The Fourier-Kelvin Stellar Interferometer a Low Complexity, Low Cost Space Mission for High-Resolution Astronomy and Direct Exoplanet Detection

NASA Technical Reports Server (NTRS)

Barry, R. K.; Danchi, W. C.; Deming, L. D.; Richardson, L. J.; Kuchner, M. J.; Seager, S.; Frey, B. J.; Martino, A. J.; Lee, K. A.; Zuray, M.;

Detection of proximal caries using digital radiographic systems with different resolutions.

PubMed

Nikneshan, Sima; Abbas, Fatemeh Mashhadi; Sabbagh, Sedigheh

2015-01-01

Dental radiography is an important tool for detection of caries and digital radiography is the latest advancement in this regard. Spatial resolution is a characteristic of digital receptors used for describing the quality of images. This study was aimed to compare the diagnostic accuracy of two digital radiographic systems with three different resolutions for detection of noncavitated proximal caries. Diagnostic accuracy. Seventy premolar teeth were mounted in 14 gypsum blocks. Digora; Optime and RVG Access were used for obtaining digital radiographs. Six observers evaluated the proximal surfaces in radiographs for each resolution in order to determine the depth of caries based on a 4-point scale. The teeth were then histologically sectioned, and the results of histologic analysis were considered as the gold standard. Data were entered using SPSS version 18 software and the Kruskal-Wallis test was used for data analysis. P <0.05 was considered as statistically significant. No significant difference was found between different resolutions for detection of proximal caries (P > 0.05). RVG access system had the highest specificity (87.7%) and Digora; Optime at high resolution had the lowest specificity (84.2%). Furthermore, Digora; Optime had higher sensitivity for detection of caries exceeding outer half of enamel. Judgment of oral radiologists for detection of the depth of caries had higher reliability than that of restorative dentistry specialists. The three resolutions of Digora; Optime and RVG access had similar accuracy in detection of noncavitated proximal caries.

Signal detectability in diffusive media using phased arrays in conjunction with detector arrays.

PubMed

Kang, Dongyel; Kupinski, Matthew A

2011-06-20

We investigate Hotelling observer performance (i.e., signal detectability) of a phased array system for tasks of detecting small inhomogeneities and distinguishing adjacent abnormalities in uniform diffusive media. Unlike conventional phased array systems where a single detector is located on the interface between two sources, we consider a detector array, such as a CCD, on a phantom exit surface for calculating the Hotelling observer detectability. The signal detectability for adjacent small abnormalities (2 mm displacement) for the CCD-based phased array is related to the resolution of reconstructed images. Simulations show that acquiring high-dimensional data from a detector array in a phased array system dramatically improves the detectability for both tasks when compared to conventional single detector measurements, especially at low modulation frequencies. It is also observed in all studied cases that there exists the modulation frequency optimizing CCD-based phased array systems, where detectability for both tasks is consistently high. These results imply that the CCD-based phased array has the potential to achieve high resolution and signal detectability in tomographic diffusive imaging while operating at a very low modulation frequency. The effect of other configuration parameters, such as a detector pixel size, on the observer performance is also discussed.

Study of multi-channel optical system based on the compound eye

NASA Astrophysics Data System (ADS)

Zhao, Yu; Fu, Yuegang; Liu, Zhiying; Dong, Zhengchao

2014-09-01

As an important part of machine vision, compound eye optical systems have the characteristics of high resolution and large FOV. By applying the compound eye optical systems to target detection and recognition, the contradiction between large FOV and high resolution in the traditional single aperture optical systems could be solved effectively and also the parallel processing ability of the optical systems could be sufficiently shown. In this paper, the imaging features of the compound eye optical systems are analyzed. After discussing the relationship between the FOV in each subsystem and the contact ratio of the FOV in the whole system, a method to define the FOV of the subsystem is presented. And a compound eye optical system is designed, which is based on the large FOV synthesized of multi-channels. The compound eye optical system consists with a central optical system and array subsystem, in which the array subsystem is used to capture the target. The high resolution image of the target could be achieved by the central optical system. With the advantage of small volume, light weight and rapid response speed, the optical system could detect the objects which are in 3km and FOV of 60°without any scanning device. The objects in the central field 2w=5.1°could be imaged with high resolution so that the objects could be recognized.

Label-free imaging of cellular malformation using high resolution photoacoustic microscopy

NASA Astrophysics Data System (ADS)

Chen, Zhongjiang; Li, Bingbing; Yang, Sihua

2014-09-01

A label-free high resolution photoacoustic microscopy (PAM) system for imaging cellular malformation is presented. The carbon fibers were used to testify the lateral resolution of the PAM. Currently, the lateral resolution is better than 2.7 μm. The human normal red blood cells (RBCs) were used to prove the imaging capability of the system, and a single red blood cell was mapped with high contrast. Moreover, the iron deficiency anemia RBCs were clearly distinguished from the cell morphology by using the PAM. The experimental results demonstrate that the photoacoustic microscopy system can accomplish label-free photoacoustic imaging and that it has clinical potential for use in the detection of erythrocytes and blood vessels malformation.

Assessment of a vertical high-resolution distributed-temperature-sensing system in a shallow thermohaline environment

NASA Astrophysics Data System (ADS)

Suárez, F.; Aravena, J. E.; Hausner, M. B.; Childress, A. E.; Tyler, S. W.

2011-03-01

In shallow thermohaline-driven lakes it is important to measure temperature on fine spatial and temporal scales to detect stratification or different hydrodynamic regimes. Raman spectra distributed temperature sensing (DTS) is an approach available to provide high spatial and temporal temperature resolution. A vertical high-resolution DTS system was constructed to overcome the problems of typical methods used in the past, i.e., without disturbing the water column, and with resistance to corrosive environments. This paper describes a method to quantitatively assess accuracy, precision and other limitations of DTS systems to fully utilize the capacity of this technology, with a focus on vertical high-resolution to measure temperatures in shallow thermohaline environments. It also presents a new method to manually calibrate temperatures along the optical fiber achieving significant improved resolution. The vertical high-resolution DTS system is used to monitor the thermal behavior of a salt-gradient solar pond, which is an engineered shallow thermohaline system that allows collection and storage of solar energy for a long period of time. The vertical high-resolution DTS system monitors the temperature profile each 1.1 cm vertically and in time averages as small as 10 s. Temperature resolution as low as 0.035 °C is obtained when the data are collected at 5-min intervals.

Linac coherent light source (LCLS) undulator RF BPM system.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lill, R.; Waldschmidt, G.; Morrison, L.

2006-01-01

The Linac Coherent Light Source (LCLS) will be the world's first x-ray free-electron laser (FEL) when it becomes operational in 2009. The LCLS is currently in the construction phase. The beam position monitor (BPM) system planned for the LCLS undulator will incorporate a high-resolution X-band cavity BPM system described in this paper. The BPM system will provide high-resolution measurements of the electron beam trajectory on a pulse-to-pulse basis and over many shots. The X-band cavity BPM size, simple fabrication, and high resolution make it an ideal choice for LCLS beam position detection. We will discuss the system specifications, design, andmore » prototype test results.« less

Linac Coherent Light Source Undulator RF BPM System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lill, R.M.; Morrison, L.H.; Waldschmidt, G.J.

2007-04-17

The Linac Coherent Light Source (LCLS) will be the world's first x-ray free-electron laser (FEL) when it becomes operational in 2009. The LCLS is currently in the construction phase. The beam position monitor (BPM) system planned for the LCLS undulator will incorporate a high-resolution X-band cavity BPM system described in this paper. The BPM system will provide high-resolution measurements of the electron beam trajectory on a pulse-to-pulse basis and over many shots. The X-band cavity BPM size, simple fabrication, and high resolution make it an ideal choice for LCLS beam position detection. We will discuss the system specifications, design, andmore » prototype test results.« less

High resolution, high rate x-ray spectrometer

DOEpatents

Goulding, F.S.; Landis, D.A.

1983-07-14

It is an object of the invention to provide a pulse processing system for use with detected signals of a wide dynamic range which is capable of very high counting rates, with high throughput, with excellent energy resolution and a high signal-to-noise ratio. It is a further object to provide a pulse processing system wherein the fast channel resolving time is quite short and substantially independent of the energy of the detected signals. Another object is to provide a pulse processing system having a pile-up rejector circuit which will allow the maximum number of non-interfering pulses to be passed to the output. It is also an object of the invention to provide new methods for generating substantially symmetrically triangular pulses for use in both the main and fast channels of a pulse processing system.

Cooperative multisensor system for real-time face detection and tracking in uncontrolled conditions

NASA Astrophysics Data System (ADS)

Marchesotti, Luca; Piva, Stefano; Turolla, Andrea; Minetti, Deborah; Regazzoni, Carlo S.

2005-03-01

The presented work describes an innovative architecture for multi-sensor distributed video surveillance applications. The aim of the system is to track moving objects in outdoor environments with a cooperative strategy exploiting two video cameras. The system also exhibits the capacity of focusing its attention on the faces of detected pedestrians collecting snapshot frames of face images, by segmenting and tracking them over time at different resolution. The system is designed to employ two video cameras in a cooperative client/server structure: the first camera monitors the entire area of interest and detects the moving objects using change detection techniques. The detected objects are tracked over time and their position is indicated on a map representing the monitored area. The objects" coordinates are sent to the server sensor in order to point its zooming optics towards the moving object. The second camera tracks the objects at high resolution. As well as the client camera, this sensor is calibrated and the position of the object detected on the image plane reference system is translated in its coordinates referred to the same area map. In the map common reference system, data fusion techniques are applied to achieve a more precise and robust estimation of the objects" track and to perform face detection and tracking. The work novelties and strength reside in the cooperative multi-sensor approach, in the high resolution long distance tracking and in the automatic collection of biometric data such as a person face clip for recognition purposes.

High-resolution 3D laser imaging based on tunable fiber array link

NASA Astrophysics Data System (ADS)

Zhao, Sisi; Ruan, Ningjuan; Yang, Song

2017-10-01

Airborne photoelectric reconnaissance system with the bore sight down to the ground is an important battlefield situational awareness system, which can be used for reconnaissance and surveillance of complex ground scene. Airborne 3D imaging Lidar system is recognized as the most potential candidates for target detection under the complex background, and is progressing in the directions of high resolution, long distance detection, high sensitivity, low power consumption, high reliability, eye safe and multi-functional. However, the traditional 3D laser imaging system has the disadvantages of lower imaging resolutions because of the small size of the existing detector, and large volume. This paper proposes a high resolution laser 3D imaging technology based on the tunable optical fiber array link. The echo signal is modulated by a tunable optical fiber array link and then transmitted to the focal plane detector. The detector converts the optical signal into electrical signals which is given to the computer. Then, the computer accomplishes the signal calculation and image restoration based on modulation information, and then reconstructs the target image. This paper establishes the mathematical model of tunable optical fiber array signal receiving link, and proposes the simulation and analysis of the affect factors on high density multidimensional point cloud reconstruction.

Fiber optic quench detection via optimized Rayleigh Scattering in high-field YBCO accelerator magnets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Flanagan, Gene

Yttrium barium copper oxide (YBCO) coated conductors are known for their ability to operate in the superconducting state at relatively high temperatures, even above the boiling point of liquid nitrogen (77 K). When these same conductors are operated at lower temperatures, they are able to operate in much higher magnetic fields than traditional superconductors like NiTi or Nb 3Sn. Thus, YBCO superconducting magnets are one of the primary options for generating the high magnetic fields needed for future high energy physics devices. Due to slow quench propagation, quench detection remains one of the primary limitations to YBCO magnets. Fiber opticmore » sensing, based upon Rayleigh scattering, has the potential for spatial resolution approaching the wavelength of light, or very fast temporal resolution at low spatial resolution, and a continuum of combinations in between. This project has studied, theoretically and experimentally, YBCO magnets and Rayleigh scattering quench detection systems to demonstrate feasibility of the systems for YBCO quench protection systems. Under this grant an experimentally validated 3D quench propagation model was used to accurately define the acceptable range of spatial and temporal resolutions for effective quench detection in YBCO magnets and to evaluate present-day and potentially improved YBCO conductors. The data volume and speed requirements for quench detection via Rayleigh scattering required the development of a high performance fiber optic based quench detection/data acquisition system and its integration with an existing voltage tap/thermo-couple based system. In this project, optical fibers are tightly co-wound into YBCO magnet coils, with the fiber on top of the conductor as turn-to-turn insulation. Local changes in the temperature or strain of the conductor are sensed by the optical fiber, which is in close thermal and mechanical contact with the conductor. Intrinsic imperfections in the fiber reflect Rayleigh backscattered laser signals that are shifted by the changes in the fiber that are induced by a local change in the YBCO temperature or strain. One goal of this project was to show that modern technology can be used to interrogate the signals from a (very expensive) YBCO magnet to detect an impending quench in time to protect it from self-destruction. The results show that Rayleigh-backscattering interrogated optical fibers (RIOF) have significant advantages over traditional techniques, including very high spatial resolution and the ability to detect a hot-spot well before the peak local temperature becomes so high that the conductor can be damaged. RIOF quench detection is intrinsically faster than voltage taps, and this intrinsic advantage is greater as the coil size and/or current margin increases. We describe the development and testing program performed under the grant.« less

Time-resolved lidar fluorosensor for sea pollution detection

NASA Technical Reports Server (NTRS)

Ferrario, A.; Pizzolati, P. L.; Zanzottera, E.

1986-01-01

A contemporary time and spectral analysis of oil fluorescence is useful for the detection and the characterization of oil spills on the sea surface. Nevertheless the fluorosensor lidars, which were realized up to now, have only partial capability to perform this double analysis. The main difficulties are the high resolution required (of the order of 1 nanosecond) and the complexity of the detection system for the recording of a two-dimensional matrix of data for each laser pulse. An airborne system whose major specifications were: time range, 30 to 75 ns; time resolution, 1 ns; spectral range, 350 to 700 nm; and spectral resolution, 10 nm was designed and constructed. The designed system of a short pulse ultraviolet laser source and a streak camera based detector are described.

High-Resolution Magnetic Analyzer MAVR for the Study of Exotic Weakly-Bound Nuclei

NASA Astrophysics Data System (ADS)

Maslov, V. A.; Kazacha, V. I.; Kolesov, I. V.; Lukyanov, S. M.; Melnikov, V. N.; Osipov, N. F.; Penionzhkevich, Yu. E.; Skobelev, N. K.; Sobolev, Yu. G.; Voskoboinik, E. I.

2015-11-01

A project of the high-resolution magnetic analyzer MAVR is proposed. The analyzer will comprise new magnetic optical and detecting systems for separation and identification of reaction products in a wide range of masses (5-150) and charges (1-60). The magnetic optical system consists of the MSP-144 magnet and a doublet of quadrupole lenses. This will allow the solid angle of the spectrometer to be increased by an order of magnitude up to 30 msr. The magnetic analyzer will have a high momentum resolution (10-4) and high focal-plane dispersion (1.9 m). It will allow products of nuclear reactions at energies up to 30 MeV/nucleon to be detected with the charge resolution ~1/60. Implementation of the project is divided into two stages: conversion of the magnetic analyzer proper and construction of the nuclear reaction products identification system. The MULTI detecting system is being developed for the MAVR magnetic analyzer to allow detection of nuclear reaction products and their identification by charge Q, atomic number Z, and mass A with a high absolute accuracy. The identification will be performed by measuring the energy loss (ΔE), time of flight (TOF), and total kinetic energy (TKE) of reaction products. The particle trajectories in the analyzer will also be determined using the drift chamber developed jointly with GANIL. The MAVR analyzer will operate in both primary beams of heavy ions and beams of radioactive nuclei produced by the U400-U400M acceleration complex. It will also be used for measuring energy spectra of nuclear reaction products and as an energy monochromator.

High resolution colonoscopy in a bowel cancer screening program improves polyp detection

PubMed Central

Banks, Matthew R; Haidry, Rehan; Butt, M Adil; Whitley, Lisa; Stein, Judith; Langmead, Louise; Bloom, Stuart L; O’Bichere, Austin; McCartney, Sara; Basherdas, Kalpesh; Rodriguez-Justo, Manuel; Lovat, Laurence B

2011-01-01

AIM: To compare high resolution colonoscopy (Olympus Lucera) with a megapixel high resolution system (Pentax HiLine) as an in-service evaluation. METHODS: Polyp detection rates and measures of performance were collected for 269 colonoscopy procedures. Five colonoscopists conducted the study over a three month period, as part of the United Kingdom bowel cancer screening program. RESULTS:There were no differences in procedure duration (χ2 P = 0.98), caecal intubation rates (χ2 P = 0.67), or depth of sedation (χ2 P = 0.64). Mild discomfort was more common in the Pentax group (χ2 P = 0.036). Adenoma detection rate was significantly higher in the Pentax group (χ2 test for trend P = 0.01). Most of the extra polyps detected were flat or sessile adenomas. CONCLUSION: Megapixel definition colonoscopes improve adenoma detection without compromising other measures of endoscope performance. Increased polyp detection rates may improve future outcomes in bowel cancer screening programs. PMID:22090787

High-emulation mask recognition with high-resolution hyperspectral video capture system

NASA Astrophysics Data System (ADS)

Feng, Jiao; Fang, Xiaojing; Li, Shoufeng; Wang, Yongjin

2014-11-01

We present a method for distinguishing human face from high-emulation mask, which is increasingly used by criminals for activities such as stealing card numbers and passwords on ATM. Traditional facial recognition technique is difficult to detect such camouflaged criminals. In this paper, we use the high-resolution hyperspectral video capture system to detect high-emulation mask. A RGB camera is used for traditional facial recognition. A prism and a gray scale camera are used to capture spectral information of the observed face. Experiments show that mask made of silica gel has different spectral reflectance compared with the human skin. As multispectral image offers additional spectral information about physical characteristics, high-emulation mask can be easily recognized.

Detecting Uniform Areas for Vicarious Calibration using Landsat TM Imagery: A Study using the Arabian and Saharan Deserts

NASA Technical Reports Server (NTRS)

Hilbert, Kent; Pagnutti, Mary; Ryan, Robert; Zanoni, Vicki

2002-01-01

This paper discusses a method for detecting spatially uniform sites need for radiometric characterization of remote sensing satellites. Such information is critical for scientific research applications of imagery having moderate to high resolutions (<30-m ground sampling distance (GSD)). Previously published literature indicated that areas with the African Saharan and Arabian deserts contained extremely uniform sites with respect to spatial characteristics. We developed an algorithm for detecting site uniformity and applied it to orthorectified Landsat Thematic Mapper (TM) imagery over eight uniform regions of interest. The algorithm's results were assessed using both medium-resolution (30-m GSD) Landsat 7 ETM+ and fine-resolution (<5-m GSD) IKONOS multispectral data collected over sites in Libya and Mali. Fine-resolution imagery over a Libyan site exhibited less than 1 percent nonuniformity. The research shows that Landsat TM products appear highly useful for detecting potential calibration sites for system characterization. In particular, the approach detected spatially uniform regions that frequently occur at multiple scales of observation.

Highly-sensitive and large-dynamic diffuse optical tomography system for breast tumor detection

NASA Astrophysics Data System (ADS)

Du, Wenwen; Zhang, Limin; Yin, Guoyan; Zhang, Yanqi; Zhao, Huijuan; Gao, Feng

2018-02-01

Diffuse optical tomography (DOT) as a new functional imaging has important clinical applications in many aspects such as benign and malignant breast tumor detection, tumor staging and so on. For quantitative detection of breast tumor, a three-wavelength continuous-wave DOT prototype system combined the ultra-high sensitivity of the photon-counting detection and the measurement parallelism of the lock-in technique was developed to provide high temporal resolution, high sensitivity, large dynamic detection range and signal-to-noise ratio. Additionally, a CT-analogous scanning mode was proposed to cost-effectively increase the detection data. To evaluate the feasibility of the system, a series of assessments were conducted. The results demonstrate that the system can obtain high linearity, stability and negligible inter-wavelength crosstalk. The preliminary phantom experiments show the absorption coefficient is able to be successfully reconstructed, indicating that the system is one of the ideal platforms for optical breast tumor detection.

High-resolution harmonic motion imaging (HR-HMI) for tissue biomechanical property characterization.

PubMed

Ma, Teng; Qian, Xuejun; Chiu, Chi Tat; Yu, Mingyue; Jung, Hayong; Tung, Yao-Sheng; Shung, K Kirk; Zhou, Qifa

2015-02-01

Elastography, capable of mapping the biomechanical properties of biological tissues, serves as a useful technique for clinicians to perform disease diagnosis and determine stages of many diseases. Many acoustic radiation force (ARF) based elastography, including acoustic radiation force impulse (ARFI) imaging and harmonic motion imaging (HMI), have been developed to remotely assess the elastic properties of tissues. However, due to the lower operating frequencies of these approaches, their spatial resolutions are insufficient for revealing stiffness distribution on small scale applications, such as cancerous tumor margin detection, atherosclerotic plaque composition analysis and ophthalmologic tissue characterization. Though recently developed ARF-based optical coherence elastography (OCE) methods open a new window for the high resolution elastography, shallow imaging depths significantly limit their usefulness in clinics. The aim of this study is to develop a high-resolution HMI method to assess the tissue biomechanical properties with acceptable field of view (FOV) using a 4 MHz ring transducer for efficient excitation and a 40 MHz needle transducer for accurate detection. Under precise alignment of two confocal transducers, the high-resolution HMI system has a lateral resolution of 314 µm and an axial resolution of 
147 µm with an effective FOV of 2 mm in depth. The performance of this high resolution imaging system was validated on the agar-based tissue mimicking phantoms with different stiffness distributions. These data demonstrated the imaging system's improved resolution and sensitivity on differentiating materials with varying stiffness. In addition, ex vivo imaging of a human atherosclerosis coronary artery demonstrated the capability of high resolution HMI in identifying layer-specific structures and characterizing atherosclerotic plaques based on their stiffness differences. All together high resolution HMI appears to be a promising ultrasound-only technology for characterizing tissue biomechanical properties at the microstructural level to improve the image-based diseases diagnosis in multiple clinical applications.

A long-time, high spatiotemporal resolution optical recording system for membrane potential activity via real-time writing to the hard disk.

PubMed

Hirota, Akihiko; Ito, Shin-ichi

2006-06-01

Using real-time hard disk recording, we have developed an optical system for the long-duration detection of changes in membrane potential from 1,020 sites with a high temporal resolution. The signal-to-noise ratio was sufficient for analyzing the spreading pattern of excitatory waves in frog atria in a single sweep.

Note: An improved 3D imaging system for electron-electron coincidence measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lin, Yun Fei; Lee, Suk Kyoung; Adhikari, Pradip

We demonstrate an improved imaging system that can achieve highly efficient 3D detection of two electrons in coincidence. The imaging system is based on a fast frame complementary metal-oxide semiconductor camera and a high-speed waveform digitizer. We have shown previously that this detection system is capable of 3D detection of ions and electrons with good temporal and spatial resolution. Here, we show that with a new timing analysis algorithm, this system can achieve an unprecedented dead-time (<0.7 ns) and dead-space (<1 mm) when detecting two electrons. A true zero dead-time detection is also demonstrated.

Note: An improved 3D imaging system for electron-electron coincidence measurements

NASA Astrophysics Data System (ADS)

Lin, Yun Fei; Lee, Suk Kyoung; Adhikari, Pradip; Herath, Thushani; Lingenfelter, Steven; Winney, Alexander H.; Li, Wen

2015-09-01

We demonstrate an improved imaging system that can achieve highly efficient 3D detection of two electrons in coincidence. The imaging system is based on a fast frame complementary metal-oxide semiconductor camera and a high-speed waveform digitizer. We have shown previously that this detection system is capable of 3D detection of ions and electrons with good temporal and spatial resolution. Here, we show that with a new timing analysis algorithm, this system can achieve an unprecedented dead-time (<0.7 ns) and dead-space (<1 mm) when detecting two electrons. A true zero dead-time detection is also demonstrated.

A concept for early cancer detection and therapy

NASA Astrophysics Data System (ADS)

Waynant, Ronald W.; Ilev, Ilko K.; Mitra, Kunal

2003-06-01

Early detection and treatment of breast cancer is least costly in terms of dollars, morbidity and mortality. With new early detection x-ray technology, tumors can be found, diagnosed and treated at a much smaller size than is currently possible. This paper proposes the development of a high resolution, high quality imaging system. It is a laser-driven x-ray system with time-gated detection that removes scattering noise in the image and produces resolution on the order of 10 μm. This higher resolution and higher image quality will enable the detection of one or two millimeter tumors hopefully detecting them before metastasis. We also propose that tumor detection should be followed by an immediate needle-directed, optical fiber biopsy to instantly determine if cancer is present and, if present, the tumor should immediately be given a lethal treatment of laser or x-radiation through the same needle using fiber optics or hollow waveguides. This technology will help prevent multiple interventions resulting in both the lowest overall cost and a more efficacious therapy. The approach can be stopped at the first negative (benign) indication and will help forestall repeated examination as well as reduce patient anxiety.

Ultra High-Resolution Electrospray Ionization/Ion Mobility Spectrometer System for In-Situ Detection of Organic Compounds

NASA Technical Reports Server (NTRS)

Kanik, I.; Beegle, L. W.; Hill, H. H.

2001-01-01

The potential of the high-resolution Electrospray Ionization/Ion Mobility Spectrometry (ESI/IMS) technique as analytical separation tool in analyzing bio-molecular mixtures in the search for the chemical signatures of life is demonstrated. Additional information is contained in the original extended abstract.

Land use change detection based on multi-date imagery from different satellite sensor systems

NASA Technical Reports Server (NTRS)

Stow, Douglas A.; Collins, Doretta; Mckinsey, David

1990-01-01

An empirical study is conducted to assess the accuracy of land use change detection using satellite image data acquired ten years apart by sensors with differing spatial resolutions. The primary goals of the investigation were to (1) compare standard change detection methods applied to image data of varying spatial resolution, (2) assess whether to transform the raster grid of the higher resolution image data to that of the lower resolution raster grid or vice versa in the registration process, (3) determine if Landsat/Thermatic Mapper or SPOT/High Resolution Visible multispectral data provide more accurate detection of land use changes when registered to historical Landsat/MSS data. It is concluded that image ratioing of multisensor, multidate satellite data produced higher change detection accuracies than did principal components analysis, and that it is useful as a land use change enhancement method.

A ultra-small-angle self-mixing sensor system with high detection resolution and wide measurement range

NASA Astrophysics Data System (ADS)

Yang, Bo; Wang, Dehui; Zhou, Lin; Wu, Shuang; Xiang, Rong; Zhang, Wenhua; Gui, Huaqiao; Liu, Jianguo; Wang, Huanqing; Lu, Liang; Yu, Benli

2017-06-01

The self-mixing technique based on the traditional reflecting mirror has been demonstrated with great merit for angle sensing applications. Here we demonstrate a modified self-reflection-mixing angle measurement system by combine a right-angle prism to self-mixing angle measurement. In our system, the wavelength is crucial to the angle measurement resolution. For a microchip solid-state laser, the measurement resolution can reach 0.49 mrad, while the resolution for the He-Ne laser is 0.53 mrad. In addition, the ranges in the system with the microchip solid-state laser and He-Ne laser are up to 22 mrad and 24.9 mrad respectively. This modified angle measurement system effectively combines the advantage of self-mixing measurement system with a compact structure, providing interesting features such as of high requisition of resolution and precision.

Handheld microwave bomb-detecting imaging system

NASA Astrophysics Data System (ADS)

Gorwara, Ashok; Molchanov, Pavlo

2017-05-01

Proposed novel imaging technique will provide all weather high-resolution imaging and recognition capability for RF/Microwave signals with good penetration through highly scattered media: fog, snow, dust, smoke, even foliage, camouflage, walls and ground. Image resolution in proposed imaging system is not limited by diffraction and will be determined by processor and sampling frequency. Proposed imaging system can simultaneously cover wide field of view, detect multiple targets and can be multi-frequency, multi-function. Directional antennas in imaging system can be close positioned and installed in cell phone size handheld device, on small aircraft or distributed around protected border or object. Non-scanning monopulse system allows dramatically decrease in transmitting power and at the same time provides increased imaging range by integrating 2-3 orders more signals than regular scanning imaging systems.

Comparison between two time-resolved approaches for prostate cancer diagnosis: high rate imager vs. photon counting system

NASA Astrophysics Data System (ADS)

Boutet, J.; Debourdeau, M.; Laidevant, A.; Hervé, L.; Dinten, J.-M.

2010-02-01

Finding a way to combine ultrasound and fluorescence optical imaging on an endorectal probe may improve early detection of prostate cancer. A trans-rectal probe adapted to fluorescence diffuse optical tomography measurements was developed by our team. This probe is based on a pulsed NIR laser source, an optical fiber network and a time-resolved detection system. A reconstruction algorithm was used to help locate and quantify fluorescent prostate tumors. In this study, two different kinds of time-resolved detectors are compared: High Rate Imaging system (HRI) and a photon counting system. The HRI is based on an intensified multichannel plate and a CCD Camera. The temporal resolution is obtained through a gating of the HRI. Despite a low temporal resolution (300ps), this system allows a simultaneous acquisition of the signal from a large number of detection fibers. In the photon counting setup, 4 photomultipliers are connected to a Time Correlated Single Photon Counting (TCSPC) board, providing a better temporal resolution (0.1 ps) at the expense of a limited number of detection fibers (4). At last, we show that the limited number of detection fibers of the photon counting setup is enough for a good localization and dramatically improves the overall acquisition time. The photon counting approach is then validated through the localization of fluorescent inclusions in a prostate-mimicking phantom.

CNV detection method optimized for high-resolution arrayCGH by normality test.

PubMed

Ahn, Jaegyoon; Yoon, Youngmi; Park, Chihyun; Park, Sanghyun

2012-04-01

High-resolution arrayCGH platform makes it possible to detect small gains and losses which previously could not be measured. However, current CNV detection tools fitted to early low-resolution data are not applicable to larger high-resolution data. When CNV detection tools are applied to high-resolution data, they suffer from high false-positives, which increases validation cost. Existing CNV detection tools also require optimal parameter values. In most cases, obtaining these values is a difficult task. This study developed a CNV detection algorithm that is optimized for high-resolution arrayCGH data. This tool operates up to 1500 times faster than existing tools on a high-resolution arrayCGH of whole human chromosomes which has 42 million probes whose average length is 50 bases, while preserving false positive/negative rates. The algorithm also uses a normality test, thereby removing the need for optimal parameters. To our knowledge, this is the first formulation for CNV detecting problems that results in a near-linear empirical overall complexity for real high-resolution data. Copyright © 2012 Elsevier Ltd. All rights reserved.

Principle, system, and applications of tip-enhanced Raman spectroscopy

NASA Astrophysics Data System (ADS)

Zhang, MingQian; Wang, Rui; Wu, XiaoBin; Wang, Jia

2012-08-01

Raman spectroscopy is a powerful technique in chemical information characterization. However, this spectral method is subject to two obstacles in nano-material detection. One is diffraction limited spatial resolution, and the other is its inherent small Raman cross section and weak signaling. To resolve these problems, a new approach has been developed, denoted as tip-enhanced Raman spectroscopy (TERS). TERS is capable of high-resolution and high-sensitivity detection and demonstrated to be a promising spectroscopic and micro-topographic method to characterize nano-materials and nanostructures. In this paper, the principle and experimental system of TERS are discussed. The latest application of TERS in molecule detection, biological specimen identification, nanao-material characterization, and semi-conductor material determination with some specific experimental examples are presented.

The Subaru Coronagraphic Extreme AO project: an XAO4ELT precursor

NASA Astrophysics Data System (ADS)

Martinache, F.

2011-09-01

A diffraction-limited 30-meter telescope theoretically provides a 10 mas resolution limit in the near infrared. Modern coronagraphs like the Vortex, the 8OPM and the PIAA offer the means to take full advantage of this angular resolution allowing to explore at high contrast, the innermost parts of nearby planetary systems to within a fraction of an astronomical unit: an unprecedented capability that will revolutionize our understanding of planet formation across the habitable zone. A precursor of such a system is the Subaru Coronagraphic Extreme AO project. SCExAO combines a high performance PIAA-based coronagraph downstream Subaru's AO188 AO system and a 1024-actuator MEMS DM. SCExAO employs advanced wavefront control schemes that make high contrast detection possible at 1 λ/D, providing for a few cases, the possibility to detect the light reflected by exoplanets. Moderate-high contrast detection in the super-resolution regime (<λ/D) is also possible using well calibrated closure quantities like closure-phase for a non-redundant (masked) aperture and its extension for to arbitrary apertures (Kernel-phase). Lessons learned from SCExAO's incremental deployment plan during its first 2011 engineering campaign provides insights that will guide future development of high contrast instrumentation on an ELT.

Assessing the impacts of canopy openness and flight parameters on detecting a sub-canopy tropical invasive plant using a small unmanned aerial system

NASA Astrophysics Data System (ADS)

Perroy, Ryan L.; Sullivan, Timo; Stephenson, Nathan

2017-03-01

Small unmanned aerial systems (sUAS) have great potential to facilitate the early detection and management of invasive plants. Here we show how very high-resolution optical imagery, collected from small consumer-grade multirotor UAS platform at altitudes of 30-120 m above ground level (agl), can be used to detect individual miconia (Miconia calvescens) plants in a highly invaded tropical rainforest environment on the island of Hawai'i. The central aim of this research was to determine how overstory vegetation cover, imagery resolution, and camera look-angle impact the aerial detection of known individual miconia plants. For our finest resolution imagery (1.37 cm ground sampling distance collected at 30 m agl), we obtained a 100% detection rate for sub-canopy plants with above-crown openness values >40% and a 69% detection rate for those with >20% openness. We were unable to detect any plants with <10% above crown openness. Detection rates progressively declined with coarser spatial resolution imagery, ending in a 0% detection rate for the 120 m agl flights (ground sampling distance of 5.31 cm). The addition of forward-looking oblique imagery improved detection rates for plants below overstory vegetation, though this effect decreased with increasing flight altitude. While dense overstory canopy cover, limited flight times, and visual line of sight regulations present formidable obstacles for detecting miconia and other invasive plant species, we show that sUAS platforms carrying optical sensors can be an effective component of an integrated management plan within challenging subcanopy forest environments.

Developments on a SEM-based X-ray tomography system: Stabilization scheme and performance evaluation

NASA Astrophysics Data System (ADS)

Gomes Perini, L. A.; Bleuet, P.; Filevich, J.; Parker, W.; Buijsse, B.; Kwakman, L. F. Tz.

2017-06-01

Recent improvements in a SEM-based X-ray tomography system are described. In this type of equipment, X-rays are generated through the interaction between a highly focused electron-beam and a geometrically confined anode target. Unwanted long-term drifts of the e-beam can lead to loss of X-ray flux or decrease of spatial resolution in images. To circumvent this issue, a closed-loop control using FFT-based image correlation is integrated to the acquisition routine, in order to provide an in-line drift correction. The X-ray detection system consists of a state-of-the-art scientific CMOS camera (indirect detection), featuring high quantum efficiency (˜60%) and low read-out noise (˜1.2 electrons). The system performance is evaluated in terms of resolution, detectability, and scanning times for applications covering three different scientific fields: microelectronics, technical textile, and material science.

Detecting personnel around UGVs using stereo vision

NASA Astrophysics Data System (ADS)

Bajracharya, Max; Moghaddam, Baback; Howard, Andrew; Matthies, Larry H.

2008-04-01

Detecting people around unmanned ground vehicles (UGVs) to facilitate safe operation of UGVs is one of the highest priority issues in the development of perception technology for autonomous navigation. Research to date has not achieved the detection ranges or reliability needed in deployed systems to detect upright pedestrians in flat, relatively uncluttered terrain, let alone in more complex environments and with people in postures that are more difficult to detect. Range data is essential to solve this problem. Combining range data with high resolution imagery may enable higher performance than range data alone because image appearance can complement shape information in range data and because cameras may offer higher angular resolution than typical range sensors. This makes stereo vision a promising approach for several reasons: image resolution is high and will continue to increase, the physical size and power dissipation of the cameras and computers will continue to decrease, and stereo cameras provide range data and imagery that are automatically spatially and temporally registered. We describe a stereo vision-based pedestrian detection system, focusing on recent improvements to a shape-based classifier applied to the range data, and present frame-level performance results that show great promise for the overall approach.

Sensor fusion to enable next generation low cost Night Vision systems

NASA Astrophysics Data System (ADS)

Schweiger, R.; Franz, S.; Löhlein, O.; Ritter, W.; Källhammer, J.-E.; Franks, J.; Krekels, T.

2010-04-01

The next generation of automotive Night Vision Enhancement systems offers automatic pedestrian recognition with a performance beyond current Night Vision systems at a lower cost. This will allow high market penetration, covering the luxury as well as compact car segments. Improved performance can be achieved by fusing a Far Infrared (FIR) sensor with a Near Infrared (NIR) sensor. However, fusing with today's FIR systems will be too costly to get a high market penetration. The main cost drivers of the FIR system are its resolution and its sensitivity. Sensor cost is largely determined by sensor die size. Fewer and smaller pixels will reduce die size but also resolution and sensitivity. Sensitivity limits are mainly determined by inclement weather performance. Sensitivity requirements should be matched to the possibilities of low cost FIR optics, especially implications of molding of highly complex optical surfaces. As a FIR sensor specified for fusion can have lower resolution as well as lower sensitivity, fusing FIR and NIR can solve performance and cost problems. To allow compensation of FIR-sensor degradation on the pedestrian detection capabilities, a fusion approach called MultiSensorBoosting is presented that produces a classifier holding highly discriminative sub-pixel features from both sensors at once. The algorithm is applied on data with different resolution and on data obtained from cameras with varying optics to incorporate various sensor sensitivities. As it is not feasible to record representative data with all different sensor configurations, transformation routines on existing high resolution data recorded with high sensitivity cameras are investigated in order to determine the effects of lower resolution and lower sensitivity to the overall detection performance. This paper also gives an overview of the first results showing that a reduction of FIR sensor resolution can be compensated using fusion techniques and a reduction of sensitivity can be compensated.

Resolution-improved in situ DNA hybridization detection based on microwave photonic interrogation.

PubMed

Cao, Yuan; Guo, Tuan; Wang, Xudong; Sun, Dandan; Ran, Yang; Feng, Xinhuan; Guan, Bai-ou

2015-10-19

In situ bio-sensing system based on microwave photonics filter (MPF) interrogation method with improved resolution is proposed and experimentally demonstrated. A microfiber Bragg grating (mFBG) is used as sensing probe for DNA hybridization detection. Different from the traditional wavelength monitoring technique, we use the frequency interrogation scheme for resolution-improved bio-sensing detection. Experimental results show that the frequency shift of MPF notch presents a linear response to the surrounding refractive index (SRI) change over the range of 1.33 to 1.38, with a SRI resolution up to 2.6 × 10(-5) RIU, which has been increased for almost two orders of magnitude compared with the traditional fundamental mode monitoring technique (~3.6 × 10(-3) RIU). Due to the high Q value (about 27), the whole process of DNA hybridization can be in situ monitored. The proposed MPF-based bio-sensing system provides a new interrogation method over the frequency domain with improved sensing resolution and rapid interrogation rate for biochemical and environmental measurement.

Thermal infrared panoramic imaging sensor

NASA Astrophysics Data System (ADS)

Gutin, Mikhail; Tsui, Eddy K.; Gutin, Olga; Wang, Xu-Ming; Gutin, Alexey

2006-05-01

Panoramic cameras offer true real-time, 360-degree coverage of the surrounding area, valuable for a variety of defense and security applications, including force protection, asset protection, asset control, security including port security, perimeter security, video surveillance, border control, airport security, coastguard operations, search and rescue, intrusion detection, and many others. Automatic detection, location, and tracking of targets outside protected area ensures maximum protection and at the same time reduces the workload on personnel, increases reliability and confidence of target detection, and enables both man-in-the-loop and fully automated system operation. Thermal imaging provides the benefits of all-weather, 24-hour day/night operation with no downtime. In addition, thermal signatures of different target types facilitate better classification, beyond the limits set by camera's spatial resolution. The useful range of catadioptric panoramic cameras is affected by their limited resolution. In many existing systems the resolution is optics-limited. Reflectors customarily used in catadioptric imagers introduce aberrations that may become significant at large camera apertures, such as required in low-light and thermal imaging. Advantages of panoramic imagers with high image resolution include increased area coverage with fewer cameras, instantaneous full horizon detection, location and tracking of multiple targets simultaneously, extended range, and others. The Automatic Panoramic Thermal Integrated Sensor (APTIS), being jointly developed by Applied Science Innovative, Inc. (ASI) and the Armament Research, Development and Engineering Center (ARDEC) combines the strengths of improved, high-resolution panoramic optics with thermal imaging in the 8 - 14 micron spectral range, leveraged by intelligent video processing for automated detection, location, and tracking of moving targets. The work in progress supports the Future Combat Systems (FCS) and the Intelligent Munitions Systems (IMS). The APTIS is anticipated to operate as an intelligent node in a wireless network of multifunctional nodes that work together to serve in a wide range of applications of homeland security, as well as serve the Army in tasks of improved situational awareness (SA) in defense and offensive operations, and as a sensor node in tactical Intelligence Surveillance Reconnaissance (ISR). The novel ViperView TM high-resolution panoramic thermal imager is the heart of the APTIS system. It features an aberration-corrected omnidirectional imager with small optics designed to match the resolution of a 640x480 pixels IR camera with improved image quality for longer range target detection, classification, and tracking. The same approach is applicable to panoramic cameras working in the visible spectral range. Other components of the ATPIS system include network communications, advanced power management, and wakeup capability. Recent developments include image processing, optical design being expanded into the visible spectral range, and wireless communications design. This paper describes the development status of the APTIS system.

Imaging of cellular spread on a three-dimensional scaffold by means of a novel cell-labeling technique for high-resolution computed tomography.

PubMed

Thimm, Benjamin W; Hofmann, Sandra; Schneider, Philipp; Carretta, Roberto; Müller, Ralph

2012-03-01

Computed tomography (CT) represents a truly three-dimensional (3D) imaging technique that can provide high-resolution images on the cellular level. Thus, one approach to detect single cells is X-ray absorption-based CT, where cells are labeled with a dense, opaque material providing the required contrast for CT imaging. Within the present work, a novel cell-labeling method has been developed showing the feasibility of labeling fixed cells with iron oxide (FeO) particles for subsequent CT imaging and quantitative morphometry. A biotin-streptavidin detection system was exploited to bind FeO particles to its target endothelial cells. The binding of the particles was predominantly close to the cell centers on 2D surfaces as shown by light microscopy, scanning electron microscopy, and CT. When cells were cultured on porous, 3D polyurethane surfaces, significantly more FeO particles were detected compared with surfaces without cells and FeO particle labeling using CT. Here, we report on the implementation and evaluation of a novel cell detection method based on high-resolution CT. This system has potential in cell tracking for 3D in vitro imaging in the future.

Peripheral detection and resolution with mid-/long-wavelength and short-wavelength sensitive cone systems.

PubMed

Zhu, Hai-Feng; Zele, Andrew J; Suheimat, Marwan; Lambert, Andrew J; Atchison, David A

2016-08-01

This study compared neural resolution and detection limits of the human mid-/long-wavelength and short-wavelength cone systems with anatomical estimates of photoreceptor and retinal ganglion cell spacings and sizes. Detection and resolution limits were measured from central fixation out to 35° eccentricity across the horizontal visual field using a modified Lotmar interferometer. The mid-/long-wavelength cone system was studied using a green (550 nm) test stimulus to which S-cones have low sensitivity. To bias resolution and detection to the short-wavelength cone system, a blue (450 nm) test stimulus was presented against a bright yellow background that desensitized the M- and L-cones. Participants were three trichromatic males with normal visual functions. With green stimuli, resolution showed a steep central-peripheral gradient that was similar between participants, whereas the detection gradient was shallower and patterns were different between participants. Detection and resolution with blue stimuli were poorer than for green stimuli. The detection of blue stimuli was superior to resolution across the horizontal visual field and the patterns were different between participants. The mid-/long-wavelength cone system's resolution is limited by midget ganglion cell spacing and its detection is limited by the size of the M- and L-cone photoreceptors, consistent with previous observations. We found that no such simple relationships occur for the short-wavelength cone system between resolution and the bistratified ganglion cell spacing, nor between detection and the S-cone photoreceptor sizes.

Near-infrared high-resolution real-time omnidirectional imaging platform for drone detection

NASA Astrophysics Data System (ADS)

Popovic, Vladan; Ott, Beat; Wellig, Peter; Leblebici, Yusuf

2016-10-01

Recent technological advancements in hardware systems have made higher quality cameras. State of the art panoramic systems use them to produce videos with a resolution of 9000 x 2400 pixels at a rate of 30 frames per second (fps).1 Many modern applications use object tracking to determine the speed and the path taken by each object moving through a scene. The detection requires detailed pixel analysis between two frames. In fields like surveillance systems or crowd analysis, this must be achieved in real time.2 In this paper, we focus on the system-level design of multi-camera sensor acquiring near-infrared (NIR) spectrum and its ability to detect mini-UAVs in a representative rural Swiss environment. The presented results show the UAV detection from the trial that we conducted during a field trial in August 2015.

Analysis system of submicron particle tracks in the fine-grained nuclear emulsion by a combination of hard x-ray and optical microscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Naka, T., E-mail: naka@flab.phys.nagoya-u.ac.jp; Institute for Advanced Research, Nagoya University, Aichi 464-8602; Asada, T.

Analyses of nuclear emulsion detectors that can detect and identify charged particles or radiation as tracks have typically utilized optical microscope systems because the targets have lengths from several μm to more than 1000 μm. For recent new nuclear emulsion detectors that can detect tracks of submicron length or less, the current readout systems are insufficient due to their poor resolution. In this study, we developed a new system and method using an optical microscope system for rough candidate selection and the hard X-ray microscope system at SPring-8 for high-precision analysis with a resolution of better than 70 nm resolution.more » Furthermore, we demonstrated the analysis of submicron-length tracks with a matching efficiency of more than 99% and position accuracy of better than 5 μm. This system is now running semi-automatically.« less

Detecting metastasis of gastric carcinoma using high-resolution micro-CT system: in vivo small animal study

NASA Astrophysics Data System (ADS)

Liu, Junting; Tian, Jie; Liang, Jimin; Li, Xiangsi; Yang, Xiang; Chen, Xiaofeng; Chen, Yi; Zhou, Yuanfang; Wang, Xiaorui

2011-03-01

Immunocytochemical and immunofluorescence staining are used for identifying the characteristics of metastasis in traditional ways. Micro-computed tomography (micro-CT) is a useful tool for monitoring and longitudinal imaging of tumor in small animal in vivo. In present study, we evaluated the feasibility of the detection for metastasis of gastric carcinoma by high-resolution micro-CT system with omnipaque accumulative enhancement method in the organs. Firstly, a high-resolution micro-CT ZKKS-MCT-sharp micro-CT was developed by our research group and Guangzhou Zhongke Kaisheng Medical Technology Co., Ltd. Secondly, several gastric carcinoma models were established through inoculating 2x106 BGC-823 gastric carcinoma cells subcutaneously. Thirdly, micro-CT scanning was performed after accumulative enhancement method of intraperitoneal injection of omnipaque contrast agent containing 360 mg iodine with a concentration of 350 mg I/ml. Finally, we obtained high-resolution anatomical information of the metastasis in vivo in a BALB/c NuNu nude mouse, the 3D tumor architecture is revealed in exquisite detail at about 35 μm spatial resolution. In addition, the accurate shape and volume of the micrometastasis as small as 0.78 mm3 can be calculated with our software. Overall, our data suggest that this imaging approach and system could be used to enhance the understanding of tumor proliferation, metastasis and could be the basis for evaluating anti-tumor therapies.

Ultrahigh resolution optical coherence elastography using a Bessel beam for extended depth of field

NASA Astrophysics Data System (ADS)

Curatolo, Andrea; Villiger, Martin; Lorenser, Dirk; Wijesinghe, Philip; Fritz, Alexander; Kennedy, Brendan F.; Sampson, David D.

2016-03-01

Visualizing stiffness within the local tissue environment at the cellular and sub-cellular level promises to provide insight into the genesis and progression of disease. In this paper, we propose ultrahigh-resolution optical coherence elastography, and demonstrate three-dimensional imaging of local axial strain of tissues undergoing compressive loading. The technique employs a dual-arm extended focus optical coherence microscope to measure tissue displacement under compression. The system uses a broad bandwidth supercontinuum source for ultrahigh axial resolution, Bessel beam illumination and Gaussian beam detection, maintaining sub-2 μm transverse resolution over nearly 100 μm depth of field, and spectral-domain detection allowing high displacement sensitivity. The system produces strain elastograms with a record resolution (x,y,z) of 2×2×15 μm. We benchmark the advances in terms of resolution and strain sensitivity by imaging a suitable inclusion phantom. We also demonstrate this performance on freshly excised mouse aorta and reveal the mechanical heterogeneity of vascular smooth muscle cells and elastin sheets, otherwise unresolved in a typical, lower resolution optical coherence elastography system.

T85C polymorphisms of the dihydropyrimidine dehydrogenase gene detected in gastric cancer tissues by high-resolution melting curve analysis.

PubMed

Fang, Weijia; Xu, Nong; Jin, Dazhi; Chen, Yu; Chen, Xiaogang; Zheng, Yi; Shen, Hong; Yuan, Ying; Zheng, Shusen

2012-01-01

Dihydropyrimidine dehydrogenase is a key enzyme acting on the metabolic pathway of medications for gastric cancer. High-resolution melting curve technology, which was developed recently, can distinguish the wild-type dihydropyrimidine dehydrogenase gene from multiple polymorphisms by fluorescent quantitative polymerase chain reaction products in a direct and effective manner. T85C polymorphisms of dihydropyrimidine dehydrogenase in the peripheral blood of 112 Chinese gastric cancer patients were detected by real-time polymerase chain reaction combined with high-resolution melting curve technology. Primer design, along with the reaction system and conditions, was optimized based on the GenBank sequence. Seventy nine cases of wild-type (TT, [70.5%]), 29 cases of heterozygous (TC, [25.9%]), and 4 cases of homozygous mutant (CC, [3.6%]) were observed. The result was completely consistent with the results of the sequencing. Real-time polymerase chain reaction combined with high-resolution melting curve technology is a rapid, simple, reliable, direct-viewing, and convenient method for the detection and screening of polymorphisms.

Ultra high spatial and temporal resolution breast imaging at 7T.

PubMed

van de Bank, B L; Voogt, I J; Italiaander, M; Stehouwer, B L; Boer, V O; Luijten, P R; Klomp, D W J

2013-04-01

There is a need to obtain higher specificity in the detection of breast lesions using MRI. To address this need, Dynamic Contrast-Enhanced (DCE) MRI has been combined with other structural and functional MRI techniques. Unfortunately, owing to time constraints structural images at ultra-high spatial resolution can generally not be obtained during contrast uptake, whereas the relatively low spatial resolution of functional imaging (e.g. diffusion and perfusion) limits the detection of small lesions. To be able to increase spatial as well as temporal resolution simultaneously, the sensitivity of MR detection needs to increase as well as the ability to effectively accelerate the acquisition. The required gain in signal-to-noise ratio (SNR) can be obtained at 7T, whereas acceleration can be obtained with high-density receiver coil arrays. In this case, morphological imaging can be merged with DCE-MRI, and other functional techniques can be obtained at higher spatial resolution, and with less distortion [e.g. Diffusion Weighted Imaging (DWI)]. To test the feasibility of this concept, we developed a unilateral breast coil for 7T. It comprises a volume optimized dual-channel transmit coil combined with a 30-channel receive array coil. The high density of small coil elements enabled efficient acceleration in any direction to acquire ultra high spatial resolution MRI of close to 0.6 mm isotropic detail within a temporal resolution of 69 s, high spatial resolution MRI of 1.5 mm isotropic within an ultra high temporal resolution of 6.7 s and low distortion DWI at 7T, all validated in phantoms, healthy volunteers and a patient with a lesion in the right breast classified as Breast Imaging Reporting and Data System (BI-RADS) IV. Copyright © 2012 John Wiley & Sons, Ltd.

Traffic Sign Recognition with Invariance to Lighting in Dual-Focal Active Camera System

NASA Astrophysics Data System (ADS)

Gu, Yanlei; Panahpour Tehrani, Mehrdad; Yendo, Tomohiro; Fujii, Toshiaki; Tanimoto, Masayuki

In this paper, we present an automatic vision-based traffic sign recognition system, which can detect and classify traffic signs at long distance under different lighting conditions. To realize this purpose, the traffic sign recognition is developed in an originally proposed dual-focal active camera system. In this system, a telephoto camera is equipped as an assistant of a wide angle camera. The telephoto camera can capture a high accuracy image for an object of interest in the view field of the wide angle camera. The image from the telephoto camera provides enough information for recognition when the accuracy of traffic sign is low from the wide angle camera. In the proposed system, the traffic sign detection and classification are processed separately for different images from the wide angle camera and telephoto camera. Besides, in order to detect traffic sign from complex background in different lighting conditions, we propose a type of color transformation which is invariant to light changing. This color transformation is conducted to highlight the pattern of traffic signs by reducing the complexity of background. Based on the color transformation, a multi-resolution detector with cascade mode is trained and used to locate traffic signs at low resolution in the image from the wide angle camera. After detection, the system actively captures a high accuracy image of each detected traffic sign by controlling the direction and exposure time of the telephoto camera based on the information from the wide angle camera. Moreover, in classification, a hierarchical classifier is constructed and used to recognize the detected traffic signs in the high accuracy image from the telephoto camera. Finally, based on the proposed system, a set of experiments in the domain of traffic sign recognition is presented. The experimental results demonstrate that the proposed system can effectively recognize traffic signs at low resolution in different lighting conditions.

A fiber air-gap Fabry-Pérot temperature sensor demodulated by using frequency modulated continuous wave

NASA Astrophysics Data System (ADS)

Zheng, Wanfu; Xie, Jianglei; Li, Yi; Xu, Ben; Kang, Juan; Shen, Changyu; Wang, Jianfeng; Jin, Yongxing; Liu, Honglin; Ni, Kai; Dong, Xinyong; Zhao, Chunliu; Jin, Shangzhong

In this study, a fiber in-line air-gap Fabry-Pérot interferometer (FPI) is fabricated by HF acid etching. For a low-cost and higher precise measurement, a demodulation system based on frequency modulated continuous wave (FMCW) technique is build up and demonstrated in this air-gap FPI. In temperature measurements, the temperature sensitivity is about 1.75 rad/°C by phase shift detection. We also test the long term performance of the system and the RMS error is about 0.04 rad, which corresponds to the temperature resolution of ~0.02 °C. It is much higher than the measurement resolution by using the traditional wavelength shift detection method. Our experiments show that the FMCW can provide a low-cost, high resolution and high speed interrogation solution to the fiber FPIs.

High-rate x-ray spectroscopy in mammography with a CdTe detector: a digital pulse processing approach.

PubMed

Abbene, L; Gerardi, G; Principato, F; Del Sordo, S; Ienzi, R; Raso, G

2010-12-01

Direct measurement of mammographic x-ray spectra under clinical conditions is a difficult task due to the high fluence rate of the x-ray beams as well as the limits in the development of high resolution detection systems in a high counting rate environment. In this work we present a detection system, based on a CdTe detector and an innovative digital pulse processing (DPP) system, for high-rate x-ray spectroscopy in mammography. The DPP system performs a digital pile-up inspection and a digital pulse height analysis of the detector signals, digitized through a 14-bit, 100 MHz digitizer, for x-ray spectroscopy even at high photon counting rates. We investigated on the response of the digital detection system both at low (150 cps) and at high photon counting rates (up to 500 kcps) by using monoenergetic x-ray sources and a nonclinical molybdenum anode x-ray tube. Clinical molybdenum x-ray spectrum measurements were also performed by using a pinhole collimator and a custom alignment device. The detection system shows excellent performance up to 512 kcps with an energy resolution of 4.08% FWHM at 22.1 keV. Despite the high photon counting rate (up to 453 kcps), the molybdenum x-ray spectra, measured under clinical conditions, are characterized by a low number of pile-up events. The agreement between the attenuation curves and the half value layer values, obtained from the measured spectra, simulated spectra, and from the exposure values directly measured with an ionization chamber, also shows the accuracy of the measurements. These results make the proposed detection system a very attractive tool for both laboratory research and advanced quality controls in mammography.

A Novel SPM Probe with MOS Transistor and Nano Tip for Surface Electric Properties

NASA Astrophysics Data System (ADS)

Lee, Sang H.; Lim, Geunbae; Moon, Wonkyu

2007-03-01

In this paper, the novel SPM (Scanning Probe Microscope) probe with the planar MOS (Metal-Oxide-Semiconductor) transistor and the FIB (Focused Ion Beam) nano tip is fabricated for the surface electric properties. Since the MOS transistor has high working frequency, the device can overcome the speed limitation of EFM (Electrostatic Force Microscope) system. The sensitivity is also high, and no bulky device such as lock-in-amplifier is required. Moreover, the nano tip with nanometer scale tip radius is fabricated with FIB system, and the resolution can be improved. Therefore, the probe can rapidly detect small localized electric properties with high sensitivity and high resolution. The MOS transistor is fabricated with the common semiconductor process, and the nano tip is grown by the FIB system. The planar structure of the MOS transistor makes the fabrication process easier, which is the advantage on the commercial production. Various electric signals are applied using the function generator, and the measured data represent the well-established electric properties of the device. It shows the promising aspect of the local surface electric property detection with high sensitivity and high resolution.

Demonstration of motionless Knudsen pump based micro-gas chromatography featuring micro-fabricated columns and on-column detectors.

PubMed

Liu, Jing; Gupta, Naveen K; Wise, Kensall D; Gianchandani, Yogesh B; Fan, Xudong

2011-10-21

This paper reports the investigation of a micro-gas chromatography (μGC) system that utilizes an array of miniaturized motionless Knudsen pumps (KPs) as well as microfabricated separation columns and optical detectors. A prototype system was built to achieve a flow rate of 1 mL min(-1) and 0.26 mL min(-1) for helium and dry air, respectively, when they were used as carrier gas. This system was then employed to evaluate GC performance compromises and demonstrate the ability to separate and detect gas mixtures containing analytes of different volatilities and polarities. Furthermore, the use of pressure programming of the KP array was demonstrated to significantly shorten the analysis time while maintaining a high detection resolution. Using this method, we obtained a high resolution detection of 5 alkanes of different volatilities within 5 min. Finally, we successfully detected gas mixtures of various polarities using a tandem-column μGC configuration by installing two on-column optical detectors to obtain complementary chromatograms.

New set of design rules for resonant refractive index sensors enabled by FFT based processing of the measurement data.

PubMed

Gounaridis, Lefteris; Groumas, Panos; Schreuder, Erik; Heideman, Rene; Avramopoulos, Hercules; Kouloumentas, Christos

2016-04-04

It is still a common belief that ultra-high quality-factors (Q-factors) are a prerequisite in optical resonant cavities for high refractive index resolution and low detection limit in biosensing applications. In combination with the ultra-short steps that are necessary when the measurement of the resonance shift relies on the wavelength scanning of a laser source and conventional methods for data processing, the high Q-factor requirement makes these biosensors extremely impractical. In this work we analyze an alternative processing method based on the fast-Fourier transform, and show through Monte-Carlo simulations that improvement by 2-3 orders of magnitude can be achieved in the resolution and the detection limit of the system in the presence of amplitude and spectral noise. More significantly, this improvement is maximum for low Q-factors around 10⁴ and is present also for high intra-cavity losses and large scanning steps making the designs compatible with the low-cost aspect of lab-on-a-chip technology. Using a micro-ring resonator as model cavity and a system design with low Q-factor (10⁴), low amplitude transmission (0.85) and relatively large scanning step (0.25 pm), we show that resolution close to 0.01 pm and detection limit close to 10^-7 RIU can be achieved improving the sensing performance by more than 2 orders of magnitude compared to the performance of systems relying on a simple peak search processing method. The improvement in the limit of detection is present even when the simple method is combined with ultra-high Q-factors and ultra-short scanning steps due to the trade-off between the system resolution and sensitivity. Early experimental results are in agreement with the trends of the numerical studies.

Change detection of polarimetric SAR images based on the KummerU Distribution

NASA Astrophysics Data System (ADS)

Chen, Quan; Zou, Pengfei; Li, Zhen; Zhang, Ping

2014-11-01

In the society of PolSAR image segmentation, change detection and classification, the classical Wishart distribution has been used for a long time, but it especially suit to low-resolution SAR image, because in traditional sensors, only a small number of scatterers are present in each resolution cell. With the improving of SAR systems these years, the classical statistical models can therefore be reconsidered for high resolution and polarimetric information contained in the images acquired by these advanced systems. In this study, SAR image segmentation algorithm based on level-set method, added with distance regularized level-set evolution (DRLSE) is performed using Envisat/ASAR single-polarization data and Radarsat-2 polarimetric images, respectively. KummerU heterogeneous clutter model is used in the later to overcome the homogeneous hypothesis at high resolution cell. An enhanced distance regularized level-set evolution (DRLSE-E) is also applied in the later, to ensure accurate computation and stable level-set evolution. Finally, change detection based on four polarimetric Radarsat-2 time series images is carried out at Genhe area of Inner Mongolia Autonomous Region, NorthEastern of China, where a heavy flood disaster occurred during the summer of 2013, result shows the recommend segmentation method can detect the change of watershed effectively.

Assessment of a vertical high-resolution distributed-temperature-sensing system in a shallow thermohaline environment

NASA Astrophysics Data System (ADS)

Suárez, F.; Aravena, J. E.; Hausner, M. B.; Childress, A. E.; Tyler, S. W.

2011-01-01

In shallow thermohaline-driven lakes it is important to measure temperature on fine spatial and temporal scales to detect stratification or different hydrodynamic regimes. Raman spectra distributed temperature sensing (DTS) is an approach available to provide high spatial and temporal temperature resolution. A vertical high-resolution DTS system was constructed to overcome the problems of typical methods used in the past, i.e., without disturbing the water column, and with resistance to corrosive environments. This system monitors the temperature profile each 1.1 cm vertically and in time averages as small as 10 s. Temperature resolution as low as 0.035 °C is obtained when the data are collected at 5-min intervals. The vertical high-resolution DTS system is used to monitor the thermal behavior of a salt-gradient solar pond, which is an engineered shallow thermohaline system that allows collection and storage of solar energy for a long period of time. This paper describes a method to quantitatively assess accuracy, precision and other limitations of DTS systems to fully utilize the capacity of this technology. It also presents, for the first time, a method to manually calibrate temperatures along the optical fiber.

High-sensitivity Leak-testing Method with High-Resolution Integration Technique

NASA Astrophysics Data System (ADS)

Fujiyoshi, Motohiro; Nonomura, Yutaka; Senda, Hidemi

A high-resolution leak-testing method named HR (High-Resolution) Integration Technique has been developed for MEMS (Micro Electro Mechanical Systems) sensors such as a vibrating angular-rate sensor housed in a vacuum package. Procedures of the method to obtain high leak-rate resolution were as follows. A package filled with helium gas was kept in a small accumulation chamber to accumulate helium gas leaking from the package. After the accumulation, the accumulated helium gas was introduced into a mass spectrometer in a short period of time, and the flux of the helium gas was measured by the mass spectrometer as a transient phenomenon. The leak-rate of the package was calculated from the detected transient waveform of the mass spectrometer and the accumulation time of the helium gas in the accumulation chamber. Because the density of the helium gas in the vacuum chamber increased and the accumulated helium gas was measured in a very short period of time with the mass spectrometer, the peak strength of the transient waveform became high and the signal to noise ratio was much improved. The detectable leak-rate resolution of the technique reached 1×10-15 (Pa·m3/s). This resolution is 103 times superior to that of the conventional helium vacuum integration method. The accuracy of the measuring system was verified with a standard helium gas leak source. The results were well matched between theoretical calculation based on the leak-rate of the source and the experimental results within only 2% error.

High-resolution harmonic motion imaging (HR-HMI) for tissue biomechanical property characterization

PubMed Central

Ma, Teng; Qian, Xuejun; Chiu, Chi Tat; Yu, Mingyue; Jung, Hayong; Tung, Yao-Sheng; Shung, K. Kirk

2015-01-01

Background Elastography, capable of mapping the biomechanical properties of biological tissues, serves as a useful technique for clinicians to perform disease diagnosis and determine stages of many diseases. Many acoustic radiation force (ARF) based elastography, including acoustic radiation force impulse (ARFI) imaging and harmonic motion imaging (HMI), have been developed to remotely assess the elastic properties of tissues. However, due to the lower operating frequencies of these approaches, their spatial resolutions are insufficient for revealing stiffness distribution on small scale applications, such as cancerous tumor margin detection, atherosclerotic plaque composition analysis and ophthalmologic tissue characterization. Though recently developed ARF-based optical coherence elastography (OCE) methods open a new window for the high resolution elastography, shallow imaging depths significantly limit their usefulness in clinics. Methods The aim of this study is to develop a high-resolution HMI method to assess the tissue biomechanical properties with acceptable field of view (FOV) using a 4 MHz ring transducer for efficient excitation and a 40 MHz needle transducer for accurate detection. Under precise alignment of two confocal transducers, the high-resolution HMI system has a lateral resolution of 314 µm and an axial resolution of 
147 µm with an effective FOV of 2 mm in depth. Results The performance of this high resolution imaging system was validated on the agar-based tissue mimicking phantoms with different stiffness distributions. These data demonstrated the imaging system’s improved resolution and sensitivity on differentiating materials with varying stiffness. In addition, ex vivo imaging of a human atherosclerosis coronary artery demonstrated the capability of high resolution HMI in identifying layer-specific structures and characterizing atherosclerotic plaques based on their stiffness differences. Conclusions All together high resolution HMI appears to be a promising ultrasound-only technology for characterizing tissue biomechanical properties at the microstructural level to improve the image-based diseases diagnosis in multiple clinical applications. PMID:25694960

Magnetic Analyzer Mavr for Study of Exotic Weakly Bound Nuclei

NASA Astrophysics Data System (ADS)

Maslov, V. A.; Kazacha, V. I.; Kolesov, I. V.; Lukyanov, S. M.; Melnikov, V. N.; Osipov, N. F.; Penionzhkevich, Yu. E.; Skobelev, N. K.; Sobolev, Yu. G.; Voskoboinik, E. I.

2015-06-01

A project of the high-resolution magnetic analyzer MAVR is proposed. The analyzer will comprise new magnetic optical and detecting systems for separation and identification of reaction products in a wide range of masses (5-150) and charges (1-60). The magnetic optical system consists of the MSP-144 magnet and a doublet of quadrupole lenses. This will allow the solid angle of the spectrometer to be increased by an order of magnitude up to 30 msr. The magnetic analyzer will have a high momentum resolution (10-4) and high focal-plane dispersion (1.9 m). It will allow products of nuclear reactions at energies up to 30 MeV/nucleon to be detected with the charge resolution ~1/60. Implementation of the project is divided into two stages: conversion of the magnetic analyzer proper and construction of the nuclear reaction products identification system. The MULTI detecting system is being developed for the MAVR magnetic analyzer to allow detection of nuclear reaction products and their identification by charge Q, atomic number Z, and mass A with a high absolute accuracy. The identification will be performed by measuring the energy loss (ΔE), time of flight (TOF), and total kinetic energy (TKE) of reaction products. The particle trajectories in the analyzer will also be determined using the drift chamber developed jointly with GANIL. The MAVR analyzer will operate in both primary beams of heavy ions and beams of radioactive nuclei produced by the U400 - U400M acceleration complex. It will also be used for measuring energy spectra of nuclear reaction products and as an energy monochromator.

Study of Exotic Weakly Bound Nuclei Using Magnetic Analyzer Mavr

NASA Astrophysics Data System (ADS)

Maslov, V. A.; Kazacha, V. I.; Kolesov, I. V.; Lukyanov, S. M.; Melnikov, V. N.; Osipov, N. F.; Penionzhkevich, Yu. E.; Skobelev, N. K.; Sobolev, Yu. G.; Voskoboinik, E. I.

2016-06-01

A project of the high-resolution magnetic analyzer MAVR is proposed. The analyzer will comprise new magnetic optical and detecting systems for separation and identification of reaction products in a wide range of masses (5-150) and charges (1-60). The magnetic optical system consists of the MSP-144 magnet and a doublet of quadrupole lenses. This will allow the solid angle of the spectrometer to be increased by an order of magnitude up to 30 msr. The magnetic analyzer will have a high momentum resolution (10-4) and high focal-plane dispersion (1.9 m). It will allow products of nuclear reactions at energies up to 30 MeV/nucleon to be detected with the charge resolution ∼1/60. Implementation of the project is divided into two stages: conversion of the magnetic analyzer proper and construction of the nuclear reaction products identification system. The MULTI detecting system is being developed for the MAVR magnetic analyzer to allow detection of nuclear reaction products and their identification by charge Q, atomic number Z, and mass A with a high absolute accuracy. The identification will be performed by measuring the energy loss (ΔE), time of flight (TOF), and total kinetic energy (TKE) of reaction products. The particle trajectories in the analyzer will also be determined using the drift chamber developed jointly with GANIL. The MAVR analyzer will operate in both primary beams of heavy ions and beams of radioactive nuclei produced by the U400 - U400M acceleration complex. It will also be used for measuring energy spectra of nuclear reaction products and as an energy monochromator.

The Assessment of Liver Reserve Function by Spectrophotometry based on Determination of Phenacetin and Paracetamol.

PubMed

Ren, Rui; Ma, Yongmei; Ma, Wanshan; Lu, Sumei

2015-01-01

To establish a technical system for assessing liver reserve function based on spectrophotometry by detection of phenacetin and paracetamol in blood samples. Taking detected contents of phenacetin and paracetamol by high performance liquid chromatography (HPLC) as standard, which was proved to be able to detect drug concentrations with high resolution and accuracy, we established a technical system based on the spectrophotometric technique to assay phenacetin and paracetamol, including the color system, the maximum absorption wavelength, the influence factors of color system, and the optimal conditions for hydrolysis. Then we verified our established system compared with that under HPLC by recovery test. This study established a technical system to detect phenacetin and paracetamol in blood samples using spectrophotometry. Mainly, 3 mol/L hydrochloric acid (HCl) was added to samples for hydrolysis for 30 minutes, then, adding 0.02% 1,2-naphthoquinone-4-sulfonate (NQS), 1% cetyltrimethyl ammonium bromide (CTA) and 2% sodium hydroxide (or 3% sodium carbonate) (ratio of 1:6:1:2 or 3), and the absorbance was measured at 500 nm and 570 nm to calculate their concentrations. Using an established spectrophotometric system to detect phenacetin and paracetamol in blood samples could assess liver reserve function, which was proved comparable with HPLC in resolution and repeatability.

LABORATORY EVALUATION OF A MICROFLUIDIC ELECTROCHEMICAL SENSOR FOR AEROSOL OXIDATIVE LOAD.

PubMed

Koehler, Kirsten; Shapiro, Jeffrey; Sameenoi, Yupaporn; Henry, Charles; Volckens, John

2014-05-01

Human exposure to particulate matter (PM) air pollution is associated with human morbidity and mortality. The mechanisms by which PM impacts human health are unresolved, but evidence suggests that PM intake leads to cellular oxidative stress through the generation of reactive oxygen species (ROS). Therefore, reliable tools are needed for estimating the oxidant generating capacity, or oxidative load, of PM at high temporal resolution (minutes to hours). One of the most widely reported methods for assessing PM oxidative load is the dithiothreitol (DTT) assay. The traditional DTT assay utilizes filter-based PM collection in conjunction with chemical analysis to determine the oxidation rate of reduced DTT in solution with PM. However, the traditional DTT assay suffers from poor time resolution, loss of reactive species during sampling, and high limit of detection. Recently, a new DTT assay was developed that couples a Particle-Into-Liquid-Sampler with microfluidic-electrochemical detection. This 'on-line' system allows high temporal resolution monitoring of PM reactivity with improved detection limits. This study reports on a laboratory comparison of the traditional and on-line DTT approaches. An urban dust sample was aerosolized in a laboratory test chamber at three atmospherically-relevant concentrations. The on-line system gave a stronger correlation between DTT consumption rate and PM mass (R 2 = 0.69) than the traditional method (R 2 = 0.40) and increased precision at high temporal resolution, compared to the traditional method.

Photonics-based real-time ultra-high-range-resolution radar with broadband signal generation and processing.

PubMed

Zhang, Fangzheng; Guo, Qingshui; Pan, Shilong

2017-10-23

Real-time and high-resolution target detection is highly desirable in modern radar applications. Electronic techniques have encountered grave difficulties in the development of such radars, which strictly rely on a large instantaneous bandwidth. In this article, a photonics-based real-time high-range-resolution radar is proposed with optical generation and processing of broadband linear frequency modulation (LFM) signals. A broadband LFM signal is generated in the transmitter by photonic frequency quadrupling, and the received echo is de-chirped to a low frequency signal by photonic frequency mixing. The system can operate at a high frequency and a large bandwidth while enabling real-time processing by low-speed analog-to-digital conversion and digital signal processing. A conceptual radar is established. Real-time processing of an 8-GHz LFM signal is achieved with a sampling rate of 500 MSa/s. Accurate distance measurement is implemented with a maximum error of 4 mm within a range of ~3.5 meters. Detection of two targets is demonstrated with a range-resolution as high as 1.875 cm. We believe the proposed radar architecture is a reliable solution to overcome the limitations of current radar on operation bandwidth and processing speed, and it is hopefully to be used in future radars for real-time and high-resolution target detection and imaging.

Use of an automatic resistivity system for detecting abandoned mine workings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peters, W.R.; Burdick, R.G.

1983-01-01

A high-resolution earth resistivity system has been designed and constructed for use as a means of detecting abandoned coal mine workings. The automatic pole-dipole earth resistivity technique has already been applied to the detection of subsurface voids for military applications. The hardware and software of the system are described, together with applications for surveying and mapping abandoned coal mine workings. Field tests are presented to illustrate the detection of both air-filled and water-filled mine workings.

Adaptive hyperspectral imager: design, modeling, and control

NASA Astrophysics Data System (ADS)

McGregor, Scot; Lacroix, Simon; Monmayrant, Antoine

2015-08-01

An adaptive, hyperspectral imager is presented. We propose a system with easily adaptable spectral resolution, adjustable acquisition time, and high spatial resolution which is independent of spectral resolution. The system yields the possibility to define a variety of acquisition schemes, and in particular near snapshot acquisitions that may be used to measure the spectral content of given or automatically detected regions of interest. The proposed system is modelled and simulated, and tests on a first prototype validate the approach to achieve near snapshot spectral acquisitions without resorting to any computationally heavy post-processing, nor cumbersome calibration

Proximal design for a multimodality endoscope with multiphoton microscopy, optical coherence microscopy and visual modalities

NASA Astrophysics Data System (ADS)

Kiekens, Kelli C.; Talarico, Olivia; Barton, Jennifer K.

2018-02-01

A multimodality endoscope system has been designed for early detection of ovarian cancer. Multiple illumination and detection systems must be integrated in a compact, stable, transportable configuration to meet the requirements of a clinical setting. The proximal configuration presented here supports visible light navigation with a large field of view and low resolution, high resolution multiphoton microscopy (MPM), and high resolution optical coherence microscopy (OCM). All modalities are integrated into a single optical system in the endoscope. The system requires two light sources: a green laser for visible light navigation and a compact fiber based femtosecond laser for MPM and OCM. Using an inline wavelength division multiplexer, the two sources are combined into a single mode fiber. To accomplish OCM, a fiber coupler is used to separate the femtosecond laser into a reference arm and signal arm. The reflected reference arm and the signal from the sample are interfered and wavelength separated by a reflection grating and detected using a linear array. The MPM signal is collimated and goes through a series of filters to separate the 2nd and 3rd harmonics as well as twophoton excitation florescence (2PEF) and 3PEF. Each signal is independently detected on a photo multiplier tube and amplified. The visible light is collected by multiple high numerical aperture fibers at the endoscope tip which are bundled into one SMA adapter at the proximal end and connected to a photodetector. This integrated system design is compact, efficient and meets both optical and mechanical requirements for clinical applications.

Detection of corn and weed species by the combination of spectral, shape and textural features

USDA-ARS?s Scientific Manuscript database

Accurate detection of weeds in farmland can help reduce pesticide use and protect the agricultural environment. To develop intelligent equipment for weed detection, this study used an imaging spectrometer system, which supports micro-scale plant feature analysis by acquiring high-resolution hyper sp...

Study and optimisation of SIMS performed with He+ and Ne+ bombardment

NASA Astrophysics Data System (ADS)

Pillatsch, L.; Vanhove, N.; Dowsett, D.; Sijbrandij, S.; Notte, J.; Wirtz, T.

2013-10-01

The combination of the high-brightness He+/Ne+ atomic level ion source with the detection capabilities of secondary ion mass spectrometry (SIMS) opens up the prospect of obtaining chemical information with high lateral resolution and high sensitivity on the Zeiss ORION helium ion microscope (HIM). A feasibility study with He+ and Ne+ ion bombardment is presented in order to determine the performance of SIMS analyses using the HIM. Therefore, the sputtering yields, useful yields and detection limits obtained for metallic (Al, Ni and W) as well as semiconductor samples (Si, Ge, GaAs and InP) were investigated. All the experiments were performed on a Cameca IMS4f SIMS instrument which was equipped with a caesium evaporator and oxygen flooding system. For most of the elements, useful yields in the range of 10-4 to 3 × 10-2 were measured with either O2 or Cs flooding. SIMS experiments performed directly on the ORION with a prototype secondary ion extraction and detection system lead to results that are consistent with those obtained on the IMS4f. Taking into account the obtained useful yields and the analytical conditions, such as the ion current and typical dwell time on the ORION HIM, detection limits in the at% range and better can be obtained during SIMS imaging at 10 nm lateral resolution with Ne+ bombardment and down to the ppm level when a lateral resolution of 100 nm is chosen. Performing SIMS on the HIM with a good detection limit while maintaining an excellent lateral resolution (<50 nm) is therefore very promising.

Redundancy management of multiple KT-70 inertial measurement units applicable to the space shuttle

NASA Technical Reports Server (NTRS)

Cook, L. J.

1975-01-01

Results of an investigation of velocity failure detection and isolation for 3 inertial measuring units (IMU) and 2 inertial measuring units (IMU) configurations are presented. The failure detection and isolation algorithm performance was highly successful and most types of velocity errors were detected and isolated. The failure detection and isolation algorithm also included attitude FDI but was not evaluated because of the lack of time and low resolution in the gimbal angle synchro outputs. The shuttle KT-70 IMUs will have dual-speed resolvers and high resolution gimbal angle readouts. It was demonstrated by these tests that a single computer utilizing a serial data bus can successfully control a redundant 3-IMU system and perform FDI.

Expanding the detection efficiency of silicon drift detectors

NASA Astrophysics Data System (ADS)

Schlosser, D. M.; Lechner, P.; Lutz, G.; Niculae, A.; Soltau, H.; Strüder, L.; Eckhardt, R.; Hermenau, K.; Schaller, G.; Schopper, F.; Jaritschin, O.; Liebel, A.; Simsek, A.; Fiorini, C.; Longoni, A.

2010-12-01

To expand the detection efficiency Silicon Drift Detectors (SDDs) with various customized radiation entrance windows, optimized detector areas and geometries have been developed. Optimum values for energy resolution, peak to background ratio (P/B) and high count rate capability support the development. Detailed results on sensors optimized for light element detection down to Boron or even lower will be reported. New developments for detecting medium and high X-ray energies by increasing the effective detector thickness will be presented. Gamma-ray detectors consisting of a SDD coupled to scintillators like CsI(Tl) and LaBr 3(Ce) have been examined. Results of the energy resolution for the 137Cs 662 keV line and the light yield (LY) of such detector systems will be reported.

High Frequency Electromagnetic Impedance Measurements for Characterization, Monitoring and Verification Efforts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Ki Ha; Becker, Alex; Framgos, William

1999-06-01

Non-invasive, high-resolution imaging of the shallow subsurface is needed for delineation of buried waste, detection of unexploded ordinance, verification and monitoring of containment structures, and other environmental applications. Electromagnetic measurements at frequencies between 1 and 100 MHz are important for such applications, because the induction number of many targets is small and the ability to determine the dielectric permittivity in addition to electrical conductivity of the subsurface is possible. Earlier workers were successful in developing systems for detecting anomalous areas, but no quantifiable information was accurately determined. For high-resolution imaging, accurate measurements are necessary so the field data can bemore » mapped into the space of the subsurface parameters. We are developing a non-invasive method for accurately imaging the electrical conductivity and dielectric permittivity of the shallow subsurface using the plane wave impedance approach. Electric and magnetic sensors are being tested in a known area against theoretical predictions, thereby insuring that the data collected with the high-frequency impedance (HFI) system will support high-resolution, multi-dimensional imaging techniques.« less

High-Frequency Electromagnetic Impedance Measurements for Characterization, Monitoring and Verification Efforts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Ki Ha; Becker, Alex; Tseng, Hung-Wen

2002-11-20

Non-invasive, high-resolution imaging of the shallow subsurface is needed for delineation of buried waste, detection of unexploded ordinance, verification and monitoring of containment structures, and other environmental applications. Electromagnetic (EM) measurements at frequencies between 1 and 100 MHz are important for such applications, because the induction number of many targets is small and the ability to determine the dielectric permittivity in addition to electrical conductivity of the subsurface is possible. Earlier workers were successful in developing systems for detecting anomalous areas, but no quantifiable information was accurately determined. For high-resolution imaging, accurate measurements are necessary so the field data canmore » be mapped into the space of the subsurface parameters. We are developing a non-invasive method for accurately mapping the electrical conductivity and dielectric permittivity of the shallow subsurface using the EM impedance approach (Frangos, 2001; Lee and Becker, 2001; Song et al., 2002). Electric and magnetic sensors are being tested in a known area against theoretical predictions, thereby insuring that the data collected with the high-frequency impedance (HFI) system will support high-resolution, multi-dimensional imaging techniques.« less

High-Frequency Electromagnetic Impedance Measurements for Characterization, Monitoring, and Verification Efforts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Ki Ha; Becker, Alex

2000-06-01

Non-invasive, high-resolution imaging of the shallow subsurface is needed for delineation of buried waste, detection of unexploded ordinance, verification and monitoring of containment structures, and other environmental applications. Electromagnetic measurements at frequencies between 1 and 100 MHz are important for such applications, because the induction number of many targets is small and the ability to determine the dielectric permittivity in addition to electrical conductivity of the subsurface is possible. Earlier workers were successful in developing systems for detecting anomalous areas, but no quantifiable information was accurately determined. For high-resolution imaging, accurate measurements are necessary so the field data can bemore » mapped into the space of the subsurface parameters. We are developing a non-invasive method for accurately imaging the electrical conductivity and dielectric permittivity of the shallow subsurface using the plane wave impedance approach (Song et al., 1997). Electric and magnetic sensors are being tested in a known area against theoretical predictions, thereby insuring that the data collected with the high-frequency impedance (HFI) system will support high-resolution, multi-dimensional imaging techniques.« less

High-Frequency Electromagnetic Impedance Measurements for Characterization, Monitoring and Verification Efforts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Ki Ha; Becker, Alex; Tseng, Hung-Wen

2001-06-10

Non-invasive, high-resolution imaging of the shallow subsurface is needed for delineation of buried waste, detection of unexploded ordinance, verification and monitoring of containment structures, and other environmental applications. Electromagnetic (EM) measurements at frequencies between 1 and 100 MHz are important for such applications, because the induction number of many targets is small and the ability to determine the dielectric permittivity in addition to electrical conductivity of the subsurface is possible. Earlier workers were successful in developing systems for detecting anomalous areas, but no quantifiable information was accurately determined. For high-resolution imaging, accurate measurements are necessary so the field data canmore » be mapped into the space of the subsurface parameters. We are developing a non-invasive method for accurately mapping the electrical conductivity and dielectric permittivity of the shallow subsurface using the EM impedance approach (Frangos, 2001; Lee and Becker, 2001). Electric and magnetic sensors are being tested in a known area against theoretical predictions, thereby insuring that the data collected with the high-frequency impedance (HFI) system will support high-resolution, multi-dimensional imaging techniques.« less

A High Resolution Scale-of-four

DOE R&D Accomplishments Database

Fitch, V.

1949-08-25

A high resolution scale-of-four has been developed to be used in conjunction with the nuclear particle detection devices in applications where the counting rate is unusually high. Specifically, it is intended to precede the commercially available medium resolution scaling circuits and so decrease the resolving time of the counting system. The circuit will function reliably on continuously recurring pulses separated by less than 0.1 microseconds. It will resolve two pulses (occurring at a moderate repetition rate) which are spaced at 0.04 microseconds. A five-volt input signal is sufficient to actuate the device.

Wide-bandwidth, wide-beamwidth, high-resolution, millimeter-wave imaging for concealed weapon detection

NASA Astrophysics Data System (ADS)

Sheen, David M.; Fernandes, Justin L.; Tedeschi, Jonathan R.; McMakin, Douglas L.; Jones, A. Mark; Lechelt, Wayne M.; Severtsen, Ronald H.

2013-05-01

Active millimeter-wave imaging is currently being used for personnel screening at airports and other high-security facilities. The cylindrical imaging techniques used in the deployed systems are based on licensed technology developed at the Pacific Northwest National Laboratory. The cylindrical and a related planar imaging technique form three-dimensional images by scanning a diverging beam swept frequency transceiver over a two-dimensional aperture and mathematically focusing or reconstructing the data into three-dimensional images of the person being screened. The resolution, clothing penetration, and image illumination quality obtained with these techniques can be significantly enhanced through the selection of the aperture size, antenna beamwidth, center frequency, and bandwidth. The lateral resolution can be improved by increasing the center frequency, or it can be increased with a larger antenna beamwidth. The wide beamwidth approach can significantly improve illumination quality relative to a higher frequency system. Additionally, a wide antenna beamwidth allows for operation at a lower center frequency resulting in less scattering and attenuation from the clothing. The depth resolution of the system can be improved by increasing the bandwidth. Utilization of extremely wide bandwidths of up to 30 GHz can result in depth resolution as fine as 5 mm. This wider bandwidth operation may allow for improved detection techniques based on high range resolution. In this paper, the results of an extensive imaging study that explored the advantages of using extremely wide beamwidth and bandwidth are presented, primarily for 10-40 GHz frequency band.

Shallow water imaging sonar system for environmental surveying. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-05-01

The scope of this research is to develop a shallow water sonar system designed to detect and map the location of objects such as hazardous wastes or discarded ordnance in coastal waters. The system will use high frequency wide-bandwidth imaging sonar, mounted on a moving platform towed behind a boat, to detect and identify objects on the sea bottom. Resolved images can be obtained even if the targets are buried in an overlayer of silt. The specific technical objective of this research was to develop and test a prototype system that is capable of (1) scan at high speeds (upmore » to 10m/s), even in shallow water (depth to ten meters), without motion blurring or loss of resolution; (2) produce images of the bottom structure that are detailed enough for unambiguous detection of objects as small as 15cm, even if they are buried up to 30cm deep in silt or sand. The critical technology involved uses an linear FM (LFM) or similar complex waveform, which has a high bandwidth for good range resolution, with a long pulse length for similar Dopper resolution. The lone duration signal deposits more energy on target than a narrower pulse, which increases the signal-to-noise ratio and signal-to-clutter ratio. This in turn allows the use of cheap, lightweight, low power, piezoelectric transducers at the 30--500 kHz range.« less

Chromatic Modulator for High Resolution CCD or APS Devices

NASA Technical Reports Server (NTRS)

Hartley, Frank T. (Inventor); Hull, Anthony B. (Inventor)

2003-01-01

A system for providing high-resolution color separation in electronic imaging. Comb drives controllably oscillate a red-green-blue (RGB) color strip filter system (or otherwise) over an electronic imaging system such as a charge-coupled device (CCD) or active pixel sensor (APS). The color filter is modulated over the imaging array at a rate three or more times the frame rate of the imaging array. In so doing, the underlying active imaging elements are then able to detect separate color-separated images, which are then combined to provide a color-accurate frame which is then recorded as the representation of the recorded image. High pixel resolution is maintained. Registration is obtained between the color strip filter and the underlying imaging array through the use of electrostatic comb drives in conjunction with a spring suspension system.

High-speed event detector for embedded nanopore bio-systems.

PubMed

Huang, Yiyun; Magierowski, Sebastian; Ghafar-Zadeh, Ebrahim; Wang, Chengjie

2015-08-01

Biological measurements of microscopic phenomena often deal with discrete-event signals. The ability to automatically carry out such measurements at high-speed in a miniature embedded system is desirable but compromised by high-frequency noise along with practical constraints on filter quality and sampler resolution. This paper presents a real-time event-detection method in the context of nanopore sensing that helps to mitigate these drawbacks and allows accurate signal processing in an embedded system. Simulations show at least a 10× improvement over existing on-line detection methods.

The development and test of multi-anode microchannel array detector systems. Part 2: Soft X-ray detectors

NASA Technical Reports Server (NTRS)

Timothy, J. G.

1986-01-01

Detector systems based on the high gain microchannel plate (MCP) electron multiplier were used extensively for imaging at soft X-ray wavelengths both on the ground and in space. The latest pulse counting electronic readout systems provide zero readout noise, spatial resolutions (FWHM) of 25 microns or better and can determine the arrival times of detected photons to an accuracy of the order of 100 ns. These systems can be developed to produce detectors with active areas of 100 nm in diameter or greater. The use of CsI photocathodes produces very high detective quantum efficiencies at wavelengths between about 100 and 1A (approximately 0.1 to 10 keV) with moderate energy resolution. The operating characteristics of the different types of soft X-ray MCP detector systems are described and the prospects for future developments are discussed.

Requirements on high resolution detectors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Koch, A.

For a number of microtomography applications X-ray detectors with a spatial resolution of 1 {mu}m are required. This high spatial resolution will influence and degrade other parameters of secondary importance like detective quantum efficiency (DQE), dynamic range, linearity and frame rate. This note summarizes the most important arguments, for and against those detector systems which could be considered. This article discusses the mutual dependencies between the various figures which characterize a detector, and tries to give some ideas on how to proceed in order to improve present technology.

Fast-time Simulation of an Automated Conflict Detection and Resolution Concept

NASA Technical Reports Server (NTRS)

Windhorst, Robert; Erzberger, Heinz

2006-01-01

This paper investigates the effect on the National Airspace System of reducing air traffc controller workload by automating conflict detection and resolution. The Airspace Concept Evaluation System is used to perform simulations of the Cleveland Center with conventional and with automated conflict detection and resolution concepts. Results show that the automated conflict detection and resolution concept significantly decreases growth of delay as traffic demand is increased in en-route airspace.

Photon theory hypothesis about photon tunneling microscope's subwavelength resolution

NASA Astrophysics Data System (ADS)

Zhu, Yanbin; Ma, Junfu

1995-09-01

The foundation for the invention of the photon scanning tunneling microscope (PSTM) are the near field scanning optical microscope, the optical fiber technique, the total internal reflection, high sensitive opto-electronic detecting technique and computer technique etc. Recent research results show the subwavelength resolution of 1 - 3 nm is obtained. How to explain the PSTM has got such high subwavelength resolution? What value is the PSTM's limiting of subwavelength resolution? For resolving these problems this paper presented a photon theory hypothesis about PSTM that is based on the following two basic laws: (1) Photon is not only a carrier bringing energy and optical information, but also is a particle occupied fixed space size. (2) When a photon happened reflection, refraction, scattering, etc., only changed its energy and optical information carried, its particle size doesn't change. g (DOT) pphoton equals constant. Using these two basic laws to PSTM, the `evanescent field' is practically a weak photon distribution field and the detecting fiber tip diameter is practically a `gate' which size controlled the photon numbers into fiber tip. Passing through some calculation and inference, the following three conclusions can be given: (1) Under the PSTM's detection system sensitivity is high enough, the diameter D of detecting fiber tip and the near field detecting distance Z are the two most important factors to decide the subwavelength resolution of PSTM. (2) The limiting of PSTM's resolution will be given upon the conditions of D equals pphoton and Z equals pphoton, where pphoton is one photon size. (2) The final resolution limit R of PSTM will be lim R equals pphoton, D yields pphoton, Z yields pphoton.

A front-end readout mixed chip for high-efficiency small animal PET imaging

NASA Astrophysics Data System (ADS)

Ollivier-Henry, N.; Berst, J. D.; Colledani, C.; Hu-Guo, Ch.; Mbow, N. A.; Staub, D.; Guyonnet, J. L.; Hu, Y.

2007-02-01

Today, the main challenge of Positron Emission Tomography (PET) systems dedicated to small animal imaging is to obtain high detection efficiency and a highly accurate localization of radioisotopes. If we focus only on the PET characteristics such as the spatial resolution, its accuracy depends on the design of detector and on the electronics readout system as well. In this paper, we present a new design of such readout system with full custom submicrometer CMOS implementation. The front end chip consists of two main blocks from which the energy information and the time stamp with subnanosecond resolution can be obtained. In our A Multi-Modality Imaging System for Small Animal (AMISSA) PET system design, a matrix of LYSO crystals has to be read at each end by a 64 channels multianode photomultiplier tube. A specific readout electronic has been developed at the Hubert Curien Multidisciplinary Institute (IPHC, France). The architecture of this readout for the energy information detection is composed of a low-noise preamplifier, a CR-RC shaper and an analogue memory. In order to obtain the required dynamic range from 15 to 650 photoelectrons with good linearity, a current mode approach has been chosen for the preamplifier. To detect the signal with a temporal resolution of 1 ns, a comparator with a very low threshold (˜0.3 photoelectron) has been implemented. It gives the time reference of arrival signal coming from the detector. In order to obtain the time coincidence with a temporal resolution of 1 ns, a Time-to-Digital Converter (TDC) based on a Delay-Locked-Loop (DLL) has been designed. The chip is fabricated with AMS 0.35 μm process. The ASIC architecture and some simulation results will be presented in the paper.

Resolution Enhanced Magnetic Sensing System for Wide Coverage Real Time UXO Detection

NASA Astrophysics Data System (ADS)

Zalevsky, Zeev; Bregman, Yuri; Salomonski, Nizan; Zafrir, Hovav

2012-09-01

In this paper we present a new high resolution automatic detection algorithm based upon a Wavelet transform and then validate it in marine related experiments. The proposed approach allows obtaining an automatic detection in a very low signal to noise ratios. The amount of calculations is reduced, the magnetic trend is depressed and the probability of detection/ false alarm rate can easily be controlled. Moreover, the algorithm enables to distinguish between close targets. In the algorithm we use the physical dependence of the magnetic field of a magnetic dipole in order to define a Wavelet mother function that later on can detect magnetic targets modeled as dipoles and embedded in noisy surrounding, at improved resolution. The proposed algorithm was realized on synthesized targets and then validated in field experiments involving a marine surface-floating system for wide coverage real time unexploded ordinance (UXO) detection and mapping. The detection probability achieved in the marine experiment was above 90%. The horizontal radial error of most of the detected targets was only 16 m and two baseline targets that were immersed about 20 m one to another could easily be distinguished.

Integrating Windblown Dust Forecasts with Public Safety and Health Systems

NASA Astrophysics Data System (ADS)

Sprigg, W. A.

2014-12-01

Experiments in real-time prediction of desert dust emissions and downstream plume concentrations (~ 3.5 km near-surface spatial resolution) succeed to the point of challenging public safety and public health services to beta test a dust storm warning and advisory system in lowering risks of highway and airline accidents and illnesses such as asthma and valley fever. Key beta test components are: high-resolution models of dust emission, entrainment and diffusion, integrated with synoptic weather observations and forecasts; satellite-based detection and monitoring of soil properties on the ground and elevated above; high space and time resolution for health surveillance and transportation advisories.

High mass resolution time of flight mass spectrometer for measuring products in heterogeneous catalysis in highly sensitive microreactors

NASA Astrophysics Data System (ADS)

Andersen, T.; Jensen, R.; Christensen, M. K.; Pedersen, T.; Hansen, O.; Chorkendorff, I.

2012-07-01

We demonstrate a combined microreactor and time of flight system for testing and characterization of heterogeneous catalysts with high resolution mass spectrometry and high sensitivity. Catalyst testing is performed in silicon-based microreactors which have high sensitivity and fast thermal response. Gas analysis is performed with a time of flight mass spectrometer with a modified nude Bayard-Alpert ionization gauge as gas ionization source. The mass resolution of the time of flight mass spectrometer using the ion gauge as ionization source is estimated to m/Δm > 2500. The system design is superior to conventional batch and flow reactors with accompanying product detection by quadrupole mass spectrometry or gas chromatography not only due to the high sensitivity, fast temperature response, high mass resolution, and fast acquisition time of mass spectra but it also allows wide mass range (0-5000 amu in the current configuration). As a demonstration of the system performance we present data from ammonia oxidation on a Pt thin film showing resolved spectra of OH and NH3.

High mass resolution time of flight mass spectrometer for measuring products in heterogeneous catalysis in highly sensitive microreactors.

PubMed

Andersen, T; Jensen, R; Christensen, M K; Pedersen, T; Hansen, O; Chorkendorff, I

2012-07-01

We demonstrate a combined microreactor and time of flight system for testing and characterization of heterogeneous catalysts with high resolution mass spectrometry and high sensitivity. Catalyst testing is performed in silicon-based microreactors which have high sensitivity and fast thermal response. Gas analysis is performed with a time of flight mass spectrometer with a modified nude Bayard-Alpert ionization gauge as gas ionization source. The mass resolution of the time of flight mass spectrometer using the ion gauge as ionization source is estimated to m/Δm > 2500. The system design is superior to conventional batch and flow reactors with accompanying product detection by quadrupole mass spectrometry or gas chromatography not only due to the high sensitivity, fast temperature response, high mass resolution, and fast acquisition time of mass spectra but it also allows wide mass range (0-5000 amu in the current configuration). As a demonstration of the system performance we present data from ammonia oxidation on a Pt thin film showing resolved spectra of OH and NH(3).

A graphical automated detection system to locate hardwood log surface defects using high-resolution three-dimensional laser scan data

Treesearch

Liya Thomas; R. Edward Thomas

2011-01-01

We have developed an automated defect detection system and a state-of-the-art Graphic User Interface (GUI) for hardwood logs. The algorithm identifies defects at least 0.5 inch high and at least 3 inches in diameter on barked hardwood log and stem surfaces. To summarize defect features and to build a knowledge base, hundreds of defects were measured, photographed, and...

Precision Targeting With a Tracking Adaptive Optics Scanning Laser Ophthalmoscope

DTIC Science & Technology

2006-01-01

automatic high- resolution mosaic generation, and automatic blink detection and tracking re-lock were also tested. The system has the potential to become an...structures can lead to earlier detection of retinal diseases such as age-related macular degeneration (AMD) and diabetic retinopathy (DR). Combined...optics systems sense perturbations in the detected wave-front and apply corrections to an optical element that flatten the wave-front and allow near

High-resolution surface plasmon resonance biosensing system for glucose concentration detecting

NASA Astrophysics Data System (ADS)

Huang, Xian; Li, Dachao; Yu, Haixia; Huang, Fuxiang; Hu, Xiaotang; Xu, Kexin

2007-02-01

Glucose is one of the most important substances widely contained in organism and food, thus people pay much attention in researching and improving the way for the detection of glucose. Traditional ways, although precise and reliable when in high concentration and large amount of sample, have unconvincing performance in detecting mixture and solution with low concentration and micro-volume. As far as the ideal way is concerned, it should not only specifically detect the glucose and exclude other components in solution, but also meet the need of micro-sample (approximately 5μL) and low concentration. We introduced D-galactose/D-glucose Binding Protein (GGBP) - a kind of protein which has the ability to absorb the glucose specifically, to construct a novel surface plasmon resonance measuring system. By immobilizing GGBP onto the surface of the SPR sensor, we develop a new detecting system for glucose testing in mixed solution. The experimental result indicates that compared with 0.1g/L before immobilization of GGBP, the detecting limit or the resolution of glucose testing rises to 1mg/L after the immobilization, the system succeeds in distinguishing glucose from other components in mixture, which reveals a bright future to apply SPR in the minimally invasive diabetes testing and food quality control.

SPED light sheet microscopy: fast mapping of biological system structure and function

PubMed Central

Tomer, Raju; Lovett-Barron, Matthew; Kauvar, Isaac; Andalman, Aaron; Burns, Vanessa M.; Sankaran, Sethuraman; Grosenick, Logan; Broxton, Michael; Yang, Samuel; Deisseroth, Karl

2016-01-01

The goal of understanding living nervous systems has driven interest in high-speed and large field-of-view volumetric imaging at cellular resolution. Light-sheet microscopy approaches have emerged for cellular-resolution functional brain imaging in small organisms such as larval zebrafish, but remain fundamentally limited in speed. Here we have developed SPED light sheet microscopy, which combines large volumetric field-of-view via an extended depth of field with the optical sectioning of light sheet microscopy, thereby eliminating the need to physically scan detection objectives for volumetric imaging. SPED enables scanning of thousands of volumes-per-second, limited only by camera acquisition rate, through the harnessing of optical mechanisms that normally result in unwanted spherical aberrations. We demonstrate capabilities of SPED microscopy by performing fast sub-cellular resolution imaging of CLARITY mouse brains and cellular-resolution volumetric Ca2+ imaging of entire zebrafish nervous systems. Together, SPED light sheet methods enable high-speed cellular-resolution volumetric mapping of biological system structure and function. PMID:26687363

In situ high temperature microwave microscope for nondestructive detection of surface and sub-surface defects.

PubMed

Wang, Peiyu; Li, Zhencheng; Pei, Yongmao

2018-04-16

An in situ high temperature microwave microscope was built for detecting surface and sub-subsurface structures and defects. This system was heated with a self-designed quartz lamp radiation module, which is capable of heating to 800°C. A line scanning of a metal grating showed a super resolution of 0.5 mm (λ/600) at 1 GHz. In situ scanning detections of surface hole defects on an aluminium plate and a glass fiber reinforced plastic (GFRP) plate were conducted at different high temperatures. A post processing algorithm was proposed to remove the background noises induced by high temperatures and the 3.0 mm-spaced hole defects were clearly resolved. Besides, hexagonal honeycomb lattices were in situ detected and clearly resolved under a 1.0 mm-thick face panel at 20°C and 50°C, respectively. The core wall positions and bonding width were accurately detected and evaluated. In summary, this in situ microwave microscope is feasible and effective in sub-surface detection and super resolution imaging at different high temperatures.

High-resolution spectral analysis of ammonia near 6.2 μm using a cw EC-QCL coupled with cavity ring-down spectroscopy.

PubMed

Maithani, Sanchi; Mandal, Santanu; Maity, Abhijit; Pal, Mithun; Pradhan, Manik

2018-04-30

We report on the development of a mid-infrared cavity ring-down spectrometer (CRDS) coupled with a continuous wave (cw) external cavity quantum cascade laser (EC-QCL), operating between 6.0 μm and 6.3 μm, for high-resolution spectroscopic studies of ammonia (NH3) which served as a bench-mark molecule in this spectral region. We characterized the EC-QCL based CRDS system in detail and achieved a noise-equivalent absorption (NEA) coefficient of 2.11 × 10-9 cm-1 Hz-1/2 for a 100 Hz data acquisition rate. We thereafter exploited the system for high-resolution spectroscopic analysis of interference-free 10 transition lines of the ν4 fundamental vibrational band of NH3 centred at ∼6.2 μm. We probed the strongest interference-free absorption line RQ(4,3) of ν4, centred at 1613.370 cm-1 for highly-sensitive trace detection of NH3 and subsequently achieved a minimum detection sensitivity (1σ) of 2.78 × 109 molecules per cm3 which translated into the detection limit of 740 parts-per-trillion by volume (pptv/10-12) at a pressure of 115 Torr for an integration time of ∼167 seconds. To demonstrate the efficacy of the present system in real-life applications, we finally measured the mixing ratios of NH3 present in ambient air and human exhaled breath with high sensitivity and molecular specificity.

Wide-field and high-resolution optical imaging for early detection of oral neoplasia

NASA Astrophysics Data System (ADS)

Pierce, Mark C.; Schwarz, Richard A.; Rosbach, Kelsey; Roblyer, Darren; Muldoon, Tim; Williams, Michelle D.; El-Naggar, Adel K.; Gillenwater, Ann M.; Richards-Kortum, Rebecca

2010-02-01

Current procedures for oral cancer screening typically involve visual inspection of the entire tissue surface at risk under white light illumination. However, pre-cancerous lesions can be difficult to distinguish from many benign conditions when viewed under these conditions. We have developed wide-field (macroscopic) imaging system which additionally images in cross-polarized white light, narrowband reflectance, and fluorescence imaging modes to reduce specular glare, enhance vascular contrast, and detect disease-related alterations in tissue autofluorescence. We have also developed a portable system to enable high-resolution (microscopic) evaluation of cellular features within the oral mucosa in situ. This system is a wide-field epi-fluorescence microscope coupled to a 1 mm diameter, flexible fiber-optic imaging bundle. Proflavine solution was used to specifically label cell nuclei, enabling the characteristic differences in N/C ratio and nuclear distribution between normal, dysplastic, and cancerous oral mucosa to be quantified. This paper discusses the technical design and performance characteristics of these complementary imaging systems. We will also present data from ongoing clinical studies aimed at evaluating diagnostic performance of these systems for detection of oral neoplasia.

Whole-animal imaging with high spatio-temporal resolution

NASA Astrophysics Data System (ADS)

Chhetri, Raghav; Amat, Fernando; Wan, Yinan; Höckendorf, Burkhard; Lemon, William C.; Keller, Philipp J.

2016-03-01

We developed isotropic multiview (IsoView) light-sheet microscopy in order to image fast cellular dynamics, such as cell movements in an entire developing embryo or neuronal activity throughput an entire brain or nervous system, with high resolution in all dimensions, high imaging speeds, good physical coverage and low photo-damage. To achieve high temporal resolution and high spatial resolution at the same time, IsoView microscopy rapidly images large specimens via simultaneous light-sheet illumination and fluorescence detection along four orthogonal directions. In a post-processing step, these four views are then combined by means of high-throughput multiview deconvolution to yield images with a system resolution of ≤ 450 nm in all three dimensions. Using IsoView microscopy, we performed whole-animal functional imaging of Drosophila embryos and larvae at a spatial resolution of 1.1-2.5 μm and at a temporal resolution of 2 Hz for up to 9 hours. We also performed whole-brain functional imaging in larval zebrafish and multicolor imaging of fast cellular dynamics across entire, gastrulating Drosophila embryos with isotropic, sub-cellular resolution. Compared with conventional (spatially anisotropic) light-sheet microscopy, IsoView microscopy improves spatial resolution at least sevenfold and decreases resolution anisotropy at least threefold. Compared with existing high-resolution light-sheet techniques, such as lattice lightsheet microscopy or diSPIM, IsoView microscopy effectively doubles the penetration depth and provides subsecond temporal resolution for specimens 400-fold larger than could previously be imaged.

Vegetation extraction from high-resolution satellite imagery using the Normalized Difference Vegetation Index (NDVI)

NASA Astrophysics Data System (ADS)

AlShamsi, Meera R.

2016-10-01

Over the past years, there has been various urban development all over the UAE. Dubai is one of the cities that experienced rapid growth in both development and population. That growth can have a negative effect on the surrounding environment. Hence, there has been a necessity to protect the environment from these fast pace changes. One of the major impacts this growth can have is on vegetation. As technology is evolving day by day, there is a possibility to monitor changes that are happening on different areas in the world using satellite imagery. The data from these imageries can be utilized to identify vegetation in different areas of an image through a process called vegetation detection. Being able to detect and monitor vegetation is very beneficial for municipal planning and management, and environment authorities. Through this, analysts can monitor vegetation growth in various areas and analyze these changes. By utilizing satellite imagery with the necessary data, different types of vegetation can be studied and analyzed, such as parks, farms, and artificial grass in sports fields. In this paper, vegetation features are detected and extracted through SAFIY system (i.e. the Smart Application for Feature extraction and 3D modeling using high resolution satellite ImagerY) by using high-resolution satellite imagery from DubaiSat-2 and DEIMOS-2 satellites, which provide panchromatic images of 1m resolution and spectral bands (red, green, blue and near infrared) of 4m resolution. SAFIY system is a joint collaboration between MBRSC and DEIMOS Space UK. It uses image-processing algorithms to extract different features (roads, water, vegetation, and buildings) to generate vector maps data. The process to extract green areas (vegetation) utilize spectral information (such as, the red and near infrared bands) from the satellite images. These detected vegetation features will be extracted as vector data in SAFIY system and can be updated and edited by end-users, such as governmental entities and municipalities.

Rapid calibrated high-resolution hyperspectral imaging using tunable laser source

NASA Astrophysics Data System (ADS)

Nguyen, Lam K.; Margalith, Eli

2009-05-01

We present a novel hyperspectral imaging technique based on tunable laser technology. By replacing the broadband source and tunable filters of a typical NIR imaging instrument, several advantages are realized, including: high spectral resolution, highly variable field-of-views, fast scan-rates, high signal-to-noise ratio, and the ability to use optical fiber for efficient and flexible sample illumination. With this technique, high-resolution, calibrated hyperspectral images over the NIR range can be acquired in seconds. The performance of system features will be demonstrated on two example applications: detecting melamine contamination in wheat gluten and separating bovine protein from wheat protein in cattle feed.

Star formation: Sibling rivalry begins at birth

NASA Astrophysics Data System (ADS)

Kratter, Kaitlin M.

2015-02-01

High-resolution astronomical observations of a nearby molecular gas cloud have revealed a quadruplet of stars in the act of formation. The system is arguably the youngest multiple star system detected so far. See Letter p.213

High contrast computed tomography with synchrotron radiation

NASA Astrophysics Data System (ADS)

Itai, Yuji; Takeda, Tohoru; Akatsuka, Takao; Maeda, Tomokazu; Hyodo, Kazuyuki; Uchida, Akira; Yuasa, Tetsuya; Kazama, Masahiro; Wu, Jin; Ando, Masami

1995-02-01

This article describes a new monochromatic x-ray CT system using synchrotron radiation with applications in biomedical diagnosis which is currently under development. The system is designed to provide clear images and to detect contrast materials at low concentration for the quantitative functional evaluation of organs in correspondence with their anatomical structures. In this system, with x-ray energy changing from 30 to 52 keV, images can be obtained to detect various contrast materials (iodine, barium, and gadolinium), and K-edge energy subtraction is applied. Herein, the features of the new system designed to enhance the advantages of SR are reported. With the introduction of a double-crystal monochromator, the high-order x-ray contamination is eliminated. The newly designed CCD detector with a wide dynamic range of 60 000:1 has a spatial resolution of 200 μm. The resulting image quality, which is expected to show improved contrast and spatial resolution, is currently under investigation.

Instrumentation of Molecular Imaging on Site-Specific Targeting Fluorescent Peptide for Early Detection of Breast Cancer

NASA Astrophysics Data System (ADS)

Yu, Ping; Ma, Lixin

2012-02-01

In this work we developed two biomedical imaging techniques for early detection of breast cancer. Both image modalities provide molecular imaging capability to probe site-specific targeting dyes. The first technique, heterodyne CCD fluorescence mediated tomography, is a non-invasive biomedical imaging that uses fluorescent photons from the targeted dye on the tumor cells inside human breast tissue. The technique detects a large volume of tissue (20 cm) with a moderate resolution (1 mm) and provides the high sensitivity. The second technique, dual-band spectral-domain optical coherence tomography, is a high-resolution tissue imaging modality. It uses a low coherence interferometer to detect coherent photons hidden in the incoherent background. Due to the coherence detection, a high resolution (20 microns) is possible. We have finished prototype imaging systems for the development of both image modalities and performed imaging experiments on tumor tissues. The spectroscopic/tomographic images show contrasts of dense tumor tissues and tumor necrotic regions. In order to correlate the findings from our results, a diffusion-weighted magnetic resonance imaging (MRI) of the tumors was performed using a small animal 7-Telsa MRI and demonstrated excellent agreement.

Un-collimated single-photon imaging system for high-sensitivity small animal and plant imaging.

PubMed

Walker, Katherine L; Judenhofer, Martin S; Cherry, Simon R; Mitchell, Gregory S

2015-01-07

In preclinical single-photon emission computed tomography (SPECT) system development the primary objective has been to improve spatial resolution by using novel parallel-hole or multi-pinhole collimator geometries. However, such high-resolution systems have relatively poor sensitivity (typically 0.01-0.1%). In contrast, a system that does not use collimators can achieve very high-sensitivity. Here we present a high-sensitivity un-collimated detector single-photon imaging (UCD-SPI) system for the imaging of both small animals and plants. This scanner consists of two thin, closely spaced, pixelated scintillator detectors that use NaI(Tl), CsI(Na), or BGO. The performance of the system has been characterized by measuring sensitivity, spatial resolution, linearity, detection limits, and uniformity. With (99m)Tc (140 keV) at the center of the field of view (20 mm scintillator separation), the sensitivity was measured to be 31.8% using the NaI(Tl) detectors and 40.2% with CsI(Na). The best spatial resolution (FWHM when the image formed as the geometric mean of the two detector heads, 20 mm scintillator separation) was 19.0 mm for NaI(Tl) and 11.9 mm for CsI(Na) at 140 keV, and 19.5 mm for BGO at 1116 keV, which is somewhat degraded compared to the cm-scale resolution obtained with only one detector head and a close source. The quantitative accuracy of the system's linearity is better than 2% with detection down to activity levels of 100 nCi. Two in vivo animal studies (a renal scan using (99m)Tc MAG-3 and a thyroid scan with (123)I) and one plant study (a (99m)TcO4(-) xylem transport study) highlight the unique capabilities of this UCD-SPI system. From the renal scan, we observe approximately a one thousand-fold increase in sensitivity compared to the Siemens Inveon SPECT/CT scanner. UCD-SPI is useful for many imaging tasks that do not require excellent spatial resolution, such as high-throughput screening applications, simple radiotracer uptake studies in tumor xenografts, dynamic studies where very good temporal resolution is critical, or in planta imaging of radioisotopes at low concentrations.

Rapid high-resolution spin- and angle-resolved photoemission spectroscopy with pulsed laser source and time-of-flight spectrometer

NASA Astrophysics Data System (ADS)

Gotlieb, K.; Hussain, Z.; Bostwick, A.; Lanzara, A.; Jozwiak, C.

2013-09-01

A high-efficiency spin- and angle-resolved photoemission spectroscopy (spin-ARPES) spectrometer is coupled with a laboratory-based laser for rapid high-resolution measurements. The spectrometer combines time-of-flight (TOF) energy measurements with low-energy exchange scattering spin polarimetry for high detection efficiencies. Samples are irradiated with fourth harmonic photons generated from a cavity-dumped Ti:sapphire laser that provides high photon flux in a narrow bandwidth, with a pulse timing structure ideally matched to the needs of the TOF spectrometer. The overall efficiency of the combined system results in near-EF spin-resolved ARPES measurements with an unprecedented combination of energy resolution and acquisition speed. This allows high-resolution spin measurements with a large number of data points spanning multiple dimensions of interest (energy, momentum, photon polarization, etc.) and thus enables experiments not otherwise possible. The system is demonstrated with spin-resolved energy and momentum mapping of the L-gap Au(111) surface states, a prototypical Rashba system. The successful integration of the spectrometer with the pulsed laser system demonstrates its potential for simultaneous spin- and time-resolved ARPES with pump-probe based measurements.

Development of High-Speed Fluorescent X-Ray Micro-Computed Tomography

NASA Astrophysics Data System (ADS)

Takeda, T.; Tsuchiya, Y.; Kuroe, T.; Zeniya, T.; Wu, J.; Lwin, Thet-Thet; Yashiro, T.; Yuasa, T.; Hyodo, K.; Matsumura, K.; Dilmanian, F. A.; Itai, Y.; Akatsuka, T.

2004-05-01

A high-speed fluorescent x-ray CT (FXCT) system using monochromatic synchrotron x rays was developed to detect very low concentration of medium-Z elements for biomedical use. The system is equipped two types of high purity germanium detectors, and fast electronics and software. Preliminary images of a 10mm diameter plastic phantom containing channels field with iodine solutions of different concentrations showed a minimum detection level of 0.002 mg I/ml at an in-plane spatial resolution of 100μm. Furthermore, the acquisition time was reduced about 1/2 comparing to previous system. The results indicate that FXCT is a highly sensitive imaging modality capable of detecting very low concentration of iodine, and that the method has potential in biomedical applications.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walker, Katherine L.; Judenhofer, Martin S.; Cherry, Simon R.

In preclinical single-photon emission computed tomography (SPECT) system development the primary objective has been to improve spatial resolution by using novel parallel-hole or multi-pinhole collimator geometries. Furthermore, such high-resolution systems have relatively poor sensitivity (typically 0.01% to 0.1%). In contrast, a system that does not use collimators can achieve very high-sensitivity. Here we present a high-sensitivity un-collimated detector single-photon imaging (UCD-SPI) system for the imaging of both small animals and plants. This scanner consists of two thin, closely spaced, pixelated scintillator detectors that use NaI(Tl), CsI(Na), or BGO. The performance of the system has been characterized by measuring sensitivity, spatialmore » resolution, linearity, detection limits, and uniformity. With 99mTc (140 keV) at the center of the field of view (20 mm scintillator separation), the sensitivity was measured to be 31.8% using the NaI(Tl) detectors and 40.2% with CsI(Na). The best spatial resolution (FWHM when the image formed as the geometric mean of the two detector heads, 20 mm scintillator separation) was 19.0 mm for NaI(Tl) and 11.9 mm for CsI(Na) at 140 keV, and 19.5 mm for BGO at 1116 keV, which is somewhat degraded compared to the cm-scale resolution obtained with only one detector head and a close source. The quantitative accuracy of the system’s linearity is better than 2% with detection down to activity levels of 100 nCi. Two in vivo animal studies (a renal scan using 99mTc MAG-3 and a thyroid scan with 123I) and one plant study (a 99mTcO 4- xylem transport study) highlight the unique capabilities of this UCD-SPI system. From the renal scan, we observe approximately a one thousand-fold increase in sensitivity compared to the Siemens Inveon SPECT/CT scanner. In conclusion, UCD-SPI is useful for many imaging tasks that do not require excellent spatial resolution, such as high-throughput screening applications, simple radiotracer uptake studies in tumor xenografts, dynamic studies where very good temporal resolution is critical, or in planta imaging of radioisotopes at low concentrations.« less

Performance evaluation of a high resolution dedicated breast PET scanner

DOE Office of Scientific and Technical Information (OSTI.GOV)

García Hernández, Trinitat, E-mail: mtrinitat@eresa.com; Vicedo González, Aurora; Brualla González, Luis

2016-05-15

Purpose: Early stage breast cancers may not be visible on a whole-body PET scan. To overcome whole-body PET limitations, several dedicated breast positron emission tomography (DbPET) systems have emerged nowadays aiming to improve spatial resolution. In this work the authors evaluate the performance of a high resolution dedicated breast PET scanner (Mammi-PET, Oncovision). Methods: Global status, uniformity, sensitivity, energy, and spatial resolution were measured. Spheres of different sizes (2.5, 4, 5, and 6 mm diameter) and various 18 fluorodeoxyglucose ({sup 18}F-FDG) activity concentrations were randomly inserted in a gelatine breast phantom developed at our institution. Several lesion-to-background ratios (LBR) weremore » simulated, 5:1, 10:1, 20:1, 30:1, and 50:1. Images were reconstructed using different voxel sizes. The ability of experienced reporters to detect spheres was tested as a function of acquisition time, LBR, sphere size, and matrix reconstruction voxel size. For comparison, phantoms were scanned in the DbPET camera and in a whole body PET (WB-PET). Two patients who just underwent WB-PET/CT exams were imaged with the DbPET system and the images were compared. Results: The measured absolute peak sensitivity was 2.0%. The energy resolution was 24.0% ± 1%. The integral and differential uniformity were 10% and 6% in the total field of view (FOV) and 9% and 5% in the central FOV, respectively. The measured spatial resolution was 2.0, 1.9, and 1.7 mm in the radial, tangential, and axial directions. The system exhibited very good detectability for spheres ≥4 mm and LBR ≥10 with a sphere detection of 100% when acquisition time was set >3 min/bed. For LBR = 5 and acquisition time of 7 min the detectability was 100% for spheres of 6 mm and 75% for spheres of 5, 4, and 2.5 mm. Lesion WB-PET detectability was only comparable to the DbPET camera for lesion sizes ≥5 mm when acquisition time was >3 min and LBR > 10. Conclusions: The DbPET has a good performance for its clinical use and shows an improved resolution and lesion detectability of small lesions compared to WB-PET.« less

Fast and high resolution thermal detector based on an aluminum nitride piezoelectric microelectromechanical resonator with an integrated suspended heat absorbing element

NASA Astrophysics Data System (ADS)

Hui, Yu; Rinaldi, Matteo

2013-03-01

This letter presents a miniaturized, fast, and high resolution thermal detector, in which a heat absorbing element and a temperature sensitive microelectromechanical system (MEMS) resonator are perfectly overlapped but separated by a microscale air gap. This unique design guarantees efficient and fast (˜10s μs) heat transfer from the absorbing element to the temperature sensitive device and enables high resolution thermal power detection (˜nW), thanks to the low noise performance of the high quality factor (Q = 2305) MEMS resonant thermal detector. A device prototype was fabricated, and its detection capabilities were experimentally characterized. A thermal power as low as 150 nW was experimentally measured, and a noise equivalent power of 6.5 nW/Hz1/2 was extracted. A device thermal time constant of only 350 μs was measured (smallest ever reported for MEMS resonant thermal detectors), indicating the great potential of the proposed technology for the implementation of ultra-fast and high resolution un-cooled resonant thermal detectors.

Note: Large active area solid state photon counter with 20 ps timing resolution and 60 fs detection delay stability

NASA Astrophysics Data System (ADS)

Prochazka, Ivan; Kodet, Jan; Eckl, Johann; Blazej, Josef

2017-10-01

We are reporting on the design, construction, and performance of a photon counting detector system, which is based on single photon avalanche diode detector technology. This photon counting device has been optimized for very high timing resolution and stability of its detection delay. The foreseen application of this detector is laser ranging of space objects, laser time transfer ground to space and fundamental metrology. The single photon avalanche diode structure, manufactured on silicon using K14 technology, is used as a sensor. The active area of the sensor is circular with 200 μm diameter. Its photon detection probability exceeds 40% in the wavelength range spanning from 500 to 800 nm. The sensor is operated in active quenching and gating mode. A new control circuit was optimized to maintain high timing resolution and detection delay stability. In connection to this circuit, timing resolution of the detector is reaching 20 ps FWHM. In addition, the temperature change of the detection delay is as low as 70 fs/K. As a result, the detection delay stability of the device is exceptional: expressed in the form of time deviation, detection delay stability of better than 60 fs has been achieved. Considering the large active area aperture of the detector, this is, to our knowledge, the best timing performance reported for a solid state photon counting detector so far.

Advances of a Brillouin Scattering Lidar System for the Detection of Temperature Profiles in the Ocean: Laboratory Measurements and Field Test

NASA Astrophysics Data System (ADS)

Walther, T.; Rupp, D.; Friman, S.; Trees, C.; Fournier, G.

2016-02-01

Recently we have demonstrated the feasibility of remotely measuring temperature profiles in water under a laboratory environment employing our real-time Brillouin Scattering LIDAR (BSL) system. The working principle is based on the frequency and time resolved detection of the backscattered spontaneous Brillouin signal of a short light pulse fired into the ocean. The light source consists of a frequency-doubled fiber-amplified External Cavity Diode Laser (ECDL) providing high-energy, Fourier transform-limited laser pulses in the green spectral range. The Brillouin shift is detected with high accuracy (low uncertainty) by employing an edge filter based on an Excited State Faraday Anomalous Dispersion Optical Filter (ESFADOF). Time-resolution allows for the depth resolution and the frequency resolved shift is proportional to the speed of sound. Thus, the temperature profile can be extracted from the measurements. In our laboratory setup we were able to resolve water temperatures with a mean accuracy of up to 0.07 oC and a spatial resolution of 1 m depending on the amount of averaging. In order to prepare the system for a first field test under realistic conditions on the coast of the Mediterranean at CMRE in La Spezia, almost all of the components have been upgraded. This first test is planned for November 2015. We will present the above mentioned measurements, details about the upgrades and report on our experiences during this maritime field test.Ultimately, the plan is to operate the system from a mobile platform, e.g., a helicopter or vessel, in order to precisely determine the temperature of the surface mixed layer of the ocean with high spatial resolution.

Objective tropical cyclone extratropical transition detection in high-resolution reanalysis and climate model data

DOE PAGES

Zarzycki, Colin M.; Thatcher, Diana R.; Jablonowski, Christiane

2017-01-22

This paper describes an objective technique for detecting the extratropical transition (ET) of tropical cyclones (TCs) in high-resolution gridded climate data. The algorithm is based on previous observational studies using phase spaces to define the symmetry and vertical thermal structure of cyclones. Storm tracking is automated, allowing for direct analysis of climate data. Tracker performance in the North Atlantic is assessed using 23 years of data from the variable-resolution Community Atmosphere Model (CAM) at two different resolutions (DX 55 km and 28 km), the Climate Forecast System Reanalysis (CFSR, DX 38 km), and the ERA-Interim Reanalysis (ERA-I, DX 80 km).more » The mean spatiotemporal climatologies and seasonal cycles of objectively detected ET in the observationally constrained CFSR and ERA-I are well matched to previous observational studies, demonstrating the capability of the scheme to adequately find events. High resolution CAM reproduces TC and ET statistics that are in general agreement with reanalyses. One notable model bias, however, is significantly longer time between ET onset and ET completion in CAM, particularly for TCs that lose symmetry prior to developing a cold-core structure and becoming extratropical cyclones, demonstrating the capability of this method to expose model biases in simulated cyclones beyond the tropical phase.« less

From SED HI concept to Pleiades FM detection unit measurements

NASA Astrophysics Data System (ADS)

Renard, Christophe; Dantes, Didier; Neveu, Claude; Lamard, Jean-Luc; Oudinot, Matthieu; Materne, Alex

2017-11-01

The first flight model PLEIADES high resolution instrument under Thales Alenia Space development, on behalf of CNES, is currently in integration and test phases. Based on the SED HI detection unit concept, PLEIADES detection unit has been fully qualified before the integration at telescope level. The main radiometric performances have been measured on engineering and first flight models. This paper presents the results of performances obtained on the both models. After a recall of the SED HI concept, the design and performances of the main elements (charge coupled detectors, focal plane and video processing unit), detection unit radiometric performances are presented and compared to the instrument specifications for the panchromatic and multispectral bands. The performances treated are the following: - video signal characteristics, - dark signal level and dark signal non uniformity, - photo-response non uniformity, - non linearity and differential non linearity, - temporal and spatial noises regarding system definitions PLEIADES detection unit allows tuning of different functions: reference and sampling time positioning, anti-blooming level, gain value, TDI line number. These parameters are presented with their associated criteria of optimisation to achieve system radiometric performances and their sensitivities on radiometric performances. All the results of the measurements performed by Thales Alenia Space on the PLEIADES detection units demonstrate the high potential of the SED HI concept for Earth high resolution observation system allowing optimised performances at instrument and satellite levels.

New photolysis system for NO2 measurements in the lower stratosphere

NASA Technical Reports Server (NTRS)

Gao, R. S.; Keim, E. R.; Woodbridge, E. L.; Ciciora, S. J.; Proffitt, M. H.; Thompson, T. L.; Mclaughlin, R. J.; Fahey, D. W.

1994-01-01

A new system for NO2 detection has been developed for use on the NASA ER-2 aircraft. The system converts NO2 to NO using UV photolysis with the NO product subsequently detected with an on-board chemiluminescence detector. The new system is compact, light weight, has high time resolution (approximately 1 s), and is significantly more efficient then some previous designs. Details of the system design and airborne performance are discussed.

A low noise photoelectric signal acquisition system applying in nuclear magnetic resonance gyroscope

NASA Astrophysics Data System (ADS)

Lu, Qilin; Zhang, Xian; Zhao, Xinghua; Yang, Dan; Zhou, Binquan; Hu, Zhaohui

2017-10-01

The nuclear magnetic resonance gyroscope serves as a new generation of strong support for the development of high-tech weapons, it solves the core problem that limits the development of the long-playing seamless navigation and positioning. In the NMR gyroscope, the output signal with atomic precession frequency is detected by the probe light, the final crucial photoelectric signal of the probe light directly decides the quality of the gyro signal. But the output signal has high sensitivity, resolution and measurement accuracy for the photoelectric detection system. In order to detect the measured signal better, this paper proposed a weak photoelectric signal rapid acquisition system, which has high SNR and the frequency of responded signal is up to 100 KHz to let the weak output signal with high frequency of the NMR gyroscope can be detected better.

Active Radiation Detectors for Use in Space Beyond Low Earth Orbit: Spatial and Energy Resolution Requirements and Methods for Heavy Ion Charge Classification

NASA Astrophysics Data System (ADS)

McBeth, Rafe A.

Space radiation exposure to astronauts will need to be carefully monitored on future missions beyond low earth orbit. NASA has proposed an updated radiation risk framework that takes into account a significant amount of radiobiological and heavy ion track structure information. These models require active radiation detection systems to measure the energy and ion charge Z. However, current radiation detection systems cannot meet these demands. The aim of this study was to investigate several topics that will help next generation detection systems meet the NASA objectives. Specifically, this work investigates the required spatial resolution to avoid coincident events in a detector, the effects of energy straggling and conversion of dose from silicon to water, and methods for ion identification (Z) using machine learning. The main results of this dissertation are as follows: 1. Spatial resolution on the order of 0.1 cm is required for active space radiation detectors to have high confidence in identifying individual particles, i.e., to eliminate coincident events. 2. Energy resolution of a detector system will be limited by energy straggling effects and the conversion of dose in silicon to dose in biological tissue (water). 3. Machine learning methods show strong promise for identification of ion charge (Z) with simple detector designs.

Un-collimated single-photon imaging system for high-sensitivity small animal and plant imaging

DOE PAGES

Walker, Katherine L.; Judenhofer, Martin S.; Cherry, Simon R.; ...

2014-12-12

In preclinical single-photon emission computed tomography (SPECT) system development the primary objective has been to improve spatial resolution by using novel parallel-hole or multi-pinhole collimator geometries. Furthermore, such high-resolution systems have relatively poor sensitivity (typically 0.01% to 0.1%). In contrast, a system that does not use collimators can achieve very high-sensitivity. Here we present a high-sensitivity un-collimated detector single-photon imaging (UCD-SPI) system for the imaging of both small animals and plants. This scanner consists of two thin, closely spaced, pixelated scintillator detectors that use NaI(Tl), CsI(Na), or BGO. The performance of the system has been characterized by measuring sensitivity, spatialmore » resolution, linearity, detection limits, and uniformity. With 99mTc (140 keV) at the center of the field of view (20 mm scintillator separation), the sensitivity was measured to be 31.8% using the NaI(Tl) detectors and 40.2% with CsI(Na). The best spatial resolution (FWHM when the image formed as the geometric mean of the two detector heads, 20 mm scintillator separation) was 19.0 mm for NaI(Tl) and 11.9 mm for CsI(Na) at 140 keV, and 19.5 mm for BGO at 1116 keV, which is somewhat degraded compared to the cm-scale resolution obtained with only one detector head and a close source. The quantitative accuracy of the system’s linearity is better than 2% with detection down to activity levels of 100 nCi. Two in vivo animal studies (a renal scan using 99mTc MAG-3 and a thyroid scan with 123I) and one plant study (a 99mTcO 4- xylem transport study) highlight the unique capabilities of this UCD-SPI system. From the renal scan, we observe approximately a one thousand-fold increase in sensitivity compared to the Siemens Inveon SPECT/CT scanner. In conclusion, UCD-SPI is useful for many imaging tasks that do not require excellent spatial resolution, such as high-throughput screening applications, simple radiotracer uptake studies in tumor xenografts, dynamic studies where very good temporal resolution is critical, or in planta imaging of radioisotopes at low concentrations.« less

Un-collimated single-photon imaging system for high-sensitivity small animal and plant imaging

NASA Astrophysics Data System (ADS)

Walker, Katherine L.; Judenhofer, Martin S.; Cherry, Simon R.; Mitchell, Gregory S.

2015-01-01

In preclinical single-photon emission computed tomography (SPECT) system development the primary objective has been to improve spatial resolution by using novel parallel-hole or multi-pinhole collimator geometries. However, such high-resolution systems have relatively poor sensitivity (typically 0.01-0.1%). In contrast, a system that does not use collimators can achieve very high-sensitivity. Here we present a high-sensitivity un-collimated detector single-photon imaging (UCD-SPI) system for the imaging of both small animals and plants. This scanner consists of two thin, closely spaced, pixelated scintillator detectors that use NaI(Tl), CsI(Na), or BGO. The performance of the system has been characterized by measuring sensitivity, spatial resolution, linearity, detection limits, and uniformity. With 99mTc (140 keV) at the center of the field of view (20 mm scintillator separation), the sensitivity was measured to be 31.8% using the NaI(Tl) detectors and 40.2% with CsI(Na). The best spatial resolution (FWHM when the image formed as the geometric mean of the two detector heads, 20 mm scintillator separation) was 19.0 mm for NaI(Tl) and 11.9 mm for CsI(Na) at 140 keV, and 19.5 mm for BGO at 1116 keV, which is somewhat degraded compared to the cm-scale resolution obtained with only one detector head and a close source. The quantitative accuracy of the system’s linearity is better than 2% with detection down to activity levels of 100 nCi. Two in vivo animal studies (a renal scan using 99mTc MAG-3 and a thyroid scan with 123I) and one plant study (a 99mTcO4- xylem transport study) highlight the unique capabilities of this UCD-SPI system. From the renal scan, we observe approximately a one thousand-fold increase in sensitivity compared to the Siemens Inveon SPECT/CT scanner. UCD-SPI is useful for many imaging tasks that do not require excellent spatial resolution, such as high-throughput screening applications, simple radiotracer uptake studies in tumor xenografts, dynamic studies where very good temporal resolution is critical, or in planta imaging of radioisotopes at low concentrations.

Magnetoacoustic microscopic imaging of conductive objects and nanoparticles distribution

NASA Astrophysics Data System (ADS)

Liu, Siyu; Zhang, Ruochong; Luo, Yunqi; Zheng, Yuanjin

2017-09-01

Magnetoacoustic tomography has been demonstrated as a powerful and low-cost multi-wave imaging modality. However, due to limited spatial resolution and detection efficiency of magnetoacoustic signal, full potential of the magnetoacoustic imaging remains to be tapped. Here we report a high-resolution magnetoacoustic microscopy method, where magnetic stimulation is provided by a compact solenoid resonance coil connected with a matching network, and acoustic reception is realized by using a high-frequency focused ultrasound transducer. Scanning the magnetoacoustic microscopy system perpendicularly to the acoustic axis of the focused transducer would generate a two-dimensional microscopic image with acoustically determined lateral resolution. It is analyzed theoretically and demonstrated experimentally that magnetoacoustic generation in this microscopic system depends on the conductivity profile of conductive objects and localized distribution of superparamagnetic iron magnetic nanoparticles, based on two different but related implementations. The lateral resolution is characterized. Directional nature of magnetoacoustic vibration and imaging sensitivity for mapping magnetic nanoparticles are also discussed. The proposed microscopy system offers a high-resolution method that could potentially map intrinsic conductivity distribution in biological tissue and extraneous magnetic nanoparticles.

Radar image processing of real aperture SLAR data for the detection and identification of iceberg and ship targets

NASA Technical Reports Server (NTRS)

Marthaler, J. G.; Heighway, J. E.

1979-01-01

An iceberg detection and identification system consisting of a moderate resolution Side Looking Airborne Radar (SLAR) interfaced with a Radar Image Processor (RIP) based on a ROLM 1664 computer with a 32K core memory updatable to 64K is described. The system can be operated in high- or low-resolution sampling modes. Specifically designed algorithms are applied to digitized signal returns to provide automatic target detection and location, geometrically correct video image display and data recording. The real aperture Motorola AN/APS-94D SLAR operates in the X-band and is tunable between 9.10 and 9.40 GHz; its output power is 45 kW peak with a pulse repetition rate of 750 pulses per hour. Schematic diagrams of the system are provided, together with preliminary test data.

Goaf water detection using the grounded electrical source airborne transient electromagnetic system

NASA Astrophysics Data System (ADS)

Li, D.; Ji, Y.; Guan, S.; Wu, Y.; Wang, A.

2017-12-01

To detect the geoelectric characteristic of goaf water, the grounded electrical source airborne transient electromagnetic (GREATEM) system (developed by Jilin University, China) is applied to the goaf water detection since its advantages of considerable prospecting depth, lateral resolution and detection efficiency. For the test of GREATEM system in goaf water detection, an experimental survey was conducted at Qinshui coal mine (Shanxi province, China). After data acquisition, noise reduction and inversion, the resistivity profiles of survey area is presented. The results highly agree the investigation information provided by Shanxi Coal Geology Geophysical Surveying Exploration Institute (China), conforming that the GREATEM system is an effective technique for resistivity detection of goaf water.

High-Frequency Electromagnetic Impedance Measurements for Characterization, Monitoring and Verification Efforts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Ki Ha; Becker, Alex; Tseng, Hung-Wen

2004-06-16

Non-invasive, high-resolution imaging of the shallow subsurface is needed for delineation of buried waste, detection of unexploded ordinance, verification and monitoring of containment structures, and other environmental applications. Electromagnetic (EM) measurements at frequencies between 0.1 and 100 MHz are important for such applications, because the induction number of many targets is small and the ability to determine the dielectric permittivity in addition to electrical conductivity of the subsurface is possible. Earlier workers were successful in developing systems for detecting anomalous areas, but no quantifiable information was accurately determined. For high-resolution imaging, accurate measurements are necessary so the field data canmore » be mapped into the space of the subsurface parameters. We are developing a non-invasive method for accurately mapping the electrical conductivity and dielectric permittivity of the shallow subsurface using the EM impedance approach (Frangos, 2001; Lee and Becker, 2001; Song et al., 2002, Tseng et al., 2003). Electric and magnetic sensors are being tested and calibrated on sea water and in a known area against theoretical predictions, thereby insuring that the data collected with the high-frequency impedance (HFI) system will support high-resolution, multi-dimensional imaging techniques.« less

Spotlight-Mode Synthetic Aperture Radar Processing for High-Resolution Lunar Mapping

NASA Technical Reports Server (NTRS)

Harcke, Leif; Weintraub, Lawrence; Yun, Sang-Ho; Dickinson, Richard; Gurrola, Eric; Hensley, Scott; Marechal, Nicholas

2010-01-01

During the 2008-2009 year, the Goldstone Solar System Radar was upgraded to support radar mapping of the lunar poles at 4 m resolution. The finer resolution of the new system and the accompanying migration through resolution cells called for spotlight, rather than delay-Doppler, imaging techniques. A new pre-processing system supports fast-time Doppler removal and motion compensation to a point. Two spotlight imaging techniques which compensate for phase errors due to i) out of focus-plane motion of the radar and ii) local topography, have been implemented and tested. One is based on the polar format algorithm followed by a unique autofocus technique, the other is a full bistatic time-domain backprojection technique. The processing system yields imagery of the specified resolution. Products enabled by this new system include topographic mapping through radar interferometry, and change detection techniques (amplitude and coherent change) for geolocation of the NASA LCROSS mission impact site.

Joint Sensing/Sampling Optimization for Surface Drifting Mine Detection with High-Resolution Drift Model

DTIC Science & Technology

2012-09-01

as potential tools for large area detection coverage while being moderately inexpensive (Wettergren, Performance of Search via Track - Before - Detect for...via Track - Before - Detect for Distribute 34 Sensor Networks, 2008). These statements highlight three specific needs to further sensor network research...Bay hydrography. Journal of Marine Systems, 12, 221–236. Wettergren, T. A. (2008). Performance of search via track - before - detect for distributed

Crop Phenology Detection Using High Spatio-Temporal Resolution Data Fused from SPOT5 and MODIS Products

PubMed Central

Zheng, Yang; Wu, Bingfang; Zhang, Miao; Zeng, Hongwei

2016-01-01

Timely and efficient monitoring of crop phenology at a high spatial resolution are crucial for the precise and effective management of agriculture. Recently, satellite-derived vegetation indices (VIs), such as the Normalized Difference Vegetation Index (NDVI), have been widely used for the phenology detection of terrestrial ecosystems. In this paper, a framework is proposed to detect crop phenology using high spatio-temporal resolution data fused from Systeme Probatoire d'Observation de la Tarre5 (SPOT5) and Moderate Resolution Imaging Spectroradiometer (MODIS) images. The framework consists of a data fusion method to produce a synthetic NDVI dataset at SPOT5’s spatial resolution and at MODIS’s temporal resolution and a phenology extraction algorithm based on NDVI time-series analysis. The feasibility of our phenology detection approach was evaluated at the county scale in Shandong Province, China. The results show that (1) the Spatial and Temporal Adaptive Reflectance Fusion Model (STARFM) algorithm can accurately blend SPOT5 and MODIS NDVI, with an R2 of greater than 0.69 and an root mean square error (RMSE) of less than 0.11 between the predicted and referenced data; and that (2) the estimated phenology parameters, such as the start and end of season (SOS and EOS), were closely correlated with the field-observed data with an R2 of the SOS ranging from 0.68 to 0.86 and with an R2 of the EOS ranging from 0.72 to 0.79. Our research provides a reliable approach for crop phenology mapping in areas with high fragmented farmland, which is meaningful for the implementation of precision agriculture. PMID:27973404

Crop Phenology Detection Using High Spatio-Temporal Resolution Data Fused from SPOT5 and MODIS Products.

PubMed

Zheng, Yang; Wu, Bingfang; Zhang, Miao; Zeng, Hongwei

2016-12-10

Timely and efficient monitoring of crop phenology at a high spatial resolution are crucial for the precise and effective management of agriculture. Recently, satellite-derived vegetation indices (VIs), such as the Normalized Difference Vegetation Index (NDVI), have been widely used for the phenology detection of terrestrial ecosystems. In this paper, a framework is proposed to detect crop phenology using high spatio-temporal resolution data fused from Systeme Probatoire d'Observation de la Tarre5 (SPOT5) and Moderate Resolution Imaging Spectroradiometer (MODIS) images. The framework consists of a data fusion method to produce a synthetic NDVI dataset at SPOT5's spatial resolution and at MODIS's temporal resolution and a phenology extraction algorithm based on NDVI time-series analysis. The feasibility of our phenology detection approach was evaluated at the county scale in Shandong Province, China. The results show that (1) the Spatial and Temporal Adaptive Reflectance Fusion Model (STARFM) algorithm can accurately blend SPOT5 and MODIS NDVI, with an R ² of greater than 0.69 and an root mean square error (RMSE) of less than 0.11 between the predicted and referenced data; and that (2) the estimated phenology parameters, such as the start and end of season (SOS and EOS), were closely correlated with the field-observed data with an R ² of the SOS ranging from 0.68 to 0.86 and with an R ² of the EOS ranging from 0.72 to 0.79. Our research provides a reliable approach for crop phenology mapping in areas with high fragmented farmland, which is meaningful for the implementation of precision agriculture.

Speed of sound and photoacoustic imaging with an optical camera based ultrasound detection system

NASA Astrophysics Data System (ADS)

Nuster, Robert; Paltauf, Guenther

2017-07-01

CCD camera based optical ultrasound detection is a promising alternative approach for high resolution 3D photoacoustic imaging (PAI). To fully exploit its potential and to achieve an image resolution <50 μm, it is necessary to incorporate variations of the speed of sound (SOS) in the image reconstruction algorithm. Hence, in the proposed work the idea and a first implementation are shown how speed of sound imaging can be added to a previously developed camera based PAI setup. The current setup provides SOS-maps with a spatial resolution of 2 mm and an accuracy of the obtained absolute SOS values of about 1%. The proposed dual-modality setup has the potential to provide highly resolved and perfectly co-registered 3D photoacoustic and SOS images.

Ultrahigh-Resolution Optical Coherence Tomography in Glaucoma

PubMed Central

Wollstein, Gadi; Paunescu, Leila A.; Ko, Tony H.; Fujimoto, James G.; Kowalevicz, Andrew; Hartl, Ingmar; Beaton, Siobahn; Ishikawa, Hiroshi; Mattox, Cynthia; Singh, Omah; Duker, Jay; Drexler, Wolfgang; Schuman, Joel S.

2007-01-01

Objective Optical coherence tomography (OCT) has been shown to be a valuable tool in glaucoma assessment. We investigated a new ultrahigh-resolution OCT (UHR-OCT) imaging system in glaucoma patients and compared the findings with those obtained by conventional-resolution OCT. Design Retrospective comparative case series. Participants A normal subject and 4 glaucoma patients representing various stages of glaucomatous damage. Testing All participants were scanned with StratusOCT (axial resolution of ~10 μm) and UHR-OCT (axial resolution of ~3 μm) at the same visit. Main Outcome Measure Comparison of OCT findings detected with StratusOCT and UHR-OCT. Results Ultrahigh-resolution OCT provides a detailed cross-sectional view of the scanned retinal area that allows differentiation between retinal layers. These UHR images were markedly better than those obtained by the conventional-resolution OCT. Conclusions Ultrahigh-resolution OCT provides high-resolution images of the ocular posterior segment, which improves the ability to detect retinal abnormalities due to glaucoma. PMID:15691556

New Non-Intrusive Inspection Technologies for Nuclear Security and Nonproliferation

NASA Astrophysics Data System (ADS)

Ledoux, Robert J.

2015-10-01

Comprehensive monitoring of the supply chain for nuclear materials has historically been hampered by non-intrusive inspection systems that have such large false alarm rates that they are impractical in the flow of commerce. Passport Systems, Inc. (Passport) has developed an active interrogation system which detects fissionable material, high Z material, and other contraband in land, sea and air cargo. Passport's design utilizes several detection modalities including high resolution imaging, passive radiation detection, effective-Z (EZ-3D™) anomaly detection, Prompt Neutrons from Photofission (PNPF), and Nuclear Resonance Fluorescence (NRF) isotopic identification. These technologies combine to: detect fissionable, high-Z, radioactive and contraband materials, differentiate fissionable materials from high-Z shielding materials, and isotopically identify actinides, Special Nuclear Materials (SNM), and other contraband (e.g. explosives, drugs, nerve agents). Passport's system generates a 3-D image of the scanned object which contains information such as effective-Z and density, as well as a 2-D image and isotopic and fissionable information for regions of interest.

A high-resolution, confocal laser-scanning microscope and flash photolysis system for physiological studies.

PubMed

Parker, I; Callamaras, N; Wier, W G

1997-06-01

We describe the construction of a high-resolution confocal laser-scanning microscope, and illustrate its use for studying elementary Ca2+ signalling events in cells. An avalanche photodiode module and simple optical path provide a high efficiency system for detection of fluorescence signals, allowing use of a small confocal aperture giving near diffraction-limited spatial resolution (< 300 nm lateral and < 400 nm axial). When operated in line-scan mode, the maximum temporal resolution is 1 ms, and the associated computer software allows complete flexibility to record line-scans continuously for long (minutes) periods or to obtain any desired pixel resolution in x-y scans. An independent UV irradiation system permits simultaneous photolysis of caged compounds over either a uniform, wide field (arc lamp source) or at a tightly focussed spot (frequency-tripled Nd:YAG laser). The microscope thus provides a versatile tool for optical studies of dynamic cellular processes, as well as excellent resolution for morphological studies. The confocal scanner can be added to virtually any inverted microscope for a component cost that is only a small fraction of that of comparable commercial instruments, yet offers better performance and greater versatility.

Light sheet theta microscopy for rapid high-resolution imaging of large biological samples.

PubMed

Migliori, Bianca; Datta, Malika S; Dupre, Christophe; Apak, Mehmet C; Asano, Shoh; Gao, Ruixuan; Boyden, Edward S; Hermanson, Ola; Yuste, Rafael; Tomer, Raju

2018-05-29

Advances in tissue clearing and molecular labeling methods are enabling unprecedented optical access to large intact biological systems. These developments fuel the need for high-speed microscopy approaches to image large samples quantitatively and at high resolution. While light sheet microscopy (LSM), with its high planar imaging speed and low photo-bleaching, can be effective, scaling up to larger imaging volumes has been hindered by the use of orthogonal light sheet illumination. To address this fundamental limitation, we have developed light sheet theta microscopy (LSTM), which uniformly illuminates samples from the same side as the detection objective, thereby eliminating limits on lateral dimensions without sacrificing the imaging resolution, depth, and speed. We present a detailed characterization of LSTM, and demonstrate its complementary advantages over LSM for rapid high-resolution quantitative imaging of large intact samples with high uniform quality. The reported LSTM approach is a significant step for the rapid high-resolution quantitative mapping of the structure and function of very large biological systems, such as a clarified thick coronal slab of human brain and uniformly expanded tissues, and also for rapid volumetric calcium imaging of highly motile animals, such as Hydra, undergoing non-isomorphic body shape changes.

Structural Information Detection Based Filter for GF-3 SAR Images

NASA Astrophysics Data System (ADS)

Sun, Z.; Song, Y.

2018-04-01

GF-3 satellite with high resolution, large swath, multi-imaging mode, long service life and other characteristics, can achieve allweather and all day monitoring for global land and ocean. It has become the highest resolution satellite system in the world with the C-band multi-polarized synthetic aperture radar (SAR) satellite. However, due to the coherent imaging system, speckle appears in GF-3 SAR images, and it hinders the understanding and interpretation of images seriously. Therefore, the processing of SAR images has big challenges owing to the appearance of speckle. The high-resolution SAR images produced by the GF-3 satellite are rich in information and have obvious feature structures such as points, edges, lines and so on. The traditional filters such as Lee filter and Gamma MAP filter are not appropriate for the GF-3 SAR images since they ignore the structural information of images. In this paper, the structural information detection based filter is constructed, successively including the point target detection in the smallest window, the adaptive windowing method based on regional characteristics, and the most homogeneous sub-window selection. The despeckling experiments on GF-3 SAR images demonstrate that compared with the traditional filters, the proposed structural information detection based filter can well preserve the points, edges and lines as well as smooth the speckle more sufficiently.

Room temperature X- and gamma-ray detectors using thallium bromide crystals

NASA Astrophysics Data System (ADS)

Hitomi, K.; Muroi, O.; Shoji, T.; Suehiro, T.; Hiratate, Y.

1999-10-01

Thallium bromide (TlBr) is a compound semiconductor with wide band gap (2.68eV) and high X- and γ-ray stopping power. The TlBr crystals were grown by the horizontal travelling molten zone (TMZ) method using purified material. Two types of room temperature X- and γ-ray detectors were fabricated from the TlBr crystals: TlBr detectors with high detection efficiency for positron annihilation γ-ray (511keV) detection and TlBr detectors with high-energy resolution for low-energy X-ray detection. The detector of the former type demonstrated energy resolution of 56keV FWHM (11%) for 511keV γ-rays. Energy resolution of 1.81keV FWHM for 5.9keV was obtained from the detector of the latter type. In order to analyze noise characteristics of the detector-preamplifier assembly, the equivalent noise charge (ENC) was measured as a function of the amplifier shaping time for the high-resolution detector. This analysis shows that parallel white noise and /1/f noise were dominant noise sources in the detector system. Current-voltage characteristics of the TlBr detector with a small Peltier cooler were also measured. Significant reduction of the detector leakage current was observed for the cooled detectors.

LETTER TO THE EDITOR: Combined optical and single photon emission imaging: preliminary results

NASA Astrophysics Data System (ADS)

Boschi, Federico; Spinelli, Antonello E.; D'Ambrosio, Daniela; Calderan, Laura; Marengo, Mario; Sbarbati, Andrea

2009-12-01

In vivo optical imaging instruments are generally devoted to the acquisition of light coming from fluorescence or bioluminescence processes. Recently, an instrument was conceived with radioisotopic detection capabilities (Kodak in Vivo Multispectral System F) based on the conversion of x-rays from the phosphorus screen. The goal of this work is to demonstrate that an optical imager (IVIS 200, Xenogen Corp., Alameda, USA), designed for in vivo acquisitions of small animals in bioluminescent and fluorescent modalities, can even be employed to detect signals due to radioactive tracers. Our system is based on scintillator crystals for the conversion of high-energy rays and a collimator. No hardware modifications are required. Crystals alone permit the acquisition of photons coming from an in vivo 20 g nude mouse injected with a solution of methyl diphosphonate technetium 99 metastable (Tc99m-MDP). With scintillator crystals and collimators, a set of measurements aimed to fully characterize the system resolution was carried out. More precisely, system point spread function and modulation transfer function were measured at different source depths. Results show that system resolution is always better than 1.3 mm when the source depth is less than 10 mm. The resolution of the images obtained with radioactive tracers is comparable with the resolution achievable with dedicated techniques. Moreover, it is possible to detect both optical and nuclear tracers or bi-modal tracers with only one instrument.

Integrated High Resolution Digital Color Light Sensor in 130 nm CMOS Technology.

PubMed

Strle, Drago; Nahtigal, Uroš; Batistell, Graciele; Zhang, Vincent Chi; Ofner, Erwin; Fant, Andrea; Sturm, Johannes

2015-07-22

This article presents a color light detection system integrated in 130 nm CMOS technology. The sensors and corresponding electronics detect light in a CIE XYZ color luminosity space using on-chip integrated sensors without any additional process steps, high-resolution analog-to-digital converter, and dedicated DSP algorithm. The sensor consists of a set of laterally arranged integrated photodiodes that are partly covered by metal, where color separation between the photodiodes is achieved by lateral carrier diffusion together with wavelength-dependent absorption. A high resolution, hybrid, ∑∆ ADC converts each photo diode's current into a 22-bit digital result, canceling the dark current of the photo diodes. The digital results are further processed by the DSP, which calculates normalized XYZ or RGB color and intensity parameters using linear transformations of the three photo diode responses by multiplication of the data with a transformation matrix, where the coefficients are extracted by training in combination with a pseudo-inverse operation and the least-mean square approximation. The sensor system detects the color light parameters with 22-bit accuracy, consumes less than 60 μA on average at 10 readings per second, and occupies approx. 0.8 mm(2) of silicon area (including three photodiodes and the analog part of the ADC). The DSP is currently implemented on FPGA.

Performance comparison of single and dual-excitation-wavelength resonance-Raman explosives detectors

NASA Astrophysics Data System (ADS)

Yellampalle, Balakishore; Martin, Robert; Witt, Kenneth; McCormick, William; Wu, Hai-Shan; Sluch, Mikhail; Ice, Robert; Lemoff, Brian

2017-05-01

Deep-ultraviolet Raman spectroscopy is a very useful approach for standoff detection of explosive traces. Using two simultaneous excitation wavelengths improves the specificity and sensitivity to standoff explosive detection. The High Technology Foundation developed a highly compact prototype of resonance Raman explosives detector. In this work, we discuss the relative performance of a dual-excitation sensor compared to a single-excitation sensor. We present trade space analysis comparing three representative Raman systems with similar size, weight, and power. The analysis takes into account, cost, spectral resolution, detection/identification time and the overall system benefit.

Detection of coal mine workings using high-resolution earth resistivity techniques. Final technical report, September 1979-September 1980

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peters, W.R.; Campbell, T.M.; Sturdivant, V.R.

1980-09-26

Shallow underground voids resulting from early coal mining and other resource recovery activities over the past several decades are now being recognized as a significant cause of ground subsidence problems in developing urban areas. Uncertain knowledge of abandoned coal mines also imposes potential hazards in coal excavation operations since water inundation or the release of methane gas is a principal hazard when mine excavation operations break into an abandoned mine. US Army requirements for an effective method for detecting and mapping subversive abandoned tunnels have resulted in a surface-operated automatic earth resistivity survey system with a digital computer data processingmore » system. Field tests aimed at demonstrating the system performance resulted in successful detection of tunnels having depth-to-diameter ratios up to 15 to 1. Under the sponsorship of the Bureau of Mines, a similar system was designed and constructed for use in the detection of coal mine workings. This report discusses the hardware and software aspects of the system and the application of the high-resolution earth resistivity method to the survey and mapping of abandoned coal mine workings. In the field tests reported, the targets of interest were both air- and water-filled workings.« less

JPL Fourier transform ultraviolet spectrometer

NASA Technical Reports Server (NTRS)

Cageao, R. P.; Friedl, R. R.; Sander, Stanley P.; Yung, Y. L.

1994-01-01

The Fourier Transform Ultraviolet Spectrometer (FTUVS) is a new high resolution interferometric spectrometer for multiple-species detection in the UV, visible and near-IR. As an OH sensor, measurements can be carried out by remote sensing (limb emission and column absorption), or in-situ sensing (long-path absorption or laser-induced fluorescence). As a high resolution detector in a high repetition rate (greater than 10 kHz) LIF system, OH fluorescence can be discriminated against non-resonant background emission and laser scatter, permitting (0, 0) excitation.

High-resolution broadband terahertz spectroscopy via electronic heterodyne detection of photonically generated terahertz frequency comb.

PubMed

Pavelyev, D G; Skryl, A S; Bakunov, M I

2014-10-01

We report an alternative approach to the terahertz frequency-comb spectroscopy (TFCS) based on nonlinear mixing of a photonically generated terahertz pulse train with a continuous wave signal from an electronic synthesizer. A superlattice is used as a nonlinear mixer. Unlike the standard TFCS technique, this approach does not require a complex double-laser system but retains the advantages of TFCS-high spectral resolution and wide bandwidth.

A thin wideband high-spatial-resolution focusing metasurface for near-field passive millimeter-wave imaging

NASA Astrophysics Data System (ADS)

Chu, Hongjun; Qi, Jiaran; Xiao, Shanshan; Qiu, Jinghui

2018-04-01

In this paper, we present a flat transmission-type focusing metasurface for the near-field passive millimeter-wave (PMMW) imaging systems. Considering the non-uniform wavefront of the actual feeding horn, the metasurface is configured by unit cells consisting of coaxial annular apertures and is optimized to achieve broadband, high spatial resolution, and polarization insensitive properties important for PMMW imaging applications in the frequency range from 33 GHz to 37 GHz, with the focal spot as small as 0.43λ0 (@35 GHz). A prototype of the proposed metasurface is fabricated, and the measurement results fairly agree with the simulation ones. Furthermore, an experimental single-sensor PMMW imaging system is constructed based on the metasurface and a Ka-band direct detection radiometer. The experimental results show that the azimuth resolution of the system can reach approximately 4 mm (≈0.47λ0). It is shown that the proposed metasurface can potentially replace the bulky dielectric-lens or reflector antenna to achieve possibly more compact PMMW imaging systems with high spatial resolution approaching the diffraction-limit.

Towards an integrated optofluidic system for highly sensitive detection of antibiotics in seawater incorporating bimodal waveguide photonic biosensors and complex, active microfluidics

NASA Astrophysics Data System (ADS)

Szydzik, C.; Gavela, A. F.; Roccisano, J.; Herranz de Andrés, S.; Mitchell, A.; Lechuga, L. M.

2016-12-01

We present recent results on the realisation and demonstration of an integrated optofluidic lab-on-a-chip measurement system. The system consists of an integrated on-chip automated microfluidic fluid handling subsystem, coupled with bimodal nano-interferometer waveguide technology, and is applied in the context of detection of antibiotics in seawater. The bimodal waveguide (BMWG) is a highly sensitive label-free biosensor. Integration of complex microfluidic systems with bimodal waveguide technology enables on-chip sample handling and fluid processing capabilities and allows for significant automation of experimental processes. The on-chip fluid-handling subsystem is realised through the integration of pneumatically actuated elastomer pumps and valves, enabling high temporal resolution sample and reagent delivery and facilitating multiplexed detection processes.

Photonic Generation and Detection of Arbitrary MMW Waveform for High-Resolution MMW Radar Imaging

DTIC Science & Technology

2014-12-06

20ft ~ 2cm Destribution A: Approved for public release. Distribution is unlimited. Fig. 1. The system setup for our MMW arbitrary waveform generation...IOA(AOARD) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) AOARD-134088 12. DISTRIBUTION/AVAILABILITY STATEMENT Destribution A: Approved for public...traveling carrier photodiode (NBUTC-PD), advanced optical pulse shaper system , and ultrafast TDS system to demonstrate the photonic generation and detection

Use of an automatic earth resistivity system for detection of abandoned mine workings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peters, W.R.; Burdick, R.

1982-04-01

Under the sponsorship of the US Bureau of Mines, a surface-operated automatic high resolution earth resistivity system and associated computer data processing techniques have been designed and constructed for use as a potential means of detecting abandoned coal mine workings. The hardware and software aspects of the new system are described together with applications of the method to the survey and mapping of abandoned mine workings.

Using natural archives to detect climate and environmental tipping points in the Earth System

NASA Astrophysics Data System (ADS)

Thomas, Zoë A.

2016-11-01

'Tipping points' in the Earth system are characterised by a nonlinear response to gradual forcing, and may have severe and wide-ranging impacts. Many abrupt events result from simple underlying system dynamics termed 'critical transitions' or 'bifurcations'. One of the best ways to identify and potentially predict threshold behaviour in the climate system is through analysis of natural ('palaeo') archives. Specifically, on the approach to a tipping point, early warning signals can be detected as characteristic fluctuations in a time series as a system loses stability. Testing whether these early warning signals can be detected in highly complex real systems is a key challenge, since much work is either theoretical or only tested with simple models. This is particularly problematic in palaeoclimate and palaeoenvironmental records with low resolution, non-equidistant data, which can limit accurate analysis. Here, a range of different datasets are examined to explore generic rules that can be used to detect such dramatic events. A number of key criteria are identified to be necessary for the reliable identification of early warning signals in natural archives, most crucially, the need for a low-noise record of sufficient data length, resolution and accuracy. A deeper understanding of the underlying system dynamics is required to inform the development of more robust system-specific indicators, or to indicate the temporal resolution required, given a known forcing. This review demonstrates that time series precursors from natural archives provide a powerful means of forewarning tipping points within the Earth System.

Quantum sensing with arbitrary frequency resolution

NASA Astrophysics Data System (ADS)

Boss, J. M.; Cujia, K. S.; Zopes, J.; Degen, C. L.

2017-05-01

Quantum sensing takes advantage of well-controlled quantum systems for performing measurements with high sensitivity and precision. We have implemented a concept for quantum sensing with arbitrary frequency resolution, independent of the qubit probe and limited only by the stability of an external synchronization clock. Our concept makes use of quantum lock-in detection to continuously probe a signal of interest. Using the electronic spin of a single nitrogen-vacancy center in diamond, we demonstrate detection of oscillating magnetic fields with a frequency resolution of 70 microhertz over a megahertz bandwidth. The continuous sampling further guarantees an enhanced sensitivity, reaching a signal-to-noise ratio in excess of 104 for a 170-nanotesla test signal measured during a 1-hour interval. Our technique has applications in magnetic resonance spectroscopy, quantum simulation, and sensitive signal detection.

Imaging the small animal cardiovascular system in real-time with multispectral optoacoustic tomography

NASA Astrophysics Data System (ADS)

Taruttis, Adrian; Herzog, Eva; Razansky, Daniel; Ntziachristos, Vasilis

2011-03-01

Multispectral Optoacoustic Tomography (MSOT) is an emerging technique for high resolution macroscopic imaging with optical and molecular contrast. We present cardiovascular imaging results from a multi-element real-time MSOT system recently developed for studies on small animals. Anatomical features relevant to cardiovascular disease, such as the carotid arteries, the aorta and the heart, are imaged in mice. The system's fast acquisition time, in tens of microseconds, allows images free of motion artifacts from heartbeat and respiration. Additionally, we present in-vivo detection of optical imaging agents, gold nanorods, at high spatial and temporal resolution, paving the way for molecular imaging applications.

Indoor imagery with a 3D through-wall synthetic aperture radar

NASA Astrophysics Data System (ADS)

Sévigny, Pascale; DiFilippo, David J.; Laneve, Tony; Fournier, Jonathan

2012-06-01

Through-wall radar imaging is an emerging technology with great interest to military and police forces operating in an urban environment. A through-wall imaging radar can potentially provide interior room layouts as well as detection and localization of targets of interest within a building. In this paper, we present our through-wall radar system mounted on the side of a vehicle and driven along a path in front of a building of interest. The vehicle is equipped with a LIDAR (Light Detection and Ranging) and motion sensors that provide auxiliary information. The radar uses an ultra wideband frequency-modulated continuous wave (FMCW) waveform to obtain high range resolution. Our system is composed of a vertical linear receive array to discriminate targets in elevation, and two transmit elements operated in a slow multiple-input multiple output (MIMO) configuration to increase the achievable elevation resolution. High resolution in the along-track direction is obtained through synthetic aperture radar (SAR) techniques. We present experimental results that demonstrate the 3-D capability of the radar. We further demonstrate target detection behind challenging walls, and imagery of internal wall features. Finally, we discuss future work.

Ultrahigh-resolution endoscopic optical coherence tomography

NASA Astrophysics Data System (ADS)

Chen, Yu; Herz, Paul R.; Hsiung, Pei-Lin; Aguirre, Aaron D.; Mashimo, Hiroshi; Desai, Saleem; Pedrosa, Macos; Koski, Amanda; Schmitt, Joseph M.; Fujimoto, James G.

2005-01-01

Early detection of gastrointestinal cancer is essential for the patient treatment and medical care. Endoscopically guided biopsy is currently the gold standard for the diagnosis of early esophageal cancer, but can suffer from high false negative rates due to sampling errors. Optical coherence tomography (OCT) is an emerging medical imaging technology which can generate high resolution, cross-sectional images of tissue in situ and in real time, without the removal of tissue specimen. Although endoscopic OCT has been used successfully to identify certain pathologies in the gastrointestinal tract, the resolution of current endoscopic OCT systems has been limited to 10 - 15 m for clinical procedures. In this study, in vivo imaging of the gastrointestinal tract is demonstrated at a three-fold higher resolution (< 5 m), using a portable, broadband, Cr4+:Forsterite laser as the optical light source. Images acquired from the esophagus, gastro-esophageal junction and colon on animal model display tissue microstructures and architectural details at high resolution, and the features observed in the OCT images are well-matched with histology. The clinical feasibility study is conducted through delivering OCT imaging catheter using standard endoscope. OCT images of normal esophagus, Barrett's esophagus, and esophageal cancers are demonstrated with distinct features. The ability of high resolution endoscopic OCT to image tissue morphology at an unprecedented resolution in vivo would facilitate the development of OCT as a potential imaging modality for early detection of neoplastic changes.

Music Identification System Using MPEG-7 Audio Signature Descriptors

PubMed Central

You, Shingchern D.; Chen, Wei-Hwa; Chen, Woei-Kae

2013-01-01

This paper describes a multiresolution system based on MPEG-7 audio signature descriptors for music identification. Such an identification system may be used to detect illegally copied music circulated over the Internet. In the proposed system, low-resolution descriptors are used to search likely candidates, and then full-resolution descriptors are used to identify the unknown (query) audio. With this arrangement, the proposed system achieves both high speed and high accuracy. To deal with the problem that a piece of query audio may not be inside the system's database, we suggest two different methods to find the decision threshold. Simulation results show that the proposed method II can achieve an accuracy of 99.4% for query inputs both inside and outside the database. Overall, it is highly possible to use the proposed system for copyright control. PMID:23533359

Immersive telepresence system using high-resolution omnidirectional movies and a locomotion interface

NASA Astrophysics Data System (ADS)

Ikeda, Sei; Sato, Tomokazu; Kanbara, Masayuki; Yokoya, Naokazu

2004-05-01

Technology that enables users to experience a remote site virtually is called telepresence. A telepresence system using real environment images is expected to be used in the field of entertainment, medicine, education and so on. This paper describes a novel telepresence system which enables users to walk through a photorealistic virtualized environment by actual walking. To realize such a system, a wide-angle high-resolution movie is projected on an immersive multi-screen display to present users the virtualized environments and a treadmill is controlled according to detected user's locomotion. In this study, we use an omnidirectional multi-camera system to acquire images real outdoor scene. The proposed system provides users with rich sense of walking in a remote site.

Performance of a Micro-Strip Gas Chamber for event wise, high rate thermal neutron detection with accurate 2D position determination

NASA Astrophysics Data System (ADS)

Mindur, B.; Alimov, S.; Fiutowski, T.; Schulz, C.; Wilpert, T.

2014-12-01

A two-dimensional (2D) position sensitive detector for neutron scattering applications based on low-pressure gas amplification and micro-strip technology was built and tested with an innovative readout electronics and data acquisition system. This detector contains a thin solid neutron converter and was developed for time- and thus wavelength-resolved neutron detection in single-event counting mode, which improves the image contrast in comparison with integrating detectors. The prototype detector of a Micro-Strip Gas Chamber (MSGC) was built with a solid natGd/CsI thermal neutron converter for spatial resolutions of about 100 μm and counting rates up to 107 neutrons/s. For attaining very high spatial resolutions and counting rates via micro-strip readout with centre-of-gravity evaluation of the signal amplitude distributions, a fast, channel-wise, self-triggering ASIC was developed. The front-end chips (MSGCROCs), which are very first signal processing components, are read out into powerful ADC-FPGA boards for on-line data processing and thereafter via Gigabit Ethernet link into the data receiving PC. The workstation PC is controlled by a modular, high performance dedicated software suite. Such a fast and accurate system is crucial for efficient radiography/tomography, diffraction or imaging applications based on high flux thermal neutron beam. In this paper a brief description of the detector concept with its operation principles, readout electronics requirements and design together with the signals processing stages performed in hardware and software are presented. In more detail the neutron test beam conditions and measurement results are reported. The focus of this paper is on the system integration, two dimensional spatial resolution, the time resolution of the readout system and the imaging capabilities of the overall setup. The detection efficiency of the detector prototype is estimated as well.

Detection and characterization of small hot fires: Comparing FireBird, BIRD, S-NPP VIIRS and MODIS capacities over gas flares

NASA Astrophysics Data System (ADS)

Ruecker, Gernot; Schroeder, Wilfrid; Lorenz, Eckehard; Kaiser, Johannes; Caseiro, Alexandre

2016-04-01

According to recent research, black carbon has the second strongest effect on the earth climate system after carbon dioxide. In high Northern latitudes, industrial gas flares are an important source of black carbon, especially in winter. This fact is particularly relevant for the relatively fast observed climate change in the Arctic since deposition of black carbon changes the albedo of snow and ice, thus leading to a positive feedback cycle. Here we explore gas flare detection and Fire Radiative Power (FRP) retrievals of the German FireBird TET-1 and BIRD Hotspot Recognition Systems (HSRS), the VIIRS sensor on board of the S-NPP satellite, and the MODIS sensor using temporally close to near coincident data acquisitions. Comparison is based on level 2 products developed for fire detection for the different sensors; in the case of S-NPP VIIRS we use two products: the new VIIRS 750m algorithm based on MODIS collection 6, and the 350 m algorithm based on the VIIRS mid-infrared I (Imaging) band, which offers high resolution, but no FRP retrievals. Results indicate that the highest resolution FireBird sensors offer the best detection capacities, though the level two product shows false alarms, followed by the VIIRS 350 m and 750 m algorithms. MODIS has the lowest detection rate. Preliminary results of FRP retrievals show that FireBird and VIIRS algorithms have a good agreement. Given the fact that most gas flaring is at the detection limit for medium to coarse resolution space borne sensors - and hence measurement errors may be high - our results indicates that a quantitative evaluation of gas flaring using these sensors is feasible. Results shall be used to develop a gas flare detection algorithm for Sentinel-3, and a similar methodology will be employed to validate the capacity of Sentinel 3 to detect and characterize small high temperature sources such as gas flares.

Oil defect detection of electrowetting display

NASA Astrophysics Data System (ADS)

Chiang, Hou-Chi; Tsai, Yu-Hsiang; Yan, Yung-Jhe; Huang, Ting-Wei; Mang, Ou-Yang

2015-08-01

In recent years, transparent display is an emerging topic in display technologies. Apply in many fields just like mobile device, shopping or advertising window, and etc. Electrowetting Display (EWD) is one kind of potential transparent display technology advantages of high transmittance, fast response time, high contrast and rich color with pigment based oil system. In mass production process of Electrowetting Display, oil defects should be found by Automated Optical Inspection (AOI) detection system. It is useful in determination of panel defects for quality control. According to the research of our group, we proposed a mechanism of AOI detection system detecting the different kinds of oil defects. This mechanism can detect different kinds of oil defect caused by oil overflow or material deteriorated after oil coating or driving. We had experiment our mechanism with a 6-inch Electrowetting Display panel from ITRI, using an Epson V750 scanner with 1200 dpi resolution. Two AOI algorithms were developed, which were high speed method and high precision method. In high precision method, oil jumping or non-recovered can be detected successfully. This mechanism of AOI detection system can be used to evaluate the oil uniformity in EWD panel process. In the future, our AOI detection system can be used in quality control of panel manufacturing for mass production.

A compact imaging spectroscopic system for biomolecular detections on plasmonic chips.

PubMed

Lo, Shu-Cheng; Lin, En-Hung; Wei, Pei-Kuen; Tsai, Wan-Shao

2016-10-17

In this study, we demonstrate a compact imaging spectroscopic system for high-throughput detection of biomolecular interactions on plasmonic chips, based on a curved grating as the key element of light diffraction and light focusing. Both the curved grating and the plasmonic chips are fabricated on flexible plastic substrates using a gas-assisted thermal-embossing method. A fiber-coupled broadband light source and a camera are included in the system. Spectral resolution within 1 nm is achieved in sensing environmental index solutions and protein bindings. The detected sensitivities of the plasmonic chip are comparable with a commercial spectrometer. An extra one-dimensional scanning stage enables high-throughput detection of protein binding on a designed plasmonic chip consisting of several nanoslit arrays with different periods. The detected resonance wavelengths match well with the grating equation under an air environment. Wavelength shifts between 1 and 9 nm are detected for antigens of various concentrations binding with antibodies. A simple, mass-productive and cost-effective method has been demonstrated on the imaging spectroscopic system for real-time, label-free, highly sensitive and high-throughput screening of biomolecular interactions.

Multi-resolution Gabor wavelet feature extraction for needle detection in 3D ultrasound

NASA Astrophysics Data System (ADS)

Pourtaherian, Arash; Zinger, Svitlana; Mihajlovic, Nenad; de With, Peter H. N.; Huang, Jinfeng; Ng, Gary C.; Korsten, Hendrikus H. M.

2015-12-01

Ultrasound imaging is employed for needle guidance in various minimally invasive procedures such as biopsy guidance, regional anesthesia and brachytherapy. Unfortunately, a needle guidance using 2D ultrasound is very challenging, due to a poor needle visibility and a limited field of view. Nowadays, 3D ultrasound systems are available and more widely used. Consequently, with an appropriate 3D image-based needle detection technique, needle guidance and interventions may significantly be improved and simplified. In this paper, we present a multi-resolution Gabor transformation for an automated and reliable extraction of the needle-like structures in a 3D ultrasound volume. We study and identify the best combination of the Gabor wavelet frequencies. High precision in detecting the needle voxels leads to a robust and accurate localization of the needle for the intervention support. Evaluation in several ex-vivo cases shows that the multi-resolution analysis significantly improves the precision of the needle voxel detection from 0.23 to 0.32 at a high recall rate of 0.75 (gain 40%), where a better robustness and confidence were confirmed in the practical experiments.

Detection and signal amplification in zebrafish RNA FISH.

PubMed

Hauptmann, Giselbert; Lauter, Gilbert; Söll, Iris

2016-04-01

In situ hybridization (ISH) has become an invaluable tool for the detection of RNA in cells, tissues and organisms. Due to improvements in target and signal amplification and in probe design remarkable progress has been made concerning sensitivity, specificity and resolution of chromogenic and fluorescent ISH (FISH). These advancements allow for exquisite cellular and sub-cellular resolution and for detecting multiple RNA species at a time by multiplexing. In zebrafish (F)ISH non-enzymatic and enzymatic amplification systems have been employed to obtain enhanced signal intensities and signal-to-noise ratios. These amplification strategies include branched DNA-based RNAscope and in situ hybridization chain reaction (HCR) techniques, as well as alkaline phosphatase (AP)- and horseradish peroxidase (PO)-based immunoassays. For practical application, we provide proven multiplex FISH protocols for AP- and PO-based visualization of mRNAs at high resolution. The protocols take advantage of optimized tyramide signal amplification (TSA) conditions of the PO assay and long-lasting high signal-to-noise ratio of the AP reaction, thereby enabling detection of less abundant transcripts. Copyright © 2016 Elsevier Inc. All rights reserved.

Radionuclide Methods and Instrumentation for Breast Cancer Detection and Diagnosis

PubMed Central

Surti, Suleman

2013-01-01

Breast cancer mammography is a well-acknowledged technique for patient screening due to its high sensitivity. However, in addition to its low specificity the sensitivity of mammography is limited when imaging patients with dense breasts. Radionuclide imaging techniques, such as coincidence photon-based positron emission tomography and single photon emission computed tomography or scintimammography, can play a role in assisting screening of such patients. Radionuclide techniques can also be useful in assessing treatment response of patients with breast cancer to therapy, and staging of patients to diagnose the disease extent. However, the performance of these imaging modalities is generally limited because of the poor spatial resolution and sensitivity of the commercially available multipurpose imaging systems. Here, we describe some of the dedicated imaging systems (positron emission mammography [PEM] and breast-specific gamma imaging [BSGI]) that have been developed both commercially and in research laboratories for radionuclide imaging of breast cancer. Clinical studies with dedicated PEM scanners show improved sensitivity to detecting cancer in patients when using PEM in conjunction with additional imaging modalities, such as magnetic resonance imaging or mammography or both, as well as improved disease staging that can have an effect on surgical planning. High-resolution BSGI systems are more widely available commercially and several clinical studies have shown very high sensitivity and specificity in detecting cancer in high-risk patients. Further development of dedicated PEM and BSGI systems is ongoing, promising further expansion of radionuclide imaging techniques in the realm of breast cancer detection and treatment. PMID:23725989

High Resolution PET Imaging Probe for the Detection, Molecular Characterization and Treatment Monitoring of Prostate Cancer

DTIC Science & Technology

2010-07-01

W81XWH-09-1-0420 TITLE: High Resolution PET Imaging Probe for the Detection, Molecular Characterization and Treatment Monitoring of Prostate Cancer...4. TITLE AND SUBTITLE High-Resolution PET Imaging Probe for the Detection, Molecular Characterization and Treatment of Prostate Cancer... molecular imaging for diagnosis as well as treatment planning and monitoring in prostate cancer. This investigation hypothesizes that a dedicated

Physical effects of mechanical design parameters on photon sensitivity and spatial resolution performance of a breast-dedicated PET system.

PubMed

Spanoudaki, V C; Lau, F W Y; Vandenbroucke, A; Levin, C S

2010-11-01

This study aims to address design considerations of a high resolution, high sensitivity positron emission tomography scanner dedicated to breast imaging. The methodology uses a detailed Monte Carlo model of the system structures to obtain a quantitative evaluation of several performance parameters. Special focus was given to the effect of dense mechanical structures designed to provide mechanical robustness and thermal regulation to the minuscule and temperature sensitive detectors. For the energies of interest around the photopeak (450-700 keV energy window), the simulation results predict a 6.5% reduction in the single photon detection efficiency and a 12.5% reduction in the coincidence photon detection efficiency in the case that the mechanical structures are interspersed between the detectors. However for lower energies, a substantial increase in the number of detected events (approximately 14% and 7% for singles at a 100-200 keV energy window and coincidences at a lower energy threshold of 100 keV, respectively) was observed with the presence of these structures due to backscatter. The number of photon events that involve multiple interactions in various crystal elements is also affected by the presence of the structures. For photon events involving multiple interactions among various crystal elements, the coincidence photon sensitivity is reduced by as much as 20% for a point source at the center of the field of view. There is no observable effect on the intrinsic and the reconstructed spatial resolution and spatial resolution uniformity. Mechanical structures can have a considerable effect on system sensitivity, especially for systems processing multi-interaction photon events. This effect, however, does not impact the spatial resolution. Various mechanical structure designs are currently under evaluation in order to achieve optimum trade-off between temperature stability, accurate detector positioning, and minimum influence on system performance.

Physical effects of mechanical design parameters on photon sensitivity and spatial resolution performance of a breast-dedicated PET system

PubMed Central

Spanoudaki, V. C.; Lau, F. W. Y.; Vandenbroucke, A.; Levin, C. S.

2010-01-01

Purpose: This study aims to address design considerations of a high resolution, high sensitivity positron emission tomography scanner dedicated to breast imaging. Methods: The methodology uses a detailed Monte Carlo model of the system structures to obtain a quantitative evaluation of several performance parameters. Special focus was given to the effect of dense mechanical structures designed to provide mechanical robustness and thermal regulation to the minuscule and temperature sensitive detectors. Results: For the energies of interest around the photopeak (450–700 keV energy window), the simulation results predict a 6.5% reduction in the single photon detection efficiency and a 12.5% reduction in the coincidence photon detection efficiency in the case that the mechanical structures are interspersed between the detectors. However for lower energies, a substantial increase in the number of detected events (approximately 14% and 7% for singles at a 100–200 keV energy window and coincidences at a lower energy threshold of 100 keV, respectively) was observed with the presence of these structures due to backscatter. The number of photon events that involve multiple interactions in various crystal elements is also affected by the presence of the structures. For photon events involving multiple interactions among various crystal elements, the coincidence photon sensitivity is reduced by as much as 20% for a point source at the center of the field of view. There is no observable effect on the intrinsic and the reconstructed spatial resolution and spatial resolution uniformity. Conclusions: Mechanical structures can have a considerable effect on system sensitivity, especially for systems processing multi-interaction photon events. This effect, however, does not impact the spatial resolution. Various mechanical structure designs are currently under evaluation in order to achieve optimum trade-off between temperature stability, accurate detector positioning, and minimum influence on system performance. PMID:21158296

Melon yield prediction using small unmanned aerial vehicles

NASA Astrophysics Data System (ADS)

Zhao, Tiebiao; Wang, Zhongdao; Yang, Qi; Chen, YangQuan

2017-05-01

Thanks to the development of camera technologies, small unmanned aerial systems (sUAS), it is possible to collect aerial images of field with more flexible visit, higher resolution and much lower cost. Furthermore, the performance of objection detection based on deeply trained convolutional neural networks (CNNs) has been improved significantly. In this study, we applied these technologies in the melon production, where high-resolution aerial images were used to count melons in the field and predict the yield. CNN-based object detection framework-Faster R-CNN is applied in the melon classification. Our results showed that sUAS plus CNNs were able to detect melons accurately in the late harvest season.

High-performance IR detector modules

NASA Astrophysics Data System (ADS)

Wendler, Joachim; Cabanski, Wolfgang; Rühlich, Ingo; Ziegler, Johann

2004-02-01

The 3rd generation of infrared (IR) detection modules is expected to provide higher video resolution, advanced functions like multi band or multi color capability, higher frame rates, and better thermal resolution. AIM has developed staring and linear high performance focal plane arrays (FPA) integrated into detector/dewar cooler assemblies (IDCA). Linear FPA"s support high resolution formats such as 1920 x 1152 (HDTV), 1280 x 960, or 1536 x 1152. Standard format for staring FPA"s is 640 x 512. In this configuration, QEIP devices sensitive in the 8 10 µm band as well as MCT devices sensitive in the 3.4 5.0 µm band are available. A 256 x 256 high speed detection module allows a full frame rate >800 Hz. Especially usability of long wavelength devices in high performance FLIR systems does not only depend on the classical electrooptical performance parameters such as NEDT, detectivity, and response homogeneity, but are mainly characterized by the stability of the correction coefficients used for image correction. The FPA"s are available in suited integrated detector/dewar cooler assemblies. The linear cooling engines are designed for maximum stability of the focal plane temperature, low operating temperatures down to 60K, high MTTF lifetimes of 6000h and above even under high ambient temperature conditions. The IDCA"s are equipped with AIM standard or custom specific command and control electronics (CCE) providing a well defined interface to the system electronics. Video output signals are provided as 14 bit digital data rates up to 80 MHz for the high speed devices.

Advances in algorithm fusion for automated sea mine detection and classification

NASA Astrophysics Data System (ADS)

Dobeck, Gerald J.; Cobb, J. Tory

2002-11-01

Along with other sensors, the Navy uses high-resolution sonar to detect and classify sea mines in mine-hunting operations. Scientists and engineers have devoted substantial effort to the development of automated detection and classification (D/C) algorithms for these high-resolution systems. Several factors spurred these efforts, including: (1) aids for operators to reduce work overload; (2) more optimal use of all available data; and (3) the introduction of unmanned minehunting systems. The environments where sea mines are typically laid (harbor areas, shipping lanes, and the littorals) give rise to many false alarms caused by natural, biologic, and manmade clutter. The objective of the automated D/C algorithms is to eliminate most of these false alarms while maintaining a very high probability of mine detection and classification (PdPc). In recent years, the benefits of fusing the outputs of multiple D/C algorithms (Algorithm Fusion) have been studied. To date, the results have been remarkable, including reliable robustness to new environments. In this paper a brief history of existing Algorithm Fusion technology and some techniques recently used to improve performance are presented. An exploration of new developments is presented in conclusion.

Disposable pen-shaped capillary gel electrophoresis cartridge for fluorescence detection of bio-molecules

NASA Astrophysics Data System (ADS)

Amirkhanian, Varoujan; Tsai, Shou-Kuan

2014-03-01

We introduce a novel and cost-effective capillary gel electrophoresis (CGE) system utilizing disposable pen-shaped gelcartridges for highly efficient, high speed, high throughput fluorescence detection of bio-molecules. The CGE system has been integrated with dual excitation and emission optical-fibers with micro-ball end design for fluorescence detection of bio-molecules separated and detected in a disposable pen-shaped capillary gel electrophoresis cartridge. The high-performance capillary gel electrophoresis (CGE) analyzer has been optimized for glycoprotein analysis type applications. Using commercially available labeling agent such as ANTS (8-aminonapthalene-1,3,6- trisulfonate) as an indicator, the capillary gel electrophoresis-based glycan analyzer provides high detection sensitivity and high resolving power in 2-5 minutes of separations. The system can hold total of 96 samples, which can be automatically analyzed within 4-5 hours. This affordable fiber optic based fluorescence detection system provides fast run times (4 minutes vs. 20 minutes with other CE systems), provides improved peak resolution, good linear dynamic range and reproducible migration times, that can be used in laboratories for high speed glycan (N-glycan) profiling applications. The CGE-based glycan analyzer will significantly increase the pace at which glycoprotein research is performed in the labs, saving hours of preparation time and assuring accurate, consistent and economical results.

Optical rotation based chirality detection of enantiomers via weak measurement in frequency domain

NASA Astrophysics Data System (ADS)

Li, Dongmei; Guan, Tian; Liu, Fang; Yang, Anping; He, Yonghong; He, Qinghua; Shen, Zhiyuan; Xin, Meiguo

2018-05-01

A transmission optical rotation detection scheme based on a weak measurement was proposed for the chirality detection of enantiomers. In this transmission weak measurement system in the frequency domain, the optical activity of the chiral liquid sample was estimated with the central wavelength shift, by modifying the preselected polarization state with the optical rotation (OR). The central wavelength shift of output spectra is sensitive to the OR angle but immune to the interference of the refractive index change caused by measuring circumstances. Two isomers of chiral amino acid acquired opposite responses with this system, and a resolution of 2.17 × 10-9 mol/ml for Proline detection could be obtained. Such a resolution is about 2 orders of magnitude higher than that of common methods, which shows a high sensitivity. This proposed weak measurement scenario suggested an approach to polarimetry and provided a way to accurately assess molecular chirality.

Simulated Performances of a Very High Energy Tomograph for Non-Destructive Characterization of large objects

NASA Astrophysics Data System (ADS)

Kistler, Marc; Estre, Nicolas; Merle, Elsa

2018-01-01

As part of its R&D activities on high-energy X-ray imaging for non-destructive characterization, the Nuclear Measurement Laboratory has started an upgrade of its imaging system currently implemented at the CEA-Cadarache center. The goals are to achieve a sub-millimeter spatial resolution and the ability to perform tomographies on very large objects (more than 100-cm standard concrete or 40-cm steel). This paper presentsresults on the detection part of the imaging system. The upgrade of the detection part needs a thorough study of the performance of two detectors: a series of CdTe semiconductor sensors and two arrays of segmented CdWO4 scintillators with different pixel sizes. This study consists in a Quantum Accounting Diagram (QAD) analysis coupled with Monte-Carlo simulations. The scintillator arrays are able to detect millimeter details through 140 cm of concrete, but are limited to 120 cm for smaller ones. CdTe sensors have lower but more stable performance, with a 0.5 mm resolution for 90 cm of concrete. The choice of the detector then depends on the preferred characteristic: the spatial resolution or the use on large volumes. The combination of the features of the source and the studies on the detectors gives the expected performance of the whole equipment, in terms of signal-over-noise ratio (SNR), spatial resolution and acquisition time.

High-frequency 3D echodentographic imaging modality for early assessment of periodontal diseases: in vitro study

NASA Astrophysics Data System (ADS)

Mahmoud, Ahmed M.; Ngan, Peter; Crout, Richard; Mukdadi, Osama M.

2009-02-01

The use of ultrasound in dentistry is still an open growing area of research. Currently, there is a lack of imaging modalities to accurately predict minute structures and defects in the jawbone. In particular, the inability of 2D radiographic images to detect bony periodontal defects resulted from infection of the periodontium. This study investigates the feasibility of high frequency ultrasound to reconstruct high resolution 3D surface images of human jawbone. Methods: A dentate and non-dentate mandibles were used in this study. The system employs high frequency single-element ultrasound focused transducers (15-30 MHz) for scanning. Continuous acquisition using a 1 GHz data acquisition card is synchronized with a high precision two-dimensional stage positioning system of +/-1 μm resolution for acquiring accurate and quantitative measurements of the mandible in vitro. Radio frequency (RF) signals are acquired laterally 44-45.5 μm apart for each frame. Different frames are reconstructed 500 μm apart for the 3D reconstruction. Signal processing algorithms are applied on the received ultrasound signals for filtering, focusing, and envelope detection before frame reconstruction. Furthermore, an edge detection technique is adopted to detect the bone surface in each frame. Finally, all edges are combined together in order to render a 3D surface image of the jawbone. Major anatomical landmarks on the resultant images were confirmed with the anatomical structures on the mandibles to show the efficacy of the system. Comparison were also made with conventional 2D radiographs to show the superiority of the ultrasound imaging system in diagnosing small defects in the lateral, axial and elevation planes of space. Results: The landmarks on all ultrasound images matched with those on the mandible, indicating the efficacy of the system in detecting small structures in human jaw bones. Comparison with conventional 2D radiographic images of the same mandible showed superiority of the 3D ultrasound images in detecting defects in the elevation plane of space. These results suggest that the high frequency ultrasound system shows great potential in providing a non-invasive method to characterize the jawbone and detect periodontal diseases at earlier stages.

Wide-Bandwidth, Wide-Beamwidth, High-Resolution, Millimeter-Wave Imaging for Concealed Weapon Detection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sheen, David M.; Fernandes, Justin L.; Tedeschi, Jonathan R.

2013-06-12

Active millimeter-wave imaging is currently being used for personnel screening at airports and other high-security facilities. The lateral resolution, depth resolution, clothing penetration, and image illumination quality obtained from next-generation systems can be significantly enhanced through the selection the aperture size, antenna beamwidth, center frequency, and bandwidth. In this paper, the results of an extensive imaging trade study are presented using both planar and cylindrical three-dimensional imaging techniques at frequency ranges of 10-20 GHz, 10 – 40 GHz, 40 – 60 GHz, and 75 – 105 GHz

A CMOS-based large-area high-resolution imaging system for high-energy x-ray applications

NASA Astrophysics Data System (ADS)

Rodricks, Brian; Fowler, Boyd; Liu, Chiao; Lowes, John; Haeffner, Dean; Lienert, Ulrich; Almer, John

2008-08-01

CCDs have been the primary sensor in imaging systems for x-ray diffraction and imaging applications in recent years. CCDs have met the fundamental requirements of low noise, high-sensitivity, high dynamic range and spatial resolution necessary for these scientific applications. State-of-the-art CMOS image sensor (CIS) technology has experienced dramatic improvements recently and their performance is rivaling or surpassing that of most CCDs. The advancement of CIS technology is at an ever-accelerating pace and is driven by the multi-billion dollar consumer market. There are several advantages of CIS over traditional CCDs and other solid-state imaging devices; they include low power, high-speed operation, system-on-chip integration and lower manufacturing costs. The combination of superior imaging performance and system advantages makes CIS a good candidate for high-sensitivity imaging system development. This paper will describe a 1344 x 1212 CIS imaging system with a 19.5μm pitch optimized for x-ray scattering studies at high-energies. Fundamental metrics of linearity, dynamic range, spatial resolution, conversion gain, sensitivity are estimated. The Detective Quantum Efficiency (DQE) is also estimated. Representative x-ray diffraction images are presented. Diffraction images are compared against a CCD-based imaging system.

Applying LED in full-field optical coherence tomography for gastrointestinal endoscopy

NASA Astrophysics Data System (ADS)

Yang, Bor-Wen; Wang, Yu-Yen; Juan, Yu-Shan; Hsu, Sheng-Jie

2015-08-01

Optical coherence tomography (OCT) has become an important medical imaging technology due to its non-invasiveness and high resolution. Full-field optical coherence tomography (FF-OCT) is a scanning scheme especially suitable for en face imaging as it employs a CMOS/CCD device for parallel pixels processing. FF-OCT can also be applied to high-speed endoscopic imaging. Applying cylindrical scanning and a right-angle prism, we successfully obtained a 360° tomography of the inner wall of an intestinal cavity through an FF-OCT system with an LED source. The 10-μm scale resolution enables the early detection of gastrointestinal lesions, which can increase detection rates for esophageal, stomach, or vaginal cancer. All devices used in this system can be integrated by MOEMS technology to contribute to the studies of gastrointestinal medicine and advanced endoscopy technology.

An improved RST approach for timely alert and Near Real Time monitoring of oil spill disasters by using AVHRR data

NASA Astrophysics Data System (ADS)

Grimaldi, C. S. L.; Casciello, D.; Coviello, I.; Lacava, T.; Pergola, N.; Tramutoli, V.

2011-05-01

Information acquired and provided in Near Real Time is fundamental in contributing to reduce the impact of different sea pollution sources on the maritime environment. Optical data acquired by sensors aboard meteorological satellites, thanks to their high temporal resolution as well as to their delivery policy, can be profitably used for a Near Real Time sea monitoring, provided that accurate and reliable methodologies for analysis and investigation are designed, implemented and fully assessed. In this paper, the results achieved by the application of an improved version of RST (Robust Satellite Technique) to oil spill detection and monitoring will be shown. In particular, thermal infrared data acquired by the NOAA-AVHRR (National Oceanic and Atmospheric Administration-Advanced Very High Resolution Radiometer) have been analyzed and a new RST-based change detection index applied to the case of the oil spills that occurred off the Kuwait and Saudi Arabian coasts in January 1991 and during the Lebanon War in July 2006. The results obtained, even in comparison with those achieved by other AVHRR-based techniques, confirm the unique performance of the proposed approach in automatically detecting the presence of oil spill with a high level of reliability and sensitivity. Moreover, the potential of the extension of the proposed technique to sensors onboard geostationary satellites will be discussed within the context of oil spill monitoring systems, integrating products generated by high temporal (optical) and high spatial (radar) resolution satellite systems.

Imaging and detection of early stage dental caries with an all-optical photoacoustic microscope

NASA Astrophysics Data System (ADS)

Hughes, D. A.; Sampathkumar, A.; Longbottom, C.; Kirk, K. J.

2015-01-01

Tooth decay, at its earliest stages, manifests itself as small, white, subsurface lesions in the enamel. Current methods for detection in the dental clinic are visual and tactile investigations, and bite-wing X-ray radiographs. These techniques suffer from poor sensitivity and specificity at the earliest (and reversible) stages of the disease due to the small size (<100μm) of the lesion. A fine-resolution (600 nm) ultra-broadband (200 MHz) all-optical photoacoustic microscopy system was is used to image the early signs of tooth decay. Ex-vivo tooth samples exhibiting white spot lesions were scanned and were found to generate a larger (one order of magnitude) photoacoustic (PA) signal in the lesion regions compared to healthy enamel. The high contrast in the PA images potentially allows lesions to be imaged and measured at a much earlier stage than current clinical techniques allow. PA images were cross referenced with histology photographs to validate our experimental results. Our PA system provides a noncontact method for early detection of white-spot lesions with a high detection bandwidth that offers advantages over previously demonstrated ultrasound methods. The technique provides the sensing depth of an ultrasound system, but with the spatial resolution of an optical system.

Companions in Color: High-Resolution Imaging of Kepler’s Sub-Neptune Host Stars

NASA Astrophysics Data System (ADS)

Ware, Austin; Wolfgang, Angie; Kannan, Deepti

2018-01-01

A current problem in astronomy is determining how sub-Neptune-sized exoplanets form in planetary systems. These kinds of planets, which fall between 1 and 4 times the size of Earth, were discovered in abundance by the Kepler Mission and were typically found with relatively short orbital periods. The combination of their size and orbital period make them unusual in relation to the Solar System, leading to the question of how these exoplanets form and evolve. One possibility is that they have been influenced by distant stellar companions. To help assess the influence of these objects on the present-day, observed properties of exoplanets, we conduct a NIR search for visual stellar companions to the stars around which the Kepler Mission discovered planets. We use high-resolution images obtained with the adaptive optics systems at the Lick Observatory Shane-3m telescope to find these companion stars. Importantly, we also determine the effective brightness and distance from the planet-hosting star at which it is possible to detect these companions. Out of the 200 KOIs in our sample, 42 KOIs (21%) have visual companions within 3”, and 90 (46%) have them within 6”. These findings are consistent with recent high-resolution imaging from Furlan et al. 2017 that found at least one visual companion within 4” for 31% of sampled KOIs (37% within 4" for our sample). Our results are also complementary to Furlan et al. 2017, with only 17 visual companions commonly detected in the same filter. As for detection limits, our preliminary results indicate that we can detect companion stars < 3-5 magnitudes fainter than the planet-hosting star at a separation of ~ 1”. These detection limits will enable us to determine the probability that possible companion stars could be hidden within the noise around the planet-hosting star, an important step in determining the frequency with which these short-period, sub-Neptune-sized planets occur within binary star systems.

Enhanced PET resolution by combining pinhole collimation and coincidence detection

NASA Astrophysics Data System (ADS)

DiFilippo, Frank P.

2015-10-01

Spatial resolution of clinical PET scanners is limited by detector design and photon non-colinearity. Although dedicated small animal PET scanners using specialized high-resolution detectors have been developed, enhancing the spatial resolution of clinical PET scanners is of interest as a more available alternative. Multi-pinhole 511 keV SPECT is capable of high spatial resolution but requires heavily shielded collimators to avoid significant background counts. A practical approach with clinical PET detectors is to combine multi-pinhole collimation with coincidence detection. In this new hybrid modality, there are three locations associated with each event, namely those of the two detected photons and the pinhole aperture. These three locations over-determine the line of response and provide redundant information that is superior to coincidence detection or pinhole collimation alone. Multi-pinhole collimation provides high resolution and avoids non-colinearity error but is subject to collimator penetration and artifacts from overlapping projections. However the coincidence information, though at lower resolution, is valuable for determining whether the photon passed near a pinhole within the cone acceptance angle and for identifying through which pinhole the photon passed. This information allows most photons penetrating through the collimator to be rejected and avoids overlapping projections. With much improved event rejection, a collimator with minimal shielding may be used, and a lightweight add-on collimator for high resolution imaging is feasible for use with a clinical PET scanner. Monte Carlo simulations were performed of a 18F hot rods phantom and a 54-pinhole unfocused whole-body mouse collimator with a clinical PET scanner. Based on coincidence information and pinhole geometry, events were accepted or rejected, and pinhole-specific crystal-map projections were generated. Tomographic images then were reconstructed using a conventional pinhole SPECT algorithm. Hot rods of 1.4 mm diameter were resolved easily in a simulated phantom. System sensitivity was 0.09% for a simulated 70-mm line source corresponding to the NEMA NU-4 mouse phantom. Higher resolution is expected with further optimization of pinhole design, and higher sensitivity is expected with a focused and denser pinhole configuration. The simulations demonstrate high spatial resolution and feasibility of small animal imaging with an add-on multi-pinhole collimator for a clinical PET scanner. Further work is needed to develop geometric calibration and quantitative data corrections and, eventually, to construct a prototype device and produce images with physical phantoms.

Fast tomosynthesis for lung cancer detection using the SBDX geometry

NASA Astrophysics Data System (ADS)

Fahrig, Rebecca; Pineda, Angel R.; Solomon, Edward G.; Leung, Ann N.; Pelc, Norbert J.

2003-06-01

Radiology-based lung-cancer detection is a high-contrast imaging task, consisting of the detection of a small mass of tissue within much lower density lung parenchyma. This imaging task requires removal of confounding image details, fast image acquisition (< 0.1 s for pericardial region), low dose (comparable to a chest x-ray), high resolution (< 0.25 mm in-plane) and patient positioning flexibility. We present an investigation of tomosynthesis, implemented using the Scanning-Beam Digital X-ray System (SBDX), to achieve these goals. We designed an image-based computer model of tomosynthesis using a high-resolution (0.15-mm isotropic voxels), low-noise CT volume image of a lung phantom, numerically added spherical lesions and convolution-based tomographic blurring. Lesion visibility was examined as a function of half-tomographic angle for 2.5 and 4.0 mm diameter lesions. Gaussian distributed noise was added to the projected images. For lesions 2.5 mm and 4.0 mm in diameter, half-tomographic angles of at least 6° and 9° respectively were necessary before visualization of the lesions improved. The addition of noise for a dose equivalent to 1/10 that used for a standard chest radiograph did not significantly impair lesion detection. The results are promising, indicating that lung-cancer detection using a modified SBDX system is possible.

Comparison of four machine learning methods for object-oriented change detection in high-resolution satellite imagery

NASA Astrophysics Data System (ADS)

Bai, Ting; Sun, Kaimin; Deng, Shiquan; Chen, Yan

2018-03-01

High resolution image change detection is one of the key technologies of remote sensing application, which is of great significance for resource survey, environmental monitoring, fine agriculture, military mapping and battlefield environment detection. In this paper, for high-resolution satellite imagery, Random Forest (RF), Support Vector Machine (SVM), Deep belief network (DBN), and Adaboost models were established to verify the possibility of different machine learning applications in change detection. In order to compare detection accuracy of four machine learning Method, we applied these four machine learning methods for two high-resolution images. The results shows that SVM has higher overall accuracy at small samples compared to RF, Adaboost, and DBN for binary and from-to change detection. With the increase in the number of samples, RF has higher overall accuracy compared to Adaboost, SVM and DBN.

Resolution enhancement of pump-probe microscope with an inverse-annular filter

NASA Astrophysics Data System (ADS)

Kobayashi, Takayoshi; Kawasumi, Koshi; Miyazaki, Jun; Nakata, Kazuaki

2018-04-01

Optical pump-probe microscopy can provide images by detecting changes in probe light intensity induced by stimulated emission, photoinduced absorbance change, or photothermal-induced refractive index change in either transmission or reflection mode. Photothermal microscopy, which is one type of optical pump-probe microscopy, has intrinsically super resolution capability due to the bilinear dependence of signal intensity of pump and probe. We introduce new techniques for further resolution enhancement and fast imaging in photothermal microscope. First, we introduce a new pupil filter, an inverse-annular pupil filter in a pump-probe photothermal microscope, which provides resolution enhancement in three dimensions. The resolutions are proved to be improved in lateral and axial directions by imaging experiment using 20-nm gold nanoparticles. The improvement in X (perpendicular to the common pump and probe polarization direction), Y (parallel to the polarization direction), and Z (axial direction) are by 15 ± 6, 8 ± 8, and 21 ± 2% from the resolution without a pupil filter. The resolution enhancement is even better than the calculation using vector field, which predicts the corresponding enhancement of 11, 8, and 6%. The discussion is made to explain the unexpected results. We also demonstrate the photothermal imaging of thick biological samples (cells from rabbit intestine and kidney) stained with hematoxylin and eosin dye with the inverse-annular filter. Second, a fast, high-sensitivity photothermal microscope is developed by implementing a spatially segmented balanced detection scheme into a laser scanning microscope using a Galvano mirror. We confirm a 4.9 times improvement in signal-to-noise ratio in the spatially segmented balanced detection compared with that of conventional detection. The system demonstrates simultaneous bi-modal photothermal and confocal fluorescence imaging of transgenic mouse brain tissue with a pixel dwell time of 20 µs. The fluorescence image visualizes neurons expressing yellow fluorescence proteins, while the photothermal signal detected endogenous chromophores in the mouse brain, allowing 3D visualization of the distribution of various features such as blood cells and fine structures most probably due to lipids. This imaging modality was constructed using compact and cost-effective laser diodes, and will thus be widely useful in the life and medical sciences. Third, we have made further resolution improvement of high-sensitivity laser scanning photothermal microscopy by applying non-linear detection. By this, the new method has super resolution with 61 and 42% enhancement from the diffraction limit values of the probe and pump wavelengths, respectively, by a second-order non-linear scheme and a high-frame rate in a laser scanning microscope. The maximum resolution is determined to be 160 nm in the second-order non-linear detection mode and 270 nm in the linear detection mode by the PT signal of GNPs. The pixel rate and frame rate for 300 × 300 pixel image are 50 µs and 4.5 s, respectively. The pixel and frame rate are shorter than the rates, those are 1 ms and 100 s, using the piezo-driven stage system.

Phase-detected Brillouin optical correlation-domain reflectometry

NASA Astrophysics Data System (ADS)

Mizuno, Yosuke; Hayashi, Neisei; Fukuda, Hideyuki; Nakamura, Kentaro

2018-05-01

Optical fiber sensing techniques based on Brillouin scattering have been extensively studied for structural health monitoring owing to their capability of distributed strain and temperature measurement. Although a higher signal-to-noise ratio (leading to high spatial resolution and high-speed measurement) is generally obtained for two-end-access systems, they reduce the degree of freedom in embedding the sensors into structures, and render the measurement no longer feasible when extremely high loss or breakage occurs at a point of the sensing fiber. To overcome these drawbacks, a one-end-access sensing technique called Brillouin optical correlation-domain reflectometry (BOCDR) has been developed. BOCDR has a high spatial resolution and cost efficiency, but its conventional configuration suffered from relatively low-speed operation. In this paper, we review the recently developed high-speed configurations of BOCDR, including phase-detected BOCDR, with which we demonstrate real-time distributed measurement by tracking a propagating mechanical wave. We also demonstrate breakage detection with a wide strain dynamic range.

Phase-detected Brillouin optical correlation-domain reflectometry

NASA Astrophysics Data System (ADS)

Mizuno, Yosuke; Hayashi, Neisei; Fukuda, Hideyuki; Nakamura, Kentaro

2018-06-01

Optical fiber sensing techniques based on Brillouin scattering have been extensively studied for structural health monitoring owing to their capability of distributed strain and temperature measurement. Although a higher signal-to-noise ratio (leading to high spatial resolution and high-speed measurement) is generally obtained for two-end-access systems, they reduce the degree of freedom in embedding the sensors into structures, and render the measurement no longer feasible when extremely high loss or breakage occurs at a point of the sensing fiber. To overcome these drawbacks, a one-end-access sensing technique called Brillouin optical correlation-domain reflectometry (BOCDR) has been developed. BOCDR has a high spatial resolution and cost efficiency, but its conventional configuration suffered from relatively low-speed operation. In this paper, we review the recently developed high-speed configurations of BOCDR, including phase-detected BOCDR, with which we demonstrate real-time distributed measurement by tracking a propagating mechanical wave. We also demonstrate breakage detection with a wide strain dynamic range.

Coherent dual-frequency lidar system design for distance and speed measurements

NASA Astrophysics Data System (ADS)

Zheng, Xingyuan; Zhao, Changming; Zhang, Haiyang; Zheng, Zheng; Yang, Hongzhi

2018-01-01

Lidars have a wide range of applications in military detection and civilian remote sensing. Coherent Dual-Frequency Lidar (CDFL) is a new concept of laser radar that is using electrical coherence instead of optical coherence. It uses laser with two coherent frequency components as transmitting wave. The method is based on the use of an optically-carried radio frequency (RF) signal, which is the frequency difference between the two components, which is specially designed for distance and speed measurements. It not only ensures the system has the characteristics of high spatial resolution, high ranging and velocity precision of laser radar, but also can use mature signal processing technology of microwave radar, and it is a research direction that attracts more concern in recent years. A CDFL detection system is constructed and field experiment is carried out. In the system, a narrow linewidth fiber laser with a wavelength of 1064nm is adopted. The dual-frequency laser with frequency difference of 200MHz and 200.6MHz is obtained by acousto-optic frequency shift and recombination. The maximum output power of dual frequency laser is 200mW. The receiver consists of all-fiber balanced InGaAs photo-detector and homemade analog signal processing board. The experimental results show that the distance resolution and velocity resolution of the system are 0.1m and 0.1m/s separately when the working distance is greater than 200m, and the spatial resolution is 0.5mrad.

Thin-film-based scintillators for hard x-ray microimaging detectors: the ScinTAX Project

NASA Astrophysics Data System (ADS)

Rack, A.; Cecilia, A.; Douissard, P.-A.; Dupré, K.; Wesemann, V.; Baumbach, T.; Couchaud, M.; Rochet, X.; Riesemeier, H.; Radtke, M.; Martin, T.

2014-09-01

The project ScinTAX developed novel thin scintillating films for the application in high performance X-ray imaging and subsequent introduced new X-ray detectors to the market. To achieve this aim lutetium orthosilicate (LSO) scintillators doped with different activators were grown successfully by liquid phase epitaxy. The high density of LSO (7.4 g/cm3), the effective atomic number (65.2) and the high light yield make this scintillator highly applicable for indirect X-ray detection in which the ionizing radiation is converted into visible light and then registered by a digital detector. A modular indirect detection system has been developed to fully exploit the potential of this thin film scintillator for radiographic and tomographic imaging. The system is compatible for high-resolution imaging with moderate dose as well as adaptable to intense high-dose applications where radiation hard microimaging detectors are required. This proceedings article shall review the achieved performances and technical details on this high-resolution detector system which is now available. A selected example application demonstrates the great potential of the optimized detector system for hard X-ray microimaging, i.e. either to improve image contrast due to the availability of efficient thin crystal films or to reduce the dose to the sample.

Improved Resolution Optical Time Stretch Imaging Based on High Efficiency In-Fiber Diffraction.

PubMed

Wang, Guoqing; Yan, Zhijun; Yang, Lei; Zhang, Lin; Wang, Chao

2018-01-12

Most overlooked challenges in ultrafast optical time stretch imaging (OTSI) are sacrificed spatial resolution and higher optical loss. These challenges are originated from optical diffraction devices used in OTSI, which encode image into spectra of ultrashort optical pulses. Conventional free-space diffraction gratings, as widely used in existing OTSI systems, suffer from several inherent drawbacks: limited diffraction efficiency in a non-Littrow configuration due to inherent zeroth-order reflection, high coupling loss between free-space gratings and optical fibers, bulky footprint, and more importantly, sacrificed imaging resolution due to non-full-aperture illumination for individual wavelengths. Here we report resolution-improved and diffraction-efficient OTSI using in-fiber diffraction for the first time to our knowledge. The key to overcome the existing challenges is a 45° tilted fiber grating (TFG), which serves as a compact in-fiber diffraction device offering improved diffraction efficiency (up to 97%), inherent compatibility with optical fibers, and improved imaging resolution owning to almost full-aperture illumination for all illumination wavelengths. 50 million frames per second imaging of fast moving object at 46 m/s with improved imaging resolution has been demonstrated. This conceptually new in-fiber diffraction design opens the way towards cost-effective, compact and high-resolution OTSI systems for image-based high-throughput detection and measurement.

A novel approach: high resolution inspection with wafer plane defect detection

NASA Astrophysics Data System (ADS)

Hess, Carl; Wihl, Mark; Shi, Rui-fang; Xiong, Yalin; Pang, Song

2008-05-01

High Resolution reticle inspection is well-established as a proven, effective, and efficient means of detecting yield-limiting mask defects as well as defects which are not immediately yield-limiting yet can enable manufacturing process improvements. Historically, RAPID products have enabled detection of both classes of these defects. The newly-developed Wafer Plane Inspection (WPI) detector technology meets the needs of some advanced mask manufacturers to identify the lithographically-significant defects while ignoring the other non-lithographically-significant defects. Wafer Plane Inspection accomplishes this goal by performing defect detection based on a modeled image of how the mask features would actually print in the photoresist. This has the effect of reducing sensitivity to non-printing defects while enabling higher sensitivity focused in high MEEF areas where small reticle defects still yield significant printing defects on wafers. WPI is a new inspection mode that has been developed by KLA-Tencor and is currently under test with multiple customers. It employs the same transmitted and reflected-light high-resolution images as the industry-standard high-resolution inspections, but with much more sophisticated processing involved. A rigorous mask pattern recovery algorithm is used to convert the transmitted and reflected light images into a modeled representation of the reticle. Lithographic modeling of the scanner is then used to generate an aerial image of the mask. This is followed by resist modeling to determine the exposure of the photoresist. The defect detectors are then applied on this photoresist plane so that only printing defects are detected. Note that no hardware modifications to the inspection system are required to enable this detector. The same tool will be able to perform both our standard High Resolution inspections and the Wafer Plane Inspection detector. This approach has several important features. The ability to ignore non-printing defects and to apply additional effective sensitivity in high MEEF areas enables advanced node development. In addition, the modeling allows the inclusion of important polarization effects that occur in the resist for high NA operation. This allows for the results to better match wafer print results compared to alternate approaches. Finally, the simulation easily allows for the application of arbitrary illumination profiles. With this approach, users of WPI can make use of unique or custom scanner illumination profiles. This allows the more precise modeling of profiles without inspection system hardware modification or loss of company intellectual property. This paper examines WPI in Die:Die mode. Future work includes a review of Die:Database WPI capability.

Detection of potato beetle damage using remote sensing from small unmanned aircraft systems

USDA-ARS?s Scientific Manuscript database

Remote sensing with small unmanned aircraft systems (sUAS) has potential applications in agriculture because low flight altitudes allow image acquisition at very high spatial resolution. We set up experiments at the Oregon State University Hermiston Agricultural Research and Extension Center (HAREC...

A TCAS-II Resolution Advisory Detection Algorithm

NASA Technical Reports Server (NTRS)

Munoz, Cesar; Narkawicz, Anthony; Chamberlain, James

2013-01-01

The Traffic Alert and Collision Avoidance System (TCAS) is a family of airborne systems designed to reduce the risk of mid-air collisions between aircraft. TCASII, the current generation of TCAS devices, provides resolution advisories that direct pilots to maintain or increase vertical separation when aircraft distance and time parameters are beyond designed system thresholds. This paper presents a mathematical model of the TCASII Resolution Advisory (RA) logic that assumes accurate aircraft state information. Based on this model, an algorithm for RA detection is also presented. This algorithm is analogous to a conflict detection algorithm, but instead of predicting loss of separation, it predicts resolution advisories. It has been formally verified that for a kinematic model of aircraft trajectories, this algorithm completely and correctly characterizes all encounter geometries between two aircraft that lead to a resolution advisory within a given lookahead time interval. The RA detection algorithm proposed in this paper is a fundamental component of a NASA sense and avoid concept for the integration of Unmanned Aircraft Systems in civil airspace.

Recent Developments in PET Instrumentation

PubMed Central

Peng, Hao; Levin, Craig S.

2013-01-01

Positron emission tomography (PET) is used in the clinic and in vivo small animal research to study molecular processes associated with diseases such as cancer, heart disease, and neurological disorders, and to guide the discovery and development of new treatments. This paper reviews current challenges of advancing PET technology and some of newly developed PET detectors and systems. The paper focuses on four aspects of PET instrumentation: high photon detection sensitivity; improved spatial resolution; depth-of-interaction (DOI) resolution and time-of-flight (TOF). Improved system geometry, novel non-scintillator based detectors, and tapered scintillation crystal arrays are able to enhance the photon detection sensitivity of a PET system. Several challenges for achieving high resolution with standard scintillator-based PET detectors are discussed. Novel detectors with 3-D positioning capability have great potential to be deployed in PET for achieving spatial resolution better than 1 mm, such as cadmium-zinc-telluride (CZT) and position-sensitive avalanche photodiodes (PSAPDs). DOI capability enables a PET system to mitigate parallax error and achieve uniform spatial resolution across the field-of-view (FOV). Six common DOI designs, as well as advantages and limitations of each design, are discussed. The availability of fast scintillation crystals such as LaBr3, and the silicon photomultiplier (SiPM) greatly advances TOF-PET development. Recent instrumentation and initial results of clinical trials are briefly presented. If successful, these technology advances, together with new probe molecules, will substantially enhance the molecular sensitivity of PET and thus increase its role in preclinical and clinical research as well as evaluating and managing disease in the clinic. PMID:20497121

Proposed tethered unmanned aerial system for the detection of pollution entering the Chesapeake Bay area

NASA Astrophysics Data System (ADS)

Goodman, J.; McKay, J.; Evans, W.; Gadsden, S. Andrew

2016-05-01

This paper is based on a proposed unmanned aerial system platform that is to be outfitted with high-resolution sensors. The proposed system is to be tethered to a moveable ground station, which may be a research vessel or some form of ground vehicle (e.g., car, truck, or rover). The sensors include, at a minimum: camera, infrared sensor, thermal, normalized difference vegetation index (NDVI) camera, global positioning system (GPS), and a light-based radar (LIDAR). The purpose of this paper is to provide an overview of existing methods for pollution detection of failing septic systems, and to introduce the proposed system. Future work will look at the high-resolution data from the sensors and integrating the data through a process called information fusion. Typically, this process is done using the popular and well-published Kalman filter (or its nonlinear formulations, such as the extended Kalman filter). However, future work will look at using a new type of strategy based on variable structure estimation for the information fusion portion of the data processing. It is hypothesized that fusing data from the thermal and NDVI sensors will be more accurate and reliable for a multitude of applications, including the detection of pollution entering the Chesapeake Bay area.

A three-wavelength multi-channel brain functional imager based on digital lock-in photon-counting technique

NASA Astrophysics Data System (ADS)

Ding, Xuemei; Wang, Bingyuan; Liu, Dongyuan; Zhang, Yao; He, Jie; Zhao, Huijuan; Gao, Feng

2018-02-01

During the past two decades there has been a dramatic rise in the use of functional near-infrared spectroscopy (fNIRS) as a neuroimaging technique in cognitive neuroscience research. Diffuse optical tomography (DOT) and optical topography (OT) can be employed as the optical imaging techniques for brain activity investigation. However, most current imagers with analogue detection are limited by sensitivity and dynamic range. Although photon-counting detection can significantly improve detection sensitivity, the intrinsic nature of sequential excitations reduces temporal resolution. To improve temporal resolution, sensitivity and dynamic range, we develop a multi-channel continuous-wave (CW) system for brain functional imaging based on a novel lock-in photon-counting technique. The system consists of 60 Light-emitting device (LED) sources at three wavelengths of 660nm, 780nm and 830nm, which are modulated by current-stabilized square-wave signals at different frequencies, and 12 photomultiplier tubes (PMT) based on lock-in photon-counting technique. This design combines the ultra-high sensitivity of the photon-counting technique with the parallelism of the digital lock-in technique. We can therefore acquire the diffused light intensity for all the source-detector pairs (SD-pairs) in parallel. The performance assessments of the system are conducted using phantom experiments, and demonstrate its excellent measurement linearity, negligible inter-channel crosstalk, strong noise robustness and high temporal resolution.

Research on the underwater target imaging based on the streak tube laser lidar

NASA Astrophysics Data System (ADS)

Cui, Zihao; Tian, Zhaoshuo; Zhang, Yanchao; Bi, Zongjie; Yang, Gang; Gu, Erdan

2018-03-01

A high frame rate streak tube imaging lidar (STIL) for real-time 3D imaging of underwater targets is presented in this paper. The system uses 532nm pulse laser as the light source, the maximum repetition rate is 120Hz, and the pulse width is 8ns. LabVIEW platform is used in the system, the system control, synchronous image acquisition, 3D data processing and display are realized through PC. 3D imaging experiment of underwater target is carried out in a flume with attenuation coefficient of 0.2, and the images of different depth and different material targets are obtained, the imaging frame rate is 100Hz, and the maximum detection depth is 31m. For an underwater target with a distance of 22m, the high resolution 3D image real-time acquisition is realized with range resolution of 1cm and space resolution of 0.3cm, the spatial relationship of the targets can be clearly identified by the image. The experimental results show that STIL has a good application prospect in underwater terrain detection, underwater search and rescue, and other fields.

Energy Resolution and Temperature Dependence of Ce:GAGG Coupled to 3mm × 3mm Silicon Photomultipliers

NASA Astrophysics Data System (ADS)

Seitz, B.; Rivera, N. Campos; Stewart, A. G.

2016-04-01

Scintillators are a critical component of sensor systems for the detection of ionizing radiation. Such systems have a diverse portfolio of applications from medical imaging, well logging in oil exploration, and detection systems for the prevention of the illicit movement of nuclear materials. The rare earth element cerium is an ideal dopant for a variety of host scintillating materials due to the fast 5d1 → 4f radiative transition of Ce3+. Cerium-doped gadolinium aluminium gallium garnet (Ce:GAGG) is a relatively new single crystal scintillator with several interesting properties. These include high light yield, an emission peak well-matched to silicon sensors, and low intrinsic energy resolution. Moreover, the material has high density and is nonhygroscopic. In this paper, we review the properties of cerium-doped GAGG and report energy-resolution (ER) measurements over the temperature range -10°C to +50°C for 3 × 3 × 30 mm3 Ce:GAGG crystals optically coupled to a silicon photomultipler (SiPM) sensor with a 3 mm × 3 mm active area. In addition, the linearity of the scintillator-SiPM response as a function of gamma energy is reported.

High resolution FTIR imaging provides automated discrimination and detection of single malaria parasite infected erythrocytes on glass.

PubMed

Perez-Guaita, David; Andrew, Dean; Heraud, Philip; Beeson, James; Anderson, David; Richards, Jack; Wood, Bayden R

2016-06-23

New highly sensitive tools for malaria diagnostics are urgently needed to enable the detection of infection in asymptomatic carriers and patients with low parasitemia. In pursuit of a highly sensitive diagnostic tool that can identify parasite infections at the single cell level, we have been exploring Fourier transform infrared (FTIR) microscopy using a Focal Plane Array (FPA) imaging detector. Here we report for the first time the application of a new optic configuration developed by Agilent that incorporates 25× condenser and objective Cassegrain optics with a high numerical aperture (NA = 0.81) along with additional high magnification optics within the microscope to provide 0.66 micron pixel resolution (total IR system magnification of 61×) to diagnose malaria parasites at the single cell level on a conventional glass microscope slide. The high quality images clearly resolve the parasite's digestive vacuole demonstrating sub-cellular resolution using this approach. Moreover, we have developed an algorithm that first detects the cells in the infrared image, and secondly extracts the average spectrum. The average spectrum is then run through a model based on Partial Least Squares-Discriminant Analysis (PLS-DA), which diagnoses unequivocally the infected from normal cells. The high quality images, and the fact this measurement can be achieved without a synchrotron source on a conventional glass slide, shows promise as a potential gold standard for malaria detection at the single cell level.

High Resolution PET Imaging Probe for the Detection, Molecular Characterization and Treatment Monitoring of Prostate Cancer

DTIC Science & Technology

2012-07-01

number of high resolution PET experiments including the dual-ring small field- of-view configuration shown at left in Figure 5 . The benchtop system...detectors having 26 x 40 arrays of 1mm x 1mm x 1mm detector elements is shown at right in Figure 5 . Detectors used for probe experiments shown in...Figure 13). In the series of experiments geared towards PET application, but with the results applicable to the present single gamma case, we have

Integrated High Resolution Digital Color Light Sensor in 130 nm CMOS Technology

PubMed Central

Strle, Drago; Nahtigal, Uroš; Batistell, Graciele; Zhang, Vincent Chi; Ofner, Erwin; Fant, Andrea; Sturm, Johannes

2015-01-01

This article presents a color light detection system integrated in 130 nm CMOS technology. The sensors and corresponding electronics detect light in a CIE XYZ color luminosity space using on-chip integrated sensors without any additional process steps, high-resolution analog-to-digital converter, and dedicated DSP algorithm. The sensor consists of a set of laterally arranged integrated photodiodes that are partly covered by metal, where color separation between the photodiodes is achieved by lateral carrier diffusion together with wavelength-dependent absorption. A high resolution, hybrid, ∑∆ ADC converts each photo diode’s current into a 22-bit digital result, canceling the dark current of the photo diodes. The digital results are further processed by the DSP, which calculates normalized XYZ or RGB color and intensity parameters using linear transformations of the three photo diode responses by multiplication of the data with a transformation matrix, where the coefficients are extracted by training in combination with a pseudo-inverse operation and the least-mean square approximation. The sensor system detects the color light parameters with 22-bit accuracy, consumes less than 60 μA on average at 10 readings per second, and occupies approx. 0.8 mm2 of silicon area (including three photodiodes and the analog part of the ADC). The DSP is currently implemented on FPGA. PMID:26205275

Particle swarm optimization method for small retinal vessels detection on multiresolution fundus images.

PubMed

Khomri, Bilal; Christodoulidis, Argyrios; Djerou, Leila; Babahenini, Mohamed Chaouki; Cheriet, Farida

2018-05-01

Retinal vessel segmentation plays an important role in the diagnosis of eye diseases and is considered as one of the most challenging tasks in computer-aided diagnosis (CAD) systems. The main goal of this study was to propose a method for blood-vessel segmentation that could deal with the problem of detecting vessels of varying diameters in high- and low-resolution fundus images. We proposed to use the particle swarm optimization (PSO) algorithm to improve the multiscale line detection (MSLD) method. The PSO algorithm was applied to find the best arrangement of scales in the MSLD method and to handle the problem of multiscale response recombination. The performance of the proposed method was evaluated on two low-resolution (DRIVE and STARE) and one high-resolution fundus (HRF) image datasets. The data include healthy (H) and diabetic retinopathy (DR) cases. The proposed approach improved the sensitivity rate against the MSLD by 4.7% for the DRIVE dataset and by 1.8% for the STARE dataset. For the high-resolution dataset, the proposed approach achieved 87.09% sensitivity rate, whereas the MSLD method achieves 82.58% sensitivity rate at the same specificity level. When only the smallest vessels were considered, the proposed approach improved the sensitivity rate by 11.02% and by 4.42% for the healthy and the diabetic cases, respectively. Integrating the proposed method in a comprehensive CAD system for DR screening would allow the reduction of false positives due to missed small vessels, misclassified as red lesions. (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE).

Handheld optical-resolution photoacoustic microscopy

NASA Astrophysics Data System (ADS)

Lin, Li; Zhang, Pengfei; Xu, Song; Shi, Junhui; Li, Lei; Yao, Junjie; Wang, Lidai; Zou, Jun; Wang, Lihong V.

2017-04-01

Optical-resolution photoacoustic microscopy (OR-PAM) offers label-free in vivo imaging with high spatial resolution by acoustically detecting optical absorption contrasts via the photoacoustic effect. We developed a compact handheld OR-PAM probe for fast photoacoustic imaging. Different from benchtop microscopes, the handheld probe provides flexibility in imaging various anatomical sites. Resembling a cup in size, the probe uses a two-axis water-immersible microelectromechanical system mirror to scan both the illuminating optical beam and resultant acoustic beam. The system performance was tested in vivo by imaging the capillary bed in a mouse ear and both the capillary bed and a mole on a human volunteer.

Quadrant anode image sensor

NASA Technical Reports Server (NTRS)

Lampton, M.; Malina, R. F.

1976-01-01

A position-sensitive event-counting electronic readout system for microchannel plates (MCPs) is described that offers the advantages of high spatial resolution and fast time resolution. The technique relies upon a four-quadrant electron-collecting anode located behind the output face of the microchannel plate, so that the electron cloud from each detected event is partly intercepted by each of the four quadrants. The relative amounts of charge collected by each quadrant depend on event position, permitting each event to be localized with two ratio circuits. A prototype quadrant anode system for ion, electron, and extreme ultraviolet imaging is described. The spatial resolution achieved, about 10 microns, allows individual MCP channels to be distinguished.

Insect detection and nitrogen management for irrigated potatoes using remote sensing from small unmanned aircraft systems

USDA-ARS?s Scientific Manuscript database

Remote sensing with small unmanned aircraft systems (sUAS) has potential applications in agriculture because low flight altitudes allow image acquisition at very high spatial resolution. We set up experiments at the Oregon State University Hermiston Agricultural Research and Extension Center with d...

Flexible feature-space-construction architecture and its VLSI implementation for multi-scale object detection

NASA Astrophysics Data System (ADS)

Luo, Aiwen; An, Fengwei; Zhang, Xiangyu; Chen, Lei; Huang, Zunkai; Jürgen Mattausch, Hans

2018-04-01

Feature extraction techniques are a cornerstone of object detection in computer-vision-based applications. The detection performance of vison-based detection systems is often degraded by, e.g., changes in the illumination intensity of the light source, foreground-background contrast variations or automatic gain control from the camera. In order to avoid such degradation effects, we present a block-based L1-norm-circuit architecture which is configurable for different image-cell sizes, cell-based feature descriptors and image resolutions according to customization parameters from the circuit input. The incorporated flexibility in both the image resolution and the cell size for multi-scale image pyramids leads to lower computational complexity and power consumption. Additionally, an object-detection prototype for performance evaluation in 65 nm CMOS implements the proposed L1-norm circuit together with a histogram of oriented gradients (HOG) descriptor and a support vector machine (SVM) classifier. The proposed parallel architecture with high hardware efficiency enables real-time processing, high detection robustness, small chip-core area as well as low power consumption for multi-scale object detection.

LITE microscopy: Tilted light-sheet excitation of model organisms offers high resolution and low photobleaching

PubMed Central

Gerbich, Therese M.; Rana, Kishan; Suzuki, Aussie; Schaefer, Kristina N.; Heppert, Jennifer K.; Boothby, Thomas C.; Allbritton, Nancy L.; Gladfelter, Amy S.; Maddox, Amy S.

2018-01-01

Fluorescence microscopy is a powerful approach for studying subcellular dynamics at high spatiotemporal resolution; however, conventional fluorescence microscopy techniques are light-intensive and introduce unnecessary photodamage. Light-sheet fluorescence microscopy (LSFM) mitigates these problems by selectively illuminating the focal plane of the detection objective by using orthogonal excitation. Orthogonal excitation requires geometries that physically limit the detection objective numerical aperture (NA), thereby limiting both light-gathering efficiency (brightness) and native spatial resolution. We present a novel live-cell LSFM method, lateral interference tilted excitation (LITE), in which a tilted light sheet illuminates the detection objective focal plane without a sterically limiting illumination scheme. LITE is thus compatible with any detection objective, including oil immersion, without an upper NA limit. LITE combines the low photodamage of LSFM with high resolution, high brightness, and coverslip-based objectives. We demonstrate the utility of LITE for imaging animal, fungal, and plant model organisms over many hours at high spatiotemporal resolution. PMID:29490939

A compact 45 kV curve tracer with picoampere current measurement capability.

PubMed

Sullivan, W W; Mauch, D; Bullick, A; Hettler, C; Neuber, A; Dickens, J

2013-03-01

This paper discusses a compact high voltage curve tracer for high voltage semiconductor device characterization. The system sources up to 3 mA at up to 45 kV in dc conditions. It measures from 328 V to 60 kV with 15 V resolution and from 9.4 pA to 4 mA with 100 fA minimum resolution. Control software for the system is written in Microsoft Visual C# and features real-time measurement control and IV plotting, arc-protection and detection, an electrically isolated universal serial bus interface, and easy data exporting capabilities. The system has survived numerous catastrophic high voltage device-under-test arcing failures with no loss of measurement capability or system damage. Overall sweep times are typically under 2 min, and the curve tracer system was used to characterize the blocking performance of high voltage ceramic capacitors, high voltage silicon carbide photoconductive semiconductor switches, and high voltage coaxial cable.

Geo-PET: A novel generic organ-pet for small animal organs and tissues

NASA Astrophysics Data System (ADS)

Sensoy, Levent

Reconstructed tomographic image resolution of small animal PET imaging systems is improving with advances in radiation detector development. However the trend towards higher resolution systems has come with an increase in price and system complexity. Recent developments in the area of solid-state photomultiplication devices like silicon photomultiplier arrays (SPMA) are creating opportunities for new high performance tools for PET scanner design. Imaging of excised small animal organs and tissues has been used as part of post-mortem studies in order to gain detailed, high-resolution anatomical information on sacrificed animals. However, this kind of ex-vivo specimen imaging has largely been limited to ultra-high resolution muCT. The inherent limitations to PET resolution have, to date, excluded PET imaging from these ex-vivo imaging studies. In this work, we leverage the diminishing physical size of current generation SPMA designs to create a very small, simple, and high-resolution prototype detector system targeting ex-vivo tomographic imaging of small animal organs and tissues. We investigate sensitivity, spatial resolution, and the reconstructed image quality of a prototype small animal PET scanner designed specifically for imaging of excised murine tissue and organs. We aim to demonstrate that a cost-effective silicon photomultiplier (SiPM) array based design with thin crystals (2 mm) to minimize depth of interaction errors might be able to achieve sub-millimeter resolution. We hypothesize that the substantial decrease in sensitivity associated with the thin crystals can be compensated for with increased solid angle detection, longer acquisitions, higher activity and wider acceptance energy windows (due to minimal scatter from excised organs). The constructed system has a functional field of view (FoV) of 40 mm diameter, which is adequate for most small animal specimen studies. We perform both analytical (3D-FBP) and iterative (ML-EM) methods in order to reconstruct tomographic images. Results demonstrate good agreement between the simulation and the prototype. Our detector system with pixelated crystals is able to separate small objects as close as 1.25 mm apart, whereas spatial resolution converges to the theoretical limit of 1.6 mm (half the size of the smallest detecting element), which is to comparable to the spatial resolution of the existing commercial small animal PET systems. Better system spatial resolution is achievable with new generation SiPM detector boards with 1 mm x 1 mm cell dimensions. We demonstrate through Monte Carlo simulations that it is possible to achieve sub-millimeter spatial image resolution (0.7 mm for our scanner) in complex objects using monolithic crystals and exploiting the light-sharing mechanism among the neighboring detector cells. Results also suggest that scanner (or object) rotation minimizes artifacts arising from poor angular sampling, which is even more significant in smaller PET designs as the gaps between the sensitive regions of the detector have a more exaggerated effect on the overall reconstructed image quality when the design is more compact. Sensitivity of the system, on the other hand, can be doubled by adding two additional detector heads resulting in a, fully closed, 4? geometry.

Self-Referenced Fiber Optic System For Remote Methane Detection

NASA Astrophysics Data System (ADS)

Zientkiewicz, Jacek K.

1989-10-01

The paper discusses a fiber optic multisensor methane detection system matched to topology and environment of the underground mine. The system involves time domain multiplexed (TDM) methane sensors based on selective absorption of source radiation by atomic/molecular species in the gas sensing heads. A two-wavelength ratiometric approach allows simple self-referencing, cancels out errors arising from other contaminants, and improves the measurement contrast. The laboratory system consists of a high radiance LED source, multimode fiber, optical sensing head, optical bandpass filters, and involves synchronous detection with low noise photodiodes and a lock-in amplifier. Detection sensitivity versus spectral resolution of the optical filters has also been investigated and described. The system performance was evaluated and the results are presented.

Microsecond resolved single-molecule FRET time series measurements based on the line confocal optical system combined with hybrid photodetectors.

PubMed

Oikawa, Hiroyuki; Takahashi, Takumi; Kamonprasertsuk, Supawich; Takahashi, Satoshi

2018-01-31

Single-molecule (sm) fluorescence time series measurements based on the line confocal optical system are a powerful strategy for the investigation of the structure, dynamics, and heterogeneity of biological macromolecules. This method enables the detection of more than several thousands of fluorescence photons per millisecond from single fluorophores, implying that the potential time resolution for measurements of the fluorescence resonance energy transfer (FRET) efficiency is 10 μs. However, the necessity of using imaging photodetectors in the method limits the time resolution in the FRET efficiency measurements to approximately 100 μs. In this investigation, a new photodetector called a hybrid photodetector (HPD) was incorporated into the line confocal system to improve the time resolution without sacrificing the length of the time series detection. Among several settings examined, the system based on a slit width of 10 μm and a high-speed counting device made the best of the features of the line confocal optical system and the HPD. This method achieved a time resolution of 10 μs and an observation time of approximately 5 ms in the sm-FRET time series measurements. The developed device was used for the native state of the B domain of protein A.

Development of a high-resolution cavity-beam position monitor

NASA Astrophysics Data System (ADS)

Inoue, Yoichi; Hayano, Hitoshi; Honda, Yosuke; Takatomi, Toshikazu; Tauchi, Toshiaki; Urakawa, Junji; Komamiya, Sachio; Nakamura, Tomoya; Sanuki, Tomoyuki; Kim, Eun-San; Shin, Seung-Hwan; Vogel, Vladimir

2008-06-01

We have developed a high-resolution cavity-beam position monitor (BPM) to be used at the focal point of the ATF2, which is a test beam line that is now being built to demonstrate stable orbit control at ˜nanometer resolution. The design of the cavity structure was optimized for the Accelerator Test Facility (ATF) beam in various ways. For example, the cavity has a rectangular shape in order to isolate two dipole modes in orthogonal directions, and a relatively thin gap that is less sensitive to trajectory inclination. A two stage homodyne mixer with highly sensitive electronics and phase-sensitive detection was also developed. Two BPM blocks, each containing two cavity BPMs, were installed in the existing ATF beam line using a rigid support frame. After testing the basic characteristics, we measured the resolution using three BPMs. The system demonstrated 8.7 nm position resolution over a dynamic range of 5μm.

High-Resolution Scintimammography: A Pilot Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rachel F. Brem; Joelle M. Schoonjans; Douglas A. Kieper

2002-07-01

This study evaluated a novel high-resolution breast-specific gamma camera (HRBGC) for the detection of suggestive breast lesions. Methods: Fifty patients (with 58 breast lesions) for whom a scintimammogram was clinically indicated were prospectively evaluated with a general-purpose gamma camera and a novel HRBGC prototype. The results of conventional and high-resolution nuclear studies were prospectively classified as negative (normal or benign) or positive (suggestive or malignant) by 2 radiologists who were unaware of the mammographic and histologic results. All of the included lesions were confirmed by pathology. Results: There were 30 benign and 28 malignant lesions. The sensitivity for detection ofmore » breast cancer was 64.3% (18/28) with the conventional camera and 78.6% (22/28) with the HRBGC. The specificity with both systems was 93.3% (28/30). For the 18 nonpalpable lesions, sensitivity was 55.5% (10/18) and 72.2% (13/18) with the general-purpose camera and the HRBGC, respectively. For lesions 1 cm, 7 of 15 were detected with the general-purpose camera and 10 of 15 with the HRBGC. Four lesions (median size, 8.5 mm) were detected only with the HRBGC and were missed by the conventional camera. Conclusion: Evaluation of indeterminate breast lesions with an HRBGC results in improved sensitivity for the detection of cancer, with greater improvement shown for nonpalpable and 1-cm lesions.« less

A common-path phase-shift interferometry surface plasmon imaging system

NASA Astrophysics Data System (ADS)

Su, Y.-T.; Chen, Shean-Jen; Yeh, T.-L.

2005-03-01

A biosensing imaging system is proposed based on the integration of surface plasmon resonance (SPR) and common-path phase-shift interferometry (PSI) techniques to measure the two-dimensional spatial phase variation caused by biomolecular interactions upon a sensing chip. The SPR phase imaging system can offer high resolution and high-throughout screening capabilities to analyze microarray biomolecular interaction without the need for additional labeling. With the long-term stability advantage of the common-path PSI technique even with external disturbances such as mechanical vibration, buffer flow noise, and laser unstable issue, the system can match the demand of real-time kinetic study for biomolecular interaction analysis (BIA). The SPR-PSI imaging system has achieved a detection limit of 2×10-7 refraction index change, a long-term phase stability of 2.5x10-4π rms over four hours, and a spatial phase resolution of 10-3 π with a lateral resolution of 100μm.

The optical frequency comb fibre spectrometer

PubMed Central

Coluccelli, Nicola; Cassinerio, Marco; Redding, Brandon; Cao, Hui; Laporta, Paolo; Galzerano, Gianluca

2016-01-01

Optical frequency comb sources provide thousands of precise and accurate optical lines in a single device enabling the broadband and high-speed detection required in many applications. A main challenge is to parallelize the detection over the widest possible band while bringing the resolution to the single comb-line level. Here we propose a solution based on the combination of a frequency comb source and a fibre spectrometer, exploiting all-fibre technology. Our system allows for simultaneous measurement of 500 isolated comb lines over a span of 0.12 THz in a single acquisition; arbitrarily larger span are demonstrated (3,500 comb lines over 0.85 THz) by doing sequential acquisitions. The potential for precision measurements is proved by spectroscopy of acetylene at 1.53 μm. Being based on all-fibre technology, our system is inherently low-cost, lightweight and may lead to the development of a new class of broadband high-resolution spectrometers. PMID:27694981

Nano-Mole Scale Side-Chain Signal Assignment by 1H-Detected Protein Solid-State NMR by Ultra-Fast Magic-Angle Spinning and Stereo-Array Isotope Labeling

PubMed Central

Nishiyama, Yusuke; Endo, Yuki; Nemoto, Takahiro; Yamauchi, Kazuo; Asakura, Tetsuo; Takeda, Mitsuhiro; Terauchi, Tsutomu; Kainosho, Masatsune; Ishii, Yoshitaka

2015-01-01

We present a general approach in 1H-detected 13C solid-state NMR (SSNMR) for side-chain signal assignments of 10-50 nmol quantities of proteins using a combination of a high magnetic field, ultra-fast magic-angle spinning (MAS) at ~80 kHz, and stereo-array-isotope-labeled (SAIL) proteins [Kainosho M. et al., Nature 440, 52–57, 2006]. First, we demonstrate that 1H indirect detection improves the sensitivity and resolution of 13C SSNMR of SAIL proteins for side-chain assignments in the ultra-fast MAS condition. 1H-detected SSNMR was performed for micro-crystalline ubiquitin (~55 nmol or ~0.5mg) that was SAIL-labeled at seven isoleucine (Ile) residues. Sensitivity was dramatically improved by 1H-detected 2D 1H/13C SSNMR by factors of 5.4-9.7 and 2.1-5.0, respectively, over 13C-detected 2D 1H/13C SSNMR and 1D 13C CPMAS, demonstrating that 2D 1H-detected SSNMR offers not only additional resolution but also sensitivity advantage over 1D 13C detection for the first time. High 1H resolution for the SAIL-labeled side-chain residues offered reasonable resolution even in the 2D data. A 1H-detected 3D 13C/13C/1H experiment on SAIL-ubiquitin provided nearly complete 1H and 13C assignments for seven Ile residues only within ~2.5 h. The results demonstrate the feasibility of side-chain signal assignment in this approach for as little as 10 nmol of a protein sample within ~3 days. The approach is likely applicable to a variety of proteins of biological interest without any requirements of highly efficient protein expression systems. PMID:25856081

Ultrahigh resolution radiation imaging system using an optical fiber structure scintillator plate.

PubMed

Yamamoto, Seiichi; Kamada, Kei; Yoshikawa, Akira

2018-02-16

High resolution imaging of radiation is required for such radioisotope distribution measurements as alpha particle detection in nuclear facilities or high energy physics experiments. For this purpose, we developed an ultrahigh resolution radiation imaging system using an optical fiber structure scintillator plate. We used a ~1-μm diameter fiber structured GdAlO 3 :Ce (GAP) /α-Al 2 O 3 scintillator plate to reduce the light spread. The fiber structured scintillator plate was optically coupled to a tapered optical fiber plate to magnify the image and combined with a lens-based high sensitivity CCD camera. We observed the images of alpha particles with a spatial resolution of ~25 μm. For the beta particles, the images had various shapes, and the trajectories of the electrons were clearly observed in the images. For the gamma photons, the images also had various shapes, and the trajectories of the secondary electrons were observed in some of the images. These results show that combining an optical fiber structure scintillator plate with a tapered optical fiber plate and a high sensitivity CCD camera achieved ultrahigh resolution and is a promising method to observe the images of the interactions of radiation in a scintillator.

High-resolution three-dimensional imaging with compress sensing

NASA Astrophysics Data System (ADS)

Wang, Jingyi; Ke, Jun

2016-10-01

LIDAR three-dimensional imaging technology have been used in many fields, such as military detection. However, LIDAR require extremely fast data acquisition speed. This makes the manufacture of detector array for LIDAR system is very difficult. To solve this problem, we consider using compress sensing which can greatly decrease the data acquisition and relax the requirement of a detection device. To use the compressive sensing idea, a spatial light modulator will be used to modulate the pulsed light source. Then a photodetector is used to receive the reflected light. A convex optimization problem is solved to reconstruct the 2D depth map of the object. To improve the resolution in transversal direction, we use multiframe image restoration technology. For each 2D piecewise-planar scene, we move the SLM half-pixel each time. Then the position where the modulated light illuminates will changed accordingly. We repeat moving the SLM to four different directions. Then we can get four low-resolution depth maps with different details of the same plane scene. If we use all of the measurements obtained by the subpixel movements, we can reconstruct a high-resolution depth map of the sense. A linear minimum-mean-square error algorithm is used for the reconstruction. By combining compress sensing and multiframe image restoration technology, we reduce the burden on data analyze and improve the efficiency of detection. More importantly, we obtain high-resolution depth maps of a 3D scene.

High-resolution remote sensing of water quality in the San Francisco Bay-Delta Estuary

USGS Publications Warehouse

Fichot, Cédric G.; Downing, Bryan D.; Bergamaschi, Brian; Windham-Myers, Lisamarie; Marvin-DiPasquale, Mark C.; Thompson, David R.; Gierach, Michelle M.

2015-01-01

The San Francisco Bay–Delta Estuary watershed is a major source of freshwater for California and a profoundly human-impacted environment. The water quality monitoring that is critical to the management of this important water resource and ecosystem relies primarily on a system of fixed water-quality monitoring stations, but the limited spatial coverage often hinders understanding. Here, we show how the latest technology in visible/near-infrared imaging spectroscopy can facilitate water quality monitoring in this highly dynamic and heterogeneous system by enabling simultaneous depictions of several water quality indicators at very high spatial resolution. The airborne portable remote imaging spectrometer (PRISM) was used to derive high-spatial-resolution (2.6 × 2.6 m) distributions of turbidity, and dissolved organic carbon (DOC) and chlorophyll-a concentrations in a wetland-influenced region of this estuary. A filter-passing methylmercury vs DOC relationship was also developed using in situ samples and enabled the high-spatial-resolution depiction of surface methylmercury concentrations in this area. The results illustrate how high-resolution imaging spectroscopy can inform management and policy development in important inland and estuarine water bodies by facilitating the detection of point- and nonpoint-source pollution, and by providing data to help assess the complex impacts of wetland restoration and climate change on water quality and ecosystem productivity.

Monitoring Termite-Mediated Ecosystem Processes Using Moderate and High Resolution Satellite Imagery

NASA Astrophysics Data System (ADS)

Lind, B. M.; Hanan, N. P.

2016-12-01

Termites are considered dominant decomposers and prominent ecosystem engineers in the global tropics and they build some of the largest and architecturally most complex non-human-made structures in the world. Termite mounds significantly alter soil texture, structure, and nutrients, and have major implications for local hydrological dynamics, vegetation characteristics, and biological diversity. An understanding of how these processes change across large scales has been limited by our ability to detect termite mounds at high spatial resolutions. Our research develops methods to detect large termite mounds in savannas across extensive geographic areas using moderate and high resolution satellite imagery. We also investigate the effect of termite mounds on vegetation productivity using Landsat-8 maximum composite NDVI data as a proxy for production. Large termite mounds in arid and semi-arid Senegal generate highly reflective `mound scars' with diameters ranging from 10 m at minimum to greater than 30 m. As Sentinel-2 has several bands with 10 m resolution and Landsat-8 has improved calibration, higher radiometric resolution, 15 m spatial resolution (pansharpened), and improved contrast between vegetated and bare surfaces compared to previous Landsat missions, we found that the largest and most influential mounds in the landscape can be detected. Because mounds as small as 4 m in diameter are easily detected in high resolution imagery we used these data to validate detection results and quantify omission errors for smaller mounds.

High Resolution Trichromatic Road Surface Scanning with a Line Scan Camera and Light Emitting Diode Lighting for Road-Kill Detection.

PubMed

Lopes, Gil; Ribeiro, A Fernando; Sillero, Neftalí; Gonçalves-Seco, Luís; Silva, Cristiano; Franch, Marc; Trigueiros, Paulo

2016-04-19

This paper presents a road surface scanning system that operates with a trichromatic line scan camera with light emitting diode (LED) lighting achieving road surface resolution under a millimeter. It was part of a project named Roadkills-Intelligent systems for surveying mortality of amphibians in Portuguese roads, sponsored by the Portuguese Science and Technology Foundation. A trailer was developed in order to accommodate the complete system with standalone power generation, computer image capture and recording, controlled lighting to operate day or night without disturbance, incremental encoder with 5000 pulses per revolution attached to one of the trailer wheels, under a meter Global Positioning System (GPS) localization, easy to utilize with any vehicle with a trailer towing system and focused on a complete low cost solution. The paper describes the system architecture of the developed prototype, its calibration procedure, the performed experimentation and some obtained results, along with a discussion and comparison with existing systems. Sustained operating trailer speeds of up to 30 km/h are achievable without loss of quality at 4096 pixels' image width (1 m width of road surface) with 250 µm/pixel resolution. Higher scanning speeds can be achieved by lowering the image resolution (120 km/h with 1 mm/pixel). Computer vision algorithms are under development to operate on the captured images in order to automatically detect road-kills of amphibians.

High Resolution Trichromatic Road Surface Scanning with a Line Scan Camera and Light Emitting Diode Lighting for Road-Kill Detection

PubMed Central

Lopes, Gil; Ribeiro, A. Fernando; Sillero, Neftalí; Gonçalves-Seco, Luís; Silva, Cristiano; Franch, Marc; Trigueiros, Paulo

2016-01-01

This paper presents a road surface scanning system that operates with a trichromatic line scan camera with light emitting diode (LED) lighting achieving road surface resolution under a millimeter. It was part of a project named Roadkills—Intelligent systems for surveying mortality of amphibians in Portuguese roads, sponsored by the Portuguese Science and Technology Foundation. A trailer was developed in order to accommodate the complete system with standalone power generation, computer image capture and recording, controlled lighting to operate day or night without disturbance, incremental encoder with 5000 pulses per revolution attached to one of the trailer wheels, under a meter Global Positioning System (GPS) localization, easy to utilize with any vehicle with a trailer towing system and focused on a complete low cost solution. The paper describes the system architecture of the developed prototype, its calibration procedure, the performed experimentation and some obtained results, along with a discussion and comparison with existing systems. Sustained operating trailer speeds of up to 30 km/h are achievable without loss of quality at 4096 pixels’ image width (1 m width of road surface) with 250 µm/pixel resolution. Higher scanning speeds can be achieved by lowering the image resolution (120 km/h with 1 mm/pixel). Computer vision algorithms are under development to operate on the captured images in order to automatically detect road-kills of amphibians. PMID:27104535

Design criteria for a high energy Compton Camera and possible application to targeted cancer therapy

NASA Astrophysics Data System (ADS)

Conka Nurdan, T.; Nurdan, K.; Brill, A. B.; Walenta, A. H.

2015-07-01

The proposed research focuses on the design criteria for a Compton Camera with high spatial resolution and sensitivity, operating at high gamma energies and its possible application for molecular imaging. This application is mainly on the detection and visualization of the pharmacokinetics of tumor targeting substances specific for particular cancer sites. Expected high resolution (< 0.5 mm) permits monitoring the pharmacokinetics of labeled gene constructs in vivo in small animals with a human tumor xenograft which is one of the first steps in evaluating the potential utility of a candidate gene. The additional benefit of high sensitivity detection will be improved cancer treatment strategies in patients based on the use of specific molecules binding to cancer sites for early detection of tumors and identifying metastasis, monitoring drug delivery and radionuclide therapy for optimum cell killing at the tumor site. This new technology can provide high resolution, high sensitivity imaging of a wide range of gamma energies and will significantly extend the range of radiotracers that can be investigated and used clinically. The small and compact construction of the proposed camera system allows flexible application which will be particularly useful for monitoring residual tumor around the resection site during surgery. It is also envisaged as able to test the performance of new drug/gene-based therapies in vitro and in vivo for tumor targeting efficacy using automatic large scale screening methods.

Development of a Si-PM based alpha camera for plutonium detection in nuclear fuel facilities

NASA Astrophysics Data System (ADS)

Morishita, Yuki; Yamamoto, Seiichi; Izaki, Kenji; Kaneko, Junichi H.; Toi, Kohei; Tsubota, Youichi

2014-05-01

Alpha particles are monitored for detecting nuclear fuel material (i.e., plutonium and uranium) at nuclear fuel facilities. Currently, for monitoring the airborne contamination of nuclear fuel, only energy information measured by Si-semiconductor detectors is used to distinguish nuclear fuel material from radon daughters. In some cases, however, such distinguishing is difficult when the radon concentration is high. In addition, a Si-semiconductor detector is generally sensitive to noise. In this study, we developed a new alpha-particle imaging system by combining a Si-PM array, which is insensitive to noise, with a Ce-doped Gd3Al2Ga3O12(GAGG) scintillator, and evaluated our developed system's fundamental performance. The scintillator was 0.1-mm thick, and the light guide was 3.0 mm thick. An 241Am source was used for all the measurements. We evaluated the spatial resolution by taking an image of a resolution chart. A 1.6 lp/mm slit was clearly resolved, and the spatial resolution was estimated to be less than 0.6-mm FWHM. The energy resolution was 13% FWHM. A slight distortion was observed in the image, and the uniformity near its center was within ±24%. We conclude that our developed alpha-particle imaging system is promising for plutonium detection at nuclear fuel facilities.

Machine Learning Based Single-Frame Super-Resolution Processing for Lensless Blood Cell Counting

PubMed Central

Huang, Xiwei; Jiang, Yu; Liu, Xu; Xu, Hang; Han, Zhi; Rong, Hailong; Yang, Haiping; Yan, Mei; Yu, Hao

2016-01-01

A lensless blood cell counting system integrating microfluidic channel and a complementary metal oxide semiconductor (CMOS) image sensor is a promising technique to miniaturize the conventional optical lens based imaging system for point-of-care testing (POCT). However, such a system has limited resolution, making it imperative to improve resolution from the system-level using super-resolution (SR) processing. Yet, how to improve resolution towards better cell detection and recognition with low cost of processing resources and without degrading system throughput is still a challenge. In this article, two machine learning based single-frame SR processing types are proposed and compared for lensless blood cell counting, namely the Extreme Learning Machine based SR (ELMSR) and Convolutional Neural Network based SR (CNNSR). Moreover, lensless blood cell counting prototypes using commercial CMOS image sensors and custom designed backside-illuminated CMOS image sensors are demonstrated with ELMSR and CNNSR. When one captured low-resolution lensless cell image is input, an improved high-resolution cell image will be output. The experimental results show that the cell resolution is improved by 4×, and CNNSR has 9.5% improvement over the ELMSR on resolution enhancing performance. The cell counting results also match well with a commercial flow cytometer. Such ELMSR and CNNSR therefore have the potential for efficient resolution improvement in lensless blood cell counting systems towards POCT applications. PMID:27827837

Vernal Pools Detection Using High-Resolution LiDAR Data and Aerial Imagery in Hubbardston, Massachusetts

NASA Astrophysics Data System (ADS)

Jiang, Jiaxin

Vernal pool refers to temporary or semi-permanent pools that occur in surface depressions without permanent inlets or outlets. Because they periodically dry out, vernal pools are free of fish and essential to amphibians, some reptiles, birds, and mammals for breeding habitats. In Massachusetts, vernal pool habitats are found in woodland depressions, swales or kettle holes where water is contained for at least two months in most years. However, vernal pools are delicate ecosystems. These systems are fragile to human activities such as urbanization. Understanding the current situation of vernal pools helps city planners make wiser decisions. This study focuses on identifying vernal pools in the state of Massachusetts with high-resolution light detection and ranging (LiDAR) data and aerial imagery. By using high-resolution light detection and ranging data, aerial imagery, land use data, the MassDEP Hydrography layer and the Soil Survey Geographic Database, the approach located over 1800 potential vernal pools in a 108 km 2 study area in Massachusetts. The assessment of the study result shows the commission rate was 5.6% and omission rate was 7.1%. This method provides an efficient way of locating vernal pools over large areas.

The characterization of an economic and portable LED-based photoacoustic imaging system to facilitate molecular imaging.

PubMed

Hariri, Ali; Lemaster, Jeanne; Wang, Junxin; Jeevarathinam, AnanthaKrishnan S; Chao, Daniel L; Jokerst, Jesse V

2018-03-01

Photoacoustic imaging (PAI) is a non-invasive, high-resolution hybrid imaging modality that combines optical excitation and ultrasound detection. PAI can image endogenous chromophores (melanin, hemoglobin, etc.) and exogenous contrast agents in different medical applications. However, most current equipment uses sophisticated and complicated OPO lasers with tuning and stability features inconsistent with broad clinical deployment. As the number of applications of PAI in medicine increases, there is an urgent need to make the imaging equipment more compact, portable, and affordable. Here, portable light emitting diode - based photoacoustic imaging (PLED-PAI) was introduced and characterized in terms of system specifications, light source characterizations, photoacoustic spatial/temporal resolution, and penetration. The system uses two LED arrays attached to the sides of a conventional ultrasound transducer. The LED pulse repetition rate is tunable between 1 K Hz, 2 K Hz, 3 K Hz, and 4 K Hz. The axial resolution was 0.268 mm, and the lateral resolution was between 0.55 and 0.59 mm. The system could detect optical absorber (pencil lead) at a depth of 3.2 cm and the detection limits of indocyanine green (ICG) and methylene blue (MB) were 9 μM and 0.78 mM. In vivo imaging of labeled human mesenchymal stem cells was achieved to confirm compatibility with small animal imaging. The characterization we report here may have value to other groups evaluating commercially available photoacoustic imaging equipment.

Detection of potato beetle damage using remote sensing from small unmanned aircraft systems

NASA Astrophysics Data System (ADS)

Hunt, E. Raymond; Rondon, Silvia I.

2017-04-01

Colorado potato beetle (CPB) adults and larvae devour leaves of potato and other solanaceous crops and weeds, and may quickly develop resistance to pesticides. With early detection of CPB damage, more options are available for precision integrated pest management, which reduces the amount of pesticides applied in a field. Remote sensing with small unmanned aircraft systems (sUAS) has potential for CPB detection because low flight altitudes allow image acquisition at very high spatial resolution. A five-band multispectral sensor and up-looking incident light sensor were mounted on a six-rotor sUAS, which was flown at altitudes of 60 and 30 m in June 2014. Plants went from visibly undamaged to having some damage in just 1 day. Whole-plot normalized difference vegetation index (NDVI) and the number of pixels classified as damaged (0.70≤NDVI≤0.80) were not correlated with visible CPB damage ranked from least to most. Area of CPB damage estimated using object-based image analysis was highly correlated to the visual ranking of damage. Furthermore, plant height calculated using structure-from-motion point clouds was related to CPB damage, but this method required extensive operator intervention for success. Object-based image analysis has potential for early detection based on high spatial resolution sUAS remote sensing.

Point target detection utilizing super-resolution strategy for infrared scanning oversampling system

NASA Astrophysics Data System (ADS)

Wang, Longguang; Lin, Zaiping; Deng, Xinpu; An, Wei

2017-11-01

To improve the resolution of remote sensing infrared images, infrared scanning oversampling system is employed with information amount quadrupled, which contributes to the target detection. Generally the image data from double-line detector of infrared scanning oversampling system is shuffled to a whole oversampled image to be post-processed, whereas the aliasing between neighboring pixels leads to image degradation with a great impact on target detection. This paper formulates a point target detection method utilizing super-resolution (SR) strategy concerning infrared scanning oversampling system, with an accelerated SR strategy proposed to realize fast de-aliasing of the oversampled image and an adaptive MRF-based regularization designed to achieve the preserving and aggregation of target energy. Extensive experiments demonstrate the superior detection performance, robustness and efficiency of the proposed method compared with other state-of-the-art approaches.

Automatic landslide detection from LiDAR DTM derivatives by geographic-object-based image analysis based on open-source software

NASA Astrophysics Data System (ADS)

Knevels, Raphael; Leopold, Philip; Petschko, Helene

2017-04-01

With high-resolution airborne Light Detection and Ranging (LiDAR) data more commonly available, many studies have been performed to facilitate the detailed information on the earth surface and to analyse its limitation. Specifically in the field of natural hazards, digital terrain models (DTM) have been used to map hazardous processes such as landslides mainly by visual interpretation of LiDAR DTM derivatives. However, new approaches are striving towards automatic detection of landslides to speed up the process of generating landslide inventories. These studies usually use a combination of optical imagery and terrain data, and are designed in commercial software packages such as ESRI ArcGIS, Definiens eCognition, or MathWorks MATLAB. The objective of this study was to investigate the potential of open-source software for automatic landslide detection based only on high-resolution LiDAR DTM derivatives in a study area within the federal state of Burgenland, Austria. The study area is very prone to landslides which have been mapped with different methodologies in recent years. The free development environment R was used to integrate open-source geographic information system (GIS) software, such as SAGA (System for Automated Geoscientific Analyses), GRASS (Geographic Resources Analysis Support System), or TauDEM (Terrain Analysis Using Digital Elevation Models). The implemented geographic-object-based image analysis (GEOBIA) consisted of (1) derivation of land surface parameters, such as slope, surface roughness, curvature, or flow direction, (2) finding optimal scale parameter by the use of an objective function, (3) multi-scale segmentation, (4) classification of landslide parts (main scarp, body, flanks) by k-mean thresholding, (5) assessment of the classification performance using a pre-existing landslide inventory, and (6) post-processing analysis for the further use in landslide inventories. The results of the developed open-source approach demonstrated good success rates to objectively detect landslides in high-resolution topography data by GEOBIA.

Performance simulation of a compact PET insert for simultaneous PET/MR breast imaging

NASA Astrophysics Data System (ADS)

Liang, Yicheng; Peng, Hao

2014-07-01

We studied performance metrics of a small PET ring designed to be integrated with a breast MRI coil. Its performance was characterized using a Monte Carlo simulation of a system with the best possible design features we believe are technically available, with respect to system geometry, spatial resolution, shielding, and lesion detectability. The results indicate that the proposed system is able to achieve about 6.2% photon detection sensitivity at the center of field-of-view (FOV) (crystal design: 2.2×2.2×20 mm3, height: 3.4 cm). The peak noise equivalent count rate (NECR) is found to be 7886 cps with a time resolution of 250 ps (time window: 500 ps). With the presence of lead shielding, the NECR increases by a factor of 1.7 for high activity concentrations within the breast (>0.9 μCi/mL), while no noticeable benefit is observed in the range of activities currently being used in the clinical setting. In addition, the system is able to achieve spatial resolution of 1.6 mm (2.2×2.2×20 mm3 crystal) and 0.77 mm (1×1×20 mm3 crystal) at the center of FOV, respectively. The incorporation of 10 mm DOI resolution can help mitigate parallax error towards the edge of FOV. For both 2.2 mm and 1 mm crystal designs, the spatial resolution is around 3.2-3.5 mm at 5 cm away from the center. Finally, time-of-flight (TOF) helps in improving image quality, reduces the required number of iteration numbers and the scan time. The TOF effect was studied with 3 different time resolution settings (1 ns, 500 ps and 250 ps). With a TOF of 500 ps time resolution, we expect 3 mm diameter spheres where 5:1 activity concentration ratio will be detectable within 5 min achieving contrast to noise ratio (CNR) above 4.

High-speed cell recognition algorithm for ultrafast flow cytometer imaging system.

PubMed

Zhao, Wanyue; Wang, Chao; Chen, Hongwei; Chen, Minghua; Yang, Sigang

2018-04-01

An optical time-stretch flow imaging system enables high-throughput examination of cells/particles with unprecedented high speed and resolution. A significant amount of raw image data is produced. A high-speed cell recognition algorithm is, therefore, highly demanded to analyze large amounts of data efficiently. A high-speed cell recognition algorithm consisting of two-stage cascaded detection and Gaussian mixture model (GMM) classification is proposed. The first stage of detection extracts cell regions. The second stage integrates distance transform and the watershed algorithm to separate clustered cells. Finally, the cells detected are classified by GMM. We compared the performance of our algorithm with support vector machine. Results show that our algorithm increases the running speed by over 150% without sacrificing the recognition accuracy. This algorithm provides a promising solution for high-throughput and automated cell imaging and classification in the ultrafast flow cytometer imaging platform. (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE).

High-speed cell recognition algorithm for ultrafast flow cytometer imaging system

NASA Astrophysics Data System (ADS)

Zhao, Wanyue; Wang, Chao; Chen, Hongwei; Chen, Minghua; Yang, Sigang

2018-04-01

An optical time-stretch flow imaging system enables high-throughput examination of cells/particles with unprecedented high speed and resolution. A significant amount of raw image data is produced. A high-speed cell recognition algorithm is, therefore, highly demanded to analyze large amounts of data efficiently. A high-speed cell recognition algorithm consisting of two-stage cascaded detection and Gaussian mixture model (GMM) classification is proposed. The first stage of detection extracts cell regions. The second stage integrates distance transform and the watershed algorithm to separate clustered cells. Finally, the cells detected are classified by GMM. We compared the performance of our algorithm with support vector machine. Results show that our algorithm increases the running speed by over 150% without sacrificing the recognition accuracy. This algorithm provides a promising solution for high-throughput and automated cell imaging and classification in the ultrafast flow cytometer imaging platform.

Analysis of the kinestatic charge detection system as a high detective quantum efficiency electronic portal imaging device.

PubMed

Samant, Sanjiv S; Gopal, Arun

2006-09-01

Megavoltage x-ray imaging suffers from reduced image quality due to low differential x-ray attenuation and large Compton scatter compared with kilovoltage imaging. Notwithstanding this, electronic portal imaging devices (EPIDs) are now widely used in portal verification in radiotherapy as they offer significant advantages over film, including immediate digital imaging and superior contrast range. However video-camera-based EPIDs (VEPIDs) are limited by problems of low light collection efficiency and significant light scatter, leading to reduced contrast and spatial resolution. Indirect and direct detection-based flat-panel EPIDs have been developed to overcome these limitations. While flat-panel image quality has been reported to exceed that achieved with portal film, these systems have detective quantum efficiency (DQE) limited by the thin detection medium and are sensitive to radiation damage to peripheral read-out electronics. An alternative technology for high-quality portal imaging is presented here: kinesatic charge detection (KCD). The KCD is a scanning tri-electrode ion-chamber containing high-pressure noble gas (xenon at 100 atm) used in conjunction with a strip-collimated photon beam. The chamber is scanned across the patient, and an external electric field is used to regulate the cation drift velocity. By matching the scanning velocity with that of the cation (i.e., ion) drift velocity, the cations remain static in the object frame of reference, allowing temporal integration of the signal. The KCD offers several advantages as a portal imaging system. It has a thick detector geometry with an active detection depth of 6.1 cm, compared to the sub-millimeter thickness of the phosphor layer in conventional phosphor screens, leading to an order of magnitude advantage in quantum efficiency (>0.3). The unique principle of and the use of the scanning strip-collimated x-ray beam provide further integration of charges in time, reduced scatter, and a significantly reduced imaging dose, enhancing the imaging signal-to-noise ratio (SNR) and leading to high DQE. While thick detectors usually suffer from reduced spatial resolution, the KCD provides good spatial resolution due to high gas pressure that limits the spread of scattered electrons, and a strip-collimated beam that significantly reduces the inclusion of scatter in the imaging signal. A 10 cm wide small-field-of-view (SFOV) prototype of the KCD is presented with a complete analysis of its imaging performance. Measurements of modulation transfer function (MTF), noise power spectrum (NPS), and DQE were in good agreement with Monte Carlo simulations. Imaging signal loss from recombination within the KCD chamber was measured at different gas pressures, ion drift velocities, and strip-collimation widths. Image quality for the prototype KCD was also observed with anthropomorphic phantom imaging in comparison with various commercial and research portal imaging systems, including VEPID, flat-panel imager, and conventional and high contrast film systems. KCD-based imaging provided very good contrast and good spatial resolution at very low imaging dose (0.1 cGy per image). For the prototype KCD, measurements yielded DQE(0)=0.19 and DQE(1 cy/mm)=0.004.

VizieR Online Data Catalog: KOIs companions from high-resolution imaging (Hirsch+, 2017)

NASA Astrophysics Data System (ADS)

Hirsch, L. A.; Ciardi, D. R.; Howard, A. W.; Everett, M. E.; Furlan, E.; Saylors, M.; Horch, E. P.; Howell, S. B.; Teske, J.; Marcy, G. W.

2017-07-01

We report on 176 close (<2'') stellar companions detected with high-resolution imaging near 170 hosts of Kepler Objects of Interest (KOIs). Our sample consists of 170 stellar hosts of Kepler Objects of Interest (KOIs) observed with various high-resolution imaging campaigns. This sample was drawn from the overall sample of KOI stars observed with high-resolution imaging, described in the imaging compilation paper by Furlan et al. 2017 (Cat. J/AJ/153/71). We choose targets for this study by requiring that at least one companion was detected within 2'', and that the companion was detected in two or more filters, providing color information. We choose the 2'' separation limit to include all companions falling on the same Kepler pixel as the primary KOI host star. Furlan et al. 2017 (Cat. J/AJ/153/71) details the observations and measured differential magnitudes (Δm=m2-m1) for stars with high-resolution imaging, including our target systems. Each companion within 2'' must have at least two measured Δm values from the full set of filters used for follow-up observations, in order to be included in our sample. These filters include J-band, H-band, and K-band from adaptive optics imaging from the Keck/NIRC2, Palomar/PHARO, Lick/IRCAL, and MMT/Aries instruments; 562, 692 and 880nm filters from the Differential Speckle Survey Instrument (DSSI) at the Gemini North and WIYN telescopes; i and z bands from the AstraLux lucky imaging campaign at the Calar Alto 2.2m telescope; and LP600 and i bands from Palomar/RoboAO. We also include seeing-limited observations in the U-, B-, and V-bands from the UBV survey (Everett et al.) and "secure" detections (noise probability <10%) in the J-band from the UKIRT Kepler field survey. (3 data files).

Timely detection and monitoring of oil leakage by satellite optical data.

NASA Astrophysics Data System (ADS)

Grimaldi, C. S. L.; Coviello, I.; Lacava, T.; Pergola, N.; Tramutoli, V.

2009-04-01

Sea oil pollution can derive from different sources. Accidental release of oil into the oceans caused by "human errors" (tankers collisions and/or shipwrecks) or natural hazards (hurricanes, landslides, earthquakes) have remarkable ecological impact on maritime and coastal environments. Katrina Hurricane, for example, hitting oil and gas infrastructures off USA coasts caused the destruction of more than 100 platforms and the release into the sea of more than 10,000 gallons of crude oil. In order to reduce the environmental impact of such kind of technological hazards, timely detection and continuously updated information are fundamental. Satellite remote sensing can give a significant contribution in such a direction. Nowadays, SAR (Synthetic Aperture Radar) technology has been recognized as the most efficient for oil spill detection and mapping, thanks to the high spatial resolution and all-time/weather capability of the present operational sensors. Anyway, due to their current revisiting cycles, SAR systems cannot be profitably used for a rapid detection and for a continuous and near real-time monitoring of these phenomena. Until COSMO-Skymed SAR constellation, that will be able to improve SAR observational frequency, will not be fully operational, passive optical sensors on board meteorological satellites, thanks to their high temporal resolution, may represent a suitable alternative for early detection and continuous monitoring of oil spills, provided that adequate and reliable data analysis techniques exist. Recently, an innovative technique for oil spill detection and monitoring, based on the general Robust Satellite Techniques (RST) approach, has been proposed. It exploits the multi-temporal analysis of optical data acquired by both AVHRR (Advanced Very High Resolution Radiometer) and MODIS (Moderate Resolution Imaging Spectroradiometer) sensors in order to detect, automatically and timely, the presence of oil spill over the sea surface, trying to minimize the "false-detections" possibly caused by spurious effects (e.g. clouds). In this paper, preliminary results obtained applying the proposed methodology to different test-cases are shown and discussed.

The value of Doppler LiDAR systems to monitor turbulence intensity during storm events in order to enhance aviation safety in Iceland

NASA Astrophysics Data System (ADS)

Yang, Shu; Nína Petersen, Guðrún; Finger, David C.

2017-04-01

Turbulence and wind shear are a major natural hazards for aviation safety in Iceland. The temporal and spatial scale of atmospheric turbulence is very dynamic, requiring an adequate method to detect and monitor turbulence with high resolution. The Doppler Light Detection and Ranging (LiDAR) system can provide continuous information about the wind field using the Doppler effect form emitted light signals. In this study, we use a Leosphere Windcube 200s LiDAR systems stationed near Reykjavik city Airport and at Keflavik International Airport, Iceland, to evaluate turbulence intensity by estimating eddy dissipation rate (EDR). For this purpose, we retrieved radial wind velocity observations from Velocity Azimuth Display (VAD) scans (360°scans at 15° and 75° elevation angle) to compute EDR. The method was used to monitor and characterize storm events in fall 2016 and the following winter. The preliminary result reveal that the LiDAR observations can detect and quantify atmospheric turbulence with high spatial and temporal resolution. This finding is an important step towards enhanced aviation safety in subpolar climate characterized by sever wind turbulence.

EKOSAT/DIAMANT - The Earth Observation Programme at OHB- System

NASA Astrophysics Data System (ADS)

Penne, B.; Tobehn, C.; Kassebom, M.; Luebberstedt

This paper covers the EKOSAT / DIAMANT programme heading for superspectral geo-information products. The EKOSAT / DIAMANT programme is based on a commercial strategy just before the realization of the first step - the EKOSAT launch in 2004. Further, we give an overview on OHB-System earth observation prime activities especially for infrared and radar. The EKOSAT/ DIAMANT is based on the MSRS sensor featuring 12 user dedicated spectral bands in the VIS/NIR with 5m spatial resolution and 26 km swath at an orbit of 670 km. The operational demonstrator mission EKOSAT is a Korean-Israelean-German-Russian initiative that aims in utilizing the existing proto-flight model of the KOMPSAT-1 spacecraft for the MSRS sensor, which development is finished. The EKOSAT pointing capability will allow a revisit time of 3 days. DIAMANT stands for the future full operational system based on dedicated small satellites. The basic constellation relying on 2-3 satellites with about one day revisit is extendend on market demand. EKOSAT/ DIAMANT is designed to fill the gap between modern high spatial resolution multispectral (MS) systems and hyperspectral systems with moderate spatial resolution. On European level, there is currently no remote sensing system operational with comparable features and capabilities concerning applications especially in the field of environmental issues, vegetation, agriculture and water bodies. The Space Segment has been designed to satisfy the user requirements based on a balance between commercial aspects and scientific approaches. For example eight spectral bands have been identified to cover almost the entire product range for the current market. Additional four bands have been implemented to be prepared for future applications as for example the improved red edge detection, which give better results regarding environmental conditions. The spacecraft design and its subsystems are still reasonable small in order to keep the mass below 200 kg. This is an important cost saving approach that surely offers higher viability of the system. The Intelligent Infrared Sensor System - FOCUS - aims at the reliable autonomous on-board detection of High Temperature Events (HTE) on Earth surface. The key to this task is the simultaneous co-registration of a combination of infrared (IR) and visible (VIS) channels. Furthermore there are ecology-oriented objectives mainly related to the sophisticated data fusion of spectrometric &imaging remote inspection and parameter extraction of selected HTEs, and to the assessment of ecological consequences of HTEs, such as aerosol and gas emission. The FOCUS Multi Sensor consists of two sensor systems: The Fore Field Sensor (FFS) will perform the wide-angle hot spot detection and mapping. For the on-board detected and selected hot spots, the Main Sensor (MS) will be targeted with a tiltable mirror and deliver detailed spatial high resolution observation. The MS is composed of an imaging system and a Fourier Spectrometer. The SAR-Lupe satellite system - under development by OHB-System - will generate high resolution SAR- (Synthetic Aperture Radar) images for military reconnaissance purposes. SAR-Lupe relies on a constellation of small satellites in low earth orbit, 1 control and 1 user ground segment.

Basilar artery atherosclerotic plaques in paramedian and lacunar pontine infarctions: a high-resolution MRI study.

PubMed

Klein, Isabelle F; Lavallée, Philippa C; Mazighi, Mikael; Schouman-Claeys, Elisabeth; Labreuche, Julien; Amarenco, Pierre

2010-07-01

Pontine infarction is most often related to basilar artery atherosclerosis when the lesion abuts on the basal surface (paramedian pontine infarction), whereas small medial pontine lesion is usually attributed to small vessel lipohyalinosis. A previous study has found that high-resolution MRI can detect basilar atherosclerotic plaques in up to 70% of patient with paramedian pontine infarction, even in patients with normal angiograms, but none has evaluated the presence of basilar artery plaque by high-resolution MRI in patients with small medial pontine lesion in the medial part of the pons. Consecutive patients with pontine infarction underwent basilar angiography using time-of-flight and contrast-enhanced 3-dimensional MR angiography to assess the presence of basilar artery stenosis and high-resolution MRI to assess the presence of atherosclerotic plaque. Basilar artery angiogram was scored as "normal," "irregular," or "stenosed" >or=30%" and basilar artery by high-resolution MRI was scored as "normal" or "presence of plaque." Medial pontine infarcts were divided into paramedian pontine infarction and small medial pontine lesion groups. Forty-one patients with pontine infarction were included, 26 with paramedian pontine infarction and 15 with small medial pontine lesion. High-resolution MRI detected basilar artery atherosclerosis in 42% of patients with a pontine infarction and normal basilar angiograms. Among patients with paramedian pontine infarction, 65% had normal basilar angiograms but 77% had basilar artery atherosclerosis detected on high-resolution MRI. Among patients with small medial pontine lesion, 46% had normal basilar angiograms but 73% had basilar artery plaques detected on by high-resolution MRI. This study suggests that medial pontine lacunes may be due to a penetrating artery disease secondary to basilar artery atherosclerosis. High-resolution MRI could help precise stroke subtyping.

High frequency ultrasound imaging using Fabry-Perot optical etalon

NASA Astrophysics Data System (ADS)

Ashkenazi, S.; Witte, R.; O'Donnell, M.

2005-04-01

Optical detection of ultrasound provides a unique and appealing way of forming detector arrays (1D or 2D) using either raster beam scanning or simultaneous array detection exploiting wide area illumination. Etalon based optical techniques are of particular interest, due to their relatively high sensitivity resulting from multiple optical reflections within the resonance structure. Detector arrays formed by etalon based techniques are characterized by high element density and small element active area, which enables high resolution imaging at high ultrasonic frequencies (typically 10-50 MHz). In this paper we present an application of an optical etalon structure for very high frequency ultrasound detection (exceeding 100 MHz). A thin polymer Fabry-Perot etalon (10 μm thickness) has been fabricated using spin coating of polymer photoresist on a glass substrate and gold evaporation forming partially reflecting mirrors on both faces of the polymer layer. The optical resonator formed by the etalon structure has a measured Q-factor of 300. The characteristic broadband response of the optical signal was demonstrated by insonifying the etalon using two different ultrasound transducers and recording the resulting intensity modulation of optical reflection from the etalon. A focused 10 MHz transducer was used for the low MHz frequency region, and a 50 MHz focused transducer was used for the high frequency region. The optical reflection signal was compared to the pulse/echo signal detected by the same ultrasound transducer. The measured signal to noise ratio of the optically detected signal is comparable to that of the pulse/echo signal in both low and high frequency ranges. The etalon detector was integrated in a photoacoustic imaging system. High resolution images of phantom targets and biological tissue (nerve cord) were obtained. The additional information of optical absorption obtained by photoacoustic imaging, along with the high resolution detection of the etalon, offer unique advantages for intravascular and neurological imaging devices.

Electro-optical design of a long slit streak tube

NASA Astrophysics Data System (ADS)

Tian, Liping; Tian, Jinshou; Wen, Wenlong; Chen, Ping; Wang, Xing; Hui, Dandan; Wang, Junfeng

2017-11-01

A small size and long slit streak tube with high spatial resolution was designed and optimized. Curved photocathode and screen were adopted to increase the photocathode working area and spatial resolution. High physical temporal resolution obtained by using a slit accelerating electrode. Deflection sensitivity of the streak tube was improved by adopting two-folded deflection plates. The simulations indicate that the photocathode effective working area can reach 30mm × 5mm. The static spatial resolution is higher than 40lp/mm and 12lp/mm along scanning and slit directions respectively while the physical temporal resolution is higher than 60ps. The magnification is 0.75 and 0.77 in scanning and slit directions. And also, the deflection sensitivity is as high as 37mm/kV. The external dimension of the streak tube are only ∅74mm×231mm. Thus, it can be applied to laser imaging radar system for large field of view and high range precision detection.

Two micron pore size MCP-based image intensifiers

NASA Astrophysics Data System (ADS)

Glesener, John; Estrera, Joseph

2010-02-01

Image intensifiers (I2) have many advantages as detectors. They offer single photon sensitivity in an imaging format, they're light in weight and analog I2 systems can operate for hours on a single AA battery. Their light output is such as to exploit the peak in color sensitivity of the human eye. Until recent developments in CMOS sensors, they also were one of the highest resolution sensors available. The closest all solid state solution, the Texas Instruments Impactron chip, comes in a 1 megapixel format. Depending on the level of integration, an Impactron based system can consume 20 to 40 watts in a system configuration. In further investing in I2 technology, L-3 EOS determined that increasing I2 resolution merited a high priority. Increased I2 resolution offers the system user two desirable options: 1) increased detection and identification ranges while maintaining field-of-view (FOV) or 2) increasing FOV while maintaining the original system resolution. One of the areas where an investment in resolution is being made is in the microchannel plate (MCP). Incorporation of a 2 micron MCP into an image tube has the potential of increasing the system resolution of currently fielded systems. Both inverting and non-inverting configurations are being evaluated. Inverting tubes are being characterized in night vision goggle (NVG) and sights. The non-inverting 2 micron tube is being characterized for high resolution I2CMOS camera applications. Preliminary measurements show an increase in the MTF over a standard 5 micron pore size, 6 micron pitch plate. Current results will be presented.

Imaging Analysis of the Hard X-Ray Telescope ProtoEXIST2 and New Techniques for High-Resolution Coded-Aperture Telescopes

NASA Technical Reports Server (NTRS)

Hong, Jaesub; Allen, Branden; Grindlay, Jonathan; Barthelmy, Scott D.

2016-01-01

Wide-field (greater than or approximately equal to 100 degrees squared) hard X-ray coded-aperture telescopes with high angular resolution (greater than or approximately equal to 2 minutes) will enable a wide range of time domain astrophysics. For instance, transient sources such as gamma-ray bursts can be precisely localized without the assistance of secondary focusing X-ray telescopes to enable rapid followup studies. On the other hand, high angular resolution in coded-aperture imaging introduces a new challenge in handling the systematic uncertainty: the average photon count per pixel is often too small to establish a proper background pattern or model the systematic uncertainty in a timescale where the model remains invariant. We introduce two new techniques to improve detection sensitivity, which are designed for, but not limited to, a high-resolution coded-aperture system: a self-background modeling scheme which utilizes continuous scan or dithering operations, and a Poisson-statistics based probabilistic approach to evaluate the significance of source detection without subtraction in handling the background. We illustrate these new imaging analysis techniques in high resolution coded-aperture telescope using the data acquired by the wide-field hard X-ray telescope ProtoEXIST2 during a high-altitude balloon flight in fall 2012. We review the imaging sensitivity of ProtoEXIST2 during the flight, and demonstrate the performance of the new techniques using our balloon flight data in comparison with a simulated ideal Poisson background.

Whole mouse cryo-imaging

NASA Astrophysics Data System (ADS)

Wilson, David; Roy, Debashish; Steyer, Grant; Gargesha, Madhusudhana; Stone, Meredith; McKinley, Eliot

2008-03-01

The Case cryo-imaging system is a section and image system which allows one to acquire micron-scale, information rich, whole mouse color bright field and molecular fluorescence images of an entire mouse. Cryo-imaging is used in a variety of applications, including mouse and embryo anatomical phenotyping, drug delivery, imaging agents, metastastic cancer, stem cells, and very high resolution vascular imaging, among many. Cryo-imaging fills the gap between whole animal in vivo imaging and histology, allowing one to image a mouse along the continuum from the mouse -> organ -> tissue structure -> cell -> sub-cellular domains. In this overview, we describe the technology and a variety of exciting applications. Enhancements to the system now enable tiled acquisition of high resolution images to cover an entire mouse. High resolution fluorescence imaging, aided by a novel subtraction processing algorithm to remove sub-surface fluorescence, makes it possible to detect fluorescently-labeled single cells. Multi-modality experiments in Magnetic Resonance Imaging and Cryo-imaging of a whole mouse demonstrate superior resolution of cryo-images and efficiency of registration techniques. The 3D results demonstrate the novel true-color volume visualization tools we have developed and the inherent advantage of cryo-imaging in providing unlimited depth of field and spatial resolution. The recent results continue to demonstrate the value cryo-imaging provides in the field of small animal imaging research.

Noncontact photoacoustic imaging by using a modified optical-fiber Michelson interferometer

NASA Astrophysics Data System (ADS)

Lu, Jiao; Gao, Yingzhe; Ma, Zhenhe; Wang, Bo; Wang, Yi

2016-03-01

We demonstrate a noncontact photoacoustic imaging (PAI) system in which an optical interferometer is used for ultrasound detection. The system is based on a modified optical-fiber Michelson interferometer that measures the surface displacement caused by photoacoustic pressure. A synchronization method is utilized to keep its high sensitivity to reduce the influence of ambient vibrations. The system is experimentally verified by imaging of a phantom. The experimental results indicate that the proposed system can be used for noncontact PAI with high resolution and high bandwidth.

Ultra-high resolution of radiocesium distribution detection based on Cherenkov light imaging

NASA Astrophysics Data System (ADS)

Yamamoto, Seiichi; Ogata, Yoshimune; Kawachi, Naoki; Suzui, Nobuo; Yin, Yong-Gen; Fujimaki, Shu

2015-03-01

After the nuclear disaster in Fukushima, radiocesium contamination became a serious scientific concern and research of its effects on plants increased. In such plant studies, high resolution images of radiocesium are required without contacting the subjects. Cherenkov light imaging of beta radionuclides has inherently high resolution and is promising for plant research. Since 137Cs and 134Cs emit beta particles, Cherenkov light imaging will be useful for the imaging of radiocesium distribution. Consequently, we developed and tested a Cherenkov light imaging system. We used a high sensitivity cooled charge coupled device (CCD) camera (Hamamatsu Photonics, ORCA2-ER) for imaging Cherenkov light from 137Cs. A bright lens (Xenon, F-number: 0.95, lens diameter: 25 mm) was mounted on the camera and placed in a black box. With a 100-μm 137Cs point source, we obtained 220-μm spatial resolution in the Cherenkov light image. With a 1-mm diameter, 320-kBq 137Cs point source, the source was distinguished within 2-s. We successfully obtained Cherenkov light images of a plant whose root was dipped in a 137Cs solution, radiocesium-containing samples as well as line and character phantom images with our imaging system. Cherenkov light imaging is promising for the high resolution imaging of radiocesium distribution without contacting the subject.

Auditory Temporal Resolution in Individuals with Diabetes Mellitus Type 2.

PubMed

Mishra, Rajkishor; Sanju, Himanshu Kumar; Kumar, Prawin

2016-10-01

Introduction  "Diabetes mellitus is a group of metabolic disorders characterized by elevated blood sugar and abnormalities in insulin secretion and action" (American Diabetes Association). Previous literature has reported connection between diabetes mellitus and hearing impairment. There is a dearth of literature on auditory temporal resolution ability in individuals with diabetes mellitus type 2. Objective  The main objective of the present study was to assess auditory temporal resolution ability through GDT (Gap Detection Threshold) in individuals with diabetes mellitus type 2 with high frequency hearing loss. Methods  Fifteen subjects with diabetes mellitus type 2 with high frequency hearing loss in the age range of 30 to 40 years participated in the study as the experimental group. Fifteen age-matched non-diabetic individuals with normal hearing served as the control group. We administered the Gap Detection Threshold (GDT) test to all participants to assess their temporal resolution ability. Result  We used the independent t -test to compare between groups. Results showed that the diabetic group (experimental) performed significantly poorer compared with the non-diabetic group (control). Conclusion  It is possible to conclude that widening of auditory filters and changes in the central auditory nervous system contributed to poorer performance for temporal resolution task (Gap Detection Threshold) in individuals with diabetes mellitus type 2. Findings of the present study revealed the deteriorating effect of diabetes mellitus type 2 at the central auditory processing level.

A compact high resolution ion mobility spectrometer for fast trace gas analysis.

PubMed

Kirk, Ansgar T; Allers, Maria; Cochems, Philipp; Langejuergen, Jens; Zimmermann, Stefan

2013-09-21

Drift tube ion mobility spectrometers (IMS) are widely used for fast trace gas detection in air, but portable compact systems are typically very limited in their resolving power. Decreasing the initial ion packet width improves the resolution, but is generally associated with a reduced signal-to-noise-ratio (SNR) due to the lower number of ions injected into the drift region. In this paper, we present a refined theory of IMS operation which employs a combined approach for the analysis of the ion drift and the subsequent amplification to predict both the resolution and the SNR of the measured ion current peak. This theoretical analysis shows that the SNR is not a function of the initial ion packet width, meaning that compact drift tube IMS with both very high resolution and extremely low limits of detection can be designed. Based on these implications, an optimized combination of a compact drift tube with a length of just 10 cm and a transimpedance amplifier has been constructed with a resolution of 183 measured for the positive reactant ion peak (RIP(+)), which is sufficient to e.g. separate the RIP(+) from the protonated acetone monomer, even though their drift times only differ by a factor of 1.007. Furthermore, the limits of detection (LODs) for acetone are 180 pptv within 1 s of averaging time and 580 pptv within only 100 ms.

Framework for Detection and Localization of Extreme Climate Event with Pixel Recursive Super Resolution

NASA Astrophysics Data System (ADS)

Kim, S. K.; Lee, J.; Zhang, C.; Ames, S.; Williams, D. N.

2017-12-01

Deep learning techniques have been successfully applied to solve many problems in climate and geoscience using massive-scaled observed and modeled data. For extreme climate event detections, several models based on deep neural networks have been recently proposed and attend superior performance that overshadows all previous handcrafted expert based method. The issue arising, though, is that accurate localization of events requires high quality of climate data. In this work, we propose framework capable of detecting and localizing extreme climate events in very coarse climate data. Our framework is based on two models using deep neural networks, (1) Convolutional Neural Networks (CNNs) to detect and localize extreme climate events, and (2) Pixel recursive recursive super resolution model to reconstruct high resolution climate data from low resolution climate data. Based on our preliminary work, we have presented two CNNs in our framework for different purposes, detection and localization. Our results using CNNs for extreme climate events detection shows that simple neural nets can capture the pattern of extreme climate events with high accuracy from very coarse reanalysis data. However, localization accuracy is relatively low due to the coarse resolution. To resolve this issue, the pixel recursive super resolution model reconstructs the resolution of input of localization CNNs. We present a best networks using pixel recursive super resolution model that synthesizes details of tropical cyclone in ground truth data while enhancing their resolution. Therefore, this approach not only dramat- ically reduces the human effort, but also suggests possibility to reduce computing cost required for downscaling process to increase resolution of data.

Combining endoscopic ultrasound with Time-Of-Flight PET: The EndoTOFPET-US Project

NASA Astrophysics Data System (ADS)

Frisch, Benjamin

2013-12-01

The EndoTOFPET-US collaboration develops a multimodal imaging technique for endoscopic exams of the pancreas or the prostate. It combines the benefits of high resolution metabolic imaging with Time-Of-Flight Positron Emission Tomography (TOF PET) and anatomical imaging with ultrasound (US). EndoTOFPET-US consists of a PET head extension for a commercial US endoscope and a PET plate outside the body in coincidence with the head. The high level of miniaturization and integration creates challenges in fields such as scintillating crystals, ultra-fast photo-detection, highly integrated electronics, system integration and image reconstruction. Amongst the developments, fast scintillators as well as fast and compact digital SiPMs with single SPAD readout are used to obtain the best coincidence time resolution (CTR). Highly integrated ASICs and DAQ electronics contribute to the timing performances of EndoTOFPET. In view of the targeted resolution of around 1 mm in the reconstructed image, we present a prototype detector system with a CTR better than 240 ps FWHM. We discuss the challenges in simulating such a system and introduce reconstruction algorithms based on graphics processing units (GPU).

A high frequency electromagnetic impedance imaging system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tseng, Hung-Wen; Lee, Ki Ha; Becker, Alex

2003-01-15

Non-invasive, high resolution geophysical mapping of the shallow subsurface is necessary for delineation of buried hazardous wastes, detecting unexploded ordinance, verifying and monitoring of containment or moisture contents, and other environmental applications. Electromagnetic (EM) techniques can be used for this purpose since electrical conductivity and dielectric permittivity are representative of the subsurface media. Measurements in the EM frequency band between 1 and 100 MHz are very important for such applications, because the induction number of many targets is small and the ability to determine the subsurface distribution of both electrical properties is required. Earlier workers were successful in developing systemsmore » for detecting anomalous areas, but quantitative interpretation of the data was difficult. Accurate measurements are necessary, but difficult to achieve for high-resolution imaging of the subsurface. We are developing a broadband non-invasive method for accurately mapping the electrical conductivity and dielectric permittivity of the shallow subsurface using an EM impedance approach similar to the MT exploration technique. Electric and magnetic sensors were tested to ensure that stray EM scattering is minimized and the quality of the data collected with the high-frequency impedance (HFI) system is good enough to allow high-resolution, multi-dimensional imaging of hidden targets. Additional efforts are being made to modify and further develop existing sensors and transmitters to improve the imaging capability and data acquisition efficiency.« less

Improving catchment scale water quality modelling with continuous high resolution monitoring of metals in runoff

NASA Astrophysics Data System (ADS)

Saari, Markus; Rossi, Pekka; Blomberg von der Geest, Kalle; Mäkinen, Ari; Postila, Heini; Marttila, Hannu

2017-04-01

High metal concentrations in natural waters is one of the key environmental and health problems globally. Continuous in-situ analysis of metals from runoff water is technically challenging but essential for the better understanding of processes which lead to pollutant transport. Currently, typical analytical methods for monitoring elements in liquids are off-line laboratory methods such as ICP-OES (Inductively Coupled Plasma Optical Emission Spectroscopy) and ICP-MS (ICP combined with a mass spectrometer). Disadvantage of the both techniques is time consuming sample collection, preparation, and off-line analysis at laboratory conditions. Thus use of these techniques lack possibility for real-time monitoring of element transport. We combined a novel high resolution on-line metal concentration monitoring with catchment scale physical hydrological modelling in Mustijoki river in Southern Finland in order to study dynamics of processes and form a predictive warning system for leaching of metals. A novel on-line measurement technique based on micro plasma emission spectroscopy (MPES) is tested for on-line detection of selected elements (e.g. Na, Mg, Al, K, Ca, Fe, Ni, Cu, Cd and Pb) in runoff waters. The preliminary results indicate that MPES can sufficiently detect and monitor metal concentrations from river water. Water and Soil Assessment Tool (SWAT) catchment scale model was further calibrated with high resolution metal concentration data. We show that by combining high resolution monitoring and catchment scale physical based modelling, further process studies and creation of early warning systems, for example to optimization of drinking water uptake from rivers, can be achieved.

RADIAL VELOCITY VARIABILITY OF FIELD BROWN DWARFS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prato, L.; Mace, G. N.; Rice, E. L.

2015-07-20

We present paper six of the NIRSPEC Brown Dwarf Spectroscopic Survey, an analysis of multi-epoch, high-resolution (R ∼ 20,000) spectra of 25 field dwarf systems (3 late-type M dwarfs, 16 L dwarfs, and 6 T dwarfs) taken with the NIRSPEC infrared spectrograph at the W. M. Keck Observatory. With a radial velocity (RV) precision of ∼2 km s{sup −1}, we are sensitive to brown dwarf companions in orbits with periods of a few years or less given a mass ratio of 0.5 or greater. We do not detect any spectroscopic binary brown dwarfs in the sample. Given our target properties,more » and the frequency and cadence of observations, we use a Monte Carlo simulation to determine the detection probability of our sample. Even with a null detection result, our 1σ upper limit for very low mass binary frequency is 18%. Our targets included seven known, wide brown dwarf binary systems. No significant RV variability was measured in our multi-epoch observations of these systems, even for those pairs for which our data spanned a significant fraction of the orbital period. Specialized techniques are required to reach the high precisions sensitive to motion in orbits of very low-mass systems. For eight objects, including six T dwarfs, we present the first published high-resolution spectra, many with high signal to noise, that will provide valuable comparison data for models of brown dwarf atmospheres.« less

The recognition of extraterrestrial artificial signals

NASA Technical Reports Server (NTRS)

Seeger, C. L.

1980-01-01

Considerations in the design of receivers for the detection and recognition of artificial microwave signals of extraterrestrial origin are discussed. Following a review of the objectives of SETI and the probable reception and detection characteristics of extraterrestrial signals, means for the improvement of the sensitivity, signal-to-noise ratios and on-line data processing capabilities of SETI receivers are indicated. The characteristics of the signals likely to be present at the output of an ultra-low-noise microwave receiver are then examined, including the system background noise, terrestrial radiations, astrophysical radiations, accidental artificial radiations of terrestrial origin, and intentional radiations produced by humans and by extraterrestrial intelligence. The classes of extraterrestrial signals likely to be detected, beacons and leakage signals, are considered, and options in the specification of gating and thresholding for a high-spectral resolution, high-time-resolution signal discriminator are indicated. Possible tests for the nonhuman origin of a received signal are also pointed out.

The ALMA correlator

NASA Astrophysics Data System (ADS)

Escoffier, R. P.; Comoretto, G.; Webber, J. C.; Baudry, A.; Broadwell, C. M.; Greenberg, J. H.; Treacy, R. R.; Cais, P.; Quertier, B.; Camino, P.; Bos, A.; Gunst, A. W.

2007-02-01

Aims: The Atacama Large Millimeter Array (ALMA) is an international astronomy facility to be used for detecting and imaging all types of astronomical sources at millimeter and submillimeter wavelengths at a 5000-m elevation site in the Atacama Desert of Chile. Our main aims are: describe the correlator sub-system which is that part of the ALMA system that combines the signal from up to 64 remote individual radio antennas and forms them into a single instrument; emphasize the high spectral resolution and the configuration flexibility available with the ALMA correlator. Methods: The main digital signal processing features and a block diagram of the correlator being constructed for the ALMA radio astronomy observatory are presented. Tables of observing modes and spectral resolutions offered by the correlator system are given together with some examples of multi-resolution spectral modes. Results: The correlator is delivered by quadrants and the first quadrant is being tested while most of the other printed circuit cards required by the system have been produced. In its final version the ALMA correlator will process the outputs of up to 64 antennas using an instantaneous bandwidth of 8 GHz in each of two polarizations per antenna. In the frequency division mode, unrivalled spectral flexibility together with very high resolution (3.8 kHz) and up to 8192 spectral points are achieved. In the time division mode high time resolution is available with minimum data dump rates of 16 ms for all cross-products.

Scaled multisensor inspection of extended surfaces for industrial quality control

NASA Astrophysics Data System (ADS)

Kayser, Daniel; Bothe, Thorsten; Osten, Wolfgang

2002-06-01

Reliable real-time surface inspection of extended surfaces with high resolution is needed in several industrial applications. With respect to an efficient application to extended technical components such as aircraft or automotive parts, the inspection system has to perform a robust measurement with a ratio of less then 10-6 between depth resolution and lateral extension. This ratio is at least one order beyond the solutions that are offered by existing technologies. The concept of scaled topometry consists of arranging different optical measurement techniques with overlapping ranges of resolution systematically in order to receive characteristic surface information with the required accuracy. In such a surface inspection system, an active algorithm combines measurements on several scales of resolution and distinguishes between local fault indicating structures with different extensions and global geometric properties. The first part of this active algorithm finds indications of critical surface areas in the data of every measurement and separates them into different categories. The second part analyses the detected structures in the data with respect to their resolution and decides whether a further local measurement with a higher resolution has to be performed. The third part positions the sensors and starts the refined measurements. The fourth part finally integrates the measured local data set into the overall data mesh. We have constructed a laboratory setup capable of measuring surfaces with extensions up to 1500mm x 1000mm x 500mm (in x-, y- and z-direction respectively). Using this measurement system we will be able to separate the fault indicating structures on the surface from the global shape and to classify the detected structures according to their extensions and characteristic shapes simultaneously. The level of fault detection probability will be applicable by input parameter control.

Development and characterization of high-resolution neutron pixel detectors based on Timepix read-out chips

NASA Astrophysics Data System (ADS)

Krejci, F.; Zemlicka, J.; Jakubek, J.; Dudak, J.; Vavrik, D.; Köster, U.; Atkins, D.; Kaestner, A.; Soltes, J.; Viererbl, L.; Vacik, J.; Tomandl, I.

2016-12-01

Using a suitable isotope such as 6Li and 10B semiconductor hybrid pixel detectors can be successfully adapted for position sensitive detection of thermal and cold neutrons via conversion into energetic light ions. The adapted devices then typically provides spatial resolution at the level comparable to the pixel pitch (55 μm) and sensitive area of about few cm2. In this contribution, we describe further progress in neutron imaging performance based on the development of a large-area hybrid pixel detector providing practically continuous neutron sensitive area of 71 × 57 mm2. The measurements characterising the detector performance at the cold neutron imaging instrument ICON at PSI and high-flux imaging beam-line Neutrograph at ILL are presented. At both facilities, high-resolution high-contrast neutron radiography with the newly developed detector has been successfully applied for objects which imaging were previously difficult with hybrid pixel technology (such as various composite materials, objects of cultural heritage etc.). Further, a significant improvement in the spatial resolution of neutron radiography with hybrid semiconductor pixel detector based on the fast read-out Timepix-based detector is presented. The system is equipped with a thin planar 6LiF convertor operated effectively in the event-by-event mode enabling position sensitive detection with spatial resolution better than 10 μm.

Optical imaging modalities: From design to diagnosis of skin cancer

NASA Astrophysics Data System (ADS)

Korde, Vrushali Raj

This study investigates three high resolution optical imaging modalities to better detect and diagnose skin cancer. The ideal high resolution optical imaging system can visualize pre-malignant tissue growth non-invasively with resolution comparable to histology. I examined 3 modalities which approached this goal. The first method examined was high magnification microscopy of thin stained tissue sections, together with a statistical analysis of nuclear chromatin patterns termed Karyometry. This method has subcellular resolution, but it necessitates taking a biopsy at the desired tissue site and imaging the tissue ex-vivo. My part of this study was to develop an automated nuclear segmentation algorithm to segment cell nuclei in skin histology images for karyometric analysis. The results of this algorithm were compared to hand segmented cell nuclei in the same images, and it was concluded that the automated segmentations can be used for karyometric analysis. The second optical imaging modality I investigated was Optical Coherence Tomography (OCT). OCT is analogous to ultrasound, in which sound waves are delivered into the body and the echo time and reflected signal magnitude are measured. Due to the fast speed of light and detector temporal integration times, low coherence interferometry is needed to gate the backscattered light. OCT acquires cross sectional images, and has an axial resolution of 1-15 mum (depending on the source bandwidth) and a lateral resolution of 10-20 mum (depending on the sample arm optics). While it is not capable of achieving subcellular resolution, it is a non-invasive imaging modality. OCT was used in this study to evaluate skin along a continuum from normal to sun damaged to precancer. I developed algorithms to detect statistically significant differences between images of sun protected and sun damaged skin, as well as between undiseased and precancerous skin. An Optical Coherence Microscopy (OCM) endoscope was developed in the third portion of this study. OCM is a high resolution en-face imaging modality. It is a hybrid system that combines the principles of confocal microscopy with coherence gating to provide an increased imaging depth. It can also be described as an OCT system with a high NA objective. Similar to OCT, the axial resolution is determined by the source center wavelength and bandwidth. The NA of the sample arm optics determines the lateral resolution, usually on the order of 1-5 mum. My effort on this system was to develop a handheld endoscope. To my knowledge, an OCM endoscope has not been developed prior to this work. An image of skin was taken as a proof of concept. This rigid handheld OCM endoscope will be useful for applications ranging from minimally invasive surgical imaging to non-invasively assessing dysplasia and sun damage in skin.

Study of a high-resolution PET system using a Silicon detector probe

NASA Astrophysics Data System (ADS)

Brzeziński, K.; Oliver, J. F.; Gillam, J.; Rafecas, M.

2014-10-01

A high-resolution silicon detector probe, in coincidence with a conventional PET scanner, is expected to provide images of higher quality than those achievable using the scanner alone. Spatial resolution should improve due to the finer pixelization of the probe detector, while increased sensitivity in the probe vicinity is expected to decrease noise. A PET-probe prototype is being developed utilizing this principle. The system includes a probe consisting of ten layers of silicon detectors, each a 80 × 52 array of 1 × 1 × 1 mm3 pixels, to be operated in coincidence with a modern clinical PET scanner. Detailed simulation studies of this system have been performed to assess the effect of the additional probe information on the quality of the reconstructed images. A grid of point sources was simulated to study the contribution of the probe to the system resolution at different locations over the field of view (FOV). A resolution phantom was used to demonstrate the effect on image resolution for two probe positions. A homogeneous source distribution with hot and cold regions was used to demonstrate that the localized improvement in resolution does not come at the expense of the overall quality of the image. Since the improvement is constrained to an area close to the probe, breast imaging is proposed as a potential application for the novel geometry. In this sense, a simplified breast phantom, adjacent to heart and torso compartments, was simulated and the effect of the probe on lesion detectability, through measurements of the local contrast recovery coefficient-to-noise ratio (CNR), was observed. The list-mode ML-EM algorithm was used for image reconstruction in all cases. As expected, the point spread function of the PET-probe system was found to be non-isotropic and vary with position, offering improvement in specific regions. Increase in resolution, of factors of up to 2, was observed in the region close to the probe. Images of the resolution phantom showed visible improvement in resolution when including the probe in the simulations. The image quality study demonstrated that contrast and spill-over ratio in other areas of the FOV were not sacrificed for this enhancement. The CNR study performed on the breast phantom indicates increased lesion detectability provided by the probe.

Eye gazing direction inspection based on image processing technique

NASA Astrophysics Data System (ADS)

Hao, Qun; Song, Yong

2005-02-01

According to the research result in neural biology, human eyes can obtain high resolution only at the center of view of field. In the research of Virtual Reality helmet, we design to detect the gazing direction of human eyes in real time and feed it back to the control system to improve the resolution of the graph at the center of field of view. In the case of current display instruments, this method can both give attention to the view field of virtual scene and resolution, and improve the immersion of virtual system greatly. Therefore, detecting the gazing direction of human eyes rapidly and exactly is the basis of realizing the design scheme of this novel VR helmet. In this paper, the conventional method of gazing direction detection that based on Purklinje spot is introduced firstly. In order to overcome the disadvantage of the method based on Purklinje spot, this paper proposed a method based on image processing to realize the detection and determination of the gazing direction. The locations of pupils and shapes of eye sockets change with the gazing directions. With the aid of these changes, analyzing the images of eyes captured by the cameras, gazing direction of human eyes can be determined finally. In this paper, experiments have been done to validate the efficiency of this method by analyzing the images. The algorithm can carry out the detection of gazing direction base on normal eye image directly, and it eliminates the need of special hardware. Experiment results show that the method is easy to implement and have high precision.

A high-resolution and intelligent dead pixel detection scheme for an electrowetting display screen

NASA Astrophysics Data System (ADS)

Luo, ZhiJie; Luo, JianKun; Zhao, WenWen; Cao, Yang; Lin, WeiJie; Zhou, GuoFu

2018-02-01

Electrowetting display technology is realized by tuning the surface energy of a hydrophobic surface by applying a voltage based on electrowetting mechanism. With the rapid development of the electrowetting industry, how to analyze efficiently the quality of an electrowetting display screen has a very important significance. There are two kinds of dead pixels on the electrowetting display screen. One is that the oil of pixel cannot completely cover the display area. The other is that indium tin oxide semiconductor wire connecting pixel and foil was burned. In this paper, we propose a high-resolution and intelligent dead pixel detection scheme for an electrowetting display screen. First, we built an aperture ratio-capacitance model based on the electrical characteristics of electrowetting display. A field-programmable gate array is used as the integrated logic hub of the system for a highly reliable and efficient control of the circuit. Dead pixels can be detected and displayed on a PC-based 2D graphical interface in real time. The proposed dead pixel detection scheme reported in this work has promise in automating electrowetting display experiments.

Detection system for neutron β decay correlations in the UCNB and Nab experiments

DOE PAGES

Broussard, L. J.; Oak Ridge National Lab.; Zeck, B. A.; ...

2016-12-19

Here, we describe a detection system designed to precisely measure multiple correlations in neutron β decay. Furthermore, the system is based on thick, large area, highly segmented silicon detectors developed in collaboration with Micron Semiconductor, Ltd. The prototype system meets specifications of energy thresholds below 10 keV, energy resolution of ~3 keV FWHM, and rise time of ~50 ns with 19 of the 127 detector pixels instrumented. We have demonstrated the coincident detection of β particles and recoil protons from neutron β decay, using ultracold neutrons at the Los Alamos Neutron Science Center, . The fully instrumented detection system willmore » be implemented in the UCNB and Nab experiments, to determine the neutron β decay parameters B, a, and b.« less

Environmental applications of single collector high resolution ICP-MS.

PubMed

Krachler, Michael

2007-08-01

The number of environmental applications of single collector high resolution ICP-MS (HR-ICP-MS) has increased rapidly in recent years. There are many factors that contribute to make HR-ICP-MS a very powerful tool in environmental analysis. They include the extremely low detection limits achievable, tremendously high sensitivity, the ability to separate ICP-MS signals of the analyte from spectral interferences, enabling the reliable determination of many trace elements, and the reasonable precision of isotope ratio measurements. These assets are improved even further using high efficiency sample introduction systems. Therefore, external factors such as the stability of laboratory blanks are frequently the limiting factor in HR-ICP-MS analysis rather than the detection power. This review aims to highlight the most recent applications of HR-ICP-MS in this sector, focusing on matrices and applications where the superior capabilities of the instrumental technique are most useful and often ultimately required.

Modelling high-resolution ALMA observations of strongly lensed highly star-forming galaxies detected by Herschel

NASA Astrophysics Data System (ADS)

Dye, S.; Furlanetto, C.; Dunne, L.; Eales, S. A.; Negrello, M.; Nayyeri, H.; van der Werf, P. P.; Serjeant, S.; Farrah, D.; Michałowski, M. J.; Baes, M.; Marchetti, L.; Cooray, A.; Riechers, D. A.; Amvrosiadis, A.

2018-06-01

We have modelled ˜0.1 arcsec resolution Atacama Large Millimetre/submillimeter Array imaging of six strong gravitationally lensed galaxies detected by the Herschel Space Observatory. Our modelling recovers mass properties of the lensing galaxies and, by determining magnification factors, intrinsic properties of the lensed submillimetre sources. We find that the lensed galaxies all have high ratios of star formation rate to dust mass, consistent with or higher than the mean ratio for high-redshift submillimetre galaxies and low-redshift ultra-luminous infrared galaxies. Source reconstruction reveals that most galaxies exhibit disturbed morphologies. Both the cleaned image plane data and the directly observed interferometric visibilities have been modelled, enabling comparison of both approaches. In the majority of cases, the recovered lens models are consistent between methods, all six having mass density profiles that are close to isothermal. However, one system with poor signal to noise shows mildly significant differences.

Using High Spatial Resolution to Improve BOLD fMRI Detection at 3T

PubMed Central

Claise, Béatrice; Jean, Betty

2015-01-01

For different functional magnetic resonance imaging experiments using blood oxygenation level-dependent (BOLD) contrast, the acquisition of T 2*-weighted scans at a high spatial resolution may be advantageous in terms of time-course signal-to-noise ratio and of BOLD sensitivity when the regions are prone to susceptibility artifacts. In this study, we explore this solution by examining how spatial resolution influences activations elicited when appetizing food pictures are viewed. Twenty subjects were imaged at 3 T with two different voxel volumes, 3.4 μl and 27 μl. Despite the diminution of brain coverage, we found that high-resolution acquisition led to a better detection of activations. Though known to suffer to different degrees from susceptibility artifacts, the activations detected by high spatial resolution were notably consistent with those reported in published activation likelihood estimation meta-analyses, corresponding to taste-responsive regions. Furthermore, these regions were found activated bilaterally, in contrast with previous findings. Both the reduction of partial volume effect, which improves BOLD contrast, and the mitigation of susceptibility artifact, which boosts the signal to noise ratio in certain regions, explained the better detection noted with high resolution. The present study provides further evidences that high spatial resolution is a valuable solution for human BOLD fMRI, especially for studying food-related stimuli. PMID:26550990

One Decade of Induced Seismicity in Basel, Switzerland: A Consistent High-Resolution Catalog Obtained by Template Matching

NASA Astrophysics Data System (ADS)

Herrmann, M.; Kraft, T.; Tormann, T.; Scarabello, L.; Wiemer, S.

2017-12-01

Induced seismicity at the site of the Basel Enhanced Geothermal System (EGS) continuously decayed for six years after injection had been stopped in December 2006. Starting in May 2012, the Swiss Seismological Service was detecting a renewed increase of induced seismicity in the EGS reservoir to levels last seen in 2007 and reaching magnitudes up to ML2.0. Seismic monitoring at this EGS site is running for more than ten years now, but the details of the long-term behavior of its induced seismicity remained unexplored because a seismic event catalog that is consistent in detection sensitivity and magnitude estimation did not exist.We have created such a catalog by applying our matched filter detector to the 11-year-long seismic recordings of a borehole station at 2.7km depth. Based on 3'600 located earthquakes of the operator's borehole-network catalog, we selected about 2'500 reasonably dissimilar templates using waveform clustering. This large template set ensures an adequate coverage of the diversity of event waveforms which is due to the reservoir's highly complex fault system and the close observation distance. To cope with the increased computational demand of scanning 11-years of data with 2'500 templates, we parallelized our detector to run on a high-performance computer of the Swiss National Supercomputing Centre.We detect more than 200'000 events down to ML-2.5 during the six-day-long stimulation in December 2006 alone. Previously, only 13'000 detections found by an amplitude-threshold-based detector were known for this period. The high temporal and spatial resolution of this new catalog allows us to analyze the statistics of the induced Basel earthquakes in great detail. We resolve spatio-temporal variations of the seismicity parameters (a- and b-value) that have not been identified before and derive the first high-resolution temporal evolution of the seismic hazard for the Basel EGS reservoir.In summer 2017, our detector monitored the 10-week pressure reduction operation at the Basel-1 borehole during which the well was periodically opened. The detections drove a traffic light system based on magnitude thresholds and earthquake rates. For future EGS projects in Switzerland, our detector is planned to run in near real-time and provide the basis for an advanced traffic light system.

3D high- and super-resolution imaging using single-objective SPIM.

PubMed

Galland, Remi; Grenci, Gianluca; Aravind, Ajay; Viasnoff, Virgile; Studer, Vincent; Sibarita, Jean-Baptiste

2015-07-01

Single-objective selective-plane illumination microscopy (soSPIM) is achieved with micromirrored cavities combined with a laser beam-steering unit installed on a standard inverted microscope. The illumination and detection are done through the same objective. soSPIM can be used with standard sample preparations and features high background rejection and efficient photon collection, allowing for 3D single-molecule-based super-resolution imaging of whole cells or cell aggregates. Using larger mirrors enabled us to broaden the capabilities of our system to image Drosophila embryos.

Detection of the level of fluoride in the commercially available toothpaste using laser induced breakdown spectroscopy with the marker atomic transition line of neutral fluorine at 731.1 nm

NASA Astrophysics Data System (ADS)

Gondal, M. A.; Maganda, Y. W.; Dastageer, M. A.; Al Adel, F. F.; Naqvi, A. A.; Qahtan, T. F.

2014-04-01

Fourth harmonic of a pulsed Nd:YAG laser (wavelength 266 nm) in combination with high resolution spectrograph equipped with Gated ICCD camera has been employed to design a high sensitive analytical system. This detection system is based on Laser Induced Breakdown Spectroscopy and has been tested first time for analysis of semi-fluid samples to detect fluoride content present in the commercially available toothpaste samples. The experimental parameters were optimized to achieve an optically thin and in local thermo dynamic equilibrium plasma. This improved the limits of detection of fluoride present in tooth paste samples. The strong atomic transition line of fluorine at 731.102 nm was used as the marker line to quantify the fluoride concentration levels. Our LIBS system was able to detect fluoride concentration levels in the range of 1300-1750 ppm with a detection limit of 156 ppm.

High signal-to-noise-ratio electro-optical terahertz imaging system based on an optical demodulating detector array.

PubMed

Spickermann, Gunnar; Friederich, Fabian; Roskos, Hartmut G; Bolívar, Peter Haring

2009-11-01

We present a 64x48 pixel 2D electro-optical terahertz (THz) imaging system using a photonic mixing device time-of-flight camera as an optical demodulating detector array. The combination of electro-optic detection with a time-of-flight camera increases sensitivity drastically, enabling the use of a nonamplified laser source for high-resolution real-time THz electro-optic imaging.

Portable wireless electrocorticography system with a flexible microelectrodes array for epilepsy treatment.

PubMed

Xie, Kejun; Zhang, Shaomin; Dong, Shurong; Li, Shijian; Yu, Chaonan; Xu, Kedi; Chen, Wanke; Guo, Wei; Luo, Jikui; Wu, Zhaohui

2017-08-10

In this paper, we present a portable wireless electrocorticography (ECoG) system. It uses a high resolution 32-channel flexible ECoG electrodes array to collect electrical signals of brain activities and to stimulate the lesions. Electronic circuits are designed for signal acquisition, processing and transmission using Bluetooth Low Energy 4 (LTE4) for wireless communication with cell phone. In-vivo experiments on a rat show that the flexible ECoG system can accurately record electrical signals of brain activities and transmit them to cell phone with a maximal sampling rate of 30 ksampling/s per channel. It demonstrates that the epilepsy lesions can be detected, located and treated through the ECoG system. The wireless ECoG system has low energy consumption and high brain spatial resolution, thus has great prospects for future application.

High definition versus standard definition white light endoscopy for detecting dysplasia in patients with Barrett's esophagus.

PubMed

Sami, S S; Subramanian, V; Butt, W M; Bejkar, G; Coleman, J; Mannath, J; Ragunath, K

2015-01-01

High-definition endoscopy systems provide superior image resolution. The aim of this study was to assess the utility of high definition compared with standard definition endoscopy system for detecting dysplastic lesions in patients with Barrett's esophagus. A retrospective cohort study of patients with non-dysplastic Barrett's esophagus undergoing routine surveillance was performed. Data were retrieved from the central hospital electronic database. Procedures performed for non-surveillance indications, Barrett's esophagus Prague C0M1 classification with no specialized intestinal metaplasia on histology, patients diagnosed with any dysplasia or cancer on index endoscopy, and procedures using advanced imaging techniques were excluded. Logistic regression models were constructed to estimate adjusted odds ratios and 95% confidence intervals comparing outcomes with standard definition and high-definition systems. The high definition was superior to standard definition system in targeted detection of all dysplastic lesions (odds ratio 3.27, 95% confidence interval 1.27-8.40) as well as overall dysplasia detected on both random and target biopsies (odds ratio 2.36, 95% confidence interval 1.50-3.72). More non-dysplastic lesions were detected with the high-definition system (odds ratio 1.16, 95% confidence interval 1.01-1.33). There was no difference between high definition and standard definition endoscopy in the overall (random and target) high-grade dysplasia or cancers detected (odds ratio 0.93, 95% confidence interval 0.83-1.04). Trainee endoscopists, number of biopsies taken, and male sex were all significantly associated with a higher yield for dysplastic lesions. The use of the high-definition endoscopy system is associated with better targeted detection of any dysplasia during routine Barrett's esophagus surveillance. However, high-definition endoscopy cannot replace random biopsies at present time. © 2014 International Society for Diseases of the Esophagus.

Low-resolution ship detection from high-altitude aerial images

NASA Astrophysics Data System (ADS)

Qi, Shengxiang; Wu, Jianmin; Zhou, Qing; Kang, Minyang

2018-02-01

Ship detection from optical images taken by high-altitude aircrafts such as unmanned long-endurance airships and unmanned aerial vehicles has broad applications in marine fishery management, ship monitoring and vessel salvage. However, the major challenge is the limited capability of information processing on unmanned high-altitude platforms. Furthermore, in order to guarantee the wide detection range, unmanned aircrafts generally cruise at high altitudes, resulting in imagery with low-resolution targets and strong clutters suffered by heavy clouds. In this paper, we propose a low-resolution ship detection method to extract ships from these high-altitude optical images. Inspired by a recent research on visual saliency detection indicating that small salient signals could be well detected by a gradient enhancement operation combined with Gaussian smoothing, we propose the facet kernel filtering to rapidly suppress cluttered backgrounds and delineate candidate target regions from the sea surface. Then, the principal component analysis (PCA) is used to compute the orientation of the target axis, followed by a simplified histogram of oriented gradient (HOG) descriptor to characterize the ship shape property. Finally, support vector machine (SVM) is applied to discriminate real targets and false alarms. Experimental results show that the proposed method actually has high efficiency in low-resolution ship detection.

Automatic panoramic thermal integrated sensor

NASA Astrophysics Data System (ADS)

Gutin, Mikhail A.; Tsui, Eddy K.; Gutin, Olga N.

2005-05-01

Historically, the US Army has recognized the advantages of panoramic imagers with high image resolution: increased area coverage with fewer cameras, instantaneous full horizon detection, location and tracking of multiple targets simultaneously, extended range, and others. The novel ViperViewTM high-resolution panoramic thermal imager is the heart of the Automatic Panoramic Thermal Integrated Sensor (APTIS), being jointly developed by Applied Science Innovative, Inc. (ASI) and the Armament Research, Development and Engineering Center (ARDEC) in support of the Future Combat Systems (FCS) and the Intelligent Munitions Systems (IMS). The APTIS is anticipated to operate as an intelligent node in a wireless network of multifunctional nodes that work together to improve situational awareness (SA) in many defense and offensive operations, as well as serve as a sensor node in tactical Intelligence Surveillance Reconnaissance (ISR). The ViperView is as an aberration-corrected omnidirectional imager with small optics designed to match the resolution of a 640x480 pixels IR camera with improved image quality for longer range target detection, classification, and tracking. The same approach is applicable to panoramic cameras working in the visible spectral range. Other components of the ATPIS sensor suite include ancillary sensors, advanced power management, and wakeup capability. This paper describes the development status of the APTIS system.

Development of a novel depth of interaction PET detector using highly multiplexed G-APD cross-strip encoding

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kolb, A., E-mail: armin.kolb@med.uni-tuebingen.de; Parl, C.; Liu, C. C.

Purpose: The aim of this study was to develop a prototype PET detector module for a combined small animal positron emission tomography and magnetic resonance imaging (PET/MRI) system. The most important factor for small animal imaging applications is the detection sensitivity of the PET camera, which can be optimized by utilizing longer scintillation crystals. At the same time, small animal PET systems must yield a high spatial resolution. The measured object is very close to the PET detector because the bore diameter of a high field animal MR scanner is limited. When used in combination with long scintillation crystals, thesemore » small-bore PET systems generate parallax errors that ultimately lead to a decreased spatial resolution. Thus, we developed a depth of interaction (DoI) encoding PET detector module that has a uniform spatial resolution across the whole field of view (FOV), high detection sensitivity, compactness, and insensitivity to magnetic fields. Methods: The approach was based on Geiger mode avalanche photodiode (G-APD) detectors with cross-strip encoding. The number of readout channels was reduced by a factor of 36 for the chosen block elements. Two 12 × 2 G-APD strip arrays (25μm cells) were placed perpendicular on each face of a 12 × 12 lutetium oxyorthosilicate crystal block with a crystal size of 1.55 × 1.55 × 20 mm. The strip arrays were multiplexed into two channels and used to calculate the x, y coordinates for each array and the deposited energy. The DoI was measured in step sizes of 1.8 mm by a collimated {sup 18}F source. The coincident resolved time (CRT) was analyzed at all DoI positions by acquiring the waveform for each event and applying a digital leading edge discriminator. Results: All 144 crystals were well resolved in the crystal flood map. The average full width half maximum (FWHM) energy resolution of the detector was 12.8% ± 1.5% with a FWHM CRT of 1.14 ± 0.02 ns. The average FWHM DoI resolution over 12 crystals was 2.90 ± 0.15 mm. Conclusions: The novel DoI PET detector, which is based on strip G-APD arrays, yielded a DoI resolution of 2.9 mm and excellent timing and energy resolution. Its high multiplexing factor reduces the number of electronic channels. Thus, this cross-strip approach enables low-cost, high-performance PET detectors for dedicated small animal PET and PET/MRI and potentially clinical PET/MRI systems.« less

High sensitivity optical molecular imaging system

NASA Astrophysics Data System (ADS)

An, Yu; Yuan, Gao; Huang, Chao; Jiang, Shixin; Zhang, Peng; Wang, Kun; Tian, Jie

2018-02-01

Optical Molecular Imaging (OMI) has the advantages of high sensitivity, low cost and ease of use. By labeling the regions of interest with fluorescent or bioluminescence probes, OMI can noninvasively obtain the distribution of the probes in vivo, which play the key role in cancer research, pharmacokinetics and other biological studies. In preclinical and clinical application, the image depth, resolution and sensitivity are the key factors for researchers to use OMI. In this paper, we report a high sensitivity optical molecular imaging system developed by our group, which can improve the imaging depth in phantom to nearly 5cm, high resolution at 2cm depth, and high image sensitivity. To validate the performance of the system, special designed phantom experiments and weak light detection experiment were implemented. The results shows that cooperated with high performance electron-multiplying charge coupled device (EMCCD) camera, precision design of light path system and high efficient image techniques, our OMI system can simultaneously collect the light-emitted signals generated by fluorescence molecular imaging, bioluminescence imaging, Cherenkov luminance and other optical imaging modality, and observe the internal distribution of light-emitting agents fast and accurately.

High resolution MR based polymer dosimetry versus film densitometry: a systematic study based on the modulation transfer function approach.

PubMed

Berg, A; Pernkopf, M; Waldhäusl, C; Schmidt, W; Moser, E

2004-09-07

Precise methods of modem radiation therapy such as intensity modulated radiotherapy (IMRT), brachytherapy (BT) and high LET irradiation allow for high dose localization in volumes of a few mm3. However, most dosimetry methods-ionization chambers, TLD arrangements or silicon detectors, for example-are not capable of detecting sub-mm dose variations or do not allow for simple dose imaging. Magnetic resonance based polymer dosimetry (MRPD) appears to be well suited to three-dimensional high resolution relative dosimetry but the spatial resolution based on a systematic modulation transfer function (MTF) approach has not yet been investigated. We offer a theoretical construct for addressing the spatial resolution in different dose imaging systems, i.e. the dose modulation transfer function (DMTF) approach, an experimental realization of this concept with a phantom and quantitative comparisons between two dosimetric systems: polymer gel and film dosimetry. Polymer gel samples were irradiated by Co-60 photons through an absorber grid which is characterized by periodic structures of different spatial period (a), the smallest one at width of a/2 = 280 microm. The modulation in dose under the grid is visualized via calibrated, high resolution, parameter-selective (T2) and dose images based on multi-echo MR imaging. The DMTF is obtained from the modulation depth of the spin-spin relaxation time (T2) after calibration. Voxel sizes below 0.04 mm3 could be achieved, which are significantly smaller than those reported in MR based dose imaging on polymer gels elsewhere, using a powerful gradient system and a highly sensitive small birdcage resonator on a whole-body 3T MR scanner. Dose modulations at 22% of maximum dose amplitude could be observed at about 2 line pairs per mm. The polymer DMTF results are compared to those of a typical clinical film-scanner system. This study demonstrates that MR based gel dosimetry at 200 microm pixel resolution might even be superior, with reference to relative spatial resolution, to the results of a standard film-scanner system offering a nominal scan resolution of 200 microm.

Bayesian Peptide Peak Detection for High Resolution TOF Mass Spectrometry.

PubMed

Zhang, Jianqiu; Zhou, Xiaobo; Wang, Honghui; Suffredini, Anthony; Zhang, Lin; Huang, Yufei; Wong, Stephen

2010-11-01

In this paper, we address the issue of peptide ion peak detection for high resolution time-of-flight (TOF) mass spectrometry (MS) data. A novel Bayesian peptide ion peak detection method is proposed for TOF data with resolution of 10 000-15 000 full width at half-maximum (FWHW). MS spectra exhibit distinct characteristics at this resolution, which are captured in a novel parametric model. Based on the proposed parametric model, a Bayesian peak detection algorithm based on Markov chain Monte Carlo (MCMC) sampling is developed. The proposed algorithm is tested on both simulated and real datasets. The results show a significant improvement in detection performance over a commonly employed method. The results also agree with expert's visual inspection. Moreover, better detection consistency is achieved across MS datasets from patients with identical pathological condition.

Bayesian Peptide Peak Detection for High Resolution TOF Mass Spectrometry

PubMed Central

Zhang, Jianqiu; Zhou, Xiaobo; Wang, Honghui; Suffredini, Anthony; Zhang, Lin; Huang, Yufei; Wong, Stephen

2011-01-01

In this paper, we address the issue of peptide ion peak detection for high resolution time-of-flight (TOF) mass spectrometry (MS) data. A novel Bayesian peptide ion peak detection method is proposed for TOF data with resolution of 10 000–15 000 full width at half-maximum (FWHW). MS spectra exhibit distinct characteristics at this resolution, which are captured in a novel parametric model. Based on the proposed parametric model, a Bayesian peak detection algorithm based on Markov chain Monte Carlo (MCMC) sampling is developed. The proposed algorithm is tested on both simulated and real datasets. The results show a significant improvement in detection performance over a commonly employed method. The results also agree with expert’s visual inspection. Moreover, better detection consistency is achieved across MS datasets from patients with identical pathological condition. PMID:21544266

BioMon: A Google Earth Based Continuous Biomass Monitoring System (Demo Paper)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vatsavai, Raju

2009-01-01

We demonstrate a Google Earth based novel visualization system for continuous monitoring of biomass at regional and global scales. This system is integrated with a back-end spatiotemporal data mining system that continuously detects changes using high temporal resolution MODIS images. In addition to the visualization, we demonstrate novel query features of the system that provides insights into the current conditions of the landscape.

High-resolution microendoscope for the detection of cervical neoplasia.

PubMed

Grant, Benjamin D; Schwarz, Richard A; Quang, Timothy; Schmeler, Kathleen M; Richards-Kortum, Rebecca

2015-01-01

Cervical cancer causes 275,000 deaths each year with 85 % of these deaths occurring in the developing world. One of the primary reasons for the concentration of deaths in developing countries is a lack of effective screening methods suited for the infrastructure of these countries. In order to address this need, we have developed a high-resolution microendoscope (HRME). The HRME is a fiber-based fluorescence microscope with subcellular resolution. Using the vital stain proflavine, we are able to image cell nuclei in vivo and evaluate metrics such as nuclear-to-cytoplasmic ratio, critical to identifying precancerous epithelial regions. In this chapter, we detail the materials and methods necessary to build this system from commercially available parts.

On precise phase difference measurement approach using border stability of detection resolution.

PubMed

Bai, Lina; Su, Xin; Zhou, Wei; Ou, Xiaojuan

2015-01-01

For the precise phase difference measurement, this paper develops an improved dual phase coincidence detection method. The measurement resolution of the digital phase coincidence detection circuits is always limited, for example, only at the nanosecond level. This paper reveals a new way to improve the phase difference measurement precision by using the border stability of the circuit detection fuzzy areas. When a common oscillator signal is used to detect the phase coincidence with the two comparison signals, there will be two detection fuzzy areas for the reason of finite detection resolution surrounding the strict phase coincidence. Border stability of fuzzy areas and the fluctuation difference of the two fuzzy areas can be even finer than the picoseconds level. It is shown that the system resolution obtained only depends on the stability of the circuit measurement resolution which is much better than the measurement device resolution itself.

Adapting Raman Spectra from Laboratory Spectrometers to Portable Detection Libraries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weatherall, James; Barber, Jeffrey B.; Brauer, Carolyn S.

2013-02-01

Raman spectral data collected with high-resolution laboratory spectrometers are processed into a for- mat suitable for importing as a user library on a 1064nm DeltaNu rst generation, eld-deployable spectrometer prototype. The two laboratory systems used are a 1064nm Bruker spectrometer and a 785nm Kaiser spectrometer. The steps taken to compensate for device-dependent spectral resolution, wavenumber shifts between instruments, and wavenumber sensitivity variation are described.

High-Resolution EUV Spectroscopy of White Dwarfs

NASA Astrophysics Data System (ADS)

Kowalski, Michael P.; Wood, K. S.; Barstow, M. A.

2014-01-01

We compare results of high-resolution EUV spectroscopic measurements of the isolated white dwarf G191-B2B and the binary system Feige 24 obtained with the J-PEX (Joint Plasmadynamic Experiment), which was sponsored jointly by the U.S. Naval Research Laboratory and NASA. J-PEX delivers the world's highest resolution in EUV and does so at high effective area (e.g., more effective area in a sounding rocket than is available with Chandra at adjacent energies, but in a waveband Chandra cannot reach). The capability J-PEX represents is applicable to the astrophysics of hot plasmas in stellar coronae, white dwarfs and the ISM. G191-B2B and Feige 24 are quite distinct hot white dwarf systems having in common that they are bright in the portion of the EUV where He emission features and edges occur, hence they can be exploited to probe both the stellar atmosphere and the ISM, separating those components by model-fitting that sums over all relevant (He) spectral features in the band. There is evidence from these fits that atmospheric He is being detected but the result is more conservatively cast as a pair of upper limits. We discuss how longer duration satellite observations with the same instrumentation could increase exposure to detect atmospheric He in these and other nearby hot white dwarfs.

Integrated analysis of copy number alteration and RNA expression profiles of cancer using a high-resolution whole-genome oligonucleotide array.

PubMed

Jung, Seung-Hyun; Shin, Seung-Hun; Yim, Seon-Hee; Choi, Hye-Sun; Lee, Sug-Hyung; Chung, Yeun-Jun

2009-07-31

Recently, microarray-based comparative genomic hybridization (array-CGH) has emerged as a very efficient technology with higher resolution for the genome-wide identification of copy number alterations (CNA). Although CNAs are thought to affect gene expression, there is no platform currently available for the integrated CNA-expression analysis. To achieve high-resolution copy number analysis integrated with expression profiles, we established human 30k oligoarray-based genome-wide copy number analysis system and explored the applicability of this system for integrated genome and transcriptome analysis using MDA-MB-231 cell line. We compared the CNAs detected by the oligoarray with those detected by the 3k BAC array for validation. The oligoarray identified the single copy difference more accurately and sensitively than the BAC array. Seventeen CNAs detected by both platforms in MDA-MB-231 such as gains of 5p15.33-13.1, 8q11.22-8q21.13, 17p11.2, and losses of 1p32.3, 8p23.3-8p11.21, and 9p21 were consistently identified in previous studies on breast cancer. There were 122 other small CNAs (mean size 1.79 mb) that were detected by oligoarray only, not by BAC-array. We performed genomic qPCR targeting 7 CNA regions, detected by oligoarray only, and one non-CNA region to validate the oligoarray CNA detection. All qPCR results were consistent with the oligoarray-CGH results. When we explored the possibility of combined interpretation of both DNA copy number and RNA expression profiles, mean DNA copy number and RNA expression levels showed a significant correlation. In conclusion, this 30k oligoarray-CGH system can be a reasonable choice for analyzing whole genome CNAs and RNA expression profiles at a lower cost.

Propellant Feed System Leak Detection: Lessons Learned From the Linear Aerospike SR-71 Experiment (LASRE)

NASA Technical Reports Server (NTRS)

Hass, Neal; Mizukami, Masashi; Neal, Bradford A.; St. John, Clinton; Beil, Robert J.; Griffin, Timothy P.

1999-01-01

This paper presents pertinent results and assessment of propellant feed system leak detection as applied to the Linear Aerospike SR-71 Experiment (LASRE) program flown at the NASA Dryden Flight Research Center, Edwards, California. The LASRE was a flight test of an aerospike rocket engine using liquid oxygen and high-pressure gaseous hydrogen as propellants. The flight safety of the crew and the experiment demanded proven technologies and techniques that could detect leaks and assess the integrity of hazardous propellant feed systems. Point source detection and systematic detection were used. Point source detection was adequate for catching gross leakage from components of the propellant feed systems, but insufficient for clearing LASRE to levels of acceptability. Systematic detection, which used high-resolution instrumentation to evaluate the health of the system within a closed volume, provided a better means for assessing leak hazards. Oxygen sensors detected a leak rate of approximately 0.04 cubic inches per second of liquid oxygen. Pressure sensor data revealed speculated cryogenic boiloff through the fittings of the oxygen system, but location of the source(s) was indeterminable. Ultimately, LASRE was cancelled because leak detection techniques were unable to verify that oxygen levels could be maintained below flammability limits.

Detecting breast microcalcifications using super-resolution ultrasound imaging: a clinical study

NASA Astrophysics Data System (ADS)

Huang, Lianjie; Labyed, Yassin; Hanson, Kenneth; Sandoval, Daniel; Pohl, Jennifer; Williamson, Michael

2013-03-01

Imaging breast microcalcifications is crucial for early detection and diagnosis of breast cancer. It is challenging for current clinical ultrasound to image breast microcalcifications. However, new imaging techniques using data acquired with a synthetic-aperture ultrasound system have the potential to significantly improve ultrasound imaging. We recently developed a super-resolution ultrasound imaging method termed the phase-coherent multiple-signal classification (PC-MUSIC). This signal subspace method accounts for the phase response of transducer elements to improve image resolution. In this paper, we investigate the clinical feasibility of our super-resolution ultrasound imaging method for detecting breast microcalcifications. We use our custom-built, real-time synthetic-aperture ultrasound system to acquire breast ultrasound data for 40 patients whose mammograms show the presence of breast microcalcifications. We apply our super-resolution ultrasound imaging method to the patient data, and produce clear images of breast calcifications. Our super-resolution ultrasound PC-MUSIC imaging with synthetic-aperture ultrasound data can provide a new imaging modality for detecting breast microcalcifications in clinic without using ionizing radiation.

HIGH-RESOLUTION IMAGES OF ORBITAL MOTION IN THE ORION TRAPEZIUM CLUSTER WITH THE LBT AO SYSTEM

DOE Office of Scientific and Technical Information (OSTI.GOV)

Close, L. M.; Males, J. R.; Skemer, A.

2012-04-20

The new 8.4 m LBT adaptive secondary AO system, with its novel pyramid wavefront sensor, was used to produce very high Strehl ({approx}> 75% at 2.16 {mu}m) near-infrared narrowband (Br{gamma}: 2.16 {mu}m and [Fe II]: 1.64 {mu}m) images of 47 young ({approx}1 Myr) Orion Trapezium {theta}{sup 1} Ori cluster members. The inner {approx}41 Multiplication-Sign 53'' of the cluster was imaged at spatial resolutions of {approx}0.''050 (at 1.64 {mu}m). A combination of high spatial resolution and high S/N yielded relative binary positions to {approx}0.5 mas accuracies. Including previous speckle data, we analyze a 15 year baseline of high-resolution observations of thismore » cluster. We are now sensitive to relative proper motions of just {approx}0.3 mas yr{sup -1} (0.6 km s{sup -1} at 450 pc); this is a {approx}7 Multiplication-Sign improvement in orbital velocity accuracy compared to previous efforts. We now detect clear orbital motions in the {theta}{sup 1} Ori B{sub 2} B{sub 3} system of 4.9 {+-} 0.3 km s{sup -1} and 7.2 {+-} 0.8 km s{sup -1} in the {theta}{sup 1} Ori A{sub 1} A{sub 2} system (with correlations of P.A. versus time at >99% confidence). All five members of the {theta}{sup 1} Ori B system appear likely a gravitationally bound 'mini-cluster'. The very lowest mass member of the {theta}{sup 1} Ori B system (B{sub 4}; mass {approx}0.2 M{sub Sun }) has, for the first time, a clearly detected motion (at 4.3 {+-} 2.0 km s{sup -1}; correlation = 99.7%) w.r.t. B{sub 1}. However, B{sub 4} is most likely in a long-term unstable (non-hierarchical) orbit and may 'soon' be ejected from this 'mini-cluster'. This 'ejection' process could play a major role in the formation of low-mass stars and brown dwarfs.« less

Generic Sensor Modeling Using Pulse Method

NASA Technical Reports Server (NTRS)

Helder, Dennis L.; Choi, Taeyoung

2005-01-01

Recent development of high spatial resolution satellites such as IKONOS, Quickbird and Orbview enable observation of the Earth's surface with sub-meter resolution. Compared to the 30 meter resolution of Landsat 5 TM, the amount of information in the output image was dramatically increased. In this era of high spatial resolution, the estimation of spatial quality of images is gaining attention. Historically, the Modulation Transfer Function (MTF) concept has been used to estimate an imaging system's spatial quality. Sometimes classified by target shapes, various methods were developed in laboratory environment utilizing sinusoidal inputs, periodic bar patterns and narrow slits. On-orbit sensor MTF estimation was performed on 30-meter GSD Landsat4 Thematic Mapper (TM) data from the bridge pulse target as a pulse input . Because of a high resolution sensor s small Ground Sampling Distance (GSD), reasonably sized man-made edge, pulse, and impulse targets can be deployed on a uniform grassy area with accurate control of ground targets using tarps and convex mirrors. All the previous work cited calculated MTF without testing the MTF estimator's performance. In previous report, a numerical generic sensor model had been developed to simulate and improve the performance of on-orbit MTF estimating techniques. Results from the previous sensor modeling report that have been incorporated into standard MTF estimation work include Fermi edge detection and the newly developed 4th order modified Savitzky-Golay (MSG) interpolation technique. Noise sensitivity had been studied by performing simulations on known noise sources and a sensor model. Extensive investigation was done to characterize multi-resolution ground noise. Finally, angle simulation was tested by using synthetic pulse targets with angles from 2 to 15 degrees, several brightness levels, and different noise levels from both ground targets and imaging system. As a continuing research activity using the developed sensor model, this report was dedicated to MTF estimation via pulse input method characterization using the Fermi edge detection and 4th order MSG interpolation method. The relationship between pulse width and MTF value at Nyquist was studied including error detection and correction schemes. Pulse target angle sensitivity was studied by using synthetic targets angled from 2 to 12 degrees. In this report, from the ground and system noise simulation, a minimum SNR value was suggested for a stable MTF value at Nyquist for the pulse method. Target width error detection and adjustment technique based on a smooth transition of MTF profile is presented, which is specifically applicable only to the pulse method with 3 pixel wide targets.

High spatial resolution distributed fiber system for multi-parameter sensing based on modulated pulses.

PubMed

Zhang, Jingdong; Zhu, Tao; Zhou, Huan; Huang, Shihong; Liu, Min; Huang, Wei

2016-11-28

We demonstrate a cost-effective distributed fiber sensing system for the multi-parameter detection of the vibration, the temperature, and the strain by integrating phase-sensitive optical time domain reflectometry (φ-OTDR) and Brillouin optical time domain reflectometry (B-OTDR). Taking advantage of the fast changing property of the vibration and the static properties of the temperature and the strain, both the width and intensity of the laser pulses are modulated and injected into the single-mode sensing fiber proportionally, so that three concerned parameters can be extracted simultaneously by only one photo-detector and one data acquisition channel. A data processing method based on Gaussian window short time Fourier transform (G-STFT) is capable of achieving high spatial resolution in B-OTDR. The experimental results show that up to 4.8kHz vibration sensing with 3m spatial resolution at 10km standard single-mode fiber can be realized, as well as the distributed temperature and stress profiles along the same fiber with 80cm spatial resolution.

Conception and realization of a semiconductor based 240 GHz full 3D MIMO imaging system

NASA Astrophysics Data System (ADS)

Weisenstein, Christian; Kahl, Matthias; Friederich, Fabian; Haring Bolívar, Peter

2017-02-01

Multiple-input multiple-output (MIMO) imaging systems in the terahertz frequency range have a high potential in the field of non-destructive testing (NDT). With such systems it is possible to detect defects in composite materials, for example cracks or delaminations in fiber composites. To investigate mass-produced products it is necessary to study the objects in close to real-time on a conveyor without affecting the production cycle time. In this work we present the conception and realization of a 3D MIMO imaging system for in-line investigation of composite materials and structures. To achieve a lateral resolution of 1 mm, in order to detect such small defects in composite materials with a moderate number of elements, precise sensor design is crucial. In our approach we use the effective aperture concept. The designed sparse array consists of 32 transmitters and 30 receivers based on planar semiconductor components. High range resolution is achieved by an operating frequency between 220 GHz and 260 GHz in a stepped frequency continuous wave (SFCW) setup. A matched filter approach is used to simulate the reconstructed 3D image through the array. This allows the evaluation of the designed array geometry in regard of resolution and side lobe level. In contrast to earlier demonstrations, in which synthetic reconstruction is only performed in a 2D plane, an optics-free full 3D recon- struction has been implemented in our concept. Based on this simulation we designed an array geometry that enables to resolve objects with a resolution smaller than 1mm and moderate side lobe level.

Video-rate functional photoacoustic microscopy at depths

NASA Astrophysics Data System (ADS)

Wang, Lidai; Maslov, Konstantin; Xing, Wenxin; Garcia-Uribe, Alejandro; Wang, Lihong V.

2012-10-01

We report the development of functional photoacoustic microscopy capable of video-rate high-resolution in vivo imaging in deep tissue. A lightweight photoacoustic probe is made of a single-element broadband ultrasound transducer, a compact photoacoustic beam combiner, and a bright-field light delivery system. Focused broadband ultrasound detection provides a 44-μm lateral resolution and a 28-μm axial resolution based on the envelope (a 15-μm axial resolution based on the raw RF signal). Due to the efficient bright-field light delivery, the system can image as deep as 4.8 mm in vivo using low excitation pulse energy (28 μJ per pulse, 0.35 mJ/cm2 on the skin surface). The photoacoustic probe is mounted on a fast-scanning voice-coil scanner to acquire 40 two-dimensional (2-D) B-scan images per second over a 9-mm range. High-resolution anatomical imaging is demonstrated in the mouse ear and brain. Via fast dual-wavelength switching, oxygen dynamics of mouse cardio-vasculature is imaged in realtime as well.

Development of a Coded Aperture X-Ray Backscatter Imager for Explosive Device Detection

NASA Astrophysics Data System (ADS)

Faust, Anthony A.; Rothschild, Richard E.; Leblanc, Philippe; McFee, John Elton

2009-02-01

Defence R&D Canada has an active research and development program on detection of explosive devices using nuclear methods. One system under development is a coded aperture-based X-ray backscatter imaging detector designed to provide sufficient speed, contrast and spatial resolution to detect antipersonnel landmines and improvised explosive devices. The successful development of a hand-held imaging detector requires, among other things, a light-weight, ruggedized detector with low power requirements, supplying high spatial resolution. The University of California, San Diego-designed HEXIS detector provides a modern, large area, high-temperature CZT imaging surface, robustly packaged in a light-weight housing with sound mechanical properties. Based on the potential for the HEXIS detector to be incorporated as the detection element of a hand-held imaging detector, the authors initiated a collaborative effort to demonstrate the capability of a coded aperture-based X-ray backscatter imaging detector. This paper will discuss the landmine and IED detection problem and review the coded aperture technique. Results from initial proof-of-principle experiments will then be reported.

Deep learning for classification of islanding and grid disturbance based on multi-resolution singular spectrum entropy

NASA Astrophysics Data System (ADS)

Li, Tie; He, Xiaoyang; Tang, Junci; Zeng, Hui; Zhou, Chunying; Zhang, Nan; Liu, Hui; Lu, Zhuoxin; Kong, Xiangrui; Yan, Zheng

2018-02-01

Forasmuch as the distinguishment of islanding is easy to be interfered by grid disturbance, island detection device may make misjudgment thus causing the consequence of photovoltaic out of service. The detection device must provide with the ability to differ islanding from grid disturbance. In this paper, the concept of deep learning is introduced into classification of islanding and grid disturbance for the first time. A novel deep learning framework is proposed to detect and classify islanding or grid disturbance. The framework is a hybrid of wavelet transformation, multi-resolution singular spectrum entropy, and deep learning architecture. As a signal processing method after wavelet transformation, multi-resolution singular spectrum entropy combines multi-resolution analysis and spectrum analysis with entropy as output, from which we can extract the intrinsic different features between islanding and grid disturbance. With the features extracted, deep learning is utilized to classify islanding and grid disturbance. Simulation results indicate that the method can achieve its goal while being highly accurate, so the photovoltaic system mistakenly withdrawing from power grids can be avoided.

Characterization of a sub-assembly of 3D position sensitive cadmium zinc telluride detectors and electronics from a sub-millimeter resolution PET system.

PubMed

Abbaszadeh, Shiva; Gu, Yi; Reynolds, Paul D; Levin, Craig S

2016-09-21

Cadmium zinc telluride (CZT) offers key advantages for small animal positron emission tomography (PET), including high spatial and energy resolution and simple metal deposition for fabrication of very small pixel arrays. Previous studies have investigated the intrinsic spatial, energy, and timing resolution of an individual sub-millimeter resolution CZT detector. In this work we present the first characterization results of a system of these detectors. The 3D position sensitive dual-CZT detector module and readout electronics developed in our lab was scaled up to complete a significant portion of the final PET system. This sub-system was configured as two opposing detection panels containing a total of twelve [Formula: see text] mm monolithic CZT crystals for proof of concept. System-level characterization studies, including optimizing the trigger threshold of each channel's comparators, were performed. 68 Ge and 137 Cs radioactive isotopes were used to characterize the energy resolution of all 468 anode channels in the sub-system. The mean measured global 511 keV photopeak energy resolution over all anodes was found to be [Formula: see text]% FWHM after correction for photon interaction depth-dependent signal variation. The measured global time resolution was 37 ns FWHM, a parameter to be further optimized, and the intrinsic spatial resolution was 0.76 mm FWHM.

New imaging systems in nuclear medicine. Final report, January 1, 1993--December 31, 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-12-31

The aim of this program has been to improve the performance of positron emission tomography (PET) to achieve high resolution with high sensitivity. Towards this aim, the authors have carried out the following studies: (1) explored new techniques for detection of annihilation radiation including new detector materials and system geometries, specific areas that they have studied include--exploration of factors related to resolution and sensitivity of PET instrumentation including geometry, detection materials and coding, and the exploration of technique to improve the image quality by use of depth of interaction and increased sampling; (2) complete much of the final testing ofmore » PCR-II, an analog-coded cylindrical positron tomograph, developed and constructed during the current funding period; (3) developed the design of a positron microtomograph with mm resolution for quantitative studies in small animals, a single slice version of this device has been designed and studied by use of computer simulation; (4) continued and expanded the program of biological studies in animal models. Current studies have included imaging of animal models of Parkinson`s and Huntington`s disease and cancer. These studies have included new radiopharmaceuticals and techniques involving molecular biology.« less

Highly sensitive detection of naphthalene in solvent vapor using a functionalized PBG refractive index sensor.

PubMed

Girschikofsky, Maiko; Rosenberger, Manuel; Belle, Stefan; Brutschy, Malte; Waldvogel, Siegfried R; Hellmann, Ralf

2012-01-01

We report an optical refractive index sensor system based on a planar Bragg grating which is functionalized by substituted γ-cyclodextrin to determine low concentrations of naphthalene in solvent vapor. The sensor system exhibits a quasi-instantaneous shift of the Bragg wavelength and is therefore capable for online detection. The overall shift of the Bragg wavelength reveals a linear relationship to the analyte concentration with a gradient of 12.5 ± 1.5 pm/ppm. Due to the spectral resolution and repeatability of the interrogation system, this corresponds to acquisition steps of 80 ppb. Taking into account the experimentally detected signal noise a minimum detection limit of 0.48 ± 0.05 ppm is deduced.

Long linear MWIR and LWIR HgCdTe infrared detection arrays for high resolution imaging

NASA Astrophysics Data System (ADS)

Chamonal, Jean-Paul; Audebert, Patrick; Medina, Philippe; Destefanis, Gérard; Deschamps, Joel R.; Girard, Michel; Chatard, Jean-Pierre

2018-04-01

This paper, "Long linear MWIR and LWIR HgCdTe infrared detection arrays for high resolution imaging," was presented as part of International Conference on Space Optics—ICSO 1997, held in Toulouse, France.

Deflection angle detecting system for the large-angle and high-linearity fast steering mirror using quadrant detector

NASA Astrophysics Data System (ADS)

Ni, Yingxue; Wu, Jiabin; San, Xiaogang; Gao, Shijie; Ding, Shaohang; Wang, Jing; Wang, Tao

2018-02-01

A deflection angle detecting system (DADS) using a quadrant detector (QD) is developed to achieve the large deflection angle and high linearity for the fast steering mirror (FSM). The mathematical model of the DADS is established by analyzing the principle of position detecting and error characteristics of the QD. Based on this mathematical model, the method of optimizing deflection angle and linearity of FSM is demonstrated, which is proved feasible by simulation and experimental results. Finally, a QD-based FSM is designed and tested. The results show that it achieves 0.72% nonlinearity, ±2.0 deg deflection angle, and 1.11-μrad resolution. Therefore, the application of this method will be beneficial to design the FSM.

Characterization of a time-resolved non-contact scanning diffuse optical imaging system exploiting fast-gated single-photon avalanche diode detection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Di Sieno, Laura, E-mail: laura.disieno@polimi.it; Dalla Mora, Alberto; Contini, Davide

2016-03-15

We present a system for non-contact time-resolved diffuse reflectance imaging, based on small source-detector distance and high dynamic range measurements utilizing a fast-gated single-photon avalanche diode. The system is suitable for imaging of diffusive media without any contact with the sample and with a spatial resolution of about 1 cm at 1 cm depth. In order to objectively assess its performances, we adopted two standardized protocols developed for time-domain brain imagers. The related tests included the recording of the instrument response function of the setup and the responsivity of its detection system. Moreover, by using liquid turbid phantoms with absorbingmore » inclusions, depth-dependent contrast and contrast-to-noise ratio as well as lateral spatial resolution were measured. To illustrate the potentialities of the novel approach, the characteristics of the non-contact system are discussed and compared to those of a fiber-based brain imager.« less

Coincidence electron/ion imaging with a fast frame camera

NASA Astrophysics Data System (ADS)

Li, Wen; Lee, Suk Kyoung; Lin, Yun Fei; Lingenfelter, Steven; Winney, Alexander; Fan, Lin

2015-05-01

A new time- and position- sensitive particle detection system based on a fast frame CMOS camera is developed for coincidence electron/ion imaging. The system is composed of three major components: a conventional microchannel plate (MCP)/phosphor screen electron/ion imager, a fast frame CMOS camera and a high-speed digitizer. The system collects the positional information of ions/electrons from a fast frame camera through real-time centroiding while the arrival times are obtained from the timing signal of MCPs processed by a high-speed digitizer. Multi-hit capability is achieved by correlating the intensity of electron/ion spots on each camera frame with the peak heights on the corresponding time-of-flight spectrum. Efficient computer algorithms are developed to process camera frames and digitizer traces in real-time at 1 kHz laser repetition rate. We demonstrate the capability of this system by detecting a momentum-matched co-fragments pair (methyl and iodine cations) produced from strong field dissociative double ionization of methyl iodide. We further show that a time resolution of 30 ps can be achieved when measuring electron TOF spectrum and this enables the new system to achieve a good energy resolution along the TOF axis.

High-Resolution Ultrasound-Switchable Fluorescence Imaging in Centimeter-Deep Tissue Phantoms with High Signal-To-Noise Ratio and High Sensitivity via Novel Contrast Agents

PubMed Central

Cheng, Bingbing; Bandi, Venugopal; Wei, Ming-Yuan; Pei, Yanbo; D’Souza, Francis; Nguyen, Kytai T.; Hong, Yi; Yuan, Baohong

2016-01-01

For many years, investigators have sought after high-resolution fluorescence imaging in centimeter-deep tissue because many interesting in vivo phenomena—such as the presence of immune system cells, tumor angiogenesis, and metastasis—may be located deep in tissue. Previously, we developed a new imaging technique to achieve high spatial resolution in sub-centimeter deep tissue phantoms named continuous-wave ultrasound-switchable fluorescence (CW-USF). The principle is to use a focused ultrasound wave to externally and locally switch on and off the fluorophore emission from a small volume (close to ultrasound focal volume). By making improvements in three aspects of this technique: excellent near-infrared USF contrast agents, a sensitive frequency-domain USF imaging system, and an effective signal processing algorithm, for the first time this study has achieved high spatial resolution (~ 900 μm) in 3-centimeter-deep tissue phantoms with high signal-to-noise ratio (SNR) and high sensitivity (3.4 picomoles of fluorophore in a volume of 68 nanoliters can be detected). We have achieved these results in both tissue-mimic phantoms and porcine muscle tissues. We have also demonstrated multi-color USF to image and distinguish two fluorophores with different wavelengths, which might be very useful for simultaneously imaging of multiple targets and observing their interactions in the future. This work has opened the door for future studies of high-resolution centimeter-deep tissue fluorescence imaging. PMID:27829050

High-Resolution Ultrasound-Switchable Fluorescence Imaging in Centimeter-Deep Tissue Phantoms with High Signal-To-Noise Ratio and High Sensitivity via Novel Contrast Agents.

PubMed

Cheng, Bingbing; Bandi, Venugopal; Wei, Ming-Yuan; Pei, Yanbo; D'Souza, Francis; Nguyen, Kytai T; Hong, Yi; Yuan, Baohong

2016-01-01

For many years, investigators have sought after high-resolution fluorescence imaging in centimeter-deep tissue because many interesting in vivo phenomena-such as the presence of immune system cells, tumor angiogenesis, and metastasis-may be located deep in tissue. Previously, we developed a new imaging technique to achieve high spatial resolution in sub-centimeter deep tissue phantoms named continuous-wave ultrasound-switchable fluorescence (CW-USF). The principle is to use a focused ultrasound wave to externally and locally switch on and off the fluorophore emission from a small volume (close to ultrasound focal volume). By making improvements in three aspects of this technique: excellent near-infrared USF contrast agents, a sensitive frequency-domain USF imaging system, and an effective signal processing algorithm, for the first time this study has achieved high spatial resolution (~ 900 μm) in 3-centimeter-deep tissue phantoms with high signal-to-noise ratio (SNR) and high sensitivity (3.4 picomoles of fluorophore in a volume of 68 nanoliters can be detected). We have achieved these results in both tissue-mimic phantoms and porcine muscle tissues. We have also demonstrated multi-color USF to image and distinguish two fluorophores with different wavelengths, which might be very useful for simultaneously imaging of multiple targets and observing their interactions in the future. This work has opened the door for future studies of high-resolution centimeter-deep tissue fluorescence imaging.

Design and application of an array extended blackbody

NASA Astrophysics Data System (ADS)

Zhang, Ya-zhou; Fan, Xiao-li; Lei, Hao; Zhou, Zhi-yuan

2018-02-01

An array extended blackbody is designed to quantitatively measure and evaluate the performance of infrared imaging systems. The theory, structure, control software and application of blackbody are introduced. The parameters of infrared imaging systems such as the maximum detectable range, detection sensitivity, spatial resolution and temperature resolution can be measured.

MPGD for breast cancer prevention: a high resolution and low dose radiation medical imaging

NASA Astrophysics Data System (ADS)

Gutierrez, R. M.; Cerquera, E. A.; Mañana, G.

2012-07-01

Early detection of small calcifications in mammograms is considered the best preventive tool of breast cancer. However, existing digital mammography with relatively low radiation skin exposure has limited accessibility and insufficient spatial resolution for small calcification detection. Micro Pattern Gaseous Detectors (MPGD) and associated technologies, increasingly provide new information useful to generate images of microscopic structures and make more accessible cutting edge technology for medical imaging and many other applications. In this work we foresee and develop an application for the new information provided by a MPGD camera in the form of highly controlled images with high dynamical resolution. We present a new Super Detail Image (S-DI) that efficiently profits of this new information provided by the MPGD camera to obtain very high spatial resolution images. Therefore, the method presented in this work shows that the MPGD camera with SD-I, can produce mammograms with the necessary spatial resolution to detect microcalcifications. It would substantially increase efficiency and accessibility of screening mammography to highly improve breast cancer prevention.

Fast Low-Cost Multiple Sensor Readout System

DOEpatents

Carter-Lewis, David; Krennich, Frank; Le Bohec, Stephane; Petry, Dirk; Sleege, Gary

2004-04-06

A low resolution data acquisition system is presented. The data acquisition system has a plurality of readout modules serially connected to a controller. Each readout module has a FPGA in communication with analog to digital (A/D) converters, which are connected to sensors. The A/D converter has eight bit or lower resolution. The FPGA detects when a command is addressed to it and commands the A/D converters to convert analog sensor data into digital data. The digital data is sent on a high speed serial communication bus to the controller. A graphical display is used in one embodiment to indicate if a sensor reading is outside of a predetermined range.

Non-interferometric deep optical resolution photoacoustic remote sensing microscopy (Conference Presentation)

NASA Astrophysics Data System (ADS)

HajiReza, Parsin H.; Bell, Kevan L.; Shi, Wei; Zemp, Roger J.

2017-03-01

A novel all-optical non-contact photoacoustic microscopy system is introduced. The confocal configuration is used to ensure detection of initial pressure shock wave-induced intensity reflections at the subsurface origin where pressures are largest. Phantom studies confirm signal dependence on optical absorption, index-contrast, and excitation fluence. Taking advantage of a focused1310 nm interrogation beam, the penetration depth of the system is improved to 2mm for an optical resolution system. High signal-to-noise ratios (>60dB) with 2.5 cm working distance from the objective lens to the sample is achieved. Real-time in-vivo imaging of microvasculature and melanoma tumors are demonstrated.

Performance study of large area encoding readout MRPC

NASA Astrophysics Data System (ADS)

Chen, X. L.; Wang, Y.; Chen, G.; Han, D.; Wang, X.; Zeng, M.; Zeng, Z.; Zhao, Z.; Guo, B.

2018-02-01

Muon tomography system built by the 2-D readout high spatial resolution Multi-gap Resistive Plate Chamber (MRPC) detector is a project of Tsinghua University. An encoding readout method based on the fine-fine configuration has been used to minimize the number of the readout electronic channels resulting in reducing the complexity and the cost of the system. In this paper, we provide a systematic comparison of the MRPC detector performance with and without fine-fine encoding readout. Our results suggest that the application of the fine-fine encoding readout leads us to achieve a detecting system with slightly worse spatial resolution but dramatically reduce the number of electronic channels.

"Phoswich Wall": A charged-particle detector array for inverse-kinematic reactions with the Gretina/GRETA γ-ray arrays

NASA Astrophysics Data System (ADS)

Sarantites, D. G.; Reviol, W.; Elson, J. M.; Kinnison, J. E.; Izzo, C. J.; Manfredi, J.; Liu, J.; Jung, H. S.; Goerres, J.

2015-08-01

A high-efficiency, forward-hemisphere detector system for light charged particles and low-Z heavy ions, as obtained in an accelerator experiment, is described. It consists of four 8×8 pixel multianode photomultiplier tubes with 2.2-mm thick CsI(Tl) and 12 -μm thick fast-plastic scintillation detectors. Its phoswich structure allows individual Z resolution for 1H, 4He, 7Li, 4He+4He, 9Be, 11B, 12C, and 14N ions, which are target-like fragments detected in strongly inverse kinematics. The device design has been optimized for use with a 4π γ-ray array, and the main applications are transfer reactions and Coulomb excitation. A high-angular resolution for the detection of the target-like fragments is achieved which permits angular distributions to be measured in the rest frame of the projectile-like fragment with a resolution of ~ 2 °.

A high throughput spectral image microscopy system

NASA Astrophysics Data System (ADS)

Gesley, M.; Puri, R.

2018-01-01

A high throughput spectral image microscopy system is configured for rapid detection of rare cells in large populations. To overcome flow cytometry rates and use of fluorophore tags, a system architecture integrates sample mechanical handling, signal processors, and optics in a non-confocal version of light absorption and scattering spectroscopic microscopy. Spectral images with native contrast do not require the use of exogeneous stain to render cells with submicron resolution. Structure may be characterized without restriction to cell clusters of differentiation.

Proceedings of the 2004 High Spatial Resolution Commercial Imagery Workshop

NASA Technical Reports Server (NTRS)

2006-01-01

Topics covered include: NASA Applied Sciences Program; USGS Land Remote Sensing: Overview; QuickBird System Status and Product Overview; ORBIMAGE Overview; IKONOS 2004 Calibration and Validation Status; OrbView-3 Spatial Characterization; On-Orbit Modulation Transfer Function (MTF) Measurement of QuickBird; Spatial Resolution Characterization for QuickBird Image Products 2003-2004 Season; Image Quality Evaluation of QuickBird Super Resolution and Revisit of IKONOS: Civil and Commercial Application Project (CCAP); On-Orbit System MTF Measurement; QuickBird Post Launch Geopositional Characterization Update; OrbView-3 Geometric Calibration and Geopositional Accuracy; Geopositional Statistical Methods; QuickBird and OrbView-3 Geopositional Accuracy Assessment; Initial On-Orbit Spatial Resolution Characterization of OrbView-3 Panchromatic Images; Laboratory Measurement of Bidirectional Reflectance of Radiometric Tarps; Stennis Space Center Verification and Validation Capabilities; Joint Agency Commercial Imagery Evaluation (JACIE) Team; Adjacency Effects in High Resolution Imagery; Effect of Pulse Width vs. GSD on MTF Estimation; Camera and Sensor Calibration at the USGS; QuickBird Geometric Verification; Comparison of MODTRAN to Heritage-based Results in Vicarious Calibration at University of Arizona; Using Remotely Sensed Imagery to Determine Impervious Surface in Sioux Falls, South Dakota; Estimating Sub-Pixel Proportions of Sagebrush with a Regression Tree; How Do YOU Use the National Land Cover Dataset?; The National Map Hazards Data Distribution System; Recording a Troubled World; What Does This-Have to Do with This?; When Can a Picture Save a Thousand Homes?; InSAR Studies of Alaska Volcanoes; Earth Observing-1 (EO-1) Data Products; Improving Access to the USGS Aerial Film Collections: High Resolution Scanners; Improving Access to the USGS Aerial Film Collections: Phoenix Digitizing System Product Distribution; System and Product Characterization: Issues Approach; Innovative Approaches to Analysis of Lidar Data for the National Map; Changes in Imperviousness near Military Installations; Geopositional Accuracy Evaluations of QuickBird and OrbView-3: Civil and Commercial Applications Project (CCAP); Geometric Accuracy Assessment: OrbView ORTHO Products; QuickBird Radiometric Calibration Update; OrbView-3 Radiometric Calibration; QuickBird Radiometric Characterization; NASA Radiometric Characterization; Establishing and Verifying the Traceability of Remote-Sensing Measurements to International Standards; QuickBird Applications; Airport Mapping and Perpetual Monitoring Using IKONOS; OrbView-3 Relative Accuracy Results and Impacts on Exploitation and Accuracy Improvement; Using Remotely Sensed Imagery to Determine Impervious Surface in Sioux Falls, South Dakota; Applying High-Resolution Satellite Imagery and Remotely Sensed Data to Local Government Applications: Sioux Falls, South Dakota; Automatic Co-Registration of QuickBird Data for Change Detection Applications; Developing Coastal Surface Roughness Maps Using ASTER and QuickBird Data Sources; Automated, Near-Real Time Cloud and Cloud Shadow Detection in High Resolution VNIR Imagery; Science Applications of High Resolution Imagery at the USGS EROS Data Center; Draft Plan for Characterizing Commercial Data Products in Support of Earth Science Research; Atmospheric Correction Prototype Algorithm for High Spatial Resolution Multispectral Earth Observing Imaging Systems; Determining Regional Arctic Tundra Carbon Exchange: A Bottom-Up Approach; Using IKONOS Imagery to Assess Impervious Surface Area, Riparian Buffers and Stream Health in the Mid-Atlantic Region; Commercial Remote Sensing Space Policy Civil Implementation Update; USGS Commercial Remote Sensing Data Contracts (CRSDC); and Commercial Remote Sensing Space Policy (CRSSP): Civil Near-Term Requirements Collection Update.

Applications of Digitized 3-D Position-Sensitive CdZnTe Spectrometers for National Security and Nuclear Nonproliferation

NASA Astrophysics Data System (ADS)

Streicher, Michael W.

A nuclear weapon detonation remains one of the gravest threats to the global community. Although the likelihood of a nuclear event remains small, the economic and political ramifications of an event are vast. The surest way to reduce the probability of an incident is to account for the special nuclear materials (SNM) which can be used to produce a nuclear weapon. Materials which can be used to manufacture a radiological dispersion device ("dirty bomb") must also be monitored. Rapidly-deployable, commercially-available, room-temperature imaging gamma-ray spectrometers are improving the ability of authorities to intelligently and quickly respond to threats. New electronics which digitally-sample the radiation-induced signals in CdZnTe detectors have expanded the capabilities of these sensors. This thesis explores national security applications where digital readout of CdZnTe detectors significantly enhances capabilities. Radioactive sources can be detected more quickly using digitally-sampled CdZnTe detector due to the improved energy resolution. The excellent energy resolution also improves the accuracy of measurements of uranium enrichment and allows users to measure plutonium grade. Small differences in the recorded gamma-ray energy spectrum can be used to estimate the effective atomic number and mass thickness of materials shielding SNM sources. Improved position resolution of gamma-ray interactions through digital readout allows high resolution gamma-ray images of SNM revealing information about the source configuration. CdZnTe sensors can detect the presence of neutrons, indirectly, through measurement of gamma rays released during capture of thermal neutrons by Cd-113 or inelastic scattering with any constituent nuclei. Fast neutrons, such as those released following fission, can be directly detected through elastic scattering interactions in the detector. Neutrons are a strong indicator of fissile material, and the background neutron rate is much lower than the gamma-ray background rate. Neutrons can more easily penetrate shielding materials as well which can greatly aid in the detection of shielded SNM. Digital CdZnTe readout enables the sensors to maintain excellent energy resolution at high count rates. Pulse pile-up and preamplifier decay can be monitored and corrected for on an event-by-event basis limiting energy resolution degradation in dose rates higher than 100 mR/hr. Finally, new iterations of the digital electronics have enhanced gamma-ray detection capabilities at high photon energies. Currently, gamma rays with energy up to 4.4 MeV have been detected. High-energy photon detection is critical for many proposed active interrogation systems.

Novel ophthalmological OCT instrument design

NASA Astrophysics Data System (ADS)

Xu, Xiaonan; Gao, Jiansong; Guo, Jihua; Xue, Ping

2002-04-01

This paper presents a novel ophthamological optical coherence tomography detecting instrument, which we design, and introduces measuring arm emphatically. For glaucoma which is very common in the Orient, this system can achieve both the eyeground detection and the canthus detection. And it combines the cranny lamp's conventional detection with optical coherence tomography. Considering all the system, this design has a longitudinal resolution of 15 um, and a transverse resolution of 20 um at imaging velocity of 4 frames per second.

High resolution climate projection of storm surge at the Venetian coast

NASA Astrophysics Data System (ADS)

Mel, R.; Sterl, A.; Lionello, P.

2013-04-01

Climate change impact on storm surge regime is of great importance for the safety and maintenance of Venice. In this study a future storm surge scenario is evaluated using new high resolution sea level pressure and wind data recently produced by EC-Earth, an Earth System Model based on the operational seasonal forecast system of the European Centre for Medium-Range Weather Forecasts (ECMWF). The study considers an ensemble of six 5 yr long simulations of the rcp45 scenario at 0.25° resolution and compares the 2094-2098 to the 2004-2008 period. EC-Earth sea level pressure and surface wind fields are used as input for a shallow water hydrodynamic model (HYPSE) which computes sea level and barotropic currents in the Adriatic Sea. Results show that a high resolution climate model is needed for producing realistic values of storm surge statistics and confirm previous studies in that they show little sensitivity of storm surge levels to climate change. However, some climate change signals are detected, such as increased persistence of high pressure conditions, an increased frequency of windless hour, and a decreased number of moderate windstorms.

A Review of Hybrid Fiber-Optic Distributed Simultaneous Vibration and Temperature Sensing Technology and Its Geophysical Applications

PubMed Central

2017-01-01

Distributed sensing systems can transform an optical fiber cable into an array of sensors, allowing users to detect and monitor multiple physical parameters such as temperature, vibration and strain with fine spatial and temporal resolution over a long distance. Fiber-optic distributed acoustic sensing (DAS) and distributed temperature sensing (DTS) systems have been developed for various applications with varied spatial resolution, and spectral and sensing range. Rayleigh scattering-based phase optical time domain reflectometry (OTDR) for vibration and Raman/Brillouin scattering-based OTDR for temperature and strain measurements have been developed over the past two decades. The key challenge has been to find a methodology that would enable the physical parameters to be determined at any point along the sensing fiber with high sensitivity and spatial resolution, yet within acceptable frequency range for dynamic vibration, and temperature detection. There are many applications, especially in geophysical and mining engineering where simultaneous measurements of vibration and temperature are essential. In this article, recent developments of different hybrid systems for simultaneous vibration, temperature and strain measurements are analyzed based on their operation principles and performance. Then, challenges and limitations of the systems are highlighted for geophysical applications. PMID:29104259

A Review of Hybrid Fiber-Optic Distributed Simultaneous Vibration and Temperature Sensing Technology and Its Geophysical Applications.

PubMed

Miah, Khalid; Potter, David K

2017-11-01

Distributed sensing systems can transform an optical fiber cable into an array of sensors, allowing users to detect and monitor multiple physical parameters such as temperature, vibration and strain with fine spatial and temporal resolution over a long distance. Fiber-optic distributed acoustic sensing (DAS) and distributed temperature sensing (DTS) systems have been developed for various applications with varied spatial resolution, and spectral and sensing range. Rayleigh scattering-based phase optical time domain reflectometry (OTDR) for vibration and Raman/Brillouin scattering-based OTDR for temperature and strain measurements have been developed over the past two decades. The key challenge has been to find a methodology that would enable the physical parameters to be determined at any point along the sensing fiber with high sensitivity and spatial resolution, yet within acceptable frequency range for dynamic vibration, and temperature detection. There are many applications, especially in geophysical and mining engineering where simultaneous measurements of vibration and temperature are essential. In this article, recent developments of different hybrid systems for simultaneous vibration, temperature and strain measurements are analyzed based on their operation principles and performance. Then, challenges and limitations of the systems are highlighted for geophysical applications.

The elusive character of discontinuous deep-water channels: New insights from Lucia Chica channel system, offshore California

USGS Publications Warehouse

Maier, K.L.; Fildani, A.; Paull, C.K.; Graham, S.A.; McHargue, T.R.; Caress, D.W.; McGann, M.

2011-01-01

New high-resolution autonomous underwater vehicle (AUV) seafloor images, with 1 m lateral resolution and 0.3 m vertical resolution, reveal unexpected seafloor rugosity and low-relief (<10 m), discontinuous conduits over ~70 km2. Continuous channel thalwegs were interpreted originally from lower-resolution images, but newly acquired AUV data indicate that a single sinuous channel fed a series of discontinuous lower-relief channels. These discontinuous channels were created by at least four avulsion events. Channel relief, defined as the height from the thalweg to the levee crest, controls avulsions and overall stratigraphic architecture of the depositional area. Flowstripped turbidity currents separated into and reactivated multiple channels to create a distributary pattern and developed discontinuous trains of cyclic scours and megaflutes, which may be erosional precursors to continuous channels. The diverse features now imaged in the Lucia Chica channel system (offshore California) are likely common in modern and ancient systems with similar overall morphologies, but have not been previously mapped with lower-resolution detection methods in any of these systems. ?? 2011 Geological Society of America.

Passive in-vehicle driver breath alcohol detection using advanced sensor signal acquisition and fusion.

PubMed

Ljungblad, Jonas; Hök, Bertil; Allalou, Amin; Pettersson, Håkan

2017-05-29

The research objective of the present investigation is to demonstrate the present status of passive in-vehicle driver breath alcohol detection and highlight the necessary conditions for large-scale implementation of such a system. Completely passive detection has remained a challenge mainly because of the requirements on signal resolution combined with the constraints of vehicle integration. The work is part of the Driver Alcohol Detection System for Safety (DADSS) program aiming at massive deployment of alcohol sensing systems that could potentially save thousands of American lives annually. The work reported here builds on earlier investigations, in which it has been shown that detection of alcohol vapor in the proximity of a human subject may be traced to that subject by means of simultaneous recording of carbon dioxide (CO 2 ) at the same location. Sensors based on infrared spectroscopy were developed to detect and quantify low concentrations of alcohol and CO 2 . In the present investigation, alcohol and CO 2 were recorded at various locations in a vehicle cabin while human subjects were performing normal in-step procedures and driving preparations. A video camera directed to the driver position was recording images of the driver's upper body parts, including the face, and the images were analyzed with respect to features of significance to the breathing behavior and breath detection, such as mouth opening and head direction. Improvement of the sensor system with respect to signal resolution including algorithm and software development, and fusion of the sensor and camera signals was successfully implemented and tested before starting the human study. In addition, experimental tests and simulations were performed with the purpose of connecting human subject data with repeatable experimental conditions. The results include occurrence statistics of detected breaths by signal peaks of CO 2 and alcohol. From the statistical data, the accuracy of breath alcohol estimation and timing related to initial driver routines (door opening, taking a seat, door closure, buckling up, etc.) can be estimated. The investigation confirmed the feasibility of passive driver breath alcohol detection using our present system. Trade-offs between timing and sensor signal resolution requirements will become critical. Further improvement of sensor resolution and system ruggedness is required before the results can be industrialized. It is concluded that a further important step toward completely passive detection of driver breath alcohol has been taken. If required, the sniffer function with alcohol detection capability can be combined with a subsequent highly accurate breath test to confirm the driver's legal status using the same sensor device. The study is relevant to crash avoidance, in particular driver monitoring systems and driver-vehicle interface design.

Standoff imaging of a masked human face using a 670 GHz high resolution radar

NASA Astrophysics Data System (ADS)

Kjellgren, Jan; Svedin, Jan; Cooper, Ken B.

2011-11-01

This paper presents an exploratory attempt to use high-resolution radar measurements for face identification in forensic applications. An imaging radar system developed by JPL was used to measure a human face at 670 GHz. Frontal views of the face were measured both with and without a ski mask at a range of 25 m. The realized spatial resolution was roughly 1 cm in all three dimensions. The surfaces of the ski mask and the face were detected by using the two dominating reflections from amplitude data. Various methods for visualization of these surfaces are presented. The possibility to use radar data to determine certain face distance measures between well-defined face landmarks, typically used for anthropometric statistics, was explored. The measures used here were face length, frontal breadth and interpupillary distance. In many cases the radar system seems to provide sufficient information to exclude an innocent subject from suspicion. For an accurate identification it is believed that a system must provide significantly more information.

Aircraft Detection in High-Resolution SAR Images Based on a Gradient Textural Saliency Map.

PubMed

Tan, Yihua; Li, Qingyun; Li, Yansheng; Tian, Jinwen

2015-09-11

This paper proposes a new automatic and adaptive aircraft target detection algorithm in high-resolution synthetic aperture radar (SAR) images of airport. The proposed method is based on gradient textural saliency map under the contextual cues of apron area. Firstly, the candidate regions with the possible existence of airport are detected from the apron area. Secondly, directional local gradient distribution detector is used to obtain a gradient textural saliency map in the favor of the candidate regions. In addition, the final targets will be detected by segmenting the saliency map using CFAR-type algorithm. The real high-resolution airborne SAR image data is used to verify the proposed algorithm. The results demonstrate that this algorithm can detect aircraft targets quickly and accurately, and decrease the false alarm rate.

Detection limits of intraoperative near infrared imaging for tumor resection.

PubMed

Thurber, Greg M; Figueiredo, Jose-Luiz; Weissleder, Ralph

2010-12-01

The application of fluorescent molecular imaging to surgical oncology is a developing field with the potential to reduce morbidity and mortality. However, the detection thresholds and other requirements for successful intervention remain poorly understood. Here we modeled and experimentally validated depth and size of detection of tumor deposits, trade-offs in coverage and resolution of areas of interest, and required pharmacokinetics of probes based on differing levels of tumor target presentation. Three orthotopic tumor models were imaged by widefield epifluorescence and confocal microscopes, and the experimental results were compared with pharmacokinetic models and light scattering simulations to determine detection thresholds. Widefield epifluorescence imaging can provide sufficient contrast to visualize tumor margins and detect tumor deposits 3-5  mm deep based on labeled monoclonal antibodies at low objective magnification. At higher magnification, surface tumor deposits at cellular resolution are detectable at TBR ratios achieved with highly expressed antigens. A widefield illumination system with the capability for macroscopic surveying and microscopic imaging provides the greatest utility for varying surgical goals. These results have implications for system and agent designs, which ultimately should aid complete resection in most surgical beds and provide real-time feedback to obtain clean margins. © 2010 Wiley-Liss, Inc.

Strategies and limitations for fluorescence detection of XAFS at high flux beamlines

DOE PAGES

Heald, Steve M.

2015-02-17

The issue of detecting the XAFS signal from dilute samples is discussed in detail with the aim of making best use of high flux beamlines that provide up to 10 13 photons -1. Various detection methods are compared, including filters with slits, solid state detectors, crystal analyzers and combinations of these. These comparisons rely on simulations that use experimentally determined parameters. It is found that inelastic scattering places a fundamental limit on detection, and that it is important to take proper account of the polarization dependence of the signals. The combination of a filter–slit system with a solid state detectormore » is a promising approach. With an optimized system good performance can be obtained even if the total count rate is limited to 10 7 Hz. Detection schemes with better energy resolution can help at the largest dilutions if their collection efficiency and count rate limits can be improved.« less

Strategies and limitations for fluorescence detection of XAFS at high flux beamlines

PubMed Central

Heald, Steve M.

2015-01-01

The issue of detecting the XAFS signal from dilute samples is discussed in detail with the aim of making best use of high flux beamlines that provide up to 1013 photons s−1. Various detection methods are compared, including filters with slits, solid state detectors, crystal analyzers and combinations of these. These comparisons rely on simulations that use experimentally determined parameters. It is found that inelastic scattering places a fundamental limit on detection, and that it is important to take proper account of the polarization dependence of the signals. The combination of a filter–slit system with a solid state detector is a promising approach. With an optimized system good performance can be obtained even if the total count rate is limited to 107 Hz. Detection schemes with better energy resolution can help at the largest dilutions if their collection efficiency and count rate limits can be improved. PMID:25723945

Fiber-Optic Magnetometry and Thermometry Using Optically Detected Magnetic Resonance With Nitrogen-Vacancy Centers in Diamond

NASA Astrophysics Data System (ADS)

Blakley, Sean Michael

Nitrogen--vacancy diamond (NVD) quantum sensors are an emerging technology that has shown great promise in areas like high-resolution thermometry and magnetometry. Optical fibers provide attractive new application paradigms for NVD technology. A detailed description of the fabrication processes associated with the development of novel fiber-optic NVD probes are presented in this work. The demonstrated probes are tested on paradigmatic model systems designed to ascertain their suitability for use in challenging biological environments. Methods employing optically detected magnetic resonance (ODMR) are used to accurately measure and map temperature distributions of small objects and to demonstrate emergent temperature-dependent phenomena in genetically modified living organisms. These methods are also used to create detailed high resolution spatial maps of both magnetic scalar and magnetic vector field distributions of spatially localized weak field features in the presence of a noisy, high-field background.

Compact CdZnTe-based gamma camera for prostate cancer imaging

NASA Astrophysics Data System (ADS)

Cui, Yonggang; Lall, Terry; Tsui, Benjamin; Yu, Jianhua; Mahler, George; Bolotnikov, Aleksey; Vaska, Paul; De Geronimo, Gianluigi; O'Connor, Paul; Meinken, George; Joyal, John; Barrett, John; Camarda, Giuseppe; Hossain, Anwar; Kim, Ki Hyun; Yang, Ge; Pomper, Marty; Cho, Steve; Weisman, Ken; Seo, Youngho; Babich, John; LaFrance, Norman; James, Ralph B.

2011-06-01

In this paper, we discuss the design of a compact gamma camera for high-resolution prostate cancer imaging using Cadmium Zinc Telluride (CdZnTe or CZT) radiation detectors. Prostate cancer is a common disease in men. Nowadays, a blood test measuring the level of prostate specific antigen (PSA) is widely used for screening for the disease in males over 50, followed by (ultrasound) imaging-guided biopsy. However, PSA tests have a high falsepositive rate and ultrasound-guided biopsy has a high likelihood of missing small cancerous tissues. Commercial methods of nuclear medical imaging, e.g. PET and SPECT, can functionally image the organs, and potentially find cancer tissues at early stages, but their applications in diagnosing prostate cancer has been limited by the smallness of the prostate gland and the long working distance between the organ and the detectors comprising these imaging systems. CZT is a semiconductor material with wide band-gap and relatively high electron mobility, and thus can operate at room temperature without additional cooling. CZT detectors are photon-electron direct-conversion devices, thus offering high energy-resolution in detecting gamma rays, enabling energy-resolved imaging, and reducing the background of Compton-scattering events. In addition, CZT material has high stopping power for gamma rays; for medical imaging, a few-mm-thick CZT material provides adequate detection efficiency for many SPECT radiotracers. Because of these advantages, CZT detectors are becoming popular for several SPECT medical-imaging applications. Most recently, we designed a compact gamma camera using CZT detectors coupled to an application-specific-integratedcircuit (ASIC). This camera functions as a trans-rectal probe to image the prostate gland from a distance of only 1-5 cm, thus offering higher detection efficiency and higher spatial resolution. Hence, it potentially can detect prostate cancers at their early stages. The performance tests of this camera have been completed. The results show better than 6-mm resolution at a distance of 1 cm. Details of the test results are discussed in this paper.

A novel high resolution, high sensitivity SPECT detector for molecular imaging of cardiovascular diseases

NASA Astrophysics Data System (ADS)

Cusanno, F.; Argentieri, A.; Baiocchi, M.; Colilli, S.; Cisbani, E.; De Vincentis, G.; Fratoni, R.; Garibaldi, F.; Giuliani, F.; Gricia, M.; Lucentini, M.; Magliozzi, M. L.; Majewski, S.; Marano, G.; Musico, P.; Musumeci, M.; Santavenere, F.; Torrioli, S.; Tsui, B. M. W.; Vitelli, L.; Wang, Y.

2010-05-01

Cardiovascular diseases are the most common cause of death in western countries. Understanding the rupture of vulnerable atherosclerotic plaques and monitoring the effect of innovative therapies of heart failure is of fundamental importance. A flexible, high resolution, high sensitivity detector system for molecular imaging with radionuclides on small animal models has been designed for this aim. A prototype has been built using tungsten pinhole and LaBr3(Ce) scintillator coupled to Hamamatsu Flat Panel PMTs. Compact individual-channel readout has been designed, built and tested. Measurements with phantoms as well as pilot studies on mice have been performed, the results show that the myocardial perfusion in mice can be determined with sufficient precision. The detector will be improved replacing the Hamamatsu Flat Panel with Silicon Photomultipliers (SiPMs) to allow integration of the system with MRI scanners. Application of LaBr3(Ce) scintillator coupled to photosensor with high photon detection efficiency and excellent energy resolution will allow dual-label imaging to monitor simultaneously the cardiac perfusion and the molecular targets under investigation during the heart therapy.

Rapid detection of Colorado potato beetle damage using small unmanned aircraft

USDA-ARS?s Scientific Manuscript database

Remote sensing with small unmanned aircraft systems (sUAS) has potential applications in agriculture because low flight altitudes allow image acquisition at very high spatial resolution. Damage to potato fields by the Colorado potato beetle (Leptinotarsa decemlineata) rapidly increases from initial...

Development of a combined microSPECT/CT system for small animal imaging

NASA Astrophysics Data System (ADS)

Sun, Mingshan

Modern advances in the biomedical sciences have placed increased attention on small animals such as mice and rats as models of human biology and disease in biological research and pharmaceutical development. Their small size and fast breeding rate, their physiologic similarity to human, and, more importantly, the availability of sophisticated genetic manipulations, all have made mice and rats the laboratory mammals of choice in these experimental studies. However, the increased use of small animals in biomedical research also calls for new instruments that can measure the anatomic and metabolic information noninvasively with adequate spatial resolution and measurement sensitivity to facilitate these studies. This dissertation describes the engineering development of a combined single photon emission computed tomography (SPECT) and X-ray computed tomography (CT) system dedicated for small animals imaging. The system aims to obtain both the anatomic and metabolic images with submillimeter spatial resolution in a way that the data can be correlated to provide improved image quality and to offer more complete biological evaluation for biomedical studies involving small animals. The project requires development of complete microSPECT and microCT subsystems. Both subsystems are configured with a shared gantry and animal bed with integrated instrumentation for data acquisition and system control. The microCT employs a microfocus X-ray tube and a CCD-based detector for low noise, high resolution imaging. The microSPECT utilizes three semiconductor detectors coupled with pinhole collimators. A significant contribution of this dissertation project is the development of iterative algorithms with geometrical compensation that allows radionuclide images to be reconstructed at submillimeter spatial resolution, but with significantly higher detection efficiency than conventional methods. Both subsystems are capable of helical scans, offering lengthened field of view and improved axial resolution. System performance of both modalities is characterized with phantoms and animals. The microSPECT shows 0.6 mm resolution and 60 cps/MBq detection efficiency for imaging mice with 0.5 mm pinholes. The microCT achieves 120 mum spatial resolution on detector but with a relatively low detective quantum efficiency of 0.2 at the zero frequency. The combined system demonstrates a flexible platform for instrumentation development and a valuable tool for biomedical research. In summary, this dissertation describes the development of a combined SPECT/CT system for imaging the physiological function and anatomical structure in small animals.

Extended depth of field imaging for high speed object analysis

NASA Technical Reports Server (NTRS)

Frost, Keith (Inventor); Ortyn, William (Inventor); Basiji, David (Inventor); Bauer, Richard (Inventor); Liang, Luchuan (Inventor); Hall, Brian (Inventor); Perry, David (Inventor)

2011-01-01

A high speed, high-resolution flow imaging system is modified to achieve extended depth of field imaging. An optical distortion element is introduced into the flow imaging system. Light from an object, such as a cell, is distorted by the distortion element, such that a point spread function (PSF) of the imaging system is invariant across an extended depth of field. The distorted light is spectrally dispersed, and the dispersed light is used to simultaneously generate a plurality of images. The images are detected, and image processing is used to enhance the detected images by compensating for the distortion, to achieve extended depth of field images of the object. The post image processing preferably involves de-convolution, and requires knowledge of the PSF of the imaging system, as modified by the optical distortion element.

Thermographic imaging for high-temperature composite materials: A defect detection study

NASA Technical Reports Server (NTRS)

Roth, Don J.; Bodis, James R.; Bishop, Chip

1995-01-01

The ability of a thermographic imaging technique for detecting flat-bottom hole defects of various diameters and depths was evaluated in four composite systems (two types of ceramic matrix composites, one metal matrix composite, and one polymer matrix composite) of interest as high-temperature structural materials. The holes ranged from 1 to 13 mm in diameter and 0.1 to 2.5 mm in depth in samples approximately 2-3 mm thick. The thermographic imaging system utilized a scanning mirror optical system and infrared (IR) focusing lens in conjunction with a mercury cadmium telluride infrared detector element to obtain high resolution infrared images. High intensity flash lamps located on the same side as the infrared camera were used to heat the samples. After heating, up to 30 images were sequentially acquired at 70-150 msec intervals. Limits of detectability based on depth and diameter of the flat-bottom holes were defined for each composite material. Ultrasonic and radiographic images of the samples were obtained and compared with the thermographic images.

Pole Photogrammetry with AN Action Camera for Fast and Accurate Surface Mapping

NASA Astrophysics Data System (ADS)

Gonçalves, J. A.; Moutinho, O. F.; Rodrigues, A. C.

2016-06-01

High resolution and high accuracy terrain mapping can provide height change detection for studies of erosion, subsidence or land slip. A UAV flying at a low altitude above the ground, with a compact camera, acquires images with resolution appropriate for these change detections. However, there may be situations where different approaches may be needed, either because higher resolution is required or the operation of a drone is not possible. Pole photogrammetry, where a camera is mounted on a pole, pointing to the ground, is an alternative. This paper describes a very simple system of this kind, created for topographic change detection, based on an action camera. These cameras have high quality and very flexible image capture. Although radial distortion is normally high, it can be treated in an auto-calibration process. The system is composed by a light aluminium pole, 4 meters long, with a 12 megapixel GoPro camera. Average ground sampling distance at the image centre is 2.3 mm. The user moves along a path, taking successive photos, with a time lapse of 0.5 or 1 second, and adjusting the speed in order to have an appropriate overlap, with enough redundancy for 3D coordinate extraction. Marked ground control points are surveyed with GNSS for precise georeferencing of the DSM and orthoimage that are created by structure from motion processing software. An average vertical accuracy of 1 cm could be achieved, which is enough for many applications, for example for soil erosion. The GNSS survey in RTK mode with permanent stations is now very fast (5 seconds per point), which results, together with the image collection, in a very fast field work. If an improved accuracy is needed, since image resolution is 1/4 cm, it can be achieved using a total station for the control point survey, although the field work time increases.

Automated detection of analyzable metaphase chromosome cells depicted on scanned digital microscopic images

NASA Astrophysics Data System (ADS)

Qiu, Yuchen; Wang, Xingwei; Chen, Xiaodong; Li, Yuhua; Liu, Hong; Li, Shibo; Zheng, Bin

2010-02-01

Visually searching for analyzable metaphase chromosome cells under microscopes is quite time-consuming and difficult. To improve detection efficiency, consistency, and diagnostic accuracy, an automated microscopic image scanning system was developed and tested to directly acquire digital images with sufficient spatial resolution for clinical diagnosis. A computer-aided detection (CAD) scheme was also developed and integrated into the image scanning system to search for and detect the regions of interest (ROI) that contain analyzable metaphase chromosome cells in the large volume of scanned images acquired from one specimen. Thus, the cytogeneticists only need to observe and interpret the limited number of ROIs. In this study, the high-resolution microscopic image scanning and CAD performance was investigated and evaluated using nine sets of images scanned from either bone marrow (three) or blood (six) specimens for diagnosis of leukemia. The automated CAD-selection results were compared with the visual selection. In the experiment, the cytogeneticists first visually searched for the analyzable metaphase chromosome cells from specimens under microscopes. The specimens were also automated scanned and followed by applying the CAD scheme to detect and save ROIs containing analyzable cells while deleting the others. The automated selected ROIs were then examined by a panel of three cytogeneticists. From the scanned images, CAD selected more analyzable cells than initially visual examinations of the cytogeneticists in both blood and bone marrow specimens. In general, CAD had higher performance in analyzing blood specimens. Even in three bone marrow specimens, CAD selected 50, 22, 9 ROIs, respectively. Except matching with the initially visual selection of 9, 7, and 5 analyzable cells in these three specimens, the cytogeneticists also selected 41, 15 and 4 new analyzable cells, which were missed in initially visual searching. This experiment showed the feasibility of applying this CAD-guided high-resolution microscopic image scanning system to prescreen and select ROIs that may contain analyzable metaphase chromosome cells. The success and the further improvement of this automated scanning system may have great impact on the future clinical practice in genetic laboratories to detect and diagnose diseases.

A habituation based approach for detection of visual changes in surveillance camera

NASA Astrophysics Data System (ADS)

Sha'abani, M. N. A. H.; Adan, N. F.; Sabani, M. S. M.; Abdullah, F.; Nadira, J. H. S.; Yasin, M. S. M.

2017-09-01

This paper investigates a habituation based approach in detecting visual changes using video surveillance systems in a passive environment. Various techniques have been introduced for dynamic environment such as motion detection, object classification and behaviour analysis. However, in a passive environment, most of the scenes recorded by the surveillance system are normal. Therefore, implementing a complex analysis all the time in the passive environment resulting on computationally expensive, especially when using a high video resolution. Thus, a mechanism of attention is required, where the system only responds to an abnormal event. This paper proposed a novelty detection mechanism in detecting visual changes and a habituation based approach to measure the level of novelty. The objective of the paper is to investigate the feasibility of the habituation based approach in detecting visual changes. Experiment results show that the approach are able to accurately detect the presence of novelty as deviations from the learned knowledge.

Ship detection from high-resolution imagery based on land masking and cloud filtering

NASA Astrophysics Data System (ADS)

Jin, Tianming; Zhang, Junping

2015-12-01

High resolution satellite images play an important role in target detection application presently. This article focuses on the ship target detection from the high resolution panchromatic images. Taking advantage of geographic information such as the coastline vector data provided by NOAA Medium Resolution Coastline program, the land region is masked which is a main noise source in ship detection process. After that, the algorithm tries to deal with the cloud noise which appears frequently in the ocean satellite images, which is another reason for false alarm. Based on the analysis of cloud noise's feature in frequency domain, we introduce a windowed noise filter to get rid of the cloud noise. With the help of morphological processing algorithms adapted to target detection, we are able to acquire ship targets in fine shapes. In addition, we display the extracted information such as length and width of ship targets in a user-friendly way i.e. a KML file interpreted by Google Earth.

High resolution multiple excitation spot optical microscopy

NASA Astrophysics Data System (ADS)

Dilipkumar, Shilpa; Mondal, Partha Pratim

2011-06-01

We propose fundamental improvements in three-dimensional (3D) resolution of multiple excitation spot optical microscopy. The excitation point spread function (PSF) is generated by two interfering counter-propagating depth-of-focus beams along the optical axis. Detection PSF is obtained by coherently interfering the emitted fluorescent light (collected by both the objectives) at the detector. System PSF shows upto 14-fold reduction in focal volume as compared to confocal, and almost 2-fold improvement in lateral resolution. Proposed PSF has the ability to simultaneously excite multiple 3D-spots of sub-femtoliter volume. Potential applications are in fluorescence microscopy and nanobioimaging.

Direct measurement of mammographic X-ray spectra with a digital CdTe detection system.

PubMed

Abbene, Leonardo; Gerardi, Gaetano; Principato, Fabio; Del Sordo, Stefano; Raso, Giuseppe

2012-01-01

In this work we present a detection system, based on a CdTe detector and an innovative digital pulse processing (DPP) system, for high-rate X-ray spectroscopy in mammography (1-30 keV). The DPP system performs a height and shape analysis of the detector pulses, sampled and digitized by a 14-bit, 100 MHz ADC. We show the results of the characterization of the detection system both at low and high photon counting rates by using monoenergetic X-ray sources and a nonclinical X-ray tube. The detection system exhibits excellent performance up to 830 kcps with an energy resolution of 4.5% FWHM at 22.1 keV. Direct measurements of clinical molybdenum X-ray spectra were carried out by using a pinhole collimator and a custom alignment device. A comparison with the attenuation curves and the half value layer values, obtained from the measured and simulated spectra, from an ionization chamber and from a solid state dosimeter, also shows the accuracy of the measurements. These results make the proposed detection system a very attractive tool for both laboratory research, calibration of dosimeters and advanced quality controls in mammography.

Optimizing 1-μs-Resolution Single-Molecule Force Spectroscopy on a Commercial Atomic Force Microscope.

PubMed

Edwards, Devin T; Faulk, Jaevyn K; Sanders, Aric W; Bull, Matthew S; Walder, Robert; LeBlanc, Marc-Andre; Sousa, Marcelo C; Perkins, Thomas T

2015-10-14

Atomic force microscopy (AFM)-based single-molecule force spectroscopy (SMFS) is widely used to mechanically measure the folding and unfolding of proteins. However, the temporal resolution of a standard commercial cantilever is 50-1000 μs, masking rapid transitions and short-lived intermediates. Recently, SMFS with 0.7-μs temporal resolution was achieved using an ultrashort (L = 9 μm) cantilever on a custom-built, high-speed AFM. By micromachining such cantilevers with a focused ion beam, we optimized them for SMFS rather than tapping-mode imaging. To enhance usability and throughput, we detected the modified cantilevers on a commercial AFM retrofitted with a detection laser system featuring a 3-μm circular spot size. Moreover, individual cantilevers were reused over multiple days. The improved capabilities of the modified cantilevers for SMFS were showcased by unfolding a polyprotein, a popular biophysical assay. Specifically, these cantilevers maintained a 1-μs response time while eliminating cantilever ringing (Q ≅ 0.5). We therefore expect such cantilevers, along with the instrumentational improvements to detect them on a commercial AFM, to accelerate high-precision AFM-based SMFS studies.

Imaging pancreatobiliary ductal system with optical coherence tomography: A review

PubMed Central

Mahmud, Mohammad S; May, Gray R; Kamal, Mohammad M; Khwaja, Ahmed S; Sun, Carry; Vitkin, Alex; Yang, Victor XD

2013-01-01

An accurate, noninvasive and cost-effective method of in situ tissue evaluation during endoscopy would be highly advantageous for the detection of dysplasia or early cancer and for identifying different disease stages. Optical coherence tomography (OCT) is a noninvasive, high-resolution (1-10 μm) emerging optical imaging method with potential for identifying microscopic subsurface features in the pancreatic and biliary ductal system. Tissue microstructure of pancreaticobiliary ductal system has been successfully imaged by inserting an OCT probe through a standard endoscope operative channel. High-resolution OCT images and the technique’s endoscopic compatibility have allowed for the microstructural diagnostic of the pancreatobiliary diseases. In this review, we discussed currently available pancreaticobiliary ductal imaging systems to assess the pancreatobiliary tissue microstructure and to evaluate varieties of pancreaticobiliary disorders and diseases. Results show that OCT can improve the quality of images of pancreatobiliary system during endoscopic retrograde cholangiopancheatography procedure, which may be important in distinguishing between the neoplastic and non-neoplastic lesions. PMID:24255746

Fibre Optic Mechanical Sensors For Aerospace Applications

NASA Astrophysics Data System (ADS)

Batchellor, C. R.; Dakin, J. P.; Pearce, D. A. J.

1989-04-01

A fiber optic multisensor methane detection system matched to topology and environment of a coal mine is reported. The system involves time domain multiplexed (TDM) methane sensors based on selective absorption of source radiation by atomic or molecular species in the gas sensing heads. A two-wavelength ratiometric approach allows simple self referencing, cancels out errors arising from other contaminants, and improves the measurement contrast. The laboratory system consists of a high radiance LED source, multimode fiber, optical sensing head, optical bandpass filters, and involves synchronous detection with low noise photodiodes and a lock-in amplifier. Detection sensitivity upon spectral resolution of the optical filters has also been investigated and described. The system performance was evaluated and the results are presented.

Procedures for the interpretation and use of elevation scanning laser/multi-sensor data for short range hazard detection and avoidance for an autonomous planetary rover

NASA Technical Reports Server (NTRS)

Troiani, N.; Yerazunis, S. W.

1978-01-01

An autonomous roving science vehicle that relies on terrain data acquired by a hierarchy of sensors for navigation was one method of carrying out such a mission. The hierarchy of sensors included a short range sensor with sufficient resolution to detect every possible obstacle and with the ability to make fast and reliable terrain characterizations. A multilaser, multidetector triangulation system was proposed as a short range sensor. The general system was studied to determine its perception capabilities and limitations. A specific rover and low resolution sensor system was then considered. After studying the data obtained, a hazard detection algorithm was developed that accounts for all possible terrains given the sensor resolution. Computer simulation of the rover on various terrains was used to test the entire hazard detection system.

A new spectroscopic imager for X-rays from 0.5 keV to 150 keV combining a pnCCD and a columnar CsI(Tl) scintillator

NASA Astrophysics Data System (ADS)

Schlosser, D. M.; Hartmann, R.; Kalok, D.; Bechteler, A.; Abboud, A.; Shokr, M.; Çonka, T.; Pietsch, U.; Strüder, L.

2017-04-01

By combining a low noise fully depleted pnCCD detector with a columnar CsI(Tl) scintillator an energy dispersive spatial resolving detector can be realized with a high quantum efficiency in the range from below 0.5 keV to above 150 keV. The used scintillator system increases the pulse height of gamma-rays converted in the CsI(Tl), due to focusing properties of the columnar scintillator structure by reducing the event size in indirect detection mode (conversion in the scintillator). In case of direct detection (conversion in the silicon of the pnCCD) the relative energy resolution is 0.7% at 122 keV (FWHM = 850 eV) and the spatial resolution is less than 75 μm. In case of indirect detection the relative energy resolution, integrated over all event sizes is about 9% at 122 keV with an expected spatial precision of below 75 μm.

A Keplerian Disk around Orion SrCI, a ∼ 15 M ⊙ YSO

NASA Astrophysics Data System (ADS)

Ginsburg, Adam; Bally, John; Goddi, Ciriaco; Plambeck, Richard; Wright, Melvyn

2018-06-01

We report ALMA long-baseline observations of Orion Source I (SrcI), with a resolution 0.″03–0.″06 (12–24 au) at 1.3 and 3.2 mm. We detect both continuum and spectral line emission from SrcI’s disk. We also detect a central weakly resolved source that we interpret as a hot spot in the inner disk, which may indicate the presence of a binary system. The high angular resolution and sensitivity of these observations allows us to measure the outer envelope of the rotation curve of the H2O {5}5,0}{--}{6}4,3} line, which gives a mass M I ≈ 15 ± 2 {M}ȯ . We detected several other lines that more closely trace the disk, but were unable to identify their parent species. Using centroid-of-channel methods on these other lines, we infer a similar mass. These measurements solidify SrcI as a genuine high-mass protostar system and support the theory that SrcI and the Becklin-Neugebauer Object were ejected from the dynamical decay of a multiple-star system ∼500 years ago, an event that also launched the explosive molecular outflow in Orion.

Detection of 3-methylmethcathinone and its metabolites 3-methylephedrine and 3-methylnorephedrine in pubic hair samples by liquid chromatography-high resolution/high accuracy Orbitrap mass spectrometry.

PubMed

Frison, Giampietro; Frasson, Samuela; Zancanaro, Flavio; Tedeschi, Gianpaola; Zamengo, Luca

2016-08-01

Hair testing is considered to be one of the most efficient tool to investigate drug-related histories, particularly when the period of use needs to be tested back to many days or even months before sampling. High-resolution mass spectrometry represents today one of the most specific and sensitive analytical techniques to detect psychoactive substances in hair samples following single or multiple drug exposures. In this study pubic hair testing, by means of liquid chromatography-high resolution/high accuracy Orbitrap mass spectrometry, was employed to document the potential intake of five new psychoactive substances by a drug dealer. Pubic hair samples were decontaminated and pulverized with a ball mill, and, after the addition of the internal standard 3,4-methylenedioxypropylamphetamine, extracted with methanol:trifluoroacetic acid 9:1 at 45°C for one night. The obtained extracts were analyzed on a Thermo Fisher Scientific Accela 1250 liquid chromatography system coupled to a Thermo Fisher Scientific single-stage Exactive HCD mass spectrometry system. 3-methylmethcathinone (3-MMC) was found to be present at a concentration of 25.8ng/mg in the pubic hair sample, whereas the other four designer drugs were found to be absent. 3-methylephedrines and 3-methylnorephedrines, metabolites of 3-MMC, were identified in the same sample, thereby proving the 3-MMC intake by the drug dealer. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Malaria Diagnosis Using a Mobile Phone Polarized Microscope

NASA Astrophysics Data System (ADS)

Pirnstill, Casey W.; Coté, Gerard L.

2015-08-01

Malaria remains a major global health burden, and new methods for low-cost, high-sensitivity, diagnosis are essential, particularly in remote areas with low-resource around the world. In this paper, a cost effective, optical cell-phone based transmission polarized light microscope system is presented for imaging the malaria pigment known as hemozoin. It can be difficult to determine the presence of the pigment from background and other artifacts, even for skilled microscopy technicians. The pigment is much easier to observe using polarized light microscopy. However, implementation of polarized light microscopy lacks widespread adoption because the existing commercial devices have complicated designs, require sophisticated maintenance, tend to be bulky, can be expensive, and would require re-training for existing microscopy technicians. To this end, a high fidelity and high optical resolution cell-phone based polarized light microscopy system is presented which is comparable to larger bench-top polarized microscopy systems but at much lower cost and complexity. The detection of malaria in fixed and stained blood smears is presented using both, a conventional polarized microscope and our cell-phone based system. The cell-phone based polarimetric microscopy design shows the potential to have both the resolution and specificity to detect malaria in a low-cost, easy-to-use, modular platform.

Malaria Diagnosis Using a Mobile Phone Polarized Microscope

PubMed Central

Pirnstill, Casey W.; Coté, Gerard L.

2015-01-01

Malaria remains a major global health burden, and new methods for low-cost, high-sensitivity, diagnosis are essential, particularly in remote areas with low-resource around the world. In this paper, a cost effective, optical cell-phone based transmission polarized light microscope system is presented for imaging the malaria pigment known as hemozoin. It can be difficult to determine the presence of the pigment from background and other artifacts, even for skilled microscopy technicians. The pigment is much easier to observe using polarized light microscopy. However, implementation of polarized light microscopy lacks widespread adoption because the existing commercial devices have complicated designs, require sophisticated maintenance, tend to be bulky, can be expensive, and would require re-training for existing microscopy technicians. To this end, a high fidelity and high optical resolution cell-phone based polarized light microscopy system is presented which is comparable to larger bench-top polarized microscopy systems but at much lower cost and complexity. The detection of malaria in fixed and stained blood smears is presented using both, a conventional polarized microscope and our cell-phone based system. The cell-phone based polarimetric microscopy design shows the potential to have both the resolution and specificity to detect malaria in a low-cost, easy-to-use, modular platform. PMID:26303238

Integration of High-Resolution Laser Displacement Sensors and 3D Printing for Structural Health Monitoring

PubMed Central

Chang, Shu-Wei; Kuo, Shih-Yu; Huang, Ting-Hsuan

2017-01-01

This paper presents a novel experimental design for complex structural health monitoring (SHM) studies achieved by integrating 3D printing technologies, high-resolution laser displacement sensors, and multiscale entropy SHM theory. A seven-story structure with a variety of composite bracing systems was constructed using a dual-material 3D printer. A wireless Bluetooth vibration speaker was used to excite the ground floor of the structure, and high-resolution laser displacement sensors (1-μm resolution) were used to monitor the displacement history on different floors. Our results showed that the multiscale entropy SHM method could detect damage on the 3D-printed structures. The results of this study demonstrate that integrating 3D printing technologies and high-resolution laser displacement sensors enables the design of cheap, fast processing, complex, small-scale civil structures for future SHM studies. The novel experimental design proposed in this study provides a suitable platform for investigating the validity and sensitivity of SHM in different composite structures and damage conditions for real life applications in the future. PMID:29271937

Integration of High-Resolution Laser Displacement Sensors and 3D Printing for Structural Health Monitoring.

PubMed

Chang, Shu-Wei; Lin, Tzu-Kang; Kuo, Shih-Yu; Huang, Ting-Hsuan

2017-12-22

This paper presents a novel experimental design for complex structural health monitoring (SHM) studies achieved by integrating 3D printing technologies, high-resolution laser displacement sensors, and multiscale entropy SHM theory. A seven-story structure with a variety of composite bracing systems was constructed using a dual-material 3D printer. A wireless Bluetooth vibration speaker was used to excite the ground floor of the structure, and high-resolution laser displacement sensors (1-μm resolution) were used to monitor the displacement history on different floors. Our results showed that the multiscale entropy SHM method could detect damage on the 3D-printed structures. The results of this study demonstrate that integrating 3D printing technologies and high-resolution laser displacement sensors enables the design of cheap, fast processing, complex, small-scale civil structures for future SHM studies. The novel experimental design proposed in this study provides a suitable platform for investigating the validity and sensitivity of SHM in different composite structures and damage conditions for real life applications in the future.

Optimized 14 + 1 receive coil array and position system for 3D high-resolution MRI of dental and maxillomandibular structures.

PubMed

Sedlacik, Jan; Kutzner, Daniel; Khokale, Arun; Schulze, Dirk; Fiehler, Jens; Celik, Turgay; Gareis, Daniel; Smeets, Ralf; Friedrich, Reinhard E; Heiland, Max; Assaf, Alexandre T

2016-01-01

The purpose of this study was to design, build and test a multielement receive coil array and position system, which is optimized for three-dimensional (3D) high-resolution dental and maxillomandibular MRI with high patient comfort. A 14 + 1 coil array and positioning system, allowing easy handling by the technologists, reproducible positioning of the patients and high patient comfort, was tested with three healthy volunteers using a 3.0-T MRI machine (Siemens Skyra; Siemens Medical Solutions, Erlangen, Germany). High-resolution 3D T1 weighted, water excitation T1 weighted and fat-saturated T2 weighted imaging sequences were scanned, and 3D image data were reformatted in different orientations and curvatures to aid diagnosis. The high number of receiving coils and the comfortable positioning of the coil array close to the patient's face provided a high signal-to-noise ratio and allowed high quality, high resolution, 3D image data to be acquired within reasonable scan times owing to the possibility of parallel image acquisition acceleration. Reformatting the isotropic 3D image data in different views is helpful for diagnosis, e.g. panoramic reconstruction. The visibility of soft tissues such as the mandibular canal, nutritive canals and periodontal ligaments was exquisite. The optimized MRI receive coil array and positioning system for dental and oral-maxillofacial imaging provides a valuable tool for detecting and diagnosing pathologies in dental and oral-maxillofacial structures while avoiding radiation dose. The high patient comfort, as achieved by our design, is very crucial, since image artefacts due to movement or failing to complete the examination jeopardize the diagnostic value of MRI examinations.

Pulse-compression ghost imaging lidar via coherent detection.

PubMed

Deng, Chenjin; Gong, Wenlin; Han, Shensheng

2016-11-14

Ghost imaging (GI) lidar, as a novel remote sensing technique, has been receiving increasing interest in recent years. By combining pulse-compression technique and coherent detection with GI, we propose a new lidar system called pulse-compression GI lidar. Our analytical results, which are backed up by numerical simulations, demonstrate that pulse-compression GI lidar can obtain the target's spatial intensity distribution, range and moving velocity. Compared with conventional pulsed GI lidar system, pulse-compression GI lidar, without decreasing the range resolution, is easy to obtain high single pulse energy with the use of a long pulse, and the mechanism of coherent detection can eliminate the influence of the stray light, which is helpful to improve the detection sensitivity and detection range.

Investigation of the limitations of the highly pixilated CdZnTe detector for PET applications

PubMed Central

Komarov, Sergey; Yin, Yongzhi; Wu, Heyu; Wen, Jie; Krawczynski, Henric; Meng, Ling-Jian; Tai, Yuan-Chuan

2016-01-01

We are investigating the feasibility of a high resolution positron emission tomography (PET) insert device based on the CdZnTe detector with 350 μm anode pixel pitch to be integrated into a conventional animal PET scanner to improve its image resolution. In this paper, we have used a simplified version of the multi pixel CdZnTe planar detector, 5 mm thick with 9 anode pixels only. This simplified 9 anode pixel structure makes it possible to carry out experiments without a complete application-specific integrated circuits readout system that is still under development. Special attention was paid to the double pixel (or charge sharing) detections. The following characteristics were obtained in experiment: energy resolution full-width-at-half-maximum (FWHM) is 7% for single pixel and 9% for double pixel photoelectric detections of 511 keV gammas; timing resolution (FWHM) from the anode signals is 30 ns for single pixel and 35 ns for double pixel detections (for photoelectric interactions only the corresponding values are 20 and 25 ns); position resolution is 350 μm in x,y-plane and ~0.4 mm in depth-of-interaction. The experimental measurements were accompanied by Monte Carlo (MC) simulations to find a limitation imposed by spatial charge distribution. Results from MC simulations suggest the limitation of the intrinsic spatial resolution of the CdZnTe detector for 511 keV photoelectric interactions is 170 μm. The interpixel interpolation cannot recover the resolution beyond the limit mentioned above for photoelectric interactions. However, it is possible to achieve higher spatial resolution using interpolation for Compton scattered events. Energy and timing resolution of the proposed 350 μm anode pixel pitch detector is no better than 0.6% FWHM at 511 keV, and 2 ns FWHM, respectively. These MC results should be used as a guide to understand the performance limits of the pixelated CdZnTe detector due to the underlying detection processes, with the understanding of the inherent limitations of MC methods. PMID:23079763

Investigation of the limitations of the highly pixilated CdZnTe detector for PET applications.

PubMed

Komarov, Sergey; Yin, Yongzhi; Wu, Heyu; Wen, Jie; Krawczynski, Henric; Meng, Ling-Jian; Tai, Yuan-Chuan

2012-11-21

We are investigating the feasibility of a high resolution positron emission tomography (PET) insert device based on the CdZnTe detector with 350 µm anode pixel pitch to be integrated into a conventional animal PET scanner to improve its image resolution. In this paper, we have used a simplified version of the multi pixel CdZnTe planar detector, 5 mm thick with 9 anode pixels only. This simplified 9 anode pixel structure makes it possible to carry out experiments without a complete application-specific integrated circuits readout system that is still under development. Special attention was paid to the double pixel (or charge sharing) detections. The following characteristics were obtained in experiment: energy resolution full-width-at-half-maximum (FWHM) is 7% for single pixel and 9% for double pixel photoelectric detections of 511 keV gammas; timing resolution (FWHM) from the anode signals is 30 ns for single pixel and 35 ns for double pixel detections (for photoelectric interactions only the corresponding values are 20 and 25 ns); position resolution is 350 µm in x,y-plane and ∼0.4 mm in depth-of-interaction. The experimental measurements were accompanied by Monte Carlo (MC) simulations to find a limitation imposed by spatial charge distribution. Results from MC simulations suggest the limitation of the intrinsic spatial resolution of the CdZnTe detector for 511 keV photoelectric interactions is 170 µm. The interpixel interpolation cannot recover the resolution beyond the limit mentioned above for photoelectric interactions. However, it is possible to achieve higher spatial resolution using interpolation for Compton scattered events. Energy and timing resolution of the proposed 350 µm anode pixel pitch detector is no better than 0.6% FWHM at 511 keV, and 2 ns FWHM, respectively. These MC results should be used as a guide to understand the performance limits of the pixelated CdZnTe detector due to the underlying detection processes, with the understanding of the inherent limitations of MC methods.

Development of bimolecular fluorescence complementation using rsEGFP2 for detection and super-resolution imaging of protein-protein interactions in live cells

PubMed Central

Wang, Sheng; Ding, Miao; Chen, Xuanze; Chang, Lei; Sun, Yujie

2017-01-01

Direct visualization of protein-protein interactions (PPIs) at high spatial and temporal resolution in live cells is crucial for understanding the intricate and dynamic behaviors of signaling protein complexes. Recently, bimolecular fluorescence complementation (BiFC) assays have been combined with super-resolution imaging techniques including PALM and SOFI to visualize PPIs at the nanometer spatial resolution. RESOLFT nanoscopy has been proven as a powerful live-cell super-resolution imaging technique. With regard to the detection and visualization of PPIs in live cells with high temporal and spatial resolution, here we developed a BiFC assay using split rsEGFP2, a highly photostable and reversibly photoswitchable fluorescent protein previously developed for RESOLFT nanoscopy. Combined with parallelized RESOLFT microscopy, we demonstrated the high spatiotemporal resolving capability of a rsEGFP2-based BiFC assay by detecting and visualizing specifically the heterodimerization interactions between Bcl-xL and Bak as well as the dynamics of the complex on mitochondria membrane in live cells. PMID:28663931

a Brief Climatology of Cirrus LIDAR Ratios Measured by High Spectral Resolution LIDAR

NASA Astrophysics Data System (ADS)

Kuehn, R.; Holz, R.; Hair, J. W.; Vaughan, M. A.; Eloranta, E. W.

2015-12-01

Our ability to detect and probe the vertical extent of cirrus was hugely improved with the launch of the NASA-CNES CALIPSO mission in April 2006. However, our skill at retrieving the optical properties of the cirrus detected by the CALIPSO lidar is not yet commensurate with our detection abilities. As with any new observing system, CALIPSO faces challenges and uncertainties in the retrieval of the geophysical parameters from its fundamental measurements. Specifically, extinction and optical depth retrievals for elastic backscatter lidars like CALIPSO typically rely on a priori assumptions about layer-mean extinction-to-backscatter ratios (AKA lidar ratios), which can vary regionally and for which uncertainties are high. To improve CALIPSO optical properties retrievals, we show High Spectral Resolution Lidar (HSRL) measurements acquired with systems from the University of Wisconsin and NASA Langley. HSRLs can directly determine ice cloud extinction and lidar ratio by separately measuring the molecular and particulate components of the total backscattered signal, thus largely eliminating many of the uncertainties inherent in elastic backscatter retrievals. These measurements were acquired during the SEAC4RS (Huntsville, AL, USA and Singapore), and FRAPPE/DISCOVER-AQ 2014 (BAO tower near Boulder, CO, USA) field campaigns, and an intensive operations period in Hampton, VA, USA.

Inverse synthetic aperture radar imagery of a man with a rocket propelled grenade launcher

NASA Astrophysics Data System (ADS)

Tran, Chi N.; Innocenti, Roberto; Kirose, Getachew; Ranney, Kenneth I.; Smith, Gregory

2004-08-01

As the Army moves toward more lightly armored Future Combat System (FCS) vehicles, enemy personnel will present an increasing threat to U.S. soldiers. In particular, they face a very real threat from adversaries using shoulder-launched, rocket propelled grenade (RPG). The Army Research Laboratory has utilized its Aberdeen Proving Ground (APG) turntable facility to collect very high resolution, fully polarimetric Ka band radar data at low depression angles of a man holding an RPG. In this paper, we examine the resulting low resolution and high resolution range profiles; and based on the observed radar cross section (RCS) value, we attempt to determine the utility of Ka band radar for detecting enemy personnel carrying RPG launchers.

Research on airborne infrared leakage detection of natural gas pipeline

NASA Astrophysics Data System (ADS)

Tan, Dongjie; Xu, Bin; Xu, Xu; Wang, Hongchao; Yu, Dongliang; Tian, Shengjie

2011-12-01

An airborne laser remote sensing technology is proposed to detect natural gas pipeline leakage in helicopter which carrying a detector, and the detector can detect a high spatial resolution of trace of methane on the ground. The principle of the airborne laser remote sensing system is based on tunable diode laser absorption spectroscopy (TDLAS). The system consists of an optical unit containing the laser, camera, helicopter mount, electronic unit with DGPS antenna, a notebook computer and a pilot monitor. And the system is mounted on a helicopter. The principle and the architecture of the airborne laser remote sensing system are presented. Field test experiments are carried out on West-East Natural Gas Pipeline of China, and the results show that airborne detection method is suitable for detecting gas leak of pipeline on plain, desert, hills but unfit for the area with large altitude diversification.

Performance of europium-doped strontium iodide, transparent ceramics and bismuth-loaded polymer scintillators

NASA Astrophysics Data System (ADS)

Cherepy, N. J.; Payne, S. A.; Sturm, B. W.; O'Neal, S. P.; Seeley, Z. M.; Drury, O. B.; Haselhorst, L. K.; Rupert, B. L.; Sanner, R. D.; Thelin, P. A.; Fisher, S. E.; Hawrami, R.; Shah, K. S.; Burger, A.; Ramey, J. O.; Boatner, L. A.

2011-09-01

Recently discovered scintillators for gamma ray spectroscopy - single-crystal SrI2(Eu), GYGAG(Ce) transparent ceramic and Bismuth-loaded plastics - offer resolution and fabrication advantages compared to commercial scintillators, such as NaI(Tl) and standard PVT plastic. Energy resolution at 662 keV of 2.7% is obtained with SrI2(Eu), while 4.5% is obtained with GYGAG(Ce). A new transparent ceramic scintillator for radiographic imaging systems, GLO(Eu), offers high light yield of 70,000 Photons/MeV, high stopping, and low radiation damage. Implementation of single-crystal SrI2(Eu), Gd-based transparent ceramics, and Bi-loaded plastic scintillators can advance the state-of-the art in ionizing radiation detection systems.

Performance of Europium-Doped Strontium Iodide, Transparent Ceramics and Bismuth-loaded Polymer Scintillators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cherepy, N J; Payne, S A; Sturm, B W

2011-08-30

Recently discovered scintillators for gamma ray spectroscopy, single crystal SrI{sub 2}(Eu), GYGAG(Ce) transparent ceramic and Bismuth-loaded plastics, offer resolution and fabrication advantages compared to commercial scintillators, such as NaI(Tl) and standard PVT plastic. Energy resolution at 662 keV of 2.7% is obtained with SrI{sub 2}(Eu), while 4.5% is obtained with GYGAG(Ce). A new transparent ceramic scintillator for radiographic imaging systems, GLO(Eu) offers high light yield of 70,000 Photons/MeV, high stopping, and low radiation damage. Implementation of single crystal SrI{sub 2}(Eu), Gd-based transparent ceramics, and Bi-loaded plastic scintillators can advance the state-of-the art in ionizing radiation detection systems.

The Advanced Gamma-ray Imaging System (AGIS): Extragalactic Science

NASA Astrophysics Data System (ADS)

Coppi, Paolo S.; Extragalactic Science Working Group; AGIS Collaboration

2010-03-01

The Advanced Gamma-ray Imaging System (AGIS), a proposed next-generation array of Cherenkov telescopes, will provide an unprecedented view of the high energy universe. We discuss how AGIS, with its larger effective area, improved angular resolution, lower threshold, and an order of magnitude increase in sensitivity, impacts the extragalactic science possible in the very high energy domain. Likely source classes detectable by AGIS include AGN, GRBs, clusters, star-forming galaxies, and possibly the cascade radiation surrounding powerful cosmic accelerators. AGIS should see many of the sources discovered by Fermi. With its better sensitivity and angular resolution, AGIS then becomes a key instrument for identifying and characterizing Fermi survey sources, the majority of which will have limited Fermi photon statistics and localizations.

Studying Spatial Resolution of CZT Detectors Using Sub-Pixel Positioning for SPECT

NASA Astrophysics Data System (ADS)

Montémont, Guillaume; Lux, Silvère; Monnet, Olivier; Stanchina, Sylvain; Verger, Loïck

2014-10-01

CZT detectors are the basic building block of a variety of new SPECT systems. Their modularity allows adapting system architecture to specific applications such as cardiac, breast, brain or small animal imaging. In semiconductors, a high number of electron-hole pairs is produced by a single interaction. This direct conversion process allows better energy and spatial resolutions than usual scintillation detectors based on NaI(Tl). However, it remains often unclear if SPECT imaging can really benefit of that performance gain. We investigate the system performance of a detection module, which is based on 5 mm thick CZT with a segmented anode having a 2.5 mm pitch by simulation and experimentation. This pitch allows an easy assembly of the crystal on the readout board and limits the space occupied by electronics without significantly degrading energy and spatial resolution.

High resolution monitoring system for IRE stack releases.

PubMed

Deconninck, B; De Lellis, C

2013-11-01

The main activity of IRE (Institute for Radio-Element) is radioisotope production of bulk (99)Mo and (131)I for medical application (diagnosis and therapy). Those isotopes are chemically extracted from HEU (High Enriched Uranium) targets activated in reactors. During this process, fission products are released from the targets, including noble gases isotopes (Xe and Kr). Like any nuclear plant, IRE has release limits which are given by the Belgium authority and moreover IRE is in the process of continuously reducing the level of its releases. To achieve this mission, the need of an accurate tool is necessary and IRE has developed a specific monitoring system using a high resolution detector in order to identify and accurately estimate its gaseous releases. This system has a continuous air sampling system in the plant main stack. The sampled gases cross charcoal cartridges where they are slowed down and concentrated for higher detection efficiency. In front of those cartridges is installed an HPGe detector with a detection chain connected to a specific analysis system allowing on-line spectrum analysis. Each isotope can be separately followed without interferences, especially during the production process where high activity can be released. Due to its conception, the system also allows to measure iodine isotopes by integration on the charcoal cartridges. This device is of great help for accurately estimate IRE releases and to help for understanding specific releases and their origin in the production or maintenance process. Copyright © 2013 Elsevier Ltd. All rights reserved.

Testing the quality of images for permanent magnet desktop MRI systems using specially designed phantoms.

PubMed

Qiu, Jianfeng; Wang, Guozhu; Min, Jiao; Wang, Xiaoyan; Wang, Pengcheng

2013-12-21

Our aim was to measure the performance of desktop magnetic resonance imaging (MRI) systems using specially designed phantoms, by testing imaging parameters and analysing the imaging quality. We designed multifunction phantoms with diameters of 18 and 60 mm for desktop MRI scanners in accordance with the American Association of Physicists in Medicine (AAPM) report no. 28. We scanned the phantoms with three permanent magnet 0.5 T desktop MRI systems, measured the MRI image parameters, and analysed imaging quality by comparing the data with the AAPM criteria and Chinese national standards. Image parameters included: resonance frequency, high contrast spatial resolution, low contrast object detectability, slice thickness, geometrical distortion, signal-to-noise ratio (SNR), and image uniformity. The image parameters of three desktop MRI machines could be measured using our specially designed phantoms, and most parameters were in line with MRI quality control criterion, including: resonance frequency, high contrast spatial resolution, low contrast object detectability, slice thickness, geometrical distortion, image uniformity and slice position accuracy. However, SNR was significantly lower than in some references. The imaging test and quality control are necessary for desktop MRI systems, and should be performed with the applicable phantom and corresponding standards.

Monolithic echo-less photoconductive switches as a high-resolution detector for terahertz time-domain spectroscopy

NASA Astrophysics Data System (ADS)

Maussang, K.; Palomo, J.; Manceau, J.-M.; Colombelli, R.; Sagnes, I.; Li, L. H.; Linfield, E. H.; Davies, A. G.; Mangeney, J.; Tignon, J.; Dhillon, S. S.

2017-04-01

Interdigitated photoconductive (iPC) switches are powerful and convenient devices for time-resolved spectroscopy, with the ability to operate both as sources and detectors of terahertz (THz) frequency pulses. However, reflection of the emitted or detected radiation within the device substrate itself can lead to echoes that inherently limit the spectroscopic resolution achievable for their use in time-domain spectroscopy (TDS) systems. In this work, we demonstrate a design of low-temperature-grown-GaAs (LT-GaAs) iPC switches for THz pulse detection that suppresses such unwanted echoes. This is realized through the growth of a buried multilayer LT-GaAs structure that retains its ultrafast properties, which, after wafer bonding to a metal-coated host substrate, results in an iPC switch with a metal plane buried at a subwavelength depth below the LT-GaAs surface. Using this device as a detector, and coupling it to an echo-less iPC source, enables echo-free THz-TDS and high-resolution spectroscopy, with a resolution limited only by the temporal length of the measurement governed by the mechanical delay line used. As a proof-of-principle, the 212-221 and the 101-212 rotational lines of water vapor have been spectrally resolved, demonstrating a spectral resolution below 10 GHz.

Direct Imaging of Radionuclide-Produced Electrons and Positrons with an Ultrathin Phosphor

PubMed Central

Chen, Liying; Gobar, Lisa S.; Knowles, Negar G.; Liu, Zhonglin; Gmitro, Arthur F.; Barrett, Harrison H.

2008-01-01

Current electron detectors are either unable to image in vivo or lack sufficient spatial resolution because of electron scattering in thick detector materials. This study was aimed at developing a sensitive high-resolution system capable of detecting electron-emitting isotopes in vivo. Methods The system uses a lens-coupled charge-coupled-device camera to capture the scintillation light excited by an electron-emitting object near an ultrathin phosphor. The spatial resolution and sensitivity of the system were measured with a 3.7-kBq 90Y/90Sr β-source and a 70-µm resin bead labeled with 99mTc. Finally, we imaged the 99mTc-pertechnetate concentration in the mandibular gland of a mouse in vivo. Results Useful images were obtained with only a few hundred emitted β particles from the 90Y/90Sr source or conversion electrons from the 99mTc bead source. The in vivo image showed a clear profile of the mandibular gland and many fine details with exposures of as low as 30 s. All measurements were consistent with a spatial resolution of about 50 µm, corresponding to 2.5 detector pixels with the current camera. Conclusion Our new electron-imaging system can image electron-emitting isotope distributions at high resolution and sensitivity. The system is useful for in vivo imaging of small animals and small, exposed regions on humans. The ability to image β particles, positrons, and conversion electrons makes the system applicable to most isotopes. PMID:18552136

Single photon detection and timing in the Lunar Laser Ranging Experiment.

NASA Technical Reports Server (NTRS)

Poultney, S. K.

1972-01-01

The goals of the Lunar Laser Ranging Experiment lead to the need for the measurement of a 2.5 sec time interval to an accuracy of a nanosecond or better. The systems analysis which included practical retroreflector arrays, available laser systems, and large telescopes led to the necessity of single photon detection. Operation under all background illumination conditions required auxiliary range gates and extremely narrow spectral and spatial filters in addition to the effective gate provided by the time resolution. Nanosecond timing precision at relatively high detection efficiency was obtained using the RCA C31000F photomultiplier and Ortec 270 constant fraction of pulse-height timing discriminator. The timing accuracy over the 2.5 sec interval was obtained using a digital interval with analog vernier ends. Both precision and accuracy are currently checked internally using a triggerable, nanosecond light pulser. Future measurements using sub-nanosecond laser pulses will be limited by the time resolution of single photon detectors.

Full-field OCT: ex vivo and in vivo biological imaging applications

NASA Astrophysics Data System (ADS)

Grieve, Katharine; Dubois, Arnaud; Moneron, Gael; Guyot, Elvire; Boccara, Albert C.

2005-04-01

We present results of studies in embryology and ophthalmology performed using our ultrahigh-resolution full-field OCT system. We also discuss recent developments to our ultrashort acquisition time full-field optical coherence tomography system designed to allow in vivo biological imaging. Preliminary results of high-speed imaging in biological samples are presented. The core of the experimental setup is the Linnik interferometer, illuminated by a white light source. En face tomographic images are obtained in real-time without scanning by computing the difference of two phase-opposed interferometric images recorded by high-resolution CCD cameras. An isotropic spatial resolution of ~1 μm is achieved thanks to the short source coherence length and the use of high numerical aperture microscope objectives. A detection sensitivity of ~90 dB is obtained by means of image averaging and pixel binning. In ophthalmology, reconstructed xz images from rat ocular tissue are presented, where cellular-level structures in the retina are revealed, demonstrating the unprecedented resolution of our instrument. Three-dimensional reconstructions of the mouse embryo allowing the study of the establishment of the anterior-posterior axis are shown. Finally we present the first results of embryonic imaging using the new rapid acquisition full-field OCT system, which offers an acquisition time of 10 μs per frame.

Image reconstruction and system modeling techniques for virtual-pinhole PET insert systems

PubMed Central

Keesing, Daniel B; Mathews, Aswin; Komarov, Sergey; Wu, Heyu; Song, Tae Yong; O'Sullivan, Joseph A; Tai, Yuan-Chuan

2012-01-01

Virtual-pinhole PET (VP-PET) imaging is a new technology in which one or more high-resolution detector modules are integrated into a conventional PET scanner with lower-resolution detectors. It can locally enhance the spatial resolution and contrast recovery near the add-on detectors, and depending on the configuration, may also increase the sensitivity of the system. This novel scanner geometry makes the reconstruction problem more challenging compared to the reconstruction of data from a standalone PET scanner, as new techniques are needed to model and account for the non-standard acquisition. In this paper, we present a general framework for fully 3D modeling of an arbitrary VP-PET insert system. The model components are incorporated into a statistical reconstruction algorithm to estimate an image from the multi-resolution data. For validation, we apply the proposed model and reconstruction approach to one of our custom-built VP-PET systems – a half-ring insert device integrated into a clinical PET/CT scanner. Details regarding the most important implementation issues are provided. We show that the proposed data model is consistent with the measured data, and that our approach can lead to reconstructions with improved spatial resolution and lesion detectability. PMID:22490983

Aircraft Detection in High-Resolution SAR Images Based on a Gradient Textural Saliency Map

PubMed Central

Tan, Yihua; Li, Qingyun; Li, Yansheng; Tian, Jinwen

2015-01-01

This paper proposes a new automatic and adaptive aircraft target detection algorithm in high-resolution synthetic aperture radar (SAR) images of airport. The proposed method is based on gradient textural saliency map under the contextual cues of apron area. Firstly, the candidate regions with the possible existence of airport are detected from the apron area. Secondly, directional local gradient distribution detector is used to obtain a gradient textural saliency map in the favor of the candidate regions. In addition, the final targets will be detected by segmenting the saliency map using CFAR-type algorithm. The real high-resolution airborne SAR image data is used to verify the proposed algorithm. The results demonstrate that this algorithm can detect aircraft targets quickly and accurately, and decrease the false alarm rate. PMID:26378543

The Megamaser Cosmology Project. X. High-resolution Maps and Mass Constraints for SMBHs

NASA Astrophysics Data System (ADS)

Zhao, W.; Braatz, J. A.; Condon, J. J.; Lo, K. Y.; Reid, M. J.; Henkel, C.; Pesce, D. W.; Greene, J. E.; Gao, F.; Kuo, C. Y.; Impellizzeri, C. M. V.

2018-02-01

We present high-resolution (submas) Very Long Baseline Interferometry maps of nuclear H2O megamasers for seven galaxies. In UGC 6093, the well-aligned systemic masers and high-velocity masers originate in an edge-on, flat disk and we determine the mass of the central supermassive black holes (SMBH) to be M SMBH = 2.58 × 107 M ⊙ (±7%). For J1346+5228, the distribution of masers is consistent with a disk, but the faint high-velocity masers are only marginally detected, and we constrain the mass of the SMBH to be in the range (1.5–2.0) × 107 M ⊙. The origin of the masers in Mrk 1210 is less clear, as the systemic and high-velocity masers are misaligned and show a disorganized velocity structure. We present one possible model in which the masers originate in a tilted, warped disk, but we do not rule out the possibility of other explanations including outflow masers. In NGC 6926, we detect a set of redshifted masers, clustered within a parsec of each other, and a single blueshifted maser about 4.4 pc away, an offset that would be unusually large for a maser disk system. Nevertheless, if it is a disk system, we estimate the enclosed mass to be M SMBH < 4.8 × 107 M ⊙. For NGC 5793, we detect redshifted masers spaced about 1.4 pc from a clustered set of blueshifted features. The orientation of the structure supports a disk scenario as suggested by Hagiwara et al. We estimate the enclosed mass to be M SMBH < 1.3 × 107 M ⊙. For NGC 2824 and J0350‑0127, the masers may be associated with parsec- or subparsec-scale jets or outflows.

Real-Time, Non-Intrusive Detection of Liquid Nitrogen in Liquid Oxygen at High Pressure and High Flow

NASA Technical Reports Server (NTRS)

Singh, Jagdish P.; Yueh, Fang-Yu; Kalluru, Rajamohan R.; Harrison, Louie

2012-01-01

An integrated fiber-optic Raman sensor has been designed for real-time, nonintrusive detection of liquid nitrogen in liquid oxygen (LOX) at high pressures and high flow rates in order to monitor the quality of LOX used during rocket engine ground testing. The integrated sensor employs a high-power (3-W) Melles Griot diode-pumped, solid-state (DPSS), frequency-doubled Nd:YAG 532- nm laser; a modified Raman probe that has built-in Raman signal filter optics; two high-resolution spectrometers; and photomultiplier tubes (PMTs) with selected bandpass filters to collect both N2 and O2 Raman signals. The PMT detection units are interfaced with National Instruments Lab- VIEW for fast data acquisition. Studies of sensor performance with different detection systems (i.e., spectrometer and PMT) were carried out. The concentration ratio of N2 and O2 can be inferred by comparing the intensities of the N2 and O2 Raman signals. The final system was fabricated to measure N2 and O2 gas mixtures as well as mixtures of liquid N2 and LOX

Oblique reconstructions in tomosynthesis. II. Super-resolution

PubMed Central

Acciavatti, Raymond J.; Maidment, Andrew D. A.

2013-01-01

Purpose: In tomosynthesis, super-resolution has been demonstrated using reconstruction planes parallel to the detector. Super-resolution allows for subpixel resolution relative to the detector. The purpose of this work is to develop an analytical model that generalizes super-resolution to oblique reconstruction planes. Methods: In a digital tomosynthesis system, a sinusoidal test object is modeled along oblique angles (i.e., “pitches”) relative to the plane of the detector in a 3D divergent-beam acquisition geometry. To investigate the potential for super-resolution, the input frequency is specified to be greater than the alias frequency of the detector. Reconstructions are evaluated in an oblique plane along the extent of the object using simple backprojection (SBP) and filtered backprojection (FBP). By comparing the amplitude of the reconstruction against the attenuation coefficient of the object at various frequencies, the modulation transfer function (MTF) is calculated to determine whether modulation is within detectable limits for super-resolution. For experimental validation of super-resolution, a goniometry stand was used to orient a bar pattern phantom along various pitches relative to the breast support in a commercial digital breast tomosynthesis system. Results: Using theoretical modeling, it is shown that a single projection image cannot resolve a sine input whose frequency exceeds the detector alias frequency. The high frequency input is correctly visualized in SBP or FBP reconstruction using a slice along the pitch of the object. The Fourier transform of this reconstructed slice is maximized at the input frequency as proof that the object is resolved. Consistent with the theoretical results, experimental images of a bar pattern phantom showed super-resolution in oblique reconstructions. At various pitches, the highest frequency with detectable modulation was determined by visual inspection of the bar patterns. The dependency of the highest detectable frequency on pitch followed the same trend as the analytical model. It was demonstrated that super-resolution is not achievable if the pitch of the object approaches 90°, corresponding to the case in which the test frequency is perpendicular to the breast support. Only low frequency objects are detectable at pitches close to 90°. Conclusions: This work provides a platform for investigating super-resolution in oblique reconstructions for tomosynthesis. In breast imaging, this study should have applications in visualizing microcalcifications and other subtle signs of cancer. PMID:24320445

CW Laser radar for combustion diagnostics

NASA Astrophysics Data System (ADS)

Malmqvist, Elin; Brydegaard, Mikkel; Aldén, Marcus; Bood, Joakim

2018-04-01

A CW-laser radar system developed for combustion diagnostics is described. The system is based on triangulation to attain range information. A portable system has been constructed and here we show some result from measurements in various flames, for example Rayleigh scattering thermometry and monitoring of particle distributions with high temporal and spatial resolution. The concept can equally well be based on pulsed lasers, allowing suppression of background emission through gated detection.

Preliminary frequency-domain analysis for the reconstructed spatial resolution of muon tomography

NASA Astrophysics Data System (ADS)

Yu, B.; Zhao, Z.; Wang, X.; Wang, Y.; Wu, D.; Zeng, Z.; Zeng, M.; Yi, H.; Luo, Z.; Yue, X.; Cheng, J.

2014-11-01

Muon tomography is an advanced technology to non-destructively detect high atomic number materials. It exploits the multiple Coulomb scattering information of muon to reconstruct the scattering density image of the traversed object. Because of the statistics of muon scattering, the measurement error of system and the data incompleteness, the reconstruction is always accompanied with a certain level of interference, which will influence the reconstructed spatial resolution. While statistical noises can be reduced by extending the measuring time, system parameters determine the ultimate spatial resolution that one system can reach. In this paper, an effective frequency-domain model is proposed to analyze the reconstructed spatial resolution of muon tomography. The proposed method modifies the resolution analysis in conventional computed tomography (CT) to fit the different imaging mechanism in muon scattering tomography. The measured scattering information is described in frequency domain, then a relationship between the measurements and the original image is proposed in Fourier domain, which is named as "Muon Central Slice Theorem". Furthermore, a preliminary analytical expression of the ultimate reconstructed spatial is derived, and the simulations are performed for validation. While the method is able to predict the ultimate spatial resolution of a given system, it can also be utilized for the optimization of system design and construction.

Validating high-resolution California coastal flood modeling with Uninhabited Aerial Vehicle Synthetic Aperture Radar (UAVSAR)

NASA Astrophysics Data System (ADS)

O'Neill, A.

2015-12-01

The Coastal Storm Modeling System (CoSMoS) is a numerical modeling scheme used to predict coastal flooding due to sea level rise and storms influenced by climate change, currently in use in central California and in development for Southern California (Pt. Conception to the Mexican border). Using a framework of circulation, wave, analytical, and Bayesian models at different geographic scales, high-resolution results are translated as relevant hazards projections at the local scale that include flooding, wave heights, coastal erosion, shoreline change, and cliff failures. Ready access to accurate, high-resolution coastal flooding data is critical for further validation and refinement of CoSMoS and improved coastal hazard projections. High-resolution Uninhabited Aerial Vehicle Synthetic Aperture Radar (UAVSAR) provides an exceptional data source as appropriately-timed flights during extreme tides or storms provide a geographically-extensive method for determining areas of inundation and flooding extent along expanses of complex and varying coastline. Landward flood extents are numerically identified via edge-detection in imagery from single flights, and can also be ascertained via change detection using additional flights and imagery collected during average wave/tide conditions. The extracted flooding positions are compared against CoSMoS results for similar tide, water level, and storm-intensity conditions, allowing for robust testing and validation of CoSMoS and providing essential feedback for supporting regional and local model improvement.

Liquid scintillator composition optimization for use in ultra-high energy cosmic ray detector systems

NASA Astrophysics Data System (ADS)

Beznosko, Dmitriy; Batyrkhanov, Ayan; Iakovlev, Alexander; Yelshibekov, Khalykbek

2017-06-01

The Horizon-T (HT) detector system and the currently under R&D HT-KZ detector system are designed for the detection of Extensive Air Showers (EAS) with energies above ˜1016 eV (˜1017 eV for HT-KZ). The main challenges in both detector systems are the fast time resolutions needed for studying the temporary structure of EAS, and the extremely wide dynamic range needed to study the spatial distribution of charged particles in EAS disks. In order to detect the low-density of charged particles far from the EAS axis, a large-area detector is needed. Liquid scintillator with low cost would be a possible solution for such a detector, including the recently developed safe and low-cost water-based liquid scintillators. Liquid organic scintillators give a fast and high light yield (LY) for charged particle detection. It is similar to plastic scintillator in properties but is cost effective for large volumes. With liquid scintillator, one can create detection volumes that are symmetric and yet retain high LY detection. Different wavelength shifters affect the scintillation light by changing the output spectrum into the best detection region. Results of the latest studies of the components optimization in the liquid scintillator formulae are presented.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zarzycki, Colin M.; Thatcher, Diana R.; Jablonowski, Christiane

This paper describes an objective technique for detecting the extratropical transition (ET) of tropical cyclones (TCs) in high-resolution gridded climate data. The algorithm is based on previous observational studies using phase spaces to define the symmetry and vertical thermal structure of cyclones. Storm tracking is automated, allowing for direct analysis of climate data. Tracker performance in the North Atlantic is assessed using 23 years of data from the variable-resolution Community Atmosphere Model (CAM) at two different resolutions (DX 55 km and 28 km), the Climate Forecast System Reanalysis (CFSR, DX 38 km), and the ERA-Interim Reanalysis (ERA-I, DX 80 km).more » The mean spatiotemporal climatologies and seasonal cycles of objectively detected ET in the observationally constrained CFSR and ERA-I are well matched to previous observational studies, demonstrating the capability of the scheme to adequately find events. High resolution CAM reproduces TC and ET statistics that are in general agreement with reanalyses. One notable model bias, however, is significantly longer time between ET onset and ET completion in CAM, particularly for TCs that lose symmetry prior to developing a cold-core structure and becoming extratropical cyclones, demonstrating the capability of this method to expose model biases in simulated cyclones beyond the tropical phase.« less

Photoacoustic imaging of single circulating melanoma cells in vivo

NASA Astrophysics Data System (ADS)

Wang, Lidai; Yao, Junjie; Zhang, Ruiying; Xu, Song; Li, Guo; Zou, Jun; Wang, Lihong V.

2015-03-01

Melanoma, one of the most common types of skin cancer, has a high mortality rate, mainly due to a high propensity for tumor metastasis. The presence of circulating tumor cells (CTCs) is a potential predictor for metastasis. Label-free imaging of single circulating melanoma cells in vivo provides rich information on tumor progress. Here we present photoacoustic microscopy of single melanoma cells in living animals. We used a fast-scanning optical-resolution photoacoustic microscope to image the microvasculature in mouse ears. The imaging system has sub-cellular spatial resolution and works in reflection mode. A fast-scanning mirror allows the system to acquire fast volumetric images over a large field of view. A 500-kHz pulsed laser was used to image blood and CTCs. Single circulating melanoma cells were imaged in both capillaries and trunk vessels in living animals. These high-resolution images may be used in early detection of CTCs with potentially high sensitivity. In addition, this technique enables in vivo study of tumor cell extravasation from a primary tumor, which addresses an urgent pre-clinical need.

Technical note: Coupling infrared gas analysis and cavity ring down spectroscopy for autonomous, high-temporal-resolution measurements of DIC and δ13C-DIC

NASA Astrophysics Data System (ADS)

Call, Mitchell; Schulz, Kai G.; Carvalho, Matheus C.; Santos, Isaac R.; Maher, Damien T.

2017-03-01

A new approach to autonomously determine concentrations of dissolved inorganic carbon (DIC) and its carbon stable isotope ratio (δ13C-DIC) at high temporal resolution is presented. The simple method requires no customised design. Instead it uses two commercially available instruments currently used in aquatic carbon research. An inorganic carbon analyser utilising non-dispersive infrared detection (NDIR) is coupled to a Cavity Ring-down Spectrometer (CRDS) to determine DIC and δ13C-DIC based on the liberated CO2 from acidified aliquots of water. Using a small sample volume of 2 mL, the precision and accuracy of the new method was comparable to standard isotope ratio mass spectrometry (IRMS) methods. The system achieved a sampling resolution of 16 min, with a DIC precision of ±1.5 to 2 µmol kg-1 and δ13C-DIC precision of ±0.14 ‰ for concentrations spanning 1000 to 3600 µmol kg-1. Accuracy of 0.1 ± 0.06 ‰ for δ13C-DIC based on DIC concentrations ranging from 2000 to 2230 µmol kg-1 was achieved during a laboratory-based algal bloom experiment. The high precision data that can be autonomously obtained by the system should enable complex carbonate system questions to be explored in aquatic sciences using high-temporal-resolution observations.

Molecular simultaneous detection of Cherry necrotic rusty mottle virus and Cherry green ring mottle virus by real-time RT-PCR and high resolution melting analysis

USDA-ARS?s Scientific Manuscript database

In this study, real-time RT-PCR assays were combined with high resolution melting (HRM) analysis for the simultaneous detection of Cherry necrotic rusty mottle virus (CNRMV) and Cherry green ring mottle virus (CGRMV) infection in sweet cherry trees. Detection of CNRMV and CGRMV was performed using a...

Carotid Stenosis And Ulcer Detectability As A Function Of Pixel Size

NASA Astrophysics Data System (ADS)

Mintz, Leslie J.; Enzmann, Dieter R.; Keyes, Gary S.; Mainiero, Louis M.; Brody, William R.

1981-11-01

Digital radiography, in conjunction with digital subtraction methods can provide high quality images of the vascular system,1-4 Spatial resolution is one important limiting factor of this imaging technique. Since spatial resolution of a digital image is a function of pixel size, it is important to determine the pixel size threshold necessary to provide information comparable to that of conventional angiograms. This study was designed to establish the pixel size necessary to identify accurately stenotic and ulcerative lesions of the carotid artery.

Light-sheet enhanced resolution of light field microscopy for rapid imaging of large volumes

NASA Astrophysics Data System (ADS)

Madrid Wolff, Jorge; Castro, Diego; Arbeláez, Pablo; Forero-Shelton, Manu

2018-02-01

Whole-brain imaging is challenging because it demands microscopes with high temporal and spatial resolution, which are often at odds, especially in the context of large fields of view. We have designed and built a light-sheet microscope with digital micromirror illumination and light-field detection. On the one hand, light sheets provide high resolution optical sectioning on live samples without compromising their viability. On the other hand, light field imaging makes it possible to reconstruct full volumes of relatively large fields of view from a single camera exposure; however, its enhanced temporal resolution comes at the expense of spatial resolution, limiting its applicability. We present an approach to increase the resolution of light field images using DMD-based light sheet illumination. To that end, we develop a method to produce synthetic resolution targets for light field microscopy and a procedure to correct the depth at which planes are refocused with rendering software. We measured the axial resolution as a function of depth and show a three-fold potential improvement with structured illumination, albeit by sacrificing some temporal resolution, also three-fold. This results in an imaging system that may be adjusted to specific needs without having to reassemble and realign it. This approach could be used to image relatively large samples at high rates.

Methylation detection oligonucleotide microarray analysis: a high-resolution method for detection of CpG island methylation

PubMed Central

Kamalakaran, Sitharthan; Kendall, Jude; Zhao, Xiaoyue; Tang, Chunlao; Khan, Sohail; Ravi, Kandasamy; Auletta, Theresa; Riggs, Michael; Wang, Yun; Helland, Åslaug; Naume, Bjørn; Dimitrova, Nevenka; Børresen-Dale, Anne-Lise; Hicks, Jim; Lucito, Robert

2009-01-01

Methylation of CpG islands associated with genes can affect the expression of the proximal gene, and methylation of non-associated CpG islands correlates to genomic instability. This epigenetic modification has been shown to be important in many pathologies, from development and disease to cancer. We report the development of a novel high-resolution microarray that detects the methylation status of over 25 000 CpG islands in the human genome. Experiments were performed to demonstrate low system noise in the methodology and that the array probes have a high signal to noise ratio. Methylation measurements between different cell lines were validated demonstrating the accuracy of measurement. We then identified alterations in CpG islands, both those associated with gene promoters, as well as non-promoter-associated islands in a set of breast and ovarian tumors. We demonstrate that this methodology accurately identifies methylation profiles in cancer and in principle it can differentiate any CpG methylation alterations and can be adapted to analyze other species. PMID:19474344

Gas chromatographic quadrupole time-of-flight full scan high resolution mass spectrometric screening of human urine in antidoping analysis.

PubMed

Abushareeda, Wadha; Lyris, Emmanouil; Kraiem, Suhail; Wahaibi, Aisha Al; Alyazidi, Sameera; Dbes, Najib; Lommen, Arjen; Nielen, Michel; Horvatovich, Peter L; Alsayrafi, Mohammed; Georgakopoulos, Costas

2017-09-15

This paper presents the development and validation of a high-resolution full scan (FS) electron impact ionization (EI) gas chromatography coupled to quadrupole Time-of-Flight mass spectrometry (GC/QTOF) platform for screening anabolic androgenic steroids (AAS) in human urine samples. The World Antidoping Agency (WADA) enlists AAS as prohibited doping agents in sports, and our method has been developed to comply with the qualitative specifications of WADA to be applied for the detection of sports antidoping prohibited substances, mainly for AAS. The method also comprises of the quantitative analysis of the WADA's Athlete Biological Passport (ABP) endogenous steroidal parameters. The applied preparation of urine samples includes enzymatic hydrolysis for the cleavage of the Phase II glucuronide conjugates, generic liquid-liquid extraction and trimethylsilyl (TMS) derivatization steps. Tandem mass spectrometry (MS/MS) acquisition was applied on few selected ions to enhance the specificity and sensitivity of GC/TOF signal of few compounds. The full scan high resolution acquisition of analytical signal, for known and unknown TMS derivatives of AAS provides the antidoping system with a new analytical tool for the detection designer drugs and novel metabolites, which prolongs the AAS detection, after electronic data files' reprocessing. The current method is complementary to the respective liquid chromatography coupled to mass spectrometry (LC/MS) methodology widely used to detect prohibited molecules in sport, which cannot be efficiently ionized with atmospheric pressure ionization interface. Copyright © 2017 Elsevier B.V. All rights reserved.

Monte Carlo simulation studies on scintillation detectors and image reconstruction of brain-phantom tumors in TOFPET

PubMed Central

Mondal, Nagendra Nath

2009-01-01

This study presents Monte Carlo Simulation (MCS) results of detection efficiencies, spatial resolutions and resolving powers of a time-of-flight (TOF) PET detector systems. Cerium activated Lutetium Oxyorthosilicate (Lu2SiO5: Ce in short LSO), Barium Fluoride (BaF2) and BriLanCe 380 (Cerium doped Lanthanum tri-Bromide, in short LaBr3) scintillation crystals are studied in view of their good time and energy resolutions and shorter decay times. The results of MCS based on GEANT show that spatial resolution, detection efficiency and resolving power of LSO are better than those of BaF2 and LaBr3, although it possesses inferior time and energy resolutions. Instead of the conventional position reconstruction method, newly established image reconstruction (talked about in the previous work) method is applied to produce high-tech images. Validation is a momentous step to ensure that this imaging method fulfills all purposes of motivation discussed by reconstructing images of two tumors in a brain phantom. PMID:20098551

A compact CCD-monitored atomic force microscope with optical vision and improved performances.

PubMed

Mingyue, Liu; Haijun, Zhang; Dongxian, Zhang

2013-09-01

A novel CCD-monitored atomic force microscope (AFM) with optical vision and improved performances has been developed. Compact optical paths are specifically devised for both tip-sample microscopic monitoring and cantilever's deflection detecting with minimized volume and optimal light-amplifying ratio. The ingeniously designed AFM probe with such optical paths enables quick and safe tip-sample approaching, convenient and effective tip-sample positioning, and high quality image scanning. An image stitching method is also developed to build a wider-range AFM image under monitoring. Experiments show that this AFM system can offer real-time optical vision for tip-sample monitoring with wide visual field and/or high lateral optical resolution by simply switching the objective; meanwhile, it has the elegant performances of nanometer resolution, high stability, and high scan speed. Furthermore, it is capable of conducting wider-range image measurement while keeping nanometer resolution. Copyright © 2013 Wiley Periodicals, Inc.

Simultaneous in vivo positron emission tomography and magnetic resonance imaging.

PubMed

Catana, Ciprian; Procissi, Daniel; Wu, Yibao; Judenhofer, Martin S; Qi, Jinyi; Pichler, Bernd J; Jacobs, Russell E; Cherry, Simon R

2008-03-11

Positron emission tomography (PET) and magnetic resonance imaging (MRI) are widely used in vivo imaging technologies with both clinical and biomedical research applications. The strengths of MRI include high-resolution, high-contrast morphologic imaging of soft tissues; the ability to image physiologic parameters such as diffusion and changes in oxygenation level resulting from neuronal stimulation; and the measurement of metabolites using chemical shift imaging. PET images the distribution of biologically targeted radiotracers with high sensitivity, but images generally lack anatomic context and are of lower spatial resolution. Integration of these technologies permits the acquisition of temporally correlated data showing the distribution of PET radiotracers and MRI contrast agents or MR-detectable metabolites, with registration to the underlying anatomy. An MRI-compatible PET scanner has been built for biomedical research applications that allows data from both modalities to be acquired simultaneously. Experiments demonstrate no effect of the MRI system on the spatial resolution of the PET system and <10% reduction in the fraction of radioactive decay events detected by the PET scanner inside the MRI. The signal-to-noise ratio and uniformity of the MR images, with the exception of one particular pulse sequence, were little affected by the presence of the PET scanner. In vivo simultaneous PET and MRI studies were performed in mice. Proof-of-principle in vivo MR spectroscopy and functional MRI experiments were also demonstrated with the combined scanner.

Evaluation of High Resolution Rapid Refresh-Smoke (HRRR-Smoke) model products for a case study using surface PM2.5 observations

NASA Astrophysics Data System (ADS)

Deanes, L. N.; Ahmadov, R.; McKeen, S. A.; Manross, K.; Grell, G. A.; James, E.

2016-12-01

Wildfires are increasing in number and size in the western United States as climate change contributes to warmer and drier conditions in this region. These fires lead to poor air quality and diminished visibility. The High Resolution Rapid Refresh-Smoke modeling system (HRRR-Smoke) is designed to simulate fire emissions and smoke transport with high resolution. The model is based on the Weather Research and Forecasting model, coupled with chemistry (WRF-Chem) and uses fire detection data from the Visible Infrared and Imaging Radiometer Suite (VIIRS) satellite instrument to simulate wildfire emissions and their plume rise. HRRR-Smoke is used in both real-time applications and case studies. In this study, we evaluate the HRRR-Smoke for August 2015, during one of the worst wildfire seasons on record in the United States, by focusing on wildfires that occurred in the northwestern US. We compare HRRR-Smoke simulations with hourly fine particulate matter (PM2.5) observations from the Air Quality System (https://www.epa.gov/aqs) from multiple air quality monitoring sites in Washington state. PM2.5 data includes measurements from urban, suburban and remote sites in the state. We discuss the model performance in capturing large PM2.5 enhancements detected at surface sites due to wildfires. We present various statistical parameters to demonstrate HRRR-Smoke's performance in simulating surface PM2.5 levels.

Continuous wave external-cavity quantum cascade laser-based high-resolution cavity ring-down spectrometer for ultrasensitive trace gas detection.

PubMed

De, Anulekha; Banik, Gourab Dutta; Maity, Abhijit; Pal, Mithun; Pradhan, Manik

2016-05-01

A high-resolution cavity ring-down spectroscopic (CRDS) system based on a continuous wave (cw) mode-hop-free (MHF) external-cavity quantum cascade laser (EC-QCL) operating at λ∼5.2  μm has been developed for ultrasensitive detection of nitric oxide (NO). We report the performance of the high-resolution EC-QCL based cw-CRDS instrument by measuring the rotationally resolved Λ-doublet e and f components of the P(7.5) line in the fundamental band of NO at 1850.169  cm^-1 and 1850.179  cm^-1. A noise-equivalent absorption coefficient of 1.01×10^-9  cm^-1  Hz^-1/2 was achieved based on an empty cavity ring-down time of τ₀=5.6  μs and standard deviation of 0.11% with averaging of six ring-down time determinations. The CRDS sensor demonstrates the advantages of measuring parts per billion NO concentrations in N₂, as well as in human breath samples with ultrahigh sensitivity and specificity. The CRDS system could also be generalized to measure simultaneously many other trace molecular species within the broad tuning range of cw EC-QCL, as well as for studying the rotationally resolved hyperfine structures.

Molecular hydrogen absorption systems in Sloan Digital Sky Survey

NASA Astrophysics Data System (ADS)

Balashev, S. A.; Klimenko, V. V.; Ivanchik, A. V.; Varshalovich, D. A.; Petitjean, P.; Noterdaeme, P.

2014-05-01

We present a systematic search for molecular hydrogen absorption systems at high redshift in quasar spectra from the Sloan Digital Sky Survey (SDSS)-II Data Release 7 and SDSS-III Data Release 9. We have selected candidates using a modified profile fitting technique taking into account that the Lyα forest can effectively mimic H2 absorption systems at the resolution of SDSS data. To estimate the confidence level of the detections, we use two methods: a Monte Carlo sampling and an analysis of control samples. The analysis of control samples allows us to define regions of the spectral quality parameter space where H2 absorption systems can be confidently identified. We find that H2 absorption systems with column densities log NH2 > 19 can be detected in only less than 3 per cent of SDSS quasar spectra. We estimate the upper limit on the detection rate of saturated H2 absorption systems (NH2 > 19) in damped Lyα (DLA) systems to be about 7 per cent. We provide a sample of 23 confident H2 absorption system candidates that would be interesting to follow up with high-resolution spectrographs. There is a 1σ r - i colour excess and non-significant AV extinction excess in quasar spectra with an H2 candidate compared to standard DLA-bearing quasar spectra. The equivalent widths of C II, Si II and Al III (but not Fe II) absorptions associated with H2 candidate DLAs are larger compared to standard DLAs. This is probably related to a larger spread in velocity of the absorption lines in the H2-bearing sample.

C-SPECT - a Clinical Cardiac SPECT/Tct Platform: Design Concepts and Performance Potential

PubMed Central

Chang, Wei; Ordonez, Caesar E.; Liang, Haoning; Li, Yusheng; Liu, Jingai

2013-01-01

Because of scarcity of photons emitted from the heart, clinical cardiac SPECT imaging is mainly limited by photon statistics. The sub-optimal detection efficiency of current SPECT systems not only limits the quality of clinical cardiac SPECT imaging but also makes more advanced potential applications difficult to be realized. We propose a high-performance system platform - C-SPECT, which has its sampling geometry optimized for detection of emitted photons in quality and quantity. The C-SPECT has a stationary C-shaped gantry that surrounds the left-front side of a patient’s thorax. The stationary C-shaped collimator and detector systems in the gantry provide effective and efficient detection and sampling of photon emission. For cardiac imaging, the C-SPECT platform could achieve 2 to 4 times the system geometric efficiency of conventional SPECT systems at the same sampling resolution. This platform also includes an integrated transmission CT for attenuation correction. The ability of C-SPECT systems to perform sequential high-quality emission and transmission imaging could bring cost-effective high-performance to clinical imaging. In addition, a C-SPECT system could provide high detection efficiency to accommodate fast acquisition rate for gated and dynamic cardiac imaging. This paper describes the design concepts and performance potential of C-SPECT, and illustrates how these concepts can be implemented in a basic system. PMID:23885129

Experimental investigation of leak detection using mobile distributed monitoring system

NASA Astrophysics Data System (ADS)

Chen, Jiang; Zheng, Junli; Xiong, Feng; Ge, Qi; Yan, Qixiang; Cheng, Fei

2018-01-01

The leak detection of rockfill dams is currently hindered by spatial and temporal randomness and wide monitoring range. The spatial resolution of fiber Bragg grating (FBG) temperature sensing technology is related to the distance between measuring points. As a result, the number of measuring points should be increased to ensure that the precise location of the leak is detected. However, this leads to a higher monitoring cost. Consequently, it is difficult to promote and apply this technology to effectively monitor rockfill dam leakage. In this paper, a practical mobile distributed monitoring system with dual-tubes is used by combining the FBG sensing system and hydrothermal cycling system. This dual-tube structure is composed of an outer polyethylene of raised temperature resistance heating pipe, an inner polytetrafluoroethylene tube, and a FBG sensor string, among which, the FBG sensor string can be dragged freely in the internal tube to change the position of the measuring points and improve the spatial resolution. In order to test the effectiveness of the system, the large-scale model test of concentrated leakage in 13 working conditions is carried out by identifying the location, quantity, and leakage rate of leakage passage. Based on Newton’s law of cooling, the leakage state is identified using the seepage identification index ζ v that was confirmed according to the cooling curve. Results suggested that the monitoring system shows high sensitivity and can improve the spatial resolution with limited measuring points, and thus better locate the leakage area. In addition, the seepage identification index ζ v correlated well with the leakage rate qualitatively.

Design of optimal collimation for dedicated molecular breast imaging systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weinmann, Amanda L.; Hruska, Carrie B.; O'Connor, Michael K.

2009-03-15

Molecular breast imaging (MBI) is a functional imaging technique that uses specialized small field-of-view gamma cameras to detect the preferential uptake of a radiotracer in breast lesions. MBI has potential to be a useful adjunct method to screening mammography for the detection of occult breast cancer. However, a current limitation of MBI is the high radiation dose (a factor of 7-10 times that of screening mammography) associated with current technology. The purpose of this study was to optimize the gamma camera collimation with the aim of improving sensitivity while retaining adequate resolution for the detection of sub-10-mm lesions. Square-hole collimatorsmore » with holes matched to the pixilated cadmium zinc telluride detector elements of the MBI system were designed. Data from MBI patient studies and parameters of existing dual-head MBI systems were used to guide the range of desired collimator resolutions, source-to-collimator distances, pixel sizes, and collimator materials that were examined. General equations describing collimator performance for a conventional gamma camera were used in the design process along with several important adjustments to account for the specialized imaging geometry of the MBI system. Both theoretical calculations and a Monte Carlo model were used to measure the geometric efficiency (or sensitivity) and resolution of each designed collimator. Results showed that through optimal collimation, collimator sensitivity could be improved by factors of 1.5-3.2, while maintaining a collimator resolution of either {<=}5 or {<=}7.5 mm at a distance of 3 cm from the collimator face. These gains in collimator sensitivity permit an inversely proportional drop in the required dose to perform MBI.« less

Optical resolution photoacoustic microscopy using novel high-repetition-rate passively Q-switched microchip and fiber lasers.

PubMed

Shi, Wei; Kerr, Shaun; Utkin, Ilya; Ranasinghesagara, Janaka; Pan, Lei; Godwal, Yogesh; Zemp, Roger J; Fedosejevs, Robert

2010-01-01

Optical-resolution photoacoustic microscopy (OR-PAM) is a novel imaging technology for visualizing optically absorbing superficial structures in vivo with lateral spatial resolution determined by optical focusing rather than acoustic detection. Since scanning of the illumination spot is required, OR-PAM imaging speed is limited by both scanning speed and laser pulse repetition rate. Unfortunately, lasers with high repetition rates and suitable pulse durations and energies are not widely available and can be cost-prohibitive and bulky. We are developing compact, passively Q-switched fiber and microchip laser sources for this application. The properties of these lasers are discussed, and pulse repetition rates up to 100 kHz are demonstrated. OR-PAM imaging was conducted using a previously developed photoacoustic probe, which enabled flexible scanning of the focused output of the lasers. Phantom studies demonstrate the ability to image with lateral spatial resolution of 7±2 μm with the microchip laser system and 15±5 μm with the fiber laser system. We believe that the high pulse repetition rates and the potentially compact and fiber-coupled nature of these lasers will prove important for clinical imaging applications where real-time imaging performance is essential.

Detecting and Imaging of γ-Glutamytranspeptidase Activity in Serum, Live Cells, and Pathological Tissues with a High Signal-Stability Probe by Releasing a Precipitating Fluorochrome.

PubMed

Ou-Yang, Juan; Li, Yong-Fei; Wu, Ping; Jiang, Wen-Li; Liu, Hong-Wen; Li, Chun-Yan

2018-06-20

γ-Glutamytranspeptidase (GGT) is a significant tumor-related biomarker that overexpresses in several tumor cells. Accurate detection and imaging of GGT activity in serum, live cells, and pathological tissues hold great significance for cancer diagnosis, treatment, and management. Recently developed small molecule fluorescent probes for GGT tend to diffuse to the whole cytoplasm and then translocate out of live cells after enzymatic reaction, which make them fail to provide high spatial resolution and long-term imaging in biological systems. To address these problems, a novel fluorescent probe (HPQ-PDG) which releases a precipitating fluorochrome upon the catalysis of GGT is designed and synthesized. HPQ-PDG is able to detect GGT activity with high spatial resolution and good signal-stability. The large Stokes shift of the probe enables it to detect the activity of GGT in serum samples with high sensitivity. To our delight, the probe is used for imaging GGT activity in live cells with the ability of discriminating cancer cells from normal cells. What's more, we successfully apply it for pathological tissues imaging, with the results indicating that the potential application of HPQ-PDG in histopathological examination. All these results demonstrate the potential application of HPQ-PDG in the clinic.

An optimized method for neurotransmitters and their metabolites analysis in mouse hypothalamus by high performance liquid chromatography-Q Exactive hybrid quadrupole-orbitrap high-resolution accurate mass spectrometry.

PubMed

Yang, Zong-Lin; Li, Hui; Wang, Bing; Liu, Shu-Ying

2016-02-15

Neurotransmitters (NTs) and their metabolites are known to play an essential role in maintaining various physiological functions in nervous system. However, there are many difficulties in the detection of NTs together with their metabolites in biological samples. A new method for NTs and their metabolites detection by high performance liquid chromatography coupled with Q Exactive hybrid quadruple-orbitrap high-resolution accurate mass spectrometry (HPLC-HRMS) was established in this paper. This method was a great development of the applying of Q Exactive MS in the quantitative analysis. This method enabled a rapid quantification of ten compounds within 18min. Good linearity was obtained with a correlation coefficient above 0.99. The concentration range of the limit of detection (LOD) and the limit of quantitation (LOQ) level were 0.0008-0.05nmol/mL and 0.002-25.0nmol/mL respectively. Precisions (relative standard deviation, RSD) of this method were at 0.36-12.70%. Recovery ranges were between 81.83% and 118.04%. Concentrations of these compounds in mouse hypothalamus were detected by Q Exactive LC-MS technology with this method. Copyright © 2016 Elsevier B.V. All rights reserved.

A plastic scintillator-based muon tomography system with an integrated muon spectrometer

NASA Astrophysics Data System (ADS)

Anghel, V.; Armitage, J.; Baig, F.; Boniface, K.; Boudjemline, K.; Bueno, J.; Charles, E.; Drouin, P.-L.; Erlandson, A.; Gallant, G.; Gazit, R.; Godin, D.; Golovko, V. V.; Howard, C.; Hydomako, R.; Jewett, C.; Jonkmans, G.; Liu, Z.; Robichaud, A.; Stocki, T. J.; Thompson, M.; Waller, D.

2015-10-01

A muon scattering tomography system which uses extruded plastic scintillator bars for muon tracking and a dedicated muon spectrometer that measures scattering through steel slabs has been constructed and successfully tested. The atmospheric muon detection efficiency is measured to be 97% per plane on average and the average intrinsic hit resolution is 2.5 mm. In addition to creating a variety of three-dimensional images of objects of interest, a quantitative study has been carried out to investigate the impact of including muon momentum measurements when attempting to detect high-density, high-Z material. As expected, the addition of momentum information improves the performance of the system. For a fixed data-taking time of 60 s and a fixed false positive fraction, the probability to detect a target increases when momentum information is used. This is the first demonstration of the use of muon momentum information from dedicated spectrometer measurements in muon scattering tomography.

Automated terrestrial laser scanning with near-real-time change detection - monitoring of the Séchilienne landslide

NASA Astrophysics Data System (ADS)

Kromer, Ryan A.; Abellán, Antonio; Hutchinson, D. Jean; Lato, Matt; Chanut, Marie-Aurelie; Dubois, Laurent; Jaboyedoff, Michel

2017-05-01

We present an automated terrestrial laser scanning (ATLS) system with automatic near-real-time change detection processing. The ATLS system was tested on the Séchilienne landslide in France for a 6-week period with data collected at 30 min intervals. The purpose of developing the system was to fill the gap of high-temporal-resolution TLS monitoring studies of earth surface processes and to offer a cost-effective, light, portable alternative to ground-based interferometric synthetic aperture radar (GB-InSAR) deformation monitoring. During the study, we detected the flux of talus, displacement of the landslide and pre-failure deformation of discrete rockfall events. Additionally, we found the ATLS system to be an effective tool in monitoring landslide and rockfall processes despite missing points due to poor atmospheric conditions or rainfall. Furthermore, such a system has the potential to help us better understand a wide variety of slope processes at high levels of temporal detail.

Ultrahigh-resolution optical coherence elastography through a micro-endoscope: towards in vivo imaging of cellular-scale mechanics

PubMed Central

Fang, Qi; Curatolo, Andrea; Wijesinghe, Philip; Yeow, Yen Ling; Hamzah, Juliana; Noble, Peter B.; Karnowski, Karol; Sampson, David D.; Ganss, Ruth; Kim, Jun Ki; Lee, Woei M.; Kennedy, Brendan F.

2017-01-01

In this paper, we describe a technique capable of visualizing mechanical properties at the cellular scale deep in living tissue, by incorporating a gradient-index (GRIN)-lens micro-endoscope into an ultrahigh-resolution optical coherence elastography system. The optical system, after the endoscope, has a lateral resolution of 1.6 µm and an axial resolution of 2.2 µm. Bessel beam illumination and Gaussian mode detection are used to provide an extended depth-of-field of 80 µm, which is a 4-fold improvement over a fully Gaussian beam case with the same lateral resolution. Using this system, we demonstrate quantitative elasticity imaging of a soft silicone phantom containing a stiff inclusion and a freshly excised malignant murine pancreatic tumor. We also demonstrate qualitative strain imaging below the tissue surface on in situ murine muscle. The approach we introduce here can provide high-quality extended-focus images through a micro-endoscope with potential to measure cellular-scale mechanics deep in tissue. We believe this tool is promising for studying biological processes and disease progression in vivo. PMID:29188108

High-resolution metabolomics assessment of military personnel: Evaluating analytical strategies for chemical detection

PubMed Central

Liu, Ken H.; Walker, Douglas I.; Uppal, Karan; Tran, ViLinh; Rohrbeck, Patricia; Mallon, Timothy M.; Jones, Dean P.

2016-01-01

Objective To maximize detection of serum metabolites with high-resolution metabolomics (HRM). Methods Department of Defense Serum Repository (DoDSR) samples were analyzed using ultra-high resolution mass spectrometry with three complementary chromatographic phases and four ionization modes. Chemical coverage was evaluated by number of ions detected and accurate mass matches to a human metabolomics database. Results Individual HRM platforms provided accurate mass matches for up to 58% of the KEGG metabolite database. Combining two analytical methods increased matches to 72%, and included metabolites in most major human metabolic pathways and chemical classes. Detection and feature quality varied by analytical configuration. Conclusions Dual chromatography HRM with positive and negative electrospray ionization provides an effective generalized method for metabolic assessment of military personnel. PMID:27501105

High-Resolution Gas Metering and Nonintrusive Appliance Load Monitoring System

NASA Astrophysics Data System (ADS)

Tewolde, Mahder

This thesis deals with design and implementation of a high-resolution metering system for residential natural gas meters. Detailed experimental measurements are performed on the meter to characterize and understand its measurement properties. Results from these experiments are used to develop a simple, fast and accurate technique to non-intrusively monitor the gas consumption of individual appliances in homes by resolving small amounts of gas usage. The technique is applied on an existing meter retrofitted with a module that includes a high-resolution encoder to collect gas flow data and a microprocessor to analyze and identify appliance load profiles. This approach provides a number of appealing features including low cost, easy installation and integration with automated meter reading (AMR) systems. The application of this method to residential gas meters currently deployed is also given. This is done by performing a load simulation on realistic gas loads with the aim of identifying the necessary parameters that minimize the cost and complexity of the mechanical encoder module. The primary benefits of the system are efficiency analysis, appliance health monitoring and real-time customer feedback of gas usage. Additional benefits of include the ability to detect very small leaks and theft. This system has the potential for wide scale market adoption.

Using a high spatial resolution tactile sensor for intention detection.

PubMed

Castellini, Claudio; Koiva, Risto

2013-06-01

Intention detection is the interpretation of biological signals with the aim of automatically, reliably and naturally understanding what a human subject desires to do. Although intention detection is not restricted to disabled people, such methods can be crucial in improving a patient's life, e.g., aiding control of a robotic wheelchair or of a self-powered prosthesis. Traditionally, intention detection is done using, e.g., gaze tracking, surface electromyography and electroencephalography. In this paper we present exciting initial results of an experiment aimed at intention detection using a high-spatial-resolution, high-dynamic-range tactile sensor. The tactile image of the ventral side of the forearm of 9 able-bodied participants was recorded during a variable-force task stimulated at the fingertip. Both the forces at the fingertip and at the forearm were synchronously recorded. We show that a standard dimensionality reduction technique (Principal Component Analysis) plus a Support Vector Machine attain almost perfect detection accuracy of the direction and the intensity of the intended force. This paves the way for high spatial resolution tactile sensors to be used as a means for intention detection.

Ultra-long high-sensitivity Φ-OTDR for high spatial resolution intrusion detection of pipelines.

PubMed

Peng, Fei; Wu, Han; Jia, Xin-Hong; Rao, Yun-Jiang; Wang, Zi-Nan; Peng, Zheng-Pu

2014-06-02

An ultra-long phase-sensitive optical time domain reflectometry (Φ-OTDR) that can achieve high-sensitivity intrusion detection over 131.5km fiber with high spatial resolution of 8m is presented, which is the longest Φ-OTDR reported to date, to the best of our knowledge. It is found that the combination of distributed Raman amplification with heterodyne detection can extend the sensing distance and enhances the sensitivity substantially, leading to the realization of ultra-long Φ-OTDR with high sensitivity and spatial resolution. Furthermore, the feasibility of applying such an ultra-long Φ-OTDR to pipeline security monitoring is demonstrated and the features of intrusion signal can be extracted with improved SNR by using the wavelet detrending/denoising method proposed.

Combined hostile fire and optics detection

NASA Astrophysics Data System (ADS)

Brännlund, Carl; Tidström, Jonas; Henriksson, Markus; Sjöqvist, Lars

2013-10-01

Snipers and other optically guided weapon systems are serious threats in military operations. We have studied a SWIR (Short Wave Infrared) camera-based system with capability to detect and locate snipers both before and after shot over a large field-of-view. The high frame rate SWIR-camera allows resolution of the temporal profile of muzzle flashes which is the infrared signature associated with the ejection of the bullet from the rifle. The capability to detect and discriminate sniper muzzle flashes with this system has been verified by FOI in earlier studies. In this work we have extended the system by adding a laser channel for optics detection. A laser diode with slit-shaped beam profile is scanned over the camera field-of-view to detect retro reflection from optical sights. The optics detection system has been tested at various distances up to 1.15 km showing the feasibility to detect rifle scopes in full daylight. The high speed camera gives the possibility to discriminate false alarms by analyzing the temporal data. The intensity variation, caused by atmospheric turbulence, enables discrimination of small sights from larger reflectors due to aperture averaging, although the targets only cover a single pixel. It is shown that optics detection can be integrated in combination with muzzle flash detection by adding a scanning rectangular laser slit. The overall optics detection capability by continuous surveillance of a relatively large field-of-view looks promising. This type of multifunctional system may become an important tool to detect snipers before and after shot.

High resolution in-operando microimaging of solar cells with pulsed electrically-detected magnetic resonance

NASA Astrophysics Data System (ADS)

Katz, Itai; Fehr, Matthias; Schnegg, Alexander; Lips, Klaus; Blank, Aharon

2015-02-01

The in-operando detection and high resolution spatial imaging of paramagnetic defects, impurities, and states becomes increasingly important for understanding loss mechanisms in solid-state electronic devices. Electron spin resonance (ESR), commonly employed for observing these species, cannot meet this challenge since it suffers from limited sensitivity and spatial resolution. An alternative and much more sensitive method, called electrically-detected magnetic resonance (EDMR), detects the species through their magnetic fingerprint, which can be traced in the device's electrical current. However, until now it could not obtain high resolution images in operating electronic devices. In this work, the first spatially-resolved electrically-detected magnetic resonance images (EDMRI) of paramagnetic states in an operating real-world electronic device are provided. The presented method is based on a novel microwave pulse sequence allowing for the coherent electrical detection of spin echoes in combination with powerful pulsed magnetic-field gradients. The applicability of the method is demonstrated on a device-grade 1-μm-thick amorphous silicon (a-Si:H) solar cell and an identical device that was degraded locally by an electron beam. The degraded areas with increased concentrations of paramagnetic defects lead to a local increase in recombination that is mapped by EDMRI with ∼20-μm-scale pixel resolution. The novel approach presented here can be widely used in the nondestructive in-operando three-dimensional characterization of solid-state electronic devices with a resolution potential of less than 100 nm.

Video-rate or high-precision: a flexible range imaging camera

NASA Astrophysics Data System (ADS)

Dorrington, Adrian A.; Cree, Michael J.; Carnegie, Dale A.; Payne, Andrew D.; Conroy, Richard M.; Godbaz, John P.; Jongenelen, Adrian P. P.

2008-02-01

A range imaging camera produces an output similar to a digital photograph, but every pixel in the image contains distance information as well as intensity. This is useful for measuring the shape, size and location of objects in a scene, hence is well suited to certain machine vision applications. Previously we demonstrated a heterodyne range imaging system operating in a relatively high resolution (512-by-512) pixels and high precision (0.4 mm best case) configuration, but with a slow measurement rate (one every 10 s). Although this high precision range imaging is useful for some applications, the low acquisition speed is limiting in many situations. The system's frame rate and length of acquisition is fully configurable in software, which means the measurement rate can be increased by compromising precision and image resolution. In this paper we demonstrate the flexibility of our range imaging system by showing examples of high precision ranging at slow acquisition speeds and video-rate ranging with reduced ranging precision and image resolution. We also show that the heterodyne approach and the use of more than four samples per beat cycle provides better linearity than the traditional homodyne quadrature detection approach. Finally, we comment on practical issues of frame rate and beat signal frequency selection.

Super-resolution imaging applied to moving object tracking

NASA Astrophysics Data System (ADS)

Swalaganata, Galandaru; Ratna Sulistyaningrum, Dwi; Setiyono, Budi

2017-10-01

Moving object tracking in a video is a method used to detect and analyze changes that occur in an object that being observed. Visual quality and the precision of the tracked target are highly wished in modern tracking system. The fact that the tracked object does not always seem clear causes the tracking result less precise. The reasons are low quality video, system noise, small object, and other factors. In order to improve the precision of the tracked object especially for small object, we propose a two step solution that integrates a super-resolution technique into tracking approach. First step is super-resolution imaging applied into frame sequences. This step was done by cropping the frame in several frame or all of frame. Second step is tracking the result of super-resolution images. Super-resolution image is a technique to obtain high-resolution images from low-resolution images. In this research single frame super-resolution technique is proposed for tracking approach. Single frame super-resolution was a kind of super-resolution that it has the advantage of fast computation time. The method used for tracking is Camshift. The advantages of Camshift was simple calculation based on HSV color that use its histogram for some condition and color of the object varies. The computational complexity and large memory requirements required for the implementation of super-resolution and tracking were reduced and the precision of the tracked target was good. Experiment showed that integrate a super-resolution imaging into tracking technique can track the object precisely with various background, shape changes of the object, and in a good light conditions.

Portable microscopy platform for the clinical and environmental monitoring

NASA Astrophysics Data System (ADS)

Wang, Weiming; Yu, Yan; Huang, Hui; Ou, Jinping

2016-04-01

Light microscopy can not only address various diagnosis needs such as aquatic parasites and bacteria such as E. coli in water, but also provide a method for the screening of red tide. Traditional microscope based on the smartphone created by adding lens couldn't keep the tradeoff between field-of-view(FOV) and the resolution. In this paper, we demonstrate a non-contact, light and cost-effective microscope platform, that can image highly dense samples with a spatial resolution of ~0.8um over a field-of-view(FOV) of >1mm2. After captured the direct images, we performed the pixel super-resolution algorithm to improve the image resolution and overcome the hardware interference. The system would be a good point-of-care diagnostic solution in resource limited settings. We validated the performance of the system by imaging resolution test targets, the squamous cell cancer(SqCC) and green algae that necessary to detect the squamous carcinoma and red tide

Competitive amplification of differentially melting amplicons (CADMA) enables sensitive and direct detection of all mutation types by high-resolution melting analysis.

PubMed

Kristensen, Lasse S; Andersen, Gitte B; Hager, Henrik; Hansen, Lise Lotte

2012-01-01

Sensitive and specific mutation detection is of particular importance in cancer diagnostics, prognostics, and individualized patient treatment. However, the majority of molecular methodologies that have been developed with the aim of increasing the sensitivity of mutation testing have drawbacks in terms of specificity, convenience, or costs. Here, we have established a new method, Competitive Amplification of Differentially Melting Amplicons (CADMA), which allows very sensitive and specific detection of all mutation types. The principle of the method is to amplify wild-type and mutated sequences simultaneously using a three-primer system. A mutation-specific primer is designed to introduce melting temperature decreasing mutations in the resulting mutated amplicon, while a second overlapping primer is designed to amplify both wild-type and mutated sequences. When combined with a third common primer very sensitive mutation detection becomes possible, when using high-resolution melting (HRM) as detection platform. The introduction of melting temperature decreasing mutations in the mutated amplicon also allows for further mutation enrichment by fast coamplification at lower denaturation temperature PCR (COLD-PCR). For proof-of-concept, we have designed CADMA assays for clinically relevant BRAF, EGFR, KRAS, and PIK3CA mutations, which are sensitive to, between 0.025% and 0.25%, mutated alleles in a wild-type background. In conclusion, CADMA enables highly sensitive and specific mutation detection by HRM analysis. © 2011 Wiley Periodicals, Inc.

Analytical strategies for controlling polysorbate-based nanomicelles in fruit juice.

PubMed

Krtkova, Veronika; Schulzova, Vera; Lacina, Ondrej; Hrbek, Vojtech; Tomaniova, Monika; Hajslova, Jana

2014-06-01

This study focused on the detection and quantification of organic micelle-type nanoparticles (NPs) with polysorbate components (polysorbate 20 and polysorbate 80) in their micelle shells that could be used to load biologically active compounds into fruit juice. Several advanced analytical techniques were applied in the stepwise method development strategy used. In the first phase, a system consisting of ultrahigh-performance liquid chromatography employing a size exclusion column coupled with an evaporative light scattering detector (UHPLC-SEC-ELSD) was used for the fractionation of micelle assemblies from other, lower molecular weight sample components. The limit of detection (LoD) of these polysorbate micelles in spiked apple juice was 500 μg mL(-1). After this screening step, mass spectrometric (MS) detection was utilized to confirm the presence of polysorbates in the detected micelles. Two alternative MS techniques were tested: (i) ambient high-resolution mass spectrometry employing a direct analysis in real time ion source coupled with an Orbitrap MS analyzer (DART-Orbitrap MS) enabled fast and simple detection of the polysorbates present in the samples, with a lowest calibration level (LCL) of 1000 μg mL(-1); (ii) ultrahigh-performance reversed-phase liquid chromatography coupled with high-resolution time-of-flight mass spectrometry (UHPLC-HRTOF-MS) provided highly selective and sensitive detection and quantification of polysorbates with an LCL of 0.5 μg mL(-1).

Compact and portable X-ray imager system using Medipix3RX

NASA Astrophysics Data System (ADS)

Garcia-Nathan, T. B.; Kachatkou, A.; Jiang, C.; Omar, D.; Marchal, J.; Changani, H.; Tartoni, N.; van Silfhout, R. G.

2017-10-01

In this paper the design and implementation of a novel portable X-ray imager system is presented. The design features a direct X-ray detection scheme by making use of a hybrid detector (Medipix3RX). Taking advantages of the capabilities of the Medipix3RX, like a high resolution, zero dead-time, single photon detection and charge-sharing mode, the imager has a better resolution and higher sensitivity compared to using traditional indirect detection schemes. A detailed description of the system is presented, which consists of a vacuum chamber containing the sensor, an electronic board for temperature management, conditioning and readout of the sensor and a data processing unit which also handles network connection and allow communication with clients by acting as a server. A field programmable gate array (FPGA) device is used to implement the readout protocol for the Medipix3RX, apart from the readout the FPGA can perform complex image processing functions such as feature extraction, histogram, profiling and image compression at high speeds. The temperature of the sensor is monitored and controlled through a PID algorithm making use of a Peltier cooler, improving the energy resolution and response stability of the sensor. Without implementing data compression techniques, the system is capable of transferring 680 profiles/s or 240 images/s in a continuous mode. Implementation of equalization procedures and tests on colour mode are presented in this paper. For the experimental measurements the Medipix3RX sensor was used with a Silicon layer. One of the tested applications of the system is as an X-ray beam position monitor (XBPM) device for synchrotron applications. The XBPM allows a non-destructive real time measurement of the beam position, size and intensity. A Kapton foil is placed in the beam path scattering radiation towards a pinhole camera setup that allows the sensor to obtain an image of the beam. By using profiles of the synchrotron X-ray beam, high frequency movement of the beam position can be studied, up to 340 Hz. The system is capable of realizing an independent energy measure of the beam by using the Medipix3RX variable energy threshold feature.

Subsurface Feature Mapping of Mars using a High Resolution Ground Penetrating Radar System

NASA Astrophysics Data System (ADS)

Wu, T. S.; Persaud, D. M.; Preudhomme, M. A.; Jurg, M.; Smith, M. K.; Buckley, H.; Tarnas, J.; Chalumeau, C.; Lombard-Poirot, N.; Mann, B.

2015-12-01

As the closest Earth-like, potentially life-sustaining planet in the solar system, Mars' future of human exploration is more a question of timing than possibility. The Martian surface remains hostile, but its subsurface geology holds promise for present or ancient astrobiology and future habitation, specifically lava tube (pyroduct) systems, whose presence has been confirmed by HiRISE imagery.The location and characterization of these systems could provide a basis for understanding the evolution of the red planet and long-term shelters for future manned missions on Mars. To detect and analyze the subsurface geology of terrestrial bodies from orbit, a novel compact (smallsat-scale) and cost-effective approach called the High-resolution Orbiter for Mapping gEology by Radar (HOMER) has been proposed. Adapting interferometry techniques with synthetic aperture radar (SAR) to a ground penetrating radar system, a small satellite constellation is able to achieve a theoretical resolution of 50m from low-Mars orbit (LMO). Alongside this initial prototype design of HOMER, proposed data processing methodology and software and a Mars mission design are presented. This project was developed as part of the 2015 NASA Ames Academy for Space Exploration.

Diffraction encoded position measuring apparatus

DOEpatents

Tansey, Richard J.

1991-01-01

When a lightwave passes through a transmission grating, diffracted beams appear at the output or opposite side of the grating that are effectively Doppler shifted in frequency (phase) whereby a detector system can compare the phase of the zero order and higher order beams to obtain an indication of position. Multiple passes through the grating increase resolution for a given wavelength of a laser signal. The resolution can be improved further by using a smaller wavelength laser to generate the grating itself. Since the grating must only have a pitch sufficient to produce diffracted orders, inexpensive, ultraviolet wavelength lasers can be utilized and still obtain high resolution detection.

Diffraction encoded position measuring apparatus

DOEpatents

Tansey, R.J.

1991-09-24

When a lightwave passes through a transmission grating, diffracted beams appear at the output or opposite side of the grating that are effectively Doppler shifted in frequency (phase) whereby a detector system can compare the phase of the zero order and higher order beams to obtain an indication of position. Multiple passes through the grating increase resolution for a given wavelength of a laser signal. The resolution can be improved further by using a smaller wavelength laser to generate the grating itself. Since the grating must only have a pitch sufficient to produce diffracted orders, inexpensive, ultraviolet wavelength lasers can be utilized and still obtain high resolution detection. 3 figures.

Atomic magnetometer-based ultra-sensitive magnetic microscopy

NASA Astrophysics Data System (ADS)

Kim, Young Jin; Savukov, Igor

2016-03-01

An atomic magnetometer (AM) based on lasers and alkali-metal vapor cells is currently the most sensitive non-cryogenic magnetic-field sensor. Many applications in neuroscience and other fields require high resolution, high sensitivity magnetic microscopic measurements. In order to meet this need we combined a cm-size spin-exchange relaxation-free AM with a flux guide (FG) to produce an ultra-sensitive FG-AM magnetic microscope. The FG serves to transmit the target magnetic flux to the AM thus enhancing both the sensitivity and resolution for tiny magnetic objects. In this talk, we will describe a prototype FG-AM device and present experimental and numerical tests of its sensitivity and resolution. We also demonstrate that an optimized FG-AM achieves high resolution and high sensitivity sufficient to detect a magnetic field of a single neuron in a few seconds, which would be an important milestone in neuroscience. We anticipate that this unique device can be applied to the detection of a single neuron, the detection of magnetic nano-particles, which in turn are very important for detection of target molecules in national security and medical diagnostics, and non-destructive testing.

A hybrid thermal video and FTIR spectrometer system for rapidly locating and characterizing gas leaks

NASA Astrophysics Data System (ADS)

Williams, David J.; Wadsworth, Winthrop; Salvaggio, Carl; Messinger, David W.

2006-08-01

Undiscovered gas leaks, known as fugitive emissions, in chemical plants and refinery operations can impact regional air quality and present a loss of product for industry. Surveying a facility for potential gas leaks can be a daunting task. Industrial leak detection and repair programs can be expensive to administer. An efficient, accurate and cost effective method for detecting and quantifying gas leaks would both save industries money by identifying production losses and improve regional air quality. Specialized thermal video systems have proven effective in rapidly locating gas leaks. These systems, however, do not have the spectral resolution for compound identification. Passive FTIR spectrometers can be used for gas compound identification, but using these systems for facility surveys is problematic due to their small field of view. A hybrid approach has been developed that utilizes the thermal video system to locate gas plumes using real time visualization of the leaks, coupled with the high spectral resolution FTIR spectrometer for compound identification and quantification. The prototype hybrid video/spectrometer system uses a sterling cooled thermal camera, operating in the MWIR (3-5 μm) with an additional notch filter set at around 3.4 μm, which allows for the visualization of gas compounds that absorb in this narrow spectral range, such as alkane hydrocarbons. This camera is positioned alongside of a portable, high speed passive FTIR spectrometer, which has a spectral range of 2 - 25 μm and operates at 4 cm -1 resolution. This system uses a 10 cm telescope foreoptic with an onboard blackbody for calibration. The two units are optically aligned using a turning mirror on the spectrometer's telescope with the video camera's output.

High Resolution Eddy-Current Wire Testing Based on a Gmr Sensor-Array

NASA Astrophysics Data System (ADS)

Kreutzbruck, Marc; Allweins, Kai; Strackbein, Chris; Bernau, Hendrick

2009-03-01

Increasing demands in materials quality and cost effectiveness have led to advanced standards in manufacturing technology. Especially when dealing with high quality standards in conjunction with high throughput quantitative NDE techniques are vital to provide reliable and fast quality control systems. In this work we illuminate a modern electromagnetic NDE approach using a small GMR sensor array for testing superconducting wires. Four GMR sensors are positioned around the wire. Each GMR sensor provides a field sensitivity of 200 pT/√Hz and a spatial resolution of about 100 μm. This enables us to detect under surface defects of 100 μm in size in a depth of 200 μm with a signal-to-noise ratio of better than 400. Surface defects could be detected with a SNR of up to 10,000. Besides this remarkably SNR the small extent of GMR sensors results in a spatial resolution which offers new visualisation techniques for defect localisation, defect characterization and tomography-like mapping techniques. We also report on inverse algorithms based on either a Finite Element Method or an analytical approach. These allow for accurate defect localization on the urn scale and an estimation of the defect size.

In vivo flow cytometry for blood cell analysis using differential epi-detection of forward scattered light

NASA Astrophysics Data System (ADS)

Paudel, Hari P.; Jung, Yookyung; Raphael, Anthony; Alt, Clemens; Wu, Juwell; Runnels, Judith; Lin, Charles P.

2018-02-01

The present standard of blood cell analysis is an invasive procedure requiring the extraction of patient's blood, followed by ex-vivo analysis using a flow cytometer or a hemocytometer. We are developing a noninvasive optical technique that alleviates the need for blood extraction. For in-vivo blood analysis we need a high speed, high resolution and high contrast label-free imaging technique. In this proceeding report, we reported a label-free method based on differential epi-detection of forward scattered light, a method inspired by Jerome Mertz's oblique back-illumination microscopy (OBM) (Ford et al, Nat. Meth. 9(12) 2012). The differential epi-detection of forward light gives phase contrast image at diffraction-limited resolution. Unlike reflection confocal microscopy (RCM), which detects only sharp refractive index variation and suffers from speckle noise, this technique is suitable for detection of subtle variation of refractive index in biological tissue and it provides the shape and the size of cells. A custom built high speed electronic detection circuit board produces a real-time differential signal which yields image contrast based on phase gradient in the sample. We recorded blood flow in-vivo at 17.2k lines per second in line scan mode, or 30 frames per second (full frame), or 120 frame per second (quarter frame) in frame scan mode. The image contrast and speed of line scan data recording show the potential of the system for noninvasive blood cell analysis.

A high resolution ultraviolet Shuttle glow spectrograph

NASA Technical Reports Server (NTRS)

Carruthers, George R.

1993-01-01

The High Resolution Shuttle Glow Spectrograph-B (HRSGS-B) is a small payload being developed by the Naval Research Laboratory. It is intended for study of shuttle surface glow in the 180-400 nm near- and middle-ultraviolet wavelength range, with a spectral resolution of 0.2 nm. It will search for, among other possible features, the band systems of excited NO which result from surface-catalyzed combination of N and O. It may also detect O2 Hertzberg bands and N2 Vegard-Kaplan bands resulting from surface recombination. This wavelength range also includes possible N2+ and OH emissions. The HRSGS-B will be housed in a Get Away Special canister, mounted in the shuttle orbiter payload bay, and will observe the glow on the tail of the orbiter.

Eccentricity in planetary systems and the role of binarity. Sample definition, initial results, and the system of HD 211847

NASA Astrophysics Data System (ADS)

Moutou, C.; Vigan, A.; Mesa, D.; Desidera, S.; Thébault, P.; Zurlo, A.; Salter, G.

2017-06-01

We explore the multiplicity of exoplanet host stars with high-resolution images obtained with VLT/SPHERE. Two different samples of systems were observed: one containing low-eccentricity outer planets, and the other containing high-eccentricity outer planets. We find that 10 out of 34 stars in the high-eccentricity systems are members of a binary, while the proportion is 3 out of 27 for circular systems. Eccentric-exoplanet hosts are, therefore, significantly more likely to have a stellar companion than circular-exoplanet hosts. The median magnitude contrast over the 68 data sets is 11.26 and 9.25, in H and K, respectively, at 0.30 arcsec. The derived detection limits reveal that binaries with separations of less than 50 au are rarer for exoplanet hosts than for field stars. Our results also imply that the majority of high-eccentricity planets are not embedded in multiple stellar systems (24 out of 34), since our detection limits exclude the presence of a stellar companion. We detect the low-mass stellar companions of HD 7449 and HD 211847, both members of our high-eccentricity sample. HD 7449B was already detected and our independent observation is in agreement with this earlier work. HD 211847's substellar companion, previously detected by the radial velocity method, is actually a low-mass star seen face-on. The role of stellar multiplicity in shaping planetary systems is confirmed by this work, although it does not appear as the only source of dynamical excitation. Based on observations collected with SPHERE on the Very Large Telescope (ESO, Chile).

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xu, Fan; Wang, Yuanqing, E-mail: yqwang@nju.edu.cn; Li, Fenfang

The avalanche-photodiode-array (APD-array) laser detection and ranging (LADAR) system has been continually developed owing to its superiority of nonscanning, large field of view, high sensitivity, and high precision. However, how to achieve higher-efficient detection and better integration of the LADAR system for real-time three-dimensional (3D) imaging continues to be a problem. In this study, a novel LADAR system using four linear mode APDs (LmAPDs) is developed for high-efficient detection by adopting a modulation and multiplexing technique. Furthermore, an automatic control system for the array LADAR system is proposed and designed by applying the virtual instrumentation technique. The control system aimsmore » to achieve four functions: synchronization of laser emission and rotating platform, multi-channel synchronous data acquisition, real-time Ethernet upper monitoring, and real-time signal processing and 3D visualization. The structure and principle of the complete system are described in the paper. The experimental results demonstrate that the LADAR system is capable of achieving real-time 3D imaging on an omnidirectional rotating platform under the control of the virtual instrumentation system. The automatic imaging LADAR system utilized only 4 LmAPDs to achieve 256-pixel-per-frame detection with by employing 64-bit demodulator. Moreover, the lateral resolution is ∼15 cm and range accuracy is ∼4 cm root-mean-square error at a distance of ∼40 m.« less

Arrays of Segmented, Tapered Light Guides for Use With Large, Planar Scintillation Detectors

NASA Astrophysics Data System (ADS)

Raylman, Raymond R.; Vaigneur, Keith; Stolin, Alexander V.; Jaliparthi, Gangadhar

2015-06-01

Metabolic imaging techniques can potentially improve detection and diagnosis of cancer in women with radiodense and/or fibrocystic breasts. Our group has previously developed a high-resolution positron emission tomography imaging and biopsy device (PEM-PET) to detect and guide the biopsy of suspicious breast lesions. Initial testing revealed that the imaging field-of-view (FOV) of the scanner was smaller than the physical size of the detector's active area, which could hinder sampling of breast areas close to the chest wall. The purpose of this work was to utilize segmented, tapered light guides for optically coupling the scintillator arrays to arrays of position-sensitive photomultipliers to increase both the active FOV and identification of individual scintillator elements. Testing of the new system revealed that the optics of these structures made it possible to discern detector elements from the complete active area of the detector face. In the previous system the top and bottom rows and left and right columns were not identifiable. Additionally, use of the new light guides increased the contrast of individual detector elements by up to 129%. Improved element identification led to a spatial resolution increase by approximately 12%. Due to attenuation of light in the light guides the detector energy resolution decreased from 18.5% to 19.1%. Overall, these improvements should increase the field-of-view and spatial resolution of the dedicated breast-PET system.

Fabrication and characterization of a 0.5-mm lutetium oxyorthosilicate detector array for high-resolution PET applications.

PubMed

Stickel, Jennifer R; Qi, Jinyi; Cherry, Simon R

2007-01-01

With the increasing use of in vivo imaging in mouse models of disease, there are many interesting applications that demand imaging of organs and tissues with submillimeter resolution. Though there are other contributing factors, the spatial resolution in small-animal PET is still largely determined by the detector pixel dimensions. In this work, a pair of lutetium oxyorthosilicate (LSO) arrays with 0.5-mm pixels was coupled to multichannel photomultiplier tubes and evaluated for use as high-resolution PET detectors. Flood histograms demonstrated that most crystals were clearly identifiable. Energy resolution varied from 22% to 38%. The coincidence timing resolution was 1.42-ns full width at half maximum (FWHM). The intrinsic spatial resolution was 0.68-mm FWHM as measured with a 30-gauge needle filled with (18)F. The improvement in spatial resolution in a tomographic setting is demonstrated using images of a line source phantom reconstructed with filtered backprojection and compared with images obtained from 2 dedicated small-animal PET scanners. Finally, a projection image of the mouse foot is shown to demonstrate the application of these 0.5-mm LSO detectors to a biologic task. A pair of highly pixelated LSO detections has been constructed and characterized for use as high-spatial-resolution PET detectors. It appears that small-animal PET systems capable of a FWHM spatial resolution of 600 microm or less are feasible and should be pursued.

Further developments of series-connected superconducting tunnel junction to radiation detection

NASA Astrophysics Data System (ADS)

Kurakado, Masahiko; Ohsawa, Daisuke; Katano, Rintaro; Ito, Shin; Isozumi, Yasuhito

1997-10-01

One of the promising radiation detection devices for various practical applications is the series-connected superconducting tunnel junction (STJ) detector. In this article, interesting topics of the detectors are described since our previous work: e.g., more than two order higher detection efficiency compared with single STJ detectors, high count rate detection, and position resolution. Detectors were cooled to 0.35-0.4 K by means of a convenient 3He cryostat. The 5.9 and 6.5 keV x rays from 55Fe are separated by a detector specially designed for x-ray detection. The possible count rate of the series-junction detector estimated from the shaping-time constant applied in the measurements is high, e.g., over 104 counts per second. A series-junction detector equipped with a position sensing mechanism has shown a position resolution of about 35 μm in a sensing area with a radius of 1.1 mm. The position resolution of series junctions improves the energy resolution. A new type series-connected STJ detector is also proposed, i.e., the dispersed multitrap series-junction detector, for further improvement of detection efficiency and energy resolution.

An Integrated System for Superharmonic Contrast-Enhanced Ultrasound Imaging: Design and Intravascular Phantom Imaging Study.

PubMed

Li, Yang; Ma, Jianguo; Martin, K Heath; Yu, Mingyue; Ma, Teng; Dayton, Paul A; Jiang, Xiaoning; Shung, K Kirk; Zhou, Qifa

2016-09-01

Superharmonic contrast-enhanced ultrasound imaging, also called acoustic angiography, has previously been used for the imaging of microvasculature. This approach excites microbubble contrast agents near their resonance frequency and receives echoes at nonoverlapping superharmonic bandwidths. No integrated system currently exists could fully support this application. To fulfill this need, an integrated dual-channel transmit/receive system for superharmonic imaging was designed, built, and characterized experimentally. The system was uniquely designed for superharmonic imaging and high-resolution B-mode imaging. A complete ultrasound system including a pulse generator, a data acquisition unit, and a signal processing unit were integrated into a single package. The system was controlled by a field-programmable gate array, on which multiple user-defined modes were implemented. A 6-, 35-MHz dual-frequency dual-element intravascular ultrasound transducer was designed and used for imaging. The system successfully obtained high-resolution B-mode images of coronary artery ex vivo with 45-dB dynamic range. The system was capable of acquiring in vitro superharmonic images of a vasa vasorum mimicking phantom with 30-dB contrast. It could detect a contrast agent filled tissue mimicking tube of 200 μm diameter. For the first time, high-resolution B-mode images and superharmonic images were obtained in an intravascular phantom, made possible by the dedicated integrated system proposed. The system greatly reduced the cost and complexity of the superharmonic imaging intended for preclinical study. Significant: The system showed promise for high-contrast intravascular microvascular imaging, which may have significant importance in assessment of the vasa vasorum associated with atherosclerotic plaques.

Three-dimensional rotational micro-angiography

NASA Astrophysics Data System (ADS)

Patel, Vikas

Computed tomography (CT) is state-of-the-art for 3D imaging in which images are acquired about the patient and are used to reconstruct the data. But the commercial CT systems suffer from low spatial resolution (0.5-2 lp/mm). Micro-CT (microCT) systems have high resolution 3D reconstruction (>10 lp/mm), but are currently limited to small objects, e.g., small animals. To achieve artifact free reconstructions, geometric calibration of the rotating-object cone-beam microCT (CBmicroCT) system is performed using new techniques that use only the projection images of the object, i.e., no calibration objects are required. Translations (up to 0.2 mm) occurring during the acquisition in the horizontal direction are detected, quantified, and corrected based on sinogram analysis. The parameters describing the physical axis of rotation determined using our image-based method (aligning anti-posed images) agree well (within 0.1 mm and 0.3 degrees) with those determined using other techniques that use calibration objects. Geometric calibrations of the rotational angiography (RA) systems (clinical cone-beam CT systems with fluoroscopic capabilities provided by flat-panel detectors (FPD)) are performed using a simple single projection technique (SPT), which aligns a known 3D model of a calibration phantom with the projection data. The calibration parameters obtained by the SPT are found to be reproducible (angles within 0.2° and x- and y-translations less than 2 mm) for over 7 months. The spatial resolution of the RA systems is found to be virtually unaffected by such small geometric variations. Finally, using our understanding of the geometric calibrations, we have developed methods to combine relatively low-resolution RA acquisitions (2-3 lp/mm) with high resolution microCT acquisitions (using a high-resolution micro-angiographic fluoroscope (MAF) attached to the RA gantry) to produce the first-ever 3D rotational micro-angiography (3D-RmicroA) system on a clinical gantry. Images of a rabbit with a coronary stent placed in an artery were obtained and reconstructed. To eliminate artifacts due to image truncation, lower-dose (compared to the MAF acquisition) full-FOV (FFOV) FPD RA sequences are also obtained. To ensure high-quality high-resolution reconstruction, the high-resolution images from the MAF are aligned spatially with the lower-dose FPD images (average correlation coefficient before and after alignment: 0.65 and 0.97 respectively), and the pixel values in the FPD image data are scaled (using linear regression) to match those of the MAF. Greater details without any visible truncation artifacts are seen in 3D RmicroA (MAF-FPD) images than in those of the FPD alone. The FWHM of line profiles of stent struts (100 micron diameter) are approximately 192 +/- 21 and 313 +/- 38 microns for the 3D RmicroA and FPD data, respectively. Thus, with the RmicroA system, we have essentially developed a high resolution CBmicroCT system for clinical use.

High-speed Raman-encoded molecular imaging of freshly excised tissue surfaces with topically applied SERRS nanoparticles

NASA Astrophysics Data System (ADS)

Wang, Yu "Winston"; Yang, Qian; Kang, Soyoung; Wall, Matthew A.; Liu, Jonathan T. C.

2018-04-01

Surface-enhanced Raman scattering (SERS) nanoparticles (NPs) are increasingly being engineered for a variety of disease-detection and treatment applications. For example, we have previously developed a fiber-optic Raman-encoded molecular imaging (REMI) system for spectral imaging of biomarker-targeted SERS NPs topically applied on tissue surfaces to identify residual tumors at surgical margins. Although accurate tumor detection was achieved, the commercial SERS NPs used in our previous studies lacked the signal strength to enable high-speed imaging with high pixel counts (large fields of view and/or high spatial resolution), which limits their use for certain time-constrained clinical applications. As a solution, we explored the use of surface-enhanced resonant Raman scattering (SERRS) NPs to enhance imaging speeds. The SERRS NPs were synthesized de novo, and then conjugated to HER2 antibodies to achieve high binding affinity, as validated by flow cytometry. Under identical tissue-staining and imaging conditions, the targeted SERRS NPs enabled reliable identification of HER2-overexpressed tumor xenografts with 50-fold-enhanced imaging speed compared with our standard targeted SERS NPs. This enables our REMI system to image tissue surfaces at a rate of 150 cm2 per minute at a spatial resolution of 0.5 mm.

Sub-micron materials characterization using near-field optics

NASA Astrophysics Data System (ADS)

Blodgett, David Wesley

1998-12-01

High-resolution sub-surface materials characterization and inspection are critical in the microelectronics and thin films industries. To this end, a technique is described that couples the bulk property measurement capabilities of high-frequency ultrasound with the high-resolution surface imaging capabilities of the near-field optical microscope. Sensing bulk microstructure variations in the material, such as grain boundaries, requires a detection footprint smaller than the variation itself. The near-field optical microscope, with the ability to exceed the diffraction limit in optical resolution, meets this requirement. Two apertureless near-field optical microscopes, on-axis and off-axis illumination, have been designed and built. Near-field and far-field approach curves for both microscopes are presented. The sensitivity of the near-field approach curve was 8.3 muV/nm. Resolution studies for the near-field microscope indicate optical resolutions on the order of 50 nm, which exceeds the diffraction limit. The near-field microscope has been adapted to detect both contact-transducer-generated and laser-generated ultrasound. The successful detection of high-frequency ultrasound with the near-field optical microscope demonstrates the potential of this technique.

FERMI: a digital Front End and Readout MIcrosystem for high resolution calorimetry

NASA Astrophysics Data System (ADS)

Alexanian, H.; Appelquist, G.; Bailly, P.; Benetta, R.; Berglund, S.; Bezamat, J.; Blouzon, F.; Bohm, C.; Breveglieri, L.; Brigati, S.; Cattaneo, P. W.; Dadda, L.; David, J.; Engström, M.; Genat, J. F.; Givoletti, M.; Goggi, V. G.; Gong, S.; Grieco, G. M.; Hansen, M.; Hentzell, H.; Holmberg, T.; Höglund, I.; Inkinen, S. J.; Kerek, A.; Landi, C.; Ledortz, O.; Lippi, M.; Lofstedt, B.; Lund-Jensen, B.; Maloberti, F.; Mutz, S.; Nayman, P.; Piuri, V.; Polesello, G.; Sami, M.; Savoy-Navarro, A.; Schwemling, P.; Stefanelli, R.; Sundblad, R.; Svensson, C.; Torelli, G.; Vanuxem, J. P.; Yamdagni, N.; Yuan, J.; Ödmark, A.; Fermi Collaboration

1995-02-01

We present a digital solution for the front-end electronics of high resolution calorimeters at future colliders. It is based on analogue signal compression, high speed {A}/{D} converters, a fully programmable pipeline and a digital signal processing (DSP) chain with local intelligence and system supervision. This digital solution is aimed at providing maximal front-end processing power by performing waveform analysis using DSP methods. For the system integration of the multichannel device a multi-chip, silicon-on-silicon multi-chip module (MCM) has been adopted. This solution allows a high level of integration of complex analogue and digital functions, with excellent flexibility in mixing technologies for the different functional blocks. This type of multichip integration provides a high degree of reliability and programmability at both the function and the system level, with the additional possibility of customising the microsystem to detector-specific requirements. For enhanced reliability in high radiation environments, fault tolerance strategies, i.e. redundancy, reconfigurability, majority voting and coding for error detection and correction, are integrated into the design.

High resolution biomedical imaging system with direct detection of x-rays via a charge coupled device

DOEpatents

Atac, M.; McKay, T.A.

1998-04-21

An imaging system is provided for direct detection of x-rays from an irradiated biological tissue. The imaging system includes an energy source for emitting x-rays toward the biological tissue and a charge coupled device (CCD) located immediately adjacent the biological tissue and arranged transverse to the direction of irradiation along which the x-rays travel. The CCD directly receives and detects the x-rays after passing through the biological tissue. The CCD is divided into a matrix of cells, each of which individually stores a count of x-rays directly detected by the cell. The imaging system further includes a pattern generator electrically coupled to the CCD for reading a count from each cell. A display device is provided for displaying an image representative of the count read by the pattern generator from the cells of the CCD. 13 figs.

High resolution biomedical imaging system with direct detection of x-rays via a charge coupled device

DOEpatents

Atac, Muzaffer; McKay, Timothy A.

1998-01-01

An imaging system is provided for direct detection of x-rays from an irradiated biological tissue. The imaging system includes an energy source for emitting x-rays toward the biological tissue and a charge coupled device (CCD) located immediately adjacent the biological tissue and arranged transverse to the direction of irradiation along which the x-rays travel. The CCD directly receives and detects the x-rays after passing through the biological tissue. The CCD is divided into a matrix of cells, each of which individually stores a count of x-rays directly detected by the cell. The imaging system further includes a pattern generator electrically coupled to the CCD for reading a count from each cell. A display device is provided for displaying an image representative of the count read by the pattern generator from the cells of the CCD.

Robo-AO Kepler Survey. IV. The Effect of Nearby Stars on 3857 Planetary Candidate Systems

NASA Astrophysics Data System (ADS)

Ziegler, Carl; Law, Nicholas M.; Baranec, Christoph; Riddle, Reed; Duev, Dmitry A.; Howard, Ward; Jensen-Clem, Rebecca; Kulkarni, S. R.; Morton, Tim; Salama, Maïssa

2018-04-01

We present the overall statistical results from the Robo-AO Kepler planetary candidate survey, comprising of 3857 high-angular resolution observations of planetary candidate systems with Robo-AO, an automated laser adaptive optics system. These observations reveal previously unknown nearby stars blended with the planetary candidate host stars that alter the derived planetary radii or may be the source of an astrophysical false positive transit signal. In the first three papers in the survey, we detected 440 nearby stars around 3313 planetary candidate host stars. In this paper, we present observations of 532 planetary candidate host stars, detecting 94 companions around 88 stars; 84 of these companions have not previously been observed in high resolution. We also report 50 more-widely separated companions near 715 targets previously observed by Robo-AO. We derive corrected planetary radius estimates for the 814 planetary candidates in systems with a detected nearby star. If planetary candidates are equally likely to orbit the primary or secondary star, the radius estimates for planetary candidates in systems with likely bound nearby stars increase by a factor of 1.54, on average. We find that 35 previously believed rocky planet candidates are likely not rocky due to the presence of nearby stars. From the combined data sets from the complete Robo-AO KOI survey, we find that 14.5 ± 0.5% of planetary candidate hosts have a nearby star with 4″, while 1.2% have two nearby stars, and 0.08% have three. We find that 16% of Earth-sized, 13% of Neptune-sized, 14% of Saturn-sized, and 19% of Jupiter-sized planet candidates have detected nearby stars.

Development of an optical inspection platform for surface defect detection in touch panel glass

NASA Astrophysics Data System (ADS)

Chang, Ming; Chen, Bo-Cheng; Gabayno, Jacque Lynn; Chen, Ming-Fu

2016-04-01

An optical inspection platform combining parallel image processing with high resolution opto-mechanical module was developed for defect inspection of touch panel glass. Dark field images were acquired using a 12288-pixel line CCD camera with 3.5 µm per pixel resolution and 12 kHz line rate. Key features of the glass surface were analyzed by parallel image processing on combined CPU and GPU platforms. Defect inspection of touch panel glass, which provided 386 megapixel image data per sample, was completed in roughly 5 seconds. High detection rate of surface scratches on the touch panel glass was realized with minimum defects size of about 10 µm after inspection. The implementation of a custom illumination source significantly improved the scattering efficiency on the surface, therefore enhancing the contrast in the acquired images and overall performance of the inspection system.

Spectroscopy of bright Algol-type semi-detached close binary system HU Tauri (HR 1471)

NASA Astrophysics Data System (ADS)

Parthasarathy, M.

2018-01-01

Radial velocities of the primary component (B8V) of HU Tauri derived from the photographic spectra obtained during January 1974 to December 1974 and spectroscopic orbital elements from the analysis of the radial velocity curve of the B8V primary are given. The H line of the late type secondary component is clearly detected on the photographic spectra taken around the quadratures and radial velocities of the secondary component are derived. The radial velocity semi amplitudes of the primary (K) and secondary (K) are found to be 60 km/sec and 234 km/sec respectively. The mass ratio M/M = K/K is found to be 0.2564. The detection of the H line of the secondary is confirmed from the high resolution spectra that I obtained during 1981 and 1983 at quadratures using the 2.1-m McDonald observatory Otto Struve reflector telescope and high resolution coude Reticon spectrograph.

A Multi-Contact, Low Capacitance HPGe Detector for High Rate Gamma Spectroscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cox, Christopher

2014-12-04

The detection, identification and non-destructive assay of special nuclear materials and nuclear fission by-products are critically important activities in support of nuclear non-proliferation programs. Both national and international nuclear safeguard agencies recognize that current accounting methods for spent nuclear fuel are inadequate from a safeguards perspective. Radiation detection and analysis by gamma-ray spectroscopy is a key tool in this field, but no instrument exists that can deliver the required performance (energy resolution and detection sensitivity) in the presence of very high background count rates encountered in the nuclear safeguards arena. The work of this project addresses this critical need bymore » developing a unique gamma-ray detector based on high purity germanium that has the previously unachievable property of operating in the 1 million counts-per-second range while achieving state-of-the-art energy resolution necessary to identify and analyze the isotopes of interest. The technical approach was to design and fabricate a germanium detector with multiple segmented electrodes coupled to multi-channel high rate spectroscopy electronics. Dividing the germanium detector’s signal electrode into smaller sections offers two advantages; firstly, the energy resolution of the detector is potentially improved, and secondly, the detector is able to operate at higher count rates. The design challenges included the following; determining the optimum electrode configuration to meet the stringent energy resolution and count rate requirements; determining the electronic noise (and therefore energy resolution) of the completed system after multiple signals are recombined; designing the germanium crystal housing and vacuum cryostat; and customizing electronics to perform the signal recombination function in real time. In this phase I work, commercial off-the-shelf electrostatic modeling software was used to develop the segmented germanium crystal geometry, which underwent several iterations before an optimal electrode configuration was found. The model was tested and validated against real-world measurements with existing germanium detectors. Extensive modeling of electronic noise was conducted using established formulae, and real-world measurements were performed on candidate front-end electronic components. This initial work proved the feasibility of the design with respect to expected high count rate and energy resolution performance. Phase I also delivered the mechanical design of the detector housing and vacuum cryostat to be built in Phase II. Finally, a Monte Carlo simulation was created to show the response of the complete design to a Cs-137 source. This development presents a significant advance for nuclear safeguards instrumentation with increased speed and accuracy of detection and identification of special nuclear materials. Other significant applications are foreseen for a gamma-ray detector that delivers high energy resolution (1keV FWHM noise) at high count rate (1 Mcps), especially in the areas of physics research and materials analysis.« less

Near-Infrared high resolution spectral survey of comets with GIANO/TNG: The CN red-system at 1.1 μm

NASA Astrophysics Data System (ADS)

Faggi, Sara; Villanueva, Geronimo Luis; Mumma, Michael J.; Tozzi, Gian-Paolo; Brucato, John Robert

2016-10-01

High-resolution spectroscopy in the near-infrared spectral range is a powerful tool to investigate chemical composition and isotopic fractionation.Comets are the best preserved relic of the enfant stages of the solar system. By targeting biologically relevant species in cometary comae and retrieving isotopic (e.g. D/H) and spin isomeric (e.g., ortho- and para- water) ratios, we can study the formation and evolution of solar system matter, address the origin of Earth's oceans and characterize the delivery of organic matter that was essential for the appearance of life on early Earth. We initiated the first high resolution spectral survey of comets ever conducted in the 0.9-2.5 μm range, targeting C/2014 Q2 (Lovejoy), C/2013 US10 (Catalina) and C/2013 X1 (Panstarrs) with GIANO - the near-IR high resolution spectrograph on Telescopio Nazionale Galileo (TNG). In comet Lovejoy, we detected eight ro-vibrational bands of H2O (Faggi et al., 2016, ApJ in press), emission from the red-system of CN, and many other emission lines whose precursors are now being identified. In this talk we will present a new quantum mechanical solar fluorescence model for the CN red system and the retrievals obtained with it from our cometary spectra. These observations open new pathways for cometary science in the near-infrared spectral range (0.9-2.5 μm) and establish the feasibility of astrobiology-related scientific investigations with future high resolution IR spectrographs on 30-m class telescopes, e.g., the HIRES spectrograph on the E-ELT telescope. This work is part of Sara Faggi's Ph.D. thesis project. NASA's Planetary Astronomy Program supported GLV and MJM through funding awarded under proposal 11-PAST11-0045 (M. J. Mumma, PI ).

Calibration of the Verification Engineering Test Article-I (VETA-I) for AXAF using the VETA-I X-ray Detection System

NASA Technical Reports Server (NTRS)

Kellogg, E.; Brissenden, R.; Flanagan, K.; Freeman, M.; Hughes, J.; Jones, M.; Ljungberg, M.; Mckinnon, P.; Podgorski, W.; Schwartz, D.

1992-01-01

Advanced X-ray Astrophysics Facility (AXAF) X-ray optics testing is conducted by VETA-I, which consists of six nested Wolter type I grazing-incidence mirrors; VETA's X-ray Detection System (VXDS) in turn measures the imaging properties of VETA-I, yielding FWHM and encircled energy of the X-ray image obtained, as well as its effective area. VXDS contains a high resolution microchannel plate imaging X-ray detector and a pinhole scanning system in front of proportional-counter detectors. VETA-I's X-ray optics departs from the AXAF flight configuration in that it uses a temporary holding fixture; its mirror elements are not cut to final length, and are not coated with the metal film used to maximize high-energy reflection.

Optical Fiber On-Line Detection System for Non-Touch Monitoring Roller Shape

NASA Astrophysics Data System (ADS)

Guo, Y.; Wang, Y. T.

2006-10-01

Basing on the principle of reflective displacement fiber-optic sensor, a high accuracy non-touch on-line optical fiber measurement system for roller shape is presented. The principle and composition of the detection system and the operation process are expatiated also. By using a novel probe of three optical fibers in equal transverse space, the effects of fluctuations in the light source, reflective changing of target surface and the intensity losses in the fiber lines are automatically compensated. Meantime, an optical fiber sensor model of correcting static error based on BP artificial neural network (ANN) is set up. Also by using interpolation method and value filtering to process the signals, effectively reduce the influence of random noise and the vibration of the roller bearing. So enhance the accuracy and resolution remarkably. Experiment proves that the accuracy of the system reach to the demand of practical production process, it provides a new method for the high speed, accurate and automatic on line detection of the mill roller shape.

Real-time biochemical sensor based on Raman scattering with CMOS contact imaging.

PubMed

Muyun Cao; Yuhua Li; Yadid-Pecht, Orly

2015-08-01

This work presents a biochemical sensor based on Raman scattering with Complementary metal-oxide-semiconductor (CMOS) contact imaging. This biochemical optical sensor is designed for detecting the concentration of solutions. The system is built with a laser diode, an optical filter, a sample holder and a commercial CMOS sensor. The output of the system is analyzed by an image processing program. The system provides instant measurements with a resolution of 0.2 to 0.4 Mol. This low cost and easy-operated small scale system is useful in chemical, biomedical and environmental labs for quantitative bio-chemical concentration detection with results reported comparable to a highly cost commercial spectrometer.

Molecular breast imaging using a dedicated high-performance instrument

NASA Astrophysics Data System (ADS)

O'Connor, Michael K.; Wagenaar, Douglas; Hruska, Carrie B.; Phillips, Stephen; Caravaglia, Gina; Rhodes, Deborah

2006-08-01

In women with radiographically dense breasts, the sensitivity of mammography is less than 50%. With the increase in the percent of women with dense breasts, it is important to look at alternative screening techniques for this population. This article reviews the strengths and weaknesses of current imaging techniques and focuses on recent developments in semiconductor-based gamma camera systems that offer significant improvements in image quality over that achievable with single-crystal sodium iodide systems. We have developed a technique known as Molecular Breast Imaging (MBI) using small field of view Cadmium Zinc Telluride (CZT) gamma cameras that permits the breast to be imaged in a similar manner to mammography, using light pain-free compression. Computer simulations and experimental studies have shown that use of low-energy high sensitivity collimation coupled with the excellent energy resolution and intrinsic spatial resolution of CZT detectors provides optimum image quality for the detection of small breast lesions. Preliminary clinical studies with a prototype dual-detector system have demonstrated that Molecular Breast Imaging has a sensitivity of ~90% for the detection of breast tumors less than 10 mm in diameter. By comparison, conventional scintimammography only achieves a sensitivity of 50% in the detection of lesions < 10 mm. Because Molecular Breast Imaging is not affected by breast density, this technique may offer an important adjunct to mammography in the evaluation of women with dense breast parenchyma.

Autonomous collection of dynamically-cued multi-sensor imagery

NASA Astrophysics Data System (ADS)

Daniel, Brian; Wilson, Michael L.; Edelberg, Jason; Jensen, Mark; Johnson, Troy; Anderson, Scott

2011-05-01

The availability of imagery simultaneously collected from sensors of disparate modalities enhances an image analyst's situational awareness and expands the overall detection capability to a larger array of target classes. Dynamic cooperation between sensors is increasingly important for the collection of coincident data from multiple sensors either on the same or on different platforms suitable for UAV deployment. Of particular interest is autonomous collaboration between wide area survey detection, high-resolution inspection, and RF sensors that span large segments of the electromagnetic spectrum. The Naval Research Laboratory (NRL) in conjunction with the Space Dynamics Laboratory (SDL) is building sensors with such networked communications capability and is conducting field tests to demonstrate the feasibility of collaborative sensor data collection and exploitation. Example survey / detection sensors include: NuSAR (NRL Unmanned SAR), a UAV compatible synthetic aperture radar system; microHSI, an NRL developed lightweight hyper-spectral imager; RASAR (Real-time Autonomous SAR), a lightweight podded synthetic aperture radar; and N-WAPSS-16 (Nighttime Wide-Area Persistent Surveillance Sensor-16Mpix), a MWIR large array gimbaled system. From these sensors, detected target cues are automatically sent to the NRL/SDL developed EyePod, a high-resolution, narrow FOV EO/IR sensor, for target inspection. In addition to this cooperative data collection, EyePod's real-time, autonomous target tracking capabilities will be demonstrated. Preliminary results and target analysis will be presented.

A wireless beta-microprobe based on pixelated silicon for in vivo brain studies in freely moving rats

NASA Astrophysics Data System (ADS)

Märk, J.; Benoit, D.; Balasse, L.; Benoit, M.; Clémens, J. C.; Fieux, S.; Fougeron, D.; Graber-Bolis, J.; Janvier, B.; Jevaud, M.; Genoux, A.; Gisquet-Verrier, P.; Menouni, M.; Pain, F.; Pinot, L.; Tourvielle, C.; Zimmer, L.; Morel, C.; Laniece, P.

2013-07-01

The investigation of neurophysiological mechanisms underlying the functional specificity of brain regions requires the development of technologies that are well adjusted to in vivo studies in small animals. An exciting challenge remains the combination of brain imaging and behavioural studies, which associates molecular processes of neuronal communications to their related actions. A pixelated intracerebral probe (PIXSIC) presents a novel strategy using a submillimetric probe for beta+ radiotracer detection based on a pixelated silicon diode that can be stereotaxically implanted in the brain region of interest. This fully autonomous detection system permits time-resolved high sensitivity measurements of radiotracers with additional imaging features in freely moving rats. An application-specific integrated circuit (ASIC) allows for parallel signal processing of each pixel and enables the wireless operation. All components of the detector were tested and characterized. The beta+ sensitivity of the system was determined with the probe dipped into radiotracer solutions. Monte Carlo simulations served to validate the experimental values and assess the contribution of gamma noise. Preliminary implantation tests on anaesthetized rats proved PIXSIC's functionality in brain tissue. High spatial resolution allows for the visualization of radiotracer concentration in different brain regions with high temporal resolution.

Applications of Cavity-Enhanced Direct Frequency Comb Spectroscopy

NASA Astrophysics Data System (ADS)

Cossel, Kevin C.; Adler, Florian; Maslowski, Piotr; Ye, Jun

2010-06-01

Cavity-enhanced direct frequency comb spectroscopy (CE-DFCS) is a unique technique that provides broad bandwidth, high resolution, and ultra-high detection sensitivities. This is accomplished by combining a femtosecond laser based optical frequency comb with an enhancement cavity and a broadband, multichannel imaging system. These systems are capable of simultaneously recording many terahertz of spectral bandwidth with sub-gigahertz resolution and absorption sensitivities of 1×10-7 cm-1 Hz-1/2. In addition, the ultrashort pulses enable efficient nonlinear processes, which makes it possible to reach spectral regions that are difficult to access with conventional laser sources. We will present an application of CE-DFCS for trace impurity detection in the semiconductor processing gas arsine near 1.8 μm and the development of a high-power, mid-infrared frequency comb for breath analysis in the 2.8-4.8 μm region. M. J. Thorpe, K. D. Moll, R. J. Jones, B. Safdi, and J. Ye. Science 311, 1595-1599 (2006) F. Adler, M. J. Thorpe, K. C. Cossel, and J. Ye. Annu. Rev. Anal. Chem. 3, 175-205 (2010) F. Adler, K. C. Cossel, M. J. Thorpe, I. Hartl, M. E. Fermann, and J. Ye. Opt. Lett. 34, 1330-1332 (2009)

Preliminary study of a millimeter wave FMCW InSAR for UAS indoor navigation.

PubMed

Scannapieco, Antonio F; Renga, Alfredo; Moccia, Antonio

2015-01-22

Small autonomous unmanned aerial systems (UAS) could be used for indoor inspection in emergency missions, such as damage assessment or the search for survivors in dangerous environments, e.g., power plants, underground railways, mines and industrial warehouses. Two basic functions are required to carry out these tasks, that is autonomous GPS-denied navigation with obstacle detection and high-resolution 3Dmapping with moving target detection. State-of-the-art sensors for UAS are very sensitive to environmental conditions and often fail in the case of poor visibility caused by dust, fog, smoke, flames or other factors that are met as nominal mission scenarios when operating indoors. This paper is a preliminary study concerning an innovative radar sensor based on the interferometric Synthetic Aperture Radar (SAR) principle, which has the potential to satisfy stringent requirements set by indoor autonomous operation. An architectural solution based on a frequency-modulated continuous wave (FMCW) scheme is proposed after a detailed analysis of existing compact and lightweight SAR. A preliminary system design is obtained, and the main imaging peculiarities of the novel sensor are discussed, demonstrating that high-resolution, high-quality observation of an assigned control volume can be achieved.

Preliminary Study of a Millimeter Wave FMCW InSAR for UAS Indoor Navigation

PubMed Central

Scannapieco, Antonio F.; Renga, Alfredo; Moccia, Antonio

2015-01-01

Small autonomous unmanned aerial systems (UAS) could be used for indoor inspection in emergency missions, such as damage assessment or the search for survivors in dangerous environments, e.g., power plants, underground railways, mines and industrial warehouses. Two basic functions are required to carry out these tasks, that is autonomous GPS-denied navigation with obstacle detection and high-resolution 3D mapping with moving target detection. State-of-the-art sensors for UAS are very sensitive to environmental conditions and often fail in the case of poor visibility caused by dust, fog, smoke, flames or other factors that are met as nominal mission scenarios when operating indoors. This paper is a preliminary study concerning an innovative radar sensor based on the interferometric Synthetic Aperture Radar (SAR) principle, which has the potential to satisfy stringent requirements set by indoor autonomous operation. An architectural solution based on a frequency-modulated continuous wave (FMCW) scheme is proposed after a detailed analysis of existing compact and lightweight SAR. A preliminary system design is obtained, and the main imaging peculiarities of the novel sensor are discussed, demonstrating that high-resolution, high-quality observation of an assigned control volume can be achieved. PMID:25621606

Lensless high-resolution photoacoustic imaging scanner for in vivo skin imaging

NASA Astrophysics Data System (ADS)

Ida, Taiichiro; Iwazaki, Hideaki; Omuro, Toshiyuki; Kawaguchi, Yasushi; Tsunoi, Yasuyuki; Kawauchi, Satoko; Sato, Shunichi

2018-02-01

We previously launched a high-resolution photoacoustic (PA) imaging scanner based on a unique lensless design for in vivo skin imaging. The design, imaging algorithm and characteristics of the system are described in this paper. Neither an optical lens nor an acoustic lens is used in the system. In the imaging head, four sensor elements are arranged quadrilaterally, and by checking the phase differences for PA waves detected with these four sensors, a set of PA signals only originating from a chromophore located on the sensor center axis is extracted for constructing an image. A phantom study using a carbon fiber showed a depth-independent horizontal resolution of 84.0 ± 3.5 µm, and the scan direction-dependent variation of PA signals was about ± 20%. We then performed imaging of vasculature phantoms: patterns of red ink lines with widths of 100 or 200 μm formed in an acrylic block co-polymer. The patterns were visualized with high contrast, showing the capability for imaging arterioles and venues in the skin. Vasculatures in rat burn models and healthy human skin were also clearly visualized in vivo.

Low Frequency Error Analysis and Calibration for High-Resolution Optical Satellite's Uncontrolled Geometric Positioning

NASA Astrophysics Data System (ADS)

Wang, Mi; Fang, Chengcheng; Yang, Bo; Cheng, Yufeng

2016-06-01

The low frequency error is a key factor which has affected uncontrolled geometry processing accuracy of the high-resolution optical image. To guarantee the geometric quality of imagery, this paper presents an on-orbit calibration method for the low frequency error based on geometric calibration field. Firstly, we introduce the overall flow of low frequency error on-orbit analysis and calibration, which includes optical axis angle variation detection of star sensor, relative calibration among star sensors, multi-star sensor information fusion, low frequency error model construction and verification. Secondly, we use optical axis angle change detection method to analyze the law of low frequency error variation. Thirdly, we respectively use the method of relative calibration and information fusion among star sensors to realize the datum unity and high precision attitude output. Finally, we realize the low frequency error model construction and optimal estimation of model parameters based on DEM/DOM of geometric calibration field. To evaluate the performance of the proposed calibration method, a certain type satellite's real data is used. Test results demonstrate that the calibration model in this paper can well describe the law of the low frequency error variation. The uncontrolled geometric positioning accuracy of the high-resolution optical image in the WGS-84 Coordinate Systems is obviously improved after the step-wise calibration.

Low cost, multiscale and multi-sensor application for flooded area mapping

NASA Astrophysics Data System (ADS)

Giordan, Daniele; Notti, Davide; Villa, Alfredo; Zucca, Francesco; Calò, Fabiana; Pepe, Antonio; Dutto, Furio; Pari, Paolo; Baldo, Marco; Allasia, Paolo

2018-05-01

Flood mapping and estimation of the maximum water depth are essential elements for the first damage evaluation, civil protection intervention planning and detection of areas where remediation is needed. In this work, we present and discuss a methodology for mapping and quantifying flood severity over floodplains. The proposed methodology considers a multiscale and multi-sensor approach using free or low-cost data and sensors. We applied this method to the November 2016 Piedmont (northwestern Italy) flood. We first mapped the flooded areas at the basin scale using free satellite data from low- to medium-high-resolution from both the SAR (Sentinel-1, COSMO-Skymed) and multispectral sensors (MODIS, Sentinel-2). Using very- and ultra-high-resolution images from the low-cost aerial platform and remotely piloted aerial system, we refined the flooded zone and detected the most damaged sector. The presented method considers both urbanised and non-urbanised areas. Nadiral images have several limitations, in particular in urbanised areas, where the use of terrestrial images solved this limitation. Very- and ultra-high-resolution images were processed with structure from motion (SfM) for the realisation of 3-D models. These data, combined with an available digital terrain model, allowed us to obtain maps of the flooded area, maximum high water area and damaged infrastructures.

The ASTER Volcano Archive (AVA): High Spatial Resolution Global Monitoring of Volcanic Eruptions

NASA Astrophysics Data System (ADS)

Linick, J. P.; Pieri, D. C.; Davies, A. G.; Reath, K.; Mars, J. C.; Hubbard, B. E.; Sanchez, R. M.; Tan, H. L.

2017-12-01

The ASTER Volcano Archive (AVA) is a data system focused on collecting and cataloguing higher level remote sensing data products for all Holocene volcanoes over the last several decades, producing volcanogenic science products for global detection, mapping, and modeling of effusive eruptions at high spatial resolution, and providing rapid bulk dissemination of relevant data products to the science community at large. Space-based optical platforms such as ASTER, EO-1, and Landsat, are a critical component for global monitoring systems to provide the capability for volcanic hazard assessment and modeling, and are a vital addition to in-situ measurements. The AVA leverages these instruments for the automated generation of lava flow emplacement maps, sulfur dioxide monitoring, thermal anomaly detection, and modeling of integrated thermal emission across the world's volcanoes. Additionally, we provide slope classified alteration and lahar inundation maps with potential inundation zones for certain relevant volcanoes. We explore the AVA's data product retrieval API, and describe how scientists can rapidly retrieve bulk products using the AVA platform with a focus on practical applications for both general analysis and hazard response.

Ion-ion coincidence imaging at high event rate using an in-vacuum pixel detector.

PubMed

Long, Jingming; Furch, Federico J; Durá, Judith; Tremsin, Anton S; Vallerga, John; Schulz, Claus Peter; Rouzée, Arnaud; Vrakking, Marc J J

2017-07-07

A new ion-ion coincidence imaging spectrometer based on a pixelated complementary metal-oxide-semiconductor detector has been developed for the investigation of molecular ionization and fragmentation processes in strong laser fields. Used as a part of a velocity map imaging spectrometer, the detection system is comprised of a set of microchannel plates and a Timepix detector. A fast time-to-digital converter (TDC) is used to enhance the ion time-of-flight resolution by correlating timestamps registered separately by the Timepix detector and the TDC. In addition, sub-pixel spatial resolution (<6 μm) is achieved by the use of a center-of-mass centroiding algorithm. This performance is achieved while retaining a high event rate (10 4 per s). The spectrometer was characterized and used in a proof-of-principle experiment on strong field dissociative double ionization of carbon dioxide molecules (CO 2 ), using a 400 kHz repetition rate laser system. The experimental results demonstrate that the spectrometer can detect multiple ions in coincidence, making it a valuable tool for studying the fragmentation dynamics of molecules in strong laser fields.

Ion-ion coincidence imaging at high event rate using an in-vacuum pixel detector

NASA Astrophysics Data System (ADS)

Long, Jingming; Furch, Federico J.; Durá, Judith; Tremsin, Anton S.; Vallerga, John; Schulz, Claus Peter; Rouzée, Arnaud; Vrakking, Marc J. J.

2017-07-01

A new ion-ion coincidence imaging spectrometer based on a pixelated complementary metal-oxide-semiconductor detector has been developed for the investigation of molecular ionization and fragmentation processes in strong laser fields. Used as a part of a velocity map imaging spectrometer, the detection system is comprised of a set of microchannel plates and a Timepix detector. A fast time-to-digital converter (TDC) is used to enhance the ion time-of-flight resolution by correlating timestamps registered separately by the Timepix detector and the TDC. In addition, sub-pixel spatial resolution (<6 μm) is achieved by the use of a center-of-mass centroiding algorithm. This performance is achieved while retaining a high event rate (104 per s). The spectrometer was characterized and used in a proof-of-principle experiment on strong field dissociative double ionization of carbon dioxide molecules (CO2), using a 400 kHz repetition rate laser system. The experimental results demonstrate that the spectrometer can detect multiple ions in coincidence, making it a valuable tool for studying the fragmentation dynamics of molecules in strong laser fields.

An advanced scanning method for space-borne hyper-spectral imaging system

NASA Astrophysics Data System (ADS)

Wang, Yue-ming; Lang, Jun-Wei; Wang, Jian-Yu; Jiang, Zi-Qing

2011-08-01

Space-borne hyper-spectral imagery is an important means for the studies and applications of earth science. High cost efficiency could be acquired by optimized system design. In this paper, an advanced scanning method is proposed, which contributes to implement both high temporal and spatial resolution imaging system. Revisit frequency and effective working time of space-borne hyper-spectral imagers could be greatly improved by adopting two-axis scanning system if spatial resolution and radiometric accuracy are not harshly demanded. In order to avoid the quality degradation caused by image rotation, an idea of two-axis rotation has been presented based on the analysis and simulation of two-dimensional scanning motion path and features. Further improvement of the imagers' detection ability under the conditions of small solar altitude angle and low surface reflectance can be realized by the Ground Motion Compensation on pitch axis. The structure and control performance are also described. An intelligent integration technology of two-dimensional scanning and image motion compensation is elaborated in this paper. With this technology, sun-synchronous hyper-spectral imagers are able to pay quick visit to hot spots, acquiring both high spatial and temporal resolution hyper-spectral images, which enables rapid response of emergencies. The result has reference value for developing operational space-borne hyper-spectral imagers.

Online High Temporal Resolution Measurement of Atmospheric Sulfate and Sulfur Trioxide with a Light Emitting Diode and Liquid Core Waveguide-Based Sensor.

PubMed

Tian, Yong; Shen, Huiyan; Wang, Qiang; Liu, Aifeng; Gao, Wei; Chen, Xu-Wei; Chen, Ming-Li; Zhao, Zongshan

2018-06-13

High temporal resolution components analysis is still a great challenge for the frontier of atmospheric aerosol research. Here, an online high time resolution method for monitoring soluble sulfate and sulfur trioxide in atmospheric aerosols was developed by integrating a membrane-based parallel plate denuder, a particle collector, and a liquid waveguide capillary cell into a flow injection analysis system. The BaCl 2 solution (containing HCl, glycerin, and ethanol) was enabled to quantitatively transform sulfate into a well-distributed BaSO 4 solution for turbidimetric detection. The time resolution for monitoring the soluble sulfate and sulfur trioxide was 15 h -1 . The limits of detection were 86 and 7.3 μg L -1 ( S/ N = 3) with a 20 and 200 μL SO 4 2- solution injection, respectively. Both the interday and intraday precision values (relative standard deviation) were less than 6.0%. The analytical results of the certificated reference materials (GBW(E)08026 and GNM-M07117-2013) were identical to the certified values (no significant difference at a 95% confidence level). The validity and practicability of the developed device were also evaluated during a firecracker day and a routine day, obviously revealing the continuous variance in atmospheric sulfate and sulfur trioxide in both interday and intraday studies.

Optical coherence microscope for invariant high resolution in vivo skin imaging

NASA Astrophysics Data System (ADS)

Murali, S.; Lee, K. S.; Meemon, P.; Rolland, J. P.

2008-02-01

A non-invasive, reliable and affordable imaging system with the capability of detecting skin pathologies such as skin cancer would be a valuable tool to use for pre-screening and diagnostic applications. Optical Coherence Microscopy (OCM) is emerging as a building block for in vivo optical diagnosis, where high numerical aperture optics is introduced in the sample arm to achieve high lateral resolution. While high numerical aperture optics enables realizing high lateral resolution at the focus point, dynamic focusing is required to maintain the target lateral resolution throughout the depth of the sample being imaged. In this paper, we demonstrate the ability to dynamically focus in real-time with no moving parts to a depth of up to 2mm in skin-equivalent tissue in order to achieve 3.5μm lateral resolution throughout an 8 cubic millimeter sample. The built-in dynamic focusing ability is provided by an addressable liquid lens embedded in custom-designed optics which was designed for a broadband laser source of 120 nm bandwidth centered at around 800nm. The imaging probe was designed to be low-cost and portable. Design evaluation and tolerance analysis results show that the probe is robust to manufacturing errors and produces consistent high performance throughout the imaging volume.

Spectroscopic Characterisation of CARMENES Target Candidates from FEROS, CAFE and HRS High-Resolution Spectra

NASA Astrophysics Data System (ADS)

Passegger, Vera Maria; Reiners, Ansgar; Jeffers, Sandra V.; Wende, Sebastian; Schöfer, Patrick; Amado, Pedro J.; Caballero, Jose A.; Montes, David; Mundt, Reinhard; Ribas, Ignasi; Quirrenbach, Andreas

2016-07-01

CARMENES (Calar Alto high-Resolution search for M dwarfs with Exoearths with Near-infrared and optical Échelle Spectrographs) started a new planet survey on M-dwarfs in January this year. The new high-resolution spectrographs are operating in the visible and near-infrared at Calar Alto Observatory. They will perform high-accuracy radial-velocity measurements (goal 1 m s-1) of about 300 M-dwarfs with the aim to detect low-mass planets within habitable zones. We characterised the candidate sample for CARMENES and provide fundamental parameters for these stars in order to constrain planetary properties and understand star-planet systems. Using state-of-the-art model atmospheres (PHOENIX-ACES) and χ2-minimization with a downhill-simplex method we determine effective temperature, surface gravity and metallicity [Fe/H] for high-resolution spectra of around 480 stars of spectral types M0.0-6.5V taken with FEROS, CAFE and HRS. We find good agreement between the models and our observed high-resolution spectra. We show the performance of the algorithm, as well as results, parameter and spectral type distributions for the CARMENES candidate sample, which is used to define the CARMENES target sample. We also present first preliminary results obtained from CARMENES spectra.

Quantification of polychlorinated dibenzo-p-dioxins and dibenzofurans by direct injection of sample extract into the comprehensive multidimensional gas chromatograph/high-resolution time-of-flight mass spectrometer.

PubMed

Shunji, Hashimoto; Yoshikatsu, Takazawa; Akihiro, Fushimi; Hiroyasu, Ito; Kiyoshi, Tanabe; Yasuyuki, Shibata; Masa-aki, Ubukata; Akihiko, Kusai; Kazuo, Tanaka; Hideyuki, Otsuka; Katsunori, Anezaki

2008-01-18

Polychlorinated dibenzo-p-dioxins and dibenzofurans in crude extracts of fly ash and flue gas from municipal waste incinerators were quantified using a comprehensive multidimensional gas chromatograph (GC x GC) coupled to a high-resolution time-of-flight mass spectrometer (HR-TOFMS). For identification and quantification, we developed our own program to prepare 3D chromatograms of selected mass numbers from the data of the GC x GC/HR-TOFMS. Isolation of all congeners with a TCDD toxic equivalency factor from the other isomers by only one injection was confirmed. The instrumental detection limit of TCDD on the GC x GC/HR-TOFMS was 0.9 pg by the relative calibration method. Quantification of these substances in the crude extracts was achieved by direct injection to the GC x GC/HR-TOFMS. The results agree with the values obtained using a generic gas chromatography/high-resolution mass spectrometry (GC/HRMS) system. It was confirmed that measurement by high-resolution TOFMS and GC x GC effectively reduces interference from other chemicals.

Combined micro-Raman/UV-visible/fluorescence spectrometer for high-throughput analysis of microsamples.

PubMed

Noh, Jermim; Suh, Yung Doug; Park, Yong Ki; Jin, Seung Min; Kim, Soo Ho; Woo, Seong Ihl

2007-07-01

Combined micro-Raman/UV-visible (vis)/fluorescence spectroscopy system, which can evaluate an integrated array of more than 10,000 microsamples with a minimuma size of 5 microm within a few hours, has been developed for the first time. The array of microsamples is positioned on a computer-controlled XY translation microstage with a spatial resolution of 1 mum so that the spectra can be mapped with micron precision. Micro-Raman spectrometers have a high spectral resolution of about 2 cm(-1) over the wave number range of 150-3900 cm(-1), while UV-vis and fluorescence spectrometers have high spectral resolutions of 0.4 and 0.1 nm over the wavelength range of 190-900 nm, respectively. In particular, the signal-to-noise ratio of the micro-Raman spectroscopy has been improved by using a holographic Raman grating and a liquid-nitrogen-cooled charge-coupled device detector. The performance of the combined spectroscopy system has been demonstrated by the high-throughput screening of a combinatorial ferroelectric (i.e., BaTi(x)Zr(1-x)O(3)) library. This system makes possible the structure analysis of various materials including ferroelectrics, catalysts, phosphors, polymers, alloys, and so on for the development of novel materials and the ultrasensitive detection of trace amounts of pharmaceuticals and diagnostic agents.

Microwave-photonics direction finding system for interception of low probability of intercept radio frequency signals

NASA Astrophysics Data System (ADS)

Pace, Phillip Eric; Tan, Chew Kung; Ong, Chee K.

2018-02-01

Direction finding (DF) systems are fundamental electronic support measures for electronic warfare. A number of DF techniques have been developed over the years; however, these systems are limited in bandwidth and resolution and suffer from a complex design for frequency downconversion. The design of a photonic DF technique for the detection and DF of low probability of intercept (LPI) signals is investigated. Key advantages of this design include a small baseline, wide bandwidth, high resolution, minimal space, weight, and power requirement. A robust postprocessing algorithm that utilizes the minimum Euclidean distance detector provides consistence and accurate estimation of angle of arrival (AoA) for a wide range of LPI waveforms. Experimental tests using frequency modulation continuous wave (FMCW) and P4 modulation signals were conducted in an anechoic chamber to verify the system design. Test results showed that the photonic DF system is capable of measuring the AoA of the LPI signals with 1-deg resolution over a 180 deg field-of-view. For an FMCW signal, the AoA was determined with a RMS error of 0.29 deg at 1-deg resolution. For a P4 coded signal, the RMS error in estimating the AoA is 0.32 deg at 1-deg resolution.

Singular value decomposition metrics show limitations of detector design in diffuse fluorescence tomography

PubMed Central

Leblond, Frederic; Tichauer, Kenneth M.; Pogue, Brian W.

2010-01-01

The spatial resolution and recovered contrast of images reconstructed from diffuse fluorescence tomography data are limited by the high scattering properties of light propagation in biological tissue. As a result, the image reconstruction process can be exceedingly vulnerable to inaccurate prior knowledge of tissue optical properties and stochastic noise. In light of these limitations, the optimal source-detector geometry for a fluorescence tomography system is non-trivial, requiring analytical methods to guide design. Analysis of the singular value decomposition of the matrix to be inverted for image reconstruction is one potential approach, providing key quantitative metrics, such as singular image mode spatial resolution and singular data mode frequency as a function of singular mode. In the present study, these metrics are used to analyze the effects of different sources of noise and model errors as related to image quality in the form of spatial resolution and contrast recovery. The image quality is demonstrated to be inherently noise-limited even when detection geometries were increased in complexity to allow maximal tissue sampling, suggesting that detection noise characteristics outweigh detection geometry for achieving optimal reconstructions. PMID:21258566

Mobile seismic exploration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dräbenstedt, A., E-mail: a.draebenstedt@polytec.de, E-mail: rembe@iei.tu-clausthal.de, E-mail: ulrich.polom@liag-hannover.de; Seyfried, V.; Cao, X.

2016-06-28

Laser-Doppler-Vibrometry (LDV) is an established technique to measure vibrations in technical systems with picometer vibration-amplitude resolution. Especially good sensitivity and resolution can be achieved at an infrared wavelength of 1550 nm. High-resolution vibration measurements are possible over more than 100 m distance. This advancement of the LDV technique enables new applications. The detection of seismic waves is an application which has not been investigated so far because seismic waves outside laboratory scales are usually analyzed at low frequencies between approximately 1 Hz and 250 Hz and require velocity resolutions in the range below 1 nm/s/√Hz. Thermal displacements and air turbulence have critical influences to LDVmore » measurements at this low-frequency range leading to noise levels of several 100 nm/√Hz. Commonly seismic waves are measured with highly sensitive inertial sensors (geophones or Micro Electro-Mechanical Sensors (MEMS)). Approaching a laser geophone based on LDV technique is the topic of this paper. We have assembled an actively vibration-isolated optical table in a minivan which provides a hole in its underbody. The laser-beam of an infrared LDV assembled on the optical table impinges the ground below the car through the hole. A reference geophone has detected remaining vibrations on the table. We present the results from the first successful experimental demonstration of contactless detection of seismic waves from a movable vehicle with a LDV as laser geophone.« less

Preventive doping control screening analysis of prohibited substances in human urine using rapid-resolution liquid chromatography/high-resolution time-of-flight mass spectrometry.

PubMed

Vonaparti, A; Lyris, E; Angelis, Y S; Panderi, I; Koupparis, M; Tsantili-Kakoulidou, A; Peters, R J B; Nielen, M W F; Georgakopoulos, C

2010-06-15

Unification of the screening protocols for a wide range of doping agents has become an important issue for doping control laboratories. This study presents the development and validation of a generic liquid chromatography/time-of-flight mass spectrometry (LC/TOFMS) screening method of 241 small molecule analytes from various categories of prohibited substances (stimulants, narcotics, diuretics, beta(2)-agonists, beta-blockers, hormone antagonists and modulators, glucocorticosteroids and anabolic agents). It is based on a single-step liquid-liquid extraction of hydrolyzed urine and the use of a rapid-resolution liquid chromatography/high-resolution time-of-flight mass spectrometric system acquiring continuous full scan data. Electrospray ionization in the positive mode was used. Validation parameters consisted of identification capability, limit of detection, specificity, ion suppression, extraction recovery, repeatability and mass accuracy. Detection criteria were established on the basis of retention time reproducibility and mass accuracy. The suitability of the methodology for doping control was demonstrated with positive urine samples. The preventive role of the method was proved by the case where full scan acquisition with accurate mass measurement allowed the retrospective reprocessing of acquired data from past doping control samples for the detection of a designer drug, the stimulant 4-methyl-2-hexanamine, which resulted in re-reporting a number of stored samples as positives for this particular substance, when, initially, they had been reported as negatives. Copyright (c) 2010 John Wiley & Sons, Ltd.

St 2-22 - Another Symbiotic Star with High-Velocity Bipolar Jets

NASA Astrophysics Data System (ADS)

Tomov, T.; Zamanov, R.; Gałan, C.; Pietrukowicz, P.

2017-09-01

We report the detection of high-velocity components in the wings of Hα emission line in spectra of symbiotic binary star St 2-22 obtained in 2005. This finding encouraged us to start the present investigation in order to show that this poorly-studied object is a jet-producing system. We have used high-resolution optical and low-resolution near-infrared spectra, as well as available optical and infrared photometry, to evaluate some physical parameters of the St 2-22 components and characteristics of the jets. We confirm that St 2-22 is a S-type symbiotic star. Our results demonstrate that an unnoticed outburst, similar to those in classical symbiotic systems, occurred in the first half of 2005. During the outburst, collimated bipolar jets were ejected by the hot component of St 2-22 with an average velocity of about 1700 km/s.

The CHARIS IFS for high contrast imaging at Subaru

NASA Technical Reports Server (NTRS)

Groff, Tyler D.; Kasdin, N. Jeremy; Limbach, Mary Anne; Galvin, Michael; Carr, Michael A.; Knapp, Gillian; Brandt, Timothy; Loomis, Craig; Jarosik, Norman; Mede, Kyle;

Multibeam monopulse radar for airborne sense and avoid system

NASA Astrophysics Data System (ADS)

Gorwara, Ashok; Molchanov, Pavlo

2016-10-01

The multibeam monopulse radar for Airborne Based Sense and Avoid (ABSAA) system concept is the next step in the development of passive monopulse direction finder proposed by Stephen E. Lipsky in the 80s. In the proposed system the multibeam monopulse radar with an array of directional antennas is positioned on a small aircaraft or Unmanned Aircraft System (UAS). Radar signals are simultaneously transmitted and received by multiple angle shifted directional antennas with overlapping antenna patterns and the entire sky, 360° for both horizontal and vertical coverage. Digitizing of amplitude and phase of signals in separate directional antennas relative to reference signals provides high-accuracy high-resolution range and azimuth measurement and allows to record real time amplitude and phase of reflected from non-cooperative aircraft signals. High resolution range and azimuth measurement provides minimal tracking errors in both position and velocity of non-cooperative aircraft and determined by sampling frequency of the digitizer. High speed sampling with high-accuracy processor clock provides high resolution phase/time domain measurement even for directional antennas with wide Field of View (FOV). Fourier transform (frequency domain processing) of received radar signals provides signatures and dramatically increases probability of detection for non-cooperative aircraft. Steering of transmitting power and integration, correlation period of received reflected signals for separate antennas (directions) allows dramatically decreased ground clutter for low altitude flights. An open architecture, modular construction allows the combination of a radar sensor with Automatic Dependent Surveillance - Broadcast (ADS-B), electro-optic, acoustic sensors.

Automation and Preclinical Evaluation of a Dedicated Emission Mammotomography System for Fully 3-D Molecular Breast Imaging

DTIC Science & Technology

2009-10-01

molecular breast imaging, with the ability to dynamically contour any sized breast, will improve detection and potentially in vivo characterization of...Having flexible 3D positioning about the breast yielded minimal RMSD differences, which is important for high resolution molecular emission imaging. This...TITLE: Automation and Preclinical Evaluation of a Dedicated Emission Mammotomography System for Fully 3-D Molecular Breast Imaging PRINCIPAL

Rapid Target Detection in High Resolution Remote Sensing Images Using Yolo Model

NASA Astrophysics Data System (ADS)

Wu, Z.; Chen, X.; Gao, Y.; Li, Y.

2018-04-01

Object detection in high resolution remote sensing images is a fundamental and challenging problem in the field of remote sensing imagery analysis for civil and military application due to the complex neighboring environments, which can cause the recognition algorithms to mistake irrelevant ground objects for target objects. Deep Convolution Neural Network(DCNN) is the hotspot in object detection for its powerful ability of feature extraction and has achieved state-of-the-art results in Computer Vision. Common pipeline of object detection based on DCNN consists of region proposal, CNN feature extraction, region classification and post processing. YOLO model frames object detection as a regression problem, using a single CNN predicts bounding boxes and class probabilities in an end-to-end way and make the predict faster. In this paper, a YOLO based model is used for object detection in high resolution sensing images. The experiments on NWPU VHR-10 dataset and our airport/airplane dataset gain from GoogleEarth show that, compare with the common pipeline, the proposed model speeds up the detection process and have good accuracy.

Distance and Cable Length Measurement System

PubMed Central

Hernández, Sergio Elias; Acosta, Leopoldo; Toledo, Jonay

2009-01-01

A simple, economic and successful design for distance and cable length detection is presented. The measurement system is based on the continuous repetition of a pulse that endlessly travels along the distance to be detected. There is a pulse repeater at both ends of the distance or cable to be measured. The endless repetition of the pulse generates a frequency that varies almost inversely with the distance to be measured. The resolution and distance or cable length range could be adjusted by varying the repetition time delay introduced at both ends and the measurement time. With this design a distance can be measured with centimeter resolution using electronic system with microsecond resolution, simplifying classical time of flight designs which require electronics with picosecond resolution. This design was also applied to position measurement. PMID:22303169

Full-field OCT: applications in ophthalmology

NASA Astrophysics Data System (ADS)

Grieve, Kate; Dubois, Arnaud; Paques, Michel; Le Gargasson, Jean-Francois; Boccara, Albert C.

2005-04-01

We present images of ocular tissues obtained using ultrahigh resolution full-field OCT. The experimental setup is based on the Linnik interferometer, illuminated by a tungsten halogen lamp. En face tomographic images are obtained in real-time without scanning by computing the difference of two phase-opposed interferometric images recorded by a high-resolution CCD camera. A spatial resolution of 0.7 μm × 0.9 μm (axial × transverse) is achieved thanks to the short source coherence length and the use of high numerical aperture microscope objectives. A detection sensitivity of 90 dB is obtained by means of image averaging and pixel binning. Whole unfixed eyes and unstained tissue samples (cornea, lens, retina, choroid and sclera) of ex vivo rat, mouse, rabbit and porcine ocular tissues were examined. The unprecedented resolution of our instrument allows cellular-level resolution in the cornea and retina, and visualization of individual fibers in the lens. Transcorneal lens imaging was possible in all animals, and in albino animals, transscleral retinal imaging was achieved. We also introduce our rapid acquisition full-field optical coherence tomography system designed to accommodate in vivo ophthalmologic imaging. The variations on the original system technology include the introduction of a xenon arc lamp as source, and rapid image acquisition performed by a high-speed CMOS camera, reducing acquisition time to 5 ms per frame.

Daily High-Resolution Flood Maps of Africa: 1992-present with Near Real Time Updates

NASA Astrophysics Data System (ADS)

Picton, J.; Galantowicz, J. F.; Root, B.

2016-12-01

The ability to characterize past and current flood extents frequently, accurately, and at high resolution is needed for many applications including risk assessment, wetlands monitoring, and emergency management. However, remote sensing methods have not been capable of meeting all of these requirements simultaneously. Cloud cover too often obscures the surface for visual and infrared sensors and observations from radar sensors are too infrequent to create consistent historical databases or monitor evolving events. Lower-resolution (10-50 km) passive microwave sensors, such as SSM/I, AMSR-E, and AMSR2, are sensitive to water cover, acquire useful data during clear and cloudy conditions, have revisit periods of up to twice daily, and provide a continuous record of data from 1992 to the present. What they lack most is the resolution needed to map flood extent. We will present results from a flood mapping system capable of producing high-resolution (90-m) flood extent depictions from lower resolution microwave data. The system uses the strong sensitivity of microwave data to surface water coverage combined with land surface and atmospheric data to derive daily flooded fraction estimates on a sensor-footprint basis. The system downscales flooded fraction to make high-resolution Boolean flood extent depictions that are spatially continuous and consistent with the lower resolution data. The downscaling step is based on a relative floodability (RF) index derived from higher-resolution topographic and hydrological data. We process RF to create a flooded fraction threshold map that relates each 90-m grid point to the surrounding terrain at the microwave scale. We have derived daily, 90-m resolution flood maps for Africa covering 1992-present using SSM/I, AMSR-E, and AMSR2 data and we are now producing new daily maps in near real time. The flood maps are being used by the African Risk Capacity (ARC) Agency to underpin an intergovernmental river flood insurance program in Africa. We will present results showing daily flood extents during major events and discuss: validation of the flood maps against MODIS-derived maps; analyses of minimum detectable flood size; aggregate analyses of flood extent over time; flood map use in ARC's insurance model; and results applying the system to the Americas.

Programmable near-infrared ranging system

DOEpatents

Everett, Jr., Hobart R.

1989-01-01

A high angular resolution ranging system particularly suitable for indoor plications involving mobile robot navigation and collision avoidance uses a programmable array of light emitters that can be sequentially incremented by a microprocessor. A plurality of adjustable level threshold detectors are used in an optical receiver for detecting the threshold level of the light echoes produced when light emitted from one or more of the emitters is reflected by a target or object in the scan path of the ranging system.

Assessing carotid atherosclerosis by fiber-optic multispectral photoacoustic tomography

NASA Astrophysics Data System (ADS)

Hui, Jie; Li, Rui; Wang, Pu; Phillips, Evan; Bruning, Rebecca; Liao, Chien-Sheng; Sturek, Michael; Goergen, Craig J.; Cheng, Ji-Xin

2015-03-01

Atherosclerotic plaque at the carotid bifurcation is the underlying cause of the majority of ischemic strokes. Noninvasive imaging and quantification of the compositional changes preceding gross anatomic changes within the arterial wall is essential for diagnosis of disease. Current imaging modalities such as duplex ultrasound, computed tomography, positron emission tomography are limited by the lack of compositional contrast and the detection of flow-limiting lesions. Although high-resolution magnetic resonance imaging has been developed to characterize atherosclerotic plaque composition, its accessibility for wide clinical use is limited. Here, we demonstrate a fiber-based multispectral photoacoustic tomography system for excitation of lipids and external acoustic detection of the generated ultrasound. Using sequential ultrasound imaging of ex vivo preparations we achieved ~2 cm imaging depth and chemical selectivity for assessment of human arterial plaques. A multivariate curve resolution alternating least squares analysis method was applied to resolve the major chemical components, including intravascular lipid, intramuscular fat, and blood. These results show the promise of detecting carotid plaque in vivo through esophageal fiber-optic excitation of lipids and external acoustic detection of the generated ultrasound. This imaging system has great potential for serving as a point-ofcare device for early diagnosis of carotid artery disease in the clinic.

Using JPSS VIIRS Fire Radiative Power Data to Forecast Biomass Burning Emissions and Smoke Transport by the High Resolution Rapid Refresh Model

NASA Astrophysics Data System (ADS)

Ahmadov, R.; Grell, G. A.; James, E.; Alexander, C.; Stewart, J.; Benjamin, S.; McKeen, S. A.; Csiszar, I. A.; Tsidulko, M.; Pierce, R. B.; Pereira, G.; Freitas, S. R.; Goldberg, M.

2017-12-01

We present a new real-time smoke modeling system, the High Resolution Rapid Refresh coupled with smoke (HRRR-Smoke), to simulate biomass burning (BB) emissions, plume rise and smoke transport in real time. The HRRR is the NOAA Earth System Research Laboratory's 3km grid spacing version of the Weather Research and Forecasting (WRF) model used for weather forecasting. Here we make use of WRF-Chem (the WRF model coupled with chemistry) and simulate fine particulate matter (smoke) emissions emitted by BB. The HRRR-Smoke modeling system ingests fire radiative power (FRP) data from the Visible Infrared Imaging Radiometer Suite (VIIRS) sensor on the Suomi National Polar-orbiting Partnership (S-NPP) satellite to calculate BB emissions. The FRP product is based on processing 750m resolution "M" bands. The algorithms for fire detection and FRP retrieval are consistent with those used to generate the MODIS fire detection data. For the purpose of ingesting VIIRS fire data into the HRRR-Smoke model, text files are generated to provide the location and detection confidence of fire pixels, as well as FRP. The VIIRS FRP data from the text files are processed and remapped over the HRRR-Smoke model domains. We process the FRP data to calculate BB emissions (smoldering part) and fire size for the model input. In addition, HRRR-Smoke uses the FRP data to simulate the injection height for the flaming emissions using concurrently simulated meteorological fields by the model. Currently, there are two 3km resolution domains covering the contiguous US and Alaska which are used to simulate smoke in real time. In our presentation, we focus on the CONUS domain. HRRR-Smoke is initialized 4 times per day to forecast smoke concentrations for the next 36 hours. The VIIRS FRP data, as well as near-surface and vertically integrated smoke mass concentrations are visualized for every forecast hour. These plots are provided to the public via the HRRR-Smoke web-page: https://rapidrefresh.noaa.gov/HRRRsmoke/. Model evaluations for a case study are presented, where simulated smoke concentrations are compared with hourly PM2.5 measurements from EPA's Air Quality System network. These comparisons demonstrate the model's ability in simulating high aerosol loadings during major wildfire events in the western US.

Beyond the resolution limit: subpixel resolution in animals and now in silicon

NASA Astrophysics Data System (ADS)

Wilcox, M. J.

2007-09-01

Automatic acquisition of aerial threats at thousands of kilometers distance requires high sensitivity to small differences in contrast and high optical quality for subpixel resolution, since targets occupy much less surface area than a single pixel. Targets travel at high speed and break up in the re-entry phase. Target/decoy discrimination at the earliest possible time is imperative. Real time performance requires a multifaceted approach with hyperspectral imaging and analog processing allowing feature extraction in real time. Hyperacuity Systems has developed a prototype chip capable of nonlinear increase in resolution or subpixel resolution far beyond either pixel size or spacing. Performance increase is due to a biomimetic implementation of animal retinas. Photosensitivity is not homogeneous across the sensor surface, allowing pixel parsing. It is remarkably simple to provide this profile to detectors and we showed at least three ways to do so. Individual photoreceptors have a Gaussian sensitivity profile and this nonlinear profile can be exploited to extract high-resolution. Adaptive, analog circuitry provides contrast enhancement, dynamic range setting with offset and gain control. Pixels are processed in parallel within modular elements called cartridges like photo-receptor inputs in fly eyes. These modular elements are connected by a novel function for a cell matrix known as L4. The system is exquisitely sensitive to small target motion and operates with a robust signal under degraded viewing conditions, allowing detection of targets smaller than a single pixel or at greater distance. Therefore, not only is instantaneous feature extraction possible but also subpixel resolution. Analog circuitry increases processing speed with more accurate motion specification for target tracking and identification.

Correlative super-resolution fluorescence microscopy combined with optical coherence microscopy

NASA Astrophysics Data System (ADS)

Kim, Sungho; Kim, Gyeong Tae; Jang, Soohyun; Shim, Sang-Hee; Bae, Sung Chul

2015-03-01

Recent development of super-resolution fluorescence imaging technique such as stochastic optical reconstruction microscopy (STORM) and photoactived localization microscope (PALM) has brought us beyond the diffraction limits. It allows numerous opportunities in biology because vast amount of formerly obscured molecular structures, due to lack of spatial resolution, now can be directly observed. A drawback of fluorescence imaging, however, is that it lacks complete structural information. For this reason, we have developed a super-resolution multimodal imaging system based on STORM and full-field optical coherence microscopy (FF-OCM). FF-OCM is a type of interferometry systems based on a broadband light source and a bulk Michelson interferometer, which provides label-free and non-invasive visualization of biological samples. The integration between the two systems is simple because both systems use a wide-field illumination scheme and a conventional microscope. This combined imaging system gives us both functional information at a molecular level (~20nm) and structural information at the sub-cellular level (~1μm). For thick samples such as tissue slices, while FF-OCM is readily capable of imaging the 3D architecture, STORM suffer from aberrations and high background fluorescence that substantially degrade the resolution. In order to correct the aberrations in thick tissues, we employed an adaptive optics system in the detection path of the STORM microscope. We used our multimodal system to obtain images on brain tissue samples with structural and functional information.

Contrast, size, and orientation-invariant target detection in infrared imagery

NASA Astrophysics Data System (ADS)

Zhou, Yi-Tong; Crawshaw, Richard D.

1991-08-01

Automatic target detection in IR imagery is a very difficult task due to variations in target brightness, shape, size, and orientation. In this paper, the authors present a contrast, size, and orientation invariant algorithm based on Gabor functions for detecting targets from a single IR image frame. The algorithms consists of three steps. First, it locates potential targets by using low-resolution Gabor functions which resist noise and background clutter effects, then, it removes false targets and eliminates redundant target points based on a similarity measure. These two steps mimic human vision processing but are different from Zeevi's Foveating Vision System. Finally, it uses both low- and high-resolution Gabor functions to verify target existence. This algorithm has been successfully tested on several IR images that contain multiple examples of military vehicles with different size and brightness in various background scenes and orientations.

High-resolution imaging of living mammalian cells bound by nanobeads-connected antibodies in a medium using scanning electron-assisted dielectric microscopy

NASA Astrophysics Data System (ADS)

Okada, Tomoko; Ogura, Toshihiko

2017-02-01

Nanometre-scale-resolution imaging technologies for liquid-phase specimens are indispensable tools in various scientific fields. In biology, observing untreated living cells in a medium is essential for analysing cellular functions. However, nanoparticles that bind living cells in a medium are hard to detect directly using traditional optical or electron microscopy. Therefore, we previously developed a novel scanning electron-assisted dielectric microscope (SE-ADM) capable of nanoscale observations. This method enables observation of intact cells in aqueous conditions. Here, we use this SE-ADM system to clearly observe antibody-binding nanobeads in liquid-phase. We also report the successful direct detection of streptavidin-conjugated nanobeads binding to untreated cells in a medium via a biotin-conjugated anti-CD44 antibody. Our system is capable of obtaining clear images of cellular organelles and beads on the cells at the same time. The direct observation of living cells with nanoparticles in a medium allowed by our system may contribute the development of carriers for drug delivery systems (DDS).

Building Change Detection from Harvey using Unmanned Aerial System (UAS)

NASA Astrophysics Data System (ADS)

Chang, A.; Yeom, J.; Jung, J.; Choi, I.

2017-12-01

Unmanned Aerial System (UAS) is getting to be the most important technique in recent days since the fine spatial and high temporal resolution data previously unobtainable from traditional remote sensing platforms. Advanced UAS data can provide a great opportunity for disaster monitoring. Especially, building change detection is the one of the most important topics for damage assessment and recovery from disasters. This study is proposing a method to monitor building change with UAS data for Holiday Beach in Texas, where was directly hit by Harvey on 25 August 2017. This study adopted 3D change detection to monitor building damage and recovery levels with building height as well as natural color information. We used a rotorcraft UAS to collect RGB data twice on 9 September and 18 October 2017 after the hurricane. The UAS data was processed using Agisoft Photoscan Pro Software to generate super high resolution dataset including orthomosaic, DSM (Digital Surface Model), and 3D point cloud. We compared the processed dataset with an airborne image considerable as before-hurricane data, which was acquired on January 2016. Building damage and recovery levels were determined by height and color change. The result will show that UAS data is useful to assess building damage and recovery for affected area by the natural disaster such as Harvey.

Airplane detection based on fusion framework by combining saliency model with Deep Convolutional Neural Networks

NASA Astrophysics Data System (ADS)

Dou, Hao; Sun, Xiao; Li, Bin; Deng, Qianqian; Yang, Xubo; Liu, Di; Tian, Jinwen

2018-03-01

Aircraft detection from very high resolution remote sensing images, has gained more increasing interest in recent years due to the successful civil and military applications. However, several problems still exist: 1) how to extract the high-level features of aircraft; 2) locating objects within such a large image is difficult and time consuming; 3) A common problem of multiple resolutions of satellite images still exists. In this paper, inspirited by biological visual mechanism, the fusion detection framework is proposed, which fusing the top-down visual mechanism (deep CNN model) and bottom-up visual mechanism (GBVS) to detect aircraft. Besides, we use multi-scale training method for deep CNN model to solve the problem of multiple resolutions. Experimental results demonstrate that our method can achieve a better detection result than the other methods.

Solid immersion terahertz imaging with sub-wavelength resolution

NASA Astrophysics Data System (ADS)

Chernomyrdin, Nikita V.; Schadko, Aleksander O.; Lebedev, Sergey P.; Tolstoguzov, Viktor L.; Kurlov, Vladimir N.; Reshetov, Igor V.; Spektor, Igor E.; Skorobogatiy, Maksim; Yurchenko, Stanislav O.; Zaytsev, Kirill I.

2017-05-01

We have developed a method of solid immersion THz imaging—a non-contact technique employing the THz beam focused into evanescent-field volume and allowing strong reduction in the dimensions of THz caustic. We have combined numerical simulations and experimental studies to demonstrate a sub-wavelength 0.35λ0-resolution of the solid immersion THz imaging system compared to 0.85λ0-resolution of a standard imaging system, employing only an aspherical singlet. We have discussed the prospective of using the developed technique in various branches of THz science and technology, namely, for THz measurements of solid-state materials featuring sub-wavelength variations of physical properties, for highly accurate mapping of healthy and pathological tissues in THz medical diagnosis, for detection of sub-wavelength defects in THz non-destructive sensing, and for enhancement of THz nonlinear effects.

Novel method of detecting movement of the interference fringes using one-dimensional PSD.

PubMed

Wang, Qi; Xia, Ji; Liu, Xu; Zhao, Yong

2015-06-02

In this paper, a method of using a one-dimensional position-sensitive detector (PSD) by replacing charge-coupled device (CCD) to measure the movement of the interference fringes is presented first, and its feasibility is demonstrated through an experimental setup based on the principle of centroid detection. Firstly, the centroid position of the interference fringes in a fiber Mach-Zehnder (M-Z) interferometer is solved in theory, showing it has a higher resolution and sensitivity. According to the physical characteristics and principles of PSD, a simulation of the interference fringe's phase difference in fiber M-Z interferometers and PSD output is carried out. Comparing the simulation results with the relationship between phase differences and centroid positions in fiber M-Z interferometers, the conclusion that the output of interference fringes by PSD is still the centroid position is obtained. Based on massive measurements, the best resolution of the system is achieved with 5.15, 625 μm. Finally, the detection system is evaluated through setup error analysis and an ultra-narrow-band filter structure. The filter structure is configured with a one-dimensional photonic crystal containing positive and negative refraction material, which can eliminate background light in the PSD detection experiment. This detection system has a simple structure, good stability, high precision and easily performs remote measurements, which makes it potentially useful in material small deformation tests, refractivity measurements of optical media and optical wave front detection.

High-resolution computed tomography of single breast cancer microcalcifications in vivo.

PubMed

Inoue, Kazumasa; Liu, Fangbing; Hoppin, Jack; Lunsford, Elaine P; Lackas, Christian; Hesterman, Jacob; Lenkinski, Robert E; Fujii, Hirofumi; Frangioni, John V

2011-08-01

Microcalcification is a hallmark of breast cancer and a key diagnostic feature for mammography. We recently described the first robust animal model of breast cancer microcalcification. In this study, we hypothesized that high-resolution computed tomography (CT) could potentially detect the genesis of a single microcalcification in vivo and quantify its growth over time. Using a commercial CT scanner, we systematically optimized acquisition and reconstruction parameters. Two ray-tracing image reconstruction algorithms were tested: a voxel-driven "fast" cone beam algorithm (FCBA) and a detector-driven "exact" cone beam algorithm (ECBA). By optimizing acquisition and reconstruction parameters, we were able to achieve a resolution of 104 μm full width at half-maximum (FWHM). At an optimal detector sampling frequency, the ECBA provided a 28 μm (21%) FWHM improvement in resolution over the FCBA. In vitro, we were able to image a single 300 μm × 100 μm hydroxyapatite crystal. In a syngeneic rat model of breast cancer, we were able to detect the genesis of a single microcalcification in vivo and follow its growth longitudinally over weeks. Taken together, this study provides an in vivo "gold standard" for the development of calcification-specific contrast agents and a model system for studying the mechanism of breast cancer microcalcification.

[A review of mixed gas detection system based on infrared spectroscopic technique].

PubMed

Dang, Jing-Min; Fu, Li; Yan, Zi-Hui; Zheng, Chuan-Tao; Chang, Yu-Chun; Chen, Chen; Wang, Yi-Din

2014-10-01

In order to provide the experiences and references to the researchers who are working on infrared (IR) mixed gas detection field. The proposed manuscript reviews two sections of the aforementioned field, including optical multiplexing structure and detection method. At present, the coherent light sources whose representative are quantum cascade laser (QCL) and inter-band cascade laser(ICL) become the mainstream light source in IR mixed gas detection, which replace the traditional non-coherent light source, such as IR radiation source and IR light emitting diode. In addition, the photon detector which has a super high detectivity and very short response time is gradually beyond thermal infrared detector, dominant in the field of infrared detector. The optical multiplexing structure is the key factor of IR mixed gas detection system, which consists of single light source multi-plexing detection structure and multi light source multiplexing detection structure. Particularly, single light source multiplexing detection structure is advantages of small volume and high integration, which make it a plausible candidate for the portable mixed gas detection system; Meanwhile, multi light source multiplexing detection structure is embodiment of time division multiplex, frequency division multiplexing and wavelength division multiplexing, and become the leading structure of the mixed gas detection system because of its wider spectral range, higher spectral resolution, etc. The detection method applied to IR mixed gas detection includes non-dispersive infrared (NDIR) spectroscopy, wavelength and frequency-modulation spectroscopy, cavity-enhanced spectroscopy and photoacoustic spectroscopy, etc. The IR mixed gas detection system designed by researchers after recognizing the whole sections of the proposed system, which play a significant role in industrial and agricultural production, environmental monitoring, and life science, etc.

Alerts of forest disturbance from MODIS imagery

NASA Astrophysics Data System (ADS)

Hammer, Dan; Kraft, Robin; Wheeler, David

2014-12-01

This paper reports the methodology and computational strategy for a forest cover disturbance alerting system. Analytical techniques from time series econometrics are applied to imagery from the Moderate Resolution Imaging Spectroradiometer (MODIS) sensor to detect temporal instability in vegetation indices. The characteristics from each MODIS pixel's spectral history are extracted and compared against historical data on forest cover loss to develop a geographically localized classification rule that can be applied across the humid tropical biome. The final output is a probability of forest disturbance for each 500 m pixel that is updated every 16 days. The primary objective is to provide high-confidence alerts of forest disturbance, while minimizing false positives. We find that the alerts serve this purpose exceedingly well in Pará, Brazil, with high probability alerts garnering a user accuracy of 98 percent over the training period and 93 percent after the training period (2000-2005) when compared against the PRODES deforestation data set, which is used to assess spatial accuracy. Implemented in Clojure and Java on the Hadoop distributed data processing platform, the algorithm is a fast, automated, and open source system for detecting forest disturbance. It is intended to be used in conjunction with higher-resolution imagery and data products that cannot be updated as quickly as MODIS-based data products. By highlighting hotspots of change, the algorithm and associated output can focus high-resolution data acquisition and aid in efforts to enforce local forest conservation efforts.

Water-Immersible MEMS scanning mirror designed for wide-field fast-scanning photoacoustic microscopy

NASA Astrophysics Data System (ADS)

Yao, Junjie; Huang, Chih-Hsien; Martel, Catherine; Maslov, Konstantin I.; Wang, Lidai; Yang, Joon-Mo; Gao, Liang; Randolph, Gwendalyn; Zou, Jun; Wang, Lihong V.

2013-03-01

By offering images with high spatial resolution and unique optical absorption contrast, optical-resolution photoacoustic microscopy (OR-PAM) has gained increasing attention in biomedical research. Recent developments in OR-PAM have improved its imaging speed, but have sacrificed either the detection sensitivity or field of view or both. We have developed a wide-field fast-scanning OR-PAM by using a water-immersible MEMS scanning mirror (MEMS-ORPAM). Made of silicon with a gold coating, the MEMS mirror plate can reflect both optical and acoustic beams. Because it uses an electromagnetic driving force, the whole MEMS scanning system can be submerged in water. In MEMS-ORPAM, the optical and acoustic beams are confocally configured and simultaneously steered, which ensures uniform detection sensitivity. A B-scan imaging speed as high as 400 Hz can be achieved over a 3 mm scanning range. A diffraction-limited lateral resolution of 2.4 μm in water and a maximum imaging depth of 1.1 mm in soft tissue have been experimentally determined. Using the system, we imaged the flow dynamics of both red blood cells and carbon particles in a mouse ear in vivo. By using Evans blue dye as the contrast agent, we also imaged the flow dynamics of lymphatic vessels in a mouse tail in vivo. The results show that MEMS-OR-PAM could be a powerful tool for studying highly dynamic and time-sensitive biological phenomena.

All-optical optoacoustic microscopy system based on probe beam deflection technique

NASA Astrophysics Data System (ADS)

Maswadi, Saher M.; Tsyboulskic, Dmitri; Roth, Caleb C.; Glickman, Randolph D.; Beier, Hope T.; Oraevsky, Alexander A.; Ibey, Bennett L.

2016-03-01

It is difficult to achieve sub-micron resolution in backward mode OA microscopy using conventional piezoelectric detectors, because of wavefront distortions caused by components placed in the optical path, between the sample and the objective lens, that are required to separate the acoustic wave from the optical beam. As an alternate approach, an optoacoustic microscope (OAM) was constructed using the probe beam deflection technique (PBDT) to detect laserinduced acoustic signals. The all-optical OAM detects laser-generated pressure waves using a probe beam passing through a coupling medium, such as water, filling the space between the microscope objective lens and sample. The acoustic waves generated in the sample propagate through the coupling medium, causing transient changes in the refractive index that deflect the probe beam. These deflections are measured with a high-speed, balanced photodiode position detector. The deflection amplitude is directly proportional to the magnitude of the acoustic pressure wave, and provides the data required for image reconstruction. The sensitivity of the PBDT detector expressed as noise equivalent pressure was 12 Pa, comparable to that of existing high-performance ultrasound detectors. Because of the unimpeded working distance, a high numerical aperture objective lens, i.e. NA = 1, was employed in the OAM to achieve near diffraction-limited lateral resolution of 0.5 μm at 532nm. The all-optical OAM provides several benefits over current piezoelectric detector-based systems, such as increased lateral and axial resolution, higher sensitivity, robustness, and potentially more compatibility with multimodal instruments.

Prototype high resolution multienergy soft x-ray array for NSTX.

PubMed

Tritz, K; Stutman, D; Delgado-Aparicio, L; Finkenthal, M; Kaita, R; Roquemore, L

2010-10-01

A novel diagnostic design seeks to enhance the capability of multienergy soft x-ray (SXR) detection by using an image intensifier to amplify the signals from a larger set of filtered x-ray profiles. The increased number of profiles and simplified detection system provides a compact diagnostic device for measuring T(e) in addition to contributions from density and impurities. A single-energy prototype system has been implemented on NSTX, comprised of a filtered x-ray pinhole camera, which converts the x-rays to visible light using a CsI:Tl phosphor. SXR profiles have been measured in high performance plasmas at frame rates of up to 10 kHz, and comparisons to the toroidally displaced tangential multi-energy SXR have been made.

Confocal reflectance quantitative phase microscope system for cellular membranes dynamics study (Conference Presentation)

NASA Astrophysics Data System (ADS)

Singh, Vijay Raj; Yaqoob, Zahid; So, Peter T. C.

2017-02-01

Quantitative phase microscopy (QPM) techniques developed so far primarily belongs to high speed transmitted light based systems that has enough sensitivity to resolve membrane fluctuations and dynamics, but has no depth resolution. Therefore, most biomechanics studies using QPM today is confined to simple cells, such as RBCs, without internal organelles. An important instrument that will greatly extend the biomedical applications of QPM is to develop next generation microscope with 3D capability and sufficient temporal resolution to study biomechanics of complex eukaryotic cells including the mechanics of their internal compartments. For eukaryotic cells, the depth sectioning capability is critical and should be sufficient to distinguish nucleic membrane fluctuations from plasma membrane fluctuations. Further, this microscope must provide high temporal resolution since typical eukaryotes membranes are substantially stiffer than RBCs. A confocal reflectance quantitative phase microscope is presented based on multi-pinhole scanning, with the capabilities of higher temporal resolution and sensitivity for nucleic and plasma membranes of eukaryotic cells. System hardware is developed based on an array of confocal pinhole generated by using the `ON' state of subset of micro-mirrors of digital micro-mirror device (DMD, from Texas Instruments) and high-speed raster scanning provides 14ms imaging speed in wide-field mode. A common path interferometer is integrated at the imaging arm for detection of specimens' quantitative phase information. Theoretical investigation of quantitative phase reconstructed from system is investigated and application of system is presented for dimensional fluctuations measurements of both cellular plasma and nucleic membranes of embryonic stem cells.

Using a flat-panel detector in high resolution cone beam CT for dental imaging.

PubMed

Baba, R; Ueda, K; Okabe, M

2004-09-01

Cone beam CT (CBCT) requires a two-dimensional X-ray detector. In the several CBCT systems developed for dental imaging, detection has been by the combination of an X-ray image intensifier and charge-coupled device (CCD) camera. In this paper, we propose a new CBCT system in which the detector is of the flat-panel type and evaluate its performance in dental imaging. We developed a prototype CBCT that has a flat-panel-type detector. The detector consists of a CsI scintillator screen and a photosensor array. First, the flat panel detector and image intensifier detector were compared in terms of the signal-to-noise ratio (SNR) of projected images. We then used these data and a theoretical formula to evaluate noise in reconstructed images. Second, reconstructed images of a bar pattern phantom were obtained as a way of evaluating the spatial resolution. Then, reconstructed images of a skull phantom were obtained. The SNR of the developed system was 1.6 times as high as that of a system with an image intensifier detector of equal detector pitch. The system was capable of resolving a 0.35 mm pattern and its field of view almost completely encompassed that of an image intensifier detector which is used in dentomaxillofacial imaging. The fine spatial resolution of the detector led to images in which the structural details of a skull phantom were clearly visible. The system's isotropically fine resolution will lead to improved precision in dental diagnosis and surgery. The next stage of our research will be the development of a flat panel detector system with a high frame acquisition rate.

A multi-scale tensor voting approach for small retinal vessel segmentation in high resolution fundus images.

PubMed

Christodoulidis, Argyrios; Hurtut, Thomas; Tahar, Houssem Ben; Cheriet, Farida

2016-09-01

Segmenting the retinal vessels from fundus images is a prerequisite for many CAD systems for the automatic detection of diabetic retinopathy lesions. So far, research efforts have concentrated mainly on the accurate localization of the large to medium diameter vessels. However, failure to detect the smallest vessels at the segmentation step can lead to false positive lesion detection counts in a subsequent lesion analysis stage. In this study, a new hybrid method for the segmentation of the smallest vessels is proposed. Line detection and perceptual organization techniques are combined in a multi-scale scheme. Small vessels are reconstructed from the perceptual-based approach via tracking and pixel painting. The segmentation was validated in a high resolution fundus image database including healthy and diabetic subjects using pixel-based as well as perceptual-based measures. The proposed method achieves 85.06% sensitivity rate, while the original multi-scale line detection method achieves 81.06% sensitivity rate for the corresponding images (p<0.05). The improvement in the sensitivity rate for the database is 6.47% when only the smallest vessels are considered (p<0.05). For the perceptual-based measure, the proposed method improves the detection of the vasculature by 7.8% against the original multi-scale line detection method (p<0.05). Copyright © 2016 Elsevier Ltd. All rights reserved.

X-ray fluorescence imaging system for fast mapping of pigment distributions in cultural heritage paintings

NASA Astrophysics Data System (ADS)

Zielińska, A.; Dąbrowski, W.; Fiutowski, T.; Mindur, B.; Wiącek, P.; Wróbel, P.

2013-10-01

Conventional X-ray fluorescence imaging technique uses a focused X-ray beam to scan through the sample and an X-ray detector with high energy resolution but no spatial resolution. The spatial resolution of the image is then determined by the size of the exciting beam, which can be obtained either from a synchrotron source or from an X-ray tube with a micro-capillary lens. Such a technique based on a pixel-by-pixel measurement is very slow and not suitable for imaging large area samples. The goal of this work is to develop a system capable of simultaneous imaging of large area samples by using a wide field uniform excitation X-ray beam and a position sensitive and energy dispersive detector. The development is driven by possible application of such a system to imaging of distributions of hidden pigments containing specific elements in cultural heritage paintings, which is of great interest for the cultural heritage research. The fluorescence radiation from the area of 10 × 10 cm2 is projected through a pinhole camera on the Gas Electron Multiplier detector of the same area. The detector is equipped with two sets of orthogonal readout strips. The strips are read out by the GEMROC Application Specific Integrated Circuits (ASIC)s, which deliver time and amplitude information for each hit. This ASIC architecture combined with a Field Programmable Gate Array (FPGA) based readout system allows us to reconstruct the position and the total energy of each detected photon for high count rates up to 5 × 106 cps. Energy resolution better than 20% FWHM for the 5.9 keV line and spatial resolution of 1 mm FWHM have been achieved for the prototype system. Although the energy resolution of the Gas Electron Multiplier (GEM) detector is, by principle, not competitive with that of specialised high energy resolution semiconductor detectors, it is sufficient for a number of applications. Compared to conventional micro-XRF techniques the developed system allows shortening of the measurement time by 2-3 orders of magnitude.

Use of Satellite and Ground-based Digital Images to Detect and Monitor Dust Storms in the Mojave Desert

NASA Astrophysics Data System (ADS)

Chavez, P. S.; MacKinnon, D. J.; Reynolds, R. L.; Velasco, M. G.

2002-12-01

Wind-induced dust emission from sources in the southwestern United States is not a major contributor to global dust flux, but it is important on a regional and national scale because of its effects on air quality, human health and safety, as well as ecosystem dynamics. Integrated remotely sensed satellite, airborne, and ground-based image data have strong potential to detect and monitor active dust storms and map areas vulnerable to wind erosion in the Southwest. Since 1999, high temporal resolution digital images collected by satellite and a ground-based, automated digital camera station have been used to detect, monitor, and analyze the location, size, frequency, duration, and transport patterns of large dust storms in the central Mojave Desert. One of the biggest dust storms of this past decade occurred on April 15, 2002, when at least several million metric tons of dust were emitted from the central Mojave Desert alone. During this storm, geostationary satellite (GOES) images documented the arrival of two very large dust plumes into the Las Vegas Valley, NV, one from a valley about 40 km to the west and the other from a heavily used area about 170 km to the southwest. Large, rapid increases in levels of PM10 (particulate matter less than 10 micrometers) in the Las Vegas area corresponded with the arrival of these plumes, with PM10 values increasing from a range of approximately 100 to 250 micrograms/m3 to 1,100 to 1,500 micrograms/m3 within 30 minutes. Satellite imaging systems currently available cannot detect and monitor dust storms of the size typically generated in the Southwest on an operational basis or be used to produce models for emission-rate predictions. The satellite imaging system on GOES is the only one available having adequate temporal resolution to detect and monitor active dust storms on a routine basis; however, it can only detect very large dust storms because its spatial and spectral resolutions are very low. A satellite imaging system with three to five spectral bands (with adjustable gain settings) and approximately 100 m spatial and 15 to 20 minutes temporal resolutions is needed to effectively monitor southwestern dust storms and events. Such a system would also be useful in other arid regions.

Detection of monohydroxylated polycyclic aromatic hydrocarbons in urine and particulate matter using LC separations coupled with integrated SPE and fluorescence detection or coupled with high-resolution time-of-flight mass spectrometry.

PubMed

Lintelmann, Jutta; Wu, Xiao; Kuhn, Evelyn; Ritter, Sebastian; Schmidt, Claudia; Zimmermann, Ralf

2018-05-01

A high-performance liquid chromatographic (HPLC) method with integrated solid-phase extraction for the determination of 1-hydroxypyrene and 1-, 2-, 3-, 4- and 9-hydroxyphenanthrene in urine was developed and validated. After enzymatic treatment and centrifugation of 500 μL urine, 100 μL of the sample was directly injected into the HPLC system. Integrated solid-phase extraction was performed on a selective, copper phthalocyanine modified packing material. Subsequent chromatographic separation was achieved on a pentafluorophenyl core-shell column using a methanol gradient. For quantification, time-programmed fluorescence detection was used. Matrix-dependent recoveries were between 94.8 and 102.4%, repeatability and reproducibility ranged from 2.2 to 17.9% and detection limits lay between 2.6 and 13.6 ng/L urine. A set of 16 samples from normally exposed adults was analyzed using this HPLC-fluorescence detection method. Results were comparable with those reported in other studies. The chromatographic separation of the method was transferred to an ultra-high-performance liquid chromatography pentafluorophenyl core-shell column and coupled to a high-resolution time-of-flight mass spectrometer (HR-TOF-MS). The resulting method was used to demonstrate the applicability of LC-HR-TOF-MS for simultaneous target and suspect screening of monohydroxylated polycyclic aromatic hydrocarbons in extracts of urine and particulate matter. Copyright © 2018 John Wiley & Sons, Ltd.

Heterodyne frequency-domain multispectral diffuse optical tomography of breast cancer in the parallel-plane transmission geometry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ban, H. Y.; Kavuri, V. C., E-mail: venk@physics.up

Purpose: The authors introduce a state-of-the-art all-optical clinical diffuse optical tomography (DOT) imaging instrument which collects spatially dense, multispectral, frequency-domain breast data in the parallel-plate geometry. Methods: The instrument utilizes a CCD-based heterodyne detection scheme that permits massively parallel detection of diffuse photon density wave amplitude and phase for a large number of source–detector pairs (10{sup 6}). The stand-alone clinical DOT instrument thus offers high spatial resolution with reduced crosstalk between absorption and scattering. Other novel features include a fringe profilometry system for breast boundary segmentation, real-time data normalization, and a patient bed design which permits both axial and sagittalmore » breast measurements. Results: The authors validated the instrument using tissue simulating phantoms with two different chromophore-containing targets and one scattering target. The authors also demonstrated the instrument in a case study breast cancer patient; the reconstructed 3D image of endogenous chromophores and scattering gave tumor localization in agreement with MRI. Conclusions: Imaging with a novel parallel-plate DOT breast imager that employs highly parallel, high-resolution CCD detection in the frequency-domain was demonstrated.« less

Rapid detection of HLA-B*51 by real-time polymerase chain reaction and high-resolution melting analysis.

PubMed

Imperiali, C; Alía-Ramos, P; Padró-Miquel, A

2015-08-01

HLA-B*51, a class I human leukocyte antigen (HLA) molecule, is the strongest known genetic risk factor for Behçet disease. However, there are only few articles reporting methods to determine the presence or absence of HLA-B51. For this reason, we designed and developed an easy, fast, and inexpensive real-time high-resolution melting (HRM) assay to detect HLA-B*51. We genotyped 61 samples by our HRM assay and by conventional polymerase chain reaction, and no discrepancies were found between results. Besides, a subgroup of 25 samples was also genotyped in a different laboratory, and another subgroup of 16 samples was obtained from the International Histocompatibility Working Group DNA Bank, and a full concordance of results was observed with those obtained by HRM. Regarding the identifying system evaluated, we obtained 100% of specificity, sensibility, and repeatability, and 0% of false positive and false negative rates. Therefore, this HRM analysis is easily applicable to the rapid detection of HLA-B*51, exhibits a high speed, and requires a very low budget. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Improving PET spatial resolution and detectability for prostate cancer imaging

NASA Astrophysics Data System (ADS)

Bal, H.; Guerin, L.; Casey, M. E.; Conti, M.; Eriksson, L.; Michel, C.; Fanti, S.; Pettinato, C.; Adler, S.; Choyke, P.

2014-08-01

Prostate cancer, one of the most common forms of cancer among men, can benefit from recent improvements in positron emission tomography (PET) technology. In particular, better spatial resolution, lower noise and higher detectability of small lesions could be greatly beneficial for early diagnosis and could provide a strong support for guiding biopsy and surgery. In this article, the impact of improved PET instrumentation with superior spatial resolution and high sensitivity are discussed, together with the latest development in PET technology: resolution recovery and time-of-flight reconstruction. Using simulated cancer lesions, inserted in clinical PET images obtained with conventional protocols, we show that visual identification of the lesions and detectability via numerical observers can already be improved using state of the art PET reconstruction methods. This was achieved using both resolution recovery and time-of-flight reconstruction, and a high resolution image with 2 mm pixel size. Channelized Hotelling numerical observers showed an increase in the area under the LROC curve from 0.52 to 0.58. In addition, a relationship between the simulated input activity and the area under the LROC curve showed that the minimum detectable activity was reduced by more than 23%.

Non-Intrusive Magneto-Optic Detecting System for Investigations of Air Switching Arcs

NASA Astrophysics Data System (ADS)

Zhang, Pengfei; Zhang, Guogang; Dong, Jinlong; Liu, Wanying; Geng, Yingsan

2014-07-01

In current investigations of electric arc plasmas, experiments based on modern testing technology play an important role. To enrich the testing methods and contribute to the understanding and grasping of the inherent mechanism of air switching arcs, in this paper, a non-intrusive detecting system is described that combines the magneto-optic imaging (MOI) technique with the solution to inverse electromagnetic problems. The detecting system works in a sequence of main steps as follows: MOI of the variation of the arc flux density over a plane, magnetic field information extracted from the magneto-optic (MO) images, arc current density distribution and spatial pattern reconstruction by inverting the resulting field data. Correspondingly, in the system, an MOI set-up is designed based on the Faraday effect and the polarization properties of light, and an intelligent inversion algorithm is proposed that involves simulated annealing (SA). Experiments were carried out for high current (2 kA RMS) discharge cases in a typical low-voltage switchgear. The results show that the MO detection system possesses the advantages of visualization, high resolution and response, and electrical insulation, which provides a novel diagnostics tool for further studies of the arc.