrence only. One patient died of disease in an unknown location. Conclusions: In patients treated with 3D-CRT for esophageal SCC, the omission of elective nodal irradiation was not associated with a significant amount of failure in lymph node regions not included in the planning target volume. Local failure and distant metastases remained the predominant problems.

  7. Three-dimensional tomographic imaging for dynamic radiation behavior study using infrared imaging video bolometers in large helical device plasma.

    PubMed

    Sano, Ryuichi; Peterson, Byron J; Teranishi, Masaru; Iwama, Naofumi; Kobayashi, Masahiro; Mukai, Kiyofumi; Pandya, Shwetang N

    2016-05-01

    A three-dimensional (3D) tomography system using four InfraRed imaging Video Bolometers (IRVBs) has been designed with a helical periodicity assumption for the purpose of plasma radiation measurement in the large helical device. For the spatial inversion of large sized arrays, the system has been numerically and experimentally examined using the Tikhonov regularization with the criterion of minimum generalized cross validation, which is the standard solver of inverse problems. The 3D transport code EMC3-EIRENE for impurity behavior and related radiation has been used to produce phantoms for numerical tests, and the relative calibration of the IRVB images has been carried out with a simple function model of the decaying plasma in a radiation collapse. The tomography system can respond to temporal changes in the plasma profile and identify the 3D dynamic behavior of radiation, such as the radiation enhancement that starts from the inboard side of the torus, during the radiation collapse. The reconstruction results are also consistent with the output signals of a resistive bolometer. These results indicate that the designed 3D tomography system is available for the 3D imaging of radiation. The first 3D direct tomographic measurement of a magnetically confined plasma has been achieved.

  8. Membrane Signaling Induced by High Doses of Ionizing Radiation in the Endothelial Compartment. Relevance in Radiation Toxicity

    PubMed Central

    Corre, Isabelle; Guillonneau, Maëva; Paris, François

    2013-01-01

    Tumor areas can now be very precisely delimited thanks to technical progress in imaging and ballistics. This has also led to the development of novel radiotherapy protocols, delivering higher doses of ionizing radiation directly to cancer cells. Despite this, radiation toxicity in healthy tissue remains a major issue, particularly with dose-escalation in these new protocols. Acute and late tissue damage following irradiation have both been linked to the endothelium irrigating normal tissues. The molecular mechanisms involved in the endothelial response to high doses of radiation are associated with signaling from the plasma membrane, mainly via the acid sphingomyelinase/ceramide pathway. This review describes this signaling pathway and discusses the relevance of targeting endothelial signaling to protect healthy tissues from the deleterious effects of high doses of radiation. PMID:24252908

  9. Silicon-based three-dimensional microstructures for radiation dosimetry in hadrontherapy

    SciTech Connect

    Guardiola, C. Solberg, T.; Carabe, A.; Quirion, D.; Pellegrini, G.; Fleta, C.; Esteban, S.; Lozano, M.; Cortés-Giraldo, M. A.; Gómez, F.

    2015-07-13

    In this work, we propose a solid-state-detector for use in radiation microdosimetry. This device improves the performance of existing dosimeters using customized 3D-cylindrical microstructures etched inside silicon. The microdosimeter consists of an array of micro-sensors that have 3D-cylindrical electrodes of 15 μm diameter and a depth of 5 μm within a silicon membrane, resulting in a well-defined micrometric radiation sensitive volume. These microdetectors have been characterized using an {sup 241}Am source to assess their performance as radiation detectors in a high-LET environment. This letter demonstrates the capability of this microdetector to be used to measure dose and LET in hadrontherapy centers for treatment plan verification as part of their patient-specific quality control program.

  10. Radiation Effect On Three Dimensional Vertical Channel Flow Through Porous Medium

    NASA Astrophysics Data System (ADS)

    Guria, M.

    2015-12-01

    The flow of a viscous incompressible fluid through a vertical channel in the presence of radiation immersed in a porous medium has been studied. Approximate solutions have been obtained for the velocity and temperature fields, shear stresses and rate of heat transfer using the perturbation technique. It is found that the primary velocity decreases with an increase in the radiation parameter as well as the Prandtl number for cooling of the plate. It is also found that with an increase in the permeability parameter, the primary velocity increases for cooling of the plate. The magnitude of the secondary velocity decreases near the plate y = 0 and increases near the plate y = d with an increase in the permeability parameter. The temperature distribution decreases with an increase of the radiation parameter as wall as the Prandtl number for cooling of the plate. The shear stresses and the rate of heat transfer, which are of physical interest, are presented in the form of tables.

  11. A three dimensional radiative transfer method for optical remote sensing of vegetated land surfaces

    NASA Technical Reports Server (NTRS)

    Asrar, Ghassem; Myneni, Ranga B.; Choudhury, Bhaskar J.

    1991-01-01

    In the application of remote sensing at optical wavelengths to vegetated surfaces from satellite borne high resolution instruments, an understanding of the various physical mechanisms that contribute to the measured signal is important. A numerical method of solving the radiative transfer equation in three dimensions is reported. The reliability of coding and accuracy of the algorithm are evaluated by benchmarching. Parametrization of the methods and results of a simulation are presented. The method is tested with experimental data of canopy bidirectional reflectance factors. The effect of spatial heterogeneity on the relationship between the simple ratio and normalized vrs absorbed Photosynthetically Active Radiation (PAR) is discussed.

  12. New lattice Boltzmann method for the simulation of three-dimensional radiation transfer in turbid media.

    PubMed

    McHardy, Christopher; Horneber, Tobias; Rauh, Cornelia

    2016-07-25

    Based on the kinetic theory of photons, a new lattice Boltzmann method for the simulation of 3D radiation transport is presented. The method was successfully validated with Monte Carlo simulations of radiation transport in optical thick absorbing and non-absorbing turbid media containing either isotropic or anisotropic scatterers. Moreover, for the approximation of Mie-scattering, a new iterative algebraic approach for the discretization of the scattering phase function was developed, ensuring full conservation of energy and asymmetry after discretization. It was found that the main error sources of the method are caused by linearization and ray effects and suggestions for further improvement of the method are made. PMID:27464152

  13. Radiation dose delivered to the proximal penis as a predictor of the risk of erectile dysfunction after three-dimensional conformal radiotherapy for localized prostate cancer

    SciTech Connect

    Wernicke, A. Gabriella; Valicenti, Richard . E-mail: richard.valicenti@mail.tju.edu; DiEva, Kelly; Houser, Christopher; Pequignot, Ed

    2004-12-01

    Purpose/objective: In this study, we evaluated in a serial manner whether radiation dose to the bulb of the penis is predictive of erectile dysfunction, ejaculatory difficulty (EJ), and overall satisfaction with sex life (quality of life) by using serial validated self-administered questionnaires. Methods and materials: Twenty-nine potent men with AJCC Stage II prostate cancer treated with three-dimensional conformal radiation therapy alone to a median dose 72.0 Gy (range: 66.6-79.2 Gy) were evaluated by determining the doses received by the penile bulb. The penile bulb was delineated volumetrically, and the dose-volume histogram was obtained on each patient. Results: The median follow-up time was 35 months (range, 16-43 months). We found that for D{sub 30}, D{sub 45}, D{sub 60}, and D{sub 75} (doses to a percent volume of PB: 30%, 45%, 60%, and 75%), higher than the corresponding median dose (defined as high-dose group) correlated with an increased risk of impotence (erectile dysfunction firmness score = 0) (odds ratio [OR] = 7.5, p = 0.02; OR = 7.5, p = 0.02; OR = 8.6, p = 0.008; and OR = 6.9, p = 0.015, respectively). Similarly, for EJD D{sub 30}, D{sub 45}, D{sub 60}, and D{sub 75}, doses higher than the corresponding median ones correlated with worsening ejaculatory function score (EJ = 0 or 1) (OR = 8, p = 0.013; OR = 8, p 0.013; OR = 9.2, p = 0.015; and OR = 8, p = 0.026, respectively). For quality of life, low ({<=}median dose) dose groups of patients improve over time, whereas high-dose groups of patients worsen. Conclusions: This study supports the existence of a penile bulb dose-volume relationship underlying the development of radiation-induced erectile dysfunction. Our data may guide the use of inverse treatment planning to maximize the probability of maintaining sexual potency after radiation therapy.

  14. Dyed acrylic-acid grafted polypropylene films for high-dose radiation dosimetry

    NASA Astrophysics Data System (ADS)

    Abdel-Fattah, A. A.; Said, F. I. A.; Ebraheem, S.; El-Kelany, M.; El Miligy, A. A.

    1999-03-01

    Gamma radiation-induced polymerization of acrylic acid (AAc) onto polypropylene (PP) film has been carried out under nitrogen atmosphere. The grafted film of PP-g-PAAc was allowed to react with solutions of two ionic dyes, namely malachite green (MALG) or methylene green (METG). The investigations show that these new dosimeter films of PPMALG and PPMETG may be useful for high-dose gamma radiation applications. The useful absorbed dose range of the dyed films extends up to about 400 kGy, with a minimum useful dose of about 5 kGy. The radiation-induced colour bleaching has been analyzed with visible spectrophotometry, either at the maximum of the absorption band peaking at 601 nm (for PPMETG) or that peaking at 623 nm for (PPMALG). The effects of relative humidity during irradiation, shelf-life and post-irradiation storage in dark and indirect daylight conditions on dosimeters performance are discussed.

  15. Radiation Parameterization for Three-Dimensional Inhomogeneous Cirrus Clouds Applied to ARM Data and Climate Models

    SciTech Connect

    Kuo-Nan Liou

    2003-12-29

    OAK-B135 (a) We developed a 3D radiative transfer model to simulate the transfer of solar and thermal infrared radiation in inhomogeneous cirrus clouds. The model utilized a diffusion approximation approach (four-term expansion in the intensity) employing Cartesian coordinates. The required single-scattering parameters, including the extinction coefficient, single-scattering albedo, and asymmetry factor, for input to the model, were parameterized in terms of the ice water content and mean effective ice crystal size. The incorporation of gaseous absorption in multiple scattering atmospheres was accomplished by means of the correlated k-distribution approach. In addition, the strong forward diffraction nature in the phase function was accounted for in each predivided spatial grid based on a delta-function adjustment. The radiation parameterization developed herein is applied to potential cloud configurations generated from GCMs to investigate broken clouds and cloud-overlapping effects on the domain-averaged heating rate. Cloud inhomogeneity plays an important role in the determination of flux and heating rate distributions. Clouds with maximum overlap tend to produce less heating than those with random overlap. Broken clouds show more solar heating as well as more IR cooling as compared to a continuous cloud field (Gu and Liou, 2001). (b) We incorporated a contemporary radiation parameterization scheme in the UCLA atmospheric GCM in collaboration with the UCLA GCM group. In conjunction with the cloud/radiation process studies, we developed a physically-based cloud cover formation scheme in association with radiation calculations. The model clouds were first vertically grouped in terms of low, middle, and high types. Maximum overlap was then used for each cloud type, followed by random overlap among the three cloud types. Fu and Liou's 1D radiation code with modification was subsequently employed for pixel-by-pixel radiation calculations in the UCLA GCM. We showed

  16. The effects of high dose and highly fractionated radiation on distraction osteogenesis in the murine mandible.

    PubMed

    Monson, Laura A; Cavaliere, Christi M; Deshpande, Sagar S; Ayzengart, Alexander L; Buchman, Steven R

    2012-09-07

    The ability of irradiated tissue to support bony growth remains poorly defined, although there are anecdotal cases reported showing mixed results for the use of mandibular distraction osteogenesis after radiation for head and neck cancer. Many of these reports lack objective measures that would allow adequate analysis of outcomes or efficacy. The purpose of this experiment was to utilize a rat model of mandibular distraction osteogenesis after high dose and highly fractionated radiation therapy and to evaluate and quantify distracted bone formation under these conditions. Male Sprague-Dawley rats underwent 12 fractions of external beam radiation (48 Gray) of the left mandible. Following a two week recovery period, an external frame distractor was applied and gradual distraction of the mandible was performed. Tissue was harvested after a twenty-eight day consolidation period. Gross, radiologic and histological evaluations were undertaken. Those animals subjected to pre-operative radiation showed severe attenuation of bone formation including bone atrophy, incomplete bridging of the distraction gap, and gross bony defects or non-union. Although physical lengthening was achieved, the irradiated bone consistently demonstrated marked damaging effects on the normal process of distraction osteogenesis. This murine model has provided reliable evidence of the injurious effects of high dose radiation on bone repair and regeneration in distraction osteogenesis utilizing accurate and reproducible metrics. These results can now be used to assist in the development of therapies directed at mitigating the adverse consequences of radiation on the regeneration of bone and to optimize distraction osteogenesis so it can be successfully applied to post-oncologic reconstruction.

  17. Three-dimensional relativistic pair plasma reconnection with radiative feedback in the Crab Nebula

    SciTech Connect

    Cerutti, B.; Werner, G. R.; Uzdensky, D. A.; Begelman, M. C. E-mail: greg.werner@colorado.edu E-mail: mitch@jila.colorado.edu

    2014-02-20

    The discovery of rapid synchrotron gamma-ray flares above 100 MeV from the Crab Nebula has attracted new interest in alternative particle acceleration mechanisms in pulsar wind nebulae. Diffuse shock-acceleration fails to explain the flares because particle acceleration and emission occur during a single or even sub-Larmor timescale. In this regime, the synchrotron energy losses induce a drag force on the particle motion that balances the electric acceleration and prevents the emission of synchrotron radiation above 160 MeV. Previous analytical studies and two-dimensional (2D) particle-in-cell (PIC) simulations indicate that relativistic reconnection is a viable mechanism to circumvent the above difficulties. The reconnection electric field localized at X-points linearly accelerates particles with little radiative energy losses. In this paper, we check whether this mechanism survives in three dimension (3D), using a set of large PIC simulations with radiation reaction force and with a guide field. In agreement with earlier works, we find that the relativistic drift kink instability deforms and then disrupts the layer, resulting in significant plasma heating but few non-thermal particles. A moderate guide field stabilizes the layer and enables particle acceleration. We report that 3D magnetic reconnection can accelerate particles above the standard radiation reaction limit, although the effect is less pronounced than in 2D with no guide field. We confirm that the highest-energy particles form compact bunches within magnetic flux ropes, and a beam tightly confined within the reconnection layer, which could result in the observed Crab flares when, by chance, the beam crosses our line of sight.

  18. Three-dimensional Relativistic Pair Plasma Reconnection with Radiative Feedback in the Crab Nebula

    NASA Astrophysics Data System (ADS)

    Cerutti, B.; Werner, G. R.; Uzdensky, D. A.; Begelman, M. C.

    2014-02-01

    The discovery of rapid synchrotron gamma-ray flares above 100 MeV from the Crab Nebula has attracted new interest in alternative particle acceleration mechanisms in pulsar wind nebulae. Diffuse shock-acceleration fails to explain the flares because particle acceleration and emission occur during a single or even sub-Larmor timescale. In this regime, the synchrotron energy losses induce a drag force on the particle motion that balances the electric acceleration and prevents the emission of synchrotron radiation above 160 MeV. Previous analytical studies and two-dimensional (2D) particle-in-cell (PIC) simulations indicate that relativistic reconnection is a viable mechanism to circumvent the above difficulties. The reconnection electric field localized at X-points linearly accelerates particles with little radiative energy losses. In this paper, we check whether this mechanism survives in three dimension (3D), using a set of large PIC simulations with radiation reaction force and with a guide field. In agreement with earlier works, we find that the relativistic drift kink instability deforms and then disrupts the layer, resulting in significant plasma heating but few non-thermal particles. A moderate guide field stabilizes the layer and enables particle acceleration. We report that 3D magnetic reconnection can accelerate particles above the standard radiation reaction limit, although the effect is less pronounced than in 2D with no guide field. We confirm that the highest-energy particles form compact bunches within magnetic flux ropes, and a beam tightly confined within the reconnection layer, which could result in the observed Crab flares when, by chance, the beam crosses our line of sight.

  19. Long-term androgen deprivation increases Grade 2 and higher late morbidity in prostate cancer patients treated with three-dimensional conformal radiation therapy

    SciTech Connect

    Feigenberg, Steven J. . E-mail: S_Feigenberg@fccc.edu; Hanlon, Alexandra L.; Horwitz, Eric M.; Uzzo, Robert G.; Eisenberg, Debra; Pollack, Alan

    2005-06-01

    Purpose: To determine whether the use of androgen deprivation (AD) increases late morbidity when combined with high-dose three-dimensional conformal radiation therapy (3D-CRT). Methods and materials: Between May 1989 and November 1998, 1,204 patients were treated for prostate cancer with 3D-CRT to a median dose of 74 Gy. Patients were evaluated every 3-6 months. No AD was given to 945 patients, whereas 140 and 119 patients, respectively, received short-term AD (STAD; {<=}6 months) and long-term AD (LTAD; > 6 months). Radiation morbidity was graded according to the Fox Chase modification of the Late Effects Normal Tissue Task Force late morbidity scale. Covariates in the multivariate analysis (MVA) included age, history of diabetes mellitus, prostate-specific antigen (PSA) level, Gleason score, T category, RT field size, total RT dose, use of rectal shielding, and AD status (no AD vs. STAD vs. LTAD). Results: The only independent predictor for Grade 2 or higher genitourinary (GU) morbidity in the MVA was the use of AD (p = 0.0065). The 5-year risk of Grade 2 or higher GU morbidity was 8% for no AD, 8% for STAD, and 14% for LTAD (p = 0.02). Independent predictors of Grade 2 or higher gastrointestinal (GI) morbidity in the MVA were the use of AD (p = 0.0079), higher total radiation dose (p < 0.0001), the lack of a rectal shield (p = 0.0003), and older age (p = 0.0009). The 5-year actuarial risk of Grade 2 or higher GI morbidity was 17% for no AD vs. 18% for STAD and 26% for LTAD (p = 0.017). Conclusions: The use of LTAD seems to significantly increase the risk of both GU and GI morbidity for patients treated with 3D-CRT.

  20. Comparative outcomes for three-dimensional conformal versus intensity-modulated radiation therapy for esophageal cancer.

    PubMed

    Freilich, J; Hoffe, S E; Almhanna, K; Dinwoodie, W; Yue, B; Fulp, W; Meredith, K L; Shridhar, R

    2015-01-01

    Emerging data suggests a benefit for using intensity modulated radiation therapy (IMRT) for the management of esophageal cancer. We retrospectively reviewed patients treated at our institution who received definitive or preoperative chemoradiation with either IMRT or 3D conformal radiation therapy (3DCRT) between October 2000 and January 2012. Kaplan Meier analysis and the Cox proportional hazard model were used to evaluate survival outcomes. We evaluated a total of 232 patients (138 IMRT, 94 3DCRT) who received a median dose of 50.4 Gy (range, 44-64.8) to gross disease. Median follow up for all patients, IMRT patients alone, and 3DCRT patients alone was 18.5 (range, 2.5-124.2), 16.5 (range, 3-59), and 25.9 months (range, 2.5-124.2), respectively. We observed no significant difference based on radiation technique (3DCRT vs. IMRT) with respect to median overall survival (OS) (median 29 vs. 32 months; P = 0.74) or median relapse free survival (median 20 vs. 25 months; P = 0.66). On multivariable analysis (MVA), surgical resection resulted in improved OS (HR 0.444; P < 0.0001). Superior OS was also associated on MVA with stage I/II disease (HR 0.523; P = 0.010) and tumor length ≤5 cm (HR 0.567; P = 0.006). IMRT was also associated on univariate analysis with a significant decrease in acute weight loss (mean 6% + 4.3% vs 9% + 7.4%, P = 0.012) and on MVA with a decrease in objective grade ≥3 toxicity, defined as any hospitalization, feeding tube, or >20% weight loss (OR 0.51; P = 0.050). Our data suggest that while IMRT-based chemoradiation for esophageal cancer does not impact survival there was significantly less toxicity. In the IMRT group there was significant decrease in weight loss and grade ≥3 toxicity compared to 3DCRT.

  1. A model for radiative transfer in heterogeneous three-dimensional canopies

    NASA Technical Reports Server (NTRS)

    Goel, N. S.; Grier, T.

    1988-01-01

    A model, dubbed TRIM, for the interaction of electromagnetic radiation with inhomogeneous vegetation canopies is presented. It is based on the four flux theory for homogeneous canopies. The canopy is assumed to consist of ellipsoidal subcanopies located on the ground at periodic intervals. The model is inverted with field measured data for reflectance from corn canopies in the near infrared region. It is shown that TRIM correctly identifies the architecture of the canopy (homogeneous or row canopy, percentage of ground cover) and gives a good estimate of leaf area index.

  2. A Novel Implementation of Massively Parallel Three Dimensional Monte Carlo Radiation Transport

    NASA Astrophysics Data System (ADS)

    Robinson, P. B.; Peterson, J. D. L.

    2005-12-01

    The goal of our summer project was to implement the difference formulation for radiation transport into Cosmos++, a multidimensional, massively parallel, magneto hydrodynamics code for astrophysical applications (Peter Anninos - AX). The difference formulation is a new method for Symbolic Implicit Monte Carlo thermal transport (Brooks and Szöke - PAT). Formerly, simultaneous implementation of fully implicit Monte Carlo radiation transport in multiple dimensions on multiple processors had not been convincingly demonstrated. We found that a combination of the difference formulation and the inherent structure of Cosmos++ makes such an implementation both accurate and straightforward. We developed a "nearly nearest neighbor physics" technique to allow each processor to work independently, even with a fully implicit code. This technique coupled with the increased accuracy of an implicit Monte Carlo solution and the efficiency of parallel computing systems allows us to demonstrate the possibility of massively parallel thermal transport. This work was performed under the auspices of the U.S. Department of Energy by University of California Lawrence Livermore National Laboratory under contract No. W-7405-Eng-48

  3. Spot Radiative Ignition and Subsequent Three Dimensional Flame Spread Over Thin Cellulose Fuels

    NASA Technical Reports Server (NTRS)

    Olson, Sandra L.; Kashiwagi, T.; Kikuchi, M.; Fujita, O.; Ito, K.

    1999-01-01

    Spontaneous radiative ignition and transition to flame spread over thin cellulose fuel samples was studied aboard the USMP-3 STS-75 Space Shuttle mission, and in three test series in the 10 second Japan Microgravity Center (JAMIC). A focused beam from a tungsten/halogen lamp was used to ignite the center of the fuel sample while an external air flow was varied from 0 to 10 cm/s. Non-piloted radiative ignition of the paper was found to occur more easily in microgravity than in normal gravity. Ignition of the sample was achieved under all conditions studied (shuttle cabin air, 21%-50% O2 in JAMIC), with transition to flame spread occurring for all but the lowest oxygen and flow conditions. While radiative ignition in a quiescent atmosphere was achieved, the flame quickly extinguished in air. The ignition delay time was proportional to the gas-phase mixing time, which is estimated using the inverse flow rate. The ignition delay was a much stronger function of flow at lower oxygen concentrations. After ignition, the flame initially spread only upstream, in a fan-shaped pattern. The fan angle increased with increasing external flow and oxygen concentration from zero angle (tunneling flame spread) at the limiting 0.5 cm/s external air flow, to 90 degrees (semicircular flame spread) for external flows at and above 5 cm/s, and higher oxygen concentrations. The fan angle was shown to be directly related to the limiting air flow velocity. Despite the convective heating from the upstream flame, the downstream flame was inhibited due to the 'oxygen shadow' of the upstream flame for the air flow conditions studied. Downstream flame spread rates in air, measured after upstream flame spread was complete and extinguished, were slower than upstream flame spread rates at the same flow. The quench regime for the transition to flame spread was skewed toward the downstream, due to the augmenting role of diffusion for opposed flow flame spread, versus the canceling effect of diffusion

  4. High-dose MVCT image guidance for stereotactic body radiation therapy

    SciTech Connect

    Westerly, David C.; Schefter, Tracey E.; Kavanagh, Brian D.; Chao, Edward; Lucas, Dan; Flynn, Ryan T.; Miften, Moyed

    2012-08-15

    Purpose: Stereotactic body radiation therapy (SBRT) is a potent treatment for early stage primary and limited metastatic disease. Accurate tumor localization is essential to administer SBRT safely and effectively. Tomotherapy combines helical IMRT with onboard megavoltage CT (MVCT) imaging and is well suited for SBRT; however, MVCT results in reduced soft tissue contrast and increased image noise compared with kilovoltage CT. The goal of this work was to investigate the use of increased imaging doses on a clinical tomotherapy machine to improve image quality for SBRT image guidance. Methods: Two nonstandard, high-dose imaging modes were created on a tomotherapy machine by increasing the linear accelerator (LINAC) pulse rate from the nominal setting of 80 Hz, to 160 Hz and 300 Hz, respectively. Weighted CT dose indexes (wCTDIs) were measured for the standard, medium, and high-dose modes in a 30 cm solid water phantom using a calibrated A1SL ion chamber. Image quality was assessed from scans of a customized image quality phantom. Metrics evaluated include: contrast-to-noise ratios (CNRs), high-contrast spatial resolution, image uniformity, and percent image noise. In addition, two patients receiving SBRT were localized using high-dose MVCT scans. Raw detector data collected after each scan were used to reconstruct standard-dose images for comparison. Results: MVCT scans acquired using a pitch of 1.0 resulted in wCTDI values of 2.2, 4.7, and 8.5 cGy for the standard, medium, and high-dose modes respectively. CNR values for both low and high-contrast materials were found to increase with the square root of dose. Axial high-contrast spatial resolution was comparable for all imaging modes at 0.5 lp/mm. Image uniformity was improved and percent noise decreased as the imaging dose increased. Similar improvements in image quality were observed in patient images, with decreases in image noise being the most notable. Conclusions: High-dose imaging modes are made possible on a

  5. Polarized radiance fields under a dynamic ocean surface: a three-dimensional radiative transfer solution

    SciTech Connect

    You Yu; Zhai Pengwang; Kattawar, George W.; Yang Ping

    2009-06-01

    The hybrid matrix operator, Monte Carlo (HMOMC) method previously reported [Appl. Opt.47, 1063-1071 (2008)APOPAI0003-693510.1364/AO.47.001063] is improved by neglecting higher-order terms in the coupling of the matrix operators and by introducing a dual grid scheme. The computational efficiency for solving the vector radiative transfer equation in a full 3D coupled atmosphere-surface-ocean system is substantially improved, and, thus, large-scale simulations of the radiance distribution become feasible. The improved method is applied to the computation of the polarized radiance field under realistic surface waves simulated by the power spectral density method. To the authors' best knowledge, this is the first time that the polarized radiance field under a dynamic ocean surface and the underwater image of an object above such an ocean surface have been reported.

  6. Nondestructive three-dimensional evaluation of biocompatible materials by microtomography using synchrotron radiation

    NASA Astrophysics Data System (ADS)

    Muller, Bert; Thurner, Philipp; Beckmann, Felix; Weitkamp, Timm; Rau, Christoph; Bernhardt, Ricardo; Karamuk, Erdal; Eckert, Ludwig; Brandt, J.; Buchloh, Stefan; Wintermantel, Erich; Scharnweber, Dieter; Worch, Hartmut

    2002-01-01

    Microtomography based on synchrotron radiation sources is a unique technique for the 3D characterization of different materials with a spatial resolution down to about 1 micrometers . The interface between implant materials (metals, ceramics and polymers) and biological matter is nondestructively accessible, i.e. without preparation artifacts. Since the materials exhibit different x-ray absorption, it can become impossible to visualize implant material and tissue, simultaneously. Here, we show that coating of polymer implants, which are invisible in bone tissue, does not only improve the interfacial properties but also allows the imaging of the interface in detail. Titanium implants, on the other hand, absorb the x-rays stronger than bone tissue. The difference, however, is small enough to quantify the bone formation near interface. Another advantage of microtomography with respect to classical histology is the capability to examine samples in a hydrated state. We demonstrate that ceramic hollow spheres can be imaged before sintering and fibroblasts marked by OsO4 are visible on polymer textiles. Consequently, scaffolds of different materials designed for tissue engineering and implant coatings can be optimized on the basis of the tomograms.

  7. CHEMISTRY IN THE FIRST HYDROSTATIC CORE STAGE BY ADOPTING THREE-DIMENSIONAL RADIATION HYDRODYNAMIC SIMULATIONS

    SciTech Connect

    Furuya, Kenji; Aikawa, Yuri; Tomida, Kengo; Tomisaka, Kohji; Matsumoto, Tomoaki; Saigo, Kazuya; Hersant, Franck; Wakelam, Valentine

    2012-10-20

    We investigate molecular evolution from a molecular cloud core to a first hydrostatic core in three spatial dimensions. We perform a radiation hydrodynamic simulation in order to trace fluid parcels, in which molecular evolution is investigated, using a gas-phase and grain-surface chemical reaction network. We derive spatial distributions of molecular abundances and column densities in the molecular cloud core harboring the first core. We find that the total gas and ice abundances of many species in a cold era (10 K) remain unaltered until the temperature reaches {approx}500 K. The gas abundances in the warm envelope and the outer layer of the first core (T {approx}< 500 K) are mainly determined via the sublimation of ice-mantle species. Above 500 K, the abundant molecules, such as H{sub 2}CO, start to be destroyed, and simple molecules, such as CO, H{sub 2}O, and N{sub 2}, are reformed. On the other hand, some molecules are effectively formed at high temperature; carbon chains, such as C{sub 2}H{sub 2} and cyanopolyynes, are formed at temperatures >700 K. We also find that large organic molecules, such as CH{sub 3}OH and HCOOCH{sub 3}, are associated with the first core (r {approx}< 10 AU). Although the abundances of these molecules in the first core stage are comparable to or less than in the protostellar stage (hot corino), reflecting the lower luminosity of the central object, their column densities in our model are comparable to the observed values toward the prototypical hot corino, IRAS 16293-2422. We propose that these large organic molecules can be good tracers of the first cores.

  8. Radiation tolerant nanocrystalline ZrN films under high dose heavy-ion irradiations

    NASA Astrophysics Data System (ADS)

    Jiao, L.; Yu, K. Y.; Chen, D.; Jacob, C.; Shao, L.; Zhang, X.; Wang, H.

    2015-04-01

    ZrN, a refractory ceramic material, finds many potential applications in advanced nuclear reactors. However, the grain size dependent radiation response in nanocrystalline (nc) ZrN under high dose heavy ion irradiation has not yet been studied to date. Here, we compare the radiation response of nc-ZrN films (with a respective average grain size of ˜9 and 31 nm) to Fe2+ ion irradiations up to a damage level of 10 displacements-per-atom (dpa). The ZrN film with the average grain size of 9 nm shows prominently enhanced radiation tolerance as evidenced by suppressed grain growth, alleviated radiation softening, as well as reduced variation in electrical resistivity. In contrast, ZrN with the larger average grain size of 31 nm shows prominent radiation softening and resistivity increase, attributed to the high density of defect cluster formed inside the grains. The influence of grain boundaries on enhanced irradiation tolerance in nc-ZrN is discussed.

  9. Radiation tolerant nanocrystalline ZrN films under high dose heavy-ion irradiations

    SciTech Connect

    Jiao, L.; Wang, H.; Yu, K. Y.; Chen, D.; Jacob, C.; Shao, L.; Zhang, X.

    2015-04-14

    ZrN, a refractory ceramic material, finds many potential applications in advanced nuclear reactors. However, the grain size dependent radiation response in nanocrystalline (nc) ZrN under high dose heavy ion irradiation has not yet been studied to date. Here, we compare the radiation response of nc-ZrN films (with a respective average grain size of ∼9 and 31 nm) to Fe{sup 2+} ion irradiations up to a damage level of 10 displacements-per-atom (dpa). The ZrN film with the average grain size of 9 nm shows prominently enhanced radiation tolerance as evidenced by suppressed grain growth, alleviated radiation softening, as well as reduced variation in electrical resistivity. In contrast, ZrN with the larger average grain size of 31 nm shows prominent radiation softening and resistivity increase, attributed to the high density of defect cluster formed inside the grains. The influence of grain boundaries on enhanced irradiation tolerance in nc-ZrN is discussed.

  10. Application of the multigrid method in a deterministic solution scheme for the three-dimensional radiative transfer equation

    NASA Astrophysics Data System (ADS)

    Ishida, Haruma

    2014-01-01

    An improved solution scheme is developed for the three-dimensional radiative transfer equation (RTE) in inhomogeneous cloudy atmospheres. This solution scheme is deterministic (explicit) and utilizes spherical harmonics series expansion and the finite-volume method for discretization of the RTE. The first-order upwind finite difference is modified to take into account bidirectional flow of radiance in spherical harmonics space, and an iterative solution method is applied. The multigrid method, which is generally employed to achieve rapid convergence in iterative calculation, is incorporated into the solution scheme. The present study suggests that the restriction and prolongation procedure for the multigrid method must be also modified to account for bidirectional flow, and proposes an efficient bidirectional restriction/prolongation procedure that does not increase the computational effort for coarser grids, resulting in a type of wavelet low-pass filter. Several calculation examples for various atmosphere models indicate that the proposed solution scheme is effective for rapid convergence and suitable for obtaining adequate radiation fields in inhomogeneous cloudy atmospheres, although a comparison with the Monte Carlo method suggests that the radiances obtained by this solution scheme at certain angles tends to be smoother.

  11. Radiation-induced liver disease in three-dimensional conformal radiation therapy for primary liver carcinoma: The risk factors and hepatic radiation tolerance

    SciTech Connect

    Liang Shixiong; Zhu Xiaodong; Xu Zhiyong

    2006-06-01

    Purpose: To identify risk factors relevant to radiation-induced liver disease (RILD) and to determine the hepatic tolerance to radiation. Methods and Materials: The data of 109 primary liver carcinomas (PLC) treated with hypofractionated three-dimensional conformal radiation therapy (3D-CRT) were analyzed. Seventeen patients were diagnosed with RILD and 13 of 17 died of it. Results: The risk factors for RILD were late T stage, large gross tumor volume, presence of portal vein thrombosis, association with Child-Pugh Grade B cirrhosis, and acute hepatic toxicity. Multivariate analyses demonstrated that the severity of hepatic cirrhosis was a unique independent predictor. For Child-Pugh Grade A patients, the hepatic radiation tolerance was as follows: (1) Mean dose to normal liver (MDTNL) of 23 Gy was tolerable. (2) For cumulative dose-volume histogram, the tolerable volume percentages would be less than: V{sub 5} of 86%, V{sub 1} of 68%, V{sub 15} of 59%, V{sub 2} of 49%, V{sub 25} of 35%, V{sub 3} of 28%, V{sub 35} of 25%, and V{sub 4} of 20%. (3) Tolerable MDTNL could be estimated by MDTNL (Gy) = -1.686 + 0.023 * normal liver volume (cm{sup 3}). Conclusion: The predominant risk factor for RILD was the severity of hepatic cirrhosis. The hepatic tolerance to radiation could be estimated by dosimetric parameters.

  12. Implementation and modification of a three-dimensional radiation stress formulation for surf zone and rip-current applications

    USGS Publications Warehouse

    Kumar, N.; Voulgaris, G.; Warner, J.C.

    2011-01-01

    Regional Ocean Modeling System (ROMS v 3.0), a three-dimensional numerical ocean model, was previously enhanced for shallow water applications by including wave-induced radiation stress forcing provided through coupling to wave propagation models (SWAN, REF/DIF). This enhancement made it suitable for surf zone applications as demonstrated using examples of obliquely incident waves on a planar beach and rip current formation in longshore bar trough morphology (Haas and Warner, 2009). In this contribution, we present an update to the coupled model which implements a wave roller model and also a modified method of the radiation stress term based on Mellor (2008, 2011a,b,in press) that includes a vertical distribution which better simulates non-conservative (i.e., wave breaking) processes and appears to be more appropriate for sigma coordinates in very shallow waters where wave breaking conditions dominate. The improvements of the modified model are shown through simulations of several cases that include: (a) obliquely incident spectral waves on a planar beach; (b) obliquely incident spectral waves on a natural barred beach (DUCK'94 experiment); (c) alongshore variable offshore wave forcing on a planar beach; (d) alongshore varying bathymetry with constant offshore wave forcing; and (e) nearshore barred morphology with rip-channels. Quantitative and qualitative comparisons to previous analytical, numerical, laboratory studies and field measurements show that the modified model replicates surf zone recirculation patterns (onshore drift at the surface and undertow at the bottom) more accurately than previous formulations based on radiation stress (Haas and Warner, 2009). The results of the model and test cases are further explored for identifying the forces operating in rip current development and the potential implication for sediment transport and rip channel development. Also, model analysis showed that rip current strength is higher when waves approach at angles of 5

  13. General-Relativistic Three-Dimensional Multi-group Neutrino Radiation-Hydrodynamics Simulations of Core-Collapse Supernovae

    NASA Astrophysics Data System (ADS)

    Roberts, Luke F.; Ott, Christian D.; Haas, Roland; O’Connor, Evan P.; Diener, Peter; Schnetter, Erik

    2016-11-01

    We report on a set of long-term general-relativistic three-dimensional (3D) multi-group (energy-dependent) neutrino radiation-hydrodynamics simulations of core-collapse supernovae. We employ a full 3D two-moment scheme with the local M1 closure, three neutrino species, and 12 energy groups per species. With this, we follow the post-core-bounce evolution of the core of a nonrotating 27 - {M}ȯ progenitor in full unconstrained 3D and in octant symmetry for ≳380 ms. We find the development of an asymmetric runaway explosion in our unconstrained simulation. We test the resolution dependence of our results and, in agreement with previous work, find that low resolution artificially aids explosion and leads to an earlier runaway expansion of the shock. At low resolution, the octant and full 3D dynamics are qualitatively very similar, but at high resolution, only the full 3D simulation exhibits the onset of explosion.

  14. Effect of nonlinear three-dimensional optimized reconstruction algorithm filter on image quality and radiation dose: validation on phantoms.

    PubMed

    Bai, Mei; Chen, Jiuhong; Raupach, Rainer; Suess, Christoph; Tao, Ying; Peng, Mingchen

    2009-01-01

    A new technique called the nonlinear three-dimensional optimized reconstruction algorithm filter (3D ORA filter) is currently used to improve CT image quality and reduce radiation dose. This technical note describes the comparison of image noise, slice sensitivity profile (SSP), contrast-to-noise ratio, and modulation transfer function (MTF) on phantom images processed with and without the 3D ORA filter, and the effect of the 3D ORA filter on CT images at a reduced dose. For CT head scans the noise reduction was up to 54% with typical bone reconstruction algorithms (H70) and a 0.6 mm slice thickness; for liver CT scans the noise reduction was up to 30% with typical high-resolution reconstruction algorithms (B70) and a 0.6 mm slice thickness. MTF and SSP did not change significantly with the application of 3D ORA filtering (P > 0.05), whereas noise was reduced (P < 0.05). The low contrast detectability and MTF of images obtained at a reduced dose and filtered by the 3D ORA were equivalent to those of standard dose CT images; there was no significant difference in image noise of scans taken at a reduced dose, filtered using 3D ORA and standard dose CT (P > 0.05). The 3D ORA filter shows good potential for reducing image noise without affecting image quality attributes such as sharpness. By applying this approach, the same image quality can be achieved whilst gaining a marked dose reduction.

  15. Effect of nonlinear three-dimensional optimized reconstruction algorithm filter on image quality and radiation dose: Validation on phantoms

    SciTech Connect

    Bai Mei; Chen Jiuhong; Raupach, Rainer; Suess, Christoph; Tao Ying; Peng Mingchen

    2009-01-15

    A new technique called the nonlinear three-dimensional optimized reconstruction algorithm filter (3D ORA filter) is currently used to improve CT image quality and reduce radiation dose. This technical note describes the comparison of image noise, slice sensitivity profile (SSP), contrast-to-noise ratio, and modulation transfer function (MTF) on phantom images processed with and without the 3D ORA filter, and the effect of the 3D ORA filter on CT images at a reduced dose. For CT head scans the noise reduction was up to 54% with typical bone reconstruction algorithms (H70) and a 0.6 mm slice thickness; for liver CT scans the noise reduction was up to 30% with typical high-resolution reconstruction algorithms (B70) and a 0.6 mm slice thickness. MTF and SSP did not change significantly with the application of 3D ORA filtering (P>0.05), whereas noise was reduced (P<0.05). The low contrast detectability and MTF of images obtained at a reduced dose and filtered by the 3D ORA were equivalent to those of standard dose CT images; there was no significant difference in image noise of scans taken at a reduced dose, filtered using 3D ORA and standard dose CT (P>0.05). The 3D ORA filter shows good potential for reducing image noise without affecting image quality attributes such as sharpness. By applying this approach, the same image quality can be achieved whilst gaining a marked dose reduction.

  16. RADIATIVE AND MOMENTUM-BASED MECHANICAL ACTIVE GALACTIC NUCLEUS FEEDBACK IN A THREE-DIMENSIONAL GALAXY EVOLUTION CODE

    SciTech Connect

    Choi, Ena; Ostriker, Jeremiah P.; Naab, Thorsten; Johansson, Peter H.

    2012-08-01

    We study the growth of black holes (BHs) in galaxies using three-dimensional smoothed particle hydrodynamic simulations with new implementations of the momentum mechanical feedback, and restriction of accreted elements to those that are gravitationally bound to the BH. We also include the feedback from the X-ray radiation emitted by the BH, which heats the surrounding gas in the host galaxies, and adds radial momentum to the fluid. We perform simulations of isolated galaxies and merging galaxies and test various feedback models with the new treatment of the Bondi radius criterion. We find that overall the BH growth is similar to what has been obtained by earlier works using the Springel, Di Matteo, and Hernquist algorithms. However, the outflowing wind velocities and mechanical energy emitted by winds are considerably higher (v{sub w} {approx} 1000-3000 km s{sup -1}) compared to the standard thermal feedback model (v{sub w} {approx} 50-100 km s{sup -1}). While the thermal feedback model emits only 0.1% of BH released energy in winds, the momentum feedback model emits more than 30% of the total energy released by the BH in winds. In the momentum feedback model, the degree of fluctuation in both radiant and wind output is considerably larger than in standard treatments. We check that the new model of BH mass accretion agrees with analytic results for the standard Bondi problem.

  17. High-resolution three-dimensional visualization of the rat spinal cord microvasculature by synchrotron radiation micro-CT

    SciTech Connect

    Hu, Jianzhong; Cao, Yong; Wu, Tianding; Li, Dongzhe; Lu, Hongbin

    2014-10-15

    Purpose: Understanding the three-dimensional (3D) morphology of the spinal cord microvasculature has been limited by the lack of an effective high-resolution imaging technique. In this study, synchrotron radiation microcomputed tomography (SRµCT), a novel imaging technique based on absorption imaging, was evaluated with regard to the detection of the 3D morphology of the rat spinal cord microvasculature. Methods: Ten Sprague-Dawley rats were used in this ex vivo study. After contrast agent perfusion, their spinal cords were isolated and scanned using conventional x-rays, conventional micro-CT (CµCT), and SRµCT. Results: Based on contrast agent perfusion, the microvasculature of the rat spinal cord was clearly visualized for the first time ex vivo in 3D by means of SRµCT scanning. Compared to conventional imaging techniques, SRµCT achieved higher resolution 3D vascular imaging, with the smallest vessel that could be distinguished approximately 7.4 μm in diameter. Additionally, a 3D pseudocolored image of the spinal cord microvasculature was generated in a single session of SRµCT imaging, which was conducive to detailed observation of the vessel morphology. Conclusions: The results of this study indicated that SRµCT scanning could provide higher resolution images of the vascular network of the spinal cord. This modality also has the potential to serve as a powerful imaging tool for the investigation of morphology changes in the 3D angioarchitecture of the neurovasculature in preclinical research.

  18. Three-dimensional evaluation of the compression and recovery behavior in a flexible graphite sheet by synchrotron radiation microtomography

    SciTech Connect

    Kobayashi, M.; Toda, H.; Takeuchi, A.; Uesugi, K.; Suzuki, Y.

    2012-07-15

    The compression and unloading behavior of flexible graphite sheets was investigated using synchrotron radiation microtomography with 1 {mu}m voxel size. The recovery ratio of the flexible graphite sheet was measured accurately by in-situ observation. The three-dimensional strain distribution in the interior of the specimen was obtained using the microstructural tracking method. The inner strain distribution with micrometer scale indicated inhomogeneous deformation. The microstructural tracking analysis revealed that deformation units exist in the flexible graphite sheet. The units seem to deform, affecting the neighboring units with each other. The units had a similar size and shape with compacted exfoliated graphite worms that constitute the flexible graphite sheet. Microscopic deformations during compression and unloading are surely affected by the microstructure of the sheet. Highlights: Black-Right-Pointing-Pointer The compression and recovery behavior was investigated using microtomography. Black-Right-Pointing-Pointer The tracking analysis revealed that deformation units exist in the specimen. Black-Right-Pointing-Pointer Each unit deforms in relation to the neighboring unit.

  19. Three-dimensional Effects and Shortwave Cloud Radiative Forcing Associated with Shallow Cumuli Over Central North America

    SciTech Connect

    Berg, Larry K.; Kassianov, Evgueni I.; Long, Charles N.; Mills, Jr., David

    2009-09-30

    Shallow cumuli are ubiquitous over large areas of the globe, including both the interior of continents and the trade wind regions over the oceans. Measurements made at the Atmospheric Radiation Measurement (ARM) Climate Research Facility, located in central North America, provide a unique long-term data set that can be used to investigate the influence that these clouds have on the shortwave surface energy budget at a continental location. Using data collected for the summers of 2000 through 2007, inclusive, over 900 hours with fair-weather cumuli were identified using data from a Total Sky Imager, cloud-radar and lidar. Data from a suite of surface radiometers was used to determine the shortwave forcing. This analysis estimates the three-dimensional effects of shallow cumuli by examining the occurrences of both positive and negative shortwave forcing. We show that the average surface shortwave forcing is approximately -45.5 W m-2. When the data are adjusted to account for periods without shallow clouds, the shortwave forcing over the entire summer (defined as May through August) are reduced in magnitude, with forcings of -2.1 W m-2.

  20. Skin wound trauma, following high-dose radiation exposure, amplifies and prolongs skeletal tissue loss.

    PubMed

    Swift, Joshua M; Swift, Sibyl N; Smith, Joan T; Kiang, Juliann G; Allen, Matthew R

    2015-12-01

    The present study investigated the detrimental effects of non-lethal, high-dose (whole body) γ-irradiation on bone, and the impact that radiation combined with skin trauma (i.e. combined injury) has on long-term skeletal tissue health. Recovery of bone after an acute dose of radiation (RI; 8 Gy), skin wounding (15-20% of total body skin surface), or combined injury (RI+Wound; CI) was determined 3, 7, 30, and 120 days post-irradiation in female B6D2F1 mice and compared to non-irradiated mice (SHAM) at each time-point. CI mice demonstrated long-term (day 120) elevations in serum TRAP 5b (osteoclast number) and sclerostin (bone formation inhibitor), and suppression of osteocalcin levels through 30 days as compared to SHAM (p<0.05). Radiation-induced reductions in distal femur trabecular bone volume fraction and trabecular number through 120 days post-exposure were significantly greater than non-irradiated mice (p<0.05) and were exacerbated in CI mice by day 30 (p<0.05). Negative alterations in trabecular bone microarchitecture were coupled with extended reductions in cancellous bone formation rate in both RI and CI mice as compared to Sham (p<0.05). Increased osteoclast surface in CI animals was observed for 3 days after irradiation and remained elevated through 120 days (p<0.01). These results demonstrate a long-term, exacerbated response of bone to radiation when coupled with non-lethal wound trauma. Changes in cancellous bone after combined trauma were derived from extended reductions in osteoblast-driven bone formation and increases in osteoclast activity.

  1. Pilot Study on Image Quality and Radiation Dose of CT Colonography with Adaptive Iterative Dose Reduction Three-Dimensional

    PubMed Central

    Shen, Hesong; Liang, Dan; Luo, Mingyue; Duan, Chaijie; Cai, Wenli; Zhu, Shanshan; Qiu, Jianping; Li, Wenru

    2015-01-01

    Objective To investigate image quality and radiation dose of CT colonography (CTC) with adaptive iterative dose reduction three-dimensional (AIDR3D). Methods Ten segments of porcine colon phantom were collected, and 30 pedunculate polyps with diameters ranging from 1 to 15 mm were simulated on each segment. Image data were acquired with tube voltage of 120 kVp, and current doses of 10 mAs, 20 mAs, 30 mAs, 40 mAs, 50 mAs, respectively. CTC images were reconstructed using filtered back projection (FBP) and AIDR3D. Two radiologists blindly evaluated image quality. Quantitative evaluation of image quality included image noise, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR). Qualitative image quality was evaluated with a five-score scale. Radiation dose was calculated based on dose-length product. Ten volunteers were examined supine 50 mAs with FBP and prone 20 mAs with AIDR3D, and image qualities were assessed. Paired t test was performed for statistical analysis. Results For 20 mAs with AIDR3D and 50 mAs with FBP, image noise, SNRs and CNRs were (16.4 ± 1.6) HU vs. (16.8 ± 2.6) HU, 1.9 ± 0.2 vs. 1.9 ± 0.4, and 62.3 ± 6.8 vs. 62.0 ± 6.2, respectively; qualitative image quality scores were 4.1 and 4.3, respectively; their differences were all not statistically significant. Compared with 50 mAs with FBP, radiation dose (1.62 mSv) of 20 mAs with AIDR3D was decreased by 60.0%. There was no statistically significant difference in image noise, SNRs, CNRs and qualitative image quality scores between prone 20 mAs with AIDR3D and supine 50 mAs with FBP in 10 volunteers, the former reduced radiation dose by 61.1%. Conclusion Image quality of CTC using 20 mAs with AIDR3D could be comparable to standard 50 mAs with FBP, radiation dose of the former reduced by about 60.0% and was only 1.62 mSv. PMID:25635839

  2. High doses of gamma radiation suppress allergic effect induced by food lectin

    NASA Astrophysics Data System (ADS)

    Vaz, Antônio F. M.; Souza, Marthyna P.; Vieira, Leucio D.; Aguiar, Jaciana S.; Silva, Teresinha G.; Medeiros, Paloma L.; Melo, Ana M. M. A.; Silva-Lucca, Rosemeire A.; Santana, Lucimeire A.; Oliva, Maria L. V.; Perez, Katia R.; Cuccovia, Iolanda M.; Coelho, Luana C. B. B.; Correia, Maria T. S.

    2013-04-01

    One of the most promising areas for the development of functional foods lies in the development of effective methods to reduce or eliminate food allergenicity, but few reports have summarized information concerning the progress made with food irradiation. In this study, we investigated the relationship between allergenicity and molecular structure of a food allergen after gamma irradiation and evaluate the profile of the allergic response to irradiated allergens. Cramoll, a lectin isolated from a bean and used as a food allergen, was irradiated and the possible structural changes were accompanied by spectrofluorimetry, circular dichroism and microcalorimetry. Subsequently, sensitized animals subjected to intragastric administration of non-irradiated and irradiated Cramoll were treated for 7 days. Then, body weight, leukocytes, cytokine profiles and histological parameters were also determined. Cramoll showed complete inhibition of intrinsic activity after high radiation doses. Changes in fluorescence and CD spectra with a simultaneous collapse of the tertiary structure followed by a pronounced decrease of native secondary structure were observed after irradiation. After oral challenge, sensitized mice demonstrate an association between Cramoll intake, body weight loss, eosinophilia, lymphocytic infiltrate in the gut and Eotaxin secretion. Irradiation significantly reduces, according to the dose, the effects observed by non-irradiated food allergens. We confirm that high-dose radiation may render protein food allergens innocuous by irreversibly compromising their molecular structure.

  3. Comparison of three dimensional conformal radiation therapy, intensity modulated radiation therapy and volumetric modulated arc therapy for low radiation exposure of normal tissue in patients with prostate cancer.

    PubMed

    Cakir, Aydin; Akgun, Zuleyha; Fayda, Merdan; Agaoglu, Fulya

    2015-01-01

    Radiotherapy has an important role in the treatment of prostate cancer. Three-dimensional conformal radiation therapy (3D-CRT), intensity modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) techniques are all applied for this purpose. However, the risk of secondary radiation-induced bladder cancer is significantly elevated in irradiated patients compared surgery-only or watchful waiting groups. There are also reports of risk of secondary cancer with low doses to normal tissues. This study was designed to compare received volumes of low doses among 3D-CRT, IMRT and VMAT techniques for prostate patients. Ten prostate cancer patients were selected retrospectively for this planning study. Treatment plans were generated using 3D-CRT, IMRT and VMAT techniques. Conformity index (CI), homogenity index (HI), receiving 5 Gy of the volume (V5%), receiving 2 Gy of the volume (V2%), receiving 1 Gy of the volume (V1%) and monitor units (MUs) were compared. This study confirms that VMAT has slightly better CI while thev olume of low doses was higher. VMAT had lower MUs than IMRT. 3D-CRT had the lowest MU, CI and HI. If target coverage and normal tissue sparing are comparable between different treatment techniques, the risk of second malignancy should be a important factor in the selection of treatment.

  4. Formation of Overheated Regions and Truncated Disks around Black Holes: Three-dimensional General Relativistic Radiation-magnetohydrodynamics Simulations

    NASA Astrophysics Data System (ADS)

    Takahashi, Hiroyuki R.; Ohsuga, Ken; Kawashima, Tomohisa; Sekiguchi, Yuichiro

    2016-07-01

    Using three-dimensional general relativistic radiation-magnetohydrodynamics simulations of accretion flows around stellar mass black holes, we report that the relatively cold disk (≳ {10}7 {{K}}) is truncated near the black hole. Hot and less dense regions, of which the gas temperature is ≳ {10}9 {{K}} and more than 10 times higher than the radiation temperature (overheated regions), appear within the truncation radius. The overheated regions also appear above as well as below the disk, sandwiching the cold disk, leading to the effective Compton upscattering. The truncation radius is ˜ 30{r}{{g}} for \\dot{M}˜ {L}{{Edd}}/{c}2, where {r}{{g}},\\dot{M},{L}{Edd},c are the gravitational radius, mass accretion rate, Eddington luminosity, and light speed, respectively. Our results are consistent with observations of a very high state, whereby the truncated disk is thought to be embedded in the hot rarefied regions. The truncation radius shifts inward to ˜ 10{r}{{g}} with increasing mass accretion rate \\dot{M}˜ 100{L}{{Edd}}/{c}2, which is very close to an innermost stable circular orbit. This model corresponds to the slim disk state observed in ultraluminous X-ray sources. Although the overheated regions shrink if the Compton cooling effectively reduces the gas temperature, the sandwich structure does not disappear at the range of \\dot{M}≲ 100{L}{{Edd}}/{c}2. Our simulations also reveal that the gas temperature in the overheated regions depends on black hole spin, which would be due to efficient energy transport from black hole to disks through the Poynting flux, resulting in gas heating.

  5. Three-dimensional radiation-hydrodynamics calculations of the envelopes of young planets embedded in protoplanetary disks

    SciTech Connect

    D'Angelo, Gennaro; Bodenheimer, Peter E-mail: peter@ucolick.org

    2013-11-20

    We perform global three-dimensional (3D) radiation-hydrodynamics calculations of the envelopes surrounding young planetary cores of 5, 10, and 15 Earth masses, located in a protoplanetary disk at 5 and 10 AU from a solar-mass star. We apply a nested-grid technique to resolve the thermodynamics of the disk at the orbital-radius length scale and that of the envelope at the core-radius length scale. The gas is modeled as a solar mixture of molecular and atomic hydrogen, helium, and their ions. The equation of state accounts for both gas and radiation, and gas energy includes contributions from rotational and vibrational states of molecular hydrogen and from ionization of atomic species. Dust opacities are computed from first principles, applying the full Mie theory. One-dimensional (1D) calculations of planet formation are used to supplement the 3D calculations by providing energy deposition rates in the envelope due to solids accretion. We compare 1D and 3D envelopes and find that masses and gas accretion rates agree within factors of 2, and so do envelope temperatures. The trajectories of passive tracers are used to define the size of 3D envelopes, resulting in radii much smaller than the Hill radius and smaller than the Bondi radius. The moments of inertia and angular momentum of the envelopes are determined and the rotation rates are derived from the rigid-body approximation, resulting in slow bulk rotation. We find that the polar flattening is ≲ 0.05. The dynamics of the accretion flow are examined by tracking the motion of tracers that move into the envelope. The anisotropy of this flow is characterized in terms of both its origin and impact site at the envelope surface. Gas merges with the envelope preferentially at mid- to high latitudes.

  6. Three-Dimensional, Finite-Difference, Time-Domain Modeling of Local Volcano Infrasound Radiation Using GPU

    NASA Astrophysics Data System (ADS)

    Kim, K.; Lees, J. M.

    2013-12-01

    Since volcano infrasound is a direct measure of atmospheric pressure fluctuation near open-vent activity, it can provide important constraints on eruption source parameters including the volume of gas released and eruption velocity. Local infrasound data (<15 Km) have been used to quantify and characterize acoustic sources of volcanic eruptions since they are relatively less affected by atmospheric velocity structures in the near field. The interaction of volcano infrasound sources and complex topography near the volcanic edifice, however, has not been fully explored. Infrasound observations from world-wide volcanoes and two-dimensional numerical modeling of infrasound radiation in the vicinity of the crater suggest a strong distortion of the wavefield by local topography [Kim and Lees, GRL, 2011]. To get a complete picture of these effects, however, full three-dimensional modeling is required. We have developed a new, accelerated, 3D finite-difference time-domain program using GPU (Grpahic Processing Units) to simulate local infrasound propagation near volcanoes, while taking into account complex topography, local wind distortion, and atmospheric sound velocity structures. While CPU-based 3D FDTD method requires a prohibitive amount of computational resources, GPU-based algorithms significantly reduce the computational time of infrasound modeling, making parallel processing practical even on a desktop computer. In these simulations we provide a comprehensive solution of volcano infrasound radiation assuming different acoustic sources and real volcano topography. We illustrate the interaction of local vent topography and difference acoustic sources and how they combine to affect the infrasound wavefield. By removing topographic effects from local infrasound observation we can begin to quantitatively model acoustic sources and finally establish the partitioning of energy, at the vent, between the acoustic and seismic wavefields.

  7. Optically erasable samarium-doped fluorophosphate glasses for high-dose measurements in microbeam radiation therapy

    NASA Astrophysics Data System (ADS)

    Morrell, B.; Okada, G.; Vahedi, S.; Koughia, C.; Edgar, A.; Varoy, C.; Belev, G.; Wysokinski, T.; Chapman, D.; Sammynaiken, R.; Kasap, S. O.

    2014-02-01

    Previous work has demonstrated that fluorophosphate (FP) glasses doped with trivalent samarium (Sm3+) can be used as a dosimetric detector in microbeam radiation therapy (MRT) to measure high radiation doses and large dose variations with a resolution in the micrometer range. The present work addresses the use of intense optical radiation at 405 nm to erase the recorded dose information in Sm3+-doped FP glass plates and examines the underlying physics. We have evaluated both the conversion and optical erasure of Sm3+-doped FP glasses using synchrotron-generated high-dose x-rays at the Canadian Light Source. The Sm-ion valency conversion is accompanied by the appearance of x-ray induced optical absorbance due to the trapping of holes and electrons into phosphorus-oxygen hole (POHC) and electron (POEC) capture centers. Nearly complete Sm2+ to Sm3+ reconversion (erasure) may be achieved by intense optical illumination. Combined analysis of absorbance and electron spin resonance measurements indicates that the optical illumination causes partial disappearance of the POHC and the appearance of new POEC. The suggested model for the observed phenomena is based on the release of electrons during the Sm2+ to Sm3+ reconversion process, the capture of these electrons by POHC (and hence their disappearance), or by PO groups, with the appearance of new and/or additional POEC. Optical erasure may be used as a practical means to erase the recorded data and permits the reuse of these Sm-doped FP glasses in monitoring dose in MRT.

  8. High-Dose-Rate Intraoperative Radiation Therapy for Recurrent Head-and-Neck Cancer

    SciTech Connect

    Perry, David J.; Chan, Kelvin; Wolden, Suzanne; Zelefsky, Michael J.; Chiu, Johnny; Cohen, Gilad; Zaider, Marco; Kraus, Dennis; Shah, Jatin; Lee, Nancy

    2010-03-15

    Purpose: To report the use of high-dose-rate intraoperative radiation therapy (HDR-IORT) for recurrent head-and-neck cancer (HNC) at a single institution. Methods and Materials: Between July 1998 and February 2007, 34 patients with recurrent HNC received 38 HDR-IORT treatments using a Harrison-Anderson-Mick applicator with Iridium-192. A single fraction (median, 15 Gy; range, 10-20 Gy) was delivered intraoperatively after surgical resection to the region considered at risk for close or positive margins. In all patients, the target region was previously treated with external beam radiation therapy (median dose, 63 Gy; range, 24-74 Gy). The 1- and 2-year estimates for in-field local progression-free survival (LPFS), locoregional progression-free survival (LRPFS), distant metastases-free survival (DMFS), and overall survival (OS) were calculated. Results: With a median follow-up for surviving patients of 23 months (range, 6-54 months), 8 patients (24%) are alive and without evidence of disease. The 1- and 2-year LPFS rates are 66% and 56%, respectively, with 13 (34%) in-field recurrences. The 1- and 2-year DMFS rates are 81% and 62%, respectively, with 10 patients (29%) developing distant failure. The 1- and 2-year OS rates are 73% and 55%, respectively, with a median time to OS of 24 months. Severe complications included cellulitis (5 patients), fistula or wound complications (3 patients), osteoradionecrosis (1 patient), and radiation-induced trigeminal neuralgia (1 patient). Conclusions: HDR-IORT has shown encouraging local control outcomes in patients with recurrent HNC with acceptable rates of treatment-related morbidity. Longer follow-up with a larger cohort of patients is needed to fully assess the benefit of this procedure.

  9. Optically erasable samarium-doped fluorophosphate glasses for high-dose measurements in microbeam radiation therapy

    SciTech Connect

    Morrell, B.; Okada, G.; Vahedi, S.; Koughia, C. Kasap, S. O.; Edgar, A.; Varoy, C.; Belev, G.; Wysokinski, T.; Chapman, D.; Sammynaiken, R.

    2014-02-14

    Previous work has demonstrated that fluorophosphate (FP) glasses doped with trivalent samarium (Sm{sup 3+}) can be used as a dosimetric detector in microbeam radiation therapy (MRT) to measure high radiation doses and large dose variations with a resolution in the micrometer range. The present work addresses the use of intense optical radiation at 405 nm to erase the recorded dose information in Sm{sup 3+}-doped FP glass plates and examines the underlying physics. We have evaluated both the conversion and optical erasure of Sm{sup 3+}-doped FP glasses using synchrotron-generated high-dose x-rays at the Canadian Light Source. The Sm-ion valency conversion is accompanied by the appearance of x-ray induced optical absorbance due to the trapping of holes and electrons into phosphorus-oxygen hole (POHC) and electron (POEC) capture centers. Nearly complete Sm{sup 2+} to Sm{sup 3+} reconversion (erasure) may be achieved by intense optical illumination. Combined analysis of absorbance and electron spin resonance measurements indicates that the optical illumination causes partial disappearance of the POHC and the appearance of new POEC. The suggested model for the observed phenomena is based on the release of electrons during the Sm{sup 2+} to Sm{sup 3+} reconversion process, the capture of these electrons by POHC (and hence their disappearance), or by PO groups, with the appearance of new and/or additional POEC. Optical erasure may be used as a practical means to erase the recorded data and permits the reuse of these Sm-doped FP glasses in monitoring dose in MRT.

  10. Investigation of Three-Dimensional (3-D) Solar Radiative Transfer Effects Using A-Train Satellite Measurements

    NASA Astrophysics Data System (ADS)

    Ham, S.; Kato, S.; Barker, H.; Rose, F. G.

    2012-12-01

    Three-dimensional (3-D) radiative effects are examined for cloudy atmosphere obtained from A-train satellite measurements. Since CloudSat and Cloud Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) only provide two-dimensional (2-D) nadir profiles along the satellite track, Moderate Resolution Imaging Spectroradiometer (MODIS) spectral radiances are used to extend the 2-D cloud profiles to the cross track direction (Barker et al., 2011). Then one-dimensional (1-D) and 3-D simulations are performed to get (SW) broad band (BB) flux and heating rate profile for constructed 3-D cloud field. In the simulation, correlated k-distribution model is employed to obtain rapid estimation of gaseous optical depths for 70 solar spectral bands. The difference between 1-D and 3-D results are interpreted as 3-D solar effects, and analyzed for different cloud types and solar zenith angle. In addition, modeled top-of-atmosphere (TOA) irradiances by the 1-D and 3-D models are compared to Clouds and the Earth's Radiant Energy System (CERES)-derived TOA irradiances. The preliminary results show that 3-D cloud absorption is larger than 1-D calculation, and thus 3-D heating rate is larger than 1-D heating rate for cloud layer. On the other hand, 3-D downward flux at surface is smaller than 1-D flux. Reference Barker, H. W., M. P. Jerg, T. Wehr, S. Kato, D. P. Donovan, and R. J. Hogan, 2011, A 3D cloud-construction algorithm for the EarthCARE mission, Q. J. R. Meteorol. Soc., 137, 1042-1058.

  11. THREE-DIMENSIONAL RADIATIVE TRANSFER CALCULATIONS OF RADIATION FEEDBACK FROM MASSIVE BLACK HOLES: OUTFLOW OF MASS FROM THE DUSTY 'TORUS'

    SciTech Connect

    Roth, Nathaniel; Kasen, Daniel; Quataert, Eliot; Hopkins, Philip F.

    2012-11-01

    Observational and theoretical arguments suggest that the momentum carried in mass outflows from active galactic nuclei (AGNs) can reach several times L/c, corresponding to outflow rates of hundreds of solar masses per year. Radiation pressure on resonant absorption lines alone may not be sufficient to provide this momentum deposition, and the transfer of reprocessed IR radiation in dusty nuclear gas has been postulated to provide the extra enhancement. The efficacy of this mechanism, however, will be sensitive to multi-dimensional effects such as the tendency for the reprocessed radiation to preferentially escape along sightlines of lower column density. We use Monte Carlo radiative transfer calculations to determine the radiation force on dusty gas residing within approximately 30 parsecs from an accreting supermassive black hole. We calculate the net rate of momentum deposition in the surrounding gas and estimate the mass-loss rate in the resulting outflow as a function of solid angle for different black hole luminosities, sightline-averaged column densities, clumping parameters, and opening angles of the dusty gas. We find that these dust-driven winds carry momentum fluxes of 1-5 times L/c and correspond to mass-loss rates of 10-100 M {sub Sun} per year for a 10{sup 8} M {sub Sun} black hole radiating at or near its Eddington limit. These results help to explain the origin of high velocity molecular and atomic outflows in local ultraluminous infrared galaxies and can inform numerical simulations of galaxy evolution including AGN feedback.

  12. Identifying cell and molecular stress after radiation in a three-dimensional (3-D) model of oral mucositis

    SciTech Connect

    Lambros, Maria Polikandritou; Parsa, Cyrus; Mulamalla, HariChandana; Orlando, Robert; Lau, Bernard; Huang, Ying; Pon, Doreen; Chow, Moses

    2011-02-04

    Research highlights: {yields} We irradiated a 3-D human oral cell culture of keratinocytes and fibroblasts with 12 and 2 Gy. {yields} 6 h after irradiation the histopathology and apoptosis of the 3-D culture were evaluated. Microarrays were used to assess the gene expression in the irradiated 3-D tissue. {yields} 12 Gy induced significant histopathologic changes and cellular apoptosis. {yields} 12 Gy significantly affected genes of the NF-kB pathway, inflammatory cytokines and DAMPs. -- Abstract: Mucositis is a debilitating adverse effect of chemotherapy and radiation treatment. It is important to develop a simple and reliable in vitro model, which can routinely be used to screen new drugs for prevention and treatment of mucositis. Furthermore, identifying cell and molecular stresses especially in the initiation phase of mucositis in this model will help towards this end. We evaluated a three-dimensional (3-D) human oral cell culture that consisted of oral keratinocytes and fibroblasts as a model of oral mucositis. The 3-D cell culture model was irradiated with 12 or 2 Gy. Six hours after the irradiation we evaluated microscopic sections of the cell culture for evidence of morphologic changes including apoptosis. We used microarrays to compare the expression of several genes from the irradiated tissue with identical genes from tissue that was not irradiated. We found that irradiation with 12 Gy induced significant histopathologic effects including cellular apoptosis. Irradiation significantly affected the expression of several genes of the NF-kB pathway and several inflammatory cytokines, such as IL-1B, 1L-8, NF-kB1, and FOS compared to tissue that was not irradiated. We identified significant upregulation of several genes that belong to damage-associated molecular patterns (DAMPs) such as HMB1, S100A13, SA10014, and SA10016 in the 3-D tissues that received 12 Gy but not in tissues that received 2 Gy. In conclusion, this model quantifies radiation damage and this

  13. Vector theory of laser radiation scattering in an integrated optical waveguide with three-dimensional irregularities in the presence of noise

    SciTech Connect

    Egorov, Alexander A

    2004-08-31

    The vector theory of laser radiation scattering in an integrated optical waveguide with three-dimensional irregularities in the presence of noise is developed. The solution of the electrodynamic problem of laser radiation scattering in an irregular waveguide is obtained by the mode coupling technique using the perturbation theory. An approximate solution of the inhomogeneous three-dimensional wave equation is obtained by the method of Green's functions. The analytic formulas are derived for the radiation fields of propagating and evanescent modes. A physical interpretation is given for the obtained results. The role of noise as an independent depolarising factor (in addition to the classical one) during scattering of light is pointed out. (integrated optical waveguides and devices)

  14. Safety and Tolerability of SBRT after High-Dose External Beam Radiation to the Lung

    PubMed Central

    Owen, Dawn; Olivier, Kenneth R.; Song, Limin; Mayo, Charles S.; Miller, Robert C.; Nelson, Kathryn; Bauer, Heather; Brown, Paul D.; Park, Sean S.; Ma, Daniel J.; Garces, Yolanda I.

    2015-01-01

    Purpose: Stereotactic body radiotherapy (SBRT) is commonly used to treat unresectable lung nodules. Given its relative safety and effective local control, SBRT has also been used to treat recurrent lung nodules after high-dose external beam radiation (EBRT) to the lung. The toxicity of such treatment is unknown. Methods and Materials: Between 2006 and 2012, 18 subjects at the Mayo Clinic with 27 recurrent lung nodules were treated with SBRT after receiving EBRT to the lung. Median local control, overall survival, and progression-free survival (PFS) were described. Acute toxicity and late toxicity (defined as toxicity ≥ and >90 days, respectively) were reported and graded as per standardized CTCAE 4.0 criteria. Results: The median age of patients treated was 68 years. Fifteen patients had recurrent lung cancer as their primary histology. Twelve patients received ≥60 Gy of conventional EBRT prior to SBRT. SBRT dose and fractionation varied; the most common prescriptions were 48 Gy/4, 54 Gy/3, and 50 Gy/5 fractions. Only four patients had SBRT planning target volumes (PTVs) that overlapped more than 50% of their prior EBRT PTV. Two patients developed local recurrence following SBRT. With a median follow up of 21.2 months, median SBRT-specific overall survival and PFS were 21.7 and 12.3 months, respectively. No grade ≥3 acute or late toxicities were noted. Conclusion: Stereotactic body radiotherapy may be a good salvage option for select patients with recurrent lung nodules following definitive EBRT to the chest. Toxicity is minimal and local control is excellent. PMID:25642416

  15. Genetic compensation of high dose radiation-induced damage in an anhydrobiotic insect

    NASA Astrophysics Data System (ADS)

    Gusev, Oleg; Nakahara, Yuichi; Sakashita, Tetsuya; Kikawada, Takahiro; Okuda, Takashi

    Anhydrobiotic larvae of African chironomid Polypedilum vanderplanki are known to show an extremely high tolerance against a range of stresses. The tolerance against various extreme environments exhibited by that insect might be due to being almost completely desiccated replacing water with trehalose, a state where little or no chemical reactions occur. From 2005 dried larvae of this insect are being used in a number of space experiments, both inside and outside of ISS as a model organism for estimation the limits of higher organisms' resistance to space environment stresses and long-term storage of the alive anhydrobiotic organisms during continues spaceflight. We have shown previously that both hydrated and dried larvae of Polypedilum vanderplanki have very higher tolerance against both highand low-linear energy transfer (LET), surviving after 7000Gy irradiation. It was suggested that the larvae would have effective DNA-reparation system in addition to artificial protection provided by glass-stage without water. In the present study we conducted analysis of stress-related gene expression in the larvae after 70-2000 Gy irradiations. Both DNA damage level and activity of DNA-reparation, anti-apoptotic and protein-damage related genes were analyzed. Direct visualization of DNA damage in the larvae fat body cells using Comet Assay showed that fragmented by radiation DNA is re-arranged within 76-98 hours after exposure. We found that massive overexpression of hsp and anti-oxidant genes occur in larvae entering anhydrobiosis , and provides refolding of proteins after rehydration. In the irradiated larvae overexpression of DNA-reparation enzymes anti-apoptotic genes was confirmed, suggesting that survival after high-dose irradiation is a result of combination of highly effective blocking of entering the apoptosis after severe DNA damage and DNA reparation.

  16. Monte Carlo Study of Radiation Dose Enhancement by Gadolinium in Megavoltage and High Dose Rate Radiotherapy

    PubMed Central

    Zhang, Daniel G.; Feygelman, Vladimir; Moros, Eduardo G.; Latifi, Kujtim; Zhang, Geoffrey G.

    2014-01-01

    MRI is often used in tumor localization for radiotherapy treatment planning, with gadolinium (Gd)-containing materials often introduced as a contrast agent. Motexafin gadolinium is a novel radiosensitizer currently being studied in clinical trials. The nanoparticle technologies can target tumors with high concentration of high-Z materials. This Monte Carlo study is the first detailed quantitative investigation of high-Z material Gd-induced dose enhancement in megavoltage external beam photon therapy. BEAMnrc, a radiotherapy Monte Carlo simulation package, was used to calculate dose enhancement as a function of Gd concentration. Published phase space files for the TrueBeam flattening filter free (FFF) and conventional flattened 6MV photon beams were used. High dose rate (HDR) brachytherapy with Ir-192 source was also investigated as a reference. The energy spectra difference caused a dose enhancement difference between the two beams. Since the Ir-192 photons have lower energy yet, the photoelectric effect in the presence of Gd leads to even higher dose enhancement in HDR. At depth of 1.8 cm, the percent mean dose enhancement for the FFF beam was 0.38±0.12, 1.39±0.21, 2.51±0.34, 3.59±0.26, and 4.59±0.34 for Gd concentrations of 1, 5, 10, 15, and 20 mg/mL, respectively. The corresponding values for the flattened beam were 0.09±0.14, 0.50±0.28, 1.19±0.29, 1.68±0.39, and 2.34±0.24. For Ir-192 with direct contact, the enhanced were 0.50±0.14, 2.79±0.17, 5.49±0.12, 8.19±0.14, and 10.80±0.13. Gd-containing materials used in MRI as contrast agents can also potentially serve as radiosensitizers in radiotherapy. This study demonstrates that Gd can be used to enhance radiation dose in target volumes not only in HDR brachytherapy, but also in 6 MV FFF external beam radiotherapy, but higher than the currently used clinical concentration (>5 mg/mL) would be needed. PMID:25275550

  17. Monte Carlo study of radiation dose enhancement by gadolinium in megavoltage and high dose rate radiotherapy.

    PubMed

    Zhang, Daniel G; Feygelman, Vladimir; Moros, Eduardo G; Latifi, Kujtim; Zhang, Geoffrey G

    2014-01-01

    MRI is often used in tumor localization for radiotherapy treatment planning, with gadolinium (Gd)-containing materials often introduced as a contrast agent. Motexafin gadolinium is a novel radiosensitizer currently being studied in clinical trials. The nanoparticle technologies can target tumors with high concentration of high-Z materials. This Monte Carlo study is the first detailed quantitative investigation of high-Z material Gd-induced dose enhancement in megavoltage external beam photon therapy. BEAMnrc, a radiotherapy Monte Carlo simulation package, was used to calculate dose enhancement as a function of Gd concentration. Published phase space files for the TrueBeam flattening filter free (FFF) and conventional flattened 6MV photon beams were used. High dose rate (HDR) brachytherapy with Ir-192 source was also investigated as a reference. The energy spectra difference caused a dose enhancement difference between the two beams. Since the Ir-192 photons have lower energy yet, the photoelectric effect in the presence of Gd leads to even higher dose enhancement in HDR. At depth of 1.8 cm, the percent mean dose enhancement for the FFF beam was 0.38±0.12, 1.39±0.21, 2.51±0.34, 3.59±0.26, and 4.59±0.34 for Gd concentrations of 1, 5, 10, 15, and 20 mg/mL, respectively. The corresponding values for the flattened beam were 0.09±0.14, 0.50±0.28, 1.19±0.29, 1.68±0.39, and 2.34±0.24. For Ir-192 with direct contact, the enhanced were 0.50±0.14, 2.79±0.17, 5.49±0.12, 8.19±0.14, and 10.80±0.13. Gd-containing materials used in MRI as contrast agents can also potentially serve as radiosensitizers in radiotherapy. This study demonstrates that Gd can be used to enhance radiation dose in target volumes not only in HDR brachytherapy, but also in 6 MV FFF external beam radiotherapy, but higher than the currently used clinical concentration (>5 mg/mL) would be needed.

  18. Mixed convection radiative flow of three dimensional Maxwell fluid over an inclined stretching sheet in presence of thermophoresis and convective condition

    SciTech Connect

    Ashraf, M. Bilal; Hayat, T.; Shehzad, S. A.; Alsaedi, A.

    2015-02-15

    Three dimensional radiative flow of Maxwell fluid over an inclined stretching surface with convective boundary condition is investigated. Heat and mass transfer analysis is taken into account with thermophoresis effects. Similarity transformations are utilized to reduce the partial differential equations into ordinary differential equations. Series solutions of velocity, temperature and concentration are developed. Influence of different parameters Biot number, therrmophoretic parameter, Deborah number, ratio parameter, inclined stretching angle, radiation parameter, mixed convection parameter and concentration buoyancy parameter on the non-dimensional velocity components, temperature and concentration are plotted and discussed in detail. Physical quantities of interests are tabulated and examined.

  19. Mechanism of action for anti-radiation vaccine in reducing the biological impact of high-dose gamma irradiation

    NASA Astrophysics Data System (ADS)

    Maliev, Vladislav; Popov, Dmitri; Jones, Jeffrey A.; Casey, Rachael C.

    Ionizing radiation is a major health risk of long-term space travel, the biological consequences of which include genetic and oxidative damage. In this study, we propose an original mechanism by which high doses of ionizing radiation induce acute toxicity. We identified biological components that appear in the lymphatic vessels shortly after high-dose gamma irradiation. These radiation-induced toxins, which we have named specific radiation determinants (SRD), were generated in the irradiated tissues and then circulated throughout the body via the lymph circulation and bloodstream. Depending on the type of SRD elicited, different syndromes of acute radiation sickness (ARS) were expressed. The SRDs were developed into a vaccine used to confer active immunity against acute radiation toxicity in immunologically naïve animals. Animals that were pretreated with SRDs exhibited resistance to lethal doses of gamma radiation, as measured by increased survival times and survival rates. In comparison, untreated animals that were exposed to similar large doses of gamma radiation developed acute radiation sickness and died within days. This phenomenon was observed in a number of mammalian species. Initial analysis of the biochemical characteristics indicated that the SRDs were large molecular weight (200-250 kDa) molecules that were comprised of a mixture of protein, lipid, carbohydrate, and mineral. Further analysis is required to further identify the SRD molecules and the biological mechanism by which they mediate the toxicity associated with acute radiation sickness. By doing so, we may develop an effective specific immunoprophylaxis as a countermeasure against the acute effects of ionizing radiation.

  20. Three-dimensional modeling of genome macroarchitecture on the basis of its structural changes after the action of radiation

    NASA Astrophysics Data System (ADS)

    Aleksandrov, I. D.; Aleksandrova, M. V.; Zaikin, N. S.; Koren'kov, V. V.; Pervushova, O. V.; Stepanenko, V. A.

    2006-12-01

    At present, after 120 years of theoretical and experimental studies, the problem of the genome macroarchitecture as the highest level of interphase chromosome organization in the nucleus of somatic cells is still open. The problem of spatial organization of interphase chromosomes in the haploid nucleus of germ cells has never been studied. The three-dimensional modeling of spatial organization of part of the haploid genome (the second chromosome) in Drosophila melanogaster mature sperms is performed using mathematical methods and the methods of visualization of macromolecular biostructures. The frequency and arrangement of inversion breaks for 72 structural vg mutants were used as genetic markers under the assumption that both ends of each inversion are brought together and form loops of an appropriate size. For taking into account the spatial proximity and visualization of loop structures of the chromosome, modern methods of three-dimensional modeling with application of splines, Open GL library, Delphi, and Gmax were used. According to the model developed, the whole second chromosome in the nucleus of mature sperms is probably arranged in the form of the megarosette-loop structure, which can be assumed to be the fundamental ordered form of the genome macroarchitecture in haploid germs of higher organisms.

  1. High-dose selenium for the mitigation of radiation injury: a pilot study in a rat model.

    PubMed

    Sieber, Fritz; Muir, Sarah A; Cohen, Eric P; North, Paula E; Fish, Brian L; Irving, Amy A; Mäder, Marylou; Moulder, John E

    2009-03-01

    The purpose of this study was to evaluate in an animal model the safety and efficacy of dietary supplementation with high doses of selenium for the mitigation of the type of radiation injury that might be sustained during a nuclear accident or an act of radiological terrorism. Age-matched male rats were exposed to 10 Gy (single dose) of total-body irradiation (TBI) followed by a syngeneic bone marrow transplant, then randomized to standard drinking water or drinking water supplemented with sodium selenite or seleno-l-methionine. At 21 weeks after TBI, most rats on standard drinking water had severe renal failure with a mean blood urea nitrogen (BUN) level of 124 +/- 29 mg/dl (geometric mean +/- SE) whereas rats on selenium-supplemented drinking water (100 microg/day) had a mean BUN level of 67 +/- 12 mg/dl. The mitigating effect of selenium was confirmed by histopathological analyses. None of the animals on high-dose selenium showed signs of selenium toxicity. Our results suggest that dietary supplementation with high-dose selenium may provide a safe, effective and practical way to mitigate radiation injury to kidneys. PMID:19267564

  2. Three-dimensional MHD boundary layer flow due to an axisymmetric shrinking sheet with radiation, viscous dissipation and heat source/sink

    NASA Astrophysics Data System (ADS)

    Madhu, M.; Balaswamy, B.; Kishan, N.

    2016-05-01

    An analysis is made to study a three dimensional MHD boundary layer flow and heat transfer due to a porous axisymmetric shrinking sheet. The governing partial differential equations of momentum and energy are transformed into self similar non-linear ordinary differential equations by using the suitable similarity transformations. These equations are, then solved by using the variational finite element method. The flow phenomena is characterised by the magnetic parameter M, suction parameter S, porosity parameter Kp, heat source/sink parameter Q, Prandtl number Pr, Eckert number Ec and radiation parameter Rd. The numerical results of the velocity and temperature profiles are obtained and displayed graphically.

  3. The Effectiveness of Intensity Modulated Radiation Therapy versus Three-Dimensional Radiation Therapy in Prostate Cancer: A Meta-Analysis of the Literatures

    PubMed Central

    Zheng, Tianying; Shi, Huashan; Liu, Yang; Feng, Shijian; Hao, Meiqin; Ye, Lei; Wu, Xueqian; Yang, Cheng

    2016-01-01

    Background and Purpose Intensity modulated radiation therapy (IMRT) can deliver higher doses with less damage of healthy tissues compared with three-dimensional radiation therapy (3DCRT). However, for the scenarios with better clinical outcomes for IMRT than 3DCRT in prostate cancer, the results remain ambiguous. We performed a meta-analysis to assess whether IMRT can provide better clinical outcomes in comparison with 3DCRT in patients diagnosed with prostate cancer. Materials and Methods We conducted a meta-analysis of 23 studies (n = 9556) comparing the clinical outcomes, including gastrointestinal (GI) toxicity, genitourinary (GU) toxicity, biochemical controland overall survival (OS). Results IMRT was significantly associated with decreased 2–4 grade acute GI toxicity [risk ratio (RR) = 0.59 (95% confidence interval (CI), 0.44, 0.78)], late GI toxicity [RR = 0.54, 95%CI (0.38, 0.78)], late rectal bleeding [RR = 0.48, 95%CI (0.27, 0.85)], and achieved better biochemical control[RR = 1.17, 95%CI (1.08, 1.27)] in comparison with 3DCRT. IMRT and 3DCRT remain the same in regard of grade 2–4 acute rectal toxicity [RR = 1.03, 95%CI (0.45, 2.36)], late GU toxicity [RR = 1.03, 95%CI (0.82, 1.30)] and overall survival [RR = 1.07, 95%CI (0.96, 1.19)], while IMRT slightly increased the morbidity of grade 2–4 acute GU toxicity [RR = 1.08, 95%CI (1.00, 1.17)]. Conclusions Although some bias cannot be ignored, IMRT appears to be a better choice for the treatment of prostate cancer when compared with 3DCRT. PMID:27171271

  4. Thermal and scatter effects on the radiation sensitivity of well chambers used for high dose rate Ir-192 calibrations.

    PubMed

    Podgorsak, M B; DeWerd, L A; Thomadsen, B R; Paliwal, B R

    1992-01-01

    High dose rate (HDR) iridium sources must be calibrated regularly because of the short half-life of Ir-192. High dose rate sources can now be calibrated using a new well-type chamber that allows easy, reproducible source calibrations. The chamber includes a styrofoam insulator that surrounds the source in the well. A study of the radiation sensitivity of the well chamber exposed to an HDR Ir-192 source at two different activities (300 and 230 GBq) revealed that the sensitivity of the chamber varies by as much as 1.1% as the chamber is moved toward a scattering surface. Second, with the styrofoam insulator removed, the air temperature within the ion collecting volume increased during exposure, causing a gradual decrease in chamber sensitivity of 0.15% in 30 min. This temperature increase was caused by heat transfer from radiation emitted by the Ir-192 source, and diminished as the source decayed. However, with the styrofoam insulator around the central aluminum tube in the well, the source cannot heat the collecting volume and thus thermal equilibrium between the ion collecting volume and its environment is maintained throughout an exposure. The radiation sensitivity of the commercial well chamber was found to be constant for exposure times of 30 min.

  5. Effect of conjoint administration of tamoxifen and high-dose radiation on the development of mammary carcinoma

    SciTech Connect

    Kantorowitz, D.A. ); Thompson, H.J. ); Furmanski, P. )

    1993-04-30

    Tamoxifen is currently advocated for post-menopausal breast cancer patients receiving definitive irradiation after limited surgery. The purpose of this study was to assess in an experimental model for breast cancer whether the efficacy of irradiation is altered by conjoint administration of tamoxifen. To this end, rats with small tumors induced by 1-methyl-1-nitrosourea (MNU) were treated with tamoxifen, radiation, or a combination of the two modalities. Female Sprague Dawley rats were injected i.p. with 50 mg MNU/kg body weight at 50 days of age. At 64 days post carcinogen, the majority of the rats had at least one palpable mammary tumor. At that time radiation with or without tamoxifen treatment was initiated and given 5 days per week for 5 weeks. Radiation dose was 4500 cGy delivered as 25, 180 cGy fractions. Tamoxifen, 500 mg/kg body weight, was administered subcutaneously each day during the irradiation interval. The study was terminated 28 weeks after carcinogen treatment. High dose radiation alone induced a reduction in the size of existing tumors, but resulted in a significant increase in the number of tumors that were detected. Treatment with tamoxifen alone also caused a reduction in tumor volume, but had no effect on final incidence or number of mammary tumors. Combined modality treatment resulted in a significant reduction in the volume of existing tumors and suppressed the enhanced occurrence of additional tumors observed when only radiation alone was administered. The findings of this study indicate that in the context of fractionated, high dose radiation treatment of established mammary cancers, tamoxifen may reduce the likelihood of subsequent tumor development and by so doing prove a helpful simultaneous conjoint adjuvant treatment to post-operative irradiation. 35 refs., 1 fig., 2 tabs.

  6. Quantum-mechanical calculation of three-dimensional atom-diatom collisions in the presence of intense laser radiation

    NASA Technical Reports Server (NTRS)

    Devries, P. L.; George, T. F.

    1979-01-01

    A formalism is presented for describing the collision of fluorine with the hydrogen molecule in the presence of intense radiation. For a laser frequency on the order of the spin-orbit splitting of fluorine, the interaction of the molecular system with the radiation occurs at relatively long range where, for this system, the electric dipole is vanishingly small. Hence the interaction occurs due to the magnetic dipole coupling. Even so, at low collision energies a substantial enhancement of the quenching cross section is found for a radiation intensity of 10 to the 11th W/sq cm.

  7. Mechanism of Action for Anti-Radiation Vaccine in Reducing the Biological Impact of High-Dose Irradiation

    NASA Technical Reports Server (NTRS)

    Maliev, Vladislav; Popov, Dmitri; Jones, Jeffrey A.; Casey, Rachael C.

    2006-01-01

    Ionizing radiation is a major health risk of long-term space travel, the biological consequences of which include genetic and oxidative damage. In this study, we propose an original mechanism by which high doses of ionizing radiation induce acute toxicity. We identified biological components that appear in the lymphatic vessels shortly after gamma irradiation. These radiation-induced toxins, which we have named specific radiation determinants (SRD), were generated in the irradiated tissues and then collected and circulated throughout the body via the lymph circulation and bloodstream. Depending on the type of SRD elicited, different syndromes of acute radiation sickness (ARS) were expressed. The SRDs were developed into a vaccine used to confer active immunity against acute radiation toxicity in immunologically naive animals. Animals that were pretreated with SRDs exhibited resistance to lethal doses of gamma radiation, as measured by increased survival times and survival rates. In comparison, untreated animals that were exposed to similar large doses of gamma radiation developed acute radiation sickness and died within days. This phenomenon was observed in a number of mammalian species. We partially analyzed the biochemical characteristics of the SRDs. The SRDs were large molecular weight (200-250 kDa) molecules that were comprised of a mixture of protein, lipid, carbohydrate, and mineral. Further analysis is required to further identify the SRD molecules and the biological mechanism by which the mediate the toxicity associated with acute radiation sickness. By doing so, we may develop an effective specific immunoprophylaxis as a countermeasure against the acute effects of ionizing radiation.

  8. Mechanism of Action for Anti-radiation Vaccine in Reducing the Biological Impact of High-dose Gamma Irradiation

    NASA Technical Reports Server (NTRS)

    Maliev, Vladislav; Popov, Dmitri; Jones, Jeffrey A.; Casey, Rachael C.

    2007-01-01

    Ionizing radiation is a major health risk of long-term space travel, the biological consequences of which include genetic and oxidative damage. In this study, we propose an original mechanism by which high doses of ionizing radiation induce acute toxicity. We identified biological components that appear in the lymphatic vessels shortly after gamma irradiation. These radiation-induced toxins, which we have named specific radiation determinants (SRD), were generated in the irradiated tissues and then collected and circulated throughout the body via the lymph circulation and bloodstream. Depending on the type of SRD elicited, different syndromes of acute radiation sickness (ARS) were expressed. The SRDs were developed into a vaccine used to confer active immunity against acute radiation toxicity in immunologically naive animals. Animals that were pretreated with SRDs exhibited resistance to lethal doses of gamma radiation, as measured by increased survival times and survival rates. In comparison, untreated animals that were exposed to similar large doses of gamma radiation developed acute radiation sickness and died within days. This phenomenon was observed in a number of mammalian species. Initial analysis of the biochemical characteristics indicated that the SRDs were large molecular weight (200-250 kDa) molecules that were comprised of a mixture of protein, lipid, carbohydrate, and mineral. Further analysis is required to further identify the SRD molecules and the biological mechanism by which the mediate the toxicity associated with acute radiation sickness. By doing so, we may develop an effective specific immunoprophylaxis as a countermeasure against the acute effects of ionizing radiation.

  9. Impulse response solution to the three-dimensional vector radiative transfer equation in atmosphere-ocean systems. II. The hybrid matrix operator--Monte Carlo method.

    PubMed

    Zhai, Peng-Wang; Kattawar, George W; Yang, Ping

    2008-03-10

    A hybrid method is developed to solve the vector radiative transfer equation (VRTE) in a three-dimensional atmosphere-ocean system (AOS). The system is divided into three parts: the atmosphere, the dielectric interface, and the ocean. The Monte Carlo method is employed to calculate the impulse response functions (Green functions) for the atmosphere and ocean. The impulse response function of the dielectric interface is calculated by the Fresnel formulas. The matrix operator method is then used to couple these impulse response functions to obtain the vector radiation field for the AOS. The primary advantage of this hybrid method is that it solves the VRTE efficiently in an AOS with different dielectric interfaces while keeping the same atmospheric and oceanic conditions. For the first time, we present the downward radiance field in an ocean with a sinusoidal ocean wave.

  10. Three-dimensional photovoltaics

    NASA Astrophysics Data System (ADS)

    Myers, Bryan; Bernardi, Marco; Grossman, Jeffrey C.

    2010-02-01

    The concept of three-dimensional (3D) photovoltaics is explored computationally using a genetic algorithm to optimize the energy production in a day for arbitrarily shaped 3D solar cells confined to a given area footprint and total volume. Our simulations demonstrate that the performance of 3D photovoltaic structures scales linearly with height, leading to volumetric energy conversion, and provides power fairly evenly throughout the day. Furthermore, we show that optimal 3D structures are not simple box-like shapes, and that design attributes such as reflectivity could be optimized using three-dimensionality.

  11. Three-dimensional photovoltaics

    NASA Astrophysics Data System (ADS)

    Myers, Bryan; Bernardi, Marco; Grossman, Jeffrey C.

    2010-03-01

    The concept of three-dimensional (3D) photovoltaics is explored computationally using a genetic algorithm to optimize the energy production in a day for arbitrarily shaped 3D solar cells confined to a given area footprint and total volume. Our simulations demonstrate that the performance of 3D photovoltaic structures scales linearly with height, leading to volumetric energy conversion, and provides power fairly evenly throughout the day. Furthermore, we show that optimal 3D shapes are not simple box-like shapes, and that design attributes such as reflectivity can be optimized in new ways using three-dimensionality.

  12. Using synchrotron radiation inline phase-contrast imaging computed tomography to visualize three-dimensional printed hybrid constructs for cartilage tissue engineering.

    PubMed

    Olubamiji, Adeola D; Izadifar, Zohreh; Zhu, Ning; Chang, Tuanjie; Chen, Xiongbiao; Eames, B Frank

    2016-05-01

    Synchrotron radiation inline phase-contrast imaging combined with computed tomography (SR-inline-PCI-CT) offers great potential for non-invasive characterization and three-dimensional visualization of fine features in weakly absorbing materials and tissues. For cartilage tissue engineering, the biomaterials and any associated cartilage extracellular matrix (ECM) that is secreted over time are difficult to image using conventional absorption-based imaging techniques. For example, three-dimensional printed polycaprolactone (PCL)/alginate/cell hybrid constructs have low, but different, refractive indices and thicknesses. This paper presents a study on the optimization and utilization of inline-PCI-CT for visualizing the components of three-dimensional printed PCL/alginate/cell hybrid constructs for cartilage tissue engineering. First, histological analysis using Alcian blue staining and immunofluorescent staining assessed the secretion of sulfated glycosaminoglycan (GAGs) and collagen type II (Col2) in the cell-laden hybrid constructs over time. Second, optimization of inline PCI-CT was performed by investigating three sample-to-detector distances (SDD): 0.25, 1 and 3 m. Then, the optimal SDD was utilized to visualize structural changes in the constructs over a 42-day culture period. The results showed that there was progressive secretion of cartilage-specific ECM by ATDC5 cells in the hybrid constructs over time. An SDD of 3 m provided edge-enhancement fringes that enabled simultaneous visualization of all components of hybrid constructs in aqueous solution. Structural changes that might reflect formation of ECM also were evident in SR-inline-PCI-CT images. Summarily, SR-inline-PCI-CT images captured at the optimized SDD enables visualization of the different components in hybrid cartilage constructs over a 42-day culture period. PMID:27140161

  13. The susceptibility of TaOx-based memristors to high dose rate ionizing radiation and total ionizing dose

    DOE PAGES

    McLain, Michael Lee; Sheridan, Timothy J.; Hjalmarson, Harold Paul; Mickel, Patrick R.; Hanson, Donald J.; McDonald, Joseph K.; Hughart, David Russell; Marinella, Matthew J.

    2014-11-11

    This paper investigates the effects of high dose rate ionizing radiation and total ionizing dose (TID) on tantalum oxide (TaOx) memristors. Transient data were obtained during the pulsed exposures for dose rates ranging from approximately 5.0 ×107 rad(Si)/s to 4.7 ×108 rad(Si)/s and for pulse widths ranging from 50 ns to 50 μs. The cumulative dose in these tests did not appear to impact the observed dose rate response. Static dose rate upset tests were also performed at a dose rate of ~3.0 ×108 rad(Si)/s. This is the first dose rate study on any type of memristive memory technology. Inmore » addition to assessing the tolerance of TaOx memristors to high dose rate ionizing radiation, we also evaluated their susceptibility to TID. The data indicate that it is possible for the devices to switch from a high resistance off-state to a low resistance on-state in both dose rate and TID environments. The observed radiation-induced switching is dependent on the irradiation conditions and bias configuration. Furthermore, the dose rate or ionizing dose level at which a device switches resistance states varies from device to device; the enhanced susceptibility observed in some devices is still under investigation. As a result, numerical simulations are used to qualitatively capture the observed transient radiation response and provide insight into the physics of the induced current/voltages.« less

  14. Three-dimensional inhomogeneous rain fields: implications for the distribution of intensity and polarization of the microwave thermal radiation.

    NASA Astrophysics Data System (ADS)

    Ilyushin, Yaroslaw; Kutuza, Boris

    Observations and mapping of the upwelling thermal radiation of the Earth is the very promising remote sensing technique for the global monitoring of the weather and precipitations. For reliable interpretation of the observation data, numerical model of the microwave radiative transfer in the precipitating atmosphere is necessary. In the present work, numerical simulations of thermal microwave radiation in the rain have been performed at three wavelengths (3, 8 and 22 mm). Radiative properties of the rain have been simulated using public accessible T-matrix codes (Mishchenko, Moroz) for non-spherical particles of fixed orientation and realistic raindrop size distributions (Marshall-Palmer) within the range of rain intensity 1-100 mm/h. Thermal radiation of infinite flat slab medium and isolated rain cell of kilometer size has been simulated with finite difference scheme for the vectorial radiative transfer equation (VRTE) in dichroic scattering medium. Principal role of cell structure of the rain field in the formation of angular and spatial distribution of the intensity and polarization of the upwelling thermal radiation has been established. Possible approaches to interpretation of satellite data are also discussed. It is necessary that spatial resolution of microwave radiometers be less than rain cell size. At the present time the resolution is approximately 15 km. It can be considerably improved, for example by two-dimensional synthetic aperture millimeter-wave radiometric interferometer for measuring full-component Stokes vector of emission from hydrometeors. The estimates show that in millimeter band it is possible to develop such equipment with spatial resolution of the order of 1-2 km, which is significantly less than the size of rain cell, with sensitivity 0.3-0.5 K. Under this condition the second Stokes parameter may by successfully measured and may be used for investigation of precipitation regions. Y-shaped phased array antenna is the most promising to

  15. Comparative MicroRNA Expression Patterns in Fibroblasts after Low and High Doses of Low-LET Radiation Exposure

    NASA Technical Reports Server (NTRS)

    Maes, Olivier C.; Xu, Suying; Hada, Megumi; Wu, Honglu; Wang, Eugenia

    2007-01-01

    Exposure to ionizing radiation causes DNA damage to cells, and provokes a plethora of cellular responses controlled by unique gene-directed signaling pathways. MicroRNAs (miRNAs) are small (22-nucleotide), non-coding RNAs which functionally silence gene expression by either degrading the messages or inhibiting translation. Here we investigate radiation-dependent changes in these negative regulators by comparing the expression patterns of all 462 known human miRNAs in fibroblasts, after exposure to low (0.1 Gy) or high (2 Gy) doses of X-rays at 30 min, 2, 6 and 24 hrs post-treatment. The expression patterns of microRNAs after low and high doses of radiation show a similar qualitative down-regulation trend at early (0.5 hr) and late (24 hr) time points, with a quantitatively steeper slope following the 2 Gy exposures. Interestingly, an interruption of this downward trend is observed after the 2 Gy exposure, i.e. a significant up-regulation of microRNAs at 2 hrs, then reverting to the downward trend by 6 hrs; this interruption at the intermediate time point was not observed with the 0.1 Gy exposure. At the early time point (0.5 hr), candidate gene targets of selected down-regulated microRNAs, common to both 0.1 and 2 Gy exposures, were those functioning in chromatin remodeling. Candidate target genes of unique up-regulated microRNAs seen at a 2 hr intermediate time point, after the 2 Gy exposure only, are those involved in cell death signaling. Finally, putative target genes of down-regulated microRNAs seen at the late (24 hr) time point after either doses of radiation are those involved in the up-regulation of DNA repair, cell signaling and homeostasis. Thus we hypothesize that after radiation exposure, microRNAs acting as hub negative regulators for unique signaling pathways needed to be down-regulated so as to de-repress their target genes for the proper cellular responses, including DNA repair and cell maintenance. The unique microRNAs up-regulated at 2 hr after 2

  16. Three-dimensional, two-species magnetohydrodynamic studies of the early time behaviors of the Combined Release and Radiation Effects Satellite G2 barium release

    SciTech Connect

    Xie, Lianghai Li, Lei; Wang, Jingdong; Zhang, Yiteng

    2014-04-15

    We present a three-dimensional, two-species (Ba{sup +} and H{sup +}) MHD model to study the early time behaviors of a barium release at about 1 R{sub E} like Combined Release and Radiation Effects Satellite G2, with emphasis placed on the three-dimensional evolution of the barium cloud and its effects on the ambient plasma environment. We find that the perturbations caused by the cloud are the combined results of the initial injection, the radial expansion, and the diamagnetic effect and propagate as fast MHD waves in the magnetosphere. In return, the transverse expansion and the cross-B motion of barium ions are constrained by the magnetic force, which lead to a field-aligned striation of ions and the decoupling of these ions from the neutrals. Our simulation shows the formation and collapse of the diamagnetic cavity in the barium cloud. The estimated time scale for the cavity evolution might be much shorter if photoionization time scale and field aligned expansion of barium ions are considered. In addition, our two species MHD simulation also finds the snowplow effect resulting from the momentum coupling between barium ions and background H{sup +}, which creates density hole and bumps in the background H{sup +} when barium ions expanding along the magnetic field lines.

  17. High-dose radiation therapy alone by moderate hypofractionation for patients with thoracic esophageal squamous cell carcinoma.

    PubMed

    Oh, Dongryul; Noh, Jae Myoung; Nam, Heerim; Lee, Hyebin; Kim, Tae Gyu; Ahn, Yong Chan

    2016-08-01

    We conducted retrospective analyses to investigate the clinical outcome of thoracic esophageal cancer patients who were treated with high-dose radiation therapy (RT) alone by moderate hypofractionation due to medical unfitness or refusal to receive either surgery or chemo-radiotherapy.Between May 2003 and April 2013, 70 patients were treated with high-dose RT alone with curative aim. The planned total RT dose was 60 Gy in daily 3.0 Gy per fraction. We evaluated the survival outcome, toxicities, and prognostic factors affecting patients' survival.At the time of analysis, 32 patients experienced disease progression. The 2-year overall survival (OS), cancer-specific survival (CSS) and local control (LC) rates were 52.1%, 57.8%, and 68.2%, respectively. Among them, 25 patients had superficial (cT1a-b) esophageal cancers, and the 2-year OS, CSS, and LC rates were 80.0%, 87.3%, and 81.6%, respectively. Multivariate analysis revealed that cT disease (P < 0.001) and tumor location (P = 0.022) were the significant factors for OS. The incidence of grade 3 or higher toxicities were 9.9%, including grade 3 esophagitis (2 patients, 2.8%) and grade 4 or 5 trachea-esophageal fistula (5 patients, 7.1%).High-dose RT alone by moderate hypofractionation had led to reasonable clinical outcomes at acceptable toxicity risk in thoracic esophageal cancer patients who are medically unfit or refuse surgery or chemotherapy, especially for the patients having superficial lesion. PMID:27537591

  18. Octave-wide photonic band gap in three-dimensional plasmonic Bragg structures and limitations of radiative coupling

    PubMed Central

    Taubert, Richard; Dregely, Daniel; Stroucken, Tineke; Christ, Andre; Giessen, Harald

    2012-01-01

    Radiative coupling between oscillators is one of the most fundamental subjects of research in optics, where particularly a Bragg-type arrangement is of interest and has already been applied to atoms and excitons in quantum wells. Here we explore this arrangement in a plasmonic structure. We observe the emergence of an octave-wide photonic band gap in the optical regime. Compared with atomic or excitonic systems, the coupling efficiency of the particle plasmons utilized here is several orders of magnitude larger and widely tunable by changing the size and geometry of the plasmonic nanowires. We are thus able to explore the regime where the coupling distance is even limited by the large radiative decay rate of the oscillators. This Bragg-stacked coupling scheme will open a new route for future plasmonic applications such as far-field coupling to quantum emitters without quenching, plasmonic cavity structures and plasmonic distributed gain schemes for spasers. PMID:22353721

  19. Development and validation of a black carbon mixing state resolved three-dimensional model: Aging processes and radiative impact

    SciTech Connect

    Matsui, H.; Koike, Makoto; Kondo, Yutaka; Moteki, N.; Fast, Jerome D.; Zaveri, Rahul A.

    2013-03-16

    : A new two-dimensional aerosol bin scheme, which resolves both aerosol size and black carbon (BC) mixing state for BC aging processes (e.g., condensation and coagulation), has been developed and implemented into the WRF-chem model (MS-resolved WRF-chem). The mixing state of BC simulated by this model is compared with direct measurements over the East Asian region in spring 2009. Model simulations generally reproduce the observed features of the BC mixing state, such as the size-dependent number fractions of BC-containing and BC-free particles and the coating thickness of BC-containing particles. Sensitivity simulations show that the condensation process is dominant for the growth of thinly coated BC particles, while the coagulation process is necessary to produce thickly coated BC particles. Off-line optical and radiative calculations assuming an average mixing state for each size bin show that the domain- and period-averaged absorption coefficient and heating rate by aerosols are overestimated by 30 – 40% in the boundary layer compared with a benchmark simulation with the detailed treatment of mixing state. The absolute value of aerosol radiative forcing is also overestimated (10%, 3 W m-2) at the surface. However, these overestimations are reduced considerably when all the parameters (including mass and number concentration) are calculated with the simple treatment of mixing state. This is because the overestimation of radiative parameters due to higher absorption efficiency (compared with the benchmark simulation) is largely canceled by the underestimation of BC concentrations due to efficient wet removal processes. The overall errors in radiative forcing can be much smaller because of this cancellation but for the wrong reasons.

  20. Meridian is a three-dimensional network from bio-electromagnetic radiation interference: an interference hypothesis of meridian.

    PubMed

    Han, Jinxiang

    2012-03-01

    An electromagnetic radiation field within a biological organism is characterized by non-local interference. The interfering beams form a unitary tridimensional network with beams of varying intensity, also called striae, which are distributed on the organism surface. These striae are equivalent to semi-reflectors. The striae carry bio-information of corresponding organs and, thus, integrate all tissues, and organs of the organism. The longitudinal striae are classified as channels, while the transverse striae are collaterals. The acupoints are seen as the points where electromagnetic interfering striae intersect or converge. This hypothesis builds a foundation to understand the traditional Chinese medicine, including acupuncture, from the perspective of scientific knowledge.

  1. Validation of three-dimensional radiative transfer in coastal-ocean water systems as modeled by DIRSIG

    NASA Astrophysics Data System (ADS)

    Speir, Jacqueline Amy

    The radiative transfer equation (RTE) is a mathematical description of radiative gains and losses experienced by a propagating electromagnetic wave in a participating medium. Except for an isotropic lossless vacuum, all other volumes have the potential to scatter, absorb and emit radiant energy. Of these possible events, the global scattering term is the greatest obstacle between a radiative transfer problem and its solution. Historically, the RTE has been solved using a host of analytical approximations and numerical methods. Typical solution models exploit plane-parallel assumptions where it is assumed that optical properties may vary vertically with depth, but have an infinite horizontal extent. For more complicated scenarios that include pronounced 3D variability, a Monte Carlo statistical approach to the radiative transfer solution is often utilized. This statistical approach has been integrated within the Digital Imaging and Remote Sensing Image Generation (DIRSIG) model in the form of photon mapping. Photon mapping provides a probabilistic solution to the in-scattered radiance problem, by employing a two-pass technique that first populates a photon map based on a Monte Carlo solution to the global scattering term, and then later uses this map to reconstruct the in-scattered radiance distribution during a traditional raytracing pass. As with any computational solution, the actual implementation of the technique requires assumptions, simplifications and integration within a cohesive rendering model. Moreover, the realistic simulation of any environment requires several other radiometric solutions that are not directly related to the photon mapped in-scattered radiance. This research attempts to validate raytraced and photon mapped contributions to sensor reaching radiance that can be expected in typical littoral environments, including boundary interface, medium and submerged or floating object effects. This is accomplished by comparing DIRSIG modeled results

  2. Dyed polyvinyl chloride films for use as high-dose routine dosimeters in radiation processing

    NASA Astrophysics Data System (ADS)

    Mai, Hoang Hoa; Duong, Nguyen Dinh; Kojima, Takuji

    2004-04-01

    Characteristics of the polyvinyl chloride (PVC) films containing 0.11 wt% of malachite green oxalate or 6GX-setoglausine and about 100 μm in thickness were studied for use as routine dosimeters in radiation processing. These films show basically color bleaching under irradiation with 60Co γ-rays in a dose range of 5-50 kGy. The sensitivity of the dosimeters and the linearity of dose-response curves are improved by adding 2.5% of chloral hydrate [CCl 3CH(OH) 2] and 0.15% hydroquinone [HOC 6H 4OH]. These additions extend the minimum dose limit to 1 kGy covering dosimetry requirements of the quality assurance in radiation processing of food and healthcare products. The dose responses of both dyed PVC films at irradiation temperatures from 20°C to 35°C are constant relative to those at 25°C, and the temperature coefficients for irradiation temperatures from 35°C to 55°C were estimated to be (0.43±0.01)%/°C. The dosimeter characteristics are stable within 1% at 25°C before and 60 days after the end of irradiation.

  3. Coupling sky images with three-dimensional radiative transfer models: a new method to estimate cloud optical depth

    NASA Astrophysics Data System (ADS)

    Mejia, F. A.; Kurtz, B.; Murray, K.; Hinkelman, L. M.; Sengupta, M.; Xie, Y.; Kleissl, J.

    2015-10-01

    A method for retrieving cloud optical depth (τc) using a ground-based sky imager (USI) is presented. The Radiance Red-Blue Ratio (RRBR) method is motivated from the analysis of simulated images of various τc produced by a 3-D Radiative Transfer Model (3DRTM). From these images the basic parameters affecting the radiance and RBR of a pixel are identified as the solar zenith angle (θ0), τc, solar pixel angle/scattering angle (ϑs), and pixel zenith angle/view angle (ϑz). The effects of these parameters are described and the functions for radiance, Iλ(τc, θ0, ϑs, ϑz) and the red-blue ratio, RBR(τc, θ0, ϑs, ϑz) are retrieved from the 3DRTM results. RBR, which is commonly used for cloud detection in sky images, provides non-unique solutions for τc, where RBR increases with τc up to about τc = 1 (depending on other parameters) and then decreases. Therefore, the RRBR algorithm uses the measured Iλmeas(ϑs, ϑz), in addition to RBRmeas(ϑs, ϑz) to obtain a unique solution for τc. The RRBR method is applied to images taken by a USI at the Oklahoma Atmospheric Radiation Measurement program (ARM) site over the course of 220 days and validated against measurements from a microwave radiometer (MWR); output from the Min method for overcast skies, and τc retrieved by Beer's law from direct normal irradiance (DNI) measurements. A τc RMSE of 5.6 between the Min method and the USI are observed. The MWR and USI have an RMSE of 2.3 which is well within the uncertainty of the MWR. An RMSE of 0.95 between the USI and DNI retrieved τc is observed. The procedure developed here provides a foundation to test and develop other cloud detection algorithms.

  4. The landsat scale break in stratocumulus as a three-dimensional radiative transfer effect: Implications for cloud remote sensing

    SciTech Connect

    Davis, A.; Marshak, A.; Cahalan, R.; Wiscombe, W.

    1997-01-15

    Several studies have uncovered a break in the scaling properties of Landsat cloud scenes at nonabsorbing wavelengths. For scales greater than 200-400 m, the wavenumber spectrum is approximately power law in k{sup {minus}5/3}, but from there down to the smallest observable scales (50-100 m) follows another k{sup {minus}{beta}} law with {beta} > 3. This implies very smooth radiance fields. The authors reexamine the empirical evidence for this scale break and explain it using fractal cloud models. Monte Carlo simulations, and a Green function approach to multiple scattering theory. In particular, the authors define the {open_quotes}radiative smoothing scale{close_quotes} and relate it to the characteristic scale of horizontal photon transport. The scale break was originally thought to occur at a scale commensurate with either the geometrical thickness {Delta}{sub z} of the cloud, or with the {open_quotes}transport{close_quotes} mean free path l{sub t} = [(1 {minus} g){sigma}]{sup {minus}1}, which incorporates the effect of forward scattering ({sigma} is extinction and g the asymmetry factor of the phase function). The smoothing scale is found to be approximately {radical}l{sub 1}{Delta}{sub z} at cloud top; this is the prediction of diffusion theory which applies when (1 {minus} g){tau} = {Delta}{sub z}/l{sub 1} {ge} 1 ({tau} is optical thickness). Since the scale break is a tangible effect of net horizontal radiative fluxes excited by the fluctuations of {tau}, the smoothing scale sets an absolute lower bound on the range where one can neglect these fluxes and use plane-parallel theory locally, even for stratiform clouds. In particular, this constrains the retrieval of cloud properties from remotely sensed data. Finally, the characterization of horizontal photon transport suggest a new lidar technique for joint measurements of optical and geometrical thicknesses at about 0.5-km resolution. 53 refs., 14 figs., 1 tab.

  5. Three-dimensional, Time-Resolved, Intrafraction Motion Monitoring Throughout Stereotactic Liver Radiation Therapy on a Conventional Linear Accelerator

    SciTech Connect

    Worm, Esben S.; Høyer, Morten; Fledelius, Walter; Poulsen, Per R.

    2013-05-01

    Purpose: To investigate the time-resolved 3-dimensional (3D) internal motion throughout stereotactic body radiation therapy (SBRT) of tumors in the liver using standard x-ray imagers of a conventional linear accelerator. Methods and Materials: Ten patients with implanted gold markers received 11 treatment courses of 3-fraction SBRT in a stereotactic body-frame on a conventional linear accelerator. Two pretreatment and 1 posttreatment cone-beam computed tomography (CBCT) scans were acquired during each fraction. The CBCT projection images were used to estimate the internal 3D marker motion during CBCT acquisition with 11-Hz resolution by a monoscopic probability-based method. Throughout the treatment delivery by conformal or volumetric modulated arc fields, simultaneous MV portal imaging (8 Hz) and orthogonal kV imaging (5 Hz) were applied to determine the 3D marker motion using either MV/kV triangulation or the monoscopic method when marker segmentation was unachievable in either MV or kV images. The accuracy of monoscopic motion estimation was quantified by also applying monoscopic estimation as a test for all treatments during which MV/kV triangulation was possible. Results: Root-mean-square deviations between monoscopic estimations and triangulations were less than 1.0 mm. The mean 3D intrafraction and intrafield motion ranges during liver SBRT were 17.6 mm (range, 5.6-39.5 mm) and 11.3 mm (2.1-35.5mm), respectively. The risk of large intrafraction baseline shifts correlated with intrafield respiratory motion range. The mean 3D intrafractional marker displacement relative to the first CBCT was 3.4 mm (range, 0.7-14.5 mm). The 3D displacements exceeded 8.8 mm 10% of the time. Conclusions: Highly detailed time-resolved internal 3D motion was determined throughout liver SBRT using standard imaging equipment. Considerable intrafraction motion was observed. The demonstrated methods provide a widely available approach for motion monitoring that, combined with motion

  6. Comparison of Acute and Late Toxicities for Three Modern High-Dose Radiation Treatment Techniques for Localized Prostate Cancer

    SciTech Connect

    Mohammed, Nasiruddin; Kestin, Larry; Ghilezan, Mihai; Krauss, Daniel; Vicini, Frank; Brabbins, Donald; Gustafson, Gary; Ye Hong; Martinez, Alavaro

    2012-01-01

    Purpose: We compared acute and late genitourinary (GU) and gastrointestinal (GI) toxicities in prostate cancer patients treated with three different high-dose radiation techniques. Methods and Materials: A total of 1,903 patients with localized prostate cancer were treated with definitive RT at William Beaumont Hospital from 1992 to 2006: 22% with brachytherapy alone (BT), 55% with image-guided external beam (EB-IGRT), and 23% external beam with high-dose-rate brachytherapy boost (EBRT+HDR). Median dose with BT was 120 Gy for LDR and 38 Gy for HDR (9.5 Gy Multiplication-Sign 4). Median dose with EB-IGRT was 75.6 Gy (PTV) to prostate with or without seminal vesicles. For EBRT+HDR, the pelvis was treated to 46 Gy with an additional 19 Gy (9.5 Gy Multiplication-Sign 2) delivered via HDR. GI and GU toxicity was evaluated utilizing the NCI-CTC criteria (v.3.0). Median follow-up was 4.8 years. Results: The incidences of any acute {>=} Grade 2 GI or GU toxicities were 35%, 49%, and 55% for BT, EB-IGRT, and EBRT+HDR (p < 0.001). Any late GU toxicities {>=} Grade 2 were present in 22%, 21%, and 28% for BT, EB-IGRT, and EBRT+HDR (p = 0.01), respectively. Patients receiving EBRT+HDR had a higher incidence of urethral stricture and retention, whereas dysuria was most common in patients receiving BT. Any Grade {>=}2 late GI toxicities were 2%, 20%, and 9% for BT, EB-IGRT, and EBRT+HDR (p < 0.001). Differences were most pronounced for rectal bleeding, with 3-year rates of 0.9%, 20%, and 6% (p < 0.001) for BT, EB-IGRT, and EBRT+HDR respectively. Conclusions: Each of the three modern high-dose radiation techniques for localized prostate cancer offers a different toxicity profile. These data can help patients and physicians to make informed decisions regarding radiotherapy for prostate andenocarcinoma.

  7. Alteration of the serum N-glycome of mice locally exposed to high doses of ionizing radiation.

    PubMed

    Chaze, Thibault; Slomianny, Marie-Christine; Milliat, Fabien; Tarlet, Georges; Lefebvre-Darroman, Tony; Gourmelon, Patrick; Bey, Eric; Benderitter, Marc; Michalski, Jean-Claude; Guipaud, Olivier

    2013-02-01

    Exposure of the skin to ionizing radiation leads to characteristic reactions that will often turn into a pathophysiological process called the cutaneous radiation syndrome. The study of this disorder is crucial to finding diagnostic and prognostic bioindicators of local radiation exposure or radiation effects. It is known that irradiation alters the serum proteome content and potentially post-translationally modifies serum proteins. In this study, we investigated whether localized irradiation of the skin alters the serum glycome. Two-dimensional differential in-gel electrophoresis of serum proteins from a man and from mice exposed to ionizing radiation showed that potential post-translational modification changes occurred following irradiation. Using a large-scale quantitative mass-spectrometry-based glycomic approach, we performed a global analysis of glycan structures of serum proteins from non-irradiated and locally irradiated mice exposed to high doses of γ-rays (20, 40, and 80 Gy). Non-supervised descriptive statistical analyses (principal component analysis) using quantitative glycan structure data allowed us to discriminate between uninjured/slightly injured animals and animals that developed severe lesions. Decisional statistics showed that several glycan families were down-regulated whereas others increased, and that particular structures were statistically significantly changed in the serum of locally irradiated mice. The observed increases in multiantennary N-glycans and in outer branch fucosylation and sialylation were associated with the up-regulation of genes involved in glycosylation in the liver, which is the main producer of serum proteins, and with an increase in the key proinflammatory serum cytokines IL-1β, IL-6, and TNFα, which can regulate the expression of glycosylation genes. Our results suggest for the first time a role of serum protein glycosylation in response to irradiation. These protein-associated glycan structure changes might

  8. Three-dimensional imaging of human hippocampal tissue using synchrotron radiation- and grating-based micro computed tomography

    NASA Astrophysics Data System (ADS)

    Hieber, Simone E.; Khimchenko, Anna; Kelly, Christopher; Mariani, Luigi; Thalmann, Peter; Schulz, Georg; Schmitz, Rüdiger; Greving, Imke; Dominietto, Marco; Müller, Bert

    2014-09-01

    Hippocampal sclerosis is a common cause of epilepsy, whereby a neuronal cell loss of more than 50% cells is characteristic. If medication fails the best possible treatment is the extraction of the diseased organ. To analyze the microanatomy of the diseased tissue we scanned a human hippocampus extracted from an epilepsy patient. After the identification of degenerated tissue using magnetic resonance imaging the specimen was reduced in size to fit into a cylindrical container with a diameter of 6 mm. Using synchrotron radiation and grating interferometry we acquired micro computed tomography datasets of the specimen. The present study was one of the first successful phase tomography measurements at the imaging beamline P05 (operated by HZG at the PETRA III storage ring, DESY, Hamburg, Germany). Ring and streak artefacts were reduced by enhanced flat-field corrections, combined wavelet-Fourier filters and bilateral filtering. We improved the flat-field correction by the consideration of the correlation between the projections and the flat-field images. In the present study, the correlation that was based on mean squared differences and evaluated on manually determined reference regions leads to the best artefact reduction. A preliminary segmentation of the abnormal tissue reveals that a clinically relevant study requires the development of even more sophisticated artifact reduction tools or a phase contrast measurement of higher quality.

  9. Ex vivo cultures of glioblastoma in three-dimensional hydrogel maintain the original tumor growth behavior and are suitable for preclinical drug and radiation sensitivity screening

    SciTech Connect

    Jiguet Jiglaire, Carine; Baeza-Kallee, Nathalie; Denicolaï, Emilie; Barets, Doriane; Metellus, Philippe; and others

    2014-02-15

    Identification of new drugs and predicting drug response are major challenges in oncology, especially for brain tumors, because total surgical resection is difficult and radiation therapy or chemotherapy is often ineffective. With the aim of developing a culture system close to in vivo conditions for testing new drugs, we characterized an ex vivo three-dimensional culture system based on a hyaluronic acid-rich hydrogel and compared it with classical two-dimensional culture conditions. U87-MG glioblastoma cells and seven primary cell cultures of human glioblastomas were subjected to radiation therapy and chemotherapy drugs. It appears that 3D hydrogel preserves the original cancer growth behavior and enables assessment of the sensitivity of malignant gliomas to radiation and drugs with regard to inter-tumoral heterogeneity of therapeutic response. It could be used for preclinical assessment of new therapies. - Highlights: • We have compared primary glioblastoma cell culture in a 2D versus 3D-matrix system. • In 3D morphology, organization and markers better recapitulate the original tumor. • 3D-matrix culture might represent a relevant system for more accurate drug screening.

  10. Laser-guided direct writing for three-dimensional tissue engineering: Analysis and application of radiation forces

    NASA Astrophysics Data System (ADS)

    Nahmias, Yaakov Koby

    Tissue Engineering aims for the creation of functional tissues or organs using a combination of biomaterials and living cells. Artificial tissues can be implanted in patients to restore tissue function that was lost due to trauma, disease, or genetic disorder. Tissue equivalents may also be used to screen the effects of drugs and toxins, reducing the use of animals in research. One of the principle limitations to the size of engineered tissue is oxygen and nutrient transport. Lacking their own vascular bed, cells embedded in the engineered tissue will consume all available oxygen within hours while out branching blood vessels will take days to vascularize the implanted tissue. Establishing capillaries within the tissue prior to implantation can potentially eliminate this limitation. One approach to establishing capillaries within the tissue is to directly write endothelial cells with micrometer accuracy as it is being built. The patterned endothelial cells will then self-assemble into vascular structures within the engineering tissue. The cell patterning technique known as laser-guided direct writing can confine multiple cells in a laser beam and deposit them as a steady stream on any non-absorbing surface with micrometer scale accuracy. By applying the generalized Lorenz-Mie theory for light scattering on laser-guided direct writing we were able to accurately predict the behavior of with various cells and particles in the focused laser. In addition, two dimensionless parameters were identified for general radiation-force based system design. Using laser-guided direct writing we were able to direct the assembly of endothelial vascular structures with micrometer accuracy in two and three dimensions. The patterned vascular structures provided the backbone for subsequent in vitro liver morphogenesis. Our studies show that hepatocytes migrate toward and adhere to endothelial vascular structures in response to endothelial-secreted hepatocyte growth factor (HGF). Our

  11. Upregulated epidermal growth factor receptor expression following near-infrared irradiation simulating solar radiation in a three-dimensional reconstructed human corneal epithelial tissue culture model

    PubMed Central

    Tanaka, Yohei; Nakayama, Jun

    2016-01-01

    Background and objective Humans are increasingly exposed to near-infrared (NIR) radiation from both natural (eg, solar) and artificial (eg, electrical appliances) sources. Although the biological effects of sun and ultraviolet (UV) exposure have been extensively investigated, the biological effect of NIR radiation is still unclear. We previously reported that NIR as well as UV induces photoaging and standard UV-blocking materials, such as sunglasses, do not sufficiently block NIR. The objective of this study was to investigate changes in gene expression in three-dimensional reconstructed corneal epithelial tissue culture exposed to broad-spectrum NIR irradiation to simulate solar NIR radiation that reaches human tissues. Materials and methods DNA microarray and quantitative real-time polymerase chain reaction analysis were used to assess gene expression levels in a three-dimensional reconstructed corneal epithelial model composed of normal human corneal epithelial cells exposed to water-filtered broad-spectrum NIR irradiation with a contact cooling (20°C). The water-filter allowed 1,000–1,800 nm wavelengths and excluded 1,400–1,500 nm wavelengths. Results A DNA microarray with >62,000 different probes showed 25 and 150 genes that were up- or downregulated by at least fourfold and twofold, respectively, after NIR irradiation. In particular, epidermal growth factor receptor (EGFR) was upregulated by 19.4-fold relative to control cells. Quantitative real-time polymerase chain reaction analysis revealed that two variants of EGFR in human corneal epithelial tissue were also significantly upregulated after five rounds of 10 J/cm2 irradiation (P<0.05). Conclusion We found that NIR irradiation induced the upregulated expression of EGFR in human corneal cells. Since over half of the solar energy reaching the Earth is in the NIR region, which cannot be adequately blocked by eyewear and thus can induce eye damage with intensive or long-term exposure, protection from both

  12. Pulmonary Artery Invasion, High-Dose Radiation, and Overall Survival in Patients With Non-Small Cell Lung Cancer

    SciTech Connect

    Han, Cheng-Bo; Wang, Wei-Li; Quint, Leslie; Xue, Jian-Xin; Matuszak, Martha; Ten Haken, Randall; Kong, Feng-Ming

    2014-06-01

    Purpose: To investigate whether high-dose radiation to the pulmonary artery (PA) affects overall survival (OS) in patients with non-small cell lung cancer (NSCLC). Methods and Materials: Patients with medically inoperable/unresectable NSCLC treated with definitive radiation therapy in prospective studies were eligible for this study. Pulmonary artery involvement was defined on the basis of pretreatment chest CT and positron emission tomography/CT fusion. Pulmonary artery was contoured according to the Radiation Therapy Oncology Group protocol 1106 atlas, and dose-volume histograms were generated. Results: A total of 100 patients with a minimum follow-up of 1 year for surviving patients were enrolled: 82.0% underwent concurrent chemoradiation therapy. Radiation dose ranged from 60 to 85.5 Gy in 30-37 fractions. Patients with PA invasion of grade ≤2, 3, 4, and 5 had 1-year OS and median survival of 67% and 25.4 months (95% confidence interval [CI] 15.7-35.1), 62% and 22.2 months (95% CI 5.8-38.6), 90% and 35.8 months (95% CI 28.4-43.2), and 50% and 7.0 months, respectively (P=.601). Two of the 4 patients with grade 5 PA invasion died suddenly from massive hemorrhage at 3 and 4.5 months after completion of radiation therapy. Maximum and mean doses to PA were not significantly associated with OS. The V45, V50, V55, and V60 of PA were correlated significantly with a worse OS (P<.05). Patients with V45 >70% or V60 >37% had significantly worse OS (13.3 vs 37.9 months, P<.001, and 13.8 vs 37.9 months, P=.04, respectively). Conclusions: Grade 5 PA invasion and PA volume receiving more than 45-60 Gy may be associated with inferior OS in patients with advanced NSCLC treated with concurrent chemoradiation.

  13. Three-dimensional metamaterials

    DOEpatents

    Burckel, David Bruce

    2012-06-12

    A fabrication method is capable of creating canonical metamaterial structures arrayed in a three-dimensional geometry. The method uses a membrane suspended over a cavity with predefined pattern as a directional evaporation mask. Metallic and/or dielectric material can be evaporated at high vacuum through the patterned membrane to deposit resonator structures on the interior walls of the cavity, thereby providing a unit cell of micron-scale dimension. The method can produce volumetric metamaterial structures comprising layers of such unit cells of resonator structures.

  14. Three Dimensional Dirac Semimetals

    NASA Astrophysics Data System (ADS)

    Zaheer, Saad

    2014-03-01

    Dirac points on the Fermi surface of two dimensional graphene are responsible for its unique electronic behavior. One can ask whether any three dimensional materials support similar pseudorelativistic physics in their bulk electronic spectra. This possibility has been investigated theoretically and is now supported by two successful experimental demonstrations reported during the last year. In this talk, I will summarize the various ways in which Dirac semimetals can be realized in three dimensions with primary focus on a specific theory developed on the basis of representations of crystal spacegroups. A three dimensional Dirac (Weyl) semimetal can appear in the presence (absence) of inversion symmetry by tuning parameters to the phase boundary separating a bulk insulating and a topological insulating phase. More generally, we find that specific rules governing crystal symmetry representations of electrons with spin lead to robust Dirac points at high symmetry points in the Brillouin zone. Combining these rules with microscopic considerations identifies six candidate Dirac semimetals. Another method towards engineering Dirac semimetals involves combining crystal symmetry and band inversion. Several candidate materials have been proposed utilizing this mechanism and one of the candidates has been successfully demonstrated as a Dirac semimetal in two independent experiments. Work carried out in collaboration with: Julia A. Steinberg, Steve M. Young, J.C.Y. Teo, C.L. Kane, E.J. Mele and Andrew M. Rappe.

  15. Similarity solution to three dimensional boundary layer flow of second grade nanofluid past a stretching surface with thermal radiation and heat source/sink

    SciTech Connect

    Hayat, T.; Muhammad, Taseer; Shehzad, S. A.; Alsaedi, A.

    2015-01-15

    Development of human society greatly depends upon solar energy. Heat, electricity and water from nature can be obtained through solar power. Sustainable energy generation at present is a critical issue in human society development. Solar energy is regarded one of the best sources of renewable energy. Hence the purpose of present study is to construct a model for radiative effects in three-dimensional of nanofluid. Flow of second grade fluid by an exponentially stretching surface is considered. Thermophoresis and Brownian motion effects are taken into account in presence of heat source/sink and chemical reaction. Results are derived for the dimensionless velocities, temperature and concentration. Graphs are plotted to examine the impacts of physical parameters on the temperature and concentration. Numerical computations are presented to examine the values of skin-friction coefficients, Nusselt and Sherwood numbers. It is observed that the values of skin-friction coefficients are more for larger values of second grade parameter. Moreover the radiative effects on the temperature and concentration are quite reverse.

  16. MESA meets MURaM. Surface effects in main-sequence solar-like oscillators computed using three-dimensional radiation hydrodynamics simulations

    NASA Astrophysics Data System (ADS)

    Ball, W. H.; Beeck, B.; Cameron, R. H.; Gizon, L.

    2016-08-01

    Context. Space-based observations of solar-like oscillators have identified large numbers of stars in which many individual mode frequencies can be precisely measured. However, current stellar models predict oscillation frequencies that are systematically affected by simplified modelling of the near-surface layers. Aims: We use three-dimensional radiation hydrodynamics simulations to better model the near-surface equilibrium structure of dwarfs with spectral types F3, G2, K0 and K5, and examine the differences between oscillation mode frequencies computed in stellar models with and without the improved near-surface equilibrium structure. Methods: We precisely match stellar models to the simulations' gravities and effective temperatures at the surface, and to the temporally- and horizontally-averaged densities and pressures at their deepest points. We then replace the near-surface structure with that of the averaged simulation and compute the change in the oscillation mode frequencies. We also fit the differences using several parametric models currently available in the literature. Results: The surface effect in the stars of solar-type and later is qualitatively similar and changes steadily with decreasing effective temperature. In particular, the point of greatest frequency difference decreases slightly as a fraction of the acoustic cut-off frequency and the overall scale of the surface effect decreases. The surface effect in the hot, F3-type star follows the same trend in scale (i.e. it is larger in magnitude) but shows a different overall variation with mode frequency. We find that a two-term fit using the cube and inverse of the frequency divided by the mode inertia is best able to reproduce the surface terms across all four spectral types, although the scaled solar term and a modified Lorentzian function also match the three cooler simulations reasonably well. Conclusions: Three-dimensional radiation hydrodynamics simulations of near-surface convection can be

  17. Three-dimensional registration of synchrotron radiation-based micro-computed tomography images with advanced laboratory micro-computed tomography data from murine kidney casts

    NASA Astrophysics Data System (ADS)

    Thalmann, Peter; Hieber, Simone E.; Schulz, Georg; Deyhle, Hans; Khimchenko, Anna; Kurtcuoglu, Vartan; Olgac, Ufuk; Marmaras, Anastasios; Kuo, Willy; Meyer, Eric P.; Beckmann, Felix; Herzen, Julia; Ehrbar, Stefanie; Müller, Bert

    2014-09-01

    Malfunction of oxygen regulation in kidney and liver may lead to the pathogenesis of chronic diseases. The underlying mechanisms are poorly understood. In kidney, it is hypothesized that renal gas shunting from arteries to veins eliminates excess oxygen. Such shunting is highly dependent on the structure of the renal vascular network. The vascular tree has so far not been quantified under maintenance of its connectivity as three-dimensional imaging of the vessel tree down to the smallest capillaries, which in mouse model are smaller than 5 μm in diameter, is a challenging task. An established protocol uses corrosion casts and applies synchrotron radiation-based micro-computed tomography (SRμCT), which provides the desired spatial resolution with the necessary contrast. However, SRμCT is expensive and beamtime access is limited. We show here that measurements with a phoenix nanotomrm (General Electric, Wunstorf, Germany) can provide comparable results to those obtained with SRμCT, except for regions with small vessel structures, where the signal-to-noise level was significantly reduced. For this purpose the nanotom®m measurement was compared with its corresponding measurement acquired at the beamline P05 at PETRA III at DESY, Hamburg, Germany.

  18. Dosimetric Comparison of High-Dose-Rate Brachytherapy and Intensity-Modulated Radiation Therapy as a Boost to the Prostate

    SciTech Connect

    Hermesse, Johanne; Biver, Sylvie; Jansen, Nicolas; Lenaerts, Eric; Nickers, Philippe

    2010-01-15

    Purpose: We compared the dose conformity of two radiation modalities: high-dose-rate brachytherapy (HDR BT) and intensity-modulated radiation therapy (IMRT) to deliver a boost to the prostate after external beam radiotherapy (EBRT). Methods and Materials: Ten successive patients with prostate adenocarcinoma treated with a single 10-Gy HDR BT boost after EBRT were investigated. Four theoretical IMRT plans were computed: (a) 32.85 Gy IMRT and (b) 26 Gy IMRT with CTV-PTV expansions, doses corresponding to the equivalent dose in 2-Gy fractions (EQD2) of one 10-Gy fraction calculated with a prostate alpha/beta ratio of respectively 1.5 and 3 Gy; and (c) 32.85 Gy IMRT and (d) 26 Gy IMRT without CTV-PTV expansions. The dose-volume histogram values converted in EQD2 with an alpha/beta ratio of 3 Gy for the organs at risk were compared. Results: The HDR BT plan delivered higher mean doses to the PTV compared with IMRT plans. In all, 33% of the rectal volume received a mean dose of 5.32 +- 0.65 Gy and 20% of bladder volume received 4.61 +- 1.24 Gy with HDR BT. In comparison, doses delivered with IMRT were respectively 13.4 +- 1.49 Gy and 10.81 +- 4 Gy, even if only 26 Gy was prescribed to the PTV with no CTV-PTV expansion (p < 0.0001). The hot spots inside the urethra were greater with HDR BT but acceptable. Conclusions: Use of HDR BT produced a more conformal plan for the boost to the prostate than IMRT even without CTV-PTV expansions.

  19. A direct comparison of a depth-dependent Radiation stress formulation and a Vortex force formulation within a three-dimensional coastal ocean model

    NASA Astrophysics Data System (ADS)

    Moghimi, Saeed; Klingbeil, Knut; Gräwe, Ulf; Burchard, Hans

    2013-10-01

    In this study a model system consisting of the three-dimensional General Estuarine Transport Model (GETM) and the third generation wind wave model SWAN was developed. Both models were coupled in two-way mode. The effects of waves were included into the ocean model by implementing the depth-dependent Radiation stress formulation (RS) of Mellor (2011a) and the Vortex force formulation (VF) presented by Bennis et al. (2011). Thus, the developed model system offers a direct comparison of these two formulations. The enhancement of the vertical eddy viscosity due to the energy transfer by white capping and breaking waves was taken into account by means of injecting turbulent kinetic energy at the surface. Wave-current interaction inside the bottom boundary layer was considered as well. The implementation of both wave-averaged formulations was validated against three flume experiments. One of these experiments with long period surface waves (swell), had not been evaluated before. The validation showed the capability of the model system to reproduce the three-dimensional interaction of waves and currents. For the flume test cases the wave-induced water level changes (wave set-up and set-down) and the corresponding depth-integrated wave-averaged velocities were similar for RS and VF. Both formulations produced comparable velocity profiles for short period waves. However, for large period waves, VF overestimated the wave set-down near the main breaking points and RS showed artificial offshore-directed transport at the surface where wave shoaling was taking place. Finally the validated model system was applied to a realistic barred beach scenario. For RS and VF the resulting velocity profiles were similar after being significantly improved by a roller evolution method. Both wave-averaged formulations generally provided similar results, but some shortcomings were revealed. Although VF partly showed significant deviations from the measurements, its results were still physically

  20. WE-E-BRE-06: High-Dose Microbeam Radiation Induces Different Responses in Tumor Microenvironment Compared to Conventional Seamless Radiation in Window Chamber Tumor Models

    SciTech Connect

    Chang, S; Zhang, J; Hadsell, M; Fontanella, A; Schroeder, T; Palmer, G; Dewhirst, M; Boss, M; Berman, K

    2014-06-15

    Purpose: Microbeam radiation therapy and GRID therapy are different forms of Spatially-Fractioned Radiation Therapy (SFRT) that is fundamentally different from the conventional seamless and temporally fractionated radiation therapy. SFRT is characterized by a ultra-high dose (10s –100s Gy) dose single treatment with drastic inhomogeneity pattern of given spatial frequencies. Preclinical and limited clinical studies have shown that the SFRT treatments may offer significant improvements in reducing treatment toxicity, especially for those patients who have not benefited from the state-of-the-art radiation therapy approaches. This preliminary study aims to elucidate the underlying working mechanisms of SFRT, which currently remains poorly understood. Methods: A genetically engineered 4T1 murine mammary carcinoma cell line and nude mice skin fold window chamber were used. A nanotechnology-based 160kV x-ray irradiator delivered 50Gy (entrance dose) single treatments of microbeam or seamless radiation. Animals were in 3 groups: mock, seamless radiation, and 300μm microbeam radiation. The windows were imaged using a hyperspectral system to capture total hemoglobin/saturation, GFP fluorescence emission, RFP fluorescence emission, and vessel density at 9 time points up to 7 days post radiation. Results: We found unique physiologic changes in different tumor/normal tissue regions and differential effects between seamless and microbeam treatments. They include 1) compared to microbeam and mock radiation seamless radiation damaged more microvasculature in tumor-surrounding normal tissue, 2) a pronounced angiogenic effect was observed with vascular proliferation in the microbeam irradiated portion of the tumor days post treatment (no such effect observed in seamless and mock groups), and 3) a notable change in tumor vascular orientation was observed where vessels initially oriented parallel to the beam length were replaced by vessels running perpendicular to the irradiation

  1. High-dose mode of mortality in Tribolium: A model system for study of radiation injury and repair in non-proliferative tissues

    SciTech Connect

    Cheng, Chihing Christina.

    1989-01-01

    With appropriate doses of ionizing radiation, both the acute, or lethal-midlethal, dose-independent pattern of mortality, and the hyperacute, dose-dependent pattern, were demonstrated within a single insect genus (Tribolium). This demonstration provides resolution of apparently contradictory reports of insect radiation responses in terms of doses required to cause lethality and those based on survival time as a function of dose. A dose-dependent mortality pattern was elicited in adult Tribolium receiving high doses, viz., 300 Gy or greater; its time course was complete in 10 days, before the dose-independent pattern of mortality began. Visual observations of heavily-irradiated Tribolium suggested neural and/or neuromuscular damage, as had been previously proposed by others for lethally-irradiated wasps, flies, and mosquitoes. Results of experiments using fractionated high doses supported the suggestion that the hyperacute or high-dose mode of death is the result of damage to nonproliferative tissues. Relative resistance of a strain to the hyperacute or high-dose mode of death was not correlated with resistance to the midlethal mode, which is believed to be the result of damage to the proliferative cells of the midgut. Using the high-dose mode of death as a model of radiation damage to nonproliferative tissues, the effects of age, and of a moderate priming dose were assessed. Beetles showed age-related increase in sensitivity to the high-dose mode of death, suggesting a decline in capacity to repair radiation damage to postmitotic tissue. This correlated with a decrease (50%) in the amount of repair reflected in the sparing effect of dose-fractionation (SDF) between the age of 1 to 3 months. The age related increase in radiosensitivity was reduced by a moderate priming dose (40 or 65 Gy) given at a young age.

  2. Three dimensional ultrasonic imaging

    SciTech Connect

    Thomas, G. H.; Benson, S.; Crawford, S.

    1993-03-01

    Ultrasonic nondestructive evaluation techniques interrogate components with high frequency acoustic energy. A transducer generates the acoustic energy and converts acoustic energy to electrical signals. The acoustic energy is reflected by abrupt changes in modulus and/or density which can be caused by a defect. Thus defects reflect the ultrasonic energy which is converted into electrical signals. Ultrasonic evaluation typically provides a two dimensional image of internal defects. These images are either planar views (C-scans) or cross-sectional views (B-scans). The planar view is generated by raster scanning an ultrasonic transducer over the component and capturing the amplitude of internal reflections. Depth information is generally ignored. The cross-sectional view is generated by scanning the transducer along a single line and capturing the amplitude and time of flight for each internal reflection. The amplitude and time of flight information is converted into an image of the cross section of the component where the scan was performed. By fusing the C-scan information with the B-scan information a three dimension image of the internal structure of the component can be produced. The three dimensional image can be manipulated by rotating and slicing to produce the optimal view of the internal structure. The high frequency ultrasonic energy requires a liquid coupling media and thus applications for imaging in liquid environments are well suited to ultrasonic techniques. Examples of potential ultrasonic imaging applications are: Inside liquid filled tanks, inside the human body, and underwater.

  3. Dose-Rate Dependence of High-Dose Health Effects in Humans from Photon Radiation with Application to Radiological Terrorism

    SciTech Connect

    Strom, Daniel J.

    2005-01-14

    In 1981, as part of a symposium entitled ''The Control of Exposure of the Public to Ionizing Radiation in the Event of Accident or Attack,'' Lushbaugh, H?bner, and Fry published a paper examining ''radiation tolerance'' of various human health endpoints as a function of dose rate. This paper may not have received the notice it warrants. The health endpoints examined by Lushbaugh et al. were the lethal dose that will kill 50% of people within 60 days of exposure without medical care (LD50/60); severe bone marrow damage in healthy men; severe bone marrow damage in leukemia patients; temporary sterility (azoospermia); reduced male fertility; and late effects such as cancer. Their analysis was grounded in extensive clinical experience and anchored to a few selected data points, and based on the 1968 dose-rate dependence theory of J.L. Bateman. The Lushbaugh et al. paper did not give predictive equations for the relationships, although they were implied in the text, and the relationships were presented in a non-intuitive way. This work derives the parameters needed in Bateman's equation for each health endpoint, tabulates the results, and plots them in a more conventional manner on logarithmic scales. The results give a quantitative indication of how the human organism can tolerate more radiation dose when it is delivered at lower dose rates. For example, the LD50/60 increases from about 3 grays (300 rads) when given at very high dose rates to over 10 grays (1,000 rads) when given at much lower dose rates over periods of several months. The latter figure is borne out by the case of an individual who survived for at least 19 years after receiving doses in the range of 9 to 17 grays (900-1700 rads) over 106 days. The Lushbaugh et al. work shows the importance of sheltering when confronted with long-term exposure to radiological contamination such as would be expected from a radiological dispersion event, reactor accident, or ground-level nuclear explosion.

  4. Image Quality and Radiation Dose of CT Coronary Angiography with Automatic Tube Current Modulation and Strong Adaptive Iterative Dose Reduction Three-Dimensional (AIDR3D)

    PubMed Central

    Shen, Hesong; Dai, Guochao; Luo, Mingyue; Duan, Chaijie; Cai, Wenli; Liang, Dan; Wang, Xinhua; Zhu, Dongyun; Li, Wenru; Qiu, Jianping

    2015-01-01

    Purpose To investigate image quality and radiation dose of CT coronary angiography (CTCA) scanned using automatic tube current modulation (ATCM) and reconstructed by strong adaptive iterative dose reduction three-dimensional (AIDR3D). Methods Eighty-four consecutive CTCA patients were collected for the study. All patients were scanned using ATCM and reconstructed with strong AIDR3D, standard AIDR3D and filtered back-projection (FBP) respectively. Two radiologists who were blinded to the patients' clinical data and reconstruction methods evaluated image quality. Quantitative image quality evaluation included image noise, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR). To evaluate image quality qualitatively, coronary artery is classified into 15 segments based on the modified guidelines of the American Heart Association. Qualitative image quality was evaluated using a 4-point scale. Radiation dose was calculated based on dose-length product. Results Compared with standard AIDR3D, strong AIDR3D had lower image noise, higher SNR and CNR, their differences were all statistically significant (P<0.05); compared with FBP, strong AIDR3D decreased image noise by 46.1%, increased SNR by 84.7%, and improved CNR by 82.2%, their differences were all statistically significant (P<0.05 or 0.001). Segments with diagnostic image quality for strong AIDR3D were 336 (100.0%), 486 (96.4%), and 394 (93.8%) in proximal, middle, and distal part respectively; whereas those for standard AIDR3D were 332 (98.8%), 472 (93.7%), 378 (90.0%), respectively; those for FBP were 217 (64.6%), 173 (34.3%), 114 (27.1%), respectively; total segments with diagnostic image quality in strong AIDR3D (1216, 96.5%) were higher than those of standard AIDR3D (1182, 93.8%) and FBP (504, 40.0%); the differences between strong AIDR3D and standard AIDR3D, strong AIDR3D and FBP were all statistically significant (P<0.05 or 0.001). The mean effective radiation dose was (2.55±1.21) mSv. Conclusion

  5. Prediction of radiation-induced liver disease by Lyman normal-tissue complication probability model in three-dimensional conformal radiation therapy for primary liver carcinoma

    SciTech Connect

    Xu ZhiYong; Liang Shixiong; Zhu Ji; Zhu Xiaodong; Zhao Jiandong; Lu Haijie; Yang Yunli; Chen Long; Wang Anyu; Fu Xiaolong; Jiang Guoliang . E-mail: jianggl@21cn.com

    2006-05-01

    Purpose: To describe the probability of RILD by application of the Lyman-Kutcher-Burman normal-tissue complication (NTCP) model for primary liver carcinoma (PLC) treated with hypofractionated three-dimensional conformal radiotherapy (3D-CRT). Methods and Materials: A total of 109 PLC patients treated by 3D-CRT were followed for RILD. Of these patients, 93 were in liver cirrhosis of Child-Pugh Grade A, and 16 were in Child-Pugh Grade B. The Michigan NTCP model was used to predict the probability of RILD, and then the modified Lyman NTCP model was generated for Child-Pugh A and Child-Pugh B patients by maximum-likelihood analysis. Results: Of all patients, 17 developed RILD in which 8 were of Child-Pugh Grade A, and 9 were of Child-Pugh Grade B. The prediction of RILD by the Michigan model was underestimated for PLC patients. The modified n, m, TD{sub 5} (1) were 1.1, 0.28, and 40.5 Gy and 0.7, 0.43, and 23 Gy for patients with Child-Pugh A and B, respectively, which yielded better estimations of RILD probability. The hepatic tolerable doses (TD{sub 5}) would be MDTNL of 21 Gy and 6 Gy, respectively, for Child-Pugh A and B patients. Conclusions: The Michigan model was probably not fit to predict RILD in PLC patients. A modified Lyman NTCP model for RILD was recommended.

  6. Four-Year Efficacy, Cosmesis, and Toxicity Using Three-Dimensional Conformal External Beam Radiation Therapy to Deliver Accelerated Partial Breast Irradiation

    SciTech Connect

    Chen, Peter Y.; Wallace, Michelle; Mitchell, Christina; Grills, Inga; Kestin, Larry; Fowler, Ashley; Martinez, Alvaro; Vicini, Frank

    2010-03-15

    Purpose: This prospective study examines the use of three-dimensional conformal external beam radiation therapy (3D-CRT) to deliver accelerated partial breast irradiation (APBI). Four-year data on efficacy, cosmesis, and toxicity are presented. Methods: Patients with Stage O, I, or II breast cancer with lesions <=3 cm, negative margins, and negative nodes were eligible. The 3D-CRT delivered was 38.5 Gy in 3.85 Gy/fraction. Ipsilateral breast, ipsilateral nodal, contralateral breast, and distant failure (IBF, INF, CBF, DF) were estimated using the cumulative incidence method. Disease-free, overall, and cancer-specific survival (DFS, OS, CSS) were recorded. The National Cancer Institute Common Terminology Criteria for Adverse Events (version 3) toxicity scale was used to grade acute and late toxicities. Results: Ninety-four patients are evaluable for efficacy. Median patient age was 62 years with the following characteristics: 68% tumor size <1 cm, 72% invasive ductal histology, 77% estrogen receptor (ER) (+), 88% postmenopausal; 88% no chemotherapy and 44% with no hormone therapy. Median follow-up was 4.2 years (range, 1.3-8.3). Four-year estimates of efficacy were IBF: 1.1% (one local recurrence); INF: 0%; CBF: 1.1%; DF: 3.9%; DFS: 95%; OS: 97%; and CSS: 99%. Four (4%) Grade 3 toxicities (one transient breast pain and three fibrosis) were observed. Cosmesis was rated good/excellent in 89% of patients at 4 years. Conclusions: Four-year efficacy, cosmesis, and toxicity using 3D-CRT to deliver APBI appear comparable to other experiences with similar follow-up. However, additional patients, further follow-up, and mature Phase III data are needed to evaluate thoroughly the extent of application, limitations, and complete value of this particular form of APBI.

  7. Three-dimensional diffusion of non-sorbing species in porous sandstone: computer simulation based on X-ray microtomography using synchrotron radiation.

    PubMed

    Nakashima, Yoshito; Nakano, Tsukasa; Nakamura, Koichi; Uesugi, Kentaro; Tsuchiyama, Akira; Ikeda, Susumu

    2004-10-01

    The diffusion pathways of porous sandstone were examined by a three-dimensional (3-D) imaging technique based on X-ray computed tomography (CT) using the SPring-8 (Super Photon ring-8 GeV, Hyogo, Japan) synchrotron radiation facility. The analysis was undertaken to develop better understanding of the diffusion pathways in natural rock as a key factor in clarifying the detailed mechanism of the diffusion of radionuclides and water molecules through the pore spaces of natural barriers in underground nuclear waste disposal facilities. A cylindrical sample (diameter 4 mm, length 6 mm) of sandstone (porosity 0.14) was imaged to obtain a 3-D image set of 450(3) voxels=2.62(3) mm(3). Through cluster-labeling analysis of the 3-D image set, it was revealed that 89% of the pore space forms a single large pore-cluster responsible for macroscopic diffusive transport, while only 11% of the pore space is made up of isolated pores that are not involved in long-range diffusive transport. Computer simulations of the 3-D diffusion of non-sorbing random walkers in the largest pore cluster were performed to calculate the surface-to-volume ratio of the pore, tortuosity (diffusion coefficient in free space divided by that in porous rock). The results showed that (i) the simulated surface-to-volume ratio is about 60% of the results obtained by conventional pulsed-field-gradient proton nuclear magnetic resonance (NMR) laboratory experiments and (ii) the simulated tortuosity is five to seven times larger than the results of laboratory diffusion experiments using non-sorbing I(-) and Br(-). These discrepancies are probably attributed to the intrinsic sample heterogeneity and limited spatial resolution of the CT system. The permeability was also estimated based on the NMR diffusometry theory using the results of the random walk simulations via the Kozeny-Carman equation. The estimated permeability involved an error of about 20% compared with the permeability measured by the conventional

  8. Image guided radiation therapy boost in combination with high-dose-rate intracavitary brachytherapy for the treatment of cervical cancer

    PubMed Central

    Wang, Xianliang; Li, Jie; Yuan, Ke; Yin, Gang; Wan, Bin

    2016-01-01

    Purpose The purpose of this study was to demonstrate the dosimetric and clinical feasibility of image guided radiation therapy (IGRT) combined with high-dose-rate (HDR) intracavitary brachytherapy (ICBT) to improve dose distribution in cervical cancer treatment. Material and methods For 42 cervical cancer patients, magnetic resonance imaging (MRI) scans were acquired after completion of whole pelvic irradiation 45-46 Gy and 5 fractions of B + I (ICBT + IGRT) treatment were subsequently received. The high risk clinical target volume (HRCTV), intermediate risk clinical target volume (IRCTV), bladder, rectum, and sigmoid were contoured on the computed tomography (CT) scans. The total planning aim doses for HRCTV was D90% > 85 Gy, whilst constraints for rectum and sigmoid were D2cc < 75 Gy and D2cc < 90 Gy for bladder in terms of an equivalent dose in 2 Gy (EQD2) for external beam radiotherapy (EBRT) and brachytherapy boost. The IGRT plan was optimized on top of the ICBT dose distribution. A dosimetric comparison was made between B + I and optimized ICBT (O-ICBT) only. Results The mean D90% of HRCTV was comparable for B + I and O-ICBT (p = 0.82). For B + I plan, HRCTV D100%, IRCTV D100%, and IRCTV D90% were significantly increased by a mean of 10.52 Gy, 5.61 Gy, and 2.70 Gy, respectively (p < 0.01). The D2cc for bladder, rectum, and sigmoid were lower by a mean of 21.36, 6.78, and 10.65 Gy, respectively (p < 0.01). The mean rectum V60 Gy value over 42 patients was almost the same for both techniques but for bladder and sigmoid B + I had higher V60 Gy mean values as compared with the O-ICBT. Conclusions B + I can improve dose distribution in cervical cancer treatment; it could be useful for tumors extended beyond the reach of intracavitary/interstitial brachytherapy (IC/ISBT) or for centers that are inexperienced or ill-equipped with IC/ISBT techniques. Additional confirmatory prospective studies with larger numbers of patients and longer follow-up are required to

  9. Phase I Three-Dimensional Conformal Radiation Dose Escalation Study in Newly Diagnosed Glioblastoma: Radiation Therapy Oncology Group Trial 98-03

    SciTech Connect

    Tsien, Christina Moughan, Jennifer; Michalski, Jeff M.; Gilbert, Mark R.; Purdy, James; Simpson, Joseph; Kresel, John J.; Curran, Walter J.; Diaz, Aidnag; Mehta, Minesh P.

    2009-03-01

    Purpose: To evaluate in a Phase I trial the feasibility and toxicity of dose-escalated three-dimensional conformal radiotherapy (3D-CRT) concurrent with chemotherapy in patients with primary supratentorial glioblastoma (GBM). Methods and Materials: A total of 209 patients were enrolled. All received 46 Gy in 2-Gy fractions to the first planning target volume (PTV{sub 1}), defined as the gross tumor volume (GTV) plus 1.8 cm. A subsequent boost was given to PTV{sub 2}, defined as GTV plus 0.3 cm. Patients were stratified into two groups (Group 1: PTV{sub 2} <75 cm{sup 3}; Group 2: PTV{sub 2} {>=}75 cm{sup 3}). Four RT dose levels were evaluated: 66, 72, 78, and 84 Gy. Carmustine 80 mg/m{sup 2} was given during RT, then every 8 weeks for 6 cycles. Pretreatment characteristics were well balanced. Results: Acute and late Grade 3/4 RT-related toxicities were no more frequent at higher RT dose or with larger tumors. There were no dose-limiting toxicities (acute Grade {>=}3 irreversible central nervous system toxicities) observed on any dose level in either group. On the basis of the absence of dose-limiting toxicities, dose was escalated to 84 Gy in both groups. Late RT necrosis was noted at 66 Gy (1 patient), 72 Gy (2 patients), 78 Gy (2 patients), and 84 Gy (3 patients) in Group 1. In Group 2, late RT necrosis was noted at 78 Gy (1 patient) and 84 Gy (2 patients). Median time to RT necrosis was 8.8 months (range, 5.1-12.5 months). Median survival in Group 1 was 11.6-19.3 months. Median survival in Group 2 was 8.2-13.9 months. Conclusions: Our study shows the feasibility of delivering higher than standard (60 Gy) RT dose with concurrent chemotherapy for primary GBM, with an acceptable risk of late central nervous system toxicity.

  10. The Value of Botox-A in Acute Radiation Proctitis: Results From a Phase I/II Study Using a Three-Dimensional Scoring System

    SciTech Connect

    Vuong, Te; Waschke, Kevin; Niazi, Tamim; Richard, Carole; Parent, Josee; Liberman, Sender; Mayrand, Serge; Loungnarath, Rasmy; Stein, Barry; Devic, Slobodan

    2011-08-01

    Purpose: Acute radiation proctitis (ARP) is a common side effect of pelvic radiotherapy, and its management is challenging in daily practice. The present phase I/II study evaluates the safety and efficacy of the botulinum toxin A (BTX-A) in ARP treatment for rectal cancer patients undergoing neoadjuvant high-dose-rate endorectal brachytherapy (HDREBT). Methods and Materials: Fifteen patients, treated with neoadjuvant HDREBT, 26-Gy in 4 fractions, received the study treatment that consisted of a single injection of BTX-A into the rectal wall. The injection was performed post-HDREBT and prior to the development of ARP. The control group, 20 such patients, did not receive the BTX-A injection. Both groups had access to standard treatment with hydrocortisone rectal aerosol foam (Cortifoam) and anti-inflammatory and narcotic medication. The ARP was clinically evaluated by self-administered daily questionnaires using visual analog scores to document frequency and urgency of bowel movements, rectal burning/tenesmus, and pain symptoms before and after HDREBT. Results: At the time of this analysis, there was no observed systemic toxicity. Patient compliance with the self-administered questionnaire was 100% from week 1 to 4, 70% during week 5, and 40% during week 6. The maximum tolerated dose was established at the 100-U dose level, and noticeable mean differences were observed in bowel frequency (p = 0.016), urgency (p = 0.007), and pain (p = 0.078). Conclusions: This study confirms the feasibility and efficacy of BTX-A intervention at 100-U dose level for study patients compared to control patients. A phase III study with this dose level is planned to validate these results.

  11. Radiation-induced lung fibrosis after treatment of small cell carcinoma of the lung with very high-dose cyclophosphamide

    SciTech Connect

    Trask, C.W.; Joannides, T.; Harper, P.G.; Tobias, J.S.; Spiro, S.G.; Geddes, D.M.; Souhami, R.L.; Beverly, P.C.

    1985-01-01

    Twenty-five previously untreated patients with small cell carcinoma of the lung were treated with cyclophosphamide 160 to 200 mg/kg (with autologous bone marrow support) followed by radiotherapy (4000 cGy) to the primary site and mediastinum. No other treatment was given until relapse occurred. Nineteen patients were assessable at least 4 months after radiotherapy; of these, 15 (79%) developed radiologic evidence of fibrosis, which was symptomatic in 14 (74%). The time of onset of fibrosis was related to the volume of lung irradiated. A retrospective analysis was made of 20 consecutive patients treated with multiple-drug chemotherapy and an identical radiotherapy regimen as part of a randomized trial. Radiologic and symptomatic fibrosis was one half as frequent (35%) as in the high-dose cyclophosphamide group. Very high-dose cyclophosphamide appears to sensitize the lung to radiotherapy and promotes the production of fibrosis.

  12. [High dose rate brachytherapy].

    PubMed

    Aisen, S; Carvalho, H A; Chavantes, M C; Esteves, S C; Haddad, C M; Permonian, A C; Taier, M do C; Marinheiro, R C; Feriancic, C V

    1992-01-01

    The high dose rate brachytherapy uses a single source os 192Ir with 10Ci of nominal activity in a remote afterloading machine. This technique allows an outpatient treatment, without the inconveniences of the conventional low dose rate brachytherapy such as use of general anesthesia, rhachianesthesia, prolonged immobilization, and personal exposition to radiation. The radiotherapy department is now studying 5 basic treatment schemes concerning carcinomas of the uterine cervix, endometrium, lung, esophagus and central nervous system tumors. With the Micro Selectron HDR, 257 treatment sessions were done in 90 patients. Mostly were treated with weekly fractions, receiving a total of three to four treatments each. No complications were observed neither during nor after the procedure. Doses, fraction and ideal associations still have to be studied, so that a higher therapeutic ratio can be reached.

  13. American Society for Radiation Oncology (ASTRO) and American College of Radiology (ACR) practice guideline for the performance of high-dose-rate brachytherapy.

    PubMed

    Erickson, Beth A; Demanes, D Jeffrey; Ibbott, Geoffrey S; Hayes, John K; Hsu, I-Chow J; Morris, David E; Rabinovitch, Rachel A; Tward, Jonathan D; Rosenthal, Seth A

    2011-03-01

    High-Dose-Rate (HDR) brachytherapy is a safe and efficacious treatment option for patients with a variety of different malignancies. Careful adherence to established standards has been shown to improve the likelihood of procedural success and reduce the incidence of treatment-related morbidity. A collaborative effort of the American College of Radiology (ACR) and American Society for Therapeutic Radiation Oncology (ASTRO) has produced a practice guideline for HDR brachytherapy. The guideline defines the qualifications and responsibilities of all the involved personnel, including the radiation oncologist, physicist and dosimetrists. Review of the leading indications for HDR brachytherapy in the management of gynecologic, thoracic, gastrointestinal, breast, urologic, head and neck, and soft tissue tumors is presented. Logistics with respect to the brachytherapy implant procedures and attention to radiation safety procedures and documentation are presented. Adherence to these practice guidelines can be part of ensuring quality and safety in a successful HDR brachytherapy program.

  14. American Society for Radiation Oncology (ASTRO) and American College of Radiology (ACR) Practice Guideline for the Performance of High-Dose-Rate Brachytherapy

    SciTech Connect

    Erickson, Beth A.; Demanes, D. Jeffrey; Ibbott, Geoffrey S.; Hayes, John K.; Hsu, I-Chow J.; Morris, David E.; Rabinovitch, Rachel A.; Tward, Jonathan D.; Rosenthal, Seth A.

    2011-03-01

    High-Dose-Rate (HDR) brachytherapy is a safe and efficacious treatment option for patients with a variety of different malignancies. Careful adherence to established standards has been shown to improve the likelihood of procedural success and reduce the incidence of treatment-related morbidity. A collaborative effort of the American College of Radiology (ACR) and American Society for Therapeutic Radiation Oncology (ASTRO) has produced a practice guideline for HDR brachytherapy. The guideline defines the qualifications and responsibilities of all the involved personnel, including the radiation oncologist, physicist and dosimetrists. Review of the leading indications for HDR brachytherapy in the management of gynecologic, thoracic, gastrointestinal, breast, urologic, head and neck, and soft tissue tumors is presented. Logistics with respect to the brachytherapy implant procedures and attention to radiation safety procedures and documentation are presented. Adherence to these practice guidelines can be part of ensuring quality and safety in a successful HDR brachytherapy program.

  15. Three-dimensional marginal separation

    NASA Technical Reports Server (NTRS)

    Duck, Peter W.

    1988-01-01

    The three dimensional marginal separation of a boundary layer along a line of symmetry is considered. The key equation governing the displacement function is derived, and found to be a nonlinear integral equation in two space variables. This is solved iteratively using a pseudo-spectral approach, based partly in double Fourier space, and partly in physical space. Qualitatively, the results are similar to previously reported two dimensional results (which are also computed to test the accuracy of the numerical scheme); however quantitatively the three dimensional results are much different.

  16. Three-dimensional silicon micromachining

    NASA Astrophysics Data System (ADS)

    Azimi, S.; Song, J.; Dang, Z. Y.; Liang, H. D.; Breese, M. B. H.

    2012-11-01

    A process for fabricating arbitrary-shaped, two- and three-dimensional silicon and porous silicon components has been developed, based on high-energy ion irradiation, such as 250 keV to 1 MeV protons and helium. Irradiation alters the hole current flow during subsequent electrochemical anodization, allowing the anodization rate to be slowed or stopped for low/high fluences. For moderate fluences the anodization rate is selectively stopped only at depths corresponding to the high defect density at the end of ion range, allowing true three-dimensional silicon machining. The use of this process in fields including optics, photonics, holography and nanoscale depth machining is reviewed.

  17. A Treatment Planning Method for Sequentially Combining Radiopharmaceutical Therapy and External Radiation Therapy;External beam therapy; Radiopharmaceutical therapy; Three-dimensional dosimetry; Treatment planning

    SciTech Connect

    Hobbs, Robert F.; McNutt, Todd; Baechler, Sebastien; He Bin; Esaias, Caroline E.; Frey, Eric C.; Loeb, David M.; Wahl, Richard L.; Shokek, Ori; Sgouros, George

    2011-07-15

    Purpose: Effective cancer treatment generally requires combination therapy. The combination of external beam therapy (XRT) with radiopharmaceutical therapy (RPT) requires accurate three-dimensional dose calculations to avoid toxicity and evaluate efficacy. We have developed and tested a treatment planning method, using the patient-specific three-dimensional dosimetry package 3D-RD, for sequentially combined RPT/XRT therapy designed to limit toxicity to organs at risk. Methods and Materials: The biologic effective dose (BED) was used to translate voxelized RPT absorbed dose (D{sub RPT}) values into a normalized total dose (or equivalent 2-Gy-fraction XRT absorbed dose), NTD{sub RPT} map. The BED was calculated numerically using an algorithmic approach, which enabled a more accurate calculation of BED and NTD{sub RPT}. A treatment plan from the combined Samarium-153 and external beam was designed that would deliver a tumoricidal dose while delivering no more than 50 Gy of NTD{sub sum} to the spinal cord of a patient with a paraspinal tumor. Results: The average voxel NTD{sub RPT} to tumor from RPT was 22.6 Gy (range, 1-85 Gy); the maximum spinal cord voxel NTD{sub RPT} from RPT was 6.8 Gy. The combined therapy NTD{sub sum} to tumor was 71.5 Gy (range, 40-135 Gy) for a maximum voxel spinal cord NTD{sub sum} equal to the maximum tolerated dose of 50 Gy. Conclusions: A method that enables real-time treatment planning of combined RPT-XRT has been developed. By implementing a more generalized conversion between the dose values from the two modalities and an activity-based treatment of partial volume effects, the reliability of combination therapy treatment planning has been expanded.

  18. Brachial Plexus-Associated Neuropathy After High-Dose Radiation Therapy for Head-and-Neck Cancer

    SciTech Connect

    Chen, Allen M.; Hall, William H.; Li, Judy; Beckett, Laurel; Farwell, D. Gregory; Lau, Derick H.; Purdy, James A.

    2012-09-01

    Purpose: To identify clinical and treatment-related predictors of brachial plexus-associated neuropathies after radiation therapy for head-and-neck cancer. Methods and Materials: Three hundred thirty patients who had previously completed radiation therapy for head-and-neck cancer were prospectively screened using a standardized instrument for symptoms of neuropathy thought to be related to brachial plexus injury. All patients were disease-free at the time of screening. The median time from completion of radiation therapy was 56 months (range, 6-135 months). One-hundred fifty-five patients (47%) were treated by definitive radiation therapy, and 175 (53%) were treated postoperatively. Radiation doses ranged from 50 to 74 Gy (median, 66 Gy). Intensity-modulated radiation therapy was used in 62% of cases, and 133 patients (40%) received concurrent chemotherapy. Results: Forty patients (12%) reported neuropathic symptoms, with the most common being ipsilateral pain (50%), numbness/tingling (40%), motor weakness, and/or muscle atrophy (25%). When patients with <5 years of follow-up were excluded, the rate of positive symptoms increased to 22%. On univariate analysis, the following factors were significantly associated with brachial plexus symptoms: prior neck dissection (p = 0.01), concurrent chemotherapy (p = 0.01), and radiation maximum dose (p < 0.001). Cox regression analysis confirmed that both neck dissection (p < 0.001) and radiation maximum dose (p < 0.001) were independently predictive of symptoms. Conclusion: The incidence of brachial plexus-associated neuropathies after radiation therapy for head-and-neck cancer may be underreported. In view of the dose-response relationship identified, limiting radiation dose to the brachial plexus should be considered when possible.

  19. Phase 2 Trial of Hypofractionated High-Dose Intensity Modulated Radiation Therapy With Concurrent and Adjuvant Temozolomide for Newly Diagnosed Glioblastoma

    SciTech Connect

    Iuchi, Toshihiko; Hatano, Kazuo; Kodama, Takashi; Sakaida, Tsukasa; Yokoi, Sana; Kawasaki, Koichiro; Hasegawa, Yuzo; Hara, Ryusuke

    2014-03-15

    Purpose/Objectives: To assess the effect and toxicity of hypofractionated high-dose intensity modulated radiation therapy (IMRT) with concurrent and adjuvant temozolomide (TMZ) in 46 patients with newly diagnosed glioblastoma multiforme (GBM). Methods and Materials: All patients underwent postsurgical hypofractionated high-dose IMRT. Three layered planning target volumes (PTVs) were contoured. PTV1 was the surgical cavity and residual tumor on T1-weighted magnetic resonance images with 5-mm margins, PTV2 was the area with 15-mm margins surrounding the PTV1, and PTV3 was the high-intensity area on fluid-attenuated inversion recovery images. Irradiation was performed in 8 fractions at total doses of 68, 40, and 32 Gy for PTV1, PTV2, and PTV3, respectively. Concurrent TMZ was given at 75 mg/m{sup 2}/day for 42 consecutive days. Adjuvant TMZ was given at 150 to 200 mg/m{sup 2}/day for 5 days every 28 days. Overall and progression-free survivals were evaluated. Results: No acute IMRT-related toxicity was observed. The dominant posttreatment failure pattern was dissemination. During a median follow-up time of 16.3 months (range, 4.3-80.8 months) for all patients and 23.7 months (range, 12.4-80.8 months) for living patients, the median overall survival was 20.0 months after treatment. Radiation necrosis was diagnosed in 20 patients and was observed not only in the high-dose field but also in the subventricular zone (SVZ). Necrosis in the SVZ was significantly correlated with prolonged survival (hazard ratio, 4.08; P=.007) but caused deterioration in the performance status of long-term survivors. Conclusions: Hypofractionated high-dose IMRT with concurrent and adjuvant TMZ altered the dominant failure pattern from localized to disseminated and prolonged the survival of patients with GBM. Necrosis in the SVZ was associated with better patient survival, but the benefit of radiation to this area remains controversial.

  20. Three dimensional colorimetric assay assemblies

    SciTech Connect

    Charych, D.; Reichart, A.

    2000-06-27

    A direct assay is described using novel three-dimensional polymeric assemblies which change from a blue to red color when exposed to an analyte, in one case a flu virus. The assemblies are typically in the form of liposomes which can be maintained in a suspension, and show great intensity in their color changes. Their method of production is also described.

  1. The Three-Dimensional Universe.

    ERIC Educational Resources Information Center

    Banks, Dale A.; Powell, Harry D.

    1992-01-01

    Provides instructions for helping students construct a three-dimensional model of a constellation. Aluminum foil spheres with various diameters are used to represent stars with various apparent magnitudes. The positions of the stars in the model are determined from constellation maps and by converting actual star distances into millimeters. (PR)

  2. Three-Dimensional Lissajous Figures.

    ERIC Educational Resources Information Center

    D'Mura, John M.

    1989-01-01

    Described is a mechanically driven device for generating three-dimensional harmonic space figures with different frequencies and phase angles on the X, Y, and Z axes. Discussed are apparatus, viewing stereo pairs, equations of motion, and using space figures in classroom. (YP)

  3. Creating Three-Dimensional Scenes

    ERIC Educational Resources Information Center

    Krumpe, Norm

    2005-01-01

    Persistence of Vision Raytracer (POV-Ray), a free computer program for creating photo-realistic, three-dimensional scenes and a link for Mathematica users interested in generating POV-Ray files from within Mathematica, is discussed. POV-Ray has great potential in secondary mathematics classrooms and helps in strengthening students' visualization…

  4. Three dimensional colorimetric assay assemblies

    DOEpatents

    Charych, Deborah; Reichart, Anke

    2000-01-01

    A direct assay is described using novel three-dimensional polymeric assemblies which change from a blue to red color when exposed to an analyte, in one case a flu virus. The assemblies are typically in the form of liposomes which can be maintained in a suspension, and show great intensity in their color changes. Their method of production is also described.

  5. Three-dimensional stellarator codes

    PubMed Central

    Garabedian, P. R.

    2002-01-01

    Three-dimensional computer codes have been used to develop quasisymmetric stellarators with modular coils that are promising candidates for a magnetic fusion reactor. The mathematics of plasma confinement raises serious questions about the numerical calculations. Convergence studies have been performed to assess the best configurations. Comparisons with recent data from large stellarator experiments serve to validate the theory. PMID:12140367

  6. Concomitant 5-fluorouracil infusion and high-dose radiation for stage III non-small cell lung cancer

    SciTech Connect

    Lokich, J.; Chaffey, J.; Neptune, W. )

    1989-09-01

    Thirty patients with Stage III non-small cell lung cancer were entered on a trial to evaluate the feasibility of combined radiation and concomitant 5-fluorouracil infusion. Patients had received prior debulking surgery (nine), induction chemotherapy (16), or no therapy (five). Radiation employed standard fractionation (180-200 rad/day) administered to a median cumulative dose of 5500 rad (range, 4500-6200 rad). 5-Fluorouracil was infused 24 hours per day throughout the period of radiation at a dose of 300 mg/m2/day for a median of 42 days (range, 28-56 days). Radiation complications included pneumonitis three of 30 (10%) and esophagitis (27%). Chemotherapy complications included stomatitis, two of 27 (7%), and hand-foot syndrome, three of 30 (10%). Treatment interruptions were necessary in six of 30 (20%) and four of 30 required parenteral nutrition. At a median follow-up of 12 months 26/30 (87%) maintained local control and eight had distant metastases (three of whom presented with Stage IV disease). 5-Fluorouracil delivered continuously throughout standard fractionation radiation to high cumulative doses is feasible and practical. Comparative clinical trials of the various combined radiation and chemotherapy schedules employed are in order. One additional clinical observation was the identification of six of 30 (20%) with brain metastases at presentation or after 12 months, all of whom had adenocarcinoma histologic subtype.

  7. Phase II Trial of Radiation Dose Escalation With Conformal External Beam Radiotherapy and High-Dose-Rate Brachytherapy Combined With Long-Term Androgen Suppression in Unfavorable Prostate Cancer: Feasibility Report

    SciTech Connect

    Valero, Jeanette; Cambeiro, Mauricio; Galan, Carlos; Teijeira, Mercedes; Romero, Pilar; Zudaire, Javier; Moreno, Marta; Ciervide, Raquel; Aristu, Jose Javier; Martinez-Monge, Rafael

    2010-02-01

    Purpose: To determine the feasibility of combined long-term luteinizing hormone-releasing hormone agonist-based androgen suppressive therapy (AST) and dose escalation with high-dose-rate (HDR) brachytherapy for high-risk (HRPC) or very-high-risk prostate cancer (VHRPC). Methods and Materials: Between January 2001 and October 2006, 134 patients (median age, 70 years) with either National Comprehensive Cancer Network criteria-defined HRPC (n = 47, 35.1%) or VHRPC (n = 87, 64.9%) were prospectively enrolled in this Phase II trial. Tumor characteristics included a median pretreatment prostate-specific antigen level of 14.6 ng/mL, a median clinical stage of T2c, and a median Gleason score of 7. Three-dimensional conformal radiotherapy (54 Gy in 30 fractions) was followed by HDR brachytherapy (19 Gy in 4 b.i.d. treatments). Androgen suppressive therapy started 0-3 months before three-dimensional conformal radiotherapy and continued for 2 years. Results: One implant was repositioned with a new procedure (0.7%). Five patients (3.7%) discontinued AST at a median of 13 months (range, 6-18 months) because of disease progression (n = 1), hot flashes (n = 2), fatigue (n = 1), and impotence (n = 1). After a median follow-up of 37.4 months (range, 24-90 months), the highest Radiation Therapy Oncology Group-defined late urinary toxicities were Grade 0 in 47.8%, Grade 1 in 38.1%, Grade 2 in 7.5%, and Grade 3 in 6.7% of patients. Maximal late gastrointestinal toxicities were Grade 0 in 73.1%, Grade 1 in 16.4%, Grade 2 in 7.5%, and Grade 3 in 2.9% of patients. There were no Grade 4 or 5 events. Conclusions: Intermediate-term results show that dose escalation with HDR brachytherapy combined with long-term AST is feasible and has a toxicity profile similar to that reported by previous HDR brachytherapy studies.

  8. Randomized Phase II Trial of High-Dose Melatonin and Radiation Therapy for RPA Class 2 Patients With Brain Metastases (RTOG 0119)

    SciTech Connect

    Berk, Lawrence . E-mail: Berklb@moffitt.usf.edu; Berkey, Brian; Rich, Tyvin; Hrushesky, William; Gallagher, Michael; Kudrimoti, Mahesh; McGarry, Ronald C.; Suh, John; Mehta, Minesh

    2007-07-01

    Purpose: To determine if high-dose melatonin for Radiation Therapy Oncology Group (RTOG) recursive partitioning analysis (RPA) Class 2 patients with brain metastases improved survival over historical controls, and to determine if the time of day melatonin was given affected its toxicity or efficacy. RTOG 0119 was a phase II randomized trial for this group of patients. Methods and Materials: RTOG RPA Class 2 patients with brain metastases were randomized to 20 mg of melatonin, given either in the morning (8-9 AM) or in the evening (8-9 PM). All patients received radiation therapy (30 Gy in 10 fractions) in the afternoon. Melatonin was continued until neurologic deterioration or death. The primary endpoint was overall survival time. Neurologic deterioration, as reflected by the Mini-Mental Status Examination, was also measured. Results: Neither of the randomized groups had survival distributions that differed significantly from the historic controls of patients treated with whole-brain radiotherapy. The median survivals of the morning and evening melatonin treatments were 3.4 and 2.8 months, while the RTOG historical control survival was 4.1 months. Conclusions: High-dose melatonin did not show any beneficial effect in this group of patients.

  9. The susceptibility of TaOx-based memristors to high dose rate ionizing radiation and total ionizing dose

    SciTech Connect

    McLain, Michael Lee; Sheridan, Timothy J.; Hjalmarson, Harold Paul; Mickel, Patrick R.; Hanson, Donald J.; McDonald, Joseph K.; Hughart, David Russell; Marinella, Matthew J.

    2014-11-11

    This paper investigates the effects of high dose rate ionizing radiation and total ionizing dose (TID) on tantalum oxide (TaOx) memristors. Transient data were obtained during the pulsed exposures for dose rates ranging from approximately 5.0 ×107 rad(Si)/s to 4.7 ×108 rad(Si)/s and for pulse widths ranging from 50 ns to 50 μs. The cumulative dose in these tests did not appear to impact the observed dose rate response. Static dose rate upset tests were also performed at a dose rate of ~3.0 ×108 rad(Si)/s. This is the first dose rate study on any type of memristive memory technology. In addition to assessing the tolerance of TaOx memristors to high dose rate ionizing radiation, we also evaluated their susceptibility to TID. The data indicate that it is possible for the devices to switch from a high resistance off-state to a low resistance on-state in both dose rate and TID environments. The observed radiation-induced switching is dependent on the irradiation conditions and bias configuration. Furthermore, the dose rate or ionizing dose level at which a device switches resistance states varies from device to device; the enhanced susceptibility observed in some devices is still under investigation. As a result, numerical simulations are used to qualitatively capture the observed transient radiation response and provide insight into the physics of the induced current/voltages.

  10. Combined Hydration and Antibiotics with Lisinopril to Mitigate Acute and Delayed High-dose Radiation Injuries to Multiple Organs.

    PubMed

    Fish, Brian L; Gao, Feng; Narayanan, Jayashree; Bergom, Carmen; Jacobs, Elizabeth R; Cohen, Eric P; Moulder, John E; Orschell, Christie M; Medhora, Meetha

    2016-11-01

    The NIAID Radiation and Nuclear Countermeasures Program is developing medical agents to mitigate the acute and delayed effects of radiation that may occur from a radionuclear attack or accident. To date, most such medical countermeasures have been developed for single organ injuries. Angiotensin converting enzyme (ACE) inhibitors have been used to mitigate radiation-induced lung, skin, brain, and renal injuries in rats. ACE inhibitors have also been reported to decrease normal tissue complication in radiation oncology patients. In the current study, the authors have developed a rat partial-body irradiation (leg-out PBI) model with minimal bone marrow sparing (one leg shielded) that results in acute and late injuries to multiple organs. In this model, the ACE inhibitor lisinopril (at ~24 mg m d started orally in the drinking water at 7 d after irradiation and continued to ≥150 d) mitigated late effects in the lungs and kidneys after 12.5-Gy leg-out PBI. Also in this model, a short course of saline hydration and antibiotics mitigated acute radiation syndrome following doses as high as 13 Gy. Combining this supportive care with the lisinopril regimen mitigated overall morbidity for up to 150 d after 13-Gy leg-out PBI. Furthermore, lisinopril was an effective mitigator in the presence of the growth factor G-CSF (100 μg kg d from days 1-14), which is FDA-approved for use in a radionuclear event. In summary, by combining lisinopril (FDA-approved for other indications) with hydration and antibiotics, acute and delayed radiation injuries in multiple organs were mitigated. PMID:27682899

  11. Combined Hydration and Antibiotics with Lisinopril to Mitigate Acute and Delayed High-dose Radiation Injuries to Multiple Organs.

    PubMed

    Fish, Brian L; Gao, Feng; Narayanan, Jayashree; Bergom, Carmen; Jacobs, Elizabeth R; Cohen, Eric P; Moulder, John E; Orschell, Christie M; Medhora, Meetha

    2016-11-01

    The NIAID Radiation and Nuclear Countermeasures Program is developing medical agents to mitigate the acute and delayed effects of radiation that may occur from a radionuclear attack or accident. To date, most such medical countermeasures have been developed for single organ injuries. Angiotensin converting enzyme (ACE) inhibitors have been used to mitigate radiation-induced lung, skin, brain, and renal injuries in rats. ACE inhibitors have also been reported to decrease normal tissue complication in radiation oncology patients. In the current study, the authors have developed a rat partial-body irradiation (leg-out PBI) model with minimal bone marrow sparing (one leg shielded) that results in acute and late injuries to multiple organs. In this model, the ACE inhibitor lisinopril (at ~24 mg m d started orally in the drinking water at 7 d after irradiation and continued to ≥150 d) mitigated late effects in the lungs and kidneys after 12.5-Gy leg-out PBI. Also in this model, a short course of saline hydration and antibiotics mitigated acute radiation syndrome following doses as high as 13 Gy. Combining this supportive care with the lisinopril regimen mitigated overall morbidity for up to 150 d after 13-Gy leg-out PBI. Furthermore, lisinopril was an effective mitigator in the presence of the growth factor G-CSF (100 μg kg d from days 1-14), which is FDA-approved for use in a radionuclear event. In summary, by combining lisinopril (FDA-approved for other indications) with hydration and antibiotics, acute and delayed radiation injuries in multiple organs were mitigated.

  12. Evaluation of continuous low dose rate versus acute single high dose rate radiation combined with oncolytic viral therapy for prostate cancer

    PubMed Central

    LIU, CHUNYAN; ZHANG, YONGGANG; LIU, MINZHI MAGGIE; ZHOU, HAOMING; CHOWDHURY, WASIM H.; LUPOLD, SHAWN E.; DEWEESE, TED L.; RODRIGUEZ, RONALD

    2011-01-01

    Purpose Conditionally Replicative Adenovirus (CRAd) has been previously demonstrated to augment the activity of radiation, resulting in synergy of cell kill. However, previous models combining radiation with CRAd have not focused on the methods of radiation delivery. Materials and methods We model the combination of a novel prostate-specific CRAd, Ad5 PSE/PBN E1A-AR (Ad5: adenovirus 5; PSE: prostate-specific enhancer; PBN: rat probasin promoter; E1A: early region 1A; AR: androgen receptor), with radiation delivered both acutely and continuously, in an effort to better mimic the potential clinical modes of prostate cancer radiotherapy. Results We demonstrate that pre-treatment of cells with acute single high dose rate (HDR) radiation 24 hours prior to viral infection results in significantly enhanced viral replication and virus-mediated cell death. In addition, this combination causes increased level of γ-H2AX (Phosphorylated histone protein H2AX on serine 139), a marker of double-stranded DNA damage and an indirect measure of nuclear fragmentation. In contrast, continuous low dose rate (LDR) radiation immediately following infection of the same CRAd results in no enhancement of viral replication, and only additive effects in virus-mediated cell death. Conclusions These data provide the first direct assessment of the real-time impact of radiation on viral replication and the first comparison of the effect of radiation delivery on the efficacy of CRAd virotherapy. Our data demonstrate substantial differences in CRAd efficacy based on the mode of radiation delivery. PMID:20201650

  13. Comparative toxicity and micronuclei formation in Tribolium castaneum, Callosobruchus maculatus and Sitophilus oryzae exposed to high doses of gamma radiation.

    PubMed

    Ahmadi, Mehrdad; Mozdarani, Hossein; Abd-Alla, Adly M M

    2015-07-01

    The effects of gamma radiation on mortality and micronucleus formation in Tribolium castaneum Herbst, Callosobruchus maculatus (F.) and Sitophilus oryzae (L.) genital cells were evaluated. Two groups of healthy and active adult insects 1-3 and 8-10 days old were irradiated with various doses (50-200 Gy) gamma ray. Seven days post-irradiation; mortality rates and micronucleus formation were assessed in genital cells of the irradiated insects. The results show that with increasing gamma doses, the mortality rate of each species increased and T. castaneum and S. oryzae showed the low and high sensitivity respectively. It was shown that the micronucleus appearance in the tested insects had correlation with amount and intensity of radiation doses. Moreover our results indicate different levels in the genotoxicity of gamma radiation among the insects' genital cells under study. The frequency of micronuclei in genital cells of 1-3 days old insects exposed to 50 and 200 Gy were 12.6 and 38.8 Mn/1000 cells in T. castaneum, 20.8 and 46.8 Mn/1000 cells in C. maculatus and 16.8 and 57.2 Mn/1000 cells in S. oryzae respectively. A high sensitivity of the genital cells to irradiation exposure was seen in S. oryzae correlated with its high mortality rate compared with the other two species. These results might be indicative of inflicting chromosomal damage expressed as micronucleus in high mortality rates observed in the pest population; an indication of genotoxic effects of radiation on the studied species.

  14. Facial three-dimensional morphometry.

    PubMed

    Ferrario, V F; Sforza, C; Poggio, C E; Serrao, G

    1996-01-01

    Three-dimensional facial morphometry was investigated in a sample of 40 men and 40 women, with a new noninvasive computerized method. Subjects ranged in age between 19 and 32 years, had sound dentitions, and no craniocervical disorders. For each subject, 16 cutaneous facial landmarks were automatically collected by a system consisting of two infrared camera coupled device (CCD) cameras, real time hardware for the recognition of markers, and software for the three-dimensional reconstruction of landmarks' x, y, z coordinates. From these landmarks, 15 linear and 10 angular measurements, and four linear distance ratios were computed and averaged for sex. For all angular values, both samples showed a narrow variability and no significant gender differences were demonstrated. Conversely, all the linear measurements were significantly higher in men than in women. The highest intersample variability was observed for the measurements of facial height (prevalent vertical dimension), and the lowest for the measurements of facial depth (prevalent horizontal dimension). The proportions of upper and lower face height relative to the anterior face height showed a significant sex difference. Mean values were in good agreement with literature data collected with traditional methods. The described method allowed the direct and noninvasive calculation of three-dimensional linear and angular measurements that would be usefully applied in clinics as a supplement to the classic x-ray cephalometric analyses. PMID:8540488

  15. Dynamics of three-dimensional radiative structures during RMP assisted detached plasmas on the large helical device and its comparison with EMC3-EIRENE modeling

    NASA Astrophysics Data System (ADS)

    Pandya, Shwetang N.; Peterson, Byron J.; Kobayashi, Masahiro; Ida, Katsumi; Mukai, Kiyofumi; Sano, Ryuichi; Miyazawa, Junichi; Tanaka, Hirohiko; Masuzaki, Suguru; Akiyama, Tsuyoshi; Motojima, Gen; Ohno, Noriyasu; LHD Experiment Group

    2016-04-01

    The resonant magnetic perturbation (RMP) island introduced in the stochastic edge of the large helical device (LHD) plasma plays an important role in the stabilization of the plasma detachment (Kobayashi et al 2013 Nucl. Fusion 53 093032). The plasma enters in the sustained detachment phase in the presence of an RMP once the line averaged density exceeds a critical value with a given input power. During detachment the enhanced radiation from the stochastic edge of the LHD undergoes several spatiotemporal changes which are studied quantitatively by an infrared imaging video bolometer (IRVB) diagnostic. The experimental results are compared qualitatively and quantitatively with the radiation predicted by the 3D transport simulation with fluid model, EMC3-EIRENE. A fair amount of qualitative agreement, before and after the detachment, is reported. The issue of overestimated radiation from the model is addressed by changing the free parameters in the EMC3-EIRENE code till the total radiation and the radiation profiles match closely, within a factor of two with the experimental observations. A better quantitative match between the model and the experiment is achieved at higher cross-field impurity diffusion coefficient and lower sputtering coefficient after the detachment. In this article a comparison, the first of its kind, is established between the quantified radiation from the experiments and the synthetic image obtained from the simulation code. This exercise is aimed towards validating the model assumptions against the experimentally measured radiation.

  16. Three-dimensional data assimilation and reanalysis of radiation belt electrons: Observations of a four-zone structure using five spacecraft and the VERB code

    NASA Astrophysics Data System (ADS)

    Kellerman, A. C.; Shprits, Y. Y.; Kondrashov, D.; Subbotin, D.; Makarevich, R. A.; Donovan, E.; Nagai, T.

    2014-11-01

    Obtaining the global state of radiation belt electrons through reanalysis is an important step toward validating our current understanding of radiation belt dynamics and for identification of new physical processes. In the current study, reanalysis of radiation belt electrons is achieved through data assimilation of five spacecraft with the 3-D Versatile Electron Radiation Belt (VERB) code using a split-operator Kalman filter technique. The spacecraft data are cleaned for noise, saturation effects, and then intercalibrated on an individual energy channel basis, by considering phase space density conjunctions in the T96 field model. Reanalysis during the CRRES era reveals a never-before-reported four-zone structure in the Earth's radiation belts during the 24 March 1991 shock-induced injection superstorm: (1) an inner belt, (2) the high-energy shock-injection belt, (3) a remnant outer radiation belt, and (4) a second outer radiation belt. The third belt formed near the same time as the second belt and was later enhanced across keV to MeV energies by a second particle injection observed by CRRES and the Northern Solar Terrestrial Array riometer network. During the recovery phase of the storm, the fourth belt was created near L*=4RE, lasting for several days. Evidence is provided that the fourth belt was likely created by a dominant local heating process. This study outlines the necessity to consider all diffusive processes acting simultaneously and the advantage of supporting ground-based data in quantifying the observed radiation belt dynamics. It is demonstrated that 3-D data assimilation can resolve various nondiffusive processes and provides a comprehensive picture of the electron radiation belts.

  17. Electron paramagnetic resonance radiation dose assessment in fingernails of the victim exposed to high dose as result of an accident.

    PubMed

    Romanyukha, Alexander; Trompier, François; Reyes, Ricardo A; Christensen, Doran M; Iddins, Carol J; Sugarman, Stephen L

    2014-11-01

    In this paper, we report results of radiation dose measurements in fingernails of a worker who sustained a radiation injury to his right thumb while using 130 kVp X-ray for nondestructive testing. Clinically estimated absorbed dose was about 20-25 Gy. Electron paramagnetic resonance (EPR) dose assessment was independently carried out by two laboratories, the Naval Dosimetry Center (NDC) and French Institut de Radioprotection et de Sûreté Nucléaire (IRSN). The laboratories used different equipments and protocols to estimate doses in the same fingernail samples. NDC used an X-band transportable EPR spectrometer, e-scan produced by Bruker BioSpin, and a universal dose calibration curve. In contrast, IRSN used a more sensitive Q-band stationary spectrometer (EMXplus) with a new approach for the dose assessment (dose saturation method), derived by additional dose irradiation to known doses. The protocol used by NDC is significantly faster than that used by IRSN, nondestructive, and could be done in field conditions, but it is probably less accurate and requires more sample for the measurements. The IRSN protocol, on the other hand, potentially is more accurate and requires very small amount of sample but requires more time and labor. In both EPR laboratories, the intense radiation-induced signal was measured in the accidentally irradiated fingernails and the resulting dose assessments were different. The dose on the fingernails from the right thumb was estimated as 14 ± 3 Gy at NDC and as 19 ± 6 Gy at IRSN. Both EPR dose assessments are given in terms of tissue kerma. This paper discusses the experience gained by using EPR for dose assessment in fingernails with a stationary spectrometer versus a portable one, the reasons for the observed discrepancies in dose, and potential advantages and disadvantages of each approach for EPR measurements in fingernails.

  18. Three-dimensional ultrasonic colloidal crystals

    NASA Astrophysics Data System (ADS)

    Caleap, Mihai; Drinkwater, Bruce W.

    2016-05-01

    Colloidal assembly represents a powerful method for the fabrication of functional materials. In this article, we describe how acoustic radiation forces can guide the assembly of colloidal particles into structures that serve as microscopic elements in novel acoustic metadevices or act as phononic crystals. Using a simple three-dimensional orthogonal system, we show that a diversity of colloidal structures with orthorhombic symmetry can be assembled with megahertz-frequency (MHz) standing pressure waves. These structures allow rapid tuning of acoustic properties and provide a new platform for dynamic metamaterial applications. xml:lang="fr"

  19. An Absorbed-Dose/Dose-Rate Dependence for the Alanine-EPR Dosimetry System and Its Implications in High-Dose Ionizing Radiation Metrology

    PubMed Central

    Desrosiers, M. F.; Puhl, J. M.; Cooper, S. L.

    2008-01-01

    NIST developed the alanine dosimetry system in the early 1990s to replace radiochromic dye film dosimeters. Later in the decade the alanine system was firmly established as a transfer service for high-dose radiation dosimetry and an integral part of the internal calibration scheme supporting these services. Over the course of the last decade, routine monitoring of the system revealed a small but significant observation that, after examination, led to the characterization of a previously unknown absorbed-dose-dependent, dose-rate effect for the alanine system. Though the potential impact of this effect is anticipated to be extremely limited for NIST’s customer-based transfer dosimetry service, much greater implications may be realized for international measurement comparisons between National Measurement Institutes. PMID:27096113

  20. Image-guided high-dose-rate brachytherapy: preliminary outcomes and toxicity of a joint interventional radiology and radiation oncology technique for achieving local control in challenging cases

    PubMed Central

    Kishan, Amar U.; Lee, Edward W.; McWilliams, Justin; Lu, David; Genshaft, Scott; Motamedi, Kambiz; Demanes, D. Jeffrey; Park, Sang June; Hagio, Mary Ann; Wang, Pin-Chieh

    2015-01-01

    Purpose To determine the ability of image-guided high-dose-rate brachytherapy (IG-HDR) to provide local control (LC) of lesions in non-traditional locations for patients with heavily pre-treated malignancies. Material and methods This retrospective series included 18 patients treated between 2012 and 2014 with IG-HDR, either in combination with external beam radiotherapy (EBRT; n = 9) or as monotherapy (n = 9). Lesions were located in the pelvis (n = 5), extremity (n = 2), abdomen/retroperitoneum (n = 9), and head/neck (n = 2). All cases were performed in conjunction between interventional radiology and radiation oncology. Toxicity was graded based on CTCAE v4.0 and local failure was determined by RECIST criteria. Kaplan-Meier analysis was performed for LC and overall survival. Results The median follow-up was 11.9 months. Two patients had localized disease at presentation; the remainder had recurrent and/or metastatic disease. Seven patients had prior EBRT, with a median equivalent dose in 2 Gy fractions (EQD2) of 47.0 Gy. The median total EQD2s were 34 Gy and 60.9 Gy for patients treated with monotherapy or combination therapy, respectively. Image-guided high-dose rate brachytherapy was delivered in one to six fractions. Six patients had local failures at a median interval of 5.27 months with a one-year LC rate of 59.3% and a one-year overall survival of 40.7%. Six patients died from their disease at a median interval of 6.85 months from the end of treatment. There were no grade ≥ 3 acute toxicities but two patients had serious long term toxicities. Conclusions We demonstrate a good one year LC rate of nearly 60%, and a favorable toxicity profile when utilizing IG-HDR to deliver high doses of radiation with high precision into targets not readily accessible by other forms of local therapy. These preliminary results suggest that further studies utilizing this approach may be considered for patients with difficult to access lesions that require LC. PMID:26622237

  1. High-Dose Split-Course Radiation Therapy for Anal Cancer: Outcome Analysis Regarding the Boost Strategy (CORS-03 Study)

    SciTech Connect

    Hannoun-Levi, Jean-Michel; Ortholan, Cecile; Resbeut, Michel; Teissier, Eric; Ronchin, Philippe; Cowen, Didier; Zaccariotto, Audrey; Benezery, Karen; Francois, Eric; Salem, Naji; Ellis, Steve; Azria, David; Gerard, Jean-Pierre

    2011-07-01

    Purpose: To retrospectively assess the clinical outcome in anal cancer patients treated with split-course radiation therapy and boosted through external-beam radiation therapy (EBRT) or brachytherapy (BCT). Methods and Materials: From January 2000 to December 2004, a selected group (162 patients) with invasive nonmetastatic anal squamous cell carcinoma was studied. Tumor staging reported was T1 = 31 patients (19%), T2 = 77 patients (48%), T3 = 42 patients (26%), and T4= 12 patients (7%). Lymph node status was N0-1 (86%) and N2-3 (14%). Patients underwent a first course of EBRT: mean dose 45.1 Gy (range, 39.5-50) followed by a boost: mean dose 17.9 Gy (range, 8-25) using EBRT (76 patients, 47%) or BCT (86 patients, 53%). All characteristics of patients and tumors were well balanced between the BCT and EBRT groups. Results: The mean overall treatment time (OTT) was 82 days (range, 45-143) and 67 days (range, 37-128) for the EBRT and BCT groups, respectively (p < 0.001). The median follow-up was 62 months (range, 2-108). The 5-year cumulative rate of local recurrence (CRLR) was 21%. In the univariate analysis, the prognostic factors for CRLR were as follows: T stage (T1-2 = 15% vs. T3-4 = 36%, p = 0.03), boost technique (BCT = 12% vs. EBRT = 33%, p = 0.002) and OTT (OTT <80 days = 14%, OTT {>=}80 days = 34%, p = 0.005). In the multivariate analysis, BCT boost was the unique prognostic factor (hazard ratio = 0.62 (0.41-0.92). In the subgroup of patients with OTT <80 days, the 5-year CRLR was significantly increased with the BCT boost (BC = 9% vs. EBRT = 28%, p = 0.03). In the case of OTT {>=}80 days, the 5-year CRLR was not affected by the boost technique (BCT = 29% vs. EBRT = 38%, p = 0.21). Conclusion: In anal cancer, when OTT is <80 days, BCT boost is superior to EBRT boost for CRLR. These results suggest investigating the benefit of BCT boost in prospective trials.

  2. Mitigation Effect of an FGF-2 Peptide on Acute Gastrointestinal Syndrome After High-Dose Ionizing Radiation

    SciTech Connect

    Zhang Lurong; Sun Weimin; Wang Jianjun; Zhang Mei; Yang Shanmin; Tian Yeping; Vidyasagar, Sadasivan; Pena, Louis A.; Zhang Kunzhong; Cao Yongbing; Yin Liangjie; Wang Wei; Zhang Lei; Schaefer, Katherine L.; Saubermann, Lawrence J.; Swarts, Steven G.; Fenton, Bruce M.; Keng, Peter C.; Okunieff, Paul

    2010-05-01

    Purpose: Acute gastrointestinal syndrome (AGS) resulting from ionizing radiation causes death within 7 days. Currently, no satisfactory agent exists for mitigation of AGS. A peptide derived from the receptor binding domain of fibroblast growth factor 2 (FGF-P) was synthesized and its mitigation effect on AGS was examined. Methods and Materials: A subtotal body irradiation (sub-TBI) model was created to induce gastrointestinal (GI) death while avoiding bone marrow death. After 10.5 to 16 Gy sub-TBI, mice received an intramuscular injection of FGF-P (10 mg/kg/day) or saline (0.2 ml/day) for 5 days; survival (frequency and duration) was measured. Crypt cells and their proliferation were assessed by hematoxylin, eosin, and BrdU staining. In addition, GI hemoccult score, stool formation, and plasma levels of endotoxin, insulin, amylase, interleukin (IL)-6, keratinocyte-derived chemokine (KC) monocyte chemoattractant protein 1 (MCP-1) and tumor necrosis factor (TNF)-alpha were evaluated. Results: Treatment with FGF-P rescued a significant fraction of four strains of mice (33-50%) exposed to a lethal dose of sub-TBI. Use of FGF-P improved crypt survival and repopulation and partially preserved or restored GI function. Furthermore, whereas sub-TBI increased plasma endotoxin levels and several pro-inflammation cytokines (IL-6, KC, MCP-1, and TNF-alpha), FGF-P reduced these adverse responses. Conclusions: The study data support pursuing FGF-P as a mitigator for AGS.

  3. Hypofractionated High-Dose Radiation Therapy for Prostate Cancer: Long-Term Results of a Multi-Institutional Phase II Trial

    SciTech Connect

    Fonteyne, Valerie; Soete, Guy; Arcangeli, Stefano; De Neve, Wilfried; Rappe, Bernard; Storme, Guy; Strigari, Lidia; Arcangeli, Giorgio; De Meerleer, Gert

    2012-11-15

    Purpose: To report late gastrointestinal (GI) and genitourinary (GU) toxicity, biochemical and clinical outcomes, and overall survival after hypofractionated radiation therapy for prostate cancer (PC). Methods and Materials: Three institutions included 113 patients with T1 to T3N0M0 PC in a phase II study. Patients were treated with 56 Gy in 16 fractions over 4 weeks. Late toxicity was scored using Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria extended with additional symptoms. Biochemical outcome was reported according to the Phoenix definition for biochemical failure. Results: The incidence of late GI and GU toxicity was low. The 3-year actuarial risk of developing late GU and GI toxicity of grade {>=}2 was 13% and 8% respectively. Five-year biochemical non-evidence of disease (bNED) was 94%. Risk group, T stage, and deviation from planned hormone treatment were significant predictive factors for bNED. Deviation from hormone treatment remained significant in multivariate analysis. Five-year clinical non evidence of disease and overall survival was 95% and 91% respectively. No patient died from PC. Conclusions: Hypofractionated high-dose radiation therapy is a valuable treatment option for patients with PC, with excellent biochemical and clinical outcome and low toxicity.

  4. Sexual Functioning Among Endometrial Cancer Patients Treated With Adjuvant High-Dose-Rate Intra-Vaginal Radiation Therapy

    SciTech Connect

    Damast, Shari; Alektiar, Kaled M.; Goldfarb, Shari; Eaton, Anne; Patil, Sujata; Mosenkis, Jeffrey; Bennett, Antonia; Atkinson, Thomas; Jewell, Elizabeth; Leitao, Mario; Barakat, Richard; Carter, Jeanne; Basch, Ethan

    2012-10-01

    Purpose: We used the Female Sexual Function Index (FSFI) to investigate the prevalence of sexual dysfunction (SD) and factors associated with diminished sexual functioning in early stage endometrial cancer (EC) patients treated with simple hysterectomy and adjuvant brachytherapy. Methods and Materials: A cohort of 104 patients followed in a radiation oncology clinic completed questionnaires to quantify current levels of sexual functioning. The time interval between hysterectomy and questionnaire completion ranged from <6 months to >5 years. Multivariate regression was performed using the FSFI as a continuous variable (score range, 1.2-35.4). SD was defined as an FSFI score of <26, based on the published validation study. Results: SD was reported by 81% of respondents. The mean ({+-} standard deviation) domain scores in order of highest-to-lowest functioning were: satisfaction, 2.9 ({+-}2.0); orgasm, 2.5 ({+-}2.4); desire, 2.4 ({+-}1.3); arousal, 2.2 ({+-}2.0); dryness, 2.1 ({+-}2.1); and pain, 1.9 ({+-}2.3). Compared to the index population in which the FSFI cut-score was validated (healthy women ages 18-74), all scores were low. Compared to published scores of a postmenopausal population, scores were not statistically different. Multivariate analysis isolated factors associated with lower FSFI scores, including having laparotomy as opposed to minimally invasive surgery (effect size, -7.1 points; 95% CI, -11.2 to -3.1; P<.001), lack of vaginal lubricant use (effect size, -4.4 points; 95% CI, -8.7 to -0.2, P=.040), and short time interval (<6 months) from hysterectomy to questionnaire completion (effect size, -4.6 points; 95% CI, -9.3-0.2; P=.059). Conclusions: The rate of SD, as defined by an FSFI score <26, was prevalent. The postmenopausal status of EC patients alone is a known risk factor for SD. Additional factors associated with poor sexual functioning following treatment for EC included receipt of laparotomy and lack of vaginal lubricant use.

  5. Three-dimensional visual stimulator

    NASA Astrophysics Data System (ADS)

    Takeda, Tsunehiro; Fukui, Yukio; Hashimoto, Keizo; Hiruma, Nobuyuki

    1995-02-01

    We describe a newly developed three-dimensional visual stimulator (TVS) that can change independently the directions, distances, sizes, luminance, and varieties of two sets of targets for both eyes. It consists of liquid crystal projectors (LCP's) that generate the flexible images of targets, Badal otometers that change target distances without changing the visual angles, and relay-lens systems that change target directions. A special control program is developed for real-time control of six motors and two LCP's in the TVS together with a three-dimensional optometer III that simultaneously measures eye movement, accommodation, pupil diameter, and head movement. distance, 0 to -20 D; direction, 16 horizontally and 15 vertically; size, 0-2 deg visual angle; and luminance, 10-2-10 2 cd/m2. The target images are refreshed at 60 Hz and speeds with which the target makes a smooth change (ramp stimuli) are size, 10 deg/s. A simple application demonstrates the performance.

  6. Three dimensional data-assimilative VERB-code simulations of the Earth's radiation belts: Reanalysis during the Van Allen Probe era, and operational forecasting

    NASA Astrophysics Data System (ADS)

    Kellerman, Adam; Shprits, Yuri; Podladchikova, Tatiana; Kondrashov, Dmitri

    2016-04-01

    The Versatile Electron Radiation Belt (VERB) code 2.0 models the dynamics of radiation-belt electron phase space density (PSD) in Earth's magnetosphere. Recently, a data-assimilative version of this code has been developed, which utilizes a split-operator Kalman-filtering approach to solve for electron PSD in terms of adiabatic invariants. A new dataset based on the TS07d magnetic field model is presented, which may be utilized for analysis of past geomagnetic storms, and for initial and boundary conditions in running simulations. Further, a data-assimilative forecast model is introduced, which has the capability to forecast electron PSD several days into the future, given a forecast Kp index. The model assimilates an empirical model capable of forecasting the conditions at geosynchronous orbit. The model currently runs in real time and a forecast is available to view online http://rbm.epss.ucla.edu.

  7. SU-E-T-514: Simultaneously Determination of Radiation Isocentricity of Gantry, Collimator and Couch Using a Commercial Three-Dimensional Dosimetry QA Apparatus

    SciTech Connect

    Yan, S; Song, H; Wu, Q

    2014-06-01

    Purpose: Radiation isocentricity is an important benchmark for a LINAC and is typically determined by 3 separate film star-shots. We developed a technique to simultaneously determine the radiation isocenter of gantry, collimator and couch with a commercial 3D QA apparatus. Methods: The ArcCHECK from SunNuclear was used on two LINACs. It was aligned with room lasers. For gantry rotation, collimator and couch were set to zero and gantry was placed to 0, 49, 213 and 311 degrees. Similarly, a set of collimator/couch angles were chosen with the other two axes at neutral positions. The measured dose matrices were analyzed by an in-house MATLAB program. For each shot, the central axis was determined by computing the FWHM of the diode arrays. The largest inscribed circle from these central axis lines was used to determine isocenter: the radius as the benchmark of isocentricity and the coordinates of the center as the discrepancy of radiation isocenter to the origin defined by lasers. To validate the method, the couch was shifted by ~5 mm in all three directions and measurements were repeated. Results: The radius of the largest inscribed circle for gantry, collimator and couch are (0.3, 0.5, 0.2) mm for one LINAC and (0.2, 0.3, 0.1) mm for the other, in agreement with the film star-shots at annual QA. The discrepancies of radiation isocenter are generally within 1 mm, except gantry rotation on one LINAC due to the drift of foot laser. The differences in positions detected are consistent with the intentional predefined shift. Conclusion: We have demonstrated a technique for the simultaneous measurement of gantry, collimator, and couch isocentricity with a set of carefully chosen irradiation parameters based on the specific construction geometry of the 3D detector ArcCheck. This can replace the standard film star-shots. The future work includes improving operation efficiency.

  8. Three-dimensional study of the multi-cavity FEL

    SciTech Connect

    Krishnagopal, S.; Kumar, V.

    1995-12-31

    The Multi-Cavity Free-Electron Laser has been proposed earlier, as a new configuration to obtain short, intense pulses of radiation, the key idea being to pre-bunch the electron beam in a number of very short cavities. Those studies were one-dimensional. Here we use three-dimensional simulations to study the viability of this concept when three-dimensional effects are included, particularly with regard to the transverse modes of the optical beam.

  9. Development of a minipig model for lung injury induced by a single high-dose radiation exposure and evaluation with thoracic computed tomography

    PubMed Central

    Lee, Jong-Geol; Park, Sunhoo; Bae, Chang-Hwan; Jang, Won-Suk; Lee, Sun-Joo; Lee, Dal Nim; Myung, Jae Kyung; Kim, Cheol Hyeon; Jin, Young-Woo; Lee, Seung-Sook; Shim, Sehwan

    2016-01-01

    Radiation-induced lung injury (RILI) due to nuclear or radiological exposure remains difficult to treat because of insufficient clinical data. The goal of this study was to establish an appropriate and efficient minipig model and introduce a thoracic computed tomography (CT)-based method to measure the progression of RILI. Göttingen minipigs were allocated to control and irradiation groups. The most obvious changes in the CT images after irradiation were peribronchial opacification, interlobular septal thickening, and lung volume loss. Hounsfield units (HU) in the irradiation group reached a maximum level at 6 weeks and decreased thereafter, but remained higher than those of the control group. Both lung area and cardiac right lateral shift showed significant changes at 22 weeks post irradiation. The white blood cell (WBC) count, a marker of pneumonitis, increased and reached a maximum at 6 weeks in both peripheral blood and bronchial alveolar lavage fluid. Microscopic findings at 22 weeks post irradiation were characterized by widening of the interlobular septum, with dense fibrosis and an increase in the radiation dose–dependent fibrotic score. Our results also showed that WBC counts and microscopic findings were positively correlated with the three CT parameters. In conclusion, the minipig model can provide useful clinical data regarding RILI caused by the adverse effects of high-dose radiotherapy. Peribronchial opacification, interlobular septal thickening, and lung volume loss are three quantifiable CT parameters that can be used as a simple method for monitoring the progression of RILI. PMID:26712795

  10. Three-dimensional coil inductor

    DOEpatents

    Bernhardt, Anthony F.; Malba, Vincent

    2002-01-01

    A three-dimensional coil inductor is disclosed. The inductor includes a substrate; a set of lower electrically conductive traces positioned on the substrate; a core placed over the lower traces; a set of side electrically conductive traces laid on the core and the lower traces; and a set of upper electrically conductive traces attached to the side traces so as to form the inductor. Fabrication of the inductor includes the steps of forming a set of lower traces on a substrate; positioning a core over the lower traces; forming a set of side traces on the core; connecting the side traces to the lower traces; forming a set of upper traces on the core; and connecting the upper traces to the side traces so as to form a coil structure.

  11. Three-dimensional aromatic networks.

    PubMed

    Toyota, Shinji; Iwanaga, Tetsuo

    2014-01-01

    Three-dimensional (3D) networks consisting of aromatic units and linkers are reviewed from various aspects. To understand principles for the construction of such compounds, we generalize the roles of building units, the synthetic approaches, and the classification of networks. As fundamental compounds, cyclophanes with large aromatic units and aromatic macrocycles with linear acetylene linkers are highlighted in terms of transannular interactions between aromatic units, conformational preference, and resolution of chiral derivatives. Polycyclic cage compounds are constructed from building units by linkages via covalent bonds, metal-coordination bonds, or hydrogen bonds. Large cage networks often include a wide range of guest species in their cavity to afford novel inclusion compounds. Topological isomers consisting of two or more macrocycles are formed by cyclization of preorganized species. Some complicated topological networks are constructed by self-assembly of simple building units.

  12. Radiation boundary conditions for the numerical solution of the three-dimensional time-dependent Schroedinger equation with a localized interaction

    SciTech Connect

    Heinen, M.; Kull, H.-J.

    2009-05-15

    Exact radiation boundary conditions on the surface of a sphere are presented for the single-particle time-dependent Schroedinger equation with a localized interaction. With these boundary conditions, numerical computations of spatially unbounded outgoing wave solutions can be restricted to the finite volume of a sphere. The boundary conditions are expressed in terms of the free-particle Green's function for the outside region. The Green's function is analytically calculated by an expansion in spherical harmonics and by the method of Laplace transformation. For each harmonic number a discrete boundary condition between the function values at adjacent radial grid points is obtained. The numerical method is applied to quantum tunneling through a spherically symmetric potential barrier with different angular-momentum quantum numbers l. Calculations for l=0 are compared to exact theoretical results.

  13. THE 2-3 kHz HELIOSPHERIC RADIATION, THE IBEX RIBBON, AND THE THREE-DIMENSIONAL SHAPE OF THE HELIOPAUSE

    SciTech Connect

    Fuselier, Stephen A.; Cairns, Iver H.

    2013-07-10

    Recent Interstellar Boundary Explorer (IBEX) observations indicate that the total dynamic pressure in the interstellar medium is closely partitioned between the plasma and the magnetic field, with an Alfven Mach number M{sub A} {approx} 1 and a sonic Mach number {approx}2. Observations of the IBEX Ribbon provide a unique determination of the orientation of the undraped interstellar magnetic field along the heliopause. There is also a striking correspondence between the Ribbon location and the source locations of 2-3 kHz radiation determined from Voyager observations: the radiation sources north of the ecliptic form a line parallel to but offset by about 30 Degree-Sign from the Ribbon. A general Rankine-Hugoniot analysis is used to argue that the heliopause should not be symmetric about the velocity vector V{sub ISM} of the interstellar medium relative to the Sun (the nominal nose direction). Furthermore, the closest point on the heliopause to the Sun should be on the Ribbon for M{sub A} = 0 and at least 9 Degree-Sign from the nominal nose direction toward the Ribbon for M{sub A} = 1. These new results are combined into a conceptual model of the heliopause that includes (1) a plasma depletion layer formed as the interstellar magnetic field drapes against the heliopause, (2) a minimum inner heliosheath thickness and closest point between the Sun and heliopause along (or close to) the Ribbon rather than in the nominal nose direction (along V{sub ISM}), and (3) inference of an asymmetric heliopause shape from the angular offset of the radio sources and Ribbon and from the Rankine-Hugoniot analysis.

  14. A reference skeletal dosimetry model for an adult male radionuclide therapy patient based on three-dimensional imaging and paired-image radiation transport

    NASA Astrophysics Data System (ADS)

    Shah, Amish P.

    The need for improved patient-specificity of skeletal dose estimates is widely recognized in radionuclide therapy. Current clinical models for marrow dose are based on skeletal mass estimates from a variety of sources and linear chord-length distributions that do not account for particle escape into cortical bone. To predict marrow dose, these clinical models use a scheme that requires separate calculations of cumulated activity and radionuclide S values. Selection of an appropriate S value is generally limited to one of only three sources, all of which use as input the trabecular microstructure of an individual measured 25 years ago, and the tissue mass derived from different individuals measured 75 years ago. Our study proposed a new modeling approach to marrow dosimetry---the Paired Image Radiation Transport (PIRT) model---that properly accounts for both the trabecular microstructure and the cortical macrostructure of each skeletal site in a reference male radionuclide patient. The PIRT model, as applied within EGSnrc, requires two sets of input geometry: (1) an infinite voxel array of segmented microimages of the spongiosa acquired via microCT; and (2) a segmented ex-vivo CT image of the bone site macrostructure defining both the spongiosa (marrow, endosteum, and trabeculae) and the cortical bone cortex. Our study also proposed revising reference skeletal dosimetry models for the adult male cancer patient. Skeletal site-specific radionuclide S values were obtained for a 66-year-old male reference patient. The derivation for total skeletal S values were unique in that the necessary skeletal mass and electron dosimetry calculations were formulated from the same source bone site over the entire skeleton. We conclude that paired-image radiation-transport techniques provide an adoptable method by which the intricate, anisotropic trabecular microstructure of the skeletal site; and the physical size and shape of the bone can be handled together, for improved

  15. Short and independent characteristic methods for discrete ordinates radiation transport with two-dimensional and three-dimensional regular Cartesian meshes

    NASA Astrophysics Data System (ADS)

    Suriano, Mark Allen

    2001-07-01

    Accurate, reliable, and robust discrete neutral particle radiation transport codes are needed in order to perform realistic 3D engineering calculations. Current neutron transport codes use low order spatial quadratures that are inaccurate unless a highly refined spatial mesh is used. In this work various higher order characteristic spatial quadratures are derived, implemented, and tested. Regular meshes of rectangular (2D) and of rectangular parallelepiped (boxoid) cells are supported. Short characteristic (linear characteristic [LC] and exponential characteristic [EC]) methods are compared with the corresponding independent characteristic (ILC and IEC) methods. The latter readily provide for plane parallel implementation. All transport results were benchmarked against Monte Carlo calculations. The diamond difference (DD) method was also tested and compared to the characteristic spatial quadratures. IEC and EC were found to be robust, reliable, and accurate for thin, intermediate, and optically thick cells. LC was robust, reliable, and accurate for cells of thin to intermediate (approximately 2 mean free paths) optical thickness. ILC was not pursued in 3D due to its anticipated excessive computational cost. DD was unreliable (as expected) over the range of test problems. We conclude that IEC and EC are apt methods for a wide range of problems, and provide the ability to perform realistic engineering calculations on coarse cells given nonnegative group-to-group, ordinate-to-ordinate cross section data.

  16. Impulse response solution to the three-dimensional vector radiative transfer equation in atmosphere-ocean systems. I. Monte Carlo method.

    PubMed

    Zhai, Peng-Wang; Kattawar, George W; Yang, Ping

    2008-03-10

    We have developed a powerful 3D Monte Carlo code, as part of the Radiance in a Dynamic Ocean (RaDyO) project, which can compute the complete effective Mueller matrix at any detector position in a completely inhomogeneous turbid medium, in particular, a coupled atmosphere-ocean system. The light source can be either passive or active. If the light source is a beam of light, the effective Mueller matrix can be viewed as the complete impulse response Green matrix for the turbid medium. The impulse response Green matrix gives us an insightful way to see how each region of a turbid medium affects every other region. The present code is validated with the multicomponent approach for a plane-parallel system and the spherical harmonic discrete ordinate method for the 3D scalar radiative transfer system. Furthermore, the impulse response relation for a box-type cloud model is studied. This 3D Monte Carlo code will be used to generate impulse response Green matrices for the atmosphere and ocean, which act as inputs to a hybrid matrix operator-Monte Carlo method. The hybrid matrix operator-Monte Carlo method will be presented in part II of this paper.

  17. Long-term Survival and Toxicity in Patients Treated With High-Dose Intensity Modulated Radiation Therapy for Localized Prostate Cancer

    SciTech Connect

    Spratt, Daniel E.; Pei, Xin; Yamada, Josh; Kollmeier, Marisa A.; Cox, Brett; Zelefsky, Michael J.

    2013-03-01

    Purpose: To report long-term survival and toxicity outcomes with the use of high-dose intensity modulated radiation therapy (IMRT) to 86.4 Gy for patients with localized prostate cancer. Methods and Materials: Between August 1997 and December 2008, 1002 patients were treated to a dose of 86.4 Gy using a 5-7 field IMRT technique. Patients were stratified by prognostic risk group based on National Comprehensive Cancer Network risk classification criteria. A total of 587 patients (59%) were treated with neoadjuvant and concurrent androgen deprivation therapy. The median follow-up for the entire cohort was 5.5 years (range, 1-14 years). Results: For low-, intermediate-, and high-risk groups, 7-year biochemical relapse-free survival outcomes were 98.8%, 85.6%, and 67.9%, respectively (P<.001), and distant metastasis-free survival rates were 99.4%, 94.1%, and 82.0% (P<.001), respectively. On multivariate analysis, T stage (P<.001), Gleason score (P<.001), and >50% of initial biopsy positive core (P=.001) were predictive for distant mestastases. No prostate cancer-related deaths were observed in the low-risk group. The 7-year prostate cancer-specific mortality (PCSM) rates, using competing risk analysis for intermediate- and high-risk groups, were 3.3% and 8.1%, respectively (P=.008). On multivariate analysis, Gleason score (P=.004), percentage of biopsy core positivity (P=.003), and T-stage (P=.033) were predictive for PCSM. Actuarial 7-year grade 2 or higher late gastrointestinal and genitourinary toxicities were 4.4% and 21.1%, respectively. Late grade 3 gastrointestinal and genitourinary toxicity was experienced by 7 patients (0.7%) and 22 patients (2.2%), respectively. Of the 427 men with full potency at baseline, 317 men (74%) retained sexual function at time of last follow-up. Conclusions: This study represents the largest cohort of patients treated with high-dose radiation to 86.4 Gy, using IMRT for localized prostate cancer, with the longest follow-up to date

  18. Dosimetric comparison study between intensity modulated radiation therapy and three-dimensional conformal proton therapy for pelvic bone marrow sparing in the treatment of cervical cancer.

    PubMed

    Song, William Y; Huh, Soon N; Liang, Yun; White, Greg; Nichols, R Charles; Watkins, W Tyler; Mundt, Arno J; Mell, Loren K

    2010-08-15

    The objective was to compare intensity-modulated radiation therapy (IMRT) with 3D conformal proton therapy (3DCPT) in the treatment of cervical cancer. In particular, each technique's ability to spare pelvic bone marrow (PBM) was of primary interest in this study. A total of six cervical cancer patients (3 postoperative and 3 intact) were planned and analyzed. All plans had uniform 1.0 cm CTV-PTV margin and satisfied the 95% PTV with 100% isodose (prescription dose = 45 Gy) coverage. Dose-volume histograms (DVH) were analyzed for comparison. The overall PTV and PBM volumes were 1035.9 ± 192.2 cc and 1151.4 ± 198.3 cc, respectively. In terms of PTV dose conformity index (DCI) and dose homogeneity index (DHI), 3DCPT was slightly superior to IMRT with 1.00 ± 0.001, 1.01 ± 0.02, and 1.10 ± 0.02, 1.13 ± 0.01, respectively. In addition, 3DCPT demonstrated superiority in reducing lower doses (i.e., V30 or less) to PBM, small bowel and bladder. Particularly in PBM, average V10 and V20 reductions of 10.8% and 7.4% (p = 0.001 and 0.04), respectively, were observed. However, in the higher dose range, IMRT provided better sparing (> V30). For example, in small bowel and PBM, average reductions in V45 of 4.9% and 10.0% (p = 0.048 and 0.008), respectively, were observed. Due to its physical characteristics such as low entrance dose, spread-out Bragg peak and finite particle range of protons, 3DCPT illustrated superior target coverage uniformity and sparing of the lower doses in PBM and other organs. Further studies are, however, needed to fully exploit the benefits of protons for general use in cervical cancer.

  19. Rapid assessment of high-dose radiation exposures through scoring of cell-fusion-induced premature chromosome condensation and ring chromosomes.

    PubMed

    Lamadrid Boada, A I; Romero Aguilera, I; Terzoudi, G I; González Mesa, J E; Pantelias, G; García, O

    2013-09-18

    Analysis of premature chromosome condensation (PCC) mediated by fusion of G0-lymphocytes with mitotic CHO cells in combination with rapid visualization and quantification of rings (PCC-Rf) is proposed as an alternative technique for dose assessment of radiation-exposed individuals. Isolated lymphocytes or whole blood from six individuals were γ-irradiated with 5, 10, 15 and 20Gy at a dose rate of 0.5Gy/min. Following either 8- or 24-h post-exposure incubation of irradiated samples at 37°C, chromosome spreads were prepared by standard PCC cytogenetic procedures. The protocol for PCC fusion proved to be effective at doses as high as 20Gy, enabling the analysis of ring chromosomes and excess PCC fragments. The ring frequencies remained constant during the 8-24-h repair time; the pooled dose relationship between ring frequency (Y) and dose (D) was linear: Y=(0.088±0.005)×D. During the repair time, excess fragments decreased from 0.91 to 0.59 chromatid pieces per Gy, revealing the importance of information about the exact time of exposure for dose assessment on the basis of fragments. Compared with other cytogenetic assays to estimate radiation dose, the PCC-Rf method has the following benefits: a 48-h culture time is not required, allowing a much faster assessment of dose in comparison with conventional scoring of dicentrics and rings in assays for chemically-induced premature chromosome condensation (PCC-Rch), and it allows the analysis of heavily irradiated lymphocytes that are delayed or never reach mitosis, thus avoiding the problem of saturation at high doses. In conclusion, the use of the PCC fusion assay in conjunction with scoring of rings in G0-lymphocytes offers a suitable alternative for fast dose estimation following accidental exposure to high radiation doses.

  20. Dynamic Three-Dimensional Echocardiography

    NASA Astrophysics Data System (ADS)

    Matsusaka, Katsuhiko; Doi, Motonori; Oshiro, Osamu; Chihara, Kunihiro

    2000-08-01

    Conventional three-dimensional (3D) ultrasound imaging equipment for diagnosis requires much time to reconstruct 3D images or fix the view point for observing the 3D image. Thus, it is inconvenient for cardiac diagnosis. In this paper, we propose a new dynamic 3D echocardiography system. The system produces 3D images in real-time and permits changes in view point. This system consists of ultrasound diagnostic equipment, a digitizer and a computer. B-mode images are projected to a virtual 3D space by referring to the position of the probe of the ultrasound diagnosis equipment. The position is obtained by the digitizer to which the ultrasound probe is attached. The 3D cardiac image is constructed from B-mode images obtained simultaneously in the cardiac cycle. To obtain the same moment of heartbeat in the cardiac cycle, this system uses the electrocardiography derived from the diagnosis equipment. The 3D images, which show various scenes of the stage of heartbeat action, are displayed sequentially. The doctor can observe 3D images cut in any plane by pushing a button of the digitizer and zooming with the keyboard. We evaluated our prototype system by observation of a mitral valve in motion.

  1. Three-dimensional laser microvision.

    PubMed

    Shimotahira, H; Iizuka, K; Chu, S C; Wah, C; Costen, F; Yoshikuni, Y

    2001-04-10

    A three-dimensional (3-D) optical imaging system offering high resolution in all three dimensions, requiring minimum manipulation and capable of real-time operation, is presented. The system derives its capabilities from use of the superstructure grating laser source in the implementation of a laser step frequency radar for depth information acquisition. A synthetic aperture radar technique was also used to further enhance its lateral resolution as well as extend the depth of focus. High-speed operation was made possible by a dual computer system consisting of a host and a remote microcomputer supported by a dual-channel Small Computer System Interface parallel data transfer system. The system is capable of operating near real time. The 3-D display of a tunneling diode, a microwave integrated circuit, and a see-through image taken by the system operating near real time are included. The depth resolution is 40 mum; lateral resolution with a synthetic aperture approach is a fraction of a micrometer and that without it is approximately 10 mum. PMID:18357177

  2. Three dimensional magnetic abacus memory

    NASA Astrophysics Data System (ADS)

    Zhang, Shilei; Zhang, Jingyan; Baker, Alexander A.; Wang, Shouguo; Yu, Guanghua; Hesjedal, Thorsten

    2014-08-01

    Stacking nonvolatile memory cells into a three-dimensional matrix represents a powerful solution for the future of magnetic memory. However, it is technologically challenging to access the data in the storage medium if large numbers of bits are stacked on top of each other. Here we introduce a new type of multilevel, nonvolatile magnetic memory concept, the magnetic abacus. Instead of storing information in individual magnetic layers, thereby having to read out each magnetic layer separately, the magnetic abacus adopts a new encoding scheme. It is inspired by the idea of second quantisation, dealing with the memory state of the entire stack simultaneously. Direct read operations are implemented by measuring the artificially engineered `quantised' Hall voltage, each representing a count of the spin-up and spin-down layers in the stack. This new memory system further allows for both flexible scaling of the system and fast communication among cells. The magnetic abacus provides a promising approach for future nonvolatile 3D magnetic random access memory.

  3. Three dimensional magnetic abacus memory.

    PubMed

    Zhang, ShiLei; Zhang, JingYan; Baker, Alexander A; Wang, ShouGuo; Yu, GuangHua; Hesjedal, Thorsten

    2014-08-22

    Stacking nonvolatile memory cells into a three-dimensional matrix represents a powerful solution for the future of magnetic memory. However, it is technologically challenging to access the data in the storage medium if large numbers of bits are stacked on top of each other. Here we introduce a new type of multilevel, nonvolatile magnetic memory concept, the magnetic abacus. Instead of storing information in individual magnetic layers, thereby having to read out each magnetic layer separately, the magnetic abacus adopts a new encoding scheme. It is inspired by the idea of second quantisation, dealing with the memory state of the entire stack simultaneously. Direct read operations are implemented by measuring the artificially engineered 'quantised' Hall voltage, each representing a count of the spin-up and spin-down layers in the stack. This new memory system further allows for both flexible scaling of the system and fast communication among cells. The magnetic abacus provides a promising approach for future nonvolatile 3D magnetic random access memory.

  4. Three dimensional magnetic abacus memory

    NASA Astrophysics Data System (ADS)

    Zhang, Shilei; Zhang, Jingyan; Baker, Alexander; Wang, Shouguo; Yu, Guanghua; Hesjedal, Thorsten

    2015-03-01

    Stacking nonvolatile memory cells into a three-dimensional matrix represents a powerful solution for the future of magnetic memory. However, it is technologically challenging to access the individual data in the storage medium if large numbers of bits are stacked on top of each other. Here we introduce a new type of multilevel, nonvolatile magnetic memory concept, the magnetic abacus. Instead of storing information in individual magnetic layers, thereby having to read out each magnetic layer separately, the magnetic abacus adopts a new encoding scheme which envisages a classical abacus with the beads operated by electron spins. It is inspired by the idea of second quantization, dealing with the memory state of the entire stack simultaneously. Direct read operations are implemented by measuring the artificially engineered `quantized' Hall voltage, representing a count of the spin-up and spin-down layers in the stack. This concept of `second quantization of memory' realizes the 3D memory architecture with superior reading and operation efficiency, thus is a promising approach for future nonvolatile magnetic random access memory.

  5. True three-dimensional camera

    NASA Astrophysics Data System (ADS)

    Kornreich, Philipp; Farell, Bart

    2013-01-01

    An imager that can measure the distance from each pixel to the point on the object that is in focus at the pixel is described. This is accomplished by short photo-conducting lightguides at each pixel. In the eye the rods and cones are the fiber-like lightguides. The device uses ambient light that is only coherent in spherical shell-shaped light packets of thickness of one coherence length. Modern semiconductor technology permits the construction of lightguides shorter than a coherence length of ambient light. Each of the frequency components of the broad band light arriving at a pixel has a phase proportional to the distance from an object point to its image pixel. Light frequency components in the packet arriving at a pixel through a convex lens add constructively only if the light comes from the object point in focus at this pixel. The light in packets from all other object points cancels. Thus the pixel receives light from one object point only. The lightguide has contacts along its length. The lightguide charge carriers are generated by the light patterns. These light patterns, and thus the photocurrent, shift in response to the phase of the input signal. Thus, the photocurrent is a function of the distance from the pixel to its object point. Applications include autonomous vehicle navigation and robotic vision. Another application is a crude teleportation system consisting of a camera and a three-dimensional printer at a remote location.

  6. Three-dimensional display technologies

    PubMed Central

    Geng, Jason

    2014-01-01

    The physical world around us is three-dimensional (3D), yet traditional display devices can show only two-dimensional (2D) flat images that lack depth (i.e., the third dimension) information. This fundamental restriction greatly limits our ability to perceive and to understand the complexity of real-world objects. Nearly 50% of the capability of the human brain is devoted to processing visual information [Human Anatomy & Physiology (Pearson, 2012)]. Flat images and 2D displays do not harness the brain’s power effectively. With rapid advances in the electronics, optics, laser, and photonics fields, true 3D display technologies are making their way into the marketplace. 3D movies, 3D TV, 3D mobile devices, and 3D games have increasingly demanded true 3D display with no eyeglasses (autostereoscopic). Therefore, it would be very beneficial to readers of this journal to have a systematic review of state-of-the-art 3D display technologies. PMID:25530827

  7. Three-Dimensional Schlieren Measurements

    NASA Astrophysics Data System (ADS)

    Sutherland, Bruce; Cochrane, Andrea

    2004-11-01

    Schlieren systems visualise disturbances that change the index of refraction of a fluid, for example due to temperature or salinity disturbances. `Synthetic schlieren' refers to a recent advance in which these disturbances are visualised with a digital camera and image-processing technology rather than the classical use of parabolic mirrors and a knife-edge. In a typical setup, light from an image of horizontal lines or dots passes almost horizontally through the test section of a fluid to a CCD camera. Refractive index disturbances distort the image and digital comparison of successive images reveals the plan-form structure and time evolution of the disturbances. If the disturbance is effectively two-dimensional, meaning that it is uniform across the line-of-sight of the camera, then its magnitude as well as its structure can measured through simple inversion of an algebraic equation. If the structure is axisymmetric with rotation-axis perpendicular to the line of sight, the magnitude of the disturbance can be measured through inversion of a non-singular square matrix. Here we report upon the extension of this work toward measuring the magnitude of a fully three-dimensional disturbance. This is done by analysing images from two perspectives through the test section and using inversion tomography techniques to reconstruct the disturbance field. The results are tested against theoretical predictions and experimental measurements.

  8. A Contralateral Esophagus-Sparing Technique to Limit Severe Esophagitis Associated With Concurrent High-Dose Radiation and Chemotherapy in Patients With Thoracic Malignancies

    SciTech Connect

    Al-Halabi, Hani; Paetzold, Peter; Sharp, Gregory C.; Olsen, Christine; Willers, Henning

    2015-07-15

    Purpose: Severe (Radiation Therapy Oncology Group [RTOG] grade 3 or greater) esophagitis generally occurs in 15% to 25% of non–small cell lung cancer (NSCLC) patients undergoing concurrent chemotherapy and radiation therapy (CCRT), which may result in treatment breaks that compromise local tumor control and pose a barrier to dose escalation. Here, we report a novel contralateral esophagus-sparing technique (CEST) that uses intensity modulated radiation therapy (IMRT) to reduce the incidence of severe esophagitis. Methods and Materials: We reviewed consecutive patients with thoracic malignancies undergoing curative CCRT in whom CEST was used. The esophageal wall contralateral (CE) to the tumor was contoured as an avoidance structure, and IMRT was used to guide a rapid dose falloff gradient beyond the target volume in close proximity to the esophagus. Esophagitis was recorded based on the RTOG acute toxicity grading system. Results: We identified 20 consecutive patients treated with CCRT of at least 63 Gy in whom there was gross tumor within 1 cm of the esophagus. The median radiation dose was 70.2 Gy (range, 63-72.15 Gy). In all patients, ≥99% of the planning and internal target volumes was covered by ≥90% and 100% of prescription dose, respectively. Strikingly, no patient experienced grade ≥3 esophagitis (95% confidence limits, 0%-16%) despite the high total doses delivered. The median maximum dose, V45, and V55 of the CE were 60.7 Gy, 2.1 cc, and 0.4 cc, respectively, indicating effective esophagus cross-section sparing by CEST. Conclusion: We report a simple yet effective method to avoid exposing the entire esophagus cross-section to high doses. By using proposed CE dose constraints of V45 <2.5 cc and V55 <0.5 cc, CEST may improve the esophagus toxicity profile in thoracic cancer patients receiving CCRT even at doses above the standard 60- to 63-Gy levels. Prospective testing of CEST is warranted.

  9. Three dimensional structures of solar active regions

    NASA Technical Reports Server (NTRS)

    Kundu, M. R.

    1986-01-01

    Three dimensional structure of an active region is determined from observations with the Very Large Array (VLA) at 2, 6, and 20 cm. This region exhibits a single magnetic loop of length approx. 10 to the 10th power cm. The 2 cm radiation is mostly thermal bremsstrahlung and originates from the footpoints of the loop. The 6 and 20 cm radiation is dominated by the low harmonic gyroresonance radiation and originates from the upper portion of the legs or the top of the loop. The loop broadens toward the apex. The top of the loop is not found to be the hottest point, but two temperature maxima on either side of the loop apex are observed, which is consistent with the model proposed for long loops. From 2 and 6 cm observations it can be concluded that the electron density and temperature cannot be uniform in a plane perpendicular to the axis of the loop; the density should decrease away from the axis of the loop.

  10. Impact of Dose to the Bladder Trigone on Long-Term Urinary Function After High-Dose Intensity Modulated Radiation Therapy for Localized Prostate Cancer

    SciTech Connect

    Ghadjar, Pirus; Zelefsky, Michael J.; Spratt, Daniel E.; Munck af Rosenschöld, Per; Oh, Jung Hun; Hunt, Margie; Kollmeier, Marisa; Happersett, Laura; Yorke, Ellen; Deasy, Joseph O.; Jackson, Andrew

    2014-02-01

    Purpose: To determine the potential association between genitourinary (GU) toxicity and planning dose–volume parameters for GU pelvic structures after high-dose intensity modulated radiation therapy in localized prostate cancer patients. Methods and Materials: A total of 268 patients who underwent intensity modulated radiation therapy to a prescribed dose of 86.4 Gy in 48 fractions during June 2004-December 2008 were evaluated with the International Prostate Symptom Score (IPSS) questionnaire. Dose–volume histograms of the whole bladder, bladder wall, urethra, and bladder trigone were analyzed. The primary endpoint for GU toxicity was an IPSS sum increase ≥10 points over baseline. Univariate and multivariate analyses were done by the Kaplan-Meier method and Cox proportional hazard models, respectively. Results: Median follow-up was 5 years (range, 3-7.7 years). Thirty-nine patients experienced an IPSS sum increase ≥10 during follow-up; 84% remained event free at 5 years. After univariate analysis, lower baseline IPSS sum (P=.006), the V90 of the trigone (P=.006), and the maximal dose to the trigone (P=.003) were significantly associated with an IPSS sum increase ≥10. After multivariate analysis, lower baseline IPSS sum (P=.009) and increased maximal dose to the trigone (P=.005) remained significantly associated. Seventy-two patients had both a lower baseline IPSS sum and a higher maximal dose to the trigone and were defined as high risk, and 68 patients had both a higher baseline IPSS sum and a lower maximal dose to the trigone and were defined as low risk for development of an IPSS sum increase ≥10. Twenty-one of 72 high-risk patients (29%) and 5 of 68 low-risk patients (7%) experienced an IPSS sum increase ≥10 (P=.001; odds ratio 5.19). Conclusions: The application of hot spots to the bladder trigone was significantly associated with relevant changes in IPSS during follow-up. Reduction of radiation dose to the lower bladder and specifically the

  11. High-Dose and Extended-Field Intensity Modulated Radiation Therapy for Early-Stage NK/T-Cell Lymphoma of Waldeyer's Ring: Dosimetric Analysis and Clinical Outcome

    SciTech Connect

    Bi, Xi-Wen; Li, Ye-Xiong Fang, Hui; Jin, Jing; Wang, Wei-Hu; Wang, Shu-Lian; Liu, Yue-Ping; Song, Yong-Wen; Ren, Hua; Dai, Jian-Rong

    2013-12-01

    Purpose: To assess the dosimetric benefit, treatment outcome, and toxicity of high-dose and extended-field intensity modulated radiation therapy (IMRT) in patients with early-stage NK/T-cell lymphoma of Waldeyer's ring (WR-NKTCL). Methods and Materials: Thirty patients with early-stage WR-NKTCL who received extended-field IMRT were retrospectively reviewed. The prescribed dose was 50 Gy to the primary involved regions and positive cervical lymph nodes (planning target volume requiring radical irradiation [PTV{sub 50}]) and 40 Gy to the negative cervical nodes (PTV{sub 40}). Dosimetric parameters for the target volume and critical normal structures were evaluated. Locoregional control (LRC), overall survival (OS), and progression-free survival (PFS) were calculated using the Kaplan-Meier method. Results: The median mean doses to the PTV{sub 50} and PTV{sub 40} were 53.2 Gy and 43.0 Gy, respectively. Only 1.4% of the PTV{sub 50} and 0.9% of the PTV{sub 40} received less than 95% of the prescribed dose, indicating excellent target coverage. The average mean doses to the left and right parotid glands were 27.7 and 28.4 Gy, respectively. The 2-year OS, PFS, and LRC rates were 71.2%, 57.4%, and 87.8%. Most acute toxicities were grade 1 to 2, except for grade ≥3 dysphagia and mucositis. The most common late toxicity was grade 1-2 xerostomia, and no patient developed any ≥grade 3 late toxicities. A correlation between the mean dose to the parotid glands and the degree of late xerostomia was observed. Conclusions: IMRT achieves excellent target coverage and dose conformity, as well as favorable survival and locoregional control rates with acceptable toxicities in patients with WR-NKTCL.

  12. Single-Fraction High-Dose-Rate Brachytherapy and Hypofractionated External Beam Radiation Therapy in the Treatment of Intermediate-Risk Prostate Cancer - Long Term Results

    SciTech Connect

    Cury, Fabio L.; Duclos, Marie; Aprikian, Armen; Patrocinio, Horacio; Kassouf, Wassim; Shenouda, George; Faria, Sergio; David, Marc; Souhami, Luis

    2012-03-15

    Purpose: We present the long-term results of a cohort of patients with intermediate-risk prostate cancer (PC) treated with single-fraction high-dose-rate brachytherapy (HDRB) combined with hypofractionated external beam radiation therapy (HypoRT). Methods and Materials: Patients were treated exclusively with HDRB and HypoRT. HDRB delivered a dose of 10 Gy to the prostate surface and HypoRT consisted of 50 Gy delivered in 20 daily fractions. The first 121 consecutive patients with a minimum of 2 years posttreatment follow-up were assessed for toxicity and disease control. Results: The median follow-up was 65.2 months. No acute Grade III or higher toxicity was seen. Late Grade II gastrointestinal toxicity was seen in 9 patients (7.4%) and Grade III in 2 (1.6%). Late Grade III genitourinary toxicity was seen in 2 patients (1.6%). After a 24-month follow-up, a rebiopsy was offered to the first 58 consecutively treated patients, and 44 patients agreed with the procedure. Negative biopsies were found in 40 patients (91%). The 5-year biochemical relapse-free survival rate was 90.7% (95% CI, 84.5-96.9%), with 13 patients presenting biochemical failure. Among them, 9 were diagnosed with distant metastasis. Prostate cancer-specific and overall survival rates at 5 years were 100% and 98.8% (95% CI, 96.4-100%), respectively. Conclusion: The combination of HDRB and HypoRT is well tolerated, with acceptable toxicity rates. Furthermore, results from rebiopsies revealed an encouraging rate of local control. These results confirm that the use of conformal RT techniques, adapted to specific biological tumor characteristics, have the potential to improve the therapeutic ratio in intermediate-risk PC patients.

  13. Three-dimensional far-infrared imaging by using perspective thermal images

    NASA Astrophysics Data System (ADS)

    Barada, Daisuke

    2016-06-01

    This paper proposes a method to obtain three-dimensional thermal radiation distribution. In the method, multiple oblique projection thermal images are obtained by moving a target object and three-dimensional thermal radiation distribution is reconstructed based on projection-slice theorem. In experiment, incandescent light bulbs or a plant is used as a sample object. The three-dimensional position measured is coincided with actual position and the principle is experimentally verified.

  14. Comparison study of the partial-breast irradiation techniques: Dosimetric analysis of three-dimensional conformal radiation therapy, electron beam therapy, and helical tomotherapy depending on various tumor locations

    SciTech Connect

    Kim, Min-Joo; Park, So-Hyun; Son, Seok-Hyun; Cheon, Keum-Seong; Choi, Byung-Ock; Suh, Tae-Suk

    2013-10-01

    The partial-breast irradiation (PBI) technique, an alternative to whole-breast irradiation, is a beam delivery method that uses a limited range of treatment volume. The present study was designed to determine the optimal PBI treatment modalities for 8 different tumor locations. Treatment planning was performed on computed tomography (CT) data sets of 6 patients who had received lumpectomy treatments. Tumor locations were classified into 8 subsections according to breast quadrant and depth. Three-dimensional conformal radiation therapy (3D-CRT), electron beam therapy (ET), and helical tomotherapy (H-TOMO) were utilized to evaluate the dosimetric effect for each tumor location. Conformation number (CN), radical dose homogeneity index (rDHI), and dose delivered to healthy tissue were estimated. The Kruskal-Wallis, Mann-Whitney U, and Bonferroni tests were used for statistical analysis. The ET approach showed good sparing effects and acceptable target coverage for the lower inner quadrant—superficial (LIQ-S) and lower inner quadrant—deep (LIQ-D) locations. The H-TOMO method was the least effective technique as no evaluation index achieved superiority for all tumor locations except CN. The ET method is advisable for treating LIQ-S and LIQ-D tumors, as opposed to 3D-CRT or H-TOMO, because of acceptable target coverage and much lower dose applied to surrounding tissue.

  15. View Factor Calculation for Three-Dimensional Geometries.

    1989-06-20

    Version 00 MCVIEW calculates the radiation geometric view factor between surfaces for three dimensional geometries with and without interposed third surface obstructions. It was developed to calculate view factors for input data to heat transfer analysis programs such as SCA-03/TRUMP, SCA-01/HEATING-5 and PSR-199/HEATING-6.

  16. Dose painting to treat single-lobe prostate cancer with hypofractionated high-dose radiation using targeted external beam radiation: Is it feasible?

    PubMed

    Amini, Arya; Westerly, David C; Waxweiler, Timothy V; Ryan, Nicole; Raben, David

    2015-01-01

    Targeted focal therapy strategies for treating single-lobe prostate cancer are under investigation. In this planning study, we investigate the feasibility of treating a portion of the prostate to full-dose external beam radiation with reduced dose to the opposite lobe, compared with full-dose radiation delivered to the entire gland using hypofractionated radiation. For 10 consecutive patients with low- to intermediate-risk prostate cancer, 2 hypofractionated, single-arc volumetric-modulated arc therapy (VMAT) plans were designed. The first plan (standard hypofractionation regimen [STD]) included the entire prostate gland, treated to 70 Gy delivered in 28 fractions. The second dose painting plan (DP) encompassed the involved lobe treated to 70 Gy delivered in 28 fractions, whereas the opposing, uninvolved lobe received 50.4 Gy in 28 fractions. Mean dose to the opposing neurovascular bundle (NVB) was considerably lower for DP vs STD, with a mean dose of 53.9 vs 72.3 Gy (p < 0.001). Mean penile bulb dose was 18.6 Gy for DP vs 19.2 Gy for STD (p = 0.880). Mean rectal dose was 21.0 Gy for DP vs 22.8 Gy for STD (p = 0.356). Rectum V70 (the volume receiving ≥70 Gy) was 2.01% for DP vs 2.74% for STD (p = 0.328). Bladder V70 was 1.69% for DP vs 2.78% for STD (p = 0.232). Planning target volume (PTV) maximum dose points were 76.5 and 76.3 Gy for DP and STD, respectively (p = 0.760). This study demonstrates the feasibility of using VMAT for partial-lobe prostate radiation in patients with prostate cancer involving 1 lobe. Partial-lobe prostate plans appeared to spare adjacent critical structures including the opposite NVB.

  17. Dose painting to treat single-lobe prostate cancer with hypofractionated high-dose radiation using targeted external beam radiation: Is it feasible?

    SciTech Connect

    Amini, Arya; Westerly, David C.; Waxweiler, Timothy V.; Ryan, Nicole; Raben, David

    2015-10-01

    Targeted focal therapy strategies for treating single-lobe prostate cancer are under investigation. In this planning study, we investigate the feasibility of treating a portion of the prostate to full-dose external beam radiation with reduced dose to the opposite lobe, compared with full-dose radiation delivered to the entire gland using hypofractionated radiation. For 10 consecutive patients with low- to intermediate-risk prostate cancer, 2 hypofractionated, single-arc volumetric-modulated arc therapy (VMAT) plans were designed. The first plan (standard hypofractionation regimen [STD]) included the entire prostate gland, treated to 70 Gy delivered in 28 fractions. The second dose painting plan (DP) encompassed the involved lobe treated to 70 Gy delivered in 28 fractions, whereas the opposing, uninvolved lobe received 50.4 Gy in 28 fractions. Mean dose to the opposing neurovascular bundle (NVB) was considerably lower for DP vs STD, with a mean dose of 53.9 vs 72.3 Gy (p < 0.001). Mean penile bulb dose was 18.6 Gy for DP vs 19.2 Gy for STD (p = 0.880). Mean rectal dose was 21.0 Gy for DP vs 22.8 Gy for STD (p = 0.356). Rectum V{sub 70} (the volume receiving ≥70 Gy) was 2.01% for DP vs 2.74% for STD (p = 0.328). Bladder V{sub 70} was 1.69% for DP vs 2.78% for STD (p = 0.232). Planning target volume (PTV) maximum dose points were 76.5 and 76.3 Gy for DP and STD, respectively (p = 0.760). This study demonstrates the feasibility of using VMAT for partial-lobe prostate radiation in patients with prostate cancer involving 1 lobe. Partial-lobe prostate plans appeared to spare adjacent critical structures including the opposite NVB.

  18. Indirect Tumor Cell Death After High-Dose Hypofractionated Irradiation: Implications for Stereotactic Body Radiation Therapy and Stereotactic Radiation Surgery

    SciTech Connect

    Song, Chang W.; Lee, Yoon-Jin; Griffin, Robert J.; Park, Inhwan; Koonce, Nathan A.; Hui, Susanta; Kim, Mi-Sook; Dusenbery, Kathryn E.; Sperduto, Paul W.; Cho, L. Chinsoo

    2015-09-01

    Purpose: The purpose of this study was to reveal the biological mechanisms underlying stereotactic body radiation therapy (SBRT) and stereotactic radiation surgery (SRS). Methods and Materials: FSaII fibrosarcomas grown subcutaneously in the hind limbs of C3H mice were irradiated with 10 to 30 Gy of X rays in a single fraction, and the clonogenic cell survival was determined with in vivo–in vitro excision assay immediately or 2 to 5 days after irradiation. The effects of radiation on the intratumor microenvironment were studied using immunohistochemical methods. Results: After cells were irradiated with 15 or 20 Gy, cell survival in FSaII tumors declined for 2 to 3 days and began to recover thereafter in some but not all tumors. After irradiation with 30 Gy, cell survival declined continuously for 5 days. Cell survival in some tumors 5 days after 20 to 30 Gy irradiation was 2 to 3 logs less than that immediately after irradiation. Irradiation with 20 Gy markedly reduced blood perfusion, upregulated HIF-1α, and increased carbonic anhydrase-9 expression, indicating that irradiation increased tumor hypoxia. In addition, expression of VEGF also increased in the tumor tissue after 20 Gy irradiation, probably due to the increase in HIF-1α activity. Conclusions: Irradiation of FSaII tumors with 15 to 30 Gy in a single dose caused dose-dependent secondary cell death, most likely by causing vascular damage accompanied by deterioration of intratumor microenvironment. Such indirect tumor cell death may play a crucial role in the control of human tumors with SBRT and SRS.

  19. Is intensity-modulated radiotherapy better than conventional radiation treatment and three-dimensional conformal radiotherapy for mediastinal masses in patients with Hodgkin's disease, and is there a role for beam orientation optimization and dose constraints assigned to virtual volumes?

    SciTech Connect

    Girinsky, Theodore . E-mail: girinsky@igr.fr; Pichenot, Charlotte; Beaudre, Anne; Ghalibafian, Mithra; Lefkopoulos, Dimitri

    2006-01-01

    Purpose: To evaluate the role of beam orientation optimization and the role of virtual volumes (VVs) aimed at protecting adjacent organs at risk (OARs), and to compare various intensity-modulated radiotherapy (IMRT) setups with conventional treatment with anterior and posterior fields and three-dimensional conformal radiotherapy (3D-CRT). Methods and Materials: Patients with mediastinal masses in Hodgkin's disease were treated with combined modality therapy (three to six cycles of adriamycin, bleomycin, vinblastine, and dacarbazine [ABVD] before radiation treatment). Contouring and treatment planning were performed with Somavision and CadPlan Helios (Varian Systems, Palo Alto, CA). The gross tumor volume was determined according to the prechemotherapy length and the postchemotherapy width of the mediastinal tumor mass. A 10-mm isotropic margin was added for the planning target volume (PTV). Because dose constraints assigned to OARs led to unsatisfactory PTV coverage, VVs were designed for each patient to protect adjacent OARs. The prescribed dose was 40 Gy to the PTV, delivered according to guidelines from International Commission on Radiation Units and Measurements Report No. 50. Five different IMRT treatment plans were compared with conventional treatment and 3D-CRT. Results: Beam orientation was important with respect to the amount of irradiated normal tissues. The best compromise in terms of PTV coverage and protection of normal tissues was obtained with five equally spaced beams (5FEQ IMRT plan) using dose constraints assigned to VVs. When IMRT treatment plans were compared with conventional treatment and 3D-CRT, dose conformation with IMRT was significantly better, with greater protection of the heart, coronary arteries, esophagus, and spinal cord. The lungs and breasts in women received a slightly higher radiation dose with IMRT compared with conventional treatments. The greater volume of normal tissue receiving low radiation doses could be a cause for

  20. Three Dimensional Illustrating--Three-Dimensional Vision and Deception of Sensibility

    ERIC Educational Resources Information Center

    Szállassy, Noémi; Gánóczy, Anita; Kriska, György

    2009-01-01

    The wide-spread digital photography and computer use gave the opportunity for everyone to make three-dimensional pictures and to make them public. The new opportunities with three-dimensional techniques give chance for the birth of new artistic photographs. We present in detail the biological roots of three-dimensional visualization, the phenomena…

  1. A comprehensive dosimetric study of pancreatic cancer treatment using three-dimensional conformal radiation therapy (3DCRT), intensity-modulated radiation therapy (IMRT), volumetric-modulated radiation therapy (VMAT), and passive-scattering and modulated-scanning proton therapy (PT)

    SciTech Connect

    Ding, Xuanfeng; Dionisi, Francesco; Tang, Shikui; Ingram, Mark; Hung, Chun-Yu; Prionas, Evangelos; Lichtenwalner, Phil; Butterwick, Ian; Zhai, Huifang; Yin, Lingshu; Lin, Haibo; Kassaee, Alireza; Avery, Stephen

    2014-07-01

    With traditional photon therapy to treat large postoperative pancreatic target volume, it often leads to poor tolerance of the therapy delivered and may contribute to interrupted treatment course. This study was performed to evaluate the potential advantage of using passive-scattering (PS) and modulated-scanning (MS) proton therapy (PT) to reduce normal tissue exposure in postoperative pancreatic cancer treatment. A total of 11 patients with postoperative pancreatic cancer who had been previously treated with PS PT in University of Pennsylvania Roberts Proton Therapy Center from 2010 to 2013 were identified. The clinical target volume (CTV) includes the pancreatic tumor bed as well as the adjacent high-risk nodal areas. Internal (iCTV) was generated from 4-dimensional (4D) computed tomography (CT), taking into account target motion from breathing cycle. Three-field and 4-field 3D conformal radiation therapy (3DCRT), 5-field intensity-modulated radiation therapy, 2-arc volumetric-modulated radiation therapy, and 2-field PS and MS PT were created on the patients’ average CT. All the plans delivered 50.4 Gy to the planning target volume (PTV). Overall, 98% of PTV was covered by 95% of the prescription dose and 99% of iCTV received 98% prescription dose. The results show that all the proton plans offer significant lower doses to the left kidney (mean and V{sub 18} {sub Gy}), stomach (mean and V{sub 20} {sub Gy}), and cord (maximum dose) compared with all the photon plans, except 3-field 3DCRT in cord maximum dose. In addition, MS PT also provides lower doses to the right kidney (mean and V{sub 18} {sub Gy}), liver (mean dose), total bowel (V{sub 20} {sub Gy} and mean dose), and small bowel (V{sub 15} {sub Gy} absolute volume ratio) compared with all the photon plans and PS PT. The dosimetric advantage of PT points to the possibility of treating tumor bed and comprehensive nodal areas while providing a more tolerable treatment course that could be used for dose

  2. Initial Efficacy Results of RTOG 0319: Three-Dimensional Conformal Radiation Therapy (3D-CRT) Confined to the Region of the Lumpectomy Cavity for Stage I/ II Breast Carcinoma

    SciTech Connect

    Vicini, Frank; Winter, Kathryn; Wong, John

    2010-07-15

    Purpose: This prospective study (Radiation Therapy Oncology Group 0319) examines the use of three-dimensional conformal external beam radiotherapy (3D-CRT) to deliver accelerated partial breast irradiation (APBI). Initial data on efficacy and toxicity are presented. Methods and Materials: Patients with Stage I or II breast cancer with lesions {<=}3 cm, negative margins and with {<=}3 positive nodes were eligible. The 3D-CRT was 38.5 Gy in 3.85 Gy/fraction delivered 2x/day. Ipsilateral breast, ipsilateral nodal, contralateral breast, and distant failure (IBF, INF, CBF, DF) were estimated using the cumulative incidence method. Mastectomy-free, disease-free, and overall survival (MFS, DFS, OS) were recorded. The National Cancer Institute Common Terminology Criteria for Adverse Events, version 3, was used to grade acute and late toxicity. Results: Fifty-eight patients were entered and 52 patients are eligible and evaluable for efficacy. The median age of patients was 61 years with the following characteristics: 46% tumor size <1 cm; 87% invasive ductal histology; 94% American Joint Committee on Cancer Stage I; 65% postmenopausal; 83% no chemotherapy; and 71% with no hormone therapy. Median follow-up is 4.5 years (1.7-4.8). Four-year estimates (95% CI) of efficacy are: IBF 6% (0-12%) [4% within field (0-9%)]; INF 2% (0-6%); CBF 0%; DF 8% (0-15%); MFS 90% (78-96%); DFS 84% (71-92%); and OS 96% (85-99%). Only two (4%) Grade 3 toxicities were observed. Conclusions: Initial efficacy and toxicity using 3D-CRT to deliver APBI appears comparable to other experiences with similar follow-up. However, additional patients, further follow-up, and mature Phase III data are needed to evaluate the extent of application, limitations, and value of this particular form of APBI.

  3. Three-dimensional laser window formation

    NASA Technical Reports Server (NTRS)

    Verhoff, Vincent G.

    1992-01-01

    The NASA Lewis Research Center has developed and implemented a unique process for forming flawless three-dimensional laser windows. These windows represent a major part of specialized, nonintrusive laser data acquisition systems used in a variety of compressor and turbine research test facilities. This report discusses in detail the aspects of three-dimensional laser window formation. It focuses on the unique methodology and the peculiarities associated with the formation of these windows. Included in this discussion are the design criteria, bonding mediums, and evaluation testing for three-dimensional laser windows.

  4. Preliminary Toxicity Analysis of 3-Dimensional Conformal Radiation Therapy Versus Intensity Modulated Radiation Therapy on the High-Dose Arm of the Radiation Therapy Oncology Group 0126 Prostate Cancer Trial

    SciTech Connect

    Michalski, Jeff M.; Yan, Yan; Watkins-Bruner, Deborah; Bosch, Walter R.; Winter, Kathryn; Galvin, James M.; Bahary, Jean-Paul; Morton, Gerard C.; Parliament, Matthew B.; Sandler, Howard M.

    2013-12-01

    Purpose: To give a preliminary report of clinical and treatment factors associated with toxicity in men receiving high-dose radiation therapy (RT) on a phase 3 dose-escalation trial. Methods and Materials: The trial was initiated with 3-dimensional conformal RT (3D-CRT) and amended after 1 year to allow intensity modulated RT (IMRT). Patients treated with 3D-CRT received 55.8 Gy to a planning target volume that included the prostate and seminal vesicles, then 23.4 Gy to prostate only. The IMRT patients were treated to the prostate and proximal seminal vesicles to 79.2 Gy. Common Toxicity Criteria, version 2.0, and Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer late morbidity scores were used for acute and late effects. Results: Of 763 patients randomized to the 79.2-Gy arm of Radiation Therapy Oncology Group 0126 protocol, 748 were eligible and evaluable: 491 and 257 were treated with 3D-CRT and IMRT, respectively. For both bladder and rectum, the volumes receiving 65, 70, and 75 Gy were significantly lower with IMRT (all P<.0001). For grade (G) 2+ acute gastrointestinal/genitourinary (GI/GU) toxicity, both univariate and multivariate analyses showed a statistically significant decrease in G2+ acute collective GI/GU toxicity for IMRT. There were no significant differences with 3D-CRT or IMRT for acute or late G2+ or 3+ GU toxicities. Univariate analysis showed a statistically significant decrease in late G2+ GI toxicity for IMRT (P=.039). On multivariate analysis, IMRT showed a 26% reduction in G2+ late GI toxicity (P=.099). Acute G2+ toxicity was associated with late G3+ toxicity (P=.005). With dose–volume histogram data in the multivariate analysis, RT modality was not significant, whereas white race (P=.001) and rectal V70 ≥15% were associated with G2+ rectal toxicity (P=.034). Conclusions: Intensity modulated RT is associated with a significant reduction in acute G2+ GI/GU toxicity. There is a trend for a

  5. Three Dimensional Optic Tissue Culture and Process

    NASA Technical Reports Server (NTRS)

    OConnor, Kim C. (Inventor); Spaulding, Glenn F. (Inventor); Goodwin, Thomas J. (Inventor); Aten, Laurie A. (Inventor); Francis, Karen M. (Inventor); Caldwell, Delmar R. (Inventor); Prewett, Tacey L. (Inventor); Fitzgerald, Wendy S. (Inventor)

    1999-01-01

    A process for artificially producing three-dimensional optic tissue has been developed. The optic cells are cultured in a bioireactor at low shear conditions. The tissue forms as normal, functional tissue grows with tissue organization and extracellular matrix formation.

  6. Three dimensional optic tissue culture and process

    NASA Technical Reports Server (NTRS)

    Spaulding, Glenn F. (Inventor); Prewett, Tacey L. (Inventor); Goodwin, Thomas J. (Inventor); Francis, Karen M. (Inventor); Cardwell, Delmar R. (Inventor); Oconnor, Kim (Inventor); Fitzgerald, Wendy S. (Inventor); Aten, Laurie A. (Inventor)

    1994-01-01

    A process for artificially producing three-dimensional optic tissue has been developed. The optic cells are cultured in a bioreactor at low shear conditions. The tissue forms normal, functional tissue organization and extracellular matrix.

  7. Three-dimensional reconstruction of Haversian systems in human cortical bone using synchrotron radiation-based micro-CT: morphology and quantification of branching and transverse connections across age.

    PubMed

    Maggiano, Isabel S; Maggiano, Corey M; Clement, John G; Thomas, C David L; Carter, Yasmin; Cooper, David M L

    2016-05-01

    This study uses synchrotron radiation-based micro-computed tomography (CT) scans to reconstruct three-dimensional networks of Haversian systems in human cortical bone in order to observe and analyse interconnectivity of Haversian systems and the development of total Haversian networks across different ages. A better knowledge of how Haversian systems interact with each other is essential to improve understanding of remodeling mechanisms and bone maintenance; however, previous methodological approaches (e.g. serial sections) did not reveal enough detail to follow the specific morphology of Haversian branching, for example. Accordingly, the aim of the present study was to identify the morphological diversity of branching patterns and transverse connections, and to understand how they change with age. Two types of branching morphologies were identified: lateral branching, resulting in small osteon branches bifurcating off of larger Haversian canals; and dichotomous branching, the formation of two new osteonal branches from one. The reconstructions in this study also suggest that Haversian systems frequently target previously existing systems as a path for their course, resulting in a cross-sectional morphology frequently referred to as 'type II osteons'. Transverse connections were diverse in their course from linear to oblique to curvy. Quantitative assessment of age-related trends indicates that while in younger human individuals transverse connections were most common, in older individuals more evidence of connections resulting from Haversian systems growing inside previously existing systems was found. Despite these changes in morphological characteristics, a relatively constant degree of overall interconnectivity is maintained throughout life. Altogether, the present study reveals important details about Haversian systems and their relation to each other that can be used towards a better understanding of cortical bone remodeling as well as a more accurate

  8. Three-Dimensional Icosahedral Phase Field Quasicrystal

    NASA Astrophysics Data System (ADS)

    Subramanian, P.; Archer, A. J.; Knobloch, E.; Rucklidge, A. M.

    2016-08-01

    We investigate the formation and stability of icosahedral quasicrystalline structures using a dynamic phase field crystal model. Nonlinear interactions between density waves at two length scales stabilize three-dimensional quasicrystals. We determine the phase diagram and parameter values required for the quasicrystal to be the global minimum free energy state. We demonstrate that traits that promote the formation of two-dimensional quasicrystals are extant in three dimensions, and highlight the characteristics required for three-dimensional soft matter quasicrystal formation.

  9. {sup 18}F-Choline Positron Emission Tomography/Computed Tomography–Driven High-Dose Salvage Radiation Therapy in Patients With Biochemical Progression After Radical Prostatectomy: Feasibility Study in 60 Patients

    SciTech Connect

    D'Angelillo, Rolando M.; Sciuto, Rosa; Ramella, Sara; Papalia, Rocco; Jereczek-Fossa, Barbara A.; Trodella, Luca E.; Fiore, Michele; Gallucci, Michele; Maini, Carlo L.; Trodella, Lucio

    2014-10-01

    Purpose: To retrospectively review data of a cohort of patients with biochemical progression after radical prostatectomy, treated according to a uniform institutional treatment policy, to evaluate toxicity and feasibility of high-dose salvage radiation therapy (80 Gy). Methods and Materials: Data on 60 patients with biochemical progression after radical prostatectomy between January 2009 and September 2011 were reviewed. The median value of prostate-specific antigen before radiation therapy was 0.9 ng/mL. All patients at time of diagnosis of biochemical recurrence underwent dynamic {sup 18}F-choline positron emission tomography/computed tomography (PET/CT), which revealed in all cases a local recurrence. High-dose salvage radiation therapy was delivered up to total dose of 80 Gy to 18F-choline PET/CT-positive area. Toxicity was recorded according to the Common Terminology Criteria for Adverse Events, version 3.0, scale. Results: Treatment was generally well tolerated: 54 patients (90%) completed salvage radiation therapy without any interruption. Gastrointestinal grade ≥2 acute toxicity was recorded in 6 patients (10%), whereas no patient experienced a grade ≥2 genitourinary toxicity. No grade 4 acute toxicity events were recorded. Only 1 patient (1.7%) experienced a grade 2 gastrointestinal late toxicity. With a mean follow-up of 31.2 months, 46 of 60 patients (76.6%) were free of recurrence. The 3-year biochemical progression-free survival rate was 72.5%. Conclusions: At early follow-up, {sup 18}F-choline PET/CT-driven high-dose salvage radiation therapy seems to be feasible and well tolerated, with a low rate of toxicity.

  10. A method for three-dimensional prostate imaging using transrectal ultrasound.

    PubMed

    Richard, W D; Grimmell, C K; Bedigian, K; Frank, K J

    1993-01-01

    This paper describes a method for forming three-dimensional images of the prostate using transrectal ultrasound. This method extracts three-dimensional images of the prostate from sets of two-dimensional ultrasound images obtained via a special-purpose transrectal ultrasound probe. Each two-dimensional image is segmented and the results used to form a three-dimensional image of the prostate. A method for segmenting two-dimensional images of the prostate based on the Laplacian-of-Gaussian edge operator is described. The three-dimensional imaging method described provides a new, noninvasive method for monitoring gland pathology during radiation therapy. PMID:8518996

  11. Vision in our three-dimensional world

    PubMed Central

    2016-01-01

    Many aspects of our perceptual experience are dominated by the fact that our two eyes point forward. Whilst the location of our eyes leaves the environment behind our head inaccessible to vision, co-ordinated use of our two eyes gives us direct access to the three-dimensional structure of the scene in front of us, through the mechanism of stereoscopic vision. Scientific understanding of the different brain regions involved in stereoscopic vision and three-dimensional spatial cognition is changing rapidly, with consequent influences on fields as diverse as clinical practice in ophthalmology and the technology of virtual reality devices. This article is part of the themed issue ‘Vision in our three-dimensional world’. PMID:27269595

  12. Three-dimensional separation and reattachment

    NASA Technical Reports Server (NTRS)

    Peake, D. J.; Tobak, M.

    1982-01-01

    The separation of three dimensional turbulent boundary layers from the lee of flight vehicles at high angles of attack is investigated. The separation results in dominant, large scale, coiled vortex motions that pass along the body in the general direction of the free stream. In all cases of three dimensional flow separation and reattachment, the assumption of continuous vector fields of skin friction lines and external flow streamlines, coupled with simple laws of topology, provides a flow grammar whose elemental constituents are the singular points: the nodes, spiral nodes (foci), and saddles. The phenomenon of three dimensional separation may be constrained as either a local or a global event, depending on whether the skin friction line that becomes a line of separation originates at a node or a saddle point.

  13. Topology of three-dimensional separated flows

    NASA Technical Reports Server (NTRS)

    Tobak, M.; Peake, D. J.

    1981-01-01

    Based on the hypothesis that patterns of skin-friction lines and external streamlines reflect the properties of continuous vector fields, topology rules define a small number of singular points (nodes, saddle points, and foci) that characterize the patterns on the surface and on particular projections of the flow (e.g., the crossflow plane). The restricted number of singular points and the rules that they obey are considered as an organizing principle whose finite number of elements can be combined in various ways to connect together the properties common to all steady three dimensional viscous flows. Introduction of a distinction between local and global properties of the flow resolves an ambiguity in the proper definition of a three dimensional separated flow. Adoption of the notions of topological structure, structural stability, and bifurcation provides a framework to describe how three dimensional separated flows originate and succeed each other as the relevant parameters of the problem are varied.

  14. Three-Dimensional Robotic Vision System

    NASA Technical Reports Server (NTRS)

    Nguyen, Thinh V.

    1989-01-01

    Stereoscopy and motion provide clues to outlines of objects. Digital image-processing system acts as "intelligent" automatic machine-vision system by processing views from stereoscopic television cameras into three-dimensional coordinates of moving object in view. Epipolar-line technique used to find corresponding points in stereoscopic views. Robotic vision system analyzes views from two television cameras to detect rigid three-dimensional objects and reconstruct numerically in terms of coordinates of corner points. Stereoscopy and effects of motion on two images complement each other in providing image-analyzing subsystem with clues to natures and locations of principal features.

  15. Three-Dimensional Extended Bargmann Supergravity

    NASA Astrophysics Data System (ADS)

    Bergshoeff, Eric; Rosseel, Jan

    2016-06-01

    We show that three-dimensional general relativity, augmented with two vector fields, allows for a nonrelativistic limit, different from the standard limit leading to Newtonian gravity, that results in a well-defined action which is of the Chern-Simons type. We show that this three-dimensional "extended Bargmann gravity," after coupling to matter, leads to equations of motion allowing a wider class of background geometries than the ones that one encounters in Newtonian gravity. We give the supersymmetric generalization of these results and point out an important application in the context of calculating partition functions of nonrelativistic field theories using localization techniques.

  16. Three-Dimensional Extended Bargmann Supergravity.

    PubMed

    Bergshoeff, Eric; Rosseel, Jan

    2016-06-24

    We show that three-dimensional general relativity, augmented with two vector fields, allows for a nonrelativistic limit, different from the standard limit leading to Newtonian gravity, that results in a well-defined action which is of the Chern-Simons type. We show that this three-dimensional "extended Bargmann gravity," after coupling to matter, leads to equations of motion allowing a wider class of background geometries than the ones that one encounters in Newtonian gravity. We give the supersymmetric generalization of these results and point out an important application in the context of calculating partition functions of nonrelativistic field theories using localization techniques. PMID:27391712

  17. Three-Dimensional Icosahedral Phase Field Quasicrystal.

    PubMed

    Subramanian, P; Archer, A J; Knobloch, E; Rucklidge, A M

    2016-08-12

    We investigate the formation and stability of icosahedral quasicrystalline structures using a dynamic phase field crystal model. Nonlinear interactions between density waves at two length scales stabilize three-dimensional quasicrystals. We determine the phase diagram and parameter values required for the quasicrystal to be the global minimum free energy state. We demonstrate that traits that promote the formation of two-dimensional quasicrystals are extant in three dimensions, and highlight the characteristics required for three-dimensional soft matter quasicrystal formation. PMID:27563973

  18. Changes in the thermal properties of PADC film-based nuclear track detectors produced by high doses of γ-radiation

    NASA Astrophysics Data System (ADS)

    Saad, A. F.; Saad, Noura; Abdalla, Y. K.

    2014-04-01

    Irradiation effects on the thermal properties of poly allyl diglycol carbonate (PADC) polymer-based nuclear track detectors (in the form of CR-39) have been investigated. PADC films were exposed to γ-rays at high doses ranging from 5.0 × 105 to 1.0 × 106 Gy. The induced modifications were analyzed by means of thermogravimetric analysis, which indicated that the PADC film decomposed in three main stages. The activation energy for thermal decomposition was determined using a type of Arrhenius equation based on the TGA experimental results. This study presents quantitative results showing that the exposed PADC films do not undergo continual further degradation from high-energy γ-photons with increase in dose. The experimental results also provide insight into the specific property changes induced by γ-rays, which may be of use for industrial applications.

  19. Dose reconstruction technique using non-rigid registration to evaluate spatial correspondence between high-dose region and late radiation toxicity: a case of tracheobronchial stenosis after external beam radiotherapy combined with endotracheal brachytherapy for tracheal cancer

    PubMed Central

    Murakami, Naoya; Inaba, Koji; Wakita, Akihisa; Nakamura, Satoshi; Okamoto, Hiroyuki; Sato, Jun; Umezawa, Rei; Takahashi, Kana; Igaki, Hiroshi; Ito, Yoshinori; Shigematsu, Naoyuki; Itami, Jun

    2016-01-01

    Purpose Small organ subvolume irradiated by a high-dose has been emphasized to be associated with late complication after radiotherapy. Here, we demonstrate a potential use of surface-based, non-rigid registration to investigate how high-dose volume topographically correlates with the location of late radiation morbidity in a case of tracheobronchial radiation stenosis. Material and methods An algorithm of point set registration was implemented to handle non-rigid registration between contour points on the organ surfaces. The framework estimated the global correspondence between the dose distribution and the varying anatomical structure. We applied it to an 80-year-old man who developed tracheobronchial stenosis 2 years after high-dose-rate endobronchial brachytherapy (HDR-EBT) (24 Gy in 6 Gy fractions) and external beam radiotherapy (EBRT) (40 Gy in 2 Gy fractions) for early-stage tracheal cancer. Results and conclusions Based on the transformation function computed by the non-rigid registration, irradiated dose distribution was reconstructed on the surface of post-treatment tracheobronchial stenosis. For expressing the equivalent dose in a fractional dose of 2 Gy in HDR-EBT, α/β of linear quadratic model was assumed as 3 Gy for the tracheal bronchus. The tracheobronchial surface irradiated by more than 100 Gyαβ3 tended to develop severe stenosis, which attributed to a more than 50% decrease in the luminal area. The proposed dose reconstruction technique can be a powerful tool to predict late radiation toxicity with spatial consideration. PMID:27257421

  20. Three-Dimensional Printing Surgical Applications

    PubMed Central

    Griffin, Michelle F.; Butler, Peter E.

    2015-01-01

    Introduction: Three-dimensional printing, a technology used for decades in the industrial field, gains a lot of attention in the medical field for its potential benefits. With advancement of desktop printers, this technology is accessible and a lot of research is going on in the medical field. Objective: To evaluate its application in surgical field, which may include but not limited to surgical planning, surgical education, implants, and prosthesis, which are the focus of this review. Methods: Research was conducted by searching PubMed, Web of science, and other reliable sources. We included original articles and excluded articles based on animals, those more than 10 years old, and those not in English. These articles were evaluated, and relevant studies were included in this review. Discussion: Three-dimensional printing shows a potential benefit in surgical application. Printed implants were used in patient in a few cases and show successful results; however, longer follow-up and more trials are needed. Surgical and medical education is believed to be more efficient with this technology than the current practice. Printed surgical instrument and surgical planning are also believed to improve with three-dimensional printing. Conclusion: Three-dimensional printing can be a very powerful tool in the near future, which can aid the medical field that is facing a lot of challenges and obstacles. However, despite the reported results, further research on larger samples and analytical measurements should be conducted to ensure this technology's impact on the practice. PMID:26301002

  1. Three Dimensional Display Of Meteorological Scientific Data

    NASA Astrophysics Data System (ADS)

    Grotch, Stanley L.

    1988-01-01

    Even a cursory reading of any daily newspaper shows that we are in the midst of a dramatic revolution in computer graphics. Virtually every day some new piece of hardware or software is announced, adding to the tools available to the working scientist. Three dimensional graphics form a significant part of this revolution having become virtually commonplace in advertising and on television.

  2. Three-Dimensional Messages for Interstellar Communication

    NASA Astrophysics Data System (ADS)

    Vakoch, Douglas A.

    One of the challenges facing independently evolved civilizations separated by interstellar distances is to communicate information unique to one civilization. One commonly proposed solution is to begin with two-dimensional pictorial representations of mathematical concepts and physical objects, in the hope that this will provide a foundation for overcoming linguistic barriers. However, significant aspects of such representations are highly conventional, and may not be readily intelligible to a civilization with different conventions. The process of teaching conventions of representation may be facilitated by the use of three-dimensional representations redundantly encoded in multiple formats (e.g., as both vectors and as rasters). After having illustrated specific conventions for representing mathematical objects in a three-dimensional space, this method can be used to describe a physical environment shared by transmitter and receiver: a three-dimensional space defined by the transmitter--receiver axis, and containing stars within that space. This method can be extended to show three-dimensional representations varying over time. Having clarified conventions for representing objects potentially familiar to both sender and receiver, novel objects can subsequently be depicted. This is illustrated through sequences showing interactions between human beings, which provide information about human behavior and personality. Extensions of this method may allow the communication of such culture-specific features as aesthetic judgments and religious beliefs. Limitations of this approach will be noted, with specific reference to ETI who are not primarily visual.

  3. Three-Dimensional Visualization of Particle Tracks.

    ERIC Educational Resources Information Center

    Julian, Glenn M.

    1993-01-01

    Suggests ways to bring home to the introductory physics student some of the excitement of recent discoveries in particle physics. Describes particle detectors and encourages the use of the Standard Model along with real images of particle tracks to determine three-dimensional views of tracks. (MVL)

  4. Three-dimensional RF structure calculations

    NASA Astrophysics Data System (ADS)

    Cooper, R. K.; Browman, M. J.; Weiland, T.

    1989-04-01

    The calculation of three-dimensional rf structures is rapidly approaching adolescence, after having been in its infancy for the last four years. This paper will show the kinds of calculations that are currently being performed in the frequency domain and is a companion paper to one in which time-domain calculations are described.

  5. Three-dimensional rf structure calculations

    SciTech Connect

    Cooper, R.K.; Browman, M.J.; Weiland, T.

    1988-01-01

    The calculation of three-dimensional rf structures is rapidly approaching adolescence, after having been in its infancy for the last four years. This paper will show the kinds of calculations that are currently being performed in the frequency domain and is a companion paper to one in which time-domain calculations are described. 13 refs., 14 figs.

  6. Three-dimensional colorimetric assay assemblies

    DOEpatents

    Charych, Deborah; Reichert, Anke

    2001-01-01

    A direct assay is described using novel three-dimensional polymeric assemblies which change from a blue to red color when exposed to an analyte, in one case a flue virus. The assemblies are typically in the form of liposomes which can be maintained in a suspension, and show great intensity in their color changes. Their method of production is also described.

  7. Three-dimensional simulations of Nova capsule implosion experiments

    SciTech Connect

    Marinak, M.M.; Tipton, R.E.; Landen, O.L.

    1995-11-01

    Capsule implosion experiments carried out on the Nova laser are simulated with the three-dimensional HYDRA radiation hydrodynamics code. Simulations of ordered near single mode perturbations indicate that structures which evolve into round spikes can penetrate farthest into the hot spot. Bubble-shaped perturbations can burn through the capsule shell fastest, however, causing even more damage. Simulations of a capsule with multimode perturbations shows spike amplitudes evolving in good agreement with a saturation model during the deceleration phase. The presence of sizable low mode asymmetry, caused either by drive asymmetry or perturbations in the capsule shell, can dramatically affect the manner in which spikes approach the center of the hot spot. Three-dimensional coupling between the low mode shell perturbations intrinsic to Nova capsules and the drive asymmetry brings the simulated yields into closer agreement with the experimental values.

  8. Assessment of three-dimensional set-up errors using megavoltage computed tomography (MVCT) during image-guided intensity-modulated radiation therapy (IMRT) for craniospinal irradiation (CSI) on helical tomotherapy (HT).

    PubMed

    Gupta, Tejpal; Upasani, Maheshkumar; Master, Zubin; Patil, Anita; Phurailatpam, Reena; Nojin, Siji; Kannan, Sadhana; Godasastri, Jayant; Jalali, Rakesh

    2015-02-01

    The purpose of this study was to assess three-dimensional (3D) set-up errors using megavoltage computed tomography (MVCT) during image-guided intensity-modulated radiation therapy (IMRT) for supine craniospinal irradiation (CSI) on helical tomotherapy (HT). Patients were immobilized in a customized 4-clamp thermoplastic head mask with or without whole-body vacuum cradle. Set-up was based primarily on a set of cranial fiducial markers. MVCT scans were acquired and co-registered with planning scan separately at three different levels (brain, upper, and lower spine) at every fraction. Only translational displacements were analysed, wherein positive sign denotes deviation in anterior, left, and superior direction; while negative sign denotes deviation in posterior, right, and inferior direction. Mean displacements, systematic, and random errors of the study population were calculated at all three levels separately. Local residual uncertainty of the upper and lower spine was also derived assuming perfect co-registration of the skull. Set-up margins for clinical target volume (CTV) to planning target volume (PTV) were derived at these three levels separately using published margin recipes. Data from 1868 co-registrations in 674 fractions on 33 patients was included. The mean displacements in the lateral, longitudinal, and vertical directions were -1.21, -1.36, and 1.38 mm; -1.25, -0.34, and 0.65 mm; and -1.47, -2.78, and 0.22 mm for the brain; upper spine; and lumbar spine respectively. The corresponding 3D vector of displacement was 2.28; 1.45; and 3.15 mm respectively. There was a distinct systematic trend towards increasing inaccuracy from the brain towards the lower spine. Using Stroom's formula, the minimum recommended CTV to PTV margins in absence of daily image-guidance were 6.5; 7.0; and 9.5 mm for the brain; upper spine; and lower spine respectively. This increased to 7.5; 8.5; and 11.5 mm using van Herk's formula. Subset and sensitivity analyses

  9. Three-dimensional theory of stimulated Raman scattering

    NASA Astrophysics Data System (ADS)

    Sørensen, Martin W.; Sørensen, Anders S.

    2009-09-01

    We present a three-dimensional theory of stimulated Raman scattering (SRS) or super-radiance. In particular we address how the spatial and temporal properties of the generated SRS beam or Stokes beam of radiation depends on the spatial properties of the gain medium. Maxwell equations for the Stokes field operators and of the atomic operators are solved analytically and a correlation function for the Stokes field is derived. In the analysis we identify a super-radiating part of the Stokes radiation that exhibit beam characteristics. We show how the intensity in this beam builds up in time and at some point largely dominates the total Stokes radiation of the gain medium. We show how the SRS depends on the Fresnel number and the optical depth and that in fact these two factors are the only factors describing the coherent radiation.

  10. Three-dimensional whispering gallery modes in InGaAs nanoneedle lasers on silicon

    SciTech Connect

    Tran, T.-T. D.; Chen, R.; Ng, K. W.; Ko, W. S.; Lu, F.; Chang-Hasnain, C. J.

    2014-09-15

    As-grown InGaAs nanoneedle lasers, synthesized at complementary metal–oxide–semiconductor compatible temperatures on polycrystalline and crystalline silicon substrates, were studied in photoluminescence experiments. Radiation patterns of three-dimensional whispering gallery modes were observed upon optically pumping the needles above the lasing threshold. Using the radiation patterns as well as finite-difference-time-domain simulations and polarization measurements, all modal numbers of the three-dimensional whispering gallery modes could be identified.

  11. Comparison of Patient Dose in Two-Dimensional Carotid Arteriography and Three-Dimensional Rotational Angiography

    SciTech Connect

    Tsapaki, Virginia Vano, Eliseo; Mavrikou, Irini; Neofotistou, Vassiliki; Gallego, Juan Jose; Fernandez, Jose Miguel; Santos, Ernesto; Mendez, Jose

    2008-05-15

    Background and Purpose. It is known that interventional neuroradiology (IN) involves high radiation dose to both patients and staff even if performed by trained operators using modern fluoroscopic X-ray equipment and dose-reducing technology. Therefore, every new technology or imaging tool introduced, such as three-dimensional rotational angiography (3D RA), should be evaluated in terms of radiation dose. 3D RA requires a series with a large number of images in comparison with 2D angiography and it is sometimes considered a high-dose IN procedure. The literature is scarce on the 3D RA radiation dose and in particular there are no data on carotid arteriography (CA). The aim of this study was to investigate patient dose differences between 2D and 3D CA. Methods. The study included 35 patients undergoing 2D CA in hospital 1 and 25 patients undergoing 3D CA in hospital 2. Patient technical data collection included information on the kerma area product (KAP), fluoroscopy time (T), total number of series (S), and total number of acquired images (F). Results. Median KAP was 112 Gy cm{sup 2} and 41 Gy cm{sup 2} for hospitals 1 and 2, respectively, median T was 8.2 min and 5.1 min, median S was 13 and 4, and median F was 247 and 242. Entrance surface air-kerma rate, as measured in 'medium' fluoroscopy mode measured in 2D acquisition using a 20 cm phantom of polymethylmethacrylate, was 17.3 mGy/min for hospital 1 and 9.2 mGy/min for hospital 2. Conclusion. 3D CA allows a substantial reduction in patient radiation dose compared with 2D CA, while providing the necessary diagnostic information.

  12. Comparative Analysis of Whole-Genome Gene Expression Changes in Cultured Human Embryonic Stem Cells in Response to Low, Clinical Diagnostic Relevant, and High Doses of Ionizing Radiation Exposure.

    PubMed

    Sokolov, Mykyta; Nguyen, Van; Neumann, Ronald

    2015-01-01

    The biological effects of low-dose ionizing radiation (LDIR) exposure in humans are not comprehensively understood, generating a high degree of controversy in published literature. The earliest stages of human development are known to be among the most sensitive to stress exposures, especially genotoxic stresses. However, the risks stemming from exposure to LDIR, particularly within the clinical diagnostic relevant dose range, have not been directly evaluated in human embryonic stem cells (hESCs). Here, we describe the dynamics of the whole genome transcriptional responses of different hESC lines to both LDIR and, as a reference, high-dose IR (HDIR). We found that even doses as low as 0.05 Gy could trigger statistically significant transient changes in a rather limited subset of genes in all hESCs lines examined. Gene expression signatures of hESCs exposed to IR appear to be highly dose-, time-, and cell line-dependent. We identified 50 genes constituting consensus gene expression signature as an early response to HDIR across all lines of hESC examined. We observed substantial differences in biological pathways affected by either LDIR or HDIR in hESCs, suggesting that the molecular mechanisms underpinning the responses of hESC may fundamentally differ depending on radiation doses. PMID:26133243

  13. Artifacts in three-dimensional transesophageal echocardiography.

    PubMed

    Faletra, Francesco Fulvio; Ramamurthi, Alamelu; Dequarti, Maria Cristina; Leo, Laura Anna; Moccetti, Tiziano; Pandian, Natesa

    2014-05-01

    Three-dimensional (3D) transesophageal echocardiography (TEE) is subject to the same types of artifacts encountered on two-dimensional TEE. However, when displayed in a 3D format, some of the artifacts appear more "realistic," whereas others are unique to image acquisition and postprocessing. Three-dimensional TEE is increasingly used in the setting of percutaneous catheter-based interventions and ablation procedures, and 3D artifacts caused by the metallic components of catheters and devices are particularly frequent. Knowledge of these artifacts is of paramount relevance to avoid misinterpretation of 3D images. Although artifacts and pitfalls on two-dimensional echocardiography are well described and classified, a systematic description of artifacts in 3D transesophageal echocardiographic images and how they affect 3D imaging is still absent. The aim of this review is to describe the most relevant artifacts on 3D TEE, with particular emphasis on those occurring during percutaneous interventions for structural heart disease and ablation procedures.

  14. Real time three dimensional sensing system

    DOEpatents

    Gordon, S.J.

    1996-12-31

    The invention is a three dimensional sensing system which utilizes two flexibly located cameras for receiving and recording visual information with respect to a sensed object illuminated by a series of light planes. Each pixel of each image is converted to a digital word and the words are grouped into stripes, each stripe comprising contiguous pixels. One pixel of each stripe in one image is selected and an epi-polar line of that point is drawn in the other image. The three dimensional coordinate of each selected point is determined by determining the point on said epi-polar line which also lies on a stripe in the second image and which is closest to a known light plane. 7 figs.

  15. Three-dimensional effects on airfoils

    NASA Technical Reports Server (NTRS)

    Chevallier, J. P.

    1983-01-01

    The effects of boundary layer flows along the walls of wind tunnels were studied to validate the transfer of two dimensional calculations to three dimensional transonic flowfield calculations. Results from trials in various wind tunnels were examind to determine the effects of the wall boundary flow on the control surfaces of an airfoil. Models sliding along a groove in the wall of a channel at sub- and transonic speeds were examined, with the finding that with either nonuniformities in the groove, or even if the channel walls are uniform, the lateral boundary layer can cause variations in the central flow region or alter the onset of shock at the transition point. Models for the effects in both turbulence and in the absence of turbulence are formulated, and it is noted that the characteristics of individual wind tunnels must be studied to quantify any existing three dimensional effects.

  16. Three-Dimensional Reconstruction of Helical Polymers

    PubMed Central

    Egelman, Edward H.

    2015-01-01

    The field of three-dimensional electron microscopy began more than 45 years ago with a reconstruction of a helical phage tail, and helical polymers continue to be important objects for three-dimensional reconstruction due to the centrality of helical protein and nucleoprotein polymers in all aspects of biology. We are now witnessing a fundamental revolution in this area, made possible by direct electron detectors, which has led to near-atomic resolution for a number of important helical structures. Most importantly, the possibility of achieving such resolution routinely for a vast number of helical samples is within our reach. One of the main problems in helical reconstruction, ambiguities in assigning the helical symmetry, is overcome when one reaches a resolution where secondary structure is clearly visible. However, obstacles still exist due to the intrinsic variability within many helical filaments. PMID:25912526

  17. Three dimensional fabrication at small size scales

    PubMed Central

    Leong, Timothy G.; Zarafshar, Aasiyeh M.; Gracias, David H.

    2010-01-01

    Despite the fact that we live in a three-dimensional (3D) world and macroscale engineering is 3D, conventional sub-mm scale engineering is inherently two-dimensional (2D). New fabrication and patterning strategies are needed to enable truly three-dimensionally-engineered structures at small size scales. Here, we review strategies that have been developed over the last two decades that seek to enable such millimeter to nanoscale 3D fabrication and patterning. A focus of this review is the strategy of self-assembly, specifically in a biologically inspired, more deterministic form known as self-folding. Self-folding methods can leverage the strengths of lithography to enable the construction of precisely patterned 3D structures and “smart” components. This self-assembling approach is compared with other 3D fabrication paradigms, and its advantages and disadvantages are discussed. PMID:20349446

  18. Three dimensional contact/impact methodology

    SciTech Connect

    Kulak, R.F.

    1987-01-01

    The simulation of three-dimensional interface mechanics between reactor components and structures during static contact or dynamic impact is necessary to realistically evaluate their structural integrity to off-normal loads. In our studies of postulated core energy release events, we have found that significant structure-structure interactions occur in some reactor vessel head closure designs and that fluid-structure interactions occur within the reactor vessel. Other examples in which three-dimensional interface mechanics play an important role are: (1) impact response of shipping casks containing spent fuel, (2) whipping pipe impact on reinforced concrete panels or pipe-to-pipe impact after a pipe break, (3) aircraft crash on secondary containment structures, (4) missiles generated by turbine failures or tornados, and (5) drops of heavy components due to lifting accidents. The above is a partial list of reactor safety problems that require adequate treatment of interface mechanics and are discussed in this paper.

  19. Three-dimensional bio-printing.

    PubMed

    Gu, Qi; Hao, Jie; Lu, YangJie; Wang, Liu; Wallace, Gordon G; Zhou, Qi

    2015-05-01

    Three-dimensional (3D) printing technology has been widely used in various manufacturing operations including automotive, defence and space industries. 3D printing has the advantages of personalization, flexibility and high resolution, and is therefore becoming increasingly visible in the high-tech fields. Three-dimensional bio-printing technology also holds promise for future use in medical applications. At present 3D bio-printing is mainly used for simulating and reconstructing some hard tissues or for preparing drug-delivery systems in the medical area. The fabrication of 3D structures with living cells and bioactive moieties spatially distributed throughout will be realisable. Fabrication of complex tissues and organs is still at the exploratory stage. This review summarize the development of 3D bio-printing and its potential in medical applications, as well as discussing the current challenges faced by 3D bio-printing. PMID:25921944

  20. Three-dimensional reconstruction of helical polymers.

    PubMed

    Egelman, Edward H

    2015-09-01

    The field of three-dimensional electron microscopy began more than 45years ago with a reconstruction of a helical phage tail, and helical polymers continue to be important objects for three-dimensional reconstruction due to the centrality of helical protein and nucleoprotein polymers in all aspects of biology. We are now witnessing a fundamental revolution in this area, made possible by direct electron detectors, which has led to near-atomic resolution for a number of important helical structures. Most importantly, the possibility of achieving such resolution routinely for a vast number of helical samples is within our reach. One of the main problems in helical reconstruction, ambiguities in assigning the helical symmetry, is overcome when one reaches a resolution where secondary structure is clearly visible. However, obstacles still exist due to the intrinsic variability within many helical filaments.

  1. Three-dimensional bio-printing.

    PubMed

    Gu, Qi; Hao, Jie; Lu, YangJie; Wang, Liu; Wallace, Gordon G; Zhou, Qi

    2015-05-01

    Three-dimensional (3D) printing technology has been widely used in various manufacturing operations including automotive, defence and space industries. 3D printing has the advantages of personalization, flexibility and high resolution, and is therefore becoming increasingly visible in the high-tech fields. Three-dimensional bio-printing technology also holds promise for future use in medical applications. At present 3D bio-printing is mainly used for simulating and reconstructing some hard tissues or for preparing drug-delivery systems in the medical area. The fabrication of 3D structures with living cells and bioactive moieties spatially distributed throughout will be realisable. Fabrication of complex tissues and organs is still at the exploratory stage. This review summarize the development of 3D bio-printing and its potential in medical applications, as well as discussing the current challenges faced by 3D bio-printing.

  2. Three-dimensional imaging modalities in endodontics

    PubMed Central

    Mao, Teresa

    2014-01-01

    Recent research in endodontics has highlighted the need for three-dimensional imaging in the clinical arena as well as in research. Three-dimensional imaging using computed tomography (CT) has been used in endodontics over the past decade. Three types of CT scans have been studied in endodontics, namely cone-beam CT, spiral CT, and peripheral quantitative CT. Contemporary endodontics places an emphasis on the use of cone-beam CT for an accurate diagnosis of parameters that cannot be visualized on a two-dimensional image. This review discusses the role of CT in endodontics, pertaining to its importance in the diagnosis of root canal anatomy, detection of peri-radicular lesions, diagnosis of trauma and resorption, presurgical assessment, and evaluation of the treatment outcome. PMID:25279337

  3. Real time three dimensional sensing system

    DOEpatents

    Gordon, Steven J.

    1996-01-01

    The invention is a three dimensional sensing system which utilizes two flexibly located cameras for receiving and recording visual information with respect to a sensed object illuminated by a series of light planes. Each pixel of each image is converted to a digital word and the words are grouped into stripes, each stripe comprising contiguous pixels. One pixel of each stripe in one image is selected and an epi-polar line of that point is drawn in the other image. The three dimensional coordinate of each selected point is determined by determining the point on said epi-polar line which also lies on a stripe in the second image and which is closest to a known light plane.

  4. Three-dimensional Allan fault plane analysis

    SciTech Connect

    Hoffman, K.S.; Taylor, D.R.; Schnell, R.T.

    1994-12-31

    Allan fault-plane analysis is a useful tool for determining hydrocarbon migration paths and the location of possible traps. While initially developed for Gulf coast deltaic and interdeltaic environments, fault-plane analysis has been successfully applied in many other geologic settings. Where the geology involves several intersecting faults and greater complexity, many two-dimensional displays are required in the investigation and it becomes increasingly difficult to accurately visualize both fault relationships and migration routes. Three-dimensional geospatial fault and structure modeling using computer techniques, however, facilitates both visualization and understanding and extends fault-plane analysis into much more complex situations. When a model is viewed in three dimensions, the strata on both sides of a fault can be seen simultaneously while the true structural character of one or more fault surfaces is preserved. Three-dimensional analysis improves the speed and accuracy of the fault plane methodology.

  5. Simulation of complex three-dimensional flows

    NASA Technical Reports Server (NTRS)

    Diewert, G. S.; Rothmund, H. J.; Nakahashi, K.

    1985-01-01

    The concept of splitting is used extensively to simulate complex three dimensional flows on modern computer architectures. Used in all aspects, from initial grid generation to the determination of the final converged solution, splitting is used to enhance code vectorization, to permit solution driven grid adaption and grid enrichment, to permit the use of concurrent processing, and to enhance data flow through hierarchal memory systems. Three examples are used to illustrate these concepts to complex three dimensional flow fields: (1) interactive flow over a bump; (2) supersonic flow past a blunt based conical afterbody at incidence to a free stream and containing a centered propulsive jet; and (3) supersonic flow past a sharp leading edge delta wing at incidence to the free stream.

  6. Three-dimensional Lorentz-violating action

    NASA Astrophysics Data System (ADS)

    Nascimento, J. R.; Petrov, A. Yu.; Wotzasek, C.; Zarro, C. A. D.

    2014-03-01

    We demonstrate the generation of the three-dimensional Chern-Simons-like Lorentz-breaking "mixed" quadratic action via an appropriate Lorentz-breaking coupling of vector and scalar fields to the spinor field and study some features of the scalar QED with such a term. We show that the same term emerges through a nonperturbative method, namely the Julia-Toulouse approach of condensation of charges and defects.

  7. Three-dimensional ballistocardiography in weightlessness

    NASA Technical Reports Server (NTRS)

    Scano, A.

    1981-01-01

    An experiment is described the aim of which is to record a three dimensional ballistocardiogram under the condition of weightlessness and to compare it with tracings recorded on the same subject on the ground as a means of clarifying the meaning of ballistocardiogram waves in different physiological and perphaps pathological conditions. Another purpose is to investigate cardiovascular and possibly fluid adaptations to weightlessness from data collected almost simultaneously on the same subjects during the other cardiovascular during the other cardiovascular and metabolic experiments.

  8. Stress tensor correlators in three dimensional gravity

    NASA Astrophysics Data System (ADS)

    Bagchi, Arjun; Grumiller, Daniel; Merbis, Wout

    2016-03-01

    We calculate holographically arbitrary n -point correlators of the boundary stress tensor in three-dimensional Einstein gravity with negative or vanishing cosmological constant. We provide explicit expressions up to 5-point (connected) correlators and show consistency with the Galilean conformal field theory Ward identities and recursion relations of correlators, which we derive. This provides a novel check of flat space holography in three dimensions.

  9. Three-Dimensional Dispaly Of Document Set

    DOEpatents

    Lantrip, David B.; Pennock, Kelly A.; Pottier, Marc C.; Schur, Anne; Thomas, James J.; Wise, James A.

    2003-06-24

    A method for spatializing text content for enhanced visual browsing and analysis. The invention is applied to large text document corpora such as digital libraries, regulations and procedures, archived reports, and the like. The text content from these sources may be transformed to a spatial representation that preserves informational characteristics from the documents. The three-dimensional representation may then be visually browsed and analyzed in ways that avoid language processing and that reduce the analysts' effort.

  10. Three-dimensional display of document set

    DOEpatents

    Lantrip, David B [Oxnard, CA; Pennock, Kelly A [Richland, WA; Pottier, Marc C [Richland, WA; Schur, Anne [Richland, WA; Thomas, James J [Richland, WA; Wise, James A [Richland, WA

    2001-10-02

    A method for spatializing text content for enhanced visual browsing and analysis. The invention is applied to large text document corpora such as digital libraries, regulations and procedures, archived reports, and the like. The text content from these sources may be transformed to a spatial representation that preserves informational characteristics from the documents. The three-dimensional representation may then be visually browsed and analyzed in ways that avoid language processing and that reduce the analysts' effort.

  11. Three-dimensional display of document set

    DOEpatents

    Lantrip, David B.; Pennock, Kelly A.; Pottier, Marc C.; Schur, Anne; Thomas, James J.; Wise, James A.

    2006-09-26

    A method for spatializing text content for enhanced visual browsing and analysis. The invention is applied to large text document corpora such as digital libraries, regulations and procedures, archived reports, and the like. The text content from these sources may e transformed to a spatial representation that preserves informational characteristics from the documents. The three-dimensional representation may then be visually browsed and analyzed in ways that avoid language processing and that reduce the analysts' effort.

  12. Three-dimensional display of document set

    DOEpatents

    Lantrip, David B.; Pennock, Kelly A.; Pottier, Marc C.; Schur, Anne; Thomas, James J.; Wise, James A.; York, Jeremy

    2009-06-30

    A method for spatializing text content for enhanced visual browsing and analysis. The invention is applied to large text document corpora such as digital libraries, regulations and procedures, archived reports, and the like. The text content from these sources may be transformed to a spatial representation that preserves informational characteristics from the documents. The three-dimensional representation may then be visually browsed and analyzed in ways that avoid language processing and that reduce the analysts' effort.

  13. Three-dimensional printing of scintillating materials.

    PubMed

    Mishnayot, Y; Layani, M; Cooperstein, I; Magdassi, S; Ron, G

    2014-08-01

    We demonstrate, for the first time, the applicability of three-dimensional printing techniques to the manufacture of scintillation detectors. We report on the development of a formulation, usable in stereolithographic printing, that exhibits scintillation efficiency on the order of 30% of that of commercial polystyrene based scintillators. We discuss the applicability of these techniques and propose future enhancements that will allow tailoring the printed scintillation detectors to various applications.

  14. Three-Dimensional Printing in Orthopedic Surgery.

    PubMed

    Eltorai, Adam E M; Nguyen, Eric; Daniels, Alan H

    2015-11-01

    Three-dimensional (3D) printing is emerging as a clinically promising technology for rapid prototyping of surgically implantable products. With this commercially available technology, computed tomography or magnetic resonance images can be used to create graspable objects from 3D reconstructed images. Models can enhance patients' understanding of their pathology and surgeon preoperative planning. Customized implants and casts can be made to match an individual's anatomy. This review outlines 3D printing, its current applications in orthopedics, and promising future directions.

  15. Method and apparatus for three dimensional braiding

    NASA Technical Reports Server (NTRS)

    Farley, Gary L. (Inventor)

    1997-01-01

    A machine for three-dimensional braiding of fibers is provided in which carrier members travel on a curved, segmented and movable braiding surface. The carrier members are capable of independent, self-propelled motion along the braiding surface. Carrier member position on the braiding surface is controlled and monitored by computer. Also disclosed is a yarn take-up device capable of maintaining tension in the braiding fiber.

  16. Method and apparatus for three dimensional braiding

    NASA Technical Reports Server (NTRS)

    Farley, Gary L. (Inventor)

    1995-01-01

    A machine for three-dimensional braiding of fibers is provided in which carrier members travel on a curved, segmented and movable braiding surface. The carrier members are capable of independent, self-propelled motion along the braiding surface. Carrier member position on the braiding surface is controlled and monitored by computer. Also disclosed is a yarn take-up device capable of maintaining tension in the braiding fiber.

  17. Mineralized three-dimensional bone constructs

    NASA Technical Reports Server (NTRS)

    Clarke, Mark S. F. (Inventor); Sundaresan, Alamelu (Inventor); Pellis, Neal R. (Inventor)

    2011-01-01

    The present disclosure provides ex vivo-derived mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts and osteoclast precursors under randomized gravity vector conditions. Preferably, the randomized gravity vector conditions are obtained using a low shear stress rotating bioreactor, such as a High Aspect Ratio Vessel (HARV) culture system. The bone constructs of the disclosure have utility in physiological studies of bone formation and bone function, in drug discovery, and in orthopedics.

  18. Mineralized Three-Dimensional Bone Constructs

    NASA Technical Reports Server (NTRS)

    Clarke, Mark S. F. (Inventor); Sundaresan, Alamelu (Inventor); Pellis, Neal R. (Inventor)

    2013-01-01

    The present disclosure provides ex vivo-derived mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts and osteoclast precursors under randomized gravity vector conditions. Preferably, the randomized gravity vector conditions are obtained using a low shear stress rotating bioreactor, such as a High Aspect Ratio Vessel (HARV) culture system. The bone constructs of the disclosure have utility in physiological studies of bone formation and bone function, in drug discovery, and in orthopedics.

  19. Three-dimensional motor schema based navigation

    NASA Technical Reports Server (NTRS)

    Arkin, Ronald C.

    1989-01-01

    Reactive schema-based navigation is possible in space domains by extending the methods developed for ground-based navigation found within the Autonomous Robot Architecture (AuRA). Reformulation of two dimensional motor schemas for three dimensional applications is a straightforward process. The manifold advantages of schema-based control persist, including modular development, amenability to distributed processing, and responsiveness to environmental sensing. Simulation results show the feasibility of this methodology for space docking operations in a cluttered work area.

  20. Three-dimensional adjustment of trilateration data

    NASA Technical Reports Server (NTRS)

    Sung, L.-Y.; Jackson, D. D.

    1985-01-01

    The three-dimensional locations of the monuments in the USGS Hollister trilateration network were adjusted to fit line length observations observed in 1977, using a Bayesian approach, and incorporating prior elevation estimates as data in the adjustment procedure. No significant discrepancies in the measured line lengths were found, but significant elevation adjustments (up to 1.85 m) were needed to fit the length data.

  1. Three-dimensional photogrammetry for laboratory applications

    NASA Astrophysics Data System (ADS)

    Alem, Nabih M.

    1994-12-01

    The direct linear transformation (DLT) is a method that simplifies measurements of the three-dimensional coordinates of a point target in the laboratory using photographic two-dimensional imagery. This report describes a procedure to implement the DLT equations and gives the Fortran code of computer programs for the DLT calibration of multicamera system and 3-D reconstruction of a single point from several images.

  2. Dosimetry analyses comparing high-dose-rate brachytherapy, administered as monotherapy for localized prostate cancer, with stereotactic body radiation therapy simulated using CyberKnife

    PubMed Central

    Fukuda, Shoichi; Seo, Yuji; Shiomi, Hiroya; Yamada, Yuji; Ogata, Toshiyuki; Morimoto, Masahiro; Konishi, Koji; Yoshioka, Yasuo; Ogawa, Kazuhiko

    2014-01-01

    The purpose of this study was to perform dosimetry analyses comparing high-dose-rate brachytherapy (HDR-BT) with simulated stereotactic body radiotherapy (SBRT). We selected six consecutive patients treated with HDR-BT monotherapy in 2010, and a CyberKnife SBRT plan was simulated for each patient using computed tomography images and the contouring set used in the HDR-BT plan for the actual treatment, but adding appropriate planning target volume (PTV) margins for SBRT. Then, dosimetric profiles for PTVs of the rectum, bladder and urethra were compared between the two modalities. The SBRT plan was more homogenous and provided lower dose concentration but better coverage for the PTV. The maximum doses in the rectum were higher in the HDR-BT plans. However, the HDR-BT plan provided a sharper dose fall-off around the PTV, resulting in a significant and considerable difference in volume sparing of the rectum with the appropriate PTV margins added for SBRT. While the rectum D5cm3 for HDR-BT and SBRT was 30.7 and 38.3 Gy (P < 0.01) and V40 was 16.3 and 20.8 cm3 (P < 0.01), respectively, SBRT was significantly superior in almost all dosimetric profiles for the bladder and urethra. These results suggest that SBRT as an alternative to HDR-BT in hypofractionated radiotherapy for prostate cancer might have an advantage for bladder and urethra dose sparing, but for the rectum only when proper PTV margins for SBRT are adopted. PMID:24957754

  3. Effect of High-Dose-Rate {sup 192}Ir Source Activity on Late Rectal Bleeding After Intracavitary Radiation Therapy for Uterine Cervix Cancer

    SciTech Connect

    Suzuki, Osamu Yoshioka, Yasuo; Isohashi, Fumiaki; Morimoto, Masahiro; Kotsuma, Tadayuki; Kawaguchi, Yoshifumi; Konishi, Koji; Nakamura, Satoaki; Shiomi, Hiroya; Inoue, Takehiro

    2008-08-01

    Purpose: This retrospective study analyzed the effect of the activity of high-dose-rate (HDR) {sup 192}Ir source on late rectal bleeding after HDR intracavitary radiotherapy (ICRT) in patients with uterine cervix cancer. Methods and Materials: One hundred thirty-two patients who underwent HDR-ICRT and external beam radiotherapy (EBRT) were analyzed. The rectal point dose in ICRT was calculated by inserting a lead wire into the rectal lumen and summed with the whole-pelvic EBRT dose. The rectal biologic effective dose (BED) was calculated. The relationship between averaged source activity or the BED and late rectal bleeding were analyzed. Results: Three-year actuarial rectal bleeding probabilities were 46% ({>=}100 Gy{sub 3}) and 18% ({<=} 100 Gy{sub 3}), respectively (p < 0.005). When patients were divided into four groups according to rectal BED ({>=} or {<=}100 Gy{sub 3}) and source activity ({>=} or {<=}2.4 cGy.m{sup 2}.h{sup -1}), the group with both a high BED and high activity showed significantly greater probability (58% at 3 years; p < 0.005). It was noted that the probability of the group with BED of 100 Gy{sub 3} or greater was high, but that was not the case with 2.4 cGy.m{sup 2}.h{sup -1} or less. Conclusion: This is the first clinical report concerning the source activity effect of HDR {sup 192}Ir on late rectal bleeding in patients undergoing HDR-ICRT. This suggests that when source activity is higher than 2.4 cGy.m{sup 2}.h{sup -1}, ICRT should be performed with more caution not to exceed 100 Gy{sub 3} in total.

  4. Three-Dimensional Audio Client Library

    NASA Technical Reports Server (NTRS)

    Rizzi, Stephen A.

    2005-01-01

    The Three-Dimensional Audio Client Library (3DAudio library) is a group of software routines written to facilitate development of both stand-alone (audio only) and immersive virtual-reality application programs that utilize three-dimensional audio displays. The library is intended to enable the development of three-dimensional audio client application programs by use of a code base common to multiple audio server computers. The 3DAudio library calls vendor-specific audio client libraries and currently supports the AuSIM Gold-Server and Lake Huron audio servers. 3DAudio library routines contain common functions for (1) initiation and termination of a client/audio server session, (2) configuration-file input, (3) positioning functions, (4) coordinate transformations, (5) audio transport functions, (6) rendering functions, (7) debugging functions, and (8) event-list-sequencing functions. The 3DAudio software is written in the C++ programming language and currently operates under the Linux, IRIX, and Windows operating systems.

  5. Three-dimensional Chiral Plasmonic Oligomers

    NASA Astrophysics Data System (ADS)

    Hentschel, Mario

    2013-03-01

    We demonstrate chiral optical response in stacked arrangements of plasmonic nanostructures. We show that three-dimensional arrangements of plasmonic ``meta-atoms'' only exhibit a chiral optical response if similar plasmonic ``atoms'' are arranged in a handed fashion as we require resonant plasmonic coupling. Moreover, we demonstrate that such particle groupings, similarly to molecular systems, possess the capability to encode their three-dimensional arrangement in unique and well-modulated spectra, making them ideal candidates for a three-dimensional chiral plasmon ruler. Furthermore, we discuss the onset of a broadband chiral optical response in the wavelength regime between 700 nm and 3500 nm upon charge transfer between the nanoparticles. We show in experiment and simulation that this response is due to the ohmic contact between adjacent particles which causes a strong red-shift of the fundamental mode. The geometrical shape of the resulting fused particles allows for efficient excitation of higher order modes. Calculated spectra and field distributions confirm our interpretation and show a number of interacting plasmonic modes. Finally, we will discuss plasmonic diastereomers which consist of multiple chiral centers. We find that the chiral optical response of the composite molecules can be traced back to the properties of the constituting building blocks. We demonstrate that the optical response of complex chiral plasmonic systems can be decomposed and understood in terms of fundamental building blocks, offering simple and straightforward design rules for future applications such as chiral optical elements and enantiomer sensors.

  6. Reconfigurable, braced, three-dimensional DNA nanostructures

    NASA Astrophysics Data System (ADS)

    Goodman, Russell P.; Heilemann, Mike; Doose, Sören; Erben, Christoph M.; Kapanidis, Achillefs N.; Turberfield, Andrew J.

    2008-02-01

    DNA nanotechnology makes use of the exquisite self-recognition of DNA in order to build on a molecular scale. Although static structures may find applications in structural biology and computer science, many applications in nanomedicine and nanorobotics require the additional capacity for controlled three-dimensional movement. DNA architectures can span three dimensions and DNA devices are capable of movement, but active control of well-defined three-dimensional structures has not been achieved. We demonstrate the operation of reconfigurable DNA tetrahedra whose shapes change precisely and reversibly in response to specific molecular signals. Shape changes are confirmed by gel electrophoresis and by bulk and single-molecule Förster resonance energy transfer measurements. DNA tetrahedra are natural building blocks for three-dimensional construction; they may be synthesized rapidly with high yield of a single stereoisomer, and their triangulated architecture conveys structural stability. The introduction of shape-changing structural modules opens new avenues for the manipulation of matter on the nanometre scale.

  7. Multiparallel Three-Dimensional Optical Microscopy

    NASA Technical Reports Server (NTRS)

    Nguyen, Lam K.; Price, Jeffrey H.; Kellner, Albert L.; Bravo-Zanoquera, Miguel

    2010-01-01

    Multiparallel three-dimensional optical microscopy is a method of forming an approximate three-dimensional image of a microscope sample as a collection of images from different depths through the sample. The imaging apparatus includes a single microscope plus an assembly of beam splitters and mirrors that divide the output of the microscope into multiple channels. An imaging array of photodetectors in each channel is located at a different distance along the optical path from the microscope, corresponding to a focal plane at a different depth within the sample. The optical path leading to each photodetector array also includes lenses to compensate for the variation of magnification with distance so that the images ultimately formed on all the photodetector arrays are of the same magnification. The use of optical components common to multiple channels in a simple geometry makes it possible to obtain high light-transmission efficiency with an optically and mechanically simple assembly. In addition, because images can be read out simultaneously from all the photodetector arrays, the apparatus can support three-dimensional imaging at a high scanning rate.

  8. Three-dimensional printing of the retina

    PubMed Central

    Lorber, Barbara; Hsiao, Wen-Kai; Martin, Keith R.

    2016-01-01

    Purpose of review Biological three-dimensional printing has received a lot of media attention over recent years with advances made in printing cellular structures, including skin and heart tissue for transplantation. Although limitations exist in creating functioning organs with this method, the hope has been raised that creating a functional retina to cure blindness is within reach. The present review provides an update on the advances made toward this goal. Recent findings It has recently been shown that two types of retinal cells, retinal ganglion cells and glial cells, can be successfully printed using a piezoelectric inkjet printer. Importantly, the cells remained viable and did not change certain phenotypic features as a result of the printing process. In addition, recent advances in the creation of complex and viable three-dimensional cellular structures have been made. Summary Some first promising steps toward the creation of a functional retina have been taken. It now needs to be investigated whether recent findings can be extended to other cells of the retina, including those derived from human tissue, and if a complex and viable retinal structure can be created through three-dimensional printing. PMID:27045545

  9. Three-dimensional deformation of orthodontic brackets

    PubMed Central

    Melenka, Garrett W; Nobes, David S; Major, Paul W

    2013-01-01

    Braces are used by orthodontists to correct the misalignment of teeth in the mouth. Archwire rotation is a particular procedure used to correct tooth inclination. Wire rotation can result in deformation to the orthodontic brackets, and an orthodontic torque simulator has been designed to examine this wire–bracket interaction. An optical technique has been employed to measure the deformation due to size and geometric constraints of the orthodontic brackets. Images of orthodontic brackets are collected using a stereo microscope and two charge-coupled device cameras, and deformation of orthodontic brackets is measured using a three-dimensional digital image correlation technique. The three-dimensional deformation of orthodontic brackets will be evaluated. The repeatability of the three-dimensional digital image correlation measurement method was evaluated by performing 30 archwire rotation tests using the same bracket and archwire. Finally, five Damon 3MX and five In-Ovation R self-ligating brackets will be compared using this technique to demonstrate the effect of archwire rotation on bracket design. PMID:23762201

  10. Three-dimensional imaging characteristics and depth resolution in digital holographic three-dimensional imaging spectrometry

    NASA Astrophysics Data System (ADS)

    Obara, Masaki; Yoshimori, Kyu

    2015-07-01

    A four-dimensional impulse response function for the digital holographic three-dimensional imaging spectrometry has been fully derived in closed form. Due to its factorizing nature of the mathematical expression of four-dimensional impulse response function, three-dimensional spatial part of impulse response function directly corresponds to threedimensional point spread function of in-line digital holography with rectangular aperture. Based on these mathematical results, this paper focuses on the investigation of spectral resolution and three-dimensional spatial resolution in digital holographic three-dimensional imaging spectrometry and digital holography. We found that the theoretical prediction agree well with the experimental results. This work suggests a new criterion and estimate method regarding threedimensional spatial resolution of in-line digital holography.

  11. Randomized Noninferiority Trial of Reduced High-Dose Volume Versus Standard Volume Radiation Therapy for Muscle-Invasive Bladder Cancer: Results of the BC2001 Trial (CRUK/01/004)

    SciTech Connect

    Huddart, Robert A.; Hall, Emma; Hussain, Syed A.; Jenkins, Peter; Rawlings, Christine; Tremlett, Jean; Crundwell, Malcolm; Adab, Fawzi A.; Sheehan, Denise; Syndikus, Isabel; Hendron, Carey; Lewis, Rebecca; Waters, Rachel; James, Nicholas D.

    2013-10-01

    Purpose: To test whether reducing radiation dose to uninvolved bladder while maintaining dose to the tumor would reduce side effects without impairing local control in the treatment of muscle-invasive bladder cancer. Methods and Materials: In this phase III multicenter trial, 219 patients were randomized to standard whole-bladder radiation therapy (sRT) or reduced high-dose volume radiation therapy (RHDVRT) that aimed to deliver full radiation dose to the tumor and 80% of maximum dose to the uninvolved bladder. Participants were also randomly assigned to receive radiation therapy alone or radiation therapy plus chemotherapy in a partial 2 × 2 factorial design. The primary endpoints for the radiation therapy volume comparison were late toxicity and time to locoregional recurrence (with a noninferiority margin of 10% at 2 years). Results: Overall incidence of late toxicity was less than predicted, with a cumulative 2-year Radiation Therapy Oncology Group grade 3/4 toxicity rate of 13% (95% confidence interval 8%, 20%) and no statistically significant differences between groups. The difference in 2-year locoregional recurrence free rate (RHDVRT − sRT) was 6.4% (95% confidence interval −7.3%, 16.8%) under an intention to treat analysis and 2.6% (−12.8%, 14.6%) in the “per-protocol” population. Conclusions: In this study RHDVRT did not result in a statistically significant reduction in late side effects compared with sRT, and noninferiority of locoregional control could not be concluded formally. However, overall low rates of clinically significant toxicity combined with low rates of invasive bladder cancer relapse confirm that (chemo)radiation therapy is a valid option for the treatment of muscle-invasive bladder cancer.

  12. Three-dimensional structure of brain tissue at submicrometer resolution

    NASA Astrophysics Data System (ADS)

    Saiga, Rino; Mizutani, Ryuta; Inomoto, Chie; Takekoshi, Susumu; Nakamura, Naoya; Tsuboi, Akio; Osawa, Motoki; Arai, Makoto; Oshima, Kenichi; Itokawa, Masanari; Uesugi, Kentaro; Takeuchi, Akihisa; Terada, Yasuko; Suzuki, Yoshio

    2016-01-01

    Biological objects are composed of submicrometer structures such as cells and organelles that are essential for their functions. Here, we report on three-dimensional X-ray visualization of cells and organelles at resolutions up to 100 nm by imaging microtomography (micro-CT) equipped with Fresnel zone plate optics. Human cerebral tissue, fruit fly cephalic ganglia, and Escherichia coli bacteria labeled with high atomic-number elements were embedded in epoxy resin and subjected to X-ray microtomography at the BL37XU and BL47XU beamlines of the SPring-8 synchrotron radiation facility. The obtained results indicated that soft tissue structures can be visualized with the imaging microtomography.

  13. Genome Resequencing Identifies Unique Adaptations of Tibetan Chickens to Hypoxia and High-Dose Ultraviolet Radiation in High-Altitude Environments

    PubMed Central

    Zhang, Qian; Gou, Wenyu; Wang, Xiaotong; Zhang, Yawen; Ma, Jun; Zhang, Hongliang; Zhang, Ying; Zhang, Hao

    2016-01-01

    Tibetan chicken, unlike their lowland counterparts, exhibit specific adaptations to high-altitude conditions. The genetic mechanisms of such adaptations in highland chickens were determined by resequencing the genomes of four highland (Tibetan and Lhasa White) and four lowland (White Leghorn, Lindian, and Chahua) chicken populations. Our results showed an evident genetic admixture in Tibetan chickens, suggesting a history of introgression from lowland gene pools. Genes showing positive selection in highland populations were related to cardiovascular and respiratory system development, DNA repair, response to radiation, inflammation, and immune responses, indicating a strong adaptation to oxygen scarcity and high-intensity solar radiation. The distribution of allele frequencies of nonsynonymous single nucleotide polymorphisms between highland and lowland populations was analyzed using chi-square test, which showed that several differentially distributed genes with missense mutations were enriched in several functional categories, especially in blood vessel development and adaptations to hypoxia and intense radiation. RNA sequencing revealed that several differentially expressed genes were enriched in gene ontology terms related to blood vessel and respiratory system development. Several candidate genes involved in the development of cardiorespiratory system (FGFR1, CTGF, ADAM9, JPH2, SATB1, BMP4, LOX, LPR, ANGPTL4, and HYAL1), inflammation and immune responses (AIRE, MYO1F, ZAP70, DDX60, CCL19, CD47, JSC, and FAS), DNA repair, and responses to radiation (VCP, ASH2L, and FANCG) were identified to play key roles in the adaptation to high-altitude conditions. Our data provide new insights into the unique adaptations of highland animals to extreme environments. PMID:26907498

  14. Improved survival rate in primary intracranial lymphoma treated by high-dose radiation and systemic vincristine-doxorubicin-cyclophosphamide-prednisolone chemotherapy.

    PubMed

    Shibamoto, Y; Tsutsui, K; Dodo, Y; Yamabe, H; Shima, N; Abe, M

    1990-05-01

    Thirty patients with histologically proven primary intracranial non-Hodgkin's lymphoma were treated at Kyoto University. Ten of them were treated prospectively with a radiation-chemotherapy protocol. All but four specimens were recently reexamined and classified according to the Working Formulation system. The predominant histologic types were diffuse large cell type, large cell immunoblastic type, and diffuse mixed small and large cell type, seen in 38%, 21%, and 21% of cases, respectively. Before 1980, 16 patients were treated with postoperative radiation without definite chemotherapy, and only one has survived more than 5 years. Local recurrence was the most common cause of failure. In 1981, the authors started a protocol in which four to six courses of systemic chemotherapy with vincristine, doxorubicin, cyclophosphamide, and prednisolone (VEPA) was given after whole brain radiation (30-40 Gy) with a local boost up to 50 to 60 Gy. Eight patients completed this protocol, and all of them are alive at 16 to 100 months after diagnosis, with three patients surviving more than 5 years. Only one patient developed recurrence. On the other hand, six patients who did not complete or receive chemotherapy after 1981 are dead or alive with recurrence. Correlation between the Working Formulation subtype and prognosis was not clear because of the variety of treatment. Two patients receiving chemotherapy developed brain necrosis, which was fatal in one case, and the other two patients treated with the protocol are in a poor state without signs of recurrence. Chemotherapy may enhance the radiation effect on normal brain tissue as well as tumor. Combination of radiotherapy and chemotherapy can improve the survival rate, but the optimal dosage needs to be investigated further.

  15. Adjuvant Chemoradiation for Gastric Cancer Using Epirubicin, Cisplatin, and 5-Fluorouracil Before and After Three-Dimensional Conformal Radiotherapy With Concurrent Infusional 5-Fluorouracil: A Multicenter Study of the Trans-Tasman Radiation Oncology Group

    SciTech Connect

    Leong, Trevor; Joon, Daryl Lim; Willis, David; Jayamoham, Jayasingham; Spry, Nigel; Harvey, Jennifer; Di Iulio, Juliana; Milner, Alvin; Mann, G. Bruce; Michael, Michael

    2011-03-01

    Purpose: The INT0116 study has established postoperative chemoradiotherapy as the standard of care for completely resected gastric adenocarcinoma. However, the optimal chemoradiation regimen remains to be defined. We conducted a prospective, multicenter study to evaluate an alternative chemoradiation regimen that combines more current systemic treatment with modern techniques of radiotherapy delivery. Methods and Materials: Patients with adenocarcinoma of the stomach who had undergone an R0 resection were eligible. Adjuvant therapy consisted of one cycle of epirubicin, cisplatin, and 5-FU (ECF), followed by radiotherapy with concurrent infusional 5-FU, and then two additional cycles of ECF. Radiotherapy was delivered using precisely defined, multiple-field, three-dimensional conformal techniques. Results: A total of 54 assessable patients were enrolled from 19 institutions. The proportion of patients commencing Cycles 1, 2, and 3 of ECF chemotherapy were 100%, 81%, and 67% respectively. In all, 94% of patients who received radiotherapy completed treatment as planned. Grade 3/4 neutropenia occurred in 66% of patients with 7.4% developing febrile neutropenia. Most neutropenic episodes (83%) occurred in the post-radiotherapy period during cycles 2 and 3 of ECF. Grade 3/4 gastrointestinal toxicity occurred in 28% of patients. In all, 35% of radiotherapy treatment plans contained protocol deviations that were satisfactorily amended before commencement of treatment. At median follow-up of 36 months, the 3-year overall survival rate was estimated at 61.6%. Conclusions: This adjuvant regimen using ECF before and after three-dimensional conformal chemoradiation is feasible and can be safely delivered in a cooperative group setting. A regimen similar to this is currently being compared with the INT0116 regimen in a National Cancer Institute-sponsored, randomized Phase III trial.

  16. S-Nitrosylation in Organs of Mice Exposed to Low or High Doses of γ-Rays: The Modulating Effect of Iodine Contrast Agent at a Low Radiation Dose

    PubMed Central

    Nicolas, Fadia; Wu, Changgong; Bukhari, Salwa; de Toledo, Sonia M.; Li, Hong; Shibata, Masayuki; Azzam, Edouard I.

    2015-01-01

    The covalent addition of nitric oxide (NO•) onto cysteine thiols, or S-nitrosylation, modulates the activity of key signaling proteins. The dysregulation of normal S-nitrosylation contributes to degenerative conditions and to cancer. To gain insight into the biochemical changes induced by low-dose ionizing radiation, we determined global S-nitrosylation by the “biotin switch” assay coupled with mass spectrometry analyses in organs of C57BL/6J mice exposed to acute 0.1 Gy of 137Cs γ-rays. The dose of radiation was delivered to the whole body in the presence or absence of iopamidol, an iodinated contrast agent used during radiological examinations. To investigate whether similar or distinct nitrosylation patterns are induced following high-dose irradiation, mice were exposed in parallel to acute 4 Gy of 137Cs γ rays. Analysis of modulated S-nitrosothiols (SNO-proteins) in freshly-harvested organs of animals sacrificed 13 days after irradiation revealed radiation dose- and contrast agent-dependent changes. The major results were as follows: (i) iopamidol alone had significant effects on S-nitrosylation in brain, lung and liver; (ii) relative to the control, exposure to 0.1 Gy without iopamidol resulted in statistically-significant SNO changes in proteins that differ in molecular weight in liver, lung, brain and blood plasma; (iii) iopamidol enhanced the decrease in S-nitrosylation induced by 0.1 Gy in brain; (iv) whereas a decrease in S-nitrosylation occurred at 0.1 Gy for proteins of ~50 kDa in brain and for proteins of ~37 kDa in liver, an increase was detected at 4 Gy in both organs; (v) mass spectrometry analyses of nitrosylated proteins in brain revealed differential modulation of SNO proteins (e.g., sodium/potassium-transporting ATPase subunit beta-1; beta tubulins; ADP-ribosylation factor 5) by low- and high-dose irradiation; and (vi) ingenuity pathway analysis identified major signaling networks to be modulated, in particular the neuronal nitric oxide

  17. Three-dimensional nanoscopy of colloidal crystals.

    PubMed

    Harke, Benjamin; Ullal, Chaitanya K; Keller, Jan; Hell, Stefan W

    2008-05-01

    We demonstrate the direct three-dimensional imaging of densely packed colloidal nanostructures using stimulated emission depletion microscopy. A combination of two de-excitation patterns yields a resolution of 43 nm in the lateral and 125 nm in the axial direction and an effective focal volume that is by 126-fold smaller than that of a corresponding confocal microscope. The mapping of a model system of spheres organized by confined convective assembly unambiguously identified face-centered cubic, hexagonal close-packed, random hexagonal close-packed, and body-centered cubic structures.

  18. High resolution three-dimensional doping profiler

    DOEpatents

    Thundat, Thomas G.; Warmack, Robert J.

    1999-01-01

    A semiconductor doping profiler provides a Schottky contact at one surface and an ohmic contact at the other. While the two contacts are coupled to a power source, thereby establishing an electrical bias in the semiconductor, a localized light source illuminates the semiconductor to induce a photocurrent. The photocurrent changes in accordance with the doping characteristics of the semiconductor in the illuminated region. By changing the voltage of the power source the depth of the depletion layer can be varied to provide a three dimensional view of the local properties of the semiconductor.

  19. Three dimensional digital holographic aperture synthesis.

    PubMed

    Crouch, Stephen; Kaylor, Brant M; Barber, Zeb W; Reibel, Randy R

    2015-09-01

    Aperture synthesis techniques are applied to temporally and spatially diverse digital holograms recorded with a fast focal-plane array. Because the technique fully resolves the downrange dimension using wide-bandwidth FMCW linear-chirp waveforms, extremely high resolution three dimensional (3D) images can be obtained even at very long standoff ranges. This allows excellent 3D image formation even when targets have significant structure or discontinuities, which are typically poorly rendered with multi-baseline synthetic aperture ladar or multi-wavelength holographic aperture ladar approaches. The background for the system is described and system performance is demonstrated through both simulation and experiments. PMID:26368474

  20. Three-Dimensional Printing in Orthopedic Surgery.

    PubMed

    Eltorai, Adam E M; Nguyen, Eric; Daniels, Alan H

    2015-11-01

    Three-dimensional (3D) printing is emerging as a clinically promising technology for rapid prototyping of surgically implantable products. With this commercially available technology, computed tomography or magnetic resonance images can be used to create graspable objects from 3D reconstructed images. Models can enhance patients' understanding of their pathology and surgeon preoperative planning. Customized implants and casts can be made to match an individual's anatomy. This review outlines 3D printing, its current applications in orthopedics, and promising future directions. PMID:26558661

  1. Electrode With Porous Three-Dimensional Support

    DOEpatents

    Bernard, Patrick; Dauchier, Jean-Michel; Simonneau, Olivier

    1999-07-27

    Electrode including a paste containing particles of electrochemically active material and a conductive support consisting of a three-dimensional porous material comprising strands delimiting contiguous pores communicating via passages, characterized in that the average width L in .mu.m of said passages is related to the average diameter .O slashed. in .mu.m of said particles by the following equation, in which W and Y are dimensionless coefficients: wherein W=0.16 Y=1.69 X=202.4 .mu.m and Z=80 .mu.m

  2. Three dimensional model of the human mandible.

    PubMed

    Muftić, O; Milcić, D; Saucha, J; Carek, V

    2000-07-01

    A new biomechanical three-dimensional (3D) model for the human mandible is proposed. A simple two-dimensional model cannot explain the biomechanics of the human mandible, where muscular forces through occlusion and condylar surfaces are in a state of dynamical 3D equilibrium. All forces are resolved into components according to a selected coordinate system. The muscular forces, which during clenching act on the jaw, along with the necessary force level for chewing, also act as some kind of stabilizers of the mandibular condyles preventing dislocation and loading of nonarticular tissues.

  3. Three-dimensional echocardiography in valve disease

    PubMed Central

    COLOMBO, CHIARA; TAMBORINI, GLORIA; PEPI, MAURO; ALIMENTO, MARINA; FIORENTINI, CESARE

    2007-01-01

    This review covers the role of three-dimensional (3D) echocardiography in the diagnosis of heart valve disease. Several factors have contributed to the evolution of this technique, which is currently a simple and routine method: rapid evolution in probe and computer technologies, demonstration that 3D data sets allowed more complete and accurate evaluation of cardiac structures, emerging clinical experience indicating the strong potential particularly in valve diseases, volume and function of the two ventricle measurements and several other fields. This report will review current and future applications of 3D echocardiography in mitral, aortic and tricuspid valve diseases underlying both qualitative (morphologic) and quantitative advantages of this technique. PMID:21977273

  4. Three-dimensional flow about penguin wings

    NASA Astrophysics Data System (ADS)

    Noca, Flavio; Sudki, Bassem; Lauria, Michel

    2012-11-01

    Penguins, contrary to airborne birds, do not need to compensate for gravity. Yet, the kinematics of their wings is highly three-dimensional and seems exceedingly complex for plain swimming. Is such kinematics the result of an evolutionary optimization or is it just a forced adaptation of an airborne flying apparatus to underwater swimming? Some answers will be provided based on flow dynamics around robotic penguin wings. Updates will also be presented on the development of a novel robotic arm intended to simulate penguin swimming and enable novel propulsion devices.

  5. Value of Combined PET/CT for Radiation Planning in CT-Guided Percutaneous Interstitial High-Dose-Rate Single-Fraction Brachytherapy for Colorectal Liver Metastases

    SciTech Connect

    Steffen, Ingo G.; Wust, Peter; Ruehl, Ricarda

    2010-07-15

    Purpose: To determine the additional value of fluorodeoxyglucose-positron emission tomography (PET) for clinical target volume definition in the planning of computed tomography (CT)-guided interstitial brachytherapy for liver metastases. Patients and Methods: A total of 19 patients with liver metastases from colorectal cancer treated in 25 sessions were included in the present study. All patients had undergone fluorodeoxyglucose-PET for patient evaluation before interstitial CT-guided brachytherapy. A contrast-enhanced CT scan of the upper abdomen was obtained for radiation planning. The clinical target volume (CTV) was defined by a radiation oncologist and radiologist. After registration of the CT scan with the PET data set, the target volume was defined again using the fusion images. Results: PET revealed one additional liver lesion that was not visible on CT. The median CT-CTV (defined using CT and magnetic resonance imaging) was 68 cm{sup 3} (range 4-260). The PET/CT-CTV (median, 78 cm{sup 3}; range, 4-273) was significantly larger, with a median gain of 24.5% (interquartile range, 2.1-71.5%; p = .022). An increased CTV was observed in 15 cases and a decrease in 6; in 4 cases, the CT-CTV and PET/CT-CTV were equal. Incomplete dose coverage of PET/CT-CTVs was indicative of early local progression (p = .004); however, CT-based radiation plans did not show significant differences in the local control rates when stratified by dose coverage. Conclusion: Retrospective implementation of fluorodeoxyglucose-PET for CTV specification for CT-guided brachytherapy for colorectal liver metastases revealed a significant change in the CTVs. Additional PET-positive tumor regions with incomplete dose coverage could explain unexpected early local progression.

  6. Comparison of F ratios generated from interphase and metaphase chromosome damage induced by high doses of low- and high-LET radiation

    NASA Technical Reports Server (NTRS)

    Wu, H.; George, K.; Willingham, V.; Kawata, T.; Cucinotta, F. A.

    2001-01-01

    Although biophysical models predict a difference in the ratio of interchromosomal to intrachromosomal interarm exchanges (F ratio) for low- and high-LET radiations, few experimental data support this prediction. However, the F ratios in experiments to date have been generated using data on chromosome aberrations in samples collected at the first postirradiation mitosis, which may not be indicative of the aberrations formed in interphase after exposure to high-LET radiations. In the present study, we exposed human lymphocytes in vitro to 2 and 5 Gy of gamma rays and 3 Gy of 1 GeV/nucleon iron ions (LET = 140 keV/micrometer), stimulated the cells to grow with phytohemagglutinin (PHA), and collected the condensed chromosomes after 48 h of incubation using both chemically induced premature chromosome condensation (PCC) and the conventional metaphase techniques. The PCC technique used here condenses chromosomes mostly in the G(2) phase of the cell cycle. The F ratio was calculated using data on asymmetrical chromosome aberrations in both the PCC and metaphase samples. It was found that the F ratios were similar for the samples irradiated with low- and high-LET radiation and collected at metaphase. However, for irradiated samples assayed by PCC, the F ratio was found to be 8.2 +/- 2.0 for 5 Gy gamma rays and 5.2 +/- 0.9 for 3 Gy iron ions. The distribution of the aberrations indicated that, in the PCC samples irradiated with iron ions, most of the centric rings occurred in spreads containing five or more asymmetrical aberrations. These heavily damaged cells, which were either less likely to reach mitosis or may reach mitosis at a later time, were responsible for the difference in the F ratios generated from interphase and metaphase analysis after exposure to iron ions.

  7. High-Dose 131I-Tositumomab (Anti-CD20) Radioimmunotherapy for Non-Hodgkin's Lymphoma: Adjusting Radiation Absorbed Dose to Actual Organ Volumes

    SciTech Connect

    Rajendran, Joseph G.; Fisher, Darrell R.; Gopal, A K.; Durack, L. D.; Press, O. W.; Eary, Janet F.

    2004-06-01

    Radioimmunotherapy (RIT) using 131I-tositumomab has been used successfully to treat relapsed or refractory B-cell non-Hodgin's lymphoma (NHL). Our approach to treatment planning has been to determine limits on radiation absorbed close to critical nonhematopoietic organs. This study demonstrates the feasibility of using CT to adjust for actual organ volumes in calculating organ-specific absorbed dose estimates. Methods: Records of 84 patients who underwent biodistribution studies after a trace-labeled infusion of 131I-tositumomab for RIT (January 1990 and April 2003) were reviewed. Serial planar -camera images and whole-body Nal probe counts were obtained to estimate 131I-antibody source-organ residence times as recommended by the MIRD Committee. The source-organ residence times for standard man or woman were adjusted by the ratio of the MIRD phantom organ mass to the CT-derived organ mass. Results: The mean radiation absorbed doses (in mGy/MBq) for our data using the MIRD model were lungs= 1.67; liver= 1.03; kidneys= 1.08; spleen= 2.67; and whole body= 0.3; and for CT volume-adjusted organ volumes (in mGy/MBq) were lungs= 1.30; liver= 0.92; kidneys= 0.76; spleen= 1.40; and whole body= 0.22. We determined the following correlation coefficients between the 2 methods for the various organs; lungs, 0.49; (P= 0.0001); liver, 0.64 (P= 0.004); kidneys, 0.45 (P= 0.0001), for the residence times. For therapy, patients received mean 131I administered activities of 19.2 GBq (520 mCi) after adjustment for CT-derived organ mass compared with 16.0 GBq (433 mCi) that would otherwise have been given had therapy been based only using standard MIRD organ volumes--a statistically significant difference (P= 0.0001). Conclusion: We observed large variations in organ masses among our patients. Our treatments were planned to deliver the maximally tolerated radiation dose to the dose-limiting normal organ. This work provides a simplified method for calculating patient-specific radiation

  8. Three-dimensional television: a broadcaster's perspective

    NASA Astrophysics Data System (ADS)

    Jolly, S. J. E.; Armstrong, M.; Salmon, R. A.

    2009-02-01

    The recent resurgence of interest in the stereoscopic cinema and the increasing availability to the consumer of stereoscopic televisions and computer displays are leading broadcasters to consider, once again, the feasibility of stereoscopic broadcasting. High Definition Television is now widely deployed, and the R&D departments of broadcasters and consumer electronics manufacturers are starting to plan future enhancements to the experience of television. Improving the perception of depth via stereoscopy is a strong candidate technology. In this paper we will consider the challenges associated with the production, transmission and display of different forms of "three-dimensional" television. We will explore options available to a broadcaster wishing to start a 3D service using the technologies available at the present time, and consider how they could be improved to enable many more television programmes to be recorded and transmitted in a 3D-compatible form, paying particular attention to scenarios such as live broadcasting, where the workflows developed for the stereoscopic cinema are inapplicable. We will also consider the opportunities available for broadcasters to reach audiences with "three-dimensional" content via other media in the near future: for example, distributing content via the existing stereoscopic cinema network, or over the Internet to owners of stereoscopic computer displays.

  9. Three-dimensional turbopump flowfield analysis

    NASA Technical Reports Server (NTRS)

    Sharma, O. P.; Belford, K. A.; Ni, R. H.

    1992-01-01

    A program was conducted to develop a flow prediction method applicable to rocket turbopumps. The complex nature of a flowfield in turbopumps is described and examples of flowfields are discussed to illustrate that physics based models and analytical calculation procedures based on computational fluid dynamics (CFD) are needed to develop reliable design procedures for turbopumps. A CFD code developed at NASA ARC was used as the base code. The turbulence model and boundary conditions in the base code were modified, respectively, to: (1) compute transitional flows and account for extra rates of strain, e.g., rotation; and (2) compute surface heat transfer coefficients and allow computation through multistage turbomachines. Benchmark quality data from two and three-dimensional cascades were used to verify the code. The predictive capabilities of the present CFD code were demonstrated by computing the flow through a radial impeller and a multistage axial flow turbine. Results of the program indicate that the present code operated in a two-dimensional mode is a cost effective alternative to full three-dimensional calculations, and that it permits realistic predictions of unsteady loadings and losses for multistage machines.

  10. Three-dimensional flow in Kupffer's Vesicle.

    PubMed

    Montenegro-Johnson, T D; Baker, D I; Smith, D J; Lopes, S S

    2016-09-01

    Whilst many vertebrates appear externally left-right symmetric, the arrangement of internal organs is asymmetric. In zebrafish, the breaking of left-right symmetry is organised by Kupffer's Vesicle (KV): an approximately spherical, fluid-filled structure that begins to form in the embryo 10 hours post fertilisation. A crucial component of zebrafish symmetry breaking is the establishment of a cilia-driven fluid flow within KV. However, it is still unclear (a) how dorsal, ventral and equatorial cilia contribute to the global vortical flow, and (b) if this flow breaks left-right symmetry through mechanical transduction or morphogen transport. Fully answering these questions requires knowledge of the three-dimensional flow patterns within KV, which have not been quantified in previous work. In this study, we calculate and analyse the three-dimensional flow in KV. We consider flow from both individual and groups of cilia, and (a) find anticlockwise flow can arise purely from excess of cilia on the dorsal roof over the ventral floor, showing how this vortical flow is stabilised by dorsal tilt of equatorial cilia, and (b) show that anterior clustering of dorsal cilia leads to around 40 % faster flow in the anterior over the posterior corner. We argue that these flow features are supportive of symmetry breaking through mechano-sensory cilia, and suggest a novel experiment to test this hypothesis. From our new understanding of the flow, we propose a further experiment to reverse the flow within KV to potentially induce situs inversus.

  11. Three-dimensional fluorescence lifetime tomography

    SciTech Connect

    Godavarty, Anuradha; Sevick-Muraca, Eva M.; Eppstein, Margaret J.

    2005-04-01

    Near-infrared fluorescence tomography using molecularly targeted lifetime-sensitive, fluorescent contrast agents have applications for early-stage cancer diagnostics. Yet, although the measurement of fluorescent lifetime imaging microscopy (FLIM) is extensively used in microscopy and spectroscopy applications, demonstration of fluorescence lifetime tomography for medical imaging is limited to two-dimensional studies. Herein, the feasibility of three-dimensional fluorescence-lifetime tomography on clinically relevant phantom volumes is established, using (i) a gain-modulated intensified charge coupled device (CCD) and modulated laser diode imaging system, (ii) two fluorescent contrast agents, e.g., Indocyanine green and 3-3'-Diethylthiatricarbocyanine iodide differing in their fluorescence lifetime by 0.62 ns, and (iii) a two stage approximate extended Kalman filter reconstruction algorithm. Fluorescence measurements of phase and amplitude were acquired on the phantom surface under different target to background fluorescence absorption (70:1, 100:1) and fluorescence lifetime (1:1, 2.1:1) contrasts at target depths of 1.4-2 cm. The Bayesian tomography algorithm was employed to obtain three-dimensional images of lifetime and absorption owing to the fluorophores.

  12. Three-dimensional head anthropometric analysis

    NASA Astrophysics Data System (ADS)

    Enciso, Reyes; Shaw, Alex M.; Neumann, Ulrich; Mah, James

    2003-05-01

    Currently, two-dimensional photographs are most commonly used to facilitate visualization, assessment and treatment of facial abnormalities in craniofacial care but are subject to errors because of perspective, projection, lack metric and 3-dimensional information. One can find in the literature a variety of methods to generate 3-dimensional facial images such as laser scans, stereo-photogrammetry, infrared imaging and even CT however each of these methods contain inherent limitations and as such no systems are in common clinical use. In this paper we will focus on development of indirect 3-dimensional landmark location and measurement of facial soft-tissue with light-based techniques. In this paper we will statistically evaluate and validate a current three-dimensional image-based face modeling technique using a plaster head model. We will also develop computer graphics tools for indirect anthropometric measurements in a three-dimensional head model (or polygonal mesh) including linear distances currently used in anthropometry. The measurements will be tested against a validated 3-dimensional digitizer (MicroScribe 3DX).

  13. In-lab three-dimensional printing

    PubMed Central

    Partridge, Roland; Conlisk, Noel; Davies, Jamie A.

    2012-01-01

    The development of the microscope in 1590 by Zacharias Janssenby and Hans Lippershey gave the world a new way of visualizing details of morphogenesis and development. More recent improvements in this technology including confocal microscopy, scanning electron microscopy (SEM) and optical projection tomography (OPT) have enhanced the quality of the resultant image. These technologies also allow a representation to be made of a developing tissue’s three-dimensional (3-D) form. With all these techniques however, the image is delivered on a flat two-dimensional (2-D) screen. 3-D printing represents an exciting potential to reproduce the image not simply on a flat screen, but in a physical, palpable three-dimensional structure. Here we explore the scope that this holds for exploring and interacting with the structure of a developing organ in an entirely novel way. As well as being useful for visualization, 3-D printers are capable of rapidly and cost-effectively producing custom-made structures for use within the laboratory. We here describe the advantages of producing hardware for a tissue culture system using an inexpensive in-lab printer. PMID:22652907

  14. Three-dimensional model of lignin structure

    SciTech Connect

    Jurasek, L.

    1995-12-01

    An attempt to build a three-dimensional model of lignin structure using a computer program is described. The program simulates the biosynthesis of spruce lignin by allowing coniferyl alcohol subunits to be added randomly by six different types of linkages, assumed to be most common. The simulated biosynthesis starts from a number of seed points within restricted space, corresponding to 50 mM initial concentration of coniferyl alcohol. Rules of three-dimensional packing of the subunits within the lignin macro-molecule are observed during the simulated biosynthetic process. Branched oligomeric structures thus generated form crosslinks at those positions where the chains grow close enough to form a link. Inter-chain crosslinking usually joins the oligomers into one macromolecule. Intra-chain crosslinks are also formed and result in closed loops. Typically, a macromolecule with molecular weight of approx. 2 x 105 is formed, with internal density of 1.35g/cm3. Various characteristics of the internal structure, such as branching, crosslinking, bond frequencies, and chain length distribution are described. Breakdown of the polymer was also simulated and the effect of closed loops on the weight average molecular weight is shown. The effect of the shape of the biosynthetic space on the degree of crosslinking is discussed and predictions of the overall molecular shape of lignin particles are made.

  15. Nanowired three-dimensional cardiac patches

    NASA Astrophysics Data System (ADS)

    Dvir, Tal; Timko, Brian P.; Brigham, Mark D.; Naik, Shreesh R.; Karajanagi, Sandeep S.; Levy, Oren; Jin, Hongwei; Parker, Kevin K.; Langer, Robert; Kohane, Daniel S.

    2011-11-01

    Engineered cardiac patches for treating damaged heart tissues after a heart attack are normally produced by seeding heart cells within three-dimensional porous biomaterial scaffolds. These biomaterials, which are usually made of either biological polymers such as alginate or synthetic polymers such as poly(lactic acid) (PLA), help cells organize into functioning tissues, but poor conductivity of these materials limits the ability of the patch to contract strongly as a unit. Here, we show that incorporating gold nanowires within alginate scaffolds can bridge the electrically resistant pore walls of alginate and improve electrical communication between adjacent cardiac cells. Tissues grown on these composite matrices were thicker and better aligned than those grown on pristine alginate and when electrically stimulated, the cells in these tissues contracted synchronously. Furthermore, higher levels of the proteins involved in muscle contraction and electrical coupling are detected in the composite matrices. It is expected that the integration of conducting nanowires within three-dimensional scaffolds may improve the therapeutic value of current cardiac patches.

  16. Two component-three dimensional catalysis

    DOEpatents

    Schwartz, Michael; White, James H.; Sammells, Anthony F.

    2002-01-01

    This invention relates to catalytic reactor membranes having a gas-impermeable membrane for transport of oxygen anions. The membrane has an oxidation surface and a reduction surface. The membrane is coated on its oxidation surface with an adherent catalyst layer and is optionally coated on its reduction surface with a catalyst that promotes reduction of an oxygen-containing species (e.g., O.sub.2, NO.sub.2, SO.sub.2, etc.) to generate oxygen anions on the membrane. The reactor has an oxidation zone and a reduction zone separated by the membrane. A component of an oxygen containing gas in the reduction zone is reduced at the membrane and a reduced species in a reactant gas in the oxidation zone of the reactor is oxidized. The reactor optionally contains a three-dimensional catalyst in the oxidation zone. The adherent catalyst layer and the three-dimensional catalyst are selected to promote a desired oxidation reaction, particularly a partial oxidation of a hydrocarbon.

  17. Three-dimensional strain analysis using Mathematica

    NASA Astrophysics Data System (ADS)

    Mookerjee, Matty; Nickleach, Scott

    2011-10-01

    A suite of geological computer programs written in Mathematica is currently available both within the online repository for the Journal of Structural Geology as well as on the first author's website ( http://www.sonoma.edu/users/m/mookerje/ProgramPage.htm). The majority of these programs focus on three-dimensional strain analysis (e.g., determining best-fit strain ellipsoids, plotting elliptical data on either a Flinn or Hsu diagram, and determining error bounds for three-dimensional strain data). This program suite also includes a ternary diagram plotting program, a rose diagram program, an equal area and equal angle projections program, and an instructional program for creating two-dimensional strain path animations. The bulk of this paper focuses on a new method for determining a best-fit ellipsoid from arbitrarily oriented sectional ellipses and methods for determining appropriate error bounds for strain parameters and orientation data. This best-fit ellipsoid method utilizes a least-squares approach and minimizes the error associated with the two-dimensional data-ellipse matrix elements with the corresponding matrix elements from sectional ellipses through a general ellipsoid. Furthermore, a kernel density estimator is utilized to yield reliable error margins for the strain parameters, octahedral shear strain, Flinn's k-value, and Lode's ratio. By assuming a gamma distribution for the simulated principal axes orientations, more realistic error bounds can be estimated for these axes orientations.

  18. Simulating Titan's Aerosols in a Three Dimensional GCM

    NASA Astrophysics Data System (ADS)

    Larson, E.; Toon, O.; Friedson, A.; West, R.

    2011-10-01

    We present the results of a coupled three dimensional global climate model (GCM) and aerosol microphsyics model to elucidate properties of the aerosols and their radiative effects on the atmosphere. In particular, we are interested in determining the size, number density, aerosol charging, and production rate of the aerosols. The values along with DISR derived indices of refraction allow us to retrieve optical depths and extinctions at all latitudes and seasons. We couple these aerosols to the radiative transfer code and see the effects on the heating rate and temperatures. These coupled aerosols also have dynamical feedbacks. Our model also allows us to study the historical albedo seasonal cycle from a microphysics perspective. We compare these properties with spacecraft and ground based data and use them to constrain the model.

  19. External-Beam Radiation Therapy and High-Dose Rate Brachytherapy Combined With Long-Term Androgen Deprivation Therapy in High and Very High Prostate Cancer: Preliminary Data on Clinical Outcome

    SciTech Connect

    Martinez-Monge, Rafael; Moreno, Marta; Ciervide, Raquel; Cambeiro, Mauricio; Perez-Gracia, Jose Luis; Gil-Bazo, Ignacio; Gaztanaga, Miren; Arbea, Leire; Pascual, Ignacio; Aristu, Javier

    2012-03-01

    Purpose: To determine the feasibility of combined long-term androgen deprivation therapy (ADT) and dose escalation with high-dose-rate (HDR) brachytherapy. Methods and Materials: Between 2001 and 2007, 200 patients with high-risk prostate cancer (32.5%) or very high-risk prostate cancer (67.5%) were prospectively enrolled in this Phase II trial. Tumor characteristics included a median pretreatment prostate-specific antigen of 15.2 ng/mL, a clinical stage of T2c, and a Gleason score of 7. Treatment consisted of 54 Gy of external irradiation (three-dimensional conformal radiotherapy [3DCRT]) followed by 19 Gy of HDR brachytherapy in four twice-daily treatments. ADT started 0-3 months before 3DCRT and continued for 2 years. Results: One hundred and ninety patients (95%) received 2 years of ADT. After a median follow-up of 3.7 years (range, 2-9), late Grade {>=}2 urinary toxicity was observed in 18% of the patients and Grade {>=}3 was observed in 5%. Prior transurethral resection of the prostate (p = 0.013) and bladder D{sub 50} {>=}1.19 Gy (p = 0.014) were associated with increased Grade {>=}2 urinary complications; age {>=}70 (p = 0.05) was associated with Grade {>=}3 urinary complications. Late Grade {>=}2 gastrointestinal toxicity was observed in 9% of the patients and Grade {>=}3 in 1.5%. CTV size {>=}35.8 cc (p = 0.007) and D{sub 100} {>=}3.05 Gy (p = 0.01) were significant for increased Grade {>=}2 complications. The 5-year and 9-year biochemical relapse-free survival (nadir + 2) rates were 85.1% and 75.7%, respectively. Patients with Gleason score of 7-10 had a decreased biochemical relapse-free survival (p = 0.007). Conclusions: Intermediate-term results at the 5-year time point indicate a favorable outcome without an increase in the rate of late complications.

  20. Automatic three-dimensional underground mine mapping

    SciTech Connect

    Huber, D.F.; Vandapel, N.

    2006-01-15

    For several years, our research group has been developing methods for automated modeling of three-dimensional environments. In September 2002, we were given the opportunity to demonstrate our mapping capability in an underground coal mine. The opportunity arose as a result of the Quecreek mine accident, in which an inaccurate map caused miners to breach an abandoned, water-filled mine, trapping them for several days. Our field test illustrates the feasibility and potential of high-resolution 3D mapping of an underground coal mine using a cart-mounted 3D laser scanner In this paper we present our experimental setup, the automatic 3D modeling method used, and the results of the field test.

  1. Three-dimensional hologram display system

    NASA Technical Reports Server (NTRS)

    Mintz, Frederick (Inventor); Chao, Tien-Hsin (Inventor); Bryant, Nevin (Inventor); Tsou, Peter (Inventor)

    2009-01-01

    The present invention relates to a three-dimensional (3D) hologram display system. The 3D hologram display system includes a projector device for projecting an image upon a display medium to form a 3D hologram. The 3D hologram is formed such that a viewer can view the holographic image from multiple angles up to 360 degrees. Multiple display media are described, namely a spinning diffusive screen, a circular diffuser screen, and an aerogel. The spinning diffusive screen utilizes spatial light modulators to control the image such that the 3D image is displayed on the rotating screen in a time-multiplexing manner. The circular diffuser screen includes multiple, simultaneously-operated projectors to project the image onto the circular diffuser screen from a plurality of locations, thereby forming the 3D image. The aerogel can use the projection device described as applicable to either the spinning diffusive screen or the circular diffuser screen.

  2. Three-dimensional printing physiology laboratory technology.

    PubMed

    Sulkin, Matthew S; Widder, Emily; Shao, Connie; Holzem, Katherine M; Gloschat, Christopher; Gutbrod, Sarah R; Efimov, Igor R

    2013-12-01

    Since its inception in 19th-century Germany, the physiology laboratory has been a complex and expensive research enterprise involving experts in various fields of science and engineering. Physiology research has been critically dependent on cutting-edge technological support of mechanical, electrical, optical, and more recently computer engineers. Evolution of modern experimental equipment is constrained by lack of direct communication between the physiological community and industry producing this equipment. Fortunately, recent advances in open source technologies, including three-dimensional printing, open source hardware and software, present an exciting opportunity to bring the design and development of research instrumentation to the end user, i.e., life scientists. Here we provide an overview on how to develop customized, cost-effective experimental equipment for physiology laboratories.

  3. Numerical simulation of three dimensional transonic flows

    NASA Technical Reports Server (NTRS)

    Sahu, Jubaraj; Steger, Joseph L.

    1987-01-01

    The three-dimensional flow over a projectile has been computed using an implicit, approximately factored, partially flux-split algorithm. A simple composite grid scheme has been developed in which a single grid is partitioned into a series of smaller grids for applications which require an external large memory device such as the SSD of the CRAY X-MP/48, or multitasking. The accuracy and stability of the composite grid scheme has been tested by numerically simulating the flow over an ellipsoid at angle of attack and comparing the solution with a single grid solution. The flowfield over a projectile at M = 0.96 and 4 deg angle-of-attack has been computed using a fine grid, and compared with experiment.

  4. Three dimensional fabric evolution of sheared sand

    SciTech Connect

    Hasan, Alsidqi; Alshibli, Khalid

    2012-10-24

    Granular particles undergo translation and rolling when they are sheared. This paper presents a three-dimensional (3D) experimental assessment of fabric evolution of sheared sand at the particle level. F-75 Ottawa sand specimen was tested under an axisymmetric triaxial loading condition. It measured 9.5 mm in diameter and 20 mm in height. The quantitative evaluation was conducted by analyzing 3D high-resolution x-ray synchrotron micro-tomography images of the specimen at eight axial strain levels. The analyses included visualization of particle translation and rotation, and quantification of fabric orientation as shearing continued. Representative individual particles were successfully tracked and visualized to assess the mode of interaction between them. This paper discusses fabric evolution and compares the evolution of particles within and outside the shear band as shearing continues. Changes in particle orientation distributions are presented using fabric histograms and fabric tensor.

  5. Scaffolding for Three-Dimensional Embryonic Vasculogenesis

    NASA Astrophysics Data System (ADS)

    Kraehenbuehl, Thomas P.; Aday, Sezin; Ferreira, Lino S.

    Biomaterial scaffolds have great potential to support efficient vascular differentiation of embryonic stem cells. Vascular cell fate-specific biochemical and biophysical cues have been identified and incorporated into three-dimensional (3D) biomaterials to efficiently direct embryonic vasculogenesis. The resulting vascular-like tissue can be used for regenerative medicine applications, further elucidation of biophysical and biochemical cues governing vasculogenesis, and drug discovery. In this chapter, we give an overview on the following: (1) developmental cues for directed differentiation of human embryonic stem cells (hESCs) into vascular cells, (2) 3D vascular differentiation in embryoid bodies (EBs), (3) preparation of 3D scaffolds for the vascular differentiation of hESCs, and (4) the most significant studies combining scaffolding and hESCs for development of vascular-like tissue.

  6. Three dimensional thrust chamber life prediction

    NASA Technical Reports Server (NTRS)

    Armstrong, W. H.; Brogren, E. W.

    1976-01-01

    A study was performed to analytically determine the cyclic thermomechanical behavior and fatigue life of three configurations of a Plug Nozzle Thrust Chamber. This thrust chamber is a test model which represents the current trend in nozzle design calling for high performance coupled with weight and volume limitations as well as extended life for reusability. The study involved the use of different materials and material combinations to evaluate their application to the problem of low-cycle fatigue in the thrust chamber. The thermal and structural analyses were carried out on a three-dimensional basis. Results are presented which show plots of continuous temperature histories and temperature distributions at selected times during the operating cycle of the thrust chamber. Computed structural data show critical regions for low-cycle fatigue and the histories of strain within the regions for each operation cycle.

  7. Three-dimensional comparative analysis of bitemarks.

    PubMed

    Lasser, Allan J; Warnick, Allan J; Berman, Gary M

    2009-05-01

    Historically, the inability to accurately represent bitemarks and other wound patterns has limited their evidentiary value. The development of the ABFO #2 scale by Krauss and Hyzer enabled forensic odontologists to correct for most photographic plane distortions. The technique presented here uses the ABFO #2 scale in conjunction with the evolving technologies of laser scanners and comparative software commonly used by the automobile industry for three-dimensional (3D) analysis. The 3D software comparison was performed in which measurements were analyzed of the normal distance for each point on the teeth relative to the bitemarks. It created a color-mapped display of the bitemark model, with the color indicating the deviation at each point. There was a correlation between the bitemark and the original teeth. PMID:19432742

  8. Three-dimensional tori and Arnold tongues

    SciTech Connect

    Sekikawa, Munehisa; Inaba, Naohiko; Kamiyama, Kyohei; Aihara, Kazuyuki

    2014-03-15

    This study analyzes an Arnold resonance web, which includes complicated quasi-periodic bifurcations, by conducting a Lyapunov analysis for a coupled delayed logistic map. The map can exhibit a two-dimensional invariant torus (IT), which corresponds to a three-dimensional torus in vector fields. Numerous one-dimensional invariant closed curves (ICCs), which correspond to two-dimensional tori in vector fields, exist in a very complicated but reasonable manner inside an IT-generating region. Periodic solutions emerge at the intersections of two different thin ICC-generating regions, which we call ICC-Arnold tongues, because all three independent-frequency components of the IT become rational at the intersections. Additionally, we observe a significant bifurcation structure where conventional Arnold tongues transit to ICC-Arnold tongues through a Neimark-Sacker bifurcation in the neighborhood of a quasi-periodic Hopf bifurcation (or a quasi-periodic Neimark-Sacker bifurcation) boundary.

  9. Quantum interferometry with three-dimensional geometry

    PubMed Central

    Spagnolo, Nicolò; Aparo, Lorenzo; Vitelli, Chiara; Crespi, Andrea; Ramponi, Roberta; Osellame, Roberto; Mataloni, Paolo; Sciarrino, Fabio

    2012-01-01

    Quantum interferometry uses quantum resources to improve phase estimation with respect to classical methods. Here we propose and theoretically investigate a new quantum interferometric scheme based on three-dimensional waveguide devices. These can be implemented by femtosecond laser waveguide writing, recently adopted for quantum applications. In particular, multiarm interferometers include “tritter” and “quarter” as basic elements, corresponding to the generalization of a beam splitter to a 3- and 4-port splitter, respectively. By injecting Fock states in the input ports of such interferometers, fringe patterns characterized by nonclassical visibilities are expected. This enables outperforming the quantum Fisher information obtained with classical fields in phase estimation. We also discuss the possibility of achieving the simultaneous estimation of more than one optical phase. This approach is expected to open new perspectives to quantum enhanced sensing and metrology performed in integrated photonics. PMID:23181189

  10. Towards microscale electrohydrodynamic three-dimensional printing

    NASA Astrophysics Data System (ADS)

    He, Jiankang; Xu, Fangyuan; Cao, Yi; Liu, Yaxiong; Li, Dichen

    2016-02-01

    It is challenging for the existing three-dimensional (3D) printing techniques to fabricate high-resolution 3D microstructures with low costs and high efficiency. In this work we present a solvent-based electrohydrodynamic 3D printing technique that allows fabrication of microscale structures like single walls, crossed walls, lattice and concentric circles. Process parameters were optimized to deposit tiny 3D patterns with a wall width smaller than 10 μm and a high aspect ratio of about 60. Tight bonding among neighbour layers could be achieved with a smooth lateral surface. In comparison with the existing microscale 3D printing techniques, the presented method is low-cost, highly efficient and applicable to multiple polymers. It is envisioned that this simple microscale 3D printing strategy might provide an alternative and innovative way for application in MEMS, biosensor and flexible electronics.

  11. Steady inviscid three-dimensional flows

    NASA Technical Reports Server (NTRS)

    Adamczyk, J. J.; Chang, S.-C.

    1985-01-01

    The present analysis combines some of the theoretical concepts suggested by Hawthorne (1955) with a numerical integration procedure suggested by Martin (1978). The resulting algorithm is for inviscid subsonic flows. Thus, it is restricted to high Reynolds number flows. Chang and Adamczyk (1983) have provided a detailed derivation of the present algorithm along with a discussion of its stability bounds. The present paper represents a summary of this work. The integration of the continuity equation is considered along with an evaluation of the entropy, total temperature, and vorticity field. Attention is given to the shear-flow algorithm construction, and an application to a shear flow in a turning channel. A description of numerical results is also provided. The discussed algorithm represents a new procedure for solving inviscid subsonic three-dimensional rotational flows.

  12. Three-dimensional printing physiology laboratory technology

    PubMed Central

    Sulkin, Matthew S.; Widder, Emily; Shao, Connie; Holzem, Katherine M.; Gloschat, Christopher; Gutbrod, Sarah R.

    2013-01-01

    Since its inception in 19th-century Germany, the physiology laboratory has been a complex and expensive research enterprise involving experts in various fields of science and engineering. Physiology research has been critically dependent on cutting-edge technological support of mechanical, electrical, optical, and more recently computer engineers. Evolution of modern experimental equipment is constrained by lack of direct communication between the physiological community and industry producing this equipment. Fortunately, recent advances in open source technologies, including three-dimensional printing, open source hardware and software, present an exciting opportunity to bring the design and development of research instrumentation to the end user, i.e., life scientists. Here we provide an overview on how to develop customized, cost-effective experimental equipment for physiology laboratories. PMID:24043254

  13. Three-dimensional modular electronic interconnection system

    NASA Technical Reports Server (NTRS)

    Bolotin, Gary S. (Inventor); Cardone, John (Inventor)

    2001-01-01

    A three-dimensional connection system uses a plurality of printed wiring boards with connectors completely around the printed wiring boards, and connected by an elastomeric interface connector. The device includes internal space to allow room for circuitry. The device is formed by stacking an electronics module, an elastomeric interface board on the electronics module such that the interface board's exterior makes electrical connection with the connectors around the perimeter of the interface board, but the internal portion is open to allow room for the electrical devices on the printed wiring board. A plurality of these devices are stacked between a top stiffener and a bottom device, and held into place by alignment elements.

  14. Surface fitting three-dimensional bodies

    NASA Technical Reports Server (NTRS)

    Dejarnette, F. R.; Ford, C. P., III

    1975-01-01

    The geometry of general three-dimensional bodies was generated from coordinates of points in several cross sections. Since these points may not be on smooth curves, they are divided into groups forming segments and general conic sections are curve fit in a least-squares sense to each segment of a cross section. The conic sections are then blended in the longitudinal direction through longitudinal curves. Both the cross-sectional and longitudinal curves may be modified by specifying particular segments as straight lines or specifying slopes at selected points. This method was used to surface fit a 70 deg slab delta wing and the HL-10 Lifting Body. The results for the delta wing were very close to the exact geometry. Although there is no exact solution for the lifting body, the surface fit generated a smooth surface with cross-sectional planes very close to prescribed coordinate points.

  15. Magneto Transport in Three Dimensional Carbon Nanostructures

    NASA Astrophysics Data System (ADS)

    Datta, Timir; Wang, Lei; Jaroszynski, Jan; Yin, Ming; Alameri, Dheyaa

    Electrical properties of self-assembled three dimensional nanostructures are interesting topic. Here we report temperature dependence of magneto transport in such carbon nanostructures with periodic spherical voids. Specimens with different void diameters in the temperature range from 200 mK to 20 K were studied. Above 2 K, magnetoresistance, MR = [R(B) - R(0)] / R(0), crosses over from quadratic to a linear dependence with the increase of magnetic field [Wang et al., APL 2015; DOI:10.1063/1.4926606]. We observe MR to be non-saturating even up to 18 Tesla. Furthermore, MR demonstrates universality because all experimental data can be collapsed on to a single curve, as a universal function of B/T. Below 2 K, magnetoresistance saturates with increasing field. Quantum Hall like steps are also observed in this low temperature regime. Remarkably, MR of our sample displays orientation independence, an attractive feature for technological applications.

  16. Three-dimensional cultured glioma cell lines

    NASA Technical Reports Server (NTRS)

    Gonda, Steve R. (Inventor); Marley, Garry M. (Inventor)

    1991-01-01

    Three-dimensional glioma spheroids were produced in vitro with size and histological differentiation previously unattained. The spheroids were grown in liquid media suspension in a Johnson Space Center (JSC) Rotating Wall Bioreactor without using support matrices such as microcarrier beads. Spheroid volumes of greater than 3.5 cu mm and diameters of 2.5 mm were achieved with a viable external layer or rim of proliferating cells, a transitional layer beneath the external layer with histological differentiation, and a degenerative central region with a hypoxic necrotic core. Cell debris was evident in the degenerative central region. The necrotics centers of some of the spheroids had hyaline droplets. Granular bodies were detected predominantly in the necrotic center.

  17. Masking in three-dimensional auditory displays.

    PubMed

    Doll, T J; Hanna, T E; Russotti, J S

    1992-06-01

    The extent to which simultaneous inputs in a three-dimensional (3D) auditory display mask one another was studied in a simulated sonar task. The minimum signal-to-noise ratio (SNR) required to detect an amplitude-modulated 500-Hz tone in a background of broadband noise was measured using a loudspeaker array in a free field. Three aspects of the 3D array were varied: angular separation of the sources, degree of correlation of the background noises, and listener head movement. Masking was substantially reduced when the sources were uncorrelated. The SNR needed for detection decreased with source separation, and the rate of decrease was significantly greater with uncorrelated sources than with partially or fully correlated sources. Head movement had no effect on the SNR required for detection. Implications for the design and application of 3D auditory displays are discussed.

  18. Three-dimensional tori and Arnold tongues

    NASA Astrophysics Data System (ADS)

    Sekikawa, Munehisa; Inaba, Naohiko; Kamiyama, Kyohei; Aihara, Kazuyuki

    2014-03-01

    This study analyzes an Arnold resonance web, which includes complicated quasi-periodic bifurcations, by conducting a Lyapunov analysis for a coupled delayed logistic map. The map can exhibit a two-dimensional invariant torus (IT), which corresponds to a three-dimensional torus in vector fields. Numerous one-dimensional invariant closed curves (ICCs), which correspond to two-dimensional tori in vector fields, exist in a very complicated but reasonable manner inside an IT-generating region. Periodic solutions emerge at the intersections of two different thin ICC-generating regions, which we call ICC-Arnold tongues, because all three independent-frequency components of the IT become rational at the intersections. Additionally, we observe a significant bifurcation structure where conventional Arnold tongues transit to ICC-Arnold tongues through a Neimark-Sacker bifurcation in the neighborhood of a quasi-periodic Hopf bifurcation (or a quasi-periodic Neimark-Sacker bifurcation) boundary.

  19. Three-dimensional pancreas organogenesis models.

    PubMed

    Grapin-Botton, A

    2016-09-01

    A rediscovery of three-dimensional culture has led to the development of organ biogenesis, homeostasis and disease models applicable to human tissues. The so-called organoids that have recently flourished serve as valuable models bridging between cell lines or primary cells grown on the bottom of culture plates and experiments performed in vivo. Though not recapitulating all aspects of organ physiology, the miniature organs generated in a dish are useful models emerging for the pancreas, starting from embryonic progenitors, adult cells, tumour cells and stem cells. This review focusses on the currently available systems and their relevance to the study of the pancreas, of β-cells and of several pancreatic diseases including diabetes. We discuss the expected future developments for studying human pancreas development and function, for developing diabetes models and for producing therapeutic cells. PMID:27615129

  20. The Three-Dimensional EIT Wave

    NASA Technical Reports Server (NTRS)

    Thompson, B. J.; Biesecker, D. A.; Gilbert, H. R.; Lawrence, G. R.; Ofman, L.; Wu, S. T.; Warmuth, A.; Fisher, Richard R. (Technical Monitor)

    2002-01-01

    An EIT wave is an impulsive disturbance which has been observed in the EUV, Soft X-ray and white light corona, with corresponding observations in the chromosphere. The effects of these disturbances can be observed across the entire solar disk of the Sun, and throughout the inner heliosphere as well. However, the picture is not complete; observations alone do not establish a complete understanding of the nature of this three-dimensional phenomenon. A number of associated phenomena have been documented, though in most cases causality has not determined. Additionally, it is unclear which factors govern the impulse's ability to affect regions of the corona and heliosphere. We discuss the various observations and the models which provided links between the associated phenomena.

  1. Three-Dimensional Reflectance Traction Microscopy

    PubMed Central

    Jones, Christopher A. R.; Groves, Nicholas Scott; Sun, Bo

    2016-01-01

    Cells in three-dimensional (3D) environments exhibit very different biochemical and biophysical phenotypes compared to the behavior of cells in two-dimensional (2D) environments. As an important biomechanical measurement, 2D traction force microscopy can not be directly extended into 3D cases. In order to quantitatively characterize the contraction field, we have developed 3D reflectance traction microscopy which combines confocal reflection imaging and partial volume correlation postprocessing. We have measured the deformation field of collagen gel under controlled mechanical stress. We have also characterized the deformation field generated by invasive breast cancer cells of different morphologies in 3D collagen matrix. In contrast to employ dispersed tracing particles or fluorescently-tagged matrix proteins, our methods provide a label-free, computationally effective strategy to study the cell mechanics in native 3D extracellular matrix. PMID:27304456

  2. Multiscale modeling of three-dimensional genome

    NASA Astrophysics Data System (ADS)

    Zhang, Bin; Wolynes, Peter

    The genome, the blueprint of life, contains nearly all the information needed to build and maintain an entire organism. A comprehensive understanding of the genome is of paramount interest to human health and will advance progress in many areas, including life sciences, medicine, and biotechnology. The overarching goal of my research is to understand the structure-dynamics-function relationships of the human genome. In this talk, I will be presenting our efforts in moving towards that goal, with a particular emphasis on studying the three-dimensional organization, the structure of the genome with multi-scale approaches. Specifically, I will discuss the reconstruction of genome structures at both interphase and metaphase by making use of data from chromosome conformation capture experiments. Computationally modeling of chromatin fiber at atomistic level from first principles will also be presented as our effort for studying the genome structure from bottom up.

  3. Clinical application of three-dimensional echocardiography.

    PubMed

    Morbach, Caroline; Lin, Ben A; Sugeng, Lissa

    2014-01-01

    Echocardiography is one of the most valuable diagnostic tools in cardiology. Technological advances in ultrasound, computer and electronics enables three-dimensional (3-D) imaging to be a clinically viable modality which has significant impact on diagnosis, management and interventional procedures. Since the inception of 3D fully-sampled matrix transthoracic and transesophageal technology it has enabled easier acquisition, immediate on-line display, and availability of on-line analysis for the left ventricle, right ventricle and mitral valve. The use of 3D TTE has mainly focused on mitral valve disease, left and right ventricular volume and functional analysis. As structural heart disease procedures become more prevalent, 3D TEE has become a requirement for preparation of the procedure, intra-procedural guidance as well as monitoring for complications and device function. We anticipate that there will be further software development, improvement in image quality and workflow.

  4. Three dimensional fog forecasting in complex terrain

    NASA Astrophysics Data System (ADS)

    Mueller, M.; Masbou, M.; Bott, A.

    2010-07-01

    Fog in complex terrain shows large temporal and spatial variations that can only be simulated with a three-dimensional model, but more modifications than increasing the resolution are needed. For a better representation of fog we present a second moment cloud water scheme with a parametrization of the Köhler theory which is combined with the mixed phase Ferrier microphysics scheme. The more detailed microphysics produce many differences to the first moment Ferrier scheme and are responsible for reproducing the typically low liquid water content of fog. With explicitly predicted droplet number concentrations, sedimentation of cloud water can be modeled without a prescribed fall speed, which mainly affects the vertical distribution of cloud water and the end of the fogs life cycle. The complex topography of the Swiss Alps and its surroundings are used for model testing. As the focus is on the models ability to forecast the spatial distribution of fog, cloud patterns derived from high resolution MSG satellite data, rather than few point observations from ground stations are used. In a continous five day period of anticyclonic conditions, the satellite observed fog patterns showed large day to day variations with almost no fog to large areas of fog. This variability was very well simulated in the three-dimensional fog forecast. The simulations also demonstrate the need for high horizontal resolutions between 1 and 3 km. For model initialization the complex topography is actually a simplifying factor, as cold air flow and pooling are dominating the more uncertain processes of evapotranspiration or errors in the soil moisture field.

  5. Three-dimensional image contrast using biospeckle

    NASA Astrophysics Data System (ADS)

    Godinho, Robson Pierangeli; Braga, Roberto A., Jr.

    2010-09-01

    The biospeckle laser (BSL) has been applied in many areas of knowledge and a variety of approaches has been presented to address the best results in biological and non-biological samples, in fast or slow activities, or else in defined flow of materials or in random activities. The methodologies accounted in the literature consider the apparatus used in the image assembling and the way the collected data is processed. The image processing steps presents in turn a variety of procedures with first or second order statistics analysis, and as well with different sizes of data collected. One way to access the biospeckle in defined flow, such as in capillary blood flow in alive animals, was the adoption of the image contrast technique which uses only one image from the illuminated sample. That approach presents some problems related to the resolution of the image, which is reduced during the image contrast processing. In order to help the visualization of the low resolution image formed by the contrast technique, this work presents the three-dimensional procedure as a reliable alternative to enhance the final image. The work based on a parallel processing, with the generation of a virtual map of amplitudes, and maintaining the quasi-online characteristic of the contrast technique. Therefore, it was possible to generate in the same display the observed material, the image contrast result and in addiction the three-dimensional image with adjustable options of rotation. The platform also offers to the user the possibility to access the 3D image offline.

  6. The Effect of Flattening Filter Free on Three-dimensional Conformal Radiation Therapy (3D-CRT), Intensity-Modulated Radiation Therapy (IMRT), and Volumetric Modulated Arc Therapy (VMAT) Plans for Metastatic Brain Tumors from Non-small Cell Lung Cancer.

    PubMed

    Shi, Li-Wan; Lai, You-Qun; Lin, Qin; Ha, Hui-Ming; Fu, Li-Rong

    2015-07-01

    Flattening filter free (FFF) may affect outcome measures of radiotherapy. The objective of this study is to compare the dosimetric parameters in three types of radiotherapy plans, three-dimensional conformal radiation therapy (3D-CRT), intensity-modulated radiation therapy (IMRT), and volumetric modulated arc therapy (VMAT), with or without the flattening filter (FF), developed for the treatment of metastatic brain tumors from non-small cell lung cancer (NSCLC). From July 2013 to October 2013, 3D-CRT, IMRT, and VMAT treatment plans were designed using 6 MV and 10 MV, with and without FF, for 10 patients with brain metastasis from NSCLC. The evaluation of the treatment plans included homogeneity index (HI), conformity index (CI), monitor units (MU), mean dose (Dmean), treatment time, and the influence of FFF on volumes. There was no difference in CI or HI between FFF and FF models with 3D-CRT, IMRT, and VMAT plans. At 6 MV, a lower Dmean was seen in the FFF model of 3D-CRT and in the VMAT plan at 10 MV. In the IMRT 6 MV, IMRT 10 MV, and VMAT 10 MV plans, higher MUs were seen in the FFF models. FFF treatments are similar in quality to FF plans, generally lead to more monitor units, and are associated with shorter treatment times. FFF plans ranked by the order of superiority in terms of a time advantage are VMAT, 3D-CRT, and IMRT.

  7. The Effect of Flattening Filter Free on Three-dimensional Conformal Radiation Therapy (3D-CRT), Intensity-Modulated Radiation Therapy (IMRT), and Volumetric Modulated Arc Therapy (VMAT) Plans for Metastatic Brain Tumors from Non-small Cell Lung Cancer.

    PubMed

    Shi, Li-Wan; Lai, You-Qun; Lin, Qin; Ha, Hui-Ming; Fu, Li-Rong

    2015-07-01

    Flattening filter free (FFF) may affect outcome measures of radiotherapy. The objective of this study is to compare the dosimetric parameters in three types of radiotherapy plans, three-dimensional conformal radiation therapy (3D-CRT), intensity-modulated radiation therapy (IMRT), and volumetric modulated arc therapy (VMAT), with or without the flattening filter (FF), developed for the treatment of metastatic brain tumors from non-small cell lung cancer (NSCLC). From July 2013 to October 2013, 3D-CRT, IMRT, and VMAT treatment plans were designed using 6 MV and 10 MV, with and without FF, for 10 patients with brain metastasis from NSCLC. The evaluation of the treatment plans included homogeneity index (HI), conformity index (CI), monitor units (MU), mean dose (Dmean), treatment time, and the influence of FFF on volumes. There was no difference in CI or HI between FFF and FF models with 3D-CRT, IMRT, and VMAT plans. At 6 MV, a lower Dmean was seen in the FFF model of 3D-CRT and in the VMAT plan at 10 MV. In the IMRT 6 MV, IMRT 10 MV, and VMAT 10 MV plans, higher MUs were seen in the FFF models. FFF treatments are similar in quality to FF plans, generally lead to more monitor units, and are associated with shorter treatment times. FFF plans ranked by the order of superiority in terms of a time advantage are VMAT, 3D-CRT, and IMRT. PMID:26011493

  8. A Phase II Study of Synchronous Three-Dimensional Conformal Boost to the Gross Tumor Volume for Patients With Unresectable Stage III Non-Small-Cell Lung Cancer: Results of Korean Radiation Oncology Group 0301 Study

    SciTech Connect

    Cho, Kwan Ho Ahn, Sung Ja; Pyo, Hong Ryull; Kim, Kyu-Sik; Kim, Young-Chul; Moon, Sung Ho; Han, Ji-Youn; Kim, Heung Tae; Koom, Woong Sub; Lee, Jin Soo

    2009-08-01

    Purpose: We evaluated the efficacy of synchronous three-dimensional (3D) conformal boost to the gross tumor volume (GTV) in concurrent chemoradiotherapy for patients with locally advanced non-small-cell lung cancer (NSCLC). Methods and Materials: Eligibility included unresectable Stage III NSCLC with no pleural effusion, no supraclavicular nodal metastases, and Eastern Cooperative Oncology Group performance score of 0-1. Forty-nine patients with pathologically proven NSCLC were enrolled. Eighteen patients had Stage IIIA and 31 had Stage IIIB. By using 3D conformal radiotherapy (RT) techniques, a dose of 1.8 Gy was delivered to the planning target volume with a synchronous boost of 0.6 Gy to the GTV, with a total dose of 60 Gy to the GTV and 45 Gy to the planning target volume in 25 fractions during 5 weeks. All patients received weekly chemotherapy consisting of paclitaxel and carboplatin during RT. Results: With a median follow-up of 36.8 months (range, 29.0-45.5 months) for surviving patients, median survival was 28.1 months. One-, 2- and 3-year overall survival rates were 77%, 56.4%, and 43.8%, respectively. Corresponding local progression-free survival rates were 71.2%, 53.7%, and 53.7%. Compliance was 90% for RT and 88% for chemotherapy. Acute esophagitis of Grade 2 or higher occurred in 29 patients. Two patients with T4 lesions died of massive bleeding and hemoptysis during treatment (Grade 5). Overall late toxicity was acceptable. Conclusions: Based on the favorable outcome with acceptable toxicity, the acceleration scheme using 3D conformal GTV boost in this trial is warranted to compare with conventional fractionation in a Phase III trial.

  9. Three-dimensional light trap for reflective particles

    DOEpatents

    Neal, D.R.

    1999-08-17

    A system is disclosed for containing either a reflective particle or a particle having an index of refraction lower than that of the surrounding media in a three-dimensional light cage. A light beam from a single source illuminates an optics system and generates a set of at least three discrete focused beams that emanate from a single exit aperture and focus on to a focal plane located close to the particle. The set of focal spots defines a ring that surrounds the particle. The set of focused beams creates a ``light cage`` and circumscribes a zone of no light within which the particle lies. The surrounding beams apply constraining forces (created by radiation pressure) to the particle, thereby containing it in a three-dimensional force field trap. A diffractive element, such as an aperture multiplexed lens, or either a Dammann grating or phase element in combination with a focusing lens, may be used to generate the beams. A zoom lens may be used to adjust the size of the light cage, permitting particles of various sizes to be captured and contained. 10 figs.

  10. Three-dimensional light trap for reflective particles

    DOEpatents

    Neal, Daniel R.

    1999-01-01

    A system for containing either a reflective particle or a particle having an index of refraction lower than that of the surrounding media in a three-dimensional light cage. A light beam from a single source illuminates an optics system and generates a set of at least three discrete focussed beams that emanate from a single exit aperture and focus on to a focal plane located close to the particle. The set of focal spots defines a ring that surrounds the particle. The set of focussed beams creates a "light cage" and circumscribes a zone of no light within which the particle lies. The surrounding beams apply constraining forces (created by radiation pressure) to the particle, thereby containing it in a three-dimensional force field trap. A diffractive element, such as an aperture multiplexed lens, or either a Dammann grating or phase element in combination with a focusing lens, may be used to generate the beams. A zoom lens may be used to adjust the size of the light cage, permitting particles of various sizes to be captured and contained.

  11. Primary and Secondary Three Dimensional Microbatteries

    NASA Astrophysics Data System (ADS)

    Cirigliano, Nicolas

    Today's MEMS devices are limited more so by the batteries that supply their power than the fabrication methods used to build them. Thick battery electrodes are capable of providing adequate energy, but long and tortuous diffusion pathways lead to low power capabilities. On the other hand, thin film batteries can operate at significant current densities but require large surface areas to supply practical energy. This dilemma can be solved by either developing new high capacity materials or by engineering new battery designs that decouple power and energy. Three dimensional batteries redesign traditional configurations to create nonplanar interfaces between battery components. This can be done by introducing hierarchical structures into the electrode shape. Designs such as these provide a maximum surface area over which chemical reactions can occur. Furthermore, by maintaining small feature sizes, ion diffusion and electronic transport distances can remain minimal. Manipulating these properties ensures fast kinetics that are required for high power situations. Energy density is maximized by layering material in the vertical direction, thus ensuring a minimal footprint area. Three dimensional carbon electrodes are fabricated using basic MEMS techniques. A silicon mold is anisotropically etched to produce channels of a predetermined diameter. The channels are then filled using an infiltration technique with electrode slurry. Once dried, the mold is attached to a current collector and etched using a XeF2 process. Electrodes of varying feature sizes have been fabricated using this method with aspect ratios ranging from 3.5:1 to 7:1. 3D carbon electrodes are shown to obtain capacities over 8 mAh/cm2 at 0.1 mA/cm2, or nearly 700% higher than planar carbon electrodes. When assembled with a planar cathode, the battery cell produced an average discharge capacity of 40 J/cm 2 at a current density of 0.2 mA/cm2. This places the energy density values slightly less than thick

  12. Flow Fields Over Unsteady Three Dimensional Dunes

    NASA Astrophysics Data System (ADS)

    Hardy, R. J.; Reesink, A.; Parsons, D. R.; Ashworth, P. J.; Best, J.

    2013-12-01

    The flow field over dunes has been extensively measured in laboratory conditions and there is general understanding on the nature of the flow over dunes formed under equilibrium flow conditions. However, fluvial systems typically experience unsteady flow and therefore the sediment-water interface is constantly responding and reorganizing to these unsteady flows, over a range of both spatial and temporal scales. This is primarily through adjustment of bed forms (including ripples, dunes and bar forms) which then subsequently alter the flow field. This paper investigates, through the application of a numerical model, the influence of these roughness elements on the overall flow and the increase in flow resistance. A series of experiments were undertaken in a flume, 16m long and 2m wide, where a fine sand (D50 of 239μm) mobile bed was water worked under a range of unsteady hydraulic conditions to generate a series of quasi-equilibrium three dimensional bed forms. During the experiments flow was measured with acoustic Doppler velocimeters, (aDv's). On four occasions the flume was drained and the bed topography measured with terrestrial LiDAR to create digital elevation models. This data provide the necessary boundary conditions and validation data for a Large Eddy Simulation (LES) model, which provided a three dimensional time dependent prediction of flow over the four static beds. The numerical predicted flow is analyzed through a series of approaches, and included: i) standard Reynolds decomposition to the flow fields; ii) Eulerian coherent structure detection methods based on the invariants of the velocity gradient tensor; iii) Lagrangian coherent structure identification methods based upon direct Lyapunov exponents (DLE). The results show that superimposed bed forms can cause changes in the nature of the classical separated flow region in particularly the number of locations where vortices are shed and the point of flow reattachment, which may be important for

  13. Three-dimensional Printing in the Intestine.

    PubMed

    Wengerter, Brian C; Emre, Gulus; Park, Jea Young; Geibel, John

    2016-08-01

    Intestinal transplantation remains a life-saving option for patients with severe intestinal failure. With the advent of advanced tissue engineering techniques, great strides have been made toward manufacturing replacement tissues and organs, including the intestine, which aim to avoid transplant-related complications. The current paradigm is to seed a biocompatible support material (scaffold) with a desired cell population to generate viable replacement tissue. Although this technique has now been extended by the three-dimensional (3D) printing of geometrically complex scaffolds, the overall approach is hindered by relatively slow turnover and negative effects of residual scaffold material, which affects final clinical outcome. Methods recently developed for scaffold-free 3D bioprinting may overcome such obstacles and should allow for rapid manufacture and deployment of "bioprinted organs." Much work remains before 3D bioprinted tissues can enter clinical use. In this brief review we examine the present state and future perspectives of this nascent technology before full clinical implementation. PMID:27189913

  14. Three dimensional simulations of internal solitary waves

    NASA Astrophysics Data System (ADS)

    Li, Guotu; Rizzi, Francesco; Knio, Omar

    2014-11-01

    This study focuses on mass transport and mixing induced by mode-2 internal solitary waves (ISWs) propagating along a pycnocline between two continuously stratified fluid layers. A direct numerical simulation (DNS) model is developed for the incompressible three-dimensional Navier-Stokes equations in the Boussinesq limit. By using high order schemes in both space and time, the model is able to accurately capture the convection-dominated flow at high Reynolds and Schmidt numbers. Simulations both with and without background shear are conducted. The spatial frequency analysis of both density and vorticity fields reveals that no long range spanwise structures are present during the propagation of ISWs, which makes a relatively short spanwise depth sufficient to characterize the evolution of the flow. The growth of 3D structures during the propagation of ISWs is quantified using a spanwise roughness measure. The flow energy budget, dye transport, density mixing and vortex circulations are also analyzed. Work supported by the Office of Naval Research, Physical Oceanography Program.

  15. Three dimensional characterization and archiving system

    SciTech Connect

    Sebastian, R.L.; Clark, R.; Gallman, P.

    1995-10-01

    The Three Dimensional Characterization and Archiving System (3D-ICAS) is being developed as a remote system to perform rapid in situ analysis of hazardous organics and radionuclide contamination on structural materials. Coleman Research and its subcontractors, Thermedics Detection, Inc. (TD) and the University of Idaho (UI) are in the second phase of a three phase program to develop 3D-ICAS to support Decontamination and Decommissioning (D&D) operations. Accurate physical characterization of surfaces and the radioactive and organic is a critical D&D task. Surface characterization includes identification of potentially dangerous inorganic materials, such as asbestos and transite. The 3D-ICAS system robotically conveys a multisensor probe near the surface to be inspected. The sensor position and orientation are monitored and controlled by Coherent laser radar (CLR) tracking. The ICAS fills the need for high speed automated organic analysis by means of gas chromatography-mass spectrometry sensors, and also by radionuclide sensors which combines alpha, beta, and gamma counting.

  16. Three-dimensional landing zone ladar

    NASA Astrophysics Data System (ADS)

    Savage, James; Goodrich, Shawn; Burns, H. N.

    2016-05-01

    Three-Dimensional Landing Zone (3D-LZ) refers to a series of Air Force Research Laboratory (AFRL) programs to develop high-resolution, imaging ladar to address helicopter approach and landing in degraded visual environments with emphasis on brownout; cable warning and obstacle avoidance; and controlled flight into terrain. Initial efforts adapted ladar systems built for munition seekers, and success led to a the 3D-LZ Joint Capability Technology Demonstration (JCTD) , a 27-month program to develop and demonstrate a ladar subsystem that could be housed with the AN/AAQ-29 FLIR turret flown on US Air Force Combat Search and Rescue (CSAR) HH-60G Pave Hawk helicopters. Following the JCTD flight demonstration, further development focused on reducing size, weight, and power while continuing to refine the real-time geo-referencing, dust rejection, obstacle and cable avoidance, and Helicopter Terrain Awareness and Warning (HTAWS) capability demonstrated under the JCTD. This paper summarizes significant ladar technology development milestones to date, individual LADAR technologies within 3D-LZ, and results of the flight testing.

  17. Three-dimensional charge coupled device

    DOEpatents

    Conder, Alan D.; Young, Bruce K. F.

    1999-01-01

    A monolithic three dimensional charged coupled device (3D-CCD) which utilizes the entire bulk of the semiconductor for charge generation, storage, and transfer. The 3D-CCD provides a vast improvement of current CCD architectures that use only the surface of the semiconductor substrate. The 3D-CCD is capable of developing a strong E-field throughout the depth of the semiconductor by using deep (buried) parallel (bulk) electrodes in the substrate material. Using backside illumination, the 3D-CCD architecture enables a single device to image photon energies from the visible, to the ultra-violet and soft x-ray, and out to higher energy x-rays of 30 keV and beyond. The buried or bulk electrodes are electrically connected to the surface electrodes, and an E-field parallel to the surface is established with the pixel in which the bulk electrodes are located. This E-field attracts charge to the bulk electrodes independent of depth and confines it within the pixel in which it is generated. Charge diffusion is greatly reduced because the E-field is strong due to the proximity of the bulk electrodes.

  18. Three-dimensional modeling of tsunami waves

    SciTech Connect

    Mader, C.L.

    1985-01-01

    Two- and three-dimensional, time-dependent, nonlinear, incompressible, viscous flow calculations of realistic models of tsunami wave formation and run up have been performed using the Los Alamos-developed SOLA-3D code. The results of the SOLA calculations are compared with shallow-water, long-wave calculations for the same problems using the SWAN code. Tsunami wave formation by a continental slope subsidence has been examined using the two numerical models. The SOLA waves were slower than the SWAN waves and the interaction with the shoreline was more complicated for the SOLA waves. In the SOLA calculation, the first wave was generated by the cavity being filled along the shoreline close to the source of motion. The second wave was generated by the cavity being filled from the deep water end. The two waves interacted along the shoreline resulting in the second wave being the largest wave with a velocity greater than the first wave. The second wave overtook the first wave at later times and greater distances from the source. In the SWAN calculation, the second wave was smaller than the first wave. 6 refs.

  19. Three-dimensional supersonic internal flows

    NASA Astrophysics Data System (ADS)

    Mohan, J. A.; Skews, B. W.

    2013-09-01

    In order to examine the transition between regular and Mach reflection in a three-dimensional flow, a range of special geometry test pieces, and inlets, were designed. The concept is to have a geometry consisting of two plane wedges which results in regular reflection between the incident waves off the top and bottom of the inlet capped by two curved end sections causing Mach reflection. The merging of these two reflection patterns and the resulting downstream flow are studied using laser vapor screen and shadowgraph imaging supported by numerical simulation. An angled Mach disc is formed which merges with the line of regular reflection. A complex wave pattern results with the generation of a bridging shock connecting the reflected wave from the Mach reflection with the reflected waves from the regular reflection. In order to experimentally access the flow within the duct, a number of tests were conducted with one end cap removed. This resulted in a modified flow due to the expansive flow at the open end the influence of which was also studied in more detail.

  20. Collimation and Stability of Three Dimensional Jets

    NASA Astrophysics Data System (ADS)

    Hardee, P. E.; Clarke, D. A.; Howell, D. A.

    1993-12-01

    Three-dimensional numerical simulations of cylindrical jets established in equilibrium with a surrounding uniform medium have been performed. Large scale structures such as helical twisting of the jet, elliptical distortion and bifurcation of the jet, and triangular distortion and trifurcation of the jet have been seen in the simulations. The grid resolution has been sufficient to allow the development of structures on smaller scales and has revealed higher order distortions of the jet surface and complex structure internal to the jet. However, smaller scale surface distortion and internal jet structure do not significantly modify the large scale dynamics. It is the large scale surface distortions and accompanying filamentation that dominate the jet dynamics. Decollimation occurs as the jet bifurcates or trifurcates. Jets with density less than the immediately surrounding medium rapidly decollimate and expand as the jet filaments into multiple streams leading to shock heating and mass entrainment. The resulting morphology resembles a turbulent plume and might be relevant to some FRI type radio sources. Jet densities higher than the immediately surrounding medium are required to produce FRII type radio source jet morphology and protostellar jet morphology. Thus, while jets may be denser or lighter than the external medium through which they propagate, it is the conditions in the cocoon or lobe around the jet that governs the dynamics far behind the jet front. This work was supported by NSF grant AST-8919180, EPSCoR grant EHR-9108761 and NSF-REU grant AST-9300413.

  1. Three-dimensional subband coding of video.

    PubMed

    Podilchuk, C I; Jayant, N S; Farvardin, N

    1995-01-01

    We describe and show the results of video coding based on a three-dimensional (3-D) spatio-temporal subband decomposition. The results include a 1-Mbps coder based on a new adaptive differential pulse code modulation scheme (ADPCM) and adaptive bit allocation. This rate is useful for video storage on CD-ROM. Coding results are also shown for a 384-kbps rate that are based on ADPCM for the lowest frequency band and a new form of vector quantization (geometric vector quantization (GVQ)) for the data in the higher frequency bands. GVQ takes advantage of the inherent structure and sparseness of the data in the higher bands. Results are also shown for a 128-kbps coder that is based on an unbalanced tree-structured vector quantizer (UTSVQ) for the lowest frequency band and GVQ for the higher frequency bands. The results are competitive with traditional video coding techniques and provide the motivation for investigating the 3-D subband framework for different coding schemes and various applications. PMID:18289965

  2. Survey Of Three-Dimensional Television

    NASA Astrophysics Data System (ADS)

    Butterfield, James F.

    1980-06-01

    Since the introduction of television, various types of three-dimensional video systems have been used for industrial, medical, educational and entertainment purposes. The systems can be divided into two classes: (1) Stereoscopic Video Systems, which require special glasses or viewing aids; (2) Autostereoscopic Video Systems, which do not require glasses and are viewed by free vision. The two or more images required for these displays are picked-up by stereo optics with a single camera and multiplexed on a single communi-cation channel or they are picked up by two or more cameras utilizing an individual channel for each camera. One or more CRT's with stereo optics are employed in the receiver. The stereoscopic display provides the viewer with added realism and spacial information not available in any other manner. For entertainment purposes, the 3D picture enhances almost any program, including sports, drama and news. Typical industrial applications are for: remote viewing in connection with the remote driving of vehicles or operating manipulators; educational studies of solid geometry and atomic structure; and medical studies of surgical procedures. Stereo video also is being used in connection with microscopic optics to provide a stereo video microscope which has numerous advantages over a conventional optical microscope.

  3. Three dimensional characterization and archiving system

    SciTech Connect

    Sebastian, R.L.; Clark, R.; Gallman, P.

    1995-12-01

    The Three Dimensional Characterization and Archiving System (3D-ICAS) is being developed as a remote system to perform rapid in situ analysis of hazardous organics and radionuclide contamination on structural materials. Coleman Research and its subcontractors, Thermedics Detection, Inc. (TD) and the University of Idaho (UI) are in the second phase of a three phase program to develop 3D-ICAS to support Decontamination and Decommissioning (D&D) operations. Accurate physical characterization of surfaces and the radioactive and organic is a critical D&D task. Surface characterization includes identification of potentially dangerous inorganic materials, such as asbestos and transite. Real-time remotely operable characterization instrumentation will significantly advance the analysis capabilities beyond those currently employed. Chemical analysis is a primary area where the characterization process will be improved. Chemical analysis plays a vital role throughout the process of decontamination. Before clean-up operations can begin the site must be characterized with respect to the type and concentration of contaminants, and detailed site mapping must clarify areas of both high and low risk. During remediation activities chemical analysis provides a means to measure progress and to adjust clean-up strategy. Once the clean-up process has been completed the results of chemical analysis will verify that the site is in compliance with federal and local regulations.

  4. Three-dimensional null point reconnection regimes

    SciTech Connect

    Priest, E. R.; Pontin, D. I.

    2009-12-15

    Recent advances in theory and computational experiments have shown the need to refine the previous categorization of magnetic reconnection at three-dimensional null points--points at which the magnetic field vanishes. We propose here a division into three different types, depending on the nature of the flow near the spine and fan of the null. The spine is an isolated field line which approaches the null (or recedes from it), while the fan is a surface of field lines which recede from it (or approach it). So-called torsional spine reconnection occurs when field lines in the vicinity of the fan rotate, with current becoming concentrated along the spine so that nearby field lines undergo rotational slippage. In torsional fan reconnection field lines near the spine rotate and create a current that is concentrated in the fan with a rotational flux mismatch and rotational slippage. In both of these regimes, the spine and fan are perpendicular and there is no flux transfer across spine or fan. The third regime, called spine-fan reconnection, is the most common in practice and combines elements of the previous spine and fan models. In this case, in response to a generic shearing motion, the null point collapses to form a current sheet that is focused at the null itself, in a sheet that locally spans both the spine and fan. In this regime the spine and fan are no longer perpendicular and there is flux transfer across both of them.

  5. Three-Dimensional Optical Coherence Tomography

    NASA Technical Reports Server (NTRS)

    Gutin, Mikhail; Wang, Xu-Ming; Gutin, Olga

    2009-01-01

    Three-dimensional (3D) optical coherence tomography (OCT) is an advanced method of noninvasive infrared imaging of tissues in depth. Heretofore, commercial OCT systems for 3D imaging have been designed principally for external ophthalmological examination. As explained below, such systems have been based on a one-dimensional OCT principle, and in the operation of such a system, 3D imaging is accomplished partly by means of a combination of electronic scanning along the optical (Z) axis and mechanical scanning along the two axes (X and Y) orthogonal to the optical axis. In 3D OCT, 3D imaging involves a form of electronic scanning (without mechanical scanning) along all three axes. Consequently, the need for mechanical adjustment is minimal and the mechanism used to position the OCT probe can be correspondingly more compact. A 3D OCT system also includes a probe of improved design and utilizes advanced signal- processing techniques. Improvements in performance over prior OCT systems include finer resolution, greater speed, and greater depth of field.

  6. Three dimensional characterization and archiving system

    SciTech Connect

    Sebastian, R.L.; Clark, R.; Gallman, P.

    1996-04-01

    The Three Dimensional Characterization and Archiving System (3D-ICAS) is being developed as a remote system to perform rapid in situ analysis of hazardous organics and radionuclide contamination on structural materials. Coleman Research and its subcontractors, Thermedics Detection, Inc. (TD) and the University of Idaho (UI) are in the second phase of a three phase program to develop 3D-ICAS to support Decontamination and Decommissioning (D and D) operations. Accurate physical characterization of surfaces and the radioactive and organic is a critical D and D task. Surface characterization includes identification of potentially dangerous inorganic materials, such as asbestos and transite. Real-time remotely operable characterization instrumentation will significantly advance the analysis capabilities beyond those currently employed. Chemical analysis is a primary area where the characterization process will be improved. The 3D-ICAS system robotically conveys a multisensor probe near the surfaces to be inspected. The sensor position and orientation are monitored and controlled using coherent laser radar (CLR) tracking. The CLR also provides 3D facility maps which establish a 3D world view within which the robotic sensor system can operate.

  7. Lattice theory of three-dimensional cracks

    NASA Technical Reports Server (NTRS)

    Esterling, D. M.

    1976-01-01

    The problem of the stability of a three-dimensional crack is analyzed within a lattice-statics approximation. The consequence of introducing a jog into the crack face as well as the effects of various nonlinear-force laws are studied. The phenomenon of lattice trapping (upper and lower bounds on the applied stress for an equilibrium crack of given length) is again obtained. It is possible to obtain some physical insight into which aspects of the force law are critical for crack stability. In particular, the inadequacy of a thermodynamic approach - which relates the critical stress to a surface energy corresponding to the area under the cohesive-force-vs-displacement curve - is demonstrated. Surface energy is a global property of the cohesive-force law. Crack stability is sensitive to much more refined aspects of the cohesive-force law. Crack healing is sensitive to the long-range portion of the cohesive force. Crack expansion is sensitive to the position of the maximum in the cohesive-force relation.

  8. Surface fitting three-dimensional bodies

    NASA Technical Reports Server (NTRS)

    Dejarnette, F. R.

    1974-01-01

    The geometry of general three-dimensional bodies is generated from coordinates of points in several cross sections. Since these points may not be smooth, they are divided into segments and general conic sections are curve fit in a least-squares sense to each segment of a cross section. The conic sections are then blended in the longitudinal direction by fitting parametric cubic-spline curves through coordinate points which define the conic sections in the cross-sectional planes. Both the cross-sectional and longitudinal curves may be modified by specifying particular segments as straight lines and slopes at selected points. Slopes may be continuous or discontinuous and finite or infinite. After a satisfactory surface fit has been obtained, cards may be punched with the data necessary to form a geometry subroutine package for use in other computer programs. At any position on the body, coordinates, slopes and second partial derivatives are calculated. The method is applied to a blunted 70 deg delta wing, and it was found to generate the geometry very well.

  9. Magnetophotonic response of three-dimensional opals.

    PubMed

    Caicedo, José Manuel; Pascu, Oana; López-García, Martín; Canalejas, Víctor; Blanco, Alvaro; López, Cefe; Fontcuberta, Josep; Roig, Anna; Herranz, Gervasi

    2011-04-26

    Three-dimensional magnetophotonic crystals (3D-MPCs) are being postulated as appropriate platforms to tailor the magneto-optical spectral response of magnetic materials and to incorporate this functionality in a new generation of optical devices. By infiltrating self-assembled inverse opal structures with monodisperse nickel nanoparticles we have fabricated 3D-MPCs that show a sizable enhancement of the magneto-optical signal at frequencies around the stop-band edges of the photonic crystals. We have established a proper methodology to disentangle the intrinsic magneto-optical spectra from the nonmagnetic optical activity of the 3D-MPCs. The results of the optical and magneto-optical characterization are consistent with a homogeneous magnetic infiltration of the opal structure that gives rise to both a red-shift of the optical bandgap and a modification of the magneto-optical spectral response due to photonic bandgap effects. The results of our investigation demonstrate the potential of 3D-MPCs fabricated following the approach outlined here and offer opportunities to adapt the magneto-optical spectral response at optical frequencies by appropriate design of the opal structure or magnetic field strength.

  10. Two and three dimensional magnetotelluric inversion

    NASA Astrophysics Data System (ADS)

    Booker, J. R.

    Improved imaging of underground electrical structure has wide practical importance in exploring for groundwater, mineral, and geothermal resources, and in characterizing oil fields and waste sites. Because the electromagnetic inverse problem for natural sources is generally multidimensional, most imaging algorithms saturate available computer power long before they can deal with complete data sets. We have developed an algorithm to directly invert large multidimensional magnetotelluric data sets that is orders of magnitude faster than competing methods. In the past year, we have extended the two-dimensional (2D) version to permit incorporation of geological constraints, have developed ways to assess model resolution, and have completed work on an accurate and fast three-dimensional (3D) forward algorithm. We are proposing to further enhance the capabilities of the 2D code and to incorporate the 3D forward code in a fully 3D inverse algorithm. Finally, we will embark on an investigation of related EM imaging techniques which may have the potential for further increasing resolution.

  11. Two and three dimensional magnetotelluric inversion

    SciTech Connect

    Booker, J.R.

    1994-07-01

    Improved imaging of underground electrical structure has wide practical importance in exploring for groundwater, mineral and geothermal resources, and in characterizing oil fields and waste sites. Because the electromagnetic inverse problem for natural sources is generally multi-dimensional, most imaging algorithms saturate available computer power long before they can deal with complete data sets. We have developed an algorithm to directly invert large multi-dimensional magnetotelluric data sets that is orders of magnitude faster than competing methods. In the past year, we have extended the two- dimensional (2D) version to permit incorporation of geological constraints, have developed ways to assess model resolution and have completed work on an accurate and fast three-dimensional (3D) forward algorithm. We are proposing to further enhance the capabilities of the 2D code and to incorporate the 3D forward code in a fully 3D inverse algorithm. Finally, we will embark on an investigation of related EM imaging techniques which may have the potential for further increasing resolution.

  12. Two and three dimensional magnetotelluric inversion

    SciTech Connect

    Booker, J.

    1993-01-01

    Electrical conductivity depends on properties such as the presence of ionic fluids in interconnected pores that are difficult to sense with other remote sensing techniques. Thus improved imaging of underground electrical structure has wide practical importance in exploring for groundwater, mineral and geothermal resources, and in assessing the diffusion of fluids in oil fields and waste sites. Because the electromagnetic inverse problem is fundamentally multi-dimensional, most imaging algorithms saturate available computer power long before they can deal with the complete data set. We have developed an algorithm to directly invert large multi-dimensional data sets that is orders of magnitude faster than competing methods. We have proven that a two-dimensional (2D) version of the algorithm is highly effective for real data and have made substantial progress towards a three-dimensional (3D) version. We are proposing to cure identified shortcomings and substantially expand the utility of the existing 2D program, overcome identified difficulties with extending our method to three-dimensions (3D) and embark on an investigation of related EM imaging techniques which may have the potential for even further increasing resolution.

  13. A three-dimensional human walking model

    NASA Astrophysics Data System (ADS)

    Yang, Q. S.; Qin, J. W.; Law, S. S.

    2015-11-01

    A three-dimensional human bipedal walking model with compliant legs is presented in this paper. The legs are modeled with time-variant dampers, and the model is able to characterize the gait pattern of an individual using a minimal set of parameters. Feedback control, for both the forward and lateral movements, is implemented to regulate the walking performance of the pedestrian. The model provides an improvement over classic invert pendulum models. Numerical studies were undertaken to investigate the effects of leg stiffness and attack angle. Simulation results show that when walking at a given speed, increasing the leg stiffness with a constant attack angle results in a longer step length, a higher step frequency, a faster walking speed and an increase in both the peak vertical and lateral ground reaction forces. Increasing the attack angle with a constant leg stiffness results in a higher step frequency, a decrease in the step length, an increase in the total energy of the system and a decrease in both the peak vertical and lateral ground reaction forces.

  14. Quantitative representation of three-dimensional cell culturemodels

    SciTech Connect

    Chang, Hang; Park, Catherine; Parvin, Bahram

    2007-02-01

    Three-dimensional mammary cell culture models offer new opportunities for the development of computational techniques for segmentation, localization, and multicellular organization. Under normal conditions, these assays form a symmetrical, hollow structure, which is necessary for their functional operation. Often, the nuclear compartments are labeled, which provides context for quantitative protein localization or colony structure through fluorescent microscopy. These colonies are first delineated from the background using the level set method. Within each colony, nuclear regions are then bounded by their center of mass through iterative radial voting, and a local neighborhood for each nucleus is established through Voronoi tessellation. Finally, the level set method is applied again within each Voronoi region to delineate the nuclear compartment. The paper concludes with the application of the proposed method to a set of experimental data demonstrating a stable solution when iterative radial voting and level set methods are used synergistically. Furthermore, segmented colonies are characterized for architectural changes as a result of ionizing radiation.

  15. High-Dose Hypofractionated Proton Beam Radiation Therapy Is Safe and Effective for Central and Peripheral Early-Stage Non-Small Cell Lung Cancer: Results of a 12-Year Experience at Loma Linda University Medical Center

    SciTech Connect

    Bush, David A.; Cheek, Gregory; Zaheer, Salman; Wallen, Jason; Mirshahidi, Hamid; Katerelos, Ari; Grove, Roger; Slater, Jerry D.

    2013-08-01

    Purpose: We update our previous reports on the use of hypofractionated proton beam radiation therapy for early-stage lung cancer patients. Methods and Materials: Eligible subjects had biopsy-proven non-small cell carcinoma of the lung and were medically inoperable or refused surgery. Clinical workup required staging of T1 or T2, N0, M0. Subjects received hypofractionated proton beam therapy to the primary tumor only. The dose delivered was sequentially escalated from 51 to 60 Gy, then to 70 Gy in 10 fractions over 2 weeks. Endpoints included toxicity, pulmonary function, overall survival (OS), disease-specific survival (DSS), and local control (LC). Results: One hundred eleven subjects were analyzed for treatment outcomes. The patient population had the following average characteristics; age 73.2 years, tumor size 3.6 cm, and 1.33 L forced expiratory volume in 1 second. The entire group showed improved OS with increasing dose level (51, 60, and 70 Gy) with a 4-year OS of 18%, 32%, and 51%, respectively (P=.006). Peripheral T1 tumors exhibited LC of 96%, DSS of 88%, and OS of 60% at 4 years. Patients with T2 tumors showed a trend toward improved LC and survival with the 70-Gy dose level. On multivariate analysis, larger tumor size was strongly associated with increased local recurrence and decreased survival. Central versus peripheral location did not correlate with any outcome measures. Clinical radiation pneumonitis was not found to be a significant complication, and no patient required steroid therapy after treatment for radiation pneumonitis. Pulmonary function was well maintained 1 year after treatment. Conclusions: High-dose hypofractionated proton therapy achieves excellent outcomes for lung carcinomas that are peripherally or centrally located. The 70-Gy regimen has been adopted as standard therapy for T1 tumors at our institution. Larger T2 tumors show a trend toward improved outcomes with higher doses, suggesting that better results could be seen with

  16. Isotropic three-dimensional MRI-Fricke-infused gel dosimetry

    SciTech Connect

    Cho, Nai-Yu; Chu, Woei-Chyn; Huang, Sung-Cheng; Chung, Wen-Yuh; Guo, Wan-Yuo

    2013-05-15

    Purpose: Fricke-infused gel has been shown to be a simple and attainable method for the conformal measurement of absorbed radiation dose. Nevertheless, its accuracy is seriously hindered by the irreversible ferric ion diffusion during magnetic resonance imaging, particularly when three-dimensional (3D) dose measurement in radiosurgery is considered. In this study, the authors developed a fast three-dimensional spin-echo based Fricke gel dosimetry technique to reduce the adverse effects of ferric ion diffusion and to obtain an accurate isotropic 3D dose measurement. Methods: A skull shaped phantom containing Fricke-infused gel was irradiated using Leksell Gamma Knife. The rapid image-based dosimetry technique was applied with the use of a 3D fast spin-echo magnetic resonance imaging sequence. The authors mathematically derived and experimentally validated the correlations between dose-response characteristics and parameters of the 3D fast spin-echo MR imaging sequence. Absorbed dose profiles were assessed and compared to the calculated profiles given by the Gamma Knife treatment planning system. Coefficient of variance (CV%) and coefficient of determination (R{sup 2}) were used to evaluate the precision of dose-response curve estimation. The agreement between the measured and the planned 3D dose distributions was quantified by gamma-index analysis of two acceptance criteria. Results: Proper magnetic resonance imaging parameters were explored to render an accurate three-dimensional absorbed dose mapping with a 1 mm{sup 3} isotropic image resolution. The efficacy of the dose-response estimation was approved by an R{sup 2} > 0.99 and an average CV% of 1.6%. Average gamma pass-rate between the experimentally measured and GammaPlan calculated dose distributions were 83.8% and 99.7% for 2%/2 and 3%/3 mm criteria, respectively. Conclusions: With the designed MR imaging sequence and parameters, total 3D MR acquisition time was confined to within 20 min postirradiation

  17. Radial Stellar Pulsation and Three-dimensional Convection. IV. Full Amplitude Three-dimensional Solutions

    NASA Astrophysics Data System (ADS)

    Geroux, Christopher M.; Deupree, Robert G.

    2015-02-01

    Three-dimensional hydrodynamic simulations of full amplitude RR Lyrae stars have been computed for several models across the instability strip. The three-dimensional nature of the calculations allows convection to be treated without reference to a phenomenological approach such as the local mixing length theory. Specifically, the time-dependent interaction of large-scale eddies and radial pulsation is controlled by conservation laws, while the effects of smaller convective eddies are simulated by an eddy viscosity model. The light amplitudes for these calculations are quite similar to those of our previous two-dimensional calculations in the middle of the instability strip, but somewhat lower near the red edge, the fundamental blue edge, and for the one first overtone model we computed. The time-dependent interaction between the radial pulsation and the convective energy transport is essentially the same in three dimensions as it is in two dimensions. There are some differences between the light curves of the two- and three-dimensional simulations, particularly during decreasing light. Reasons for the differences, both numerical and physical, are explored.

  18. RADIAL STELLAR PULSATION AND THREE-DIMENSIONAL CONVECTION. IV. FULL AMPLITUDE THREE-DIMENSIONAL SOLUTIONS

    SciTech Connect

    Geroux, Christopher M.; Deupree, Robert G.

    2015-02-10

    Three-dimensional hydrodynamic simulations of full amplitude RR Lyrae stars have been computed for several models across the instability strip. The three-dimensional nature of the calculations allows convection to be treated without reference to a phenomenological approach such as the local mixing length theory. Specifically, the time-dependent interaction of large-scale eddies and radial pulsation is controlled by conservation laws, while the effects of smaller convective eddies are simulated by an eddy viscosity model. The light amplitudes for these calculations are quite similar to those of our previous two-dimensional calculations in the middle of the instability strip, but somewhat lower near the red edge, the fundamental blue edge, and for the one first overtone model we computed. The time-dependent interaction between the radial pulsation and the convective energy transport is essentially the same in three dimensions as it is in two dimensions. There are some differences between the light curves of the two- and three-dimensional simulations, particularly during decreasing light. Reasons for the differences, both numerical and physical, are explored.

  19. Three-dimensional structure of Theiler virus.

    PubMed Central

    Grant, R A; Filman, D J; Fujinami, R S; Icenogle, J P; Hogle, J M

    1992-01-01

    Theiler murine encephalomyelitis virus strains are categorized into two groups, a neurovirulent group that rapidly kills the host, and a demyelinating group that causes a generally nonlethal infection of motor neurons followed by a persistent infection of the white matter with demyelinating lesions similar to those found in multiple sclerosis. The three-dimensional structure of the DA strain, a member of the demyelinating group, has been determined at 2.8 A resolution. As in other picornaviruses, the icosahedral capsid is formed by the packing of wedge-shaped eight-stranded antiparallel beta barrels. The surface of Theiler virus has large star-shaped plateaus at the fivefold axes and broad depressions spanning the twofold axes. Several unusual structural features are clustered near one edge of the depression. These include two finger-like loops projecting from the surface (one formed by residues 78-85 of VP1, and the other formed by residues 56-65 of VP3) and a third loop containing three cysteines (residues 87, 89, and 91 of VP3), which appear to be covalently modified. Most of the sequence differences between the demyelinating and neurovirulent groups that could play a role in determining pathogenesis map to the surface of the star-shaped plateau. The distribution of these sequence differences on the surface of the virion is consistent with models in which the differences in the pathogenesis of the two groups of Theiler viruses are the result of differences in immunological or receptor-mediated recognition processes. Images PMID:1549565

  20. Three-dimensional kinematics of hummingbird flight.

    PubMed

    Tobalske, Bret W; Warrick, Douglas R; Clark, Christopher J; Powers, Donald R; Hedrick, Tyson L; Hyder, Gabriel A; Biewener, Andrew A

    2007-07-01

    Hummingbirds are specialized for hovering flight, and substantial research has explored this behavior. Forward flight is also important to hummingbirds, but the manner in which they perform forward flight is not well documented. Previous research suggests that hummingbirds increase flight velocity by simultaneously tilting their body angle and stroke-plane angle of the wings, without varying wingbeat frequency and upstroke: downstroke span ratio. We hypothesized that other wing kinematics besides stroke-plane angle would vary in hummingbirds. To test this, we used synchronized high-speed (500 Hz) video cameras and measured the three-dimensional wing and body kinematics of rufous hummingbirds (Selasphorus rufus, 3 g, N=5) as they flew at velocities of 0-12 m s(-1) in a wind tunnel. Consistent with earlier research, the angles of the body and the stroke plane changed with velocity, and the effect of velocity on wingbeat frequency was not significant. However, hummingbirds significantly altered other wing kinematics including chord angle, angle of attack, anatomical stroke-plane angle relative to their body, percent of wingbeat in downstroke, wingbeat amplitude, angular velocity of the wing, wingspan at mid-downstroke, and span ratio of the wingtips and wrists. This variation in bird-centered kinematics led to significant effects of flight velocity on the angle of attack of the wing and the area and angles of the global stroke planes during downstroke and upstroke. We provide new evidence that the paths of the wingtips and wrists change gradually but consistently with velocity, as in other bird species that possess pointed wings. Although hummingbirds flex their wings slightly at the wrist during upstroke, their average wingtip-span ratio of 93% revealed that they have kinematically ;rigid' wings compared with other avian species.

  1. Three dimensional study of Lutetia lineaments network

    NASA Astrophysics Data System (ADS)

    Giacomini, Lorenza; Massironi, Matteo; Aboudan, Alessio; Bistacchi, Andrea; Barbieri, Cesare

    2014-05-01

    The Scientific Imaging System for Rosetta, OSIRIS, acquired an imaging sequence of the Lutetia asteroid, allowing detection of a large number of lineaments distributed over most of its surface (Thomas et al., 2012, Planet. Space Sci., 66, 96-124; Massironi et al., 2012, Planet. Space Sci., 66, 125-136). In general these lineaments can be interpreted as the surface expression of discontinuities such as faults or fractures. Several categories of features has been observed, like troughs, scarps, faults, and ridges. These lineaments are generally more than 50 km long and up to 1.2 km in width, and seem to be arranged in systems (e.g. with common orientation). Moreover, in different geological regions of the asteroid a preferred orientation of lineaments can be recognized, but in all regions there are also lineaments which cross the local preferred trend. Noteworthy, lineaments radial to impact craters, that are common on other asteroidal bodies, are mostly absent on Lutetia (Thomas et al., 2012, Planet. Space Sci., 66, 96-124). However, on a non-spherical body it is not obvious to reconstruct the relationships occurring between the different lineaments. Indeed, lineations that appear to be similarly oriented on different asteroid facets could have no correlation at all (Buczkowski et al., 2007, Icarus, 193, 39-52). In this context, the 3D mapping of lineaments, that we performed directly on the Lutetia shape model, allowed us to obtain a three-dimensional model of these structures that have been reconstructed as planes cutting through the asteroid. This innovative methodology allowed us to detect several structures concentric with respect to the North Pole Crater Cluster, suggesting that these lineaments were originated by these impact events. However most lineaments can be reasonably grouped in different systems of lineaments with no obvious correlation with any impact event detected on the imaged surface. This opens new questions on the origin of these structures and

  2. Three-dimensional ring current decay model

    NASA Astrophysics Data System (ADS)

    Fok, Mei Ching; Moore, Thomas E.; Kozyra, Janet U.; Ho, George C.; Hamilton, Douglas C.

    1995-06-01

    This work is an extension of a previous ring current decay model. In the previous work, a two-dimensional kinetic model was constructed to study the temporal variations of the equatorially mirroring ring current ions, considering charge exchange and Coulomb drag losses along drift paths in a magnetic dipole field. In this work, particles with arbitrary pitch angle are considered. By bounce averaging the kinetic equation of the phase space density, information along magnetic field lines can be inferred from the equator. The three-dimensional model is used to simulate the recovery phase of a model great magnetic storm, similar to that which occurred in early February 1986. The initial distribution of ring current ions (at the minimum Dst) is extrapolated to all local times from AMPTE/CCE spacecraft observations on the dawnside and duskside of the inner magnetosphere spanning the L value range L=2.25 to 6.75. Observations by AMPTE/CCE of ring current distributions over subsequent orbits during the storm recovery phase are compared to model outputs. In general, the calculated ion fluxes are consistent with observations, except for H+ fluxes at tens of keV, which are always overestimated. A newly invented visualization idea, designated as a chromogram, is used to display the spatial and energy dependence of the ring current ion diifferential flux. Important features of storm time ring current, such as day-night asymmetry during injection and drift hole on the dayside at low energies (<10 keV), are manifested in the chromogram representation. The pitch angle distribution is well fit by the function, j0(1+Ayn), where y is sine of the equatorial pitch angle. The evolution of the index n is a combined effect of charge exchange loss and particle drift. At low energies (<30 keV), both drift dispersion and charge exchange are important in determining n. ©American Geophysical 1995

  3. Three-dimensional ring current decay model

    NASA Technical Reports Server (NTRS)

    Fok, Mei-Ching; Moore, Thomas E.; Kozyra, Janet U.; Ho, George C.; Hamilton, Douglas C.

    1995-01-01

    This work is an extension of a previous ring current decay model. In the previous work, a two-dimensional kinetic model was constructed to study the temporal variations of the equatorially mirroring ring current ions, considering charge exchange and Coulomb drag losses along drift paths in a magnetic dipole field. In this work, particles with arbitrary pitch angle are considered. By bounce averaging the kinetic equation of the phase space density, information along magnetic field lines can be inferred from the equator. The three-dimensional model is used to simulate the recovery phase of a model great magnetic storm, similar to that which occurred in early February 1986. The initial distribution of ring current ions (at the minimum Dst) is extrapolated to all local times from AMPTE/CCE spacecraft observations on the dawnside and duskside of the inner magnetosphere spanning the L value range L = 2.25 to 6.75. Observations by AMPTE/CCE of ring current distributions over subsequent orbits during the storm recovery phase are compared to model outputs. In general, the calculated ion fluxes are consistent with observations, except for H(+) fluxes at tens of keV, which are always overestimated. A newly invented visualization idea, designated as a chromogram, is used to display the spatial and energy dependence of the ring current ion differential flux. Important features of storm time ring current, such as day-night asymmetry during injection and drift hole on the dayside at low energies (less than 10 keV), are manifested in the chromogram representation. The pitch angle distribution is well fit by the function, J(sub o)(1 + Ay(sup n)), where y is sine of the equatorial pitch angle. The evolution of the index n is a combined effect of charge exchange loss and particle drift. At low energies (less than 30 keV), both drift dispersion and charge exchange are important in determining n.

  4. A hhase I/II trial to evaluate three-dimensional conformal radiation therapy confined to the region of the lumpectomy cavity for Stage I/II breast carcinoma: Initial report of feasibility and reproducibility of Radiation Therapy Oncology Group (RTOG) Study 0319

    SciTech Connect

    Vicini, Frank . E-mail: fvicini@beaumont.edu; Winter, Kathryn M.S.; Straube, William; Wong, John; Pass, Helen; Rabinovitch, Rachel; Chafe, Susan; Arthur, Douglas; Petersen, Ivy; McCormick, Beryl

    2005-12-01

    Background: This prospective study (Radiation Therapy Oncology Group Study 0319) examines the use of three-dimensional conformal external beam radiation therapy to deliver accelerated partial breast irradiation. Reproducibility, as measured by technical feasibility, was the primary end point with the goal of demonstrating whether the technique is widely applicable in a multicenter setting before a Phase III trial is undertaken. Methods and Materials: This study was designed such that if fewer than 5 cases out of the first 42 patients evaluable were scored as unacceptable, the treatment would be considered reproducible. Patients received 38.5 Gy in 3.85 Gy/fraction delivered twice daily. The clinical target volume included the lumpectomy cavity plus a 10-15-mm margin bounded by 5 mm within the skin surface and the lung-chest wall interface. The planning target volume (PTV) included the clinical target volume plus a 10-mm margin. Treatment plans were judged as follows: (1) No variations (total coverage), 95% isodose surface covers 100% of the PTV and all specified critical normal tissue dose-volume histogram (DVH) limits met. (2) Minor variation (marginal coverage), 95% isodose surface covers between {>=}95% and <100% of the PTV. No portion of PTV receives <93% of prescription (isocenter) dose. All specified critical normal tissue DVH limits fall within 5% of the guidelines. (3) Major variation (miss), 95% isodose surface covers <95% of the PTV. Portion of PTV receives <93% of prescription isocenter dose. Any critical normal tissue DVH limit exceeds 5% of the specified value. Results: A total of 58 patients were enrolled on this study between 8/15/03 and 4/30/04, 5 of whom were ineligible or did not receive protocol treatment. Two additional patients were excluded, one because the on-study form was not submitted, and the other because no treatment planning material was submitted. This primary end point analysis is based on the first 42 (out of 51) evaluable patients

  5. Computed Tomography–Guided Interstitial High-Dose-Rate Brachytherapy in Combination With Regional Positive Lymph Node Intensity-Modulated Radiation Therapy in Locally Advanced Peripheral Non–Small Cell Lung Cancer: A Phase 1 Clinical Trial

    SciTech Connect

    Xiang, Li; Zhang, Jian-wen; Lin, Sheng; Luo, Hui-Qun; Wen, Qing-Lian; He, Li-Jia; Shang, Chang-Ling; Ren, Pei-Rong; Yang, Hong-Ru; Pang, Hao-Wen; Yang, Bo; He, Huai-Lin; Chen, Yue; Wu, Jing-Bo

    2015-08-01

    Purpose: To assess the technical safety, adverse events, and efficacy of computed tomography (CT)-guided interstitial high-dose-rate (HDR) brachytherapy in combination with regional positive lymph node intensity modulated radiation therapy in patients with locally advanced peripheral non–small cell lung cancer (NSCLC). Methods and Materials: Twenty-six patients with histologically confirmed NSCLC were enrolled in a prospective, officially approved phase 1 trial. Primary tumors were treated with HDR brachytherapy. A single 30-Gy dose was delivered to the 90% isodose line of the gross lung tumor volume. A total dose of at least 70 Gy was administered to the 95% isodose line of the planning target volume of malignant lymph nodes using 6-MV X-rays. The patients received concurrent or sequential chemotherapy. We assessed treatment efficacy, adverse events, and radiation toxicity. Results: The median follow-up time was 28 months (range, 7-44 months). There were 3 cases of mild pneumothorax but no cases of hemothorax, dyspnea, or pyothorax after the procedure. Grade 3 or 4 acute hematologic toxicity was observed in 5 patients. During follow-up, mild fibrosis around the puncture point was observed on the CT scans of 2 patients, but both patients were asymptomatic. The overall response rates (complete and partial) for the primary mass and positive lymph nodes were 100% and 92.3%, respectively. The 1-year and 2-year overall survival (OS) rates were 90.9% and 67%, respectively, with a median OS of 22.5 months. Conclusion: Our findings suggest that HDR brachytherapy is safe and feasible for peripheral locally advanced NSCLC, justifying a phase 2 clinical trial.

  6. Three-dimensional carbon nanotube based photovoltaics

    NASA Astrophysics Data System (ADS)

    Flicker, Jack

    2011-12-01

    Photovoltaic (PV) cells with a three dimensional (3D) morphology are an exciting new research thrust with promise to create cheaper, more efficient solar cells. This work introduces a new type of 3D PV device based on carbon nanotube (CNT) arrays. These arrays are paired with the thin film heterojunction, CdTe/CdS, to form a complete 3D carbon nanotube PV device (3DCNTPV). Marriage of a complicated 3D structure with production methods traditionally used for planar CdTe solar cell is challenging. This work examines the problems associated with processing these types of cells and systematically alters production methods of the semiconductor layers and electrodes to increase the short circuit current (Isc), eliminate parasitic shunts, and increase the open circuit voltage (Voc). The main benefit of 3D solar cell is the ability to utilize multiple photon interactions with the solar cell surface. The three dimensionality allows photons to interact multiple times with the photoactive material, which increases the absorption and the overall power output over what is possible with a two dimensional (2D) morphology. To quantify the increased power output arising from these multiple photon interactions, a new absorption efficiency term, eta3D, is introduced. The theoretical basis behind this new term and how it relates to the absorption efficiency of a planar cell, eta 2D, is derived. A unique model for the average number of multiple photon impingements, Gamma, is proposed based on three categories of 3D morphology: an infinite trench, an enclosed box, and an array of towers. The derivation of eta3D and Gamma for these 3D PV devices gives a complete picture of the enhanced power output over 2D cells based on CNT array height, pitch, radius, and shape. This theory is validated by monte carlo simulations and experiment. This new type of 3D PV devices has been shown to work experimentally. The first 3DCNTPV cells created posses Isc values of 0.085 to 17.872mA/cm2 and Voc values

  7. Three-dimensional optofluidic device for isolating microbes

    NASA Astrophysics Data System (ADS)

    Keloth, A.; Paterson, L.; Markx, G. H.; Kar, A. K.

    2015-03-01

    Development of efficient methods for isolation and manipulation of microorganisms is essential to study unidentified and yet-to-be cultured microbes originating from a variety of environments. The discovery of novel microbes and their products have the potential to contribute to the development of new medicines and other industrially important bioactive compounds. In this paper we describe the design, fabrication and validation of an optofluidic device capable of redirecting microbes within a flow using optical forces. The device holds promise to enable the high throughput isolation of single microbes for downstream culture and analysis. Optofluidic devices are widely used in clinical research, cell biology and biomedical engineering as they are capable of performing analytical functions such as controlled transportation, compact and rapid processing of nanolitres to millilitres of clinical or biological samples. We have designed and fabricated a three dimensional optofluidic device to control and manipulate microorganisms within a microfluidic channel. The device was fabricated in fused silica by ultrafast laser inscription (ULI) followed by selective chemical etching. The unique three-dimensional capability of ULI is utilized to integrate microfluidic channels and waveguides within the same substrate. The main microfluidic channel in the device constitutes the path of the sample. Optical waveguides are fabricated at right angles to the main microfluidic channel. The potential of the optical scattering force to control and manipulate microorganisms is discussed in this paper. A 980 nm continuous wave (CW) laser source, coupled to the waveguide, is used to exert radiation pressure on the particle and particle migrations at different flow velocities are recorded. As a first demonstration, device functionality is validated using fluorescent microbeads and initial trials with microalgae are presented.

  8. Visualization of Three-Dimensional Nephron Structure With Microcomputed Tomography

    SciTech Connect

    Bentley,M.; Jorgensen, S.; Lerman, L.; Ritman, E.; Romero, J.

    2007-01-01

    The three-dimensional architecture of nephrons in situ and their interrelationship with other nephrons are difficult to visualize by microscopic methods. The present study uses microcomputed X-ray tomography (micro-CT) to visualize intact nephrons in situ. Rat kidneys were perfusion-fixed with buffered formalin and their vasculature was subsequently perfused with radiopaque silicone. Cortical tissue was stained en bloc with osmium tetroxide, embedded in plastic, scanned, and reconstructed at voxel resolutions of 6, 2, and 1 {mu}m. At 6 {mu}m resolution, large blood vessels and glomeruli could be visualized but nephrons and their lumens were small and difficult to visualize. Optimal images were obtained using a synchrotron radiation source at 2 {mu}m resolution where nephron components could be identified, correlated with histological sections, and traced. Proximal tubules had large diameters and opaque walls, whereas distal tubules, connecting tubules, and collecting ducts had smaller diameters and less opaque walls. Blood vessels could be distinguished from nephrons by the luminal presence of radiopaque silicone. Proximal tubules were three times longer than distal tubules. Proximal and distal tubules were tightly coiled in the outer cortex but were loosely coiled in the middle and inner cortex. The connecting tubules had the narrowest diameters of the tubules and converged to form arcades that paralleled the radial vessels as they extended to the outer cortex. These results illustrate a potential use of micro-CT to obtain three-dimensional information about nephron architecture and nephron interrelationships, which could be useful in evaluating experimental tubular hypertrophy, atrophy, and necrosis.

  9. Visualization of three-dimensional nephron structure with microcomputed tomography.

    PubMed

    Bentley, Michael D; Jorgensen, Steven M; Lerman, Lilach O; Ritman, Erik L; Romero, J Carlos

    2007-03-01

    The three-dimensional architecture of nephrons in situ and their interrelationship with other nephrons are difficult to visualize by microscopic methods. The present study uses microcomputed X-ray tomography (micro-CT) to visualize intact nephrons in situ. Rat kidneys were perfusion-fixed with buffered formalin and their vasculature was subsequently perfused with radiopaque silicone. Cortical tissue was stained en bloc with osmium tetroxide, embedded in plastic, scanned, and reconstructed at voxel resolutions of 6, 2, and 1 microm. At 6 microm resolution, large blood vessels and glomeruli could be visualized but nephrons and their lumens were small and difficult to visualize. Optimal images were obtained using a synchrotron radiation source at 2 microm resolution where nephron components could be identified, correlated with histological sections, and traced. Proximal tubules had large diameters and opaque walls, whereas distal tubules, connecting tubules, and collecting ducts had smaller diameters and less opaque walls. Blood vessels could be distinguished from nephrons by the luminal presence of radiopaque silicone. Proximal tubules were three times longer than distal tubules. Proximal and distal tubules were tightly coiled in the outer cortex but were loosely coiled in the middle and inner cortex. The connecting tubules had the narrowest diameters of the tubules and converged to form arcades that paralleled the radial vessels as they extended to the outer cortex. These results illustrate a potential use of micro-CT to obtain three-dimensional information about nephron architecture and nephron interrelationships, which could be useful in evaluating experimental tubular hypertrophy, atrophy, and necrosis.

  10. Structured image reconstruction for three-dimensional ghost imaging lidar.

    PubMed

    Yu, Hong; Li, Enrong; Gong, Wenlin; Han, Shensheng

    2015-06-01

    A structured image reconstruction method has been proposed to obtain high quality images in three-dimensional ghost imaging lidar. By considering the spatial structure relationship between recovered images of scene slices at different longitudinal distances, orthogonality constraint has been incorporated to reconstruct the three-dimensional scenes in remote sensing. Numerical simulations have been performed to demonstrate that scene slices with various sparse ratios can be recovered more accurately by applying orthogonality constraint, and the enhancement is significant especially for ghost imaging with less measurements. A simulated three-dimensional city scene has been successfully reconstructed by using structured image reconstruction in three-dimensional ghost imaging lidar. PMID:26072814

  11. Advanced Three-Dimensional Display System

    NASA Technical Reports Server (NTRS)

    Geng, Jason

    2005-01-01

    A desktop-scale, computer-controlled display system, initially developed for NASA and now known as the VolumeViewer(TradeMark), generates three-dimensional (3D) images of 3D objects in a display volume. This system differs fundamentally from stereoscopic and holographic display systems: The images generated by this system are truly 3D in that they can be viewed from almost any angle, without the aid of special eyeglasses. It is possible to walk around the system while gazing at its display volume to see a displayed object from a changing perspective, and multiple observers standing at different positions around the display can view the object simultaneously from their individual perspectives, as though the displayed object were a real 3D object. At the time of writing this article, only partial information on the design and principle of operation of the system was available. It is known that the system includes a high-speed, silicon-backplane, ferroelectric-liquid-crystal spatial light modulator (SLM), multiple high-power lasers for projecting images in multiple colors, a rotating helix that serves as a moving screen for displaying voxels [volume cells or volume elements, in analogy to pixels (picture cells or picture elements) in two-dimensional (2D) images], and a host computer. The rotating helix and its motor drive are the only moving parts. Under control by the host computer, a stream of 2D image patterns is generated on the SLM and projected through optics onto the surface of the rotating helix. The system utilizes a parallel pixel/voxel-addressing scheme: All the pixels of the 2D pattern on the SLM are addressed simultaneously by laser beams. This parallel addressing scheme overcomes the difficulty of achieving both high resolution and a high frame rate in a raster scanning or serial addressing scheme. It has been reported that the structure of the system is simple and easy to build, that the optical design and alignment are not difficult, and that the

  12. Three dimensional Visualization of Jupiter's Equatorial Region

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Frames from a three dimensional visualization of Jupiter's equatorial region. The images used cover an area of 34,000 kilometers by 11,000 kilometers (about 21,100 by 6,800 miles) near an equatorial 'hotspot' similar to the site where the probe from NASA's Galileo spacecraft entered Jupiter's atmosphere on December 7th, 1995. These features are holes in the bright, reflective, equatorial cloud layer where warmer thermal emission from Jupiter's deep atmosphere can pass through. The circulation patterns observed here along with the composition measurements from the Galileo Probe suggest that dry air may be converging and sinking over these regions, maintaining their cloud-free appearance. The bright clouds to the right of the hotspot as well as the other bright features may be examples of upwelling of moist air and condensation.

    This frame is a view from the southwest looking northeast, from an altitude just above the high haze layer. The streaks in the lower cloud leading towards the hotspot are visible. The upper haze layer is mostly flat, with notable small peaks that can be matched with features in the lower cloud. In reality, these areas may represent a continuous vertical cloud column.

    Galileo is the first spacecraft to image Jupiter in near-infrared light (which is invisible to the human eye) using three filters at 727, 756, and 889 nanometers (nm). Because light at these three wavelengths is absorbed at different altitudes by atmospheric methane, a comparison of the resulting images reveals information about the heights of clouds in Jupiter's atmosphere. This information can be visualized by rendering cloud surfaces with the appropriate height variations.

    The visualization reduces Jupiter's true cloud structure to two layers. The height of a high haze layer is assumed to be proportional to the reflectivity of Jupiter at 889 nm. The height of a lower tropospheric cloud is assumed to be proportional to the reflectivity at 727 nm divided by that at 756

  13. Three dimensional Visualization of Jupiter's Equatorial Region

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Frames from a three dimensional visualization of Jupiter's equatorial region. The images used cover an area of 34,000 kilometers by 11,000 kilometers (about 21,100 by 6,800 miles) near an equatorial 'hotspot' similar to the site where the probe from NASA's Galileo spacecraft entered Jupiter's atmosphere on December 7th, 1995. These features are holes in the bright, reflective, equatorial cloud layer where warmer thermal emission from Jupiter's deep atmosphere can pass through. The circulation patterns observed here along with the composition measurements from the Galileo Probe suggest that dry air may be converging and sinking over these regions, maintaining their cloud-free appearance. The bright clouds to the right of the hotspot as well as the other bright features may be examples of upwelling of moist air and condensation.

    This frame is a view to the northeast, from between the cloud layers and above the streaks in the lower cloud leading towards the hotspot. The upper haze layer has some features that match the lower cloud, such as the bright streak in the foreground of the frame. These are probably thick clouds that span several tens of vertical kilometers.

    Galileo is the first spacecraft to image Jupiter in near-infrared light (which is invisible to the human eye) using three filters at 727, 756, and 889 nanometers (nm). Because light at these three wavelengths is absorbed at different altitudes by atmospheric methane, a comparison of the resulting images reveals information about the heights of clouds in Jupiter's atmosphere. This information can be visualized by rendering cloud surfaces with the appropriate height variations.

    The visualization reduces Jupiter's true cloud structure to two layers. The height of a high haze layer is assumed to be proportional to the reflectivity of Jupiter at 889 nm. The height of a lower tropospheric cloud is assumed to be proportional to the reflectivity at 727 nm divided by that at 756 nm. This model is overly

  14. Three dimensional Visualization of Jupiter's Equatorial Region

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Frames from a three dimensional visualization of Jupiter's equatorial region. The images used cover an area of 34,000 kilometers by 11,000 kilometers (about 21,100 by 6,800 miles) near an equatorial 'hotspot' similar to the site where the probe from NASA's Galileo spacecraft entered Jupiter's atmosphere on December 7th, 1995. These features are holes in the bright, reflective, equatorial cloud layer where warmer thermal emission from Jupiter's deep atmosphere can pass through. The circulation patterns observed here along with the composition measurements from the Galileo Probe suggest that dry air may be converging and sinking over these regions, maintaining their cloud-free appearance. The bright clouds to the right of the hotspot as well as the other bright features may be examples of upwelling of moist air and condensation.

    This frame is a view from above and to the south of the visualized area, showing the entire model. The entire region is overlain by a thin, transparent haze. In places the haze is high and thick, especially to the east (to the right of) the hotspot.

    Galileo is the first spacecraft to image Jupiter in near-infrared light (which is invisible to the human eye) using three filters at 727, 756, and 889 nanometers (nm). Because light at these three wavelengths is absorbed at different altitudes by atmospheric methane, a comparison of the resulting images reveals information about the heights of clouds in Jupiter's atmosphere. This information can be visualized by rendering cloud surfaces with the appropriate height variations.

    The visualization reduces Jupiter's true cloud structure to two layers. The height of a high haze layer is assumed to be proportional to the reflectivity of Jupiter at 889 nm. The height of a lower tropospheric cloud is assumed to be proportional to the reflectivity at 727 nm divided by that at 756 nm. This model is overly simplistic, but is based on more sophisticated studies of Jupiter's cloud structure. The upper

  15. Three dimensional Visualization of Jupiter's Equatorial Region

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Frames from a three dimensional visualization of Jupiter's equatorial region. The images used cover an area of 34,000 kilometers by 11,000 kilometers (about 21,100 by 6,800 miles) near an equatorial 'hotspot' similar to the site where the probe from NASA's Galileo spacecraft entered Jupiter's atmosphere on December 7th, 1995. These features are holes in the bright, reflective, equatorial cloud layer where warmer thermal emission from Jupiter's deep atmosphere can pass through. The circulation patterns observed here along with the composition measurements from the Galileo Probe suggest that dry air may be converging and sinking over these regions, maintaining their cloud-free appearance. The bright clouds to the right of the hotspot as well as the other bright features may be examples of upwelling of moist air and condensation.

    This frame is a view to the northeast, from between the cloud layers and above the streaks in the lower cloud leading towards the hotspot. The hotspot is clearly visible as a deep blue feature. The cloud streaks end near the hotspot, consistent with the idea that clouds traveling along these streak lines descend and evaporate as they approach the hotspot. The upper haze layer is slightly bowed upwards above the hotspot.

    Galileo is the first spacecraft to image Jupiter in near-infrared light (which is invisible to the human eye) using three filters at 727, 756, and 889 nanometers (nm). Because light at these three wavelengths is absorbed at different altitudes by atmospheric methane, a comparison of the resulting images reveals information about the heights of clouds in Jupiter's atmosphere. This information can be visualized by rendering cloud surfaces with the appropriate height variations.

    The visualization reduces Jupiter's true cloud structure to two layers. The height of a high haze layer is assumed to be proportional to the reflectivity of Jupiter at 889 nm. The height of a lower tropospheric cloud is assumed to be proportional

  16. Three dimensional Visualization of Jupiter's Equatorial Region

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Frames from a three dimensional visualization of Jupiter's equatorial region. The images used cover an area of 34,000 kilometers by 11,000 kilometers (about 21,100 by 6,800 miles) near an equatorial 'hotspot' similar to the site where the probe from NASA's Galileo spacecraft entered Jupiter's atmosphere on December 7th, 1995. These features are holes in the bright, reflective, equatorial cloud layer where warmer thermal emission from Jupiter's deep atmosphere can pass through. The circulation patterns observed here along with the composition measurements from the Galileo Probe suggest that dry air may be converging and sinking over these regions, maintaining their cloud-free appearance. The bright clouds to the right of the hotspot as well as the other bright features may be examples of upwelling of moist air and condensation.

    This frame is a view to the southeast, from between the cloud layers and over the north center of the region. The tall white clouds in the lower cloud deck are probably much like large terrestrial thunderclouds. They may be regions where atmospheric water powers vertical convection over large horizontal distances.

    Galileo is the first spacecraft to image Jupiter in near-infrared light (which is invisible to the human eye) using three filters at 727, 756, and 889 nanometers (nm). Because light at these three wavelengths is absorbed at different altitudes by atmospheric methane, a comparison of the resulting images reveals information about the heights of clouds in Jupiter's atmosphere. This information can be visualized by rendering cloud surfaces with the appropriate height variations.

    The visualization reduces Jupiter's true cloud structure to two layers. The height of a high haze layer is assumed to be proportional to the reflectivity of Jupiter at 889 nm. The height of a lower tropospheric cloud is assumed to be proportional to the reflectivity at 727 nm divided by that at 756 nm. This model is overly simplistic, but is based on

  17. Three dimensional Visualization of Jupiter's Equatorial Region

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Frames from a three dimensional visualization of Jupiter's equatorial region. The images used cover an area of 34,000 kilometers by 11,000 kilometers (about 21,100 by 6,800 miles) near an equatorial 'hotspot' similar to the site where the probe from NASA's Galileo spacecraft entered Jupiter's atmosphere on December 7th, 1995. These features are holes in the bright, reflective, equatorial cloud layer where warmer thermal emission from Jupiter's deep atmosphere can pass through. The circulation patterns observed here along with the composition measurements from the Galileo Probe suggest that dry air may be converging and sinking over these regions, maintaining their cloud-free appearance. The bright clouds to the right of the hotspot as well as the other bright features may be examples of upwelling of moist air and condensation.

    This frame is a view to the west, from between the cloud layers and over the patchy white clouds to the east of the hotspot. This is probably an area where moist convection is occurring over large horizontal distances, similar to the atmosphere over the equatorial ocean on Earth. The clouds are high and thick, and are observed to change rapidly over short time scales.

    Galileo is the first spacecraft to image Jupiter in near-infrared light (which is invisible to the human eye) using three filters at 727, 756, and 889 nanometers (nm). Because light at these three wavelengths is absorbed at different altitudes by atmospheric methane, a comparison of the resulting images reveals information about the heights of clouds in Jupiter's atmosphere. This information can be visualized by rendering cloud surfaces with the appropriate height variations.

    The visualization reduces Jupiter's true cloud structure to two layers. The height of a high haze layer is assumed to be proportional to the reflectivity of Jupiter at 889 nm. The height of a lower tropospheric cloud is assumed to be proportional to the reflectivity at 727 nm divided by that at 756

  18. A Phase I/II Trial to Evaluate the Technical Feasibility of Partial Breast Irradiation with Three-Dimensional Conformal Radiation Therapy in Korean Women with Stage I Breast Carcinoma: An Initial Report of the Korean Radiation Therapy Oncology Group (KROG) Study 0804

    PubMed Central

    Jeong, Jae-Uk; Yoon, Jung Han; Park, Min Ho; Yoon, Mee Sun; Song, Ju-Young; Nam, Taek-Keun; Chung, Woong-Ki; Kim, Yong-Hyub; Suh, Chang-Ok; Ahn, Sung-Ja

    2015-01-01

    Purpose This prospective study was designed to verify the technical feasibility of partial breast irradiation in breast cancer patients with small breasts, which are commonly encountered in Korean women. Materials and Methods A total of 40 Gy, administered in 10 fractions on consecutive days (one fraction per day), was prescribed to the isocenters of the fields using three-dimensional conformal radiotherapy (3-DCRT). For all patients, treatment planning and dose parameters strictly adhered to the constraints set forth in the Radiation Therapy Oncology Group (RTOG) 0319 protocol. This study was designed such that if fewer than five of the first 42 evaluable patients received unacceptable scores, the treatment would be considered reproducible. Results Ten treatment plans (23.8%) were determined to have major variations. There was no major variation in planning target volume (PTV) coverage. The ipsilateral and contralateral breast dose limitations were not met in four (9.5%) and four cases (9.5%), respectively. Major variations in ipsilateral and contralateral lung dose limitations were observed in two cases (4.8%). Major variations in the heart and thyroid dose limitations were observed in one (2.4%) and one case (2.4%), respectively. In multivariate analysis, a ratio of PTV to ipsilateral breast volume (PTV/IB) > 0.16 was the only significant factor that statistically affected major variations. Conclusion We concluded that partial breast irradiation using 3-DCRT could not be reproduced in Korean breast cancer patients, particularly small-volumed breast surrogated as PTV/IB > 0.16. The dominant cause was the major variation in surrounding normal breast tissues. PMID:25143050

  19. Dosimetric evaluation of a three-dimensional treatment planning system

    PubMed Central

    Murugan, Appasamy; Valas, Xavier Sidonia; Thayalan, Kuppusamy; Ramasubramanian, Velayudham

    2011-01-01

    The computerized treatment planning system plays a major role in radiation therapy in delivering correct radiation dose to the patients within ±5% as recommended by the ICRU. To evaluate the dosimetric performance of the Treatment Planning system (TPS) with three-dimensional dose calculation algorithm using the basic beam data measured for 6 MV X-rays. Eleven numbers of test cases were created according to the Technical Report Series-430 (TRS 430) and are used to evaluate the TPS in a homogeneous water phantom. These cases involve simple field arrangements as well as the presence of a low-density material in the beam to resemble an air in-homogeneity. Absolute dose measurements were performed for the each case with the MU calculation given by the TPS, and the measured dose is compared with the corresponding TPS calculated dose values. The result yields a percentage difference maximum of 2.38% for all simple test cases. For complex test cases in the presence of in-homogeneity, beam modifiers or beam modifiers with asymmetric fields a maximum percentage difference of 5.94% was observed. This study ensures that the dosimetric calculations performed by the TPS are within the accuracy of ±5% which is very much warranted in patient dose delivery. The test procedures are simple, not only during the installation of TPS, but also repeated at periodic intervals. PMID:21430854

  20. Three-dimensional Model of Tissue and Heavy Ions Effects

    NASA Technical Reports Server (NTRS)

    Ponomarev, Artem L.; Sundaresan, Alamelu; Huff, Janice L.; Cucinotta, Francis A.

    2007-01-01

    A three-dimensional tissue model was incorporated into a new Monte Carlo algorithm that simulates passage of heavy ions in a tissue box . The tissue box was given as a realistic model of tissue based on confocal microscopy images. The action of heavy ions on the cellular matrix for 2- or 3-dimensional cases was simulated. Cells were modeled as a cell culture monolayer in one example, where the data were taken directly from microscopy (2-d cell matrix), and as a multi-layer obtained from confocal microscopy (3-d case). Image segmentation was used to identify cells with precise areas/volumes in an irradiated cell culture monolayer, and slices of tissue with many cell layers. The cells were then inserted into the model box of the simulated physical space pixel by pixel. In the case of modeled tissues (3-d), the tissue box had periodic boundary conditions imposed, which extrapolates the technique to macroscopic volumes of tissue. For the real tissue (3-d), specific spatial patterns for cell apoptosis and necrosis are expected. The cell patterns were modeled based on action cross sections for apoptosis and necrosis estimated from current experimental data. A spatial correlation function indicating a higher spatial concentration of damaged cells from heavy ions relative to the low-LET radiation cell damage pattern is presented. The spatial correlation effects among necrotic cells can help studying microlesions in organs, and probable effects of directionality of heavy ion radiation on epithelium and endothelium.

  1. Three-dimensional image reconstruction for electrical impedance tomography.

    PubMed

    Kleinermann, F; Avis, N J; Judah, S K; Barber, D C

    1996-11-01

    Very little work has been conducted on three-dimensional aspects of electrical impedance tomography (EIT), partly due to the increased computational complexity over the two-dimensional aspects of EIT. Nevertheless, extending EIT to three-dimensional data acquisition and image reconstruction may afford significant advantages such as an increase in the size of the independent data set and improved spatial resolution. However, considerable challenges are associated with the software aspects of three-dimensional EIT systems due to the requirement for accurate three-dimensional forward problem modelling and the derivation of three-dimensional image reconstruction algorithms. This paper outlines the work performed to date to derive a three-dimensional image reconstruction algorithm for EIT based on the inversion of the sensitivity matrix approach for a finite right circular cylinder. A comparison in terms of the singular-value spectra and the singular vectors between the sensitivity matrices for a three-dimensional cylinder and a two-dimensional disc has been performed. This comparison shows that the three-dimensional image reconstruction algorithm recruits more central information at lower condition numbers than the two-dimensional image reconstruction algorithm.

  2. Three-dimensional plasma equilibrium near a separatrix

    SciTech Connect

    Reiman, A.H.; Pomphrey, N.; Boozer, A.H.

    1988-08-01

    The limiting behavior of a general three-dimensional MHD equilibrium near a separatrix is calculated explicitly. No expansions in ..beta.. or assumptions about island widths are made. Implications of the results for the numerical calculation of such equilibria, are discussed, as well as for issues concerning the existence of three-dimensional MHD equilibria. 16 refs., 2 figs.

  3. Three-dimensional imaging of the myocardium with isotopes

    NASA Technical Reports Server (NTRS)

    Budinger, T. F.

    1975-01-01

    Three methods of imaging the three-dimensional distribution of isotopes in the myocardium are discussed. Three-dimensional imaging was examined using multiple Anger-camera views. Longitudinal tomographic images with compensation for blurring were studied. Transverse-section reconstruction using coincidence detection of annihilation gammas from positron emitting isotopes was investigated.

  4. Pathogen propagation in cultured three-dimensional tissue mass

    NASA Technical Reports Server (NTRS)

    Goodwin, Thomas J. (Inventor); Spaulding, Glenn F. (Inventor); Wolf, David A. (Inventor)

    2000-01-01

    A process for propagating a pathogen in a three-dimensional tissue mass cultured at microgravity conditions in a culture vessel containing culture media and a culture matrix is provided. The three-dimensional tissue mass is inoculated with a pathogen and pathogen replication in the cells of the tissue mass achieved.

  5. Three-dimensional winged nanocone optical antennas.

    PubMed

    Huttunen, Mikko J; Lindfors, Klas; Andriano, Domenico; Mäkitalo, Jouni; Bautista, Godofredo; Lippitz, Markus; Kauranen, Martti

    2014-06-15

    We introduce 3D optical antennas based on winged nanocones. The antennas support particle plasmon oscillations with current distributions that facilitate transformation of transverse far-field radiation to strong longitudinal local fields near the cone apices. We characterize the optical responses of the antennas by their extinction spectra and by second-harmonic generation microscopy with cylindrical vector beams. The results demonstrate a new 3D polarization-controllable optical antenna for applications in apertureless near-field microscopy, spectroscopy, and plasmonic sensing.

  6. Three-dimensional Einstein-Klein-Gordon system in characteristic numerical relativity

    SciTech Connect

    Barreto, W.; Silva, A. da; Lehner, L.; Gomez, R.; Rosales, L.; Winicour, J.

    2005-03-15

    We incorporate a massless scalar field into a three-dimensional code for the characteristic evolution of the gravitational field. The extended three-dimensional code for the Einstein-Klein-Gordon system is calibrated to be second-order convergent. It provides an accurate calculation of the gravitational and scalar radiation at infinity. As an application, we simulate the fully nonlinear evolution of an asymmetric scalar pulse of ingoing radiation propagating toward an interior Schwarzschild black hole and compute the backscattered scalar and gravitational outgoing radiation patterns. The amplitudes of the scalar and gravitational outgoing radiation modes exhibit the predicted power law scaling with respect to the amplitude of the initial data. For the scattering of an axisymmetric scalar field, the final ring down matches the complex frequency calculated perturbatively for the l=2 quasinormal mode.

  7. Secondary instability in three-dimensional magnetic reconnection

    NASA Technical Reports Server (NTRS)

    Dahlburg, R. B.; Antiochos, S. K.; Zang, T. A.

    1992-01-01

    We consider the transition to turbulence in three-dimensional reconnection of a magnetic neutral sheet. We find that the transition can occur via a three-step process. First, the sheet undergoes the usual tearing instability. Second, the tearing mode saturates to form a two-dimensional quasi-steady state. Third, this secondary equilibrium is itself unstable when it is perturbed by three-dimensional disturbances. Most of this paper is devoted to the analysis and simulation of the three-dimensional linear stability properties of the two-dimensional saturated tearing layer. The numerical simulations are performed with a semi-implicit, pseudospectral-Fourier collocation algorithm. We identify a three-dimensional secondary linear stability which grows on the ideal timescale. An examination of the modal energetics reveals that the largest energy transfer is from the mean field to the three-dimensional field, with the two-dimensional field acting as a catalyst.

  8. Occlusion-free monocular three-dimensional vision system

    NASA Astrophysics Data System (ADS)

    Theodoracatos, Vassilios E.

    1994-10-01

    This paper describes a new, occlusion-free, monocular three-dimensional vision system. A matrix of light beams (lasers, fiber optics, etc.), substantially parallel to the optic axis of the lens of a video camera, is projected onto a scene. The corresponding coordinates of the perspective image generated on the video-camera sensor, the focal length of the camera lens, and the lateral position of the projected beams of light are used to determine the 'perspective depth' z* of the three-dimensional real image in the space between the lens and the image plane. Direct inverse perspective transformations are used to reconstruct the three- dimensional real-world scene. This system can lead to the development of three-dimensional real-image sensing devices for manufacturing, medical, and defense-related applications. If combined with existing technology, it has high potential for the development of three- dimensional television.

  9. Coherent diffraction imaging: consistency of the assembled three-dimensional distribution.

    PubMed

    Tegze, Miklós; Bortel, Gábor

    2016-07-01

    The short pulses of X-ray free-electron lasers can produce diffraction patterns with structural information before radiation damage destroys the particle. From the recorded diffraction patterns the structure of particles or molecules can be determined on the nano- or even atomic scale. In a coherent diffraction imaging experiment thousands of diffraction patterns of identical particles are recorded and assembled into a three-dimensional distribution which is subsequently used to solve the structure of the particle. It is essential to know, but not always obvious, that the assembled three-dimensional reciprocal-space intensity distribution is really consistent with the measured diffraction patterns. This paper shows that, with the use of correlation maps and a single parameter calculated from them, the consistency of the three-dimensional distribution can be reliably validated. PMID:27357847

  10. On the attenuation of sound by three-dimensionally segmented acoustic liners in a rectangular duct

    NASA Technical Reports Server (NTRS)

    Koch, W.

    1979-01-01

    Axial segmentation of acoustically absorbing liners in rectangular, circular or annual duct configurations is a very useful concept for obtaining higher noise attenuation with respect to the bandwidth of absorption as well as the maximum attenuation. As a consequence, advanced liner concepts are proposed which induce a modal energy transfer in both cross-sectional directions to further reduce the noise radiated from turbofan engines. However, these advanced liner concepts require three-dimensional geometries which are difficult to treat theoretically. A very simple three-dimensional problem is investigated analytically. The results show a strong dependence on the positioning of the liner for some incident source modes while the effect of three-dimensional segmentation appears to be negligible over the frequency range considered.

  11. Virtual three-dimensional blackboard: three-dimensional finger tracking with a single camera

    NASA Astrophysics Data System (ADS)

    Wu, Andrew; Hassan-Shafique, Khurram; Shah, Mubarak; da Vitoria Lobo, N.

    2004-01-01

    We present a method for three-dimensional (3D) tracking of a human finger from a monocular sequence of images. To recover the third dimension from the two-dimensional images, we use the fact that the motion of the human arm is highly constrained owing to the dependencies between elbow and forearm and the physical constraints on joint angles. We use these anthropometric constraints to derive a 3D trajectory of a gesticulating arm. The system is fully automated and does not require human intervention. The system presented can be used as a visualization tool, as a user-input interface, or as part of some gesture-analysis system in which 3D information is important.

  12. Three-dimensional aerodynamic shape optimization using discrete sensitivity analysis

    NASA Technical Reports Server (NTRS)

    Burgreen, Gregory W.

    1995-01-01

    An aerodynamic shape optimization procedure based on discrete sensitivity analysis is extended to treat three-dimensional geometries. The function of sensitivity analysis is to directly couple computational fluid dynamics (CFD) with numerical optimization techniques, which facilitates the construction of efficient direct-design methods. The development of a practical three-dimensional design procedures entails many challenges, such as: (1) the demand for significant efficiency improvements over current design methods; (2) a general and flexible three-dimensional surface representation; and (3) the efficient solution of very large systems of linear algebraic equations. It is demonstrated that each of these challenges is overcome by: (1) employing fully implicit (Newton) methods for the CFD analyses; (2) adopting a Bezier-Bernstein polynomial parameterization of two- and three-dimensional surfaces; and (3) using preconditioned conjugate gradient-like linear system solvers. Whereas each of these extensions independently yields an improvement in computational efficiency, the combined effect of implementing all the extensions simultaneously results in a significant factor of 50 decrease in computational time and a factor of eight reduction in memory over the most efficient design strategies in current use. The new aerodynamic shape optimization procedure is demonstrated in the design of both two- and three-dimensional inviscid aerodynamic problems including a two-dimensional supersonic internal/external nozzle, two-dimensional transonic airfoils (resulting in supercritical shapes), three-dimensional transport wings, and three-dimensional supersonic delta wings. Each design application results in realistic and useful optimized shapes.

  13. Advanced three-dimensional Eulerian hydrodynamic algorithm development

    SciTech Connect

    Rider, W.J.; Kothe, D.B.; Mosso, S.

    1998-11-01

    This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The purpose of this project is to investigate, implement, and evaluate algorithms that have high potential for improving the robustness, fidelity and accuracy of three-dimensional Eulerian hydrodynamic simulations. Eulerian computations are necessary to simulate a number of important physical phenomena ranging from the molding process for metal parts to nuclear weapons safety issues to astrophysical phenomena such as that associated with a Type 2 supernovae. A number of algorithmic issues were explored in the course of this research including interface/volume tracking, surface physics integration, high resolution integration techniques, multilevel iterative methods, multimaterial hydrodynamics and coupling radiation with hydrodynamics. This project combines core strengths of several Laboratory divisions. The project has high institutional benefit given the renewed emphasis on numerical simulations in Science-Based Stockpile Stewardship and the Accelerated Strategic Computing Initiative and LANL`s tactical goals related to high performance computing and simulation.

  14. The Three-dimensional Structure of the Eta Carinae Homunculus

    NASA Technical Reports Server (NTRS)

    Steffen, W.; Teodoro, M.; Madura, T.I.; Groh, J.H.; Gull, T.R.; Mehner, A.; Corcoran, M.F.; Damineli, A.; Hamaguchi, K.

    2014-01-01

    We investigate, using the modeling code SHAPE, the three-dimensional structure of the bipolar Homunculus nebula surrounding Eta Carinae as mapped by new ESO VLT/X-Shooter observations of the H2 (lambda) = 2.12125 micrometers emission line. Our results reveal for the first time important deviations from the axisymmetric bipolar morphology: 1) circumpolar trenches in each lobe positioned point-symmetrically from the center and 2) offplanar protrusions in the equatorial region from each lobe at longitudinal (approximately 55 degrees) and latitudinal (10 degrees to 20 degrees) distances from the projected apastron direction of the binary orbit. The angular distance between the protrusions (approximately 110 degrees) is similar to the angular extent of each polar trench (approximately 130 degrees) and nearly equal to the opening angle of the wind-wind collision cavity (approximately 110 degrees). As in previous studies, we confirm a hole near the centre of each polar lobe and no detectable near-IR H2 emission from the thin optical skirt seen prominently in visible imagery. We conclude that the interaction between the outflows and/or radiation from the central binary stars and their orientation in space has had, and possibly still has, a strong influence on the Homunculus. This implies that prevailing theoretical models of the Homunculus are incomplete as most assume a single star origin that produces an axisymmetric nebula.We discuss how the newly found features might be related to the Homunculus ejection, the central binary and the interacting stellar winds.

  15. Three-dimensional hydrodynamic simulations of L2 Puppis

    NASA Astrophysics Data System (ADS)

    Chen, Zhuo; Nordhaus, Jason; Frank, Adam; Blackman, Eric G.; Balick, Bruce

    2016-08-01

    Recent observations of the L2 Puppis system suggest that this Mira-like variable may be in the early stages of forming a bipolar planetary nebula. As one of nearest and brightest asymptotic giant branch (AGB) stars, thought be a binary, L2 Puppis serves as a benchmark object for studying the late-stages of stellar evolution. We perform global, three-dimensional, adaptive-mesh-refinement hydrodynamic simulations of the L2 Puppis system with ASTROBEAR. We use the radiative transfer code RADMC-3D to construct the broad-band spectral energy distribution and synthetic observational images from our simulations. Given the reported binary parameters, we are able to reproduce the current observational data if a short pulse of dense material is released from the AGB star with a velocity sufficient to escape the primary but not the binary. Such a situation could result from a thermal pulse, be induced by a periastron passage of the secondary, or could be launched if the primary ingests a planet.

  16. Three-dimensional lattice Boltzmann model for electrodynamics.

    PubMed

    Mendoza, M; Muñoz, J D

    2010-11-01

    In this paper we introduce a three-dimensional Lattice-Boltzmann model that recovers in the continuous limit the Maxwell equations in materials. In order to build conservation equations with antisymmetric tensors, like the Faraday law, the model assigns four auxiliary vectors to each velocity vector. These auxiliary vectors, when combined with the distribution functions, give the electromagnetic fields. The evolution is driven by the usual Bhatnager-Gross-Krook (BGK) collision rule, but with a different form for the equilibrium distribution functions. This lattice Bhatnager-Gross-Krook (LBGK) model allows us to consider for both dielectrics and conductors with realistic parameters, and therefore it is adequate to simulate the most diverse electromagnetic problems, like the propagation of electromagnetic waves (both in dielectric media and in waveguides), the skin effect, the radiation pattern of a small dipole antenna and the natural frequencies of a resonant cavity, all with 2% accuracy. Actually, it shows to be one order of magnitude faster than the original Finite-difference time-domain (FDTD) formulation by Yee to reach the same accuracy. It is, therefore, a valuable alternative to simulate electromagnetic fields and opens lattice Boltzmann for a broad spectrum of new applications in electrodynamics.

  17. Advancements for Three-Dimensional Remote Sensing of the Atmosphere

    NASA Astrophysics Data System (ADS)

    Martin, William George Kulesz

    Climate modeling efforts depend on remote sensing observations of clouds and aerosols in the atmosphere. This dissertation presents a foundation for using three-dimensional (3D) remote sensing techniques to retrieve cloud and aerosol properties in complex cloud fields. The initial research was aimed at establishing a set of single-scattering properties that could be used in subsequent 3D remote sensing applications. A theoretical stability analysis was used to evaluate what information about the particulate scattering material could be determined from in situ radiance and polarization measurements, and particle size and refractive index were retrieved from synthetic measurements with noise levels comparable to those of existing laboratory instruments. Subsequent research focused on the techniques necessary to retrieve 3D atmosphere and surface properties from images taken by an airborne or space-borne instrument. With the goal of using 3D retrieval methods to extend monitoring capabilities to regions with broken cloud fields, we formulated an efficient procedure for using codes that solve the 3D vector radiative transfer equation (VRTE) to adjust atmosphere and surface properties to fit multi-angle/multi-pixel polarimetric measurements of the atmosphere. Taken together, these two bodies of work contribute to ongoing research which focuses on developing new methods for retrieving aerosols in complex 3D cloud fields, and may extend monitoring capabilities to these currently unresolved scenes.

  18. Three-dimensional scanning transmission electron microscopy of biological specimens.

    PubMed

    de Jonge, Niels; Sougrat, Rachid; Northan, Brian M; Pennycook, Stephen J

    2010-02-01

    A three-dimensional (3D) reconstruction of the cytoskeleton and a clathrin-coated pit in mammalian cells has been achieved from a focal-series of images recorded in an aberration-corrected scanning transmission electron microscope (STEM). The specimen was a metallic replica of the biological structure comprising Pt nanoparticles 2-3 nm in diameter, with a high stability under electron beam radiation. The 3D dataset was processed by an automated deconvolution procedure. The lateral resolution was 1.1 nm, set by pixel size. Particles differing by only 10 nm in vertical position were identified as separate objects with greater than 20% dip in contrast between them. We refer to this value as the axial resolution of the deconvolution or reconstruction, the ability to recognize two objects, which were unresolved in the original dataset. The resolution of the reconstruction is comparable to that achieved by tilt-series transmission electron microscopy. However, the focal-series method does not require mechanical tilting and is therefore much faster. 3D STEM images were also recorded of the Golgi ribbon in conventional thin sections containing 3T3 cells with a comparable axial resolution in the deconvolved dataset.

  19. Three-dimensional scanning transmission electron microscopy of biological specimens

    SciTech Connect

    De Jonge, Niels; Sougrat, Rachid; Northan, Brian; Pennycook, Stephen J

    2010-01-01

    A three-dimensional (3D) reconstruction of the cytoskeleton and a clathrin-coated pit in mammalian cells has been achieved from a focal-series of images recorded in an aberration-corrected scanning transmission electron microscope (STEM). The specimen was a metallic replica of the biological structure comprising Pt nanoparticles 2 - 3 nm in diameter, with a high stability under electron beam radiation. The 3D dataset was processed by an automated deconvolution procedure. The lateral resolution was 1.1 nm, set by pixel size. Particles differing by only 10 nm in vertical position were identified as separate objects with greater than 20% dip in contrast between them. We refer to this value as the axial resolution of the deconvolution or reconstruction, the ability to recognize two objects, which were unresolved in the original data set. The precision of the height determination was 0.2 nm. The resolution of the reconstruction is comparable to that achieved by tilt-series transmission electron microscopy (TEM). However, the focal-series method does not require mechanical tilting and is therefore much faster. 3D STEM images were also recorded of the Golgi ribbon in conventional thin sections containing 3T3 cells with a comparable axial resolution in the deconvolved data set.

  20. Three-dimensional assessment of brain tissue morphology

    NASA Astrophysics Data System (ADS)

    Müller, Bert; Germann, Marco; Jeanmonod, Daniel; Morel, Anne

    2006-08-01

    The microstructure of brain tissues becomes visible using different types of optical microscopy after the tissue sectioning. This preparation procedure introduces stress and strain in the anisotropic and inhomogeneous soft tissue slices, which are several 10 μm thick. Consequently, the three-dimensional dataset, generated out of the two-dimensional images with lateral submicrometer resolution, needs algorithms to correct the deformations, which can be significant for mellow tissue such as brain segments. The spatial resolution perpendicular to the slices is much worse with respect to the lateral sub-micrometer resolution. Therefore, we propose as complementary method the synchrotron-radiation-based micro computed tomography (SRμCT), which avoids any kind of preparation artifacts due to sectioning and histological processing and yields true micrometer resolution in the three orthogonal directions. The visualization of soft matter by the use of SRμCT, however, is often based on elaborate staining protocols, since the tissue exhibits (almost) the same x-ray absorption as the surrounding medium. Therefore, it is unexpected that human tissue from the pons and the medulla oblongata in phosphate buffer show several features such as the blood vessels and the inferior olivary nucleus without staining. The value of these tomograms lies especially in the precise non-rigid registration of the different sets of histological slices. Applications of this method to larger pieces of brain tissue, such as the human thalamus are planned in the context of stereotactic functional neurosurgery.

  1. Three-dimensional X-ray micro-velocimetry

    PubMed Central

    Lee, Wah-Keat; Fezzaa, Kamel; Uemura, Tomomasa

    2011-01-01

    A direct measurement of three-dimensional X-ray velocimetry with micrometer spatial resolution is presented. The key to this development is the use of a Laue crystal as an X-ray beam splitter and mirror. Three-dimensional flow velocities in a 0.4 mm-diameter tubing were recorded, with <5 µm spatial resolution and speeds of 0.7 mm s−1. This development paves the way for three-dimensional velocimetry in many cases where visible-light techniques are not effective, such as multiphase flow or flow of optically opaque liquids. PMID:21335921

  2. Cervical Gross Tumor Volume Dose Predicts Local Control Using Magnetic Resonance Imaging/Diffusion-Weighted Imaging—Guided High-Dose-Rate and Positron Emission Tomography/Computed Tomography—Guided Intensity Modulated Radiation Therapy

    SciTech Connect

    Dyk, Pawel; Jiang, Naomi; Sun, Baozhou; DeWees, Todd A.; Fowler, Kathryn J.; Narra, Vamsi; Garcia-Ramirez, Jose L.; Schwarz, Julie K.; Grigsby, Perry W.

    2014-11-15

    Purpose: Magnetic resonance imaging/diffusion weighted-imaging (MRI/DWI)-guided high-dose-rate (HDR) brachytherapy and {sup 18}F-fluorodeoxyglucose (FDG) — positron emission tomography/computed tomography (PET/CT)-guided intensity modulated radiation therapy (IMRT) for the definitive treatment of cervical cancer is a novel treatment technique. The purpose of this study was to report our analysis of dose-volume parameters predicting gross tumor volume (GTV) control. Methods and Materials: We analyzed the records of 134 patients with International Federation of Gynecology and Obstetrics stages IB1-IVB cervical cancer treated with combined MRI-guided HDR and IMRT from July 2009 to July 2011. IMRT was targeted to the metabolic tumor volume and lymph nodes by use of FDG-PET/CT simulation. The GTV for each HDR fraction was delineated by use of T2-weighted or apparent diffusion coefficient maps from diffusion-weighted sequences. The D100, D90, and Dmean delivered to the GTV from HDR and IMRT were summed to EQD2. Results: One hundred twenty-five patients received all irradiation treatment as planned, and 9 did not complete treatment. All 134 patients are included in this analysis. Treatment failure in the cervix occurred in 24 patients (18.0%). Patients with cervix failures had a lower D100, D90, and Dmean than those who did not experience failure in the cervix. The respective doses to the GTV were 41, 58, and 136 Gy for failures compared with 67, 99, and 236 Gy for those who did not experience failure (P<.001). Probit analysis estimated the minimum D100, D90, and Dmean doses required for ≥90% local control to be 69, 98, and 260 Gy (P<.001). Conclusions: Total dose delivered to the GTV from combined MRI-guided HDR and PET/CT-guided IMRT is highly correlated with local tumor control. The findings can be directly applied in the clinic for dose adaptation to maximize local control.

  3. Characterization of a new radiochromic three-dimensional dosimeter

    PubMed Central

    Guo, P. Y.; Adamovics, J. A.; Oldham, M.

    2006-01-01

    The development of intensity-modulated radiotherapy (IMRT) has created a clear need for a dosimeter that can accurately and conveniently measure dose distributions in three dimensions to assure treatment quality. PRESAGE™ is a new three dimensional (3D) dosimetry material consisting of an optically clear polyurethane matrix, containing a leuco dye that exhibits a radiochromic response when exposed to ionizing radiation. A number of potential advantages accrue over other gel dosimeters, including insensitivity to oxygen, radiation induced light absorption contrast rather than scattering contrast, and a solid texture amenable to machining to a variety of shapes and sizes without the requirement of an external container. In this paper, we introduce an efficient method to investigate the basic properties of a 3D dosimetry material that exhibits an optical dose response. The method is applied here to study the key aspects of the optical dose response of PRESAGE™: linearity, dose rate dependency, reproducibility, stability, spectral changes in absorption, and temperature effects. PRESAGE™ was prepared in 1×1×4.5 cm3 optical cuvettes for convenience and was irradiated by both photon and electron beams to different doses, dose rates, and energies. Longer PRESAGE™ columns (2 ×2×13 cm3) were formed without an external container, for measurements of photon and high energy electron depth-dose curves. A linear optical scanning technique was used to detect the depth distribution of radiation induced optical density (OD) change along the PRESAGE™ columns and cuvettes. Measured depth-OD curves were compared with percent depth dose (PDD). Results indicate that PRESAGE™ has a linear optical response to radiation dose (with a root mean square error of ∼1%), little dependency on dose rate (∼2%), high intrabatch reproducibility (<2%), and can be stable (∼2%) during 2 hours to 2 days post irradiation. Accurate PRESAGE™ dosimetry requires temperature control

  4. THREE-DIMENSIONAL MODELING OF HOT JUPITER ATMOSPHERIC FLOWS

    SciTech Connect

    Rauscher, Emily; Menou, Kristen

    2010-05-10

    We present a three-dimensional hot Jupiter model, extending from 200 bar to 1 mbar, using the Intermediate General Circulation Model from the University of Reading. Our horizontal spectral resolution is T31 (equivalent to a grid of 48 x 96), with 33 logarithmically spaced vertical levels. A simplified (Newtonian) scheme is employed for the radiative forcing. We adopt a physical setup nearly identical to the model of HD 209458b by Cooper and Showman to facilitate a direct model inter-comparison. Our results are broadly consistent with theirs but significant differences also emerge. The atmospheric flow is characterized by a super-rotating equatorial jet, transonic wind speeds, and eastward advection of heat away from the dayside. We identify a dynamically induced temperature inversion ('stratosphere') on the planetary dayside and find that temperatures at the planetary limb differ systematically from local radiative equilibrium values, a potential source of bias for transit spectroscopic interpretations. While our model atmosphere is quasi-identical to that of Cooper and Showman and we solve the same meteorological equations, we use different algorithmic methods, spectral-implicit versus grid-explicit, which are known to yield fully consistent results in the Earth modeling context. The model discrepancies identified here indicate that one or both numerical methods do not faithfully capture all of the atmospheric dynamics at work in the hot Jupiter context. We highlight the emergence of a shock-like feature in our model, much like that reported recently by Showman et al., and suggest that improved representations of energy conservation may be needed in hot Jupiter atmospheric models, as emphasized by Goodman.

  5. A Three-dimensional Camera: Development and Applications of a Three-dimensional Image Measurement System

    NASA Astrophysics Data System (ADS)

    Lu, Cunwei; Kamitomo, Hiroya; Sun, Ke; Tsujino, Kazuhiro; Cho, Genki

    Three-dimensional (3-D) image measurement is a technique that uses a digital camera to determine the shape and dimensions of the surface of an object. Although it has been studied for a long time, various problems still remain to be solved for practical applications. The goal of our research is to solve these problems and to develop a 3-D camera that can be used for practical 3-D image measurements. This paper analyzes the problems associated with the conventional technology and introduces development goals for the new 3-D camera. The key techniques of this 3-D camera are explained, including techniques for optimizing the intensity-modulation pattern projection, controlling the projection pattern intensity, determining the projection position, and controlling the stripe period. The system is evaluated and some examples of applications are given. The proposed 3-D camera can automatically adjust for variations in an object's size, form, surface color, and reflection characteristics and it can measure non-stationary objects. Consequently, it has the potential to be used in a wide range of applications including product quality control, human measurement, and face recognition.

  6. Improving Students' Sense of Three-Dimensional Shapes.

    ERIC Educational Resources Information Center

    Leeson, Neville J.

    1994-01-01

    Describes activities to be used with fifth and sixth graders to improve students' spatial sense with respect to three-dimensional shapes. Includes the use of cubes, triangular prisms, tetrahedrons, and square pyramids. (MKR)

  7. Three-dimensional Simulation of Backward Raman Amplification

    SciTech Connect

    A.A. Balakin; G.M. Fraiman; N.J. Fisch

    2005-11-12

    Three-dimensional (3-D) simulations for the Backward Raman Amplification (BRA) are presented. The images illustrate the effects of pump depletion, pulse diffraction, non-homogeneous plasma density, and plasma ionization.

  8. Visual Chemistry: Three-Dimensional Perception of Chemical Structures.

    ERIC Educational Resources Information Center

    Balaban, Alexandru T.

    1999-01-01

    Discusses in great detail aspects connected with the visual and mental processing of chemical images. Presents various types of conventions for translating three-dimensional objects into two-dimensional representations. (Author/CCM)

  9. Three-Dimensional Lithium-Ion Battery Model (Presentation)

    SciTech Connect

    Kim, G. H.; Smith, K.

    2008-05-01

    Nonuniform battery physics can cause unexpected performance and life degradations in lithium-ion batteries; a three-dimensional cell performance model was developed by integrating an electrode-scale submodel using a multiscale modeling scheme.

  10. Construction of Three Dimensional Solutions for the Maxwell Equations

    NASA Technical Reports Server (NTRS)

    Yefet, A.; Turkel, E.

    1998-01-01

    We consider numerical solutions for the three dimensional time dependent Maxwell equations. We construct a fourth order accurate compact implicit scheme and compare it to the Yee scheme for free space in a box.

  11. Three-dimensional reconstructions of solid surfaces using conventional microscopes.

    PubMed

    Ficker, Tomáš; Martišek, Dalibor

    2016-01-01

    The three-dimensional digital replicas of solid surfaces are subject of interest of different branches of science and technology. The present paper in its introductory parts brings an overview of the various microscopic reconstructive techniques based on optical sectioning. The main attention is devoted to conventional reconstruction methods and especially to that one employing the Fourier transform. The three-dimensional replicas of this special reconstructive frequency method are compared graphically and numerically with the three-dimensional replicas of the confocal method. Based on the comparative study it has been concluded that the quality of the conventional replicas of surfaces possessing textures of intermediate height irregularities is acceptable and almost comparable with the quality of confocal replicas. This study is relevant both for identifying a convenient technique that provides good qualities of three-dimensional replicas and for selecting the hardware whose price is affordable even for small research groups studying rougher surface textures.

  12. Three-dimensional reconstructions of solid surfaces using conventional microscopes.

    PubMed

    Ficker, Tomáš; Martišek, Dalibor

    2016-01-01

    The three-dimensional digital replicas of solid surfaces are subject of interest of different branches of science and technology. The present paper in its introductory parts brings an overview of the various microscopic reconstructive techniques based on optical sectioning. The main attention is devoted to conventional reconstruction methods and especially to that one employing the Fourier transform. The three-dimensional replicas of this special reconstructive frequency method are compared graphically and numerically with the three-dimensional replicas of the confocal method. Based on the comparative study it has been concluded that the quality of the conventional replicas of surfaces possessing textures of intermediate height irregularities is acceptable and almost comparable with the quality of confocal replicas. This study is relevant both for identifying a convenient technique that provides good qualities of three-dimensional replicas and for selecting the hardware whose price is affordable even for small research groups studying rougher surface textures. PMID:26381761

  13. Analysis and validation of carbohydrate three-dimensional structures

    SciTech Connect

    Lütteke, Thomas

    2009-02-01

    The article summarizes the information that is gained from and the errors that are found in carbohydrate structures in the Protein Data Bank. Validation tools that can locate these errors are described. Knowledge of the three-dimensional structures of the carbohydrate molecules is indispensable for a full understanding of the molecular processes in which carbohydrates are involved, such as protein glycosylation or protein–carbohydrate interactions. The Protein Data Bank (PDB) is a valuable resource for three-dimensional structural information on glycoproteins and protein–carbohydrate complexes. Unfortunately, many carbohydrate moieties in the PDB contain inconsistencies or errors. This article gives an overview of the information that can be obtained from individual PDB entries and from statistical analyses of sets of three-dimensional structures, of typical problems that arise during the analysis of carbohydrate three-dimensional structures and of the validation tools that are currently available to scientists to evaluate the quality of these structures.

  14. Direct Linear Transformation Method for Three-Dimensional Cinematography

    ERIC Educational Resources Information Center

    Shapiro, Robert

    1978-01-01

    The ability of Direct Linear Transformation Method for three-dimensional cinematography to locate points in space was shown to meet the accuracy requirements associated with research on human movement. (JD)

  15. Effect of three-dimensionality on compressible mixing

    SciTech Connect

    Papamoschou, D. )

    1992-02-01

    Existing experimental data and hypotheses on the growth rates of compressible and incompressible turbulent shear layers are used to estimate the effect of three-dimensionality in the turbulent mixing enhancement in compressible shear flows that is critically important to the efficiency of scramjet powerplants. The general trend is found to be a decrease in growth rate with increasing three-dimensionality, excepting only the restricted regime, where the growth-rate increase is modest. 9 refs.

  16. Alignment-free three-dimensional optical metamaterials.

    PubMed

    Zhao, Yang; Shi, Jinwei; Sun, Liuyang; Li, Xiaoqin; Alù, Andrea

    2014-03-01

    Three-dimensional optical metamaterials based on multilayers typically rely on critical vertical alignment to achieve the desired functionality. Here the conditions under which three-dimensional metamaterials with different functionalities may be realized without constraints on alignment are analyzed and demonstrated experimentally. This study demonstrates that the release of alignment constraints for multilayered metamaterials is allowed, while their anomalous interaction with light is preserved.

  17. Initialization and Simulation of Three-Dimensional Aircraft Wake Vortices

    NASA Technical Reports Server (NTRS)

    Ash, Robert L.; Zheng, Z. C.

    1997-01-01

    This paper studies the effects of axial velocity profiles on vortex decay, in order to properly initialize and simulate three-dimensional wake vortex flow. Analytical relationships are obtained based on a single vortex model and computational simulations are performed for a rather practical vortex wake, which show that the single vortex analytical relations can still be applicable at certain streamwise sections of three-dimensional wake vortices.

  18. Three dimensional separation effects on a simplified wind turbine blade

    SciTech Connect

    Soerensen, N.N.; Michelsen, J.A.

    1996-10-01

    A qualitative investigation of the three dimensional effects on a twisted non-rotating wing without tapering is performed, using a general purpose Navier-Stokes solver. Different location of twist center as well as different twist ratios are examined for fully attached flow. The case of a partially separated blade is investigated as well. The three dimensional effects are primarily identified by comparing the lift and C{sub p} distribution of the blade with the two dimensional counterpart.

  19. Three-dimensional scanning microscopy through thin turbid media.

    PubMed

    Yang, Xin; Hsieh, Chia-Lung; Pu, Ye; Psaltis, Demetri

    2012-01-30

    We demonstrate three-dimensional imaging through a thin turbid medium using digital phase conjugation of the second harmonic signal emitted from a beacon nanoparticle. The digitally phase-conjugated focus scans the volume in the vicinity of its initial position through numerically manipulated phase patterns projected onto the spatial light modulator. Accurate three dimensional images of a fluorescent sample placed behind a turbid medium are obtained.

  20. Integrated Aeromechanics with Three-Dimensional Solid-Multibody Structures

    NASA Technical Reports Server (NTRS)

    Datta, Anubhav; Johnson, Wayne

    2014-01-01

    A full three-dimensional finite element-multibody structural dynamic solver is coupled to a three-dimensional Reynolds-averaged Navier-Stokes solver for the prediction of integrated aeromechanical stresses and strains on a rotor blade in forward flight. The objective is to lay the foundations of all major pieces of an integrated three-dimensional rotor dynamic analysis - from model construction to aeromechanical solution to stress/strain calculation. The primary focus is on the aeromechanical solution. Two types of three-dimensional CFD/CSD interfaces are constructed for this purpose with an emphasis on resolving errors from geometry mis-match so that initial-stage approximate structural geometries can also be effectively analyzed. A three-dimensional structural model is constructed as an approximation to a UH-60A-like fully articulated rotor. The aerodynamic model is identical to the UH-60A rotor. For preliminary validation measurements from a UH-60A high speed flight is used where CFD coupling is essential to capture the advancing side tip transonic effects. The key conclusion is that an integrated aeromechanical analysis is indeed possible with three-dimensional structural dynamics but requires a careful description of its geometry and discretization of its parts.

  1. Advancing three-dimensional MEMS by complimentary laser micro manufacturing

    NASA Astrophysics Data System (ADS)

    Palmer, Jeremy A.; Williams, John D.; Lemp, Tom; Lehecka, Tom M.; Medina, Francisco; Wicker, Ryan B.

    2006-01-01

    This paper describes improvements that enable engineers to create three-dimensional MEMS in a variety of materials. It also provides a means for selectively adding three-dimensional, high aspect ratio features to pre-existing PMMA micro molds for subsequent LIGA processing. This complimentary method involves in situ construction of three-dimensional micro molds in a stand-alone configuration or directly adjacent to features formed by x-ray lithography. Three-dimensional micro molds are created by micro stereolithography (MSL), an additive rapid prototyping technology. Alternatively, three-dimensional features may be added by direct femtosecond laser micro machining. Parameters for optimal femtosecond laser micro machining of PMMA at 800 nanometers are presented. The technical discussion also includes strategies for enhancements in the context of material selection and post-process surface finish. This approach may lead to practical, cost-effective 3-D MEMS with the surface finish and throughput advantages of x-ray lithography. Accurate three-dimensional metal microstructures are demonstrated. Challenges remain in process planning for micro stereolithography and development of buried features following femtosecond laser micro machining.

  2. Ordered three-dimensional interconnected nanoarchitectures in anodic porous alumina

    PubMed Central

    Martín, Jaime; Martín-González, Marisol; Fernández, Jose Francisco; Caballero-Calero, Olga

    2014-01-01

    Three-dimensional nanostructures combine properties of nanoscale materials with the advantages of being macro-sized pieces when the time comes to manipulate, measure their properties, or make a device. However, the amount of compounds with the ability to self-organize in ordered three-dimensional nanostructures is limited. Therefore, template-based fabrication strategies become the key approach towards three-dimensional nanostructures. Here we report the simple fabrication of a template based on anodic aluminum oxide, having a well-defined, ordered, tunable, homogeneous 3D nanotubular network in the sub 100 nm range. The three-dimensional templates are then employed to achieve three-dimensional, ordered nanowire-networks in Bi2Te3 and polystyrene. Lastly, we demonstrate the photonic crystal behavior of both the template and the polystyrene three-dimensional nanostructure. Our approach may establish the foundations for future high-throughput, cheap, photonic materials and devices made of simple commodity plastics, metals, and semiconductors. PMID:25342247

  3. Three Dimensional Probability Distributions of the Interplanetary Magnetic Field

    NASA Astrophysics Data System (ADS)

    Podesta, J. J.

    2014-12-01

    Empirical probability density functions (PDFs) of the interplanetary magnetic field (IMF) have been derived from spacecraft data since the early years of the space age. A survey of the literature shows that past studies have investigated the separate Cartesian components of the magnetic field, the vector magnitude, and the direction of the IMF by means of one-dimensional or two-dimensional PDFs. But, to my knowledge, there exist no studies which investigate the three dimensional nature of the IMF by means of three dimensional PDFs, either in (Bx,By,Bz)(B_x,B_y,B_z)-coordinates or (BR,BT,BN)(B_R,B_T,B_N)-coordinates or some other appropriate system of coordinates. Likewise, there exist no studies which investigate three dimensional PDFs of magnetic field fluctuations, that is, vector differences bmB(t+τ)-bmB(t)bm{B}(t+tau)-bm{B}(t). In this talk, I shall present examples of three dimensional PDFs obtained from spacecraft data that demonstrate the solar wind magnetic field possesses a very interesting spatial structure that, to my knowledge, has not previously been identified. Perhaps because of the well known model of Barnes (1981) in which the magnitude of the IMF remains constant, it may be commonly believed that there is nothing new to learn from a full three dimensional PDF. To the contrary, there is much to learn from the investigation of three dimensional PDFs of the solar wind plasma velocity and the magnetic field, as well as three dimensional PDFs of their fluctuations. Knowledge of these PDFs will not only improve understanding of solar wind physics, it is an essential prerequisite for the construction of realistic models of the stochastic time series measured by a single spacecraft, one of the longstanding goals of space physics research. In addition, three dimensional PDFs contain valuable information about the anisotropy of solar wind fluctuations in three dimensional physical space, information that may help identify the reason why the three

  4. Electron tomography, three-dimensional Fourier analysis and colour prediction of a three-dimensional amorphous biophotonic nanostructure

    PubMed Central

    Shawkey, Matthew D.; Saranathan, Vinodkumar; Pálsdóttir, Hildur; Crum, John; Ellisman, Mark H.; Auer, Manfred; Prum, Richard O.

    2009-01-01

    Organismal colour can be created by selective absorption of light by pigments or light scattering by photonic nanostructures. Photonic nanostructures may vary in refractive index over one, two or three dimensions and may be periodic over large spatial scales or amorphous with short-range order. Theoretical optical analysis of three-dimensional amorphous nanostructures has been challenging because these structures are difficult to describe accurately from conventional two-dimensional electron microscopy alone. Intermediate voltage electron microscopy (IVEM) with tomographic reconstruction adds three-dimensional data by using a high-power electron beam to penetrate and image sections of material sufficiently thick to contain a significant portion of the structure. Here, we use IVEM tomography to characterize a non-iridescent, three-dimensional biophotonic nanostructure: the spongy medullary layer from eastern bluebird Sialia sialis feather barbs. Tomography and three-dimensional Fourier analysis reveal that it is an amorphous, interconnected bicontinuous matrix that is appropriately ordered at local spatial scales in all three dimensions to coherently scatter light. The predicted reflectance spectra from the three-dimensional Fourier analysis are more precise than those predicted by previous two-dimensional Fourier analysis of transmission electron microscopy sections. These results highlight the usefulness, and obstacles, of tomography in the description and analysis of three-dimensional photonic structures. PMID:19158016

  5. Numerical Improvement of The Three-dimensional Boundary Element Method

    NASA Astrophysics Data System (ADS)

    Ortiz-Aleman, C.; Gil-Zepeda, A.; Sánchez-Sesma, F. J.; Luzon-Martinez, F.

    2001-12-01

    Boundary element methods have been applied to calculate the seismic response of various types of geological structures. Dimensionality reduction and a relatively easy fulfillment of radiation conditions at infinity are recognized advantages over domain approaches. Indirect Boundary Element Method (IBEM) formulations give rise to large systems of equations, and the considerable amount of operations required for solving them suggest the possibility of getting some benefit from exploitation of sparsity patterns. In this article, a brief study on the structure of the linear systems derived from the IBEM method is carried out. Applicability of a matrix static condensation algorithm to the inversion of the IBEM coefficient matrix is explored, in order to optimize the numerical burden of such method. Seismic response of a 3-D alluvial valley of irregular shape, as originally proposed by Sánchez-Sesma and Luzon (1995), was computed and comparisons on time consumption and memory allocation are established. An alternative way to deal with those linear systems is the use of threshold criteria for the truncation of the coefficient matrix, which implies the solution of sparse approximations instead of the original full IBEM systems (Ortiz-Aleman et al., 1998). Performance of this optimized approach is evaluated on its application to the case of a three-dimensional alluvial basin with irregular shape. Transfer functions were calculated for the frequency range from 0 to 1.25 Hz. Inversion of linear systems by using this algorithm lead to significant saving on computer time and memory allocation relative to the original IBEM formulation. Results represent an extension in the range of application of the IBEM method.

  6. Three-dimensional coherent X-ray diffractive imaging of whole frozen-hydrated cells

    DOE PAGES

    Rodriguez, Jose A.; Xu, Rui; Chen, Chien -Chun; Huang, Zhifeng; Jiang, Huaidong; Chen, Allan L.; Raines, Kevin S.; Pryor, Jr., Alan; Nam, Daewoong; Wiegart, Lutz; et al

    2015-09-01

    Here, a structural understanding of whole cells in three dimensions at high spatial resolution remains a significant challenge and, in the case of X-rays, has been limited by radiation damage. By alleviating this limitation, cryogenic coherent diffractive imaging (cryo-CDI) can in principle be used to bridge the important resolution gap between optical and electron microscopy in bio-imaging. Here, the first experimental demonstration of cryo-CDI for quantitative three-dimensional imaging of whole frozen-hydrated cells using 8 Kev X-rays is reported. As a proof of principle, a tilt series of 72 diffraction patterns was collected from a frozen-hydrated Neospora caninum cell and themore » three-dimensional mass density of the cell was reconstructed and quantified based on its natural contrast. This three-dimensional reconstruction reveals the surface and internal morphology of the cell, including its complex polarized sub-cellular structure. Finally, it is believed that this work represents an experimental milestone towards routine quantitative three-dimensional imaging of whole cells in their natural state with spatial resolutions in the tens of nanometres.« less

  7. Three-dimensional coherent X-ray diffractive imaging of whole frozen-hydrated cells

    SciTech Connect

    Rodriguez, Jose A.; Xu, Rui; Chen, Chien -Chun; Huang, Zhifeng; Jiang, Huaidong; Chen, Allan L.; Raines, Kevin S.; Pryor, Jr., Alan; Nam, Daewoong; Wiegart, Lutz; Song, Changyong; Madsen, Anders; Chushkin, Yuriy; Zontone, Federico; Bradley, Peter J.; Miao, Jianwei

    2015-09-01

    Here, a structural understanding of whole cells in three dimensions at high spatial resolution remains a significant challenge and, in the case of X-rays, has been limited by radiation damage. By alleviating this limitation, cryogenic coherent diffractive imaging (cryo-CDI) can in principle be used to bridge the important resolution gap between optical and electron microscopy in bio-imaging. Here, the first experimental demonstration of cryo-CDI for quantitative three-dimensional imaging of whole frozen-hydrated cells using 8 Kev X-rays is reported. As a proof of principle, a tilt series of 72 diffraction patterns was collected from a frozen-hydrated Neospora caninum cell and the three-dimensional mass density of the cell was reconstructed and quantified based on its natural contrast. This three-dimensional reconstruction reveals the surface and internal morphology of the cell, including its complex polarized sub-cellular structure. Finally, it is believed that this work represents an experimental milestone towards routine quantitative three-dimensional imaging of whole cells in their natural state with spatial resolutions in the tens of nanometres.

  8. Three-dimensional coherent X-ray diffractive imaging of whole frozen-hydrated cells

    PubMed Central

    Rodriguez, Jose A.; Xu, Rui; Chen, Chien-Chun; Huang, Zhifeng; Jiang, Huaidong; Chen, Allan L.; Raines, Kevin S.; Pryor Jr, Alan; Nam, Daewoong; Wiegart, Lutz; Song, Changyong; Madsen, Anders; Chushkin, Yuriy; Zontone, Federico; Bradley, Peter J.; Miao, Jianwei

    2015-01-01

    A structural understanding of whole cells in three dimensions at high spatial resolution remains a significant challenge and, in the case of X-rays, has been limited by radiation damage. By alleviating this limitation, cryogenic coherent diffractive imaging (cryo-CDI) can in principle be used to bridge the important resolution gap between optical and electron microscopy in bio-imaging. Here, the first experimental demonstration of cryo-CDI for quantitative three-dimensional imaging of whole frozen-hydrated cells using 8 keV X-rays is reported. As a proof of principle, a tilt series of 72 diffraction patterns was collected from a frozen-hydrated Neospora caninum cell and the three-dimensional mass density of the cell was reconstructed and quantified based on its natural contrast. This three-dimensional reconstruction reveals the surface and internal morphology of the cell, including its complex polarized sub-cellular structure. It is believed that this work represents an experimental milestone towards routine quantitative three-dimensional imaging of whole cells in their natural state with spatial resolutions in the tens of nanometres. PMID:26306199

  9. Finnish spectrolite as high-dose gamma detector

    NASA Astrophysics Data System (ADS)

    Antonio, Patrícia L.; Caldas, Linda V. E.

    2015-11-01

    A natural material called spectrolite, from Finland, was studied in this work. The purpose was to test it in gamma radiation beams to verify its performance as a high-dose detector. From this material, pellets were manufactured with two different concentrations of Teflon and spectrolite, and their responses were verified using two luminescent techniques: thermoluminescence (TL) and optically stimulated luminescence (OSL). The TL and OSL signals were evaluated by means of characterization tests of the material response, after exposure to a nominal absorbed dose interval of 5 Gy to 10 kGy. The results obtained, for both concentrations, showed a good performance of this material in beams of high-dose gamma radiation. Both techniques were utilized in order to investigate the properties of the spectrolite+Teflon samples for different applications.

  10. Volume-scalable high-brightness three-dimensional visible light source

    SciTech Connect

    Subramania, Ganapathi; Fischer, Arthur J; Wang, George T; Li, Qiming

    2014-02-18

    A volume-scalable, high-brightness, electrically driven visible light source comprises a three-dimensional photonic crystal (3DPC) comprising one or more direct bandgap semiconductors. The improved light emission performance of the invention is achieved based on the enhancement of radiative emission of light emitters placed inside a 3DPC due to the strong modification of the photonic density-of-states engendered by the 3DPC.

  11. A moving observer in a three-dimensional world

    PubMed Central

    2016-01-01

    For many tasks such as retrieving a previously viewed object, an observer must form a representation of the world at one location and use it at another. A world-based three-dimensional reconstruction of the scene built up from visual information would fulfil this requirement, something computer vision now achieves with great speed and accuracy. However, I argue that it is neither easy nor necessary for the brain to do this. I discuss biologically plausible alternatives, including the possibility of avoiding three-dimensional coordinate frames such as ego-centric and world-based representations. For example, the distance, slant and local shape of surfaces dictate the propensity of visual features to move in the image with respect to one another as the observer's perspective changes (through movement or binocular viewing). Such propensities can be stored without the need for three-dimensional reference frames. The problem of representing a stable scene in the face of continual head and eye movements is an appropriate starting place for understanding the goal of three-dimensional vision, more so, I argue, than the case of a static binocular observer. This article is part of the themed issue ‘Vision in our three-dimensional world’. PMID:27269608

  12. Biodynamic profiling of three-dimensional tissue growth techniques

    NASA Astrophysics Data System (ADS)

    Sun, Hao; Merrill, Dan; Turek, John; Nolte, David

    2016-03-01

    Three-dimensional tissue culture presents a more biologically relevant environment in which to perform drug development than conventional two-dimensional cell culture. However, obtaining high-content information from inside three dimensional tissue has presented an obstacle to rapid adoption of 3D tissue culture for pharmaceutical applications. Biodynamic imaging is a high-content three-dimensional optical imaging technology based on low-coherence interferometry and digital holography that uses intracellular dynamics as high-content image contrast. In this paper, we use biodynamic imaging to compare pharmaceutical responses to Taxol of three-dimensional multicellular spheroids grown by three different growth techniques: rotating bioreactor, hanging-drop and plate-grown spheroids. The three growth techniques have systematic variations among tissue cohesiveness and intracellular activity and consequently display different pharmacodynamics under identical drug dose conditions. The in vitro tissue cultures are also compared to ex vivo living biopsies. These results demonstrate that three-dimensional tissue cultures are not equivalent, and that drug-response studies must take into account the growth method.

  13. A moving observer in a three-dimensional world.

    PubMed

    Glennerster, Andrew

    2016-06-19

    For many tasks such as retrieving a previously viewed object, an observer must form a representation of the world at one location and use it at another. A world-based three-dimensional reconstruction of the scene built up from visual information would fulfil this requirement, something computer vision now achieves with great speed and accuracy. However, I argue that it is neither easy nor necessary for the brain to do this. I discuss biologically plausible alternatives, including the possibility of avoiding three-dimensional coordinate frames such as ego-centric and world-based representations. For example, the distance, slant and local shape of surfaces dictate the propensity of visual features to move in the image with respect to one another as the observer's perspective changes (through movement or binocular viewing). Such propensities can be stored without the need for three-dimensional reference frames. The problem of representing a stable scene in the face of continual head and eye movements is an appropriate starting place for understanding the goal of three-dimensional vision, more so, I argue, than the case of a static binocular observer.This article is part of the themed issue 'Vision in our three-dimensional world'.

  14. A moving observer in a three-dimensional world.

    PubMed

    Glennerster, Andrew

    2016-06-19

    For many tasks such as retrieving a previously viewed object, an observer must form a representation of the world at one location and use it at another. A world-based three-dimensional reconstruction of the scene built up from visual information would fulfil this requirement, something computer vision now achieves with great speed and accuracy. However, I argue that it is neither easy nor necessary for the brain to do this. I discuss biologically plausible alternatives, including the possibility of avoiding three-dimensional coordinate frames such as ego-centric and world-based representations. For example, the distance, slant and local shape of surfaces dictate the propensity of visual features to move in the image with respect to one another as the observer's perspective changes (through movement or binocular viewing). Such propensities can be stored without the need for three-dimensional reference frames. The problem of representing a stable scene in the face of continual head and eye movements is an appropriate starting place for understanding the goal of three-dimensional vision, more so, I argue, than the case of a static binocular observer.This article is part of the themed issue 'Vision in our three-dimensional world'. PMID:27269608

  15. High dose rate brachytherapy for oral cancer

    PubMed Central

    YamazakI, Hideya; Yoshida, Ken; Yoshioka, Yasuo; Shimizutani, Kimishige; Furukawa, Souhei; Koizumi, Masahiko; Ogawa, Kazuhiko

    2013-01-01

    Brachytherapy results in better dose distribution compared with other treatments because of steep dose reduction in the surrounding normal tissues. Excellent local control rates and acceptable side effects have been demonstrated with brachytherapy as a sole treatment modality, a postoperative method, and a method of reirradiation. Low-dose-rate (LDR) brachytherapy has been employed worldwide for its superior outcome. With the advent of technology, high-dose-rate (HDR) brachytherapy has enabled health care providers to avoid radiation exposure. This therapy has been used for treating many types of cancer such as gynecological cancer, breast cancer, and prostate cancer. However, LDR and pulsed-dose-rate interstitial brachytherapies have been mainstays for head and neck cancer. HDR brachytherapy has not become widely used in the radiotherapy community for treating head and neck cancer because of lack of experience and biological concerns. On the other hand, because HDR brachytherapy is less time-consuming, treatment can occasionally be administered on an outpatient basis. For the convenience and safety of patients and medical staff, HDR brachytherapy should be explored. To enhance the role of this therapy in treatment of head and neck lesions, we have reviewed its outcomes with oral cancer, including Phase I/II to Phase III studies, evaluating this technique in terms of safety and efficacy. In particular, our studies have shown that superficial tumors can be treated using a non-invasive mold technique on an outpatient basis without adverse reactions. The next generation of image-guided brachytherapy using HDR has been discussed. In conclusion, although concrete evidence is yet to be produced with a sophisticated study in a reproducible manner, HDR brachytherapy remains an important option for treatment of oral cancer. PMID:23179377

  16. Three-dimensional calculation of windmill surface pressures

    NASA Astrophysics Data System (ADS)

    Valarezo, W. O.; Liebeck, R. H.

    A three-dimensional panel method capable of computing the flow about propellers is applied to the prediction of blade surface pressures for windmill configurations. Computed surface pressures at various conditions are compared to experimental data and to predictions based on Blade Element Theory (BET). The panel method is used to compute flows about complex three-dimensional geometries and to numerically predict trends not easily obtainable from experimental efforts due to the difficulty and expense of the required instrumentation. These new three-dimensional computations exhibit better agreement with experimental data than standard BET-based predictions. Also, the reported increment in lift carrying capability of rotating lifting surfaces over surfaces in rectilinear translational motion is captured by the panel method and is shown to be an inviscid effect.

  17. Three-dimensional, three-component wall-PIV

    NASA Astrophysics Data System (ADS)

    Berthe, André; Kondermann, Daniel; Christensen, Carolyn; Goubergrits, Leonid; Garbe, Christoph; Affeld, Klaus; Kertzscher, Ulrich

    2010-06-01

    This paper describes a new time-resolved three-dimensional, three-component (3D-3C) measurement technique called wall-PIV. It was developed to assess near wall flow fields and shear rates near non-planar surfaces. The method is based on light absorption according to Beer-Lambert’s law. The fluid containing a molecular dye and seeded with buoyant particles is illuminated by a monochromatic, diffuse light. Due to the dye, the depth of view is limited to the near wall layer. The three-dimensional particle positions can be reconstructed by the intensities of the particle’s projection on an image sensor. The flow estimation is performed by a new algorithm, based on learned particle trajectories. Possible sources of measurement errors related to the wall-PIV technique are analyzed. The accuracy analysis was based on single particle experiments and a three-dimensional artificial data set simulating a rotating sphere.

  18. Coupled particle dispersion by three-dimensional vortex structures

    SciTech Connect

    Troutt, T.R.; Chung, J.N.; Crowe, C.T.

    1996-12-31

    The primary objective of this research program is to obtain understanding concerning the role of three-dimensional vortex structures in the dispersion of particles and droplets in free shear flows. This research program builds on previous studies which focused on the nature of particle dispersion in large scale quasi two-dimensional vortex structures. This investigation employs time dependent experimental and numerical techniques to provide information concerning the particulate dispersion produced by three dimensional vortex structures in free shear layers. The free shear flows investigated include modified plane mixing layers, and modified plane wakes. The modifications to these flows involve slight perturbations to the initiation boundary conditions such that three-dimensional vortex structures are rapidly generated by the experimental and numerical flow fields. Recent results support the importance of these vortex structures in the particle dispersion process.

  19. Imaging protein three-dimensional nanocrystals with cryo-EM.

    PubMed

    Nederlof, Igor; Li, Yao Wang; van Heel, Marin; Abrahams, Jan Pieter

    2013-05-01

    Flash-cooled three-dimensional crystals of the small protein lysozyme with a thickness of the order of 100 nm were imaged by 300 kV cryo-EM on a Falcon direct electron detector. The images were taken close to focus and to the eye appeared devoid of contrast. Fourier transforms of the images revealed the reciprocal lattice up to 3 Å resolution in favourable cases and up to 4 Å resolution for about half the crystals. The reciprocal-lattice spots showed structure, indicating that the ordering of the crystals was not uniform. Data processing revealed details at higher than 2 Å resolution and indicated the presence of multiple mosaic blocks within the crystal which could be separately processed. The prospects for full three-dimensional structure determination by electron imaging of protein three-dimensional nanocrystals are discussed. PMID:23633595

  20. Time of Closest Approach in Three-Dimensional Airspace

    NASA Technical Reports Server (NTRS)

    Munoz, Cesar A.; Narkawicz, Anthony J.

    2010-01-01

    In air traffic management, the aircraft separation requirement is defined by a minimum horizontal distance and a minimum vertical distance that the aircraft have to maintain. Since this requirement defines a cylinder around each aircraft rather than a sphere, the three-dimensional Euclidean distance does not provide an appropriate basis for the definition of time of closest approach. For instance, conflicting aircraft are not necessarily in loss of separation at the time of closest three-dimensional Euclidean distance. This paper proposes a definition of time of closest approach that characterizes conflicts in a three-dimensional airspace. The proposed time is defined as the time that minimizes a distance metric called cylindrical norm. An algorithm that computes the time of closest approach between two aircraft is provided and the formal verification of its main properties is reported.