Science.gov

Sample records for high-field autosolitons formation

  1. Autosolitons in applied physics and traffic flow

    SciTech Connect

    Kerner, B.S.

    1996-06-01

    A review of investigations of autosolitons in nonlinear systems which are of interest for the applied physics and for the transportation research is presented. Autosolitons are solitary intrinsic states which can be formed in a broad class of physical, chemical, biological dissipative distributed media and in traffic flow. Properties of autosolitons which are general for physical systems and for traffic flow will be discussed. Based on results of recent investigations of traffic jams in traffic flow, a comparison of nonlinear characteristics of traffic jams and with nonlinear properties of autosolitons which can be formed in active systems with diffusion will be given. Forms, properties, processes of evolution of autosolitons in traffic flow, in semiconductors and in gas discharge plasma are considered. {copyright} {ital 1996 American Institute of Physics.}

  2. PHYSICAL BASIS OF QUANTUM ELECTRONICS: Bifurcation analysis of laser autosolitons

    NASA Astrophysics Data System (ADS)

    Vladimirov, A. G.; Rozanov, Nikolai N.; Fedorov, S. V.; Khodova, G. V.

    1997-11-01

    An investigation is reported of one-dimensional stationary localised radiation structures ('laser autosolitons'), which appear in a wide-aperture laser with a saturable absorber under conditions of hard lasing excitation. Bifurcation theory methods are used to find the range of existence of single autosolitons and of their coupled states. It is shown that such structures correspond to a transverse dependence of the field amplitude which is either symmetric and node-free or antisymmetric and has a single node. An infinite set of single autosolitons with various widths and transverse amplitude profiles is predicted. It is shown that there is an infinite set of 'two-soliton' structures differing in respect of the distance between the component autosolitons.

  3. OPTICAL COMMUNICATION: Simulation of autosoliton optical pulses in high-speed fibreoptic communication systems

    NASA Astrophysics Data System (ADS)

    Latkin, A. I.

    2005-03-01

    The propagation of a pulse in a fibreoptic communication link with periodically included regenerators — nonlinear optical loop mirrors, is studied. The autosoliton propagation regime of the optical pulse is revealed. It is shown that the inclusion of a ring mirror to the communication link leads to a substantial increase in the transmission distance of the pulse at a small negative average dispersion in the link.

  4. Formation of high-field magnetic white dwarfs from common envelopes.

    PubMed

    Nordhaus, Jason; Wellons, Sarah; Spiegel, David S; Metzger, Brian D; Blackman, Eric G

    2011-02-22

    The origin of highly magnetized white dwarfs has remained a mystery since their initial discovery. Recent observations indicate that the formation of high-field magnetic white dwarfs is intimately related to strong binary interactions during post-main-sequence phases of stellar evolution. If a low-mass companion, such as a planet, brown dwarf, or low-mass star, is engulfed by a post-main-sequence giant, gravitational torques in the envelope of the giant lead to a reduction of the companion's orbit. Sufficiently low-mass companions in-spiral until they are shredded by the strong gravitational tides near the white dwarf core. Subsequent formation of a super-Eddington accretion disk from the disrupted companion inside a common envelope can dramatically amplify magnetic fields via a dynamo. Here, we show that these disk-generated fields are sufficiently strong to explain the observed range of magnetic field strengths for isolated, high-field magnetic white dwarfs. A higher-mass binary analogue may also contribute to the origin of magnetar fields. PMID:21300910

  5. Formation of high-field magnetic white dwarfs from common envelopes.

    PubMed

    Nordhaus, Jason; Wellons, Sarah; Spiegel, David S; Metzger, Brian D; Blackman, Eric G

    2011-02-22

    The origin of highly magnetized white dwarfs has remained a mystery since their initial discovery. Recent observations indicate that the formation of high-field magnetic white dwarfs is intimately related to strong binary interactions during post-main-sequence phases of stellar evolution. If a low-mass companion, such as a planet, brown dwarf, or low-mass star, is engulfed by a post-main-sequence giant, gravitational torques in the envelope of the giant lead to a reduction of the companion's orbit. Sufficiently low-mass companions in-spiral until they are shredded by the strong gravitational tides near the white dwarf core. Subsequent formation of a super-Eddington accretion disk from the disrupted companion inside a common envelope can dramatically amplify magnetic fields via a dynamo. Here, we show that these disk-generated fields are sufficiently strong to explain the observed range of magnetic field strengths for isolated, high-field magnetic white dwarfs. A higher-mass binary analogue may also contribute to the origin of magnetar fields.

  6. Formation of high-field magnetic white dwarfs from common envelopes

    PubMed Central

    Nordhaus, Jason; Wellons, Sarah; Spiegel, David S.; Metzger, Brian D.; Blackman, Eric G.

    2011-01-01

    The origin of highly magnetized white dwarfs has remained a mystery since their initial discovery. Recent observations indicate that the formation of high-field magnetic white dwarfs is intimately related to strong binary interactions during post-main-sequence phases of stellar evolution. If a low-mass companion, such as a planet, brown dwarf, or low-mass star, is engulfed by a post-main-sequence giant, gravitational torques in the envelope of the giant lead to a reduction of the companion’s orbit. Sufficiently low-mass companions in-spiral until they are shredded by the strong gravitational tides near the white dwarf core. Subsequent formation of a super-Eddington accretion disk from the disrupted companion inside a common envelope can dramatically amplify magnetic fields via a dynamo. Here, we show that these disk-generated fields are sufficiently strong to explain the observed range of magnetic field strengths for isolated, high-field magnetic white dwarfs. A higher-mass binary analogue may also contribute to the origin of magnetar fields. PMID:21300910

  7. A new inclination shallowing correction of the Mauch Chunk Formation of Pennsylvania, based on high-field AIR results: Implications for the Carboniferous North American APW path and Pangea reconstructions

    NASA Astrophysics Data System (ADS)

    Bilardello, Dario; Kodama, Kenneth P.

    2010-10-01

    A new magnetic anisotropy study was performed on samples of the Lower Carboniferous Mauch Chunk Formation of Pennsylvania. These red beds had been sampled for an inclination shallowing study by Tan and Kodama (2002), however, application of a high-field anisotropy of isothermal remanence magnetization (hf-AIR) technique specifically designed to measure the anisotropy of hematite provides considerably different results from those previously reported. The newly measured fabric has smaller anisotropy (~ 9-17% as opposed to ~ 25-40%) and shows a pronounced ENE-WSW magnetic lineation that is sub-parallel to the trend of the Appalachians and interpretable as a hematite intersection lineation that occurred during local NNW-directed shortening. The measured magnetic fabric yields a new inclination correction with a corrected paleopole that is in better agreement with recently corrected Carboniferous paleopoles than the previously corrected Mauch Chunk paleopole, defining a more consistent APW path. The corrected paleopoles allow calculation of new mean Early (~ 325 Ma) and Late (~ 312 Ma) Carboniferous inclination-corrected paleopoles for North America, which can be compared to coeval, but uncorrected, paleopoles from Gondwana. Results suggest a Pangea B assemblage unless inclination shallowing is considered for Gondwana. Estimating an inclination correction for Gondwana sedimentary rock-derived paleopoles permits a Pangea A-type assemblage at higher southern latitudes than previous reconstructions, which we term Pangea A3.

  8. A new inclination shallowing correction of the Mauch Chunk Formation of Pennsylvania, based on high field-AIR results: Implications for the Carboniferous North American APW path and Pangea reconstructions

    NASA Astrophysics Data System (ADS)

    Bilardello, D.; Kodama, K. P.

    2010-12-01

    A new rock-magnetic study was performed on samples of the Lower Carboniferous Mauch Chunk Formation of Pennsylvania. These red beds had been sampled for an inclination shallowing study by Tan and Kodama (2002). High anisotropy values lead Kodama (2009) to suspect that the Formation had been affected by strain. However, more detailed rock-magnetic measurements also show that both magnetite and hematite contribute to the remanence, leading to the application of a high field anisotropy of isothermal remanence magnetization (hf-AIR) technique specifically designed to isolate the anisotropy of the hematite, the characteristic remanence carrier. The newly measured fabric has a smaller anisotropy than Kodama (2009) observed (~9-17% as opposed to ~25-40%) and shows a pronounced ENE-WSW magnetic lineation that is sub-parallel to the trend of the Appalachians and interpretable as a hematite intersection lineation that occurred during local NNW-directed shortening. Results also yield a much different AIR/ anisotropy of magnetic susceptibility (AMS) relationship than previously reported. We attribute the differences in the AIR/AMS relationship to varying concentrations of magnetite. Because the AIR/AMS relationship has been used to constrain the individual particle anisotropy we suggest this approach to determine grain anisotropy is invalid, at least until the AIR/AMS relationship for single domain hematite only is measured. The measured magnetic fabric yields a new inclination correction with a corrected paleopole that is in better agreement with recently corrected Carboniferous paleopoles than the previously corrected Mauch Chunk paleopole, defining a more consistent APW path. The corrected paleopoles allow calculation of new mean Early (~325 Ma) and Late (~312 Ma) Carboniferous inclination-corrected paleopoles for North America, which can be compared to coeval, but uncorrected, paleopoles from Gondwana. Results suggest a Pangea B assemblage unless Gondwanan sedimentary

  9. High field gradient particle accelerator

    DOEpatents

    Nation, J.A.; Greenwald, S.

    1989-05-30

    A high electric field gradient electron accelerator utilizing short duration, microwave radiation, and capable of operating at high field gradients for high energy physics applications or at reduced electric field gradients for high average current intermediate energy accelerator applications is disclosed. Particles are accelerated in a smooth bore, periodic undulating waveguide, wherein the period is so selected that the particles slip an integral number of cycles of the r.f. wave every period of the structure. This phase step of the particles produces substantially continuous acceleration in a traveling wave without transverse magnetic or other guide means for the particle. 10 figs.

  10. High field gradient particle accelerator

    DOEpatents

    Nation, John A.; Greenwald, Shlomo

    1989-01-01

    A high electric field gradient electron accelerator utilizing short duration, microwave radiation, and capable of operating at high field gradients for high energy physics applications or at reduced electric field gradients for high average current intermediate energy accelerator applications. Particles are accelerated in a smooth bore, periodic undulating waveguide, wherein the period is so selected that the particles slip an integral number of cycles of the r.f. wave every period of the structure. This phase step of the particles produces substantially continuous acceleration in a traveling wave without transverse magnetic or other guide means for the particle.

  11. High field electrophoresis—computer simulations

    NASA Astrophysics Data System (ADS)

    Krawczyk, M. J.; Kułakowski, K.

    2004-11-01

    We describe for the first time the results, obtained by means of a new two-dimensional version of a cellular automaton (2DA), designed for the simulation of the gel electrophoresis at high fields. The calculations are performed up to N=442 reptons. The results are compared with those from a modified version of the one-dimensional automaton (1DA), which has been constructed previously. The modification is that the movements of different parts of a molecule of DNA are treated as statistically independent events. This approach is applied also for 2DA. Main results are: (i) for long molecules (N≫1) the velocity v tends to a constant both for 1DA and 2DA; (ii) the diffusion coefficient D for 2DA increases with N; (iii) 2DA enables the formation of so-called hernias, i.e. fragments of DNA locally perpendicular to the molecule, and (iv) a direct observation of the geometration effect. The results (i) and (ii) mimic the experimental behavior at high electric fields. We also calculate a dimensionless quantity y=D/(Lv), where L=Na is the molecule length and a is the stiffness length. The discussion of y reveals the role of the length fluctuations.

  12. HIGH FIELD SOLENOID FOR MUON COOLING.

    SciTech Connect

    KAHN, S.A.; ALSHARO'A, M.; HANLET, P.; JOHNSON, R.P.; KUCHNIR, M.; NEWSHAM, F.; GUPTA, R.C.; PALMER, R.B.; WILLEN, E.

    2006-06-26

    Magnets made with high-temperature superconducting (HTS) coils operating at low temperatures have the potential to produce extremely high fields for use in accelerators and beam lines. The specific application of interest that we are proposing is to use a very high field (of the order of 50 Tesla) solenoid to provide a very small beta region for the final stages of cooling for a muon collider. With the commercial availability of HTS conductor based on BSCCO technology with high current carrying capacity at 4.2 K, very high field solenoid magnets should be possible. In this paper we will evaluate the technical issues associated with building this magnet. In particular we address how to mitigate the high Lorentz stresses associated with this high field magnet.

  13. Space applications of superconductivity - High field magnets

    NASA Technical Reports Server (NTRS)

    Fickett, F. R.

    1979-01-01

    The paper discusses developments in superconducting magnets and their applications in space technology. Superconducting magnets are characterized by high fields (to 15T and higher) and high current densities combined with low mass and small size. The superconducting materials and coil design are being improved and new high-strength composites are being used for magnet structural components. Such problems as maintaining low cooling temperatures (near 4 K) for long periods of time and degradation of existing high-field superconductors at low strain levels can be remedied by research and engineering. Some of the proposed space applications of superconducting magnets include: cosmic ray analysis with magnetic spectrometers, energy storage and conversion, energy generation by magnetohydrodynamic and thermonuclear fusion techniques, and propulsion. Several operational superconducting magnet systems are detailed.

  14. Single-layer high field dipole magnets

    SciTech Connect

    Vadim V. Kashikhin and Alexander V. Zlobin

    2001-07-30

    Fermilab is developing high field dipole magnets for post-LHC hadron colliders. Several designs with a nominal field of 10-12 T, coil bore size of 40-50 mm based on both shell-type and block-type coil geometry are currently under consideration. This paper presents a new approach to magnet design, based on simple and robust single-layer coils optimized for the maximum field, good field quality and minimum number of turns.

  15. Strain sensors for high field pulse magnets

    SciTech Connect

    Martinez, Christian; Zheng, Yan; Easton, Daniel; Farinholt, Kevin M; Park, Gyuhae

    2009-01-01

    In this paper we present an investigation into several strain sensing technologies that are being considered to monitor mechanical deformation within the steel reinforcement shells used in high field pulsed magnets. Such systems generally operate at cryogenic temperatures to mitigate heating issues that are inherent in the coils of nondestructive, high field pulsed magnets. The objective of this preliminary study is to characterize the performance of various strain sensing technologies at liquid nitrogen temperatures (-196 C). Four sensor types are considered in this investigation: fiber Bragg gratings (FBG), resistive foil strain gauges (RFSG), piezoelectric polymers (PVDF), and piezoceramics (PZT). Three operational conditions are considered for each sensor: bond integrity, sensitivity as a function of temperature, and thermal cycling effects. Several experiments were conducted as part of this study, investigating adhesion with various substrate materials (stainless steel, aluminum, and carbon fiber), sensitivity to static (FBG and RFSG) and dynamic (RFSG, PVDF and PZT) load conditions, and sensor diagnostics using PZT sensors. This work has been conducted in collaboration with the National High Magnetic Field Laboratory (NHMFL), and the results of this study will be used to identify the set of sensing technologies that would be best suited for integration within high field pulsed magnets at the NHMFL facility.

  16. Ultra-High-Field MR Neuroimaging

    PubMed Central

    Balchandani, P.; Naidich, T.P.

    2015-01-01

    SUMMARY At ultra-high magnetic fields, such as 7T, MR imaging can noninvasively visualize the brain in unprecedented detail and through enhanced contrast mechanisms. The increased SNR and enhanced contrast available at 7T enable higher resolution anatomic and vascular imaging. Greater spectral separation improves detection and characterization of metabolites in spectroscopic imaging. Enhanced blood oxygen level–dependent contrast affords higher resolution functional MR imaging. Ultra-high-field MR imaging also facilitates imaging of nonproton nuclei such as sodium and phosphorus. These improved imaging methods may be applied to detect subtle anatomic, functional, and metabolic abnormalities associated with a wide range of neurologic disorders, including epilepsy, brain tumors, multiple sclerosis, Alzheimer disease, and psychiatric conditions. At 7T, however, physical and hardware limitations cause conventional MR imaging pulse sequences to generate artifacts, requiring specialized pulse sequences and new hardware solutions to maximize the high-field gain in signal and contrast. Practical considerations for ultra-high-field MR imaging include cost, siting, and patient experience. PMID:25523591

  17. Neurodegenerative disease high-field imaging

    PubMed Central

    van der Grond, J.; van Buchem, M.A.; van Zijl, P.; Webb, A.G.

    2012-01-01

    High field magnetic resonance imaging is showing potential for imaging of neurodegenerative diseases. 7 T MRI is beginning to be used in a clinical research setting and the theoretical benefits, i.e. higher signal-to-noise, sensitivity to iron, improved MRA and increased spectral resolution in spectroscopy are being confirmed. Despite the limited number of studies to date, initial results in patients with multiple sclerosis, Alzheimer’s disease and Huntington’s disease show promising additional features in contrast that may assist in better diagnosis of these disorders. PMID:22548926

  18. Sultan - forced flow, high field test facility

    SciTech Connect

    Horvath, I.; Vecsey, G.; Weymuth, P.; Zellweger, J.

    1981-09-01

    Three European laboratories: CNEN (Frascati, I) ECN (Petten, NL) and SIN (Villigen, CH) decided to coordinate their development efforts and to install a common high field forced flow test facility at Villigen Switzerland. The test facility SULTAN (Supraleiter Testanlage) is presently under construction. As a first step, an 8T/1m bore solenoid with cryogenic periphery will be ready in 1981. The cryogenic system, data acquisition system and power supplies which are contributed by SIN are described. Experimental feasibilities, including cooling, and instrumentation are reviewed. Progress of components and facility construction is described. Planned extension of the background field up to 12T by insert coils is outlined. 5 refs.

  19. Physical processes at high field strengths

    SciTech Connect

    Rhodes, C.K.

    1986-01-01

    Measurements of the radiation produced by the high field interaction with the rare gases have revealed the presence of both copious harmonic production and fluorescence. The highest harmonic observed was the seventeenth (14.6 rm) in Ne, the shortest wavelength ever produced by that means. Strong fluorescence was seen in Ar, Kr, and Xe with the shortest wavelengths observed being below 10 nm. Furthermore, radiation from inner-shell excited configurations in Xe, specifically the 4d/sup 9/5s5p ..-->.. 4d/sup 10/5s manifold at approx. 17.7 nm, was detected. The behaviors of the rare gases with respect to multiquantum ionization, harmonic production, and fluorescence were found to be correlated so that the materials fell into two groups, He and Ne in one and Ar, Kr, and Xe in the other. These experimental findings, in alliance with other studies on inner-shell decay processes, give evidence for a role of atomic correlations in a direct nonlinear process of inner-shell excitation. It is expected that an understanding of these high-field processes will enable the generation of stimulated emission in the x-ray range. 59 refs., 6 figs., 5 tabs.

  20. High-field electron-photon interactions

    SciTech Connect

    Hartemann, F V

    1999-02-26

    Recent advances in novel technologies (including chirped-pulse amplification, femtosecond laser systems operating in the TW-PW range, high-gradient rf photoinjectors, and synchronized relativistic electron bunches with subpicosecond durations and THz bandwidths) allow experimentalists to study the interaction of relativistic electrons with ultrahigh-intensity photon fields. Ponderomotive scattering can accelerate these electrons with extremely high gradients in a three-dimensional vacuum laser focus. The nonlinear Doppler shift induced by relativistic radiation pressure in Compton backscattering is shown to yield complex nonlinear spectra which can be modified by using temporal laser pulse shaping techniques. Colliding laser pulses, where ponderomotive acceleration and Compton backscattering are combined, could also yield extremely short wavelength photons. Finally, one expects strong radiative corrections when the Doppler-upshifted laser wavelength approaches the Compton scale. These are discussed within the context of high-field classical electrodynamics, a new discipline borne out of the aforementioned innovations.

  1. The Pioneer XI high field fluxgate magnetometer

    NASA Technical Reports Server (NTRS)

    Acuna, M. A.; Ness, N. F.

    1975-01-01

    The high field fluxgate magnetometer experiment flown aboard the Pioneer XI spacecraft is described. This extremely simple instrument was used to extend the spacecraft's upper-limit measurement capability by approximately an order of magnitude (from 0.14 mT to 1.00 mT) with minimum power and volume requirements. This magnetometer was designed to complement the low-field measurements provided by a helium vector magnetometer and utilizes magnetic ring core sensors with biaxial orthogonal sense coils. The instrument is a single-range, triaxial-fluxgate magnetometer capable of measuring fields of up to 1 mT along each orthogonal axis, with a maximum resolution of 1 microT.

  2. NSTX High Field Side Gas Fueling System

    SciTech Connect

    H.W. Kugel; M. Anderson; G. Barnes; M. Bell; W. Blanchard; L. Dudek; D. Gates; R. Gernhardt; R. Maingi; D. Mueller; T. Provost; R. Raman; V. Soukhanovskii; J. Winston

    2003-10-09

    Fueling National Spherical Torus Experiment (NSTX) plasmas with gas injected from the high field side (HFS) has produced earlier, more reliable transitions to the H-mode, longer H-mode durations, higher toroidal rotation, and higher edge electron temperature compared with similar discharges using the low field side (LFS) gas fueling injectors. The HFS gas fueling system consists of a Center Stack midplane injector, and an injector at the inner, upper corner of the Center Stack. The challenging design and installation constraints for the HFS gas system involved placing the control components as close as possible to the machine-vacuum interface, devising a special feed-through flange, traversing through vessel regions whose temperatures during bake-out range from 150 to 350 degrees Centigrade, adapting the gas transport tubing size and route to the small instrumentation wire channels behind the existing graphite plasma facing component tiles on the Center Stack, and providing output orifices shielded from excessive plasma power depositions while concentrating the output flow to facilitate fast camera viewing and analysis. Design, recent performance, and future upgrades will be presented.

  3. Structural alloys for high field superconducting magnets

    SciTech Connect

    Morris, J.W. Jr.

    1985-08-01

    Research toward structural alloys for use in high field superconducting magnets is international in scope, and has three principal objectives: the selection or development of suitable structural alloys for the magnet support structure, the identification of mechanical phenomena and failure modes that may influence service behavior, and the design of suitable testing procedures to provide engineering design data. This paper reviews recent progress toward the first two of these objectives. The structural alloy needs depend on the magnet design and superconductor type and differ between magnets that use monolithic and those that employ force-cooled or ICCS conductors. In the former case the central requirement is for high strength, high toughness, weldable alloys that are used in thick sections for the magnet case. In the latter case the need is for high strength, high toughness alloys that are used in thin welded sections for the conductor conduit. There is productive current research on both alloy types. The service behavior of these alloys is influenced by mechanical phenomena that are peculiar to the magnet environment, including cryogenic fatigue, magnetic effects, and cryogenic creep. The design of appropriate mechanical tests is complicated by the need for testing at 4/sup 0/K and by rate effects associated with adiabatic heating during the tests. 46 refs.

  4. High field superconductor development and understanding

    SciTech Connect

    Larbalestier, David C.; Lee, Peter J.; Tarantini, Chiara

    2014-09-28

    All present circular accelerators use superconducting magnets to bend and to focus the particle beams. The most powerful of these machines is the large hadron collider (LHC) at CERN. The main ring dipole magnets of the LHC are made from Nb-Ti but, as the machine is upgraded to higher luminosity, more powerful magnets made of Nb3Sn will be required. Our work addresses how to make the Nb3Sn conductors more effective and more suitable for use in the LHC. The most important property of the superconducting conductor used for an accelerator magnet is that it must have very high critical current density, the property that allows the generation of high magnetic fields in small spaces. Nb3Sn is the original high field superconductor, the material which was discovered in 1960 to allow a high current density in the field of about 9 T. For the high luminosity upgrade of the LHC, much higher current densities in fields of about 12 Tesla will be required. The critical value of the current density is of order 2600 A/mm2 in a field of 12 Tesla. But there are very important secondary factors that complicate the attainment of this critical current density. The first is that the effective filament diameter must be no larger than about 40 µm. The second factor is that 50% of the cross-section of the Nb3Sn conductor that is pure copper must be protected from any poisoning by any Sn leakage through the diffusion barrier that protects the package of niobium and tin from which the Nb3Sn is formed by a high temperature reaction. These three, somewhat conflicting requirements, mean that optimization of the conductor is complex. The work described in this contract report addresses these conflicting requirements. They show that very sophisticated characterizations can uncover the way to satisfy all 3 requirements and they also suggest that the ultimate optimization of Nb3Sn is still not yet in sight

  5. Investigating High Field Gravity using Astrophysical Techniques

    SciTech Connect

    Bloom, Elliott D.; /SLAC

    2008-02-01

    The purpose of these lectures is to introduce particle physicists to astrophysical techniques. These techniques can help us understand certain phenomena important to particle physics that are currently impossible to address using standard particle physics experimental techniques. As the subject matter is vast, compromises are necessary in order to convey the central ideas to the reader. Many general references are included for those who want to learn more. The paragraphs below elaborate on the structure of these lectures. I hope this discussion will clarify my motivation and make the lectures easier to follow. The lectures begin with a brief review of more theoretical ideas. First, elements of general relativity are reviewed, concentrating on those aspects that are needed to understand compact stellar objects (white dwarf stars, neutron stars, and black holes). I then review the equations of state of these objects, concentrating on the simplest standard models from astrophysics. After these mathematical preliminaries, Sec. 2(c) discusses 'The End State of Stars'. Most of this section also uses the simplest standard models. However, as these lectures are for particle physicists, I also discuss some of the more recent approaches to the equation of state of very dense compact objects. These particle-physics-motivated equations of state can dramatically change how we view the formation of black holes. Section 3 focuses on the properties of the objects that we want to characterize and measure. X-ray binary systems and Active Galactic Nuclei (AGN) are stressed because the lectures center on understanding very dense stellar objects, black hole candidates (BHCs), and their accompanying high gravitational fields. The use of x-ray timing and gamma-ray experiments is also introduced in this section. Sections 4 and 5 review information from x-ray and gamma-ray experiments. These sections also discuss the current state of the art in x-ray and gamma-ray satellite experiments and

  6. Recent developments of high field ESR systems in Kobe

    NASA Astrophysics Data System (ADS)

    Ohta, H.; Tomoo, M.; Okubo, S.; Sakurai, T.; Fujisawa, M.; Tomita, T.; Kimata, M.; Yamamoto, T.; Kawauchi, M.; Kindo, K.

    2006-11-01

    The magnetic field of the high field ESR system in Kobe University has been extended to 55 T by using a new non-destructive pulse magnet and the 300 kJ (10kV) capacitor bank. The properties of new 55 T pulse magnet are reported. As an example of its application, the high field ESR measurement of a quantum spin system CsCuCl3 for Hparallela will be shown.

  7. HIGH FIELD Q-SLOPE AND THE BAKING EFFECT

    SciTech Connect

    Ciovati, Gianluigi

    2009-11-01

    The performance of SRF cavities made of bulk Nb at high fields (peak surface magnetic field greater than about 90 mT) is characterized by exponentially increasing RF losses (high-field Q-slope), in the absence of field emission, which are often mitigated by a low temperature (100-140 °C, 12-48h) baking. In this contribution, recent experimental results and phenomenological models to explain this effect will be briefly reviewed. New experimental results on the high-field Q-slope will be presented for cavities that had been heat treated at high temperature in the presence of a small partial pressure of nitrogen. Improvement of the cavity performances have been obtained, while surface analysis measurements on Nb samples treated with the cavities revealed significantly lower hydrogen concentration than for samples that followed standard cavity treatments.

  8. High field CdS detector for infrared radiation

    NASA Technical Reports Server (NTRS)

    Tyagi, R. C.; Robertson, J. B.; Boer, K. W.; Hadley, H. C., Jr. (Inventor)

    1974-01-01

    An infrared radiation detector including a cadmium sulfide platelet having a cathode formed on one of its ends and an anode formed on its other end is presented. The platelet is suitably doped such that stationary high-field domains are formed adjacent the cathode when based in the negative differential conductivity region. A negative potential is applied to the cathode such that a high-field domain is formed adjacent to the cathode. A potential measuring probe is located between the cathode and the anode at the edge of the high-field domain and means are provided for measuring the potential at the probe whereby this measurement is indicative of the infrared radiation striking the platelet.

  9. The high field superconducting magnet program at LLNL: Annual report

    SciTech Connect

    Miller, J.R.; Chaplin, M.R.; Kerns, J.A.; Leber, R.L.; Rosdahl, A.R.; Slack, D.S.; Summers, L.T.; Zbasnik, J.P.

    1986-12-01

    In FY 86 the program continued along several interrelated thrust areas. These thrust areas have been broadly labeled as follows: (1) Superconductor Research and Technology; (2) Magnet Systems Materials Technology; (3) Magnet Systems Design Technology; (4) High Field Test Facility; and (5) Technology Transfer.

  10. Survey of high field superconducting material for accelerator magnets

    SciTech Connect

    Scahlan, R.; Greene, A.F.; Suenaga, M.

    1986-05-01

    The high field superconductors which could be used in accelerator dipole magnets are surveyed, ranking these candidates with respect to ease of fabrication and cost as well as superconducting properties. Emphasis is on Nb/sub 3/Sn and NbTi. 27 refs., 2 figs. (LEW)

  11. High field CdS detector for infrared radiation

    NASA Technical Reports Server (NTRS)

    Tyagi, R. C.; Boer, K. W.; Hadley, H. C.; Robertson, J. B.

    1972-01-01

    New and highly sensitive method of detecting infrared irradiation makes possible solid state infrared detector which is more sensitive near room temperature than usual photoconductive low band gap semiconductor devices. Reconfiguration of high field domains in cadmium sulphide crystals provides basis for discovery.

  12. Developments in materials for high-field magnets

    SciTech Connect

    Sims, J.R.; Hill, M.A.; Walsh, R.P.

    1993-10-01

    Results of the National High Magnetic Field Laboratory`s program of characterization of materials and fabrication techniques used in the construction of high-field pulsed magnets are reported. High-field pulsed magnets require conductors with high mechanical strength (750 MPa or greater YS at 77K) and high electrical conductivity (70% IACS or greater at RT). Electrical insulation and resin systems for vacuum impregnation with high compressive strength (500 MPa at 77K) and moderate thermal conductivity (1kW/mK at 77K) are also required. Developments and future plans for the characterization of new magnet material systems are discussed. Testing result are reported: Mechanical and fatigue testing, electrical conductivity testing and thermal expansion measurements of high strength, high conductivity conductors at cryogenic and room temperature, mechanical testing of a coil support material at cryogenic and room temperature, thermal expansion and thermal conductivity tests of an electrical insulating system at cryogenic temperatures.

  13. High field superconductor development and understanding project, Final Report

    SciTech Connect

    Larbalestier, David C.; Lee, Peter J.

    2009-07-15

    Over 25 years the Applied Superconductivity Center at the University of Wisconsin-Madison provided a vital technical resource to the High Energy Physics community covering development in superconducting strand for HEP accelerator magnet development. In particular the work of the group has been to develop the next generation of high field superconductors for high field application. Grad students Mike Naus, Chad Fischer, Arno Godeke and Matt Jewell improved our understanding of the microstructure and microchemistry of Nb3Sn and their impact on the physical and mechanical properties. The success of this work has led to the continued funding of this work at the ASC after it moved to the NHMFL and also to direct funding from BNL for some aspects of Nb3Sn cable evaluation.

  14. High-field magnetization of Dy2O3

    NASA Technical Reports Server (NTRS)

    Flood, D. J.

    1974-01-01

    The magnetization of powdered samples of Dy2O3 has been measured at temperatures between 1.45 deg and 4.2 K, in applied magnetic fields ranging to 7 Teslas. A linear dependence of magnetization on applied field is observable in high field region, the slope of which is independent of temperature over the range investigated. The extrapolated saturation magnetic moment is 2.77 + or - 0.08 Bohr magnetons per ion.

  15. High-field magnetization of Dy2O3

    NASA Technical Reports Server (NTRS)

    Flood, D. J.

    1974-01-01

    The magnetization of powdered samples of Dy2O3 has been measured at temperatures between 1.45 and 4.2 K, in applied magnetic fields ranging to 70 kilogauss. A linear dependence of magnetization on applied field is observable in the high-field region, the slope of which is independent of temperature over the range investigated. The extrapolated saturation magnetic moment is about 2.77 Bohr magnetons per ion.

  16. Superconducting Nb3Ge for high-field magnets

    NASA Technical Reports Server (NTRS)

    Braginski, A. I.; Daniel, M. R.; Roland, C. W.; Woollam, J. A.

    1978-01-01

    Superconducting Nb3Ge tape conductors 5 to 10 m long were fabricated by chemical vapor deposition. Such tapes could be used in high-field magnet applications. Average tape properties set the upper performance limit of a magnet at 17 teslas (4.2 K). Highest critical-current densities obtained in thin and layered films set the upper performance limit at 20 teslas (4.2 K).

  17. High field optical nonlinearity and the Kramers-Kronig relations.

    PubMed

    Wahlstrand, J K; Cheng, Y-H; Milchberg, H M

    2012-09-14

    The nonlinear optical response to high fields is absolutely measured for the noble gas atoms He, Ne, Ar, Kr, and Xe. We find that the response is quadratic in the laser field magnitude up to the ionization threshold of each gas. Its size and quadratic dependence are well predicted by a Kramers-Kronig analysis employing known ionization probabilities, and the results are consistent with calculations using the time-dependent Schrödinger equation.

  18. High-field Magnet Development toward the High Luminosity LHC

    SciTech Connect

    Apollinari, Giorgio

    2014-07-01

    The upcoming Luminosity upgrade of the LHC (HL-LHC) will rely on the use of Accelerator Quality Nb3Sn Magnets which have been the focus of an intense R&D effort in the last decade. This contribution will describe the R&D and results of Nb3Sn Accelerator Quality High Field Magnets development efforts, with emphasis on the activities considered for the HL-LHC upgrades.

  19. Homogenous BSCCO-2212 Round Wires for Very High Field Magnets

    SciTech Connect

    Dr. Scott Campbell Dr. Terry Holesinger Dr. Ybing Huang

    2012-06-30

    The performance demands on modern particle accelerators generate a relentless push towards higher field magnets. In turn, advanced high field magnet development places increased demands on superconducting materials. Nb3Sn conductors have been used to achieve 16 T in a prototype dipole magnet and are thought to have the capability for {approx}18 T for accelerator magnets (primarily dipoles but also higher order multipole magnets). However there have been suggestions and proposals for such magnets higher than 20 T. The High Energy Physics Community (HEP) has identified important new physics opportunities that are enabled by extremely high field magnets: 20 to 50 T solenoids for muon cooling in a muon collider (impact: understanding of neutrinos and dark matter); and 20+ T dipoles and quadrupoles for high energy hadron colliders (impact: discovery reach far beyond present). This proposal addresses the latest SBIR solicitation that calls for grant applications that seek to develop new or improved superconducting wire technologies for magnets that operate at a minimum of 12 Tesla (T) field, with increases up to 15 to 20 T sought in the near future (three to five years). The long-term development of accelerator magnets with fields greater than 20 T will require superconducting wires having significantly better high-field properties than those possessed by current Nb{sub 3}Sn or other A15 based wires. Given the existing materials science base for Bi-2212 wire processing, we believe that Bi{sub 2}Sr{sub 2}CaCu{sub 2}O{sub y} (Bi-2212) round wires can be produced in km-long piece lengths with properties suitable to meet both the near term and long term needs of the HEP community. The key advance will be the translation of this materials science base into a robust, high-yield wire technology. While the processing and application of A15 materials have advanced to a much higher level than those of the copper oxide-based, high T{sub c} (HTS) counterparts, the HTS materials have

  20. T1 and susceptibility contrast at high fields

    NASA Astrophysics Data System (ADS)

    Neelavalli, Jaladhar

    Clinical imaging at high magnetic field strengths (≥ 3Tesla) is sought after primarily due to the increased signal strength available at these fields. This increased SNR can be used to perform: (a) high resolution imaging in the same time as at lower field strengths; (b) the same resolution imaging with much faster acquisition; and (c) functional MR imaging (fMRI), dynamic perfusion and diffusion imaging with increased sensitivity. However they are also associated with increased power deposition (SAR) due to increase in imaging frequency and longer T1 relaxation times. Longer T1s mean longer imaging times for generating good T1 contrast images. On the other hand for faster imaging, at high fields fast spin echo or magnetization prepared sequences are conventionally proposed which are, however, associated with high SAR values. Imaging with low SAR is more and more important as we move towards high fields and particularly for patients with metallic implants like pacemakers or deep brain stimulator. The SAR limit acceptable for these patients is much less than the limit acceptable for normal subjects. A new method is proposed for imaging at high fields with good contrast with simultaneous reduction in power deposition. Further, T1 based contrast optimization problem in FLASH imaging is considered for tissues with different T1s but same spin densities. The solution providing optimal imaging parameters is simplified for quick and easy computation in a clinical setting. The efficacy of the simplification is evaluated and practical limits under which the simplification can be applied are worked out. The phase difference due to variation in magnetic susceptibility property among biological tissues is another unique source of contrast which is different from the conventional T1, T2 and T2* contrast. This susceptibility based phase contrast has become more and more important at high fields, partly due to contrast generation issues due to longer T 1s and shorter T2s and

  1. High Field Magnet R&D in the USA

    SciTech Connect

    Gourlay, Stephen A.

    2003-06-24

    Accelerator magnet technology is currently dominated by the use of NbTi superconductor. New and more demanding applications for superconducting accelerator magnets require the use of alternative materials. Several programs in the US are taking advantage of recent improvements in Nb{sub 3}Sn to develop high field magnets for new applications. Highlights and challenges of the US R&D program are presented along with the status of conductor development. In addition, a new R&D focus, the US LHC Accelerator Research Program, will be discussed.

  2. High-field small animal magnetic resonance oncology studies

    NASA Astrophysics Data System (ADS)

    Bokacheva, Louisa; Ackerstaff, Ellen; LeKaye, H. Carl; Zakian, Kristen; Koutcher, Jason A.

    2014-01-01

    This review focuses on the applications of high magnetic field magnetic resonance imaging (MRI) and spectroscopy (MRS) to cancer studies in small animals. High-field MRI can provide information about tumor physiology, the microenvironment, metabolism, vascularity and cellularity. Such studies are invaluable for understanding tumor growth and proliferation, response to treatment and drug development. The MR techniques reviewed here include 1H, 31P, chemical exchange saturation transfer imaging and hyperpolarized 13C MRS as well as diffusion-weighted, blood oxygen level dependent contrast imaging and dynamic contrast-enhanced MRI. These methods have been proven effective in animal studies and are highly relevant to human clinical studies.

  3. The Mechanical Design Optimization of a High Field HTS Solenoid

    SciTech Connect

    Lalitha, SL; Gupta, RC

    2015-06-01

    This paper describes the conceptual design optimization of a large aperture, high field (24 T at 4 K) solenoid for a 1.7 MJ superconducting magnetic energy storage device. The magnet is designed to be built entirely of second generation (2G) high temperature superconductor tape with excellent electrical and mechanical properties at the cryogenic temperatures. The critical parameters that govern the magnet performance are examined in detail through a multiphysics approach using ANSYS software. The analysis results formed the basis for the performance specification as well as the construction of the magnet.

  4. Understanding and manipulating the RF fields at high field MRI.

    PubMed

    Ibrahim, Tamer S; Hue, Yik-Kiong; Tang, Lin

    2009-11-01

    This paper presents a complete overview of the electromagnetics (radiofrequency aspect) of MRI at low and high fields. Using analytical formulations, numerical modeling (computational electromagnetics), and ultrahigh field imaging experiments, the physics that impacts the electromagnetic quantities associated with MRI, namely (1) the transmit field, (2) receive field, and (3) total electromagnetic power absorption, is analyzed. The physical interpretation of the above-mentioned quantities is investigated by electromagnetic theory, to understand 'What happens, in terms of electromagnetics, when operating at different static field strengths?' Using experimental studies and numerical simulations, this paper also examines the physical and technological feasibilities by which all or any of these specified electromagnetic quantities can be manipulated through techniques such as B(1) shimming (phased array excitation) and signal combination using a receive array in order to advance MRI at high field strengths. Pertinent to this subject and with highly coupled coils operating at 7 T, this paper also presents the first phantom work on B(1) shimming without B(1) measurements.

  5. Detecting breast microcalcifications with high-field MRI.

    PubMed

    de Leeuw, Hendrik; Stehouwer, Bertine L; Bakker, Chris J G; Klomp, Dennis W J; van Diest, Paul J; Luijten, Peter R; Seevinck, Peter R; van den Bosch, Maurice A A J; Viergever, Max A; Veldhuis, Wouter B

    2014-05-01

    The aim of this study was to detect microcalcifications in human whole breast specimens using high-field MRI. Four mastectomy specimens, obtained with approval of the institutional review board, were subjected to gradient-echo MRI acquisitions on a high-field MR scanner. The phase derivative was used to detect microcalcifications. The echo time and imaging resolution were varied to study the sensitivity of the proposed method. Computed tomography images of the mastectomy specimens and prior acquired mammography images were used to validate the results. A template matching algorithm was designed to detect microcalcifications automatically. The three spatial derivatives of the signal phase surrounding a field-perturbing object allowed three-dimensional localization, as well as the discrimination of diamagnetic field-perturbing objects, such as calcifications, and paramagnetic field-perturbing structures, e.g. blood. A longer echo time enabled smaller disturbances to be detected, but also resulted in shading as a result of other field-disturbing materials. A higher imaging resolution increased the detection sensitivity. Microcalcifications in a linear branching configuration that spanned over 8 mm in length were detected. After manual correction, the automatic detection tool identified up to 18 microcalcifications within the samples, which was in close agreement with the number of microcalcifications found on previously acquired in vivo mammography images. Microcalcifications can be detected by MRI in human whole breast specimens by the application of phase derivative imaging. PMID:24535752

  6. High field - low energy muon ionization cooling channel

    NASA Astrophysics Data System (ADS)

    Kamal Sayed, Hisham; Palmer, Robert B.; Neuffer, David

    2015-09-01

    Muon beams are generated with large transverse and longitudinal emittances. In order to achieve the low emittances required by a muon collider, within the short lifetime of the muons, ionization cooling is required. Cooling schemes have been developed to reduce the muon beam 6D emittances to ≈300 μ m -rad in transverse and ≈1 - 1.5 mm in longitudinal dimensions. The transverse emittance has to be further reduced to ≈50 - 25 μ m -rad with an upper limit on the longitudinal emittance of ≈76 mm in order to meet the high-energy muon collider luminosity requirements. Earlier studies of the transverse cooling of low energy muon beams in high field magnets showed a promising performance, but did not include transverse or longitudinal matching between the stages. In this study we present the first complete design of the high field-low energy ionization cooling channel with transverse and longitudinal matching. The channel design was based on strong focusing solenoids with fields of 25-30 T and low momentum muon beam starting at 135 MeV /c and gradually decreasing. The cooling channel design presented here is the first to reach ≈50 micron scale emittance beam. We present the channel's optimized design parameters including the focusing solenoid fields, absorber parameters and the transverse and longitudinal matching.

  7. Volcanic sanidinites: an example for the mobilization of high field strength elements (HFSE) in magmatic systems

    NASA Astrophysics Data System (ADS)

    Aßbichler, Donjá; Heuss-Aßbichler, Soraya; Müller, Dirk; Kunzmann, Thomas

    2016-04-01

    In earth science the mobility of high field strength elements (HFSE) is generally discussed in context of hydrothermal processes. Recent investigations mainly address processes in (late) magmatic-, metamorphic- and submarine hydrothermal systems. They have all in common that H2O is main solvent. The transport of HFSE is suggested to be favored by volatiles, like boron, fluorine, phosphate and sulfate (Jiang et al., 2005). In this study processes in magmatic system are investigated. Sanidinites are rare rocks of igneous origin and are found as volcanic ejecta of explosive volcanoes. They consist mainly of sanidine and minerals of the sodalite group. The very porous fabric of these rocks is an indication of their aggregation from a gaseous magmatic phase. The large sanidine crystals (up to several centimeters) are mostly interlocking, creating large cavities between some crystals. In these pores Zr crystallizes as oxide (baddeleyite, ZrO2) or silicate (zircon, ZrSiO4). The euhedral shape of these minerals is a further indication of their formation out of the gas phase. Furthermore, bubbles in glass observed in some samples are evidence for gas-rich reaction conditions during the formation of the sanidinites. The formation of sanidinites is suggested to be an example for solvothermal processes in natural systems. Solvothermal processes imply the solvation, transport and recrystallization of elements in a gas phase. Results obtained from whole rock analysis from sanidinites from Laacher See (Germany) show a positive correlation between LOI, sulfate, Cl, and Na with the HFSE like Zr. Na-rich conditions seem to ameliorate the solvothermal transport of Zr. All these features point to the formation of sanidinites in the upper part of a magma chamber, where fluid consisting of SO3 and Cl compounds in addition to H2O, CO2 and HFSE (high field strength elements) like Zr accumulate.

  8. High-Gain High-Field Fusion Plasma.

    PubMed

    Li, Ge

    2015-01-01

    A Faraday wheel (FW)-an electric generator of constant electrical polarity that produces huge currents-could be implemented in an existing tokamak to study high-gain high-field (HGHF) fusion plasma, such as the Experimental Advanced Superconducting Tokamak (EAST). HGHF plasma can be realized in EAST by updating its pulsed-power system to compress plasma in two steps by induction fields; high gains of the Lawson trinity parameter and fusion power are both predicted by formulating the HGHF plasma. Both gain rates are faster than the decrease rate of the plasma volume. The formulation is checked by earlier ATC tests. Good agreement between theory and tests indicates that scaling to over 10 T at EAST may be possible by two-step compressions with a compression ratio of the minor radius of up to 3. These results point to a quick new path of fusion plasma study, i.e., simulating the Sun by EAST. PMID:26507314

  9. Bi-2212 round wire development for high field applications

    NASA Astrophysics Data System (ADS)

    Miao, H.; Huang, Y.; Hong, S.; Gerace, M.; Parrell, J.

    2014-05-01

    Oxford Superconducting Technology (OST) has been continuously improving Bi-2212 round wire performance because of its potential for application in high-field magnets (> 25 T). We focused on Bi-2212 wire configuration design, filament densification and reducing carbon and hydrogen contamination to improve the engineering critical current density (JE). Several wire configurations have been developed to meet different wire diameter and operating current requirements. The swaging, cold isostatic pressing (CIP) and over-pressure heat treatment processes have been demonstrated to effectively increase Bi-2212 filament mass density in the final wire and result in high performance over long length. The JE values exceeding 550 A/mm2 at 4.2 K, 15 T have been achieved on the CIPed 1 m long sample using a 10 bar over-pressure (OP) heat treatment. The twisted Bi-2212 wire significantly reduced ac loss without the critical current degradation.

  10. SKEW QUADRUPOLES IN RHIC DIPOLE MAGNETS AT HIGH FIELDS.

    SciTech Connect

    JAIN, A.; GUPTA, P.; THOMPSON, P.; WANDERER, P.

    1995-06-11

    In the RHIC arc dipoles, the center of the cold mass lies above the center of the cryostat. At the maximum design field, the magnetic flux lines leak through the yoke to the asymmetrically located cryostat, which provides an additional return path. This introduces a systematic top-bottom asymmetry leading to a skew quadrupole term at high fields. A similar asymmetry is also created by any difference in weights of the upper and the lower yoke halves. Data from measurements of several RHIC dipoles are presented to study this effect. In the current production series of the RDIC dipoles, an attempt is made to compensate the effect of the cryostat by an asymmetry in the iron yoke. Seven dipoles with this type of yoke have been cold tested, and show a reduced saturation in the skew quadrupole term, as expected.

  11. Improved capacitive stress transducers for high-field superconducting magnets

    NASA Astrophysics Data System (ADS)

    Benson, Christopher Pete; Holik, Eddie Frank, III; Jaisle, Andrew; McInturff, A.; McIntyre, P.

    2012-06-01

    High-field (12-18 Tesla) superconducting magnets are required to enable an increase in the energy of future colliders. Such field strength requires the use of Nb3Sn superconductor, which has limited tolerance for compressive and shear strain. A strategy for stress management has been developed at Texas A&M University and is being implemented in TAMU3, a short-model 14 Tesla stress-managed Nb3Sn block dipole. The strategy includes the use of laminar capacitive stress transducers to monitor the stresses within the coil package. We have developed fabrication techniques and fixtures, which improve the reproducibility of the transducer response both at room temperature and during cryogenic operation. This is a report of the status of transducer development.

  12. REVIEW OF HIGH FIELD Q SLOPE, CAVITY MEASUREMENTS

    SciTech Connect

    Gianluigi Ciovati

    2008-01-23

    One of the most interesting phenomenon occurring in superconducting radio-frequency (SRF) cavities made of bulk niobium is represented by a sharp decrease of the quality factor above peak surface magnetic field of about 90 mT and is referred to as "high field Q-slope" or "Q-drop". This phenomenon was observed first in 1997 and since then some effort was devoted to the understanding of the causes behind it. Still, no clear physical interpretation of the Q-drop has emerged, despite several attempts. In this contribution, I will review the experimental results for various cavities measured in many laboratories and I will try to identify common features and differences related to the Q-drop.

  13. High-Gain High-Field Fusion Plasma

    NASA Astrophysics Data System (ADS)

    Li, Ge

    2015-10-01

    A Faraday wheel (FW)—an electric generator of constant electrical polarity that produces huge currents—could be implemented in an existing tokamak to study high-gain high-field (HGHF) fusion plasma, such as the Experimental Advanced Superconducting Tokamak (EAST). HGHF plasma can be realized in EAST by updating its pulsed-power system to compress plasma in two steps by induction fields; high gains of the Lawson trinity parameter and fusion power are both predicted by formulating the HGHF plasma. Both gain rates are faster than the decrease rate of the plasma volume. The formulation is checked by earlier ATC tests. Good agreement between theory and tests indicates that scaling to over 10 T at EAST may be possible by two-step compressions with a compression ratio of the minor radius of up to 3. These results point to a quick new path of fusion plasma study, i.e., simulating the Sun by EAST.

  14. High Field Small Animal Magnetic Resonance Oncology Studies

    PubMed Central

    Bokacheva, Louisa; Ackerstaff, Ellen; LeKaye, H. Carl; Zakian, Kristen; Koutcher, Jason A.

    2014-01-01

    This review focuses on the applications of high magnetic field magnetic resonance imaging (MRI) and spectroscopy (MRS) to cancer studies in small animals. High field MRI can provide information about tumor physiology, the microenvironment, metabolism, vascularity and cellularity. Such studies are invaluable for understanding tumor growth and proliferation, response to treatment and drug development. The MR techniques reviewed here include 1H, 31P, Chemical Exchange Saturation Transfer (CEST) imaging, and hyperpolarized 13C MR spectroscopy as well as diffusion-weighted, Blood Oxygen Level Dependent (BOLD) contrast imaging, and dynamic contrast-enhanced MR imaging. These methods have been proven effective in animal studies and are highly relevant to human clinical studies. PMID:24374985

  15. Voltage spike detection in high field superconducting accelerator magnets

    SciTech Connect

    Orris, D.F.; Carcagno, R.; Feher, S.; Makulski, A.; Pischalnikov, Y.M.; /Fermilab

    2004-12-01

    A measurement system for the detection of small magnetic flux changes in superconducting magnets, which are due to either mechanical motion of the conductor or flux jump, has been developed at Fermilab. These flux changes are detected as small amplitude, short duration voltage spikes, which are {approx}15mV in magnitude and lasts for {approx}30 {micro}sec. The detection system combines an analog circuit for the signal conditioning of two coil segments and a fast data acquisition system for digitizing the results, performing threshold detection, and storing the resultant data. The design of the spike detection system along with the modeling results and noise analysis will be presented. Data from tests of high field Nb{sub 3}Sn magnets at currents up to {approx}20KA will also be shown.

  16. Spontaneous Radiation Emission from Short, High Field Strength Insertion Devices

    SciTech Connect

    Geoffrey Krafft

    2005-09-15

    Since the earliest papers on undulaters were published, it has been known how to calculate the spontaneous emission spectrum from ''short'' undulaters when the magnetic field strength parameter is small compared to unity, or in ''single'' frequency sinusoidal undulaters where the magnetic field strength parameter is comparable to or larger than unity, but where the magnetic field amplitude is constant throughout the undulater. Fewer general results have been obtained in the case where the insertion device is both short, i.e., the magnetic field strength parameter changes appreciably throughout the insertion device, and the magnetic field strength is high enough that ponderomotive effects, radiation retardation, and harmonic generation are important physical phenomena. In this paper a general method is presented for calculating the radiation spectrum for short, high-field insertion devices. It is used to calculate the emission from some insertion device designs of recent interest.

  17. Topical Developments in High-Field Dynamic Nuclear Polarization

    PubMed Central

    Kiesewetter, Matthew K.; Frantz, Derik K.; Walish, Joseph J.; Ravera, Enrico; Luchinat, Claudio; Swager, Timothy M.; Griffin, Robert G.

    2015-01-01

    We report our recent efforts directed at improving high-field DNP experiments. We investigated a series of thiourea nitroxide radicals and the associated DNP enhancements ranging from ε = 25 to 82 that demonstrate the impact of molecular structure on performance. We directly polarized low-gamma nuclei including 13C, 2H, and 17O using trityl via the cross effect. We discuss a variety of sample preparation techniques for DNP with emphasis on the benefit of methods that do not use a glass-forming cryoprotecting matrix. Lastly, we describe a corrugated waveguide for use in a 700 MHz / 460 GHz DNP system that improves microwave delivery and increases enhancements up to 50%. PMID:25977588

  18. Stepped Impedance Resonators for High Field Magnetic Resonance Imaging

    PubMed Central

    Akgun, Can E.; DelaBarre, Lance; Yoo, Hyoungsuk; Sohn, Sung-Min; Snyder, Carl J.; Adriany, Gregor; Ugurbil, Kamil; Gopinath, Anand; Vaughan, J. Thomas

    2014-01-01

    Multi-element volume radio-frequency (RF) coils are an integral aspect of the growing field of high field magnetic resonance imaging (MRI). In these systems, a popular volume coil of choice has become the transverse electromagnetic (TEM) multi-element transceiver coil consisting of microstrip resonators. In this paper, to further advance this design approach, a new microstrip resonator strategy in which the transmission line is segmented into alternating impedance sections referred to as stepped impedance resonators (SIRs) is investigated. Single element simulation results in free space and in a phantom at 7 tesla (298 MHz) demonstrate the rationale and feasibility of the SIR design strategy. Simulation and image results at 7 tesla in a phantom and human head illustrate the improvements in transmit magnetic field, as well as, RF efficiency (transmit magnetic field versus SAR) when two different SIR designs are incorporated in 8-element volume coil configurations and compared to a volume coil consisting of microstrip elements. PMID:23508243

  19. High-field transport in two-dimensional graphene

    NASA Astrophysics Data System (ADS)

    Fang, Tian; Konar, Aniruddha; Xing, Huili; Jena, Debdeep

    2011-09-01

    Transport of carriers in two-dimensional graphene at high electric fields is investigated by combining semianalytical and Monte Carlo methods. A semianalytical high-field transport model based on the high rate of optical phonon emission provides useful estimates of the saturation currents in graphene. For developing a more accurate picture, the nonequilibrium (hot) phonon effect and the role of electron-electron scattering were studied using Monte Carlo simulations. Monte Carlo simulations indicate that the hot phonon effect plays a dominant role in current saturation, and electron-electron scattering strongly thermalizes the hot carrier population in graphene. We also find that electron-electron scattering removes negative differential resistance in graphene. Transient phenomenon such as velocity overshoot can be used to speed up graphene-based high-speed electronic devices by shrinking the channel length below 80 nm if electrostatic control can be exercised in the absence of a band gap.

  20. Rapid brain MRI acquisition techniques at ultra-high fields.

    PubMed

    Setsompop, Kawin; Feinberg, David A; Polimeni, Jonathan R

    2016-09-01

    Ultra-high-field MRI provides large increases in signal-to-noise ratio (SNR) as well as enhancement of several contrast mechanisms in both structural and functional imaging. Combined, these gains result in a substantial boost in contrast-to-noise ratio that can be exploited for higher-spatial-resolution imaging to extract finer-scale information about the brain. With increased spatial resolution, however, there is a concurrent increased image-encoding burden that can cause unacceptably long scan times for structural imaging and slow temporal sampling of the hemodynamic response in functional MRI - particularly when whole-brain imaging is desired. To address this issue, new directions of imaging technology development - such as the move from conventional 2D slice-by-slice imaging to more efficient simultaneous multislice (SMS) or multiband imaging (which can be viewed as "pseudo-3D" encoding) as well as full 3D imaging - have provided dramatic improvements in acquisition speed. Such imaging paradigms provide higher SNR efficiency as well as improved encoding efficiency. Moreover, SMS and 3D imaging can make better use of coil sensitivity information in multichannel receiver arrays used for parallel imaging acquisitions through controlled aliasing in multiple spatial directions. This has enabled unprecedented acceleration factors of an order of magnitude or higher in these imaging acquisition schemes, with low image artifact levels and high SNR. Here we review the latest developments of SMS and 3D imaging methods and related technologies at ultra-high field for rapid high-resolution functional and structural imaging of the brain. Copyright © 2016 John Wiley & Sons, Ltd.

  1. Alternative Contrast Mechanisms in High Field MR Microscopy.

    NASA Astrophysics Data System (ADS)

    Engelhardt, Robert Thomas

    1995-01-01

    In high-field MR Microscopy, the T_1 relaxation times may become long and converge while the T_2 relaxation times may become short and converge. As a result, much of the contrast is due solely to differences in spin density. The use of T_{1rho} as an alternative contrast parameter in high-field MR Microscopy has been explored here. To this end, MR Microscopy experiments have been performed using 2.0 and 9.4 Tesla Bruker MRI systems. Spectroscopy experiments at 9.4 Tesla were performed on several phantoms (5.75% agar gel, 1.0 mM MnCl_2, 7.3% and 20% gelatin). Imaging experiments were performed on two, 17.5 day old, perfusion fixed, mouse embryos, embedded in 7.3% gelatin to minimize drying and susceptibility differences. The relaxation times, T_1, T _2, and T_{1rho }, the signal to noise ratios (SNR) and contrast to noise ratios (CNR), have been measured for several types of tissue. The T_{1rho} relaxation times were measured at four locking field strengths, 0.7, 0.9, 1.3 and 1.7 G. T_1 and T_2 imaging experiments were performed using a conventional spin warp imaging sequence. T_{1rho } imaging experiments were performed using a presaturating spin locking pulse, followed by a conventional spin warp imaging sequence. Muscle, diencephalon, lung and liver were chosen for the relaxation time measurements as they offered both good tissue specificity and size. Both static and locking field dispersion of T _{1rho} were observed in the selected mouse embryo tissues. The observed T _{1rho} relaxation times were generally longer than the T_2 relaxation times, increased with locking field strength, and were consistently shorter at 9.4 Tesla than at 2.0 Tesla. The static field dispersion of T_ {1rho} and T_2 are both believed to be due, in part, to diffusion losses through susceptibility induced gradients. The losses are much smaller in the T_{1rho} images, and decrease as the locking pulse is increased. Finally, under certain circumstances, T_{1rho }-weighting could produce

  2. Applications of high dielectric materials in high field magnetic resonance

    NASA Astrophysics Data System (ADS)

    Haines, Kristina Noel

    At high magnetic fields, radiation losses, wavelength effects, self-resonance, and the high resistance of components all contribute to losses in conventional RF MRI coil designs. The hypothesis tested here is that these problems can be combated by the use of high permittivity ceramic materials at high fields. High permittivity ceramic dielectric resonators create strong uniform magnetic fields in compact structures at high frequencies and can potentially solve some of the challenges of high field coil design. In this study NMR probes were constructed for operation at 600 MHz (14.1 Tesla) and 900 MHz (21.1 Tesla) using inductively fed CaTiO3 (relative permittivity of 156-166) cylindrical hollow bore dielectric resonators. The designs showed the electric field is largely confined to the dielectric itself, with near zero values in the hollow bore, which accommodates the sample. The 600 MHz probe has an unmatched Q value greater than 2000. Experimental and simulation mapping of the RF field show good agreement, with the ceramic resonator giving a pulse width approximately 25% less than a loop gap resonator of similar inner dimensions. High resolution images, with voxel dimensions less than 50 microm3, have been acquired from fixed zebrafish samples, showing excellent delineation of several fine structures. The 900 MHz probe has an unmatched Q value of 940 and shows Q performance five times better than Alderman-Grant and loop-gap resonators of similar dimensions. High resolution images were acquired of an excised mouse spinal cord (25 microm 3) and an excised rat soleus muscle (20 microm3). The spatial distribution of electromagnetic fields within the human body can be tailored using external dielectric materials. Here, a new material is introduced with high dielectric constant and low background MRI signal. The material is based upon metal titanates, which can be made into geometrically formable suspensions in de-ionized water. The suspension's material properties are

  3. High-Field Transport in Semiconducting Material and Devices.

    NASA Astrophysics Data System (ADS)

    Ahmad, Nisar

    1990-01-01

    Available from UMI in association with The British Library. Considering the developments and most recent technological innovations of semiconductor devices, it is important to investigate the ramifications of charge carrier transport in high electric field in modern semiconductor microstructures, where the electric fields are found to be necessarily high. The fundamental ideas of transport theory including the mobility -limiting scattering mechanisms are reviewed. The ideas of linear transport are extended and the derivation of the high-field distribution is described in a single-valley model appropriate for the band structures of silicon and germanium. The velocity-field profile obtained from this distribution function is compared with the experimental results on bulk (3-dimensional) samples of silicon and germanium. The two-band model of intrinsic transport in a high electric field is also included. The single valley distribution is applied to the multi-valley structures of CaAs and (InGa)As to explain the experimentally observed negative differential resistivity in bulk samples. The calculations are further extended to two dimensional quantum -well microstructures of GaAs and (InGa)As. The conditions necessary for negative differential resistivity in these microstructures to be observable is also discussed. The applications of the above ideas in modelling submicron -length channel field effect transistors (MOSFET's and MODFET's) is discussed. Suggestions for further future applications of the analysis are offered.

  4. Graded High Field Nb3Sn Dipole Magnets

    SciTech Connect

    Caspi, S.; Ferracin, P.; Gourlay, S.

    2007-06-01

    Dipole magnets with fields beyond 16T will require superconducting coils that are at least 40 mm thick, an applied pres-stress around 150 MPa and a protection scheme for stored energy in the range of 1-2 MJ/m. The coil size will have a direct impact on the overall magnet cost and the stored energy will raise new questions on protection. To reduce coil size and minimize risk, the coil may have to be graded. Grading is achieved by splitting the coil into several layers with current densities that match the short sample field in each layer. Grading, especially at high fields, can be effective; however it will also significantly raise the stress. In this paper we report on the results of a study on the coil size and field relation to that of the stress and stored energy. We then extend the results to graded coils and attempt to address high stress issues and ways to reduce it.

  5. High-Gain High-Field Fusion Plasma

    PubMed Central

    Li, Ge

    2015-01-01

    A Faraday wheel (FW)—an electric generator of constant electrical polarity that produces huge currents—could be implemented in an existing tokamak to study high-gain high-field (HGHF) fusion plasma, such as the Experimental Advanced Superconducting Tokamak (EAST). HGHF plasma can be realized in EAST by updating its pulsed-power system to compress plasma in two steps by induction fields; high gains of the Lawson trinity parameter and fusion power are both predicted by formulating the HGHF plasma. Both gain rates are faster than the decrease rate of the plasma volume. The formulation is checked by earlier ATC tests. Good agreement between theory and tests indicates that scaling to over 10 T at EAST may be possible by two-step compressions with a compression ratio of the minor radius of up to 3. These results point to a quick new path of fusion plasma study, i.e., simulating the Sun by EAST. PMID:26507314

  6. Diffuse Axonal Injury at Ultra-High Field MRI

    PubMed Central

    Moenninghoff, Christoph; Kraff, Oliver; Maderwald, Stefan; Umutlu, Lale; Theysohn, Jens M.; Ringelstein, Adrian; Wrede, Karsten H.; Deuschl, Cornelius; Altmeppen, Jan; Ladd, Mark E.; Forsting, Michael; Quick, Harald H.; Schlamann, Marc

    2015-01-01

    Objective Diffuse axonal injury (DAI) is a specific type of traumatic brain injury caused by shearing forces leading to widespread tearing of axons and small vessels. Traumatic microbleeds (TMBs) are regarded as a radiological marker for DAI. This study aims to compare DAI-associated TMBs at 3 Tesla (T) and 7 T susceptibility weighted imaging (SWI) to evaluate possible diagnostic benefits of ultra-high field (UHF) MRI. Material and Methods 10 study participants (4 male, 6 female, age range 20-74 years) with known DAI were included. All MR exams were performed with a 3 T MR system (Magnetom Skyra) and a 7 T MR research system (Magnetom 7 T, Siemens AG, Healthcare Sector, Erlangen, Germany) each in combination with a 32-channel-receive coil. The average time interval between trauma and imaging was 22 months. Location and count of TMBs were independently evaluated by two neuroradiologists on 3 T and 7 T SWI images with similar and additionally increased spatial resolution at 7 T. Inter- and intraobserver reliability was assessed using the interclass correlation coefficient (ICC). Count and diameter of TMB were evaluated with Wilcoxon signed rank test. Results Susceptibility weighted imaging revealed a total of 485 TMBs (range 1-190, median 25) at 3 T, 584 TMBs (plus 20%, range 1-262, median 30.5) at 7 T with similar spatial resolution, and 684 TMBs (plus 41%, range 1-288, median 39.5) at 7 T with 10-times higher spatial resolution. Hemorrhagic DAI appeared significantly larger at 7 T compared to 3 T (p = 0.005). Inter- and intraobserver correlation regarding the counted TMB was high and almost equal 3 T and 7 T. Conclusion 7 T SWI improves the depiction of small hemorrhagic DAI compared to 3 T and may be supplementary to lower field strengths for diagnostic in inconclusive or medicolegal cases. PMID:25793614

  7. Ultra-high field magnets for whole-body MRI

    NASA Astrophysics Data System (ADS)

    Warner, Rory

    2016-09-01

    For whole-body MRI, an ultra-high field (UHF) magnet is currently defined as a system operating at 7 T or above. Over 70 UHF magnets have been built, all with the same technical approach originally developed by Magnex Scientific Ltd. The preferred coil configuration is a compensated solenoid. In this case, the majority of the field is generated by a simple long solenoid that stretches the entire length of the magnet. Additional coils are wound on a separate former outside the main windings with the purpose of balancing the homogeneity. Most of the magnets currently in operation are passively shielded systems where the magnet is surrounded by a steel box of 200–870 tonnes of carbon steel. More recently actively shielded magnets have been built for operation at 7 T; in this case the stray field is controlled by with reverse turns wound on a separate former outside the primary coils. Protection against quench damage is much more complex with an actively shielded magnet design due to the requirement to prevent the stray field from increasing during a quench. In the case of the 7 T 900 magnet this controlled by combining some of the screening coils into each section of the protection circuit. Correction of the field variations caused by manufacturing tolerances and environmental effects are made with a combination of superconducting shims and passive shims. Modern UHF magnets operate in zero boil-off mode with the use of cryocoolers with cooling capacity at 4.2 K. Although there are no cryogen costs associated with normal operation UHF magnets require a significant volume (10 000–20 000 l) of liquid helium for the cool-down. Liquid helium is expensive therefore new methods of cool-down using high-power cryocoolers are being implemented to reduce the requirement.

  8. Ultra-high field magnets for whole-body MRI

    NASA Astrophysics Data System (ADS)

    Warner, Rory

    2016-09-01

    For whole-body MRI, an ultra-high field (UHF) magnet is currently defined as a system operating at 7 T or above. Over 70 UHF magnets have been built, all with the same technical approach originally developed by Magnex Scientific Ltd. The preferred coil configuration is a compensated solenoid. In this case, the majority of the field is generated by a simple long solenoid that stretches the entire length of the magnet. Additional coils are wound on a separate former outside the main windings with the purpose of balancing the homogeneity. Most of the magnets currently in operation are passively shielded systems where the magnet is surrounded by a steel box of 200-870 tonnes of carbon steel. More recently actively shielded magnets have been built for operation at 7 T; in this case the stray field is controlled by with reverse turns wound on a separate former outside the primary coils. Protection against quench damage is much more complex with an actively shielded magnet design due to the requirement to prevent the stray field from increasing during a quench. In the case of the 7 T 900 magnet this controlled by combining some of the screening coils into each section of the protection circuit. Correction of the field variations caused by manufacturing tolerances and environmental effects are made with a combination of superconducting shims and passive shims. Modern UHF magnets operate in zero boil-off mode with the use of cryocoolers with cooling capacity at 4.2 K. Although there are no cryogen costs associated with normal operation UHF magnets require a significant volume (10 000-20 000 l) of liquid helium for the cool-down. Liquid helium is expensive therefore new methods of cool-down using high-power cryocoolers are being implemented to reduce the requirement.

  9. Developments at the High Field Magnet Laboratory in Nijmegen

    NASA Astrophysics Data System (ADS)

    Perenboom, J. A. A. J.; Maan, J. C.; van Breukelen, M. R.; Wiegers, S. A. J.; den Ouden, A.; Wulffers, C. A.; van der Zande, W. J.; Jongma, R. T.; van der Meer, A. F. G.; Redlich, B.

    2013-03-01

    The High Field Magnet Laboratory at the Radboud University Nijmegen is rapidly expanding its capabilities. The developments encompass both organizational changes and new possibilities for research. The organization of the HFML was strengthened as a consequence of stronger participation of the Foundation for Fundamental Research on Matter (FOM), and an increase of the core-funding. This change makes that HFML is now considered on a national level as large research facility that operates at an international scale. At the same time work is underway to build new and powerful magnets, and provide electromagnetic radiation for magneto-spectroscopic studies. Electromagnetic radiation in the infrared and far-infrared spectrum will soon be available in the HFML with wavelengths between 3 μm and 1.5 mm, produced by the `FELIX' facility, comprising the long-wavelength free electron laser `FLARE' that in September 2011 produced its first light and the free electron lasers that have been moved from Rijnhuizen to Nijmegen. In magnet technology great strides are made to make magnets available for the user community with unprecedented performance: late in 2012 we hope to commission a new all-resistive magnet system that will generate a steady magnetic field as high as 38 T, by fully exploiting the maximum power of the installation, i.e. 20 MW, and using all available improvements in the design and construction of `Florida-Bitter' resistive magnets. We are also well underway with the design of a 45 T hybrid magnet system, using Nb3Sn superconductors and wind-and-react Cable-in-Conduit technology.

  10. Intermediate length scale organisation in tin borophosphate glasses: new insights from high field correlation NMR.

    PubMed

    Tricot, G; Saitoh, A; Takebe, H

    2015-11-28

    The structure of tin borophosphate glasses, considered for the development of low temperature sealing glasses or anode materials for Li-batteries, has been analysed at the intermediate length scale by a combination of high field standard and advanced 1D/2D nuclear magnetic resonance techniques. The nature and extent of B/P mixing were analysed using the (11)B((31)P) dipolar heteronuclear multiple quantum coherence NMR sequence and the data interpretation allowed (i) detecting the presence and analysing the nature of the B-O-P linkages, (ii) re-interpreting the 1D (31)P spectra and (iii) extracting the proportion of P connected to borate species. Interaction between the different borate species was analysed using the (11)B double quantum-simple quantum experiment to (i) investigate the presence and nature of the B-O-B linkage, (ii) assign the different borate species observed all along the composition line and (iii) monitor the borate network formation. In addition, (119)Sn static NMR was used to investigate the evolution of the chemical environment of the tin polyhedra. Altogether, the set of data allowed determining the structural units constituting the glass network and quantifying the extent of B/P mixing. The structural data were then used to explain the non-linear and unusual evolution of the glass transition temperature.

  11. Modeling the high-field section of a muon helical cooling channel

    SciTech Connect

    Zlobin, A.V.; Barzi, E.; Kashikhin, V.S.; Lamm, M.J.; Lombardo, V.; Lopes, M.L.; Yu, M.; Johnson, R.P.; Flanagan, G.; Kahn, S.A.; Turenne, M.; /MUONS Inc., Batavia

    2010-05-01

    This paper describes the conceptual design and parameters of a short model of a high-field helical solenoid for muon beam cooling. Structural materials choices, fabrication techniques and first test results are discussed.

  12. Very-high-field magnetic resonance imaging: instrumentation and safety issues.

    PubMed

    Kelley, D A; Schenck, J F

    1999-02-01

    Because of their advantage in terms of signal-to-noise ratio, high-field magnetic resonance imaging systems have become favored in the last few years for functional magnetic resonance imaging (fMRI) applications. In many ways the conceptual development of these high-field scanners has involved more-or-less straightforward extensions of practices at lower field strengths. However, in other ways specific engineering challenges have been encountered and largely overcome in the quest for scanners capable of realizing the advantages of high-field systems. An understanding of the technical trade-offs that can be made in terms of hardware performance is useful in deciding on the optimum system for a given fMRI application. In this article the technical issues surrounding high-field scanning are reviewed in the context of a typical brain mapping protocol. In addition there is a discussion of the safety issues related to the use of these systems.

  13. High Field Magnetization measurements of uranium dioxide single crystals (P08358- E003-PF)

    SciTech Connect

    Gofryk, K.; Harrison, N.; Jaime, M.

    2014-12-01

    Our preliminary high field magnetic measurements of UO2 are consistent with a complex nature of the magnetic ordering in this material, compatible with the previously proposed non-collinear 3-k magnetic structure. Further extensive magnetic studies on well-oriented (<100 > and <111>) UO2 crystals are planned to address the puzzling behavior of UO2 in both antiferromagnetic and paramagnetic states at high fields.

  14. Multicomponent analysis of radiolytic products in human body fluids using high field proton nuclear magnetic resonance (NMR) spectroscopy

    NASA Astrophysics Data System (ADS)

    Grootveld, Martin C.; Herz, Herman; Haywood, Rachel; Hawkes, Geoffrey E.; Naughton, Declan; Perera, Anusha; Knappitt, Jacky; Blake, David R.; Claxson, Andrew W. D.

    1994-05-01

    High field proton Hahn spin-echo nuclear magnetic resonance (NMR) spectroscopy has been employed to investigate radiolytic damage to biomolecules present in intact human body fluids. γ-Radiolysis of healthy or rheumatoid human serum (5.00 kGy) in the presence of atmospheric O 2 gave rise to reproducible elevations in the concentration of NMR-detectable acetate which are predominantly ascribable to the prior oxidation of lactate to pyruvate by hydroxyl radical (·OH) followed by oxidative decarboxylation of pyruvate by radiolytically-generated hydrogen peroxide (H 2O 2) and/or further ·OH radical. Increases in the serum levels of non-protein-bound, low-molecular-mass components such as citrate and glutamine were also observed subsequent to γ-radiolysis, an observation which may reflect their mobilisation from protein binding-sites by ·OH radical, superoxide anion and/or H 2O 2. Moreover, substantial radiolytically-mediated elevations in the concentration of serum formate were also detectable. In addition to the above modifications, γ-radiolysis of inflammatory knee-joint synovial fluid (SF) generated a low-molecular-mass oligosaccharide species derived from the radiolytic fragmentation of hyaluronate. The radiolytically-mediated production of acetate in SF samples was markedly greater than that observed in serum samples, a consequence of the much higher levels of ·OH radical-scavenging lactate present. Indeed, increases in SF acetate concentration were detectable at doses as low as 48 Gy. We conclude that high field proton NMR analysis provides much useful information regarding the relative radioprotectant abilities of endogenous components and the nature, status and levels of radiolytic products generated in intact biofluids. We also suggest that NMR-detectable radiolytic products with associated toxicological properties (e.g. formate) may play a role in contributing to the deleterious effects observed following exposure of living organisms to sources of

  15. Alpha channeling with high-field launch of lower hybrid waves

    SciTech Connect

    Ochs, I. E.; Bertelli, N.; Fisch, N. J.

    2015-11-15

    Although lower hybrid waves are effective at driving currents in present-day tokamaks, they are expected to interact strongly with high-energy particles in extrapolating to reactors. In the presence of a radial alpha particle birth gradient, this interaction can take the form of wave amplification rather than damping. While it is known that this amplification more easily occurs when launching from the tokamak high-field side, the extent of this amplification has not been made quantitative. Here, by tracing rays launched from the high-field-side of a tokamak, the required radial gradients to achieve amplification are calculated for a temperature and density regime consistent with a hot-ion-mode fusion reactor. These simulations, while valid only in the linear regime of wave amplification, nonetheless illustrate the possibilities for wave amplification using high-field launch of the lower hybrid wave.

  16. Alpha channeling with high-field launch of lower hybrid waves

    SciTech Connect

    Ochs, I. E.; Bertelli, N.; Fisch, N. J.

    2015-11-04

    Although lower hybrid waves are effective at driving currents in present-day tokamaks, they are expected to interact strongly with high-energy particles in extrapolating to reactors. In the presence of a radial alpha particle birth gradient, this interaction can take the form of wave amplification rather than damping. While it is known that this amplification more easily occurs when launching from the tokamak high-field side, the extent of this amplification has not been made quantitative. Here, by tracing rays launched from the high- field-side of a tokamak, the required radial gradients to achieve amplification are calculated for a temperature and density regime consistent with a hot-ion-mode fusion reactor. As a result, these simulations, while valid only in the linear regime of wave amplification, nonetheless illustrate the possibilities for wave amplification using high-field launch of the lower hybrid wave.

  17. Alpha channeling with high-field launch of lower hybrid waves

    DOE PAGES

    Ochs, I. E.; Bertelli, N.; Fisch, N. J.

    2015-11-04

    Although lower hybrid waves are effective at driving currents in present-day tokamaks, they are expected to interact strongly with high-energy particles in extrapolating to reactors. In the presence of a radial alpha particle birth gradient, this interaction can take the form of wave amplification rather than damping. While it is known that this amplification more easily occurs when launching from the tokamak high-field side, the extent of this amplification has not been made quantitative. Here, by tracing rays launched from the high- field-side of a tokamak, the required radial gradients to achieve amplification are calculated for a temperature and densitymore » regime consistent with a hot-ion-mode fusion reactor. As a result, these simulations, while valid only in the linear regime of wave amplification, nonetheless illustrate the possibilities for wave amplification using high-field launch of the lower hybrid wave.« less

  18. Nb$_3$Sn High Field Magnets for the High Luminosity LHC Upgrade Project

    SciTech Connect

    Ambrosio, Giorgio

    2015-01-01

    The High Luminosity upgrade of the Large Hadron Collider at CERN requires a new generation of high field superconducting magnets. High field large aperture quadrupoles (MQXF) are needed for the low-beta triplets close to the ATLAS and CMS detectors, and high field two-in-one dipoles (11 T dipoles) are needed to make room for additional collimation. The MQXF quadrupoles, with a field gradient of 140 T/m in 150 mm aperture, have a peak coil field of 12.1 T at nominal current. The 11 T dipoles, with an aperture of 60 mm, have a peak coil field of 11.6 T at nominal current. Both magnets require Nb3Sn conductor and are the first applications of this superconductor to actual accelerator magnets.

  19. High-field magnets using high-critical-temperature superconducting thin films

    DOEpatents

    Mitlitsky, Fred; Hoard, Ronald W.

    1994-01-01

    High-field magnets fabricated from high-critical-temperature superconducting ceramic (HTSC) thin films which can generate fields greater than 4 Tesla. The high-field magnets are made of stackable disk-shaped substrates coated with HTSC thin films, and involves maximizing the critical current density, superconducting film thickness, number of superconducting layers per substrate, substrate diameter, and number of substrates while minimizing substrate thickness. The HTSC thin films are deposited on one or both sides of the substrates in a spiral configuration with variable line widths to increase the field.

  20. High-field magnets using high-critical-temperature superconducting thin films

    DOEpatents

    Mitlitsky, F.; Hoard, R.W.

    1994-05-10

    High-field magnets fabricated from high-critical-temperature superconducting ceramic (HTSC) thin films which can generate fields greater than 4 Tesla are disclosed. The high-field magnets are made of stackable disk-shaped substrates coated with HTSC thin films, and involves maximizing the critical current density, superconducting film thickness, number of superconducting layers per substrate, substrate diameter, and number of substrates while minimizing substrate thickness. The HTSC thin films are deposited on one or both sides of the substrates in a spiral configuration with variable line widths to increase the field. 4 figures.

  1. Fabrication of Plasma Transient Density Structures and its Application to High-Field Plasma Devices

    SciTech Connect

    Chen Szuyuan; Wang Jyhpyng; Lin Jiunnyuan

    2006-11-27

    Fabrications of plasma transient density structures such as plasma waveguide, variable gas jet length, longitudinal density structure, and transverse wiggler by using laser machining in a gas jet are presented. The implementations of the technique of variable gas jet length with laser machining to achieve tomographic diagnosis of laser wakefield electron acceleration, x-ray lasing, and high harmonic generation are reported. Applications of these elements of high-field plasma devices and their combinations to enhance the products in high-field physics are presented or proposed.

  2. The spheromak as a prototype for ultra-high-field superconducting magnets

    SciTech Connect

    Furth, H.P.; Jardin, S.C.

    1987-08-01

    In view of current progress in the development of superconductor materials, the ultimate high-field limit of superconducting magnets is likely to be set by mechanical stress problems. Maximum field strength should be attainable by means of approximately force-free magnet windings having favorable ''MHD'' stability properties (so that small winding errors will not grow). Since a low-beta finite-flux-hole spheromak configuration qualifies as a suitable prototype, the theoretical and experimental spheromak research effort of the past decade has served to create a substantial technical basis for the design of ultra-high-field superconducting coils. 11 refs.

  3. 15 Years of R&D on high field accelerator magnets at FNAL

    DOE PAGES

    Barzi, Emanuela; Zlobin, Alexander V.

    2016-07-01

    The High Field Magnet (HFM) Program at Fermi National Accelerator Laboratory (FNAL) has been developing Nb3Sn superconducting magnets, materials and technologies for present and future particle accelerators since the late 1990s. This paper summarizes the main results of the Nb3Sn accelerator magnet and superconductor R&D at FNAL and outlines the Program next steps.

  4. Perspectives and limitations of parallel MR imaging at high field strengths.

    PubMed

    Heidemann, Robin M; Seiberlich, Nicole; Griswold, Mark A; Wohlfarth, Katrin; Krueger, Gunnar; Jakob, Peter M

    2006-05-01

    In medical magnetic resonance imaging (MRI) imaging, it is standard practice to use MR scanners with a field strength of 1.5 Tesla. Recently, an ongoing trend towards higher field strengths can be observed, with a new potential clinical standard of 3.0 Tesla. High-field MR imaging, with its intrinsic higher signal-to-noise ratio (SNR), can enable new applications for MRI in medical diagnosis, or can serve to improve existing methods. The use of high field MRI is not without its limitations, however. Besides SNR, other unwanted effects increase with a higher field strength. Without correction, these high field problems can cause a serious loss in image quality. An elegant way to address these problems is the use of parallel imaging. In many clinical applications, parallel MRI (pMRI) is part of the standard protocol, as pMRI can enhance virtually every MRI application without necessarily affecting the contrast behavior of the underlying imaging sequence. In addition to the speed advantages offered by pMRI, the capability of parallel imaging to reduce significant high field-specific problems, thereby improving image quality, will be of major importance.

  5. U.S. EPA High-Field NMR Facility with Remote Accessibility

    EPA Science Inventory

    EPA’s High-Field Nuclear Magnetic Resonance Research Facility housed in Athens, GA has two Varian 600 MHz NMR spectrometers used for conducting sophisticated experiments in environmental science. Off-site users can ship their samples and perform their NMR experiments remotely fr...

  6. Narrowband Emission in Compton/Thomson Sources Operating in the High-Field Regime

    DOE PAGES

    Terzic, Balsa; Deitrick, Kirsten E.; Hofler, Alicia S.; Kraff, Geoffrey A.

    2014-02-21

    We present a novel and quite general analysis of the interaction of a high-field chirped laser pulse and a relativistic electron, in which exquisite control of the spectral brilliance of the upshifted Thomson-scattered photon is shown to be possible. Normally, when Thomson scattering occurs at high field strengths, there is ponderomotive line broadening in the scattered radiation. This effect makes the bandwidth too large for some applications, and reduces the spectral brilliance. In this paper we show that such broadening can be corrected and eliminated by suitable frequency modulation of the incident laser pulse. Further, we suggest a practical realizationmore » of this compensation idea in terms of a chirped-beam driven FEL oscillator configuration, and show that significant compensation can occur, even with the imperfect matching to be expected in these conditions.« less

  7. Polarization-tunable terahertz radiation in the high-field regime.

    PubMed

    Chen, Zi-Yu; Pukhov, Alexander

    2016-06-01

    Polarization control of terahertz (THz) pulses in the high-field regime is a challenging subject. Here we propose and numerically demonstrate an all-optical scheme to generate a polarization-tunable high-field THz source based on relativistic laser plasma interactions. By adjusting the polarization state of the driving laser, collective oscillation of the plasmas can be steered. Phase difference between the laser field components is inherited in the plasma dynamics, as well as in the resulting THz generation process. Single-cycle extremely intense THz pulses with field strength ∼  GV/cm can be generated. The THz polarization state can be tuned from linear through elliptical to circular by changing the polarization state of the driving laser. PMID:27244439

  8. Open half-volume quadrature transverse electromagnetic coil for high-field magnetic resonance imaging.

    PubMed

    Peshkovsky, A S; Kennan, R P; Fabry, M E; Avdievich, N I

    2005-04-01

    A half-volume quadrature head transverse electromagnetic (TEM) coil has been constructed for 4 T imaging applications. This coil produces a sufficiently large homogeneous B(1) field region for the use as a volume coil. It provides superior transmission efficiency, resulting in significantly lower power deposition, as well as greater sensitivity and improved patient comfort and accessibility compared with conventional full-volume coils. Additionally, this coil suppresses the RF penetration artifact that distorts the RF magnetic field profile and alters the intensity in high-field images recorded with linear surface and volume coils. These advantages make it possible to apply this device as an efficient transmit/receive coil for high-field imaging with a restricted field of view.

  9. Narrowband Emission in Compton/Thomson Sources Operating in the High-Field Regime

    SciTech Connect

    Terzic, Balsa; Deitrick, Kirsten E.; Hofler, Alicia S.; Kraff, Geoffrey A.

    2014-02-21

    We present a novel and quite general analysis of the interaction of a high-field chirped laser pulse and a relativistic electron, in which exquisite control of the spectral brilliance of the upshifted Thomson-scattered photon is shown to be possible. Normally, when Thomson scattering occurs at high field strengths, there is ponderomotive line broadening in the scattered radiation. This effect makes the bandwidth too large for some applications, and reduces the spectral brilliance. In this paper we show that such broadening can be corrected and eliminated by suitable frequency modulation of the incident laser pulse. Further, we suggest a practical realization of this compensation idea in terms of a chirped-beam driven FEL oscillator configuration, and show that significant compensation can occur, even with the imperfect matching to be expected in these conditions.

  10. High field superconducting magnets (12 T and greater) for fusion applications

    SciTech Connect

    Miller, J.R.; Summers, L.T.; Kerns, J.A.

    1986-07-09

    The technology for producing high fields in large superconducting magnets has increased greatly in recent years, but must increase still more in the future. In this paper, we examine the present state of the art vis-a-vis the needs of a next-generation fusion machine and outline a program to provide for those needs. We also highlight recent developments that suggest the program goals are within reach.

  11. Perspectives for the high field approach in fusion research and advances within the Ignitor Program

    NASA Astrophysics Data System (ADS)

    Coppi, B.; Airoldi, A.; Albanese, R.; Ambrosino, G.; Belforte, G.; Boggio-Sella, E.; Cardinali, A.; Cenacchi, G.; Conti, F.; Costa, E.; D'Amico, A.; Detragiache, P.; De Tommasi, G.; DeVellis, A.; Faelli, G.; Ferraris, P.; Frattolillo, A.; Giammanco, F.; Grasso, G.; Lazzaretti, M.; Mantovani, S.; Merriman, L.; Migliori, S.; Napoli, R.; Perona, A.; Pierattini, S.; Pironti, A.; Ramogida, G.; Rubinacci, G.; Sassi, M.; Sestero, A.; Spillantini, S.; Tavani, M.; Tumino, A.; Villone, F.; Zucchi, L.

    2015-05-01

    The Ignitor Program maintains the objective of approaching D-T ignition conditions by incorporating systematical advances made with relevant high field magnet technology and with experiments on high density well confined plasmas in the present machine design. An additional objective is that of charting the development of the high field line of experiments that goes from the Alcator machine to the ignitor device. The rationale for this class of experiments, aimed at producing poloidal fields with the highest possible values (compatible with proven safety factors of known plasma instabilities) is given. On the basis of the favourable properties of high density plasmas produced systematically by this line of machines, the envisioned future for the line, based on novel high field superconducting magnets, includes the possibility of investigating more advanced fusion burn conditions than those of the D-T plasmas for which Ignitor is designed. Considering that a detailed machine design has been carried out (Coppi et al 2013 Nucl. Fusion 53 104013), the advances made in different areas of the physics and technology that are relevant to the Ignitor project are reported. These are included within the following sections of the present paper: main components issues, assembly and welding procedures; robotics criteria; non-linear feedback control; simulations with three-dimensional structures and disruption studies; ICRH and dedicated diagnostics systems; anomalous transport processes including self-organization for fusion burning regimes and the zero-dimensional model; tridimensional structures of the thermonuclear instability and control provisions; superconducting components of the present machine; envisioned experiments with high field superconducting magnets.

  12. Anomaly of the rotational nonergodicity parameter of glass formers probed by high field electron paramagnetic resonance

    NASA Astrophysics Data System (ADS)

    Bercu, V.; Martinelli, M.; Massa, C. A.; Pardi, L. A.; Rössler, E. A.; Leporini, D.

    2008-08-01

    Exploiting the high angular resolution of high field electron paramagnetic resonance measured at 95, 190, and 285 GHz we determine the rotational nonergodicity parameter of different probe molecules in the glass former o-terphenyl and polybutadiene in a model-independent way. Our results clearly show a characteristic change in the temperature of the nonergodicity parameter proving a rather sharp dynamic crossover in both systems, in contrast to previous results from other techniques.

  13. Construction of block-coil high-field model dipoles for future hadron colliders

    SciTech Connect

    Blackburn, Raymond; Elliott, Tim; Henchel, William; McInturff, Al; McIntyre, Peter; Sattarov, Akhdior

    2002-08-04

    A family of high-field dipoles is being developed at Texas A&M University, as part of the program to improve the cost-effectiveness of superconducting magnet technology for future hadron colliders. The TAMU technology employs stress management, flux-plate control of persistent-current multipoles, conductor optimization using mixed-strand cable, and metal-filled bladders to provide pre-load and surface compliance. Construction details and status of the latest model dipole will be presented.

  14. Lattices for a high-field 30 TeV hadron collider

    SciTech Connect

    Peggs, S.; Dell, F.; Harrison, M.; Syphers, M.; Tepikian, S.

    1996-12-01

    Long arc cells would lead to major cost savings in a high field high T{sub c} hadron collider, operating in the regime of significant synchrotron radiation. Two such lattices, with half cell lengths of 110 and 260 m, are compared. Both allow flexible tuning, and have large dynamic apertures when dominated by chromatic sextupoles. Lattices with longer cells are much more sensitive to systematic magnet errors, which are expected to dominate.

  15. Ultra-high field magnetic resonance imaging of the basal ganglia and related structures

    PubMed Central

    Plantinga, Birgit R.; Temel, Yasin; Roebroeck, Alard; Uludağ, Kâmil; Ivanov, Dimo; Kuijf, Mark L.; ter Haar Romenij, Bart M.

    2014-01-01

    Deep brain stimulation is a treatment for Parkinson's disease and other related disorders, involving the surgical placement of electrodes in the deeply situated basal ganglia or thalamic structures. Good clinical outcome requires accurate targeting. However, due to limited visibility of the target structures on routine clinical MR images, direct targeting of structures can be challenging. Non-clinical MR scanners with ultra-high magnetic field (7T or higher) have the potential to improve the quality of these images. This technology report provides an overview of the current possibilities of visualizing deep brain stimulation targets and their related structures with the aid of ultra-high field MRI. Reviewed studies showed improved resolution, contrast- and signal-to-noise ratios at ultra-high field. Sequences sensitive to magnetic susceptibility such as T2* and susceptibility weighted imaging and their maps in general showed the best visualization of target structures, including a separation between the subthalamic nucleus and the substantia nigra, the lamina pallidi medialis and lamina pallidi incompleta within the globus pallidus and substructures of the thalamus, including the ventral intermediate nucleus (Vim). This shows that the visibility, identification, and even subdivision of the small deep brain stimulation targets benefit from increased field strength. Although ultra-high field MR imaging is associated with increased risk of geometrical distortions, it has been shown that these distortions can be avoided or corrected to the extent where the effects are limited. The availability of ultra-high field MR scanners for humans seems to provide opportunities for a more accurate targeting for deep brain stimulation in patients with Parkinson's disease and related disorders. PMID:25414656

  16. A Common Coil Design for High Field 2-in-1 Accelerator Magnets^*.

    NASA Astrophysics Data System (ADS)

    Gupta, R.

    1997-05-01

    This paper presents a common coil design concept for 2-in-1 superconducting accelerator magnets. It practically eliminates the major problems in the ends of high field magnets built with either high temperature or conventional superconductors. Racetrack coils, consisting of rectangular blocks built with either superconducting cables or tapes, are common to both apertures with each aperture containing one half of each coil. The two apertures are in the same vertical plane in an over-under geometry. A set of common flat coils are placed vertically on left and right side of the two apertures producing field in the opposite directions. The ends are easy to wind with the conductors experiencing little strain. The ends can be fully supported by a simple 2-d geometry to contain the large Lorentz forces. The overall magnet design, construction and tooling are also expected to be simpler than in conventional cosine theta magnets. The block design for high field magnets uses more conductor than the cosine theta design but is preferred for dealing with the large Lorentz forces in the body of the magnet. The concept is also suitable for a variety of other high field superconducting, moderate field superferric, multi-aperture and combined function magnet designs. ^*Work supported by the U.S. Department of Energy.

  17. Overcoming the low relaxivity of gadofosveset at high field with spin locking.

    PubMed

    Richardson, O C; Scott, M L J; Tanner, S F; Waterton, J C; Buckley, D L

    2012-10-01

    The contrast agent gadofosveset, which binds reversibly to serum albumin, has a high longitudinal relaxivity at lower magnetic fields (≤3.0 T) but a much lower relaxivity at high fields. Spin locking is sensitive to macromolecular content; it is hypothesized that combining this technique with the albumin-binding properties of gadofosveset may enable increased relaxivity at high fields. In vitro measurements at 4.7 T found significantly higher spin-lock relaxation rates, R1ρ (1/T1ρ), when gadofosveset was serum albumin-bound than when unbound. R1ρ values for a nonbinding contrast agent (gadopentetate dimeglumine) in serum albumin were similar to those for unbound gadofosveset. R2 (1/T2) values were also significantly higher at 4.7 T for serum albumin-bound gadofosveset than for unbound. Spin locking at high field generates significantly higher relaxation rates for gadofosveset than conventional contrast agents and may provide a method for differentiating free and bound molecules at these field strengths.

  18. Measuring remanence anisotropy of hematite in red beds: anisotropy of high-field isothermal remanence magnetization (hf-AIR)

    NASA Astrophysics Data System (ADS)

    Bilardello, Dario; Kodama, Kenneth P.

    2009-09-01

    The potential of using high-field anisotropy of isothermal remanence magnetization (hf-AIR) measurements for determining the origin of natural remanent magnetization in red beds and for identifying and correcting possible red-bed inclination shallowing was investigated for specimens of the Carboniferous Shepody Formation of New Brunswick and Nova Scotia, Canada. The technique makes it possible for a typical paleomagnetic laboratory to measure the remanence anisotropy of high-coercivity hematite. High-field (hf) AIR was used in conjunction with 100 mT alternating field (af) and 120°C thermal demagnetization to separate the contribution of hematite to the remanence anisotropy from that of magnetite/maghemite and goethite, respectively. A 5-T impulse DC magnetic field was used for the hf-AIR to reset the magnetic moment of high-coercivity hematite so that demagnetization between AIR orientations was not necessary. The ability of a 5-T field to reset the magnetization was tested by generating an isothermal remanent magnetization acquisition curve for hematite by using impulse DC magnetic fields up to 5 T in one orientation and followed by applying a field in the opposite direction at each step. Each field application was treated by 120°C heating and 100 mT af demagnetization before measurement. At 5 T, the difference between the magnetizations applied in opposite directions disappeared indicating that no magnetic memory persisted at this field strength. We performed a validity and reproducibility test of our hf-AIR measurement technique by measuring three specimens multiple times along two orthogonal coordinate systems. The method yielded highly reproducible results and, on rotating the specimen's coordinates, the fabric rotated by 90° as expected, showing that it is not an artifact of the technique. We also measured hf-AIR on samples that had previously been chemically demagnetized in 3N HCl to remove the secondary, chemically grown pigmentary hematite. The hf

  19. Stress management as an enabling technology for high-field superconducting dipole magnets

    NASA Astrophysics Data System (ADS)

    Holik, Eddie Frank, III

    This dissertation examines stress management and other construction techniques as means to meet future accelerator requirement demands by planning, fabricating, and analyzing a high-field, Nb3Sn dipole. In order to enable future fundamental research and discovery in high energy accelerator physics, bending magnets must access the highest fields possible. Stress management is a novel, propitious path to attain higher fields and preserve the maximum current capacity of advanced superconductors by managing the Lorentz stress so that strain induced current degradation is mitigated. Stress management is accomplished through several innovative design features. A block-coil geometry enables an Inconel pier and beam matrix to be incorporated in the windings for Lorentz Stress support and reduced AC loss. A laminar spring between windings and mica paper surrounding each winding inhibit any stress transferral through the support structure and has been simulated with ALGORRTM. Wood's metal filled, stainless steel bladders apply isostatic, surface-conforming preload to the pier and beam support structure. Sufficient preload along with mica paper sheer release reduces magnet training by inhibiting stick-slip motion. The effectiveness of stress management is tested with high-precision capacitive stress transducers and strain gauges. In addition to stress management, there are several technologies developed to assist in the successful construction of a high-field dipole. Quench protection has been designed and simulated along with full 3D magnetic simulation with OPERARTM. Rutherford cable was constructed, and cable thermal expansion data was analysed after heat treatment. Pre-impregnation analysis techniques were developed due to elemental tin leakage in varying quantities during heat treatment from each coil. Robust splicing techniques were developed with measured resistivites consistent with nO joints. Stress management has not been incorporated by any other high field dipole

  20. High field dc conduction current and spectroscopy of aged transformer oil

    SciTech Connect

    El-Sulaiman, A.A.; Ahmed, O.; Hassan, M.M.; Quresh, M.

    1982-11-01

    This paper studies the experimental results of the quasi-state high field dc conduction current, and changes occuring in the molecular structure of aged transformer oil, sampled from EHV transformer operating for the last five years. Aged oil was compared with fresh transformer oil and liquid paraffin. It was found that aged oil exhibits higher conduction than both of the other oils through 600 seconds of field application. However, no molecular changes were detected using different techniques of spectroscopy such as GC; UV; IR and NMR. Metallic impurities were found to be of the same order but the acidity increased manifolds to that of fresh oil.

  1. Fabrication of spatial transient-density structures as high-field plasma photonic devices

    SciTech Connect

    Pai, C.-H.; Huang, S.-Y.; Kuo, C.-C.; Lin, M.-W.; Wang, J.; Chen, S.-Y.; Lee, C.-H.; Lin, J.-Y.

    2005-07-15

    Fabrication of periodic transient-density structures in a gas jet with a boundary scale length approaching 10 {mu}m was demonstrated. This was achieved by passing an ultrashort high-intensity laser pulse through a patterned mask and imaging the mask onto the target plane. Gas/plasma density at the laser-irradiated regions drops as a result of hydrodynamic expansion following ionization and heating by the laser pulse. The fabrication of gas/plasma density structures with such a scheme is an essential step in the development of plasma photonic devices for applications in high-field physics.

  2. High-Field Magnetization of the Pyrochlore Compound Gd2Ti2O7

    NASA Astrophysics Data System (ADS)

    Narumi, Yasuo; Kikkawa, Akiko; Katsumata, Koichi; Honda, Zentaro; Hagiwara, Masayuki; Kindo, Koichi

    2006-09-01

    High-field magnetization measurements have been preformed on a single crystal sample of the pyrochlore compound Gd2Ti2O7 using a pulse magnet in conjunction with a dilution refrigerator. The magnetization curve at 0.3 K reveals two magnetic phase transitions when the magnetic field is applied along b [111]. At temperatures slightly above TN, a magnetization plateau appears around 5 T and the magnetization increases again from about 15 T with a convex curvature. It is considered that this crossover is due to a competition among thermal fluctuations, short-range antiferromagnetic ordering and geometrical frustration.

  3. Single-shot spatiotemporal measurements of high-field terahertz pulses

    SciTech Connect

    van Tilborg, Jeroen; Schroeder, Carl; Toth, Csaba; Geddes, Cameron; Esarey, Eric; Leemans, Wim

    2011-06-17

    The electric field profiles of broad-bandwidth coherent terahertz (THz) pulses, emitted by laser-wakefield-accelerated electron bunches, are studied. The near-single-cycle THz pulses are measured with two single-shot techniques in the temporal and spatial domains. Spectra of 0-6 THz and peak fields up to {approx_equal} 0.4 MV cm{sup -1} are observed. The measured field substructure demonstrates the manifestation of spatiotemporal coupling at focus, which affects the interpretation of THz radiation as a bunch diagnostic and in high-field pump-probe experiments.

  4. Observation of Thermoelectric Currents in High-Field Superconductor-Ferromagnet Tunnel Junctions.

    PubMed

    Kolenda, S; Wolf, M J; Beckmann, D

    2016-03-01

    We report on the experimental observation of spin-dependent thermoelectric currents in superconductor-ferromagnet tunnel junctions in high magnetic fields. The thermoelectric signals are due to a spin-dependent lifting of the particle-hole symmetry, and are found to be in excellent agreement with recent theoretical predictions. The maximum Seebeck coefficient inferred from the data is about -100  μV/K, much larger than commonly found in metallic structures. Our results directly prove the coupling of spin and heat transport in high-field superconductors.

  5. Oxypnictide SmFeAs(O,F) superconductor: a candidate for high-field magnet applications.

    PubMed

    Iida, Kazumasa; Hänisch, Jens; Tarantini, Chiara; Kurth, Fritz; Jaroszynski, Jan; Ueda, Shinya; Naito, Michio; Ichinose, Ataru; Tsukada, Ichiro; Reich, Elke; Grinenko, Vadim; Schultz, Ludwig; Holzapfel, Bernhard

    2013-01-01

    The recently discovered oxypnictide superconductor SmFeAs(O,F) is the most attractive material among the Fe-based superconductors due to its highest transition temperature of 56 K and potential for high-field performance. In order to exploit this new material for superconducting applications, the knowledge and understanding of its electro-magnetic properties are needed. Recent success in fabricating epitaxial SmFeAs(O,F) thin films opens a great opportunity to explore their transport properties. Here we report on a high critical current density of over 10(5) A/cm(2) at 45 T and 4.2 K for both main field orientations, feature favourable for high-field magnet applications. Additionally, by investigating the pinning properties, we observed a dimensional crossover between the superconducting coherence length and the FeAs interlayer distance at 30-40 K, indicative of a possible intrinsic Josephson junction in SmFeAs(O,F) at low temperatures that can be employed in electronics applications such as a terahertz radiation source and a superconducting Qubit.

  6. Magnetism in CeRhIn5 at high fields measured by NMR

    NASA Astrophysics Data System (ADS)

    Mounce, A. M.; Ronning, F.; Bauer, E. D.; Thompson, J. D.; Reyes, A. P.; Kuhns, P. L.

    2015-03-01

    De Haas-van Alphen measurements of CeRhIn5 at ambient pressure show an abrupt change in the Fermi surface volume at high fields, H* ~ 30 T, and low temperatures resulting in antiferromagnetic phases with a small Fermi surface at fields below H* and a large Fermi surface at fields H such that H* < H < 50 T. Nuclear magnetic resonance (NMR) is the ideal probe for these magnetic states as the microscopic details are still lacking. Our preliminary NMR measurements find the magnetic order for H ∥ c is incommensurate up to 30 T as opposed to H ⊥ c which transitions from incommensurate to commensurate at H ~ 2 T. Furthermore, we find that the magnetic moment decreases near 17 T for H ∥ c . These measurements provide an insight into the magnetic anisotropy of CeRhIn5 and are a crucial step to studying its high field phases. Work at Los Alamos was performed under the auspices of the U.S. DOE, Office of Basic Energy Science, Division of Materials and Engineering.

  7. Prostate MR imaging at high-field strength: evolution or revolution?

    PubMed

    Rouvière, Olivier; Hartman, Robert P; Lyonnet, Denis

    2006-02-01

    As 3 T MR scanners become more available, body imaging at high field strength is becoming the subject of intensive research. However, little has been published on prostate imaging at 3 T. Will high-field imaging dramatically increase our ability to depict and stage prostate cancer? This paper will address this question by reviewing the advantages and drawbacks of body imaging at 3 T and the current limitations of prostate imaging at 1.5 T, and by detailing the preliminary results of prostate 3 T MRI. Even if slight adjustments of imaging protocols are necessary for taking into account the changes in T1 and T2 relaxation times at 3 T, tissue contrast in T2-weighted (T2w) imaging seems similar at 1.5 T and 3 T. Therefore, significant improvement in cancer depiction in T2w imaging is not expected. However, increased spatial resolution due to increased signal-to-noise ratio (SNR) may improve the detection of minimal capsular invasion. Higher field strength should provide increased spectral and spatial resolution for spectroscopic imaging, but new pulse sequences will have to be designed for overcoming field inhomogeneities and citrate J-modulation issues. Finally, dynamic contrast-enhanced MRI is the method of imaging that is the most likely to benefit from the increased SNR, with a significantly better trade-off between temporal and spatial resolution.

  8. High field volume coil with unbalance current distribution for MRI applications of rodents

    NASA Astrophysics Data System (ADS)

    Marrufo, O. R.; Hernández, J.; Rodríguez, A. O.

    2010-12-01

    The development of transceiver volume coils for high field MRI is still a very dynamic field of investigation and development Temnikov has been recently proposed a new volume coil design, similar to the to the gradiometer coil. It is also claimed that it is possible to individually tune it with a single chip capacitor. This motivated the development of a coil prototype based on this idea for whole-body MRI of rodents at 7 Tesla. Electromagnetic simulations of the RF field generated by this coil design were previously performed to study its properties. Electromagnetic simulations were also conducted for a standard birdcage coil with similar dimensions for fare comparison. In all numerical simulations, an unbalanced currents distribution was assumed by applying half the current intensity to designated legs. This coil design operated in the transceiver mode and was linear-driven. The coil size was manufactured to accommodate small rodents. Numerical simulations showed a field uniformity improvement of our coil over the standard birdcage coil. A popular birdcage coil was also constructed to compare their performances. Phantom and rat images were acquired for both volume coils to prove the viability of this coil design for high field MRI applications and standard spin echo pulse sequences Thus, these preliminary results make this coil design a good candidate for MRI and MRS applications of high magnetic fields.

  9. The conceptual design of a robust, compact, modular tokamak reactor based on high-field superconductors

    NASA Astrophysics Data System (ADS)

    Whyte, D. G.; Bonoli, P.; Barnard, H.; Haakonsen, C.; Hartwig, Z.; Kasten, C.; Palmer, T.; Sung, C.; Sutherland, D.; Bromberg, L.; Mangiarotti, F.; Goh, J.; Sorbom, B.; Sierchio, J.; Ball, J.; Greenwald, M.; Olynyk, G.; Minervini, J.

    2012-10-01

    Two of the greatest challenges to tokamak reactors are 1) large single-unit cost of each reactor's construction and 2) their susceptibility to disruptions from operation at or above operational limits. We present an attractive tokamak reactor design that substantially lessens these issues by exploiting recent advancements in superconductor (SC) tapes allowing peak field on SC coil > 20 Tesla. A R˜3.3 m, B˜9.2 T, ˜ 500 MW fusion power tokamak provides high fusion gain while avoiding all disruptive operating boundaries (no-wall beta, kink, and density limits). Robust steady-state core scenarios are obtained by exploiting the synergy of high field, compact size and ideal efficiency current drive using high-field side launch of Lower Hybrid waves. The design features a completely modular replacement of internal solid components enabled by the demountability of the coils/tapes and the use of an immersion liquid blanket. This modularity opens up the possibility of using the device as a nuclear component test facility.

  10. Development of high-pressure, high-field and multifrequency electron spin resonance system.

    PubMed

    Sakurai, T; Taketani, A; Tomita, T; Okubo, S; Ohta, H; Uwatoko, Y

    2007-06-01

    The electron spin resonance (ESR) system which covers the magnetic field region up to 16 T, the quasicontinuous frequency region from 60 to 700 GHz, the temperature region from 1.8 to 4.2 K, and the hydrostatic pressure region up to 1.1 GPa has been developed. This is the first pulsed high-field and multifrequency ESR system with the pressure region over 1 GPa as far as we know. Transmission ESR spectra under hydrostatic pressure can be obtained by combining a piston-cylinder-type pressure cell and the pulsed magnetic field ESR apparatus. The pressure cell consists of a NiCrAl cylinder and sapphire or zirconia inner parts. The use of sapphire or zirconia as inner parts enables us to observe ESR under pressure because these inner parts have high transmittance for the electromagnetic wave with millimeter and submillimeter wavelengths. We have successfully applied this system for the pressure dependence measurements of an isolated spin system NiSnCl(6)6H(2)O up to 1.1 GPa. It was found that the single ion anisotropy parameter D of this compound strongly depends on pressure. The parameter D is approximately proportional to the pressure up to 0.75 GPa, and the relation between D and the pressure can be used for the pressure calibration of this high-field and high-pressure ESR system.

  11. ADX: a high field, high power density, Advanced Divertor test eXperiment

    NASA Astrophysics Data System (ADS)

    Vieira, R.; Labombard, B.; Marmar, E.; Irby, J.; Shiraiwa, S.; Terry, J.; Wallace, G.; Whyte, D. G.; Wolfe, S.; Wukitch, S.; ADX Team

    2014-10-01

    The MIT PSFC and collaborators are proposing an advanced divertor experiment (ADX) - a tokamak specifically designed to address critical gaps in the world fusion research program on the pathway to FNSF/DEMO. This high field (6.5 tesla, 1.5 MA), high power density (P/S ~ 1.5 MW/m2) facility would utilize Alcator magnet technology to test innovative divertor concepts for next-step DT fusion devices (FNSF, DEMO) at reactor-level boundary plasma pressures and parallel heat flux densities while producing high performance core plasma conditions. The experimental platform would also test advanced lower hybrid current drive (LHCD) and ion-cyclotron range of frequency (ICRF) actuators and wave physics at the plasma densities and magnetic field strengths of a DEMO, with the unique ability to deploy launcher structures both on the low-magnetic-field side and the high-field side - a location where energetic plasma-material interactions can be controlled and wave physics is most favorable for efficient current drive, heating and flow drive. This innovative experiment would perform plasma science and technology R&D necessary to inform the conceptual development and accelerate the readiness-for-deployment of FNSF/DEMO - in a timely manner, on a cost-effective research platform. Supported by DE-FC02-99ER54512.

  12. High Field Pulsed Magnets for Neutron Scattering at the Spallation Neutron Source

    NASA Astrophysics Data System (ADS)

    Granroth, G. E.; Lee, J.; Fogh, E.; Christensen, N. B.; Toft-Petersen, R.; Nojiri, H.

    2015-03-01

    A High Field Pulsed Magnet (HFPM) setup, is in use at the Spallation Nuetron Source(SNS), Oak Ridge National Laboratory. With this device, we recently measured the high field magnetic spin structure of LiNiPO4. The results of this study will be highlighted as an example of possible measurements that can be performed with this device. To further extend the HFPM capabilities at SNS, we have learned to design and wind these coils in house. This contribution will summarize the magnet coil design optimization procedure. Specifically by varying the geometry of the multi-layer coil, we arrive at a design that balances the maximum field strength, neutron scattering angle, and the field homogeneity for a specific set of parameters. We will show that a 6.3kJ capacitor bank, can provide a magnetic field as high as 30T for a maximum scattering angle around 40° with homogeneity of +/- 4 % in a 2mm diameter spherical volume. We will also compare the calculations to measurements from a recently wound test coil. This work was supported in part by the Lab Directors' Research and Development Fund of ORNL.

  13. Numerical simulation of screening current distribution in HTS tape of high field magnet

    NASA Astrophysics Data System (ADS)

    Itoh, Ryusei; Oga, Yuki; Noguchi, So; Igarashi, Hajime; Ueda, Hiroshi

    2013-01-01

    In recent years, properties of high temperature superconducting (HTS) tapes, especially in-field performance and mechanical strength, have been continuously improved. The HTS tapes have been widely used for high field (>20 T) magnet researches and there are several technical challenges including field attenuation of an HTS magnet by screening currents induced within the HTS tapes. Several publications reported that the screening currents, induced by penetration of self magnetic fields into HTS tapes within an HTS magnet, weakened a field constant of the HTS magnet. The result may demonstrate that the screening current changes an overall current density distribution in HTS tapes and, as a consequence, the generated magnetic field. Therefore, it is necessary to investigate the screening current distribution in an HTS tape. This paper reports numerical simulation of the screening current distribution in an HTS tape of high field magnets using 2D finite element method with the E-J characteristic of the HTS tape taken into account. Self magnetic field distribution and its orientation to the HTS tape are also considered to compute critical currents and locally generated electric fields, two key components to figure out the distribution of screening currents.

  14. Widespread inflammation in CLIPPERS syndrome indicated by autopsy and ultra-high-field 7T MRI

    PubMed Central

    Blaabjerg, Morten; Ruprecht, Klemens; Sinnecker, Tim; Kondziella, Daniel; Niendorf, Thoralf; Kerrn-Jespersen, Bjørg Morell; Lindelof, Mette; Lassmann, Hans; Kristensen, Bjarne Winther; Paul, Friedemann

    2016-01-01

    Objective: To examine if there is widespread inflammation in the brain of patients with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) syndrome by using histology and ultra-high-field MRI at 7.0T. Methods: We performed a detailed neuropathologic examination in 4 cases, including 1 autopsy case, and studied 2 additional patients by MRI at 7.0T to examine (1) extension of inflammation to areas appearing normal on 3.0T MRI, (2) potential advantages of 7.0T MRI compared to 3.0T MRI in reflecting widespread inflammation, perivascular pathology, and axonal damage, and (3) the possibility of lymphoma. Results: In the autopsy case, perivascular inflammation dominated by CD4+ T cells was not only detected in the brainstem and cerebellum but also in brain areas with normal appearance on 3.0T MRI, including supratentorial regions and cranial nerve roots. There was no evidence of lymphoma in any of the 4 patients. The 7.0T MRI in clinical remission also revealed supratentorial lesions and perivascular pathology in vivo with contrast-enhancing lesions centered around a small venous vessel. Ultra-high-field MRI at 7.0T disclosed prominent T1 hypointensities in the brainstem, which were not seen on 3.0T MRI. This corresponded to neuropathologic detection of axonal injury in the autopsy case. Conclusion: Our findings suggest more widespread perivascular inflammation and postinflammatory axonal injury in patients with CLIPPERS. PMID:27144217

  15. Scaling of high-field transport and localized heating in graphene transistors.

    PubMed

    Bae, Myung-Ho; Islam, Sharnali; Dorgan, Vincent E; Pop, Eric

    2011-10-25

    We use infrared thermal imaging and electrothermal simulations to find that localized Joule heating in graphene field-effect transistors on SiO(2) is primarily governed by device electrostatics. Hot spots become more localized (i.e., sharper) as the underlying oxide thickness is reduced, such that the average and peak device temperatures scale differently, with significant long-term reliability implications. The average temperature is proportional to oxide thickness, but the peak temperature is minimized at an oxide thickness of ∼90 nm due to competing electrostatic and thermal effects. We also find that careful comparison of high-field transport models with thermal imaging can be used to shed light on velocity saturation effects. The results shed light on optimizing heat dissipation and reliability of graphene devices and interconnects. PMID:21913673

  16. New high homogeneity 55T pulsed magnet for high field NMR.

    PubMed

    Orlova, A; Frings, P; Suleiman, M; Rikken, G L J A

    2016-07-01

    Pulsed magnets can produce magnetic fields largely exceeding those achieved with resistive or even hybrid magnets. This kind of magnet is indispensable in studies of field-induced phenomena which occur only in high magnetic field. A new high homogeneous pulsed magnet capable of producing field up to 55T and specially designed for NMR experiments was built and tested. Experimentally observed homogeneity of magnetic field in central part of the magnet is 10ppm over a sample volume of 2-3mm(3) at 12T and 30ppm at 47T, which are the best values ever reported for a pulsed magnet. Reasons which affect the field profile and reduce homogeneity at high field are discussed. PMID:27179456

  17. Light weight, high field, stable, superconducting magnets for advanced transportation systems

    SciTech Connect

    Lubell, M.S.; Dresner, L.; Kenney, W.J.; Lue, J.W.; Luton, J.N.; Schwenterly, S.W.

    1991-01-01

    Although the Guideway may be the most expensive component of a MAGLEV system, the importance of a suitable magnet system should not be underestimated. The reliability of operation of MAGLEV depends on the superconducting magnets performing to their specifications in a reliable manner (i.e., without training or quenching). Besides reliability the magnets should produce high field, be sufficiently stable to withstand reasonable perturbations, be light weight, be protected in the event of a quench, and be economical (although performance should outweigh cost). We propose to develop superconducting magnets that have these features. Our magnet designs are based on internally cooled, cable-in-conduit superconductor with Polymer Matrix Composites (PMC) as the structural reinforcement. Although the initial work is with metallic superconductors such as NbTi, the processes being developed will be applicable to the High Temperature Ceramic Superconductors when they become suitable for magnet applications.

  18. Harmonic generation at high field strengths - Frequency shifts and saturation phenomena. [optical mixing technique

    NASA Technical Reports Server (NTRS)

    Stappaerts, E. A.

    1975-01-01

    Optical harmonic generation and mixing in the gas phase has been proposed as a technique for the generation of coherent radiation in the vacuum ultraviolet and soft X-ray spectral region. At the high field strengths required by these processes the interaction between atoms and the electromagnetic field shows intensity-dependent resonances. In this paper we modify harmonic generation theory to include the effect of these frequency shifts. Closed-form expressions for generated dipole moment, absorption probability, and coherence length are presented. The most important consequences of frequency shifts on resonantly enhanced processes are that the pump laser must be tuned away from the small-field resonance frequency, that the conversion efficiency may saturate, and that the dispersion of the medium may change sign. As an example, the generation of 198-A radiation by a five-photon mixing process in Li(+) is considered.

  19. Petal Resonator Surface Coil with a Circular Envelope for High Field Magnetic Resonance Imaging

    NASA Astrophysics Data System (ADS)

    Hidalgo, S. S.; Cuellar, G.; Solis, S. E.; Alejski, A.; Rodríguez, A. O.

    2008-08-01

    A modified version of the petal resonator surface (PERES) coil is proposed in which the petal coils are located inside a circular-shaped coil as opposed to the previous PERES version which did not have a circular envelope. An 8-petal coil was simulated using a finite element method and the quasi-static approach to numerically investigate its electromagnetic characteristics. Numerical simulations showed that the field uniformity is not greatly affected by the use of circular-shaped coil inside in the circular envelope. A coil prototype was developed using the same coil configuration as above and tested on a commercial 3 T imager and a General Electric phantom. Phantom images also demonstrated that the mutual inductance between petals does not alter the coil performance. Standard pulse sequences were used to acquire phantom images with the petal resonator surface coil. It was shown that this prototype resonator coil is fully compatible with clinical high field MR imagers and clinical pulse sequences.

  20. The design and construction of high field-uniformity permanent magnet system for MRI

    SciTech Connect

    Feng, Z.X.; Jiang, X.H.; Han, S. )

    1992-01-01

    This paper reports that the permanent magnet system used for MRI has some advantages: the lower cost/field ratio in the range of magnetic field 1.5-3.0 kG; no need power supply and cryogenic equipment. So, the MRI device with a permanent magnet system has marketable value. The MRI device requires a high field-uniformity magnet system. The necessary field-uniformity is better than several tens of ppm in a 30 cm diameter spherical volume. Generally, the shim coils can be used for correcting the magnetic field in working area, but the authors developed a passive method to correct the field-uniformity. First, the specially designed ferromagnetic pole pieces are disposed onto the surfaces of the main permanent magnet poles to improve the field-uniformity preliminarily. Then, the necessary field-uniformity will be obtained by using the magneto-dipoles which are suitably placed in the field domain.

  1. Characterization of Plasma Discharges in a High-Field Magnetic Tandem Mirror

    NASA Technical Reports Server (NTRS)

    Chang-Diaz, Franklin R.

    1998-01-01

    High density magnetized plasma discharges in open-ended geometries, like Tandem Mirrors, have a variety of space applications. Chief among them is the production of variable Specific Impulse (I(sub sp)) and variable thrust in a magnetic nozzle. Our research group is pursuing the experimental characterization of such discharges in our high-field facility located at the Advanced Space Propulsion Laboratory (ASPL). These studies focus on identifying plasma stability criteria as functions of density, temperature and magnetic field strength. Plasma heating is accomplished by both Electron and Ion Cyclotron Resonance (ECR and ICR) at frequencies of 2-3 Ghz and 1-30 Mhz respectively, for both Hydrogen and Helium. Electron density and temperature has measured by movable Langmuir probes. Macroscopic plasma stability is being investigated in ongoing research.

  2. Comparison of oxide leakage currents induced by ion implantation and high field electric stress

    NASA Astrophysics Data System (ADS)

    Goguenheim, D.; Bravaix, A.; Monserie, C.; Moragues, J. M.; Lambert, P.; Boivin, P.

    2001-08-01

    We compare in this work the electrical properties of gate leakage currents induced through the thin SiO2 oxide layer of metal-oxide-semiconductor structures by high-energy ion implantation (Boron B2+) and high field electrical stresses where electrons are injected from the gate in the Fowler-Nordheim regime. Even if the high-frequency capacitance-voltage characteristics are very different after both treatments, comparable increases and similar shapes are found at low field in static gate current-voltage curves, typical of equivalent oxide damage. Moreover, these stress or implantation induced leakage currents are both removed in a similar way by a thermal anneal under forming gas at 430°C. We conclude that similar defects could be induced through the oxide by both processes and generate those excess currents by a defect assisted tunneling mechanism.

  3. High field terahertz emission from relativistic laser-driven plasma wakefields

    SciTech Connect

    Chen, Zi-Yu; Pukhov, Alexander

    2015-10-15

    We propose a method to generate high field terahertz (THz) radiation with peak strength of GV/cm level in the THz frequency gap range of 1–10 THz using a relativistic laser interaction with a gaseous plasma target. Due to the effect of local pump depletion, an initially Gaussian laser pulse undergoes leading edge erosion and eventually evolves to a state with leading edge being step function. Interacting with such a pulse, electrons gain transverse residual momentum and excite net transverse currents modulated by the relativistic plasma frequency. These currents give rise to the low frequency THz emission. We demonstrate this process with one and two dimensional particle-in-cell simulations.

  4. A high-field (30 Tesla) pulsed magnet instrument for single-crystal scattering studies

    NASA Astrophysics Data System (ADS)

    Islam, Zahirul; Nojiri, Hiroyuki; Narumi, Yasuo; Lang, Jonathan

    2010-03-01

    Pulsed magnets have emerged as a viable approach at synchrotron x-ray facilities for studying materials in high magnetic fields. We are developing a new high-field (30 Tesla) pulsed magnet system for single-crystal x-ray diffraction studies. It consists of a single 18mm-bore solenoid, designed and built at Tohoku University using high-tensile-strength and high conductivity CuAg wires. A dual-cryostat scheme has been developed at Advanced Photon Source in order to cool the coil using liquid nitrogen and the sample using a closed-cycle cryostat independently. Liquid nitrogen cooling allows repetition rate of a few minutes for peak fields near 30 Tesla. This scheme is unique in that it allows the applied magnetic field to be parallel to the scattering plane. Time-resolved scattering data are typically collected using a fast one-dimensional strip detector. Opportunities and challenges for experiments and instrumentation will be discussed.

  5. Process for the chemical preparation of high-field ZnO varistors

    DOEpatents

    Brooks, Robert A.; Dosch, Robert G.; Tuttle, Bruce A.

    1987-01-01

    Chemical preparation techniques involving co-precipitation of metals are used to provide micro-structural characteristics necessary in order to produce ZnO varistors and their precursors for high field applications. The varistors produced have homogeneous and/or uniform dopant distributions and a submicron average grain size with a narrow size distribution. Precursor powders are prepared via chemical precipitation techniques and varistors made by sintering uniaxially and/or isostatically pressed pellets. Using these methods, varistors were made which were suitable for high-power applications, having values of breakdown field, E.sub.B, in the 10-100 kV/cm range, .alpha.>30 and densities in the range of 65-99% of theoretical, depending on both composition and sintering temperature.

  6. High-field asymmetric waveform ion mobility spectrometry for mass spectrometry-based proteomics.

    PubMed

    Swearingen, Kristian E; Moritz, Robert L

    2012-10-01

    High-field asymmetric waveform ion mobility spectrometry (FAIMS) is an atmospheric pressure ion mobility technique that separates gas-phase ions by their behavior in strong and weak electric fields. FAIMS is easily interfaced with electrospray ionization and has been implemented as an additional separation mode between liquid chromatography (LC) and mass spectrometry (MS) in proteomic studies. FAIMS separation is orthogonal to both LC and MS and is used as a means of on-line fractionation to improve the detection of peptides in complex samples. FAIMS improves dynamic range and concomitantly the detection limits of ions by filtering out chemical noise. FAIMS can also be used to remove interfering ion species and to select peptide charge states optimal for identification by tandem MS. Here, the authors review recent developments in LC-FAIMS-MS and its application to MS-based proteomics. PMID:23194268

  7. Development of superconducting magnet for high-field MR systems in China

    NASA Astrophysics Data System (ADS)

    Wang, Zanming; van Oort, Johannes M.; Zou, Mark X.

    2012-11-01

    In this paper we describe the development of superconducting magnets for high-field Magnetic Resonance Imaging (MRI) by various businesses and institutions in China. As the Chinese MR market rapidly expands, many foreign and domestic companies and research institutions are joining the race to meet the burgeoning demand by developing key MRI components for various magnetic field configurations. After providing a brief introduction to research on MRI superconducting magnets that dates back to the 1980s, the first large-bore 1.5 T superconducting magnet with 50-cm DSV for whole-body MRI - successfully developed and manufactured by AllTech Medical Systems in Chengdu, China-is presented and its specifications are described.

  8. Fabrication of highly ordered nanoporous alumina films by stable high-field anodization

    NASA Astrophysics Data System (ADS)

    Li, Yanbo; Zheng, Maojun; Ma, Li; Shen, Wenzhong

    2006-10-01

    Stable high-field anodization (1500-4000 A m-2) for the fabrication of highly ordered porous anodic alumina films has been realized in a H3PO4-H2O-C2H5OH system. By maintaining the self-ordering voltage and adjusting the anodizing current density, high-quality self-ordered alumina films with a controllable inter-pore distance over a large range are achieved. The high anodizing current densities lead to high-speed film growth (4-10 µm min-1). The inter-pore distance is not solely dependent on the anodizing voltage, but is also influenced by the anodizing current density. This approach is simple and cost-effective, and is of great value for applications in diverse areas of nanotechnology.

  9. ANALYSIS OF HIGH FIELD NON-LINEAR LOSSES ON SRF SURFACES DUE TO SPECIFIC TOPOGRAPHIC ROUGHNESS

    SciTech Connect

    Chen Xu,Charles Reece,Michael Kelley

    2012-07-01

    The high-field performance of SRF cavities will eventually be limited by the realization of fundamental material limits, whether it is Hc1 or Hsh, or some derivative thereof, at which the superconductivity is lost. Before reaching this fundamental field limit at the macro level, it must be encountered at localized, perhaps microscopic, sites of field enhancement due to local topography. If such sites are small enough, they may produce thermally stabilized normal-conducting regions which contribute non-linear losses when viewed from the macro resonant field perspective, and thus produce degradation in Q0. We have undertaken a calculation of local surface magnetic field enhancement from specific fine topographic structure by conformal mapping method and numerically. A solution of the resulting normal conducting volume has been derived and the corresponding RF Ohmic loss simulated.

  10. An atomistic description of the high-field degradation of dielectric polyethylene

    SciTech Connect

    Bealing, Clive R.; Ramprasad, R.

    2013-11-07

    A microscopic mechanism governing the initiating step in the high-field aging of crystalline polyethylene is proposed, based on density functional calculations and ab initio molecular dynamics simulations. It is assumed that electrons, holes, and excitons are present in the system. While the additional individual electrons or holes are not expected to lead to significant degradation, the presence of triplet excitons are concluded to be rather damaging. The electron and hole states of the exciton localize on a distorted region of polyethylene, significantly weakening nearby C–H bonds and facilitating C–H bond scission. The barrier to cleavage of the weakened C–H bonds is estimated and is comparable to the thermal energy, suggesting that this mechanism may be responsible for the degradation of polyethylene when placed under electrical stress, e.g., in high-voltage cables.

  11. On the nature of high field charge transport in reinforced silicone dielectrics: Experiment and simulation

    NASA Astrophysics Data System (ADS)

    Huang, Yanhui; Schadler, Linda S.

    2016-08-01

    The high field charge injection and transport properties in reinforced silicone dielectrics were investigated by measuring the time-dependent space charge distribution and the current under dc conditions up to the breakdown field and were compared with the properties of other dielectric polymers. It is argued that the energy and spatial distribution of localized electronic states are crucial in determining these properties for polymer dielectrics. Tunneling to localized states likely dominates the charge injection process. A transient transport regime arises due to the relaxation of charge carriers into deep traps at the energy band tails and is successfully verified by a Monte Carlo simulation using the multiple-hopping model. The charge carrier mobility is found to be highly heterogeneous due to the non-uniform trapping. The slow moving electron packet exhibits a negative field dependent drift velocity possibly due to the spatial disorder of traps.

  12. Microstructural understanding and critical current optimization of advanced high field superconductors

    SciTech Connect

    Bonney, L.A.; Willis, T.C.; Larbalestier, D.C.

    1993-01-01

    It is of great importance to improve critical current density, J[sub c] in A15 superconductors for high field magnet applications. Most current work to improve J[sub c] in A15 wires concentrates on increasing the overall J[sub c] by increasing the fraction of superconducting phase in the wire, by improving the uniformity of the superconductor cross section along the length of the wire and by adjusting the strainstate of the A15 layer. The goal of the A15 work in this group was to investigate the intrinsic J[sub c] of the A15 layer itself. To do this, a better understanding of factors controlling the intrinsic J[sub c]of the Nb[sub 3]Sn was pursued.

  13. Atomic Hydrogen as High-Precision Field Standard for High-Field EPR

    PubMed Central

    Stoll, Stefan; Ozarowski, Andrew; Britt, R. David; Angerhofer, Alexander

    2010-01-01

    We introduce atomic hydrogen trapped in an octaisobutylsilsesquioxane nanocage (H@iBuT8) as a new molecular high-precision magnetic field standard for high-field EPR spectroscopy of organic radicals and other systems with signals around g = 2. Its solid-state EPR spectrum consists of two narrow lines separated by about 51 mT and centered at g ≈ 2. The isotropic g factor is 2.00294(3) and essentially temperature independent. The isotopic 1H hyperfine coupling constant is 1416.8(2) MHz below 70 K and decreases slightly with increasing temperature to 1413.7(1) MHz at room temperature. The spectrum of the standard does not overlap with those of most organic radicals, and it can be easily prepared and is stable at room temperature. PMID:20813570

  14. High-field launch electron cyclotron heating experiments in the ELMO Bumpy Torus

    SciTech Connect

    Rasmussen, D.A.; Batchelor, D.B.; Swain, D.W.; White, T.L.; Kimrey, H.D.; Bigelow, T.S.; Cobble, J.A.; Hillis, D.L.; Richards, R.K.; Uckan, T.

    1985-05-01

    The midplane microwave heating system in the ELMO Bumpy Torus (EBT) was supplemented with power launched from the high-field side of the fundamental resonance by an antenna in the magnet coil throat. Up to 43 kW of polarized (extraordinary mode), 28-GHz power was successfully launched with one antenna. Measurements were made of changes in the core and hot electron ring plasma parameters when throat-launch power was added. In sharp contrast to initial expectations, the bulk core plasma parameters were degraded while the ring parameters, in the launch cavity, were improved. These results are explained in light of a modified picture of electron cyclotron heating (ECH) in EBT. A picture of localized microwave absorption and particle losses is supported by additional measurements.

  15. A process for the chemical preparation of high-field ZnO varistors

    DOEpatents

    Brooks, R.A.; Dosch, R.G.; Tuttle, B.A.

    1986-02-19

    Chemical preparation techniques involving co-precipitation of metals are used to provide microstructural characteristics necessary in order to produce ZnO varistors and their precursors for high field applications. The varistors produced have homogeneous and/or uniform dopant distributions and a submicron average grain size with a narrow size distribution. Precursor powders are prepared via chemical precipitation techniques and varistors made by sintering uniaxially and/or isostatically pressed pellets. Using these methods, varistors were made which were suitable for high-power applications, having values of breakdown field, E/sub B/, in the 10 to 100 kV/cm range, ..cap alpha.. > 30 and densities in the range of 65 to 99% of theoretical, depending on both composition and sintering temperature.

  16. Low magnetic moment PIN diodes for high field MRI surface coils.

    PubMed

    Voskoboynik, Pavel; Joos, Ronald D; Doherty, W E; Goldfarb, Ron B

    2006-12-01

    Positive-intrinsic-negative (PIN) silicon diodes are commonly used in magnetic resonance imaging (MRI) coils to perform active or passive blocking and detuning, or to disable circuit functions. However, diode packages with large magnetic moments are known to cause image artifacts in high field MRI systems. In this study, diode packages with low magnetic moment were designed by compensating components of ferromagnetic nickel and paramagnetic tungsten with diamagnetic silver. The new diodes have an initial positive susceptibility up to fields of 1 T and a negative susceptibility from 1 to 7 T. Their magnetic moments are one to two orders of magnitude smaller than those of standard diodes; moments as small as 20 nJ/T at 7 T were achieved. PMID:17278801

  17. Low-field MRI can be more sensitive than high-field MRI

    NASA Astrophysics Data System (ADS)

    Coffey, Aaron M.; Truong, Milton L.; Chekmenev, Eduard Y.

    2013-12-01

    MRI signal-to-noise ratio (SNR) is the key factor for image quality. Conventionally, SNR is proportional to nuclear spin polarization, which scales linearly with magnetic field strength. Yet ever-stronger magnets present numerous technical and financial limitations. Low-field MRI can mitigate these constraints with equivalent SNR from non-equilibrium ‘hyperpolarization' schemes, which increase polarization by orders of magnitude independently of the magnetic field. Here, theory and experimental validation demonstrate that combination of field independent polarization (e.g. hyperpolarization) with frequency optimized MRI detection coils (i.e. multi-turn coils using the maximum allowed conductor length) results in low-field MRI sensitivity approaching and even rivaling that of high-field MRI. Four read-out frequencies were tested using samples with identical numbers of 1H and 13C spins. Experimental SNRs at 0.0475 T were ∼40% of those obtained at 4.7 T. Conservatively, theoretical SNRs at 0.0475 T 1.13-fold higher than those at 4.7 T were possible despite an ∼100-fold lower detection frequency, indicating feasibility of high-sensitivity MRI without technically challenging, expensive high-field magnets. The data at 4.7 T and 0.0475 T was obtained from different spectrometers with different RF probes. The SNR comparison between the two field strengths accounted for many differences in parameters such as system noise figures and variations in the probe detection coils including Q factors and coil diameters.

  18. INTERCOMPARISON OF PERFORMANCE OF RF COIL GEOMETRIES FOR HIGH FIELD MOUSE CARDIAC MRI

    PubMed Central

    Constantinides, Christakis; Angeli, S.; Gkagkarellis, S.; Cofer, G.

    2012-01-01

    Multi-turn spiral surface coils are constructed in flat and cylindrical arrangements and used for high field (7.1 T) mouse cardiac MRI. Their electrical and imaging performances, based on experimental measurements, simulations, and MRI experiments in free space, and under phantom, and animal loading conditions, are compared with a commercially available birdcage coil. Results show that the four-turn cylindrical spiral coil exhibits improved relative SNR (rSNR) performance to the flat coil counterpart, and compares fairly well with a commercially available birdcage coil. Phantom experiments indicate a 50% improvement in the SNR for penetration depths ≤ 6.1 mm from the coil surface compared to the birdcage coil, and an increased penetration depth at the half-maximum field response of 8 mm in the 4-spiral cylindrical coil case, in contrast to 2.9 mm in the flat 4-turn spiral case. Quantitative comparison of the performance of the two spiral coil geometries in anterior, lateral, inferior, and septal regions of the murine heart yield maximum mean percentage rSNR increases of the order of 27–167% in vivo post-mortem (cylindrical compared to flat coil). The commercially available birdcage outperforms the cylindrical spiral coil in rSNR by a factor of 3–5 times. The comprehensive approach and methodology adopted to accurately design, simulate, implement, and test radiofrequency coils of any geometry and type, under any loading conditions, can be generalized for any application of high field mouse cardiac MRI. PMID:23204945

  19. High-field EPR study of carotenoid and chlorophyll cation radicals in photosystem II.

    SciTech Connect

    Lakshmi, K. V.; Reifler, M. J.; Brudvig, G. W.; Poluektov, O. G.; Wagner, A. M.; Thurnuaer, M. C.; Chemistry; Yale Univ.

    2000-11-16

    In photosystem II (PS II), chlorophyll, {beta}-carotene, and cytochrome b{sub 559} are alternate electron donors that may be involved in a photoprotection mechanism. The present study describes the use of high-field EPR spectroscopy to characterize the low-temperature photooxidation of Chl{sub z} and Car cofactors in PS II. The EPR signals of the individual species, previously not resolved at X-band frequency (9 GHz), are resolved at higher D-band frequency (130 GHz) in deuterated Synechococcus lividus PS II. Deuteration of PS II results in significant narrowing of the EPR lines, yielding well-resolved EPR spectra of the Car{sup +} and Chl{sub z}{sup +} radicals at 130 GHz. The g tensors of the individual species were determined by EPR spectral simulations. The g tensor determined for the Car{sup +} radical (g{sub xx} = 2.00335, g{sub yy} = 2.00251, g{sub zz} = 2.00227) is similar to that previously observed for a canthaxanthin cation radical but with a slightly rhombic tensor. The Chl{sub z}{sup +} g tensor (g{sub xx} = 2.00312, g{sub yy} = 2.00263, g{sub zz} = 2.00202) is similar to that of a chlorophyll a cation radical. This study shows that both the carotenoid and chlorophyll radicals are generated in PS II by illumination at temperatures from 6 to 190 K and that there is no interconversion of Car{sup +} and Chl{sub z}{sup +} radicals upon dark annealing at temperatures up to 160 K. This study also establishes the feasibility of using deuteration and high-field EPR to resolve previously unresolvable cofactor signals in PS II.

  20. Low-field MRI can be more sensitive than high-field MRI

    PubMed Central

    Coffey, Aaron M.; Truong, Milton

    2014-01-01

    MRI signal-to-noise ratio (SNR) is the key factor for image quality. Conventionally, SNR is proportional to nuclear spin polarization, which scales linearly with magnetic field strength. Yet ever-stronger magnets present numerous technical and financial limitations. Low-field MRI can mitigate these constraints with equivalent SNR from non-equilibrium ‘hyperpolarization’ schemes, which increase polarization by orders of magnitude independently of the magnetic field. Here, theory and experimental validation demonstrate that combination of field independent polarization (e.g. hyperpolarization) with frequency optimized MRI detection coils (i.e. multi-turn coils using the maximum allowed conductor length) results in low-field MRI sensitivity approaching and even rivaling that of high-field MRI. Four read-out frequencies were tested using samples with identical numbers of 1H and 13C spins. Experimental SNRs at 0.0475 T were ∼40% of those obtained at 4.7 T. Conservatively, theoretical SNRs at 0.0475 T 1.13-fold higher than 4.7 T were possible despite an ∼100-fold lower detection frequency, indicating feasibility of high-sensitivity MRI without technically challenging, expensive high-field magnets. The data at 4.7 T and 0.0475 T was obtained from different spectrometers with different RF probes. The SNR comparison between the two field strengths accounted for many differences in parameters such as system noise figures and variations in the probe detection coils including Q factors and coil diameters. PMID:24239701

  1. Image homogenization using pre-emphasis method for high field MRI

    PubMed Central

    Li, Ye; Wang, Chunsheng; Yu, Baiying; Vigneron, Daniel; Chen, Wei

    2013-01-01

    Radiofrequency (RF) field (B1) inhomogeneity due to shortened wavelength at high field is a major cause of magnetic resonance imaging (MRI) nonuniformity in high dielectric biological samples (e.g., human body). In this work, we propose a method to improve the B1 and MRI homogeneity by using pre-emphasized non-uniform B1 distribution. The intrinsic B1 distribution that could be generated by a RF volume coil, specifically a microstrip transmission line (MTL) coil used in this work, was pre-emphasized in the sample’s periphery region of interest to compensate for the central brightness induced by high frequency interference effect due to shortened wave length. This pre-emphasized non-uniform B1 can be realized by varying the parameters of microstrip elements, such as the substrate thickness of MTL volume coil. Both numerical simulation and phantom MR imaging studies were carried out to investigate the feasibility and merit of the proposed method in achieving homogeneous MR images. The simulation results demonstrate that by using a pre-emphasized B1 distribution generated by the MTL volume coil, relatively uniform B1 distribution and homogeneous MR image (98% homogeneity) within the spherical phantom (15 cm diameter) were achieved with 4.5 mm thickness. The B1 and MRI intensity distributions of a 16-element MTL volume coil with fixed substrate thickness and five varied saline loads were modeled and experimentally tested. Similar results from both simulation and experiments were obtained, suggesting substantial improvements of B1 and MRI homogeneities within the phantom containing 125 mM saline. The overall results demonstrate an efficient B1 shimming approach for improving high field MRI. PMID:24040618

  2. Superconductivity and Critical Current of Iron-Based Superconductors in High Field

    NASA Astrophysics Data System (ADS)

    Li, Qiang

    2014-03-01

    Although high-temperature superconducting cuprates have been discovered for more than 26 years, high-field applications are still based on low-temperature superconductors (LTS), such as Nb3Sn. The high anisotropies, brittle textures and high manufacturing costs limit the applicability of the cuprates. Recently, we demonstrated that the iron superconductors, without most of the drawbacks of the cuprates, have a superior high-field performance over LTS at 4.2 K [Nat. Commun. 4:1347 (2013); Rep. Prog. Phys. 74 124510 (2011)]. In this presentation, I will discuss recent progress aimed at understanding the relationships between superconductivity, critical current, and nano-scaled structure defects in iron-based superconductors, with emphasis on the properties of superconducting iron chalcogenide films. Critical current densities Jc ~ 107 A/cm2 were observed in FeSe0.5Te0.5 films grown on CeO2 buffered single-crystalline and flexible metal substrates. These films are capable of carrying Jc exceeding 105 A/cm2 under 30 T magnetic fields. Furthermore, we found that these films have significantly higher Tc (>20K) as compared to bulk samples (bulk Tc ~ 15 K) for the entire doping regime of FeSe1-xTex. Structural analysis revealed that these films generally have significantly smaller c-axis and a-axis lattice constant than the bulk value, suggesting that the crystal structure changes have a dominating impact on the superconducting transition in iron-based superconductors. Large Jc enhancement can also be realized in iron based superconductors by irradiation with proton and heavy ions that opens a new avenue for a tailored landscape of effective vortex pinning defects.

  3. NMR in High Fields and Field Gradients up to 42 T

    NASA Astrophysics Data System (ADS)

    Sigmund, Eric E.

    2002-03-01

    We describe nuclear magnetic resonance (NMR) experiments performed in fields as high as 42 T. This work was done at Northwestern University and the National High Magnetic Field Laboratory (NHMFL) with superconducting magnets, resistive Bitter-style electromagnets, and a superconducting-resistive hybrid magnet. After reviewing crucial probe and spectrometer design features, we describe the scientific and technical advantages that high field provides for two experiments. First, we studied the mixed state of the high-temperature superconductor YBa_2Cu_3O_7-x through ^17O NMR.[1] The NMR spectrum gives the field distribution associated with vortices which we use to selectively inspect regions inside and outside the vortex core. We use the spin-lattice relaxation rate (T_1-1) to probe the electronic density-of-states in this spatially resolved fashion. Second, we have studied ultraslow diffusion in glass-forming liquids such as glycerol. These studies use the high magnetic field gradient at the edge of the solenoid, which can exceed 200 T/m for the resistive magnets at the NHMFL. We employed a 4 K inductive shield to stabilize the fluctuations in the resistive magnets' applied field over the necessarily long timescales of a slow diffusion NMR experiment. We have also made use of fast frequency jumping to enhance signal-to-noise by circumventing the finite spatial excitation bandwidth imposed by the large gradient. We show NMR experiments of slow diffusion in glass-formers up to high field (H0 = 21 T, G = 220 T/m) that have resolved diffusivities as low as 10-10 cm^2/s. [1] V. F. Mitrovic et.al., Nature 413, 501-504 (2001).

  4. Short period, high field cryogenic undulator for extreme performance x-ray free electron lasers

    NASA Astrophysics Data System (ADS)

    O'Shea, F. H.; Marcus, G.; Rosenzweig, J. B.; Scheer, M.; Bahrdt, J.; Weingartner, R.; Gaupp, A.; Grüner, F.

    2010-07-01

    Short period, high field undulators can enable short wavelength free electron lasers (FELs) at low beam energy, with decreased gain length, thus allowing much more compact and less costly FEL systems. We describe an ongoing initiative to develop such an undulator based on an approach that utilizes novel cryogenic materials. While this effort was begun in the context of extending the photon energy regime of a laser-plasma accelerator based electron source, we consider here implications of its application to sub-fs scenarios in which more conventional injectors are employed. The use of such low-charge, ultrashort beams, which has recently been proposed as a method of obtaining single-spike performance in x-ray FELs, is seen in simulation to give unprecedented beam brightness. This brightness, when considered in tandem with short wavelength, high field undulators, enables extremely high performance FELs. Two examples discussed in this paper illustrate this point well. The first is the use of the SPARX injector at 2.1 GeV with 1 pC of charge to give 8 GW peak power in a single spike at 6.5 Å with a photon beam peak brightness greater than 1035photons/(smm2mrad20.1%BW), which will also reach LCLS wavelengths on the 5th harmonic. The second is the exploitation of the LCLS injector with 0.25 pC, 150 as pulses to lase at 1.5 Å using only 4.5 GeV energy; beyond this possibility, we present start-to-end simulations of lasing at unprecedented short wavelength, 0.15 Å, using 13.65 GeV LCLS design energy.

  5. Magnetic properties of natural and synthetic olivines: high-field measurements

    NASA Astrophysics Data System (ADS)

    Ferre, E. C.; Martin-Hernandez, F.

    2004-12-01

    Olivine [(Fex, Mg1-x)2 SiO4] is an orthosilicate solid solution between fayalite [Fe2 SiO4] and forsterite [Mg2 SiO4]. Olivine is a major constituent of the Earth mantle that is abundant in oceanic and continental peridotites and mantle xenoliths. The magnetic properties of olivines have been previously investigated using gem quality natural crystals known as peridots (Zabargad) or using laboratory grown synthetic crystals. Magnetic investigations are generally performed using low magnetic field or neutron diffraction techniques. Optical microscopy and TEM imagery reveal that most olivine crystals host iron oxides formed by exsolution during cooling. Theoretically, the magnetic susceptibility of olivine should decrease linearly from fayalite to fayalite as a function of the Fe content. The magnetic behavior should range from antiferromagnetic at high Fe content, paramagnetic at intermediate Fe contents and diamagnetic at very low Fe contents. New magnetic measurements, performed on various high field instruments (vibrating sample magnetometer, torque magnetometer, cantilever magnetometer), both on natural and synthetic samples, display ferromagnetic behavior, interpreted as due to the systematic presence of titanomagnetite inclusions in olivine crystals. These results emphasize the need to conduct measurements in high field in order to isolate the intrinsic paramagnetic properties of olivines. These measurements demonstrate the orthorhombic nature of the intrinsic paramagnetic properties, but also yield new data concerning the relationship between crystallographic axes, magnetic anisotropy and other physical anisotropies: [100] = K1, [010] = K2 and [001] = K3. Preliminary results also indicate substantial variations in degree of paramagnetic anisotropy (P) and paramagnetic shape factor (T). For Fo92, P = 1.359 and T = -0.845. These intrinsic paramagnetic properties are used to model the magnetic behavior of olivine across a range of temperatures relevant to

  6. Development and manufacture of a Nb/sub 3/Sn superconductor for the high-field test facility

    SciTech Connect

    Scanlan, R.M.; Cornish, D.N.; Spencer, C.R.; Gregory, E.; Adam, E.

    1981-10-20

    The High-Field Test Facility (HFTF) project has two primary goals. The first is to establish manufacturing capability for a Nb/sub 3/Sn conductor suitable for use in a mirror fusion coil. The second is to provide a test facility for evaluating other fusion conductor designs at high fields. This paper describes some of the problems encountered and the solutions devised in working toward the first goal. Construction of the test facility coils will be described in a subsequent paper.

  7. ADX: a high field, high power density, advanced divertor and RF tokamak

    NASA Astrophysics Data System (ADS)

    LaBombard, B.; Marmar, E.; Irby, J.; Terry, J. L.; Vieira, R.; Wallace, G.; Whyte, D. G.; Wolfe, S.; Wukitch, S.; Baek, S.; Beck, W.; Bonoli, P.; Brunner, D.; Doody, J.; Ellis, R.; Ernst, D.; Fiore, C.; Freidberg, J. P.; Golfinopoulos, T.; Granetz, R.; Greenwald, M.; Hartwig, Z. S.; Hubbard, A.; Hughes, J. W.; Hutchinson, I. H.; Kessel, C.; Kotschenreuther, M.; Leccacorvi, R.; Lin, Y.; Lipschultz, B.; Mahajan, S.; Minervini, J.; Mumgaard, R.; Nygren, R.; Parker, R.; Poli, F.; Porkolab, M.; Reinke, M. L.; Rice, J.; Rognlien, T.; Rowan, W.; Shiraiwa, S.; Terry, D.; Theiler, C.; Titus, P.; Umansky, M.; Valanju, P.; Walk, J.; White, A.; Wilson, J. R.; Wright, G.; Zweben, S. J.

    2015-05-01

    The MIT Plasma Science and Fusion Center and collaborators are proposing a high-performance Advanced Divertor and RF tokamak eXperiment (ADX)—a tokamak specifically designed to address critical gaps in the world fusion research programme on the pathway to next-step devices: fusion nuclear science facility (FNSF), fusion pilot plant (FPP) and/or demonstration power plant (DEMO). This high-field (⩾6.5 T, 1.5 MA), high power density facility (P/S ˜ 1.5 MW m-2) will test innovative divertor ideas, including an ‘X-point target divertor’ concept, at the required performance parameters—reactor-level boundary plasma pressures, magnetic field strengths and parallel heat flux densities entering into the divertor region—while simultaneously producing high-performance core plasma conditions that are prototypical of a reactor: equilibrated and strongly coupled electrons and ions, regimes with low or no torque, and no fuelling from external heating and current drive systems. Equally important, the experimental platform will test innovative concepts for lower hybrid current drive and ion cyclotron range of frequency actuators with the unprecedented ability to deploy launch structures both on the low-magnetic-field side and the high-magnetic-field side—the latter being a location where energetic plasma-material interactions can be controlled and favourable RF wave physics leads to efficient current drive, current profile control, heating and flow drive. This triple combination—advanced divertors, advanced RF actuators, reactor-prototypical core plasma conditions—will enable ADX to explore enhanced core confinement physics, such as made possible by reversed central shear, using only the types of external drive systems that are considered viable for a fusion power plant. Such an integrated demonstration of high-performance core-divertor operation with steady-state sustainment would pave the way towards an attractive pilot plant, as envisioned in the ARC concept

  8. Simultaneous EEG-fMRI at ultra-high field: artifact prevention and safety assessment.

    PubMed

    Jorge, João; Grouiller, Frédéric; Ipek, Özlem; Stoermer, Robert; Michel, Christoph M; Figueiredo, Patrícia; van der Zwaag, Wietske; Gruetter, Rolf

    2015-01-15

    The simultaneous recording of scalp electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) can provide unique insights into the dynamics of human brain function, and the increased functional sensitivity offered by ultra-high field fMRI opens exciting perspectives for the future of this multimodal approach. However, simultaneous recordings are susceptible to various types of artifacts, many of which scale with magnetic field strength and can seriously compromise both EEG and fMRI data quality in recordings above 3T. The aim of the present study was to implement and characterize an optimized setup for simultaneous EEG-fMRI in humans at 7 T. The effects of EEG cable length and geometry for signal transmission between the cap and amplifiers were assessed in a phantom model, with specific attention to noise contributions from the MR scanner coldheads. Cable shortening (down to 12 cm from cap to amplifiers) and bundling effectively reduced environment noise by up to 84% in average power and 91% in inter-channel power variability. Subject safety was assessed and confirmed via numerical simulations of RF power distribution and temperature measurements on a phantom model, building on the limited existing literature at ultra-high field. MRI data degradation effects due to the EEG system were characterized via B0 and B1(+) field mapping on a human volunteer, demonstrating important, although not prohibitive, B1 disruption effects. With the optimized setup, simultaneous EEG-fMRI acquisitions were performed on 5 healthy volunteers undergoing two visual paradigms: an eyes-open/eyes-closed task, and a visual evoked potential (VEP) paradigm using reversing-checkerboard stimulation. EEG data exhibited clear occipital alpha modulation and average VEPs, respectively, with concomitant BOLD signal changes. On a single-trial level, alpha power variations could be observed with relative confidence on all trials; VEP detection was more limited, although

  9. Polarizing agents and mechanisms for high-field dynamic nuclear polarization of frozen dielectric solids.

    PubMed

    Hu, Kan-Nian

    2011-09-01

    This article provides an overview of polarizing mechanisms involved in high-frequency dynamic nuclear polarization (DNP) of frozen biological samples at temperatures maintained using liquid nitrogen, compatible with contemporary magic-angle spinning (MAS) nuclear magnetic resonance (NMR). Typical DNP experiments require unpaired electrons that are usually exogenous in samples via paramagnetic doping with polarizing agents. Thus, the resulting nuclear polarization mechanism depends on the electron and nuclear spin interactions induced by the paramagnetic species. The Overhauser Effect (OE) DNP, which relies on time-dependent spin-spin interactions, is excluded from our discussion due the lack of conducting electrons in frozen aqueous solutions containing biological entities. DNP of particular interest to us relies primarily on time-independent, spin-spin interactions for significant electron-nucleus polarization transfer through mechanisms such as the Solid Effect (SE), the Cross Effect (CE) or Thermal Mixing (TM), involving one, two or multiple electron spins, respectively. Derived from monomeric radicals initially used in high-field DNP experiments, bi- or multiple-radical polarizing agents facilitate CE/TM to generate significant NMR signal enhancements in dielectric solids at low temperatures (<100 K). For example, large DNP enhancements (∼300 times at 5 T) from a biologically compatible biradical, 1-(TEMPO-4-oxy)-3-(TEMPO-4-amino)propan-2-ol (TOTAPOL), have enabled high-resolution MAS NMR in sample systems existing in submicron domains or embedded in larger biomolecular complexes. The scope of this review is focused on recently developed DNP polarizing agents for high-field applications and leads up to future developments per the CE DNP mechanism. Because DNP experiments are feasible with a solid-state microwave source when performed at <20K, nuclear polarization using lower microwave power (<100 mW) is possible by forcing a high proportion of biradicals to

  10. Two high-field thermodynamically stable conductivity states in photoconductive CdS, one n-type and one p-type

    SciTech Connect

    Böer, Karl W.

    2015-08-28

    Photoconductive CdS is known to be n-type and develops high-field domains in the range of negative differential conductivities. These domains have been extensively discussed, and when remaining attached to the electrodes have been renamed Böer domains (a broader definition suggested earlier is misleading) [K. Thiessen, Phys. Status Solidi B 248, 2775 (2011)]. They are occurring at high applied voltage in a range at which the current becomes highly non-ohmic that is conventionally described as N-shaped when the conductance decreases with increasing bias or as S-shaped when the current starts to increase again. In this paper only such cases will be discussed in which the current stays below significant Joule heating (no current channel formation), and only for stationary electrode-attached high-field domains. These are the cathode-attached domains that are maintained by field-quenching and are thermodynamically stable. Their finding is summarized in the first segment of this paper. When the applied voltage is increased, an anode-attached hyper-high-field domain develops that is stabilized by a hole blocking anode and will be analyzed in more detail below. It will be shown that they are a thermodynamically stable p-type photoconductive state of CdS. These two new states can be used to determine the carrier densities and mobilities as function of the field and the effective work function in dependence of the spectral distribution of the optical excitation. In a thin slab adjacent to a blocking cathode, the quasi-Fermi levels are spread to a precise amount and are kept there in the entire high-field region. This opens the opportunity to analyze with small modulation of the excitation the trap transition coefficients near these quasi-Fermi levels separately, without broadening interference from other signals. This has already resulted in the discovery of an unusually sharp electron quenching level when the CdS was in a p-type state with an anode adjacent domain. It is

  11. Two high-field thermodynamically stable conductivity states in photoconductive CdS, one n-type and one p-type

    NASA Astrophysics Data System (ADS)

    Böer, Karl W.

    2015-08-01

    Photoconductive CdS is known to be n-type and develops high-field domains in the range of negative differential conductivities. These domains have been extensively discussed, and when remaining attached to the electrodes have been renamed Böer domains (a broader definition suggested earlier is misleading) [K. Thiessen, Phys. Status Solidi B 248, 2775 (2011)]. They are occurring at high applied voltage in a range at which the current becomes highly non-ohmic that is conventionally described as N-shaped when the conductance decreases with increasing bias or as S-shaped when the current starts to increase again. In this paper only such cases will be discussed in which the current stays below significant Joule heating (no current channel formation), and only for stationary electrode-attached high-field domains. These are the cathode-attached domains that are maintained by field-quenching and are thermodynamically stable. Their finding is summarized in the first segment of this paper. When the applied voltage is increased, an anode-attached hyper-high-field domain develops that is stabilized by a hole blocking anode and will be analyzed in more detail below. It will be shown that they are a thermodynamically stable p-type photoconductive state of CdS. These two new states can be used to determine the carrier densities and mobilities as function of the field and the effective work function in dependence of the spectral distribution of the optical excitation. In a thin slab adjacent to a blocking cathode, the quasi-Fermi levels are spread to a precise amount and are kept there in the entire high-field region. This opens the opportunity to analyze with small modulation of the excitation the trap transition coefficients near these quasi-Fermi levels separately, without broadening interference from other signals. This has already resulted in the discovery of an unusually sharp electron quenching level when the CdS was in a p-type state with an anode adjacent domain. It is

  12. Mass spectrometric characterization of a high-field asymmetric waveform ion mobility spectrometer

    NASA Astrophysics Data System (ADS)

    Purves, Randy W.; Guevremont, Roger; Day, Stephen; Pipich, Charles W.; Matyjaszczyk, Matthew S.

    1998-12-01

    Ion mobility spectrometry (IMS) has become an important method for the detection of many compounds because of its high sensitivity and amenability to miniaturization for field-portable monitoring; applications include detection of narcotics, explosives, and chemical warfare agents. High-field asymmetric waveform ion mobility spectrometry (FAIMS) differs from IMS in that the electric fields are applied using a high-frequency periodic asymmetric waveform, rather than a dc voltage. Furthermore, in FAIMS the compounds are separated by the difference in the mobility of ions at high electric field relative to low field, rather than by compound to compound differences in mobility at low electric field (IMS). We report here the first cylindrical-geometry-FAIMS interface with mass spectrometry (FAIMS-MS) and the MS identification of the peaks observed in a FAIMS compensation voltage (CV) spectrum. Using both an electrometer-based-FAIMS (FAIMS-E) and FAIMS-MS, several variables that affect the sensitivity of ion detection were examined for two (polarity reversed) asymmetric waveforms (modes 1 and 2) each of which yields a unique spectrum. An increase in the dispersion voltage (DV) was found to improve the sensitivity and separation observed in the FAIMS CV spectrum. This increase in sensitivity and the unexpected dissimilarity in modes 1 and 2 suggest that atmospheric pressure ion focusing is occurring in the FAIMS analyzer. The sensitivity and peak locations in the CV spectra were affected by temperature, gas flow rates, operating pressure, and analyte concentration.

  13. Wall scanning probe for high-field side plasma measurements on Alcator C-Mod.

    PubMed

    Smick, Noah; LaBombard, Brian

    2009-02-01

    A new, high-field side scanning probe has been added to Alcator C-Mod's complement of edge diagnostics. The wall scanning probe is designed to provide all the benefits of a linear plunge, multielectrode scanning probe while working from the confined space of the inner tokamak wall. The drive mechanism is an embedded coil which produces a torque with the ambient toroidal magnetic field when energized, thus allowing the probe to plunge to different preprogramed depths at different times during a plasma discharge. The probe tip is designed for easy replacement and is presently configured to operate as a modified, high heat-flux "Gundestrup-type" probe with four tungsten electrodes. The probe has demonstrated the ability to obtain cross-field profiles for electron temperature, density, floating potential, and plasma flow information (parallel and perpendicular to B) up to a depth of a few millimiters inside the last-closed flux surface in standard C-Mod discharges. The tungsten-tipped probe has proved very robust and shows little or no damage though it routinely handles surface heat fluxes on the order of 100 MW/m(2) at peak insertion.

  14. High-Field Dynamic Nuclear Polarization for Solid and Solution Biological NMR

    PubMed Central

    Barnes, A.B.; Paëpe, G. De; van der Wel, P.C.A.; Hu, K.-N.; Joo, C.-G.; Bajaj, V.S.; Mak-Jurkauskas, M.L.; Sirigiri, J.R.; Herzfeld, J.; Temkin, R.J.; Griffin, R.G.

    2008-01-01

    Dynamic nuclear polarization (DNP) results in a substantial nuclear polarization enhancement through a transfer of the magnetization from electrons to nuclei. Recent years have seen considerable progress in the development of DNP experiments directed towards enhancing sensitivity in biological nuclear magnetic resonance (NMR). This review covers the applications, hardware, polarizing agents, and theoretical descriptions that were developed at the Francis Bitter Magnet Laboratory at Massachusetts Institute of Technology for high-field DNP experiments. In frozen dielectrics, the enhanced nuclear polarization developed in the vicinity of the polarizing agent can be efficiently dispersed to the bulk of the sample via 1H spin diffusion. This strategy has been proven effective in polarizing biologically interesting systems, such as nanocrystalline peptides and membrane proteins, without leading to paramagnetic broadening of the NMR signals. Gyrotrons have been used as a source of high-power (5–10 W) microwaves up to 460 GHz as required for the DNP experiments. Other hardware has also been developed allowing in situ microwave irradiation integrated with cryogenic magic-angle-spinning solid-state NMR. Advances in the quantum mechanical treatment are successful in describing the mechanism by which new biradical polarizing agents yield larger enhancements at higher magnetic fields. Finally, pulsed methods and solution experiments should play a prominent role in the future of DNP. PMID:19194532

  15. Sintering behavior of doped ZnO powders for high field varistors

    SciTech Connect

    Ghirlanda, M.

    1990-08-01

    The sintering of ZnO varistor precursor powders, doped with Co, Mn and different concentrations of Bi and Al, is investigated and discussed in relation with sintering models. One purpose of the present study is to provide information valuable for the fabrication of high field varistors. As the fundamental parameter of these electronic components is the breakdown voltage per unit of thickness, which is determined by the number of grain boundaries per linear dimension, the grain size and the sintered density are crucial variables, and the sintering is a central step in the manufacturing of such varistors. Sintering experiments performed at constant heating rate in a loading dilatometer provide data on the densification and creep of the compacted powders. Another goal of the present study is to provide an experimental basis for the interpretation of the evolution of the ratio between densification rate and creep rate in terms of competition between densification and microstructure coarsening. This is accomplished by taking advantage of the variety of sintering behaviors that takes place in the system ZnO-Bi-Al: the comparison of these behaviors allows us to correlate the macroscopic sintering parameters to the evolution of the microstructure. It results that, while in non-doped powders densification and coarsening develop in a balanced way, resulting in the constancy of the ratio between densification rate and creep rate, the effect of the dopants on the sintering kinetics alters such a balance, leading this ratio to vary. 17 figs.

  16. High-Field High-Repetition-Rate Sources for the Coherent THz Control of Matter.

    PubMed

    Green, B; Kovalev, S; Asgekar, V; Geloni, G; Lehnert, U; Golz, T; Kuntzsch, M; Bauer, C; Hauser, J; Voigtlaender, J; Wustmann, B; Koesterke, I; Schwarz, M; Freitag, M; Arnold, A; Teichert, J; Justus, M; Seidel, W; Ilgner, C; Awari, N; Nicoletti, D; Kaiser, S; Laplace, Y; Rajasekaran, S; Zhang, L; Winnerl, S; Schneider, H; Schay, G; Lorincz, I; Rauscher, A A; Radu, I; Mährlein, S; Kim, T H; Lee, J S; Kampfrath, T; Wall, S; Heberle, J; Malnasi-Csizmadia, A; Steiger, A; Müller, A S; Helm, M; Schramm, U; Cowan, T; Michel, P; Cavalleri, A; Fisher, A S; Stojanovic, N; Gensch, M

    2016-01-01

    Ultrashort flashes of THz light with low photon energies of a few meV, but strong electric or magnetic field transients have recently been employed to prepare various fascinating nonequilibrium states in matter. Here we present a new class of sources based on superradiant enhancement of radiation from relativistic electron bunches in a compact electron accelerator that we believe will revolutionize experiments in this field. Our prototype source generates high-field THz pulses at unprecedented quasi-continuous-wave repetition rates up to the MHz regime. We demonstrate parameters that exceed state-of-the-art laser-based sources by more than 2 orders of magnitude. The peak fields and the repetition rates are highly scalable and once fully operational this type of sources will routinely provide 1 MV/cm electric fields and 0.3 T magnetic fields at repetition rates of few 100 kHz. We benchmark the unique properties by performing a resonant coherent THz control experiment with few 10 fs resolution. PMID:26924651

  17. Quantum oscillations of the critical current and high-field superconducting proximity in ballistic graphene

    NASA Astrophysics Data System (ADS)

    Ben Shalom, M.; Zhu, M. J.; Fal'Ko, V. I.; Mishchenko, A.; Kretinin, A. V.; Novoselov, K. S.; Woods, C. R.; Watanabe, K.; Taniguchi, T.; Geim, A. K.; Prance, J. R.

    2016-04-01

    Graphene-based Josephson junctions provide a novel platform for studying the proximity effect due to graphene’s unique electronic spectrum and the possibility to tune junction properties by gate voltage. Here we describe graphene junctions with a mean free path of several micrometres, low contact resistance and large supercurrents. Such devices exhibit pronounced Fabry-Pérot oscillations not only in the normal-state resistance but also in the critical current. The proximity effect is mostly suppressed in magnetic fields below 10 mT, showing the conventional Fraunhofer pattern. Unexpectedly, some proximity survives even in fields higher than 1 T. Superconducting states randomly appear and disappear as a function of field and carrier concentration, and each of them exhibits a supercurrent carrying capacity close to the universal quantum limit. We attribute the high-field Josephson effect to mesoscopic Andreev states that persist near graphene edges. Our work reveals new proximity regimes that can be controlled by quantum confinement and cyclotron motion.

  18. Development of High-Field Permanent Magnetic Circuits for NMRI/MRI and Imaging on Mice.

    PubMed

    Wang, Guangxin; Xie, Huantong; Hou, Shulian; Chen, Wei; Yang, Xiuhong

    2016-01-01

    The high-field permanent magnetic circuits of 1.2 T and 1.5 T with novel magnetic focusing and curved-surface correction are developed. The permanent magnetic circuit comprises a magnetic yoke, main magnetic steel, nonspherical curved-surface magnetic poles, plugging magnetic steel, and side magnetic steel. In this work, a novel shimming method is proposed for the effective correction of base magnetic field (B 0) inhomogeneities, which is based on passive shimming on the telescope aspheric cutting, grinding, and fine processing technology of the nonspherical curved-surface magnetic poles and active shimming adding higher-order gradient coils. Meanwhile, the magnetic resonance imaging dedicated alloy with high-saturation magnetic field induction intensity and high electrical resistivity is developed, and nonspherical curved-surface magnetic poles which are made of the dedicated alloy have very good anti-eddy-current effect. In addition, the large temperature coefficient problem of permanent magnet can be effectively controlled by using a high quality temperature controller and deuterium external locking technique. Combining our patents such as gradient coil, RF coil, and integration computer software, two kinds of small animal Micro-MRI instruments are developed, by which the high quality MRI images of mice were obtained. PMID:27034951

  19. Development and Study of NB3SN Strands and Cables for High-Field Accelerator Magnets

    NASA Astrophysics Data System (ADS)

    Barzi, E.; Andreev, N.; Bossert, M.; Kashikhin, V. V.; Turrioni, D.; Yamada, R.; Zlobin, A. V.

    2010-04-01

    The high performance Nb3Sn strand produced by Oxford Superconducting Technology (OST) with the Restack Rod Process (RRP) and a 127 restack design is the baseline conductor presently used in the Fermilab's accelerator magnet R&D program. The original RRP-127 design was further improved in stability by increasing the Cu thickness between subelements after proving the effectiveness of this method in reducing subelement merging [1-3]. A number of RRP-127 billets of various cross sections (RRP-102/127, RRP-108/127 and RRP-114/127) were produced to optimize the design with respect to strand plastic deformation during cabling. The behavior of these new strands was studied using virgin and deformed strand samples, and compared with that of the RRP-54/61 stack design. A Rutherford cable made of 0.7 mm strands was also produced to be used in high field quadrupoles. This paper describes the RRP-127 strand development, and results of strand and cable analyses.

  20. High-Field High-Repetition-Rate Sources for the Coherent THz Control of Matter

    DOE PAGES

    Green, B.; Kovalev, S.; Asgekar, V.; Geloni, G.; Lehnert, U.; Golz, T.; Kuntzsch, M.; Bauer, C.; Hauser, J.; Voigtlaender, J.; et al

    2016-02-29

    Ultrashort flashes of THz light with low photon energies of a few meV, but strong electric or magnetic field transients have recently been employed to prepare various fascinating nonequilibrium states in matter. Here we present a new class of sources based on superradiant enhancement of radiation from relativistic electron bunches in a compact electron accelerator that we believe will revolutionize experiments in this field. Our prototype source generates high-field THz pulses at unprecedented quasi-continuous-wave repetition rates up to the MHz regime. We demonstrate parameters that exceed state-of-the-art laser-based sources by more than 2 orders of magnitude. The peak fields andmore » the repetition rates are highly scalable and once fully operational this type of sources will routinely provide 1 MV/cm electric fields and 0.3 T magnetic fields at repetition rates of few 100 kHz. In conclusion, we benchmark the unique properties by performing a resonant coherent THz control experiment with few 10 fs resolution.« less

  1. Low-Field and High-Field Characterization of THUNDER Actuators

    NASA Technical Reports Server (NTRS)

    Ounaies, Z.; Mossi, K.; Smith, R.; Bernd, J.; Bushnell, Dennis M. (Technical Monitor)

    2001-01-01

    THUNDER (THin UNimorph DrivER) actuators are pre-stressed piezoelectric devices developed at NASA Langley Research Center (LaRC) that exhibit enhanced strain capabilities. As a result, they are of interest in a variety of aerospace applications. Characterization of their performance as a function of electric field, temperature and frequency is needed in order to optimize their operation. Towards that end, a number of THUNDER devices were obtained from FACE International Co. with a stainless steel substrate varying in thickness from 1 mil to 20 mils. The various devices were evaluated to determine low-field and high-field displacement its well as the polarization hysteresis loops. The thermal stability of these drivers was evaluated by two different methods. First, the samples were thermally cycled under electric field by systematically increasing the maximum temperature from 25 C to 200 C while the displacement was being measured. Second, the samples were isothermally aged at 0 C, 50 C, 100 C. and 150 C in air, and the isothermal decay of the displacement was measured at room temperature as a function of time.

  2. High field nuclear magnetic resonance in transition metal substituted BaFe2As2

    NASA Astrophysics Data System (ADS)

    Garitezi, T. M.; Lesseux, G. G.; Rosa, P. F. S.; Adriano, C.; Reyes, A. P.; Kuhns, P. L.; Pagliuso, P. G.; Urbano, R. R.

    2014-05-01

    We report high field 75As nuclear magnetic resonance (NMR) measurements on Co and Cu substituted BaFe2As2 single crystals displaying same structural/magnetic transition T0≃128 K. From our anisotropy studies in the paramagnetic state, we strikingly found virtually identical quadrupolar splitting and consequently the quadrupole frequency νQ≃2.57(1) MHz for both compounds, despite the claim that each Cu delivers 2 extra 3d electrons in BaFe2As2 compared to Co substitution. These results allow us to conclude that a subtle change in the crystallographic structure, particularly in the Fe-As tetrahedra, must be the most probable tuning parameter to determine T0 in this class of superconductors rather than electronic doping. Furthermore, our NMR data around T0 suggest coexistence of tetragonal/paramagnetic and orthorhombic/antiferromagnetic phases between the structural and the spin density wave magnetic phase transitions, similarly to what was reported for K-doped BaFe2As2 [Urbano et al., Phys. Rev. Lett. 105, 107001 (2010)].

  3. High-Field High-Repetition-Rate Sources for the Coherent THz Control of Matter

    PubMed Central

    Green, B.; Kovalev, S.; Asgekar, V.; Geloni, G.; Lehnert, U.; Golz, T.; Kuntzsch, M.; Bauer, C.; Hauser, J.; Voigtlaender, J.; Wustmann, B.; Koesterke, I.; Schwarz, M.; Freitag, M.; Arnold, A.; Teichert, J.; Justus, M.; Seidel, W.; Ilgner, C.; Awari, N.; Nicoletti, D.; Kaiser, S.; Laplace, Y.; Rajasekaran, S.; Zhang, L.; Winnerl, S.; Schneider, H.; Schay, G.; Lorincz, I.; Rauscher, A. A.; Radu, I.; Mährlein, S.; Kim, T. H.; Lee, J. S.; Kampfrath, T.; Wall, S.; Heberle, J.; Malnasi-Csizmadia, A.; Steiger, A.; Müller, A. S.; Helm, M.; Schramm, U.; Cowan, T.; Michel, P.; Cavalleri, A.; Fisher, A. S.; Stojanovic, N.; Gensch, M.

    2016-01-01

    Ultrashort flashes of THz light with low photon energies of a few meV, but strong electric or magnetic field transients have recently been employed to prepare various fascinating nonequilibrium states in matter. Here we present a new class of sources based on superradiant enhancement of radiation from relativistic electron bunches in a compact electron accelerator that we believe will revolutionize experiments in this field. Our prototype source generates high-field THz pulses at unprecedented quasi-continuous-wave repetition rates up to the MHz regime. We demonstrate parameters that exceed state-of-the-art laser-based sources by more than 2 orders of magnitude. The peak fields and the repetition rates are highly scalable and once fully operational this type of sources will routinely provide 1 MV/cm electric fields and 0.3 T magnetic fields at repetition rates of few 100 kHz. We benchmark the unique properties by performing a resonant coherent THz control experiment with few 10 fs resolution. PMID:26924651

  4. A low-cost, high-field-strength magnetic resonance imaging-compatible actuator.

    PubMed

    Secoli, Riccardo; Robinson, Matthew; Brugnoli, Michele; Rodriguez y Baena, Ferdinando

    2015-03-01

    To perform minimally invasive surgical interventions with the aid of robotic systems within a magnetic resonance imaging scanner offers significant advantages compared to conventional surgery. However, despite the numerous exciting potential applications of this technology, the introduction of magnetic resonance imaging-compatible robotics has been hampered by safety, reliability and cost concerns: the robots should not be attracted by the strong magnetic field of the scanner and should operate reliably in the field without causing distortion to the scan data. Development of non-conventional sensors and/or actuators is thus required to meet these strict operational and safety requirements. These demands commonly result in expensive actuators, which mean that cost effectiveness remains a major challenge for such robotic systems. This work presents a low-cost, high-field-strength magnetic resonance imaging-compatible actuator: a pneumatic stepper motor which is controllable in open loop or closed loop, along with a rotary encoder, both fully manufactured in plastic, which are shown to perform reliably via a set of in vitro trials while generating negligible artifacts when imaged within a standard clinical scanner. PMID:25833997

  5. SAR simulations for high-field MRI: how much detail, effort, and accuracy is needed?

    PubMed

    Wolf, S; Diehl, D; Gebhardt, M; Mallow, J; Speck, O

    2013-04-01

    Accurate prediction of specific absorption rate (SAR) for high field MRI is necessary to best exploit its potential and guarantee safe operation. To reduce the effort (time, complexity) of SAR simulations while maintaining robust results, the minimum requirements for the creation (segmentation, labeling) of human models and methods to reduce the time for SAR calculations for 7 Tesla MR-imaging are evaluated. The geometric extent of the model required for realistic head-simulations and the number of tissue types sufficient to form a reliable but simplified model of the human body are studied. Two models (male and female) of the virtual family are analyzed. Additionally, their position within the head-coil is taken into account. Furthermore, the effects of retuning the coils to different load conditions and the influence of a large bore radiofrequency-shield have been examined. The calculation time for SAR simulations in the head can be reduced by 50% without significant error for smaller model extent and simplified tissue structure outside the coil. Likewise, the model generation can be accelerated by reducing the number of tissue types. Local SAR can vary up to 14% due to position alone. This must be considered and sets a limit for SAR prediction accuracy. All these results are comparable between the two body models tested. PMID:22611018

  6. High Field Magnetization Process of an S{=}1 One-Dimensional Antiferromagnet NENP

    NASA Astrophysics Data System (ADS)

    Goto, Tsuneaki; Katori, Hiroko Aruga; Ajiro, Yoshitami

    1992-11-01

    High field magnetization measurements have been performed for NENP at low temperatures in steady fields up to 12 T and in pulsed fields up to 40 T. The magnetization for both directions parallel and perpendicular to the chain axis is extremely small in low fields and increases abruptly above the critical field Bc//{=}9.8± 0.2 T and Bc\\bot{=}13.1± 0.3 T. This result indicates that the ground state of NENP is nonmagnetic, that is, singlet and becomes magnetic above the critical field due to the crossover between the singlet and magnetic excited states, consistent with Haldane’s prediction. The magnetization data are analyzed on the basis of the Tsvelik theory. The two gaps and the single-ion anisotropy constant are estimated to be E1{=}14.2± 0.3 K, E2{=}26.8± 1.8 K and D≈7 K. Using the values of E1 and E2, the Haldane gap for D{=}0 is evaluated to be EG{=}(0.39± 0.2)|J|. This value is in good agreement with the estimation of the Haldane gap from the Monte Carlo simulation. The Tsvelik theory satisfactorily explains the field dependence of the magnetization for NENP.

  7. Corneal temperature changes induced by high-field-strength MR imaging with a head coil.

    PubMed

    Shellock, F G; Crues, J V

    1988-06-01

    High-field-strength/high-frequency magnetic resonance (MR) imaging systems can cause tissue heating. Since the eye is particularly susceptible to temperature elevations because of its relatively poor blood supply, the authors measured corneal temperatures in 33 patients immediately before and after MR imaging performed with a 1.5-T (64-MHz) imager and a transmit/receive head coil at estimated peak specific absorption rates (SAR) ranging from 2.54 to 3.05 W/kg. There was a statistically (P less than .001) significant increase in the average corneal temperature (32.7 degrees C +/- 0.7 before imaging, 33.2 degrees C +/- 0.5 after). The changes in corneal temperature ranged from 0.0 degrees C to 1.8 degrees C (mean, 0.5 degrees C), and the highest corneal temperature measured after imaging was 34.4 degrees C. In animal models, the eye temperature threshold for radio frequency-induced cataractogenesis is between 41 degrees C and 55 degrees C. The authors conclude that clinical MR imaging with use of a head coil at the SARs studied causes relatively minor increases in corneal temperature that do not appear to pose any thermal hazard to ocular tissue. PMID:3363146

  8. SAR simulations for high-field MRI: how much detail, effort, and accuracy is needed?

    PubMed

    Wolf, S; Diehl, D; Gebhardt, M; Mallow, J; Speck, O

    2013-04-01

    Accurate prediction of specific absorption rate (SAR) for high field MRI is necessary to best exploit its potential and guarantee safe operation. To reduce the effort (time, complexity) of SAR simulations while maintaining robust results, the minimum requirements for the creation (segmentation, labeling) of human models and methods to reduce the time for SAR calculations for 7 Tesla MR-imaging are evaluated. The geometric extent of the model required for realistic head-simulations and the number of tissue types sufficient to form a reliable but simplified model of the human body are studied. Two models (male and female) of the virtual family are analyzed. Additionally, their position within the head-coil is taken into account. Furthermore, the effects of retuning the coils to different load conditions and the influence of a large bore radiofrequency-shield have been examined. The calculation time for SAR simulations in the head can be reduced by 50% without significant error for smaller model extent and simplified tissue structure outside the coil. Likewise, the model generation can be accelerated by reducing the number of tissue types. Local SAR can vary up to 14% due to position alone. This must be considered and sets a limit for SAR prediction accuracy. All these results are comparable between the two body models tested.

  9. Transport Comparisons between ITER-FEAT and Compact High-Field Tokamak Reactors

    NASA Astrophysics Data System (ADS)

    Zhu, Ping; Horton, Wendell; Bateman, Glenn; Kritz, Arnold H.; Porcelli, Franco

    2000-10-01

    The next generation magnetic fusion reactors under active consideration are ITER-FEAT and compact high-field (CHF) tokamaks. These represent two rather different concepts for achieving a burning plasma. We use the BALDUR predictive transport code with the MMM99 transport model and the alternative OHE transport model(Aaron J. Redd, et al.,) Phys. Plasmas 5, (1998) 1369. with ITG and new ETG physics. We simulate the proposed reactor designs and compare their fusion performance parameters. ITER-FEAT is a next step large NBI driven reactor with the goal of achieving Q=10 and thus represents a straightforward scaling of our recent study of the transport in JET and DIIID.(P. Zhu, et al.,) Phys. Plasmas 7 (2000) 2898. Comparisons will be made with CHF reactor designs as well as the original ITER design in order to clarify issues identified in the comparison of these machines types. The off-diagonal turbulent particle pinch will be studied as a key issue in the CHF reactor design simulations.

  10. Ultra-high field parallel imaging of the superior parietal lobule during mental maze solving.

    PubMed

    Jerde, Trenton A; Lewis, Scott M; Goerke, Ute; Gourtzelidis, Pavlos; Tzagarakis, Charidimos; Lynch, Joshua; Moeller, Steen; Van de Moortele, Pierre-François; Adriany, Gregor; Trangle, Jeran; Uğurbil, Kâmil; Georgopoulos, Apostolos P

    2008-06-01

    We used ultra-high field (7 T) fMRI and parallel imaging to scan the superior parietal lobule (SPL) of human subjects as they mentally traversed a maze path in one of four directions (up, down, left, right). A counterbalanced design for maze presentation and a quasi-isotropic voxel (1.46 x 1.46 x 2 mm thick) collection were implemented. Fifty-one percent of single voxels in the SPL were tuned to the direction of the maze path. Tuned voxels were distributed throughout the SPL, bilaterally. A nearest neighbor analysis revealed a "honeycomb" arrangement such that voxels tuned to a particular direction tended to occur in clusters. Three-dimensional (3D) directional clusters were identified in SPL as oriented centroids traversing the cortical depth. There were 13 same-direction clusters per hemisphere containing 22 voxels per cluster, on the average; the mean nearest-neighbor, same-direction intercluster distance was 9.4 mm. These results provide a much finer detail of the directional tuning in SPL, as compared to those obtained previously at 4 T (Gourtzelidis et al. Exp Brain Res 165:273-282, 2005). The more accurate estimates of quantitative clustering parameters in 3D brain space in this study were made possible by the higher signal-to-noise and contrast-to-noise ratios afforded by the higher magnetic field of 7 T as well as the quasi-isotropic design of voxel data collection.

  11. Separation and identification of isomeric glycopeptides by high field asymmetric waveform ion mobility spectrometry.

    PubMed

    Creese, Andrew J; Cooper, Helen J

    2012-03-01

    The analysis of intact glycopeptides by mass spectrometry is challenging due to the numerous possibilities for isomerization, both within the attached glycan and the location of the modification on the peptide backbone. Here, we demonstrate that high field asymmetric wave ion mobility spectrometry (FAIMS), also known as differential ion mobility, is able to separate isomeric O-linked glycopeptides that have identical sequences but differing sites of glycosylation. Two glycopeptides from the glycoprotein mucin 5AC, GT(GalNAc)TPSPVPTTSTTSAP and GTTPSPVPTTST(GalNAc)TSAP (where GalNAc is O-linked N-acetylgalactosamine), were shown to coelute following reversed-phase liquid chromatography. However, FAIMS analysis of the glycopeptides revealed that the compensation voltage ranges in which the peptides were transmitted differed. Thus, it is possible at certain compensation voltages to completely separate the glycopeptides. Separation of the glycopeptides was confirmed by unique reporter ions produced by supplemental activation electron transfer dissociation mass spectrometry. These fragments also enable localization of the site of glycosylation. The results suggest that glycan position plays a key role in determining gas-phase glycopeptide structure and have implications for the application of FAIMS in glycoproteomics.

  12. New vertical cryostat for the high field superconducting magnet test station at CERN

    SciTech Connect

    Vande Craen, A.; Atieh, S.; Bajko, M.; Benda, V.; Rijk, G. de; Favre, G.; Giloux, C.; Minginette, P.; Parma, V.; Perret, P.; Pirotte, O.; Ramos, D.; Viret, P.; Hanzelka, P.

    2014-01-29

    In the framework of the R and D program for new superconducting magnets for the Large Hadron Collider accelerator upgrades, CERN is building a new vertical test station to test high field superconducting magnets of unprecedented large size. This facility will allow testing of magnets by vertical insertion in a pressurized liquid helium bath, cooled to a controlled temperature between 4.2 K and 1.9 K. The dimensions of the cryostat will allow testing magnets of up to 2.5 m in length with a maximum diameter of 1.5 m and a mass of 15 tons. To allow for a faster insertion and removal of the magnets and reducing the risk of helium leaks, all cryogenics supply lines are foreseen to remain permanently connected to the cryostat. A specifically designed 100 W heat exchanger is integrated in the cryostat helium vessel for a controlled cooling of the magnet from 4.2 K down to 1.9 K in a 3 m{sup 3} helium bath. This paper describes the cryostat and its main functions, focusing on features specifically developed for this project. The status of the construction and the plans for assembly and installation at CERN are also presented.

  13. Development of High-Field Permanent Magnetic Circuits for NMRI/MRI and Imaging on Mice

    PubMed Central

    Wang, Guangxin; Xie, Huantong; Hou, Shulian; Chen, Wei; Yang, Xiuhong

    2016-01-01

    The high-field permanent magnetic circuits of 1.2 T and 1.5 T with novel magnetic focusing and curved-surface correction are developed. The permanent magnetic circuit comprises a magnetic yoke, main magnetic steel, nonspherical curved-surface magnetic poles, plugging magnetic steel, and side magnetic steel. In this work, a novel shimming method is proposed for the effective correction of base magnetic field (B0) inhomogeneities, which is based on passive shimming on the telescope aspheric cutting, grinding, and fine processing technology of the nonspherical curved-surface magnetic poles and active shimming adding higher-order gradient coils. Meanwhile, the magnetic resonance imaging dedicated alloy with high-saturation magnetic field induction intensity and high electrical resistivity is developed, and nonspherical curved-surface magnetic poles which are made of the dedicated alloy have very good anti-eddy-current effect. In addition, the large temperature coefficient problem of permanent magnet can be effectively controlled by using a high quality temperature controller and deuterium external locking technique. Combining our patents such as gradient coil, RF coil, and integration computer software, two kinds of small animal Micro-MRI instruments are developed, by which the high quality MRI images of mice were obtained. PMID:27034951

  14. SEMI-AUTOMATIC SEGMENTATION OF BRAIN SUBCORTICAL STRUCTURES FROM HIGH-FIELD MRI

    PubMed Central

    Kim, Jinyoung; Lenglet, Christophe; Sapiro, Guillermo; Harel, Noam

    2015-01-01

    Volumetric segmentation of subcortical structures such as the basal ganglia and thalamus is necessary for non-invasive diagnosis and neurosurgery planning. This is a challenging problem due in part to limited boundary information between structures, similar intensity profiles across the different structures, and low contrast data. This paper presents a semi-automatic segmentation system exploiting the superior image quality of ultra-high field (7 Tesla) MRI. The proposed approach handles and exploits multiple structural MRI modalities. It uniquely combines T1-weighted (T1W), T2-weighted (T2W), diffusion, and susceptibility-weighted (SWI) MRI and introduces a dedicated new edge indicator function. In addition to this, we employ prior shape and configuration knowledge of the subcortical structures in order to guide the evolution of geometric active surfaces. Neighboring structures are segmented iteratively, constraining over-segmentation at their borders with a non-overlapping penalty. Extensive experiments with data acquired on a 7T MRI scanner demonstrate the feasibility and power of the approach for the segmentation of basal ganglia components critical for neurosurgery applications such as deep brain stimulation. PMID:25192576

  15. Development of high-pressure and high-field ESR system using SQUID magnetometer.

    PubMed

    Sakurai, T; Fujimoto, K; Goto, R; Okubo, S; Ohta, H; Uwatoko, Y

    2012-10-01

    We have developed a high-pressure and high-field electron spin resonance (ESR) system using the combination of a commercially available superconducting quantum interference device (SQUID) magnetometer and a clamp-type piston cylinder pressure cell. The magnetic field range is up to 5 T, and the maximum pressure reaches 1.5 GPa. The most characteristic feature of this system is its easy handling as compared with other high-pressure ESR systems. Moreover, the macroscopic magnetization measurement can be performed simultaneously with the microscopic ESR measurement. In addition to these features, the well-established pressure calibration method utilizing the change of superconducting transition temperature of tin can be applied to this system. By using this system, we obtained pressure dependence of the single ion magnetic anisotropy parameter D of NiSnCl(6)·6H(2)O up to 1.5 GPa precisely, and the magnetization behavior of this material under pressure was explained well by its pressure dependence of the D value.

  16. Pioneering Structural Solutions for Compact High Field Experiments Developed for the Alcator and the Ignitor Programs

    NASA Astrophysics Data System (ADS)

    Salvetti, M.; Coppi, B.

    2015-11-01

    Recently there has been an increased awareness of the fact that the line of research based on compact high field machines is the most promising to approach ignition conditions in DT burning plasmas and has acquired new perspectives for its applications. Then the technological solutions that have made these machines possible have become subject to new attention and, in some cases, to rediscovery. The Alcator Program and, followed by Ignitor Program, has led to invent the coupled air-core former poloidal field system that has made compact machine possible and has been adopted on all advanced toroidal machines that came after Alcator. A recently rediscovered solution aimed at reducing the mechanical stresses in the inner legs of the toroidal magnet coils is the ``Upper and Lower Bracing Rings'' system that has had a key role in the design of the Ignitor machine and its evolution. Another solution to minimize the machine dimensions while maintaining high toroidal fields, in order to achieve high plasma current densities, is that of ``bucking and wedging'' of the toroidal magnet by coupling it mechanically to the central solenoid. Sponsored in part by the U.S. DoE.

  17. Influence of electrode geometry on the high-field characteristics of photoconductive silicon wafers

    SciTech Connect

    Madangarli, V.P.; Gradinaru, G.; Korony, G.; Sudarshan, T.S.; Loubriel, G.M.; Zutavern, F.J.; Patterson, P.E.

    1994-07-01

    A series of experiment were conducted to study the influence of electrode geometry on the prebreakdown (and breakdown) characteristics of high resistivity ({rho} > 30 k{Omega}-cm), p-type Si wafers under quasi-uniform and non-uniform electric field configurations. In the quasi-uniform field configuration, the 1mm thick Si wafer was mounted between the slots of two plane parallel stainless steel disc electrodes (parallel), while the non-uniform field was obtained by mounting the wafer between two pillar-type electrodes with a hemispherical tip (pillar). The main objective of the above investigation was to verify if the uniform field configuration under a parallel system has a positive influence by reducing the field enhancement at the contact region, as opposed to the definite field enhancement present in the case of the non-uniform pillar system. Also, it was proposed to study the effect of the contact profile on the field distribution over the wafer surface and hence its influence on the high-field performance of the Si wafers.

  18. High-field Zeeman and Paschen-Back effects at high pressure in oriented ruby

    NASA Astrophysics Data System (ADS)

    Millot, Marius; Broto, Jean-Marc; Gonzalez, Jesus

    2008-10-01

    High-field Zeeman and Paschen-Back effects have been observed in single crystals of ruby submitted to hydrostatic pressure up to 10 GPa. A specific setup with a miniature diamond-anvil cell has been developed to combine high pressure and pulsed magnetic fields and to perform magnetophotoluminescence measurements. Careful analysis of low-temperature (4.2 and 77 K) photoluminescence spectra with a 56 T magnetic field applied along the c axis allows for the rectification of the assignment of observed emission lines to corresponding Zeeman-split levels. Besides, the intrinsic Zeeman-splitting factors of excited states reveal a linear pressure-induced increase. This enhancement is a signature of an increase in trigonal distortion induced by hydrostatic pressure. Moreover, spectra with magnetic field perpendicular to crystallographic c axis exhibit a Paschen-Back effect reflecting the progressive alignment of Cr3+ ions spin along the applied field. However, no pressure modification is observed in this compound, contrarily to the Heisenberg-to-Ising spin character pressure-induced transition observed in alexandrite.

  19. Direct Observation of Ion Exchange in Mechanically Activated LiH+MgB2 System Using Ultra-High Field Nuclear Magnetic Resonance Spectroscopy

    SciTech Connect

    Hu, Jian Z.; Kwak, Ja Hun; Yang, Zhenguo; Wan, Xiufeng; Shaw, Leonard D.

    2009-04-06

    The LiBH4 + MgH2 system has great potential for hydrogen vehicle applications. In this study, the reported solid-state hydrogenation system made of LiH + 1/2MgB2 has been investigated using ultra-high field nuclear magnetic resonance spectroscopy. It is found that Mg-Li ion exchange occurs within MgB2 during ball milling to form a compound of (Mg1-xLi2x)B2 which facilitates the formation of LiBH4 in the subsequent hydriding reaction. This discovery offers a scientific foundation for investigating the detailed mechanisms of solid-state hydrogenation and dehdrogenation of the LiBH4 +MgH2 system in the future.

  20. Cost Effective Open Geometry HTS MRI System amended to BSCCO 2212 Wire for High Field Magnets

    SciTech Connect

    Kennth Marken

    2006-08-11

    the project start and that date a substantial shift in the MRI marketplace occurred, with rapid growth for systems at higher fields (1.5 T and above) and a consequent decline in the low field market (<1.0 T). While the project aim appeared technically attainable at that time, the conclusion was reached that the system and market economics do not warrant additional investment. The program was redirected to develop BSCCO 2212 multifilament wire development for high field superconducting magnets for NMR and other scientific research upon an agreement between DOE and Oxford Instruments, Superconducting Technology. The work t took place between September, 2004 and the project end in early 2006 was focused on 2212 multifilamentary wire. This report summarizes the technical achievements both in 2212 dip coated for an HTS MRI system and in BSCCO 2212 multifilamentary wire for high field magnets.

  1. Integration of ultra-high field MRI and histology for connectome based research of brain disorders

    PubMed Central

    Yang, Shan; Yang, Zhengyi; Fischer, Karin; Zhong, Kai; Stadler, Jörg; Godenschweger, Frank; Steiner, Johann; Heinze, Hans-Jochen; Bernstein, Hans-Gert; Bogerts, Bernhard; Mawrin, Christian; Reutens, David C.; Speck, Oliver; Walter, Martin

    2013-01-01

    Ultra-high field magnetic resonance imaging (MRI) became increasingly relevant for in vivo neuroscientific research because of improved spatial resolutions. However, this is still the unchallenged domain of histological studies, which long played an important role in the investigation of neuropsychiatric disorders. While the field of biological psychiatry strongly advanced on macroscopic levels, current developments are rediscovering the richness of immunohistological information when attempting a multi-level systematic approach to brain function and dysfunction. For most studies, histology sections lost information on three-dimensional reconstructions. Translating histological sections to 3D-volumes would thus not only allow for multi-stain and multi-subject alignment in post mortem data, but also provide a crucial step in big data initiatives involving the network analyses currently performed with in vivo MRI. We therefore investigated potential pitfalls during integration of MR and histological information where no additional blockface information is available. We demonstrated that strengths and requirements from both methods can be effectively combined at a spatial resolution of 200 μm. However, the success of this approach is heavily dependent on choices of hardware, sequence and reconstruction. We provide a fully automated pipeline that optimizes histological 3D reconstructions, providing a potentially powerful solution not only for primary human post mortem research institutions in neuropsychiatric research, but also to help alleviate the massive workloads in neuroanatomical atlas initiatives. We further demonstrate (for the first time) the feasibility and quality of ultra-high spatial resolution (150 μm isotopic) imaging of the entire human brain MRI at 7T, offering new opportunities for analyses on MR-derived information. PMID:24098272

  2. Generation and evaluation of an ultra-high-field atlas with applications in DBS planning

    NASA Astrophysics Data System (ADS)

    Wang, Brian T.; Poirier, Stefan; Guo, Ting; Parrent, Andrew G.; Peters, Terry M.; Khan, Ali R.

    2016-03-01

    Purpose Deep brain stimulation (DBS) is a common treatment for Parkinson's disease (PD) and involves the use of brain atlases or intrinsic landmarks to estimate the location of target deep brain structures, such as the subthalamic nucleus (STN) and the globus pallidus pars interna (GPi). However, these structures can be difficult to localize with conventional clinical magnetic resonance imaging (MRI), and thus targeting can be prone to error. Ultra-high-field imaging at 7T has the ability to clearly resolve these structures and thus atlases built with these data have the potential to improve targeting accuracy. Methods T1 and T2-weighted images of 12 healthy control subjects were acquired using a 7T MR scanner. These images were then used with groupwise registration to generate an unbiased average template with T1w and T2w contrast. Deep brain structures were manually labelled in each subject by two raters and rater reliability was assessed. We compared the use of this unbiased atlas with two other methods of atlas-based segmentation (single-template and multi-template) for subthalamic nucleus (STN) segmentation on 7T MRI data. We also applied this atlas to clinical DBS data acquired at 1.5T to evaluate its efficacy for DBS target localization as compared to using a standard atlas. Results The unbiased templates provide superb detail of subcortical structures. Through one-way ANOVA tests, the unbiased template is significantly (p <0.05) more accurate than a single-template in atlas-based segmentation and DBS target localization tasks. Conclusion The generated unbiased averaged templates provide better visualization of deep brain nuclei and an increase in accuracy over single-template and lower field strength atlases.

  3. High field FT-ICR mass spectrometry for molecular characterization of snow board from Moscow regions.

    PubMed

    Mazur, Dmitry M; Harir, Mourad; Schmitt-Kopplin, Philippe; Polyakova, Olga V; Lebedev, Albert T

    2016-07-01

    High field Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry analysis of eight snow samples from Moscow city allowed us to identify more than 2000 various elemental compositions corresponding to regional air pollutants. The hierarchical cluster analysis (HCA) of the data showed good concordance of three main groups of samples with the main wind directions. The North-West group (A1) is represented by several homologous CHOS series of aliphatic organic aerosols. They may form as a result of enhanced photochemical reactions including oxidation of hydrocarbons with sulfonations due to higher amount of SO2 emissions in the atmosphere in this region. Group A2, corresponding to the South-East part of Moscow, contains large amount of oxidized hydrocarbons of different sources that may form during oxidation in atmosphere. These hydrocarbons appear correlated to emissions from traffic, neighboring oil refinery, and power plants. Another family of compounds specific for this region involves CHNO substances formed during oxidation processes including NOx and NO3 radical since emissions of NOx are higher in this part of the city. Group A3 is rich in CHO type of compounds with high H/C and low O/C ratios, which is characteristic of oxidized hydrocarbon-like organic aerosol. CHNO types of compounds in A3 group are probably nitro derivatives of condensed hydrocarbons such as PAH. This non-targeted profiling revealed site specific distribution of pollutants and gives a chance to develop new strategies in air quality control and further studies of Moscow environment. PMID:26994789

  4. High-field MRI and mercury release from dental amalgam fillings.

    PubMed

    Mortazavi, S M J; Neghab, M; Anoosheh, S M H; Bahaeddini, N; Mortazavi, G; Neghab, P; Rajaeifard, A

    2014-04-01

    Mercury is among the most toxic nonradioactive elements which may cause toxicity even at low doses. Some studies showed release of mercury from dental amalgam fillings in individuals who used mobile phone. This study was conducted to assess the effect of high-field MRI on mercury release from dental amalgam filling. We studied two groups of students with identical tooth decays requiring a similar pattern of restorative dentistry. They were exposed to a magnetic flux density of 1.5 T produced by a MRI machine. 16 otherwise healthy students with identical dental decay participated in this study. They underwent similar restorative dentistry procedures and randomly divided into two groups of MRI-exposed and control arms. Urinary concentrations of mercury in the control subjects were measured before (hour 0) and 48 and 72 hrs after amalgam restoration, using cold vapor atomic absorption spectrometry. Urinary concentrations of mercury in exposed individuals were determined before (hour 0), and 24, 48, 72 and 96 hrs after amalgam restoration. Unlike control subjects, they underwent conventional brain MRI (15 min, 99 slices), 24 hrs after amalgam restoration. The mean±SD urinary mercury levels in MRI-exposed individuals increased linearly from a baseline value of 20.70±17.96 to 24.83±22.91 μg/L 72 hrs after MRI. In the control group, the concentration decreased linearly from 20.70±19.77 to 16.14±20.05 μg/L. The difference between urinary mercury in the exposed and control group, 72 hrs after MRI (96 h after restoration),was significant (p=0.046). These findings provide further support for the noxious effect of MRI (exposure to strong magnetic field)and release of mercury from dental amalgam fillings.

  5. High field FT-ICR mass spectrometry for molecular characterization of snow board from Moscow regions.

    PubMed

    Mazur, Dmitry M; Harir, Mourad; Schmitt-Kopplin, Philippe; Polyakova, Olga V; Lebedev, Albert T

    2016-07-01

    High field Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry analysis of eight snow samples from Moscow city allowed us to identify more than 2000 various elemental compositions corresponding to regional air pollutants. The hierarchical cluster analysis (HCA) of the data showed good concordance of three main groups of samples with the main wind directions. The North-West group (A1) is represented by several homologous CHOS series of aliphatic organic aerosols. They may form as a result of enhanced photochemical reactions including oxidation of hydrocarbons with sulfonations due to higher amount of SO2 emissions in the atmosphere in this region. Group A2, corresponding to the South-East part of Moscow, contains large amount of oxidized hydrocarbons of different sources that may form during oxidation in atmosphere. These hydrocarbons appear correlated to emissions from traffic, neighboring oil refinery, and power plants. Another family of compounds specific for this region involves CHNO substances formed during oxidation processes including NOx and NO3 radical since emissions of NOx are higher in this part of the city. Group A3 is rich in CHO type of compounds with high H/C and low O/C ratios, which is characteristic of oxidized hydrocarbon-like organic aerosol. CHNO types of compounds in A3 group are probably nitro derivatives of condensed hydrocarbons such as PAH. This non-targeted profiling revealed site specific distribution of pollutants and gives a chance to develop new strategies in air quality control and further studies of Moscow environment.

  6. Early knee changes in dancers identified by ultra-high-field 7 T MRI.

    PubMed

    Chang, G; Diamond, M; Nevsky, G; Regatte, R R; Weiss, D S

    2014-08-01

    We aimed to determine whether a unique, ultra-high-field 7 T magnetic resonance imaging (MRI) scanner could detect occult cartilage and meniscal injuries in asymptomatic female dancers. This study had Institutional Review Board approval. We recruited eight pre-professional female dancers and nine non-athletic, female controls. We scanned the dominant knee on a 7 T MRI scanner using a three-dimensional fast low-angle shot sequence and a proton density, fast spin-echo sequence to evaluate cartilage and menisci, respectively. Two radiologists scored cartilage (International Cartilage Repair Society classification) and meniscal (Stoller classification) lesions. We applied two-tailed z- and t-tests to determine statistical significance. There were no cartilage lesions in dancers or controls. For the medial meniscus, the dancers demonstrated higher mean MRI score (2.38 ± 0.61 vs 1.0 ± 0.97, P < 0.0001) and higher frequency of mean grade 2 lesions (88% vs 11%, P < 0.01) compared with the controls. For the lateral meniscus, there was no difference in score (0.5 ± 0.81 vs 0.5 ± 0.78, P = 0.78) in dancers compared with the control groups. Asymptomatic dancers demonstrate occult medial meniscal lesions. Because this has been described in early osteoarthritis, close surveillance of dancers' knee symptoms and function with appropriate activity modification may help maintain their long-term knee health.

  7. Feasibility study of Nb3Al Rutherford cable for high field accelerator magnet application

    SciTech Connect

    Yamada, R.; Kikuchi, A.; Ambrosio, G.; Andreev, N.; Barzi, E.; Cooper, C.; Feher, S.; Kashikhin, V.V.; Lamm, M.; Novitski, I.; Takeuchi, T.; Tartaglia, M.; Turrioni, D.; Verweij, A.P.; Wake, M.; Willering, G; Zlobin, A.V.; /Fermilab

    2006-08-01

    Feasibility study of Cu stabilized Nb{sub 3}Al strand and Rutherford cable for the application to high field accelerator magnets are being done at Fermilab in collaboration with NIMS. The Nb{sub 3}Al strand, which was developed and manufactured at NIMS in Japan, has a non-copper Jc of about 844 A/mm{sup 2} at 15 Tesla at 4.2 K, a copper content of 50%, and filament size of about 50 microns. Rutherford cables with 27 Nb{sub 3}Al strands of 1.03 mm diameter were fabricated and tested. Quench tests on a short cable were done to study its stability with only its self field, utilizing a high current transformer. A pair of 2 meter long Nb{sub 3}Al cables was tested extensively at CERN at 4.3 and 1.9 K up to 11 Tesla including its self field with a high transport current of 20.2 kA. In the low field test we observed instability near splices and in the central region. This is related to the flux-jump like behavior, because of excessive amount of Nb in the Nb{sub 3}Al strand. There is possibility that the Nb in Nb{sub 3}Al can cause instability below 2 Tesla field regions. We need further investigation on this problem. Above 8 Tesla, we observed quenches near the critical surface at fast ramp rate from 1000 to 3000 A/sec, with quench velocity over 100 m/sec. A small racetrack magnet was made using a 14 m of Rutherford cable and successfully tested up to 21.8 kA, corresponding to 8.7 T.

  8. High-Field Functional Imaging of Pitch Processing in Auditory Cortex of the Cat.

    PubMed

    Butler, Blake E; Hall, Amee J; Lomber, Stephen G

    2015-01-01

    The perception of pitch is a widely studied and hotly debated topic in human hearing. Many of these studies combine functional imaging techniques with stimuli designed to disambiguate the percept of pitch from frequency information present in the stimulus. While useful in identifying potential "pitch centres" in cortex, the existence of truly pitch-responsive neurons requires single neuron-level measures that can only be undertaken in animal models. While a number of animals have been shown to be sensitive to pitch, few studies have addressed the location of cortical generators of pitch percepts in non-human models. The current study uses high-field functional magnetic resonance imaging (fMRI) of the feline brain in an attempt to identify regions of cortex that show increased activity in response to pitch-evoking stimuli. Cats were presented with iterated rippled noise (IRN) stimuli, narrowband noise stimuli with the same spectral profile but no perceivable pitch, and a processed IRN stimulus in which phase components were randomized to preserve slowly changing modulations in the absence of pitch (IRNo). Pitch-related activity was not observed to occur in either primary auditory cortex (A1) or the anterior auditory field (AAF) which comprise the core auditory cortex in cats. Rather, cortical areas surrounding the posterior ectosylvian sulcus responded preferentially to the IRN stimulus when compared to narrowband noise, with group analyses revealing bilateral activity centred in the posterior auditory field (PAF). This study demonstrates that fMRI is useful for identifying pitch-related processing in cat cortex, and identifies cortical areas that warrant further investigation. Moreover, we have taken the first steps in identifying a useful animal model for the study of pitch perception. PMID:26225563

  9. Studies of high-field sections of a muon helical cooling channel with coil separation

    SciTech Connect

    Lopes, M.L.; Kashikhin, V.S.; Yonehara, K.; Yu, M.; Zlobin, A.V.; /Fermilab

    2011-03-01

    The Helical Cooling Channel (HCC) was proposed for 6D cooling of muon beams required for muon collider and some other applications. HCC uses a continuous absorber inside superconducting magnets which produce solenoidal field superimposed with transverse helical dipole and helical gradient fields. HCC is usually divided into several sections each with progressively stronger fields, smaller aperture and shorter helix period to achieve the optimal muon cooling rate. This paper presents the design issues of the high field section of HCC with coil separation. The effect of coil spacing on the longitudinal and transverse field components is presented and its impact on the muon cooling discussed. The paper also describes methods for field corrections and their practical limits. The magnetic performance of the helical solenoid with coil separation was discussed in this work. The separation could be done in three different ways and the performances could be very different which is important and should be carefully described during the beam cooling simulations. The design that is currently being considered is the one that has the poorest magnetic performance because it presents ripples in all three components, in particular in the helical gradient which could be quite large. Moreover, the average gradient could be off, which could affect the cooling performance. This work summarized methods to tune the gradient regarding the average value and the ripple. The coil longitudinal thickness and the helix period can be used to tune G. Thinner coils tend to reduce the ripples and also bring G to its target value. However, this technique reduces dramatically the operational margin. Wider coils can also reduce the ripple (not as much as thinner coils) and also tune the gradient to its target value. Longer helix periods reduce ripple and correct the gradient to the target value.

  10. High-field magnetic resonance imaging of brain iron: birth of a biomarker?

    PubMed

    Schenck, John F; Zimmerman, Earl A

    2004-11-01

    The brain has an unusually high concentration of iron, which is distributed in an unusual pattern unlike that in any other organ. The physiological role of this iron and the reasons for this pattern of distribution are not yet understood. There is increasing evidence that several neurodegenerative diseases are associated with altered brain iron metabolism. Understanding these dysmetabolic conditions may provide important information for their diagnosis and treatment. For many years the iron distribution in the human brain could be studied effectively only under postmortem conditions. This situation was changed dramatically by the finding that T2-weighted MR imaging at high field strength (initially 1.5 T) appears to demonstrate the pattern of iron distribution in normal brains and that this imaging technique can detect changes in brain iron concentrations associated with disease states. Up to the present time this imaging capability has been utilized in many research applications but it has not yet been widely applied in the routine diagnosis and management of neurodegenerative disorders. However, recent advances in the basic science of brain iron metabolism, the clinical understanding of neurodegenerative diseases and in MRI technology, particularly in the availability of clinical scanners operating at the higher field strength of 3 T, suggest that iron-dependent MR imaging may soon provide biomarkers capable of characterizing the presence and progression of important neurological disorders. Such biomarkers may be of crucial assistance in the development and utilization of effective new therapies for Alzheimer's and Parkinson's diseases, multiple sclerosis and other iron-related CNS disorders which are difficult to diagnose and treat.

  11. CCD Washington photometry of three highly field star contaminated open clusters in the third Galactic quadrant

    NASA Astrophysics Data System (ADS)

    Piatti, A. E.; Clariá, J. J.; Parisi, M. C.; Ahumada, A. V.

    2009-01-01

    We present CCD photometry in the Washington system C and T1 passbands down to T1 ˜ 19.5 magnitudes in the fields of Czernik 26, Czernik 30, and Haffner 11, three poorly studied open clusters located in the third Galactic quadrant. We measured T1 magnitudes and C - T1 colors for a total of 6472 stars distributed throughout cluster areas of 13.6' × 13.6' each. Cluster radii were estimated from star counts in appropriate-sized boxes distributed throughout the entire observed fields. Based on the best fits of isochrones computed by the Padova group to the ( C - T1, T1) color-magnitude diagrams (CMDs), we derived color excesses, heliocentric distances and ages for the three clusters. These are characterized by a relatively small angular size and by a high field star contamination. We performed a firm analysis of the field star contamination of the CMDs and examined different relationships between the position in the Galaxy of known open clusters located within 1 kpc around the three studied ones, their age and their interstellar visual absorption. We confirm previous results in the sense that the closer the cluster birthplace to the Galactic plane, the higher the interstellar visual absorption. We also found that the space velocity dispersion perpendicular to the Galactic plane diminishes as the clusters are younger. The positions, interstellar visual absorptions, ages, and metallicities of the three studied clusters favor the hypothesis that they were not born in the recently discovered Canis major (CMa) dwarf galaxy before it was accreted by the Milky Way.

  12. Magnetic quantum tunneling: key insights from multi-dimensional high-field EPR.

    PubMed

    Lawrence, J; Yang, E-C; Hendrickson, D N; Hill, S

    2009-08-21

    Multi-dimensional high-field/frequency electron paramagnetic resonance (HFEPR) spectroscopy is performed on single-crystals of the high-symmetry spin S = 4 tetranuclear single-molecule magnet (SMM) [Ni(hmp)(dmb)Cl](4), where hmp(-) is the anion of 2-hydroxymethylpyridine and dmb is 3,3-dimethyl-1-butanol. Measurements performed as a function of the applied magnetic field strength and its orientation within the hard-plane reveal the four-fold behavior associated with the fourth order transverse zero-field splitting (ZFS) interaction, (1/2)B(S + S), within the framework of a rigid spin approximation (with S = 4). This ZFS interaction mixes the m(s) = +/-4 ground states in second order of perturbation, generating a sizeable (12 MHz) tunnel splitting, which explains the fast magnetic quantum tunneling in this SMM. Meanwhile, multi-frequency measurements performed with the field parallel to the easy-axis reveal HFEPR transitions associated with excited spin multiplets (S < 4). Analysis of the temperature dependence of the intensities of these transitions enables determination of the isotropic Heisenberg exchange constant, J = -6.0 cm(-1), which couples the four spin s = 1 Ni(II) ions within the cluster, as well as a characterization of the ZFS within excited states. The combined experimental studies support recent work indicating that the fourth order anisotropy associated with the S = 4 state originates from second order ZFS interactions associated with the individual Ni(II) centers, but only as a result of higher-order processes that occur via S-mixing between the ground state and higher-lying (S < 4) spin multiplets. We argue that this S-mixing plays an important role in the low-temperature quantum dynamics associated with many other well known SMMs.

  13. Onset of Superconductivity in YBCO in Very High Fields from ^17O and ^63Cu NMR

    NASA Astrophysics Data System (ADS)

    Halperin, William

    2000-03-01

    We have used NMR to study the onset of superconductivity in near optimally doped YBCO in fields from 1 to 27 T. We have compared Knight shift(^17O), spin-spin relaxation measurements(^17O), and spin lattice relaxation measurements (^63Cu and ^17O). The measurements have been performed as a function of temperature above and below the transition region. The Knight shift can be measured with considerable precision directly giving the Pauli spin susceptibility. We show that the onset of superconductivity in a magnetic field is really a crossover region from normal state behavior to a vortex liquid for which we determine a H-T phase diagram up to high field. The relaxation measurements show clear evidence for the opening of a pseudo gap near 100 K in the transition region. The different NMR experiments are sensitive to the susceptibility dependence on wave vector from different regions of the Brillouin zone indicating possible origins of such a gap including superconducting fluctuations or a gap in the spin excitation spectrum. Magnetic field dependence of the data allows discrimination. Intercomparison between samples near optimal doping as well as the work from other laboratories will be made. This work was performed in collaboration with V. F. Mitović, H. N. Bachman, E. E. Sigmund, M. Eschrig, J. A. Sauls, A. P. Reyes, P. Kuhns, and W. G. Moulton. Work at Northwestern University is supported by the NSF (DMR 91-20000) through the Science and Technology Center for Superconductivity. The NHMFL is supported through the NSF and the state of Florida.

  14. Flux pinning study of RE barium coper oxide coated conductors for high field magnet applications

    NASA Astrophysics Data System (ADS)

    Xu, Aixia

    REBa2Cu3O7-δ (REBCO, RE = rare earth) coated conductor (CC) holds great promise for high field magnet applications owing to its strong irreversibility field (Hirr), low electromagnetic anisotropy (γ2), and high critical current density (Jc). The work of this thesis is tightly related to the development of the funded 32 T, all-superconducting magnet project at the NHMFL. My concern is thus for understanding the optimizing of the working parameters of REBCO CC at low temperatures T, and very high magnetic fields H, focusing on how to enhance Ic and to reduce its angular dependence. Increasing the active cross-section is a direct and economical strategy to enhance the current-carrying capability for REBCO coated conductors. Unfortunately, the high Jc in thin REBCO layers is seldom sustained in thick layers because of difficulties of thick film growth control. In the presence of strong 3D (pin separation far less than film thickness) pins, a high and thickness-independent (Jc) should result. One of major tasks of this thesis is to explore what are the effective strong 3D pins that develop a high and thickness-independent Jc. High and weak thickness-dependent Jc at 77 K is obtained on most recent coated conductors, and BZO nanorods and RE2O 3 nanoparticles are identified as strong 3D pins contributing to this respectable Jc performance. At 77 K, we found that the strong pinning of BZO nanorods remains at least up to 9 T, whereas the strong pinning of RE2O3 nanoparticles gradually evolves to weak collective pinning as the irreversibility field is approached. The second principal part of this thesis concentrates on understanding and minimizing the angular dependence of Jc. Our study is based on the following procedure. First, we investigated the angular dependence of Jc (Jc(θ)) in the working condition of the future 32 T all-superconducting magnet, i.e. 4.2 K and high magnetic field up to 31 T. Our work shows that the low temperature Jc(θ) is Ginzburg-Landau-like at

  15. Tunable High-Field Magnetization in Strongly Exchange-Coupled Freestanding Co/CoO Core/Shell Coaxial Nanowires.

    PubMed

    Salazar-Alvarez, German; Geshev, Julian; Agramunt-Puig, Sebastià; Navau, Carles; Sanchez, Alvaro; Sort, Jordi; Nogués, Josep

    2016-08-31

    The exchange bias properties of Co/CoO coaxial core/shell nanowires were investigated with cooling and applied fields perpendicular to the wire axis. This configuration leads to unexpected exchange-bias effects. First, the magnetization value at high fields is found to depend on the field-cooling conditions. This effect arises from the competition between the magnetic anisotropy and the Zeeman energies for cooling fields perpendicular to the wire axis. This allows imprinting predefined magnetization states to the antiferromagnetic (AFM) shell, as corroborated by micromagnetic simulations. Second, the system exhibits a high-field magnetic irreversibility, leading to open hysteresis loops attributed to the AFM easy axis reorientation during the reversal (effect similar to athermal training). A distinct way to manipulate the high-field magnetization in exchange-biased systems, beyond the archetypical effects, was thus experimentally and theoretically demonstrated. PMID:27502034

  16. The effects of composition, temperature and sample size on the sintering of chem-prep high field varistors.

    SciTech Connect

    Garino, Terry J.

    2007-09-01

    The sintering behavior of Sandia chem-prep high field varistor materials was studied using techniques including in situ shrinkage measurements, optical and scanning electron microscopy and x-ray diffraction. A thorough literature review of phase behavior, sintering and microstructure in Bi{sub 2}O{sub 3}-ZnO varistor systems is included. The effects of Bi{sub 2}O{sub 3} content (from 0.25 to 0.56 mol%) and of sodium doping level (0 to 600 ppm) on the isothermal densification kinetics was determined between 650 and 825 C. At {ge} 750 C samples with {ge}0.41 mol% Bi{sub 2}O{sub 3} have very similar densification kinetics, whereas samples with {le}0.33 mol% begin to densify only after a period of hours at low temperatures. The effect of the sodium content was greatest at {approx}700 C for standard 0.56 mol% Bi{sub 2}O{sub 3} and was greater in samples with 0.30 mol% Bi{sub 2}O{sub 3} than for those with 0.56 mol%. Sintering experiments on samples of differing size and shape found that densification decreases and mass loss increases with increasing surface area to volume ratio. However, these two effects have different causes: the enhancement in densification as samples increase in size appears to be caused by a low oxygen internal atmosphere that develops whereas the mass loss is due to the evaporation of bismuth oxide. In situ XRD experiments showed that the bismuth is initially present as an oxycarbonate that transforms to metastable {beta}-Bi{sub 2}O{sub 3} by 400 C. At {approx}650 C, coincident with the onset of densification, the cubic binary phase, Bi{sub 38}ZnO{sub 58} forms and remains stable to >800 C, indicating that a eutectic liquid does not form during normal varistor sintering ({approx}730 C). Finally, the formation and morphology of bismuth oxide phase regions that form on the varistors surfaces during slow cooling were studied.

  17. High strength kiloampere Bi2Sr2CaCu2Ox cables for high-field magnet applications

    NASA Astrophysics Data System (ADS)

    Shen, Tengming; Li, Pei; Jiang, Jianyi; Cooley, Lance; Tompkins, John; McRae, Dustin; Walsh, Robert

    2015-06-01

    INCONEL X750 for various high-field magnet applications.

  18. High field strength (4.7T) magnetic resonance imaging of hydrocephalus in an African Grey parrot (Psittacus erithacus).

    PubMed

    Fleming, Gregory J; Lester, Nola V; Stevenson, Rhoda; Silver, Xeve S

    2003-01-01

    Hydrocephalus was diagnosed in a juvenile African Grey parrot by high-field strength (4.7-Tesla) magnetic resonance imaging (MRI). Excellent anatomic detail was achieved, and there was severe dilation of all ventricles. Relative obstruction was localized to the level of or beyond the outflow of the fourth ventricle. There have been several reports of hydrocephalus diagnosed postmortem in psittacines (i.e., hook-billed parrots), however, this is the first report of an antemortem diagnosis in a psittacine using high-field strength MRI.

  19. Ultra-high field NMR studies of antibody binding and site-specific phosphorylation of {alpha}-synuclein

    SciTech Connect

    Sasakawa, Hiroaki |; Sakata, Eri; Yamaguchi, Yoshiki; Masuda, Masami |; Mori, Tetsuya; Kurimoto, Eiji; Iguchi, Takeshi; Hisanaga, Shin-ichi; Iwatsubo, Takeshi; Hasegawa, Masato; Kato, Koichi |

    2007-11-23

    Although biological importance of intrinsically disordered proteins is becoming recognized, NMR analyses of this class of proteins remain as tasks with more challenge because of poor chemical shift dispersion. It is expected that ultra-high field NMR spectroscopy offers improved resolution to cope with this difficulty. Here, we report an ultra-high field NMR study of {alpha}-synuclein, an intrinsically disordered protein identified as the major component of the Lewy bodies. Based on NMR spectral data collected at a 920 MHz proton frequency, we performed epitope mapping of an anti-{alpha}-synuclein monoclonal antibody, and furthermore, characterized conformational effects of phosphorylation at Ser129 of {alpha}-synuclein.

  20. 2D/3D quench simulation using ANSYS for epoxy impregnated Nb3Sn high field magnets

    SciTech Connect

    Ryuji Yamada et al.

    2002-09-19

    A quench program using ANSYS is developed for the high field collider magnet for three-dimensional analysis. Its computational procedure is explained. The quench program is applied to a one meter Nb{sub 3}Sn high field model magnet, which is epoxy impregnated. The quench simulation program is used to estimate the temperature and mechanical stress inside the coil as well as over the whole magnet. It is concluded that for the one meter magnet with the presented cross section and configuration, the thermal effects due to the quench is tolerable. But we need much more quench study and improvements in the design for longer magnets.

  1. High field side launch of RF waves: A new approach to reactor actuators

    NASA Astrophysics Data System (ADS)

    Wallace, G. M.; Baek, S. G.; Bonoli, P. T.; Faust, I. C.; LaBombard, B. L.; Lin, Y.; Mumgaard, R. T.; Parker, R. R.; Shiraiwa, S.; Vieira, R.; Whyte, D. G.; Wukitch, S. J.

    2015-12-01

    Launching radio frequency (RF) waves from the high field side (HFS) of a tokamak offers significant advantages over low field side (LFS) launch with respect to both wave physics and plasma material interactions (PMI). For lower hybrid (LH) waves, the higher magnetic field opens the window between wave accessibility (n∥≡c k∥/ω >√{1 -ωpi 2/ω2+ωpe 2/ωce 2 }+ωp e/|ωc e| ) and the condition for strong electron Landau damping (n∥˜√{30 /Te } with Te in keV), allowing LH waves from the HFS to penetrate into the core of a burning plasma, while waves launched from the LFS are restricted to the periphery of the plasma. The lower n∥ of waves absorbed at higher Te yields a higher current drive efficiency as well. In the ion cyclotron range of frequencies (ICRF), HFS launch allows for direct access to the mode conversion layer where mode converted waves absorb strongly on thermal electrons and ions, thus avoiding the generation of energetic minority ion tails. The absence of turbulent heat and particle fluxes on the HFS, particularly in double null configuration, makes it the ideal location to minimize PMI damage to the antenna structure. The quiescent SOL also eliminates the need to couple LH waves across a long distance to the separatrix, as the antenna can be located close to plasma without risking damage to the structure. Improved impurity screening on the HFS will help eliminate the long-standing issues of high Z impurity accumulation with ICRF. Looking toward a fusion reactor, the HFS is the only possible location for a plasma-facing RF antenna that will survive long-term. By integrating the antenna into the blanket module it is possible to improve the tritium breeding ratio compared with an antenna occupying an equatorial port plug. Blanket modules will require remote handling of numerous cooling pipes and electrical connections, and the addition of transmission lines will not substantially increase the level of complexity. The obvious engineering

  2. The high field strength element budget of atmospheric aerosols (puy de Dôme, France)

    NASA Astrophysics Data System (ADS)

    Vlastelic, Ivan; Suchorski, Krzysztof; Sellegri, Karine; Colomb, Aurélie; Nauret, François; Bouvier, Laetitia; Piro, Jean-Luc

    2015-10-01

    High field strength elements (HFSE), including Zr, Hf, Nb, Ta and Ti have low solubility in aqueous fluids and partition into dense and resistant minerals. HFSE proved useful in studying terrestrial weathering and sediment transport, but little is known about their behavior during atmospheric processes, which play an important role in global sedimentary cycles. The atmospheric budget of HFSE is evaluated from the sequential dissolution of aerosol samples collected between 2011 and 2014 at puy de Dôme (1465 m elevation, French Massif Central). Aerosols were sampled during nighttime, while the site is generally located above the planetary boundary layer. Systematic, partial recovery of HFSE during gentle dissolution of aerosols indicates that resistant minerals are ubiquitous in air samples. Total dissolution of aerosols in pressure vessels reveals that Zr and Hf occur on average in sub-crustal abundance, which is consistent with the sampling site being dominantly influenced by oceanic air masses depleted in zircons. Conversely, zircon excess occasionally occurs in continental air masses, in particular those originating from northern Africa. Overall, the Hf/Nd ratio, a proxy for zircon fractionation, varies from 0.26 to 3.94 times the Upper Continental Crust (UCC) value, encompassing the range of worldwide loess. This wide compositional range is consistent with (1) the occurrence of coarse zircons (10-30 μm) in dust source, with possible local enrichments relative to bulk UCC in residual wind-winnowed soils, and (2) gravitational settling of coarse zircons during long-distance (>ca. 1000 km) transport. Niobium and Ta are systematically more abundant (by a mean factor of ∼3) in puy de Dôme aerosols than expected from average crustal or soil concentrations. The volume-weighted average Nb/Ta ratio of 15.5 ± 2.6 (1σ) is also higher than in bulk UCC (11.4-13.3). The positive Nb-Ta anomaly of free troposphere aerosols unlikely reflects a net Nb-Ta enrichment but

  3. Electromagnetic modeling of REBCO high field coils by the H-formulation

    NASA Astrophysics Data System (ADS)

    Xia, Jing; Bai, Hongyu; Lu, Jun; Gavrilin, Andrew V.; Zhou, Youhe; Weijers, Hubertus W.

    2015-12-01

    electromagnetic behavior and ac losses in REBCO high field coils. It also provides a basis to analyze the mechanical characteristics in the coils in the future.

  4. High-field FT-ICR-MS and aromaticity equivalent approach for structural identification of water soluble organic compounds (WSOC)

    NASA Astrophysics Data System (ADS)

    Harir, Mourad; Yassine, Mahmoud M.; Dabek-Zlotorzynska, Ewa; Hertkorn, Norbert; Schmitt-Kopplin, Philippe

    2015-04-01

    Organic aerosol (OA) makes up a large and often dominant fraction, (20 to 90%) of the submicron atmospheric particulate mass, and its effects are becoming increasingly important in determining climatic and health effects of atmospheric aerosols. Despite the abundance of OA, our understanding of the sources, formation processes and atmospheric properties of OA is limited. Atmospheric OA has both primary (directly emitted) and secondary (formed in the atmosphere from precursor gases) sources, which can be natural (e.g. vegetation) and/or anthropogenic (e.g. fossil-based vehicle exhaust or biomass burning). A significant fraction of OA contains as much as 20-70% of water soluble organic compounds (WSOC). The WSOC fraction is a very complex mixture of low volatility, polyfunctional aliphatic and aromatic compounds containing carboxyl, alcohol, carbonyl, sulfo, nitro, and other functionalities. This high degree of chemical complexity of atmospheric organics has inspired a number of sophisticated approaches that are capable of identifying and detecting a variety of different analytes in OA. Accordingly, one of the most challenging areas of atmospheric particulate matter (PM) analysis is to comprehend the molecular complexity of the OA, especially WSOC fraction, a significant component of atmospheric fine PM (PM2.5). The sources of WSOC are not well understood, especially the relative contributions of primary vs. secondary organic aerosol. Therefore, the molecular characterization of WSOC is important because it allows gaining insight into aerosol sources and underlying mechanisms of secondary organic aerosols (SOA) formation and transformation. In this abstract, molecular characterization of WSOC was achieved using high-field mass spectrometry FT-ICR-MS and aromaticity equivalent approach. Aromaticity equivalent (Xc), defined recently as a new parameter calculated from the assigned molecular formulas (complementary to the aromaticity index [1]), is introduced to improve

  5. High field Q slope and the baking effect: Review of recent experimental results and new data on Nb heat treatments

    DOE PAGES

    G. Ciovati; Myneni, G.; Stevie, F.; Maheshwari, P.; Griffis, D.

    2010-02-22

    Here, the performance of superconducting radio-frequency (SRF) cavities made of bulk Nb at high fields (peak surface magnetic field greater than about 90 mT) is characterized by exponentially increasing rf losses (high-field Q-slope), in the absence of field emission, which are often mitigated by low temperature (100-140 °C, 12-48 h) baking. In this contribution, recent experimental results and phenomenological models to explain this effect will be briefly reviewed. New experimental results on the high-field Q-slope will be presented for cavities that had been heat treated in a vacuum furnace at high temperature without subsequent chemical etching. These studies are aimedmore » at understanding the role of hydrogen on the high-field Q-slope and at the passivation of the Nb surface during heat treatment. Improvement of the cavity performances, particularly of the cavities’ quality factor, have been obtained following the high temperature heat-treatments, while SIMS surface analysis measurements on Nb samples treated with the cavities revealed significantly lower hydrogen concentration than for samples that followed standard cavity treatments.« less

  6. The issues and tentative solutions for contrast-enhanced magnetic resonance imaging at ultra-high field strength.

    PubMed

    Fries, Peter; Morelli, John N; Lux, Francois; Tillement, Olivier; Schneider, Günther; Buecker, Arno

    2014-01-01

    Magnetic resonance imaging (MRI) performed at ultra-high field strengths beyond 3 Tesla (T) has become increasingly prevalent in research and preclinical applications. As such, the inevitable clinical implementation of such systems lies on the horizon. The major benefit of ultra-high field MRI is the markedly increased signal-to-noise ratios achievable, enabling acquisition of MR images with simultaneously greater spatial and temporal resolution. However, at field strengths higher than 3 T, the efficacy of Gd(III)-based contrast agents is diminished due to decreased r1 relaxivity, somewhat limiting imaging of the vasculature and contrast-enhanced imaging of tumors. There have been extensive efforts to design new contrast agents with high r1 relaxivities based on macromolecular compounds or nanoparticles; however, the efficacy of these agents at ultra-high field strengths has not yet been proven. The aim of this review article is to provide an overview of the basic principles of MR contrast enhancement processes and to highlight the main factors influencing relaxivity. In addition, challenges and opportunities for contrast-enhanced MRI at ultra-high field strengths will be explored. Various approaches for the development of effective contrast agent molecules that are suitable for a broad spectrum of applied field strengths will be discussed in the context of the current literature.

  7. High field Q slope and the baking effect: Review of recent experimental results and new data on Nb heat treatments

    SciTech Connect

    G. Ciovati, G. Myneni, F. Stevie, P. Maheshwari, D. Griffis

    2010-02-01

    The performance of superconducting radio-frequency (SRF) cavities made of bulk Nb at high fields (peak surface magnetic field greater than about 90 mT) is characterized by exponentially increasing rf losses (high-field Q slope), in the absence of field emission, which are often mitigated by low-temperature (100–140°C, 12–48 h) baking. In this contribution, recent experimental results and phenomenological models to explain this effect will be briefly reviewed. New experimental results on the high-field Q slope will be presented for cavities that had been heat treated in a vacuum furnace at high temperature without subsequent chemical etching. These studies are aimed at understanding the role of hydrogen on the high-field Q slope and at the passivation of the Nb surface during heat treatment. Improvement of the cavity performances, particularly of the cavities’ quality factor, have been obtained following the high-temperature heat treatments, while secondary ion mass spectroscopy surface analysis measurements on Nb samples treated with the cavities revealed significantly lower hydrogen concentration than for samples that followed standard cavity treatments.

  8. High field Q slope and the baking effect: Review of recent experimental results and new data on Nb heat treatments

    SciTech Connect

    G. Ciovati; Myneni, G.; Stevie, F.; Maheshwari, P.; Griffis, D.

    2010-02-22

    Here, the performance of superconducting radio-frequency (SRF) cavities made of bulk Nb at high fields (peak surface magnetic field greater than about 90 mT) is characterized by exponentially increasing rf losses (high-field Q-slope), in the absence of field emission, which are often mitigated by low temperature (100-140 °C, 12-48 h) baking. In this contribution, recent experimental results and phenomenological models to explain this effect will be briefly reviewed. New experimental results on the high-field Q-slope will be presented for cavities that had been heat treated in a vacuum furnace at high temperature without subsequent chemical etching. These studies are aimed at understanding the role of hydrogen on the high-field Q-slope and at the passivation of the Nb surface during heat treatment. Improvement of the cavity performances, particularly of the cavities’ quality factor, have been obtained following the high temperature heat-treatments, while SIMS surface analysis measurements on Nb samples treated with the cavities revealed significantly lower hydrogen concentration than for samples that followed standard cavity treatments.

  9. Relationship between single-file diffusion of mixed and pure gases in dipeptide nanochannels by high field diffusion NMR.

    PubMed

    Dutta, Akshita R; Sekar, Poorvajan; Dvoyashkin, Muslim; Bowers, Clifford R; Ziegler, Kirk J; Vasenkov, Sergey

    2015-09-01

    High field NMR diffusometry reveals single-file diffusion of CO/CH4 mixture in dipeptide nanochannels with a coincident mobility for CO and CH4. In contrast to the relationship commonly observed for normal diffusion, this mixture mobility is only slightly smaller than that of pure CO which diffuses much faster than pure CH4.

  10. Short-lived charge-transfer excitons in organic photovoltaic cells studied by high-field magneto-photocurrent.

    PubMed

    Devir-Wolfman, Ayeleth H; Khachatryan, Bagrat; Gautam, Bhoj R; Tzabary, Lior; Keren, Amit; Tessler, Nir; Vardeny, Z Valy; Ehrenfreund, Eitan

    2014-07-29

    The main route of charge photogeneration in efficient organic photovoltaic cells based on bulk hetero-junction donor-acceptor blends involves short-lived charge-transfer excitons at the donor-acceptor interfaces. The cell efficiency is critically affected by the charge-transfer exciton recombination and dissociation processes. By measuring the magneto-photocurrent under ambient conditions at room temperature, we show here that magnetic field-induced spin-mixing among the charge-transfer exciton spin sublevels occurs in fields up to at least 8.5 Tesla. The resulting magneto-photocurrent increases at high fields showing non-saturating behaviour up to the highest applied field. We attribute the observed high-field spin-mixing mechanism to the difference in the donor-acceptor g-factors. The non-saturating magneto-photocurrent response at high field indicates that there exist charge-transfer excitons with lifetime in the sub-nanosecond time domain. The non-Lorentzian high-field magneto-photocurrent response indicates a dispersive decay mechanism that originates due to a broad distribution of charge-transfer exciton lifetimes.

  11. Mineralogic reservoirs for high-field strength elements in deeply subducted continental sediments

    NASA Astrophysics Data System (ADS)

    Rapp, R. P.; Shimizu, N.; Irifune, T.; Nishiyama, N.

    2013-12-01

    For more than 40 years now, mantle geochemists have interpreted the isotopic signature of ocean-island basalts (OIB) in terms of deeply recycled crustal lithologies, including terrigeneous sediments, being transported via subduction into the source region for mantle plumes, which reside in the transition zone (MTZ) and/or lower mantle. As such, continent-derived sediments in particular represent domains of extreme isotopic and trace-element heterogeneity relative to the deep primitive mantle (PM). In an effort to understand the extent to which the original geochemical signature of deeply subducted continental material is preserved, and to determine which mineral phases act as reservoirs for transporting key trace-elements (e.g., large-ion lithophile elements, LILE; high-field strength elements, HFSE) into the deep mantle, we have conducted a series of phase-equilibria multi-anvil experiments on natural terrigeneous sediments at pressures appropriate to the base of the MTZ and uppermost lower mantle. The starting materials for these experiments contain modest amounts of water, and a small carbonate component, and their major- and trace-element composition are a close approximation to that of average 'global subducting sediment' (i.e., GLOSS; Plank and Langmuir, 1998). Experiments were conducted over the pressure range ~15-23 GPa, and temperatures between ~1200-1800°C. Below ~22 GPa, the high-pressure phase assemblage consists of K-hollandite, majoritic garnet, stishovite, and depending on temperature, either a hydrous alumino-silicate (e.g., phase-EGG or δ-AlOOH), or kyanite or corundum. Stable accessory minerals at these conditions include rutile, and zircon, where much of the whole-rock complement of HFSE resides, and occasionally monazite. At higher pressure (>23 GPa), the breakdown of garnet produces a Fe-Al-Mg perovskite phase, which is exceptionally rich in TiO2 (up to 9 wt%), and the aforementioned accessory phases are no longer stable. The full phase

  12. Accretion in the High-Field Magnetic Cataclysmic Variable AR Ursae Majoris

    NASA Astrophysics Data System (ADS)

    Schmidt, Gary D.; Hoard, D. W.; Szkody, Paula; Melia, Fulvio; Honeycutt, R. Kent; Wagner, R. M.

    1999-11-01

    are at odds with low-state observations. At the same time, the high magnetic field in AR UMa has yielded a new, powerful observational tool: phase-resolved Zeeman spectroscopy of the emission lines produced in the accretion stream(s). Future high-quality observations and sophisticated modeling of these features hold promise for three-dimensional reconstructions of the gas flow in high-field magnetic variables. Observations reported in this paper were obtained in part at the Multiple Mirror Telescope Observatory, a facility operated jointly by the University of Arizona and the Smithsonian Institution, and with the Apache Point Observatory (APO) 3.5 m telescope, which is owned and operated by the Astrophysical Research Consortium (ARC).

  13. High-field quasi-ballistic transport in AlGaN/GaN heterostructures

    SciTech Connect

    Danilchenko, B. A.; Tripachko, N. A.; Belyaev, A. E.; Vitusevich, S. A. Hardtdegen, H.; Lüth, H.

    2014-02-17

    Mechanisms of electron transport formation in 2D conducting channels of AlGaN/GaN heterostructures in extremely high electric fields at 4.2 K have been studied. Devices with a narrow constriction for the current flow demonstrate high-speed electron transport with an electron velocity of 6.8 × 10{sup 7} cm/s. Such a velocity is more than two times higher than values reported for conventional semiconductors and about 15% smaller than the limit value predicted for GaN. Superior velocity is attained in the channel with considerable carrier reduction. The effect is related to a carrier runaway phenomenon. The results are in good agreement with theoretical predictions for GaN-based materials.

  14. Summary of high field diffusion MRI and microscopy data demonstrate microstructural aberration in chronic mild stress rat brain.

    PubMed

    Khan, Ahmad Raza; Chuhutin, Andrey; Wiborg, Ove; Kroenke, Christopher D; Nyengaard, Jens R; Hansen, Brian; Jespersen, Sune Nørhøj

    2016-09-01

    This data article describes a large, high resolution diffusion MRI data set from fixed rat brain acquired at high field strength. The rat brain samples consist of 21 adult rat brain hemispheres from animals exposed to chronic mild stress (anhedonic and resilient) and controls. Histology from amygdala of the same brain hemispheres is also included with three different stains: DiI and Hoechst stained microscopic images (confocal microscopy) and ALDH1L1 antibody based immunohistochemistry. These stains may be used to evaluate neurite density (DiI), nuclear density (Hoechst) and astrocytic density (ALDH1L1). This combination of high field diffusion data and high resolution images from microscopy enables comparison of microstructural parameters derived from diffusion MRI to histological microstructure. The data provided here is used in the article (Jespersen, 2016) [1]. PMID:27508246

  15. P-O-B(3) linkages in borophosphate glasses evidenced by high field (11)B/(31)P correlation NMR.

    PubMed

    Tricot, G; Raguenet, B; Silly, G; Ribes, M; Pradel, A; Eckert, H

    2015-06-01

    The long-standing debate about the presence of P-O-B(3) linkages in glasses has been solved by high-field scalar correlation NMR. Previously suggested by dipolar NMR methods, the presence of such species has been definitively demonstrated by (11)B((31)P) J-HMQC NMR techniques. The results indicate that borophosphate networks contain P-O-B(3) bonds and thus present a higher degree of atomic homogeneity than previously thought. PMID:25891539

  16. Partitioning of rare earth and high field strength elements between titanite and phonolitic liquid

    NASA Astrophysics Data System (ADS)

    Olin, P. H.; Wolff, J. A.

    2012-01-01

    We present the results of a LA-ICPMS study of titanites and associated glasses from the mixed-magma phonolitic Fasnia Member of the Diego Hernández Formation, Tenerife, Canary Islands. We employ a method of identifying equilibrium mineral-melt pairs from natural samples using REE contents and a linear form of the lattice strain model equation (Blundy and Wood, 1994), where the Young's modulus (E M) for the 7-fold coordinated site is an output variable. For felsic magmas that contain crystals potentially derived from a variety of environments within the system, this approach is more rigorous than the use of solely textural criteria such as mineral-glass proximity. We then estimate titanite/melt partition coefficients for Y, Zr, Nb, REE, Hf, Ta, U and Th. In common with prior studies, we find that middle REE partition more strongly into titanite than either light or heavy REE, and that REE partitioning behavior in titanite is reasonably predicted by the lattice strain model. Titanite also fractionates Y from Ho, Zr from Hf, and Nb from Ta. Comparison with experimental data indicates that melt structure effects on partitioning are significant, most particularly in very highly polymerized melts. We use the data to estimate 7-fold coordination radii for trivalent Pr, Nd, Ho, Tm and Lu, and to make approximate predictions of titanite/melt partitioning of Ra, Ac and Pa. Interpolation of data for heavy REE does not predict the behavior of Y, indicating that factors other than charge and radius are involved in partitioning. Variations in Y/Ho induced by magmatic processes appear to be negatively correlated with temperature, and are expected to be greatest in near-minimum melts.

  17. Triple-echo steady-state T2 relaxometry of the human brain at high to ultra-high fields.

    PubMed

    Heule, Rahel; Bär, Peter; Mirkes, Christian; Scheffler, Klaus; Trattnig, Siegfried; Bieri, Oliver

    2014-09-01

    Quantitative MRI techniques, such as T2 relaxometry, have demonstrated the potential to detect changes in the tissue microstructure of the human brain with higher specificity to the underlying pathology than in conventional morphological imaging. At high to ultra-high field strengths, quantitative MR-based tissue characterization benefits from the higher signal-to-noise ratio traded for either improved resolution or reduced scan time, but is impaired by severe static (B0 ) and transmit (B1 ) field heterogeneities. The objective of this study was to derive a robust relaxometry technique for fast T2 mapping of the human brain at high to ultra-high fields, which is highly insensitive to B0 and B1 field variations. The proposed method relies on a recently presented three-dimensional (3D) triple-echo steady-state (TESS) imaging approach that has proven to be suitable for fast intrinsically B1 -insensitive T2 relaxometry of rigid targets. In this work, 3D TESS imaging is adapted for rapid high- to ultra-high-field two-dimensional (2D) acquisitions. The achieved short scan times of 2D TESS measurements reduce motion sensitivity and make TESS-based T2 quantification feasible in the brain. After validation in vitro and in vivo at 3 T, T2 maps of the human brain were obtained at 7 and 9.4 T. Excellent agreement between TESS-based T2 measurements and reference single-echo spin-echo data was found in vitro and in vivo at 3 T, and T2 relaxometry based on TESS imaging was proven to be feasible and reliable in the human brain at 7 and 9.4 T. Although prominent B0 and B1 field variations occur at ultra-high fields, the T2 maps obtained show no B0 - or B1 -related degradations. In conclusion, as a result of the observed robustness, TESS T2 may emerge as a valuable measure for the early diagnosis and progression monitoring of brain diseases in high-resolution 2D acquisitions at high to ultra-high fields.

  18. Phase 1 Final Technical Report - MgB2 Synthesis for High Field Performance

    SciTech Connect

    Mohit Bhatia; Peter McIntyre

    2009-11-02

    boron results in the formation of parasitic phases such as MgB4, MgB7, etc. Such parasitic phases are a primary element of the connectivity problem, in which even though a sample powder may contain grains of high-quality MgB2, adjacent grains are surrounded by intergrowths of parasitic phases so that current trans-port is badly degraded. The best results to date have been obtained using boron powder produced long ago for a rocket propellant development project. The synthesis process was complex and is now largely lost, and the manufacturing equipment has long since been scrapped. The last batch of the powder has been used during recent years to support MgB2 R&D at several labs, but supplies are dwindling. ATC has identified a first application of its plasma torch to synthesize phase-pure amorphous boron flake using a rapid-quench splat technique. Inexpensive technical-grade boron would be purified of contaminants, then dispersed as an aerosol in inert gas and passed through the plasma torch to melt it into a spray. The spray would be splat-condensed on a rotating drum to form pure amorphous flake. The process would begin with technical-grade boron powder, having good stoichiometric purity, nanoscale particles, but significant contamination of MgO and crystalline boron. We used wet chemistry to remove B2O3 completely and reduced the MgO impurity, and analyzed the particle size distribution using a Coulter counter and the phase composition using X-ray diffrac-tion (XRD). The next step will be to build an rf plasma torch with a recirculating single-component aerosol feed and the cooled splat drum and collector, and undertake process devel-opment for amorphous boron powder. This revised goal has two benefits. First, it is an easier technology than our ultimate goal of a multi-component laminar flow torch. We have been counseled by those experienced in plasma torch technology that our ultimate goal will require a torch that should be feasible but has never been attempted. It

  19. Development of New Electrode System for High Field Dielectric Properties Measurement Using Evaporated Polypropylene Thin Guard Film

    NASA Astrophysics Data System (ADS)

    Fujii, Masayuki; Tohyama, Kazuyuki; Tokoro, Tetsuro; Mizuno, Yukio; Nagao, Masayuki; Kosaki, Masamitsu

    Non-polar polymers such as polyethylene (PE) and polypropylene (PP) are widely used as very important electrical insulating and dielectric materials. They are used in the increasingly high AC electric field strength region approaching to the limit of electrical breakdown strength of the materials. Therefore the study of high-field dielectric property is very important in terms of understanding the AC breakdown mechanism of materials. A three-terminals electrode system with a guard film (new type electrode system) was developed in our laboratory for the precise measurement of high-field tanδ, where the guard film was used to reduce the disturbance of electric field around the edge of a main electrode. However, minute air sometimes steals between a sample film and the guard film. The air sometimes generates partial discharge in the high electric field region. Therefore, when the sample had minute air, the new type electrode system was limited under 100kVrms/mm application that didn't reach to an intrinsic breakdown strength of the 30μm-thick sample. We tried to improve the new electrode system without minute air between a sample film and the guard film. We also tried to make very thin guard film to reduce the field disturbance at the edge of main electrode. In this paper a PP-guard film on a biaxially oriented polypropylene (BOPP) film was made by evaporation. This improvement of the electrode system using the evaporated PP-guard film was in success so that high-field dielectric properties of BOPP film could be measured up to near the intrinsic breakdown field of the sample.

  20. Observation of High-Field-Side Crash and Heat Transfer during Sawtooth Oscillation in Magnetically Confined Plasmas

    SciTech Connect

    Park, H.K.; Mazzucato, E.; Luhmann, N.C. Jr.; Domier, C.W.; Xia, Z.; Donne, A.J.H.; Classen, I.G.J.; Pol, M.J. van de; Munsat, T.

    2006-05-19

    High resolution (temporal and spatial), two-dimensional images of electron temperature fluctuations during sawtooth oscillations were employed to study the crash process and heat transfer in magnetically confined toroidal plasmas. The combination of kink and local pressure driven instabilities leads to a small poloidally localized puncture in the magnetic surface at both the low and the high field sides of the poloidal plane. This observation closely resembles the 'fingering event' of the ballooning mode model with the high-m mode only predicted at the low field side.

  1. The applicability of analytical-band Monte Carlo for modelling high field electron transport in GaAs

    NASA Astrophysics Data System (ADS)

    Choo, K. Y.; Ong, D. S.

    2004-08-01

    An analytical-band Monte Carlo model incorporating four non-parabolic spherical valleys to represent the first two conduction bands has been developed to model hot electron transport and impact ionization in GaAs. We have tested the performance of this simple model against full-band Monte Carlo simulations for calculating the probability distribution function of impact ionization path length, time and energy; and transient velocity overshoot at high fields. This simpler model is found capable of reproducing the full-band model results satisfactorily but at much lower computational cost.

  2. Design of shared instruments to utilize simulated gravities generated by a large-gradient, high-field superconducting magnet

    NASA Astrophysics Data System (ADS)

    Wang, Y.; Yin, D. C.; Liu, Y. M.; Shi, J. Z.; Lu, H. M.; Shi, Z. H.; Qian, A. R.; Shang, P.

    2011-03-01

    A high-field superconducting magnet can provide both high-magnetic fields and large-field gradients, which can be used as a special environment for research or practical applications in materials processing, life science studies, physical and chemical reactions, etc. To make full use of a superconducting magnet, shared instruments (the operating platform, sample holders, temperature controller, and observation system) must be prepared as prerequisites. This paper introduces the design of a set of sample holders and a temperature controller in detail with an emphasis on validating the performance of the force and temperature sensors in the high-magnetic field.

  3. High-Field Hall Resistivity and Magnetoresistance of Electron-Doped Pr2-xCexCuO4-δ

    NASA Astrophysics Data System (ADS)

    Li, Pengcheng; Balakirev, F. F.; Greene, R. L.

    2007-07-01

    We report resistivity and Hall effect measurements in electron-doped Pr2-xCexCuO4-δ films in magnetic field up to 58 T. In contrast to hole-doped cuprates, we find a surprising nonlinear magnetic field dependence of Hall resistivity at high field in the optimally doped and overdoped films. We also observe a crossover from quadratic to linear field dependence of the positive magnetoresistance in the overdoped films. A spin density wave induced Fermi surface reconstruction model can be used to qualitatively explain both the Hall effect and magnetoresistance.

  4. DOE/University instrumentation program grant for funding of the high field, high mass, double focusing, high resolution mass spectrometer

    SciTech Connect

    Not Available

    1987-06-01

    This document discusses the research efforts accomplished using the double focusing, high field, high resolution mass spectrometer, Model JMS HX-100HF (JEOL). Installation of this instrument was accomplished during March of 1986 and operation of the instrument for purposes of application to biological and biochemical problems started during the month of April 1986. areas of research include post-translational modifications of rubisco, biosynthesis of abscisic acid, environmental control of plant development, plant cell wall protein, structural studies of thioltransferase and hexokinase and analogs of peptide harmones and neurotransmitters. 1 fig.

  5. Magnetic properties of superconducting GdBa2Cu3O(6 + delta) at low temperature and high field

    NASA Technical Reports Server (NTRS)

    Huang, C. Y.; Shapira, Y.; Hor, P. H.; Meng, R. L.; Chu, C. W.

    1988-01-01

    The magnetization of antiferromagnetic superconducting GdBa2Cu3O(6 + delta) has been measured for T in the range of 1.5 - 4.2 K for magnetic fields up to about 20 T. It is found that all Gd(3+) spins are nearly parallel at very high fields, and that this saturated spin subsystem coexists with superconductivity. Below the Neel temperature, 2.22 K, the transition from the 'canted' phase to the paramagnetic phase is observed by the application of a high magnetic field. The temperature dependence of this phase transition is also reported.

  6. Studies of $${\\rm Nb}_{3}{\\rm Sn}$$ Strands Based on the Restacked-Rod Process for High Field Accelerator Magnets

    DOE PAGES

    Barzi, E.; Bossert, M.; Gallo, G.; Lombardo, V.; Turrioni, D.; Yamada, R.; Zlobin, A. V.

    2011-12-21

    A major thrust in Fermilab's accelerator magnet R&D program is the development of Nb3Sn wires which meet target requirements for high field magnets, such as high critical current density, low effective filament size, and the capability to withstand the cabling process. The performance of a number of strands with 150/169 restack design produced by Oxford Superconducting Technology was studied for round and deformed wires. To optimize the maximum plastic strain, finite element modeling was also used as an aid in the design. Results of mechanical, transport and metallographic analyses are presented for round and deformed wires.

  7. The reverse mode of the photo activated charge domain in high field biased semi-insulating GaAs

    NASA Astrophysics Data System (ADS)

    Qu, Guanghui; Shi, Wei

    2013-02-01

    The nonlinear accumulation of the photogenerated electrons in high field biased SI-GaAs has been defined as photo activated charge domain (PACD). The transient transport dynamics of the PACD is investigated. The result shows that the PACD, working as a reverse gun dipole domain when biased electric field much higher than 4 kV/cm, and the reverse mode of the PACD could dominate the electric field shielding by its main electric field ultrafast and exponential rising against the bias field. Such mechanisms could play an important role in GaAs THz antenna, GaAs photoconductive semiconductor switch, and the other ultrafast GaAs devices.

  8. Windows on the human body--in vivo high-field magnetic resonance research and applications in medicine and psychology.

    PubMed

    Moser, Ewald; Meyerspeer, Martin; Fischmeister, Florian Ph S; Grabner, Günther; Bauer, Herbert; Trattnig, Siegfried

    2010-01-01

    Analogous to the evolution of biological sensor-systems, the progress in "medical sensor-systems", i.e., diagnostic procedures, is paradigmatically described. Outstanding highlights of this progress are magnetic resonance imaging (MRI) and spectroscopy (MRS), which enable non-invasive, in vivo acquisition of morphological, functional, and metabolic information from the human body with unsurpassed quality. Recent achievements in high and ultra-high field MR (at 3 and 7 Tesla) are described, and representative research applications in Medicine and Psychology in Austria are discussed. Finally, an overview of current and prospective research in multi-modal imaging, potential clinical applications, as well as current limitations and challenges is given.

  9. Toward increased concentration sensitivity for continuous wave EPR investigations of spin-labeled biological macromolecules at high fields

    NASA Astrophysics Data System (ADS)

    Song, Likai; Liu, Zhanglong; Kaur, Pavanjeet; Esquiaqui, Jackie M.; Hunter, Robert I.; Hill, Stephen; Smith, Graham M.; Fanucci, Gail E.

    2016-04-01

    High-field, high-frequency electron paramagnetic resonance (EPR) spectroscopy at W-(∼94 GHz) and D-band (∼140 GHz) is important for investigating the conformational dynamics of flexible biological macromolecules because this frequency range has increased spectral sensitivity to nitroxide motion over the 100 ps to 2 ns regime. However, low concentration sensitivity remains a roadblock for studying aqueous samples at high magnetic fields. Here, we examine the sensitivity of a non-resonant thin-layer cylindrical sample holder, coupled to a quasi-optical induction-mode W-band EPR spectrometer (HiPER), for continuous wave (CW) EPR analyses of: (i) the aqueous nitroxide standard, TEMPO; (ii) the unstructured to α-helical transition of a model IDP protein; and (iii) the base-stacking transition in a kink-turn motif of a large 232 nt RNA. For sample volumes of ∼50 μL, concentration sensitivities of 2-20 μM were achieved, representing a ∼10-fold enhancement compared to a cylindrical TE011 resonator on a commercial Bruker W-band spectrometer. These results therefore highlight the sensitivity of the thin-layer sample holders employed in HiPER for spin-labeling studies of biological macromolecules at high fields, where applications can extend to other systems that are facilitated by the modest sample volumes and ease of sample loading and geometry.

  10. Network Neurodegeneration in Alzheimer’s Disease via MRI Based Shape Diffeomorphometry and High-Field Atlasing

    PubMed Central

    Miller, Michael I.; Ratnanather, J. Tilak; Tward, Daniel J.; Brown, Timothy; Lee, David S.; Ketcha, Michael; Mori, Kanami; Wang, Mei-Cheng; Mori, Susumu; Albert, Marilyn S.; Younes, Laurent

    2015-01-01

    This paper examines MRI analysis of neurodegeneration in Alzheimer’s Disease (AD) in a network of structures within the medial temporal lobe using diffeomorphometry methods coupled with high-field atlasing in which the entorhinal cortex is partitioned into eight subareas. The morphometry markers for three groups of subjects (controls, preclinical AD, and symptomatic AD) are indexed to template coordinates measured with respect to these eight subareas. The location and timing of changes are examined within the subareas as it pertains to the classic Braak and Braak staging by comparing the three groups. We demonstrate that the earliest preclinical changes in the population occur in the lateral most sulcal extent in the entorhinal cortex (alluded to as transentorhinal cortex by Braak and Braak), and then proceeds medially which is consistent with the Braak and Braak staging. We use high-field 11T atlasing to demonstrate that the network changes are occurring at the junctures of the substructures in this medial temporal lobe network. Temporal progression of the disease through the network is also examined via changepoint analysis, demonstrating earliest changes in entorhinal cortex. The differential expression of rate of atrophy with progression signaling the changepoint time across the network is demonstrated to be signaling in the intermediate caudal subarea of the entorhinal cortex, which has been noted to be proximal to the hippocampus. This coupled to the findings of the nearby basolateral involvement in amygdala demonstrates the selectivity of neurodegeneration in early AD. PMID:26284236

  11. Toward increased concentration sensitivity for continuous wave EPR investigations of spin-labeled biological macromolecules at high fields.

    PubMed

    Song, Likai; Liu, Zhanglong; Kaur, Pavanjeet; Esquiaqui, Jackie M; Hunter, Robert I; Hill, Stephen; Smith, Graham M; Fanucci, Gail E

    2016-04-01

    High-field, high-frequency electron paramagnetic resonance (EPR) spectroscopy at W-(∼94 GHz) and D-band (∼140 GHz) is important for investigating the conformational dynamics of flexible biological macromolecules because this frequency range has increased spectral sensitivity to nitroxide motion over the 100 ps to 2 ns regime. However, low concentration sensitivity remains a roadblock for studying aqueous samples at high magnetic fields. Here, we examine the sensitivity of a non-resonant thin-layer cylindrical sample holder, coupled to a quasi-optical induction-mode W-band EPR spectrometer (HiPER), for continuous wave (CW) EPR analyses of: (i) the aqueous nitroxide standard, TEMPO; (ii) the unstructured to α-helical transition of a model IDP protein; and (iii) the base-stacking transition in a kink-turn motif of a large 232 nt RNA. For sample volumes of ∼50 μL, concentration sensitivities of 2-20 μM were achieved, representing a ∼10-fold enhancement compared to a cylindrical TE011 resonator on a commercial Bruker W-band spectrometer. These results therefore highlight the sensitivity of the thin-layer sample holders employed in HiPER for spin-labeling studies of biological macromolecules at high fields, where applications can extend to other systems that are facilitated by the modest sample volumes and ease of sample loading and geometry.

  12. Noninvasive quantitative mapping of conductivity and dielectric distributions using RF wave propagation effects in high-field MRI

    NASA Astrophysics Data System (ADS)

    Wen, Han

    2003-06-01

    In this paper I show with phantom and animal experiments a non-invasive and quantitative method for measuring the conductivity and dielectric distributions based on high field magnetic resonance imaging. High field MRI is accompanied by significant RF wave propagation effects. They are observed as phase and magnitude variations of the image that cannot be removed by optimizing the static field homogeneity, or by improving the RF coils. These variations reflect the RF field distribution in the sample, and in fact obey a modified Helmholtz equation. By mapping both the phase and magnitude of the field with MRI techniques, both the conductivity and the dielectric constant are determined non-invasively. In phantom experiments at 1.5 tesla, conductivity values were measured at 4 mm resolution to 0.5 S/m accuracy. At 4.7 tesla, the accuracy was improved to 0.2 S/m, and the dielectric constant was measured to an accuracy of 5 (relative to vacuum) for 2cm regions.

  13. Limits of NbTi and Nb3Sn, and development of W& R Bi-2212 High Field Accelerator Magnets

    SciTech Connect

    Cheng, Daniel; Dietderich, Daniel; Ferrracin, Paolo; Prestemon, Soren; Sabbi, GianLuca; Scanlan, Ron; Godeke, A.

    2007-06-01

    NbTi accelerator dipoles are limited to magnetic fields (H) of about 10 T, due to an intrinsic upper critical field (H{sub c2}) limitation of 14 T. To surpass this restriction, prototype Nb{sub 3}Sn magnets are being developed which have reached 16 T. We show that Nb{sub 3}Sn dipole technology is practically limited to 17 to 18 T due to insufficient high field pinning, and intrinsically to 20 to 22 T due to H{sub c2} limitations. Therefore, to obtain magnetic fields approaching 20 T and higher, a material is required with a higher H{sub c2} and sufficient high field pinning capacity. A realistic candidate for this purpose is Bi-2212, which is available in round wires and sufficient lengths for the fabrication of coils based on Rutherford-type cables. We initiated a program to develop the required technology to construct accelerator magnets from 'wind-and-react' (W&R) Bi-2212 coils. We outline the complications that arise through the use of Bi-2212, describe the development paths to address these issues, and conclude with the design of W&R Bi-2212 sub-scale magnets.

  14. Brain-heart interactions: challenges and opportunities with functional magnetic resonance imaging at ultra-high field.

    PubMed

    Chang, Catie; Raven, Erika P; Duyn, Jeff H

    2016-05-13

    Magnetic resonance imaging (MRI) at ultra-high field (UHF) strengths (7 T and above) offers unique opportunities for studying the human brain with increased spatial resolution, contrast and sensitivity. However, its reliability can be compromised by factors such as head motion, image distortion and non-neural fluctuations of the functional MRI signal. The objective of this review is to provide a critical discussion of the advantages and trade-offs associated with UHF imaging, focusing on the application to studying brain-heart interactions. We describe how UHF MRI may provide contrast and resolution benefits for measuring neural activity of regions involved in the control and mediation of autonomic processes, and in delineating such regions based on anatomical MRI contrast. Limitations arising from confounding signals are discussed, including challenges with distinguishing non-neural physiological effects from the neural signals of interest that reflect cardiorespiratory function. We also consider how recently developed data analysis techniques may be applied to high-field imaging data to uncover novel information about brain-heart interactions.

  15. Brain-heart interactions: challenges and opportunities with functional magnetic resonance imaging at ultra-high field.

    PubMed

    Chang, Catie; Raven, Erika P; Duyn, Jeff H

    2016-05-13

    Magnetic resonance imaging (MRI) at ultra-high field (UHF) strengths (7 T and above) offers unique opportunities for studying the human brain with increased spatial resolution, contrast and sensitivity. However, its reliability can be compromised by factors such as head motion, image distortion and non-neural fluctuations of the functional MRI signal. The objective of this review is to provide a critical discussion of the advantages and trade-offs associated with UHF imaging, focusing on the application to studying brain-heart interactions. We describe how UHF MRI may provide contrast and resolution benefits for measuring neural activity of regions involved in the control and mediation of autonomic processes, and in delineating such regions based on anatomical MRI contrast. Limitations arising from confounding signals are discussed, including challenges with distinguishing non-neural physiological effects from the neural signals of interest that reflect cardiorespiratory function. We also consider how recently developed data analysis techniques may be applied to high-field imaging data to uncover novel information about brain-heart interactions. PMID:27044994

  16. Comprehensive untargeted lipidomic analysis using core-shell C30 particle column and high field orbitrap mass spectrometer.

    PubMed

    Narváez-Rivas, Mónica; Zhang, Qibin

    2016-04-01

    The goal of untargeted lipidomics is to have high throughput, yet comprehensive and unambiguous identification and quantification of lipids. Novel stationary phases in LC separation and new mass spectrometric instruments capable of high mass resolving power and faster scanning rate are essential to achieving this goal. In this work, 4 reversed phase LC columns coupled with a high field quadrupole orbitrap mass spectrometer (Q Exactive HF) were thoroughly compared using complex lipid standard mixture and rat plasma and liver samples. A good separation of all lipids was achieved in 24min of gradient. The columns compared include C30 and C18 functionalization on either core-shell or totally porous silica particles, with size ranging from 1.7 to 2.6μm. Accucore C30 column showed the narrowest peaks and highest theoretical plate number, and excellent peak capacity and retention time reproducibility (<1% standard deviation). As a result, it resulted in 430 lipid species identified from rat plasma and rat liver samples with highest confidence. The high resolution offered by the up-front RPLC allowed discrimination of cis/trans isomeric lipid species, and the high field orbitrap mass spectrometer afforded the clear distinction of isobaric lipid species in full scan MS and the unambiguous assignment of sn-positional isomers for lysophospholipids in MS/MS. Taken together, the high efficiency LC separation and high mass resolving MS analysis are very promising tools for untargeted lipidomics analysis. PMID:26928874

  17. High field superconducting magnets

    NASA Technical Reports Server (NTRS)

    Hait, Thomas P. (Inventor); Shirron, Peter J. (Inventor)

    2011-01-01

    A superconducting magnet includes an insulating layer disposed about the surface of a mandrel; a superconducting wire wound in adjacent turns about the mandrel to form the superconducting magnet, wherein the superconducting wire is in thermal communication with the mandrel, and the superconducting magnet has a field-to-current ratio equal to or greater than 1.1 Tesla per Ampere; a thermally conductive potting material configured to fill interstices between the adjacent turns, wherein the thermally conductive potting material and the superconducting wire provide a path for dissipation of heat; and a voltage limiting device disposed across each end of the superconducting wire, wherein the voltage limiting device is configured to prevent a voltage excursion across the superconducting wire during quench of the superconducting magnet.

  18. High field X-ray diffraction measurements of Mn2Sb0.95Ge0.05

    NASA Astrophysics Data System (ADS)

    Wakamori, Taoto; Mitsui, Yoshifuru; Takahashi, Kohki; Umetsu, Rie Y.; Hiroi, Masahiko; Koyama, Keiichi

    2016-08-01

    Magnetization and high-field X-ray powder diffraction measurements were performed for Mn2Sb0.95Ge0.05 with a tetragonal structure in magnetic fields up to 5 T in the 10-300 K temperature range. For B = 0 T and 5 T, a first-order magnetic transition from a ferrimagnetic (FRI) to an antiferromagnetic (AFM) state occurred at Tt ˜ 180 K and 150 K, respectively, and were accompanied by an iso-structural transformation. For this transition from the AFM to FRI state, the lattice parameters a and c changed by |Δa/a| = 0.15% and by |Δc/c| = 0.47% at 180 K. The compound showed both metamagnetic transition from the AFM to FRI state with a hysteresis at the temperature just below Tt and magnetic field-induced iso-structural transformation.

  19. Windows on the Human Body – in Vivo High-Field Magnetic Resonance Research and Applications in Medicine and Psychology

    PubMed Central

    Moser, Ewald; Meyerspeer, Martin; Fischmeister, Florian Ph. S.; Grabner, Günther; Bauer, Herbert; Trattnig, Siegfried

    2010-01-01

    Analogous to the evolution of biological sensor-systems, the progress in “medical sensor-systems”, i.e., diagnostic procedures, is paradigmatically described. Outstanding highlights of this progress are magnetic resonance imaging (MRI) and spectroscopy (MRS), which enable non-invasive, in vivo acquisition of morphological, functional, and metabolic information from the human body with unsurpassed quality. Recent achievements in high and ultra-high field MR (at 3 and 7 Tesla) are described, and representative research applications in Medicine and Psychology in Austria are discussed. Finally, an overview of current and prospective research in multi-modal imaging, potential clinical applications, as well as current limitations and challenges is given. PMID:22219684

  20. Test Results of HD2, A High Field Nb3Sn Dipole with A 36 MM Bore

    SciTech Connect

    Ferracin, Paolo

    2008-05-19

    The Superconducting Magnet Program at Lawrence Berkeley National Laboratory (LBNL) has developed the 1 m long Nb{sub 3}Sn dipole magnet HD2. With tilted (flared) ends to avoid obstructing a 36 mm clear bore, HD2 represents a step towards the use of block-type coils in high-field accelerator magnets. The coil design has been optimized to minimize geometric harmonics and reduce the conductor peak field in the end region, resulting in an expected short sample dipole field of 15 T. The support structure is composed by an external aluminum shell pre-tensioned with pressurized bladders and interference keys, and by two stainless steel end plates compressing the coil ends through four aluminum axial rods. We report on magnet design, assembly, and test results, including training performance, quench locations, and strain gauge measurements.

  1. The high field superferric magnet Design and test of a new dipole magnet for future hadron colliders

    NASA Astrophysics Data System (ADS)

    Colvin, John C.; Hinterberger, Henry; Russell Huson, F.; Mackay, William W.; Mann, Thomas L.; McIntyre, Peter M.; Phillips, Gerald C.; Pissanetzky, Sergio; Rocha, Richard; Schmidt, William M.; Shotzman, Garry; Wenzel, William A.; Fen Xie, Wan; Zeigler, John C.

    1988-07-01

    The Texas Accelerator Center has successfully tested a 6 T superferric dipole magnet of a design appropriate for future hadron colliders. The magnet surpassed the design field (90% of the short sample limit) on its first quench without training. The measured field quality is in excellent agreement with design calculations and meets collider requirements. The magnetic field design was developed at Rice University and is the subject of a Master's thesis. The features of the design include simple construction, efficient use of superconductor, and adequate containment of magnetic forces. A straightforward extension of the design to an 8 T dipole is under development. The high-field superferric magnet constitutes a significant improvement in magnet performance and cost for future accelerators.

  2. High-field paramagnetic Meissner effect and flux creep in low-T c Ti-V alloy superconductors

    NASA Astrophysics Data System (ADS)

    Matin, M.; Chattopadhyay, M. K.; Sharath Chandra, L. S.; Roy, S. B.

    2016-02-01

    We report an experimental study on the high-field paramagnetic Meissner effect (HFPME) performed by measuring both the temperature and time dependence of magnetization in the two compositions of superconducting Ti-V alloys where certain secondary phases are non-superconducting, and thereby act as efficient pinning centres for the flux lines. While spatially non-uniform flux density driven by flux line pinning at these secondary phases is the necessary condition for the observation of the HFPME, our study indicates that the flux creep effect plays a supplementary role to reinforce the HFPME. It is found that in the temperature and magnetic field regime of the HFPME, the field-cooled magnetization of these samples relaxes monotonically towards a more positive value with elapsed time. We comment on how this paramagnetic relaxation behaviour of the field-cooled magnetization is correlated with the unusual thermo-magnetic responses related to the HFPME.

  3. Separation of Opiate Isomers Using Electrospray Ionization and Paper Spray Coupled to High-Field Asymmetric Waveform Ion Mobility Spectrometry

    NASA Astrophysics Data System (ADS)

    Manicke, Nicholas E.; Belford, Michael

    2015-05-01

    One limitation in the growing field of ambient or direct analysis methods is reduced selectivity caused by the elimination of chromatographic separations prior to mass spectrometric analysis. We explored the use of high-field asymmetric waveform ion mobility spectrometry (FAIMS), an ambient pressure ion mobility technique, to separate the closely related opiate isomers of morphine, hydromorphone, and norcodeine. These isomers cannot be distinguished by tandem mass spectrometry. Separation prior to MS analysis is, therefore, required to distinguish these compounds, which are important in clinical chemistry and toxicology. FAIMS was coupled to a triple quadrupole mass spectrometer, and ionization was performed using either a pneumatically assisted heated electrospray ionization source (H-ESI) or paper spray, a direct analysis method that has been applied to the direct analysis of dried blood spots and other complex samples. We found that FAIMS was capable of separating the three opiate structural isomers using both H-ESI and paper spray as the ionization source.

  4. Modified Johnson model for ferroelectric lead lanthanum zirconate titanate at very high fields and below Curie temperature.

    SciTech Connect

    Narayanan, M.; Tong, S.; Ma, B.; Liu, S.; Balachandran, U.

    2012-01-01

    A modified Johnson model is proposed to describe the nonlinear field dependence of the dielectric constant ({var_epsilon}-E loop) in ferroelectric materials below the Curie temperature. This model describes the characteristic ferroelectric 'butterfly' shape observed in typical {var_epsilon}-E loops. The predicted nonlinear behavior agreed well with the measured values in both the low- and high-field regions for lead lanthanum zirconate titanate films. The proposed model was also validated at different temperatures below the ferroelectric-to-paraelectric Curie point. The anharmonic coefficient in the model decreased from 6.142 x 10{sup -19} cm{sup 2}/V{sup 2} to 2.039 x 10{sup -19} cm{sup 2}/V{sup 2} when the temperature increased from 25 C to 250 C.

  5. High-Field Fast-Risetime Pulse Failures in 4H- and 6H-SiC pn Junction Diodes

    NASA Technical Reports Server (NTRS)

    Neudeck, Philip G.; Fazi, Christian

    1996-01-01

    We report the observation of anomalous reverse breakdown behavior in moderately doped (2-3 x 10(exp 17 cm(exp -3)) small-area micropipe-free 4H- and 6H-SiC pn junction diodes. When measured with a curve tracer, the diodes consistently exhibited very low reverse leakage currents and sharp repeatable breakdown knees in the range of 140-150 V. However, when subjected to single-shot reverse bias pulses (200 ns pulsewidth, 1 ns risetime), the diodes failed catastrophically at pulse voltages of less than 100 V. We propose a possible mechanism for this anomalous reduction in pulsed breakdown voltage relative to dc breakdown voltage. This instability must be removed so that SiC high-field devices can operate with the same high reliability as silicon power devices.

  6. Disappearance of Ising nature in Ca3ZnMnO6 studied by high-field ESR.

    PubMed

    Ruan, M Y; Ouyang, Z W; Guo, Y M; Cheng, J J; Sun, Y C; Xia, Z C; Rao, G H; Okubo, S; Ohta, H

    2014-06-11

    High-field electron spin resonance measurements of an antiferromagnet Ca3ZnMnO6 isostructure, with the Ising-chain multiferroic Ca3CoMnO6, have been carried out. Two distinct resonance modes were observed below TN = 25 K, which is well explained by conventional antiferromagnetic resonance theory with easy-plane anisotropy. The zero-field spin gap is derived to be about 166 GHz, originating from the easy-plane anisotropy and exchange interaction. Our result suggests that the Dzyaloshinsky-Moriya interaction, which may induce spin canting, is absent. Disappearance of Ising anisotropy in Ca3ZnMnO6 suggests that the Co(4+) ion, as well as the Co-Mn superexchange, plays an important role for the Ising nature in Ca3CoMnO6. PMID:24828049

  7. Microstructural understanding and critical current optimization of advanced high field superconductors. Progress report, February 1, 1991--March 31, 1993

    SciTech Connect

    Bonney, L.A.; Willis, T.C.; Larbalestier, D.C.

    1993-04-01

    It is of great importance to improve critical current density, J{sub c} in A15 superconductors for high field magnet applications. Most current work to improve J{sub c} in A15 wires concentrates on increasing the overall J{sub c} by increasing the fraction of superconducting phase in the wire, by improving the uniformity of the superconductor cross section along the length of the wire and by adjusting the strainstate of the A15 layer. The goal of the A15 work in this group was to investigate the intrinsic J{sub c} of the A15 layer itself. To do this, a better understanding of factors controlling the intrinsic J{sub c}of the Nb{sub 3}Sn was pursued.

  8. A field-sweep/field-lock system for superconducting magnets--Application to high-field EPR.

    PubMed

    Maly, Thorsten; Bryant, Jeff; Ruben, David; Griffin, Robert G

    2006-12-01

    We describe a field-lock/field-sweep system for the use in superconducting magnets. The system is based on a commercially available field mapping unit and a custom designed broad-band 1H NMR probe. The NMR signal of a small water sample is used in a feedback loop to set and control the magnetic field to high accuracy. The current instrumental configuration allows field sweeps of +/-0.4 T and a resolution of up to 10(-5) T (0.1 G) and the performance of the system is demonstrated in a high-field electron paramagnetic resonance (EPR) application. The system should also be of utility in other experiments requiring precise and reproducible sweeps of the magnetic field such as DNP, ENDOR or PELDOR.

  9. A Field-Sweep/Field-Lock System for Superconducting Magnets-Application to High-Field EPR

    PubMed Central

    Maly, Thorsten; Bryant, Jeff; Ruben, David; Griffin, Robert G.

    2007-01-01

    We describe a field-lock/field-sweep system for the use in superconducting magnets. The system is based on a commercially available field mapping unit and a custom designed broad-band 1H-NMR probe. The NMR signal of a small water sample is used in a feedback loop to set and control the magnetic field to high accuracy. The current instrumental configuration allows field sweeps of ± 0.4 T and a resolution of up to 10-5 T (0.1 G) and the performance of the system is demonstrated in a high-field electron paramagnetic resonance (EPR) application. The system should also be of utility in other experiments requiring precise and reproducible sweeps of the magnetic field such as DNP, ENDOR or PELDOR. PMID:17027306

  10. An analysis approach for high-field fMRI data from awake non-human primates.

    PubMed

    Stoewer, Steffen; Goense, Jozien; Keliris, Georgios A; Bartels, Andreas; Logothetis, Nikos K; Duncan, John; Sigala, Natasha

    2012-01-01

    fMRI experiments with awake non-human primates (NHP) have seen a surge of applications in recent years. However, the standard fMRI analysis tools designed for human experiments are not optimal for analysis of NHP fMRI data collected at high fields. There are several reasons for this, including the trial-based nature of NHP experiments, with inter-trial periods being of no interest, and segmentation artefacts and distortions that may result from field changes due to movement. We demonstrate an approach that allows us to address some of these issues consisting of the following steps: 1) Trial-based experimental design. 2) Careful control of subject movement. 3) Computer-assisted selection of trials devoid of artefacts and animal motion. 4) Nonrigid between-trial and rigid within-trial realignment of concatenated data from temporally separated trials and sessions. 5) Linear interpolation of inter-trial intervals and high-pass filtering of temporally continuous data 6) Removal of interpolated data and reconcatenation of datasets before statistical analysis with SPM. We have implemented a software toolbox, fMRI Sandbox (http://code.google.com/p/fmri-sandbox/), for semi-automated application of these processing steps that interfaces with SPM software. Here, we demonstrate that our methodology provides significant improvements for the analysis of awake monkey fMRI data acquired at high-field. The method may also be useful for clinical applications with subjects that are unwilling or unable to remain motionless for the whole duration of a functional scan.

  11. Endometrium evaluation with high-field (3-Tesla) magnetic resonance imaging in patients submitted to uterine leiomyoma embolization

    PubMed Central

    Jacobs, Monica Amadio Piazza; Nasser, Felipe; Zlotnik, Eduardo; Messina, Marcos de Lorenzo; Baroni, Ronaldo Hueb

    2013-01-01

    ABSTRACT Objective: To evaluate the endometrial alterations related to embolization of uterine arteries for the treatment of symptomatic uterine leiomyomatosis (pelvic pain and/or uterine bleeding) by means of high-field (3-Tesla) magnetic resonance. Methods: This is a longitudinal and prospective study that included 94 patients with a clinical and imaging diagnosis of symptomatic uterine leiomyomatosis, all of them treated by embolization of the uterine arteries. The patients were submitted to evaluations by high-field magnetic resonance of the pelvis before and 6 months after the procedure. Specific evaluations were made of the endometrium on the T2-weighted sequences, and on the T1-weighted sequences before and after the intravenous dynamic infusion of the paramagnetic contrast. In face of these measures, statistical analyses were performed using Student's t test for comparison of the results obtained before and after the procedure. Results: An average increase of 20.9% was noted in the endometrial signal on T2-weighted images obtained after the uterine artery embolization procedure when compared to the pre-procedure evaluation (p=0.0004). In the images obtained with the intravenous infusion of paramagnetic contrast, an average increase of 18.7% was noted in the post-embolization intensity of the endometrial signal, compared to the pre-embolization measure (p<0.035). Conclusion: After embolization of the uterine arteries, there was a significant increase of the endometrial signal on the T2-weighted images and on the post-contrast images, inferring possible edema and increased endometrial flow. Future studies are needed to assess the clinical impact of these findings. PMID:23579745

  12. Thermal and mechanical effects of quenches on Nb{sub 3}Sn high field hadron collider magnets

    SciTech Connect

    Ryuji Yamada et al.

    2001-11-05

    Thermal and its resulting mechanical stress due to quenches inside short and long epoxy impregnated Nb{sub 3}Sn high field magnets are studied with a quench simulation program, Kuench, and ANSYS program. For the protection of a long high field magnet, we have to use heaters to dump the stored energy uniformly inside the magnet, after detection of a spontaneous quench. The time delay of starting a forced quench with heaters, is estimated using ANSYS. Using this information, the thermal distribution in two-dimensional magnet cross section is studied. First a one meter model magnet with a dump resistor is used to estimate the effects and then a 10 meter long magnet is studied. The two-dimensional temperature distributions in the magnet cross sections are recorded every 5 ms, and visually displayed. With this visual animation displays we can understand intuitively the thermal and quench propagation in 2-dimensional field. The quenching cables get heated locally much more than the surrounding material and non-quenching conductor cables. With a one meter magnet with a dump resistor of 30 m{Omega}, typically only the quench starting cables and its neighbor cables get heated up to 100 K without significant effects from the heaters. With a10 meter magnet, heaters cause the quenches to most of the conductor blocks. The quench initiating cables get up to 250 to 300 K in 100 ms, but the surrounding and wedges are not heated up significantly. This causes the excessive stress in the quenching conductors and in their insulation material locally. The stress and strain in the conductor as well as in the insulation become excessive, and they are studied using the ANSYS stress analysis, using Von Mises criterion. It is concluded that for the one meter magnet with the presented cross section and configuration, the thermal effects due to the quench is tolerable. But we need much more quench study and improvements in the design for the extended ten meter long magnet [1].

  13. Comparison between computed tomography multislice and high-field magnetic resonance in the diagnostic evaluation of patients with renal masses

    PubMed Central

    Baldari, Diana; Capece, Sergio; Mainenti, Pier Paolo; Tucci, Anna Giacoma; Klain, Michele; Cozzolino, Immacolata; Salvatore, Marco

    2015-01-01

    Background Renal masses are a common finding in diagnostic imaging; these lesions usually are solid or cystic, benign or malignant, and the correct diagnosis may be difficult. The aim of our study was the comparison of multi-slice computed tomography (MSCT) and high-field magnetic resonance (MR) in the diagnostic evaluation of renal masses. Methods We studied 29 patients, 16 men and 13 women aged 8-85 years (mean 61±17 years) with histo-cytological diagnosis of renal masses (n=31), of which the majority (74%; n=23) was represented by malignant lesions [renal cell carcinoma (Ca) =16, chromophobe renal cell Ca =2, squamous cell Ca =1, urothelial Ca =2, lymphoma =1, Wilms tumor =1]; the remaining 8 masses (26%) were benign (pyelonephritis =2, simple cyst =1, hematic cyst =1, lipoma =1 and oncocytoma =3). All patients underwent MSCT and MR (3.0 Tesla) before and after contrast injection; the images were evaluated in double-blind by two expert radiologists. The results of the images were then compared with the histo-cytological data to calculate the values of diagnostic accuracy for both methods in the identification and characterization of renal masses. The benign or malignant nature of the lesions was established according to the regularity of the margins, presence or absence of significant contrast enhancement, infiltration of perirenal fat and vascular invasion. The concordance of the results of the two imaging techniques was then calculated using the coefficient Kappa Cohen. Results For both identification and characterization of renal masses, MSCT and MR showed comparable values of diagnostic accuracy with a significant concordance (k=1); in particular, the diagnostic accuracy of MSCT/MR was 100%/100% for lesion identification, 90%/90% for lesion characterization in terms of benign or malignant nature, 97%/97% for the evaluation of lesion edges, 90%/90% for the assessment of lesion contrast enhancement, 93%/93% for the evaluation of peri-renal fat infiltration

  14. Histological Confirmation and Biological Significance of Cartilage Canals Demonstrated Using High Field MRI in Swine at Predilection Sites of Osteochondrosis

    PubMed Central

    Tóth, Ferenc; Nissi, Mikko J.; Zhang, Jinjin; Benson, Michael; Schmitter, Sebastian; Ellermann, Jutta M.; Carlson, Cathy S.

    2014-01-01

    Cartilage canal vessels in epiphyseal cartilage have a pivotal role in the pathogenesis of osteochondrosis/osteochondritis dissecans. The present study aimed to validate high field magnetic resonance imaging (MRI) methods to visualize these vessels in young pigs. Osteochondral samples from the distal femur and distal humerus (predilection sites of osteochondrosis) of piglets were imaged post-mortem: (1) using susceptibility-weighted imaging (SWI) in an MRI scanner, followed by histological evaluation; and (2) after barium perfusion using μCT, followed by clearing techniques. In addition, both stifle joints of a 25-day-old piglet were imaged in vivo using SWI and gadolinium enhanced T1-weighted MRI, after which distal femoral samples were harvested and evaluated using μCT and histology. Histological sections were compared to corresponding MRI slices, and three-dimensional visualizations of vessels identified using MRI were compared to those obtained using μCT and to the cleared specimens. Vessels contained in cartilage canals were identified using MRI, both ex vivo and in vivo; their locations matched those observed in the histological sections, μCT images, and cleared specimens of barium-perfused tissues. The ability to visualize cartilage canal blood vessels by MRI, without using a contrast agent, will allow future longitudinal studies to evaluate their role in developmental orthopedic disease. PMID:23939946

  15. New Material Transistor with Record-High Field-Effect Mobility among Wide-Band-Gap Semiconductors.

    PubMed

    Shih, Cheng Wei; Chin, Albert

    2016-08-01

    At an ultrathin 5 nm, we report a new high-mobility tin oxide (SnO2) metal-oxide-semiconductor field-effect transistor (MOSFET) exhibiting extremely high field-effect mobility values of 279 and 255 cm(2)/V-s at 145 and 205 °C, respectively. These values are the highest reported mobility values among all wide-band-gap semiconductors of GaN, SiC, and metal-oxide MOSFETs, and they also exceed those of silicon devices at the aforementioned elevated temperatures. For the first time among existing semiconductor transistors, a new device physical phenomenon of a higher mobility value was measured at 45-205 °C than at 25 °C, which is due to the lower optical phonon scattering by the large SnO2 phonon energy. Moreover, the high on-current/off-current of 4 × 10(6) and the positive threshold voltage of 0.14 V at 25 °C are significantly better than those of a graphene transistor. This wide-band-gap SnO2 MOSFET exhibits high mobility in a 25-205 °C temperature range, a wide operating voltage of 1.5-20 V, and the ability to form on an amorphous substrate, rendering it an ideal candidate for multifunctional low-power integrated circuit (IC), display, and brain-mimicking three-dimensional IC applications.

  16. Assembly and Test of HD2, a 36 mm bore high field Nb3Sn Dipole Magnet

    SciTech Connect

    Ferracin, P.; Bingham, B.; Caspi, S.; Cheng, D. W,.; Dietderich, D. R.; Felice, H.; Godeke, A.; Hafalia, A. R.; Hannaford, C. R.; Joseph, J.; Lietzke, A. F.; Lizarazo, J.; Sabbi, G.; Trillaud, F.; Wang, X.

    2008-08-17

    We report on the fabrication, assembly, and test of the Nb{sub 3}Sn dipole magnet HD2. The magnet, aimed at demonstrating the application of Nb{sub 3}Sn superconductor in high field accelerator-type dipoles, features a 36 mm clear bore surrounded by block-type coils with tilted ends. The coil design is optimized to minimize geometric harmonics in the aperture and the magnetic peak field on the conductor in the coil ends. The target bore field of 15 T at 4.3 K is consistent with critical current measurements of extracted strands. The coils are horizontally pre-stressed during assembly using an external aluminum shell pre-tensioned with water-pressurized bladders. Axial pre-loading of the coil ends is accomplished through two end plates and four aluminum tension rods. The strain in coil, shell, and rods is monitored with strain gauges during assembly, cool-down and magnet excitation, and compared with 3D finite element computations. Magnet's training performance, quench locations, and ramp-rate dependence are then analyzed and discussed.

  17. Comparison Between Nb3Al and Nb3Sn Strands and Cables for High Field Accelerator Magnets

    SciTech Connect

    Yamada, R.; Kikuchi, A.; Barzi, E.; Chlachidze, G.; Rusy, A.; Takeuchi, T.; Tartaglia, M.; Turrioni, D.; Velev, V.; Wake, M.; Zlobin, A.V.; /Fermilab

    2010-01-01

    The Nb{sub 3}Al small racetrack magnet, SR07, has been successfully built and tested to its short sample limit beyond 10 Tesla without any training. Thus the practical application of Nb{sub 3}Al strands for high field accelerator magnets is established. The characteristics of the representative F4 strand and cable, are compared with the typical Nb{sub 3}Sn strand and cable. It is represented by the OST high current RRP Nb{sub 3}Sn strand with 108/127 configuration. The effects of Rutherford cabling to both type strands are explained and the inherent problem of the Nb{sub 3}Sn strand is discussed. Also the test results of two representative small racetrack magnets are compared from the stand point of Ic values, and training. The maximum current density of the Nb{sub 3}Al strands is still smaller than that of the Nb{sub 3}Sn strands, but if we take into account of the stress-strain characteristics, Nb{sub 3}Al strands become somewhat favorable in some applications.

  18. High-field 13C NMR spectroscopy of tissue in Vivo. A double-resonance surface-coil probe

    NASA Astrophysics Data System (ADS)

    Reo, Nicholas V.; Ewy, Coleen S.; Siegfried, Barry A.; Ackerman, Joseph J. H.

    A double-resonance surface-coil NMR probe is described for performance of high-field (8.5 T) proton decoupled carbon-13 experiments with tissue in vivo. The probe may be accommodated in standard, 89 mm i.d. clear bore, commercial spectrometers and is suitable for studies utilizing small laboratory animals such as mice, hamsters, and rats. A coaxial coil design is employed (10 mm diameter 13C coil, 20 mm diameter 1H coil) which provides ca. 40 dB attenuation between the 13C observe and 1H decouple channels. The inherent efficiency of the surface-coil configuration provides a sensitivity comparable to a commercial probe of the same nominal dimension (10 mm Helmholtz coil) and assures adequate decoupling in conductive samples with ca. 3-5 W power. In the absence of 13C isotopic enrichment, NMR spectra of rat leg, liver, and brain in vivo provide signalto-noise sufficient for 10 min time resolution. Administration of 100 mg of 90% 13C-labeled glucose into a peripheral vein of a ca. 300 g rat resulted in a liver glucose resonance which could be monitored with good signal-to-noise and 3 min time resolution.

  19. High-field electroluminescence in semiconductor tunnel junctions with a Mn-doped GaAs layer

    SciTech Connect

    Hai, Pham Nam; Yatsui, Takashi; Ohtsu, Motoichi; Tanaka, Masaaki

    2014-09-21

    We investigated high-field electroluminescence (EL) in semiconductor tunnel junctions with a Mn-doped GaAs layer (here, referred to as GaAs:Mn). Besides the band-gap emission of GaAs, the EL spectra show visible light emissions with two peaks at 1.94 eV and 2.19 eV, which are caused by d-d transitions of the Mn atoms excited by hot electrons. The threshold voltages for band-gap and visible light EL in the tunnel junctions with a GaAs:Mn electrode are 1.3 V higher than those of GaAs:Mn excited by hot holes in reserve biased p⁺-n junctions, which is consistent with the hot carrier transport in the band profiles of these structures. Our EL results at room temperature show that the electron temperature in GaAs:Mn can be as high as ~700 K for a low input electrical power density of 0.4 W/cm², while the lattice temperature of the GaAs:Mn layer can be kept at 340 K.

  20. Improvements in RF Shimming in High Field MRI Using High Permittivity Materials With Low Order Pre-Fractal Geometries.

    PubMed

    Schmidt, Rita; Webb, Andrew

    2016-08-01

    Ultra-high field MRI is an area of great interest for clinical research and basic science due to the increased signal-to-noise, spatial resolution and magnetic-susceptibility-based contrast. However, the fact that the electromagnetic wavelength in tissue is comparable to the relevant body dimensions means that the uniformity of the excitation field is much poorer than at lower field strengths. In addition to techniques such as transmit arrays, one simple but effective method to counteract this effect is to use high permittivity "pads". Very high permittivities enable thinner, flexible pads to be used, but the limiting factor is wavelength effects within the pads themselves, which can lead to image artifacts. So far, all studies have used simple continuous rectangular/circular pad geometries. In this work we investigate how the wavelength effects can be partially mitigated utilizing shaped pad with holes. Several arrangements have been simulated, including low order pre-fractal geometries, which maintain the overall coverage of the pad, but can provide better image homogeneity in the region of interest or higher sensitivity depending on the setup. Experimental data in the form of in vivo human images at 7T were acquired to validate the simulation results. PMID:26890643

  1. New Material Transistor with Record-High Field-Effect Mobility among Wide-Band-Gap Semiconductors.

    PubMed

    Shih, Cheng Wei; Chin, Albert

    2016-08-01

    At an ultrathin 5 nm, we report a new high-mobility tin oxide (SnO2) metal-oxide-semiconductor field-effect transistor (MOSFET) exhibiting extremely high field-effect mobility values of 279 and 255 cm(2)/V-s at 145 and 205 °C, respectively. These values are the highest reported mobility values among all wide-band-gap semiconductors of GaN, SiC, and metal-oxide MOSFETs, and they also exceed those of silicon devices at the aforementioned elevated temperatures. For the first time among existing semiconductor transistors, a new device physical phenomenon of a higher mobility value was measured at 45-205 °C than at 25 °C, which is due to the lower optical phonon scattering by the large SnO2 phonon energy. Moreover, the high on-current/off-current of 4 × 10(6) and the positive threshold voltage of 0.14 V at 25 °C are significantly better than those of a graphene transistor. This wide-band-gap SnO2 MOSFET exhibits high mobility in a 25-205 °C temperature range, a wide operating voltage of 1.5-20 V, and the ability to form on an amorphous substrate, rendering it an ideal candidate for multifunctional low-power integrated circuit (IC), display, and brain-mimicking three-dimensional IC applications. PMID:27454211

  2. Decreased Gap Width in a Cylindrical High-Field Asymmetric Waveform Ion Mobility Spectrometry Device Improves Protein Discovery.

    PubMed

    Swearingen, Kristian E; Winget, Jason M; Hoopmann, Michael R; Kusebauch, Ulrike; Moritz, Robert L

    2015-12-15

    High-field asymmetric waveform ion mobility spectrometry (FAIMS) is an atmospheric pressure ion mobility technique that separates gas phase ions according to their characteristic dependence of ion mobility on electric field strength. FAIMS can be implemented as a means of automated gas-phase fractionation in liquid chromatography-tandem mass spectrometry (LC-MS/MS) experiments. We modified a commercially available cylindrical FAIMS device by enlarging the inner electrode, thereby narrowing the gap and increasing the effective field strength. This modification provided a nearly 4-fold increase in FAIMS peak capacity over the optimally configured unmodified device. We employed the modified FAIMS device for on-line fractionation in a proteomic analysis of a complex sample and observed major increases in protein discovery. NanoLC-FAIMS-MS/MS of an unfractionated yeast tryptic digest using the modified FAIMS device identified 53% more proteins than were identified using an unmodified FAIMS device and 98% more proteins than were identified with unaided nanoLC-MS/MS. We describe here the development of a nanoLC-FAIMS-MS/MS protocol that provides automated gas-phase fractionation for proteomic analysis of complex protein digests. We compare this protocol against prefractionation of peptides with isoelectric focusing and demonstrate that FAIMS fractionation yields comparable protein recovery while significantly reducing the amount of sample required and eliminating the need for additional sample handling. PMID:26560994

  3. GPU-accelerated FDTD modeling of radio-frequency field-tissue interactions in high-field MRI.

    PubMed

    Chi, Jieru; Liu, Feng; Weber, Ewald; Li, Yu; Crozier, Stuart

    2011-06-01

    The analysis of high-field RF field-tissue interactions requires high-performance finite-difference time-domain (FDTD) computing. Conventional CPU-based FDTD calculations offer limited computing performance in a PC environment. This study presents a graphics processing unit (GPU)-based parallel-computing framework, producing substantially boosted computing efficiency (with a two-order speedup factor) at a PC-level cost. Specific details of implementing the FDTD method on a GPU architecture have been presented and the new computational strategy has been successfully applied to the design of a novel 8-element transceive RF coil system at 9.4 T. Facilitated by the powerful GPU-FDTD computing, the new RF coil array offers optimized fields (averaging 25% improvement in sensitivity, and 20% reduction in loop coupling compared with conventional array structures of the same size) for small animal imaging with a robust RF configuration. The GPU-enabled acceleration paves the way for FDTD to be applied for both detailed forward modeling and inverse design of MRI coils, which were previously impractical.

  4. Manufacture and Testing of a High Field Gradient Magnetic Fractionation System for Quantitative Detection of Plasmodium falciparum Gametocytes

    NASA Astrophysics Data System (ADS)

    Karl, Stephan; Woodward, Robert C.; Davis, Timothy M. E.; St. Pierre, Tim G.

    2010-12-01

    Plasmodium falciparum is the most dangerous of the human malaria parasite species and accounts for millions of clinical episodes of malaria each year in tropical countries. The pathogenicity of Plasmodium falciparum is a result of its ability to infect erythrocytes where it multiplies asexually over 48 h or develops into sexual forms known as gametocytes. If sufficient male and female gametocytes are taken up by a mosquito vector, it becomes infectious. Therefore, the presence and density of gametocytes in human blood is an important indicator of human-to-mosquito transmission of malaria. Recently, we have shown that high field gradient magnetic fractionation improves gametocyte detection in human blood samples. Here we present two important new developments. Firstly we introduce a quantitative approach to replace the previous qualitative method and, secondly, we describe a novel method that enables cost-effective production of the magnetic fractionation equipment required to carry out gametocyte quantification. We show that our custom-made magnetic fractionation equipment can deliver results with similar sensitivity and convenience but for a small fraction of the cost.

  5. Fatigue and failure responses of lead zirconate titanate multilayer actuator under unipolar high-field electric cycling

    NASA Astrophysics Data System (ADS)

    Zeng, Fan Wen; Wang, Hong; Lin, Hua-Tay

    2013-07-01

    Lead zirconate titanate (PZT) multilayer actuators with an interdigital electrode design were studied under high electric fields (3 and 6 kV/mm) in a unipolar cycling mode. A 100 Hz sine wave was used in cycling. Five specimens tested under 6 kV/mm failed from 3.8 × 105 to 7 × 105 cycles, whereas three other specimens tested under 3 kV/mm were found to be still functional after 108 cycles. Variations in piezoelectric and dielectric responses of the tested specimens were observed during the fatigue test, depending on the measuring and cycling conditions. Selected fatigued and damaged actuators were characterized using an impedance analyzer or small signal measurement. Furthermore, involved fatigue and failure mechanisms were investigated using scanning acoustic microscope and scanning electron microscope. The extensive cracks and porous regions were revealed across the PZT layers on the cross sections of a failed actuator. The results from this study have demonstrated that the high-field cycling can accelerate the fatigue of PZT stacks as long as the partial discharge is controlled. The small signal measurement can also be integrated into the large signal measurement to characterize the fatigue response of PZT stacks in a more comprehensive basis. The former can further serve as an experimental method to test and monitor the behavior of PZT stacks.

  6. Decoding the direction of imagined visual motion using 7 T ultra-high field fMRI

    PubMed Central

    Emmerling, Thomas C.; Zimmermann, Jan; Sorger, Bettina; Frost, Martin A.; Goebel, Rainer

    2016-01-01

    There is a long-standing debate about the neurocognitive implementation of mental imagery. One form of mental imagery is the imagery of visual motion, which is of interest due to its naturalistic and dynamic character. However, so far only the mere occurrence rather than the specific content of motion imagery was shown to be detectable. In the current study, the application of multi-voxel pattern analysis to high-resolution functional data of 12 subjects acquired with ultra-high field 7 T functional magnetic resonance imaging allowed us to show that imagery of visual motion can indeed activate the earliest levels of the visual hierarchy, but the extent thereof varies highly between subjects. Our approach enabled classification not only of complex imagery, but also of its actual contents, in that the direction of imagined motion out of four options was successfully identified in two thirds of the subjects and with accuracies of up to 91.3% in individual subjects. A searchlight analysis confirmed the local origin of decodable information in striate and extra-striate cortex. These high-accuracy findings not only shed new light on a central question in vision science on the constituents of mental imagery, but also show for the first time that the specific sub-categorical content of visual motion imagery is reliably decodable from brain imaging data on a single-subject level. PMID:26481673

  7. Functionality of veterinary identification microchips following low- (0.5 tesla) and high-field (3 tesla) magnetic resonance imaging.

    PubMed

    Piesnack, Susann; Frame, Mairi E; Oechtering, Gerhard; Ludewig, Eberhard

    2013-01-01

    The ability to read patient identification microchips relies on the use of radiofrequency pulses. Since radiofrequency pulses also form an integral part of the magnetic resonance imaging (MRI) process, the possibility of loss of microchip function during MRI scanning is of concern. Previous clinical trials have shown microchip function to be unaffected by MR imaging using a field strength of 1 Tesla and 1.5. As veterinary MRI scanners range widely in field strength, this study was devised to determine whether exposure to lower or higher field strengths than 1 Tesla would affect the function of different types of microchip. In a phantom study, a total of 300 International Standards Organisation (ISO)-approved microchips (100 each of three different types: ISO FDX-B 1.4 × 9 mm, ISO FDX-B 2.12 × 12 mm, ISO HDX 3.8 × 23 mm) were tested in a low field (0.5) and a high field scanner (3.0 Tesla). A total of 50 microchips of each type were tested in each scanner. The phantom was composed of a fluid-filled freezer pack onto which a plastic pillow and a cardboard strip with affixed microchips were positioned. Following an MRI scan protocol simulating a head study, all of the microchips were accurately readable. Neither 0.5 nor 3 Tesla imaging affected microchip function in this study.

  8. Electron localization effects on the low-temperature high-field magnetoresistivity of three-dimensional amorphous superconductors

    NASA Astrophysics Data System (ADS)

    Samoilov, A. V.; Yeh, N.-C.; Tsuei, C. C.

    1998-01-01

    The electrical resistivity ρ of three-dimensional amorphous superconducting films a-Mo3Si and a-Nb3Ge is measured in magnetic fields μ0H up to 30 T. At low temperatures and at magnetic fields above the upper critical field Hc2, ρ is temperature independent and decreases as a function of magnetic field. This field dependence is consistent with localization theory in the high-field limit [μ0H>>ħ/(4eL2φ), where Lφ is the phase-coherence length]. Above the superconducting transition temperature Tc, the temperature dependence of the conductivity is consistent with inelastic scattering processes which are destructive to the phase coherence for electron localization, thereby allowing estimates for Lφ(T). The Hall effect data on a-Mo3Si, in conjunction with the resistivity data, allow the determination of the carrier concentration and mean free path. The upper critical field is comparable to (in a-Mo3Si) and significantly larger than (in a-Nb3Ge) the Clogston-Chandrasekhar paramagnetic limit. This phenomenon is discussed in the context of electron localization.

  9. First observation of amino acid side chain dynamics in membrane proteins using high field deuterium nuclear magnetic resonance spectroscopy

    SciTech Connect

    Kinsey, R.A.; Kintanar, A.; Tsai, M.D.; Smith, R.L.; Janes, N.; Oldfield, E.

    1981-05-10

    The first deuterium NMR spectra of an individual membrane protein, bacteriohodopsin in the purple membrane of Halobacterium halobium R1 has been obtained. Biosynthetic isotopic enrichment with (gamma-2H6) valine and high field Fourier transform operation permitted rapid data acquisition on intact membranes, including measurement of relaxation times. At some temperatures high quality spectra could be obtained in less than 1 s. (U-14C)Valine tracer studies indicate that less than or equal to 2% of valine added to the growth medium is broken down and incorporated into other membrane constituents. The NMR results indicate that the valine side chain is a rather rigid structure. Motion about C alpha-C beta is slow (less than 10(5) s-1) at growth temperature, while motion about C beta-C gamma is as expected fast (much greater than 10(5) s-1) at all accessible temperatures. The activation energy for methyl group rotation from spin-lattice relaxation data between -75 and 53 degrees C is approximately 2.4 kcal/mol, in good agreement with previous 1H NMR studies on solid alkanes. Preliminary data on (gamma-2H6)valine-labeled Acholeplasma laidlawii B (PG9) cell membranes are also presented. Results strongly suggest that it should now be possible to observe in great detail the motions of any type of amino acid side chain in membrane proteins, including the effects of lipid composition on protein dynamics.

  10. Analysis of paralytic shellfish toxins using high-field asymmetric waveform ion mobility spectrometry with liquid chromatography-mass spectrometry.

    PubMed

    Beach, Daniel G; Melanson, Jeremy E; Purves, Randy W

    2015-03-01

    The analysis of paralytic shellfish toxins (PSTs) by liquid chromatography-mass spectrometry remains a challenge because of their high polarity, large number of analogues and the complex matrix in which they occur. Here we investigate the potential utility of high-field asymmetric waveform ion mobility spectrometry (FAIMS) as a gas-phase ion separation tool for analysis of PSTs by mass spectrometry. We investigate the separation of PSTs using FAIMS with two divergent goals: using FAIMS as a primary separation tool for rapid screening by electrospray ionization (ESI)-FAIMS-MS or combined with LC in a multidimensional LC-ESI-FAIMS-MS separation. First, a survey of the parameters that affect the sensitivity and selectivity of PST analysis by FAIMS was carried out using ESI-FAIMS-MS. In particular, the use of acetonitrile as a gas additive in the carrier gas flow offered good separation of all PST epimeric pairs. A second set of FAIMS conditions was also identified, which focussed PSTs to a relatively narrow CV range allowing development of an LC-ESI-FAIMS-MS method for analysis of PST toxins in complex mussel tissue extracts. The quantitative capabilities of this method were evaluated by analysing a PST containing mussel tissue matrix material. Results compared favourably with analysis by an established LC-post-column oxidation-fluorescence method with recoveries ranging from 70 to 106%, although sensitivity was somewhat reduced. The current work represents the first successful separation of PST isomers using ion mobility and shows the promise of FAIMS as a tool for analysis of algal biotoxins in complex samples and outlines some critical requirements for its future improvement.

  11. Relativistically Self-Channeled Femtosecond Terawatt Lasers for High-Field Physics and X-Ray Generation

    SciTech Connect

    Borisov, A.B.; Boyer, K.; Cameron, S.M.; Luk, T.S.; McPherson, A.; Nelson, T.; Rhodes, C.K.

    1999-01-01

    Optical channeling or refractive guiding processes involving the nonlinear interaction of intense femtosecond optical pulses with matter in the self-focussing regime has created exciting opportunities for next-generation laser plasma-based x-ray sources and directed energy applications. This fundamentally new form of extended paraxial electromagnetic propagation in nonlinear dispersive media such as underdense plasma is attributed to the interplay between normal optical diffraction and intensity-dependent nonlinear focussing and refraction contributions in the dielectric response. Superposition of these mechanisms on the intrinsic index profile acts to confine the propagating energy in a dynamic self-guiding longitudinal waveguide structure which is stable for power transmission and robust compression. The laser-driven channels are hypothesized to support a degree of solitonic transport behavior, simultaneously stable in the space and time domains (group velocity dispersion balances self-phase modulation), and are believed to be self-compensating for diffraction and dispersion over many Rayleigh lengths in contrast with the defining characteristics of conventional diffractive imaging and beamforming. By combining concentrated power deposition with well-ordered spatial localization, this phenomena will also create new possibilities for production and regulation of physical interactions, including electron beams, enhanced material coupling, and self-modulated plasma wakefields, over extended gain distances with unprecedented energy densities. Harmonious combination of short-pulse x-ray production with plasma channeling resulting from a relativistic charge displacement nonlinearity mechanism in the terawatt regime (10{sup 18} W/cm{sup 2}) has been shown to generate high-field conditions conducive to efficient multi-kilovolt x-ray amplification and peak spectral brightness. Channeled optical propagation with intense short-pulse lasers is expected to impact several

  12. Ultra-High Field MRI Post Mortem Structural Connectivity of the Human Subthalamic Nucleus, Substantia Nigra, and Globus Pallidus

    PubMed Central

    Plantinga, Birgit R.; Roebroeck, Alard; Kemper, Valentin G.; Uludağ, Kâmil; Melse, Maartje; Mai, Jürgen; Kuijf, Mark L.; Herrler, Andreas; Jahanshahi, Ali; ter Haar Romeny, Bart M.; Temel, Yasin

    2016-01-01

    Introduction: The subthalamic nucleus, substantia nigra, and globus pallidus, three nuclei of the human basal ganglia, play an important role in motor, associative, and limbic processing. The network of the basal ganglia is generally characterized by a direct, indirect, and hyperdirect pathway. This study aims to investigate the mesoscopic nature of these connections between the subthalamic nucleus, substantia nigra, and globus pallidus and their surrounding structures. Methods: A human post mortem brain specimen including the substantia nigra, subthalamic nucleus, and globus pallidus was scanned on a 7 T MRI scanner. High resolution diffusion weighted images were used to reconstruct the fibers intersecting the substantia nigra, subthalamic nucleus, and globus pallidus. The course and density of these tracks was analyzed. Results: Most of the commonly established projections of the subthalamic nucleus, substantia nigra, and globus pallidus were successfully reconstructed. However, some of the reconstructed fiber tracks such as the connections of the substantia nigra pars compacta to the other included nuclei and the connections with the anterior commissure have not been shown previously. In addition, the quantitative tractography approach showed a typical degree of connectivity previously not documented. An example is the relatively larger projections of the subthalamic nucleus to the substantia nigra pars reticulata when compared to the projections to the globus pallidus internus. Discussion: This study shows that ultra-high field post mortem tractography allows for detailed 3D reconstruction of the projections of deep brain structures in humans. Although the results should be interpreted carefully, the newly identified connections contribute to our understanding of the basal ganglia. PMID:27378864

  13. High-Field Asymmetric-Waveform Ion Mobility Spectrometry and Electron Detachment Dissociation of Isobaric Mixtures of Glycosaminoglycans

    NASA Astrophysics Data System (ADS)

    Kailemia, Muchena J.; Park, Melvin; Kaplan, Desmond A.; Venot, Andre; Boons, Geert-Jan; Li, Lingyun; Linhardt, Robert J.; Amster, I. Jonathan

    2013-11-01

    High-field asymmetric waveform ion mobility spectrometry (FAIMS) is shown to be capable of resolving isomeric and isobaric glycosaminoglycan negative ions and to have great utility for the analysis of this class of molecules when combined with Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) and tandem mass spectrometry. Electron detachment dissociation (EDD) and other ion activation methods for tandem mass spectrometry can be used to determine the sites of labile sulfate modifications and for assigning the stereochemistry of hexuronic acid residues of glycosaminoglycans (GAGs). However, mixtures with overlapping mass-to-charge values present a challenge, as their precursor species cannot be resolved by a mass analyzer prior to ion activation. FAIMS is shown to resolve two types of mass-to-charge overlaps. A mixture of chondroitin sulfate A (CSA) oligomers with 4-10 saccharides units produces ions of a single mass-to-charge by electrospray ionization, as the charge state increases in direct proportion to the degree of polymerization for these sulfated carbohydrates. FAIMS is shown to resolve the overlapping charge. A more challenging type of mass-to-charge overlap occurs for mixtures of diastereomers. FAIMS is shown to separate two sets of epimeric GAG tetramers. For the epimer pairs, the complexity of the separation is reduced when the reducing end is alkylated, suggesting that anomers are also resolved by FAIMS. The resolved components were activated by EDD and the fragment ions were analyzed by FTICR-MS. The resulting tandem mass spectra were able to distinguish the two epimers from each other.

  14. Nontarget analysis of Murchison soluble organic matter by high-field NMR spectroscopy and FTICR mass spectrometry.

    PubMed

    Hertkorn, N; Harir, M; Schmitt-Kopplin, Ph

    2015-09-01

    High-field NMR spectra of Murchison meteorite methanolic extracts revealed primarily aliphatic extraterrestrial organic matter (EOM) with near statistical branching of commonly C(3-5) units separated by heteroatoms and aromatic units. The ratios of CCH, OCH and C(sp2)H units were 89 : 8 : 3, whereas carbon-based aliphatic chain termination was in the order methyl >  -COOH >  -CH(CH3)COOH. Aliphatic methine carbon was abundant, but its weak NMR signatures were primarily deduced from JRES (J-resolved) NMR spectra. Carbon NMR spectra were dominated by methylene and methyl carbon; strong apodization revealed methine carbon, of which about 20% was aromatic. Extrapolation provided 5-7% aromatic carbon present in Murchison soluble EOM. Compositional heterogeneity in Murchison methanolic extracts was visible in NMR and Fourier transform ion cyclotron (FTICR) mass spectra obtained from a few cubic millimeters of solid Murchison meteorite; increasing sample size enhanced uniformity of NMR spectra. Intrinsic chemical diversity and pH-dependent chemical shift variance contributed to the disparity of NMR spectra. FTICR mass spectra provided distinct clustering of CHO/CHOS and CHNO/CHNOS molecular series and confirmed the prevalence of aliphatic/alicyclic (73%) over single aromatic (21%) and polyaromatic (6%) molecular compositions, suggesting extensive aliphatic substitution of aromatic units as proposed by NMR. Murchison soluble EOM molecules feature a center with enhanced aromatic and heteroatom content, which provides rather diffuse and weak NMR signatures resulting from a huge overall chemical diversity. The periphery of Murchison EOM molecules comprises flexible branched aliphatic chains and aliphatic carboxylic acids. These project on narrow ranges of chemical shift, facilitating observation in one-dimensional and two-dimensional NMR spectra. The conformational entropy provided by these flexible surface moieties facilitates the solubility of EOM. PMID

  15. Magnetic properties of Zn doped Co{sub 2}Y hexaferrite by using high-field Mössbauer spectroscopy

    SciTech Connect

    Tae Lim, Jung; Sung Kim, Chul

    2014-05-07

    The polycrystalline samples of Ba{sub 2}Co{sub 2−x}Zn{sub x}Fe{sub 12}O{sub 22} (x = 0.5, 1.0, 1.5) were synthesized by using solid-state-reaction method. From the XRD patterns, analyzed by Rietveld refinement, the prepared samples are found to be single-phased with rhombohedral structure (R-3m). The magnetic properties of samples were investigated with vibrating sample magnetometer, and high-field Mössbauer spectrometer. From the zero-field-cooled curves under 100 Oe between 4.2 and 740 K, we observe that the samples show spin transition from helicalmagnetic to ferrimagnetic order. With increasing Zn ion concentration, the spin transition temperature (T{sub s}) and Curie temperature (T{sub C}) decrease linearly. We have obtained Zero-field Mössbauer spectra of all samples at various temperatures ranging from 4.2 to 650 K, and analyzed the spectra below T{sub C} as six-sextets for Fe sites. From the temperature dependence of hyperfine field (H{sub hf}), we have noticed an abrupt change in H{sub hf} at T{sub s}. In addition, Mössbauer spectra of all samples at 4.2 K were taken with applied field ranging from 0 to 50 kOe, indicating the canting angle between applied field and H{sub hf} decreased with increasing Zn concentration.

  16. Nontarget analysis of Murchison soluble organic matter by high-field NMR spectroscopy and FTICR mass spectrometry.

    PubMed

    Hertkorn, N; Harir, M; Schmitt-Kopplin, Ph

    2015-09-01

    High-field NMR spectra of Murchison meteorite methanolic extracts revealed primarily aliphatic extraterrestrial organic matter (EOM) with near statistical branching of commonly C(3-5) units separated by heteroatoms and aromatic units. The ratios of CCH, OCH and C(sp2)H units were 89 : 8 : 3, whereas carbon-based aliphatic chain termination was in the order methyl >  -COOH >  -CH(CH3)COOH. Aliphatic methine carbon was abundant, but its weak NMR signatures were primarily deduced from JRES (J-resolved) NMR spectra. Carbon NMR spectra were dominated by methylene and methyl carbon; strong apodization revealed methine carbon, of which about 20% was aromatic. Extrapolation provided 5-7% aromatic carbon present in Murchison soluble EOM. Compositional heterogeneity in Murchison methanolic extracts was visible in NMR and Fourier transform ion cyclotron (FTICR) mass spectra obtained from a few cubic millimeters of solid Murchison meteorite; increasing sample size enhanced uniformity of NMR spectra. Intrinsic chemical diversity and pH-dependent chemical shift variance contributed to the disparity of NMR spectra. FTICR mass spectra provided distinct clustering of CHO/CHOS and CHNO/CHNOS molecular series and confirmed the prevalence of aliphatic/alicyclic (73%) over single aromatic (21%) and polyaromatic (6%) molecular compositions, suggesting extensive aliphatic substitution of aromatic units as proposed by NMR. Murchison soluble EOM molecules feature a center with enhanced aromatic and heteroatom content, which provides rather diffuse and weak NMR signatures resulting from a huge overall chemical diversity. The periphery of Murchison EOM molecules comprises flexible branched aliphatic chains and aliphatic carboxylic acids. These project on narrow ranges of chemical shift, facilitating observation in one-dimensional and two-dimensional NMR spectra. The conformational entropy provided by these flexible surface moieties facilitates the solubility of EOM.

  17. Comet formation

    NASA Astrophysics Data System (ADS)

    Blum, J.

    2014-07-01

    There has been vast progress in our understanding of planetesimal formation over the past decades, owing to a number of laboratory experiments as well as to refined models of dust and ice agglomeration in protoplanetary disks. Coagulation rapidly forms cm-sized ''pebbles'' by direct sticking in collisions at low velocities (Güttler et al. 2010; Zsom et al. 2010). For the further growth, two model approaches are currently being discussed: (1) Local concentration of pebbles in nebular instabilities until gravitational instability occurs (Johansen et al. 2007). (2) A competition between fragmentation and mass transfer in collisions among the dusty bodies, in which a few ''lucky winners'' make it to planetesimal sizes (Windmark et al. 2012a,b; Garaud et al. 2013). Predictions of the physical properties of the resulting bodies in both models allow a distinction of the two formation scenarios of planetesimals. In particular, the tensile strength (i.e, the inner cohesion) of the planetesimals differ widely between the two models (Skorov & Blum 2012; Blum et al. 2014). While model (1) predicts tensile strengths on the order of ˜ 1 Pa, model (2) results in rather compactified dusty bodies with tensile strengths in the kPa regime. If comets are km-sized survivors of the planetesimal-formation era, they should in principle hold the secret of their formation process. Water ice is the prime volatile responsible for the activity of comets. Thermophysical models of the heat and mass transport close to the comet-nucleus surface predict water-ice sublimation temperatures that relate to maximum sublimation pressures well below the kPa regime predicted for formation scenario (2). Model (1), however, is in agreement with the observed dust and gas activity of comets. Thus, a formation scenario for cometesimals involving gravitational instability is favored (Blum et al. 2014).

  18. Planet Formation

    NASA Astrophysics Data System (ADS)

    Klahr, Hubert; Brandner, Wolfgang

    2011-02-01

    1. Historical notes on planet formation Bodenheimer; 2. The formation and evolution of planetary systems Bouwman et al.; 3. Destruction of protoplanetary disks by photoevaporation Richling, Hollenbach and Yorke; 4. Turbulence in protoplanetary accretion disks Klahr, Rozyczka, Dziourkevitch, Wunsch and Johansen; 5. The origin of solids in the early solar system Trieloff and Palme; 6. Experiments on planetesimal formation Wurm and Blum; 7. Dust coagulation in protoplanetary disks Henning, Dullemond, Wolf and Dominik; 8. The accretion of giant planet cores Thommes and Duncan; 9. Planetary transits: direct vision of extrasolar planets Lecavelier des Etangs and Vidal-Madjar; 10. The core accretion - gas capture model Hubickyj; 11. Properties of exoplanets Marcy, Fischer, Butler and Vogt; 12. Giant planet formation: theories meet observations Boss; 13. From hot Jupiters to hot Neptures … and below Lovis, Mayor and Udry; 14. Disk-planet interaction and migration Masset and Kley; 15. The Brown Dwarf - planet relation Bate; 16. From astronomy to astrobiology Brandner; 17. Overview and prospective Lin.

  19. ECG-based gating in ultra high field cardiovascular magnetic resonance using an independent component analysis approach

    PubMed Central

    2013-01-01

    Background In Cardiovascular Magnetic Resonance (CMR), the synchronization of image acquisition with heart motion is performed in clinical practice by processing the electrocardiogram (ECG). The ECG-based synchronization is well established for MR scanners with magnetic fields up to 3 T. However, this technique is prone to errors in ultra high field environments, e.g. in 7 T MR scanners as used in research applications. The high magnetic fields cause severe magnetohydrodynamic (MHD) effects which disturb the ECG signal. Image synchronization is thus less reliable and yields artefacts in CMR images. Methods A strategy based on Independent Component Analysis (ICA) was pursued in this work to enhance the ECG contribution and attenuate the MHD effect. ICA was applied to 12-lead ECG signals recorded inside a 7 T MR scanner. An automatic source identification procedure was proposed to identify an independent component (IC) dominated by the ECG signal. The identified IC was then used for detecting the R-peaks. The presented ICA-based method was compared to other R-peak detection methods using 1) the raw ECG signal, 2) the raw vectorcardiogram (VCG), 3) the state-of-the-art gating technique based on the VCG, 4) an updated version of the VCG-based approach and 5) the ICA of the VCG. Results ECG signals from eight volunteers were recorded inside the MR scanner. Recordings with an overall length of 87 min accounting for 5457 QRS complexes were available for the analysis. The records were divided into a training and a test dataset. In terms of R-peak detection within the test dataset, the proposed ICA-based algorithm achieved a detection performance with an average sensitivity (Se) of 99.2%, a positive predictive value (+P) of 99.1%, with an average trigger delay and jitter of 5.8 ms and 5.0 ms, respectively. Long term stability of the demixing matrix was shown based on two measurements of the same subject, each being separated by one year, whereas an averaged detection

  20. Theory of electron emission in high fields from atomically sharp emitters: Validity of the Fowler-Nordheim equation

    NASA Astrophysics Data System (ADS)

    Cutler, P. H.; He, Jun; Miller, J.; Miskovsky, N. M.; Weiss, B.; Sullivan, T. E.

    1993-04-01

    Field emission from metallic emitters is generally described by the Fowler-Nordheim [F-N] theory, which is based on a planar model of the tip with a classical image correction. Within the free electron model and the WKB approximation, the planar tip model leads to the well-known Fowler-Nordheim equation, which predicts that a plot of log J/F 2 versus 1/F, where J is the current density and F, the field, should be a straight line within the narrow range of field strengths of typical field emission experiments, 3 - 5V/nm. This has been experimentally confirmed for conventional emitters, (i.e., electrolytically etched tips with radii ⪆50 nm). Field emitters fabricated with today's new techniques are much sharper with radii of curvature of the order of nm's or even the size of a single atom. Hence, the local geometry of the tip may become an important factor in the electron emission process. To investigate the effects of the shape and/or size on emission, the authors, in a recent series of papers, studied the dependence of the current-voltage characteristics on the local geometry of pointed emitters. It was found that the calculated results, plotted as log J/V 2 vs. 1/V, do not exhibit the straight line behavior predicted by the Fowler-Nordheim theory. In addition, there is a dramatic increase in the tunneling current for a fixed external bias, V, relative to the Fowler-Nordheim result for a planar model of the tip with the same bias voltage. Using the exact current integral additional results have been obtained exhibiting the effects of emitter curvature on field electron energy distributions and on electron emission in high fields and temperatures. These results continue to differ with the predictions of the Fowler-Nordheim equation for the same emitter models. Therefore, the adequacy of a β-factor in the conventional planar model Fowler-Nordheim equation to account for emitter curvature is examined. It is demonstrated that even a β-modified Fowler

  1. Equilibrium drives of the low and high field side n = 2 plasma response and impact on global confinement

    DOE PAGES

    Paz-Soldan, C.; Logan, N. C.; Haskey, S. R.; Nazikian, R.; Strait, E. J.; Chen, X.; Ferraro, N. M.; King, J. D.; Lyons, B. C.; Park, J. -K.

    2016-03-31

    The nature of the multi-modal n=2 plasma response and its impact on global confinement is studied as a function of the axisymmetric equilibrium pressure, edge safety factor, collisionality, and L-versus H-mode conditions. Varying the relative phase (ΔΦUL) between upper and lower in-vessel coils demonstrates that different n=2 poloidal spectra preferentially excite different plasma responses. These different plasma response modes are preferentially detected on the tokamak high-field side (HFS) or low-field side (LFS) midplanes, have different radial extents, couple differently to the resonant surfaces, and have variable impacts on edge stability and global confinement. In all equilibrium conditions studied, the observedmore » confinement degradation shares the same ΔΦUL dependence as the coupling to the resonant surfaces given by both ideal (IPEC) and resistive (MARS-F) MHD computation. Varying the edge safety factor shifts the equilibrium field-line pitch and thus the ΔΦUL dependence of both the global confinement and the n=2 magnetic response. As edge safety factor is varied, modeling finds that the HFS response (but not the LFS response), the resonant surface coupling, and the edge displacements near the X-point all share the same ΔΦUL dependence. The LFS response magnitude is strongly sensitive to the core pressure and is insensitive to the collisionality and edge safety factor. This indicates that the LFS measurements are primarily sensitive to a pressure-driven kink-ballooning mode that couples to the core plasma. MHD modeling accurately reproduces these (and indeed all) LFS experimental trends and supports this interpretation. In contrast to the LFS, the HFS magnetic response and correlated global confinement impact is unchanged with plasma pressure, but is strongly reduced in high collisionality conditions in both H- and L-mode. This experimentally suggests the bootstrap current drives the HFS response through the kink-peeling mode drive, though

  2. The Scaling Rule and Fluxon Core Pinning in a High-Field Superconductor with Artificially Introduced Pins

    NASA Astrophysics Data System (ADS)

    Cooley, Lance David

    Flux pinning affects virtually every aspect of high-field superconductivity. Its fundamental mechanism(s) are in principle derived from a complicated theory, but are in practice generally accessed through measuring the field dependence of the bulk flux pinning force (F _{p}(B)). The central piece of information is the shape of the F_{p }(B) curve: It is generally accepted that if, and only if, the curve's shape is constant while the temperature or pin dimension changes, one pinning mechanism is dominant (the 'scaling rule'). During the course of this thesis, we established that the shape of F_{p}(B) is affected by the statistical distribution of the elementary pinning forces (f_{p}). Contrary to prior beliefs, it was concluded that the shape of the bulk pinning force curve for fluxon core pinning is constant, when the distribution is broad, only if the microstructure is fractal. The peak of the F_ {p}(B) curve occurs at a lower field prior models predict, regardless of whether the shape of the curve is constant. When the distribution is narrow, a constant shape occurs, and has the shape predicted for core pinning and direct summation. Thus, the bulk pinning force curve and the elementary pinning mechanism are directly related by the scaling rule only when the f_ {p} distribution is narrow. Within this context, core pinning has been investigated with a specially fabricated Nb-Ti composite having artificially introduced pins, for which the f_{p } distribution is as narrow as can be made. By design, core pinning should be dominant; the shape of the F_{p}(B) curve does not, however, have the predicted form. The results can be explained by a new pinning mechanism, which incorporates the proximity effect and an anisotropic fluxon core, as proposed by Gurevich. It is concluded that the shape of the bulk pinning force curve is very sensitive to the proximity effect, and it can have a peak at a higher field than was previously thought possible for core pinning. The scaling

  3. Progressive Supranuclear Palsy: High-Field-Strength MR Microscopy in the Human Substantia Nigra and Globus Pallidus

    PubMed Central

    Foroutan, Parastou; Murray, Melissa E.; Fujioka, Shinsuke; Schweitzer, Katherine J.; Dickson, Dennis W.; Wszolek, Zbigniew K.

    2013-01-01

    Purpose: To characterize changes in the magnetic resonance (MR) relaxation properties of progressive supranuclear palsy (PSP) and tissue from neurologically normal brains by using high-resolution (21.1-T, 900-MHz) MR microscopy of postmortem human midbrain and basal ganglia. Materials and Methods: This HIPAA-compliant study was approved by the institutional review board at the Mayo Clinic and informed consent was obtained. Postmortem tissue from age-matched PSP (n = 6) and control (n = 3) brains was imaged by using three-dimensional fast low-angle shot MR imaging with isotropic resolution of 50 μm. Relaxation times and parametric relaxation maps were generated from spin-echo and gradient-recalled-echo sequences. MR findings were correlated with histologic features by evaluating the presence of iron by using Prussian blue and ferritin and microglia burden as determined by a custom-designed color deconvolution algorithm. T2 and T2*, signal intensities, percent pixels (that could not be fitted in a pixel-by-pixel regression analysis due to severe hypointensity), and histologic data (total iron, ferritin, and microglia burden) were statistically analyzed by using independent sample t tests (P < .05). Results: PSP specimens showed higher iron burden in the cerebral peduncles and substantia nigra than did controls. However, only the putamen was significantly different, and it correlated with a decrease of T2* compared with controls (−48%; P = .043). Similarly, substantia nigra showed a significant decrease of T2* signal in PSP compared with controls (−57%; P = .028). Compared with controls, cerebral peduncles showed increased T2 (38%; P = .026) and T2* (34%; P = .014), as well as higher T2 signal intensity (57%; P = .049). Ferritin immunoreactivity was the opposite from iron burden and was significantly lower compared with controls in the putamen (−74%; P = .025), red nucleus (−61%; P = .018), and entire basal ganglia section (−63%; P = .016). Conclusion: High-field

  4. Flow and kinematics of partially molten continental crust measured by both low- and high-field AMS

    NASA Astrophysics Data System (ADS)

    Teyssier, C.; Ferre, E.; Martin-Hernandez, F.

    2002-12-01

    There is considerable debate about the flow of the partially molten mid- to lower continental crust during orogenic deformation. Geologic observations of migmatite terrains suggest that deformation of orogenic crust is controlled by both horizontal flow, leading to layered migmatite, and vertical flow, reflecting the emplacement of gneiss domes cored by migmatite. Lateral flow of the mid- to lower crust has been described by the popular channel-flow model, and vertical flow is driven by gravitational instabilities. Unfortunately, fabrics in migmatites are difficult to unravel due to pervasive, high-temperature recrystallization. Planar fabrics such as migmatitic banding, layering, or foliation, are usually preserved macroscopically, but lineations are commonly unclear. Therefore, the petrofabric analysis of migmatites, including the definition of sense of shear, is problematic. We have developed a new structural methodology for the study of migmatite based on the anisotropy of magnetic susceptibility (AMS) combined with image analysis. Our results on Archean migmatites of the Minnesota River Valley establish this method as a powerful petrofabric tool. Dimension stone quarries provide ideal sampling sites. The migmatites are coarse grained, granitic to tonalitic in composition and display a centimeter scale compositional layering. The layering and the regional foliation are subhorizontal to shallowly dipping to the NE. Mineral lineations are largely not observable. Low-field magnetism is carried mainly by primary multidomain magnetite grains ranging 20-200 microns in size. The magnetic susceptibilities are generally high, around 5000 to 10000 10-6 SI. The degree of magnetic anisotropy is large, between 1.2 and 1.3. The principal axes of the low-field AMS ellipsoid coincide with those defined by the foliation, and the magnetic lineation is consistently oriented E-W; the degree of anisotropy is broadly correlated with mineral fabric intensity. In high-field (HF = 1

  5. Galaxy formation.

    PubMed

    Peebles, P J

    1998-01-01

    It is argued that within the standard Big Bang cosmological model the bulk of the mass of the luminous parts of the large galaxies likely had been assembled by redshift z approximately 10. Galaxy assembly this early would be difficult to fit in the widely discussed adiabatic cold dark matter model for structure formation, but it could agree with an isocurvature version in which the cold dark matter is the remnant of a massive scalar field frozen (or squeezed) from quantum fluctuations during inflation. The squeezed field fluctuations would be Gaussian with zero mean, and the distribution of the field mass therefore would be the square of a random Gaussian process. This offers a possibly interesting new direction for the numerical exploration of models for cosmic structure formation.

  6. Galaxy formation

    PubMed Central

    Peebles, P. J. E.

    1998-01-01

    It is argued that within the standard Big Bang cosmological model the bulk of the mass of the luminous parts of the large galaxies likely had been assembled by redshift z ∼ 10. Galaxy assembly this early would be difficult to fit in the widely discussed adiabatic cold dark matter model for structure formation, but it could agree with an isocurvature version in which the cold dark matter is the remnant of a massive scalar field frozen (or squeezed) from quantum fluctuations during inflation. The squeezed field fluctuations would be Gaussian with zero mean, and the distribution of the field mass therefore would be the square of a random Gaussian process. This offers a possibly interesting new direction for the numerical exploration of models for cosmic structure formation. PMID:9419326

  7. Electron-mediating Cu(A) centers in proteins: a comparative high field (1)H ENDOR study.

    PubMed

    Epel, Boris; Slutter, Claire S; Neese, Frank; Kroneck, Peter M H; Zumft, Walter G; Pecht, Israel; Farver, Ole; Lu, Yi; Goldfarb, Daniella

    2002-07-10

    High field (W-band, 95 GHz) pulsed electron-nuclear double resonance (ENDOR) measurements were carried out on a number of proteins that contain the mixed-valence, binuclear electron-mediating Cu(A) center. These include nitrous oxide reductase (N(2)OR), the recombinant water-soluble fragment of subunit II of Thermus thermophilus cytochrome c oxidase (COX) ba(3) (M160T9), its M160QT0 mutant, where the weak axial methionine ligand has been replaced by a glutamine, and the engineered "purple" azurin (purpAz). The three-dimensional (3-D) structures of these proteins, apart from the mutant, are known. The EPR spectra of all samples showed the presence of a mononuclear Cu(II) impurity with EPR characteristics of a type II copper. At W-band, the g( perpendicular) features of this center and of Cu(A) are well resolved, thus allowing us to obtain a clean Cu(A) ENDOR spectrum. The latter consists of two types of ENDOR signals. The first includes the signals of the four strongly coupled cysteine beta-protons, with isotropic hyperfine couplings, A(iso), in the 7-15 MHz range. The second group consists of weakly coupled protons with a primarily anisotropic character with A(zz) < 3 MHz. Orientation selective ENDOR spectra were collected for N(2)OR, M160QT0, and purpAz, and simulations of the cysteine beta-protons signals provided their isotropic and anisotropic hyperfine interactions. A linear correlation with a negative slope was found between the maximum A(iso) value of the beta-protons and the copper hyperfine interaction. Comparison of the best-fit anisotropic hyperfine parameters with those calculated from dipolar interactions extracted from the available 3-D structures sets limit to the sulfur spin densities. Similarly, the small coupling spectral region was simulated on the basis of the 3-D structures and compared with the experimental spectra. It was found that the width of the powder patterns of the weakly coupled protons recorded at g(perpendicular) is mainly

  8. High field (9.4 Tesla) magnetic resonance imaging of cortical grey matter lesions in multiple sclerosis.

    PubMed

    Schmierer, Klaus; Parkes, Harold G; So, Po-Wah; An, Shu F; Brandner, Sebastian; Ordidge, Roger J; Yousry, Tarek A; Miller, David H

    2010-03-01

    .9; SD = 5 versus 22.6 ms; SD = 4.7; P < 0.01). Associations were detected between phosphorylated neurofilament and myelin basic protein (r = 0.58, P < 0.01), myelin basic protein and T(2) (r = -0.59, P < 0.01), and neuronal density and T(1) (r = -0.57, P < 0.01). All indices correlated with duration of tissue fixation, however, including the latter in the analysis did not fundamentally affect the associations described. Our data show that T(2)-weighted magnetic resonance imaging at 9.4 T enables detection of cortical grey matter lesion in post-mortem multiple sclerosis brain. The quantitative associations suggest that in cortical grey matter T(1) may be a predictor of neuronal density, and T(2) of myelin content (and-secondarily-axons). Successful translation of these results into in vivo studies using high field magnetic resonance imaging (e.g. 3 T and 7 T) will improve the assessment of cortical pathology and thereby have an impact on the diagnosis and natural history studies of patients with multiple sclerosis, as well as clinical trial designs for putative treatments to prevent cortical demyelination and neuronal loss.

  9. Amphiplex Formation

    NASA Astrophysics Data System (ADS)

    Petersen, Shannon; Laaser, Jennifer; Lodge, Timothy

    2015-03-01

    Polymer-micelle complexes are currently under heavy investigation due to their potential applications in targeted drug delivery and gene therapy, yet the dynamics of the complex formation is still relatively unstudied. By varying the ratios of poly(styrene sulfonate) chains and cationic poly(dimethylaminoethyl methacrylate)-b-poly(styrene) micelles and the ionic strength of the system, we created a variety of complex configurations of different sizes and charges. The complexes were characterized dynamic light scattering and zeta potential measurements which provided information regarding the hydrodynamic radius, distribution of sizes, and effective charge.

  10. Low temperature and high field regimes of connected kagome artificial spin ice: the role of domain wall topology

    NASA Astrophysics Data System (ADS)

    Zeissler, Katharina; Chadha, Megha; Lovell, Edmund; Cohen, Lesley F.; Branford, Will R.

    2016-07-01

    Artificial spin ices are frustrated magnetic nanostructures where single domain nanobars act as macrosized spins. In connected kagome artificial spin ice arrays, reversal occurs along one-dimensional chains by propagation of ferromagnetic domain walls through Y-shaped vertices. Both the vertices and the walls are complex chiral objects with well-defined topological edge-charges. At room temperature, it is established that the topological edge-charges determine the exact switching reversal path taken. However, magnetic reversal at low temperatures has received much less attention and how these chiral objects interact at reduced temperature is unknown. In this study we use magnetic force microscopy to image the magnetic reversal process at low temperatures revealing the formation of quite remarkable high energy remanence states and a change in the dynamics of the reversal process. The implication is the breakdown of the artificial spin ice regime in these connected structures at low temperatures.

  11. Low temperature and high field regimes of connected kagome artificial spin ice: the role of domain wall topology.

    PubMed

    Zeissler, Katharina; Chadha, Megha; Lovell, Edmund; Cohen, Lesley F; Branford, Will R

    2016-01-01

    Artificial spin ices are frustrated magnetic nanostructures where single domain nanobars act as macrosized spins. In connected kagome artificial spin ice arrays, reversal occurs along one-dimensional chains by propagation of ferromagnetic domain walls through Y-shaped vertices. Both the vertices and the walls are complex chiral objects with well-defined topological edge-charges. At room temperature, it is established that the topological edge-charges determine the exact switching reversal path taken. However, magnetic reversal at low temperatures has received much less attention and how these chiral objects interact at reduced temperature is unknown. In this study we use magnetic force microscopy to image the magnetic reversal process at low temperatures revealing the formation of quite remarkable high energy remanence states and a change in the dynamics of the reversal process. The implication is the breakdown of the artificial spin ice regime in these connected structures at low temperatures.

  12. Low temperature and high field regimes of connected kagome artificial spin ice: the role of domain wall topology.

    PubMed

    Zeissler, Katharina; Chadha, Megha; Lovell, Edmund; Cohen, Lesley F; Branford, Will R

    2016-01-01

    Artificial spin ices are frustrated magnetic nanostructures where single domain nanobars act as macrosized spins. In connected kagome artificial spin ice arrays, reversal occurs along one-dimensional chains by propagation of ferromagnetic domain walls through Y-shaped vertices. Both the vertices and the walls are complex chiral objects with well-defined topological edge-charges. At room temperature, it is established that the topological edge-charges determine the exact switching reversal path taken. However, magnetic reversal at low temperatures has received much less attention and how these chiral objects interact at reduced temperature is unknown. In this study we use magnetic force microscopy to image the magnetic reversal process at low temperatures revealing the formation of quite remarkable high energy remanence states and a change in the dynamics of the reversal process. The implication is the breakdown of the artificial spin ice regime in these connected structures at low temperatures. PMID:27443523

  13. Low temperature and high field regimes of connected kagome artificial spin ice: the role of domain wall topology

    PubMed Central

    Zeissler, Katharina; Chadha, Megha; Lovell, Edmund; Cohen, Lesley F.; Branford, Will R.

    2016-01-01

    Artificial spin ices are frustrated magnetic nanostructures where single domain nanobars act as macrosized spins. In connected kagome artificial spin ice arrays, reversal occurs along one-dimensional chains by propagation of ferromagnetic domain walls through Y-shaped vertices. Both the vertices and the walls are complex chiral objects with well-defined topological edge-charges. At room temperature, it is established that the topological edge-charges determine the exact switching reversal path taken. However, magnetic reversal at low temperatures has received much less attention and how these chiral objects interact at reduced temperature is unknown. In this study we use magnetic force microscopy to image the magnetic reversal process at low temperatures revealing the formation of quite remarkable high energy remanence states and a change in the dynamics of the reversal process. The implication is the breakdown of the artificial spin ice regime in these connected structures at low temperatures. PMID:27443523

  14. Oxidative mobilization of cerium and uranium and enhanced release of "immobile" high field strength elements from igneous rocks in the presence of the biogenic siderophore desferrioxamine B

    NASA Astrophysics Data System (ADS)

    Kraemer, Dennis; Kopf, Sebastian; Bau, Michael

    2015-09-01

    Polyvalent trace elements such as the high field strength elements (HFSE) are commonly considered rather immobile during low-temperature water-rock interaction. Hence, they have become diagnostic tools that are widely applied in geochemical studies. We present results of batch leaching experiments focused on the mobilization of certain HFSE (Y, Zr, Hf, Th, U and rare earth elements) from mafic, intermediate and felsic igneous rocks in the presence and absence, respectively, of the siderophore desferrioxamine B (DFOB). Our data show that DFOB strongly enhances the mobility of these trace elements during low-temperature water-rock interaction. The presence of DFOB produces two distinct features in the Rare Earths and Yttrium (REY) patterns of leaching solutions, regardless of the mineralogical and chemical composition or the texture of the rock type studied. Bulk rock-normalized REY patterns of leaching solutions with DFOB show (i) a very distinct positive Ce anomaly and (ii) depletion of La and other light REY relative to the middle REY, with a concave downward pattern between La and Sm. These features are not observed in experiments with hydrochloric acid, acetic acid or deionized water. In DFOB-bearing leaching solutions Ce and U are decoupled from and selectively enriched relative to light REY and Th, respectively, due to oxidation to Ce(IV) and U(VI). Oxidation of Ce3+ and U4+ is promoted by the significantly higher stability of the Ce(IV) and U(VI) DFOB complexes as compared to the Ce(III) and U(IV) DFOB complexes. This is similar to the relationship between the Ce(IV)- and Ce(III)-pentacarbonate complexes that cause positive Ce anomalies in alkaline lakes. However, while formation of Ce(IV) carbonate complexes is confined to alkaline environments, Ce(IV) DFOB complexes may produce positive Ce anomalies even in mildly acidic and near-neutral natural waters. Siderophore-promoted dissolution processes also significantly enhance mobility of other 'immobile' HFSE

  15. New 30 kA power system at Fermilab and its use for measuring the effects of ripple current on the performance of superconducting high field magnets

    SciTech Connect

    Carcagno, R.; Feher, S.; Garvey, J.; Jaskierny, W.; Lamm, M.; Makulski, A.; Orris, D.F.; Pfeffer, H.; Tartaglia, M.; Tompkins, J.; Wolff, D.; /Fermilab

    2004-12-01

    A new 30 kA, 30 V dc Power System was designed, built, and commissioned at Fermilab for testing Superconducting High Field Magnets. This system has been successfully supporting operations at the Fermilab Magnet Test Facility since April 2002. It is based on six commercial 150 kW Power Energy Industries power supply modules and the following in-house modules: six 720 Hz filters, two 15 kA/1kV dc solid-state dump switch, and a 3 MJ/30 kA/1 kV dc dump resistor. Additional inhouse electronic components were designed and built to provide precise current regulation and distribution of current and current rate of change. An industrial-type Programmable Logic Controller system was used to provide equipment interlocks and monitoring. This paper summarizes studies on the influence of characteristics of this new power system--such as ripple current--on the performance of High Field Superconducting magnets.

  16. Investigation of Mechanical Activation on Li-N-H Systems Using 6Li Magic Angle Spinning Nuclear Magnetic Resonance at Ultra-High Field

    SciTech Connect

    Hu, Jian Zhi; Kwak, Ja Hun; Yang, Zhenguo; Osborn, William; Markmaitree, Tippawan; Shaw, Leonard D.

    2008-07-15

    Abstract The significantly enhanced spectral resolution in the 6Li MAS NMR spectra of Li-N-H systems at ultra-high field of 21.1 tesla is exploited, for the first time, to study the detailed electronic and chemical environmental changes associated with mechanical activation of Li-N-H system using high energy balling milling. Complementary to ultra-high field studies, the hydrogen discharge dynamics are investigated using variable temperature in situ 1H MAS NMR at 7.05 tesla field. The significantly enhanced spectral resolution using ultra-high filed of 21.1 tesla was demonstrated along with several major findings related to mechanical activation, including the upfield shift of the resonances in 6Li MAS spectra induced by ball milling, more efficient mechanical activation with ball milling at liquid nitrogen temperature than with ball milling at room temperature, and greatly enhanced hydrogen discharge exhibited by the liquid nitrogen ball milled samples.

  17. Habit formation

    PubMed Central

    Smith, Kyle S.; Graybiel, Ann M.

    2016-01-01

    Habits, both good ones and bad ones, are pervasive in animal behavior. Important frameworks have been developed to understand habits through psychological and neurobiological studies. This work has given us a rich understanding of brain networks that promote habits, and has also helped us to understand what constitutes a habitual behavior as opposed to a behavior that is more flexible and prospective. Mounting evidence from studies using neural recording methods suggests that habit formation is not a simple process. We review this evidence and take the position that habits could be sculpted from multiple dissociable changes in neural activity. These changes occur across multiple brain regions and even within single brain regions. This strategy of classifying components of a habit based on different brain signals provides a potentially useful new way to conceive of disorders that involve overly fixed behaviors as arising from different potential dysfunctions within the brain's habit network. PMID:27069378

  18. Habit formation.

    PubMed

    Smith, Kyle S; Graybiel, Ann M

    2016-03-01

    Habits, both good ones and bad ones, are pervasive in animal behavior. Important frameworks have been developed to understand habits through psychological and neurobiological studies. This work has given us a rich understanding of brain networks that promote habits, and has also helped us to understand what constitutes a habitual behavior as opposed to a behavior that is more flexible and prospective. Mounting evidence from studies using neural recording methods suggests that habit formation is not a simple process. We review this evidence and take the position that habits could be sculpted from multiple dissociable changes in neural activity. These changes occur across multiple brain regions and even within single brain regions. This strategy of classifying components of a habit based on different brain signals provides a potentially useful new way to conceive of disorders that involve overly fixed behaviors as arising from different potential dysfunctions within the brain's habit network.

  19. High-field magnetization of heusler alloys Fe2 XY ( X = Ti, V, Cr, Mn, Fe, Co, Ni; Y = Al, Si)

    NASA Astrophysics Data System (ADS)

    Kourov, N. I.; Marchenkov, V. V.; Korolev, A. V.; Belozerova, K. A.; Weber, H. W.

    2015-10-01

    The magnetization curves of ferromagnetic Heusler alloys Fe2 XY (where X = Ti, V, Cr, Mn, Fe, Co, Ni are transition 3 d elements and Y = Al, Si are the s and p elements of the third period of the Periodic Table) have been measured at T = 4.2 K in the field range H ≤ 70 kOe. It has been shown that the high-field ( H ≥ 20 kOe) magnetization is described within the Stoner model.

  20. Design of a High Field Stress, Velvet Cathode for the Flash X-Ray (FXR) Induction Accelerator

    SciTech Connect

    Houck, T; Brown, C; Fleming, D; Kreitzer, B; Lewis, K; Ong, M; Zentler, J

    2007-06-08

    A new cathode design has been proposed for the Flash X-Ray (FXR) induction linear accelerator with the goal of lowering the beam emittance. The original design uses a conventional Pierce geometry and applies a peak field of 134 kV/cm (no beam) to the velvet emission surface. Voltage/current measurements indicate that the velvet begins emitting near this peak field value and images of the cathode show a very non-uniform distribution of plasma light. The new design has a flat cathode/shroud profile that allows for a peak field stress of 230 kV/cm on the velvet. The emission area is reduced by about a factor of four to generate the same total current due to the greater field stress. The relatively fast acceleration of the beam, approximately 2.5 MeV in 10 cm, reduces space charge forces that tend to hollow the beam for a flat, non-Pierce geometry. The higher field stress achieved with the same rise time is expected to lead to an earlier and more uniform plasma formation over the velvet surface. Simulations and initial testing are presented.

  1. Alignment of bicelles studied with high-field magnetic birefringence and small-angle neutron scattering measurements.

    PubMed

    Liebi, Marianne; van Rhee, Peter G; Christianen, Peter C M; Kohlbrecher, Joachim; Fischer, Peter; Walde, Peter; Windhab, Erich J

    2013-03-12

    Birefringence measurements at high magnetic field strength of up to 33 T were used to detect magnetically induced alignment of bicelles composed of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), cholesterol, and 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-diethylenetriaminepentaacetate (DMPE-DTPA) with complexed lanthanide ions. These birefringence measurements together with a small-angle neutron scattering (SANS) analysis in a magnetic field showed parallel alignment of the bicelles if the lanthanide was thulium (Tm(3+)), and perpendicular alignment with dysprosium (Dy(3+)). With the birefringence measurements, the order parameter S can be determined as a function of the magnetic field strength, if the magnetic alignment reaches saturation. Additional structural information can be obtained if the maximum induced birefringence is considered. The degree of alignment of the studied bicelles increased with decreasing temperature from 40 to 5 °C and showed a new bicellar structure comprising a transient hole formation at intermediate temperatures (20 °C) during heating from 5 to 40 °C.

  2. Arterial spin labeling-fast imaging with steady-state free precession (ASL-FISP): a rapid and quantitative perfusion technique for high-field MRI.

    PubMed

    Gao, Ying; Goodnough, Candida L; Erokwu, Bernadette O; Farr, George W; Darrah, Rebecca; Lu, Lan; Dell, Katherine M; Yu, Xin; Flask, Chris A

    2014-08-01

    Arterial spin labeling (ASL) is a valuable non-contrast perfusion MRI technique with numerous clinical applications. Many previous ASL MRI studies have utilized either echo-planar imaging (EPI) or true fast imaging with steady-state free precession (true FISP) readouts, which are prone to off-resonance artifacts on high-field MRI scanners. We have developed a rapid ASL-FISP MRI acquisition for high-field preclinical MRI scanners providing perfusion-weighted images with little or no artifacts in less than 2 s. In this initial implementation, a flow-sensitive alternating inversion recovery (FAIR) ASL preparation was combined with a rapid, centrically encoded FISP readout. Validation studies on healthy C57/BL6 mice provided consistent estimation of in vivo mouse brain perfusion at 7 and 9.4 T (249 ± 38 and 241 ± 17 mL/min/100 g, respectively). The utility of this method was further demonstrated in the detection of significant perfusion deficits in a C57/BL6 mouse model of ischemic stroke. Reasonable kidney perfusion estimates were also obtained for a healthy C57/BL6 mouse exhibiting differential perfusion in the renal cortex and medulla. Overall, the ASL-FISP technique provides a rapid and quantitative in vivo assessment of tissue perfusion for high-field MRI scanners with minimal image artifacts.

  3. Formation of embryoid bodies using dielectrophoresis

    PubMed Central

    Agarwal, Sneha; Sebastian, Anil; Forrester, Lesley M.; Markx, Gerard H.

    2012-01-01

    Embryoid body (EB) formation forms an important step in embryonic stem cell differentiation invivo. In murine embryonic stem cell (mESC) cultures EB formation is inhibited by the inclusion of leukaemic inhibitory factor (LIF) in the medium. Assembly of mESCs into aggregates by positive dielectrophoresis (DEP) in high field regions between interdigitated oppositely castellated electrodes was found to initiate EB formation. Embryoid body formation in aggregates formed with DEP occurred at a more rapid rate—in fact faster compared to conventional methods—in medium without LIF. However, EB formation also occurred in medium in which LIF was present when the cells were aggregated with DEP. The optimum characteristic size for the electrodes for EB formation with DEP was found to be 75–100 microns; aggregates smaller than this tended to merge, whilst aggregates larger than this tended to split to form multiple EBs. Experiments with ESCs in which green fluorescent protein (GFP) production was targeted to the mesodermal gene brachyury indicated that differentiation within embryoid bodies of this size may preferentially occur along the mesoderm lineage. As hematopoietic lineages during normal development derive from mesoderm, the finding points to a possible application of DEP formed EBs in the production of blood-based products from ESCs. PMID:22655013

  4. Pattern Formation

    NASA Astrophysics Data System (ADS)

    Hoyle, Rebecca

    2006-03-01

    From the stripes of a zebra and the spots on a leopard's back to the ripples on a sandy beach or desert dune, regular patterns arise everywhere in nature. The appearance and evolution of these phenomena has been a focus of recent research activity across several disciplines. This book provides an introduction to the range of mathematical theory and methods used to analyse and explain these often intricate and beautiful patterns. Bringing together several different approaches, from group theoretic methods to envelope equations and theory of patterns in large-aspect ratio-systems, the book also provides insight behind the selection of one pattern over another. Suitable as an upper-undergraduate textbook for mathematics students or as a fascinating, engaging, and fully illustrated resource for readers in physics and biology, Rebecca Hoyle's book, using a non-partisan approach, unifies a range of techniques used by active researchers in this growing field. Accessible description of the mathematical theory behind fascinating pattern formation in areas such as biology, physics and materials science Collects recent research for the first time in an upper level textbook Features a number of exercises - with solutions online - and worked examples

  5. Barrier Formation

    PubMed Central

    Lyaruu, D.M.; Medina, J.F.; Sarvide, S.; Bervoets, T.J.M.; Everts, V.; DenBesten, P.; Smith, C.E.; Bronckers, A.L.J.J.

    2014-01-01

    Enamel fluorosis is an irreversible structural enamel defect following exposure to supraoptimal levels of fluoride during amelogenesis. We hypothesized that fluorosis is associated with excess release of protons during formation of hypermineralized lines in the mineralizing enamel matrix. We tested this concept by analyzing fluorotic enamel defects in wild-type mice and mice deficient in anion exchanger-2a,b (Ae2a,b), a transmembrane protein in maturation ameloblasts that exchanges extracellular Cl− for bicarbonate. Defects were more pronounced in fluorotic Ae2a,b−/− mice than in fluorotic heterozygous or wild-type mice. Phenotypes included a hypermineralized surface, extensive subsurface hypomineralization, and multiple hypermineralized lines in deeper enamel. Mineral content decreased in all fluoride-exposed and Ae2a,b−/− mice and was strongly correlated with Cl−. Exposure of enamel surfaces underlying maturation-stage ameloblasts to pH indicator dyes suggested the presence of diffusion barriers in fluorotic enamel. These results support the concept that fluoride stimulates hypermineralization at the mineralization front. This causes increased release of protons, which ameloblasts respond to by secreting more bicarbonates at the expense of Cl− levels in enamel. The fluoride-induced hypermineralized lines may form barriers that impede diffusion of proteins and mineral ions into the subsurface layers, thereby delaying biomineralization and causing retention of enamel matrix proteins. PMID:24170372

  6. Functional connectivity of the left and right hippocampi: Evidence for functional lateralization along the long-axis using meta-analytic approaches and ultra-high field functional neuroimaging.

    PubMed

    Robinson, Jennifer L; Salibi, Nouha; Deshpande, Gopikrishna

    2016-07-15

    Theories regarding the functional specialization of the hippocampus date back to over a century ago. Two main theories have dominated the field. First, evidence has supported the notion of hemispheric specialization, which appears to be preserved across species. Second, an emergent and mounting set of data has suggested an anterior-posterior neurofunctional gradient. However, no study has examined these theories, and their potential interaction, using objective, robust methodological approaches. Here, we employed an established meta-analytic technique and use ultra-high field, high-resolution functional and structural neuroimaging to examine hippocampal lateralization with consideration for a long-axis differentiation. Data revealed strong support for an evolutionarily preserved hemispheric specialization. Specifically, we found intra- and interhemispheric differences with regard to anterior and posterior functional and structural connectivity, between the right and left hippocampi. For task-independent functional connectivity, we found the right anterior hippocampus to have functional connectivity with a large, distributed network, whereas the left anterior hippocampus demonstrated primarily fronto-limbic connectivity. These patterns were reversed for the posterior segmentations. Not surprisingly, for task-dependent connectivity, we found interhemispheric differences within key ipsilateral structures (i.e., parahippocampal gyrus) for both anterior and posterior segmentations. Furthermore, we identified pivotal neural hubs that share connectivity across behavioral domains, and are supported by structural connectivity (i.e., posterior cingulate cortex). Thus, our data provide evidence for a hemisphere-specific, anterior-posterior specialization of the hippocampal formation. PMID:27132046

  7. Experimental Fusion of Contrast Enhanced High-Field Magnetic Resonance Imaging and High-Resolution Micro-Computed Tomography in Imaging the Mouse Inner Ear

    PubMed Central

    Counter, S. Allen; Damberg, Peter; Aski, Sahar Nikkhou; Nagy, Kálmán; Berglin, Cecilia Engmér; Laurell, Göran

    2015-01-01

    Objective: Imaging cochlear, vestibular, and 8th cranial nerve abnormalities remains a challenge. In this study, the membranous and osseous labyrinths of the wild type mouse inner ear were examined using volumetric data from ultra high-field magnetic resonance imaging (MRI) with gadolinium contrast at 9.4 Tesla and high-resolution micro-computed tomography (µCT) to visualize the scalae and vestibular apparatus, and to establish imaging protocols and parameters for comparative analysis of the normal and mutant mouse inner ear. Methods: For in vivo MRI acquisition, animals were placed in a Milleped coil situated in the isocenter of a horizontal 9.4 T Varian magnet. For µCT examination, cone beam scans were performed ex vivo following MRI using the µCT component of a nanoScan PET/CT in vivo scanner. Results: The fusion of Gd enhanced high field MRI and high-resolution µCT scans revealed the dynamic membranous labyrinth of the perilymphatic fluid filled scala tympani and scala vestibule of the cochlea, and semicircular canals of the vestibular apparatus, within the µCT visualized contours of the contiguous osseous labyrinth. The ex vivo µCT segmentation revealed the surface contours and structural morphology of each cochlea turn and the semicircular canals in 3 planes. Conclusions: The fusion of ultra high-field MRI and high-resolution µCT imaging techniques were complementary, and provided high-resolution dynamic and static visualization of the complex morphological features of the normal mouse inner ear structures, which may offer a valuable approach for the investigation of cochlear and vestibular abnormalities that are associated with birth defects related to genetic inner ear disorders in humans. PMID:26401173

  8. An Ultra-High Field Magnetic Resonance Spectroscopy Study of Post Exercise Lactate, Glutamate and Glutamine Change in the Human Brain.

    PubMed

    Dennis, Andrea; Thomas, Adam G; Rawlings, Nancy B; Near, Jamie; Nichols, Thomas E; Clare, Stuart; Johansen-Berg, Heidi; Stagg, Charlotte J

    2015-01-01

    During strenuous exercise there is a progressive increase in lactate uptake and metabolism into the brain as workload and plasma lactate levels increase. Although it is now widely accepted that the brain can metabolize lactate, few studies have directly measured brain lactate following vigorous exercise. Here, we used ultra-high field magnetic resonance spectroscopy of the brain to obtain static measures of brain lactate, as well as brain glutamate and glutamine after vigorous exercise. The aims of our experiment were to (a) track the changes in brain lactate following recovery from exercise, and (b) to simultaneously measure the signals from brain glutamate and glutamine. The results of our experiment showed that vigorous exercise resulted in a significant increase in brain lactate. Furthermore, both glutamate and glutamine were successfully resolved, and as expected, although contrary to some previous reports, we did not observe any significant change in either amino acid after exercise. We did however observe a negative correlation between glutamate and a measure of fitness. These results support the hypothesis that peripherally derived lactate is taken up by the brain when available. Our data additionally highlight the potential of ultra-high field MRS as a non-invasive way of measuring multiple brain metabolite changes with exercise. PMID:26732236

  9. High-field properties of carbon-doped MgB2 thin films by hybrid physical-chemical vapor deposition using different carbon sources

    NASA Astrophysics Data System (ADS)

    Dai, Wenqing; Ferrando, V.; Pogrebnyakov, A. V.; Wilke, R. H. T.; Chen, Ke; Weng, Xiaojun; Redwing, Joan; Wung Bark, Chung; Eom, Chang-Beom; Zhu, Y.; Voyles, P. M.; Rickel, Dwight; Betts, J. B.; Mielke, C. H.; Gurevich, A.; Larbalestier, D. C.; Li, Qi; Xi, X. X.

    2011-12-01

    We have studied the high-field properties of carbon-doped MgB2 thin films prepared by hybrid physical-chemical vapor deposition (HPCVD). Carbon doping was accomplished by adding carbon-containing gas, such as bis(methylcyclopentadienyl)magnesium and trimethylboron, into the hydrogen carrier gas during the deposition. In both cases, Tc drops slowly and residual resistivity increases considerably with carbon doping. Both the a and c lattice constants increase with carbon content in the films, a behavior different from that of bulk carbon-doped MgB2 samples. The films heavily doped with trimethylboron show very high parallel Hc2 over 70 T at low temperatures and a large temperature derivative -\\rmd H_{ {c2}}^{\\parallel } /\\rmd T near Tc. These behaviors are found to depend on the unique microstructure of the films, which consists of MgB2 layers a few-nanometers thick separated by non-superconducting MgB2C2 layers. This leads to an increase in the parallel Hc2 by the geometrical effect, which is in addition to the significant enhancement of Hc2 due to changes in the scattering rates within and between the two bands present in films doped using both carbon sources. The high Hc2 and high-field Jc(H) values observed in this work are very promising for the application of MgB2 in high magnetic fields.

  10. An Ultra-High Field Magnetic Resonance Spectroscopy Study of Post Exercise Lactate, Glutamate and Glutamine Change in the Human Brain

    PubMed Central

    Dennis, Andrea; Thomas, Adam G.; Rawlings, Nancy B.; Near, Jamie; Nichols, Thomas E.; Clare, Stuart; Johansen-Berg, Heidi; Stagg, Charlotte J.

    2015-01-01

    During strenuous exercise there is a progressive increase in lactate uptake and metabolism into the brain as workload and plasma lactate levels increase. Although it is now widely accepted that the brain can metabolize lactate, few studies have directly measured brain lactate following vigorous exercise. Here, we used ultra-high field magnetic resonance spectroscopy of the brain to obtain static measures of brain lactate, as well as brain glutamate and glutamine after vigorous exercise. The aims of our experiment were to (a) track the changes in brain lactate following recovery from exercise, and (b) to simultaneously measure the signals from brain glutamate and glutamine. The results of our experiment showed that vigorous exercise resulted in a significant increase in brain lactate. Furthermore, both glutamate and glutamine were successfully resolved, and as expected, although contrary to some previous reports, we did not observe any significant change in either amino acid after exercise. We did however observe a negative correlation between glutamate and a measure of fitness. These results support the hypothesis that peripherally derived lactate is taken up by the brain when available. Our data additionally highlight the potential of ultra-high field MRS as a non-invasive way of measuring multiple brain metabolite changes with exercise. PMID:26732236

  11. Molecular deformation and free-solution electrophoresis of DNA-uncharged polymer conjugates at high field strengths: theoretical predictions Part 2: Stretching.

    PubMed

    McCormick, Laurette C; Slater, Gary W

    2007-11-01

    DNA sequencing by electrophoresis can be dramatically sped up by overcoming the need for the sieving medium. Normally it is possible to separate DNA based on size in free solution; however, not end-labeled free-solution electrophoresis (ELFSE) uses a neutral drag-tag molecule to make it possible. In experiments to date, the drag-tag and DNA together form a random coil conformation; while with future generation drag-tags and high fields, deformation of this conformation may occur. In the first paper in this series we investigated the conditions under which the DNA and label become hydrodynamically distinct (or segregated), based on a theoretical approach developed for the electrophoresis of polyampholytes. In this paper we study further deformation wherein either the DNA and/or a polymeric label stretch. We show that deformation may dramatically improve the capabilities of ELFSE, especially when both the DNA and a polymeric drag-tag fully stretch; however, reaching these regimes will require extremely high field intensities, something that only microchip technologies may be able to achieve.

  12. Mode Conversion of High-Field-Side-Launched Fast Waves at the Second Harmonic of Minority Hydrogen in Advanced Tokamak Reactors

    NASA Astrophysics Data System (ADS)

    Sund, R.; Scharer, J.

    2003-12-01

    Under advanced tokamak reactor conditions, the Ion-Bernstein wave (IBW) can be generated by mode conversion of a fast magnetosonic wave incident from the high-field side on the second harmonic resonance of a minority hydrogen component, with near 100% efficiency. IBWs have the recognized capacity to create internal transport barriers through sheared plasma flows resulting from ion absorption. The relatively high frequency (around 200 MHz) minimizes parasitic electron absorption and permits the converted IBW to approach the 5th tritium harmonic. It also facilitates compact antennas and feeds, and efficient fast wave launch. The scheme is applicable to reactors with aspect ratios < 3 such that the conversion and absorption layers are both on the high field side of the magnetic axis. Large machine size and adequate separation of the mode conversion layer from the magnetic axis minimize poloidal field effects in the conversion zone and permit a 1-D full-wave analysis. 2-D ray tracing of the IBW indicates a slightly bean-shaped equilibrium allows access to the tritium resonance.

  13. [Comparative assessment of MR-semiotics of acutest intracerebral hematomas in low- and extra high-field frequency magnetic resonance tomography].

    PubMed

    Skvortsova, V I; Burenchev, D V; Tvorogova, T V; Guseva, O I; Prokhorov, A V; Smirnov, A M; Kupriianov, D A; Pirogov, Iu A

    2009-01-01

    An objective of the study was to compare sensitivity of low- and extra high-field frequency magnetic resonance (MR) tomography of acutest intracerebral hematomas (ICH) and to assess differences between symptoms in obtained images. A study was conducted using experimental ICH in rats (n=6). Hematomas were formed by two injections of autologic blood into the brain. MR-devices "Bio Spec 70/30" with magnetic field strength of 7 T and "Ellipse-150" with magnetic field strength of 0,15 T were used in the study. MR-tomography was carried out 3-5 h after the injections. Both MR-devices revealed the presence of pathological lesion in all animals. Extra highfield frequency MR-tomography showed the specific signs of ICH caused by the paramagnetic effect of deoxyhemoglobin in T2 and T2*-weighted images (WI) and low frequency MR-tomography - in T2*-WI only. The comparable sensitivity of low- and extra high-field frequency MR-devices in acutest ICH was established.

  14. Superferric microundulator with high field

    NASA Astrophysics Data System (ADS)

    Papadichev, V. A.; Vysotsky, V. S.; Tsikhon, V. N.; Eremichev, V. T.

    1993-07-01

    A model of a plane superferric undulator with a period of 8 mm was made and tested. Its length is 100 mm, its width is 50 mm, and 4 and 2.5 mm air gaps between upper and lower poles were used for magnetic measurements. The gap can be changed by inserting spacers of the necessary thickness. The magnetic structure is made of magnetically soft low carbon iron (Armco). The slots for winding were machine cut. The windings are made of 40 turns of Nb 3Sn superconductor or 10 turns of NbTi for the 4 and 2.5 mm gaps, respectively. The maximum current in the first series of experiments was 70 A and in the second series it was 450 A. Poles of three types were tried. The maximum magnetic field amplitude of 7.7 kG was measured with the poles in the form of a trapezoid. This field corresponds to an undulator deflection parameter K = 0.57. Results of magnetic measurements are presented.

  15. The high-field magnet endstation for X-ray magnetic dichroism experiments at ESRF soft X-ray beamline ID32.

    PubMed

    Kummer, K; Fondacaro, A; Jimenez, E; Velez-Fort, E; Amorese, A; Aspbury, M; Yakhou-Harris, F; van der Linden, P; Brookes, N B

    2016-03-01

    A new high-field magnet endstation for X-ray magnetic dichroism experiments has been installed and commissioned at the ESRF soft X-ray beamline ID32. The magnet consists of two split-pairs of superconducting coils which can generate up to 9 T along the beam and up to 4 T orthogonal to the beam. It is connected to a cluster of ultra-high-vacuum chambers that offer a comprehensive set of surface preparation and characterization techniques. The endstation and the beam properties have been designed to provide optimum experimental conditions for X-ray magnetic linear and circular dichroism experiments in the soft X-ray range between 400 and 1600 eV photon energy. User operation started in November 2014. PMID:26917134

  16. Generation of lipid peroxidation products in culinary oils and fats during episodes of thermal stressing: a high field 1H NMR study.

    PubMed

    Claxson, A W; Hawkes, G E; Richardson, D P; Naughton, D P; Haywood, R M; Chander, C L; Atherton, M; Lynch, E J; Grootveld, M C

    1994-11-21

    The oxidative deterioration of glycerol-bound polyunsaturated fatty acids (PUFAs) in culinary oils and fats during episodes of heating associated with normal usage (30-90 min at 180 degrees C) has been monitored by high field 1H NMR spectroscopy. Thermal stressing of PUFA-rich culinary oils generated high levels of n-alkanals, trans-2-alkenals, alka-2,4-dienals and 4-hydroxy-trans-2-alkenals via decomposition of their conjugated hydroperoxydiene precursors, whereas only low concentrations of selected aldehydes were produced in oils with a low PUFA content, lard and dripping when subjected to the above heating episodes. Samples of repeatedly used, PUFA-rich culinary oils obtained from restaurants also contained high levels of each class of aldehyde. The dietary, physiological and toxicological ramifications of the results obtained are discussed.

  17. Novel mono-static arrangement of the ASDEX Upgrade high field side reflectometers compatible with electron cyclotron resonance heating stray radiation.

    PubMed

    Silva, A; Varela, P; Meneses, L; Manso, M

    2012-10-01

    The ASDEX Upgrade frequency modulated continuous wave broadband reflectometer system uses a mono-static antenna configuration with in-vessel hog-horns and 3 dB directional couplers. The operation of the new electron cyclotron resonance heating (ECRH) launcher and the start of collective Thomson scattering experiments caused several events where the fragile dummy loads inside the high field side directional couplers were damaged, due to excessive power resulting from the ECRH stray fields. In this paper, we present a non-conventional application of the existing three-port directional coupler that hardens the system to the ECRH stray fields and at the same time generates the necessary reference signal. Electromagnetic simulations and laboratory tests were performed to validate the proposed solution and are compared with the in-vessel calibration tests.

  18. Reactive spark plasma sintering of MgB2 in nitrogen atmosphere for the enhancement of the high-field critical current density

    NASA Astrophysics Data System (ADS)

    Badica, P.; Burdusel, M.; Popa, S.; Pasuk, I.; Ivan, I.; Borodianska, H.; Vasylkiv, O.; Kuncser, A.; Ionescu, A. M.; Miu, L.; Aldica, G.

    2016-10-01

    High density bulks (97%-99%) of MgB2 were prepared by spark plasma sintering (SPS) in nitrogen (N2) atmosphere for different heating rates (10, 20 and 100 °C min-1) and compared with reference samples processed in vacuum and Ar. N2 reacts with MgB2 and forms MgB9N along the MgB2 grain boundaries. The high-field critical current density is enhanced for the sample processed in N2 with a heating rate of 100 °C min-1. At 2-35 K, this sample shows the strongest contribution of the grain boundary pinning (GBP). All samples are in the point pinning (PP) limit and by increasing temperature the GBP contribution decreases.

  19. An Analytical Technique to Elucidate Field Impurities From Manufacturing Uncertainties of an Double Pancake Type HTS Insert for High Field LTS/HTS NMR Magnets

    PubMed Central

    Hahn, Seung-yong; Ahn, Min Cheol; Bobrov, Emanuel Saul; Bascuñán, Juan; Iwasa, Yukikazu

    2010-01-01

    This paper addresses adverse effects of dimensional uncertainties of an HTS insert assembled with double-pancake coils on spatial field homogeneity. Each DP coil was wound with Bi2223 tapes having dimensional tolerances larger than one order of magnitude of those accepted for LTS wires used in conventional NMR magnets. The paper presents: 1) dimensional variations measured in two LTS/HTS NMR magnets, 350 MHz (LH350) and 700 MHz (LH700), both built and operated at the Francis Bitter Magnet Laboratory; and 2) an analytical technique and its application to elucidate the field impurities measured with the two LTS/HTS magnets. Field impurities computed with the analytical model and those measured with the two LTS/HTS magnets agree quite well, demonstrating that this analytical technique is applicable to design a DP-assembled HTS insert with an improved field homogeneity for a high-field LTS/HTS NMR magnet. PMID:20407595

  20. An Analytical Technique to Elucidate Field Impurities From Manufacturing Uncertainties of an Double Pancake Type HTS Insert for High Field LTS/HTS NMR Magnets.

    PubMed

    Hahn, Seung-Yong; Ahn, Min Cheol; Bobrov, Emanuel Saul; Bascuñán, Juan; Iwasa, Yukikazu

    2009-06-01

    This paper addresses adverse effects of dimensional uncertainties of an HTS insert assembled with double-pancake coils on spatial field homogeneity. Each DP coil was wound with Bi2223 tapes having dimensional tolerances larger than one order of magnitude of those accepted for LTS wires used in conventional NMR magnets. The paper presents: 1) dimensional variations measured in two LTS/HTS NMR magnets, 350 MHz (LH350) and 700 MHz (LH700), both built and operated at the Francis Bitter Magnet Laboratory; and 2) an analytical technique and its application to elucidate the field impurities measured with the two LTS/HTS magnets. Field impurities computed with the analytical model and those measured with the two LTS/HTS magnets agree quite well, demonstrating that this analytical technique is applicable to design a DP-assembled HTS insert with an improved field homogeneity for a high-field LTS/HTS NMR magnet.

  1. A strip-shield improves the efficiency of a solenoid coil in probes for high field solid-state NMR of lossy biological samples

    PubMed Central

    Wu, Chin H.; Grant, Christopher V.; Cook, Gabriel A.; Park, Sang Ho; Opella, Stanley J.

    2009-01-01

    A strip-shield inserted between a high inductance double-tuned solenoid coil and the glass tube containing the sample improves the efficiency of probes used for high-field solid-state NMR experiments on lossy aqueous samples of proteins and other biopolymers. A strip-shield is a coil liner consisting of thin copper strips layered on a PTFE (polytetrafluoroethylene) insulator. With lossy samples, the shift in tuning frequency is smaller, the reduction in Q, and RF-induced heating are all significantly reduced when the strip-shield is present. The performance of 800 MHz 1H/15N and 1H/13C double-resonance probes is demonstrated on aqueous samples of membrane proteins in phospholipid bilayers. PMID:19559634

  2. Laserspray and matrix-assisted ionization inlet coupled to high-field FT-ICR mass spectrometry for peptide and protein analysis.

    PubMed

    Nyadong, Leonard; Inutan, Ellen D; Wang, Xu; Hendrickson, Christopher L; Trimpin, Sarah; Marshall, Alan G

    2013-03-01

    We present the first coupling of laser spray ionization inlet (LSII) and matrix assisted ionization inlet (MAII) to high-field Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) for generation of electrospray-like ions to take advantage of increased sensitivity, mass range, and mass resolving power afforded by multiple charging. We apply the technique to top-down protein analysis and characterization of metalloproteins. We also present a novel method for generation of multiply-charged copper-peptide complexes with varying degrees of copper adduction by LSII. We show an application of the generated copper-peptide complexes for protein charge state and molecular weight determination, particularly useful for an instrument such as a linear ion trap mass analyzer. PMID:23381687

  3. Laserspray and Matrix-Assisted Ionization Inlet Coupled to High-Field FT-ICR Mass Spectrometry for Peptide and Protein Analysis

    NASA Astrophysics Data System (ADS)

    Nyadong, Leonard; Inutan, Ellen D.; Wang, Xu; Hendrickson, Christopher L.; Trimpin, Sarah; Marshall, Alan G.

    2013-03-01

    We present the first coupling of laser spray ionization inlet (LSII) and matrix assisted ionization inlet (MAII) to high-field Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) for generation of electrospray-like ions to take advantage of increased sensitivity, mass range, and mass resolving power afforded by multiple charging. We apply the technique to top-down protein analysis and characterization of metalloproteins. We also present a novel method for generation of multiply-charged copper-peptide complexes with varying degrees of copper adduction by LSII. We show an application of the generated copper-peptide complexes for protein charge state and molecular weight determination, particularly useful for an instrument such as a linear ion trap mass analyzer. [Figure not available: see fulltext.

  4. High-field (11.75T) multimodal MR imaging of exercising hindlimb mouse muscles using a non-invasive combined stimulation and force measurement device.

    PubMed

    Gondin, Julien; Vilmen, Christophe; Cozzone, Patrick J; Bendahan, David; Duhamel, Guillaume

    2014-08-01

    We have designed and constructed an experimental set-up allowing electrical stimulation of hindlimb mouse muscles and the corresponding force measurements at high-field (11.75T). We performed high-resolution multimodal MRI (including T2 -weighted imaging, angiography and diffusion) and analysed the corresponding MRI changes in response to a stimulation protocol. Mice were tested twice over a 1-week period to investigate the reliability of mechanical measurements and T2 changes associated with the stimulation protocol. Additionally, angiographic images were obtained before and immediately after the stimulation protocol. Finally, multislice diffusion imaging was performed before, during and immediately after the stimulation session. Apparent diffusion coefficient (ADC) maps were calculated on the basis of diffusion weighted images (DWI). Both force production and T2 values were highly reproducible as illustrated by the low coefficient of variation (<8%) and high intraclass correlation coefficient (≥0.75) values. Maximum intensity projection angiographic images clearly showed a strong vascular effect resulting from the stimulation protocol. Although a motion sensitive imaging sequence was used (echo planar imaging) and in spite of the strong muscle contractions, motion artifacts were minimal for DWI recorded under exercising conditions, thereby underlining the robustness of the measurements. Mean ADC values increased under exercising conditions and were higher during the recovery period as compared with the corresponding control values. The proposed experimental approach demonstrates accurate high-field multimodal MRI muscle investigations at a preclinical level which is of interest for monitoring the severity and/or the progression of neuromuscular diseases but also for assessing the efficacy of potential therapeutic interventions.

  5. Common File Formats.

    PubMed

    Mills, Lauren

    2014-03-21

    An overview of the many file formats commonly used in bioinformatics and genome sequence analysis is presented, including various data file formats, alignment file formats, and annotation file formats. Example workflows illustrate how some of the different file types are typically used.

  6. Formate Formation and Formate Conversion in Biological Fuels Production

    PubMed Central

    Crable, Bryan R.; Plugge, Caroline M.; McInerney, Michael J.; Stams, Alfons J. M.

    2011-01-01

    Biomethanation is a mature technology for fuel production. Fourth generation biofuels research will focus on sequestering CO2 and providing carbon-neutral or carbon-negative strategies to cope with dwindling fossil fuel supplies and environmental impact. Formate is an important intermediate in the methanogenic breakdown of complex organic material and serves as an important precursor for biological fuels production in the form of methane, hydrogen, and potentially methanol. Formate is produced by either CoA-dependent cleavage of pyruvate or enzymatic reduction of CO2 in an NADH- or ferredoxin-dependent manner. Formate is consumed through oxidation to CO2 and H2 or can be further reduced via the Wood-Ljungdahl pathway for carbon fixation or industrially for the production of methanol. Here, we review the enzymes involved in the interconversion of formate and discuss potential applications for biofuels production. PMID:21687599

  7. Regional in vivo transit time measurements of aortic pulse wave velocity in mice with high-field CMR at 17.6 Tesla

    PubMed Central

    2010-01-01

    Background Transgenic mouse models are increasingly used to study the pathophysiology of human cardiovascular diseases. The aortic pulse wave velocity (PWV) is an indirect measure for vascular stiffness and a marker for cardiovascular risk. Results This study presents a cardiovascular magnetic resonance (CMR) transit time (TT) method that allows the determination of the PWV in the descending murine aorta by analyzing blood flow waveforms. Systolic flow pulses were recorded with a temporal resolution of 1 ms applying phase velocity encoding. In a first step, the CMR method was validated by pressure waveform measurements on a pulsatile elastic vessel phantom. In a second step, the CMR method was applied to measure PWVs in a group of five eight-month-old apolipoprotein E deficient (ApoE(-/-)) mice and an age matched group of four C57Bl/6J mice. The ApoE(-/-) group had a higher mean PWV (PWV = 3.0 ± 0.6 m/s) than the C57Bl/6J group (PWV = 2.4 ± 0.4 m/s). The difference was statistically significant (p = 0.014). Conclusions The findings of this study demonstrate that high field CMR is applicable to non-invasively determine and distinguish PWVs in the arterial system of healthy and diseased groups of mice. PMID:21134260

  8. Investigation of the Structure and Active Sites of TiO2 Nanorod Supported VOx Catalysts by High-Field and Fast-Spinning 51V MAS NMR

    SciTech Connect

    Hu, Jian Z.; Xu, Suochang; Li, Weizhen; Hu, Mary Y.; Deng, Xuchu; Dixon, David A.; Vasiliu, Monica; Craciun, Raluca; Wang, Yong; Bao, Xinhe; Peden, Charles HF

    2015-07-02

    Supported VOx/TiO2-Rod catalysts were studied by 51V MAS NMR at high field using a sample spinning rate of 55 kHz. The superior spectral resolution allows for the observation of at least five vanadate species. The assignment of these vanadate species was carried out by quantum mechanical calculations of 51V NMR chemical shifts of model V-surface structures. Methanol oxidative dehydrogenation (ODH) was used to establish the correlation between the reaction rate and the various surface V-sites. It is found that monomeric V-species dominated the catalyst at low vanadium loadings with two peaks observed at about -502 and -529 ppm. V-dimers with two bridged oxygen appeare at about -555 ppm. Vanadate dimers and polyvanadates connected by one bridged oxygen atom between two adjacent V atoms resonate at about -630 ppm. A positive correlation is found between the V-dimers related to the -555 ppm peak and the ODH rate while a better correlation is obtained by including monomeric contributions. This result indicates that surface V-dimers related to the -555 ppm peak are the major active sites for ODH reaction despite mono-V species are more catalytic active but their relative ratios are decreased dramatically at high V-loadings. Furthermore, a portion of the V-species is found invisible. In particular, the level of such invisibility increases with decreased level of V-loading, suggesting the existence of paramagnetic V-species at the surface.

  9. Measurements of ion cyclotron parametric decay of lower hybrid waves at the high-field side of Alcator C-Mod

    NASA Astrophysics Data System (ADS)

    Baek, S. G.; Parker, R. R.; Shiraiwa, S.; Wallace, G. M.; Bonoli, P. T.; Brunner, D.; Faust, I. C.; Hubbard, A. E.; LaBombard, B.; Porkolab, M.

    2013-05-01

    Ion cyclotron parametric decay instability (PDI) of lower hybrid (LH) waves is surveyed using edge Langmuir probes on the Alcator C-Mod tokamak. The measurement is carried out simultaneously at the high-field side (HFS) and low-field side (LFS) mid-plane of the tokamak, as well as in the outer divertor region. Different LH spectra are observed depending on the location of the probes and magnetic configuration in L-mode plasmas, with \\overrightarrow{B}\\times\\bigtriangledown B drift direction downward. In lower single null (LSN) plasmas, strong ion cyclotron PDI occurring at the HFS is observed for the first time. This instability is characterized by a frequency separation in sidebands corresponding to the ion cyclotron frequency (ωci) near the HFS scrape-off layer and develops with threshold-like behavior as density increases. In inner wall limited (IWL) plasmas, this HFS instability shows a higher density threshold compared with that in LSN plasmas. The pump width becomes broadened even in the absence of the sidebands. In upper single null plasmas with similar plasma parameters, ion cyclotron PDI sidebands have a frequency separation corresponding to ωci near the LFS and are weaker than those observed in the LSN and IWL plasmas. Correlation between the onset of ion cyclotron PDI and the observed loss of lower hybrid current drive efficiency (Wallace et al 2012 Phys. Plasmas 19 062505) is discussed.

  10. Influence of paramagnetic melanin on the MRI contrast in melanoma: a combined high-field (11.7 T) MRI and EPR study.

    PubMed

    Godechal, Q; Mignion, L; Karroum, O; Magat, J; Danhier, P; Morandini, R; Ghanem, G E; Leveque, P; Gallez, B

    2014-01-01

    Melanoma is the most dangerous form of skin cancer and its incidence is rising each year. Because the current methods of diagnosis based on the visual aspect of the tumor show limitations, several new techniques are emerging to help in this diagnosis, amongst which are magnetic resonance imaging (MRI) and electron paramagnetic resonance (EPR). The origin of the typical contrast pattern observable in melanoma in T1 - and T2 -weighted images remains to be elucidated and is a source of controversy. In addition, melanin could create sufficient magnetic inhomogeneities to allow its visualization on T2 *-weighted images using high-field MRI. In order to elucidate the possible role of melanin in the MRI contrast of melanoma, the present study was designed to correlate the paramagnetic content in melanin pigment to the contrast on T1 -, T2 - and T2 *-weighted images. MR images were obtained in vivo at 11.7 T using four types of experimental tumors with different pigmentations (B16, HBL, LND1 melanomas and KHT sarcomas). The paramagnetic content in melanin pigment was measured by EPR. No significant correlation was observed between the content in melanin and the relaxation times T1 , T2 and T2 *, emphasizing that the presence of pigment alone has negligible effect on the MRI contrast.

  11. Development of high field SQUID magnetometer for magnetization studies up to 7 T and temperatures in the range from 4.2 to 300 K

    SciTech Connect

    Nagendran, R.; Thirumurugan, N.; Chinnasamy, N.; Janawadkar, M. P.; Sundar, C. S.

    2011-01-15

    We present the design, fabrication, integration, testing, and calibration of a high field superconducting quantum interference device (SQUID) magnetometer. The system is based on dc SQUID sensor with flux locked loop readout electronics. The design is modular and all the subsystems have been fabricated in the form of separate modules in order to simplify the assembly and for ease of maintenance. A novel feature of the system is that the current induced in the pickup loop is distributed as inputs to two different SQUID sensors with different strengths of coupling in order to improve the dynamic range of the system. The SQUID magnetometer has been calibrated with yttrium iron garnet (YIG) sphere as a standard reference material. The calibration factor was determined by fitting the measured flux profile of the YIG sphere to that expected for a point dipole. Gd{sub 2}O{sub 3} was also used as another reference material for the calibration and the effective magnetic moment of the Gd{sup 3+} could be evaluated from the temperature dependent magnetization measurements. The sensitivity of the system has been estimated to be about 10{sup -7} emu at low magnetic fields and about 10{sup -5} emu at high magnetic fields {approx}7 T.

  12. Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

    PubMed Central

    Irazabal, Maria V.; Mishra, Prasanna K.; Torres, Vicente E.; Macura, Slobodan I.

    2015-01-01

    Several in vivo pre-clinical studies in Polycystic Kidney Disease (PKD) utilize orthologous rodent models to identify and study the genetic and molecular mechanisms responsible for the disease, and are very convenient for rapid drug screening and testing of promising therapies. A limiting factor in these studies is often the lack of efficient non-invasive methods for sequentially analyzing the anatomical and functional changes in the kidney. Magnetic resonance imaging (MRI) is the current gold standard imaging technique to follow autosomal dominant polycystic kidney disease (ADPKD) patients, providing excellent soft tissue contrast and anatomic detail and allowing Total Kidney Volume (TKV) measurements.A major advantage of MRI in rodent models of PKD is the possibility for in vivo imaging allowing for longitudinal studies that use the same animal and therefore reducing the total number of animals required. In this manuscript, we will focus on using Ultra-high field (UHF) MRI to non-invasively acquire in vivo images of rodent models for PKD. The main goal of this work is to introduce the use of MRI as a tool for in vivo phenotypical characterization and drug monitoring in rodent models for PKD. PMID:26132821

  13. An improved oxygen diffusion model to explain the effect of low-temperature baking on high field losses in niobium superconducting cavities

    SciTech Connect

    Ciovati, Gianluigi

    2006-07-01

    Radio-frequency (RF) superconducting cavities made of high purity niobium are widely used to accelerate charged particle beams in particle accelerators. The major limitation to achieve RF field values approaching the theoretical limit for niobium is represented by ''anomalous'' losses which degrade the quality factor of the cavities starting at peak surface magnetic fields of about 100 mT, in absence of field emission. These high field losses are often referred to as ''Q-drop''. It has been observed that the Q-drop is drastically reduced by baking the cavities at 120 C for about 48 h under ultrahigh vacuum. An improved oxygen diffusion model for the niobium-oxide system is proposed to explain the benefit of the low-temperature baking on the Q-drop in niobium superconducting rf cavities. The model shows that baking at 120 C for 48 h allows oxygen to diffuse away from the surface, and therefore increasing the lower critical field towards the value for pure niobium.

  14. Limits of NbTi and Nb3Sn, and Development of W&R Bi-2212 HighField Accelerator Magnets

    SciTech Connect

    Godeke, A.; Cheng, D.; Dietderich, D.R.; Ferracin, P.; Prestemon,S.O.; Sa bbi, G.; Scanlan, R.M.

    2006-09-01

    NbTi accelerator dipoles are limited to magneticfields (H)of about 10 T, due to an intrinsic upper critical field (Hc2) limitationof 14 T. To surpass this restriction, prototype Nb3Sn magnets are beingdeveloped which have reached 16 T. We show that Nb3Sn dipole technologyis practically limited to 17 to 18 T due to insufficient high fieldpinning, and intrinsically to 20 to 22 T due to Hc2 limitations.Therefore, to obtain magnetic fields approaching 20 T and higher, amaterial is required with a higher Hc2 and sufficient high field pinningcapacity. A realistic candidate for this purpose is Bi-2212, which isavailable in roundwires and sufficient lengths for the fabrication ofcoils based on Rutherford-type cables. We initiated a program to developthe required technology to construct accelerator magnets from'windand-react' (W&R) Bi-2212 coils. We outline the complicationsthat arise through the use of Bi-2212, describe the development paths toaddress these issues, and conclude with the design of W&R Bi-2212sub-scale magnets.

  15. Limits of NbTi and Nb3Sn, and Development of W&R Bi-2212 HighField Accelerator Magnets

    SciTech Connect

    Godeke, A.; Cheng, D.; Dietderich, D.R.; Ferracin, P.; Prestemon,S.O.; Sabbi, G.; Scanlan, R.M.

    2006-12-01

    NbTi accelerator dipoles are limited to magnetic fields (H)of about 10 T, due to an intrinsic upper critical field(Hc2) limitationof 14 T. To surpass this restriction, prototype Nb3Sn magnets are beingdeveloped which have reached 16 T. We show that Nb3Sn dipole technologyis practically limited to 17 to 18 T due to insufficient high fieldpinning, and intrinsically to 20 to 22 T due to Hc2 limitations.Therefore, to obtain magnetic fields approaching 20 T and higher, amaterial is required with a higher Hc2 and sufficient high field pinningcapacity. A realistic candidate for this purpose is Bi-2212, which isavailable in roundwires and sufficient lengths for the fabrication ofcoils based on Rutherford-type cables. We initiated a program to developthe required technology to construct accelerator magnets from'windand-react' (W&R) Bi-2212 coils. We outline the complicationsthat arise through the use of Bi-2212, describe the development paths toaddress these issues, and conclude with the design of W&R Bi-2212sub-scale magnets.

  16. Trace level impurity method development with high-field asymmetric waveform ion mobility spectrometry: systematic study of factors affecting the performance.

    PubMed

    Champarnaud, Elodie; Laures, Alice M-F; Borman, Phil J; Chatfield, Marion J; Kapron, James T; Harrison, Mark; Wolff, Jean-Claude

    2009-01-01

    For the determination of trace level impurities, analytical chemists are confronted with complex mixtures and difficult separations. New technologies such as high-field asymmetric waveform ion mobility spectrometry (FAIMS) have been developed to make their work easier; however, efficient method development and troubleshooting can be quite challenging if little prior knowledge of the factors or their settings is available. We present the results of an investigation performed in order to obtain a better understanding of the FAIMS technology. The influence of eight factors (polarity of dispersion voltage, outer bias voltage, total gas flow rate, composition of the carrier gas (e.g. %He), outer electrode temperature, ratio between the temperatures of the inner and outer electrodes, flow rate and composition of the make-up mobile phase) was assessed. Five types of responses were monitored: value of the compensation voltage (CV), intensity, width and asymmetry of the compensation voltage peak, and resolution between two peaks. Three types of studies were performed using different test mixtures and various ionisation modes to assess whether the same conclusions could be drawn across these conditions for a number of different types of compounds. To extract the maximum information from as few experiments as possible, a Design of Experiment (DoE) approach was used. The results presented in this work provide detailed information on the factors affecting FAIMS separations and therefore should enable the user to troubleshoot more effectively and to develop efficient methods. PMID:19065601

  17. Cotton-mouton effects, magnetic hyperpolarizabilities, and magnetic anisotropies of the methyl halides. Comparison with molecular Zeeman and high-field NMR spectroscopic results

    SciTech Connect

    Coonan, M.H.; Ritchie, G.L.D. )

    1991-02-07

    Measurements of the vapor-phase Cotton-Mouton effects of methyl fluoride, methyl bromide, and methyl iodide are reported. Analysis of the results, in conjunction with those of an earlier study of methane and methyl chloride, shows that in the series CH{sub 3}X (X = H, F, Cl, Br, I) the magnetic hyperpolarizabiity anisotropy, which is related to the quadratic response of the molecular polarizability to a magnetic field, is positive in sign and roughly proportional in magnitude to the mean polarizability. The magnetic anisotropies (10{sup 29}{Delta}{sub {chi}}/J T{sup {minus}2}) found for methyl chloride,methyl bromide, and methyl iodide (CH{sub 3}Cl, {minus}15.0 {plus minus} 1.3; CH{sub 3}Br, -15.1 {plus minus} 0.8; CH{sub 3}I, {minus}18.0 {plus minus} 1.5) are compared with values obtained by the molecular Zeeman and high-field {sup 2}H NMR spectroscopic methods.

  18. A high-field magnetic resonance imaging spectrometer using an oven-controlled crystal oscillator as the local oscillator of its radio frequency transceiver.

    PubMed

    Liang, Xiao; Tang, Xin; Tang, Weinan; Gao, Jia-Hong

    2014-09-01

    A home-made high-field magnetic resonance imaging (MRI) spectrometer with multiple receiving channels is described. The radio frequency (RF) transceiver of the spectrometer consists of digital intermediate frequency (IF) circuits and corresponding mixing circuits. A direct digital synthesis device is employed to generate the IF pulse; the IF signal from a down-conversion circuit is sampled and followed by digital quadrature detection. Both the IF generation and the IF sampling use a 50 MHz clock. An oven-controlled crystal oscillator, which has outstanding spectral purity and a compact circuit, is used as the local oscillator of the RF transceiver. A digital signal processor works as the pulse programmer of the spectrometer, as a result, 32 control lines can be generated simultaneously while an event is triggered. Field programmable gate array devices are utilized as the auxiliary controllers of the IF generation, IF receiving, and gradient control. High performance, including 1 μs time resolution of the soft pulse, 1 MHz receiving bandwidth, and 1 μs time resolution of the gradient waveform, is achieved. High-quality images on a 1.5 T MRI system using the spectrometer are obtained.

  19. High-field asymmetric waveform ion mobility spectrometry for determining the location of in-source collision-induced dissociation in electrospray ionization mass spectrometry.

    PubMed

    Xia, Yuan-Qing; Jemal, Mohammed

    2009-09-15

    The understanding and control of the in-source collision-induced dissociation (CID) of analytes is important for the accurate LC-MS/MS quantitation of drugs and metabolites in biological samples. Accordingly, it was of interest to us to establish whether such in-source CID takes place after and/or before the orifice of an electrospray ionization (ESI) mass spectrometer. A high-field asymmetric waveform ion mobility spectrometry (FAIMS) system that is physically located between the sprayer and the orifice of a mass spectrometer can serve as an ion filter to control ions entering the orifice of the mass spectrometer. In such a configuration, FAIMS could conceivably be used to determine if the in-source CID of an analyte occurs after and/or before the mass spectrometer orifice. We demonstrated this capability of FAIMS using ifetroban acylglucuronide metabolite as a model compound. Under the conditions used, the results showed that the in-source CID conversion of the acylglucuronide metabolite to its parent drug ifetroban occurred almost entirely after the orifice of the mass spectrometer, with the conversion upstream of the orifice accounting for only 5.6% of the conversion. Under the circumstance, the term "post-orifice CID" rather than "in-source CID" may be more appropriate in describing such a dissociation occurring in the front end of a mass spectrometer.

  20. Development of high field SQUID magnetometer for magnetization studies up to 7 T and temperatures in the range from 4.2 to 300 K.

    PubMed

    Nagendran, R; Thirumurugan, N; Chinnasamy, N; Janawadkar, M P; Sundar, C S

    2011-01-01

    We present the design, fabrication, integration, testing, and calibration of a high field superconducting quantum interference device (SQUID) magnetometer. The system is based on dc SQUID sensor with flux locked loop readout electronics. The design is modular and all the subsystems have been fabricated in the form of separate modules in order to simplify the assembly and for ease of maintenance. A novel feature of the system is that the current induced in the pickup loop is distributed as inputs to two different SQUID sensors with different strengths of coupling in order to improve the dynamic range of the system. The SQUID magnetometer has been calibrated with yttrium iron garnet (YIG) sphere as a standard reference material. The calibration factor was determined by fitting the measured flux profile of the YIG sphere to that expected for a point dipole. Gd(2)O(3) was also used as another reference material for the calibration and the effective magnetic moment of the Gd(3+) could be evaluated from the temperature dependent magnetization measurements. The sensitivity of the system has been estimated to be about 10(-7) emu at low magnetic fields and about 10(-5) emu at high magnetic fields ∼7 T.

  1. High critical current density and low anisotropy in textured Sr1−xKxFe2As2 tapes for high field applications

    PubMed Central

    Gao, Zhaoshun; Ma, Yanwei; Yao, Chao; Zhang, Xianping; Wang, Chunlei; Wang, Dongliang; Awaji, Satoshi; Watanabe, Kazuo

    2012-01-01

    From the application point of view, large critical current densities Jc (H) for superconducting wires are required, preferably for magnetic fields higher than 5 T. Here we show that strong c-axis textured Sr1−xKxFe2As2 tapes with nearly isotropic transport Jc were fabricated by an ex-situ powder-in-tube (PIT) process. At 4.2 K, the Jc values show extremely weak magnetic field dependence and reach high values of 1.7×104 A/cm2 at 10 T and 1.4×104 A/cm2 at 14 T, respectively, these values are by far the highest ever reported for iron based wires and approach the Jc level desired for practical applications. Transmission electron microscopy investigations revealed that amorphous oxide layers at grain boundaries were significantly reduced by Sn addition which resulted in greatly improved intergranular connectivity. Our results demonstrated the strong potential of using iron based superconductors for high field applications. PMID:23256034

  2. The Format Dilemma.

    ERIC Educational Resources Information Center

    Oder, Norman

    2002-01-01

    Reports results of a survey of public libraries that investigated trends in audiovisual materials. Highlights include format issues; audiobooks; media budgets for various formats; video collections; DVDs; circulation; collection sizes; music CDs; and future possibilities. (LRW)

  3. Star Formation in Galaxies

    NASA Technical Reports Server (NTRS)

    1987-01-01

    Topics addressed include: star formation; galactic infrared emission; molecular clouds; OB star luminosity; dust grains; IRAS observations; galactic disks; stellar formation in Magellanic clouds; irregular galaxies; spiral galaxies; starbursts; morphology of galactic centers; and far-infrared observations.

  4. Simple Ontology Format (SOFT)

    SciTech Connect

    Sorokine, Alexandre

    2011-10-01

    Simple Ontology Format (SOFT) library and file format specification provides a set of simple tools for developing and maintaining ontologies. The library, implemented as a perl module, supports parsing and verification of the files in SOFt format, operations with ontologies (adding, removing, or filtering of entities), and converting of ontologies into other formats. SOFT allows users to quickly create ontologies using only a basic text editor, verify it, and portray it in a graph layout system using customized styles.

  5. Record Formatting: MARC AMC.

    ERIC Educational Resources Information Center

    Weber, Lisa B.

    1990-01-01

    Discusses how archivists use the MARC AMC (Archival and Manuscripts Control) format for descriptive information about archival materials. Modifications that MARC AMC introduced to the standard MARC bibliographic formats are explained, and examples of a record in AMC formats on different bibliographic utilities are given. (24 references) (LRW)

  6. Evaluation of Magnetic Resonance Imaging-Compatible Needles and Interactive Sequences for Musculoskeletal Interventions Using an Open High-Field Magnetic Resonance Imaging Scanner

    SciTech Connect

    Wonneberger, Uta; Schnackenburg, Bernhard; Streitparth, Florian Walter, Thula Rump, Jens Teichgraeber, Ulf K. M.

    2010-04-15

    In this article, we study in vitro evaluation of needle artefacts and image quality for musculoskeletal laser-interventions in an open high-field magnetic resonance imaging (MRI) scanner at 1.0T with vertical field orientation. Five commercially available MRI-compatible puncture needles were assessed based on artefact characteristics in a CuSO4 phantom (0.1%) and in human cadaveric lumbar spines. First, six different interventional sequences were evaluated with varying needle orientation to the main magnetic field B0 (0{sup o} to 90{sup o}) in a sequence test. Artefact width, needle-tip error, and contrast-to-noise ratio (CNR) were calculated. Second, a gradient-echo sequence used for thermometric monitoring was assessed and in varying echo times, artefact width, tip error, and signal-to-noise ratio (SNR) were measured. Artefact width and needle-tip error correlated with needle material, instrument orientation to B0, and sequence type. Fast spin-echo sequences produced the smallest needle artefacts for all needles, except for the carbon fibre needle (width <3.5 mm, tip error <2 mm) at 45{sup o} to B0. Overall, the proton density-weighted spin-echo sequences had the best CNR (CNR{sub Muscle/Needle} >16.8). Concerning the thermometric gradient echo sequence, artefacts remained <5 mm, and the SNR reached its maximum at an echo time of 15 ms. If needle materials and sequences are accordingly combined, guidance and monitoring of musculoskeletal laser interventions may be feasible in a vertical magnetic field at 1.0T.

  7. A fungal insecticide engineered for fast per os killing of caterpillars has high field efficacy and safety in full-season control of cabbage insect pests.

    PubMed

    Liu, Yong-Jie; Liu, Jing; Ying, Sheng-Hua; Liu, Shu-Sheng; Feng, Ming-Guang

    2013-10-01

    Fungal insecticides developed from filamentous pathogens of insects are notorious for their slow killing action through cuticle penetration, depressing commercial interest and practical application. Genetic engineering may accelerate their killing action but cause ecological risk. Here we show that a Beauveria bassiana formulation, HV8 (BbHV8), engineered for fast per os killing of caterpillars by an insect midgut-acting toxin (Vip3Aa1) overexpressed in conidia has both high field efficacy and safety in full-season protection of cabbage from the damage of an insect pest complex dominated by Pieris rapae larvae, followed by Plutella xylostella larvae and aphids. In two fields repeatedly sprayed during summer, BbHV8 resulted in overall mean efficacies of killing of 71% and 75%, which were similar or close to the 70% and 83% efficacies achieved by commercially recommended emamectin benzoate but much higher than the 31% and 48% efficacies achieved by the same formulation of the parental wild-type strain (WT). Both BbHV8 and WT sprays exerted no adverse effect on a nontarget spider community during the trials, and the sprays did not influence saprophytic fungi in soil samples taken from the field plots during 4 months after the last spray. Strikingly, BbHV8 and the WT showed low fitness when they were released into the environment because both were decreasingly recovered from the field lacking native B. bassiana strains (undetectable 5 months after the spray), and the recovered isolates became much less tolerant to high temperature and UV-B irradiation. Our results highlight for the first time that a rationally engineered fungal insecticide can compete with a chemical counterpart to combat insect pests at an affordable cost and with low ecological risk.

  8. Assessment of Age-Related Morphometric Changes of Subcortical Structures in Healthy People Using Ultra-High Field 7 Tesla Magnetic Resonance Imaging

    PubMed Central

    Wang, Xue-Yuan; Zhao, Lei; Yu, Tao; Qiao, Liang; Ni, Duan-Yu; Zhang, Guo-Jun; Li, Yong-Jie

    2016-01-01

    Objective: To assess the age-related morphometric changes of subcortical structures in healthy people. Materials and Methods: Ultra-high field 7 tesla magnetic resonance (MR) imaging in humans was used to visualize the subcortical structures of healthy young, middle-aged and elderly participants. Using the magnetization-prepared two rapid acquisition gradient echo (MP2RAGE) sequence, we assessed the visibility of the margins of the thalamus and white matter in the thalamus, as well as the anterior commissure (AC) and posterior commissure (PC) length, the maximal height of the thalamus, the half width of the third ventricle and the distance between the AC and the center of the mammillothalamic tract (MTT) at the level of the AC-PC plane. All quantitative data were statistically evaluated. Results: The AC-PC length did not differ significantly among the three groups. The maximal height of the thalamus decreased with age (rs(53) = −0.719, p < 0.001). The half width of the third ventricle (rs(53) = 0.705, p < 0.001) and the distance between the AC and the center of the MTT (rs(53) = 0.485, p < 0.001) increased with age. The distance between the AC and the center of the MTT of the young and the elderly participants differed significantly (p = 0.007). Conclusion: The AC-PC length is not a good candidate for proportional correction during atlas-to-patient registration. The maximal height of the thalamus and the half width of the third ventricle correlated strongly with age, and the MTT position in relation to the AC shifted posteriorly as age increased. These age-related morphometric changes of subcortical structures should be considered in targeting for functional neurosurgery. PMID:27725800

  9. Chemical spray pyrolysis of Tl-Ba-Ca-Cu-O high-T(sub c) superconductors for high-field bitter magnets

    NASA Technical Reports Server (NTRS)

    Derochemont, L. Pierre; Zhang, John G.; Squillante, Michael R.; Hermann, A. M.; Duan, H. M.; Andrews, Robert J.; Kelliher, Warren C.

    1991-01-01

    The deposition of Tl-Ba-Ca-Cu-O thick films by spray pyrolyzing a Ba-Ca-Cu-O precursor film and diffusing thallium into the film to form the superconducting phase is examined. This approach was taken to reduce exposure to thallium and its health and safety hazards. The Tl-Ba-Ca-Cu-O system was selected because it has very attractive features which make it appealing to device and manufacturing engineering. Tl-Ba-Ca-Cu-O will accommodate a number of superconducting phases. This attribute makes it very forgiving to stoichiometric fluctuations in the bulk and film. It has excellent thermal and chemical stability, and appears to be relatively insensitive to chemical impurities. Oxygen is tightly bound into the systems, consequently there is no orthorhombic (conductor) to tetragonal (insulator) transition which would affect a component's lifetime. More significantly, the thallium based superconductors appear to have harder magnetic properties than the other high-Tc oxide ceramics. Estimates using magnetoresistance measurements indicate that at 77 K Tl2Ba2CaCu2O10 will have an upper critical field, H(sub c2) fo 26 Tesla for applied fields parallel to the c-axis and approximately 1000 Tesla for fields oriented in the a-b plane. Results to date have shown that superconducting films can be reproducibly deposited on 100 oriented MgO substrates. One film had a zero resistance temperature of 111.5 K. Furthermore, x ray diffraction analysis of the films showed preferential c-axis orientation parallel to the plane of the substrate. These results have now made it possible to consider the manufacture of a superconducting tape wire which can be configured into a topology useful for high-field magnet designs. The research which leads to the preparation of these films and plans for further development are reviewed.

  10. The alteration of metamict zircon and its role in the remobilization of high-field strength elements in the Georgeville granite, Nova Scotia

    SciTech Connect

    Anderson, A.J.; Wirth, R.; Thomas, R.

    2008-10-02

    The structure and composition of metamict zircon from the Georgeville epizonal A-type granite in the Antigonish Highlands, Nova Scotia, were determined using EMPA, SXRF, LA-ICP-MS, Raman microspectroscopy and TEM data. Individual crystals of zircon are variably altered and consist of four domains distinguished on the basis of texture and composition. Domain A consists of zircon and zirconium oxide nanocrystals in an amorphous matrix and is trace-element-enriched. Replacement of domain A in proximity to microfractures produced a porous and relatively trace-element-poor zircon (domain B) with disseminated Th-U- and Y-enriched inclusions (domain C). Domain D consists of amorphous zirconium silicate that is depleted in trace elements but enriched in Hf. It is found in fractures, together with minor amounts of thorite and thorianite. It Domain D is anhydrous and free of inclusions and pore spaces and has a composition similar to highly crystalline zircon. Micro- and nanoscale element-distribution maps indicate that high-field-strength trace elements in metamict zircon were redistributed during alteration by diffusion and by dissolution-and-reprecipitation processes near microfractures and other fluid channelways. The anomalous chondrite-normalized rare-earth-element patterns and Nd isotopic signature of the granite is attributed largely to the preferential transport and deposition of rare-earth elements during subsolidus re-equilibration of metamict zircon. Hydrothermally deposited zirconium silicate (domain D) has a composition similar to that of highly crystalline Hf-rich zircon but is completely amorphous. This observation emphasizes the need to verify the structural integrity and aqueous durability of hydrothermally deposited zircon before it is used to reconstruct hydrothermal processes.

  11. Sedation Agents Differentially Modulate Cortical and Subcortical Blood Oxygenation: Evidence from Ultra-High Field MRI at 17.2 T

    PubMed Central

    Uhrig, Lynn; Ciobanu, Luisa; Djemai, Boucif; Le Bihan, Denis; Jarraya, Béchir

    2014-01-01

    Background Sedation agents affect brain hemodynamic and metabolism leading to specific modifications of the cerebral blood oxygenation level. We previously demonstrated that ultra-high field (UHF) MRI detects changes in cortical blood oxygenation following the administration of sedation drugs commonly used in animal research. Here we applied the UHF-MRI method to study clinically relevant sedation drugs for their effects on cortical and subcortical (thalamus, striatum) oxygenation levels. Methods We acquired T2*-weighted images of Sprague-Dawley rat brains at 17.2T in vivo. During each MRI session, rats were first anesthetized with isoflurane, then with a second sedative agent (sevoflurane, propofol, midazolam, medetomidine or ketamine-xylazine) after stopping isoflurane. We computed a T2*-oxygenation-ratio that aimed at estimating cerebral blood oxygenation level for each sedative agent in each region of interest: cortex, hippocampus, thalamus and striatum. Results The T2*-oxygenation-ratio was consistent across scan sessions. This ratio was higher with inhalational agents than with intravenous agents. Under sevoflurane and medetomidine, T2*-oxygenation-ratio was homogenous across the brain regions. Intravenous agents (except medetomidine) induced a T2*-oxygenation-ratio imbalance between cortex and subcortical regions: T2*-oxygenation-ratio was higher in the cortex than the subcortical areas under ketamine-xylazine; T2*-oxygenation-ratio was higher in subcortical regions than in the cortex under propofol or midazolam. Conclusion Preclinical UHF MRI is a powerful method to monitor the changes in cerebral blood oxygenation level induced by sedative agents across brain structures. This approach also allows for a classification of sedative agents based on their differential effects on cerebral blood oxygenation level. PMID:25050866

  12. Experimental research of high field pinning centers in 2% C doped MgB2 wires at 20 K and 25 K

    NASA Astrophysics Data System (ADS)

    Gajda, D.; Morawski, A.; Zaleski, A. J.; Häßler, W.; Nenkov, K.; Małecka, M.; Rindfleisch, M. A.; Hossain, M. S. A.; Tomsic, M.

    2016-09-01

    High field pinning centers in MgB2 doped with 2 at. % carbon under a low and a high hot isostatic pressures have been investigated by transport measurements. The field dependence of the transport critical current density was analyzed within the different pinning mechanisms: surface pinning, point pinning, and pinning due to spatial variation in the Ginzburg-Landau parameter (Δκ pinning). Research indicates that a pressure of 1 GPa allows similar pinning centers to Δκ pinning centers to be obtained. This pinning is very important, because it makes it possible to increase the critical current density in high magnetic fields at 20 K and 25 K. Our results indicate that the δTc and δl pinning mechanisms, which are due to a spatial variation in the critical temperature (Tc) and the mean free path, l, respectively, create dislocations. The high density of dislocations with inhomogeneous distribution in the structure of the superconducting material creates the δl pinning mechanism. The low density of dislocations with inhomogeneous distribution creates the δTc pinning mechanism. Research indicates that the hot isostatic pressure process makes it possible to obtain a high dislocation density with a homogeneous distribution. This allows us to obtain the δTc pinning mechanism in MgB2 wires. In addition, a high pressure increases the crossover field from the single vortex to the small vortex bundle regime (Bsb) and improves the δTc pinning mechanism. Our research has proved that a high pressure significantly increases the crossover field from the small bundle to the thermal regime (Bth), with only a modest decrease in Tc of 1.5 K, decreases the thermal fluctuations, increases the irreversibility magnetic field (Birr) and the upper critical field (Bc2) in the temperature range from 4.2 K to 25 K, and reduces Birr and Bc2 above 25 K.

  13. High-field 1H T1 and T2 NMR relaxation time measurements of H2O in homeopathic preparations of quartz, sulfur, and copper sulfate

    NASA Astrophysics Data System (ADS)

    Baumgartner, Stephan; Wolf, Martin; Skrabal, Peter; Bangerter, Felix; Heusser, Peter; Thurneysen, André; Wolf, Ursula

    2009-09-01

    Quantitative meta-analyses of randomized clinical trials investigating the specific therapeutic efficacy of homeopathic remedies yielded statistically significant differences compared to placebo. Since the remedies used contained mostly only very low concentrations of pharmacologically active compounds, these effects cannot be accounted for within the framework of current pharmacology. Theories to explain clinical effects of homeopathic remedies are partially based upon changes in diluent structure. To investigate the latter, we measured for the first time high-field (600/500 MHz) 1H T1 and T2 nuclear magnetic resonance relaxation times of H2O in homeopathic preparations with concurrent contamination control by inductively coupled plasma mass spectrometry (ICP-MS). Homeopathic preparations of quartz (10 c-30 c, n = 21, corresponding to iterative dilutions of 100-10-100-30), sulfur (13 x-30 x, n = 18, 10-13-10-30), and copper sulfate (11 c-30 c, n = 20, 100-11-100-30) were compared to n = 10 independent controls each (analogously agitated dilution medium) in randomized and blinded experiments. In none of the samples, the concentration of any element analyzed by ICP-MS exceeded 10 ppb. In the first measurement series (600 MHz), there was a significant increase in T1 for all samples as a function of time, and there were no significant differences between homeopathic potencies and controls. In the second measurement series (500 MHz) 1 year after preparation, we observed statistically significant increased T1 relaxation times for homeopathic sulfur preparations compared to controls. Fifteen out of 18 correlations between sample triplicates were higher for controls than for homeopathic preparations. No conclusive explanation for these phenomena can be given at present. Possible hypotheses involve differential leaching from the measurement vessel walls or a change in water molecule dynamics, i.e., in rotational correlation time and/or diffusion. Homeopathic preparations

  14. Identification of N-nitrosamines in treated drinking water using nanoelectrospray ionization high-field asymmetric waveform ion mobility spectrometry with quadrupole time-of-flight mass spectrometry.

    PubMed

    Zhao, Yuan Yuan; Liu, Xin; Boyd, Jessica M; Qin, Feng; Li, Jianjun; Li, Xing-Fang

    2009-01-01

    We report a nanoelectrospray ionization (nESI) with high-field asymmetric waveform ion mobility spectrometry (FAIMS) and tandem mass spectrometry (MS-MS) method for determination of small molecules of m/z 50 to 200 and its potential application in environmental analysis. Integration of nESI with FAIMS and MS-MS combines the advantages of these three techniques into one method. The nESI provides efficient sample introduction and ionization and allows for collection of multiple data from only microliters of samples. The FAIMS provides rapid separation, reduces or eliminates background interference, and improves the signal-to-noise ratio as much as 10-fold over nESI-MS-MS. The tandem quadrupole time-of-flight MS detection provides accurate mass and mass spectral measurements for structural identification. Characteristics of FAIMS compensation voltage (CV) spectra of seven nitrosamines, N-nitrosodimethylamine (NDMA), N-nitrosomethylethylamine (NMEA), N-nitrosodiethylamine (NDEA), N-nitrosodi-n-propylamine (NDPA), N-nitrosodi-n-butylamine (NDBA), N-nitrosopiperidine (NPip), and N-nitrosopyrrolidine (NPyr), were analyzed. The optimal CV of the nitrosamines (at DV -4000 V) were: -1.6 V, NDBA; 2.6 V, NDPA; 6.6 V, NPip; 8.8 V, NDEA; 13.2 V, NPyr; 14.4 V, NMEA; and 19.4 V, NDMA. Fragmentation patterns of the seven nitrosamines in the nESI-FAIMS-MS-MS were also obtained. The specific CV and MS-MS spectra resulted in positive identification of NPyr and NPip in a treated water sample, demonstrating the potential application of this technique in environmental analysis.

  15. The Travelling-Wave Primate System: A New Solution for Magnetic Resonance Imaging of Macaque Monkeys at 7 Tesla Ultra-High Field

    PubMed Central

    Herrmann, Tim; Mallow, Johannes; Plaumann, Markus; Luchtmann, Michael; Stadler, Jörg; Mylius, Judith; Brosch, Michael; Bernarding, Johannes

    2015-01-01

    Introduction Neuroimaging of macaques at ultra-high field (UHF) is usually conducted by combining a volume coil for transmit (Tx) and a phased array coil for receive (Rx) tightly enclosing the monkey’s head. Good results have been achieved using vertical or horizontal magnets with implanted or near-surface coils. An alternative and less costly approach, the travelling-wave (TW) excitation concept, may offer more flexible experimental setups on human whole-body UHF magnetic resonance imaging (MRI) systems, which are now more widely available. Goal of the study was developing and validating the TW concept for in vivo primate MRI. Methods The TW Primate System (TWPS) uses the radio frequency shield of the gradient system of a human whole-body 7 T MRI system as a waveguide to propagate a circularly polarized B1 field represented by the TE11 mode. This mode is excited by a specifically designed 2-port patch antenna. For receive, a customized neuroimaging monkey head receive-only coil was designed. Field simulation was used for development and evaluation. Signal-to-noise ratio (SNR) was compared with data acquired with a conventional monkey volume head coil consisting of a homogeneous transmit coil and a 12-element receive coil. Results The TWPS offered good image homogeneity in the volume-of-interest Turbo spin echo images exhibited a high contrast, allowing a clear depiction of the cerebral anatomy. As a prerequisite for functional MRI, whole brain ultrafast echo planar images were successfully acquired. Conclusion The TWPS presents a promising new approach to fMRI of macaques for research groups with access to a horizontal UHF MRI system. PMID:26066653

  16. Comparison of noncontrast computed tomography and high-field magnetic resonance imaging in the evaluation of Great Danes with cervical spondylomyelopathy.

    PubMed

    Martin-Vaquero, Paula; da Costa, Ronaldo C; Drost, Wm Tod

    2014-01-01

    Computed tomography (CT) provides excellent bony detail, whereas magnetic resonance (MR) imaging is superior in evaluating the neural structures. The purpose of this prospective study was to assess interobserver and intermethod agreement in the evaluation of cervical vertebral column morphology and lesion severity in Great Danes with cervical spondylomyelopathy by use of noncontrast CT and high-field MR imaging. Fifteen client-owned affected Great Danes were enrolled. All dogs underwent noncontrast CT under sedation and MR imaging under general anesthesia of the cervical vertebral column. Three observers independently evaluated the images to determine the main site of spinal cord compression, direction and cause of the compression, articular process joint characteristics, and presence of foraminal stenosis. Overall intermethod agreement, intermethod agreement for each observer, overall interobserver agreement, and interobserver agreement between pairs of observers were calculated by use of kappa (κ) statistics. The highest overall intermethod agreements were obtained for the main site of compression and direction of compression with substantial agreements (κ = 0.65 and 0.62, respectively), whereas the lowest was obtained for right-sided foraminal stenosis (κ = 0.39, fair agreement). For both imaging techniques, the highest and lowest interobserver agreements were recorded for the main site of compression and degree of articular joint proliferation, respectively. While different observers frequently agree on the main site of compression using both imaging techniques, there is considerable variation between modalities and among observers when assessing articular process characteristics and foraminal stenosis. Caution should be exerted when comparing image interpretations from multiple observers.

  17. Medical image file formats.

    PubMed

    Larobina, Michele; Murino, Loredana

    2014-04-01

    Image file format is often a confusing aspect for someone wishing to process medical images. This article presents a demystifying overview of the major file formats currently used in medical imaging: Analyze, Neuroimaging Informatics Technology Initiative (Nifti), Minc, and Digital Imaging and Communications in Medicine (Dicom). Concepts common to all file formats, such as pixel depth, photometric interpretation, metadata, and pixel data, are first presented. Then, the characteristics and strengths of the various formats are discussed. The review concludes with some predictive considerations about the future trends in medical image file formats.

  18. Medical image file formats.

    PubMed

    Larobina, Michele; Murino, Loredana

    2014-04-01

    Image file format is often a confusing aspect for someone wishing to process medical images. This article presents a demystifying overview of the major file formats currently used in medical imaging: Analyze, Neuroimaging Informatics Technology Initiative (Nifti), Minc, and Digital Imaging and Communications in Medicine (Dicom). Concepts common to all file formats, such as pixel depth, photometric interpretation, metadata, and pixel data, are first presented. Then, the characteristics and strengths of the various formats are discussed. The review concludes with some predictive considerations about the future trends in medical image file formats. PMID:24338090

  19. Star Formation for Predictive Primordial Galaxy Formation

    NASA Astrophysics Data System (ADS)

    Milosavljević, Miloš; Safranek-Shrader, Chalence

    The elegance of inflationary cosmology and cosmological perturbation theory ends with the formation of the first stars and galaxies, the initial sources of light that launched the phenomenologically rich process of cosmic reionization. Here we review the current understanding of early star formation, emphasizing unsolved problems and technical challenges. We begin with the first generation of stars to form after the Big Bang and trace how they influenced subsequent star formation. The onset of chemical enrichment coincided with a sharp increase in the overall physical complexity of star forming systems. Ab-initio computational treatments are just now entering the domain of the predictive and are establishing contact with local observations of the relics of this ancient epoch.

  20. A high-field 3He metastability exchange optical pumping polarizer operating in a 1.5 T medical scanner for lung magnetic resonance imaging

    NASA Astrophysics Data System (ADS)

    Collier, G.; Pałasz, T.; Wojna, A.; Głowacz, B.; Suchanek, M.; Olejniczak, Z.; Dohnalik, T.

    2013-05-01

    After being hyperpolarized using the technique of Metastability Exchange Optical Pumping (MEOP), 3He can be used as a contrast agent for lung magnetic resonance imaging (MRI). MEOP is usually performed at low magnetic field (˜1 mT) and low pressure (˜1 mbar), which results in a low magnetization production rate. Polarization preserving compression with a compression ratio of order 1000 is also required. It was demonstrated in sealed cells that high nuclear polarization values can be obtained at higher pressures with MEOP, if performed at high magnetic field (non-standard conditions). In this work, the feasibility of building a high-field polarizer that operates within a commercial 1.5 T scanner was evaluated. Preliminary measurements of nuclear polarization with sealed cells filled at different 3He gas pressures (1.33 to 267 mbar) were performed. The use of an annular shape for the laser beam increased by 25% the achievable nuclear polarization equilibrium value (Meq) at 32 and 67 mbar as compared to a Gaussian beam shape. Meq values of 66.4% and 31% were obtained at 32 and 267 mbar, respectively, and the magnetization production rate was increased by a factor of 10 compared to the best results obtained under standard conditions. To study the reproducibility of the method in a polarizing system, the same experiments were performed with small cells connected to a gas handling system. Despite careful cleaning procedure, the purity of the 3He gas could not be matched to that of the sealed cells. Consequently, the polarization build-up times were approximately 3 times longer in the 20-30 mbar range of pressure than those obtained for the 32 mbar sealed cell. However, reasonable Meq values of 40%-60% were achieved in a 90 ml open cell. Based on these findings, a novel compact polarizing system was designed and built. Its typical output is a 3He gas flow rate of 15 sccm with a polarization of 33%. In-vivo lung MRI ventilation images (Signal to Noise Ratio (SNR) of

  1. Equilibrium drives of the low and high field side n  =  2 plasma response and impact on global confinement

    NASA Astrophysics Data System (ADS)

    Paz-Soldan, C.; Logan, N. C.; Haskey, S. R.; Nazikian, R.; Strait, E. J.; Chen, X.; Ferraro, N. M.; King, J. D.; Lyons, B. C.; Park, J.-K.

    2016-05-01

    The nature of the multi-modal n  =  2 plasma response and its impact on global confinement is studied as a function of the axisymmetric equilibrium pressure, edge safety factor, collisionality, and L-versus H-mode conditions. Varying the relative phase (Δ {φ\\text{UL}} ) between upper and lower in-vessel coils demonstrates that different n  =  2 poloidal spectra preferentially excite different plasma responses. These different plasma response modes are preferentially detected on the tokamak high-field side (HFS) or low-field side (LFS) midplanes, have different radial extents, couple differently to the resonant surfaces, and have variable impacts on edge stability and global confinement. In all equilibrium conditions studied, the observed confinement degradation shares the same Δ {φ\\text{UL}} dependence as the coupling to the resonant surfaces given by both ideal (IPEC) and resistive (MARS-F) MHD computation. Varying the edge safety factor shifts the equilibrium field-line pitch and thus the Δ {φ\\text{UL}} dependence of both the global confinement and the n  =  2 magnetic response. As edge safety factor is varied, modeling finds that the HFS response (but not the LFS response), the resonant surface coupling, and the edge displacements near the X-point all share the same Δ {φ\\text{UL}} dependence. The LFS response magnitude is strongly sensitive to the core pressure and is insensitive to the collisionality and edge safety factor. This indicates that the LFS measurements are primarily sensitive to a pressure-driven kink-ballooning mode that couples to the core plasma. MHD modeling accurately reproduces these (and indeed all) LFS experimental trends and supports this interpretation. In contrast to the LFS, the HFS magnetic response and correlated global confinement impact is unchanged with plasma pressure, but is strongly reduced in high collisionality conditions in both H- and L-mode. This experimentally suggests the bootstrap

  2. Tropical cyclone formation

    SciTech Connect

    Montgomery, M.T.; Farrell, B.F. )

    1993-01-15

    The physics of tropical cyclone formation is not well understood, and more is known about the mature hurricane than the formative mechanisms that produce it. It is believed part of the reason for this can be traced to insufficient upper-level atmospheric data. Recent observations suggest that tropical cyclones are initiated by asymmetric interactions associated with migratory upper-level potential vorticity disturbances and low-level disturbances. Favored theories of cyclones formation, however, focus on internal processes associated with cumulus convection and/or air-sea interaction. This work focuses on external mechanisms of cyclone formation and, using both a two- and three-dimensional moist geostrophic momentum model, investigates the role of upper-level potential vorticity disturbances on the formation process. A conceptual model of tropical cyclone formation is proposed, and implications of the theory are discussed. 71 refs., 5 figs., 1 tab.

  3. Processing and characterization of superconducting solenoids made of Bi-2212/Ag-alloy multifilament round wire for high field magnet applications

    NASA Astrophysics Data System (ADS)

    Chen, Peng

    As the only high temperature superconductor with round wire (RW) geometry, Bi2Sr2CaCu2O8+x (Bi-2212) superconducting wire has the advantages of being multi-filamentary, macroscopically isotropic and twistable. With overpressure (OP) processing techniques recently developed by our group at the National High Magnetic Field Laboratory (NHMFL), the engineering current density (Je) of Bi-2212 RW can be dramatically increased. For example, Je of more than 600 A/mm 2 (4.2 K and 20 T) is achieved after 100 bar OP processing. With these intrinsically beneficial properties and recent processing progress, Bi-2212 RW has become very attractive for high field magnet applications, especially for nuclear magnetic resonance (NMR) magnets and accelerator magnets etc. This thesis summarizes my graduate study on Bi-2212 solenoids for high field and high homogeneity NMR magnet applications, which mainly includes performance study of Bi-2212 RW insulations, 1 bar and OP processing study of Bi-2212 solenoids, and development of superconducting joints between Bi-2212 RW conductors. Electrical insulation is one of the key components of Bi-2212 coils to provide sufficient electrical standoff within coil winding pack. A TiO 2/polymer insulation offered by nGimat LLC was systematically investigated by differential thermal analysis (DTA), thermo-gravimetric analysis (TGA), scanning electron microscopy (SEM), dielectric property measurements, and transport critical current (Ic) property measurements. About 29% of the insulation by weight is polymer. When the Bi-2212 wire is fully heat treated, this decomposes with slow heating to 400 °C in flowing O2. After the full reaction, we found that the TiO2 did not degrade the critical current properties, adhered well to the conductor, and provided a breakdown voltage of more than 100 V. A Bi-2212 RW wound solenoid coil was built using this insulation being offered by nGimat LLC. The coil resistance was constant through coil winding, polymer burn

  4. Simple Ontology Format (SOFT)

    2011-10-01

    Simple Ontology Format (SOFT) library and file format specification provides a set of simple tools for developing and maintaining ontologies. The library, implemented as a perl module, supports parsing and verification of the files in SOFt format, operations with ontologies (adding, removing, or filtering of entities), and converting of ontologies into other formats. SOFT allows users to quickly create ontologies using only a basic text editor, verify it, and portray it in a graph layoutmore » system using customized styles.« less

  5. GLOBAL STAR FORMATION REVISITED

    SciTech Connect

    Silk, Joseph; Norman, Colin E-mail: norman@stsci.edu

    2009-07-20

    A general treatment of disk star formation is developed from a dissipative multiphase model, with the dominant dissipation due to cloud collisions. The Schmidt-Kennicutt (SK) law emerges naturally for star-forming disks and starbursts. We predict that there should be an inverse correlation between Tully-Fisher law and SK law residuals. The model is extended to include a multiphase treatment of supernova feedback that leads to a turbulent pressure-regulated generalization of the star formation law and is applicable to gas-rich starbursts. Enhanced pressure, as expected in merger-induced star formation, enhances star formation efficiency. An upper limit is derived for the disk star formation rate in starbursts that depends on the ratio of global ISM to cloud pressures. We extend these considerations to the case where the interstellar gas pressure in the inner galaxy is dominated by outflows from a central active galactic nucleus (AGN). During massive spheroid formation, AGN-driven winds trigger star formation, resulting in enhanced supernova feedback and outflows. The outflows are comparable to the AGN-boosted star formation rate and saturate in the super-Eddington limit. Downsizing of both SMBH and spheroids is a consequence of AGN-driven positive feedback. Bondi accretion feeds the central black hole with a specific accretion rate that is proportional to the black hole mass. AGN-enhanced star formation is mediated by turbulent pressure and relates spheroid star formation rate to black hole accretion rate. The relation between black hole mass and spheroid velocity dispersion has a coefficient (Salpeter time to gas consumption time ratio) that provides an arrow of time. Highly efficient, AGN-boosted star formation can occur at high redshift.

  6. [Measuring thrombin formation].

    PubMed

    Hemker, H C

    2016-01-01

    Measurement of thrombin formation makes it possible to estimate the risk of haemorrhage or thrombosis much more accurately than by using clotting time. This new technique allows better monitoring of the effect of prophylactic and therapeutic anticoagulant therapy. Thrombin formation is, however, not yet routinely measured. PMID:27650017

  7. Ice Formation on Wings

    NASA Technical Reports Server (NTRS)

    Ritz, L

    1939-01-01

    This report makes use of the results obtained in the Gottingen ice tunnel in which the atmospheric conditions are simulated and the process of ice formation photographed. The effect of ice formation is threefold: 1) added weight to the airplane; 2) a change in the lift and drag forces; 3) a change in the stability characteristics.

  8. School Formative Feedback Systems

    ERIC Educational Resources Information Center

    Halverson, Richard

    2010-01-01

    Data-driven instructional improvement relies on developing coherent systems that allow school staff to generate, interpret, and act upon quality formative information on students and school programs. This article offers a formative feedback system model that captures how school leaders and teachers structure artifacts and practices to create…

  9. Entering the Formative Years

    ERIC Educational Resources Information Center

    Powers, Keith

    2011-01-01

    This article discusses formative assessment--classroom strategies that ensure students are understanding music concepts. Unlike summative assessments (end-of-process evaluations like final exams, SATs, or auditions), formative assessments need to be non-threatening, helpful, and most of all, effective. The process starts with a teacher…

  10. Formative Assessment Probes

    ERIC Educational Resources Information Center

    Eberle, Francis; Keeley, Page

    2008-01-01

    Formative assessment probes can be effective tools to help teachers build a bridge between students' initial ideas and scientific ones. In this article, the authors describe how using two formative assessment probes can help teachers determine the extent to which students make similar connections between developing a concept of matter and a…

  11. Detailed Investigation of Ion Exchange in Ball Milled LiH+MgB2 System using Ultra-High Field NMR Spectroscopy

    SciTech Connect

    Hu, Jian Z.; Kwak, Ja Hun; Yang, Zhenguo; Wan, Xiufeng; Shaw, Leonard D.

    2010-06-01

    The present study with the detailed 1H-6Li cross polarization NMR analysis confirms the formation of a ternary compound, (Mg1-xLi2x)B2, during ball milling of LiH + ½ MgB2 at room temperature. The 6Li sites in (Mg1-xLi2x)B2 exhibit spinning sidebands (SSBs), whereas the 6Li sites in LiH do not. The SSBs and the very short spin-lattice relaxation time manifested by the 6Li sites in (Mg1-xLi2x)B2 indicate that the Li ions in (Mg1-xLi2x)B2 are located between the layered boron structures and close to Mg ions. The formation of (Mg1-xLi2x)B2 explains the previous observation that the LiH + ½ MgB2 mixture ball milled effectively has a greatly enhanced hydriding kinetics at temperatures below the melting point of LiBH4.

  12. Intergalactic Star Formation

    NASA Astrophysics Data System (ADS)

    Boquien, Médéric

    2007-11-01

    The work presented here is about star formation in the unusual environment of collisional debris studied for the first time as such. These peculiar regions have an interstellar medium, and in particular a metallicity, similar to that of star forming regions in galactic discs while not undergoing similar environment effects such as density waves in the spiral arms for instance. This study has been conducted with a selection of exceptional systems that have ejected large quantities of gas into the intergalactic medium while also showing some intergalactic star forming regions. Principal Investigator as well as archive spectroscopy and imaging from multi-wavelength observations ranging from far ultraviolet to mid-infrared have been used. Withal a model has been built in order to reproduce the spectral energy distributions of intergalactic star forming regions and constrain the star formation histories, their extinctions and their fraction of stars coming from the parent galaxies' discs. Comparisons have been performed on the estimation of star formation rates between infrared, Halpha and ultraviolet wavelengths. This thesis has brought the following main new results: * some regions seem to be deprived of any old stellar population, and these are ideal laboratories in which to study star formation ; * the mid-infrared star formation rate estimator is as reliable as it is in spiral galaxies ; * the scatter in the estimation of star formation rates in various bands is similar to that of spiral galaxies and is mainly due to age effects ; * the combination of the extinction uncorrected Halpha line with mid-infrared yields a good estimation of the actual star formation rate ; * an important part of star formation, which can be as high as 85%, takes place in the intergalactic medium showing that in a young universe, in which this type of system is much more common than in the nearby universe, star formation from collisional debris can be an important factor of enrichment of

  13. Sparse Image Format

    2007-04-12

    The Sparse Image Format (SIF) is a file format for storing spare raster images. It works by breaking an image down into tiles. Space is savid by only storing non-uniform tiles, i.e. tiles with at least two different pixel values. If a tile is completely uniform, its common pixel value is stored instead of the complete tile raster. The software is a library in the C language used for manipulating files in SIF format. Itmore » supports large files (> 2GB) and is designed to build in Windows and Linux environments.« less

  14. Sparse Image Format

    SciTech Connect

    Eads, Damian Ryan

    2007-04-12

    The Sparse Image Format (SIF) is a file format for storing spare raster images. It works by breaking an image down into tiles. Space is savid by only storing non-uniform tiles, i.e. tiles with at least two different pixel values. If a tile is completely uniform, its common pixel value is stored instead of the complete tile raster. The software is a library in the C language used for manipulating files in SIF format. It supports large files (> 2GB) and is designed to build in Windows and Linux environments.

  15. Plant Formate Dehydrogenase

    SciTech Connect

    John Markwell

    2005-01-10

    The research in this study identified formate dehydrogenase, an enzyme that plays a metabolic role on the periphery of one-carbon metabolism, has an unusual localization in Arabidopsis thaliana and that the enzyme has an unusual kinetic plasticity. These properties make it possible that this enzyme could be engineered to attempt to engineer plants with an improved photosynthetic efficiency. We have produced transgenic Arabidopsis and tobacco plants with increased expression of the formate dehydrogenase enzyme to initiate further studies.

  16. Display formats manual

    NASA Technical Reports Server (NTRS)

    Runnels, R. L.

    1973-01-01

    The standards and procedures for the generation of operational display formats to be used in the Mission Control Center (MCC) display control system are presented. The required effort, forms, and fundamentals for the design, specifications, and production of display formats are identified. The principles of display design and system constraints controlling the creation of optimum operational displays for mission control are explained. The basic two types of MCC display systems for presenting information are described.

  17. Autonomous Formation Flight

    NASA Technical Reports Server (NTRS)

    Schkolnik, Gerard S.; Cobleigh, Brent

    2004-01-01

    NASA's Strategic Plan for the Aerospace Technology Enterprise includes ambitious objectives focused on affordable air travel, reduced emissions, and expanded aviation-system capacity. NASA Dryden Flight Research Center, in cooperation with NASA Ames Research Center, the Boeing Company, and the University of California, Los Angeles, has embarked on an autonomous-formation-flight project that promises to make significant strides towards these goals. For millions of years, birds have taken advantage of the aerodynamic benefit of flying in formation. The traditional "V" formation flown by many species of birds (including gulls, pelicans, and geese) enables each of the trailing birds to fly in the upwash flow field that exists just outboard of the bird immediately ahead in the formation. The result for each trailing bird is a decrease in induced drag and thus a reduction in the energy needed to maintain a given speed. Hence, for migratory birds, formation flight extends the range of the system of birds over the range of birds flying solo. The Autonomous Formation Flight (AFF) Project is seeking to extend this symbiotic relationship to aircraft.

  18. The Q Exactive HF, a Benchtop Mass Spectrometer with a Pre-filter, High-performance Quadrupole and an Ultra-high-field Orbitrap Analyzer*

    PubMed Central

    Scheltema, Richard Alexander; Hauschild, Jan-Peter; Lange, Oliver; Hornburg, Daniel; Denisov, Eduard; Damoc, Eugen; Kuehn, Andreas; Makarov, Alexander; Mann, Matthias

    2014-01-01

    The quadrupole Orbitrap mass spectrometer (Q Exactive) made a powerful proteomics instrument available in a benchtop format. It significantly boosted the number of proteins analyzable per hour and has now evolved into a proteomics analysis workhorse for many laboratories. Here we describe the Q Exactive Plus and Q Exactive HF mass spectrometers, which feature several innovations in comparison to the original Q Exactive instrument. A low-resolution pre-filter has been implemented within the injection flatapole, preventing unwanted ions from entering deep into the system, and thereby increasing its robustness. A new segmented quadrupole, with higher fidelity of isolation efficiency over a wide range of isolation windows, provides an almost 2-fold improvement of transmission at narrow isolation widths. Additionally, the Q Exactive HF has a compact Orbitrap analyzer, leading to higher field strength and almost doubling the resolution at the same transient times. With its very fast isolation and fragmentation capabilities, the instrument achieves overall cycle times of 1 s for a top 15 to 20 higher energy collisional dissociation method. We demonstrate the identification of 5000 proteins in standard 90-min gradients of tryptic digests of mammalian cell lysate, an increase of over 40% for detected peptides and over 20% for detected proteins. Additionally, we tested the instrument on peptide phosphorylation enriched samples, for which an improvement of up to 60% class I sites was observed. PMID:25360005

  19. Monitoring the Growth of an Orthotopic Tumour Xenograft Model: Multi-Modal Imaging Assessment with Benchtop MRI (1T), High-Field MRI (9.4T), Ultrasound and Bioluminescence

    PubMed Central

    Stuckey, Daniel J.; David, Anna L.; Pedley, R. Barbara; Lythgoe, Mark F.; Siow, Bernard; Walker-Samuel, Simon

    2016-01-01

    Background Research using orthotopic and transgenic models of cancer requires imaging methods to non-invasively quantify tumour burden. As the choice of appropriate imaging modality is wide-ranging, this study aimed to compare low-field (1T) magnetic resonance imaging (MRI), a novel and relatively low-cost system, against established preclinical techniques: bioluminescence imaging (BLI), ultrasound imaging (US), and high-field (9.4T) MRI. Methods A model of colorectal metastasis to the liver was established in eight mice, which were imaged with each modality over four weeks post-implantation. Tumour burden was assessed from manually segmented regions. Results All four imaging systems provided sufficient contrast to detect tumours in all of the mice after two weeks. No significant difference was detected between tumour doubling times estimated by low-field MRI, ultrasound imaging or high-field MRI. A strong correlation was measured between high-field MRI estimates of tumour burden and all the other modalities (p < 0.001, Pearson). Conclusion These results suggest that both low-field MRI and ultrasound imaging are accurate modalities for characterising the growth of preclinical tumour models. PMID:27223614

  20. High field NMR spectroscopy and FTICR mass spectrometry: powerful discovery tools for the molecular level characterization of marine dissolved organic matter from the South Atlantic Ocean

    NASA Astrophysics Data System (ADS)

    Hertkorn, N.; Harir, M.; Koch, B. P.; Michalke, B.; Grill, P.; Schmitt-Kopplin, P.

    2012-01-01

    and phenols, six-membered nitrogen heterocycles were found prominent contributors to the downfield region of proton chemical shift (δH > 8 ppm). Specifically, a rather confined HSQC cross peak at δH/δC = 8.2/164 ppm indicated a limited set of nitrogen heterocycles with several nitrogen atoms in analogy to RNA derivatives present in all four marine DOM. Appreciable amounts of extended HSQC and TOCSY cross peaks derived from various key polycyclic aromatic hydrocarbon substructures suggested the presence of previously proposed but NMR invisible thermogenic organic matter (TMOC) in marine DOM at all water depths. Eventually, olefinic unsaturation in marine DOM will be more directly traceable to ultimate biogenic precursors than aromatic unsaturation of which a substantial fraction originates from an aged material which from the beginning was subjected to complex and less specific biogeochemical reactions like thermal decomposition. The variance in molecular mass as indicated from Fourier transform ion cyclotron resonance (FTICR) mass spectra was limited and could not satisfactorily explain the observed disparity in NMR transverse relaxation of the four marine DOM samples. Likewise, the presence of metal ions in isolated marine DOM remained near constant or declined from surface to depth for important paramagnetic ions like Mn, Cr, Fe, Co, Ni and Cu. Iron in particular, a strong complexing paramagnetic ion, was found most abundant by a considerable margin in surface (FISH) marine DOM for which well resolved COSY cross peaks were observed. Hence, facile relationships between metal content of isolated DOM (which does not reflect authentic marine DOM metal content) and transverse NMR relaxation were not observed. High field (12 T) negative electrospray ionization FTICR mass spectra showed at first view rather conforming mass spectra for all four DOM samples with abundant CHO, CHNO, CHOS and CHNOS molecular series with slightly increasing numbers of mass peaks from surface

  1. Positronium Formation in Muscle

    PubMed Central

    Gustafson, D. R.

    1970-01-01

    Positronium formation in muscle at +4°C and -4°C was examined by the measurement of the angular correlation of positron annihilation radiation. Since the positronium formation rate in ice is considerably higher than it is in water, there should be a comparable increase in the positronium formation rate in muscle tissue if recent speculation that cellular water is ordered in a semicrystalline icelike state is correct. Comparison of the angular correlation from muscle at +4°C with that from water at +4°C shows no enhancement of the positronium formation rate. Frozen muscle at -4°C shows an enhancement of the positronium formation rate of approximately half that found in ice at -4°C, indicating that most cellular water undergoes a normal water-ice transition when frozen. It is concluded therefore that cell water in muscle is not ordered in a hexagonal icelike structure. While the results are consistent with the hypothesis that cell water is in the liquid state, the hypothesis that cell water is ordered in an undetermined close packed structure which transforms to the hexagonal ice structure at or near 0°C cannot be ruled out. PMID:5436881

  2. Planet Formation and Habitability

    NASA Astrophysics Data System (ADS)

    alibert, yann

    2016-04-01

    Extrasolar planetary systems show an extreme diversity in mass and orbital architecture, and, very likely, in habitability. Explaining this diversity is one of the key challenges for theoretical models and requires understanding the formation, composition and evolution of planetary systems from the stage of the protoplanetary disk up to the full mature planetary system. I will review in this contribution the different models of planet formation and how they can be related to planetary habitability. In a first part, I will review the main planetary system formation models, and how, from these models, the composition of planets can be predicted. In a second part, I will link the results of these early phases of planetary systems, to the potential planetary habitability. Finally, I will show how it is possible, from transit observations, to put constraints on the water content of extrasolar planets.

  3. Gaussian entanglement of formation

    SciTech Connect

    Wolf, M.M.; Giedke, G.; Krueger, O.; Werner, R. F.; Cirac, J.I.

    2004-05-01

    We introduce a Gaussian version of the entanglement of formation adapted to bipartite Gaussian states by considering decompositions into pure Gaussian states only. We show that this quantity is an entanglement monotone under Gaussian operations and provide a simplified computation for states of arbitrary many modes. For the case of one mode per site the remaining variational problem can be solved analytically. If the considered state is in addition symmetric with respect to interchanging the two modes, we prove additivity of the considered entanglement measure. Moreover, in this case and considering only a single copy, our entanglement measure coincides with the true entanglement of formation.

  4. Isolating Triggered Star Formation

    SciTech Connect

    Barton, Elizabeth J.; Arnold, Jacob A.; Zentner, Andrew R.; Bullock, James S.; Wechsler, Risa H.; /KIPAC, Menlo Park /SLAC

    2007-09-12

    Galaxy pairs provide a potentially powerful means of studying triggered star formation from galaxy interactions. We use a large cosmological N-body simulation coupled with a well-tested semi-analytic substructure model to demonstrate that the majority of galaxies in close pairs reside within cluster or group-size halos and therefore represent a biased population, poorly suited for direct comparison to 'field' galaxies. Thus, the frequent observation that some types of galaxies in pairs have redder colors than 'field' galaxies is primarily a selection effect. We use our simulations to devise a means to select galaxy pairs that are isolated in their dark matter halos with respect to other massive subhalos (N= 2 halos) and to select a control sample of isolated galaxies (N= 1 halos) for comparison. We then apply these selection criteria to a volume-limited subset of the 2dF Galaxy Redshift Survey with M{sub B,j} {le} -19 and obtain the first clean measure of the typical fraction of galaxies affected by triggered star formation and the average elevation in the star formation rate. We find that 24% (30.5 %) of these L* and sub-L* galaxies in isolated 50 (30) h{sup -1} kpc pairs exhibit star formation that is boosted by a factor of {approx}> 5 above their average past value, while only 10% of isolated galaxies in the control sample show this level of enhancement. Thus, 14% (20 %) of the galaxies in these close pairs show clear triggered star formation. Our orbit models suggest that 12% (16%) of 50 (30) h{sup -1} kpc close pairs that are isolated according to our definition have had a close ({le} 30 h{sup -1} kpc) pass within the last Gyr. Thus, the data are broadly consistent with a scenario in which most or all close passes of isolated pairs result in triggered star formation. The isolation criteria we develop provide a means to constrain star formation and feedback prescriptions in hydrodynamic simulations and a very general method of understanding the importance of

  5. Technobabble: File Formats.

    ERIC Educational Resources Information Center

    Wilson, Bradley

    1999-01-01

    Considers the confusion of over 20 different kinds of graphics programs. Briefly distinguishes between some of the more popular graphics formats (Photoshop, TIFF, JPEG, GIF, PICT, and EPS), and describes the benefits and disadvantages of each in the context of journalism education. (SC)

  6. Formation of planetesimals

    NASA Technical Reports Server (NTRS)

    Weidenschilling, Stuart J.

    1991-01-01

    Formation of planetesimals is discussed. The following subject areas are covered: (1) nebular structure; (2) aerodynamics of the solid bodies in the nebula; (3) problems with gravitational instability; (4) particle growth by coagulation; properties of fractal aggregates; and (5) coagulation and settling of fractal aggregates.

  7. Carrascolendas: A Formative Evaluation.

    ERIC Educational Resources Information Center

    Laosa, Luis M.

    A formative research project sought to test viewer reactions to two pilot programs of the Carrascolendas series. A total of 360 Puerto Rican-American, Cuban-American, Mexican-American, and Anglo-American children in grades 1, 2, and 3 were observed as they watched the programs. Results indicated that there was high eye contact during the…

  8. Formation of Freirian Facilitators.

    ERIC Educational Resources Information Center

    Noble, Phyllis

    This paper is written for people who are already familiar with the philosophy and methodology of Paulo Freire's liberatory education and are interested in creating a formation program for adult education facilitators using his ideas. The author describes the paper as "a collection of thoughts, of things to consider," when organizing such a…

  9. Formation in the Classroom

    ERIC Educational Resources Information Center

    Glennon, Fred; Jacobsen, Douglas; Jacobsen, Rhonda Hustedt; Thatamanil, John J.; Porterfield, Amanda; Moore, Mary Elizabeth

    2011-01-01

    What is the relationship between the academic knowledge of the guild and the formation of students in the classroom? This Forum gathers four essays originally presented at a Special Topics Session at the 2009 conference of the American Academy of Religion (Atlanta, Georgia), with a brief introductory essay by Fred Glennon explaining the genesis of…

  10. Concept Formation and Abstraction.

    ERIC Educational Resources Information Center

    Lunzer, Eric A.

    1979-01-01

    This paper examines the nature of concepts and conceptual processes and the manner of their formation. It argues that a process of successive abstraction and systematization is central to the evolution of conceptual structures. Classificatory processes are discussed and three levels of abstraction outlined. (Author/SJL)

  11. Common file formats.

    PubMed

    Leonard, Shonda A; Littlejohn, Timothy G; Baxevanis, Andreas D

    2007-01-01

    This appendix discusses a few of the file formats frequently encountered in bioinformatics. Specifically, it reviews the rules for generating FASTA files and provides guidance for interpreting NCBI descriptor lines, commonly found in FASTA files. In addition, it reviews the construction of GenBank, Phylip, MSF and Nexus files. PMID:18428774

  12. Kepler Planet Formation

    NASA Technical Reports Server (NTRS)

    Lissauer, Jack J.

    2015-01-01

    Kepler has vastly increased our knowledge of planets and planetary systems located close to stars. The new data shows surprising results for planetary abundances, planetary spacings and the distribution of planets on a mass-radius diagram. The implications of these results for theories of planet formation will be discussed.

  13. Generic file format

    NASA Astrophysics Data System (ADS)

    Felgate, Nick

    2002-11-01

    The Generic File Format (GFF) is a file format developed within the UK ASW community for the interchange and storage of underwater sonar data. Originally developed for the interchange of time-series data between analysis systems, it has been extended to provide for storage of processed acoustic data (e.g., power and DEMON spectrum, lofargram grey-scale), nonacoustic data (e.g., own-ship dynamics, sensor configuration) and event data (e.g., tracker output, sonar intercepts). The format employs the chunk concept, as used in the WAV and AIFF file formats, to provide extendability (including local variants) while providing a measure of backward compatability. However, the basic concept has been adapted to allow for the mixing in the one file of multiple channels of different sample-rates and data-types through the inclusion of a data frame concept and multiple data blocks. Chunk cross-referencing has been employed to ensure data consistency. A provision is made in the header of the file to store details of the sensor and processing for the data (e.g., the number of hydrophones, beam direction, FFT size) so that an analysis system does not need to know about the sensor or other system from which the data originated.

  14. The Formation of Trihalomethanes.

    ERIC Educational Resources Information Center

    Trussell, R. Rhodes; Umphres, Mark D.

    1978-01-01

    Reviewed are a number of factors important in the formation of trihalomethanes (THM) including the nature of aquatic humus and the influences of preozonation, bromide, pH, and chlorine. A brief investigation is also conducted into the kinetics of the THM reaction. Several major research needs are represented. (CS)

  15. Formation of anodic aluminum oxide with serrated nanochannels.

    PubMed

    Li, Dongdong; Zhao, Liang; Jiang, Chuanhai; Lu, Jia G

    2010-08-11

    We report a simple and robust method to self-assemble porous anodic aluminum oxide membranes with serrated nanochannels by anodizing in phosphoric acid solution. Due to high field conduction and anionic incorporation, an increase of anodizing voltage leads to an increase of the impurity levels and also the field strength across barrier layer. On the basis of both experiment and simulation results, the initiation and formation of serrated channels are attributed to the evolution of oxygen gas bubbles followed by plastic deformation in the oxide film. Alternating anodization in oxalic and phosphoric acids is applied to construct multilayered membranes with smooth and serrated channels, demonstrating a unique way to design and construct a three-dimensional hierarchical system with controllable morphology and composition. PMID:20617804

  16. Pattern formation today

    PubMed Central

    Chuong, Cheng-Ming; Richardson, Michael K.

    2010-01-01

    Patterns are orders embedded in randomness. They may appear as spatial arrangements or temporal series, and the elements may appear identical or with variations. Patterns exist in the physical world as well as in living systems. In the biological world, patterns can range from simple to complex, forming the basic building blocks of life. The process which generates this ordering in the biological world was termed pattern formation. Since Wolpert promoted this concept four decades ago, scientists from molecular biology, developmental biology, stem cell biology, tissue engineering, theoretical modeling and other disciplines have made remarkable progress towards understanding its mechanisms. It is time to review and re-integrate our understanding. Here, we explore the origin of pattern formation, how the genetic code is translated into biological form, and how complex phenotypes are selected over evolutionary time. We present four topics: Principles, Evolution, Development, and Stem Cells and Regeneration. We have interviewed several leaders in the field to gain insight into how their research and the field of pattern formation have shaped each other. We have learned that both molecular process and physico-chemical principles are important for biological pattern formation. New understanding will emerge through integration of the analytical approach of molecular-genetic manipulation and the systemic approach of model simulation. We regret that we could not include every major investigator in the field, but hope that this Special Issue of the Int. J. Dev. Biol. represents a sample of our knowledge of pattern formation today, which will help to stimulate more research on this fundamental process. PMID:19557673

  17. Medusae Fossae Formation

    NASA Technical Reports Server (NTRS)

    2002-01-01

    (Released 10 April 2002) The Science This THEMIS visible image was acquired near 7o S, 172o W (188o E) and shows a remarkable martian geologic deposit known as the Medusae Fossae Formation. This Formation, seen here as the raised plateau in the upper two-thirds of the image, is a soft, easily eroded deposit that extends for nearly 1,000 km along the equator of Mars. In this region the deposit has been heavily eroded by the wind to produce a series of linear ridges called yardangs. These parallel ridges point in direction of the prevailing winds that carved them, and demonstrate the power of martian winds to sculpt the dry landscape of Mars. The Medusae Fossae Formation has been completely stripped from the surface in the lower third of the image, revealing a harder layer below that is more resistant to wind erosion. The easily eroded nature of the Medusae Fossae Formation suggests that it is composed of weakly cemented particles, and was most likely formed by the deposition of wind-blown dust or volcanic ash. Several ancient craters that were once completely buried by this deposit are being exposed, or exhumed, as the overlying Medusae Formation is removed. Very few impact craters are visible on this Formation, indicating that the surface seen today is relatively young, and that the processes of erosion are likely to be actively occurring. The Story Medusa of Greek mythology fame, the name-giver to this region, had snaky locks of hair that could turn a person to stone. Wild and unruly, this monster of the underworld could certainly wreak havoc on the world of the human imagination. As scary as she was, Medusa would have no advantage over the fierce, masterful winds blowing across Mars, which once carved the streaky, terrain at the top of this image. Wild and whipping, these winds have slowly eroded away the 'topsoil,' revealing ancient craters and other surface features they once covered. The loosely cemented particles of this 'topsoil' are likely made up of dust

  18. Studies of ${\\rm Nb}_{3}{\\rm Sn}$ Strands Based on the Restacked-Rod Process for High Field Accelerator Magnets

    SciTech Connect

    Barzi, E.; Bossert, M.; Gallo, G.; Lombardo, V.; Turrioni, D.; Yamada, R.; Zlobin, A. V.

    2011-12-21

    A major thrust in Fermilab's accelerator magnet R&D program is the development of Nb3Sn wires which meet target requirements for high field magnets, such as high critical current density, low effective filament size, and the capability to withstand the cabling process. The performance of a number of strands with 150/169 restack design produced by Oxford Superconducting Technology was studied for round and deformed wires. To optimize the maximum plastic strain, finite element modeling was also used as an aid in the design. Results of mechanical, transport and metallographic analyses are presented for round and deformed wires.

  19. Cosmological structure formation

    NASA Technical Reports Server (NTRS)

    Schramm, David N.

    1991-01-01

    A summary of the current forefront problem of physical cosmology, the formation of structures (galaxies, clusters, great walls, etc.) in the universe is presented. Solutions require two key ingredients: (1) matter; and (2) seeds. Regarding the matter, it now seems clear that both baryonic and non-baryonic matter are required. Whether the non-baryonic matter is hot or cold depends on the choice of seeds. Regarding the seeds, both density fluctuations and topological defects are discussed. The combination of isotropy of the microwave background and the recent observations indicating more power on large scales have severly constrained, if not eliminated, Gaussian fluctuations with equal power on all scales, regardless of the eventual resolution of both the matter and seed questions. It is important to note that all current structure formation ideas require new physics beyond SU(3) x SU(2) x U(1).

  20. Emptiness Formation Probability

    NASA Astrophysics Data System (ADS)

    Crawford, Nicholas; Ng, Stephen; Starr, Shannon

    2016-08-01

    We present rigorous upper and lower bounds on the emptiness formation probability for the ground state of a spin-1/2 Heisenberg XXZ quantum spin system. For a d-dimensional system we find a rate of decay of the order {exp(-c L^{d+1})} where L is the sidelength of the box in which we ask for the emptiness formation event to occur. In the {d=1} case this confirms previous predictions made in the integrable systems community, though our bounds do not achieve the precision predicted by Bethe ansatz calculations. On the other hand, our bounds in the case {d ≥ 2} are new. The main tools we use are reflection positivity and a rigorous path integral expansion, which is a variation on those previously introduced by Toth, Aizenman-Nachtergaele and Ueltschi.

  1. Tetrahedron Formation Control

    NASA Technical Reports Server (NTRS)

    Petruzzo, Charles; Guzman, Jose

    2004-01-01

    This paper considers the preliminary development of a general optimization procedure for tetrahedron formation control. The maneuvers are assumed to be impulsive and a multi-stage optimization method is employed. The stages include (1) targeting to a fixed tetrahedron location and orientation, and (2) rotating and translating the tetrahedron. The number of impulsive maneuvers can also be varied. As the impulse locations and times change, new arcs are computed using a differential corrections scheme that varies the impulse magnitudes and directions. The result is a continuous trajectory with velocity discontinuities. The velocity discontinuities are then used to formulate the cost function. Direct optimization techniques are employed. The procedure is applied to the NASA Goddard Magnetospheric Multi-Scale (MMS) mission to compute preliminary formation control fuel requirements.

  2. Prominence Formation Processes

    NASA Astrophysics Data System (ADS)

    Welsch, B. T.; DeVore, C. R.; Antiochos, S. K.

    2005-01-01

    Martens and Zwaan (ApJ v. 558 872) have proposed a prominence/ filament formation model in which differential rotation drives reconnection between two initially unconnected active regions to form helical field lines that support mass and are held down by overlying field. Using an MHD solver with adaptive refinement we simulated this process by imposing a shear flow meant to mimic differential rotation on two bipolar flux distributions meant to mimic distinct active regions. In some runs the flux systems are initially potential while in others they have been twisted by footpoint rotation to inject helicity prior to imposing the shear flow. The resulting structures are studied to understand the role of helicity in the formation of prominence-like structures.

  3. Formation of bacterial nanocells

    NASA Astrophysics Data System (ADS)

    Vainshtein, Mikhail; Kudryashova, Ekaterina; Suzina, Natalia; Ariskina, Elena; Voronkov, Vadim

    1998-07-01

    Existence of nanobacteria received increasing attention both in environmental microbiology/geomicro-biology and in medical microbiology. In order to study a production of nanoforms by typical bacterial cells. Effects of different physical factors were investigated. Treatment of bacterial cultures with microwave radiation, or culturing in field of electric current resulted in formation a few types of nanocells. The number and type of nanoforms were determined with type and dose of the treatment. The produced nanoforms were: i) globules, ii) clusters of the globules--probably produced by liaison, iii) nanocells coated with membrane. The viability of the globules is an object opened for doubts. The nanocells discovered multiplication and growth on solidified nutrient media. The authors suggest that formation of nanocells is a common response of bacteria to stress-actions produced by different agents.

  4. Galaxy Formation and Evolution

    NASA Astrophysics Data System (ADS)

    Nagamine, Kentaro; Reddy, Naveen; Daddi, Emanuele; Sargent, Mark T.

    2016-07-01

    In this chapter, we discuss the current status of observational and computational studies on galaxy formation and evolution. In particular, a joint analysis of star-formation rates (SFRs), stellar masses, and metallicities of galaxies throughout cosmic time can shed light on the processes by which galaxies build up their stellar mass and enrich the environment with heavy elements. Comparison of such observations and the results of numerical simulations can give us insights on the physical importance of various feedback effects by supernovae and active galactic nuclei. In Sect. 1, we first discuss the primary methods used to deduce the SFRs, stellar masses, and (primarily) gas-phase metallicities in high-redshift galaxies. Then, we show how these quantities are related to each other and evolve with time. In Sect. 2, we further examine the distribution of SFRs in galaxies following the `Main Sequence' paradigm. We show how the so-called `starbursts' display higher specific SFRs and SF efficiencies by an order of magnitude. We use this to devise a simple description of the evolution of the star-forming galaxy population since z ˜3 that can successfully reproduce some of the observed statistics in the infrared (IR) wavelength. We also discuss the properties of molecular gas. In Sect. 3, we highlight some of the recent studies of high-redshift galaxy formation using cosmological hydrodynamic simulations. We discuss the physical properties of simulated galaxies such as luminosity function and escape fraction of ionizing photons, which are important statistics for reionization of the Universe. In particular the escape fraction of ionizing photons has large uncertainties, and studying gamma-ray bursts (which is the main topic of this conference) can also set observational constraints on this uncertain physical parameter as well as cosmic star formation rate density.

  5. Simulations of antihydrogen formation

    SciTech Connect

    Robicheaux, F.

    2004-08-01

    The results of simulations of antihydrogen formation in a Penning trap are reported. The antihydrogen atoms are formed by three-body capture. We find that the arrested nature of the three-body capture in the trap greatly reduces the expected binding energy of the antihydrogen. Typically, the formed antihydrogen has larger velocity along the magnetic field than across the field and a binding energy below k{sub B}T.

  6. Formate-assisted pyrolysis

    DOEpatents

    DeSisto, William Joseph; Wheeler, Marshall Clayton; van Heiningen, Adriaan R. P.

    2015-03-17

    The present invention provides, among other thing, methods for creating significantly deoxygenated bio-oils form biomass including the steps of providing a feedstock, associating the feedstock with an alkali formate to form a treated feedstock, dewatering the treated feedstock, heating the dewatered treated feedstock to form a vapor product, and condensing the vapor product to form a pyrolysis oil, wherein the pyrolysis oil contains less than 30% oxygen by weight.

  7. Mesospheric cloud formations

    NASA Technical Reports Server (NTRS)

    Forbes, J. M.

    1980-01-01

    Formation of mesospheric clouds as a result of deposition of large amounts of H2O by the heavy lift launch vehicle (HLLV) of the solar power satellite system is discussed. The conditions which must be met in order to form and maintain clouds near the mesopause are described. The frequency and magnitude of H2O injections from the HLLV rocket exhaust are considered.

  8. Hail Formation in Florida

    NASA Astrophysics Data System (ADS)

    Stanley, Matthew

    Hail poses a substantial threat to life and property in the state of Florida. These losses could be minimized through better understanding of the relationships between atmospheric variables that impact hail formation in Florida. Improving hail forecasting in Florida requires analyzing a number of meteorological parameters and synoptic data related to hail formation. NOAA archive data was retrieved to create a database that was used to categorize text files of hail days. The text files were entered into the National Oceanic and Atmospheric Administration Earth System Research Laboratory website to create National Centers for Environmental Prediction/National Center for Atmospheric Research Reanalysis maps of atmospheric variables for Florida hail days as well as days leading to the hail event. These data were then analyzed to determine the relationship between variables that affect hail formation, in general, across different regions and seasons in Florida using Statistical Product and Service Solutions. The reasoning for the differing factors affecting hail formation between regions, seasons and hail sizes were discussed, as well as forecasting suggestions relating to region and month in Florida. The study found that the majority of all hail that occurs in Florida is during the wet season. A low Lifted Index, high Precipitable Water and lower than average Sea Level Pressure, in most cases, is present during hail days in Florida. Furthermore, results show that Vector Wind magnitude increases as hail size increases. Additionally, several atmospheric variables useful to studying hail events, such as Lifted Index, Precipitable Water, Sea Level Pressure, Vector Wind and Temperature have significant correlations with each other depending on the region and season being observed. Strong correlations between low Lifted Index, high Precipitable Water values and the occurrence of hail events are discussed, as well as the relationship between temperature anomalies at various

  9. Tetrahedron Formation Control

    NASA Technical Reports Server (NTRS)

    Guzman, Jose J.

    2003-01-01

    Spacecraft flying in tetrahedron formations are excellent instrument platforms for electromagnetic and plasma studies. A minimum of four spacecraft - to establish a volume - is required to study some of the key regions of a planetary magnetic field. The usefulness of the measurements recorded is strongly affected by the tetrahedron orbital evolution. This paper considers the preliminary development of a general optimization procedure for tetrahedron formation control. The maneuvers are assumed to be impulsive and a multi-stage optimization method is employed. The stages include targeting to a fixed tetrahedron orientation, rotating and translating the tetrahedron and/or varying the initial and final times. The number of impulsive maneuvers citn also be varied. As the impulse locations and times change, new arcs are computed using a differential corrections scheme that varies the impulse magnitudes and directions. The result is a continuous trajectory with velocity discontinuities. The velocity discontinuities are then used to formulate the cost function. Direct optimization techniques are employed. The procedure is applied to the Magnetospheric Multiscale Mission (MMS) to compute preliminary formation control fuel requirements.

  10. Terrestrial planet formation.

    PubMed

    Righter, K; O'Brien, D P

    2011-11-29

    Advances in our understanding of terrestrial planet formation have come from a multidisciplinary approach. Studies of the ages and compositions of primitive meteorites with compositions similar to the Sun have helped to constrain the nature of the building blocks of planets. This information helps to guide numerical models for the three stages of planet formation from dust to planetesimals (~10(6) y), followed by planetesimals to embryos (lunar to Mars-sized objects; few 10(6) y), and finally embryos to planets (10(7)-10(8) y). Defining the role of turbulence in the early nebula is a key to understanding the growth of solids larger than meter size. The initiation of runaway growth of embryos from planetesimals ultimately leads to the growth of large terrestrial planets via large impacts. Dynamical models can produce inner Solar System configurations that closely resemble our Solar System, especially when the orbital effects of large planets (Jupiter and Saturn) and damping mechanisms, such as gas drag, are included. Experimental studies of terrestrial planet interiors provide additional constraints on the conditions of differentiation and, therefore, origin. A more complete understanding of terrestrial planet formation might be possible via a combination of chemical and physical modeling, as well as obtaining samples and new geophysical data from other planets (Venus, Mars, or Mercury) and asteroids.

  11. Terrestrial planet formation.

    PubMed

    Righter, K; O'Brien, D P

    2011-11-29

    Advances in our understanding of terrestrial planet formation have come from a multidisciplinary approach. Studies of the ages and compositions of primitive meteorites with compositions similar to the Sun have helped to constrain the nature of the building blocks of planets. This information helps to guide numerical models for the three stages of planet formation from dust to planetesimals (~10(6) y), followed by planetesimals to embryos (lunar to Mars-sized objects; few 10(6) y), and finally embryos to planets (10(7)-10(8) y). Defining the role of turbulence in the early nebula is a key to understanding the growth of solids larger than meter size. The initiation of runaway growth of embryos from planetesimals ultimately leads to the growth of large terrestrial planets via large impacts. Dynamical models can produce inner Solar System configurations that closely resemble our Solar System, especially when the orbital effects of large planets (Jupiter and Saturn) and damping mechanisms, such as gas drag, are included. Experimental studies of terrestrial planet interiors provide additional constraints on the conditions of differentiation and, therefore, origin. A more complete understanding of terrestrial planet formation might be possible via a combination of chemical and physical modeling, as well as obtaining samples and new geophysical data from other planets (Venus, Mars, or Mercury) and asteroids. PMID:21709256

  12. Mars brine formation experiment

    NASA Astrophysics Data System (ADS)

    Moore, Jeffrey M.; Bullock, Mark A.; Stoker, Carol R.

    1993-09-01

    Evaporites, particularly carbonates, nitrates, and sulfates, may be major sinks of volatiles scavenged from the martian atmosphere. Mars is thought to have once had a denser, warmer atmosphere that permitted the presence of liquid surface water. The conversion of atmospheric CO2 into carbonate is hypothesized to have degraded the martian climate to its present state of a generally subfreezing, desiccated desert. The rate for such a conversion under martian conditions is poorly known, so the time scale of climate degradation by this process cannot be easily evaluated. If some models are correct, carbonate formation may have been fast at geological time scales. The experiments of Booth and Kieffer also imply fast (106 - 107 yr) removal of the missing CO2 inventory, estimated to be 1 - 5 bar, by means of carbonate formation. The timing of formation of many of the fluvial features observed on Mars is, in large part, dependent on when and how fast the atmosphere changed. A knowledge of the rate at which carbonates and nitrates formed is also essential for assessing the probability that life, or its chemical precursors, could have developed on Mars. No previous experiments have quantitatively evaluated the rate of solution for a suite of mobile anions and cations from unaltered minerals and atmospheric gases into liquid water under Mars-like conditions. Such experiments are the focus of this task.

  13. Terrestrial planet formation

    PubMed Central

    Righter, K.; O’Brien, D. P.

    2011-01-01

    Advances in our understanding of terrestrial planet formation have come from a multidisciplinary approach. Studies of the ages and compositions of primitive meteorites with compositions similar to the Sun have helped to constrain the nature of the building blocks of planets. This information helps to guide numerical models for the three stages of planet formation from dust to planetesimals (∼106 y), followed by planetesimals to embryos (lunar to Mars-sized objects; few × 106 y), and finally embryos to planets (107–108 y). Defining the role of turbulence in the early nebula is a key to understanding the growth of solids larger than meter size. The initiation of runaway growth of embryos from planetesimals ultimately leads to the growth of large terrestrial planets via large impacts. Dynamical models can produce inner Solar System configurations that closely resemble our Solar System, especially when the orbital effects of large planets (Jupiter and Saturn) and damping mechanisms, such as gas drag, are included. Experimental studies of terrestrial planet interiors provide additional constraints on the conditions of differentiation and, therefore, origin. A more complete understanding of terrestrial planet formation might be possible via a combination of chemical and physical modeling, as well as obtaining samples and new geophysical data from other planets (Venus, Mars, or Mercury) and asteroids. PMID:21709256

  14. Model of kimberlite formation

    NASA Astrophysics Data System (ADS)

    Kostrovitsky, Sergey; Fiveyskaya, Lyudmila

    2013-04-01

    The critical goals in recognizing the nature of kimberlites are to find out: (1) the primary composition of melt of these rocks and (2) the principal processes of evolution of primary composition of kimberlites while ascending from mantle depth towards earth surface. Suppose, that the primary composition of kimberlite melt-fluid was in fact the composition of asthenosphere melt geochemically being close to alkaline-basalt (Hi-µ) saturated with high CO2. The genetic relation of kimberlites with basaltoids is indicated by a spatial and temporal affinity of their formation (Carlson et al, 2006; Lehmann et al, 2010; Tappe et al, 2012), similarity of the pattern of incompatible elements distribution, presence of megacryst minerals in alkaline basaltoids, Pyr-Alm garnet included, and finally, model calculation of parent melt composition for low-Cr megacryst minerals; it showed this composition to be typical for the alkaline basaltoid (Jones, 1980). At the asthenosphere level there was differentiation of basaltoid melt-fluid which was responsible for formation of its different parts with varying melt to fluid ratio and possibly varying content of alkalis (K2O). The outbreak of asthenosphere substance through lithosphere mantle proceeded by different scenarios: (a) With a noticeable dominance of fluid component kimberlites were formed by the capture and contamination of high-Mg, high-Cr rocks of lithosphere mantle that caused formation of high-Mg kimberlites. That corresponds to model of Russell (2012). (b) With a considerable proportion of melt phase depending on saturation in fluid there formed magnesium-ferriferous and ferriferous-titaniferous petrochemical types of kimberlites. There is no doubt that in formation of these kimberlite types the contamination of lithosphere material was the case, at the much lower level than in formation of high-Mg kimberlites. This model logically explains steady differences of petrochemistry of kimberlites making up clusters of

  15. Formation of giant planets

    NASA Astrophysics Data System (ADS)

    Magni, G.; Coradini, A.

    2003-04-01

    In this presentation we address the problem of the formation of giant planets and their regular satellites. We study in particular the problem of formation of the Jupiter System comparing the results of the model with the present characteristics of the system, in order to identify what are those better represented by our approach. In fact here, using a 3-D hydro-dynamical code, we study the modalities of gas accretion onto a solid core, believed to be the seed from which Jupiter started. To do that we have modelled three main regions: the central planet, a turbulent accretion disk surrounding it and an extended region from which the gas is collected. In the extended region we treat the gas as a frictionless fluid. Our main goal is to identify what are the characteristics of the planet during its growth and the physical parameters affecting its growth at the expenses of the nebular gas present in the feeding zone. Moreover we want to understand what are the thermodynamical parameters characterizing the gas captured by the planet and swirling around it. Finally, we check if a disk can be formed in prograde rotation around the planet and if this disk can survive the final phases of the planet formation. Due to the interaction between the accreting planet and the disk it has been necessary to develop a complete model of the Jupiter’s structure. In fact the radiation emitted by the growing planet heats up the surrounding gas. In turn the planet’s thermodynamic structure depend on the mass accretion rate onto it. When the accretion is rapid, shock waves in the gas are formed close to the planet. This region cannot be safely treated by a numerical code; for this reason we have developed a semi-analytically model of a a turbulent accretion disk to be considered as transition between the planet and the surrounding disk.

  16. What initiated planetesimal formation?

    NASA Technical Reports Server (NTRS)

    Cuzzi, J. N.; Dobrovolskis, A. R.; Hogan, R. C.

    1994-01-01

    The physical structure of primitive (chondritic) meteorites, even after some geological processing and modification, is thought by most to contain clues as to the first stage of accretion of solid matter into objects that might be called planetesimals. However, theoretical understanding of the processes responsible for this important stage is shaky. We note what we believe are fundamental obstacles for the Goldreich-Ward version of rapid and direct planetesimal formation via gravitational instability in a settled particle layer, and describe an alternative scenario which might lead from grainy nebula gas to primitive planetesimals in a way that has intriguing connections to the meteorite evidence.

  17. Modeling river delta formation.

    PubMed

    Seybold, Hansjörg; Andrade, José S; Herrmann, Hans J

    2007-10-23

    A model to simulate the time evolution of river delta formation process is presented. It is based on the continuity equation for water and sediment flow and a phenomenological sedimentation/erosion law. Different delta types are reproduced by using different parameters and erosion rules. The structures of the calculated patterns are analyzed in space and time and compared with real data patterns. Furthermore, our model is capable of simulating the rich dynamics related to the switching of the mouth of the river delta. The simulation results are then compared with geological records for the Mississippi River. PMID:17940031

  18. Ultrarelativistic black hole formation.

    PubMed

    East, William E; Pretorius, Frans

    2013-03-01

    We study the head-on collision of fluid particles well within the kinetic energy dominated regime (γ = 8 to 12) by numerically solving the Einstein-hydrodynamic equations. We find that the threshold for black hole formation is lower (by a factor of a few) than simple hoop conjecture estimates, and, moreover, near this threshold two distinct apparent horizons first form postcollision and then merge. We argue that this can be understood in terms of a gravitational focusing effect. The gravitational radiation reaches luminosities of 0.014 c(5)/G, carrying 16 ± 2% of the total energy.

  19. Adiabatic Halo Formation

    SciTech Connect

    Bazzani, A.; Turchetti, G.; Benedetti, C.; Rambaldi, S.; Servizi, G.

    2005-06-08

    In a high intensity circular accelerator the synchrotron dynamics introduces a slow modulation in the betatronic tune due to the space-charge tune depression. When the transverse motion is non-linear due to the presence of multipolar effects, resonance islands move in the phase space and change their amplitude. This effect introduces the trapping and detrapping phenomenon and a slow diffusion in the phase space. We apply the neo-adiabatic theory to describe this diffusion mechanism that can contribute to halo formation.

  20. Flexible formation configuration for terrain following flight: Formation keeping constraints

    NASA Astrophysics Data System (ADS)

    Latyshev, Simon

    This work suggests a control method for the terrain-following formation motion of a group of communicating autonomous agents. The presented approach centers on defining a suitable set of constraints for formation keeping task that shall be fulfilled while agents are negotiating an unknown terrain toward the predefined goal location. It allows agents to maintain a general geometric formation shape, while allowing each individual formation member freedom of maneuver, required for terrain collision free motion. Formation structure is defined with the use of virtual leader. Formation keeping constraints are defined with plane surfaces, specified relative to position and navigation vector of the virtual leader. Formation navigation and guidance constraints are defined using navigation vectors of formation members and the virtual leader. Alternative designs for the constraints derived with parabolic, cone, and cylindrical surfaces are considered. Formation control is derived using the Udwadia-Kalaba equation, following corresponding approach to the development of control methods for constraint based dynamical systems, including leader-follower systems defined using geometric constraints. Approach to terrain following motion requiring agents to stay within bounds of cylindrical corridor volumes built around their respective navigation vectors is assumed. Individual formation primitives and multi-level, hierarchical, formation structures are considered. Simulations, based on three degrees of freedom nonlinear model of an agent, performed using Mathematica and specifically developed combined Maya-Mathematica modeling and simulation system, demonstrate that a flexible terrain following formation motion is achieved with the presented sets of constraints.

  1. Star Formation in Irregular Galaxies.

    ERIC Educational Resources Information Center

    Hunter, Deidre; Wolff, Sidney

    1985-01-01

    Examines mechanisms of how stars are formed in irregular galaxies. Formation in giant irregular galaxies, formation in dwarf irregular galaxies, and comparisons with larger star-forming regions found in spiral galaxies are considered separately. (JN)

  2. Standard exercise report format (SERF)

    SciTech Connect

    1995-12-31

    This talk summarizes the reasons for the development of draft SERF the Standard Exercise Report Format used for reporting the results of emergency preparedness exercises, and gives a summary of the format and rational behind it.

  3. Formats for Presenting Procedural Instruction

    ERIC Educational Resources Information Center

    Blaiwes, Arthur S.

    1974-01-01

    Thirty male college students performed a mock communication controller's task under three different instructional formats, short sentences, logical tree, and coding. It was concluded that format variations mainly influence the more difficult tasks. (Author/DE)

  4. Tooth formation - delayed or absent

    MedlinePlus

    Delayed or absent tooth formation; Teeth - delayed or absent formation ... The age at which a tooth comes in varies. Most infants get their first tooth between 6 and 9 months, but it may be earlier or later. ...

  5. Fullerene formation and annealing

    SciTech Connect

    Mintmire, J.W.

    1996-04-05

    Why does the highly symmetric carbon cluster C{sub 60} form in such profusion under the right conditions? This question was first asked in 1985, when Kroto suggested that the predominance of the C{sub 60} carbon clusters observed in the molecular beam experiments could be explained by the truncated icosahedral (or soccer ball) form. The name given to this cluster, buckminsterfullerene, led to the use of the term fullerenes for the family of hollow-cage carbon clusters made up of even numbers of triply coordinated carbons arranged with 12 pentagonal rings and an almost arbitrary number of hexagonal rings. More than a decade later, we still lack a completely satisfying understanding of the fundamental chemistry that takes place during fullerene formation. Most current models for fullerene formation require a facile mechanism for ring rearrangement in the fullerene structure, but the simplest proposed mechanisms are believed to have unrealistically high activation barriers. In recent research calculations have suggested that atomic carbon in the reaction mixture could act as a catalyst and allow substantially lower activation barriers for fullerene annealing. This article discusses the background for this research and other adjunct research. 14 refs.

  6. Bubble formation in microgravity

    NASA Technical Reports Server (NTRS)

    Antar, Basil N.

    1994-01-01

    Two KC-135 flight campaigns have been conducted to date which are specifically dedicated to study bubble formation in microgravity. The first flight was conducted during March 14-18, 1994, and the other during June 20-24, 1994. The results from the June 1994 flight have not been analyzed yet, while the results from the March flight have been partially analyzed. In the first flight three different experiments were performed, one with the specific aim at determining whether or not cavitation can take place during any of the fluid handling procedures adopted in the shuttle bioprocessing experiments. The other experiments were concerned with duplicating some of the procedures that resulted in bubble formation, namely the NCS filling procedure and the needle scratch of a solid surface. The results from this set of experiments suggest that cavitation did not take place during any of the fluid handling procedures. The results clearly indicate that almost all were generated as a result of the breakup of the gas/liquid interface. This was convincingly demonstrated in the scratch tests as well as in the liquid fill tests.

  7. High-Field Superconducting Magnets Supporting PTOLEMY

    NASA Astrophysics Data System (ADS)

    Hopkins, Ann; Luo, Audrey; Osherson, Benjamin; Gentile, Charles; Tully, Chris; Cohen, Adam

    2013-10-01

    The Princeton Tritium Observatory for Light, Early Universe, Massive Neutrino Yield (PTOLEMY) is an experiment planned to collect data on Big Bang relic neutrinos, which are predicted to be amongst the oldest and smallest particles in the universe. Currently, a proof-of-principle prototype is being developed at Princeton Plasma Physics Laboratory to test key technologies associated with the experiment. A prominent technology in the experiment is the Magnetic Adiabatic Collimation with an Electrostatic Filter (MAC-E filter), which guides tritium betas along magnetic field lines generated by superconducting magnets while deflecting those of lower energies. B field mapping is performed to ensure the magnets produce a minimum field at the midpoint of the configuration of the magnets and to verify accuracy of existing models. Preliminary tests indicate the required rapid decrease in B field strength from the bore of the more powerful 3.35 T magnet, with the field dropping to 0.18 T approximately 0.5 feet from the outermost surface of the magnet.

  8. Threats to ultra-high-field MRI

    NASA Astrophysics Data System (ADS)

    Le Bihan, Denis

    2009-08-01

    In 2004 the European Commission (EC) adopted a directive restricting occupational exposure to electromagnetic fields. This directive (2004/40/CE), which examines the possible health risks of the electromagnetic fields from mobile phones, Wi-Fi, Bluetooth and other devices, concluded that upper limits on radiation and applied electromagnetic fields are necessary to prevent workers from suffering any undue acute health effects. But although not initially intended, the biggest impact of the directive could be on magnetic resonance imaging (MRI), which is used in hospitals worldwide to produce images of unrivalled quality of the brain and other soft tissues.

  9. A compact high field magnetic force microscope.

    PubMed

    Zhou, Haibiao; Wang, Ze; Hou, Yubin; Lu, Qingyou

    2014-12-01

    We present the design and performance of a simple and compact magnetic force microscope (MFM), whose tip-sample coarse approach is implemented by the piezoelectric tube scanner (PTS) itself. In brief, a square rod shaft is axially spring-clamped on the inner wall of a metal tube which is glued inside the free end of the PTS. The shaft can thus be driven by the PTS to realize image scan and inertial stepping coarse approach. To enhance the inertial force, each of the four outer electrodes of the PTS is driven by an independent port of the controller. The MFM scan head is so compact that it can easily fit into the 52mm low temperature bore of a 20T superconducting magnet. The performance of the MFM is demonstrated by imaging a manganite thin film at low temperature and in magnetic fields up to 15T. PMID:25189114

  10. High-field superconducting nested coil magnet

    NASA Technical Reports Server (NTRS)

    Laverick, C.; Lobell, G. M.

    1970-01-01

    Superconducting magnet, employed in conjunction with five types of superconducting cables in a nested solenoid configuration, produces total, central magnetic field strengths approaching 70 kG. The multiple coils permit maximum information on cable characteristics to be gathered from one test.

  11. High Field Pulse Magnets with New Materials

    NASA Astrophysics Data System (ADS)

    Li, L.; Lesch, B.; Cochran, V. G.; Eyssa, Y.; Tozer, S.; Mielke, C. H.; Rickel, D.; van Sciver, S. W.; Schneider-Muntau, H. J.

    2004-11-01

    High performance pulse magnets using the combination of CuNb conductor and Zylon fiber composite reinforcement with bore sizes of 24, 15 and 10 mm have been designed, manufactured and tested to destruction. The magnets successfully reached the peak fields of 64, 70 and 77.8 T respectively with no destruction. Failures occurred near the end flanges at the layer. The magnet design, manufacturing and testing, and the mode of the failure are described and analyzed.

  12. A high-field superferric NMR magnet.

    PubMed

    Huson, F R; Bryan, R N; MacKay, W W; Herrick, R C; Colvin, J; Ford, J J; Pissanetzky, S; Plishker, G A; Rocha, R; Schmidt, W

    1993-01-01

    Strong, extensive magnetic fringe fields are a significant problem with magnetic resonance imaging magnets. This is particularly acute with 4-T, whole-body research magnets. To date this problem has been addressed by restricting an extensive zone around the unshielded magnet or by placing external unsaturated iron shielding around the magnet. This paper describes a solution to this problem which uses superconducting coils closely integrated with fully saturated iron elements. A 4-T, 30-cm-bore prototype, based on this design principle, was built and tested. The 5 G fringe field is contained within 1 meter of the magnet bore along the z axis. Homogeneity of the raw magnetic field is 10 ppm over 30% of the magnet's diameter after passive shimming. Compared with an unshielded magnet, 20% less superconductor is required to generate the magnetic field. Images and spectra are presented to demonstrate the magnet's viability for magnetic resonance imaging and spectroscopy.

  13. Method for measuring pollutant formation

    NASA Technical Reports Server (NTRS)

    Annen, Kurt (Inventor); Stickler, David B. (Inventor)

    2001-01-01

    Diagnostic methods for determining an instantaneous rate of pollutant formation in a combustion system are based on measurement of chemiluminescence intensity generated simultaneously with the formation of the pollutant. The chemiluminescent signal is generated by an analog reaction which occurs in parallel with a key step in the formation of a specific pollutant of interest. The connection between the analog reaction and the pollution reaction is such that the chemiluminescent signal indicates the local, instantaneous formation rate of the pollutant of interest.

  14. Formative Assessment: Simply, No Additives

    ERIC Educational Resources Information Center

    Roskos, Kathleen; Neuman, Susan B.

    2012-01-01

    Among the types of assessment the closest to daily reading instruction is formative assessment. In contrast to summative assessment, which occurs after instruction, formative assessment involves forming judgments frequently in the flow of instruction. Key features of formative assessment include identifying gaps between where students are and…

  15. Statins and bone formation.

    PubMed

    Garrett, I R; Gutierrez, G; Mundy, G R

    2001-05-01

    The main therapy needed most in the bone field is an anabolic agent for the treatment of osteoporosis. Current drugs on the market, which included bisphosphonates, calcitonin, estrogen and related compounds, vitamin D analogues trabecular microarchitecture. Therefore, it would be desirable to have a satisfactory and universally and iprifalvone, are essentially bone resorption inhibitors that mainly act to stabilize bone mass. Patients with established osteoporosis have lost more than 50% of their bone mass at critical sites in the skeleton, and more over have marked disruption of acceptable drug that would stimulate new bone formation and correct this disturbance of trabecular microarchitecture characteristic of established osteoporosis. Recently inhibitors of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, which controls the first step in the biosynthesis of cholesterol, have been shown to stimulate bone formation in rodents both in vitro and in vivo. The effect is associated with an increased expression of the bone morphogenetic protein-2 (BMP-2) gene in bone cells. These statins drugs are widely used agents for lowering cholesterol and reducing heart attacks, however they are also known to elicit numerous pleiotropic effects including inhibition of proliferation and migration of smooth muscle cells, inhibition of tumor growth and anti-inflammatory activity. Some of these effects have been attributed to not only to the reduction of cholesterol synthesis by inhibition of the HMG-CoA reductase enzyme but also by the concurrent reduction in downstream metabolites of the mevalonate pathway such as mevalonate, farnesyl pyrophosphate and geranylgeranyl pyrophosphate. The findings that statins are capable of increasing bone formation and bone mass in rodents suggests a potential new action for the statins, which may be beneficial in patients with established osteoporosis where marked bone loss has occurred. Recent clinical data suggests that they

  16. Physics of amniote formation.

    PubMed

    Fleury, Vincent; Murukutla, Ameya Vaishnavi; Chevalier, Nicolas R; Gallois, Benjamin; Capellazzi-Resta, Marina; Picquet, Pierre; Peaucelle, Alexis

    2016-08-01

    We present a detailed study of the formation of the amniotic sac in the avian embryo, and a comparison with the crocodile amniotic sac. We show that the amniotic sac forms at a circular line of stiffness contrast, separating rings of cell domains. Cells align at this boundary, and this in turn orients and concentrates the tension forces. The tissue fold which forms the amniotic sac is locked exactly along this line due to the colocalization of the stiffness contrast and of the tensile force. In addition, the tensile force plays a regenerative role when the amniotic sac is cut. The fold forming the ventral side of the embryo displays the same characteristics. This work shows that amniote embryogenesis consists of a cascade of buckling events taking place at the boundaries between regions of differing mechanical properties. Hence, amniote embryogenesis relies on a simple and robust biomechanical scheme used repeatedly, and selected ancestrally.

  17. Physics of amniote formation.

    PubMed

    Fleury, Vincent; Murukutla, Ameya Vaishnavi; Chevalier, Nicolas R; Gallois, Benjamin; Capellazzi-Resta, Marina; Picquet, Pierre; Peaucelle, Alexis

    2016-08-01

    We present a detailed study of the formation of the amniotic sac in the avian embryo, and a comparison with the crocodile amniotic sac. We show that the amniotic sac forms at a circular line of stiffness contrast, separating rings of cell domains. Cells align at this boundary, and this in turn orients and concentrates the tension forces. The tissue fold which forms the amniotic sac is locked exactly along this line due to the colocalization of the stiffness contrast and of the tensile force. In addition, the tensile force plays a regenerative role when the amniotic sac is cut. The fold forming the ventral side of the embryo displays the same characteristics. This work shows that amniote embryogenesis consists of a cascade of buckling events taking place at the boundaries between regions of differing mechanical properties. Hence, amniote embryogenesis relies on a simple and robust biomechanical scheme used repeatedly, and selected ancestrally. PMID:27627351

  18. Mechanism of GEMS formation

    SciTech Connect

    Bradley, J P; Dai, Z R

    2004-03-10

    GEMS (glass with embedded metal and sulfides) in interplanetary dust particles (IDPs) were examined using 200 keV analytical transmission electron microscopy. The morphologies and crystallography of embedded relict grains reveal that GEMS are pseudomorphs formed by irradiation processing of crystals free-floating in space. Some GEMS retain a compositional and morphological ''memory'' of the crystal from which they formed. Pseudomorphism rules out condensation, annealing, flash heating, or shock melting as alternative mechanisms of GEMS formation. A significant and often dominant fraction of the atoms in GEMS were sputtered deposited from other grains. Therefore, a normal (solar) isotopic composition is not a reliable indicator of whether GEMS formed in the solar system or in presolar interstellar or circumstellar environments.

  19. Transitions in biofilm formation

    NASA Astrophysics Data System (ADS)

    Gordon, Vernita; Thatcher, Travis; Cooley, Benjamin

    2011-03-01

    Biofilms are multicellular, dynamic communities formed by interacting unicellular organisms bound to a surface. Forming a biofilm is a developmental process, characterized by sequential changes in gene expression and behavior as bacteria and yeast progress from discrete, free-swimming cells though stages that arrive at a mature biofilm. We are developing automated metrics to identify key transitions in early biofilm formation as cells attach to a surface, populate that surface, and adhere to each other to form early microcolonies. Our metrics use high-throughput tracking and analysis of microscopy movies to localize these transitions in space and time. Each of these transitions is associated with a loss of entropy in the bacterial system and, therefore, with biological activity that drives this loss of entropy. Better understanding of these transitions will allow automated determination of the strength and turn-on of attractive cell-surface and cell-cell interactions as biofilm development progresses.

  20. DUST FORMATION IN MACRONOVAE

    SciTech Connect

    Takami, Hajime; Ioka, Kunihito; Nozawa, Takaya E-mail: kunihito.ioka@kek.jp

    2014-07-01

    We examine dust formation in macronovae (as known as kilonovae), which are the bright ejecta of neutron star binary mergers and one of the leading sites of r-process nucleosynthesis. In light of information about the first macronova candidate associated with GRB 130603B, we find that dust grains of r-process elements have difficulty forming because of the low number density of the r-process atoms, while carbon or elements lighter than iron can condense into dust if they are abundant. Dust grains absorb emission from ejecta with an opacity even greater than that of the r-process elements, and re-emit photons at infrared wavelengths. Such dust emission can potentially account for macronovae without r-process nucleosynthesis as an alternative model. This dust scenario predicts a spectrum with fewer features than the r-process model and day-scale optical-to-ultraviolet emission.

  1. Group Formation in Economics

    NASA Astrophysics Data System (ADS)

    Demange, Gabrielle; Wooders, Myrna

    2005-01-01

    Broad and diverse ranges of activities are conducted within and by organized groups of individuals, including political, economic and social activities. These activities have recently become a subject of intense interest in economics and game theory. Some of the topics investigated in this collection are models of networks of power and privilege, trade networks, co-authorship networks, buyer-seller networks with differentiated products, and networks of medical innovation and the adaptation of new information. Other topics are social norms on punctuality, clubs and the provision of club goods and public goods, research and development and collusive alliances among corporations, and international alliances and trading agreements. While relatively recent, the literature on game theoretic studies of group formation in economics is already vast. This volume provides an introduction to this important literature on game-theoretic treatments of situations with networks, clubs, and coalitions, including some applications.

  2. Physics of amniote formation

    NASA Astrophysics Data System (ADS)

    Fleury, Vincent; Murukutla, Ameya Vaishnavi; Chevalier, Nicolas R.; Gallois, Benjamin; Capellazzi-Resta, Marina; Picquet, Pierre; Peaucelle, Alexis

    2016-08-01

    We present a detailed study of the formation of the amniotic sac in the avian embryo, and a comparison with the crocodile amniotic sac. We show that the amniotic sac forms at a circular line of stiffness contrast, separating rings of cell domains. Cells align at this boundary, and this in turn orients and concentrates the tension forces. The tissue fold which forms the amniotic sac is locked exactly along this line due to the colocalization of the stiffness contrast and of the tensile force. In addition, the tensile force plays a regenerative role when the amniotic sac is cut. The fold forming the ventral side of the embryo displays the same characteristics. This work shows that amniote embryogenesis consists of a cascade of buckling events taking place at the boundaries between regions of differing mechanical properties. Hence, amniote embryogenesis relies on a simple and robust biomechanical scheme used repeatedly, and selected ancestrally.

  3. Biofilm formation by enterococci.

    PubMed

    Mohamed, Jamal A; Huang, David B

    2007-12-01

    Enterococci are an important global cause of nosocomial infections, being increasingly associated with urinary tract infections, endocarditis, intra-abdominal and pelvic infections, catheter-related infections, surgical wound infections, and central nervous system infections. The two most common enterococci species are Enterococcus faecalis and Enterococcus faecium. Both are capable of producing biofilms, which consist of a population of cells attached irreversibly on various biotic and abiotic surfaces, encased in a hydrated matrix of exopolymeric substances. Many environmental and genetic factors are associated or have been proposed to be associated with the production of biofilm. This review discusses recent advances in knowledge about the biology and genetics of biofilm formation and the role of biofilms in enterococci pathogenesis.

  4. Recipes for planet formation

    NASA Astrophysics Data System (ADS)

    Meyer, Michael R.

    2009-11-01

    Anyone who has ever used baking soda instead of baking powder when trying to make a cake knows a simple truth: ingredients matter. The same is true for planet formation. Planets are made from the materials that coalesce in a rotating disk around young stars - essentially the "leftovers" from when the stars themselves formed through the gravitational collapse of rotating clouds of gas and dust. The planet-making disk should therefore initially have the same gas-to-dust ratio as the interstellar medium: about 100 to 1, by mass. Similarly, it seems logical that the elemental composition of the disk should match that of the star, reflecting the initial conditions at that particular spot in the galaxy.

  5. High-field critical current enhancement by irradiation induced correlated and random defects in (Ba{sub 0.6}K{sub 0.4})Fe{sub 2}As{sub 2}

    SciTech Connect

    Kihlstrom, K. J.; Crabtree, G. W.; Fang, L.; Jia, Y.; Shen, B.; Koshelev, A. E.; Welp, U.; Kwok, W.-K.; Kayani, A.; Zhu, S. F.; Wen, H.-H.

    2013-11-11

    Mixed pinning landscapes in superconductors are emerging as an effective strategy to achieve high critical currents in high, applied magnetic fields. Here, we use heavy-ion and proton irradiation to create correlated and point defects to explore the vortex pinning behavior of each and combined constituent defects in the iron-based superconductor Ba{sub 0.6}K{sub 0.4}Fe{sub 2}As{sub 2} and find that the pinning mechanisms are non-additive. The major effect of p-irradiation in mixed pinning landscapes is the generation of field-independent critical currents in very high fields. At 7 T ‖ c and 5 K, the critical current density exceeds 5 MA/cm{sup 2}.

  6. High field magnetotransport and point contact Andreev reflection measurements on CuCr{sub 2}Se{sub 4} and CuCr{sub 2}Se{sub 3}Br—Degenerate magnetic semiconductor single crystals

    SciTech Connect

    Borisov, K. Coey, J. M. D.; Stamenov, P.; Alaria, J.

    2014-05-07

    Single crystals of the metallically degenerate fully magnetic semiconductors CuCr{sub 2}Se{sub 4} and CuCr{sub 2}Se{sub 3}Br have been prepared by the Chemical Vapour Transport method, using either Se or Br as transport agents. The high-quality, millimetre-sized, octahedrally faceted, needle- and platelet-shaped crystals are characterised by means of high field magnetotransport (μ{sub 0}H≤ 14 T) and Point Contact Andreev Reflection. The relatively high spin polarisation observed |P|>0.56, together with the relatively low minority carrier effective mass of 0.25 m{sub e}, and long scattering time  10{sup −13} s, could poise these materials for integration in low- and close-to-room temperature minority injection bipolar heterojunction transistor demonstrations.

  7. Medusae Fossae Formation

    NASA Technical Reports Server (NTRS)

    2002-01-01

    (Released 16 April 2002) The Science This THEMIS visible image was acquired near 11o N, 159o W (201o E) and shows examples of the remarkable variations that can be seen in the erosion of the Medusae Fossae Formation. This Formation is a soft, easily eroded deposit that extends for nearly 1,000 km along the equator of Mars. In this region, like many others throughout the Medusae Fossae Formation, the surface has been eroded by the wind into a series of linear ridges called yardangs. These ridges generally point in direction of the prevailing winds that carved them, and demonstrate the power of martian winds to erode the landscape of Mars. The easily eroded nature of the Medusae Fossae Formation suggests that it is composed of weakly cemented particles, and was most likely formed by the deposition of wind-blown dust or volcanic ash. Within this single image it is possible to see differing amounts of erosion and stripping of layers in the Medusae Fossae Formation. Near the bottom (southern) edge of the image a rock layer with a relatively smooth upper surface covers much of the image. Moving upwards (north) in the image this layer becomes more and more eroded. At first there are isolated regions where the smooth unit has been eroded to produce sets of parallel ridges and knobs. Further north these linear knobs increase in number, and only small, isolated patches of the smooth upper surface remain. Finally, at the top of the image, even the ridges have been removed, exposing the remarkably smooth top of hard, resistant layer below. This sequence of layers with differing hardness and resistance to erosion is common on Earth and on Mars, and suggests significant variations in the physical properties, composition, particle size, and/or cementation of these martian layers. As is common throughout the Medusae Fossae Formation, very few impact craters are visible, indicating that the surface exposed is relatively young, and that the process of erosion may be active today

  8. Medusae Fossae Formation

    NASA Technical Reports Server (NTRS)

    2002-01-01

    (Released 16 April 2002) The Science This THEMIS visible image was acquired near 11o N, 159o W (201o E) and shows examples of the remarkable variations that can be seen in the erosion of the Medusae Fossae Formation. This Formation is a soft, easily eroded deposit that extends for nearly 1,000 km along the equator of Mars. In this region, like many others throughout the Medusae Fossae Formation, the surface has been eroded by the wind into a series of linear ridges called yardangs. These ridges generally point in direction of the prevailing winds that carved them, and demonstrate the power of martian winds to erode the landscape of Mars. The easily eroded nature of the Medusae Fossae Formation suggests that it is composed of weakly cemented particles, and was most likely formed by the deposition of wind-blown dust or volcanic ash. Within this single image it is possible to see differing amounts of erosion and stripping of layers in the Medusae Fossae Formation. Near the bottom (southern) edge of the image a rock layer with a relatively smooth upper surface covers much of the image. Moving upwards (north) in the image this layer becomes more and more eroded. At first there are isolated regions where the smooth unit has been eroded to produce sets of parallel ridges and knobs. Further north these linear knobs increase in number, and only small, isolated patches of the smooth upper surface remain. Finally, at the top of the image, even the ridges have been removed, exposing the remarkably smooth top of hard, resistant layer below. This sequence of layers with differing hardness and resistance to erosion is common on Earth and on Mars, and suggests significant variations in the physical properties, composition, particle size, and/or cementation of these martian layers. As is common throughout the Medusae Fossae Formation, very few impact craters are visible, indicating that the surface exposed is relatively young, and that the process of erosion may be active today

  9. Automatic segmentation of cartilage in high-field magnetic resonance images of the knee joint with an improved voxel-classification-driven region-growing algorithm using vicinity-correlated subsampling.

    PubMed

    Öztürk, Ceyda Nur; Albayrak, Songül

    2016-05-01

    Anatomical structures that can deteriorate over time, such as cartilage, can be successfully delineated with voxel-classification approaches in magnetic resonance (MR) images. However, segmentation via voxel-classification is a computationally demanding process for high-field MR images with high spatial resolutions. In this study, the whole femoral, tibial, and patellar cartilage compartments in the knee joint were automatically segmented in high-field MR images obtained from Osteoarthritis Initiative using a voxel-classification-driven region-growing algorithm with sample-expand method. Computational complexity of the classification was alleviated via subsampling of the background voxels in the training MR images and selecting a small subset of significant features by taking into consideration systems with limited memory and processing power. Although subsampling of the voxels may lead to a loss of generality of the training models and a decrease in segmentation accuracies, effective subsampling strategies can overcome these problems. Therefore, different subsampling techniques, which involve uniform, Gaussian, vicinity-correlated (VC) sparse, and VC dense subsampling, were used to generate four training models. The segmentation system was experimented using 10 training and 23 testing MR images, and the effects of different training models on segmentation accuracies were investigated. Experimental results showed that the highest mean Dice similarity coefficient (DSC) values for all compartments were obtained when the training models of VC sparse subsampling technique were used. Mean DSC values optimized with this technique were 82.6%, 83.1%, and 72.6% for femoral, tibial, and patellar cartilage compartments, respectively, when mean sensitivities were 79.9%, 84.0%, and 71.5%, and mean specificities were 99.8%, 99.9%, and 99.9%.

  10. Automatic segmentation of cartilage in high-field magnetic resonance images of the knee joint with an improved voxel-classification-driven region-growing algorithm using vicinity-correlated subsampling.

    PubMed

    Öztürk, Ceyda Nur; Albayrak, Songül

    2016-05-01

    Anatomical structures that can deteriorate over time, such as cartilage, can be successfully delineated with voxel-classification approaches in magnetic resonance (MR) images. However, segmentation via voxel-classification is a computationally demanding process for high-field MR images with high spatial resolutions. In this study, the whole femoral, tibial, and patellar cartilage compartments in the knee joint were automatically segmented in high-field MR images obtained from Osteoarthritis Initiative using a voxel-classification-driven region-growing algorithm with sample-expand method. Computational complexity of the classification was alleviated via subsampling of the background voxels in the training MR images and selecting a small subset of significant features by taking into consideration systems with limited memory and processing power. Although subsampling of the voxels may lead to a loss of generality of the training models and a decrease in segmentation accuracies, effective subsampling strategies can overcome these problems. Therefore, different subsampling techniques, which involve uniform, Gaussian, vicinity-correlated (VC) sparse, and VC dense subsampling, were used to generate four training models. The segmentation system was experimented using 10 training and 23 testing MR images, and the effects of different training models on segmentation accuracies were investigated. Experimental results showed that the highest mean Dice similarity coefficient (DSC) values for all compartments were obtained when the training models of VC sparse subsampling technique were used. Mean DSC values optimized with this technique were 82.6%, 83.1%, and 72.6% for femoral, tibial, and patellar cartilage compartments, respectively, when mean sensitivities were 79.9%, 84.0%, and 71.5%, and mean specificities were 99.8%, 99.9%, and 99.9%. PMID:27017069

  11. Gas formation. Formation temperatures of thermogenic and biogenic methane.

    PubMed

    Stolper, D A; Lawson, M; Davis, C L; Ferreira, A A; Santos Neto, E V; Ellis, G S; Lewan, M D; Martini, A M; Tang, Y; Schoell, M; Sessions, A L; Eiler, J M

    2014-06-27

    Methane is an important greenhouse gas and energy resource generated dominantly by methanogens at low temperatures and through the breakdown of organic molecules at high temperatures. However, methane-formation temperatures in nature are often poorly constrained. We measured formation temperatures of thermogenic and biogenic methane using a "clumped isotope" technique. Thermogenic gases yield formation temperatures between 157° and 221°C, within the nominal gas window, and biogenic gases yield formation temperatures consistent with their comparatively lower-temperature formational environments (<50°C). In systems where gases have migrated and other proxies for gas-generation temperature yield ambiguous results, methane clumped-isotope temperatures distinguish among and allow for independent tests of possible gas-formation models. PMID:24970083

  12. Acromioclavicular joint cyst formation.

    PubMed

    Hiller, Andrew D; Miller, Joshua D; Zeller, John L

    2010-03-01

    Acromioclavicular joint (ACJ) cysts are an uncommon and unusual sequela associated with shoulder pathophysiology. The majority of literature on ACJ cysts consists of individual case reports with no definitive literature review currently available. In addition to a comprehensive literature review, four clinical cases are presented in this report. First described by Craig (1984), a total of 41 cases have been previously reported in the literature. Of these cases, five occurred with the rotator cuff musculature intact. The remaining 36 cases of ACJ cysts occurred in patients with a complete tear/avulsion of the rotator cuff. Previous attempts at compiling a complete record of all reported cases have combined several distinct conditions into a single category. This article presents two distinct etiologies for the pathogenesis of ACJ cyst formation. In the presence of an intact rotator cuff, a Type 1 cyst can form superficially and be limited to the ACJ. Following a massive or traumatic tear of the rotator cuff, mechanical instability of the humeral head can cause a deterioration of the inferior acromioclavicular capsule (cuff tear arthropathy) and an overproduction of synovial fluid. Overtime, a "geyser" of fluid can form between the glenohumeral and the ACJ, forming a Type 2 cyst. This differentiation and categorization is essential for appropriate classification and treatment.

  13. Nuclear ``pasta'' formation

    NASA Astrophysics Data System (ADS)

    Schneider, A. S.; Horowitz, C. J.; Hughto, J.; Berry, D. K.

    2013-12-01

    The formation of complex nonuniform phases of nuclear matter, known as nuclear pasta, is studied with molecular dynamics (MD) simulations containing 51200 nucleons. A phenomenological nuclear interaction is used that reproduces the saturation binding energy and density of nuclear matter. Systems are prepared at an initial density of 0.10fm-3 and then the density is decreased by expanding the simulation volume at different rates to densities of 0.01fm-3 or less. An originally uniform system of nuclear matter is observed to form spherical bubbles (“swiss cheese”), hollow tubes, flat plates (“lasagna”), thin rods (“spaghetti”) and, finally, nearly spherical nuclei with decreasing density. We explicitly observe nucleation mechanisms, with decreasing density, for these different pasta phase transitions. Topological quantities known as Minkowski functionals are obtained to characterize the pasta shapes. Different pasta shapes are observed depending on the expansion rate. This indicates nonequilibrium effects. We use this to determine the best ways to obtain lower energy states of the pasta system from MD simulations and to place constraints on the equilibration time of the system.

  14. Bubble formation in microgravity

    NASA Technical Reports Server (NTRS)

    Antar, Basil N.

    1996-01-01

    An extensive experimental program was initiated for the purpose of understanding the mechanisms leading to bubble generation during fluid handling procedures in a microgravity environment. Several key fluid handling procedures typical for PCG experiments were identified for analysis in that program. Experiments were designed to specifically understand how such procedures can lead to bubble formation. The experiments were then conducted aboard the NASA KC-135 aircraft which is capable of simulating a low gravity environment by executing a parabolic flight attitude. However, such a flight attitude can only provide a low gravity environment of approximately 10-2go for a maximum period of 30 seconds. Thus all of the tests conducted for these experiments were designed to last no longer than 20 seconds. Several experiments were designed to simulate some of the more relevant fluid handling procedures during protein crystal growth experiments. These include submerged liquid jet cavitation, filling of a cubical vessel, submerged surface scratch, attached drop growth, liquid jet impingement, and geysering experiments. To date, four separate KC-135 flight campaigns were undertaken specifically for performing these experiments. However, different experiments were performed on different flights.

  15. Formation of "bound

    NASA Astrophysics Data System (ADS)

    Nowak, K.; Kästner, M.; Miltner, A.

    2009-04-01

    During degradation of organic pollutants in soil, metabolites, microbial biomass, CO2and "bound" residues ("non-extractable" residues in soil organic matter) are formed. Enhanced transformation of these contaminants into "bound" residues has been proposed as an alternative remediation method for polluted soils. However, this kind of residues may pose a potential risk for the environment due to their chemical structure and possible remobilization under different conditions. Therefore particular attention is given actually to "bound" residues. Part of these non-extractable residues may be "biogenic," because microorganisms use the carbon from the pollutant to form their biomass components (fatty acids, amino acids, amino sugars), which subsequently may be incorporated into soil organic matter. Furthermore, the CO2 originating from mineralization of xenobiotics, can be re-assimilated by microorganisms and also incorporated into "biogenic residue". The hazard posed by "bound" residues may be overestimated because they are "biogenic" (contain microbial fatty acids and amino acids). The knowledge about the pathways of "biogenic residue" formation is necessary for a proper assessment of the fate of tested pollutants and their turnover in the soil environment. Moreover, these data are needed to establish the realistic degradation rates of the contaminants in soil. The main objectives of this study are: to quantify the extent of "biogenic residue" (fatty acids, amino acids, amino sugars) formation during the degradation of a model pollutant (2,4-dichlorophenoxyacetic acid = 2,4-D) and during CO2 assimilation by microorganisms and to evaluate which components are mainly incorporated into "bound" residues. To investigate the extent of "biogenic residue" formation in soil during the degradation of 2,4-D, experiments with either 14C-U-ring and 13C6-2,4-D or carboxyl-14C 2,4-D were performed. The incubation experiments were performed according to OECD test guideline 307, in the

  16. Prominence formation and oscillations

    NASA Astrophysics Data System (ADS)

    Chen, P. F.

    Prominences, or filaments, are a striking phenomenon in the solar atmosphere. Besides their own rich features and dynamics, they are related to many other activities, such as solar flares and coronal mass ejections (CMEs). In the past several years we have been investigating the prominence formation, oscillations, and eruptions through both data analysis and radiative hydrodynamic and magnetohydrodynamic (MHD) simulations. This paper reviews our progress on these topics, which includes: (1) With updated radiative cooling function, the coronal condensation becomes a little faster than previous work; (2) Once a seed condensation is formed, it can grow via siphon flow spontaneously even if the evaporation stops; (3) A scaling law was obtained to relate the length of the prominence thread to various parameters, indicating that higher prominences tend to have shorter threads, which is consistent with the fact that threads are long in active region prominences and short in quiescent prominences; (4) It was proposed that long-time prominence oscillations out of phase might serve as a precursor for prominence eruptions and CMEs; (5) An ensemble of oscillating prominence threads may explain the counter-streaming motion.

  17. Acromioclavicular joint cyst formation.

    PubMed

    Hiller, Andrew D; Miller, Joshua D; Zeller, John L

    2010-03-01

    Acromioclavicular joint (ACJ) cysts are an uncommon and unusual sequela associated with shoulder pathophysiology. The majority of literature on ACJ cysts consists of individual case reports with no definitive literature review currently available. In addition to a comprehensive literature review, four clinical cases are presented in this report. First described by Craig (1984), a total of 41 cases have been previously reported in the literature. Of these cases, five occurred with the rotator cuff musculature intact. The remaining 36 cases of ACJ cysts occurred in patients with a complete tear/avulsion of the rotator cuff. Previous attempts at compiling a complete record of all reported cases have combined several distinct conditions into a single category. This article presents two distinct etiologies for the pathogenesis of ACJ cyst formation. In the presence of an intact rotator cuff, a Type 1 cyst can form superficially and be limited to the ACJ. Following a massive or traumatic tear of the rotator cuff, mechanical instability of the humeral head can cause a deterioration of the inferior acromioclavicular capsule (cuff tear arthropathy) and an overproduction of synovial fluid. Overtime, a "geyser" of fluid can form between the glenohumeral and the ACJ, forming a Type 2 cyst. This differentiation and categorization is essential for appropriate classification and treatment. PMID:20069645

  18. Bead lightning formation

    SciTech Connect

    Ludwig, G.O.; Saba, M.M.F.

    2005-09-15

    Formation of beaded structures in triggered lightning discharges is considered in the framework of both magnetohydrodynamic (MHD) and hydrodynamic instabilities. It is shown that the space periodicity of the structures can be explained in terms of the kink and sausage type instabilities in a cylindrical discharge with anomalous viscosity. In particular, the fast growth rate of the hydrodynamic Rayleigh-Taylor instability, which is driven by the backflow of air into the channel of the decaying return stroke, dominates the initial evolution of perturbations during the decay of the return current. This instability is responsible for a significant enhancement of the anomalous viscosity above the classical level. Eventually, the damping introduced at the current channel edge by the high level of anomalous viscous stresses defines the final length scale of bead lightning. Later, during the continuing current stage of the lightning flash, the MHD pinch instability persists, although with a much smaller growth rate that can be enhanced in a M-component event. The combined effect of these instabilities may explain various aspects of bead lightning.

  19. The formation of dew

    NASA Astrophysics Data System (ADS)

    Beysens, D.

    Dew is the condensation into liquid droplets of water vapor on a substrate. The presence of a substrate is the origin of the peculiarities and richness of the phenomenon. We review the aspects related to heterogeneous nucleation and subsequent growth of water droplets. A key point is the drop interaction through drop fusion or coalescence, which leads to scaling in the growth and gives universality to the process. The effects of substrate heterogeneity and gravity effects are also considered. Coalescence events lead to temporal and spatio-temporal fluctuations in the substrate coverage, drop configuration, etc., which give rise to a very peculiar dynamics. When the substrate is a liquid or a liquid crystal, the drop pattern can exhibit special spatial orders, such as crystalline, hexatic phases and fractal contours. And condensation on a solid substrate near its melting point can make the drop jump. The applications of monitoring dew formation are manyfold. Examples can be found in nanoelectronics and optics (vapor deposition and thin films), medicine (sterilization process), agriculture (green houses). We here discuss in greater details the production of clean water by "atmospheric wells".

  20. Large Format Radiographic Imaging

    SciTech Connect

    J. S. Rohrer; Lacey Stewart; M. D. Wilke; N. S. King; S. A Baker; Wilfred Lewis

    1999-08-01

    Radiographic imaging continues to be a key diagnostic in many areas at Los Alamos National Laboratory (LANL). Radiographic recording systems have taken on many form, from high repetition-rate, gated systems to film recording and storage phosphors. Some systems are designed for synchronization to an accelerator while others may be single shot or may record a frame sequence in a dynamic radiography experiment. While film recording remains a reliable standby in the radiographic community, there is growing interest in investigating electronic recording for many applications. The advantages of real time access to remote data acquisition are highly attractive. Cooled CCD camera systems are capable of providing greater sensitivity with improved signal-to-noise ratio. This paper begins with a review of performance characteristics of the Bechtel Nevada large format imaging system, a gated system capable of viewing scintillators up to 300 mm in diameter. We then examine configuration alternatives in lens coupled and fiber optically coupled electro-optical recording systems. Areas of investigation include tradeoffs between fiber optic and lens coupling, methods of image magnification, and spectral matching from scintillator to CCD camera. Key performance features discussed include field of view, resolution, sensitivity, dynamic range, and system noise characteristics.

  1. Beach-cusp formation

    USGS Publications Warehouse

    Sallenger, A.H., Jr.

    1979-01-01

    Field experiments on beach-cusp formation were undertaken to document how the cuspate form develops and to test the edge-wave hypothesis on the uniform spacing of cusps. These involved observations of cusps forming from an initially plane foreshore. The cuspate form was observed to be a product of swash modification of an intertidal beach ridge as follows. A ridge, cut by a series of channels quasi-equally spaced along its length, was deposited onto the lower foreshore. The ridge migrated shoreward with flood tide, while the longshore positions of the channels remained fixed. On ebb tide, changes in swash circulation over the ridge allowed the upwash to flow shoreward through the channels and the channel mouths were eroded progressively wider until adjacent mouths met, effecting a cuspate shape. Measured spacings of cusps, ranging in size from less than 1 m to more than 12 m, agree well with computed spacings due to either zero-mode subharmonic or zero-mode synchronous edge waves. Edge-wave-induced longshore variations in run up will cause water ponded behind a ridge to converge at points of low swash and flow seaward as relatively narrow currents eroding channels spaced at one edge-wave wavelength for synchronous edge waves or one half wavelength for subharmonic edge waves. The channels are subsequently modified into cusp troughs as described above.

  2. The KEA image file format

    NASA Astrophysics Data System (ADS)

    Bunting, Peter; Gillingham, Sam

    2013-08-01

    There are a large number of image formats already in use within the remote sensing community but currently there is no format that provides the features of: compression, support for large file sizes, ground control points, raster attribute tables and inbuilt image pyramids. Therefore, a new image format, named KEA, after the New Zealand bird, has been proposed. The KEA format provides a full implementation of the GDAL data model and is implemented within a HDF5 file. A software library with a GDAL driver have been freely provided to the community allowing use through any GDAL based software. The new format has comparable performance with existing formats while producing smaller file sizes and is already within active use for a number of projects within Landcare Research, New Zealand, and the wider community.

  3. Gaining Insight into Star Formation: Resolved Star Formation Laws

    NASA Astrophysics Data System (ADS)

    Liebst, Kelley; Scowen, Paul A.

    2014-06-01

    Until recently astronomers have used star formation laws to measure the star formation rate and star formation efficiency of galaxies only on global scales because of the poor resolution of available data. What I am now capable of producing is a spatially resolved star formation law that can provide direct insight into the physical processes that govern star formation and assess the short-term nature of bursts of star formation and the longer-term nature of larger-scale events that can dictate the global distribution of stars and the ultimate fate of a galaxy as a whole. I am using exquisite narrowband optical data from a variety of sources, including the Hubble Space Telescope, and Kitt Peak National Observatory, etc., in conjunction with infrared data from the Spitzer Infrared Nearby Galaxy Survey and the Spitzer Local Volume Legacy survey, neutral gas data from The HI Nearby Galaxy Survey, and molecular gas data from the Berkeley-Illinois-Maryland Association Survey of Nearby Galaxies, to provide star formation rates and star formation efficiencies on previously inaccessible small spatial scales across a suite of galaxies that represent a range of star formation environments and scales. My sample includes 18 spiral galaxies ranging from 2.1 to 15.1 Mpc in distance and offers a large range of morphological types (i.e. a large range of star formation environments). I am using these data to test different models of star formation modes under a variety of physical conditions and relate the variations I observe to the known local physical conditions and the associated star formation histories for each locale within each galaxy.This is the heart of the matter - that the nature and evolution of the local physical environment intimately influences how stars can form, how quickly and how massive those stars are allowed to form, and as a result how they shape the local conditions for subsequent star formation. It is this tracking of the stellar ecology that is vital for

  4. BACTERIOPHAGE FORMATION WITHOUT BACTERIAL GROWTH

    PubMed Central

    Price, Winston H.

    1947-01-01

    1. Iodoacetate, fluoride, and azide have been found to prevent the formation of phage and to inhibit the synthesis of ATP by Staphylococcus muscae. It is suggested that energy-rich phosphate is needed for the synthesis of phage. 2. Gramicidin prevented the formation of phage. 3. No differences were found between normal bacteria and phage-infected bacteria in the inorganic phosphate, adenosinetriphosphate, ribonucleic acid, and desoxyribonucleic acid content of the cells. 4. The mechanism of phage formation is discussed. PMID:18896936

  5. Binary stars - Formation by fragmentation

    NASA Technical Reports Server (NTRS)

    Boss, Alan P.

    1988-01-01

    Theories of binary star formation by capture, separate nuclei, fission and fragmentation are compared, assessing the success of theoretical attempts to explain the observed properties of main-sequence binary stars. The theory of formation by fragmentation is examined, discussing the prospects for checking the theory against observations of binary premain-sequence stars. It is concluded that formation by fragmentation is successful at explaining many of the key properties of main-sequence binary stars.

  6. Exploration of spontaneous vortex formation and intermittent behavior in ECR plasmas: The HYPER-I experiments

    NASA Astrophysics Data System (ADS)

    Yoshimura, S.; Terasaka, K.; Tanaka, E.; Aramaki, M.; Okamoto, A.; Nagaoka, K.; Tanaka, M. Y.

    2015-04-01

    HYPER-I (High Density Plasma Experiment-I) is a linear device that combines a wide operation range of plasma production with flexible diagnostics. The plasmas are produced by the electron cyclotron resonance (ECR) heating with parallel injection of right-handed circularly polarized microwaves of 2.45 GHz from the high-field side. The maximum attainable electron density is more than two orders of magnitude higher than the cutoff density of ordinary waves. Spontaneous formation of a variety of large-scale flow structures, or vortices, has been observed in the HYPER-I plasmas. Flow-velocity field measurements using directional Langmuir probes (DLPs) and laser-induced fluorescence (LIF) method have clarified the physical processes behind such vortex formations. Recently, a new intermittent behavior of local electron temperature has also been observed. Statistical analysis of the floating potential changes has revealed that the phenomenon is characterized by a stationary Poisson process.

  7. Medusae Fossae Formation

    NASA Technical Reports Server (NTRS)

    1998-01-01

    An exotic terrain of wind-eroded ridges and residual smooth surfaces are seen in one of the highest resolution images ever taken of Mars from orbit. The Medusae Fossae formation is believed to be formed of the fragmental ejecta of huge explosive volcanic eruptions. When subjected to intense wind-blasting over hundreds of millions of years, this material erodes easily once the uppermost tougher crust is breached. In the Mars Orbiter Camera (MOC) image shown on the right, the crust, or cap rock, can be seen in the upper right part of the picture. The finely-spaced ridges are similar to features on Earth called yardangs, which are formed by intense winds plucking individual grains from, and by wind-driven sand blasting particles off, sedimentary deposits.

    The MOC image was taken on October 30, 1997 at 11:05 AM PST, shortly after the Mars Global Surveyor spacecraft's 31st closest approach to Mars. The image covers an area 3.6 X 21.5 km (2.2 X 13.4 miles) at 3.6 m (12 feet) per picture element--craters only 11 m (36 feet, about the size of a swimming pool) across can be seen. The context image (left; the best Viking view of the area; VO 1 387S34) has a resolution of 240 m/pixel, or 67 times lower resolution than the MOC frame.

    Malin Space Science Systems (MSSS) and the California Institute of Technology built the MOC using spare hardware from the Mars Observer mission. MSSS operates the camera from its facilities in San Diego, CA. The Jet Propulsion Laboratory's Mars Surveyor Operations Project operates the Mars Global Surveyor spacecraft with its industrial partner, Lockheed Martin Astronautics, from facilities in Pasadena, CA and Denver, CO.

  8. ANTIBODY FORMATION IN VITRO

    PubMed Central

    Fishman, M.

    1961-01-01

    Neutralizing activity against T2 bacteriophage appeared in cultures of lymph node cells from normal rats in response to their in vitro stimulation with a cell-free filtrate derived from homogenized rat macrophages which had been incubated with T2 bacteriophage. This activity was specifically directed against T2 bacteriophage. It resided in a fraction of the culture fluid which had the salting-out properties of serum globulin. Phage neutralization was inhibited by antibody specific for rat serum gamma globulin. Antibody production against T2 bacteriophage in cultures of lymph node cells from normal animals failed to occur if (a) T2 bacteriophage alone was added, (b) if the incubation period of macrophages and T2 phage was unduly shortened, (c) if the cell-free filtrate was heated at 80–100°C for 15 minutes, (d) if more than an optimal amount of T2 bacteriophage was added to the macrophages. Additional factors which prevented the formation of antibody were the heat inactivation of the lymph node cells or the addition to the culture medium of either streptomycin or ribonuclease. Finally, it was found that macrophages and lymph node cells had to be obtained from animals of one and the same species. All essential findings on the production of antibody to T2 bacteriophage in vitro could be confirmed by substitution of the chick embryo for the tissue culture medium. The results are discussed in terms of a possible mechanism of antibody production in which an RNAse-sensitive substance resulting from the interaction of macrophages and antigen is capable of stimulating antibody synthesis in lymphocytic cells. PMID:13893304

  9. Plasmapause formation at Saturn

    NASA Astrophysics Data System (ADS)

    Thomsen, M. F.; Mitchell, D. G.; Jia, X.; Jackman, C. M.; Hospodarsky, G.; Coates, A. J.

    2015-04-01

    Cassini observations during a rapid, high-latitude, dawnside pass from Saturn's lobe to inner magnetosphere on 25 June 2009 provide strong evidence for the formation of a "plasmapause" at Saturn by Vasyliunas-type nightside reconnection of previously mass-loaded flux tubes. A population of hot, tenuous plasma that lies between the lobe and the dense inner magnetospheric plasma is consistent with a region formed by very recent injection from a reconnection region in the tail, including low density, high temperature, supercorotational flow, a significant O+ content, and the near-simultaneous observation of enhanced Saturn kilometric radiation emissions. The sharp boundary between that region and the cool dense inner magnetospheric plasma thus separates flux tubes that were involved in the reconnection from those that successfully traversed the nightside without mass loss. This event demonstrates that tail reconnection can strip off inner magnetospheric plasma in to at least dipole L = 8.6. Clear evidence of flux tube interchange driven by the sharp boundary is found, both inward moving flux tubes of hotter plasma and, for the first time, the outward moving cool population. The outward moving cool regions have azimuthal sizes less than 1 RS, were probably created within the past 1.2 h, and have outflow speeds greater than about 5 km/s. At the outer edge of the reconnected region, there is also a possible signature of Dungey-type lobe reconnection following the initial Vasyliunas-type reconnection. Observations from this event are entirely consistent with previously described global MHD simulations of tail reconnection, plasmoid departure, and Saturnward injection of reconnected flux.

  10. Planet formation and searches

    NASA Astrophysics Data System (ADS)

    Montgomery, Ryan Michael

    2009-08-01

    This thesis explores the possibilities for discovery of terrestrial-mass planets in the habitable zones of their host stars. Towards this aim, we present the results of three projects and discuss another two preliminary studies of further explorations. In so doing, we explore a fairly comprehensive range of possibilities regarding the formation and detection of terrestrial- mass planets in the habitable zone. We first study the potential for terrestrial planets to form in situ in and around the habitable zones of M-dwarf stars. We proceed to explore the feasibility of searches for these planets using the transit method via Monte- Carlo simulations. We find that M-dwarfs pose an interesting challenge for study: being inherently dim, widely spread on the sky, and photometrically variable. We present results of simulated ground-based transit search campaigns as well as simulated searches from a modest satellite mission. Our second project is a straightforward extension of the previous study: a collaborative effort to search for transit signals around the nearest M-dwarf: Proxima Centauri. We describe our observations as well as the Monte-Carlo analysis used to place constraints on the possible planetary radii and periods. Our third project is a search for transiting extra-solar Jovian planets using the Rossiter-McLaughlin effect. We search through the private Keck radial- velocity datasets for undiscovered Rossiter-McLaughlin signals. We present our results in the form of both strong null-result datasets as well as potential transiting systems. We then briefly analyze these larger Jovian planets for potential to harbor potentially habitable terrestrial satellites. Our final preliminary analysis looks into the potential for the Large Synoptic Survey Telescope to detect transiting Neptune-mass planets orbiting M-dwarfs which could then lead to terrestrial-mass planet detections. The sum of these efforts is a comprehensive investigation into the likelihood and

  11. Formative Assessment Probes: Is It a Rock? Continuous Formative Assessment

    ERIC Educational Resources Information Center

    Keeley, Page

    2013-01-01

    A lesson plan is provided for a formative assessment probe entitled "Is It a Rock?" This probe is designed for teaching elementary school students about rocks through the use of a formative assessment classroom technique (FACT) known as the group Frayer Model. FACT activates students' thinking about a concept and can be used to…

  12. SU-E-J-03: Characterization of the Precision and Accuracy of a New, Preclinical, MRI-Guided Focused Ultrasound System for Image-Guided Interventions in Small-Bore, High-Field Magnets

    SciTech Connect

    Ellens, N; Farahani, K

    2015-06-15

    Purpose: MRI-guided focused ultrasound (MRgFUS) has many potential and realized applications including controlled heating and localized drug delivery. The development of many of these applications requires extensive preclinical work, much of it in small animal models. The goal of this study is to characterize the spatial targeting accuracy and reproducibility of a preclinical high field MRgFUS system for thermal ablation and drug delivery applications. Methods: The RK300 (FUS Instruments, Toronto, Canada) is a motorized, 2-axis FUS positioning system suitable for small bore (72 mm), high-field MRI systems. The accuracy of the system was assessed in three ways. First, the precision of the system was assessed by sonicating regular grids of 5 mm squares on polystyrene plates and comparing the resulting focal dimples to the intended pattern, thereby assessing the reproducibility and precision of the motion control alone. Second, the targeting accuracy was assessed by imaging a polystyrene plate with randomly drilled holes and replicating the hole pattern by sonicating the observed hole locations on intact polystyrene plates and comparing the results. Third, the practicallyrealizable accuracy and precision were assessed by comparing the locations of transcranial, FUS-induced blood-brain-barrier disruption (BBBD) (observed through Gadolinium enhancement) to the intended targets in a retrospective analysis of animals sonicated for other experiments. Results: The evenly-spaced grids indicated that the precision was 0.11 +/− 0.05 mm. When image-guidance was included by targeting random locations, the accuracy was 0.5 +/− 0.2 mm. The effective accuracy in the four rodent brains assessed was 0.8 +/− 0.6 mm. In all cases, the error appeared normally distributed (p<0.05) in both orthogonal axes, though the left/right error was systematically greater than the superior/inferior error. Conclusions: The targeting accuracy of this device is sub-millimeter, suitable for many

  13. The Formation of Galactic Bulges

    NASA Astrophysics Data System (ADS)

    Carollo, C. Marcella; Ferguson, Henry C.; Wyse, Rosemary F. G.

    2000-03-01

    Part I. Introduction: What are galactic bulges?; Part II. The Epoch of Bulge Formation: Origin of bulges; Deep sub-mm surveys: High-z ULIRGs and the formation of spheroids; Ages and metallicities for stars in the galactic bulge; Integrated stellar populations of bulges: First results; HST-NICMOS observations of galactic bulges: Ages and dust; Inside-out bulge formation and the origin of the Hubble sequence; Part III. The Timescales of Bulge Formation: Constraints on the bulge formation timescale from stellar populations; Bulge building with mergers and winds; Role of winds, starbursts, and activity in bulge formation; Dynamical timescales of bulge formation; Part IV. Physical Processes in Bulge Formation: the role of bars for secular bulge formation; Bars and boxy/peanut-shaped bulges: an observational point of view; Boxy- and peanut-shaped bulges; A new class of bulges; The role of secondary bars in bulge formation; Radial transport of molecular gas to the nuclei of spiral galaxies; Dynamical evolution of bulge shapes; Two-component stellar systems: Phase-space constraints; Central NGC 2146 - a firehose-type bending instability?; Bulge formation: the role of the multi-phase ISM; Global evolution of a self-gravitating multi-phase ISM in the central kpc region of galaxies; Part V. Bulge Phenomenology: Bulge-disk decomposition of spiral galaxies in the near-infrared; The triaxial bulge of NGC 1371; The bulge-disk orthogonal decoupling in galaxies: NGC 4698 and NGC 4672; The kinematics and the origin of the ionized gas in NGC 4036; Optically thin thermal plasma in the galactic bulge; X-ray properties of bulges; The host galaxies of radio-loud AGN; The centers of radio-loud early-type galaxies with HST; Central UV spikes in two galactic spheroids; Conference summary: where do we stand?

  14. The formation of Pangea

    NASA Astrophysics Data System (ADS)

    Stampfli, G. M.; Hochard, C.; Vérard, C.; Wilhem, C.; vonRaumer, J.

    2013-05-01

    The making of Pangea is the result of large-scale amalgamation of continents and micro-continents, which started at the end of the Neoproterozoic with the formation of Gondwana. As pieces were added to Gondwana on its South-American, Antarctica and Australia side, ribbon-like micro-continents were detached from its African and South-Chinese side: Cadomia in the late Neoproterozoic, Avalonia and Hunia in the Ordovician, Galatia in the Devonian and Cimmeria in the Permian. Cadomia was re-accreted to Gondwana, but the other ribbon-continents were accreted to Baltica, North-China, Laurussia or Laurasia. Finding the origin of these numerous terranes is a major geological challenge. Recently, a global plate tectonic model was developed together with a large geological/geodynamic database, at the Lausanne University, covering the last 600 Ma of the Earth's history. Special attention was given to the placing of Gondwana derived terranes in their original position, using all possible constraints. We propose here a solution for the Variscan terranes, another paper deals with the Altaids. The Galatian super-terrane was detached from Gondwana in the Devonian, during the opening of Paleotethys, and was quickly separated into four sub-terranes that started to by-pass each other. The leading terranes collided at the end of the Devonian with the Hanseatic terrane detached from Laurussia. In the Carboniferous, Gondwana started to impinge onto the amalgamated terranes, creating the Variscan chain and the Pangean super-continent. East of Spain Paleotethys remained opened until the Triassic, subducting northward under Laurasia. Roll-back of the Paleotethyan slab triggered the collapse of most of the European Variscan orogen, which was replaced by series of Permian rifts, some of them becoming oceanized back-arc basins during the Triassic. Major force changes at the Pangean plate limits at the end of the Triassic provoked its break-up, through the opening of the proto

  15. SAS FORMATS: USES AND ABUSES

    EPA Science Inventory

    SAS formats are a very powerful tool. They allow you to display the data in a more readable manner without modifying it. Formats can also be used to group data into categories for use in various procedures like PROC FREQ, PROC TTEST, and PROC MEANS (as a class variable). As ...

  16. SAS FORMATS: USES AND ABUSES

    EPA Science Inventory

    SAS formats are a very powerful tool. They allow you to display the data in a more readable manner without modifying it. Formats can also be used to group data into categories for use in various procedures like PROC FREQ, PROC TTEST, and PROC MEANS (as a class variable). As w...

  17. Portable File Format (PFF) specifications.

    SciTech Connect

    Dolan, Daniel H.,

    2015-02-01

    Created at Sandia National Laboratories, the Portable File Format (PFF) allows binary data transfer across computer platforms. Although this capability is supported by many other formats, PFF files are still in use at Sandia, particularly in pulsed power research. This report provides detailed PFF specifications for accessing data without relying on legacy code.

  18. Bibliography Formatting Software: An Update.

    ERIC Educational Resources Information Center

    Stigleman, Sue

    1993-01-01

    Discusses software used for formatting bibliographies and describes 52 programs. Information provided includes type of operating system required, publication formats, citation styles, ability to arrange by subject, use of downloaded references, network versions, costs, and plans for future changes. A directory of the programs and producers is…

  19. Formation Algorithms and Simulation Testbed

    NASA Technical Reports Server (NTRS)

    Wette, Matthew; Sohl, Garett; Scharf, Daniel; Benowitz, Edward

    2004-01-01

    Formation flying for spacecraft is a rapidly developing field that will enable a new era of space science. For one of its missions, the Terrestrial Planet Finder (TPF) project has selected a formation flying interferometer design to detect earth-like planets orbiting distant stars. In order to advance technology needed for the TPF formation flying interferometer, the TPF project has been developing a distributed real-time testbed to demonstrate end-to-end operation of formation flying with TPF-like functionality and precision. This is the Formation Algorithms and Simulation Testbed (FAST) . This FAST was conceived to bring out issues in timing, data fusion, inter-spacecraft communication, inter-spacecraft sensing and system-wide formation robustness. In this paper we describe the FAST and show results from a two-spacecraft formation scenario. The two-spacecraft simulation is the first time that precision end-to-end formation flying operation has been demonstrated in a distributed real-time simulation environment.

  20. The Apennine Bench Formation revisited

    NASA Technical Reports Server (NTRS)

    Spudis, P. D.; Hawke, B. R.

    1985-01-01

    The Apennine Bench Formation consists of pre-mare light plains materials that crop out south of the crater Archimedes, inside the Imbrium basin. This material was ascribed to either impact or volcanic origins. The characteristics of Apollo 15 KREEP basalts and the Apennine Bench Formation are reviewed to determine whether their characteristics are compatible with a volcanic origin.

  1. Star formation in the multiverse

    SciTech Connect

    Bousso, Raphael; Leichenauer, Stefan

    2009-03-15

    We develop a simple semianalytic model of the star formation rate as a function of time. We estimate the star formation rate for a wide range of values of the cosmological constant, spatial curvature, and primordial density contrast. Our model can predict such parameters in the multiverse, if the underlying theory landscape and the cosmological measure are known.

  2. Tariffs Formation on oil transportation

    NASA Astrophysics Data System (ADS)

    Glyzina, T. S.; Kolbysheva, Yu. V.; Grivtsova, I. S.; Dmitrieva, N. V.

    2016-09-01

    Oil transportation via trunk pipelines is an important part of the oil industry's activity. The main instrument of tariff regulation is the method of tariffs formation. Three methods of tariffs formation such as the method of economically justified costs (the Cost plus method), the method of economically justified return on investment capital (the RAB method), and the method of tariffs indexation were considered.

  3. Formative Assessment: A Critical Review

    ERIC Educational Resources Information Center

    Bennett, Randy Elliot

    2011-01-01

    This paper covers six interrelated issues in formative assessment (aka, "assessment for learning"). The issues concern the definition of formative assessment, the claims commonly made for its effectiveness, the limited attention given to domain considerations in its conceptualisation, the under-representation of measurement principles in that…

  4. Sibling similarity in family formation.

    PubMed

    Raab, Marcel; Fasang, Anette Eva; Karhula, Aleksi; Erola, Jani

    2014-12-01

    Sibling studies have been widely used to analyze the impact of family background on socioeconomic and, to a lesser extent, demographic outcomes. We contribute to this literature with a novel research design that combines sibling comparisons and sequence analysis to analyze longitudinal family-formation trajectories of siblings and unrelated persons. This allows us to scrutinize in a more rigorous way whether sibling similarity exists in family-formation trajectories and whether siblings' shared background characteristics, such as parental education and early childhood family structure, can account for similarity in family formation. We use Finnish register data from 1987 through 2007 to construct longitudinal family-formation trajectories in young adulthood for siblings and unrelated dyads (N = 14,257 dyads). Findings show that family formation is moderately but significantly more similar for siblings than for unrelated dyads, also after controlling for crucial parental background characteristics. Shared parental background characteristics add surprisingly little to account for sibling similarity in family formation. Instead, gender and the respondents' own education are more decisive forces in the stratification of family formation. Yet, family internal dynamics seem to reinforce this stratification such that siblings have a higher probability to experience similar family-formation patterns. In particular, patterns that correspond with economic disadvantage are concentrated within families. This is in line with a growing body of research highlighting the importance of family structure in the reproduction of social inequality.

  5. Cyanide Formation by Chromobacterium violaceum

    PubMed Central

    Michaels, Ruth; Corpe, W. A.

    1965-01-01

    Michaels, Ruth (Columbia University, New York, N.Y.), and W. A. Corpe. Cyanide formation by Chromobacterium violaceum. J. Bacteriol. 89:106–112. 1965.—The formation of cyanide by a Chromobacterium violaceum strain was studied with growing cultures and with nonproliferating cells grown in complex and chemically defined media. Most of the cyanide was produced during the log-phase growth of the organism, and accumulated in the culture supernatant fluid. A synergistic effect of glycine and methionine on cyanide formation in a chemically defined medium was observed, and the amount of cyanide formed was found to be dependent on the concentrations of the two substances. Cyanide formation by nonproliferating cells was stimulated by preincubation with glycine and methionine. Cyanide formation by adapted cells in the presence of glycine and methionine was stimulated by succinate, malate, or fumarate, and depressed by azide and 2,4-dinitrophenol. Methionine could be replaced by betaine, dimethylglycine, and choline. PMID:14255648

  6. Physics of primordial star formation

    NASA Astrophysics Data System (ADS)

    Yoshida, Naoki

    2012-09-01

    The study of primordial star formation has a history of nearly sixty years. It is generally thought that primordial stars are one of the key elements in a broad range of topics in astronomy and cosmology, from Galactic chemical evolution to the formation of super-massive blackholes. We review recent progress in the theory of primordial star formation. The standard theory of cosmic structure formation posits that the present-day rich structure of the Universe developed through gravitational amplification of tiny matter density fluctuations left over from the Big Bang. It has become possible to study primordial star formation rigorously within the framework of the standard cosmological model. We first lay out the key physical processes in a primordial gas. Then, we introduce recent developments in computer simulations. Finally, we discuss prospects for future observations of the first generation of stars.

  7. High resolution NMR measurements using a 400MHz NMR with an (RE)Ba2Cu3O7-x high-temperature superconducting inner coil: Towards a compact super-high-field NMR.

    PubMed

    Piao, R; Iguchi, S; Hamada, M; Matsumoto, S; Suematsu, H; Saito, A T; Li, J; Nakagome, H; Takao, T; Takahashi, M; Maeda, H; Yanagisawa, Y

    2016-02-01

    Use of high-temperature superconducting (HTS) inner coils in combination with conventional low-temperature superconducting (LTS) outer coils for an NMR magnet, i.e. a LTS/HTS NMR magnet, is a suitable option to realize a high-resolution NMR spectrometer with operating frequency >1GHz. From the standpoint of creating a compact magnet, (RE: Rare earth) Ba2Cu3O7-x (REBCO) HTS inner coils which can tolerate a strong hoop stress caused by a Lorentz force are preferred. However, in our previous work on a first-generation 400MHz LTS/REBCO NMR magnet, the NMR resolution and sensitivity were about ten times worse than that of a conventional LTS NMR magnet. The result was caused by a large field inhomogeneity in the REBCO coil itself and the shielding effect of a screening current induced in that coil. In the present paper, we describe the operation of a modified 400MHz LTS/REBCO NMR magnet with an advanced field compensation technology using a combination of novel ferromagnetic shimming and an appropriate procedure for NMR spectrum line shape optimization. We succeeded in obtaining a good NMR line shape and 2D NOESY spectrum for a lysozyme aqueous sample. We believe that this technology is indispensable for the realization of a compact super-high-field high-resolution NMR. PMID:26778351

  8. Dissipative processes in galaxy formation.

    PubMed Central

    Silk, J

    1993-01-01

    A galaxy commences its life in a diffuse gas cloud that evolves into a predominantly stellar aggregation. Considerable dissipation of gravitational binding energy occurs during this transition. I review here the dissipative processes that determine the critical scales of luminous galaxies and the generation of their morphology. The universal scaling relations for spirals and ellipticals are shown to be sensitive to the history of star formation. Semiphenomenological expressions are given for star-formation rates in protogalaxies and in starbursts. Implications are described for elliptical galaxy formation and for the evolution of disk galaxies. PMID:11607396

  9. Antihydrogen Formation using Cold Plasmas

    SciTech Connect

    Madsen, N.; Bowe, P.D.; Hangst, J.S.; Amoretti, M.; Carraro, C.; Macri, M.; Testera, G.; Variola, A.; Amsler, C.; Johnson, I.; Pruys, H.; Regenfus, C.; Bonomi, G.; Bouchta, A.; Doser, M.; Kellerbauer, A.; Landua, R.; Cesar, C.L.; Charlton, M.; Joergensen, L.V.

    2004-10-20

    Antihydrogen, the antimatter counterpart of the hydrogen atom, can be formed by mixing cold samples of antiprotons and positrons. In 2002 the ATHENA collaboration succeeded in the first production of cold antihydrogen. By observing and imaging the annihilation products of the neutral, non-confined, antihydrogen atoms annihilating on the walls of the trap we can observe the production in quasi-real-time and study the dynamics of the formation mechanism. The formation mechanism strongly influences the final state of the formed antihydrogen atoms, important for future spectroscopic comparison with hydrogen. This paper briefly summarizes the current understanding of the antihydrogen formation in ATHENA.

  10. Dynamics of rock varnish formation

    SciTech Connect

    Raymond, R. Jr.; Reneau, S.L.; Guthrie, G.D. Jr.; Bish, D.L.; Harrington, C.D.

    1991-01-01

    Our studies of rock varnish from the southwestern United States suggest that the Mn-phase in rock varnish has neither the chemistry nor the crystal structure of birnessite. Rather, the Mn-rich phase is non-crystalline and contains Ba, Ca, Fe, Al, and P. Unknowns concerning the formation of this non-crystalline Mn phase must be resolved before researchers are able to define chemical parameters of rock varnish formation based upon conditions of formation of the Mn phase. 6 refs., 9 figs.

  11. Formate dehydrogenase from Pseudomonas oxalaticus.

    PubMed

    Müller, U; Willnow, P; Ruschig, U; Höpner, T

    1978-02-01

    Formate dehydrogenase (EC 1.2.1.2) from Pseudomonas oxalaticus has been isolated and characterized. The enzyme (molecular weight 315000) is a complex flavoprotein containing 2 FMN, 18--25 non-heme iron atoms and 15--20 acid-labile sulphides. In the last step of the purification, a sucrose gradient centrifugation, a second catalytically active species has been found apparently originating from a dissociation of the enzyme into two equal subunits. The enzyme is specific toward its natural substrate formate. It transfers electrons to NAD+, oxygen, ferricyanide, and a lot of nonphysiological acceptors (dyes). In addition electrons are transferred from NADH to these acceptors. The (reversible) removal of FMN requires a reduction step. Reincorporation has been followed by the reappearance of the reactivity against formate and by fluorescence titration. The deflavo enzyme also binds FAD and riboflavin. The resulting enzyme species show characteristic catalytic abilities. Activity against formate is peculiar to the FMN species. PMID:631130

  12. Results of Aluminosilicate Formation Testing

    SciTech Connect

    Wilmarth, W.R.

    2001-09-11

    The purpose of this work was to examine several experimental parameters of the formation of aluminosilicates under several tank chemistries, examine the conversion of crystalline phases, and determine inherent solubilities of certain crystal phases.

  13. Ultraviolet Mars Reveals Cloud Formation

    NASA Video Gallery

    Images from MAVEN's Imaging UltraViolet Spectrograph were used to make this movie of rapid cloud formation on Mars on July 9-10, 2016. The ultraviolet colors of the planet have been rendered in fal...

  14. Strong enhancement of high-field critical current properties and irreversibility field of MgB2 superconducting wires by coronene active carbon source addition via the new B powder carbon-coating method

    NASA Astrophysics Data System (ADS)

    Ye, Shu Jun; Matsumoto, Akiyoshi; Chao Zhang, Yun; Kumakura, Hiroaki

    2014-08-01

    We report an effective carbon-containing additive, coronene (C24H12), for MgB2 superconducting wires. We used B powder coated with C24H12 to fabricate MgB2 wires using the powder-in-tube (PIT) and internal Mg diffusion (IMD) processes. The in-field critical current properties are strongly enhanced for both PIT- and IMD-processed MgB2 wires. For PIT MgB2 wires, a critical current density (Jc) value of 1.8 × 104 A cm-2 is obtained at 4.2 K and 10 T. For IMD MgB2 wires, we obtained a Jc of 1.07 × 105 A cm-2 and an engineering Jc (Je) of 1.12 × 104 A cm-2 at 4.2 K and 10 T. These Jc and Je values are similar to the highest values reported for MgB2 wires thus far. Furthermore, the irreversibility field, Birr, determined with a current density criterion of 100 A cm-2, is strongly enhanced to 25 T at 4.2 K, which is also the highest value reported for MgB2 superconducting wires thus far. Coronene is an active carbon source for MgB2 superconducting wires because (1) coronene has a high carbon content (96 wt%) with a small amount of hydrogen (impurity), (2) the decomposition temperature for coronene is near the reaction temperature between Mg and B, and (3) uniform dispersion of coronene on the B surface can be obtained due to the melting point of coronene being lower than the decomposition temperature. Carbon substitution for B caused by the coronene active carbon source is mainly responsible for the high field critical current properties and the high Birr obtained in this work.

  15. Globally conditioned Granger causality in brain-brain and brain-heart interactions: a combined heart rate variability/ultra-high-field (7 T) functional magnetic resonance imaging study.

    PubMed

    Duggento, Andrea; Bianciardi, Marta; Passamonti, Luca; Wald, Lawrence L; Guerrisi, Maria; Barbieri, Riccardo; Toschi, Nicola

    2016-05-13

    The causal, directed interactions between brain regions at rest (brain-brain networks) and between resting-state brain activity and autonomic nervous system (ANS) outflow (brain-heart links) have not been completely elucidated. We collected 7 T resting-state functional magnetic resonance imaging (fMRI) data with simultaneous respiration and heartbeat recordings in nine healthy volunteers to investigate (i) the causal interactions between cortical and subcortical brain regions at rest and (ii) the causal interactions between resting-state brain activity and the ANS as quantified through a probabilistic, point-process-based heartbeat model which generates dynamical estimates for sympathetic and parasympathetic activity as well as sympathovagal balance. Given the high amount of information shared between brain-derived signals, we compared the results of traditional bivariate Granger causality (GC) with a globally conditioned approach which evaluated the additional influence of each brain region on the causal target while factoring out effects concomitantly mediated by other brain regions. The bivariate approach resulted in a large number of possibly spurious causal brain-brain links, while, using the globally conditioned approach, we demonstrated the existence of significant selective causal links between cortical/subcortical brain regions and sympathetic and parasympathetic modulation as well as sympathovagal balance. In particular, we demonstrated a causal role of the amygdala, hypothalamus, brainstem and, among others, medial, middle and superior frontal gyri, superior temporal pole, paracentral lobule and cerebellar regions in modulating the so-called central autonomic network (CAN). In summary, we show that, provided proper conditioning is employed to eliminate spurious causalities, ultra-high-field functional imaging coupled with physiological signal acquisition and GC analysis is able to quantify directed brain-brain and brain-heart interactions reflecting

  16. Star Formation Across Galactic Environments

    NASA Astrophysics Data System (ADS)

    Young, Jason

    2013-01-01

    I present here parallel investigations of star formation in AGN-free and quasar host galaxies. These environments are both insightful; quasars are among the most violent objects known, reshaping their host galaxies, while my sample of AGN-free star-forming galaxies ranges from systems larger than the Milky Way to dwarf star-forming galaxies. The AGN-free galaxies are drawn from the KPNO International Spectroscopic Survey, an Hα-selected, volume-limited survey was designed to avoid continuum luminosity bias. This work studies the KISS galaxies in mid- and far-IR using Spitzer IRAC and MIPS photometry. These IR bands are interesting because the UV light from young stars is reprocessed into thermal emission in the far-IR (24μm MIPS) by dust and into vibrational transition features in the mid-IR (8.0μm IRAC) by polycyclic aromatic hydrocarbons (PAHs). This work examines the efficiencies of PAH and dust emission as tracers of star-formation. I find that the efficiency of PAH as a star-formation tracer varies with galactic stellar mass, while thermal dust has no systematic dependance on galactic mass. My study of quasar host galaxies utilizes images of eight PG quasars from the WFPC2 and NICMOS instruments aboard HST. I use narrow-band images centered on the Hβ, [OII]λ3727, [OIII]λ5007, and Paα emission lines to construct extinction and star formation maps. Additionally, I use line-ratio maps to distinguish AGN-powered line emission from star formation powered line emission. I find star formation, albeit at rates are lower than expected, suggesting that quasar host galaxies are dynamically more advanced than suspected. Seven of the galaxies have higher mass-specific star-formation rates. Additionally, I see evidence of shocked gas, supporting the hypotheses from earlier works that AGN activity quenches star formation in host galaxies by disrupting gas reservoirs.

  17. Cosmic strings and galaxy formation

    NASA Technical Reports Server (NTRS)

    Bertschinger, Edmund

    1989-01-01

    The cosmogonical model proposed by Zel'dovich and Vilenkin (1981), in which superconducting cosmic strings act as seeds for the origin of structure in the universe, is discussed, summarizing the results of recent theoretical investigations. Consideration is given to the formation of cosmic strings, the microscopic structure of strings, gravitational effects, cosmic string evolution, and the formation of galaxies and large-scale structure. Simulation results are presented in graphs, and several outstanding issues are listed and briefly characterized.

  18. Star formation in dwarf galaxies

    NASA Astrophysics Data System (ADS)

    Dong, Shawfeng

    In this thesis, we examine the star formation history and stellar feedback effects of dwarf galaxies under the influence of extragalactic ultraviolet radiation, as well as the evolution of residual gas within tidally-limited dwarf galaxies and globular clusters. Previous work has indicated that the background UV flux can easily ionize the gas within typical dwarf galaxies, delaying or even preventing cooling and star formation within them. Many dwarf galaxies within the Local Group are, however, observed to contain multiple generations of stars, the oldest of which formed in the early epochs of cosmic evolution, when the background UV flux was intense. In order to address this paradox, we consider the dynamical evolution of gas in dwarf galaxies using a one-dimensional, spherically symmetric, Lagrangian numerical scheme which also computes the effects of radiative transfer and photoionization. We include in the scheme a physically-motivated star formation recipe and consider the effects of feedback. This scheme allows us to follow the history of the gas and of star formation within dwarf galaxies, as influenced by both external and internal UV radiation. Our results indicate that star formation in the severe environment of dwarf galaxies is a difficult and inefficient process. In potentials with total mass less than a few 106 M⊙ , and velocity dispersion less than a few km s-1 , residual gas is efficiently photoionized by cosmic background UV radiation. For intermediate mass systems, such as the dSphs around the Galaxy, star formation can proceed within early cosmic epochs despite the intense background UV flux. Triggering processes such as merger events, collisions, and tidal disturbance can lead to density enhancements, reducing the recombination timescale, allowing gas to cool and star formation to proceed. However, the star formation and gas retention efficiency may vary widely in galaxies with similar dark matter potentials, because they depend on many

  19. Treating tar sands formations with karsted zones

    SciTech Connect

    Vinegar, Harold J.; Karanikas, John Michael

    2010-03-09

    Methods for treating a tar sands formation are described herein. The tar sands formation may have one or more karsted zones. Methods may include providing heat from one or more heaters to one or more karsted zones of the tar sands formation to mobilize fluids in the formation. At least some of the mobilized fluids may be produced from the formation.

  20. Isolated star formation: from cloud formation to core collapse.

    PubMed

    Ward-Thompson, Derek

    2002-01-01

    The formation of stars is one of the most fundamental problems in astrophysics, as it underlies many other questions, on scales from the formation of galaxies to the formation of the solar system. The physical processes involve the turbulent behavior of a partially ionized medium containing a non-uniform magnetic field. Current debate centers around the time taken for turbulence to decay and the relative importance of the roles played by magnetic fields and turbulence. Technological advances such as millimeter-wave cameras have made possible observations of the temperature and density profiles, and statistical calculations of the lifetimes, of objects collapsing under their own self-gravity and those on the verge of collapse. Increased computing power allows more complex models to be made that include magnetic and turbulent effects. No current model can reproduce all of the observations. PMID:11778038