Science.gov

Sample records for highly scalable trip

  1. High Scalability Video ISR Exploitation

    DTIC Science & Technology

    2012-10-01

    cloud computing, Hadoop , Map/Reduce, scene understanding, visual saliency, scalability, ISR, and Motion Intelligence (U) ABSTRACT (U) The...34 problem in large-scale text processing through cloud computing architectures like Apache Hadoop . Hadoop applies a parallel batch- processing paradigm...that reads data from multiple hard disks simultaneously called Map/Reduce. In contrast to Hadoop , Modern CV algorithms assume a sequential data stream

  2. Highly scalable coherent fiber combining

    NASA Astrophysics Data System (ADS)

    Antier, M.; Bourderionnet, J.; Larat, C.; Lallier, E.; Brignon, A.

    2015-10-01

    An architecture for active coherent fiber laser beam combining using an interferometric measurement is demonstrated. This technique allows measuring the exact phase errors of each fiber beam in a single shot. Therefore, this method is a promising candidate toward very large number of combined fibers. Our experimental system, composed of 16 independent fiber channels, is used to evaluate the achieved phase locking stability in terms of phase shift error and bandwidth. We show that only 8 pixels per fiber on the camera is required for a stable close loop operation with a residual phase error of λ/20 rms, which demonstrates the scalability of this concept. Furthermore we propose a beam shaping technique to increase the combining efficiency.

  3. Field Trips as Cognitive Motivators for High Level Science Learning

    ERIC Educational Resources Information Center

    Hurley, Marlene M.

    2006-01-01

    Using a composite example of field trips from several years of traveling to Yellowstone with high school biology students, the author illustrates how to raise the cognitive level of science instruction and student learning through science field trips. The author examines what teachers can do to raise the level of both teaching and learning in all…

  4. Scalable resource management in high performance computers.

    SciTech Connect

    Frachtenberg, E.; Petrini, F.; Fernandez Peinador, J.; Coll, S.

    2002-01-01

    Clusters of workstations have emerged as an important platform for building cost-effective, scalable and highly-available computers. Although many hardware solutions are available today, the largest challenge in making large-scale clusters usable lies in the system software. In this paper we present STORM, a resource management tool designed to provide scalability, low overhead and the flexibility necessary to efficiently support and analyze a wide range of job scheduling algorithms. STORM achieves these feats by closely integrating the management daemons with the low-level features that are common in state-of-the-art high-performance system area networks. The architecture of STORM is based on three main technical innovations. First, a sizable part of the scheduler runs in the thread processor located on the network interface. Second, we use hardware collectives that are highly scalable both for implementing control heartbeats and to distribute the binary of a parallel job in near-constant time, irrespective of job and machine sizes. Third, we use an I/O bypass protocol that allows fast data movements from the file system to the communication buffers in the network interface and vice versa. The experimental results show that STORM can launch a job with a binary of 12MB on a 64 processor/32 node cluster in less than 0.25 sec on an empty network, in less than 0.45 sec when all the processors are busy computing other jobs, and in less than 0.65 sec when the network is flooded with a background traffic. This paper provides experimental and analytical evidence that these results scale to a much larger number of nodes. To the best of our knowledge, STORM is at least two orders of magnitude faster than existing production schedulers in launching jobs, performing resource management tasks and gang scheduling.

  5. The high-speed deformation behavior of TRIP steels

    NASA Astrophysics Data System (ADS)

    Choi, Ildong; Bruce, Denise M.; Matlock, David K.; Speer, John G.

    2008-04-01

    The high-speed deformation behavior of TRIP steel was investigated at strain rates ranging from 10-2 s-1 to 103 s-1. The effects of metallurgical factors, such as the rolling direction, thickness, and gage length, on the tensile properties at various strain rates were evaluated. The ultimate tensile strength, uniform elongation, strain rate sensitivity, absorbed energy, and strain-hardening exponent are reported. In general, the strength increases and the ductility decreases as the strain rate increases. The samples with a high amount of retained austenite had two distinct regions of strain rate sensitivity, showing high strain rate sensitivity over a strain rate of 102 s-1. The tensile properties were not affected by the gage length and thickness of the tensile samples; however, the rolling direction of the tensile samples affected the UTS values slightly. The absorbed energy of the TRIP steel greatly exceeded that of HSLA steel.

  6. Highly Scalable Matching Pursuit Signal Decomposition Algorithm

    NASA Technical Reports Server (NTRS)

    Christensen, Daniel; Das, Santanu; Srivastava, Ashok N.

    2009-01-01

    Matching Pursuit Decomposition (MPD) is a powerful iterative algorithm for signal decomposition and feature extraction. MPD decomposes any signal into linear combinations of its dictionary elements or atoms . A best fit atom from an arbitrarily defined dictionary is determined through cross-correlation. The selected atom is subtracted from the signal and this procedure is repeated on the residual in the subsequent iterations until a stopping criterion is met. The reconstructed signal reveals the waveform structure of the original signal. However, a sufficiently large dictionary is required for an accurate reconstruction; this in return increases the computational burden of the algorithm, thus limiting its applicability and level of adoption. The purpose of this research is to improve the scalability and performance of the classical MPD algorithm. Correlation thresholds were defined to prune insignificant atoms from the dictionary. The Coarse-Fine Grids and Multiple Atom Extraction techniques were proposed to decrease the computational burden of the algorithm. The Coarse-Fine Grids method enabled the approximation and refinement of the parameters for the best fit atom. The ability to extract multiple atoms within a single iteration enhanced the effectiveness and efficiency of each iteration. These improvements were implemented to produce an improved Matching Pursuit Decomposition algorithm entitled MPD++. Disparate signal decomposition applications may require a particular emphasis of accuracy or computational efficiency. The prominence of the key signal features required for the proper signal classification dictates the level of accuracy necessary in the decomposition. The MPD++ algorithm may be easily adapted to accommodate the imposed requirements. Certain feature extraction applications may require rapid signal decomposition. The full potential of MPD++ may be utilized to produce incredible performance gains while extracting only slightly less energy than the

  7. Scalable photonic crystal chips for high sensitivity protein detection.

    PubMed

    Liang, Feng; Clarke, Nigel; Patel, Parth; Loncar, Marko; Quan, Qimin

    2013-12-30

    Scalable microfabrication technology has enabled semiconductor and microelectronics industries, among other fields. Meanwhile, rapid and sensitive bio-molecule detection is increasingly important for drug discovery and biomedical diagnostics. In this work, we designed and demonstrated that photonic crystal sensor chips have high sensitivity for protein detection and can be mass-produced with scalable deep-UV lithography. We demonstrated label-free detection of carcinoembryonic antigen from pg/mL to μg/mL, with high quality factor photonic crystal nanobeam cavities.

  8. Technical Report: Scalable Parallel Algorithms for High Dimensional Numerical Integration

    SciTech Connect

    Masalma, Yahya; Jiao, Yu

    2010-10-01

    We implemented a scalable parallel quasi-Monte Carlo numerical high-dimensional integration for tera-scale data points. The implemented algorithm uses the Sobol s quasi-sequences to generate random samples. Sobol s sequence was used to avoid clustering effects in the generated random samples and to produce low-discrepancy random samples which cover the entire integration domain. The performance of the algorithm was tested. Obtained results prove the scalability and accuracy of the implemented algorithms. The implemented algorithm could be used in different applications where a huge data volume is generated and numerical integration is required. We suggest using the hyprid MPI and OpenMP programming model to improve the performance of the algorithms. If the mixed model is used, attention should be paid to the scalability and accuracy.

  9. Low power, scalable multichannel high voltage controller

    DOEpatents

    Stamps, James Frederick; Crocker, Robert Ward; Yee, Daniel Dadwa; Dils, David Wright

    2008-03-25

    A low voltage control circuit is provided for individually controlling high voltage power provided over bus lines to a multitude of interconnected loads. An example of a load is a drive for capillary channels in a microfluidic system. Control is distributed from a central high voltage circuit, rather than using a number of large expensive central high voltage circuits to enable reducing circuit size and cost. Voltage is distributed to each individual load and controlled using a number of high voltage controller channel switches connected to high voltage bus lines. The channel switches each include complementary pull up and pull down photo isolator relays with photo isolator switching controlled from the central high voltage circuit to provide a desired bus line voltage. Switching of the photo isolator relays is further controlled in each channel switch using feedback from a resistor divider circuit to maintain the bus voltage swing within desired limits. Current sensing is provided using a switched resistive load in each channel switch, with switching of the resistive loads controlled from the central high voltage circuit.

  10. Low power, scalable multichannel high voltage controller

    DOEpatents

    Stamps, James Frederick; Crocker, Robert Ward; Yee, Daniel Dadwa; Dils, David Wright

    2006-03-14

    A low voltage control circuit is provided for individually controlling high voltage power provided over bus lines to a multitude of interconnected loads. An example of a load is a drive for capillary channels in a microfluidic system. Control is distributed from a central high voltage circuit, rather than using a number of large expensive central high voltage circuits to enable reducing circuit size and cost. Voltage is distributed to each individual load and controlled using a number of high voltage controller channel switches connected to high voltage bus lines. The channel switches each include complementary pull up and pull down photo isolator relays with photo isolator switching controlled from the central high voltage circuit to provide a desired bus line voltage. Switching of the photo isolator relays is further controlled in each channel switch using feedback from a resistor divider circuit to maintain the bus voltage swing within desired limits. Current sensing is provided using a switched resistive load in each channel switch, with switching of the resistive loads controlled from the central high voltage circuit.

  11. Influence of original microstructure on the transformation behavior and mechanical properties of ultra-high-strength TRIP-aided steel

    NASA Astrophysics Data System (ADS)

    Yin, Hong-xiang; Zhao, Ai-min; Zhao, Zheng-zhi; Li, Xiao; Li, Shuang-jiao; Hu, Han-jiang; Xia, Wei-guang

    2015-03-01

    The transformation behavior and tensile properties of an ultra-high-strength transformation-induced plasticity (TRIP) steel (0.2C-2.0Si-1.8Mn) were investigated by different heat treatments for automobile applications. The results show that F-TRIP steel, a traditional TRIP steel containing as-cold-rolled ferrite and pearlite as the original microstructure, consists of equiaxed grains of intercritical ferrite surrounded by discrete particles of M/RA and B. In contrast, M-TRIP steel, a modified TRIP-aided steel with martensite as the original microstructure, containing full martensite as the original microstructure is comprised of lath-shaped grains of ferrite separated by lath-shaped martensite/retained austenite and bainite. Most of the austenite in F-TRIP steel is granular, while the austenite in M-TRIP steel is lath-shaped. The volume fraction of the retained austenite as well as its carbon content is lower in F-TRIP steel than in M-TRIP steel, and austenite grains in M-TRIP steel are much finer than those in F-TRIP steel. Therefore, M-TRIP steel was concluded to have a higher austenite stability, resulting in a lower transformation rate and consequently contributing to a higher elongation compared to F-TRIP steel. Work hardening behavior is also discussed for both types of steel.

  12. A Highly Scalable Peptide-Based Assay System for Proteomics

    PubMed Central

    Kozlov, Igor A.; Thomsen, Elliot R.; Munchel, Sarah E.; Villegas, Patricia; Capek, Petr; Gower, Austin J.; K. Pond, Stephanie J.; Chudin, Eugene; Chee, Mark S.

    2012-01-01

    We report a scalable and cost-effective technology for generating and screening high-complexity customizable peptide sets. The peptides are made as peptide-cDNA fusions by in vitro transcription/translation from pools of DNA templates generated by microarray-based synthesis. This approach enables large custom sets of peptides to be designed in silico, manufactured cost-effectively in parallel, and assayed efficiently in a multiplexed fashion. The utility of our peptide-cDNA fusion pools was demonstrated in two activity-based assays designed to discover protease and kinase substrates. In the protease assay, cleaved peptide substrates were separated from uncleaved and identified by digital sequencing of their cognate cDNAs. We screened the 3,011 amino acid HCV proteome for susceptibility to cleavage by the HCV NS3/4A protease and identified all 3 known trans cleavage sites with high specificity. In the kinase assay, peptide substrates phosphorylated by tyrosine kinases were captured and identified by sequencing of their cDNAs. We screened a pool of 3,243 peptides against Abl kinase and showed that phosphorylation events detected were specific and consistent with the known substrate preferences of Abl kinase. Our approach is scalable and adaptable to other protein-based assays. PMID:22701568

  13. Scalable Multiprocessor for High-Speed Computing in Space

    NASA Technical Reports Server (NTRS)

    Lux, James; Lang, Minh; Nishimoto, Kouji; Clark, Douglas; Stosic, Dorothy; Bachmann, Alex; Wilkinson, William; Steffke, Richard

    2004-01-01

    A report discusses the continuing development of a scalable multiprocessor computing system for hard real-time applications aboard a spacecraft. "Hard realtime applications" signifies applications, like real-time radar signal processing, in which the data to be processed are generated at "hundreds" of pulses per second, each pulse "requiring" millions of arithmetic operations. In these applications, the digital processors must be tightly integrated with analog instrumentation (e.g., radar equipment), and data input/output must be synchronized with analog instrumentation, controlled to within fractions of a microsecond. The scalable multiprocessor is a cluster of identical commercial-off-the-shelf generic DSP (digital-signal-processing) computers plus generic interface circuits, including analog-to-digital converters, all controlled by software. The processors are computers interconnected by high-speed serial links. Performance can be increased by adding hardware modules and correspondingly modifying the software. Work is distributed among the processors in a parallel or pipeline fashion by means of a flexible master/slave control and timing scheme. Each processor operates under its own local clock; synchronization is achieved by broadcasting master time signals to all the processors, which compute offsets between the master clock and their local clocks.

  14. Simulation analysis of Maanshan steam generator level high-high transient due to reactor coolant pump trip and restart

    SciTech Connect

    Lee, Shawcuang; Wang, Jyhgang; Lee, Heikuang; King, Chuanheng

    1990-06-01

    On March 21, 1989, the reactor coolant pump (RCP) of Maanshan nuclear power plant unit 1 was tripped so that the power output of loop 1 decreased to almost zero. After this short transient, the unit 1 reactor remained in steady-state operation and maintained 19% of rated power with only two loops (two RCPs). The problem of RCP-A was then resolved, and it was restarted at {approximately} 30 min after the prior trip. After 11 s, a water-level transient occurred in steam generator (SG)-A, and shortly thereafter the turbine and generator were automatically tripped because of the SG-A high-high level setpoint. At that point, because of another electrical system failure, the electrical bus could not automatically switch over the RCP power supply to off-site power so that all three RCPs were tripped because of a low-voltage signal. The resulted in a reactor trip. In this study, the Institute of Nuclear Energy Research was requested to analyze the scenario of the Maanshan nuclear power plant unit 1 SG-A high-high level transient event, which was induced by RCP-A restart after an accidental trip.

  15. High-performance, scalable optical network-on-chip architectures

    NASA Astrophysics Data System (ADS)

    Tan, Xianfang

    The rapid advance of technology enables a large number of processing cores to be integrated into a single chip which is called a Chip Multiprocessor (CMP) or a Multiprocessor System-on-Chip (MPSoC) design. The on-chip interconnection network, which is the communication infrastructure for these processing cores, plays a central role in a many-core system. With the continuously increasing complexity of many-core systems, traditional metallic wired electronic networks-on-chip (NoC) became a bottleneck because of the unbearable latency in data transmission and extremely high energy consumption on chip. Optical networks-on-chip (ONoC) has been proposed as a promising alternative paradigm for electronic NoC with the benefits of optical signaling communication such as extremely high bandwidth, negligible latency, and low power consumption. This dissertation focus on the design of high-performance and scalable ONoC architectures and the contributions are highlighted as follow: 1. A micro-ring resonator (MRR)-based Generic Wavelength-routed Optical Router (GWOR) is proposed. A method for developing any sized GWOR is introduced. GWOR is a scalable non-blocking ONoC architecture with simple structure, low cost and high power efficiency compared to existing ONoC designs. 2. To expand the bandwidth and improve the fault tolerance of the GWOR, a redundant GWOR architecture is designed by cascading different type of GWORs into one network. 3. The redundant GWOR built with MRR-based comb switches is proposed. Comb switches can expand the bandwidth while keep the topology of GWOR unchanged by replacing the general MRRs with comb switches. 4. A butterfly fat tree (BFT)-based hybrid optoelectronic NoC (HONoC) architecture is developed in which GWORs are used for global communication and electronic routers are used for local communication. The proposed HONoC uses less numbers of electronic routers and links than its counterpart of electronic BFT-based NoC. It takes the advantages of

  16. Towards ultra-high ductility TRIP-assisted multiphase steels controlled by strain gradient plasticity effects

    NASA Astrophysics Data System (ADS)

    Hatami, M. K.; Pardoen, T.; Lacroix, G.; Berke, P.; Jacques, P. J.; Massart, T. J.

    2017-01-01

    TRansformation Induced Plasticity (TRIP) is a very effective mechanism to increase the strain hardening capacity of multiphase steels containing a fraction of metastable austenite, leading to both high strength and large uniform elongation. Excellent performances have been reached in the past 20 years, with recent renewed interest through the development of the 3rd generation of high strength steels often involving a TRIP effect. The microstructure and composition optimization is complex due to the interplay of coupled effects on the transformation kinetics and work hardening such as phase stability, size of retained austenite grains, temperature and loading path. In particular, recent studies have shown that the TRIP effect can only be quantitatively captured for realistic microstructures if strain gradient plasticity effects are taken into account, although direct experimental validation of this claim is missing. Here, an original computational averaging scheme is developed for predicting the elastoplastic response of TRIP aided multiphase steels based on a strain gradient plasticity model. The microstructure is represented by an aggregate of many elementary unit cells involving each a fraction of retained austenite with a specified stability. The model parameters, involving the transformation kinetics, are identified based on experimental tensile tests performed at different temperatures. The model is further assessed towards original experiments, involving temperature changes during deformation. A classical size independent plasticity model is shown unable to capture the TRIP effect on the mechanical response. Conversely, the strain gradient formulation properly predicts substantial variations of the strain hardening with deformation and temperature, hence of the uniform elongation in good agreement with the experiments. A parametric study is performed to get more insight on the effect of the material length scale as well as to determine optimum transformation

  17. A scalable approach for high throughput branch flow filtration.

    PubMed

    Inglis, David W; Herman, Nick

    2013-05-07

    Microfluidic continuous flow filtration methods have the potential for very high size resolution using minimum feature sizes that are larger than the separation size, thereby circumventing the problem of clogging. Branch flow filtration is particularly promising because it has an unlimited dynamic range (ratio of largest passable particle to the smallest separated particle) but suffers from very poor volume throughput because when many branches are used, they cannot be identical if each is to have the same size cut-off. We describe a new iterative approach to the design of branch filtration devices able to overcome this limitation without large dead volumes. This is demonstrated by numerical modelling, fabrication and testing of devices with 20 branches, with dynamic ranges up to 6.9, and high filtration ratios (14-29%) on beads and fungal spores. The filters have a sharp size cutoff (10× depletion for 12% size difference), with large particle rejection equivalent to a 20th order Butterworth low pass filter. The devices are fully scalable, enabling higher throughput and smaller cutoff sizes and they are compatible with ultra low cost fabrication.

  18. High Performance Storage System Scalability: Architecture, Implementation, and Experience

    SciTech Connect

    Watson, R W

    2005-01-05

    The High Performance Storage System (HPSS) provides scalable hierarchical storage management (HSM), archive, and file system services. Its design, implementation and current dominant use are focused on HSM and archive services. It is also a general-purpose, global, shared, parallel file system, potentially useful in other application domains. When HPSS design and implementation began over a decade ago, scientific computing power and storage capabilities at a site, such as a DOE national laboratory, was measured in a few 10s of gigaops, data archived in HSMs in a few 10s of terabytes at most, data throughput rates to an HSM in a few megabytes/s, and daily throughput with the HSM in a few gigabytes/day. At that time, the DOE national laboratories and IBM HPSS design team recognized that we were headed for a data storage explosion driven by computing power rising to teraops/petaops requiring data stored in HSMs to rise to petabytes and beyond, data transfer rates with the HSM to rise to gigabytes/s and higher, and daily throughput with a HSM in 10s of terabytes/day. This paper discusses HPSS architectural, implementation and deployment experiences that contributed to its success in meeting the above orders of magnitude scaling targets. We also discuss areas that need additional attention as we continue significant scaling into the future.

  19. Local shear texture formation in adiabatic shear bands by high rate compression of high manganese TRIP steels

    NASA Astrophysics Data System (ADS)

    Li, J.; Yang, P.; Mao, W. M.; Cui, F. E.

    2015-04-01

    Local shear textures in ASBs of high manganese TRIP steels under high rate straining are determined and the influences of initial microstructure is analyzed using EBSD technique. It is seen that even at the presence of majority of two types of martensite before deformation, ASB is preferred to evolve in austenite, rather than in martenite, due to reverse transformation. Ultrafine grains of thress phases due to dynamic recrystallization are formed and all show shear textures. The less ε-martensite in ASB is distributed as islands and its preferred orientation can be found to originate from the variants in matrix. The grain orientation rotation around ASB in multi-phase alloy reveals significant influence of α'- martensite on texture in ASB. The mechanism of local texture formation in ASB of high manganese TRIP steel is proposed in terms of the interaction of early TRIP and later reverse transformation.

  20. Providing scalable system software for high-end simulations

    SciTech Connect

    Greenberg, D.

    1997-12-31

    Detailed, full-system, complex physics simulations have been shown to be feasible on systems containing thousands of processors. In order to manage these computer systems it has been necessary to create scalable system services. In this talk Sandia`s research on scalable systems will be described. The key concepts of low overhead data movement through portals and of flexible services through multi-partition architectures will be illustrated in detail. The talk will conclude with a discussion of how these techniques can be applied outside of the standard monolithic MPP system.

  1. Predicting Fracture Toughness of TRIP 800 using Phase Properties Characterized by In-Situ High Energy X-Ray Diffraction

    SciTech Connect

    Soulami, Ayoub; Choi, Kyoo Sil; Liu, Wenning N.; Sun, Xin; Khaleel, Mohammad A.; Ren, Yang; Wang, Yan-Dong

    2010-05-01

    TRansformation Induced Plasticity (TRIP) steel is a typical representative of 1st generation advanced high strength steel (AHSS) which exhibits a combination of high strength and excellent ductility due to its multiphase microstructure. In this paper, we study the crack propagation behavior and fracture resistance of a TRIP 800 steel using a microstructure-based finite element method with the various phase properties characterized by in-situ high energy Xray diffraction (HEXRD) technique. Uniaxial tensile tests on the notched TRIP 800 sheet specimens were also conducted, and the experimentally measured tensile properties and R-curves (Resistance curves) were used to calibrate the modeling parameters and to validate the overall modeling results. The comparison between the simulated and experimentally measured results suggests that the micromechanics based modeling procedure can well capture the overall complex crack propagation behaviors and the fracture resistance of TRIP steels. The methodology adopted here may be used to estimate the fracture resistance of various multiphase materials.

  2. Boundary Layer Transition and Trip Effectiveness on an Apollo Capsule in the JAXA High Enthalpy Shock Tunnel (HIEST) Facility

    NASA Technical Reports Server (NTRS)

    Kirk, Lindsay C.; Lillard, Randolph P.; Olejniczak, Joseph; Tanno, Hideyuki

    2015-01-01

    Computational assessments were performed to size boundary layer trips for a scaled Apollo capsule model in the High Enthalpy Shock Tunnel (HIEST) facility at the JAXA Kakuda Space Center in Japan. For stagnation conditions between 2 MJ/kg and 20 MJ/kg and between 10 MPa and 60 MPa, the appropriate trips were determined to be between 0.2 mm and 1.3 mm high, which provided kappa/delta values on the heatshield from 0.15 to 2.25. The tripped configuration consisted of an insert with a series of diamond shaped trips along the heatshield downstream of the stagnation point. Surface heat flux measurements were obtained on a capsule with a 250 mm diameter, 6.4% scale model, and pressure measurements were taken at axial stations along the nozzle walls. At low enthalpy conditions, the computational predictions agree favorably to the test data along the heatshield centerline. However, agreement becomes less favorable as the enthalpy increases conditions. The measured surface heat flux on the heatshield from the HIEST facility was under-predicted by the computations in these cases. Both smooth and tripped configurations were tested for comparison, and a post-test computational analysis showed that kappa/delta values based on the as-measured stagnation conditions ranged between 0.5 and 1.2. Tripped configurations for both 0.6 mm and 0.8 mm trip heights were able to effectively trip the flow to fully turbulent for a range of freestream conditions.

  3. Trade, TRIPS, and pharmaceuticals.

    PubMed

    Smith, Richard D; Correa, Carlos; Oh, Cecilia

    2009-02-21

    The World Trade Organization's Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS) set global minimum standards for the protection of intellectual property, substantially increasing and expanding intellectual-property rights, and generated clear gains for the pharmaceutical industry and the developed world. The question of whether TRIPS generates gains for developing countries, in the form of increased exports, is addressed in this paper through consideration of the importance of pharmaceuticals in health-care trade, outlining the essential requirements, implications, and issues related to TRIPS, and TRIPS-plus, in which increased restrictions are imposed as part of bilateral free-trade agreements. TRIPS has not generated substantial gains for developing countries, but has further increased pharmaceutical trade in developed countries. The unequal trade between developed and developing countries (ie, exporting and importing high-value patented drugs, respectively) raises the issue of access to medicines, which is exacerbated by TRIPS-plus provisions, although many countries have not even enacted provision for TRIPS flexibilities. Therefore this paper focuses on options that are available to the health community for negotiation to their advantage under TRIPS, and within the presence of TRIPS-plus.

  4. Science Activities for School Trips.

    ERIC Educational Resources Information Center

    Quint, Walter C.

    1980-01-01

    Describes ways in which physics-learning activity packets can be used by high school students participating in trips organized by other departments. Provides an example of physics activities incorporated into an airplane trip to Disney World. (CS)

  5. Galvanizability of Advanced High-Strength Steels 1180TRIP and 1180CP

    NASA Astrophysics Data System (ADS)

    Kim, M. S.; Kwak, J. H.; Kim, J. S.; Liu, Y. H.; Gao, N.; Tang, N.-Y.

    2009-08-01

    In general, Si-bearing advanced high-strength steels (AHSS) possess excellent mechanical properties but poor galvanizability. The galvanizability of a transformation-induced plasticity (TRIP) steel 1180TRIP containing 2.2 pct Mn and 1.7 pct Si and a complex phase steel 1180CP containing 2.7 pct Mn and 0.2 pct Si was extensively studied using a galvanizing simulator. The steel coupons were annealed at fixed dew points in the simulator. The surface features of the as-annealed steel coupons, together with galvanized and galvannealed coatings, were carefully examined using a variety of advanced analysis techniques. It was found that various oxides formed on the surface of these steels, depending on the steel composition and on the dew point control. Coating quality was good at 0 °C dew point but deteriorated as the dew point decreased to -35 °C and -65 °C. Based on the findings, guidance was provided for improving galvanizability by adjusting the Mn:Si ratio in steel compositions according to the dew point.

  6. A highly scalable, interoperable clinical decision support service

    PubMed Central

    Goldberg, Howard S; Paterno, Marilyn D; Rocha, Beatriz H; Schaeffer, Molly; Wright, Adam; Erickson, Jessica L; Middleton, Blackford

    2014-01-01

    Objective To create a clinical decision support (CDS) system that is shareable across healthcare delivery systems and settings over large geographic regions. Materials and methods The enterprise clinical rules service (ECRS) realizes nine design principles through a series of enterprise java beans and leverages off-the-shelf rules management systems in order to provide consistent, maintainable, and scalable decision support in a variety of settings. Results The ECRS is deployed at Partners HealthCare System (PHS) and is in use for a series of trials by members of the CDS consortium, including internally developed systems at PHS, the Regenstrief Institute, and vendor-based systems deployed at locations in Oregon and New Jersey. Performance measures indicate that the ECRS provides sub-second response time when measured apart from services required to retrieve data and assemble the continuity of care document used as input. Discussion We consider related work, design decisions, comparisons with emerging national standards, and discuss uses and limitations of the ECRS. Conclusions ECRS design, implementation, and use in CDS consortium trials indicate that it provides the flexibility and modularity needed for broad use and performs adequately. Future work will investigate additional CDS patterns, alternative methods of data passing, and further optimizations in ECRS performance. PMID:23828174

  7. Developing highly scalable fluid solvers for enabling multiphysics simulation.

    SciTech Connect

    Clausen, Jonathan R

    2013-03-01

    We performed an investigation into explicit algorithms for the simulation of incompressible flows using methods with a finite, but small amount of compressibility added. Such methods include the artificial compressibility method and the lattice-Boltzmann method. The impetus for investigating such techniques stems from the increasing use of parallel computation at all levels (processors, clusters, and graphics processing units). Explicit algorithms have the potential to leverage these resources. In our investigation, a new form of artificial compressibility was derived. This method, referred to as the Entropically Damped Artificial Compressibility (EDAC) method, demonstrated superior results to traditional artificial compressibility methods by damping the numerical acoustic waves associated with these methods. Performance nearing that of the lattice- Boltzmann technique was observed, without the requirement of recasting the problem in terms of particle distribution functions; continuum variables may be used. Several example problems were investigated using a finite-di erence and finite-element discretizations of the EDAC equations. Example problems included lid-driven cavity flow, a convecting Taylor-Green vortex, a doubly periodic shear layer, freely decaying turbulence, and flow over a square cylinder. Additionally, a scalability study was performed using in excess of one million processing cores. Explicit methods were found to have desirable scaling properties; however, some robustness and general applicability issues remained.

  8. Forest Field Trips among High School Science Teachers in the Southern Piedmont

    ERIC Educational Resources Information Center

    McCabe, Shannon M.; Munsell, John F.; Seiler, John R.

    2014-01-01

    Students benefit in many ways by taking field trips to forests. Improved academic performance, increased participation in outdoor recreation, and a better grasp of natural resources management are some of the advantages. However, trips are not easy for teachers to organize and lead. Declining budgets, on-campus schedules, and standards of learning…

  9. Vertical nanowire electrode array: a highly scalable platform for intracellular interfacing to neuronal circuits

    NASA Astrophysics Data System (ADS)

    Jorgolli, Marsela; Robinson, Jacob; Shalek, Alex; Yoon, Myung-Han; Gertner, Rona; Park, Hongkun

    2012-02-01

    Interrogation of complex neuronal network requires new experimental tools that are sensitive enough to quantify the strengths of synaptic connections, yet scalable enough to couple to a large number of neurons simultaneously. Here, we will present a new, highly scalable intracellular electrode platform based on vertical nanowires that affords parallel interfacing to multiple mammalian neurons. Specifically, we show that our vertical nanowire electrode arrays can intracellularly record and stimulate neuronal activity in dissociated cultures of rat cortical neurons and be used to map multiple individual synaptic connections. This platform's scalability and full compatibility with silicon nanofabrication techniques provide a clear path toward simultaneous high-fidelity interfacing with hundreds of individual neurons, opening up exciting new avenues for neuronal circuit studies and prosthetics.

  10. Highly defective graphite for scalable synthesis of nitrogen doped holey graphene with high volumetric capacitance

    NASA Astrophysics Data System (ADS)

    Zhang, Yijie; Ji, Lei; Li, Wanfei; Zhang, Zhao; Lu, Luhua; Zhou, Lisha; Liu, Jinghai; Chen, Ying; Liu, Liwei; Chen, Wei; Zhang, Yuegang

    2016-12-01

    Manipulating basal plane structure of graphene for advanced energy conversion materials design has been research frontier in recent years. By extending size of defects in the basal plane of graphene from atomic scale to nanoscale, graphene with in-plane holes can be synthesized by multiple steps oxidation and reduction of defective graphene oxide at low concentration. These complicated and low yield synthetic methods largely limited research and applications of holey graphene based high performance energy conversion materials. Inspired by graphene in-plane holes formation mechanism, an easy and scalable synthetic approach has been proposed in this work. By oxidizing widely available defective graphite mineral under high concentration, holey graphene oxide has been scalable synthesized. Through simple reduction of holey graphene oxide, nitrogen doped holey graphene with high volumetric capacitance of 439 F/cm3 was obtained. We believe this breakthrough can provide a feasible synthetic approach for further exploring the properties and performance of holey graphene based materials in variety of fields.

  11. TRIPPING CIRCUIT

    DOEpatents

    Lees, G.W.; McCormick, E.D.

    1962-05-22

    A tripping circuit employing a magnetic amplifier for tripping a reactor in response to power level, period, or instrument failure is described. A reference winding and signal winding are wound in opposite directions on the core. Current from an ion chamber passes through both windings. If the current increases at too fast a rate, a shunt circuit bypasses one or the windings and the amplifier output reverses polarity. (AEC)

  12. Development and Implementation of a Series of Laboratory Field Trips for Advanced High School Students to Connect Chemistry to Sustainability

    ERIC Educational Resources Information Center

    Aubrecht, Katherine B.; Padwa, Linda; Shen, Xiaoqi; Bazargan, Gloria

    2015-01-01

    We describe the content and organization of a series of day-long field trips to a university for high school students that connect chemistry content to issues of sustainability. The seven laboratory activities are in the areas of environmental degradation, energy production, and green chemistry. The laboratory procedures have been modified from…

  13. Scalable exfoliation process for highly soluble boron nitride nanoplatelets by hydroxide-assisted ball milling.

    PubMed

    Lee, Dongju; Lee, Bin; Park, Kwang Hyun; Ryu, Ho Jin; Jeon, Seokwoo; Hong, Soon Hyung

    2015-02-11

    The scalable preparation of two-dimensional hexagonal boron nitride (h-BN) is essential for practical applications. Despite intense research in this area, high-yield production of two-dimensional h-BN with large-size and high solubility remains a key challenge. In the present work, we propose a scalable exfoliation process for hydroxyl-functionalized BN nanoplatelets (OH-BNNPs) by a simple ball milling of BN powders in the presence of sodium hydroxide via the synergetic effect of chemical peeling and mechanical shear forces. The hydroxide-assisted ball milling process results in relatively large flakes with an average size of 1.5 μm with little damage to the in-plane structure of the OH-BNNP and high yields of 18%. The resultant OH-BNNP samples can be redispersed in various solvents and form stable dispersions that can be used for multiple purposes. The incorporation of the BNNPs into the polyethylene matrix effectively enhanced the barrier properties of the polyethylene due to increased tortuosity of the diffusion path of the gas molecules. Hydroxide-assisted ball milling process can thus provide simple and efficient approaches to scalable preparation of large-size and highly soluble BNNPs. Moreover, this exfoliation process is not only easily scalable but also applicable to other layered materials.

  14. Air-stable ink for scalable, high-throughput layer deposition

    DOEpatents

    Weil, Benjamin D; Connor, Stephen T; Cui, Yi

    2014-02-11

    A method for producing and depositing air-stable, easily decomposable, vulcanized ink on any of a wide range of substrates is disclosed. The ink enables high-volume production of optoelectronic and/or electronic devices using scalable production methods, such as roll-to-roll transfer, fast rolling processes, and the like.

  15. Scalable high-power and high-brightness fiber coupled diode laser devices

    NASA Astrophysics Data System (ADS)

    Köhler, Bernd; Ahlert, Sandra; Bayer, Andreas; Kissel, Heiko; Müntz, Holger; Noeske, Axel; Rotter, Karsten; Segref, Armin; Stoiber, Michael; Unger, Andreas; Wolf, Paul; Biesenbach, Jens

    2012-03-01

    The demand for high-power and high-brightness fiber coupled diode laser devices is mainly driven by applications for solid-state laser pumping and materials processing. The ongoing power scaling of fiber lasers requires scalable fibercoupled diode laser devices with increased power and brightness. For applications in materials processing multi-kW output power with beam quality of about 30 mm x mrad is needed. We have developed a modular diode laser concept combining high power, high brightness, wavelength stabilization and optionally low weight, which becomes more and more important for a multitude of applications. In particular the defense technology requires robust but lightweight high-power diode laser sources in combination with high brightness. Heart of the concept is a specially tailored diode laser bar, whose epitaxial and lateral structure is designed such that only standard fast- and slow-axis collimator lenses in combination with appropriate focusing optics are required to couple the beam into a fiber with a core diameter of 200 μm and a numerical aperture (NA) of 0.22. The spectral quality, which is an important issue especially for fiber laser pump sources, is ensured by means of Volume Holographic Gratings (VHG) for wavelength stabilization. In this paper we present a detailed characterization of different diode laser sources based on the scalable modular concept. The optical output power is scaled from 180 W coupled into a 100 μm NA 0.22 fiber up to 1.7 kW coupled into a 400 μm NA 0.22 fiber. In addition we present a lightweight laser unit with an output power of more than 300 W for a 200 μm NA 0.22 fiber with a weight vs. power ratio of only 0.9 kg/kW.

  16. Scalable High Performance Computing: Direct and Large-Eddy Turbulent Flow Simulations Using Massively Parallel Computers

    NASA Technical Reports Server (NTRS)

    Morgan, Philip E.

    2004-01-01

    This final report contains reports of research related to the tasks "Scalable High Performance Computing: Direct and Lark-Eddy Turbulent FLow Simulations Using Massively Parallel Computers" and "Devleop High-Performance Time-Domain Computational Electromagnetics Capability for RCS Prediction, Wave Propagation in Dispersive Media, and Dual-Use Applications. The discussion of Scalable High Performance Computing reports on three objectives: validate, access scalability, and apply two parallel flow solvers for three-dimensional Navier-Stokes flows; develop and validate a high-order parallel solver for Direct Numerical Simulations (DNS) and Large Eddy Simulation (LES) problems; and Investigate and develop a high-order Reynolds averaged Navier-Stokes turbulence model. The discussion of High-Performance Time-Domain Computational Electromagnetics reports on five objectives: enhancement of an electromagnetics code (CHARGE) to be able to effectively model antenna problems; utilize lessons learned in high-order/spectral solution of swirling 3D jets to apply to solving electromagnetics project; transition a high-order fluids code, FDL3DI, to be able to solve Maxwell's Equations using compact-differencing; develop and demonstrate improved radiation absorbing boundary conditions for high-order CEM; and extend high-order CEM solver to address variable material properties. The report also contains a review of work done by the systems engineer.

  17. On-demand high-capacity ride-sharing via dynamic trip-vehicle assignment.

    PubMed

    Alonso-Mora, Javier; Samaranayake, Samitha; Wallar, Alex; Frazzoli, Emilio; Rus, Daniela

    2017-01-17

    Ride-sharing services are transforming urban mobility by providing timely and convenient transportation to anybody, anywhere, and anytime. These services present enormous potential for positive societal impacts with respect to pollution, energy consumption, congestion, etc. Current mathematical models, however, do not fully address the potential of ride-sharing. Recently, a large-scale study highlighted some of the benefits of car pooling but was limited to static routes with two riders per vehicle (optimally) or three (with heuristics). We present a more general mathematical model for real-time high-capacity ride-sharing that (i) scales to large numbers of passengers and trips and (ii) dynamically generates optimal routes with respect to online demand and vehicle locations. The algorithm starts from a greedy assignment and improves it through a constrained optimization, quickly returning solutions of good quality and converging to the optimal assignment over time. We quantify experimentally the tradeoff between fleet size, capacity, waiting time, travel delay, and operational costs for low- to medium-capacity vehicles, such as taxis and van shuttles. The algorithm is validated with ∼3 million rides extracted from the New York City taxicab public dataset. Our experimental study considers ride-sharing with rider capacity of up to 10 simultaneous passengers per vehicle. The algorithm applies to fleets of autonomous vehicles and also incorporates rebalancing of idling vehicles to areas of high demand. This framework is general and can be used for many real-time multivehicle, multitask assignment problems.

  18. On-demand high-capacity ride-sharing via dynamic trip-vehicle assignment

    PubMed Central

    Alonso-Mora, Javier; Samaranayake, Samitha; Wallar, Alex; Frazzoli, Emilio; Rus, Daniela

    2017-01-01

    Ride-sharing services are transforming urban mobility by providing timely and convenient transportation to anybody, anywhere, and anytime. These services present enormous potential for positive societal impacts with respect to pollution, energy consumption, congestion, etc. Current mathematical models, however, do not fully address the potential of ride-sharing. Recently, a large-scale study highlighted some of the benefits of car pooling but was limited to static routes with two riders per vehicle (optimally) or three (with heuristics). We present a more general mathematical model for real-time high-capacity ride-sharing that (i) scales to large numbers of passengers and trips and (ii) dynamically generates optimal routes with respect to online demand and vehicle locations. The algorithm starts from a greedy assignment and improves it through a constrained optimization, quickly returning solutions of good quality and converging to the optimal assignment over time. We quantify experimentally the tradeoff between fleet size, capacity, waiting time, travel delay, and operational costs for low- to medium-capacity vehicles, such as taxis and van shuttles. The algorithm is validated with ∼3 million rides extracted from the New York City taxicab public dataset. Our experimental study considers ride-sharing with rider capacity of up to 10 simultaneous passengers per vehicle. The algorithm applies to fleets of autonomous vehicles and also incorporates rebalancing of idling vehicles to areas of high demand. This framework is general and can be used for many real-time multivehicle, multitask assignment problems. PMID:28049820

  19. WOMBAT: A Scalable and High-performance Astrophysical Magnetohydrodynamics Code

    NASA Astrophysics Data System (ADS)

    Mendygral, P. J.; Radcliffe, N.; Kandalla, K.; Porter, D.; O’Neill, B. J.; Nolting, C.; Edmon, P.; Donnert, J. M. F.; Jones, T. W.

    2017-02-01

    We present a new code for astrophysical magnetohydrodynamics specifically designed and optimized for high performance and scaling on modern and future supercomputers. We describe a novel hybrid OpenMP/MPI programming model that emerged from a collaboration between Cray, Inc. and the University of Minnesota. This design utilizes MPI-RMA optimized for thread scaling, which allows the code to run extremely efficiently at very high thread counts ideal for the latest generation of multi-core and many-core architectures. Such performance characteristics are needed in the era of “exascale” computing. We describe and demonstrate our high-performance design in detail with the intent that it may be used as a model for other, future astrophysical codes intended for applications demanding exceptional performance.

  20. LED light engine concept with ultra-high scalable luminance

    NASA Astrophysics Data System (ADS)

    Hoelen, Christoph; de Boer, Dick; Bruls, Dominique; van der Eyden, Joost; Koole, Rolf; Li, Yun; Mirsadeghi, Mo; Vanbroekhoven, Vincent; Van den Bergh, John-John; Van de Voorde, Patrick

    2016-03-01

    Although LEDs have been introduced successfully in many general lighting applications during the past decade, high brightness light source applications are still suffering from the limited luminance of LEDs. High power LEDs are generally limited in luminance to ca 100 Mnit (108 lm/m2sr) or less, while dedicated devices for projection may achieve luminance values up to ca 300 Mnit with phosphor converted green. In particular for high luminous flux applications with limited étendue, like in front projection systems, only very modest luminous flux values in the beam can be achieved with LEDs compared to systems based on discharge lamps. In this paper we introduce a light engine concept based on a light converter rod pumped with blue LEDs that breaks through the étendue and brightness limits of LEDs, enabling LED light source luminance values that are more than 4 times higher than what can be achieved with LEDs so far. In LED front projection systems, green LEDs are the main limiting factor. With our green light emitting modules, peak luminance values well above 1.2 Gnit have been achieved, enabling doubling of the screen brightness of LED based DLP projection systems, and even more when this technology is applied to other colors as well. This light source concept, introduced as the ColorSpark High Lumen Density (HLD) LED technology, enables a breakthrough in the performance of LED-based light engines not only for projection, where >2700 ANSI lm was demonstrated, but for a wide variety of high brightness applications.

  1. Efficient, Scalable Consistency for Highly Fault-Tolerant Storage

    DTIC Science & Technology

    2004-08-01

    Miguel Castro and Rodrigo Rodrigues for making the implementation of BFT publicly available. Contents 1 Introduction 1 1.1 Problem definition... Cabrera and Long 1991] cen- tralize access to a metadata server. IBM’s Storage Tank [Menon et al. 2003] and Lus- tre [Braam 2004] replace the central... CABRERA , L.-F. AND LONG, D. D. E. 1991. Swift: using distributed disk striping to provide high I/O data rates. Computing Systems 4, 4, 405–436

  2. Microstructures and Mechanical Properties of High-Mn TRIP Steel Based on Warm Deformation of Martensite

    NASA Astrophysics Data System (ADS)

    Guo, Zhikai; Li, Longfei; Yang, Wangyue; Sun, Zuqing

    2015-04-01

    High-Mn TRIP steel with about 5 wt pct Mn was prepared by a thermo-mechanical treatment based on warm deformation of martensite and subsequent short-time annealing in the intercritical region. The microstructural evolution and the mechanical properties of the used steel during such treatment were investigated. The results indicate that during warm deformation of martensite in the intercritical region, the decomposition of martensite was accelerated by warm deformation and the occurrence of dynamic recrystallization of ferrite led to the formation of equiaxed ferrite grains. Meanwhile, the reverse transformation of austenite was accelerated by warm deformation to some extent. During subsequent annealing in the intercritical region, static recrystallization of ferrite led to the increase in the fraction of equiaxed ferrite grains, and the formation of the reversed austenite was accelerated by the addition of the deformation-stored energy, while the stability of the reversed austenite was improved by the accelerated diffusions of C atoms and Mn atoms. As a whole, the mechanical properties of the used steel by the thermo-mechanical treatment based on warm deformation of martensite and subsequent short-time annealing in the intercritical region were comparable to the steels with similar compositions subjected to intercritical annealing for hours after cold rolling of martensite.

  3. Building and managing high performance, scalable, commodity mass storage systems

    NASA Technical Reports Server (NTRS)

    Lekashman, John

    1998-01-01

    The NAS Systems Division has recently embarked on a significant new way of handling the mass storage problem. One of the basic goals of this new development are to build systems at very large capacity and high performance, yet have the advantages of commodity products. The central design philosophy is to build storage systems the way the Internet was built. Competitive, survivable, expandable, and wide open. The thrust of this paper is to describe the motivation for this effort, what we mean by commodity mass storage, what the implications are for a facility that performs such an action, and where we think it will lead.

  4. Scalable Nearest Neighbor Algorithms for High Dimensional Data.

    PubMed

    Muja, Marius; Lowe, David G

    2014-11-01

    For many computer vision and machine learning problems, large training sets are key for good performance. However, the most computationally expensive part of many computer vision and machine learning algorithms consists of finding nearest neighbor matches to high dimensional vectors that represent the training data. We propose new algorithms for approximate nearest neighbor matching and evaluate and compare them with previous algorithms. For matching high dimensional features, we find two algorithms to be the most efficient: the randomized k-d forest and a new algorithm proposed in this paper, the priority search k-means tree. We also propose a new algorithm for matching binary features by searching multiple hierarchical clustering trees and show it outperforms methods typically used in the literature. We show that the optimal nearest neighbor algorithm and its parameters depend on the data set characteristics and describe an automated configuration procedure for finding the best algorithm to search a particular data set. In order to scale to very large data sets that would otherwise not fit in the memory of a single machine, we propose a distributed nearest neighbor matching framework that can be used with any of the algorithms described in the paper. All this research has been released as an open source library called fast library for approximate nearest neighbors (FLANN), which has been incorporated into OpenCV and is now one of the most popular libraries for nearest neighbor matching.

  5. Highly scalable digital front end architectures for digital printing

    NASA Astrophysics Data System (ADS)

    Staas, David

    2011-01-01

    HP's digital printing presses consume a tremendous amount of data. The architectures of the Digital Front Ends (DFEs) that feed these large, very fast presses have evolved from basic, single-RIP (Raster Image Processor) systems to multirack, distributed systems that can take a PDF file and deliver data in excess of 3 Gigapixels per second to keep the presses printing at 2000+ pages per minute. This paper highlights some of the more interesting parallelism features of our DFE architectures. The high-performance architecture developed over the last 5+ years can scale up to HP's largest digital press, out to multiple mid-range presses, and down into a very low-cost single box deployment for low-end devices as appropriate. Principles of parallelism pervade every aspect of the architecture, from the lowest-level elements of jobs to parallel imaging pipelines that feed multiple presses. From cores to threads to arrays to network teams to distributed machines, we use a systematic approach to move bottlenecks. The ultimate goals of these efforts are: to take the best advantage of the prevailing hardware options at our disposal; to reduce power consumption and cooling requirements; and to ultimately reduce the cost of the solution to our customers.

  6. Scalable, high performance, enzymatic cathodes based on nanoimprint lithography.

    PubMed

    Pankratov, Dmitry; Sundberg, Richard; Sotres, Javier; Suyatin, Dmitry B; Maximov, Ivan; Shleev, Sergey; Montelius, Lars

    2015-01-01

    Here we detail high performance, enzymatic electrodes for oxygen bio-electroreduction, which can be easily and reproducibly fabricated with industry-scale throughput. Planar and nanostructured electrodes were built on biocompatible, flexible polymer sheets, while nanoimprint lithography was used for electrode nanostructuring. To the best of our knowledge, this is one of the first reports concerning the usage of nanoimprint lithography for amperometric bioelectronic devices. The enzyme (Myrothecium verrucaria bilirubin oxidase) was immobilised on planar (control) and artificially nanostructured, gold electrodes by direct physical adsorption. The detailed electrochemical investigation of bioelectrodes was performed and the following parameters were obtained: open circuit voltage of approximately 0.75 V, and maximum bio-electrocatalytic current densities of 18 µA/cm(2) and 58 µA/cm(2) in air-saturated buffers versus 48 µA/cm(2) and 186 µA/cm(2) in oxygen-saturated buffers for planar and nanostructured electrodes, respectively. The half-deactivation times of planar and nanostructured biocathodes were measured to be 2 h and 14 h, respectively. The comparison of standard heterogeneous and bio-electrocatalytic rate constants showed that the improved bio-electrocatalytic performance of the nanostructured biocathodes compared to planar biodevices is due to the increased surface area of the nanostructured electrodes, whereas their improved operational stability is attributed to stabilisation of the enzyme inside nanocavities.

  7. Field Trip.

    ERIC Educational Resources Information Center

    Sanders, Bill

    1993-01-01

    Reports the results of a field trip to measure the intensity of electromagnetic fields generated by electronic devices in the home, in cars, at work, outside, and in places people visit during the day. Found that a person gets more intense exposure while working at a computer than by living next to an electrical substation. (MDH)

  8. Analysis of scalability of high-performance 3D image processing platform for virtual colonoscopy

    NASA Astrophysics Data System (ADS)

    Yoshida, Hiroyuki; Wu, Yin; Cai, Wenli

    2014-03-01

    One of the key challenges in three-dimensional (3D) medical imaging is to enable the fast turn-around time, which is often required for interactive or real-time response. This inevitably requires not only high computational power but also high memory bandwidth due to the massive amount of data that need to be processed. For this purpose, we previously developed a software platform for high-performance 3D medical image processing, called HPC 3D-MIP platform, which employs increasingly available and affordable commodity computing systems such as the multicore, cluster, and cloud computing systems. To achieve scalable high-performance computing, the platform employed size-adaptive, distributable block volumes as a core data structure for efficient parallelization of a wide range of 3D-MIP algorithms, supported task scheduling for efficient load distribution and balancing, and consisted of a layered parallel software libraries that allow image processing applications to share the common functionalities. We evaluated the performance of the HPC 3D-MIP platform by applying it to computationally intensive processes in virtual colonoscopy. Experimental results showed a 12-fold performance improvement on a workstation with 12-core CPUs over the original sequential implementation of the processes, indicating the efficiency of the platform. Analysis of performance scalability based on the Amdahl's law for symmetric multicore chips showed the potential of a high performance scalability of the HPC 3DMIP platform when a larger number of cores is available.

  9. Analysis of scalability of high-performance 3D image processing platform for virtual colonoscopy

    PubMed Central

    Yoshida, Hiroyuki; Wu, Yin; Cai, Wenli

    2014-01-01

    One of the key challenges in three-dimensional (3D) medical imaging is to enable the fast turn-around time, which is often required for interactive or real-time response. This inevitably requires not only high computational power but also high memory bandwidth due to the massive amount of data that need to be processed. For this purpose, we previously developed a software platform for high-performance 3D medical image processing, called HPC 3D-MIP platform, which employs increasingly available and affordable commodity computing systems such as the multicore, cluster, and cloud computing systems. To achieve scalable high-performance computing, the platform employed size-adaptive, distributable block volumes as a core data structure for efficient parallelization of a wide range of 3D-MIP algorithms, supported task scheduling for efficient load distribution and balancing, and consisted of a layered parallel software libraries that allow image processing applications to share the common functionalities. We evaluated the performance of the HPC 3D-MIP platform by applying it to computationally intensive processes in virtual colonoscopy. Experimental results showed a 12-fold performance improvement on a workstation with 12-core CPUs over the original sequential implementation of the processes, indicating the efficiency of the platform. Analysis of performance scalability based on the Amdahl’s law for symmetric multicore chips showed the potential of a high performance scalability of the HPC 3D-MIP platform when a larger number of cores is available. PMID:24910506

  10. Scalable Light Module for Low-Cost, High-Efficiency Light- Emitting Diode Luminaires

    SciTech Connect

    Tarsa, Eric

    2015-08-31

    During this two-year program Cree developed a scalable, modular optical architecture for low-cost, high-efficacy light emitting diode (LED) luminaires. Stated simply, the goal of this architecture was to efficiently and cost-effectively convey light from LEDs (point sources) to broad luminaire surfaces (area sources). By simultaneously developing warm-white LED components and low-cost, scalable optical elements, a high system optical efficiency resulted. To meet program goals, Cree evaluated novel approaches to improve LED component efficacy at high color quality while not sacrificing LED optical efficiency relative to conventional packages. Meanwhile, efficiently coupling light from LEDs into modular optical elements, followed by optimally distributing and extracting this light, were challenges that were addressed via novel optical design coupled with frequent experimental evaluations. Minimizing luminaire bill of materials and assembly costs were two guiding principles for all design work, in the effort to achieve luminaires with significantly lower normalized cost ($/klm) than existing LED fixtures. Chief project accomplishments included the achievement of >150 lm/W warm-white LEDs having primary optics compatible with low-cost modular optical elements. In addition, a prototype Light Module optical efficiency of over 90% was measured, demonstrating the potential of this scalable architecture for ultra-high-efficacy LED luminaires. Since the project ended, Cree has continued to evaluate optical element fabrication and assembly methods in an effort to rapidly transfer this scalable, cost-effective technology to Cree production development groups. The Light Module concept is likely to make a strong contribution to the development of new cost-effective, high-efficacy luminaries, thereby accelerating widespread adoption of energy-saving SSL in the U.S.

  11. Towards a highly-scalable wireless implantable system-on-a-chip for gastric electrophysiology.

    PubMed

    Ibrahim, Ahmed; Farajidavar, Aydin; Kiani, Mehdi

    2015-08-01

    This paper presents the system design of a highly-scalable system-on-a-chip (SoC) to wirelessly and chronically detect the mechanisms underlying gastric dysrhythmias. The proposed wireless implantable gastric-wave recording (WIGR) SoC records gastric slow-wave and spike activities from 256 sites, and establishes transcutaneous data communication with an external reader while being inductively powered. The SoC is highly scalable by employing a modular architecture for the analog front-end (AFE), a near-field pulse-delay modulation (PDM) data transmitter (Tx) that its data rate is proportional to the power carrier frequency (fp), and an adaptive power management equipped with automatic-resonance tuning (ART) that dynamically compensates for environmental and fp variations of the implant power coil. The simulation and measurement results for individual blocks have been presented.

  12. Volume-scalable high-brightness three-dimensional visible light source

    SciTech Connect

    Subramania, Ganapathi; Fischer, Arthur J; Wang, George T; Li, Qiming

    2014-02-18

    A volume-scalable, high-brightness, electrically driven visible light source comprises a three-dimensional photonic crystal (3DPC) comprising one or more direct bandgap semiconductors. The improved light emission performance of the invention is achieved based on the enhancement of radiative emission of light emitters placed inside a 3DPC due to the strong modification of the photonic density-of-states engendered by the 3DPC.

  13. TripAdvisor^{N-D}: A Tourism-Inspired High-Dimensional Space Exploration Framework with Overview and Detail.

    PubMed

    Nam, Julia EunJu; Mueller, Klaus

    2013-02-01

    Gaining a true appreciation of high-dimensional space remains difficult since all of the existing high-dimensional space exploration techniques serialize the space travel in some way. This is not so foreign to us since we, when traveling, also experience the world in a serial fashion. But we typically have access to a map to help with positioning, orientation, navigation, and trip planning. Here, we propose a multivariate data exploration tool that compares high-dimensional space navigation with a sightseeing trip. It decomposes this activity into five major tasks: 1) Identify the sights: use a map to identify the sights of interest and their location; 2) Plan the trip: connect the sights of interest along a specifyable path; 3) Go on the trip: travel along the route; 4) Hop off the bus: experience the location, look around, zoom into detail; and 5) Orient and localize: regain bearings in the map. We describe intuitive and interactive tools for all of these tasks, both global navigation within the map and local exploration of the data distributions. For the latter, we describe a polygonal touchpad interface which enables users to smoothly tilt the projection plane in high-dimensional space to produce multivariate scatterplots that best convey the data relationships under investigation. Motion parallax and illustrative motion trails aid in the perception of these transient patterns. We describe the use of our system within two applications: 1) the exploratory discovery of data configurations that best fit a personal preference in the presence of tradeoffs and 2) interactive cluster analysis via cluster sculpting in N-D.

  14. A robust and high-performance queue management controller for large round trip time networks

    NASA Astrophysics Data System (ADS)

    Khoshnevisan, Ladan; Salmasi, Farzad R.

    2016-05-01

    Congestion management for transmission control protocol is of utmost importance to prevent packet loss within a network. This necessitates strategies for active queue management. The most applied active queue management strategies have their inherent disadvantages which lead to suboptimal performance and even instability in the case of large round trip time and/or external disturbance. This paper presents an internal model control robust queue management scheme with two degrees of freedom in order to restrict the undesired effects of large and small round trip time and parameter variations in the queue management. Conventional approaches such as proportional integral and random early detection procedures lead to unstable behaviour due to large delay. Moreover, internal model control-Smith scheme suffers from large oscillations due to the large round trip time. On the other hand, other schemes such as internal model control-proportional integral and derivative show excessive sluggish performance for small round trip time values. To overcome these shortcomings, we introduce a system entailing two individual controllers for queue management and disturbance rejection, simultaneously. Simulation results based on Matlab/Simulink and also Network Simulator 2 (NS2) demonstrate the effectiveness of the procedure and verify the analytical approach.

  15. Scalable high-precision tuning of photonic resonators by resonant cavity-enhanced photoelectrochemical etching

    PubMed Central

    Gil-Santos, Eduardo; Baker, Christopher; Lemaître, Aristide; Gomez, Carmen; Leo, Giuseppe; Favero, Ivan

    2017-01-01

    Photonic lattices of mutually interacting indistinguishable cavities represent a cornerstone of collective phenomena in optics and could become important in advanced sensing or communication devices. The disorder induced by fabrication technologies has so far hindered the development of such resonant cavity architectures, while post-fabrication tuning methods have been limited by complexity and poor scalability. Here we present a new simple and scalable tuning method for ensembles of microphotonic and nanophotonic resonators, which enables their permanent collective spectral alignment. The method introduces an approach of cavity-enhanced photoelectrochemical etching in a fluid, a resonant process triggered by sub-bandgap light that allows for high selectivity and precision. The technique is presented on a gallium arsenide nanophotonic platform and illustrated by finely tuning one, two and up to five resonators. It opens the way to applications requiring large networks of identical resonators and their spectral referencing to external etalons. PMID:28117394

  16. Palacios and Kitten : high performance operating systems for scalable virtualized and native supercomputing.

    SciTech Connect

    Widener, Patrick; Jaconette, Steven; Bridges, Patrick G.; Xia, Lei; Dinda, Peter; Cui, Zheng.; Lange, John; Hudson, Trammell B.; Levenhagen, Michael J.; Pedretti, Kevin Thomas Tauke; Brightwell, Ronald Brian

    2009-09-01

    Palacios and Kitten are new open source tools that enable applications, whether ported or not, to achieve scalable high performance on large machines. They provide a thin layer over the hardware to support both full-featured virtualized environments and native code bases. Kitten is an OS under development at Sandia that implements a lightweight kernel architecture to provide predictable behavior and increased flexibility on large machines, while also providing Linux binary compatibility. Palacios is a VMM that is under development at Northwestern University and the University of New Mexico. Palacios, which can be embedded into Kitten and other OSes, supports existing, unmodified applications and operating systems by using virtualization that leverages hardware technologies. We describe the design and implementation of both Kitten and Palacios. Our benchmarks show that they provide near native, scalable performance. Palacios and Kitten provide an incremental path to using supercomputer resources that is not performance-compromised.

  17. Scalable high-precision tuning of photonic resonators by resonant cavity-enhanced photoelectrochemical etching

    NASA Astrophysics Data System (ADS)

    Gil-Santos, Eduardo; Baker, Christopher; Lemaître, Aristide; Gomez, Carmen; Leo, Giuseppe; Favero, Ivan

    2017-01-01

    Photonic lattices of mutually interacting indistinguishable cavities represent a cornerstone of collective phenomena in optics and could become important in advanced sensing or communication devices. The disorder induced by fabrication technologies has so far hindered the development of such resonant cavity architectures, while post-fabrication tuning methods have been limited by complexity and poor scalability. Here we present a new simple and scalable tuning method for ensembles of microphotonic and nanophotonic resonators, which enables their permanent collective spectral alignment. The method introduces an approach of cavity-enhanced photoelectrochemical etching in a fluid, a resonant process triggered by sub-bandgap light that allows for high selectivity and precision. The technique is presented on a gallium arsenide nanophotonic platform and illustrated by finely tuning one, two and up to five resonators. It opens the way to applications requiring large networks of identical resonators and their spectral referencing to external etalons.

  18. CGLX: a scalable, high-performance visualization framework for networked display environments.

    PubMed

    Doerr, Kai-Uwe; Kuester, Falko

    2011-03-01

    The Cross Platform Cluster Graphics Library (CGLX) is a flexible and transparent OpenGL-based graphics framework for distributed, high-performance visualization systems. CGLX allows OpenGL based applications to utilize massively scalable visualization clusters such as multiprojector or high-resolution tiled display environments and to maximize the achievable performance and resolution. The framework features a programming interface for hardware-accelerated rendering of OpenGL applications on visualization clusters, mimicking a GLUT-like (OpenGL-Utility-Toolkit) interface to enable smooth translation of single-node applications to distributed parallel rendering applications. CGLX provides a unified, scalable, distributed OpenGL context to the user by intercepting and manipulating certain OpenGL directives. CGLX's interception mechanism, in combination with the core functionality for users to register callbacks, enables this framework to manage a visualization grid without additional implementation requirements to the user. Although CGLX grants access to its core engine, allowing users to change its default behavior, general development can occur in the context of a standalone desktop. The framework provides an easy-to-use graphical user interface (GUI) and tools to test, setup, and configure a visualization cluster. This paper describes CGLX's architecture, tools, and systems components. We present performance and scalability tests with different types of applications, and we compare the results with a Chromium-based approach.

  19. Efficient temporal and interlayer parameter prediction for weighted prediction in scalable high efficiency video coding

    NASA Astrophysics Data System (ADS)

    Tsang, Sik-Ho; Chan, Yui-Lam; Siu, Wan-Chi

    2017-01-01

    Weighted prediction (WP) is an efficient video coding tool that was introduced since the establishment of the H.264/AVC video coding standard, for compensating the temporal illumination change in motion estimation and compensation. WP parameters, including a multiplicative weight and an additive offset for each reference frame, are required to be estimated and transmitted to the decoder by slice header. These parameters cause extra bits in the coded video bitstream. High efficiency video coding (HEVC) provides WP parameter prediction to reduce the overhead. Therefore, WP parameter prediction is crucial to research works or applications, which are related to WP. Prior art has been suggested to further improve the WP parameter prediction by implicit prediction of image characteristics and derivation of parameters. By exploiting both temporal and interlayer redundancies, we propose three WP parameter prediction algorithms, enhanced implicit WP parameter, enhanced direct WP parameter derivation, and interlayer WP parameter, to further improve the coding efficiency of HEVC. Results show that our proposed algorithms can achieve up to 5.83% and 5.23% bitrate reduction compared to the conventional scalable HEVC in the base layer for SNR scalability and 2× spatial scalability, respectively.

  20. Computational design and analysis of high strength austenitic TRIP steels for blast protection applications

    NASA Astrophysics Data System (ADS)

    Sadhukhan, Padmanava

    known to exhibit high uniform elongation, tensile strength under static and dynamic loads, and high fracture toughness due to mechanically induced martensitic transformation. The phenomenon of Transformation-Induced Plasticity (TRIP) arising from the FCC → BCC martensitic transformation has been used to create theoretical parametric models of matrix stability, flow stabilization and fragment resistance under tension and shear loads which were then applied to obtain significant improvements in uniform ductility for both stress states. These stability models have then been calibrated through experimental data from static and dynamic/adiabatic tensile tests and characteristic MSsigma temperature measurements from an earlier TRIP prototype to support the new alloy designs. BA120 and SA120 alloys are designed to undergo stress-assisted martensite transformation at a pre-determined critical temperature (MSsigma) thereby optimizing transformation plasticity to achieve the desired performance improvements. The new prototype alloy BA120 has demonstrated improved mechanical properties with a high strength of 124 ksi (845 MPa) and ˜ 150 ksi (1040 MPa) under static and dynamic tensile loading at room temperature. The measured uniform ductility for BA120 under quasi-static 6 tensile loading is 21% at room temperature with high strain hardening leading to UTS of 246 ksi (1696 MPa). The UTS under dynamic loading is ˜ 195 ksi (1344 MPa). The uniform ductility is consistent (21% - 24%) over a wide range of temperature (25°C -- 65°C). Mechanical testing demonstrates the required MSsigma temperature, and 3-D LEAP microanalysis confirms the predicted matrix composition as well as the particle size and distribution of strengthening precipitates. FSI simulation experiments conducted on BA120 to analyze the material behavior under actual blast loading have shown promising results in terms of strains exceeding 40%. A prescribed simple heat treatment process comprising of solutionizing

  1. Scalable fabrication of high-quality, ultra-thin single crystal diamond membrane windows

    NASA Astrophysics Data System (ADS)

    Piracha, Afaq Habib; Ganesan, Kumaravelu; Lau, Desmond W. M.; Stacey, Alastair; McGuinness, Liam P.; Tomljenovic-Hanic, Snjezana; Prawer, Steven

    2016-03-01

    High quality, ultra-thin single crystal diamond (SCD) membranes that have a thickness in the sub-micron range are of extreme importance as a materials platform for photonics, quantum sensing, nano/micro electro-mechanical systems (N/MEMS) and other diverse applications. However, the scalable fabrication of such thin SCD membranes is a challenging process. In this paper, we demonstrate a new method which enables high quality, large size (~4 × 4 mm) and low surface roughness, low strain, ultra-thin SCD membranes which can be fabricated without deformations such as breakage, bowing or bending. These membranes are easy to handle making them particularly suitable for fabrication of optical and mechanical devices. We demonstrate arrays of single crystal diamond membrane windows (SCDMW), each up to 1 × 1 mm in dimension and as thin as ~300 nm, supported by a diamond frame as thick as ~150 μm. The fabrication method is robust, reproducible, scalable and cost effective. Microwave plasma chemical vapour deposition is used for in situ creation of single nitrogen-vacancy (NV) centers into the thin SCDMW. We have also developed SCD drum head mechanical resonator composed of our fully clamped and freely suspended membranes.High quality, ultra-thin single crystal diamond (SCD) membranes that have a thickness in the sub-micron range are of extreme importance as a materials platform for photonics, quantum sensing, nano/micro electro-mechanical systems (N/MEMS) and other diverse applications. However, the scalable fabrication of such thin SCD membranes is a challenging process. In this paper, we demonstrate a new method which enables high quality, large size (~4 × 4 mm) and low surface roughness, low strain, ultra-thin SCD membranes which can be fabricated without deformations such as breakage, bowing or bending. These membranes are easy to handle making them particularly suitable for fabrication of optical and mechanical devices. We demonstrate arrays of single crystal diamond

  2. Lilith: A Java framework for the development of scalable tools for high performance distributed computing platforms

    SciTech Connect

    Evensky, D.A.; Gentile, A.C.; Armstrong, R.C.

    1998-03-19

    Increasingly, high performance computing constitutes the use of very large heterogeneous clusters of machines. The use and maintenance of such clusters are subject to complexities of communication between the machines in a time efficient and secure manner. Lilith is a general purpose tool that provides a highly scalable, secure, and easy distribution of user code across a heterogeneous computing platform. By handling the details of code distribution and communication, such a framework allows for the rapid development of tools for the use and management of large distributed systems. Lilith is written in Java, taking advantage of Java`s unique features of loading and distributing code dynamically, its platform independence, its thread support, and its provision of graphical components to facilitate easy to use resultant tools. The authors describe the use of Lilith in a tool developed for the maintenance of the large distributed cluster at their institution and present details of the Lilith architecture and user API for the general user development of scalable tools.

  3. The Open Connectome Project Data Cluster: Scalable Analysis and Vision for High-Throughput Neuroscience.

    PubMed

    Burns, Randal; Roncal, William Gray; Kleissas, Dean; Lillaney, Kunal; Manavalan, Priya; Perlman, Eric; Berger, Daniel R; Bock, Davi D; Chung, Kwanghun; Grosenick, Logan; Kasthuri, Narayanan; Weiler, Nicholas C; Deisseroth, Karl; Kazhdan, Michael; Lichtman, Jeff; Reid, R Clay; Smith, Stephen J; Szalay, Alexander S; Vogelstein, Joshua T; Vogelstein, R Jacob

    2013-01-01

    We describe a scalable database cluster for the spatial analysis and annotation of high-throughput brain imaging data, initially for 3-d electron microscopy image stacks, but for time-series and multi-channel data as well. The system was designed primarily for workloads that build connectomes- neural connectivity maps of the brain-using the parallel execution of computer vision algorithms on high-performance compute clusters. These services and open-science data sets are publicly available at openconnecto.me. The system design inherits much from NoSQL scale-out and data-intensive computing architectures. We distribute data to cluster nodes by partitioning a spatial index. We direct I/O to different systems-reads to parallel disk arrays and writes to solid-state storage-to avoid I/O interference and maximize throughput. All programming interfaces are RESTful Web services, which are simple and stateless, improving scalability and usability. We include a performance evaluation of the production system, highlighting the effec-tiveness of spatial data organization.

  4. The Open Connectome Project Data Cluster: Scalable Analysis and Vision for High-Throughput Neuroscience

    PubMed Central

    Burns, Randal; Roncal, William Gray; Kleissas, Dean; Lillaney, Kunal; Manavalan, Priya; Perlman, Eric; Berger, Daniel R.; Bock, Davi D.; Chung, Kwanghun; Grosenick, Logan; Kasthuri, Narayanan; Weiler, Nicholas C.; Deisseroth, Karl; Kazhdan, Michael; Lichtman, Jeff; Reid, R. Clay; Smith, Stephen J.; Szalay, Alexander S.; Vogelstein, Joshua T.; Vogelstein, R. Jacob

    2013-01-01

    We describe a scalable database cluster for the spatial analysis and annotation of high-throughput brain imaging data, initially for 3-d electron microscopy image stacks, but for time-series and multi-channel data as well. The system was designed primarily for workloads that build connectomes— neural connectivity maps of the brain—using the parallel execution of computer vision algorithms on high-performance compute clusters. These services and open-science data sets are publicly available at openconnecto.me. The system design inherits much from NoSQL scale-out and data-intensive computing architectures. We distribute data to cluster nodes by partitioning a spatial index. We direct I/O to different systems—reads to parallel disk arrays and writes to solid-state storage—to avoid I/O interference and maximize throughput. All programming interfaces are RESTful Web services, which are simple and stateless, improving scalability and usability. We include a performance evaluation of the production system, highlighting the effec-tiveness of spatial data organization. PMID:24401992

  5. Scalable Growth of High Mobility Dirac Semimetal Cd3As2 Microbelts.

    PubMed

    Chen, Zhi-Gang; Zhang, Cheng; Zou, Yichao; Zhang, Enze; Yang, Lei; Hong, Min; Xiu, Faxian; Zou, Jin

    2015-09-09

    Three-dimensional (3D) Dirac semimetals are 3D analogues of graphene, which display Dirac points with linear dispersion in k-space, stabilized by crystal symmetry. Cd3As2 has been predicted to be 3D Dirac semimetals and was subsequently demonstrated by angle-resolved photoemission spectroscopy. As unveiled by transport measurements, several exotic phases, such as Weyl semimetals, topological insulators, and topological superconductors, can be deduced by breaking time reversal or inversion symmetry. Here, we reported a facile and scalable chemical vapor deposition method to fabricate high-quality Dirac semimetal Cd3As2 microbelts; they have shown ultrahigh mobility up to 1.15 × 10(5) cm(2) V(-1) s(-1) and pronounced Shubnikov-de Haas oscillations. Such extraordinary features are attributed to the suppression of electron backscattering. This research opens a new avenue for the scalable fabrication of Cd3As2 materials toward exciting electronic applications of 3D Dirac semimetals.

  6. Construction of a Smart Medication Dispenser with High Degree of Scalability and Remote Manageability

    PubMed Central

    Pak, JuGeon; Park, KeeHyun

    2012-01-01

    We propose a smart medication dispenser having a high degree of scalability and remote manageability. We construct the dispenser to have extensible hardware architecture for achieving scalability, and we install an agent program in it for achieving remote manageability. The dispenser operates as follows: when the real-time clock reaches the predetermined medication time and the user presses the dispense button at that time, the predetermined medication is dispensed from the medication dispensing tray (MDT). In the proposed dispenser, the medication for each patient is stored in an MDT. One smart medication dispenser contains mainly one MDT; however, the dispenser can be extended to include more MDTs in order to support multiple users using one dispenser. For remote management, the proposed dispenser transmits the medication status and the system configurations to the monitoring server. In the case of a specific event such as a shortage of medication, memory overload, software error, or non-adherence, the event is transmitted immediately. All these operations are performed automatically without the intervention of patients, through the agent program installed in the dispenser. Results of implementation and verification show that the proposed dispenser operates normally and performs the management operations from the medication monitoring server suitably. PMID:22899886

  7. Thermally efficient and highly scalable In2Se3 nanowire phase change memory

    NASA Astrophysics Data System (ADS)

    Jin, Bo; Kang, Daegun; Kim, Jungsik; Meyyappan, M.; Lee, Jeong-Soo

    2013-04-01

    The electrical characteristics of nonvolatile In2Se3 nanowire phase change memory are reported. Size-dependent memory switching behavior was observed in nanowires of varying diameters and the reduction in set/reset threshold voltage was as low as 3.45 V/6.25 V for a 60 nm nanowire, which is promising for highly scalable nanowire memory applications. Also, size-dependent thermal resistance of In2Se3 nanowire memory cells was estimated with values as high as 5.86×1013 and 1.04×106 K/W for a 60 nm nanowire memory cell in amorphous and crystalline phases, respectively. Such high thermal resistances are beneficial for improvement of thermal efficiency and thus reduction in programming power consumption based on Fourier's law. The evaluation of thermal resistance provides an avenue to develop thermally efficient memory cell architecture.

  8. A scalable silicon photonic chip-scale optical switch for high performance computing systems.

    PubMed

    Yu, Runxiang; Cheung, Stanley; Li, Yuliang; Okamoto, Katsunari; Proietti, Roberto; Yin, Yawei; Yoo, S J B

    2013-12-30

    This paper discusses the architecture and provides performance studies of a silicon photonic chip-scale optical switch for scalable interconnect network in high performance computing systems. The proposed switch exploits optical wavelength parallelism and wavelength routing characteristics of an Arrayed Waveguide Grating Router (AWGR) to allow contention resolution in the wavelength domain. Simulation results from a cycle-accurate network simulator indicate that, even with only two transmitter/receiver pairs per node, the switch exhibits lower end-to-end latency and higher throughput at high (>90%) input loads compared with electronic switches. On the device integration level, we propose to integrate all the components (ring modulators, photodetectors and AWGR) on a CMOS-compatible silicon photonic platform to ensure a compact, energy efficient and cost-effective device. We successfully demonstrate proof-of-concept routing functions on an 8 × 8 prototype fabricated using foundry services provided by OpSIS-IME.

  9. Frontier: High Performance Database Access Using Standard Web Components in a Scalable Multi-Tier Architecture

    SciTech Connect

    Kosyakov, S.; Kowalkowski, J.; Litvintsev, D.; Lueking, L.; Paterno, M.; White, S.P.; Autio, Lauri; Blumenfeld, B.; Maksimovic, P.; Mathis, M.; /Johns Hopkins U.

    2004-09-01

    A high performance system has been assembled using standard web components to deliver database information to a large number of broadly distributed clients. The CDF Experiment at Fermilab is establishing processing centers around the world imposing a high demand on their database repository. For delivering read-only data, such as calibrations, trigger information, and run conditions data, we have abstracted the interface that clients use to retrieve data objects. A middle tier is deployed that translates client requests into database specific queries and returns the data to the client as XML datagrams. The database connection management, request translation, and data encoding are accomplished in servlets running under Tomcat. Squid Proxy caching layers are deployed near the Tomcat servers, as well as close to the clients, to significantly reduce the load on the database and provide a scalable deployment model. Details the system's construction and use are presented, including its architecture, design, interfaces, administration, performance measurements, and deployment plan.

  10. Scalable High Performance Message Passing over InfiniBand for Open MPI

    SciTech Connect

    Friedley, A; Hoefler, T; Leininger, M L; Lumsdaine, A

    2007-10-24

    InfiniBand (IB) is a popular network technology for modern high-performance computing systems. MPI implementations traditionally support IB using a reliable, connection-oriented (RC) transport. However, per-process resource usage that grows linearly with the number of processes, makes this approach prohibitive for large-scale systems. IB provides an alternative in the form of a connectionless unreliable datagram transport (UD), which allows for near-constant resource usage and initialization overhead as the process count increases. This paper describes a UD-based implementation for IB in Open MPI as a scalable alternative to existing RC-based schemes. We use the software reliability capabilities of Open MPI to provide the guaranteed delivery semantics required by MPI. Results show that UD not only requires fewer resources at scale, but also allows for shorter MPI startup times. A connectionless model also improves performance for applications that tend to send small messages to many different processes.

  11. Highly Efficient and Scalable Separation of Semiconducting Carbon Nanotubes via Weak Field Centrifugation

    PubMed Central

    Reis, Wieland G.; Weitz, R. Thomas; Kettner, Michel; Kraus, Alexander; Schwab, Matthias Georg; Tomović, Željko; Krupke, Ralph; Mikhael, Jules

    2016-01-01

    The identification of scalable processes that transfer random mixtures of single-walled carbon nanotubes (SWCNTs) into fractions featuring a high content of semiconducting species is crucial for future application of SWCNTs in high-performance electronics. Herein we demonstrate a highly efficient and simple separation method that relies on selective interactions between tailor-made amphiphilic polymers and semiconducting SWCNTs in the presence of low viscosity separation media. High purity individualized semiconducting SWCNTs or even self-organized semiconducting sheets are separated from an as-produced SWCNT dispersion via a single weak field centrifugation run. Absorption and Raman spectroscopy are applied to verify the high purity of the obtained SWCNTs. Furthermore SWCNT - network field-effect transistors were fabricated, which exhibit high ON/OFF ratios (105) and field-effect mobilities (17 cm2/Vs). In addition to demonstrating the feasibility of high purity separation by a novel low complexity process, our method can be readily transferred to large scale production. PMID:27188435

  12. Highly Efficient and Scalable Separation of Semiconducting Carbon Nanotubes via Weak Field Centrifugation

    NASA Astrophysics Data System (ADS)

    Reis, Wieland G.; Weitz, R. Thomas; Kettner, Michel; Kraus, Alexander; Schwab, Matthias Georg; Tomović, Željko; Krupke, Ralph; Mikhael, Jules

    2016-05-01

    The identification of scalable processes that transfer random mixtures of single-walled carbon nanotubes (SWCNTs) into fractions featuring a high content of semiconducting species is crucial for future application of SWCNTs in high-performance electronics. Herein we demonstrate a highly efficient and simple separation method that relies on selective interactions between tailor-made amphiphilic polymers and semiconducting SWCNTs in the presence of low viscosity separation media. High purity individualized semiconducting SWCNTs or even self-organized semiconducting sheets are separated from an as-produced SWCNT dispersion via a single weak field centrifugation run. Absorption and Raman spectroscopy are applied to verify the high purity of the obtained SWCNTs. Furthermore SWCNT - network field-effect transistors were fabricated, which exhibit high ON/OFF ratios (105) and field-effect mobilities (17 cm2/Vs). In addition to demonstrating the feasibility of high purity separation by a novel low complexity process, our method can be readily transferred to large scale production.

  13. Evaluation of in-network adaptation of scalable high efficiency video coding (SHVC) in mobile environments

    NASA Astrophysics Data System (ADS)

    Nightingale, James; Wang, Qi; Grecos, Christos; Goma, Sergio

    2014-02-01

    High Efficiency Video Coding (HEVC), the latest video compression standard (also known as H.265), can deliver video streams of comparable quality to the current H.264 Advanced Video Coding (H.264/AVC) standard with a 50% reduction in bandwidth. Research into SHVC, the scalable extension to the HEVC standard, is still in its infancy. One important area for investigation is whether, given the greater compression ratio of HEVC (and SHVC), the loss of packets containing video content will have a greater impact on the quality of delivered video than is the case with H.264/AVC or its scalable extension H.264/SVC. In this work we empirically evaluate the layer-based, in-network adaptation of video streams encoded using SHVC in situations where dynamically changing bandwidths and datagram loss ratios require the real-time adaptation of video streams. Through the use of extensive experimentation, we establish a comprehensive set of benchmarks for SHVC-based highdefinition video streaming in loss prone network environments such as those commonly found in mobile networks. Among other results, we highlight that packet losses of only 1% can lead to a substantial reduction in PSNR of over 3dB and error propagation in over 130 pictures following the one in which the loss occurred. This work would be one of the earliest studies in this cutting-edge area that reports benchmark evaluation results for the effects of datagram loss on SHVC picture quality and offers empirical and analytical insights into SHVC adaptation to lossy, mobile networking conditions.

  14. Isolation of urinary exosomes for RNA biomarker discovery using a simple, fast, and highly scalable method.

    PubMed

    Alvarez, M Lucrecia

    2014-01-01

    Urinary exosomes are nanovesicles (40-100 nm) of endocytic origin that are secreted into the urine when a multivesicular body fuses with the membrane of cells from all nephron segments. Interest in urinary exosomes intensified after the discovery that they contain not only protein and mRNA but also microRNA (miRNA) markers of renal dysfunction and structural injury. Currently, the most widely used protocol for the isolation of urinary exosomes is based on ultracentrifugation, a method that is time consuming, requires expensive equipment, and has low scalability, which limits its applicability in the clinical practice. In this chapter, a simple, fast, and highly scalable step-by-step method for isolation of urinary exosomes is described. This method starts with a 10-min centrifugation of 10 ml urine, then the supernatant is saved (SN1), and the pellet is treated with dithiothreitol and heat to release and recover those exosomes entrapped by polymeric Tamm-Horsfall protein. The treated pellet is then resuspended and centrifuged, and the supernatant obtained (SN2) is combined with the first supernatant, SN1. Next, 3.3 ml of ExoQuick-TC, a commercial exosome precipitation reagent, is added to the total supernatant (SN1 + SN2), mixed well, and saved for at least 12 h at 4 °C. Finally, a pellet of exosomes is obtained after a 30-min centrifugation of the supernatant/ExoQuick-TC mix. We previously compared this method with five others used to isolate urinary exosomes and found that this is the simplest, fastest, and most effective alternative to ultracentrifugation-based protocols if the goal of the study is RNA profiling. A method for isolation and quantification of miRNAs and mRNAs from urinary exosomes is also described here. In addition, we provide a step-by-step description of exosomal miRNA profiling using universal reverse transcription and SYBR qPCR.

  15. Investigation on scalable high-power lasers with enhanced 'eye-safety' for future weapon systems

    NASA Astrophysics Data System (ADS)

    Bigotta, S.; Diener, K.; Eichhorn, M.; Galecki, L.; Geiss, L.; Ibach, T.; Scharf, H.; von Salisch, M.; Schöner, J.; Vincent, G.

    2016-10-01

    The possible use of lasers as weapons becomes more and more interesting for military forces. Besides the generation of high laser power and good beam quality, also safety considerations, e. g. concerning eye hazards, are of importance. The MELIAS (medium energy laser in the "eye-safe" spectral domain) project of ISL addresses these issues, and ISL has developed the most powerful solid-state laser in the "eye-safe" wavelength region up to now. "Eye safety" in this context means that light at a wavelength of > 1.4 μm does not penetrate the eye and thus will not be focused onto the retina. The basic principle of this technology is that a laser source needs to be scalable in power to far beyond 100 kW without a significant deterioration in beam quality. ISL has studied a very promising laser technology: the erbium heat-capacity laser. This type of laser is characterised by a compact design, a simple and robust technology and a scaling law which, in principle, allows the generation of laser power far beyond megawatts at small volumes. Previous investigations demonstrated the scalability of the SSHCL and up to 4.65 kW and 440 J in less than 800 ms have been obtained. Opticalto- optical efficiencies of over 41% and slope efficiencies of over 51% are obtained. The residual thermal gradients, due to non perfect pumping homogeneity, negatively affect the performance in terms of laser pulse energy, duration and beam quality. In the course of the next two years, ISL will be designing a 25 to 30 kW erbium heat-capacity laser.

  16. The Effect of Current-Limiting Reactors on the Tripping of Short Circuits in High-Voltage Electrical Equipment

    SciTech Connect

    Volkov, M. S.; Gusev, Yu. P. Monakov, Yu. V.; Cho, Gvan Chun

    2016-01-15

    The insertion of current-limiting reactors into electrical equipment operating at a voltage of 110 and 220 kV produces a change in the parameters of the transient recovery voltages at the contacts of the circuit breakers for disconnecting short circuits, which could be the reason for the increase in the duration of the short circuit, damage to the electrical equipment and losses in the power system. The results of mathematical modeling of the transients, caused by tripping of the short circuit in a reactive electric power transmission line are presented, and data are given on the negative effect of a current-limiting resistor on the rate of increase and peak value of the transient recovery voltages. Methods of ensuring the standard requirements imposed on the parameters of the transient recovery voltages when using current-limiting reactors in the high-voltage electrical equipment of power plants and substations are proposed and analyzed.

  17. Scalable Sub-micron Patterning of Organic Materials Toward High Density Soft Electronics

    NASA Astrophysics Data System (ADS)

    Kim, Jaekyun; Kim, Myung-Gil; Kim, Jaehyun; Jo, Sangho; Kang, Jingu; Jo, Jeong-Wan; Lee, Woobin; Hwang, Chahwan; Moon, Juhyuk; Yang, Lin; Kim, Yun-Hi; Noh, Yong-Young; Yun Jaung, Jae; Kim, Yong-Hoon; Kyu Park, Sung

    2015-09-01

    The success of silicon based high density integrated circuits ignited explosive expansion of microelectronics. Although the inorganic semiconductors have shown superior carrier mobilities for conventional high speed switching devices, the emergence of unconventional applications, such as flexible electronics, highly sensitive photosensors, large area sensor array, and tailored optoelectronics, brought intensive research on next generation electronic materials. The rationally designed multifunctional soft electronic materials, organic and carbon-based semiconductors, are demonstrated with low-cost solution process, exceptional mechanical stability, and on-demand optoelectronic properties. Unfortunately, the industrial implementation of the soft electronic materials has been hindered due to lack of scalable fine-patterning methods. In this report, we demonstrated facile general route for high throughput sub-micron patterning of soft materials, using spatially selective deep-ultraviolet irradiation. For organic and carbon-based materials, the highly energetic photons (e.g. deep-ultraviolet rays) enable direct photo-conversion from conducting/semiconducting to insulating state through molecular dissociation and disordering with spatial resolution down to a sub-μm-scale. The successful demonstration of organic semiconductor circuitry promise our result proliferate industrial adoption of soft materials for next generation electronics.

  18. Scalable sub-micron patterning of organic materials toward high density soft electronics

    SciTech Connect

    Kim, Jaekyun; Kim, Myung -Gil; Kim, Jaehyun; Jo, Sangho; Kang, Jingu; Jo, Jeong -Wan; Lee, Woobin; Hwang, Chahwan; Moon, Juhyuk; Yang, Lin; Kim, Yun -Hi; Noh, Yong -Young; Yun Jaung, Jae; Kim, Yong -Hoon; Kyu Park, Sung

    2015-09-28

    The success of silicon based high density integrated circuits ignited explosive expansion of microelectronics. Although the inorganic semiconductors have shown superior carrier mobilities for conventional high speed switching devices, the emergence of unconventional applications, such as flexible electronics, highly sensitive photosensors, large area sensor array, and tailored optoelectronics, brought intensive research on next generation electronic materials. The rationally designed multifunctional soft electronic materials, organic and carbon-based semiconductors, are demonstrated with low-cost solution process, exceptional mechanical stability, and on-demand optoelectronic properties. Unfortunately, the industrial implementation of the soft electronic materials has been hindered due to lack of scalable fine-patterning methods. In this report, we demonstrated facile general route for high throughput sub-micron patterning of soft materials, using spatially selective deep-ultraviolet irradiation. For organic and carbon-based materials, the highly energetic photons (e.g. deep-ultraviolet rays) enable direct photo-conversion from conducting/semiconducting to insulating state through molecular dissociation and disordering with spatial resolution down to a sub-μm-scale. As a result, the successful demonstration of organic semiconductor circuitry promise our result proliferate industrial adoption of soft materials for next generation electronics.

  19. Scalable sub-micron patterning of organic materials toward high density soft electronics

    DOE PAGES

    Kim, Jaekyun; Kim, Myung -Gil; Kim, Jaehyun; ...

    2015-09-28

    The success of silicon based high density integrated circuits ignited explosive expansion of microelectronics. Although the inorganic semiconductors have shown superior carrier mobilities for conventional high speed switching devices, the emergence of unconventional applications, such as flexible electronics, highly sensitive photosensors, large area sensor array, and tailored optoelectronics, brought intensive research on next generation electronic materials. The rationally designed multifunctional soft electronic materials, organic and carbon-based semiconductors, are demonstrated with low-cost solution process, exceptional mechanical stability, and on-demand optoelectronic properties. Unfortunately, the industrial implementation of the soft electronic materials has been hindered due to lack of scalable fine-patterning methods. Inmore » this report, we demonstrated facile general route for high throughput sub-micron patterning of soft materials, using spatially selective deep-ultraviolet irradiation. For organic and carbon-based materials, the highly energetic photons (e.g. deep-ultraviolet rays) enable direct photo-conversion from conducting/semiconducting to insulating state through molecular dissociation and disordering with spatial resolution down to a sub-μm-scale. As a result, the successful demonstration of organic semiconductor circuitry promise our result proliferate industrial adoption of soft materials for next generation electronics.« less

  20. Scalable Sub-micron Patterning of Organic Materials Toward High Density Soft Electronics

    PubMed Central

    Kim, Jaekyun; Kim, Myung-Gil; Kim, Jaehyun; Jo, Sangho; Kang, Jingu; Jo, Jeong-Wan; Lee, Woobin; Hwang, Chahwan; Moon, Juhyuk; Yang, Lin; Kim, Yun-Hi; Noh, Yong-Young; Yun Jaung, Jae; Kim, Yong-Hoon; Kyu Park, Sung

    2015-01-01

    The success of silicon based high density integrated circuits ignited explosive expansion of microelectronics. Although the inorganic semiconductors have shown superior carrier mobilities for conventional high speed switching devices, the emergence of unconventional applications, such as flexible electronics, highly sensitive photosensors, large area sensor array, and tailored optoelectronics, brought intensive research on next generation electronic materials. The rationally designed multifunctional soft electronic materials, organic and carbon-based semiconductors, are demonstrated with low-cost solution process, exceptional mechanical stability, and on-demand optoelectronic properties. Unfortunately, the industrial implementation of the soft electronic materials has been hindered due to lack of scalable fine-patterning methods. In this report, we demonstrated facile general route for high throughput sub-micron patterning of soft materials, using spatially selective deep-ultraviolet irradiation. For organic and carbon-based materials, the highly energetic photons (e.g. deep-ultraviolet rays) enable direct photo-conversion from conducting/semiconducting to insulating state through molecular dissociation and disordering with spatial resolution down to a sub-μm-scale. The successful demonstration of organic semiconductor circuitry promise our result proliferate industrial adoption of soft materials for next generation electronics. PMID:26411932

  1. Scalable Sub-micron Patterning of Organic Materials Toward High Density Soft Electronics.

    PubMed

    Kim, Jaekyun; Kim, Myung-Gil; Kim, Jaehyun; Jo, Sangho; Kang, Jingu; Jo, Jeong-Wan; Lee, Woobin; Hwang, Chahwan; Moon, Juhyuk; Yang, Lin; Kim, Yun-Hi; Noh, Yong-Young; Jaung, Jae Yun; Kim, Yong-Hoon; Park, Sung Kyu

    2015-09-28

    The success of silicon based high density integrated circuits ignited explosive expansion of microelectronics. Although the inorganic semiconductors have shown superior carrier mobilities for conventional high speed switching devices, the emergence of unconventional applications, such as flexible electronics, highly sensitive photosensors, large area sensor array, and tailored optoelectronics, brought intensive research on next generation electronic materials. The rationally designed multifunctional soft electronic materials, organic and carbon-based semiconductors, are demonstrated with low-cost solution process, exceptional mechanical stability, and on-demand optoelectronic properties. Unfortunately, the industrial implementation of the soft electronic materials has been hindered due to lack of scalable fine-patterning methods. In this report, we demonstrated facile general route for high throughput sub-micron patterning of soft materials, using spatially selective deep-ultraviolet irradiation. For organic and carbon-based materials, the highly energetic photons (e.g. deep-ultraviolet rays) enable direct photo-conversion from conducting/semiconducting to insulating state through molecular dissociation and disordering with spatial resolution down to a sub-μm-scale. The successful demonstration of organic semiconductor circuitry promise our result proliferate industrial adoption of soft materials for next generation electronics.

  2. Scalable fabrication of micron-scale graphene nanomeshes for high-performance supercapacitor applications

    DOE PAGES

    Kim, Hyun-Kyung; Bak, Seong-Min; Lee, Suk Woo; ...

    2016-01-27

    Graphene nanomeshes (GNMs) with nanoscale periodic or quasi-periodic nanoholes have attracted considerable interest because of unique features such as their open energy band gap, enlarged specific surface area, and high optical transmittance. These features are useful for applications in semiconducting devices, photocatalysis, sensors, and energy-related systems. We report on the facile and scalable preparation of multifunctional micron-scale GNMs with high-density of nanoperforations by catalytic carbon gasification. The catalytic carbon gasification process induces selective decomposition on the graphene adjacent to the metal catalyst, thus forming nanoperforations. Furthermore, the pore size, pore density distribution, and neck size of the GNMs can bemore » controlled by adjusting the size and fraction of the metal oxide on graphene. The fabricated GNM electrodes exhibit superior electrochemical properties for supercapacitor (ultracapacitor) applications, including exceptionally high capacitance (253 F g-1 at 1 A g-1) and high rate capability (212 F g-1 at 100 A g-1) with excellent cycle stability (91% of the initial capacitance after 50 000 charge/discharge cycles). Moreover, the edge-enriched structure of GNMs plays an important role in achieving edge-selected and high-level nitrogen doping.« less

  3. Scalable fabrication of micron-scale graphene nanomeshes for high-performance supercapacitor applications

    SciTech Connect

    Kim, Hyun-Kyung; Bak, Seong-Min; Lee, Suk Woo; Kim, Myeong-Seong; Park, Byeongho; Lee, Su Chan; Choi, Yeon Jun; Jun, Seong Chan; Han, Joong Tark; Nam, Kyung-Wan; Chung, Kyung Yoon; Wang, Jian; Zhou, Jigang; Yang, Xiao-Qing; Roh, Kwang Chul; Kim, Kwang-Bum

    2016-01-27

    Graphene nanomeshes (GNMs) with nanoscale periodic or quasi-periodic nanoholes have attracted considerable interest because of unique features such as their open energy band gap, enlarged specific surface area, and high optical transmittance. These features are useful for applications in semiconducting devices, photocatalysis, sensors, and energy-related systems. We report on the facile and scalable preparation of multifunctional micron-scale GNMs with high-density of nanoperforations by catalytic carbon gasification. The catalytic carbon gasification process induces selective decomposition on the graphene adjacent to the metal catalyst, thus forming nanoperforations. Furthermore, the pore size, pore density distribution, and neck size of the GNMs can be controlled by adjusting the size and fraction of the metal oxide on graphene. The fabricated GNM electrodes exhibit superior electrochemical properties for supercapacitor (ultracapacitor) applications, including exceptionally high capacitance (253 F g-1 at 1 A g-1) and high rate capability (212 F g-1 at 100 A g-1) with excellent cycle stability (91% of the initial capacitance after 50 000 charge/discharge cycles). Moreover, the edge-enriched structure of GNMs plays an important role in achieving edge-selected and high-level nitrogen doping.

  4. Scalable, high-performance 3D imaging software platform: system architecture and application to virtual colonoscopy.

    PubMed

    Yoshida, Hiroyuki; Wu, Yin; Cai, Wenli; Brett, Bevin

    2012-01-01

    One of the key challenges in three-dimensional (3D) medical imaging is to enable the fast turn-around time, which is often required for interactive or real-time response. This inevitably requires not only high computational power but also high memory bandwidth due to the massive amount of data that need to be processed. In this work, we have developed a software platform that is designed to support high-performance 3D medical image processing for a wide range of applications using increasingly available and affordable commodity computing systems: multi-core, clusters, and cloud computing systems. To achieve scalable, high-performance computing, our platform (1) employs size-adaptive, distributable block volumes as a core data structure for efficient parallelization of a wide range of 3D image processing algorithms; (2) supports task scheduling for efficient load distribution and balancing; and (3) consists of a layered parallel software libraries that allow a wide range of medical applications to share the same functionalities. We evaluated the performance of our platform by applying it to an electronic cleansing system in virtual colonoscopy, with initial experimental results showing a 10 times performance improvement on an 8-core workstation over the original sequential implementation of the system.

  5. Scalable Functionalized Graphene Nano-platelets as Tunable Cathodes for High-performance Lithium Rechargeable Batteries

    PubMed Central

    Kim, Haegyeom; Lim, Hee-Dae; Kim, Sung-Wook; Hong, Jihyun; Seo, Dong-Hwa; Kim, Dae-chul; Jeon, Seokwoo; Park, Sungjin; Kang, Kisuk

    2013-01-01

    High-performance and cost-effective rechargeable batteries are key to the success of electric vehicles and large-scale energy storage systems. Extensive research has focused on the development of (i) new high-energy electrodes that can store more lithium or (ii) high-power nano-structured electrodes hybridized with carbonaceous materials. However, the current status of lithium batteries based on redox reactions of heavy transition metals still remains far below the demands required for the proposed applications. Herein, we present a novel approach using tunable functional groups on graphene nano-platelets as redox centers. The electrode can deliver high capacity of ~250 mAh g−1, power of ~20 kW kg−1 in an acceptable cathode voltage range, and provide excellent cyclability up to thousands of repeated charge/discharge cycles. The simple, mass-scalable synthetic route for the functionalized graphene nano-platelets proposed in this work suggests that the graphene cathode can be a promising new class of electrode. PMID:23514953

  6. XGet: a highly scalable and efficient file transfer tool for clusters

    SciTech Connect

    Greenberg, Hugh; Ionkov, Latchesar; Minnich, Ronald

    2008-01-01

    As clusters rapidly grow in size, transferring files between nodes can no longer be solved by the traditional transfer utilities due to their inherent lack of scalability. In this paper, we describe a new file transfer utility called XGet, which was designed to address the scalability problem of standard tools. We compared XGet against four transfer tools: Bittorrent, Rsync, TFTP, and Udpcast and our results show that XGet's performance is superior to the these utilities in many cases.

  7. Scalable parallel programming for high performance seismic simulation on petascale heterogeneous supercomputers

    NASA Astrophysics Data System (ADS)

    Zhou, Jun

    The 1994 Northridge earthquake in Los Angeles, California, killed 57 people, injured over 8,700 and caused an estimated $20 billion in damage. Petascale simulations are needed in California and elsewhere to provide society with a better understanding of the rupture and wave dynamics of the largest earthquakes at shaking frequencies required to engineer safe structures. As the heterogeneous supercomputing infrastructures are becoming more common, numerical developments in earthquake system research are particularly challenged by the dependence on the accelerator elements to enable "the Big One" simulations with higher frequency and finer resolution. Reducing time to solution and power consumption are two primary focus area today for the enabling technology of fault rupture dynamics and seismic wave propagation in realistic 3D models of the crust's heterogeneous structure. This dissertation presents scalable parallel programming techniques for high performance seismic simulation running on petascale heterogeneous supercomputers. A real world earthquake simulation code, AWP-ODC, one of the most advanced earthquake codes to date, was chosen as the base code in this research, and the testbed is based on Titan at Oak Ridge National Laboraratory, the world's largest hetergeneous supercomputer. The research work is primarily related to architecture study, computation performance tuning and software system scalability. An earthquake simulation workflow has also been developed to support the efficient production sets of simulations. The highlights of the technical development are an aggressive performance optimization focusing on data locality and a notable data communication model that hides the data communication latency. This development results in the optimal computation efficiency and throughput for the 13-point stencil code on heterogeneous systems, which can be extended to general high-order stencil codes. Started from scratch, the hybrid CPU/GPU version of AWP

  8. Frequency-sensitive competitive learning for scalable balanced clustering on high-dimensional hyperspheres.

    PubMed

    Banerjee, Arindam; Ghosh, Joydeep

    2004-05-01

    Competitive learning mechanisms for clustering, in general, suffer from poor performance for very high-dimensional (>1000) data because of "curse of dimensionality" effects. In applications such as document clustering, it is customary to normalize the high-dimensional input vectors to unit length, and it is sometimes also desirable to obtain balanced clusters, i.e., clusters of comparable sizes. The spherical kmeans (spkmeans) algorithm, which normalizes the cluster centers as well as the inputs, has been successfully used to cluster normalized text documents in 2000+ dimensional space. Unfortunately, like regular kmeans and its soft expectation-maximization-based version, spkmeans tends to generate extremely imbalanced clusters in high-dimensional spaces when the desired number of clusters is large (tens or more). This paper first shows that the spkmeans algorithm can be derived from a certain maximum likelihood formulation using a mixture of von Mises-Fisher distributions as the generative model, and in fact, it can be considered as a batch-mode version of (normalized) competitive learning. The proposed generative model is then adapted in a principled way to yield three frequency-sensitive competitive learning variants that are applicable to static data and produced high-quality and well-balanced clusters for high-dimensional data. Like kmeans, each iteration is linear in the number of data points and in the number of clusters for all the three algorithms. A frequency-sensitive algorithm to cluster streaming data is also proposed. Experimental results on clustering of high-dimensional text data sets are provided to show the effectiveness and applicability of the proposed techniques. Index Terms-Balanced clustering, expectation maximization (EM), frequency-sensitive competitive learning (FSCL), high-dimensional clustering, kmeans, normalized data, scalable clustering, streaming data, text clustering.

  9. High-performance graphene-based supercapacitors made by a scalable blade-coating approach

    NASA Astrophysics Data System (ADS)

    Wang, Bin; Liu, Jinzhang; Mirri, Francesca; Pasquali, Matteo; Motta, Nunzio; Holmes, John W.

    2016-04-01

    Graphene oxide (GO) sheets can form liquid crystals (LCs) in their aqueous dispersions that are more viscous with a stronger LC feature. In this work we combine the viscous LC-GO solution with the blade-coating technique to make GO films, for constructing graphene-based supercapacitors in a scalable way. Reduced GO (rGO) films are prepared by wet chemical methods, using either hydrazine (HZ) or hydroiodic acid (HI). Solid-state supercapacitors with rGO films as electrodes and highly conductive carbon nanotube films as current collectors are fabricated and the capacitive properties of different rGO films are compared. It is found that the HZ-rGO film is superior to the HI-rGO film in achieving high capacitance, owing to the 3D structure of graphene sheets in the electrode. Compared to gelled electrolyte, the use of liquid electrolyte (H2SO4) can further increase the capacitance to 265 F per gram (corresponding to 52 mF per cm2) of the HZ-rGO film.

  10. Planning a Field Trip

    ERIC Educational Resources Information Center

    Forecast for Home Economics, 1975

    1975-01-01

    The showroom of a button manufacturer was the site of a successful field trip for a New York City home economics class. Suggestions for field trip preparation are included as well as directions for making button jewelry. (EA)

  11. Very High Resolution Mapping of Tree Cover Using Scalable Deep Learning Architectures

    NASA Astrophysics Data System (ADS)

    ganguly, sangram; basu, saikat; nemani, ramakrishna; mukhopadhyay, supratik; michaelis, andrew; votava, petr; saatchi, sassan

    2016-04-01

    Several studies to date have provided an extensive knowledge base for estimating forest aboveground biomass (AGB) and recent advances in space-based modeling of the 3-D canopy structure, combined with canopy reflectance measured by passive optical sensors and radar backscatter, are providing improved satellite-derived AGB density mapping for large scale carbon monitoring applications. A key limitation in forest AGB estimation from remote sensing, however, is the large uncertainty in forest cover estimates from the coarse-to-medium resolution satellite-derived land cover maps (present resolution is limited to 30-m of the USGS NLCD Program). As part of our NASA Carbon Monitoring System Phase II activities, we have demonstrated that uncertainties in forest cover estimates at the Landsat scale result in high uncertainties in AGB estimation, predominantly in heterogeneous forest and urban landscapes. We have successfully tested an approach using scalable deep learning architectures (Feature-enhanced Deep Belief Networks and Semantic Segmentation using Convolutional Neural Networks) and High-Performance Computing with NAIP air-borne imagery data for mapping tree cover at 1-m over California and Maryland. Our first high resolution satellite training label dataset from the NAIP data can be found here at http://csc.lsu.edu/~saikat/deepsat/ . In a comparison with high resolution LiDAR data available over selected regions in the two states, we found our results to be promising both in terms of accuracy as well as our ability to scale nationally. In this project, we propose to estimate very high resolution forest cover for the continental US at spatial resolution of 1-m in support of reducing uncertainties in the AGB estimation. The proposed work will substantially contribute to filling the gaps in ongoing carbon monitoring research and help quantifying the errors and uncertainties in related carbon products.

  12. ScalaTrace: Scalable Compression and Replay of Communication Traces for High Performance Computing

    SciTech Connect

    Noeth, M; Ratn, P; Mueller, F; Schulz, M; de Supinski, B R

    2008-05-16

    Characterizing the communication behavior of large-scale applications is a difficult and costly task due to code/system complexity and long execution times. While many tools to study this behavior have been developed, these approaches either aggregate information in a lossy way through high-level statistics or produce huge trace files that are hard to handle. We contribute an approach that provides orders of magnitude smaller, if not near-constant size, communication traces regardless of the number of nodes while preserving structural information. We introduce intra- and inter-node compression techniques of MPI events that are capable of extracting an application's communication structure. We further present a replay mechanism for the traces generated by our approach and discuss results of our implementation for BlueGene/L. Given this novel capability, we discuss its impact on communication tuning and beyond. To the best of our knowledge, such a concise representation of MPI traces in a scalable manner combined with deterministic MPI call replay are without any precedent.

  13. Scalable graphite/copper bishell composite for high-performance interconnects.

    PubMed

    Yeh, Chao-Hui; Medina, Henry; Lu, Chun-Chieh; Huang, Kun-Ping; Liu, Zheng; Suenaga, Kazu; Chiu, Po-Wen

    2014-01-28

    We present the fabrication and characterizations of novel electrical interconnect test lines made of a Cu/graphite bishell composite with the graphite cap layer grown by electron cyclotron resonance chemical vapor deposition. Through this technique, conformal multilayer graphene can be formed on the predeposited Cu interconnects under CMOS-friendly conditions. The low-temperature (400 °C) deposition also renders the process unlimitedly scalable. The graphite layer can boost the current-carrying capacity of the composite structure to 10(8) A/cm(2), more than an order of magnitude higher than that of bare metal lines, and reduces resistivity of fine test lines by ∼10%. Raman measurements reveal that physical breakdown occurs at ∼680-720 °C. Modeling the current vs voltage curves up to breakdown shows that the maximum current density of the composites is limited by self-heating of the graphite, suggesting the strong roles of phonon scattering at high fields and highlighting the significance of a metal counterpart for enhanced thermal dissipation.

  14. A highly scalable massively parallel fast marching method for the Eikonal equation

    NASA Astrophysics Data System (ADS)

    Yang, Jianming; Stern, Frederick

    2017-03-01

    The fast marching method is a widely used numerical method for solving the Eikonal equation arising from a variety of scientific and engineering fields. It is long deemed inherently sequential and an efficient parallel algorithm applicable to large-scale practical applications is not available in the literature. In this study, we present a highly scalable massively parallel implementation of the fast marching method using a domain decomposition approach. Central to this algorithm is a novel restarted narrow band approach that coordinates the frequency of communications and the amount of computations extra to a sequential run for achieving an unprecedented parallel performance. Within each restart, the narrow band fast marching method is executed; simple synchronous local exchanges and global reductions are adopted for communicating updated data in the overlapping regions between neighboring subdomains and getting the latest front status, respectively. The independence of front characteristics is exploited through special data structures and augmented status tags to extract the masked parallelism within the fast marching method. The efficiency, flexibility, and applicability of the parallel algorithm are demonstrated through several examples. These problems are extensively tested on six grids with up to 1 billion points using different numbers of processes ranging from 1 to 65536. Remarkable parallel speedups are achieved using tens of thousands of processes. Detailed pseudo-codes for both the sequential and parallel algorithms are provided to illustrate the simplicity of the parallel implementation and its similarity to the sequential narrow band fast marching algorithm.

  15. Technical Report: Toward a Scalable Algorithm to Compute High-Dimensional Integrals of Arbitrary Functions

    SciTech Connect

    Snyder, Abigail C.; Jiao, Yu

    2010-10-01

    Neutron experiments at the Spallation Neutron Source (SNS) at Oak Ridge National Laboratory (ORNL) frequently generate large amounts of data (on the order of 106-1012 data points). Hence, traditional data analysis tools run on a single CPU take too long to be practical and scientists are unable to efficiently analyze all data generated by experiments. Our goal is to develop a scalable algorithm to efficiently compute high-dimensional integrals of arbitrary functions. This algorithm can then be used to integrate the four-dimensional integrals that arise as part of modeling intensity from the experiments at the SNS. Here, three different one-dimensional numerical integration solvers from the GNU Scientific Library were modified and implemented to solve four-dimensional integrals. The results of these solvers on a final integrand provided by scientists at the SNS can be compared to the results of other methods, such as quasi-Monte Carlo methods, computing the same integral. A parallelized version of the most efficient method can allow scientists the opportunity to more effectively analyze all experimental data.

  16. High-Sensitivity Charge Detection with a Single-Lead Quantum Dot for Scalable Quantum Computation

    NASA Astrophysics Data System (ADS)

    House, M. G.; Bartlett, I.; Pakkiam, P.; Koch, M.; Peretz, E.; van der Heijden, J.; Kobayashi, T.; Rogge, S.; Simmons, M. Y.

    2016-10-01

    We report the development of a high-sensitivity semiconductor charge sensor based on a quantum dot coupled to a single lead designed to minimize the geometric requirements of a charge sensor for scalable quantum-computing architectures. The quantum dot is fabricated in Si:P using atomic precision lithography, and its charge transitions are measured with rf reflectometry. A second quantum dot with two leads placed 42 nm away serves as both a charge for the sensor to measure and as a conventional rf single-electron transistor (rf SET) with which to make a comparison of the charge-detection sensitivity. We demonstrate sensitivity equivalent to an integration time of 550 ns to detect a single charge with a signal-to-noise ratio of 1 compared with an integration time of 55 ns for the rf SET. This level of sensitivity is suitable for fast (<15 μ s ) single-spin readout in quantum-information applications, with a significantly reduced geometric footprint compared to the rf SET.

  17. Optical design of a scalable imaging system with compact configuration and high fidelity

    NASA Astrophysics Data System (ADS)

    Ji, Yiqun; Chen, Yuheng; Zhou, Jiankang; Chen, Xinhua

    2016-10-01

    Optical design of a novel optical imaging system is presented. It can overcome the scaling of the aberrations by dividing the imaging task between a single objective lens that achieves a partially corrected intermediate image on a spherical surface, and an array of micro-lens, each of which relays a small portion of the intermediate image to its respective sensor, correcting the residual aberrations. The system is aimed for obtaining large field-of-view without deteriorating its resolution, of which traditionally designed optical imaging systems have met great difficult. This progress not only breaks through the traditional restrictions, but also allows a wider application for optical imaging systems. Firstly, proper configuration, which satisfies both the requirement of compactness and high performance, is determined according to the working principle of the novel system and through the research of the design idea in this paper. Then, a design example is presented with the field-of-view 50°and its resolution 0.2mrad, which remains as the field-of-view scales. But the optimized scalable system is of close packed structure and its dimension is less than 300mm along the ray incidence.

  18. Integrating geoscience and Native American experiences through a multi-state geoscience field trip for high school students

    NASA Astrophysics Data System (ADS)

    Kelso, P. R.; Brown, L. M.; Spencer, M.; Sabatine, S.; Goetz, E. R.

    2012-12-01

    experiences led by Lake Superior State University professors, K-12 earth science teachers, local science experts (most with tribal affiliation), and local Native American leaders. Student selection is based on an application that includes academic background and performance, a personal essay, and teacher and counselor references. All of the students invited to be part of the GRANITE program participated in the summer field excursion. The GRANITE summer field trip was structured to address over 50% of Michigan's high school geology standards. Each student's geoscience knowledge and interest is assessed through questionnaires administered pre- and post the summer field experience. Also, student feedback is gathered during the GRANITE field trip and more than six months post field trip. Students recorded field observations and discussion in their field books which they used to produce powerpoint slides summarizing and reflecting upon what they did and learned each day. Students' post field excursion, content-oriented scores increased each of the three years of the program. In addition to geosciences content growth, all of the students responded affirmatively that GRANITE "increased my understanding of how geoscientists study the Earth "and "increased my knowledge of the importance of geoscience to our society."

  19. ScalaBLAST: A Scalable Implementation of BLAST for High Performance Data-Intensive Bioinformatics Analysis

    SciTech Connect

    Oehmen, Chris S.; Nieplocha, Jarek

    2006-08-01

    Genes in an organism’s DNA (genome) have embedded in them information about proteins, which are the molecules that do most of a cell’s work. A typical bacterial genome contains on the order of 5000 genes. Mammalian genomes can contain hundreds of thousands of genes. For each genome sequenced, the challenge is to identify protein components (proteome) being actively used for a given set of conditions. Fundamentally, sequence alignment is a sequence matching problem focused at unlocking protein information embedded in the genetic code, making it possible to assemble a “tree of life” by comparing new sequences against all sequences from known organisms. But the memory footprint of sequence data is growing more rapidly than per-node core memory. Despite years of research and development, high performance sequence alignment applications either do not scale well, cannot accommodate very large databases in core, or require special hardware. We have developed a high performance sequence alignment application, ScalaBLAST, which accommodates very large databases, and which scales linearly to hundreds of processors on both distributed memory and shared memory architectures, representing a substantial improvement over the current state-of-the-art in high performance sequence alignment with scaling and portability. ScalaBLAST, relies on a collection of innovative techniques -- distributing the target database over available memory, multi-level parallelism to exploit concurrency, parallel I/O, and latency hiding through data prefetching -- to achieve high performance and scalability. This demonstrated approach of database sharing combined with effective task scheduling should have broad ranging applications to other informatics-driven sciences.

  20. Protection Conferred by recombinant Yersinia pestis Antigens Produced by a Rapid and Highly Scalable Plant Expression System

    DTIC Science & Technology

    2006-01-24

    variety of molecules have been successfully expressed in plants , including peptides (14), human proteins and enzymes (15), viral and bacterial...contaminated by the Rubisco large subunit, which is very similar in size to F1-V. Analysis of Purified Plant -Produced Antigens. Western blots were...Protection conferred by recombinant Yersinia pestis antigens produced by a rapid and highly scalable plant expression system Luca Santi*†, Anatoli

  1. Scalable High-Performance Image Registration Framework by Unsupervised Deep Feature Representations Learning.

    PubMed

    Wu, Guorong; Kim, Minjeong; Wang, Qian; Munsell, Brent C; Shen, Dinggang

    2016-07-01

    Feature selection is a critical step in deformable image registration. In particular, selecting the most discriminative features that accurately and concisely describe complex morphological patterns in image patches improves correspondence detection, which in turn improves image registration accuracy. Furthermore, since more and more imaging modalities are being invented to better identify morphological changes in medical imaging data, the development of deformable image registration method that scales well to new image modalities or new image applications with little to no human intervention would have a significant impact on the medical image analysis community. To address these concerns, a learning-based image registration framework is proposed that uses deep learning to discover compact and highly discriminative features upon observed imaging data. Specifically, the proposed feature selection method uses a convolutional stacked autoencoder to identify intrinsic deep feature representations in image patches. Since deep learning is an unsupervised learning method, no ground truth label knowledge is required. This makes the proposed feature selection method more flexible to new imaging modalities since feature representations can be directly learned from the observed imaging data in a very short amount of time. Using the LONI and ADNI imaging datasets, image registration performance was compared to two existing state-of-the-art deformable image registration methods that use handcrafted features. To demonstrate the scalability of the proposed image registration framework, image registration experiments were conducted on 7.0-T brain MR images. In all experiments, the results showed that the new image registration framework consistently demonstrated more accurate registration results when compared to state of the art.

  2. Personalised Prescription of Scalable High Intensity Interval Training to Inactive Female Adults of Different Ages

    PubMed Central

    Mair, Jacqueline L.

    2016-01-01

    Stepping is a convenient form of scalable high-intensity interval training (HIIT) that may lead to health benefits. However, the accurate personalised prescription of stepping is hampered by a lack of evidence on optimal stepping cadences and step heights for various populations. This study examined the acute physiological responses to stepping exercise at various heights and cadences in young (n = 14) and middle-aged (n = 14) females in order to develop an equation that facilitates prescription of stepping at targeted intensities. Participants completed a step test protocol consisting of randomised three-minute bouts at different step cadences (80, 90, 100, 110 steps·min-1) and step heights (17, 25, 30, 34 cm). Aerobic demand and heart rate values were measured throughout. Resting metabolic rate was measured in order to develop female specific metabolic equivalents (METs) for stepping. Results revealed significant differences between age groups for METs and heart rate reserve, and within-group differences for METs, heart rate, and metabolic cost, at different step heights and cadences. At a given step height and cadence, middle-aged females were required to work at an intensity on average 1.9 ± 0.26 METs greater than the younger females. A prescriptive equation was developed to assess energy cost in METs using multilevel regression analysis with factors of step height, step cadence and age. Considering recent evidence supporting accumulated bouts of HIIT exercise for health benefits, this equation, which allows HIIT to be personally prescribed to inactive and sedentary women, has potential impact as a public health exercise prescription tool. PMID:26848956

  3. Implementation of scalable video coding deblocking filter from high-level SystemC description

    NASA Astrophysics Data System (ADS)

    Carballo, Pedro P.; Espino, Omar; Neris, Romén.; Hernández-Fernández, Pedro; Szydzik, Tomasz M.; Núñez, Antonio

    2013-05-01

    This paper describes key concepts in the design and implementation of a deblocking filter (DF) for a H.264/SVC video decoder. The DF supports QCIF and CIF video formats with temporal and spatial scalability. The design flow starts from a SystemC functional model and has been refined using high-level synthesis methodology to RTL microarchitecture. The process is guided with performance measurements (latency, cycle time, power, resource utilization) with the objective of assuring the quality of results of the final system. The functional model of the DF is created in an incremental way from the AVC DF model using OpenSVC source code as reference. The design flow continues with the logic synthesis and the implementation on the FPGA using various strategies. The final implementation is chosen among the implementations that meet the timing constraints. The DF is capable to run at 100 MHz, and macroblocks are processed in 6,500 clock cycles for a throughput of 130 fps for QCIF format and 37 fps for CIF format. The proposed architecture for the complete H.264/SVC decoder is composed of an OMAP 3530 SOC (ARM Cortex-A8 GPP + DSP) and the FPGA Virtex-5 acting as a coprocessor for DF implementation. The DF is connected to the OMAP SOC using the GPMC interface. A validation platform has been developed using the embedded PowerPC processor in the FPGA, composing a SoC that integrates the frame generation and visualization in a TFT screen. The FPGA implements both the DF core and a GPMC slave core. Both cores are connected to the PowerPC440 embedded processor using LocalLink interfaces. The FPGA also contains a local memory capable of storing information necessary to filter a complete frame and to store a decoded picture frame. The complete system is implemented in a Virtex5 FX70T device.

  4. Scalable High Performance Image Registration Framework by Unsupervised Deep Feature Representations Learning

    PubMed Central

    Wu, Guorong; Kim, Minjeong; Wang, Qian; Munsell, Brent C.

    2015-01-01

    Feature selection is a critical step in deformable image registration. In particular, selecting the most discriminative features that accurately and concisely describe complex morphological patterns in image patches improves correspondence detection, which in turn improves image registration accuracy. Furthermore, since more and more imaging modalities are being invented to better identify morphological changes in medical imaging data,, the development of deformable image registration method that scales well to new image modalities or new image applications with little to no human intervention would have a significant impact on the medical image analysis community. To address these concerns, a learning-based image registration framework is proposed that uses deep learning to discover compact and highly discriminative features upon observed imaging data. Specifically, the proposed feature selection method uses a convolutional stacked auto-encoder to identify intrinsic deep feature representations in image patches. Since deep learning is an unsupervised learning method, no ground truth label knowledge is required. This makes the proposed feature selection method more flexible to new imaging modalities since feature representations can be directly learned from the observed imaging data in a very short amount of time. Using the LONI and ADNI imaging datasets, image registration performance was compared to two existing state-of-the-art deformable image registration methods that use handcrafted features. To demonstrate the scalability of the proposed image registration framework image registration experiments were conducted on 7.0-tesla brain MR images. In all experiments, the results showed the new image registration framework consistently demonstrated more accurate registration results when compared to state-of-the-art. PMID:26552069

  5. A Scalable, Parallel Approach for Multi-Point, High-Fidelity Aerostructural Optimization of Aircraft Configurations

    NASA Astrophysics Data System (ADS)

    Kenway, Gaetan K. W.

    This thesis presents new tools and techniques developed to address the challenging problem of high-fidelity aerostructural optimization with respect to large numbers of design variables. A new mesh-movement scheme is developed that is both computationally efficient and sufficiently robust to accommodate large geometric design changes and aerostructural deformations. A fully coupled Newton-Krylov method is presented that accelerates the convergence of aerostructural systems and provides a 20% performance improvement over the traditional nonlinear block Gauss-Seidel approach and can handle more exible structures. A coupled adjoint method is used that efficiently computes derivatives for a gradient-based optimization algorithm. The implementation uses only machine accurate derivative techniques and is verified to yield fully consistent derivatives by comparing against the complex step method. The fully-coupled large-scale coupled adjoint solution method is shown to have 30% better performance than the segregated approach. The parallel scalability of the coupled adjoint technique is demonstrated on an Euler Computational Fluid Dynamics (CFD) model with more than 80 million state variables coupled to a detailed structural finite-element model of the wing with more than 1 million degrees of freedom. Multi-point high-fidelity aerostructural optimizations of a long-range wide-body, transonic transport aircraft configuration are performed using the developed techniques. The aerostructural analysis employs Euler CFD with a 2 million cell mesh and a structural finite element model with 300 000 DOF. Two design optimization problems are solved: one where takeoff gross weight is minimized, and another where fuel burn is minimized. Each optimization uses a multi-point formulation with 5 cruise conditions and 2 maneuver conditions. The optimization problems have 476 design variables are optimal results are obtained within 36 hours of wall time using 435 processors. The TOGW

  6. Ultra-High Performance, High-Temperature Superconducting Wires via Cost-effective, Scalable, Co-evaporation Process

    SciTech Connect

    Kim, Dr. Hosup; Oh, Sang-Soo; Ha, HS; Youm, D; Moon, SH; Kim, JH; Heo, YU; Dou, SX; Wee, Sung Hun; Goyal, Amit

    2014-01-01

    Long-length, high-temperature superconducting (HTS) wires capable of carrying high critical current, Ic, are required for a wide range of applications. Here, we report extremely high performance HTS wires based on 5 m thick SmBa2Cu3O7- (SmBCO) single layer films on textured metallic templates. SmBCO layer wires over 20 meters long were deposited by a cost-effective, scalable co-evaporation process using a batch-type drum in a dual chamber. All deposition parameters influencing the composition, phase, and texture of the films were optimized via a unique combinatorial method that is broadly applicable for co-evaporation of other promising complex materials containing several cations. Thick SmBCO layers deposited under optimized conditions exhibit excellent cube-on-cube epitaxy. Such excellent structural epitaxy over the entire thickness results in exceptionally high Ic performance, with average Ic over 1000 A/cm for the entire 22 meter long wire and maximum Ic over 1,500 A/cm for a short 12 cm long tape. The Ic values reported in this work are the highest values ever reported from any lengths of cuprate-based HTS wire or conductor.

  7. Ultra-High Performance, High-Temperature Superconducting Wires via Cost-effective, Scalable, Co-evaporation Process

    PubMed Central

    Kim, Ho-Sup; Oh, Sang-Soo; Ha, Hong-Soo; Youm, Dojun; Moon, Seung-Hyun; Kim, Jung Ho; Dou, Shi Xue; Heo, Yoon-Uk; Wee, Sung-Hun; Goyal, Amit

    2014-01-01

    Long-length, high-temperature superconducting (HTS) wires capable of carrying high critical current, Ic, are required for a wide range of applications. Here, we report extremely high performance HTS wires based on 5 μm thick SmBa2Cu3O7 − δ (SmBCO) single layer films on textured metallic templates. SmBCO layer wires over 20 meters long were deposited by a cost-effective, scalable co-evaporation process using a batch-type drum in a dual chamber. All deposition parameters influencing the composition, phase, and texture of the films were optimized via a unique combinatorial method that is broadly applicable for co-evaporation of other promising complex materials containing several cations. Thick SmBCO layers deposited under optimized conditions exhibit excellent cube-on-cube epitaxy. Such excellent structural epitaxy over the entire thickness results in exceptionally high Ic performance, with average Ic over 1,000 A/cm-width for the entire 22 meter long wire and maximum Ic over 1,500 A/cm-width for a short 12 cm long tape. The Ic values reported in this work are the highest values ever reported from any lengths of cuprate-based HTS wire or conductor. PMID:24752189

  8. Highly scalable, atomically thin WSe2 grown via metal-organic chemical vapor deposition.

    PubMed

    Eichfeld, Sarah M; Hossain, Lorraine; Lin, Yu-Chuan; Piasecki, Aleksander F; Kupp, Benjamin; Birdwell, A Glen; Burke, Robert A; Lu, Ning; Peng, Xin; Li, Jie; Azcatl, Angelica; McDonnell, Stephen; Wallace, Robert M; Kim, Moon J; Mayer, Theresa S; Redwing, Joan M; Robinson, Joshua A

    2015-02-24

    Tungsten diselenide (WSe2) is a two-dimensional material that is of interest for next-generation electronic and optoelectronic devices due to its direct bandgap of 1.65 eV in the monolayer form and excellent transport properties. However, technologies based on this 2D material cannot be realized without a scalable synthesis process. Here, we demonstrate the first scalable synthesis of large-area, mono and few-layer WSe2 via metal-organic chemical vapor deposition using tungsten hexacarbonyl (W(CO)6) and dimethylselenium ((CH3)2Se). In addition to being intrinsically scalable, this technique allows for the precise control of the vapor-phase chemistry, which is unobtainable using more traditional oxide vaporization routes. We show that temperature, pressure, Se:W ratio, and substrate choice have a strong impact on the ensuing atomic layer structure, with optimized conditions yielding >8 μm size domains. Raman spectroscopy, atomic force microscopy (AFM), and cross-sectional transmission electron microscopy (TEM) confirm crystalline monoto-multilayer WSe2 is achievable. Finally, TEM and vertical current/voltage transport provide evidence that a pristine van der Waals gap exists in WSe2/graphene heterostructures.

  9. Scalable high-power redox capacitors with aligned nanoforests of crystalline MnO₂ nanorods by high voltage electrophoretic deposition.

    PubMed

    Santhanagopalan, Sunand; Balram, Anirudh; Meng, Dennis Desheng

    2013-03-26

    It is commonly perceived that reduction-oxidation (redox) capacitors have to sacrifice power density to achieve higher energy density than carbon-based electric double layer capacitors. In this work, we report the synergetic advantages of combining the high crystallinity of hydrothermally synthesized α-MnO2 nanorods with alignment for high performance redox capacitors. Such an approach is enabled by high voltage electrophoretic deposition (HVEPD) technology which can obtain vertically aligned nanoforests with great process versatility. The scalable nanomanufacturing process is demonstrated by roll-printing an aligned forest of α-MnO2 nanorods on a large flexible substrate (1 inch by 1 foot). The electrodes show very high power density (340 kW/kg at an energy density of 4.7 Wh/kg) and excellent cyclability (over 92% capacitance retention over 2000 cycles). Pretreatment of the substrate and use of a conductive holding layer have also been shown to significantly reduce the contact resistance between the aligned nanoforests and the substrates. High areal specific capacitances of around 8500 μF/cm(2) have been obtained for each electrode with a two-electrode device configuration. Over 93% capacitance retention was observed when the cycling current densities were increased from 0.25 to 10 mA/cm(2), indicating high rate capabilities of the fabricated electrodes and resulting in the very high attainable power density. The high performance of the electrodes is attributed to the crystallographic structure, 1D morphology, aligned orientation, and low contact resistance.

  10. Probabilistic methods in a study of trip setpoints

    SciTech Connect

    Kaulitz, D. E.

    2012-07-01

    Most early vintage Boiling Water Reactors have a high head and high capacity High Pressure Coolant Injection (HPCI) pump to keep the core covered following a loss of coolant accident (LOCA). However, the protection afforded by the HPCI pump for mitigating a LOCA introduces the potential that a spurious start of the HPCI pump could oversupply the reactor vessel and lead to an automatic trip of the main turbine due to high water level. A turbine trip and associated increase in moderator density could challenge the bases of fuel integrity operating limits. To prevent turbine trip during spurious operation of the HPCI pump, the reactor protection system includes instrumentation and logic to sense high water level and automatically trip the HPCI pump prior to reaching the turbine trip setpoint. This paper describes an analysis that was performed to determine if existing reactor vessel water level trip instrumentation, logic and setpoints result in a high probability that the HPCI pump will trip prior to actuation of the turbine trip. Using nominal values for the initial water level and for the HPCI pump and turbine trip setpoints, and using the probability distribution functions for measurement uncertainty in these setpoints, a Monte Carlo simulation was employed to determine probabilities of successfully tripping the HPCI pump prior to tripping of the turbine. The results of the analysis established that the existing setpoints, instrumentation and logic would be expected to reliably prevent a trip of the main turbine. (authors)

  11. Analysis of the scalability of diffraction-limited fiber lasers and amplifiers to high average power.

    PubMed

    Dawson, Jay W; Messerly, Michael J; Beach, Raymond J; Shverdin, Miroslav Y; Stappaerts, Eddy A; Sridharan, Arun K; Pax, Paul H; Heebner, John E; Siders, Craig W; Barty, C P J

    2008-08-18

    We analyze the scalability of diffraction-limited fiber lasers considering thermal, non-linear, damage and pump coupling limits as well as fiber mode field diameter (MFD) restrictions. We derive new general relationships based upon practical considerations. Our analysis shows that if the fiber's MFD could be increased arbitrarily, 36 kW of power could be obtained with diffraction-limited quality from a fiber laser or amplifier. This power limit is determined by thermal and non-linear limits that combine to prevent further power scaling, irrespective of increases in mode size. However, limits to the scaling of the MFD may restrict fiber lasers to lower output powers.

  12. Simulating chemical energies to high precision with fully-scalable quantum algorithms on superconducting qubits

    NASA Astrophysics Data System (ADS)

    O'Malley, Peter; Babbush, Ryan; Kivlichan, Ian; Romero, Jhonathan; McClean, Jarrod; Tranter, Andrew; Barends, Rami; Kelly, Julian; Chen, Yu; Chen, Zijun; Jeffrey, Evan; Fowler, Austin; Megrant, Anthony; Mutus, Josh; Neill, Charles; Quintana, Christopher; Roushan, Pedram; Sank, Daniel; Vainsencher, Amit; Wenner, James; White, Theodore; Love, Peter; Aspuru-Guzik, Alan; Neven, Hartmut; Martinis, John

    Quantum simulations of molecules have the potential to calculate industrially-important chemical parameters beyond the reach of classical methods with relatively modest quantum resources. Recent years have seen dramatic progress both superconducting qubits and quantum chemistry algorithms. Here, we present experimental demonstrations of two fully-scalable algorithms for finding the dissociation energy of hydrogen: the variational quantum eigensolver and iterative phase estimation. This represents the first calculation of a dissociation energy to chemical accuracy with a non-precompiled algorithm. These results show the promise of chemistry as the ``killer app'' for quantum computers, even before the advent of full error-correction.

  13. A Biomes Field Trip.

    ERIC Educational Resources Information Center

    Leonard, William H.; And Others

    1983-01-01

    Describes a field trip designed to give students opportunities to experience relevant data leading to concepts in biogeography. Suggests that teachers (including college instructors) adapt the areas studied and procedures used to their own locations. Includes a suggested field trip handout. (JN)

  14. BOCES Field Trip Guide.

    ERIC Educational Resources Information Center

    Nassau County Board of Cooperative Educational Services, Westbury, NY.

    An effective and comprehensive guide to possible field trips for Nassau County (New York) elementary and secondary students covers places of interest in Nassau and Suffolk counties and in New York City. Recognizing that field trips can have great importance in the learning process, especially if they are directly related to the curriculum, the…

  15. Geological Field Trip Guidebooks

    ERIC Educational Resources Information Center

    Wallace, Harriet E.

    1978-01-01

    Geological field trip guidebooks, developed for use during a field trip or field conference, are considered ephemeral publications by their compilers and publishers. Too few copies are printed and little attention is paid to bibliographic format and information. These difficulties are discussed and recommendations are made to alleviate the…

  16. Three-dimensional Finite Element Formulation and Scalable Domain Decomposition for High Fidelity Rotor Dynamic Analysis

    NASA Technical Reports Server (NTRS)

    Datta, Anubhav; Johnson, Wayne R.

    2009-01-01

    This paper has two objectives. The first objective is to formulate a 3-dimensional Finite Element Model for the dynamic analysis of helicopter rotor blades. The second objective is to implement and analyze a dual-primal iterative substructuring based Krylov solver, that is parallel and scalable, for the solution of the 3-D FEM analysis. The numerical and parallel scalability of the solver is studied using two prototype problems - one for ideal hover (symmetric) and one for a transient forward flight (non-symmetric) - both carried out on up to 48 processors. In both hover and forward flight conditions, a perfect linear speed-up is observed, for a given problem size, up to the point of substructure optimality. Substructure optimality and the linear parallel speed-up range are both shown to depend on the problem size as well as on the selection of the coarse problem. With a larger problem size, linear speed-up is restored up to the new substructure optimality. The solver also scales with problem size - even though this conclusion is premature given the small prototype grids considered in this study.

  17. A scalable strategy for high-throughput GFP tagging of endogenous human proteins

    PubMed Central

    Leonetti, Manuel D.; Sekine, Sayaka; Kamiyama, Daichi; Weissman, Jonathan S.; Huang, Bo

    2016-01-01

    A central challenge of the postgenomic era is to comprehensively characterize the cellular role of the ∼20,000 proteins encoded in the human genome. To systematically study protein function in a native cellular background, libraries of human cell lines expressing proteins tagged with a functional sequence at their endogenous loci would be very valuable. Here, using electroporation of Cas9 nuclease/single-guide RNA ribonucleoproteins and taking advantage of a split-GFP system, we describe a scalable method for the robust, scarless, and specific tagging of endogenous human genes with GFP. Our approach requires no molecular cloning and allows a large number of cell lines to be processed in parallel. We demonstrate the scalability of our method by targeting 48 human genes and show that the resulting GFP fluorescence correlates with protein expression levels. We next present how our protocols can be easily adapted for the tagging of a given target with GFP repeats, critically enabling the study of low-abundance proteins. Finally, we show that our GFP tagging approach allows the biochemical isolation of native protein complexes for proteomic studies. Taken together, our results pave the way for the large-scale generation of endogenously tagged human cell lines for the proteome-wide analysis of protein localization and interaction networks in a native cellular context. PMID:27274053

  18. Developing Defined and Scalable 3D Culture Systems for Culturing Human Pluripotent Stem Cells at High Densities.

    PubMed

    Lei, Yuguo; Jeong, Daeun; Xiao, Jifang; Schaffer, David V

    2014-06-01

    Human pluripotent stem cells (hPSCs) - including embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) - are very promising candidates for cell therapies, tissue engineering, high throughput pharmacology screens, and toxicity testing. These applications require large numbers of high quality cells; however, scalable production of human pluripotent stem cells and their derivatives at a high density and under well-defined conditions has been a challenge. We recently reported a simple, efficient, fully defined, scalable, and good manufacturing practice (GMP) compatible 3D culture system based on a thermoreversible hydrogel for hPSC expansion and differentiation. Here, we describe additional design rationale and characterization of this system. For instance, we have determined that culturing hPSCs as a suspension in a liquid medium can exhibit lower volumetric yields due to cell agglomeration and possible shear force-induced cell loss. By contrast, using hydrogels as 3D scaffolds for culturing hPSCs reduces aggregation and may insulate from shear forces. Additionally, hydrogel-based 3D culture systems can support efficient hPSC expansion and differentiation at a high density if compatible with hPSC biology. Finally, there are considerable opportunities for future development to further enhance hydrogel-based 3D culture systems for producing hPSCs and their progeny.

  19. Scalable coherent interface

    SciTech Connect

    Alnaes, K.; Kristiansen, E.H. ); Gustavson, D.B. ); James, D.V. )

    1990-01-01

    The Scalable Coherent Interface (IEEE P1596) is establishing an interface standard for very high performance multiprocessors, supporting a cache-coherent-memory model scalable to systems with up to 64K nodes. This Scalable Coherent Interface (SCI) will supply a peak bandwidth per node of 1 GigaByte/second. The SCI standard should facilitate assembly of processor, memory, I/O and bus bridge cards from multiple vendors into massively parallel systems with throughput far above what is possible today. The SCI standard encompasses two levels of interface, a physical level and a logical level. The physical level specifies electrical, mechanical and thermal characteristics of connectors and cards that meet the standard. The logical level describes the address space, data transfer protocols, cache coherence mechanisms, synchronization primitives and error recovery. In this paper we address logical level issues such as packet formats, packet transmission, transaction handshake, flow control, and cache coherence. 11 refs., 10 figs.

  20. SAME4HPC: A Promising Approach in Building a Scalable and Mobile Environment for High-Performance Computing

    SciTech Connect

    Karthik, Rajasekar

    2014-01-01

    In this paper, an architecture for building Scalable And Mobile Environment For High-Performance Computing with spatial capabilities called SAME4HPC is described using cutting-edge technologies and standards such as Node.js, HTML5, ECMAScript 6, and PostgreSQL 9.4. Mobile devices are increasingly becoming powerful enough to run high-performance apps. At the same time, there exist a significant number of low-end and older devices that rely heavily on the server or the cloud infrastructure to do the heavy lifting. Our architecture aims to support both of these types of devices to provide high-performance and rich user experience. A cloud infrastructure consisting of OpenStack with Ubuntu, GeoServer, and high-performance JavaScript frameworks are some of the key open-source and industry standard practices that has been adopted in this architecture.

  1. Field Trips: Tradition in Jeopardy

    ERIC Educational Resources Information Center

    Wheeler, Ginger

    2011-01-01

    The school field trip: something fun, different, exciting, exhausting--a break from the school day grind. But the field trip has ramifications beyond just getting out of school for the day. For students, the field trip is to the classroom what the big game is to athletes. For museums and other attractions, the field trip is a way to cultivate…

  2. High power impulse magnetron sputtering and related discharges: scalable plasma sources for plasma-based ion implantation and deposition

    SciTech Connect

    Anders, Andre

    2009-09-01

    High power impulse magnetron sputtering (HIPIMS) and related self-sputtering techniques are reviewed from a viewpoint of plasma-based ion implantation and deposition (PBII&D). HIPIMS combines the classical, scalable sputtering technology with pulsed power, which is an elegant way of ionizing the sputtered atoms. Related approaches, such as sustained self-sputtering, are also considered. The resulting intense flux of ions to the substrate consists of a mixture of metal and gas ions when using a process gas, or of metal ions only when using `gasless? or pure self-sputtering. In many respects, processing with HIPIMS plasmas is similar to processing with filtered cathodic arc plasmas, though the former is easier to scale to large areas. Both ion implantation and etching (high bias voltage, without deposition) and thin film deposition (low bias, or bias of low duty cycle) have been demonstrated.

  3. Parallel grid library with adaptive mesh refinement for development of highly scalable simulations

    NASA Astrophysics Data System (ADS)

    Honkonen, I.; von Alfthan, S.; Sandroos, A.; Janhunen, P.; Palmroth, M.

    2012-04-01

    As the single CPU core performance is saturating while the number of cores in the fastest supercomputers increases exponentially, the parallel performance of simulations on distributed memory machines is crucial. At the same time, utilizing efficiently the large number of available cores presents a challenge, especially in simulations with run-time adaptive mesh refinement. We have developed a generic grid library (dccrg) aimed at finite volume simulations that is easy to use and scales well up to tens of thousands of cores. The grid has several attractive features: It 1) allows an arbitrary C++ class or structure to be used as cell data; 2) provides a simple interface for adaptive mesh refinement during a simulation; 3) encapsulates the details of MPI communication when updating the data of neighboring cells between processes; and 4) provides a simple interface to run-time load balancing, e.g. domain decomposition, through the Zoltan library. Dccrg is freely available for anyone to use, study and modify under the GNU Lesser General Public License v3. We will present the implementation of dccrg, simple and advanced usage examples and scalability results on various supercomputers and problems.

  4. SYMNET: an optical interconnection network for scalable high-performance symmetric multiprocessors.

    PubMed

    Louri, Ahmed; Kodi, Avinash Karanth

    2003-06-10

    We address the primary limitation of the bandwidth to satisfy the demands for address transactions in future cache-coherent symmetric multiprocessors (SMPs). It is widely known that the bus speed and the coherence overhead limit the snoop/address bandwidth needed to broadcast address transactions to all processors. As a solution, we propose a scalable address subnetwork called symmetric multiprocessor network (SYMNET) in which address requests and snoop responses of SMPs are implemented optically. SYMNET not only has the ability to pipeline address requests, but also multiple address requests from different processors can propagate through the address subnetwork simultaneously. This is in contrast with all electrical bus-based SMPs, where only a single request is broadcast on the physical address bus at any given point in time. The simultaneous propagation of multiple address requests in SYMNET increases the available address bandwidth and lowers the latency of the network, but the preservation of cache coherence can no longer be maintained with the usual fast snooping protocols. A modified snooping cache-coherence protocol, coherence in SYMNET (COSYM) is introduced to solve the coherence problem. We evaluated SYMNET with a subset of Splash-2 benchmarks and compared it with the electrical bus-based MOESI (modified, owned, exclusive, shared, invalid) protocol. Our simulation studies have shown a 5-66% improvement in execution time for COSYM as compared with MOESI for various applications. Simulations have also shown that the average latency for a transaction to complete by use of COSYM protocol was 5-78% better than the MOESI protocol. SYMNET can scale up to hundreds of processors while still using fast snooping-based cache-coherence protocols, and additional performance gains may be attained with further improvement in optical device technology.

  5. Churchill: an ultra-fast, deterministic, highly scalable and balanced parallelization strategy for the discovery of human genetic variation in clinical and population-scale genomics.

    PubMed

    Kelly, Benjamin J; Fitch, James R; Hu, Yangqiu; Corsmeier, Donald J; Zhong, Huachun; Wetzel, Amy N; Nordquist, Russell D; Newsom, David L; White, Peter

    2015-01-20

    While advances in genome sequencing technology make population-scale genomics a possibility, current approaches for analysis of these data rely upon parallelization strategies that have limited scalability, complex implementation and lack reproducibility. Churchill, a balanced regional parallelization strategy, overcomes these challenges, fully automating the multiple steps required to go from raw sequencing reads to variant discovery. Through implementation of novel deterministic parallelization techniques, Churchill allows computationally efficient analysis of a high-depth whole genome sample in less than two hours. The method is highly scalable, enabling full analysis of the 1000 Genomes raw sequence dataset in a week using cloud resources. http://churchill.nchri.org/.

  6. An adaptive scan of high frequency subbands for dyadic intra frame in MPEG4-AVC/H.264 scalable video coding

    NASA Astrophysics Data System (ADS)

    Shahid, Z.; Chaumont, M.; Puech, W.

    2009-01-01

    This paper develops a new adaptive scanning methodology for intra frame scalable coding framework based on a subband/wavelet(DWTSB) coding approach for MPEG-4 AVC/H.264 scalable video coding (SVC). It attempts to take advantage of the prior knowledge of the frequencies which are present in different higher frequency subbands. We propose dyadic intra frame coding method with adaptive scan (DWTSB-AS) for each subband as traditional zigzag scan is not suitable for high frequency subbands. Thus, by just modification of the scan order of the intra frame scalable coding framework of H.264, we can get better compression. The proposed algorithm has been theoretically justified and is thoroughly evaluated against the current SVC test model JSVM and DWTSB through extensive coding experiments for scalable coding of intra frame. The simulation results show the proposed scanning algorithm consistently outperforms JSVM and DWTSB in PSNR performance. This results in extra compression for intra frames, along with spatial scalability. Thus Image and video coding applications, traditionally serviced by separate coders, can be efficiently provided by an integrated coding system.

  7. SciSpark: Highly Interactive and Scalable Model Evaluation and Climate Metrics

    NASA Astrophysics Data System (ADS)

    Wilson, B. D.; Palamuttam, R. S.; Mogrovejo, R. M.; Whitehall, K. D.; Mattmann, C. A.; Verma, R.; Waliser, D. E.; Lee, H.

    2015-12-01

    Remote sensing data and climate model output are multi-dimensional arrays of massive sizes locked away in heterogeneous file formats (HDF5/4, NetCDF 3/4) and metadata models (HDF-EOS, CF) making it difficult to perform multi-stage, iterative science processing since each stage requires writing and reading data to and from disk. We are developing a lightning fast Big Data technology called SciSpark based on ApacheTM Spark under a NASA AIST grant (PI Mattmann). Spark implements the map-reduce paradigm for parallel computing on a cluster, but emphasizes in-memory computation, "spilling" to disk only as needed, and so outperforms the disk-based ApacheTM Hadoop by 100x in memory and by 10x on disk. SciSpark will enable scalable model evaluation by executing large-scale comparisons of A-Train satellite observations to model grids on a cluster of 10 to 1000 compute nodes. This 2nd generation capability for NASA's Regional Climate Model Evaluation System (RCMES) will compute simple climate metrics at interactive speeds, and extend to quite sophisticated iterative algorithms such as machine-learning based clustering of temperature PDFs, and even graph-based algorithms for searching for Mesocale Convective Complexes. We have implemented a parallel data ingest capability in which the user specifies desired variables (arrays) as several time-sorted lists of URL's (i.e. using OPeNDAP model.nc?varname, or local files). The specified variables are partitioned by time/space and then each Spark node pulls its bundle of arrays into memory to begin a computation pipeline. We also investigated the performance of several N-dim. array libraries (scala breeze, java jblas & netlib-java, and ND4J). We are currently developing science codes using ND4J and studying memory behavior on the JVM. On the pyspark side, many of our science codes already use the numpy and SciPy ecosystems. The talk will cover: the architecture of SciSpark, the design of the scientific RDD (sRDD) data structure, our

  8. SciSpark: Highly Interactive and Scalable Model Evaluation and Climate Metrics

    NASA Astrophysics Data System (ADS)

    Wilson, B. D.; Mattmann, C. A.; Waliser, D. E.; Kim, J.; Loikith, P.; Lee, H.; McGibbney, L. J.; Whitehall, K. D.

    2014-12-01

    Remote sensing data and climate model output are multi-dimensional arrays of massive sizes locked away in heterogeneous file formats (HDF5/4, NetCDF 3/4) and metadata models (HDF-EOS, CF) making it difficult to perform multi-stage, iterative science processing since each stage requires writing and reading data to and from disk. We are developing a lightning fast Big Data technology called SciSpark based on ApacheTM Spark. Spark implements the map-reduce paradigm for parallel computing on a cluster, but emphasizes in-memory computation, "spilling" to disk only as needed, and so outperforms the disk-based ApacheTM Hadoop by 100x in memory and by 10x on disk, and makes iterative algorithms feasible. SciSpark will enable scalable model evaluation by executing large-scale comparisons of A-Train satellite observations to model grids on a cluster of 100 to 1000 compute nodes. This 2nd generation capability for NASA's Regional Climate Model Evaluation System (RCMES) will compute simple climate metrics at interactive speeds, and extend to quite sophisticated iterative algorithms such as machine-learning (ML) based clustering of temperature PDFs, and even graph-based algorithms for searching for Mesocale Convective Complexes. The goals of SciSpark are to: (1) Decrease the time to compute comparison statistics and plots from minutes to seconds; (2) Allow for interactive exploration of time-series properties over seasons and years; (3) Decrease the time for satellite data ingestion into RCMES to hours; (4) Allow for Level-2 comparisons with higher-order statistics or PDF's in minutes to hours; and (5) Move RCMES into a near real time decision-making platform. We will report on: the architecture and design of SciSpark, our efforts to integrate climate science algorithms in Python and Scala, parallel ingest and partitioning (sharding) of A-Train satellite observations from HDF files and model grids from netCDF files, first parallel runs to compute comparison statistics and PDF

  9. Scalability of a Low-Cost Multi-Teraflop Linux Cluster for High-End Classical Atomistic and Quantum Mechanical Simulations

    NASA Technical Reports Server (NTRS)

    Kikuchi, Hideaki; Kalia, Rajiv K.; Nakano, Aiichiro; Vashishta, Priya; Shimojo, Fuyuki; Saini, Subhash

    2003-01-01

    Scalability of a low-cost, Intel Xeon-based, multi-Teraflop Linux cluster is tested for two high-end scientific applications: Classical atomistic simulation based on the molecular dynamics method and quantum mechanical calculation based on the density functional theory. These scalable parallel applications use space-time multiresolution algorithms and feature computational-space decomposition, wavelet-based adaptive load balancing, and spacefilling-curve-based data compression for scalable I/O. Comparative performance tests are performed on a 1,024-processor Linux cluster and a conventional higher-end parallel supercomputer, 1,184-processor IBM SP4. The results show that the performance of the Linux cluster is comparable to that of the SP4. We also study various effects, such as the sharing of memory and L2 cache among processors, on the performance.

  10. High-flux ionic diodes, ionic transistors and ionic amplifiers based on external ion concentration polarization by an ion exchange membrane: a new scalable ionic circuit platform.

    PubMed

    Sun, Gongchen; Senapati, Satyajyoti; Chang, Hsueh-Chia

    2016-04-07

    A microfluidic ion exchange membrane hybrid chip is fabricated using polymer-based, lithography-free methods to achieve ionic diode, transistor and amplifier functionalities with the same four-terminal design. The high ionic flux (>100 μA) feature of the chip can enable a scalable integrated ionic circuit platform for micro-total-analytical systems.

  11. High-flux ionic diodes, ionic transistors and ionic amplifiers based on external ion concentration polarization by an ion exchange membrane: a new scalable ionic circuit platform†

    PubMed Central

    Sun, Gongchen; Senapati, Satyajyoti

    2016-01-01

    A microfluidic-ion exchange membrane hybrid chip is fabricated by polymer-based, lithography-free methods to achieve ionic diode, transistor and amplifier functionalities with the same four-terminal design. The high ionic flux (> 100 μA) feature of the chip can enable a scalable integrated ionic circuit platform for micro-total-analytical systems. PMID:26960551

  12. Virtual Field Trips.

    ERIC Educational Resources Information Center

    Walter, Virginia A.

    1997-01-01

    Virtual field trips can provide experiences beyond the reach of average K-12 students. Describes multimedia products for school use: Africa Trail, Dinosaur Hunter, Louvre Museum, Magic School Bus Explores the Rainforest, and Up to the Himalayas: Kingdoms in the Clouds and provides book and Internet connections for additional learning, highlighting…

  13. Administration Trip Books

    DTIC Science & Technology

    2007-11-02

    Plan. (h) Army Community of Excellence. (i) Child development services. k. The Assistant Secretary of the Army for Manpower and Reserve Affairs ( ASAM ...RA) will — (1) Provide information as requested when the information falls under the purview of the ASAM &RA. (2) Provide recurring trip book

  14. Scalable Work Stealing

    SciTech Connect

    Dinan, James S.; Larkins, D. B.; Sadayappan, Ponnuswamy; Krishnamoorthy, Sriram; Nieplocha, Jaroslaw

    2009-11-14

    Irregular and dynamic parallel applications pose significant challenges to achieving scalable performance on large-scale multicore clusters. These applications often require ongoing, dynamic load balancing in order to maintain efficiency. While effective at small scale, centralized load balancing schemes quickly become a bottleneck on large-scale clusters. Work stealing is a popular approach to distributed dynamic load balancing; however its performance on large-scale clusters is not well understood. Prior work on work stealing has largely focused on shared memory machines. In this work we investigate the design and scalability of work stealing on modern distributed memory systems. We demonstrate high efficiency and low overhead when scaling to 8,192 processors for three benchmark codes: a producer-consumer benchmark, the unbalanced tree search benchmark, and a multiresolution analysis kernel.

  15. Computer Based Virtual Field Trips.

    ERIC Educational Resources Information Center

    Clark, Kenneth F.; Hosticka, Alice; Schriver, Martha; Bedell, Jackie

    This paper discusses computer based virtual field trips that use technologies commonly found in public schools in the United States. The discussion focuses on the advantages of both using and creating these field trips for an instructional situation. A virtual field trip to Cumberland Island National Seashore, St. Marys, Georgia is used as a point…

  16. A peripheral component interconnect express-based scalable and highly integrated pulsed spectrometer for solution state dynamic nuclear polarization

    SciTech Connect

    He, Yugui; Liu, Chaoyang; Feng, Jiwen; Wang, Dong; Chen, Fang; Liu, Maili; Zhang, Zhi; Wang, Chao

    2015-08-15

    High sensitivity, high data rates, fast pulses, and accurate synchronization all represent challenges for modern nuclear magnetic resonance spectrometers, which make any expansion or adaptation of these devices to new techniques and experiments difficult. Here, we present a Peripheral Component Interconnect Express (PCIe)-based highly integrated distributed digital architecture pulsed spectrometer that is implemented with electron and nucleus double resonances and is scalable specifically for broad dynamic nuclear polarization (DNP) enhancement applications, including DNP-magnetic resonance spectroscopy/imaging (DNP-MRS/MRI). The distributed modularized architecture can implement more transceiver channels flexibly to meet a variety of MRS/MRI instrumentation needs. The proposed PCIe bus with high data rates can significantly improve data transmission efficiency and communication reliability and allow precise control of pulse sequences. An external high speed double data rate memory chip is used to store acquired data and pulse sequence elements, which greatly accelerates the execution of the pulse sequence, reduces the TR (time of repetition) interval, and improves the accuracy of TR in imaging sequences. Using clock phase-shift technology, we can produce digital pulses accurately with high timing resolution of 1 ns and narrow widths of 4 ns to control the microwave pulses required by pulsed DNP and ensure overall system synchronization. The proposed spectrometer is proved to be both feasible and reliable by observation of a maximum signal enhancement factor of approximately −170 for {sup 1}H, and a high quality water image was successfully obtained by DNP-enhanced spin-echo {sup 1}H MRI at 0.35 T.

  17. A peripheral component interconnect express-based scalable and highly integrated pulsed spectrometer for solution state dynamic nuclear polarization

    NASA Astrophysics Data System (ADS)

    He, Yugui; Feng, Jiwen; Zhang, Zhi; Wang, Chao; Wang, Dong; Chen, Fang; Liu, Maili; Liu, Chaoyang

    2015-08-01

    High sensitivity, high data rates, fast pulses, and accurate synchronization all represent challenges for modern nuclear magnetic resonance spectrometers, which make any expansion or adaptation of these devices to new techniques and experiments difficult. Here, we present a Peripheral Component Interconnect Express (PCIe)-based highly integrated distributed digital architecture pulsed spectrometer that is implemented with electron and nucleus double resonances and is scalable specifically for broad dynamic nuclear polarization (DNP) enhancement applications, including DNP-magnetic resonance spectroscopy/imaging (DNP-MRS/MRI). The distributed modularized architecture can implement more transceiver channels flexibly to meet a variety of MRS/MRI instrumentation needs. The proposed PCIe bus with high data rates can significantly improve data transmission efficiency and communication reliability and allow precise control of pulse sequences. An external high speed double data rate memory chip is used to store acquired data and pulse sequence elements, which greatly accelerates the execution of the pulse sequence, reduces the TR (time of repetition) interval, and improves the accuracy of TR in imaging sequences. Using clock phase-shift technology, we can produce digital pulses accurately with high timing resolution of 1 ns and narrow widths of 4 ns to control the microwave pulses required by pulsed DNP and ensure overall system synchronization. The proposed spectrometer is proved to be both feasible and reliable by observation of a maximum signal enhancement factor of approximately -170 for 1H, and a high quality water image was successfully obtained by DNP-enhanced spin-echo 1H MRI at 0.35 T.

  18. Scalable shear-exfoliation of high-quality phosphorene nanoflakes with reliable electrochemical cycleability in nano batteries

    NASA Astrophysics Data System (ADS)

    Xu, Feng; Ge, Binghui; Chen, Jing; Nathan, Arokia; Xin, Linhuo L.; Ma, Hongyu; Min, Huihua; Zhu, Chongyang; Xia, Weiwei; Li, Zhengrui; Li, Shengli; Yu, Kaihao; Wu, Lijun; Cui, Yiping; Sun, Litao; Zhu, Yimei

    2016-06-01

    Atomically thin black phosphorus (called phosphorene) holds great promise as an alternative to graphene and other two-dimensional transition-metal dichalcogenides as an anode material for lithium-ion batteries (LIBs). However, bulk black phosphorus (BP) suffers from rapid capacity fading and poor rechargeable performance. This work reports for the first time the use of in situ transmission electron microscopy (TEM) to construct nanoscale phosphorene LIBs. This enables direct visualization of the mechanisms underlying capacity fading in thick multilayer phosphorene through real-time capture of delithiation-induced structural decomposition, which serves to reduce electrical conductivity thus causing irreversibility of the lithiated phases. We further demonstrate that few-layer-thick phosphorene successfully circumvents the structural decomposition and holds superior structural restorability, even when subject to multi-cycle lithiation/delithiation processes and concomitant huge volume expansion. This finding provides breakthrough insights into thickness-dependent lithium diffusion kinetics in phosphorene. More importantly, a scalable liquid-phase shear exfoliation route has been developed to produce high-quality ultrathin phosphorene using simple means such as a high-speed shear mixer or even a household kitchen blender with the shear rate threshold of ˜1.25 × 104 s-1. The results reported here will pave the way for industrial-scale applications of rechargeable phosphorene LIBs.

  19. High Yield and Scalable Fabrication of Nano/Bio Hybrid Graphene Field Effect Transistors for Cancer Biomarker Detection

    NASA Astrophysics Data System (ADS)

    Ducos, Pedro; Diaz, Madeline; Robinson, Matthew; Johnson, A. T. Charlie

    2015-03-01

    Graphene field effect transistors (GFETs) hold tremendous promise for use as biosensor transduction elements due to graphene's high mobility, low noise and all-surface structure with every atom exposed to the environment. We developed a GFET array fabrication based on two approaches, pre-patterned transfer and post-transfer photolithography. Both approaches are scalable, high yield, and electrically stable. Functional groups for protein immobilization were added to the GFET using various bi-functional pyrene-based linkers. One approach immobilized an azide engineered protein through a ``Staudinger Reaction'' chemistry with NHS-phosphine reacting with a 1-aminopyrene linker. Another approach bound an engineered antibody via 1-pyrene butanoic acid succinimidyl ester, where an amine group of the antibody reacts to the succinimide of the linker. GFETs were studied by Raman spectroscopy, AFM and current-gate voltage (I-Vg) characterization at several steps of the fabrication process. A sensing response was obtained for a breast cancer biomarker (HER2) as a function of target concentration. We have started to design multiplexed sensor arrays by adding several functional groups to GFETs on a single chip. Simultaneous detection with these devices will be discussed.

  20. A new class of doped nanobulk high-figure-of-merit thermoelectrics by scalable bottom-up assembly.

    PubMed

    Mehta, Rutvik J; Zhang, Yanliang; Karthik, Chinnathambi; Singh, Binay; Siegel, Richard W; Borca-Tasciuc, Theodorian; Ramanath, Ganpati

    2012-01-10

    Obtaining thermoelectric materials with high figure of merit ZT is an exacting challenge because it requires the independent control of electrical conductivity, thermal conductivity and Seebeck coefficient, which are often unfavourably coupled. Recent works have devised strategies based on nanostructuring and alloying to address this challenge in thin films, and to obtain bulk p-type alloys with ZT>1. Here, we demonstrate a new class of both p- and n-type bulk nanomaterials with room-temperature ZT as high as 1.1 using a combination of sub-atomic-per-cent doping and nanostructuring. Our nanomaterials were fabricated by bottom-up assembly of sulphur-doped pnictogen chalcogenide nanoplates sculpted by a scalable microwave-stimulated wet-chemical method. Bulk nanomaterials from single-component assemblies or nanoplate mixtures of different materials exhibit 25-250% higher ZT than their non-nanostructured bulk counterparts and state-of-the-art alloys. Adapting our synthesis and assembly approach should enable nanobulk thermoelectrics with further increases in ZT for transforming thermoelectric refrigeration and power harvesting technologies.

  1. Scalable shear-exfoliation of high-quality phosphorene nanoflakes with reliable electrochemical cycleability in nano batteries

    DOE PAGES

    Xu, Feng; Ge, Binghui; Chen, Jing; ...

    2016-03-30

    Atomically thin black phosphorus (called phosphorene) holds great promise as an alternative to graphene and other two-dimensional transition-metal dichalcogenides as an anode material for lithium-ion batteries (LIBs). But, bulk black phosphorus (BP) suffers from rapid capacity fading and poor rechargeable performance. This work reports for the first time the use of in situ transmission electron microscopy (TEM) to construct nanoscale phosphorene LIBs. This enables direct visualization of the mechanisms underlying capacity fading in thick multilayer phosphorene through real-time capture of delithiation-induced structural decomposition, which serves to reduce electrical conductivity thus causing irreversibility of the lithiated phases. Furthermore, we demonstrate thatmore » few-layer-thick phosphorene successfully circumvents the structural decomposition and holds superior structural restorability, even when subject to multi-cycle lithiation/delithiation processes and concomitant huge volume expansion. This finding provides breakthrough insights into thickness-dependent lithium diffusion kinetics in phosphorene. More importantly, a scalable liquid-phase shear exfoliation route has been developed to produce high-quality ultrathin phosphorene using simple means such as a high-speed shear mixer or even a household kitchen blender with the shear rate threshold of ~1.25 × 104 s-1. Our results reported here will pave the way for industrial-scale applications of rechargeable phosphorene LIBs.« less

  2. Scalable shear-exfoliation of high-quality phosphorene nanoflakes with reliable electrochemical cycleability in nano batteries

    SciTech Connect

    Xu, Feng; Ge, Binghui; Chen, Jing; Nathan, Arokia; Xin, Linhuo L.; Ma, Hongyu; Zhu, Chongyang; Xia, Weiwei; Li, Zhengrui; Li, Shengli; Yu, Kaihao; Wu, Lijun; Cui, Yiping; Sun, Litao; Zhu, Yimei

    2016-03-30

    Atomically thin black phosphorus (called phosphorene) holds great promise as an alternative to graphene and other two-dimensional transition-metal dichalcogenides as an anode material for lithium-ion batteries (LIBs). But, bulk black phosphorus (BP) suffers from rapid capacity fading and poor rechargeable performance. This work reports for the first time the use of in situ transmission electron microscopy (TEM) to construct nanoscale phosphorene LIBs. This enables direct visualization of the mechanisms underlying capacity fading in thick multilayer phosphorene through real-time capture of delithiation-induced structural decomposition, which serves to reduce electrical conductivity thus causing irreversibility of the lithiated phases. Furthermore, we demonstrate that few-layer-thick phosphorene successfully circumvents the structural decomposition and holds superior structural restorability, even when subject to multi-cycle lithiation/delithiation processes and concomitant huge volume expansion. This finding provides breakthrough insights into thickness-dependent lithium diffusion kinetics in phosphorene. More importantly, a scalable liquid-phase shear exfoliation route has been developed to produce high-quality ultrathin phosphorene using simple means such as a high-speed shear mixer or even a household kitchen blender with the shear rate threshold of ~1.25 × 104 s-1. Our results reported here will pave the way for industrial-scale applications of rechargeable phosphorene LIBs.

  3. Scalable gene synthesis by selective amplification of DNA pools from high-fidelity microchips.

    PubMed

    Kosuri, Sriram; Eroshenko, Nikolai; Leproust, Emily M; Super, Michael; Way, Jeffrey; Li, Jin Billy; Church, George M

    2010-12-01

    Development of cheap, high-throughput and reliable gene synthesis methods will broadly stimulate progress in biology and biotechnology. Currently, the reliance on column-synthesized oligonucleotides as a source of DNA limits further cost reductions in gene synthesis. Oligonucleotides from DNA microchips can reduce costs by at least an order of magnitude, yet efforts to scale their use have been largely unsuccessful owing to the high error rates and complexity of the oligonucleotide mixtures. Here we use high-fidelity DNA microchips, selective oligonucleotide pool amplification, optimized gene assembly protocols and enzymatic error correction to develop a method for highly parallel gene synthesis. We tested our approach by assembling 47 genes, including 42 challenging therapeutic antibody sequences, encoding a total of ∼35 kilobase pairs of DNA. These assemblies were performed from a complex background containing 13,000 oligonucleotides encoding ∼2.5 megabases of DNA, which is at least 50 times larger than in previously published attempts.

  4. Scalable fabrication of high purity diamond nanocrystals with long-spin-coherence nitrogen vacancy centers.

    PubMed

    Trusheim, Matthew E; Li, Luozhou; Laraoui, Abdelghani; Chen, Edward H; Bakhru, Hassaram; Schröder, Tim; Gaathon, Ophir; Meriles, Carlos A; Englund, Dirk

    2014-01-08

    The combination of long spin coherence time and nanoscale size has made nitrogen vacancy (NV) centers in nanodiamonds the subject of much interest for quantum information and sensing applications. However, currently available high-pressure high-temperature (HPHT) nanodiamonds have a high concentration of paramagnetic impurities that limit their spin coherence time to the order of microseconds, less than 1% of that observed in bulk diamond. In this work, we use a porous metal mask and a reactive ion etching process to fabricate nanocrystals from high-purity chemical vapor deposition (CVD) diamond. We show that NV centers in these CVD nanodiamonds exhibit record-long spin coherence times in excess of 200 μs, enabling magnetic field sensitivities of 290 nT Hz(-1/2) with the spatial resolution characteristic of a 50 nm diameter probe.

  5. High-Speed Scalable Silicon-MoS2 P-N Heterojunction Photodetectors

    PubMed Central

    Dhyani, Veerendra; Das, Samaresh

    2017-01-01

    Two-dimensional molybdenum disulfide (MoS2) is a promising material for ultrasensitive photodetector owing to its favourable band gap and high absorption coefficient. However, their commercial applications are limited by the lack of high quality p-n junction and large wafer scale fabrication process. A high speed Si/MoS2 p-n heterojunction photodetector with simple and CMOS compatible approach has been reported here. The large area MoS2 thin film on silicon platform has been synthesized by sulfurization of RF-sputtered MoO3 films. The fabricated molecular layers of MoS2 on silicon offers high responsivity up to 8.75 A/W (at 580 nm and 3 V bias) with ultra-fast response of 10 μsec (rise time). Transient measurements of Si/MoS2 heterojunction under the modulated light reveal that the devices can function up to 50 kHz. The Si/MoS2 heterojunction is found to be sensitive to broadband wavelengths ranging from visible to near-infrared light with maximum detectivity up to ≈1.4 × 1012 Jones (2 V bias). Reproducible low dark current and high responsivity from over 20 devices in the same wafer has been measured. Additionally, the MoS2/Si photodetectors exhibit excellent stability in ambient atmosphere. PMID:28281652

  6. High-Speed Scalable Silicon-MoS2 P-N Heterojunction Photodetectors

    NASA Astrophysics Data System (ADS)

    Dhyani, Veerendra; Das, Samaresh

    2017-03-01

    Two-dimensional molybdenum disulfide (MoS2) is a promising material for ultrasensitive photodetector owing to its favourable band gap and high absorption coefficient. However, their commercial applications are limited by the lack of high quality p-n junction and large wafer scale fabrication process. A high speed Si/MoS2 p-n heterojunction photodetector with simple and CMOS compatible approach has been reported here. The large area MoS2 thin film on silicon platform has been synthesized by sulfurization of RF-sputtered MoO3 films. The fabricated molecular layers of MoS2 on silicon offers high responsivity up to 8.75 A/W (at 580 nm and 3 V bias) with ultra-fast response of 10 μsec (rise time). Transient measurements of Si/MoS2 heterojunction under the modulated light reveal that the devices can function up to 50 kHz. The Si/MoS2 heterojunction is found to be sensitive to broadband wavelengths ranging from visible to near-infrared light with maximum detectivity up to ≈1.4 × 1012 Jones (2 V bias). Reproducible low dark current and high responsivity from over 20 devices in the same wafer has been measured. Additionally, the MoS2/Si photodetectors exhibit excellent stability in ambient atmosphere.

  7. Multicatalytic colloids with highly scalable, adjustable, and stable functionalities in organic and aqueous media

    NASA Astrophysics Data System (ADS)

    Kim, Donghee; Cheong, Sanghyuk; Ahn, Yun Gyong; Ryu, Sook Won; Kim, Jai-Kyeong; Cho, Jinhan

    2016-03-01

    Despite a large number of developments of noble metal (or metal oxide) NP-based catalysts, it has been a great challenge to prepare high-performance recyclable catalysts with integrated functionalities that can be used in various solvent media. Here, we report on layer-by-layer (LbL) assembled multicatalysts with high catalytic performance, showing high dispersion and recycling stability in organic and aqueous media. The remarkable advantages of our approach are as follows. (i) Various metal or metal oxide NPs with desired catalytic performance can be easily incorporated into multilayered shells, forming densely packed arrays that allow one colloid to be used as a multicatalyst with highly integrated and controllable catalytic properties. (ii) Additionally, the dispersion stability of catalytic colloids in a desired solvent can be determined by the type of ultrathin outermost layer coating each colloid. (iii) Lastly, the covalent bonding between inorganic NPs and dendrimers within multilayer shells enhances the recycling stability of multicatalytic colloids. The resulting core-shell colloids including OA-Fe3O4 NPs, TOABr-Pd NPs, and OA-TiO2 NPs exhibited excellent performance in the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) and photocatalysis in aqueous media and in the Sonogashira coupling reaction (99% yield) in organic media. Given that the catalytic properties of recyclable colloids reported to date have entirely depended on the functionality of a single catalytic NP layer deposited onto colloids in selective solvent media, our approach provides a basis for the design and exploitation of high-performance recyclable colloids with integrated multicatalytic properties and high dispersion stability in a variety of solvents.Despite a large number of developments of noble metal (or metal oxide) NP-based catalysts, it has been a great challenge to prepare high-performance recyclable catalysts with integrated functionalities that can be used in various solvent

  8. Scalable preparation and characterization of GaN nanopowders with high crystallinity by soluble salts-assisted route

    NASA Astrophysics Data System (ADS)

    Lv, Yingying; Yu, Leshu; Ai, Wenwen; Li, Chungen

    2014-11-01

    By using Na3PO4 as a dispersant, soluble salt-assisted route has been further developed to prepare high-crystalline GaN nanoparticles powder on a large scale through the direct nitridation of Ga-Na3PO4 mixture at 750-950 °C and followed by washing with water. The systematical characterizations including XRD, Raman, IR, TEM, XPS, and PL spectrum showed that the as-prepared nanopowders were composed of nanoparticles in diameters of 8-18 nm, hexagonal phase, pure GaN, and had a broad UV centered at 388 nm and blue emissions band centered at around 547 nm. Because of the utilization of the simple reaction between metallic Ga and NH3, the preparation of pure GaN nanopowders becomes very easy, economical, and scalable, suggesting broad application in optoelectronic device material. The interesting results indicate the wide range of soluble salt-assisted route for promising industrial production of GaN nanopowders.

  9. A Scalable Gene Synthesis Platform Using High-Fidelity DNA Microchips

    PubMed Central

    Kosuri, Sriram; Eroshenko, Nikolai; LeProust, Emily; Super, Michael; Way, Jeffrey; Li, Jin Billy; Church, George M.

    2010-01-01

    Development of cheap, high-throughput, and reliable gene synthesis methods will broadly stimulate progress in biology and biotechnology1. Currently, the reliance on column-synthesized oligonucleotides as a source of DNA limits further cost reductions in gene synthesis2. Oligonucleotides from DNA microchips can reduce costs by at least an order of magnitude3,4,5, yet efforts to scale their use have been largely unsuccessful due to the high error rates and complexity of the oligonucleotide mixtures. Here we use high-fidelity DNA microchips, selective oligonucleotide pool amplification, optimized gene assembly protocols, and enzymatic error correction to develop a highly parallel gene synthesis platform. We tested our platform by assembling 47 genes, including 42 challenging therapeutic antibody sequences, encoding a total of ~35 kilo-basepairs of DNA. These assemblies were performed from a complex background containing 13,000 oligonucleotides encoding ~2.5 megabases of DNA, which is at least 50 times larger than previously published attempts. PMID:21113165

  10. Scalable fabrication of high-performance and flexible graphene strain sensors

    NASA Astrophysics Data System (ADS)

    Tian, He; Shu, Yi; Cui, Ya-Long; Mi, Wen-Tian; Yang, Yi; Xie, Dan; Ren, Tian-Ling

    2013-12-01

    Graphene strain sensors have promising prospects of applications in detecting human motion. However, the shortage of graphene growth and patterning techniques has become a challenging issue hindering the application of graphene strain sensors. Therefore, we propose wafer-scale flexible strain sensors with high-performance, which can be fabricated in one-step laser scribing. The graphene films could be obtained by directly reducing graphene oxide film in a Light-Scribe DVD burner. The gauge factor (GF) of the graphene strain sensor (10 mm × 10 mm square) is 0.11. In order to enhance the GF further, graphene micro-ribbons (20 μm width, 0.6 mm long) has been used as strain sensors, of which the GF is up to 9.49. The devices may conform to various application requirements, such as high GF for low-strain applications and low GF for high deformation applications. The work indicates that laser scribed flexible graphene strain sensors could be widely used in medical-sensing, bio-sensing, artificial skin and many other areas.Graphene strain sensors have promising prospects of applications in detecting human motion. However, the shortage of graphene growth and patterning techniques has become a challenging issue hindering the application of graphene strain sensors. Therefore, we propose wafer-scale flexible strain sensors with high-performance, which can be fabricated in one-step laser scribing. The graphene films could be obtained by directly reducing graphene oxide film in a Light-Scribe DVD burner. The gauge factor (GF) of the graphene strain sensor (10 mm × 10 mm square) is 0.11. In order to enhance the GF further, graphene micro-ribbons (20 μm width, 0.6 mm long) has been used as strain sensors, of which the GF is up to 9.49. The devices may conform to various application requirements, such as high GF for low-strain applications and low GF for high deformation applications. The work indicates that laser scribed flexible graphene strain sensors could be widely used

  11. Scalable synthesis of Fe₃O₄ nanoparticles anchored on graphene as a high-performance anode for lithium ion batteries

    SciTech Connect

    Dong, Yu Cheng; Ma, Ru Guang; Jun Hu, Ming; Cheng, Hua; Tsang, Chun Kwan; Yang, Qing Dan; Yang Li, Yang; Zapien, Juan Antonio

    2013-05-01

    We report a scalable strategy to synthesize Fe₃O₄/graphene nanocomposites as a high-performance anode material for lithium ion batteries. In this study, ferric citrate is used as precursor to prepare Fe₃O₄ nanoparticles without introducing additional reducing agent; furthermore and show that such Fe₃O₄ nanoparticles can be anchored on graphene sheets which attributed to multifunctional group effect of citrate. Electrochemical characterization of the Fe₃O₄/graphene nanocomposites exhibit large reversible capacity (~1347 mA h g⁻¹ at a current density of 0.2 C up to 100 cycles, and subsequent capacity of ~619 mA h g⁻¹ at a current density of 2 C up to 200 cycles), as well as high coulombic efficiency (~97%), excellent rate capability, and good cyclic stability. High resolution transmission electron microscopy confirms that Fe₃O₄ nanoparticles, with a size of ~4–16 nm are densely anchored on thin graphene sheets, resulting in large synergetic effects between Fe₃O₄ nanoparticles and graphene sheets with high electrochemical performance. - Graphical abstract: The reduction of Fe³⁺ to Fe²⁺ and the deposition of Fe₃O₄ on graphene sheets occur simultaneously using citrate function as reductant and anchor agent in this reaction process. Highlights: • Fe₃O₄/graphene composites are synthesized directly from graphene and C₆H₅FeO₇. • The citrate function as reductant and anchor agent in this reaction process. • The resulting Fe₃O₄ particles (~4–16 nm) are densely anchored on graphene sheets. • The prepared Fe₃O₄/graphene composites exhibit excellent electrochemical performance.

  12. Scalable Computational Methods for the Analysis of High-Throughput Biological Data

    SciTech Connect

    Langston, Michael A

    2012-09-06

    This primary focus of this research project is elucidating genetic regulatory mechanisms that control an organism's responses to low-dose ionizing radiation. Although low doses (at most ten centigrays) are not lethal to humans, they elicit a highly complex physiological response, with the ultimate outcome in terms of risk to human health unknown. The tools of molecular biology and computational science will be harnessed to study coordinated changes in gene expression that orchestrate the mechanisms a cell uses to manage the radiation stimulus. High performance implementations of novel algorithms that exploit the principles of fixed-parameter tractability will be used to extract gene sets suggestive of co-regulation. Genomic mining will be performed to scrutinize, winnow and highlight the most promising gene sets for more detailed investigation. The overall goal is to increase our understanding of the health risks associated with exposures to low levels of radiation.

  13. Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

    PubMed Central

    Sievers, Fabian; Wilm, Andreas; Dineen, David; Gibson, Toby J; Karplus, Kevin; Li, Weizhong; Lopez, Rodrigo; McWilliam, Hamish; Remmert, Michael; Söding, Johannes; Thompson, Julie D; Higgins, Desmond G

    2011-01-01

    Multiple sequence alignments are fundamental to many sequence analysis methods. Most alignments are computed using the progressive alignment heuristic. These methods are starting to become a bottleneck in some analysis pipelines when faced with data sets of the size of many thousands of sequences. Some methods allow computation of larger data sets while sacrificing quality, and others produce high-quality alignments, but scale badly with the number of sequences. In this paper, we describe a new program called Clustal Omega, which can align virtually any number of protein sequences quickly and that delivers accurate alignments. The accuracy of the package on smaller test cases is similar to that of the high-quality aligners. On larger data sets, Clustal Omega outperforms other packages in terms of execution time and quality. Clustal Omega also has powerful features for adding sequences to and exploiting information in existing alignments, making use of the vast amount of precomputed information in public databases like Pfam. PMID:21988835

  14. Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega.

    PubMed

    Sievers, Fabian; Wilm, Andreas; Dineen, David; Gibson, Toby J; Karplus, Kevin; Li, Weizhong; Lopez, Rodrigo; McWilliam, Hamish; Remmert, Michael; Söding, Johannes; Thompson, Julie D; Higgins, Desmond G

    2011-10-11

    Multiple sequence alignments are fundamental to many sequence analysis methods. Most alignments are computed using the progressive alignment heuristic. These methods are starting to become a bottleneck in some analysis pipelines when faced with data sets of the size of many thousands of sequences. Some methods allow computation of larger data sets while sacrificing quality, and others produce high-quality alignments, but scale badly with the number of sequences. In this paper, we describe a new program called Clustal Omega, which can align virtually any number of protein sequences quickly and that delivers accurate alignments. The accuracy of the package on smaller test cases is similar to that of the high-quality aligners. On larger data sets, Clustal Omega outperforms other packages in terms of execution time and quality. Clustal Omega also has powerful features for adding sequences to and exploiting information in existing alignments, making use of the vast amount of precomputed information in public databases like Pfam.

  15. Lightweight, flexible, high-performance carbon nanotube cables made by scalable flow coating

    DOE PAGES

    Mirri, Francesca; Orloff, Nathan D.; Forser, Aaron M.; ...

    2016-01-21

    Coaxial cables for data transmission are ubiquitous in telecommunications, aerospace, automotive, and robotics industries. Yet, the metals used to make commercial cables are unsuitably heavy and stiff. These undesirable traits are particularly problematic in aerospace applications, where weight is at a premium and flexibility is necessary to conform with the distributed layout of electronic components in satellites and aircraft. The cable outer conductor (OC) is usually the heaviest component of modern data cables; therefore, exchanging the conventional metallic OC for lower weight materials with comparable transmission characteristics is highly desirable. Carbon nanotubes (CNTs) have recently been proposed to replace themore » metal components in coaxial cables; however, signal attenuation was too high in prototypes produced so far. Here, we fabricate the OC of coaxial data cables by directly coating a solution of CNTs in chlorosulfonic acid (CSA) onto the cable inner dielectric. This coating has an electrical conductivity that is approximately 2 orders of magnitude greater than the best CNT OC reported in the literature to date. In conclusion, this high conductivity makes CNT coaxial cables an attractive alternative to commercial cables with a metal (tin-coated copper) OC, providing comparable cable attenuation and mechanical durability with a 97% lower component mass.« less

  16. Lightweight, flexible, high-performance carbon nanotube cables made by scalable flow coating

    SciTech Connect

    Mirri, Francesca; Orloff, Nathan D.; Forser, Aaron M.; Ashkar, Rana; Headrick, Robert J.; Bengio, E. Amram; Long, Christian J.; Choi, April; Luo, Yimin; Hight Walker, Angela R.; Butler, Paul; Migler, Kalman B.; Pasquali, Matteo

    2016-01-21

    Coaxial cables for data transmission are ubiquitous in telecommunications, aerospace, automotive, and robotics industries. Yet, the metals used to make commercial cables are unsuitably heavy and stiff. These undesirable traits are particularly problematic in aerospace applications, where weight is at a premium and flexibility is necessary to conform with the distributed layout of electronic components in satellites and aircraft. The cable outer conductor (OC) is usually the heaviest component of modern data cables; therefore, exchanging the conventional metallic OC for lower weight materials with comparable transmission characteristics is highly desirable. Carbon nanotubes (CNTs) have recently been proposed to replace the metal components in coaxial cables; however, signal attenuation was too high in prototypes produced so far. Here, we fabricate the OC of coaxial data cables by directly coating a solution of CNTs in chlorosulfonic acid (CSA) onto the cable inner dielectric. This coating has an electrical conductivity that is approximately 2 orders of magnitude greater than the best CNT OC reported in the literature to date. In conclusion, this high conductivity makes CNT coaxial cables an attractive alternative to commercial cables with a metal (tin-coated copper) OC, providing comparable cable attenuation and mechanical durability with a 97% lower component mass.

  17. Generation of Scalable, Metallic High-Aspect Ratio Nanocomposites in a Biological Liquid Medium.

    PubMed

    Cotton Kelly, Kinsey; Wasserman, Jessica R; Deodhar, Sneha; Huckaby, Justin; DeCoster, Mark A

    2015-07-08

    The goal of this protocol is to describe the synthesis of two novel biocomposites with high-aspect ratio structures. The biocomposites consist of copper and cystine, with either copper nanoparticles (CNPs) or copper sulfate contributing the metallic component. Synthesis is carried out in liquid under biological conditions (37 °C) and the self-assembled composites form after 24 hr. Once formed, these composites are highly stable in both liquid media and in a dried form. The composites scale from the nano- to micro- range in length, and from a few microns to 25 nm in diameter. Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (EDX) demonstrated that sulfur was present in the NP-derived linear structures, while it was absent from the starting CNP material, thus confirming cystine as the source of sulfur in the final nanocomposites. During synthesis of these linear nano- and micro-composites, a diverse range of lengths of structures is formed in the synthesis vessel. Sonication of the liquid mixture after synthesis was demonstrated to assist in controlling average size of the structures by diminishing the average length with increased time of sonication. Since the formed structures are highly stable, do not agglomerate, and are formed in liquid phase, centrifugation may also be used to assist in concentrating and segregating formed composites.

  18. Lightweight, Flexible, High-Performance Carbon Nanotube Cables Made by Scalable Flow Coating.

    PubMed

    Mirri, Francesca; Orloff, Nathan D; Forster, Aaron M; Ashkar, Rana; Headrick, Robert J; Bengio, E Amram; Long, Christian J; Choi, April; Luo, Yimin; Walker, Angela R Hight; Butler, Paul; Migler, Kalman B; Pasquali, Matteo

    2016-02-01

    Coaxial cables for data transmission are ubiquitous in telecommunications, aerospace, automotive, and robotics industries. Yet, the metals used to make commercial cables are unsuitably heavy and stiff. These undesirable traits are particularly problematic in aerospace applications, where weight is at a premium and flexibility is necessary to conform with the distributed layout of electronic components in satellites and aircraft. The cable outer conductor (OC) is usually the heaviest component of modern data cables; therefore, exchanging the conventional metallic OC for lower weight materials with comparable transmission characteristics is highly desirable. Carbon nanotubes (CNTs) have recently been proposed to replace the metal components in coaxial cables; however, signal attenuation was too high in prototypes produced so far. Here, we fabricate the OC of coaxial data cables by directly coating a solution of CNTs in chlorosulfonic acid (CSA) onto the cable inner dielectric. This coating has an electrical conductivity that is approximately 2 orders of magnitude greater than the best CNT OC reported in the literature to date. This high conductivity makes CNT coaxial cables an attractive alternative to commercial cables with a metal (tin-coated copper) OC, providing comparable cable attenuation and mechanical durability with a 97% lower component mass.

  19. Scalable synthesis of silicon-nanolayer-embedded graphite for high-energy lithium-ion batteries

    NASA Astrophysics Data System (ADS)

    Ko, Minseong; Chae, Sujong; Ma, Jiyoung; Kim, Namhyung; Lee, Hyun-Wook; Cui, Yi; Cho, Jaephil

    2016-09-01

    Existing anode technologies are approaching their limits, and silicon is recognized as a potential alternative due to its high specific capacity and abundance. However, to date the commercial use of silicon has not satisfied electrode calendering with limited binder content comparable to commercial graphite anodes for high energy density. Here we demonstrate the feasibility of a next-generation hybrid anode using silicon-nanolayer-embedded graphite/carbon. This architecture allows compatibility between silicon and natural graphite and addresses the issues of severe side reactions caused by structural failure of crumbled graphite dust and uncombined residue of silicon particles by conventional mechanical milling. This structure shows a high first-cycle Coulombic efficiency (92%) and a rapid increase of the Coulombic efficiency to 99.5% after only 6 cycles with a capacity retention of 96% after 100 cycles, with an industrial electrode density of >1.6 g cm-3, areal capacity loading of >3.3 mAh cm-2, and <4 wt% binding materials in a slurry. As a result, a full cell using LiCoO2 has demonstrated a higher energy density (1,043 Wh l-1) than with standard commercial graphite electrodes.

  20. Organic Radical-Assisted Electrochemical Exfoliation for the Scalable Production of High-Quality Graphene.

    PubMed

    Yang, Sheng; Brüller, Sebastian; Wu, Zhong-Shuai; Liu, Zhaoyang; Parvez, Khaled; Dong, Renhao; Richard, Fanny; Samorì, Paolo; Feng, Xinliang; Müllen, Klaus

    2015-11-04

    Despite the intensive research efforts devoted to graphene fabrication over the past decade, the production of high-quality graphene on a large scale, at an affordable cost, and in a reproducible manner still represents a great challenge. Here, we report a novel method based on the controlled electrochemical exfoliation of graphite in aqueous ammonium sulfate electrolyte to produce graphene in large quantities and with outstanding quality. Because the radicals (e.g., HO(•)) generated from water electrolysis are responsible for defect formation on graphene during electrochemical exfoliation, a series of reducing agents as additives (e.g., (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO), ascorbic acid, and sodium borohydride) have been investigated to eliminate these radicals and thus control the exfoliation process. Remarkably, TEMPO-assisted exfoliation results in large graphene sheets (5-10 μm on average), which exhibit outstanding hole mobilities (∼405 cm(2) V(-1) s(-1)), very low Raman I(D)/I(G) ratios (below 0.1), and extremely high carbon to oxygen (C/O) ratios (∼25.3). Moreover, the graphene ink prepared in dimethylformamide can exhibit concentrations as high as 6 mg mL(-1), thus qualifying this material for intriguing applications such as transparent conductive films and flexible supercapacitors. In general, this robust method for electrochemical exfoliation of graphite offers great promise for the preparation of graphene that can be utilized in industrial applications to create integrated nanocomposites, conductive or mechanical additives, as well as energy storage and conversion devices.

  1. Adaptive, High-Order, and Scalable Software Elements for Dynamic Rupture Simulations in Complex Geometries

    NASA Astrophysics Data System (ADS)

    Kozdon, J. E.; Wilcox, L.; Aranda, A. R.

    2014-12-01

    The goal of this work is to develop a new set of simulation tools for earthquake rupture dynamics based on state-of-the-art high-order, adaptive numerical methods capable of handling complex geometries. High-order methods are ideal for earthquake rupture simulations as the problems are wave-dominated and the waves excited in simulations propagate over distance much larger than their fundamental wavelength. When high-order methods are used for such problems significantly fewer degrees of freedom are required as compared with low-order methods. The base numerical method in our new software elements is a discontinuous Galerkin method based on curved, Kronecker product hexahedral elements. We currently use MPI for off-node parallelism and are in the process of exploring strategies for on-node parallelism. Spatial mesh adaptivity is handled using the p4est library and temporal adaptivity is achieved through an Adams-Bashforth based local time stepping method; we are presently in the process of including dynamic spatial adaptivity which we believe will be valuable for capturing the small-scale features around the propagating rupture front. One of the key features of our software elements is that the method is provably stable, even after the inclusion of the nonlinear frictions laws which govern rupture dynamics. In this presentation we will both outline the structure of the software elements as well as validate the rupture dynamics with SCEC benchmark test problems. We are also presently developing several realistic simulation geometries which may also be reported on. Finally, the software elements that we have designed are fully public domain and have been designed with tightly coupled, wave dominated multiphysics applications in mind. This latter design decisions means the software elements are applicable to many other geophysical and non-geophysical applications.

  2. Complexity in scalable computing.

    SciTech Connect

    Rouson, Damian W. I.

    2008-12-01

    The rich history of scalable computing research owes much to a rapid rise in computing platform scale in terms of size and speed. As platforms evolve, so must algorithms and the software expressions of those algorithms. Unbridled growth in scale inevitably leads to complexity. This special issue grapples with two facets of this complexity: scalable execution and scalable development. The former results from efficient programming of novel hardware with increasing numbers of processing units (e.g., cores, processors, threads or processes). The latter results from efficient development of robust, flexible software with increasing numbers of programming units (e.g., procedures, classes, components or developers). The progression in the above two parenthetical lists goes from the lowest levels of abstraction (hardware) to the highest (people). This issue's theme encompasses this entire spectrum. The lead author of each article resides in the Scalable Computing Research and Development Department at Sandia National Laboratories in Livermore, CA. Their co-authors hail from other parts of Sandia, other national laboratories and academia. Their research sponsors include several programs within the Department of Energy's Office of Advanced Scientific Computing Research and its National Nuclear Security Administration, along with Sandia's Laboratory Directed Research and Development program and the Office of Naval Research. The breadth of interests of these authors and their customers reflects in the breadth of applications this issue covers. This article demonstrates how to obtain scalable execution on the increasingly dominant high-performance computing platform: a Linux cluster with multicore chips. The authors describe how deep memory hierarchies necessitate reducing communication overhead by using threads to exploit shared register and cache memory. On a matrix-matrix multiplication problem, they achieve up to 96% parallel efficiency with a three-part strategy: intra

  3. Rapid, scalable and highly automated HLA genotyping using next-generation sequencing: a transition from research to diagnostics

    PubMed Central

    2013-01-01

    Background Human leukocyte antigen matching at allelic resolution is proven clinically significant in hematopoietic stem cell transplantation, lowering the risk of graft-versus-host disease and mortality. However, due to the ever growing HLA allele database, tissue typing laboratories face substantial challenges. In light of the complexity and the high degree of allelic diversity, it has become increasingly difficult to define the classical transplantation antigens at high-resolution by using well-tried methods. Thus, next-generation sequencing is entering into diagnostic laboratories at the perfect time and serving as a promising tool to overcome intrinsic HLA typing problems. Therefore, we have developed and validated a scalable automated HLA class I and class II typing approach suitable for diagnostic use. Results A validation panel of 173 clinical and proficiency testing samples was analysed, demonstrating 100% concordance to the reference method. From a total of 1,273 loci we were able to generate 1,241 (97.3%) initial successful typings. The mean ambiguity reduction for the analysed loci was 93.5%. Allele assignment including intronic sequences showed an improved resolution (99.2%) of non-expressed HLA alleles. Conclusion We provide a powerful HLA typing protocol offering a short turnaround time of only two days, a fully integrated workflow and most importantly a high degree of typing reliability. The presented automated assay is flexible and can be scaled by specific primer compilations and the use of different 454 sequencing systems. The workflow was successfully validated according to the policies of the European Federation for Immunogenetics. Next-generation sequencing seems to become one of the new methods in the field of Histocompatibility. PMID:23557197

  4. Scalable, high-capacity optical switches for Internet routers and moving platforms

    NASA Astrophysics Data System (ADS)

    Joe, In-Sung

    Internet traffic nearly doubles every year, and we need faster routers with higher ports count, yet lower electrical power consumption. Current internet routers use electrical switches that consume large amounts of electrical power to operate at high data rates. These internet routers dissipate ˜ 10kW per rack, and their capacity is limited by cooling constraints. The power consumption is also critical for moving platforms. As avionics advance, the demand for larger capacity networks increases. Optical fibers are already chosen for high speed data transmission in advanced aircraft. In optical communication systems, integrated passive optical components, such as Array Waveguide Gratings (AWGs), have provided larger capacity with lower power consumption, because minimal electrical power is required for their operation. In addition, compact, wavelength-tunable semiconductor lasers with wide tuning ranges that can switch their wavelengths in tens of nanoseconds have been demonstrated. Here we present a wavelength-selective optical packet switch based on Waveguide Grating Routers (WGRs), passive splitters, and combiners. Tunable lasers on the transmitter side are the only active switching elements. The WGR is operated on multiple Free Spectral Ranges (FSRs) to achieve increased port count and switching capacity while maintaining strict-sense, non-blocking operation. Switching times of less than 24ns between two wavelengths covering three FSRs is demonstrated experimentally. The electrical power consumption, size, weight, and cost of our optical switch is compared with those of conventional electrical switches, showing substantial improvements at large throughputs (˜2 Tb/s full duplex). A revised switch design that does not suffer optical loss from star couplers is proposed. This switch design uses only WGRs, and it is suitable for networks with stringent power budgets. The burst nature of the optical packet transmission requires clock recovery for every incoming

  5. High-throughput miniaturized bioreactors for cell culture process development: reproducibility, scalability, and control.

    PubMed

    Rameez, Shahid; Mostafa, Sigma S; Miller, Christopher; Shukla, Abhinav A

    2014-01-01

    Decreasing the timeframe for cell culture process development has been a key goal toward accelerating biopharmaceutical development. Advanced Microscale Bioreactors (ambr™) is an automated micro-bioreactor system with miniature single-use bioreactors with a 10-15 mL working volume controlled by an automated workstation. This system was compared to conventional bioreactor systems in terms of its performance for the production of a monoclonal antibody in a recombinant Chinese Hamster Ovary cell line. The miniaturized bioreactor system was found to produce cell culture profiles that matched across scales to 3 L, 15 L, and 200 L stirred tank bioreactors. The processes used in this article involve complex feed formulations, perturbations, and strict process control within the design space, which are in-line with processes used for commercial scale manufacturing of biopharmaceuticals. Changes to important process parameters in ambr™ resulted in predictable cell growth, viability and titer changes, which were in good agreement to data from the conventional larger scale bioreactors. ambr™ was found to successfully reproduce variations in temperature, dissolved oxygen (DO), and pH conditions similar to the larger bioreactor systems. Additionally, the miniature bioreactors were found to react well to perturbations in pH and DO through adjustments to the Proportional and Integral control loop. The data presented here demonstrates the utility of the ambr™ system as a high throughput system for cell culture process development.

  6. Highly Scalable, UDP-Based Network Transport Protocols for Lambda Grids and 10 GE Routed Networks

    SciTech Connect

    PI: Robert Grossman Co-PI: Stephen Eick

    2009-08-04

    Summary of Report In work prior to this grant, NCDM developed a high performance data transport protocol called SABUL. During this grant, we refined SABUL’s functionality, and then extended both the capabilities and functionality and incorporated them into a new protocol called UDP-based Data transport Protocol, or UDT. We also began preliminary work on Composable UDT, a version of UDT that allows the user to choose among different congestion control algorithms and implement the algorithm of his choice at the time he compiles the code. Specifically, we: · Investigated the theoretical foundations of protocols similar to SABUL and UDT. · Performed design and development work of UDT, a protocol that uses UDP in both the data and control channels. · Began design and development work of Composable UDT, a protocol that supports the use of different congestion control algorithms by simply including the appropriate library when compiling the code. · Performed experimental studies using UDT and Composable UDT using real world applications such as the Sloan Digital Sky Survey (SDSS) astronomical data sets. · Released several versions of UDT and Composable, the most recent being v3.1.

  7. Experimental determination of TRIP-parameter K for mild- and high-strength low-alloy steels and a super martensitic filler material.

    PubMed

    Neubert, Sebastian; Pittner, Andreas; Rethmeier, Michael

    2016-01-01

    A combined experimental numerical approach is applied to determine the transformation induced plasticity (TRIP)-parameter K for different strength low-alloy steels of grade S355J2+N and S960QL as well as the super martensitic filler CN13-4-IG containing 13 wt% chromium and 4 wt% nickel. The thermo-physical analyses were conducted using a Gleeble (®) 3500 facility. The thermal histories of the specimens to be tested were extracted from corresponding simulations of a real gas metal arc weldment. In contrast to common TRIP-experiments which are based on complex specimens a simple flat specimen was utilized together with an engineering evaluation method. The evaluation method was validated with literature values for the TRIP-parameter. It could be shown that the proposed approach enables a correct description of the TRIP behavior.

  8. Investigating the Role of Biogeochemical Processes in the Northern High Latitudes on Global Climate Feedbacks Using an Efficient Scalable Earth System Model

    SciTech Connect

    Jain, Atul K.

    2016-09-14

    The overall objectives of this DOE funded project is to combine scientific and computational challenges in climate modeling by expanding our understanding of the biogeophysical-biogeochemical processes and their interactions in the northern high latitudes (NHLs) using an earth system modeling (ESM) approach, and by adopting an adaptive parallel runtime system in an ESM to achieve efficient and scalable climate simulations through improved load balancing algorithms.

  9. SFT: Scalable Fault Tolerance

    SciTech Connect

    Petrini, Fabrizio; Nieplocha, Jarek; Tipparaju, Vinod

    2006-04-15

    In this paper we will present a new technology that we are currently developing within the SFT: Scalable Fault Tolerance FastOS project which seeks to implement fault tolerance at the operating system level. Major design goals include dynamic reallocation of resources to allow continuing execution in the presence of hardware failures, very high scalability, high efficiency (low overhead), and transparency—requiring no changes to user applications. Our technology is based on a global coordination mechanism, that enforces transparent recovery lines in the system, and TICK, a lightweight, incremental checkpointing software architecture implemented as a Linux kernel module. TICK is completely user-transparent and does not require any changes to user code or system libraries; it is highly responsive: an interrupt, such as a timer interrupt, can trigger a checkpoint in as little as 2.5μs; and it supports incremental and full checkpoints with minimal overhead—less than 6% with full checkpointing to disk performed as frequently as once per minute.

  10. Anatomically accurate high resolution modeling of human whole heart electromechanics: A strongly scalable algebraic multigrid solver method for nonlinear deformation.

    PubMed

    Augustin, Christoph M; Neic, Aurel; Liebmann, Manfred; Prassl, Anton J; Niederer, Steven A; Haase, Gundolf; Plank, Gernot

    2016-01-15

    Electromechanical (EM) models of the heart have been used successfully to study fundamental mechanisms underlying a heart beat in health and disease. However, in all modeling studies reported so far numerous simplifications were made in terms of representing biophysical details of cellular function and its heterogeneity, gross anatomy and tissue microstructure, as well as the bidirectional coupling between electrophysiology (EP) and tissue distension. One limiting factor is the employed spatial discretization methods which are not sufficiently flexible to accommodate complex geometries or resolve heterogeneities, but, even more importantly, the limited efficiency of the prevailing solver techniques which are not sufficiently scalable to deal with the incurring increase in degrees of freedom (DOF) when modeling cardiac electromechanics at high spatio-temporal resolution. This study reports on the development of a novel methodology for solving the nonlinear equation of finite elasticity using human whole organ models of cardiac electromechanics, discretized at a high para-cellular resolution. Three patient-specific, anatomically accurate, whole heart EM models were reconstructed from magnetic resonance (MR) scans at resolutions of 220 μm, 440 μm and 880 μm, yielding meshes of approximately 184.6, 24.4 and 3.7 million tetrahedral elements and 95.9, 13.2 and 2.1 million displacement DOF, respectively. The same mesh was used for discretizing the governing equations of both electrophysiology (EP) and nonlinear elasticity. A novel algebraic multigrid (AMG) preconditioner for an iterative Krylov solver was developed to deal with the resulting computational load. The AMG preconditioner was designed under the primary objective of achieving favorable strong scaling characteristics for both setup and solution runtimes, as this is key for exploiting current high performance computing hardware. Benchmark results using the 220 μm, 440 μm and 880 μm meshes demonstrate

  11. Anatomically accurate high resolution modeling of human whole heart electromechanics: A strongly scalable algebraic multigrid solver method for nonlinear deformation

    PubMed Central

    Augustin, Christoph M.; Neic, Aurel; Liebmann, Manfred; Prassl, Anton J.; Niederer, Steven A.; Haase, Gundolf; Plank, Gernot

    2016-01-01

    Electromechanical (EM) models of the heart have been used successfully to study fundamental mechanisms underlying a heart beat in health and disease. However, in all modeling studies reported so far numerous simplifications were made in terms of representing biophysical details of cellular function and its heterogeneity, gross anatomy and tissue microstructure, as well as the bidirectional coupling between electrophysiology (EP) and tissue distension. One limiting factor is the employed spatial discretization methods which are not sufficiently flexible to accommodate complex geometries or resolve heterogeneities, but, even more importantly, the limited efficiency of the prevailing solver techniques which are not sufficiently scalable to deal with the incurring increase in degrees of freedom (DOF) when modeling cardiac electromechanics at high spatio-temporal resolution. This study reports on the development of a novel methodology for solving the nonlinear equation of finite elasticity using human whole organ models of cardiac electromechanics, discretized at a high para-cellular resolution. Three patient-specific, anatomically accurate, whole heart EM models were reconstructed from magnetic resonance (MR) scans at resolutions of 220 μm, 440 μm and 880 μm, yielding meshes of approximately 184.6, 24.4 and 3.7 million tetrahedral elements and 95.9, 13.2 and 2.1 million displacement DOF, respectively. The same mesh was used for discretizing the governing equations of both electrophysiology (EP) and nonlinear elasticity. A novel algebraic multigrid (AMG) preconditioner for an iterative Krylov solver was developed to deal with the resulting computational load. The AMG preconditioner was designed under the primary objective of achieving favorable strong scaling characteristics for both setup and solution runtimes, as this is key for exploiting current high performance computing hardware. Benchmark results using the 220 μm, 440 μm and 880 μm meshes demonstrate

  12. Anatomically accurate high resolution modeling of human whole heart electromechanics: A strongly scalable algebraic multigrid solver method for nonlinear deformation

    NASA Astrophysics Data System (ADS)

    Augustin, Christoph M.; Neic, Aurel; Liebmann, Manfred; Prassl, Anton J.; Niederer, Steven A.; Haase, Gundolf; Plank, Gernot

    2016-01-01

    Electromechanical (EM) models of the heart have been used successfully to study fundamental mechanisms underlying a heart beat in health and disease. However, in all modeling studies reported so far numerous simplifications were made in terms of representing biophysical details of cellular function and its heterogeneity, gross anatomy and tissue microstructure, as well as the bidirectional coupling between electrophysiology (EP) and tissue distension. One limiting factor is the employed spatial discretization methods which are not sufficiently flexible to accommodate complex geometries or resolve heterogeneities, but, even more importantly, the limited efficiency of the prevailing solver techniques which is not sufficiently scalable to deal with the incurring increase in degrees of freedom (DOF) when modeling cardiac electromechanics at high spatio-temporal resolution. This study reports on the development of a novel methodology for solving the nonlinear equation of finite elasticity using human whole organ models of cardiac electromechanics, discretized at a high para-cellular resolution. Three patient-specific, anatomically accurate, whole heart EM models were reconstructed from magnetic resonance (MR) scans at resolutions of 220 μm, 440 μm and 880 μm, yielding meshes of approximately 184.6, 24.4 and 3.7 million tetrahedral elements and 95.9, 13.2 and 2.1 million displacement DOF, respectively. The same mesh was used for discretizing the governing equations of both electrophysiology (EP) and nonlinear elasticity. A novel algebraic multigrid (AMG) preconditioner for an iterative Krylov solver was developed to deal with the resulting computational load. The AMG preconditioner was designed under the primary objective of achieving favorable strong scaling characteristics for both setup and solution runtimes, as this is key for exploiting current high performance computing hardware. Benchmark results using the 220 μm, 440 μm and 880 μm meshes demonstrate

  13. Highly scalable, uniform, and sensitive biosensors based on top-down indium oxide nanoribbons and electronic enzyme-linked immunosorbent assay.

    PubMed

    Aroonyadet, Noppadol; Wang, Xiaoli; Song, Yan; Chen, Haitian; Cote, Richard J; Thompson, Mark E; Datar, Ram H; Zhou, Chongwu

    2015-03-11

    Nanostructure field-effect transistor (FET) biosensors have shown great promise for ultra sensitive biomolecular detection. Top-down assembly of these sensors increases scalability and device uniformity but faces fabrication challenges in achieving the small dimensions needed for sensitivity. We report top-down fabricated indium oxide (In2O3) nanoribbon FET biosensors using highly scalable radio frequency (RF) sputtering to create uniform channel thicknesses ranging from 50 to 10 nm. We combine this scalable sensing platform with amplification from electronic enzyme-linked immunosorbent assay (ELISA) to achieve high sensitivity to target analytes such as streptavidin and human immunodeficiency virus type 1 (HIV-1) p24 proteins. Our approach circumvents Debye screening in ionic solutions and detects p24 protein at 20 fg/mL (about 250 viruses/mL or about 3 orders of magnitude lower than commercial ELISA) with a 35% conduction change in human serum. The In2O3 nanoribbon biosensors have 100% device yield and use a simple 2 mask photolithography process. The electrical properties of 50 In2O3 nanoribbon FETs showed good uniformity in on-state current, on/off current ratio, mobility, and threshold voltage. In addition, the sensors show excellent pH sensitivity over a broad range (pH 4 to 9) as well as over the physiological-related pH range (pH 6.8 to 8.2). With the demonstrated sensitivity, scalability, and uniformity, the In2O3 nanoribbon sensor platform makes great progress toward clinical testing, such as for early diagnosis of acquired immunodeficiency syndrome (AIDS).

  14. On the Merits of "Unusual Field Trips."

    ERIC Educational Resources Information Center

    Howarth, Dean E.

    1999-01-01

    Describes the organization and completion of a scientific field trip for a group of high school physics students that was organized primarily around a study of the Manhattan Project. The group visited the Trinity site, Los Alamos, several museums, and the National Radio Astronomy Observatory Very Large Array. Contact information for the various…

  15. 9 Tips for Affordable Student Trips

    ERIC Educational Resources Information Center

    Adams, Jonathan

    2013-01-01

    The trick to having a successful and affordable trip is planning ahead and planning thoroughly. Keep the spirits high and the costs low by following a well-traveled ensemble director's suggestions as presented in this article. These tips include finding local attractions that are unique to the city that the group will be visiting, looking at…

  16. The TRAF-interacting protein (TRIP) is a regulator of keratinocyte proliferation.

    PubMed

    Almeida, Stéphanie; Ryser, Stephan; Obarzanek-Fojt, Magdalena; Hohl, Daniel; Huber, Marcel

    2011-02-01

    The TRAF-interacting protein (TRIP/TRAIP) is a RING-type E3 ubiquitin ligase inhibiting tumor necrosis factor-α (TNF-α)-mediated NF-κB activation. TRIP ablation results in early embryonic lethality in mice. To investigate TRIP function in epidermis, we examined its expression and the effect of TRIP knockdown (KD) in keratinocytes. TRIP mRNA expression was strongly downregulated in primary human keratinocytes undergoing differentiation triggered by high cell density or high calcium. Short-term phorbol-12-myristate-13-acetate (TPA) treatment or inhibition of phosphatidylinositol-3 kinase signaling in proliferative keratinocytes suppressed TRIP transcription. Inhibition by TPA was protein kinase C dependent. Keratinocytes undergoing KD of TRIP expression by lentiviral short-hairpin RNA (shRNA; T4 and T5) had strongly reduced proliferation rates compared with control shRNA. Cell cycle analysis demonstrated that TRIP-KD caused growth arrest in the G1/S phase. Keratinocytes with TRIP-KD resembled differentiated cells consistent with the augmented expression of differentiation markers keratin 1 and filaggrin. Luciferase-based reporter assays showed no increase in NF-κB activity in TRIP-KD keratinocytes, indicating that NF-κB activity in keratinocytes is not regulated by TRIP. TRIP expression was increased by ∼2-fold in basal cell carcinomas compared with normal skin. These results underline the important role of TRIP in the regulation of cell cycle progression and the tight linkage of its expression to keratinocyte proliferation.

  17. Scalable and High-Throughput Execution of Clinical Quality Measures from Electronic Health Records using MapReduce and the JBoss® Drools Engine.

    PubMed

    Peterson, Kevin J; Pathak, Jyotishman

    2014-01-01

    Automated execution of electronic Clinical Quality Measures (eCQMs) from electronic health records (EHRs) on large patient populations remains a significant challenge, and the testability, interoperability, and scalability of measure execution are critical. The High Throughput Phenotyping (HTP; http://phenotypeportal.org) project aligns with these goals by using the standards-based HL7 Health Quality Measures Format (HQMF) and Quality Data Model (QDM) for measure specification, as well as Common Terminology Services 2 (CTS2) for semantic interpretation. The HQMF/QDM representation is automatically transformed into a JBoss(®) Drools workflow, enabling horizontal scalability via clustering and MapReduce algorithms. Using Project Cypress, automated verification metrics can then be produced. Our results show linear scalability for nine executed 2014 Center for Medicare and Medicaid Services (CMS) eCQMs for eligible professionals and hospitals for >1,000,000 patients, and verified execution correctness of 96.4% based on Project Cypress test data of 58 eCQMs.

  18. Application of the FETI Method to ASCI Problems: Scalability Results on One Thousand Processors and Discussion of Highly Heterogeneous Problems

    SciTech Connect

    Bhardwaj, M.; Day, D.; Farhat, C.; Lesoinne, M; Pierson, K.; Rixen, D.

    1999-04-01

    We report on the application of the one-level FETI method to the solution of a class of substructural problems associated with the Department of Energy's Accelerated Strategic Computing Initiative (ASCI). We focus on numerical and parallel scalability issues, and on preliminary performance results obtained on the ASCI Option Red supercomputer configured with as many as one thousand processors, for problems with as many as 5 million degrees of freedom.

  19. Field Trips Within Easy Reach.

    ERIC Educational Resources Information Center

    Fitzsimmons, Charles P.

    1983-01-01

    Provides suggestions for conducting field trips at the local school site. Points of interest might include building materials, evidence of chemical/physical weathering, variations in soil type, changes in elevation on school ground, and others. Three simple field trips are described. (JN)

  20. 8th Grade Canadian Trip.

    ERIC Educational Resources Information Center

    Jelinek, Gilbert; Schoenike, Paul

    Ideas are offered for helping eighth-grade students incorporate an at-home field trip to Canada into a social studies unit. The teachers who developed the unit state that students can complete the 21-day imaginary trip in five hours of classroom time when appropriate materials are available and the classroom environment is conducive to working on…

  1. Squishy Physics Field Trips

    NASA Astrophysics Data System (ADS)

    Weeks, Eric R.; Cianci, Gianguido; Habdas, Piotr

    2008-03-01

    Our laboratory studies soft condensed matter, which means we investigate squishy materials such as foams, emulsions, and colloidal suspensions. These materials include common things such as peanut butter, toothpaste, mayonnaise, shampoo, and shaving cream. We have conducted several field trips for grade school students, where they come to our laboratory and play with squishy materials. They do both hands-on table-top projects and also look at samples with a microscope. We have also developed some of these activities into labs appropriate for first-year college students. Our first goal for these activities is to show students that science is fun, and the second goal is to get them intrigued by the idea that there are more phases than just solids, liquids, and gases.

  2. Apollo 14 Road Trip

    NASA Astrophysics Data System (ADS)

    Valleli, P.

    2012-06-01

    (Abstract only) In January-February 1971, five astronomy enthusiasts, Dennis Milon, Alan Rowher, Sal LaRiccia, Mike Mattei, and Paul Valleli, drove from New Haven, Connecticut, to the Kennedy Space Center at Cape Canaveral, Florida. They joined with ALPO Jupiter Recorder Julius Benton in Atlanta. After several stops along the way, the six arrived at the Apollo 14 launch site to observe pre-launch activity, met NASA personnel, and toured various facilities. On launch day, thanks to press passes provided by Dennis Milon who was there as the official photojournalist for Sky & Telescope, they met the Apollo crew and witnessed the launch. On the return trip, they made time to meet Mike Mattei's new girlfriend, Janet Akyü;z, who was working on her Master's at Leander-McCormick Observatory in Charlottesville, Virginia. Janet gave the six men a tour of the observatory, including the the 26-inch Clark Telescope.

  3. Use of High-Power Brayton Nuclear Electric Propulsion (NEP) for a 2033 Mars Round-Trip Mission

    SciTech Connect

    McGuire, Melissa L.; Martini, Michael C.; Packard, Thomas W.; Weglian, John E.; Gilland, James H.

    2006-01-20

    The Revolutionary Aerospace Systems Concepts (RASC) team, led by the NASA Langley Research Center, is tasked with exploring revolutionary new approaches to enabling NASA to achieve its strategic goals and objectives in future missions. This paper provides the details from the 2004-2005 RASC study of a point-design that uses a high-power nuclear electric propulsion (NEP) based space transportation architecture to support a manned mission to Mars. The study assumes a high-temperature liquid-metal cooled fission reactor with a Brayton power conversion system to generate the electrical power required by magnetoplasmadynamic (MPD) thrusters. The architecture includes a cargo vehicle with an NEP system providing 5 MW of electrical power and a crewed vehicle with an NEP system with two reactors providing a combined total of 10 MW of electrical power. Both vehicles use a low-thrust, high-efficiency (5000 sec specific impulse) MPD system to conduct a spiral-out of the Earth gravity well, a low-thrust heliocentric trajectory, and a spiral-in at Mars with arrival late in 2033. The cargo vehicle carries two moon landers to Mars and arrives shortly before the crewed vehicle. The crewed vehicle and cargo vehicle rendezvous in Mars orbit and, over the course of the 60-day stay, the crew conducts nine-day excursions to Phobos and Deimos with the landers. The crewed vehicle then spirals out of Martian orbit and returns via a low-thrust trajectory to conduct an Earth flyby. The crew separates from the vehicle prior to Earth flyby and aerobrakes for a direct-entry landing.

  4. Use of High-Power Brayton Nuclear Electric Propulsion (NEP) for a 2033 Mars Round-Trip Mission

    NASA Astrophysics Data System (ADS)

    McGuire, Melissa L.; Martini, Michael C.; Packard, Thomas W.; Weglian, John E.; Gilland, James H.

    2006-01-01

    The Revolutionary Aerospace Systems Concepts (RASC) team, led by the NASA Langley Research Center, is tasked with exploring revolutionary new approaches to enabling NASA to achieve its strategic goals and objectives in future missions. This paper provides the details from the 2004-2005 RASC study of a point-design that uses a high-power nuclear electric propulsion (NEP) based space transportation architecture to support a manned mission to Mars. The study assumes a high-temperature liquid-metal cooled fission reactor with a Brayton power conversion system to generate the electrical power required by magnetoplasmadynamic (MPD) thrusters. The architecture includes a cargo vehicle with an NEP system providing 5 MW of electrical power and a crewed vehicle with an NEP system with two reactors providing a combined total of 10 MW of electrical power. Both vehicles use a low-thrust, high-efficiency (5000 sec specific impulse) MPD system to conduct a spiral-out of the Earth gravity well, a low-thrust heliocentric trajectory, and a spiral-in at Mars with arrival late in 2033. The cargo vehicle carries two moon landers to Mars and arrives shortly before the crewed vehicle. The crewed vehicle and cargo vehicle rendezvous in Mars orbit and, over the course of the 60-day stay, the crew conducts nine-day excursions to Phobos and Deimos with the landers. The crewed vehicle then spirals out of Martian orbit and returns via a low-thrust trajectory to conduct an Earth flyby. The crew separates from the vehicle prior to Earth flyby and aerobrakes for a direct-entry landing.

  5. Tick-Borne Relapsing Fever Outbreak Among a High School Football Team at an Outdoor Education Camping Trip, Arizona, 2014.

    PubMed

    Jones, Jefferson M; Hranac, Carter R; Schumacher, Mare; Horn, Kim; Lee, Darlene M; Terriquez, Joel; Engelthaler, David M; Peoples, Marie; Corrigan, Jennifer; Replogle, Adam; Souders, Nina; Komatsu, Kenneth K; Nieto, Nathan C

    2016-09-07

    During August 2014, five high school students who had attended an outdoor education camp were hospitalized with a febrile illness, prompting further investigation. Ten total cases of tick-borne relapsing fever (TBRF) were identified-six cases confirmed by culture or visualization of spirochetes on blood smear and four probable cases with compatible symptoms (attack rate: 23%). All patients had slept in the campsite's only cabin. Before the camp, a professional pest control company had rodent proofed the cabin, but no acaricides had been applied. Cabin inspection after the camp found rodents and Ornithodoros ticks, the vector of TBRF. Blood samples from a chipmunk trapped near the cabin and from patients contained Borrelia hermsii with identical gene sequences (100% over 630 base pairs). Health departments in TBRF endemic areas should consider educating cabin owners and pest control companies to apply acaricides during or following rodent proofing, because ticks that lack rodents for a blood meal might feed on humans.

  6. Highly nitrogen-doped carbon capsules: scalable preparation and high-performance applications in fuel cells and lithium ion batteries

    NASA Astrophysics Data System (ADS)

    Hu, Chuangang; Xiao, Ying; Zhao, Yang; Chen, Nan; Zhang, Zhipan; Cao, Minhua; Qu, Liangti

    2013-03-01

    Highly nitrogen-doped carbon capsules (hN-CCs) have been successfully prepared by using inexpensive melamine and glyoxal as precursors via solvothermal reaction and carbonization. With a great promise for large scale production, the hN-CCs, having large surface area and high-level nitrogen content (N/C atomic ration of ca. 13%), possess superior crossover resistance, selective activity and catalytic stability towards oxygen reduction reaction for fuel cells in alkaline medium. As a new anode material in lithium-ion battery, hN-CCs also exhibit excellent cycle performance and high rate capacity with a reversible capacity of as high as 1046 mA h g-1 at a current density of 50 mA g-1 after 50 cycles. These features make the hN-CCs developed in this study promising as suitable substitutes for the expensive noble metal catalysts in the next generation alkaline fuel cells, and as advanced electrode materials in lithium-ion batteries.Highly nitrogen-doped carbon capsules (hN-CCs) have been successfully prepared by using inexpensive melamine and glyoxal as precursors via solvothermal reaction and carbonization. With a great promise for large scale production, the hN-CCs, having large surface area and high-level nitrogen content (N/C atomic ration of ca. 13%), possess superior crossover resistance, selective activity and catalytic stability towards oxygen reduction reaction for fuel cells in alkaline medium. As a new anode material in lithium-ion battery, hN-CCs also exhibit excellent cycle performance and high rate capacity with a reversible capacity of as high as 1046 mA h g-1 at a current density of 50 mA g-1 after 50 cycles. These features make the hN-CCs developed in this study promising as suitable substitutes for the expensive noble metal catalysts in the next generation alkaline fuel cells, and as advanced electrode materials in lithium-ion batteries. Electronic supplementary information (ESI) available: More experimental details and characterization. See DOI: 10

  7. Highly nitrogen-doped carbon capsules: scalable preparation and high-performance applications in fuel cells and lithium ion batteries.

    PubMed

    Hu, Chuangang; Xiao, Ying; Zhao, Yang; Chen, Nan; Zhang, Zhipan; Cao, Minhua; Qu, Liangti

    2013-04-07

    Highly nitrogen-doped carbon capsules (hN-CCs) have been successfully prepared by using inexpensive melamine and glyoxal as precursors via solvothermal reaction and carbonization. With a great promise for large scale production, the hN-CCs, having large surface area and high-level nitrogen content (N/C atomic ration of ca. 13%), possess superior crossover resistance, selective activity and catalytic stability towards oxygen reduction reaction for fuel cells in alkaline medium. As a new anode material in lithium-ion battery, hN-CCs also exhibit excellent cycle performance and high rate capacity with a reversible capacity of as high as 1046 mA h g(-1) at a current density of 50 mA g(-1) after 50 cycles. These features make the hN-CCs developed in this study promising as suitable substitutes for the expensive noble metal catalysts in the next generation alkaline fuel cells, and as advanced electrode materials in lithium-ion batteries.

  8. Volume server: A scalable high speed and high capacity magnetic tape archive architecture with concurrent multi-host access

    NASA Technical Reports Server (NTRS)

    Rybczynski, Fred

    1993-01-01

    A major challenge facing data processing centers today is data management. This includes the storage of large volumes of data and access to it. Current media storage for large data volumes is typically off line and frequently off site in warehouses. Access to data archived in this fashion can be subject to long delays, errors in media selection and retrieval, and even loss of data through misplacement or damage to the media. Similarly, designers responsible for architecting systems capable of continuous high-speed recording of large volumes of digital data are faced with the challenge of identifying technologies and configurations that meet their requirements. Past approaches have tended to evaluate the combination of the fastest tape recorders with the highest capacity tape media and then to compromise technology selection as a consequence of cost. This paper discusses an architecture that addresses both of these challenges and proposes a cost effective solution based on robots, high speed helical scan tape drives, and large-capacity media.

  9. Mars rapid round trip mission design

    NASA Astrophysics Data System (ADS)

    Sarzi Amade', Nicola

    The present research is divided in two parts. The first part is a well defined mathematical problem, with exact rules and results, in which the basic constraints for interplanetary round trip travels are used to calculate an interplanetary train schedule (ITS) of missions to Mars, in the general case of orbits with non-zero eccentricity and non-zero inclination. Several possible options for round trip travels to Mars are considered. In particular, options at high energy, which allow rapid round trip missions, are discussed. These options have important applications for human travels to Mars. The second part of the research is about systems engineering aspects, which are intrinsically less exact, since they can change with time due, for example, to technology development or economic and political factors. For the case of a selected human rapid round trip mission to Mars, the development of a mission architecture, an assessment of the masses involved in the mission (such as the initial masses required in LEO), an estimate of the necessary number of launches, and a preliminary analysis of the radiation protection requirements, are performed. The main problem that justifies the existence of basic constraints for round trip missions is that by increasing the DeltaV of a mission, in general the total round trip time does not vary much, because a higher DeltaV can only reduce the transfer time and it simply increases the stay-time on the target planet. However, if the DeltaV is increased beyond a well-defined level, the total round trip time has a sudden drop in duration that makes fast round trips possible. This is due to the fact that the traveler can go back before the home planet makes one extra revolution around the Sun. For a sufficiently high DeltaV, a round trip to Mars can change in duration from 2.7 years to about 5 months. For Mars missions, the round trip times are calculated for different DeltaV's and for different transfer trajectories (T1, T2, etc.). An

  10. Advanced transportation concept for round-trip space travel

    NASA Technical Reports Server (NTRS)

    Yen, Chen-Wan L.

    1988-01-01

    A departure from the conventional concept of round-trip space travel is introduced. It is shown that a substantial reduction in the initial load required of the Shuttle or other launch vehicle can be achieved by staging the ascent orbit and leaving fuel for the return trip at each stage of the orbit. Examples of round trips from a low-inclination LEO to a high-inclination LEO and from an LEO to a GEO are used to show the merits of the new concept. Potential problem areas and research needed for the development of an efficient space transportation network are discussed.

  11. Highly Efficient High-Pressure Homogenization Approach for Scalable Production of High-Quality Graphene Sheets and Sandwich-Structured α-Fe2O3/Graphene Hybrids for High-Performance Lithium-Ion Batteries.

    PubMed

    Qi, Xin; Zhang, Hao-Bin; Xu, Jiantie; Wu, Xinyu; Yang, Dongzhi; Qu, Jin; Yu, Zhong-Zhen

    2017-03-29

    A highly efficient and continuous high-pressure homogenization (HPH) approach is developed for scalable production of graphene sheets and sandwich-structured α-Fe2O3/graphene hybrids by liquid-phase exfoliation of stage-1 FeCl3-based graphite intercalation compounds (GICs). The enlarged interlayer spacing of FeCl3-GICs facilitates their efficient exfoliation to produce high-quality graphene sheets. Moreover, sandwich-structured α-Fe2O3/few-layer graphene (FLG) hybrids are readily fabricated by thermally annealing the FeCl3 intercalated FLG sheets. As an anode material of Li-ion battery, α-Fe2O3/FLG hybrid shows a satisfactory long-term cycling performance with an excellent specific capacity of 1100.5 mA h g(-1) after 350 cycles at 200 mA g(-1). A high reversible capacity of 658.5 mA h g(-1) is achieved after 200 cycles at 1 A g(-1) and maintained without notable decay. The satisfactory cycling stability and the outstanding capability of α-Fe2O3/FLG hybrid are attributed to its unique sandwiched structure consisting of highly conducting FLG sheets and covalently anchored α-Fe2O3 particles. Therefore, the highly efficient and scalable preparation of high-quality graphene sheets along with the excellent electrochemical properties of α-Fe2O3/FLG hybrids makes the HPH approach promising for producing high-performance graphene-based energy storage materials.

  12. The use of dendrimers as high-performance shells for round-trip energy transfer: efficient trans-cis photoisomerization from an excited triplet state produced within a dendrimer shell.

    PubMed

    Miura, Yousuke; Momotake, Atsuya; Takeuchi, Keiichirou; Arai, Tatsuo

    2011-01-01

    A series of stilbene-cored poly(benzyl ether) dendrimers with benzophenone peripheries were synthesized and their photophysical and photochemical properties were studied. Fluorescence studies revealed that singlet-singlet energy transfer (SSET) from the stilbene core to the benzophenone units took place efficiently in dendrimers of all generations. Similarly, phosphorescence and time-resolved spectroscopic measurements indicated efficient triplet-triplet energy transfer (TTET) from the benzophenone periphery to the stilbene core. Upon excitation at 310 nm, the stilbene core isomerizes via an energy round trip within the dendrimer shell. The quantum yields for the energy round trip (Φ(ERT)), defined as the product of the quantum yields of SSET, intersystem crossing, and TTET (Φ(ERT) = Φ(SS)Φ(isc)Φ(TT)), were extremely high for all generations--99%, 95% and 94% for G1, G2, and G3, respectively--which means that the excitation energy of the dendrimer core was transferred to the dendrimer periphery and back to the core almost quantitatively. The quantum yield for photoisomerization of G1-G3 via an energy round trip was higher than for other stilbene-cored dendrimers, which mainly isomerize from the excited singlet state. Photostability in the dendrimers was also demonstrated and discussed.

  13. OneBac: Platform for Scalable and High-Titer Production of Adeno-Associated Virus Serotype 1–12 Vectors for Gene Therapy

    PubMed Central

    Mietzsch, Mario; Grasse, Sabrina; Zurawski, Catherine; Weger, Stefan; Bennett, Antonette; Agbandje-McKenna, Mavis; Muzyczka, Nicholas; Zolotukhin, Sergei

    2014-01-01

    Abstract Scalable and genetically stable recombinant adeno-associated virus (rAAV) production systems combined with facile adaptability for an extended repertoire of AAV serotypes are required to keep pace with the rapidly increasing clinical demand. For scalable high-titer production of the full range of rAAV serotypes 1–12, we developed OneBac, consisting of stable insect Sf9 cell lines harboring silent copies of AAV1–12 rep and cap genes induced upon infection with a single baculovirus that also carries the rAAV genome. rAAV burst sizes reach up to 5×105 benzonase-resistant, highly infectious genomic particles per cell, exceeding typical yields of current rAAV production systems. In contrast to recombinant rep/cap baculovirus strains currently employed for large-scale rAAV production, the Sf9rep/cap cell lines are genetically stable, leading to undiminished rAAV burst sizes over serial passages. Thus, OneBac combines full AAV serotype options with the capacity for stable scale-up production, the current bottleneck for the transition of AAV from gene therapy trials to routine clinical treatment. PMID:24299301

  14. Scalable Synthesis of Few-Layer MoS2 Incorporated into Hierarchical Porous Carbon Nanosheets for High-Performance Li- and Na-Ion Battery Anodes.

    PubMed

    Park, Seung-Keun; Lee, Jeongyeon; Bong, Sungyool; Jang, Byungchul; Seong, Kwang-Dong; Piao, Yuanzhe

    2016-08-03

    It is still a challenging task to develop a facile and scalable process to synthesize porous hybrid materials with high electrochemical performance. Herein, a scalable strategy is developed for the synthesis of few-layer MoS2 incorporated into hierarchical porous carbon (MHPC) nanosheet composites as anode materials for both Li- (LIB) and Na-ion battery (SIB). An inexpensive oleylamine (OA) is introduced to not only serve as a hinder the stacking of MoS2 nanosheets but also to provide a conductive carbon, allowing large scale production. In addition, a SiO2 template is adopted to direct the growth of both carbon and MoS2 nanosheets, resulting in the formation of hierarchical porous structures with interconnected networks. Due to these unique features, the as-obtained MHPC shows substantial reversible capacity and very long cycling performance when used as an anode material for LIBs and SIBs, even at high current density. Indeed, this material delivers reversible capacities of 732 and 280 mA h g(-1) after 300 cycles at 1 A g(-1) in LIBs and SIBs, respectively. The results suggest that these MHPC composites also have tremendous potential for applications in other fields.

  15. Scalable synthesis of interconnected porous silicon/carbon composites by the Rochow reaction as high-performance anodes of lithium ion batteries.

    PubMed

    Zhang, Zailei; Wang, Yanhong; Ren, Wenfeng; Tan, Qiangqiang; Chen, Yunfa; Li, Hong; Zhong, Ziyi; Su, Fabing

    2014-05-12

    Despite the promising application of porous Si-based anodes in future Li ion batteries, the large-scale synthesis of these materials is still a great challenge. A scalable synthesis of porous Si materials is presented by the Rochow reaction, which is commonly used to produce organosilane monomers for synthesizing organosilane products in chemical industry. Commercial Si microparticles reacted with gas CH3 Cl over various Cu-based catalyst particles to substantially create macropores within the unreacted Si accompanying with carbon deposition to generate porous Si/C composites. Taking advantage of the interconnected porous structure and conductive carbon-coated layer after simple post treatment, these composites as anodes exhibit high reversible capacity and long cycle life. It is expected that by integrating the organosilane synthesis process and controlling reaction conditions, the manufacture of porous Si-based anodes on an industrial scale is highly possible.

  16. Scalable fabrication of high-power graphene micro-supercapacitors for flexible and on-chip energy storage

    NASA Astrophysics Data System (ADS)

    El-Kady, Maher F.; Kaner, Richard B.

    2013-02-01

    The rapid development of miniaturized electronic devices has increased the demand for compact on-chip energy storage. Microscale supercapacitors have great potential to complement or replace batteries and electrolytic capacitors in a variety of applications. However, conventional micro-fabrication techniques have proven to be cumbersome in building cost-effective micro-devices, thus limiting their widespread application. Here we demonstrate a scalable fabrication of graphene micro-supercapacitors over large areas by direct laser writing on graphite oxide films using a standard LightScribe DVD burner. More than 100 micro-supercapacitors can be produced on a single disc in 30 min or less. The devices are built on flexible substrates for flexible electronics and on-chip uses that can be integrated with MEMS or CMOS in a single chip. Remarkably, miniaturizing the devices to the microscale results in enhanced charge-storage capacity and rate capability. These micro-supercapacitors demonstrate a power density of ~200 W cm-3, which is among the highest values achieved for any supercapacitor.

  17. Scalable synthesis of hierarchical macropore-rich activated carbon microspheres assembled by carbon nanoparticles for high rate performance supercapacitors

    NASA Astrophysics Data System (ADS)

    Zhang, Dongdong; Zhao, Jianghong; Feng, Chong; Zhao, Rijie; Sun, Yahui; Guan, Taotao; Han, Baixin; Tang, Nan; Wang, Jianlong; Li, Kaixi; Qiao, Jinli; Zhang, Jiujun

    2017-02-01

    A scalable inverse-microemulsion-polymerization-phase-separation coupling method is applied to successfully prepare hierarchical macropore-rich activated carbon microspheres (ACS) using a phenolic resin (PR) precursor followed by carbonization and KOH activation for the first time. The formed ACS materials are assembled by carbon nanoparticles (CNPs). The macropores interspersed among the component CNPs are formed after removing the non-reactive solvent phase in the course of the polymerization of the reactive PR phase, which occupies ∼64% of the total pore volume (∼2.779 cm3 g-1) of the optimized ACS. In combination with mesopores (∼18% of the total pore volume), the ACS possesses meso/macropores approaching 82% of the total pore volume. Micropores are created in the component CNPs via KOH activation, showing shortened ion transport distances in the nanoscale dimension. Both the hierarchical micro/meso/macroporous structure and the inner nanoparticle morphology (short ion diffusion pathways) can significantly contribute to the rapid transport of electrolyte ions throughout the carbonaceous matrix, resulting in superior rate performance of ACS-based supercapacitors. More importantly, the energy densities of the ACS supercapacitors operating in both aqueous and organic electrolyte retain steady over a wide range of power densities varying dramatically from 0.25 to 14.5 kW kg-1 and to 7.0 kW kg-1, respectively.

  18. Scalable fabrication of high-power graphene micro-supercapacitors for flexible and on-chip energy storage.

    PubMed

    El-Kady, Maher F; Kaner, Richard B

    2013-01-01

    The rapid development of miniaturized electronic devices has increased the demand for compact on-chip energy storage. Microscale supercapacitors have great potential to complement or replace batteries and electrolytic capacitors in a variety of applications. However, conventional micro-fabrication techniques have proven to be cumbersome in building cost-effective micro-devices, thus limiting their widespread application. Here we demonstrate a scalable fabrication of graphene micro-supercapacitors over large areas by direct laser writing on graphite oxide films using a standard LightScribe DVD burner. More than 100 micro-supercapacitors can be produced on a single disc in 30 min or less. The devices are built on flexible substrates for flexible electronics and on-chip uses that can be integrated with MEMS or CMOS in a single chip. Remarkably, miniaturizing the devices to the microscale results in enhanced charge-storage capacity and rate capability. These micro-supercapacitors demonstrate a power density of ~200 W cm-3, which is among the highest values achieved for any supercapacitor.

  19. Highly flexible, transparent and self-cleanable superhydrophobic films prepared by a facile and scalable nanopyramid formation technique.

    PubMed

    Kong, Jeong-Ho; Kim, Tae-Hyun; Kim, Ji Hoon; Park, Jong-Kweon; Lee, Deug-Woo; Kim, Soo-Hyung; Kim, Jong-Man

    2014-01-01

    A facile and scalable technique to fabricate optically transparent, mechanically flexible and self-cleanable superhydrophobic films for practical solar cell applications is proposed. The superhydrophobic films were fabricated simply by transferring a transparent porous alumina layer, which was prepared using an anodic aluminium oxidation (AAO) technique, onto a polyethylene terephthalate (PET) film with a UV-curable polymer adhesive layer, followed by the subsequent formation of alumina nano pyramids (NPs) through the time-controlled chemical etching of the transferred porous alumina membrane (PAM). It was found experimentally that the proposed functional films can ensure the superhydrophobicity in the Cassie-Baxter wetting mode with superior water-repellent properties through a series of experimental observations including static contact angle (SCA), contact angle hysteresis (CAH), sliding behaviour on the tilted film, and dynamic behaviour of the liquid droplet impacting on the film. In addition to the superior surface wetting properties, an optical transmittance of ∼79% at a light wavelength of 550 nm was achieved. Furthermore, there was no significant degradation in both the surface wetting properties and morphology even after 1500-cycles of repetitive bending tests, which indicates that the proposed superhydrophobic film is mechanically robust. Finally, the practicability of the proposed self-cleanable film was proven quantitatively by observing the changes in the power conversion efficiency (PCE) of a photovoltaic device covering the film before and after the cleaning process.

  20. Highly flexible, transparent and self-cleanable superhydrophobic films prepared by a facile and scalable nanopyramid formation technique

    NASA Astrophysics Data System (ADS)

    Kong, Jeong-Ho; Kim, Tae-Hyun; Kim, Ji Hoon; Park, Jong-Kweon; Lee, Deug-Woo; Kim, Soo-Hyung; Kim, Jong-Man

    2014-01-01

    A facile and scalable technique to fabricate optically transparent, mechanically flexible and self-cleanable superhydrophobic films for practical solar cell applications is proposed. The superhydrophobic films were fabricated simply by transferring a transparent porous alumina layer, which was prepared using an anodic aluminium oxidation (AAO) technique, onto a polyethylene terephthalate (PET) film with a UV-curable polymer adhesive layer, followed by the subsequent formation of alumina nano pyramids (NPs) through the time-controlled chemical etching of the transferred porous alumina membrane (PAM). It was found experimentally that the proposed functional films can ensure the superhydrophobicity in the Cassie-Baxter wetting mode with superior water-repellent properties through a series of experimental observations including static contact angle (SCA), contact angle hysteresis (CAH), sliding behaviour on the tilted film, and dynamic behaviour of the liquid droplet impacting on the film. In addition to the superior surface wetting properties, an optical transmittance of ~79% at a light wavelength of 550 nm was achieved. Furthermore, there was no significant degradation in both the surface wetting properties and morphology even after 1500-cycles of repetitive bending tests, which indicates that the proposed superhydrophobic film is mechanically robust. Finally, the practicability of the proposed self-cleanable film was proven quantitatively by observing the changes in the power conversion efficiency (PCE) of a photovoltaic device covering the film before and after the cleaning process.

  1. Fast round-trip Mars trajectories

    NASA Technical Reports Server (NTRS)

    Wilson, Sam

    1990-01-01

    This paper is concerned with the effect of limiting the overall duration or else the one-way flight time of a round trip to Mars, as reflected in the sum of impulsive velocity increments required of the spacecraft propulsion system. Ignition-to-burnout mass ratios for a hypothetical single stage spacecraft, obtained from the rocket equation by combining these delta-V sums with appropriate values of specific impulse, are used to evaluate the relative effectiveness of four high-thrust propulsion alternatives. If the flight crew goes to the surface of Mars and stays there for the duration of their stopover, it is much cheaper (in terms of delta-V) to minimize their zero-g exposure by limiting the interplanetary transit time of a conjunction-class mission (round trip time = 800-1000 days, Mars stopover = 450-700 days) than to impose the same limit on an opposition-class mission (round trip time less than 600 days, stopover = 40 days). Using solid-core nuclear thermal propulsion to fly a conjunction-class mission, for a moderate mass penalty the interplanetary transit time (each way) probably could be limited to something in the range of 4 to 6 months, depending on the launch year.

  2. A Scalable Media Multicasting Scheme

    NASA Astrophysics Data System (ADS)

    Youwei, Zhang

    IP multicast has been proved to be unfeasible for deployment, Application Layer Multicast (ALM) Based on end multicast system is practical and more scalable than IP multicast in Internet. In this paper, an ALM protocol called Scalable multicast for High Definition streaming media (SHD) is proposed in which end to end transmission capability is fully cultivated for HD media transmission without increasing much control overhead. Similar to the transmission style of BiTtorrent, hosts only forward part of data piece according to the available bandwidth that improves the usage of bandwidth greatly. On the other hand, some novel strategies are adopted to overcome the disadvantages of BiTtorrent protocol in streaming media transmission. Data transmission between hosts is implemented in many-one transmission style in Hierarchical architecture in most circumstances. Simulations implemented on Internet-like topology indicate that SHD achieves low link stress, end to end latency and stability.

  3. A Scalable Tools Communication Infrastructure

    SciTech Connect

    Buntinas, Darius; Bosilca, George; Graham, Richard L; Vallee, Geoffroy R; Watson, Gregory R.

    2008-01-01

    The Scalable Tools Communication Infrastructure (STCI) is an open source collaborative effort intended to provide high-performance, scalable, resilient, and portable communications and process control services for a wide variety of user and system tools. STCI is aimed specifically at tools for ultrascale computing and uses a component architecture to simplify tailoring the infrastructure to a wide range of scenarios. This paper describes STCI's design philosophy, the various components that will be used to provide an STCI implementation for a range of ultrascale platforms, and a range of tool types. These include tools supporting parallel run-time environments, such as MPI, parallel application correctness tools and performance analysis tools, as well as system monitoring and management tools.

  4. Facile and Scalable Synthesis Method for High-Quality Few-Layer Graphene through Solution-Based Exfoliation of Graphite.

    PubMed

    Wee, Boon-Hong; Wu, Tong-Fei; Hong, Jong-Dal

    2017-02-08

    Here we describe a facile and scalable method for preparing defect-free graphene sheets exfoliated from graphite using the positively charged polyelectrolyte precursor poly(p-phenylenevinylene) (PPV-pre) as a stabilizer in an aqueous solution. The graphene exfoliated by PPV-pre was apparently stabilized in the solution as a form of graphene/PPV-pre (denoted to GPPV-pre), which remains in a homogeneous dispersion over a year. The thickness values of 300 selected 76% GPPV-pre flakes ranged from 1 to 10 nm, corresponding to between one and a few layers of graphene in the lateral dimensions of 1 to 2 μm. Furthermore, this approach was expected to yield a marked decrease in the density of defects in the electronic conjugation of graphene compared to that of graphene oxide (GO) obtained by Hummers' method. The positively charged GPPV-pre was employed to fabricate a poly(ethylene terephthalate) (PET) electrode layer-by-layer with negatively charged GO, yielding (GPPV-pre/GO)n film electrode. The PPV-pre and GO in the (GPPV-pre/GO)n films were simultaneously converted using hydroiodic acid vapor to fully conjugated PPV and reduced graphene oxide (RGO), respectively. The electrical conductivity of (GPPV/RGO)23 multilayer films was 483 S/cm, about three times greater than that of the (PPV/RGO)23 multilayer films (166 S/cm) comprising RGO (prepared by Hummers method). Furthermore, the superior electrical properties of GPPV were made evident, when comparing the capacitive performances of two supercapacitor systems; (polyaniline PANi/RGO)30/(GPPV/RGO)23/PET (volumetric capacitance = 216 F/cm(3); energy density = 19 mWh/cm(3); maximum power density = 498 W/cm(3)) and (PANi/RGO)30/(PPV/RGO)23/PET (152 F/cm(3); 9 mWh/cm(3); 80 W/cm(3)).

  5. A 1T-DRAM cell based on a tunnel field-effect transistor with highly-scalable pillar and surrounding gate structure

    NASA Astrophysics Data System (ADS)

    Kim, Hyungjin; Park, Byung-Gook

    2016-08-01

    In this work, a 1-transistor (1T) dynamic random access memory (DRAM) cell based on a tunnel field-effect transistor (TFET) is introduced and its operation physics demonstrated. It is structurally based on a pillar structure and surrounding gate, which gives a high scalability compared with the conventional 1T-1 capacitor (1C) DRAM cell so it can be easily made into a 4F2 cell array. The program operation is performed not by hole generation through impact ionization or gate-induced drain leakage but by hole injection from the source region unlike other 1T DRAM cells. In addition, the tunneling current mechanism of the device gives low power consumption DRAM operation and good retention characteristics to the proposed device.

  6. TRIP13 is expressed in colorectal cancer and promotes cancer cell invasion

    PubMed Central

    Kurita, Kenji; Maeda, Masao; Mansour, Mohammed A.; Kokuryo, Toshio; Uehara, Keisuke; Yokoyama, Yukihiro; Nagino, Masato; Hamaguchi, Michinari; Senga, Takeshi

    2016-01-01

    Thyroid hormone receptor interactor 13 (TRIP13) is a member of the ATPases associated with various cellular activities family of proteins and is highly conserved in a wide range of species. Recent studies have demonstrated that TRIP13 is critical for the inactivation of the spindle assembly checkpoint and is associated with the progression of certain cancers. In the present study, the role of TRIP13 in colorectal cancer (CRC) was examined. Reverse transcription-quantitative polymerase chain reaction analysis revealed that TRIP13 messenger RNA was highly expressed in multiple CRC tissues. The depletion of TRIP13 in CRC cells suppressed cell proliferation, migration and invasion. To determine whether the catalytic activity of TRIP13 was critical for cancer progression, an inactive mutant of TRIP13 was expressed in CRC cells. The invasion of cancer cells that expressed the mutant TRIP13 was significantly reduced compared with that of the wild type TRIP13-expressing cancer cells. These results indicate that TRIP13 could be a potential target for CRC treatment. PMID:28105232

  7. Katimavik Out-Trip Protocol.

    ERIC Educational Resources Information Center

    OPCAN, Montreal (Quebec).

    A supplement to the active leisure learning student manual for Katimavik (the 9-month volunteer community service and experiential learning program for 17-21 year old Canadians) provides in greater detail the procedure for preparing and implementing the Outdoor Wilderness Trip. Sections presented are definition of terms, national training,…

  8. Learning from a Bike Trip

    ERIC Educational Resources Information Center

    Koren, Mike

    2009-01-01

    In this article, the author describes a bike trip which marks the culmination of a unit reviewing map-reading capabilities. In seventh grade, students develop various map skills, including cardinal and intermediate directions, how to measure distance on a map using a scale of miles, how to interpret the legend of a map, and how to locate places…

  9. Sandia Scalable Encryption Software

    SciTech Connect

    Tarman, Thomas D.

    1997-08-13

    Sandia Scalable Encryption Library (SSEL) Version 1.0 is a library of functions that implement Sandia''s scalable encryption algorithm. This algorithm is used to encrypt Asynchronous Transfer Mode (ATM) data traffic, and is capable of operating on an arbitrary number of bits at a time (which permits scaling via parallel implementations), while being interoperable with differently scaled versions of this algorithm. The routines in this library implement 8 bit and 32 bit versions of a non-linear mixer which is compatible with Sandia''s hardware-based ATM encryptor.

  10. 30 CFR 57.14162 - Trip lights.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Trip lights. 57.14162 Section 57.14162 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND... Devices and Maintenance Requirements § 57.14162 Trip lights. On underground rail haulage, trip...

  11. 30 CFR 57.14162 - Trip lights.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Trip lights. 57.14162 Section 57.14162 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND... Devices and Maintenance Requirements § 57.14162 Trip lights. On underground rail haulage, trip...

  12. 30 CFR 57.14162 - Trip lights.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Trip lights. 57.14162 Section 57.14162 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND... Devices and Maintenance Requirements § 57.14162 Trip lights. On underground rail haulage, trip...

  13. 30 CFR 57.14162 - Trip lights.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Trip lights. 57.14162 Section 57.14162 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND... Devices and Maintenance Requirements § 57.14162 Trip lights. On underground rail haulage, trip...

  14. One-trip drum operating instruction

    SciTech Connect

    Ruff, D.T.

    1994-10-01

    The one trip system is a bagless transfer system for egress of waste from gloveboxes into 55 gallon one-trip drums. The contents of this document give an overview of the assembly, loading, and handling of the one-trip drum for use in the WRAP-1 plant.

  15. 30 CFR 57.14162 - Trip lights.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Trip lights. 57.14162 Section 57.14162 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND... Devices and Maintenance Requirements § 57.14162 Trip lights. On underground rail haulage, trip...

  16. Tourism, Field Trips and Geographic Education.

    ERIC Educational Resources Information Center

    Dilsaver, Lary M.

    In university level geography education, both a market and a need exist for "learning trips" combining the elements of a field trip with those of a commercial tour. Planning such trips involves four steps. The first of these is to establish the conditions of the tour, including identification of the topical focus, specific destinations and sites…

  17. International Virtual Field Trips: A New Direction?

    ERIC Educational Resources Information Center

    Stainfield, John; Fisher, Peter; Ford, Bob; Solem, Michael

    2000-01-01

    Traces the evolution of virtual field trips and discusses both the advantages and disadvantages of the virtual field trip. Explores three approaches to improving the interactivity of virtual field trips (interactive field exercises, generic software, and student-centered Web sites). Includes references. (CMK)

  18. Scalable Parallel Utopia

    SciTech Connect

    King, D.; Pierson, L.

    1998-10-01

    This contribution proposes a 128 bit wide interface structure clocked at approximately 80 MHz that will operate at 10 Gbps as a strawman for a 0C192C Utopia Specification. In addition, the concept of scalable width of data transfers in order to maintain manageably low clock rates is proposed.

  19. N- and S-doped high surface area carbon derived from soya chunks as scalable and efficient electrocatalysts for oxygen reduction

    PubMed Central

    Rana, Moumita; Arora, Gunjan; Gautam, Ujjal K

    2015-01-01

    Highly stable, cost-effective electrocatalysts facilitating oxygen reduction are crucial for the commercialization of membrane-based fuel cell and battery technologies. Herein, we demonstrate that protein-rich soya chunks with a high content of N, S and P atoms are an excellent precursor for heteroatom-doped highly graphitized carbon materials. The materials are nanoporous, with a surface area exceeding 1000 m2 g−1, and they are tunable in doping quantities. These materials exhibit highly efficient catalytic performance toward oxygen reduction reaction (ORR) with an onset potential of −0.045 V and a half-wave potential of −0.211 V (versus a saturated calomel electrode) in a basic medium, which is comparable to commercial Pt catalysts and is better than other recently developed metal-free carbon-based catalysts. These exhibit complete methanol tolerance and a performance degradation of merely ∼5% as compared to ∼14% for a commercial Pt/C catalyst after continuous use for 3000 s at the highest reduction current. We found that the fraction of graphitic N increases at a higher graphitization temperature, leading to the near complete reduction of oxygen. It is believed that due to the easy availability of the precursor and the possibility of genetic engineering to homogeneously control the heteroatom distribution, the synthetic strategy is easily scalable, with further improvement in performance. PMID:27877746

  20. N- and S-doped high surface area carbon derived from soya chunks as scalable and efficient electrocatalysts for oxygen reduction

    NASA Astrophysics Data System (ADS)

    Rana, Moumita; Arora, Gunjan; Gautam, Ujjal K.

    2015-02-01

    Highly stable, cost-effective electrocatalysts facilitating oxygen reduction are crucial for the commercialization of membrane-based fuel cell and battery technologies. Herein, we demonstrate that protein-rich soya chunks with a high content of N, S and P atoms are an excellent precursor for heteroatom-doped highly graphitized carbon materials. The materials are nanoporous, with a surface area exceeding 1000 m2 g-1, and they are tunable in doping quantities. These materials exhibit highly efficient catalytic performance toward oxygen reduction reaction (ORR) with an onset potential of -0.045 V and a half-wave potential of -0.211 V (versus a saturated calomel electrode) in a basic medium, which is comparable to commercial Pt catalysts and is better than other recently developed metal-free carbon-based catalysts. These exhibit complete methanol tolerance and a performance degradation of merely ˜5% as compared to ˜14% for a commercial Pt/C catalyst after continuous use for 3000 s at the highest reduction current. We found that the fraction of graphitic N increases at a higher graphitization temperature, leading to the near complete reduction of oxygen. It is believed that due to the easy availability of the precursor and the possibility of genetic engineering to homogeneously control the heteroatom distribution, the synthetic strategy is easily scalable, with further improvement in performance.

  1. Facile and Scalable Fabrication of Highly Efficient Lead Iodide Perovskite Thin-Film Solar Cells in Air Using Gas Pump Method.

    PubMed

    Ding, Bin; Gao, Lili; Liang, Lusheng; Chu, Qianqian; Song, Xiaoxuan; Li, Yan; Yang, Guanjun; Fan, Bin; Wang, Mingkui; Li, Chengxin; Li, Changjiu

    2016-08-10

    Control of the perovskite film formation process to produce high-quality organic-inorganic metal halide perovskite thin films with uniform morphology, high surface coverage, and minimum pinholes is of great importance to highly efficient solar cells. Herein, we report on large-area light-absorbing perovskite films fabrication with a new facile and scalable gas pump method. By decreasing the total pressure in the evaporation environment, the gas pump method can significantly enhance the solvent evaporation rate by 8 times faster and thereby produce an extremely dense, uniform, and full-coverage perovskite thin film. The resulting planar perovskite solar cells can achieve an impressive power conversion efficiency up to 19.00% with an average efficiency of 17.38 ± 0.70% for 32 devices with an area of 5 × 2 mm, 13.91% for devices with a large area up to 1.13 cm(2). The perovskite films can be easily fabricated in air conditions with a relative humidity of 45-55%, which definitely has a promising prospect in industrial application of large-area perovskite solar panels.

  2. SCIMITAR: Scalable Stream-Processing for Sensor Information Brokering

    DTIC Science & Technology

    2013-11-01

    paradigms, one might consider use any of the highly scalable batched Map-Reduce technologies as, for example, implemented in Hadoop [10]. Although...extremely scalable for information processing, this approach cannot pro- vide a scalable, low-latency approach to information. Hadoop needs to register...information in the Hadoop NameNode ser- vice, and then read from disk for any brokering function that could be supported by Hadoop . Whereas successful

  3. Teachers as Secondary Players: Involvement in Field Trips to Natural Environments

    NASA Astrophysics Data System (ADS)

    Alon, Nirit Lavie; Tal, Tali

    2016-07-01

    This study focused on field trips to natural environments where the teacher plays a secondary role alongside a professional guide. We investigated teachers' and field trip guides' views of the teacher's role, the teacher's actual function on the field trip, and the relationship between them. We observed field trips, interviewed teachers and guides, and administered questionnaires. We found different levels of teacher involvement, ranging from mainly supervising and giving technical help, to high involvement especially in the cognitive domain and sometimes in the social domain. Analysis of students' self-reported outcomes showed that the more students believe their teachers are involved, the higher the self-reported learning outcomes.

  4. Cost-effective scalable synthesis of mesoporous germanium particles via a redox-transmetalation reaction for high-performance energy storage devices.

    PubMed

    Choi, Sinho; Kim, Jieun; Choi, Nam-Soon; Kim, Min Gyu; Park, Soojin

    2015-02-24

    Nanostructured germanium is a promising material for high-performance energy storage devices. However, synthesizing it in a cost-effective and simple manner on a large scale remains a significant challenge. Herein, we report a redox-transmetalation reaction-based route for the large-scale synthesis of mesoporous germanium particles from germanium oxide at temperatures of 420-600 °C. We could confirm that a unique redox-transmetalation reaction occurs between Zn(0) and Ge(4+) at approximately 420 °C using temperature-dependent in situ X-ray absorption fine structure analysis. This reaction has several advantages, which include (i) the successful synthesis of germanium particles at a low temperature (∼450 °C), (ii) the accommodation of large volume changes, owing to the mesoporous structure of the germanium particles, and (iii) the ability to synthesize the particles in a cost-effective and scalable manner, as inexpensive metal oxides are used as the starting materials. The optimized mesoporous germanium anode exhibits a reversible capacity of ∼1400 mA h g(-1) after 300 cycles at a rate of 0.5 C (corresponding to the capacity retention of 99.5%), as well as stable cycling in a full cell containing a LiCoO2 cathode with a high energy density (charge capacity = 286.62 mA h cm(-3)).

  5. Rad-Hard, Miniaturized, Scalable, High-Voltage Switching Module for Power Applications Rad-Hard, Miniaturized

    NASA Technical Reports Server (NTRS)

    Adell, Philippe C.; Mojarradi, Mohammad; DelCastillo, Linda Y.; Vo, Tuan A.

    2011-01-01

    A paper discusses the successful development of a miniaturized radiation hardened high-voltage switching module operating at 2.5 kV suitable for space application. The high-voltage architecture was designed, fabricated, and tested using a commercial process that uses a unique combination of 0.25 micrometer CMOS (complementary metal oxide semiconductor) transistors and high-voltage lateral DMOS (diffusion metal oxide semiconductor) device with high breakdown voltage (greater than 650 V). The high-voltage requirements are achieved by stacking a number of DMOS devices within one module, while two modules can be placed in series to achieve higher voltages. Besides the high-voltage requirements, a second generation prototype is currently being developed to provide improved switching capabilities (rise time and fall time for full range of target voltages and currents), the ability to scale the output voltage to a desired value with good accuracy (few percent) up to 10 kV, to cover a wide range of high-voltage applications. In addition, to ensure miniaturization, long life, and high reliability, the assemblies will require intensive high-voltage electrostatic modeling (optimized E-field distribution throughout the module) to complete the proposed packaging approach and test the applicability of using advanced materials in a space-like environment (temperature and pressure) to help prevent potential arcing and corona due to high field regions. Finally, a single-event effect evaluation would have to be performed and single-event mitigation methods implemented at the design and system level or developed to ensure complete radiation hardness of the module.

  6. Texture developed during deformation of Transformation Induced Plasticity (TRIP) steels

    NASA Astrophysics Data System (ADS)

    Bhargava, M.; Shanta, C.; Asim, T.; Sushil, M.

    2015-04-01

    Automotive industry is currently focusing on using advanced high strength steels (AHSS) due to its high strength and formability for closure applications. Transformation Induced Plasticity (TRIP) steel is promising material for this application among other AHSS. The present work is focused on the microstructure development during deformation of TRIP steel sheets. To mimic complex strain path condition during forming of automotive body, Limit Dome Height (LDH) tests were conducted and samples were deformed in servo hydraulic press to find the different strain path. FEM Simulations were done to predict different strain path diagrams and compared with experimental results. There is a significant difference between experimental and simulation results as the existing material models are not applicable for TRIP steels. Micro texture studies were performed on the samples using EBSD and X-RD techniques. It was observed that austenite is transformed to martensite and texture developed during deformation had strong impact on limit strain and strain path.

  7. Influence of Powder Particle Size on the Compaction Behavior and Mechanical Properties of a High-Alloy Austenitic CrMnNi TRIP Steel During Spark Plasma Sintering

    NASA Astrophysics Data System (ADS)

    Decker, S.; Martin, S.; Krüger, L.

    2016-01-01

    In this study, varying powder particle size fractions (<25, 25 to 45, 45 to 63 µm) of a TRIP steel powder were compacted by spark plasma sintering (SPS). Densification initiated at a slightly lower temperature with decreasing particle size due to increasing green density. With decreasing powder particle size fraction, the as-sintered materials exhibited smaller grain sizes. Compression tests revealed a slight decrease of the compressive yield strength with increasing particle size and, accordingly, larger grain size. A few large deformation bands formed in bigger grains, while many thin deformation bands were formed in smaller grains. α'-Martensite nuclei formed successively inside the deformation bands, reducing the mean free path of (partial) dislocation slip. Due to the size of the deformation bands, α'-martensite formation started at lower strains with increasing particle size. When α'-martensite formation was initiated, work hardening was influenced more by α'-martensite formation than by the grain size of the steel matrix. Hence, work hardening increased with increasing particle size.

  8. TRIP13 impairs mitotic checkpoint surveillance and is associated with poor prognosis in multiple myeloma.

    PubMed

    Tao, Yi; Yang, Guang; Yang, Hongxing; Song, Dongliang; Hu, Liangning; Xie, Bingqian; Wang, Houcai; Gao, Lu; Gao, Minjie; Xu, Hongwei; Xu, Zhijian; Wu, Xiaosong; Zhang, Yiwen; Zhu, Weiliang; Zhan, Fenghuang; Shi, Jumei

    2017-02-01

    AAA-ATPase TRIP13 is one of the chromosome instability gene recently established in multiple myeloma (MM), the second most common and incurable hematological malignancy. However, the specific function of TRIP13 in MM is largely unknown. Using sequential gene expression profiling, we demonstrated that high TRIP13 expression levels were positively correlated with progression, disease relapse, and poor prognosis in MM patients. Overexpressing human TRIP13 in myeloma cells prompted cell growth and drug resistance, and overexpressing murine TRIP13, which shares 93% sequence identity with human TRIP13, led to colony formation of NIH/3T3 fibroblasts in vitro and tumor formation in vivo. Meanwhile, the knockdown of TRIP13 inhibited myeloma cell growth, induced cell apoptosis, and reduced tumor burden in xenograft MM mice. Mechanistically, we observed that the overexpression of TRIP13 abrogated the spindle checkpoint and induced proteasome-mediated degradation of MAD2 primarily through the Akt pathway. Thus, our results demonstrate that TRIP13 may serve as a biomarker for MM disease development and prognosis, making it a potential target for future therapies.

  9. Scalable Synthesis of Ag Networks with Optimized Sub-monolayer Au-Pd Nanoparticle Covering for Highly Enhanced SERS Detection and Catalysis

    PubMed Central

    Li, Tianyu; Vongehr, Sascha; Tang, Shaochun; Dai, Yuming; Huang, Xiao; Meng, Xiangkang

    2016-01-01

    Highly porous tri-metallic AgxAuyPdz networks with a sub-monolayer bimetallic Au-Pd nanoparticle coating were synthesized via a designed galvanic replacement reaction of Ag nanosponges suspended in mixed solutions of HAuCl4 and K2PdCl4. The resulting networks’ ligaments have a rough surface with bimetallic nanoparticles and nanopores due to removal of Ag. The surface morphology and composition are adjustable by the temperature and mixed solutions’ concentration. Very low combined Au and Pd atomic percentage (1−x) where x is atomic percentage of Ag leads to sub-monolayer nanoparticle coverings allowing a large number of active boundaries, nanopores, and metal-metal interfaces to be accessible. Optimization of the Au/Pd atomic ratio y/z obtains large surface-enhanced Raman scattering detection sensitivity (at y/z = 5.06) and a higher catalytic activity (at y/z = 3.55) toward reduction reactions as benchmarked with 4-nitrophenol than for most bimetallic catalysts. Subsequent optimization of x (at fixed y/z) further increases the catalytic activity to obtain a superior tri-metallic catalyst, which is mainly attributed to the synergy of several aspects including the large porosity, increased surface roughness, accessible interfaces, and hydrogen absorption capacity of nanosized Pd. This work provides a new concept for scalable synthesis and performance optimization of tri-metallic nanostructures. PMID:27845400

  10. SWIFT-scalable clustering for automated identification of rare cell populations in large, high-dimensional flow cytometry datasets, part 1: algorithm design.

    PubMed

    Naim, Iftekhar; Datta, Suprakash; Rebhahn, Jonathan; Cavenaugh, James S; Mosmann, Tim R; Sharma, Gaurav

    2014-05-01

    We present a model-based clustering method, SWIFT (Scalable Weighted Iterative Flow-clustering Technique), for digesting high-dimensional large-sized datasets obtained via modern flow cytometry into more compact representations that are well-suited for further automated or manual analysis. Key attributes of the method include the following: (a) the analysis is conducted in the multidimensional space retaining the semantics of the data, (b) an iterative weighted sampling procedure is utilized to maintain modest computational complexity and to retain discrimination of extremely small subpopulations (hundreds of cells from datasets containing tens of millions), and (c) a splitting and merging procedure is incorporated in the algorithm to preserve distinguishability between biologically distinct populations, while still providing a significant compaction relative to the original data. This article presents a detailed algorithmic description of SWIFT, outlining the application-driven motivations for the different design choices, a discussion of computational complexity of the different steps, and results obtained with SWIFT for synthetic data and relatively simple experimental data that allow validation of the desirable attributes. A companion paper (Part 2) highlights the use of SWIFT, in combination with additional computational tools, for more challenging biological problems.

  11. An electrochemical and structural study of highly uniform tin oxide nanowires fabricated by a novel, scalable solvoplasma technique as anode material for sodium ion batteries

    NASA Astrophysics Data System (ADS)

    Mukherjee, Santanu; Schuppert, Nicholas; Bates, Alex; Jasinski, Jacek; Hong, Jong-Eun; Choi, Moon Jong; Park, Sam

    2017-04-01

    A novel solvoplasma based technique was used to fabricate highly uniform SnO2 nanowires (NWs) for application as an anode in sodium-ion batteries (SIBs). This technique is scalable, rapid, and utilizes a rigorous cleaning process to produce very pure SnO2 NWs with enhanced porosity; which improves sodium-ion hosting and reaction kinetics. The batch of NWs obtained from the plasma process were named the ;as-made; sample and after cleaning the ;pure; sample. Structural characterization showed that the as-made sample has a K+ ion impurity which is absent in the pure samples. The pure samples have a higher maximum specific capacity, 400.71 mAhg-1, and Coulombic efficiency, 85%, compared to the as-made samples which have a maximum specific capacity of 174.69 mAhg-1 and Coulombic efficiency of 74% upon cycling. A study of the electrochemical impedance spectra showed that the as-made samples have a higher interfacial and diffusion resistance than the pure samples and resistances increased after 50 cycles of cell operation for both samples due to progressive electrode degradation. Specific energy vs specific power plots were employed to analyze the performance of the system with respect to the working conditions.

  12. Scalable synthesis of hierarchical hollow Li4Ti5O12 microspheres assembled by zigzag-like nanosheets for high rate lithium-ion batteries

    NASA Astrophysics Data System (ADS)

    Zhu, Kunxu; Gao, Hanyang; Hu, Guoxin; Liu, Mengjing; Wang, Haochen

    2017-02-01

    Electrochemical performance, abundance and cost are three crucial criteria to comprehensively evaluate the feasibility of Li4Ti5O12 as an electrode material for lithium-ion batteries (LIBs). Herein, hierarchical hollow Li4Ti5O12 microspheres (HLTOMs) assembled by zigzag-like nanosheets are synthesized by hydrothermal treatment of scalable lithium peroxotitanate complex solution using low-cost commercial H2TiO3 particles as titanium sources, followed by a calcination treatment. Precursor solution concentration, Li/Ti ratio, hydrothermal temperature and duration are found correlative and should be optimized to obtain pure Li4Ti5O12 products. A high yield of HLTOMs up to 120 g L-1 was achieved. Due to the unique morphology, the HLTOMs deliver an outstanding rate capability of 139, 125 and 108 mA h g-1 at 10, 20 and 30 C, respectively, and exhibit 94% capacity retention after 1000 cycles at 30C indicating excellent stability. These values are much superior to those of commercial Li4Ti5O12 particles (CLTOPs), showing HLTOMs are promising anode materials for LIBs.

  13. SWIFT—Scalable Clustering for Automated Identification of Rare Cell Populations in Large, High-Dimensional Flow Cytometry Datasets, Part 1: Algorithm Design

    PubMed Central

    Naim, Iftekhar; Datta, Suprakash; Rebhahn, Jonathan; Cavenaugh, James S; Mosmann, Tim R; Sharma, Gaurav

    2014-01-01

    We present a model-based clustering method, SWIFT (Scalable Weighted Iterative Flow-clustering Technique), for digesting high-dimensional large-sized datasets obtained via modern flow cytometry into more compact representations that are well-suited for further automated or manual analysis. Key attributes of the method include the following: (a) the analysis is conducted in the multidimensional space retaining the semantics of the data, (b) an iterative weighted sampling procedure is utilized to maintain modest computational complexity and to retain discrimination of extremely small subpopulations (hundreds of cells from datasets containing tens of millions), and (c) a splitting and merging procedure is incorporated in the algorithm to preserve distinguishability between biologically distinct populations, while still providing a significant compaction relative to the original data. This article presents a detailed algorithmic description of SWIFT, outlining the application-driven motivations for the different design choices, a discussion of computational complexity of the different steps, and results obtained with SWIFT for synthetic data and relatively simple experimental data that allow validation of the desirable attributes. A companion paper (Part 2) highlights the use of SWIFT, in combination with additional computational tools, for more challenging biological problems. © 2014 The Authors. Published by Wiley Periodicals Inc. PMID:24677621

  14. Scalable Synthesis of Ag Networks with Optimized Sub-monolayer Au-Pd Nanoparticle Covering for Highly Enhanced SERS Detection and Catalysis

    NASA Astrophysics Data System (ADS)

    Li, Tianyu; Vongehr, Sascha; Tang, Shaochun; Dai, Yuming; Huang, Xiao; Meng, Xiangkang

    2016-11-01

    Highly porous tri-metallic AgxAuyPdz networks with a sub-monolayer bimetallic Au-Pd nanoparticle coating were synthesized via a designed galvanic replacement reaction of Ag nanosponges suspended in mixed solutions of HAuCl4 and K2PdCl4. The resulting networks’ ligaments have a rough surface with bimetallic nanoparticles and nanopores due to removal of Ag. The surface morphology and composition are adjustable by the temperature and mixed solutions’ concentration. Very low combined Au and Pd atomic percentage (1‑x) where x is atomic percentage of Ag leads to sub-monolayer nanoparticle coverings allowing a large number of active boundaries, nanopores, and metal-metal interfaces to be accessible. Optimization of the Au/Pd atomic ratio y/z obtains large surface-enhanced Raman scattering detection sensitivity (at y/z = 5.06) and a higher catalytic activity (at y/z = 3.55) toward reduction reactions as benchmarked with 4-nitrophenol than for most bimetallic catalysts. Subsequent optimization of x (at fixed y/z) further increases the catalytic activity to obtain a superior tri-metallic catalyst, which is mainly attributed to the synergy of several aspects including the large porosity, increased surface roughness, accessible interfaces, and hydrogen absorption capacity of nanosized Pd. This work provides a new concept for scalable synthesis and performance optimization of tri-metallic nanostructures.

  15. Sustainable and scalable production of monodisperse and highly uniform colloidal carbonaceous spheres using sodium polyacrylate as the dispersant.

    PubMed

    Gong, Yutong; Xie, Lei; Li, Haoran; Wang, Yong

    2014-10-28

    Monodisperse, uniform colloidal carbonaceous spheres were fabricated by the hydrothermal treatment of glucose with the help of a tiny amount of sodium polyacrylate (PAANa). This synthetic strategy is effective at high glucose concentration and for scale-up experiments. The sphere size can be easily tuned by the reaction time, temperature and glucose concentration.

  16. Context-adaptive binary arithmetic coding with precise probability estimation and complexity scalability for high-efficiency video coding

    NASA Astrophysics Data System (ADS)

    Karwowski, Damian; Domański, Marek

    2016-01-01

    An improved context-based adaptive binary arithmetic coding (CABAC) is presented. The idea for the improvement is to use a more accurate mechanism for estimation of symbol probabilities in the standard CABAC algorithm. The authors' proposal of such a mechanism is based on the context-tree weighting technique. In the framework of a high-efficiency video coding (HEVC) video encoder, the improved CABAC allows 0.7% to 4.5% bitrate saving compared to the original CABAC algorithm. The application of the proposed algorithm marginally affects the complexity of HEVC video encoder, but the complexity of video decoder increases by 32% to 38%. In order to decrease the complexity of video decoding, a new tool has been proposed for the improved CABAC that enables scaling of the decoder complexity. Experiments show that this tool gives 5% to 7.5% reduction of the decoding time while still maintaining high efficiency in the data compression.

  17. Field trips in the southern Rocky Mountains, USA

    SciTech Connect

    Nelson, E.P.; Erslev, E.A.

    2004-07-01

    The theme of the 2004 GSA Annual Meeting and Exposition, 'Geoscience in a Changing World' covers both new and traditional areas of the earth sciences. The Front Range of the Rocky Mountains and the High Plains preserve an outstanding record of geological processes from Precambrian through Quaternary times, and thus served as excellent educational exhibits for the meeting. The chapters in this field guide all contain technical content as well as a field trip log describing field trip routes and stops. Of the 25 field trips offered at the Meeting. 14 are described in the guidebook, covering a wide variety of geoscience disciplines, with chapters on tectonics (Precambrian and Laramide), stratigraphy and paleoenvironments (e.g., early Paleozoic environments, Jurassic eolian environments, the K-T boundary, the famous Oligocene Florissant fossil beds), economic deposits (coal and molybdenum), geological hazards, and geoarchaeology. Two papers have been abstracted separately for the Coal Abstracts database.

  18. A low-cost, scalable, current-sensing digital headstage for high channel count μECoG

    NASA Astrophysics Data System (ADS)

    Trumpis, Michael; Insanally, Michele; Zou, Jialin; Elsharif, Ashraf; Ghomashchi, Ali; Sertac Artan, N.; Froemke, Robert C.; Viventi, Jonathan

    2017-04-01

    Objective. High channel count electrode arrays allow for the monitoring of large-scale neural activity at high spatial resolution. Implantable arrays featuring many recording sites require compact, high bandwidth front-end electronics. In the present study, we investigated the use of a small, light weight, and low cost digital current-sensing integrated circuit for acquiring cortical surface signals from a 61-channel micro-electrocorticographic (μECoG) array. Approach. We recorded both acute and chronic μECoG signal from rat auditory cortex using our novel digital current-sensing headstage. For direct comparison, separate recordings were made in the same anesthetized preparations using an analog voltage headstage. A model of electrode impedance explained the transformation between current- and voltage-sensed signals, and was used to reconstruct cortical potential. We evaluated the digital headstage using several metrics of the baseline and response signals. Main results. The digital current headstage recorded neural signal with similar spatiotemporal statistics and auditory frequency tuning compared to the voltage signal. The signal-to-noise ratio of auditory evoked responses (AERs) was significantly stronger in the current signal. Stimulus decoding based on true and reconstructed voltage signals were not significantly different. Recordings from an implanted system showed AERs that were detectable and decodable for 52 d. The reconstruction filter mitigated the thermal current noise of the electrode impedance and enhanced overall SNR. Significance. We developed and validated a novel approach to headstage acquisition that used current-input circuits to independently digitize 61 channels of μECoG measurements of the cortical field. These low-cost circuits, intended to measure photo-currents in digital imaging, not only provided a signal representing the local cortical field with virtually the same sensitivity and specificity as a traditional voltage headstage but

  19. Facile and Scalable Preparation of Graphene Oxide-Based Magnetic Hybrids for Fast and Highly Efficient Removal of Organic Dyes

    PubMed Central

    Jiao, Tifeng; Liu, Yazhou; Wu, Yitian; Zhang, Qingrui; Yan, Xuehai; Gao, Faming; Bauer, Adam J. P.; Liu, Jianzhao; Zeng, Tingying; Li, Bingbing

    2015-01-01

    This study reports the facile preparation and the dye removal efficiency of nanohybrids composed of graphene oxide (GO) and Fe3O4 nanoparticles with various geometrical structures. In comparison to previously reported GO/Fe3O4 composites prepared through the one-pot, in situ deposition of Fe3O4 nanoparticles, the GO/Fe3O4 nanohybrids reported here were obtained by taking advantage of the physical affinities between sulfonated GO and Fe3O4 nanoparticles, which allows tuning the dimensions and geometries of Fe3O4 nanoparticles in order to decrease their contact area with GO, while still maintaining the magnetic properties of the nanohybrids for easy separation and adsorbent recycling. Both the as-prepared and regenerated nanohybrids demonstrate a nearly 100% removal rate for methylene blue and an impressively high removal rate for Rhodamine B. This study provides new insights into the facile and controllable industrial scale fabrication of safe and highly efficient GO-based adsorbents for dye or other organic pollutants in a wide range of environmental-related applications. PMID:26220847

  20. Controlled Scalable Synthesis of Uniform, High-Quality Monolayer and Few-layer MoS2 Films

    PubMed Central

    Yu, Yifei; Li, Chun; Liu, Yi; Su, Liqin; Zhang, Yong; Cao, Linyou

    2013-01-01

    Two dimensional (2D) materials with a monolayer of atoms represent an ultimate control of material dimension in the vertical direction. Molybdenum sulfide (MoS2) monolayers, with a direct bandgap of 1.8 eV, offer an unprecedented prospect of miniaturizing semiconductor science and technology down to a truly atomic scale. Recent studies have indeed demonstrated the promise of 2D MoS2 in fields including field effect transistors, low power switches, optoelectronics, and spintronics. However, device development with 2D MoS2 has been delayed by the lack of capabilities to produce large-area, uniform, and high-quality MoS2 monolayers. Here we present a self-limiting approach that can grow high quality monolayer and few-layer MoS2 films over an area of centimeters with unprecedented uniformity and controllability. This approach is compatible with the standard fabrication process in semiconductor industry. It paves the way for the development of practical devices with 2D MoS2 and opens up new avenues for fundamental research. PMID:23689610

  1. A Day at the Museum: The Impact of Field Trips on Middle School Science Achievement

    ERIC Educational Resources Information Center

    Whitesell, Emilyn Ruble

    2016-01-01

    Field trips are an important feature of the United States' education system, although in the current context of high-stakes tests and school accountability, many schools are shifting resources away from enrichment. It is critical to understand how field trips and other informal learning experiences contribute to student test scores, but little…

  2. A High Performance Computing Study of a Scalable FISST-Based Approach to Multi-Target, Multi-Sensor Tracking

    NASA Astrophysics Data System (ADS)

    Hussein, I.; Wilkins, M.; Roscoe, C.; Faber, W.; Chakravorty, S.; Schumacher, P.

    2016-09-01

    Finite Set Statistics (FISST) is a rigorous Bayesian multi-hypothesis management tool for the joint detection, classification and tracking of multi-sensor, multi-object systems. Implicit within the approach are solutions to the data association and target label-tracking problems. The full FISST filtering equations, however, are intractable. While FISST-based methods such as the PHD and CPHD filters are tractable, they require heavy moment approximations to the full FISST equations that result in a significant loss of information contained in the collected data. In this paper, we review Smart Sampling Markov Chain Monte Carlo (SSMCMC) that enables FISST to be tractable while avoiding moment approximations. We study the effect of tuning key SSMCMC parameters on tracking quality and computation time. The study is performed on a representative space object catalog with varying numbers of RSOs. The solution is implemented in the Scala computing language at the Maui High Performance Computing Center (MHPCC) facility.

  3. Scalable still image coding based on wavelet

    NASA Astrophysics Data System (ADS)

    Yan, Yang; Zhang, Zhengbing

    2005-02-01

    The scalable image coding is an important objective of the future image coding technologies. In this paper, we present a kind of scalable image coding scheme based on wavelet transform. This method uses the famous EZW (Embedded Zero tree Wavelet) algorithm; we give a high-quality encoding to the ROI (region of interest) of the original image and a rough encoding to the rest. This method is applied well in limited memory space condition, and we encode the region of background according to the memory capacity. In this way, we can store the encoded image in limited memory space easily without losing its main information. Simulation results show it is effective.

  4. Depth-specific optogenetic control in vivo with a scalable, high-density μLED neural probe

    PubMed Central

    Scharf, Robert; Tsunematsu, Tomomi; McAlinden, Niall; Dawson, Martin D.; Sakata, Shuzo; Mathieson, Keith

    2016-01-01

    Controlling neural circuits is a powerful approach to uncover a causal link between neural activity and behaviour. Optogenetics has been widely adopted by the neuroscience community as it offers cell-type-specific perturbation with millisecond precision. However, these studies require light delivery in complex patterns with cellular-scale resolution, while covering a large volume of tissue at depth in vivo. Here we describe a novel high-density silicon-based microscale light-emitting diode (μLED) array, consisting of up to ninety-six 25 μm-diameter μLEDs emitting at a wavelength of 450 nm with a peak irradiance of 400 mW/mm2. A width of 100 μm, tapering to a 1 μm point, and a 40 μm thickness help minimise tissue damage during insertion. Thermal properties permit a set of optogenetic operating regimes, with ~0.5 °C average temperature increase. We demonstrate depth-dependent activation of mouse neocortical neurons in vivo, offering an inexpensive novel tool for the precise manipulation of neural activity. PMID:27334849

  5. Facile and scalable preparation of highly wear-resistance superhydrophobic surface on wood substrates using silica nanoparticles modified by VTES

    NASA Astrophysics Data System (ADS)

    Jia, Shanshan; Liu, Ming; Wu, Yiqiang; Luo, Sha; Qing, Yan; Chen, Haibo

    2016-11-01

    In this study, an efficient, facile method has been developed for fabricating superhydrophobic surfaces on wood substrates using silica nanoparticles modified by VTES. The as-prepared superhydrophobic wood surface had a water contact angle of 154° and water slide angle close to 0°. Simultaneously, this superhydrophobic wood showed highly durable and robust wear resistance when having undergone a long period of sandpaper abrasion or being scratched by a knife. Even under extreme conditions of boiling water, the superhydrophobicity of the as-prepared wood composite was preserved. Characterizations by scanning electron microscopy, energy-dispersive X-ray spectroscopy, and Fourier transform infrared spectroscopy showed that a typical and tough hierarchical micro/nanostructure was created on the wood substrate and vinyltriethoxysilane contributed to preventing the agglomeration of silica nanoparticles and serving as low-surface-free-energy substances. This superhydrophobic wood was easy to fabricate, mechanically resistant and exhibited long-term stability. Therefore, it is considered to be of significant importance in the industrial production of functional wood, especially for outdoor applications.

  6. Depth-specific optogenetic control in vivo with a scalable, high-density μLED neural probe

    NASA Astrophysics Data System (ADS)

    Scharf, Robert; Tsunematsu, Tomomi; McAlinden, Niall; Dawson, Martin D.; Sakata, Shuzo; Mathieson, Keith

    2016-06-01

    Controlling neural circuits is a powerful approach to uncover a causal link between neural activity and behaviour. Optogenetics has been widely adopted by the neuroscience community as it offers cell-type-specific perturbation with millisecond precision. However, these studies require light delivery in complex patterns with cellular-scale resolution, while covering a large volume of tissue at depth in vivo. Here we describe a novel high-density silicon-based microscale light-emitting diode (μLED) array, consisting of up to ninety-six 25 μm-diameter μLEDs emitting at a wavelength of 450 nm with a peak irradiance of 400 mW/mm2. A width of 100 μm, tapering to a 1 μm point, and a 40 μm thickness help minimise tissue damage during insertion. Thermal properties permit a set of optogenetic operating regimes, with ~0.5 °C average temperature increase. We demonstrate depth-dependent activation of mouse neocortical neurons in vivo, offering an inexpensive novel tool for the precise manipulation of neural activity.

  7. Designing a Scalable Fault Tolerance Model for High Performance Computational Chemistry: A Case Study with Coupled Cluster Perturbative Triples.

    PubMed

    van Dam, Hubertus J J; Vishnu, Abhinav; de Jong, Wibe A

    2011-01-11

    In the past couple of decades, the massive computational power provided by the most modern supercomputers has resulted in simulation of higher-order computational chemistry methods, previously considered intractable. As the system sizes continue to increase, the computational chemistry domain continues to escalate this trend using parallel computing with programming models such as Message Passing Interface (MPI) and Partitioned Global Address Space (PGAS) programming models such as Global Arrays. The ever increasing scale of these supercomputers comes at a cost of reduced Mean Time Between Failures (MTBF), currently on the order of days and projected to be on the order of hours for upcoming extreme scale systems. While traditional disk-based check pointing methods are ubiquitous for storing intermediate solutions, they suffer from high overhead of writing and recovering from checkpoints. In practice, checkpointing itself often brings the system down. Clearly, methods beyond checkpointing are imperative to handling the aggravating issue of reducing MTBF. In this paper, we address this challenge by designing and implementing an efficient fault tolerant version of the Coupled Cluster (CC) method with NWChem, using in-memory data redundancy. We present the challenges associated with our design, including an efficient data storage model, maintenance of at least one consistent data copy, and the recovery process. Our performance evaluation without faults shows that the current design exhibits a small overhead. In the presence of a simulated fault, the proposed design incurs negligible overhead in comparison to the state of the art implementation without faults.

  8. Scalable integration of Li5FeO4 towards robust, high-performance lithium-ion hybrid capacitors.

    PubMed

    Park, Min-Sik; Lim, Young-Geun; Hwang, Soo Min; Kim, Jung Ho; Kim, Jeom-Soo; Dou, Shi Xue; Cho, Jaephil; Kim, Young-Jun

    2014-11-01

    Lithium-ion hybrid capacitors have attracted great interest due to their high specific energy relative to conventional electrical double-layer capacitors. Nevertheless, the safety issue still remains a drawback for lithium-ion capacitors in practical operational environments because of the use of metallic lithium. Herein, single-phase Li5FeO4 with an antifluorite structure that acts as an alternative lithium source (instead of metallic lithium) is employed and its potential use for lithium-ion capacitors is verified. Abundant Li(+) amounts can be extracted from Li5FeO4 incorporated in the positive electrode and efficiently doped into the negative electrode during the first electrochemical charging. After the first Li(+) extraction, Li(+) does not return to the Li5FeO4 host structure and is steadily involved in the electrochemical reactions of the negative electrode during subsequent cycling. Various electrochemical and structural analyses support its superior characteristics for use as a promising lithium source. This versatile approach can yield a sufficient Li(+)-doping efficiency of >90% and improved safety as a result of the removal of metallic lithium from the cell.

  9. A Scalable Analysis Toolkit

    NASA Technical Reports Server (NTRS)

    Aiken, Alexander

    2001-01-01

    The Scalable Analysis Toolkit (SAT) project aimed to demonstrate that it is feasible and useful to statically detect software bugs in very large systems. The technical focus of the project was on a relatively new class of constraint-based techniques for analysis software, where the desired facts about programs (e.g., the presence of a particular bug) are phrased as constraint problems to be solved. At the beginning of this project, the most successful forms of formal software analysis were limited forms of automatic theorem proving (as exemplified by the analyses used in language type systems and optimizing compilers), semi-automatic theorem proving for full verification, and model checking. With a few notable exceptions these approaches had not been demonstrated to scale to software systems of even 50,000 lines of code. Realistic approaches to large-scale software analysis cannot hope to make every conceivable formal method scale. Thus, the SAT approach is to mix different methods in one application by using coarse and fast but still adequate methods at the largest scales, and reserving the use of more precise but also more expensive methods at smaller scales for critical aspects (that is, aspects critical to the analysis problem under consideration) of a software system. The principled method proposed for combining a heterogeneous collection of formal systems with different scalability characteristics is mixed constraints. This idea had been used previously in small-scale applications with encouraging results: using mostly coarse methods and narrowly targeted precise methods, useful information (meaning the discovery of bugs in real programs) was obtained with excellent scalability.

  10. High-performance flat data center network architecture based on scalable and flow-controlled optical switching system

    NASA Astrophysics Data System (ADS)

    Calabretta, Nicola; Miao, Wang; Dorren, Harm

    2016-03-01

    Traffic in data centers networks (DCNs) is steadily growing to support various applications and virtualization technologies. Multi-tenancy enabling efficient resource utilization is considered as a key requirement for the next generation DCs resulting from the growing demands for services and applications. Virtualization mechanisms and technologies can leverage statistical multiplexing and fast switch reconfiguration to further extend the DC efficiency and agility. We present a novel high performance flat DCN employing bufferless and distributed fast (sub-microsecond) optical switches with wavelength, space, and time switching operation. The fast optical switches can enhance the performance of the DCNs by providing large-capacity switching capability and efficiently sharing the data plane resources by exploiting statistical multiplexing. Benefiting from the Software-Defined Networking (SDN) control of the optical switches, virtual DCNs can be flexibly created and reconfigured by the DCN provider. Numerical and experimental investigations of the DCN based on the fast optical switches show the successful setup of virtual network slices for intra-data center interconnections. Experimental results to assess the DCN performance in terms of latency and packet loss show less than 10^-5 packet loss and 640ns end-to-end latency with 0.4 load and 16- packet size buffer. Numerical investigation on the performance of the systems when the port number of the optical switch is scaled to 32x32 system indicate that more than 1000 ToRs each with Terabit/s interface can be interconnected providing a Petabit/s capacity. The roadmap to photonic integration of large port optical switches will be also presented.

  11. Scalable optical quantum computer

    SciTech Connect

    Manykin, E A; Mel'nichenko, E V

    2014-12-31

    A way of designing a scalable optical quantum computer based on the photon echo effect is proposed. Individual rare earth ions Pr{sup 3+}, regularly located in the lattice of the orthosilicate (Y{sub 2}SiO{sub 5}) crystal, are suggested to be used as optical qubits. Operations with qubits are performed using coherent and incoherent laser pulses. The operation protocol includes both the method of measurement-based quantum computations and the technique of optical computations. Modern hybrid photon echo protocols, which provide a sufficient quantum efficiency when reading recorded states, are considered as most promising for quantum computations and communications. (quantum computer)

  12. Scalable solvers and applications

    SciTech Connect

    Ribbens, C J

    2000-10-27

    The purpose of this report is to summarize research activities carried out under Lawrence Livermore National Laboratory (LLNL) research subcontract B501073. This contract supported the principal investigator (P1), Dr. Calvin Ribbens, during his sabbatical visit to LLNL from August 1999 through June 2000. Results and conclusions from the work are summarized below in two major sections. The first section covers contributions to the Scalable Linear Solvers and hypre projects in the Center for Applied Scientific Computing (CASC). The second section describes results from collaboration with Patrice Turchi of LLNL's Chemistry and Materials Science Directorate (CMS). A list of publications supported by this subcontract appears at the end of the report.

  13. Crickets Are Not a Free Lunch: Protein Capture from Scalable Organic Side-Streams via High-Density Populations of Acheta domesticus

    PubMed Central

    Lundy, Mark E.; Parrella, Michael P.

    2015-01-01

    It has been suggested that the ecological impact of crickets as a source of dietary protein is less than conventional forms of livestock due to their comparatively efficient feed conversion and ability to consume organic side-streams. This study measured the biomass output and feed conversion ratios of house crickets (Acheta domesticus) reared on diets that varied in quality, ranging from grain-based to highly cellulosic diets. The measurements were made at a much greater population scale and density than any previously reported in the scientific literature. The biomass accumulation was strongly influenced by the quality of the diet (p<0.001), with the nitrogen (N) content, the ratio of N to acid detergent fiber (ADF) content, and the crude fat (CF) content (y=N/ADF+CF) explaining most of the variability between feed treatments (p = 0.02; R2 = 0.96). In addition, for populations of crickets that were able to survive to a harvestable size, the feed conversion ratios measured were higher (less efficient) than those reported from studies conducted at smaller scales and lower population densities. Compared to the industrial-scale production of chickens, crickets fed a poultry feed diet showed little improvement in protein conversion efficiency, a key metric in determining the ecological footprint of grain-based livestock protein. Crickets fed the solid filtrate from food waste processed at an industrial scale via enzymatic digestion were able to reach a harvestable size and achieve feed and protein efficiencies similar to that of chickens. However, crickets fed minimally-processed, municipal-scale food waste and diets composed largely of straw experienced >99% mortality without reaching a harvestable size. Therefore, the potential for A. domesticus to sustainably supplement the global protein supply, beyond what is currently produced via grain-fed chickens, will depend on capturing regionally scalable organic side-streams of relatively high-quality that are not

  14. The Goat Portage: Students' Stories and Learning from Canoe Trips.

    ERIC Educational Resources Information Center

    Horwood, Bert

    This study explores how high school students learn from their experiences in an extracurricular adventure program and illustrates how students' narrative inquiries relate to experiential learning. Twelve canoe trips were studied by participant observation methods. Data were collected from recorded interviews with students and staff, field notes,…

  15. Field Experiences for Young Children: Planning and Implementing Field Trips, Classroom Visitors and Collecting Trips.

    ERIC Educational Resources Information Center

    Schneider, Anne; Warner, Jane

    This document provides guidelines and suggestions for taking preschool children on field trips. Rationale for field trips, safety considerations, planning, preparation through classroom activities, parent involvement and keeping a field experience reference file are among the topics discussed. Examples of trips to a supermarket and to hear a high…

  16. Precise Perforation and Scalable Production of Si Particles from Low-Grade Sources for High-Performance Lithium Ion Battery Anodes.

    PubMed

    Zong, Linqi; Jin, Yan; Liu, Chang; Zhu, Bin; Hu, Xiaozhen; Lu, Zhenda; Zhu, Jia

    2016-11-09

    Alloy anodes, particularly silicon, have been intensively pursued as one of the most promising anode materials for the next generation lithium-ion battery primarily because of high specific capacity (>4000 mAh/g) and elemental abundance. In the past decade, various nanostructures with porosity or void space designs have been demonstrated to be effective to accommodate large volume expansion (∼300%) and to provide stable solid electrolyte interphase (SEI) during electrochemical cycling. However, how to produce these building blocks with precise morphology control at large scale and low cost remains a challenge. In addition, most of nanostructured silicon suffers from poor Coulombic efficiency due to a large surface area and Li ion trapping at the surface coating. Here we demonstrate a unique nanoperforation process, combining modified ball milling, annealing, and acid treating, to produce porous Si with precise and continuous porosity control (from 17% to 70%), directly from low cost metallurgical silicon source (99% purity, ∼ $1/kg). The produced porous Si coated with graphene by simple ball milling can deliver a reversible specific capacity of 1250 mAh/g over 1000 cycles at the rate of 1C, with Coulombic efficiency of first cycle over 89.5%. The porous networks also provide efficient ion and electron pathways and therefore enable excellent rate performance of 880 mAh/g at the rate of 5C. Being able to produce particles with precise porosity control through scalable processes from low-grade materials, it is expected that this nanoperforation may play a role in the next generation lithium ion battery anodes, as well as many other potential applications such as optoelectronics and thermoelectrics.

  17. Scalable IP switching based on optical interconnect

    NASA Astrophysics Data System (ADS)

    Luo, Zhixiang; Cao, Mingcui; Liu, Erwu

    2000-10-01

    IP traffic on the Internet and enterprise networks has been growing exponentially in the last several years, and much attention is being focused on the use of IP multicast for real-time multimedia applications. The current soft and general-purpose CPU-based routers face great stress since they have great latency and low forwarding speeds. Based on the ASICs, layer 2 switching provides high-speed packet forwarding. Integrating high-speed of Layer 2 switching with the flexibility of Layer 3 routing, Layer 3 switching (IP switching) has been put forward in order to avoid the performance bottleneck associated with Layer 3 forwarding. In this paper, we present a prototype system of a scalable IP switching based on scalable ATM switching fabric and optical interconnect. The IP switching system mainly consists of the input/output interface unit, scalable ATM switching fabric and IP control component. Optical interconnects between the input fan-out stage and the interconnect stage, also the interconnect stage and the output concentration stage provide high-speed data paths. And the interconnect stage is composed of 16 X 16 CMOS-SEED ATM switching modules. With 64 ports of OC-12 interface, the maximum throughput of the prototype system is about 20 million packets per second (MPPS) for 256 bytes average packet length, and the packet loss ratio is less than 10e-9. Benefiting from the scalable architecture and the optical interconnect, this IP switching system can easily scale to very large network size.

  18. What? A Field Trip on the Playground?

    ERIC Educational Resources Information Center

    Garbutt, Barb

    1983-01-01

    THE FOLLOWING IS THE FULL TEXT OF THIS DOCUMENT: In this day and age of budget problems, school districts are cutting back on many programs, one of which is field trips. Why worry? There must be dozens of trips that can be made on the playground of your school. Let's look into activities that can be accomplished there. SOIL STUDIES: Have you ever…

  19. The Case of the Field Trip Disaster

    ERIC Educational Resources Information Center

    Collins, Loucrecia; Redcross, Joseph

    2005-01-01

    For decades, the instructional field trip has been viewed as a strategy to enhance students' learning experiences. Yet what happens when an award-winning teacher is accused of choking a student while on a field trip? Tempers flare among community members, parents contact the police, and the principal is assigned the daunting task of investigating…

  20. Medusa: A Scalable MR Console Using USB

    PubMed Central

    Stang, Pascal P.; Conolly, Steven M.; Santos, Juan M.; Pauly, John M.; Scott, Greig C.

    2012-01-01

    MRI pulse sequence consoles typically employ closed proprietary hardware, software, and interfaces, making difficult any adaptation for innovative experimental technology. Yet MRI systems research is trending to higher channel count receivers, transmitters, gradient/shims, and unique interfaces for interventional applications. Customized console designs are now feasible for researchers with modern electronic components, but high data rates, synchronization, scalability, and cost present important challenges. Implementing large multi-channel MR systems with efficiency and flexibility requires a scalable modular architecture. With Medusa, we propose an open system architecture using the Universal Serial Bus (USB) for scalability, combined with distributed processing and buffering to address the high data rates and strict synchronization required by multi-channel MRI. Medusa uses a modular design concept based on digital synthesizer, receiver, and gradient blocks, in conjunction with fast programmable logic for sampling and synchronization. Medusa is a form of synthetic instrument, being reconfigurable for a variety of medical/scientific instrumentation needs. The Medusa distributed architecture, scalability, and data bandwidth limits are presented, and its flexibility is demonstrated in a variety of novel MRI applications. PMID:21954200

  1. Medusa: a scalable MR console using USB.

    PubMed

    Stang, Pascal P; Conolly, Steven M; Santos, Juan M; Pauly, John M; Scott, Greig C

    2012-02-01

    Magnetic resonance imaging (MRI) pulse sequence consoles typically employ closed proprietary hardware, software, and interfaces, making difficult any adaptation for innovative experimental technology. Yet MRI systems research is trending to higher channel count receivers, transmitters, gradient/shims, and unique interfaces for interventional applications. Customized console designs are now feasible for researchers with modern electronic components, but high data rates, synchronization, scalability, and cost present important challenges. Implementing large multichannel MR systems with efficiency and flexibility requires a scalable modular architecture. With Medusa, we propose an open system architecture using the universal serial bus (USB) for scalability, combined with distributed processing and buffering to address the high data rates and strict synchronization required by multichannel MRI. Medusa uses a modular design concept based on digital synthesizer, receiver, and gradient blocks, in conjunction with fast programmable logic for sampling and synchronization. Medusa is a form of synthetic instrument, being reconfigurable for a variety of medical/scientific instrumentation needs. The Medusa distributed architecture, scalability, and data bandwidth limits are presented, and its flexibility is demonstrated in a variety of novel MRI applications.

  2. Optimized scalable network switch

    DOEpatents

    Blumrich, Matthias A.; Chen, Dong; Coteus, Paul W.

    2010-02-23

    In a massively parallel computing system having a plurality of nodes configured in m multi-dimensions, each node including a computing device, a method for routing packets towards their destination nodes is provided which includes generating at least one of a 2m plurality of compact bit vectors containing information derived from downstream nodes. A multilevel arbitration process in which downstream information stored in the compact vectors, such as link status information and fullness of downstream buffers, is used to determine a preferred direction and virtual channel for packet transmission. Preferred direction ranges are encoded and virtual channels are selected by examining the plurality of compact bit vectors. This dynamic routing method eliminates the necessity of routing tables, thus enhancing scalability of the switch.

  3. Optimized scalable network switch

    DOEpatents

    Blumrich, Matthias A.; Chen, Dong; Coteus, Paul W.; Gara, Alan G.; Giampapa, Mark E.; Heidelberger, Philip; Steinmacher-Burow, Burkhard D.; Takken, Todd E.; Vranas, Pavlos M.

    2007-12-04

    In a massively parallel computing system having a plurality of nodes configured in m multi-dimensions, each node including a computing device, a method for routing packets towards their destination nodes is provided which includes generating at least one of a 2m plurality of compact bit vectors containing information derived from downstream nodes. A multilevel arbitration process in which downstream information stored in the compact vectors, such as link status information and fullness of downstream buffers, is used to determine a preferred direction and virtual channel for packet transmission. Preferred direction ranges are encoded and virtual channels are selected by examining the plurality of compact bit vectors. This dynamic routing method eliminates the necessity of routing tables, thus enhancing scalability of the switch.

  4. Scalable and Cost-Effective Synthesis of Highly Efficient Fe2N-Based Oxygen Reduction Catalyst Derived from Seaweed Biomass.

    PubMed

    Liu, Long; Yang, Xianfeng; Ma, Na; Liu, Haitao; Xia, Yanzhi; Chen, Chengmeng; Yang, Dongjiang; Yao, Xiangdong

    2016-03-09

    A simple and scalable synthesis of a 3D Fe2N-based nanoaerogel is reported with superior oxygen reduction reaction activity from waste seaweed biomass, addressed the growing energy scarcity. The merits are due to the synergistic effect of the 3D porous hybrid aerogel support with excellent electrical conductivity, convenient mass transport and O2 adsorption, and core/shell structured Fe2N/N-doped amorphous carbon nanoparticles.

  5. Fellows in the Middle: Fabulous Field Trips

    NASA Astrophysics Data System (ADS)

    West, Mary Lou

    2008-05-01

    Montclair State University's NSF GK-12 Program focuses on grades 7 and 8 in five urban public school districts in northern New Jersey. Each year four fieldtrips are taken by the students, middle school teachers, and graduate student Fellows. Many interdisciplinary hands-on lessons are written for use before, during and after each trip with this year's theme of Earth history. The Sterling Hill Mine trip evoked lessons on geology, economics, crystal structure, density, and pH. A virtual trip (webcam link) to scientists in the rainforest of Panama prompted critical thinking, categorizing layers and animals, and construction of model food webs. In the field trip to the NJ School of Conservation the students will build model aquifers, measure tree heights, and measure stream flow to compare to their Hackensack River. Finally the students will travel to MSU for a Math/Science Day with research talks, lab tours, hands-on activities, and a poster session. In January 2008 seventeen teachers, Fellows, and grant personnel took a field trip to China to set up collaborations with researchers and schools in Beijing and Xi'an, including the Beijing Ancient Observatory. All field trips are fabulous! Next year (IYA) our theme will be planetary science and will feature field trips to the Newark Museum's Dreyfuss Planetarium, BCC Buehler Challenger & Science Center, and star parties. We look forward to invigorating middle school science and mathematics with exciting astronomy. Funded by NSF #0638708

  6. Customer oriented SNR scalability scheme for scalable video coding

    NASA Astrophysics Data System (ADS)

    Li, Z. G.; Rahardja, S.

    2005-07-01

    Let the whole region be the whole bit rate range that customers are interested in, and a sub-region be a specific bit rate range. The weighting factor of each sub-region is determined according to customers' interest. A new type of region of interest (ROI) is defined for the SNR scalability as the gap between the coding efficiency of SNR scalability scheme and that of the state-of-the-art single layer coding for a sub-region is a monotonically non-increasing function of its weighting factor. This type of ROI is used as a performance index to design a customer oriented SNR scalability scheme. Our scheme can be used to achieve an optimal customer oriented scalable tradeoff (COST). The profit can thus be maximized.

  7. Scalable Nonlinear Compact Schemes

    SciTech Connect

    Ghosh, Debojyoti; Constantinescu, Emil M.; Brown, Jed

    2014-04-01

    In this work, we focus on compact schemes resulting in tridiagonal systems of equations, specifically the fifth-order CRWENO scheme. We propose a scalable implementation of the nonlinear compact schemes by implementing a parallel tridiagonal solver based on the partitioning/substructuring approach. We use an iterative solver for the reduced system of equations; however, we solve this system to machine zero accuracy to ensure that no parallelization errors are introduced. It is possible to achieve machine-zero convergence with few iterations because of the diagonal dominance of the system. The number of iterations is specified a priori instead of a norm-based exit criterion, and collective communications are avoided. The overall algorithm thus involves only point-to-point communication between neighboring processors. Our implementation of the tridiagonal solver differs from and avoids the drawbacks of past efforts in the following ways: it introduces no parallelization-related approximations (multiprocessor solutions are exactly identical to uniprocessor ones), it involves minimal communication, the mathematical complexity is similar to that of the Thomas algorithm on a single processor, and it does not require any communication and computation scheduling.

  8. Scalable SCPPM Decoder

    NASA Technical Reports Server (NTRS)

    Quir, Kevin J.; Gin, Jonathan W.; Nguyen, Danh H.; Nguyen, Huy; Nakashima, Michael A.; Moision, Bruce E.

    2012-01-01

    A decoder was developed that decodes a serial concatenated pulse position modulation (SCPPM) encoded information sequence. The decoder takes as input a sequence of four bit log-likelihood ratios (LLR) for each PPM slot in a codeword via a XAUI 10-Gb/s quad optical fiber interface. If the decoder is unavailable, it passes the LLRs on to the next decoder via a XAUI 10-Gb/s quad optical fiber interface. Otherwise, it decodes the sequence and outputs information bits through a 1-GB/s Ethernet UDP/IP (User Datagram Protocol/Internet Protocol) interface. The throughput for a single decoder unit is 150-Mb/s at an average of four decoding iterations; by connecting a number of decoder units in series, a decoding rate equal to that of the aggregate rate is achieved. The unit is controlled through a 1-GB/s Ethernet UDP/IP interface. This ground station decoder was developed to demonstrate a deep space optical communication link capability, and is unique in the scalable design to achieve real-time SCPP decoding at the aggregate data rate.

  9. Influence of Various Material Design Parameters on Deformation Behaviors of TRIP Steels

    SciTech Connect

    Choi, Kyoo Sil; Soulami, Ayoub; Liu, Wenning N.; Sun, Xin; Khaleel, Mohammad A.

    2010-11-02

    In this paper, the microstructure-based finite element modeling method is used as a virtual design tool in investigating the respective influence of various material design parameters on the deformation behaviors of transformation induced plasticity (TRIP) steels. For this purpose, the separate effects of several different material design parameters, such as the volume fraction and stability of austenite phase and the strengths of the constituent phases, on the ultimate tensile strength (UTS) and ductility/formability of TRIP steels are quantitatively examined using different representative volume elements (RVEs) representing different TRIP steels. The computational results suggest that higher austenite stability is helpful in enhancing the ductility and formability of TRIP steels by delaying the martensitic transformation to a later stage, whereas increase of austenite volume fraction and/or ferrite strength alone is not beneficial to improve the performance of TRIP steels. The results in this study also indicate that various material design parameters must be adjusted concurrently to develop high performance TRIP steels. For example, the austenite strength should increase over the ferrite strength in order to induce the gradual/smooth martensitic transformation, and the strength disparity between the ferrite and the freshly-formed martensite phases should decrease in order to avoid higher stress/strain concentration along the phase boundaries. The modeling approach and results presented in this paper can be helpful in providing the deformation fundamentals for the development of high performance TRIP steels.

  10. Towards a Scalable and Adaptive Application Support Platform for Large-Scale Distributed E-Sciences in High-Performance Network Environments

    SciTech Connect

    Wu, Chase Qishi; Zhu, Michelle Mengxia

    2016-06-06

    The advent of large-scale collaborative scientific applications has demonstrated the potential for broad scientific communities to pool globally distributed resources to produce unprecedented data acquisition, movement, and analysis. System resources including supercomputers, data repositories, computing facilities, network infrastructures, storage systems, and display devices have been increasingly deployed at national laboratories and academic institutes. These resources are typically shared by large communities of users over Internet or dedicated networks and hence exhibit an inherent dynamic nature in their availability, accessibility, capacity, and stability. Scientific applications using either experimental facilities or computation-based simulations with various physical, chemical, climatic, and biological models feature diverse scientific workflows as simple as linear pipelines or as complex as a directed acyclic graphs, which must be executed and supported over wide-area networks with massively distributed resources. Application users oftentimes need to manually configure their computing tasks over networks in an ad hoc manner, hence significantly limiting the productivity of scientists and constraining the utilization of resources. The success of these large-scale distributed applications requires a highly adaptive and massively scalable workflow platform that provides automated and optimized computing and networking services. This project is to design and develop a generic Scientific Workflow Automation and Management Platform (SWAMP), which contains a web-based user interface specially tailored for a target application, a set of user libraries, and several easy-to-use computing and networking toolkits for application scientists to conveniently assemble, execute, monitor, and control complex computing workflows in heterogeneous high-performance network environments. SWAMP will enable the automation and management of the entire process of scientific

  11. The Vo-Ag Spring Educational Trip

    ERIC Educational Resources Information Center

    Fanning, T. D.

    1977-01-01

    A vocational agriculture teacher discusses values, planning procedures, and logistics of an annual 6-day trip in which 40 Future Farmers of America (FFA) members visit farms, ranches, agribusiness units, and other points of interest to rural oriented youth. (JT)

  12. Application of the FETI Method to ASCI Problems: Scalability Results on a Thousand-Processors and Discussion of Highly Heterogeneous Problems

    SciTech Connect

    Bhardwaj, M.; Day, D.; Farhat, C.; Lesoinne, M.; Pierson, K; Rixen, D.

    1999-04-01

    We report on the application of the one-level FETI method to the solution of a class of structural problems associated with the Department of Energy's Accelerated Strategic Computing Initiative (ASCI). We focus on numerical and parallel scalability issues,and discuss the treatment by FETI of severe structural heterogeneities. We also report on preliminary performance results obtained on the ASCI Option Red supercomputer configured with as many as one thousand processors, for problems with as many as 5 million degrees of freedom.

  13. Cybertrips in Social Studies. Online Field Trips for All Ages.

    ERIC Educational Resources Information Center

    Mandel, Scott

    The Internet can take students on virtual field trips to anywhere earth, under the seas, out in space, or back in time. This book demonstrates how teachers can use the Internet to take students on field trips. Composed of two parts, part 1, "Preparing for the Trip," discusses the background of virtual field trips what they are, and why…

  14. 28 CFR 570.42 - Non-medical escorted trips.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Non-medical escorted trips. 570.42... RELEASE COMMUNITY PROGRAMS Escorted Trips § 570.42 Non-medical escorted trips. (a) Non-medical escorted trips allow an inmate to leave the institution under staff escort for approved, non-medical...

  15. 28 CFR 570.41 - Medical escorted trips.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Medical escorted trips. 570.41 Section... COMMUNITY PROGRAMS Escorted Trips § 570.41 Medical escorted trips. (a) Medical escorted trips are intended to provide an inmate with medical treatment not available within the institution. There are two...

  16. Field Trips as Valuable Learning Experiences in Geography Courses

    ERIC Educational Resources Information Center

    Krakowka, Amy Richmond

    2012-01-01

    Field trips have been acknowledged as valuable learning experiences in geography. This article uses Kolb's (1984) experiential learning model to discuss how students learn and how field trips can help enhance learning. Using Kolb's experiential learning theory as a guide in the design of field trips helps ensure that field trips contribute to…

  17. Transcription regulator TRIP-Br2 mediates ER stress-induced brown adipocytes dysfunction

    PubMed Central

    Qiang, Guifen; Whang Kong, Hyerim; Gil, Victoria; Liew, Chong Wee

    2017-01-01

    In contrast to white adipose tissue, brown adipose tissue (BAT) is known to play critical roles for both basal and inducible energy expenditure. Obesity is associated with reduction of BAT function; however, it is not well understood how obesity promotes BAT dysfunction, especially at the molecular level. Here we show that the transcription regulator TRIP-Br2 mediates ER stress-induced inhibition of lipolysis and thermogenesis in BAT. Using in vitro, ex vivo, and in vivo approaches, we demonstrate that obesity-induced inflammation upregulates brown adipocytes TRIP-Br2 expression via the ER stress pathway and amelioration of ER stress in mice completely abolishes high fat diet-induced upregulation of TRIP-Br2 in BAT. We find that increased TRIP-Br2 significantly inhibits brown adipocytes thermogenesis. Finally, we show that ablation of TRIP-Br2 ameliorates ER stress-induced inhibition on lipolysis, fatty acid oxidation, oxidative metabolism, and thermogenesis in brown adipocytes. Taken together, our current study demonstrates a role for TRIP-Br2 in ER stress-induced BAT dysfunction, and inhibiting TRIP-Br2 could be a potential approach for counteracting obesity-induced BAT dysfunction. PMID:28067333

  18. Predicting Ductility and Failure Modes of TRIP Steels under Different Loading Conditions

    SciTech Connect

    Choi, Kyoo Sil; Liu, Wenning N.; Sun, Xin; Khaleel, Mohammad A.

    2010-06-12

    We study the ultimate ductility and failure modes of a TRIP (TRansformation-Induced Plasticity) 800 steel under different loading conditions with an advanced micromechanics-based finite element analysis. The representative volume element (RVE) for the TRIP800 under examination is developed based on an actual microstructure obtained from scanning electron microscopy (SEM). The evolution of retained austenite during deformation process and the mechanical properties of the constituent phases of the TRIP800 steel are obtained from the synchrotron-based in-situ high-energy X-ray diffraction (HEXRD) experiments and a self-consistent (SC) model. The ductile failure of the TRIP800 under different loading conditions is predicted in the form of plastic strain localization without any prescribed failure criteria for the individual phases. Comparisons of the computational results with experimental measurements suggest that the microstructure-based finite element analysis can well capture the overall macroscopic behavior of the TRIP800 steel under different loading conditions. The methodology described in this study may be extended for studying the ultimate ductile failure mechanisms of TRIP steels as well as the effects of the various processing parameters on the macroscopic behaviors of TRIP steels.

  19. TRIP-Br1 oncoprotein inhibits autophagy, apoptosis, and necroptosis under nutrient/serum-deprived condition

    PubMed Central

    Duan, Jingjing; Lee, Soonduck; Kim, Kyeri; Park, Yeonji; Yang, Young; Kim, Keun-Il; Lim, Jong-Seok; Cheon, Chung-Il; Kang, Young-Sook; Lee, Myeong-Sok

    2015-01-01

    TRIP-Br1 oncogenic protein has been shown to have multiple biological functions in cells. In this study, we demonstrate that TRIP-Br1 functions as an oncoprotein by inhibiting autophagy, apoptosis, and necroptosis of cancer cells and eventually helping them to survive under the nutrient/serum starved condition. TRIP-Br1 expression level was significantly increased in conditions with low levels of nutrients. Nutrient depleted conditions were induced by culturing cancer cells until they were overcrowded with high cell density or in media deprived of glucose, amino acids, or serum. Among them, serum starvation significantly enhanced the expression of TRIP-Br1 only in all tested breast cancer cell lines (MCF7, MDA-MB-231, T47D, MDA-MB-435, Hs578D, BT549, and MDA-MB-435) but not in the three normal cell lines (MCF10A, HfCH8, and NIH3T3). As compared with the control cells, the introduction of TRIP-Br1 silencing siRNA into MCF7 and MDA-MB-231 cells accelerated cell death by inducing apoptosis and necroptosis. In this process, TRIP-Br1 confers resistance to serum starvation-induced cell deaths by stabilizing the XIAP protein and inhibiting cellular ROS production. Moreover, our data also show that the intracellular increase of TRIP-Br1 protein resulting from serum starvation seems to occur in part through the blockage of PI3K/AKT signaling pathway. PMID:26334958

  20. Visiting the USSR: a trip of a lifetime.

    PubMed

    Brown, Geraldine

    2012-01-01

    To Russia, who me? That is actually how it all began. A decade or more ago, I had the opportunity to visit what was then known as the Union of Soviet Socialist Republics (USSR), Russia. Although, this place held high priority on my list of places to go, I never thought such a trip was within my reach. This idea was quite fascinating to me because of the events that did happen there, including the Russian space ship Sputnik and the dog, the high stepping military officers, Red Square and the St. Basil's Cathedral. After reading a lot about Russia, I thought it would be great to see a clean place, where it was unlawful to throw paper on the streets, and ride in public transportation such as the buses, taxis and the subway system, which were immaculately clean. It was an exciting trip, one, I will always remember, but would be a difficult adjustment to make, to live.

  1. Dilution Refrigerator Technology for Scalable Quantum Computing

    DTIC Science & Technology

    2014-05-22

    has successfully designed, built, tested, and delivered a cryogen free dilution refrigerator for scalable quantum computing. This document is intended... Cryogenics , quantum computing REPORT DOCUMENTATION PAGE 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 10. SPONSOR/MONITOR’S ACRONYM(S) ARO 8. PERFORMING...W911NF-10-C-0004. High Precision Devices, Inc. has successfully designed, built, tested, and delivered a cryogen free dilution refrigerator for

  2. Analysis of electric vehicle's trip cost without late arrival

    NASA Astrophysics Data System (ADS)

    Leng, Jun-Qiang; Zhao, Lin

    2017-03-01

    In this paper, we use a car-following model to study each electric vehicle's trip cost and the corresponding total trip cost without late arrival. The numerical result show that the electricity cost has significant effects on each electric vehicle's trip cost and the corresponding total trip costs and that the effects are dependent on its time headway at the origin, but the electricity cost has no prominent effects on the minimum value of the system's total trip cost.

  3. Micromechanics of plastic deformation and phase transformation in a three-phase TRIP-assisted advanced high strength steel: Experiments and modeling

    NASA Astrophysics Data System (ADS)

    Srivastava, Ankit; Ghassemi-Armaki, Hassan; Sung, Hyokyung; Chen, Peng; Kumar, Sharvan; Bower, Allan F.

    2015-05-01

    The micromechanics of plastic deformation and phase transformation in a three-phase advanced high strength steel are analyzed both experimentally and by microstructure-based simulations. The steel examined is a three-phase (ferrite, martensite and retained austenite) quenched and partitioned sheet steel with a tensile strength of ~980 MPa. The macroscopic flow behavior and the volume fraction of martensite resulting from the austenite-martensite transformation during deformation were measured. In addition, micropillar compression specimens were extracted from the individual ferrite grains and the martensite particles, and using a flat-punch nanoindenter, stress-strain curves were obtained. Finite element simulations idealize the microstructure as a composite that contains ferrite, martensite and retained austenite. All three phases are discretely modeled using appropriate crystal plasticity based constitutive relations. Material parameters for ferrite and martensite are determined by fitting numerical predictions to the micropillar data. The constitutive relation for retained austenite takes into account contributions to the strain rate from the austenite-martensite transformation, as well as slip in both the untransformed austenite and product martensite. Parameters for the retained austenite are then determined by fitting the predicted flow stress and transformed austenite volume fraction in a 3D microstructure to experimental measurements. Simulations are used to probe the role of the retained austenite in controlling the strain hardening behavior as well as internal stress and strain distributions in the microstructure.

  4. Scalable coherent interface: Links to the future

    SciTech Connect

    Gustavson, D.B. ); Kristiansen, E. )

    1991-11-01

    Now that the Scalable Coherent Interface (SCI) has solved the bandwidth problem, what can we use it for SCI was developed to support closely coupled multiprocessors and their caches in a distributed shared-memory environment, but its scalability and the efficient generality of its architecture make it work very well over a wide range of applications. It can replace a local area network for connecting workstations on a campus. It can be powerful I/O channel for a supercomputer. It can be the processor-cache-memory-I/O connection in a highly parallel computer. It can gather data from enormous particle detectors and distribute it among thousands of processors. It can connect a desktop microprocessor to memory chips a few millimeters away, disk drivers a few meters away, and servers a few kilometers away.

  5. Scalable coherent interface: Links to the future

    SciTech Connect

    Gustavson, D.B.; Kristiansen, E.

    1991-11-01

    Now that the Scalable Coherent Interface (SCI) has solved the bandwidth problem, what can we use it for? SCI was developed to support closely coupled multiprocessors and their caches in a distributed shared-memory environment, but its scalability and the efficient generality of its architecture make it work very well over a wide range of applications. It can replace a local area network for connecting workstations on a campus. It can be powerful I/O channel for a supercomputer. It can be the processor-cache-memory-I/O connection in a highly parallel computer. It can gather data from enormous particle detectors and distribute it among thousands of processors. It can connect a desktop microprocessor to memory chips a few millimeters away, disk drivers a few meters away, and servers a few kilometers away.

  6. 41 CFR 301-71.106 - Who must sign a trip-by-trip authorization?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES AGENCY RESPONSIBILITIES 71-AGENCY TRAVEL ACCOUNTABILITY REQUIREMENTS Travel Authorization § 301-71.106 Who must sign a trip-by-trip authorization? The... acceptance of the payment. Travel expenses related to attendance at a conference A senior agency...

  7. 41 CFR 301-71.106 - Who must sign a trip-by-trip authorization?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES AGENCY RESPONSIBILITIES 71-AGENCY TRAVEL ACCOUNTABILITY REQUIREMENTS Travel Authorization § 301-71.106 Who must sign a trip-by-trip authorization? The... acceptance of the payment. Travel expenses related to attendance at a conference A senior agency...

  8. 41 CFR 301-71.106 - Who must sign a trip-by-trip authorization?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES AGENCY RESPONSIBILITIES 71-AGENCY TRAVEL ACCOUNTABILITY REQUIREMENTS Travel Authorization § 301-71.106 Who must sign a trip-by-trip authorization? The... acceptance of the payment. Travel expenses related to attendance at a conference A senior agency...

  9. 41 CFR 301-71.106 - Who must sign a trip-by-trip authorization?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES AGENCY RESPONSIBILITIES 71-AGENCY TRAVEL ACCOUNTABILITY REQUIREMENTS Travel Authorization § 301-71.106 Who must sign a trip-by-trip authorization? The... acceptance of the payment. Travel expenses related to attendance at a conference A senior agency...

  10. 41 CFR 301-71.106 - Who must sign a trip-by-trip authorization?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES AGENCY RESPONSIBILITIES 71-AGENCY TRAVEL ACCOUNTABILITY REQUIREMENTS Travel Authorization § 301-71.106 Who must sign a trip-by-trip authorization? The... acceptance of the payment. Travel expenses related to attendance at a conference A senior agency...

  11. Studying Geology of Central Texas through Web-Based Virtual Field Trips

    NASA Astrophysics Data System (ADS)

    Chan, C.; Khan, S. D.; Wellner, J. S.

    2007-12-01

    Each year over 2500 students, mainly non-science majors, take introductory geology classes at the University of Houston. Optional field trips to Central Texas for these classes provide a unique learning opportunity for students to experience geologic concepts in a real world context. The field trips visit Enchanted Rock, Inks Lake, Bee Cave Road, Lion Mountain, and Slaughter Gap. Unfortunately, only around 10% of our students participate in these field trips. We are developing a web-based virtual field trip for Central Texas to provide an additional effective learning experience for students in these classes. The module for Enchanted Rock is complete and consists of linked geological maps, satellite imagery, digital elevation models, 3-D photography, digital video, and 3-D virtual reality visualizations. The ten virtual stops focus on different geologic process and are accompanied by questions and answers. To test the efficacy of the virtual field trip, we developed a quiz to measure student learning and a survey to evaluate the website. The quiz consists of 10 questions paralleling each stop and information on student attendance on the Central Texas field trip and/or the virtual field trip. From the survey, the average time spent on the website was 26 minutes, and overall the ratings of the virtual field trip were positive. Most noticeably students responded that the information on the website was relevant to their class and that the pictures, figures, and animations were essential to the website. Although high correlation coefficients between responses were expected for some questions (i.e., 0.89 for "The content or text of the website was clear" and "The information on the website was easy to read"), some correlations were less expected: 0.77 for "The number of test questions was appropriate" and "The information on the website was easy to read," and 0.70 for "The test questions reinforced the material presented on the website" and "The information on the

  12. Design and implementation of scalable tape archiver

    NASA Technical Reports Server (NTRS)

    Nemoto, Toshihiro; Kitsuregawa, Masaru; Takagi, Mikio

    1996-01-01

    In order to reduce costs, computer manufacturers try to use commodity parts as much as possible. Mainframes using proprietary processors are being replaced by high performance RISC microprocessor-based workstations, which are further being replaced by the commodity microprocessor used in personal computers. Highly reliable disks for mainframes are also being replaced by disk arrays, which are complexes of disk drives. In this paper we try to clarify the feasibility of a large scale tertiary storage system composed of 8-mm tape archivers utilizing robotics. In the near future, the 8-mm tape archiver will be widely used and become a commodity part, since recent rapid growth of multimedia applications requires much larger storage than disk drives can provide. We designed a scalable tape archiver which connects as many 8-mm tape archivers (element archivers) as possible. In the scalable archiver, robotics can exchange a cassette tape between two adjacent element archivers mechanically. Thus, we can build a large scalable archiver inexpensively. In addition, a sophisticated migration mechanism distributes frequently accessed tapes (hot tapes) evenly among all of the element archivers, which improves the throughput considerably. Even with the failures of some tape drives, the system dynamically redistributes hot tapes to the other element archivers which have live tape drives. Several kinds of specially tailored huge archivers are on the market, however, the 8-mm tape scalable archiver could replace them. To maintain high performance in spite of high access locality when a large number of archivers are attached to the scalable archiver, it is necessary to scatter frequently accessed cassettes among the element archivers and to use the tape drives efficiently. For this purpose, we introduce two cassette migration algorithms, foreground migration and background migration. Background migration transfers cassettes between element archivers to redistribute frequently accessed

  13. Memory Scalability and Efficiency Analysis of Parallel Codes

    SciTech Connect

    Janjusic, Tommy; Kartsaklis, Christos

    2015-01-01

    Memory scalability is an enduring problem and bottleneck that plagues many parallel codes. Parallel codes designed for High Performance Systems are typically designed over the span of several, and in some instances 10+, years. As a result, optimization practices which were appropriate for earlier systems may no longer be valid and thus require careful optimization consideration. Specifically, parallel codes whose memory footprint is a function of their scalability must be carefully considered for future exa-scale systems. In this paper we present a methodology and tool to study the memory scalability of parallel codes. Using our methodology we evaluate an application s memory footprint as a function of scalability, which we coined memory efficiency, and describe our results. In particular, using our in-house tools we can pinpoint the specific application components which contribute to the application s overall memory foot-print (application data- structures, libraries, etc.).

  14. Biofortifying foods: Tripping over high hurdles

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A lofty goal for many in agriculture is the attainment of global nutritional security. Balanced nutrition would help ensure every child an opportunity to thrive. Currently, cereal grains are used as the staple caloric source in most developing countries. Unfortunately, these grains are poor sources ...

  15. Planning a pharmacy-led medical mission trip, part 2: servant leadership and team dynamics.

    PubMed

    Brown, Dana A; Brown, Daniel L; Yocum, Christine K

    2012-06-01

    While pharmacy curricula can prepare students for the cognitive domains of pharmacy practice, mastery of the affective aspects can prove to be more challenging. At the Gregory School of Pharmacy, medical mission trips have been highly effective means of impacting student attitudes and beliefs. Specifically, these trips have led to transformational changes in student leadership capacity, turning an act of service into an act of influence. Additionally, building team unity is invaluable to the overall effectiveness of the trip. Pre-trip preparation for teams includes activities such as routine team meetings, team-building activities, and implementation of committees, as a means of promoting positive team dynamics. While in the field, team dynamics can be fostered through activities such as daily debriefing sessions, team disclosure times, and provision of medical services.

  16. Trip-oriented travel time prediction (TOTTP) with historical vehicle trajectories

    NASA Astrophysics Data System (ADS)

    Xu, Tao; Li, Xiang; Claramunt, Christophe

    2017-03-01

    Accurate travel time prediction is undoubtedly of importance to both traffic managers and travelers. In highly-urbanized areas, trip-oriented travel time prediction (TOTTP) is valuable to travelers rather than traffic managers as the former usually expect to know the travel time of a trip which may cross over multiple road sections. There are two obstacles to the development of TOTTP, including traffic complexity and traffic data coverage.With large scale historical vehicle trajectory data and meteorology data, this research develops a BPNN-based approach through integrating multiple factors affecting trip travel time into a BPNN model to predict trip-oriented travel time for OD pairs in urban network. Results of experiments demonstrate that it helps discover the dominate trends of travel time changes daily and weekly, and the impact of weather conditions is non-trivial.

  17. Pursuing Scalability for hypre's Conceptual Interfaces

    SciTech Connect

    Falgout, R D; Jones, J E; Yang, U M

    2004-07-21

    The software library hypre provides high performance preconditioners and solvers for the solution of large, sparse linear systems on massively parallel computers as well as conceptual interfaces that allow users to access the library in the way they naturally think about their problems. These interfaces include a stencil-based structured interface (Struct); a semi-structured interface (semiStruct), which is appropriate for applications that are mostly structured, e.g. block structured grids, composite grids in structured adaptive mesh refinement applications, and overset grids; a finite element interface (FEI) for unstructured problems, as well as a conventional linear-algebraic interface (IJ). It is extremely important to provide an efficient, scalable implementation of these interfaces in order to support the scalable solvers of the library, especially when using tens of thousands of processors. This paper describes the data structures, parallel implementation and resulting performance of the IJ, Struct and semiStruct interfaces. It investigates their scalability, presents successes as well as pitfalls of some of the approaches and suggests ways of dealing with them.

  18. DISP: Optimizations towards Scalable MPI Startup

    SciTech Connect

    Fu, Huansong; Pophale, Swaroop S; Gorentla Venkata, Manjunath; Yu, Weikuan

    2016-01-01

    Despite the popularity of MPI for high performance computing, the startup of MPI programs faces a scalability challenge as both the execution time and memory consumption increase drastically at scale. We have examined this problem using the collective modules of Cheetah and Tuned in Open MPI as representative implementations. Previous improvements for collectives have focused on algorithmic advances and hardware off-load. In this paper, we examine the startup cost of the collective module within a communicator and explore various techniques to improve its efficiency and scalability. Accordingly, we have developed a new scalable startup scheme with three internal techniques, namely Delayed Initialization, Module Sharing and Prediction-based Topology Setup (DISP). Our DISP scheme greatly benefits the collective initialization of the Cheetah module. At the same time, it helps boost the performance of non-collective initialization in the Tuned module. We evaluate the performance of our implementation on Titan supercomputer at ORNL with up to 4096 processes. The results show that our delayed initialization can speed up the startup of Tuned and Cheetah by an average of 32.0% and 29.2%, respectively, our module sharing can reduce the memory consumption of Tuned and Cheetah by up to 24.1% and 83.5%, respectively, and our prediction-based topology setup can speed up the startup of Cheetah by up to 80%.

  19. A scalable method for the production of high-titer and high-quality adeno-associated type 9 vectors using the HSV platform

    PubMed Central

    Adamson-Small, Laura; Potter, Mark; Falk, Darin J; Cleaver, Brian; Byrne, Barry J; Clément, Nathalie

    2016-01-01

    Recombinant adeno-associated vectors based on serotype 9 (rAAV9) have demonstrated highly effective gene transfer in multiple animal models of muscular dystrophies and other neurological indications. Current limitations in vector production and purification have hampered widespread implementation of clinical candidate vectors, particularly when systemic administration is considered. In this study, we describe a complete herpes simplex virus (HSV)-based production and purification process capable of generating greater than 1 × 1014 rAAV9 vector genomes per 10-layer CellSTACK of HEK 293 producer cells, or greater than 1 × 105 vector genome per cell, in a final, fully purified product. This represents a 5- to 10-fold increase over transfection-based methods. In addition, rAAV vectors produced by this method demonstrated improved biological characteristics when compared to transfection-based production, including increased infectivity as shown by higher transducing unit-to-vector genome ratios and decreased total capsid protein amounts, shown by lower empty-to-full ratios. Together, this data establishes a significant improvement in both rAAV9 yields and vector quality. Further, the method can be readily adapted to large-scale good laboratory practice (GLP) and good manufacturing practice (GMP) production of rAAV9 vectors to enable preclinical and clinical studies and provide a platform to build on toward late-phases and commercial production. PMID:27222839

  20. MCMII and the TriP chip

    SciTech Connect

    Juan Estrada et al.

    2003-12-19

    We describe the development of the electronics that will be used to read out the Fiber Tracker and Preshower detectors in Run IIb. This electronics is needed for operation at 132ns bunch crossing, and may provide a measurement of the z coordinate of the Fiber Tracker hits when operating at 396ns bunch crossing. Specifically, we describe the design and preliminary tests of the Trip chip, MCM IIa, MCM IIb and MCM IIc. This document also serves as a user manual for the Trip chip and the MCM.

  1. Notes for Brazil sampling frame evaluation trip

    NASA Technical Reports Server (NTRS)

    Horvath, R. (Principal Investigator); Hicks, D. R. (Compiler)

    1981-01-01

    Field notes describing a trip conducted in Brazil are presented. This trip was conducted for the purpose of evaluating a sample frame developed using LANDSAT full frame images by the USDA Economic and Statistics Service for the eventual purpose of cropland production estimation with LANDSAT by the Foreign Commodity Production Forecasting Project of the AgRISTARS program. Six areas were analyzed on the basis of land use, crop land in corn and soybean, field size and soil type. The analysis indicated generally successful use of LANDSAT images for purposes of remote large area land use stratification.

  2. Predictive Process Optimization for Fracture Ductility in Automotive TRIP Steels

    NASA Astrophysics Data System (ADS)

    Gong, Jiadong

    In light of the emerging challenges in the automotive industry of meeting new energy-saving and environment-friendly requirements imposed by both the government and the society, the auto makers have been working relentlessly to reduce the weight of automobiles. While steel makers pushed out a variety of novel Advanced High Strength Steels (AHSS) to serve this market with new needs, TRIP (Transformation Induced Plasticity) steels is one of the most promising materials for auto-body due to its exceptional combination of strength and formability. However, current commercial automotive TRIP steels demonstrate relatively low hole-expansion (HE) capability, which is critical in stretch forming of various auto parts. This shortcoming on ductility has been causing fracture issues in the forming process and limits the wider applications of this steel. The kinetic theory of martensitic transformations and associated transformation plasticity is applied to the optimization of transformation stability for enhanced mechanical properties in a class of high strength galvannealed TRIP steel. This research leverages newly developed characterization and simulation capabilities, supporting computational design of high-performance steels exploiting optimized transformation plasticity for desired mechanical behaviors, especially for the hole-expansion ductility. The microstructure of the automotive TRIP sheet steels was investigated, using advanced tomographic characterization including nanoscale Local Electrode Atom Probe (LEAP) microanalysis. The microstructural basis of austenite stability, the austenite carbon concentration in particular, was quantified and correlated with measured fracture ductility through transformation plasticity constitutive laws. Plastic flow stability for enhanced local fracture ductility at high strength is sought to maintain high hole-expansion ductility, through quantifying the optimal stability and the heat-treatment process to achieve it. An additional

  3. Statistical Scalability Analysis of Communication Operations in Distributed Applications

    SciTech Connect

    Vetter, J S; McCracken, M O

    2001-02-27

    Current trends in high performance computing suggest that users will soon have widespread access to clusters of multiprocessors with hundreds, if not thousands, of processors. This unprecedented degree of parallelism will undoubtedly expose scalability limitations in existing applications, where scalability is the ability of a parallel algorithm on a parallel architecture to effectively utilize an increasing number of processors. Users will need precise and automated techniques for detecting the cause of limited scalability. This paper addresses this dilemma. First, we argue that users face numerous challenges in understanding application scalability: managing substantial amounts of experiment data, extracting useful trends from this data, and reconciling performance information with their application's design. Second, we propose a solution to automate this data analysis problem by applying fundamental statistical techniques to scalability experiment data. Finally, we evaluate our operational prototype on several applications, and show that statistical techniques offer an effective strategy for assessing application scalability. In particular, we find that non-parametric correlation of the number of tasks to the ratio of the time for individual communication operations to overall communication time provides a reliable measure for identifying communication operations that scale poorly.

  4. Scalability study of solid xenon

    SciTech Connect

    Yoo, J.; Cease, H.; Jaskierny, W. F.; Markley, D.; Pahlka, R. B.; Balakishiyeva, D.; Saab, T.; Filipenko, M.

    2015-04-01

    We report a demonstration of the scalability of optically transparent xenon in the solid phase for use as a particle detector above a kilogram scale. We employed a cryostat cooled by liquid nitrogen combined with a xenon purification and chiller system. A modified {\\it Bridgeman's technique} reproduces a large scale optically transparent solid xenon.

  5. NEWS: A trip to CERN

    NASA Astrophysics Data System (ADS)

    Ellison, A. D.

    2000-07-01

    the canteen. Over lunch we mixed with physicists of many different nationalities and backgrounds. Figure 1 Figure 1. In the afternoon we visited Microcosm, the CERN visitors centre, and the LEP control room and also the SPS. Here the students learned new applications for much of the physics of standing waves and resonance that they had been taught in the classroom. Later that night, we visited a bowling alley where momentum and collision theory were put into practice. The following morning we returned to CERN and visited the large magnet testing facility. Here again physics was brought to life. We saw superconducting magnets being assembled and tested and the students gained a real appreciation of the problems and principles involved. The afternoon was rounded off by a visit to a science museum in Geneva - well worth a visit, as some of us still use some of the apparatus on display. Friday was our last full day so we visited Chamonix in the northern Alps. In the morning, we ascended the Aiguille de Midi - by cable car. Twenty minutes and 3842 m later we emerged into 50 km h-1 winds and -10 °C temperature, not counting the -10 °C wind chill factor. A crisp packet provided an unusual demonstration of the effects of air pressure (figure 2). Figure 2 Figure 2. The views from the summit were very spectacular though a few people experienced mild altitude sickness. That afternoon the party went to the Mer de Glace. Being inside a 3 million year-old structure moving down a mountain at 3 cm per day was an interesting experience, as was a tot of whisky with 3 million year-old water. Once again the local scenery was very photogenic and the click and whirr of cameras was a constant background noise. Saturday morning saw an early start for the long drive home. Most students - and some staff - took the opportunity to catch up on their sleep. Thanks are due to many people without whom the trip would never have taken place. Anne Craige, Stuart Williams

  6. Benchmarking and parallel scalability of MANCINTAP, a Parallel High-Performance Tool For Neutron Activation Analysis in Complex 4D Scenarios

    NASA Astrophysics Data System (ADS)

    Firpo, G.; Frambati, S.; Frignani, M.; Gerra, G.

    2014-06-01

    MANCINTAP is a parallel computational tool developed by Ansaldo Nucleare to perform 4D neutron transport, activation and time-resolved dose-rate calculations in very complex geometries for CPU-intensive fission and fusion applications. MANCINTAP creates an automated link between the 3D radiation transport code MCNP5—which is used to evaluate both the neutron fluxes for activation calculations and the resulting secondary gamma dose rates—and the zero-dimensional activation code Anita2000 by handling crucial processes such as data exchange, determination of material mixtures and generation of cumulative probability distributions. A brief description of the computational tool is given here, with particular emphasis on the key technical choices underlying the project. Benchmarking of MANCINTAP has been performed in three steps: (i) against a very simplified model, where an analytical solution is available for comparison; (ii) against the well-established deterministic transport and activation code ATTILA and (iii) against experimental data obtained at the Frascati Neutron Generator (FNG) facility. An analysis of MANCINTAP scalability performances is proposed to demonstrate the robustness of its parallel structure, tailored for HPC applications, which makes it—to the best of our knowledge—a novel tool.

  7. Helping Children Form Connections through Field Trips

    ERIC Educational Resources Information Center

    Boyce, Carol Gratsch

    2006-01-01

    One of the most important things early childhood professionals can do for children is to help them form connections that promote the development of confidence and self-esteem, encourage the risk-taking that is needed to try new things, and contribute to a sense of well-being and belonging. Field trips are a wonderful way to foster these…

  8. Class Trips in Cyberspace: No Passports Required.

    ERIC Educational Resources Information Center

    Holzberg, Carol S.

    1996-01-01

    Describes examples of electronic field trips for elementary and secondary school students taking place during the 1996-97 school year. Topics include Mayan civilization, wildlife migration, geothermal hot spots, Antarctica, sailboat voyages, baseball and math, viruses, Hong Kong, and offerings from National Geographic. (LRW)

  9. School Trips: Are They Worth the Effort?

    ERIC Educational Resources Information Center

    Johnston, Robert

    2015-01-01

    Even the most basic of school trips will require booking places, arranging transport, writing to parents, collecting payments, planning activities, producing worksheets and, of course, endless risk assessments. It always leaves teachers wondering: "is it really worth all this effort?" Robert Johnston believes that every teacher should…

  10. Trip Leaders Guide. Outdoor Expeditions and Classes.

    ERIC Educational Resources Information Center

    Leister, Bob

    Written to help teachers or leaders plan and lead field trips, excursions, or expeditions which stimulate a motivation to positive action, this pamphlet provides assistance in conducting learning experiences outside the classroom. Topics and subtopics discussed include: (1) Campsites: selection; firebuilding; knives, axes, saws; neat campsites;…

  11. Reconceptualizing Electronic Field Trips: A Deweyian Perspective

    ERIC Educational Resources Information Center

    Cassady, Jerrell C.; Mullen, Laurie J.

    2006-01-01

    Electronic field tripping is a relatively new form of large-scale distance education that attempts to provide contextually rich learning materials embedded within a coherent educational content base. Using Dewey's (1943) framework for the natural learning impulses of children, we describe the potential pedagogical benefits afforded by electronic…

  12. The Educational Value of Field Trips

    ERIC Educational Resources Information Center

    Greene, Jay P.; Kisida, Brian; Bowen, Daniel H.

    2014-01-01

    The school field trip has a long history in American public education. For decades, students have piled into yellow buses to visit a variety of cultural institutions, including art, natural history, and science museums, as well as theaters, zoos, and historical sites. Schools gladly endured the expense and disruption of providing field trips…

  13. Field Trip to a Rocky Shore.

    ERIC Educational Resources Information Center

    Maine Univ., Orono. Cooperative Extension Service.

    Field trip activities designed for use on Maine's coast are provided, with brief definitions of the major physical zones to be found in this area. An introduction to the study of zonation of plants and animals living on the rocky shore is presented along with a list of the materials needed and the procedures to be followed when making a study of…

  14. Field Trips: Liability Issues and Best Practices

    ERIC Educational Resources Information Center

    McGinnis, Michelle H.; Getskow, Veronica; Dicker, Brian S.

    2011-01-01

    A field trip for preschool children can be a rewarding experience, but if not properly planned and executed it can be a legal nightmare for teachers and owners. This article will take teachers through a hypothetical outing. If one spots mistakes before the authors highlight them, great, and if not, one will learn some fine points during this…

  15. Take a Field Trip Close to Home.

    ERIC Educational Resources Information Center

    Wood, Jacalyn K.

    1986-01-01

    Describes a simple field trip taken by fourth-grade students to a local park. Aided by volunteers, students go through four learning stations dealing with rock studies, tree identification, following directions (mapping), and observation skills. Presite and postsite activities are discussed. (TW)

  16. 45 CFR 1310.20 - Trip routing.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false Trip routing. 1310.20 Section 1310.20 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION FOR CHILDREN, YOUTH AND FAMILIES, HEAD...

  17. 45 CFR 1310.20 - Trip routing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Trip routing. 1310.20 Section 1310.20 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION FOR CHILDREN, YOUTH AND FAMILIES, HEAD...

  18. Seasonal and Weather Effects on Older Drivers' Trip Distances.

    PubMed

    Smith, Glenys A; Porter, Michelle M; Cull, Andrew W; Mazer, Barbara L; Myers, Anita M; Naglie, Gary; Bédard, Michel; Tuokko, Holly A; Vrkljan, Brenda H; Gélinas, Isabelle; Marshall, Shawn C; Rapoport, Mark J

    2016-04-05

    The purpose of this study was to determine if season or weather affected the objectively measured trip distances of older drivers (≥ 70 years; n = 279) at seven Canadian sites. During winter, for all trips taken, trip distance was 7 per cent shorter when controlling for site and whether the trip occurred during the day. In addition, for trips taken within city limits, trip distance was 1 per cent shorter during winter and 5 per cent longer during rain when compared to no precipitation when controlling for weather (or season respectively), time of day, and site. At night, trip distance was about 30 per cent longer when controlling for season and site (and weather), contrary to expectations. Together, these results suggest that older Canadian drivers alter their trip distances based on season, weather conditions, and time of day, although not always in the expected direction.

  19. Scalable Synthesis of (−)-Thapsigargin

    PubMed Central

    2016-01-01

    Total syntheses of the complex, highly oxygenated sesquiterpenes thapsigargin (1) and nortrilobolide (2) are presented. Access to analogues of these promising bioactive natural products has been limited to tedious isolation and semisynthetic efforts. Elegant prior total syntheses demonstrated the feasibility of creating these entitites in 36–42 step processes. The currently reported route proceeds in a scalable and more concise fashion by utilizing two-phase terpene synthesis logic. Salient features of the work include application of the classic photosantonin rearrangement and precisely choreographed installation of the multiple oxygenations present on the guaianolide skeleton. PMID:28149952

  20. Scalable Optical-Fiber Communication Networks

    NASA Technical Reports Server (NTRS)

    Chow, Edward T.; Peterson, John C.

    1993-01-01

    Scalable arbitrary fiber extension network (SAFEnet) is conceptual fiber-optic communication network passing digital signals among variety of computers and input/output devices at rates from 200 Mb/s to more than 100 Gb/s. Intended for use with very-high-speed computers and other data-processing and communication systems in which message-passing delays must be kept short. Inherent flexibility makes it possible to match performance of network to computers by optimizing configuration of interconnections. In addition, interconnections made redundant to provide tolerance to faults.

  1. The Use of Experiential Education and Field Trips for Learning

    ERIC Educational Resources Information Center

    Gillett, Jason

    2011-01-01

    The purpose of my action research is to create meaningful virtual field trips that give students many of the same benefits as actual field trips. Since educational budget cuts are preventing students from participating in real field trips there needs to be an alternative way to deliver that content. I hope to demonstrate how I am improving my…

  2. Revisiting Virtual Field Trips: Perspectives of College Science Instructors

    ERIC Educational Resources Information Center

    Lei, Simon A.

    2015-01-01

    Field trips are an important component of upper undergraduate and graduate-level science courses, especially in the fields of biology, geoscience, and environmental science. Field trips can provide a new perspective to a course's content and quality. Science field trips can facilitate active student learning, yet often can be constrained by time,…

  3. Using Virtual Field Trips to Connect Students with University Scientists: Core Elements and Evaluation of zipTrips[TM

    ERIC Educational Resources Information Center

    Adedokun, Omolola A.; Hetzel, Kristin; Parker, Loran Carleton; Loizzo, Jamie; Burgess, Wilella D.; Robinson, J. Paul

    2012-01-01

    Physical field trips to scientists' work places have been shown to enhance student perceptions of science, scientists and science careers. Although virtual field trips (VFTs) have emerged as viable alternatives (or supplements) to traditional physical fieldtrips, little is known about the potential of virtual field trips to provide the same or…

  4. A scalable and operationally simple radical trifluoromethylation

    PubMed Central

    Beatty, Joel W.; Douglas, James J.; Cole, Kevin P.; Stephenson, Corey R. J.

    2015-01-01

    The large number of reagents that have been developed for the synthesis of trifluoromethylated compounds is a testament to the importance of the CF3 group as well as the associated synthetic challenge. Current state-of-the-art reagents for appending the CF3 functionality directly are highly effective; however, their use on preparative scale has minimal precedent because they require multistep synthesis for their preparation, and/or are prohibitively expensive for large-scale application. For a scalable trifluoromethylation methodology, trifluoroacetic acid and its anhydride represent an attractive solution in terms of cost and availability; however, because of the exceedingly high oxidation potential of trifluoroacetate, previous endeavours to use this material as a CF3 source have required the use of highly forcing conditions. Here we report a strategy for the use of trifluoroacetic anhydride for a scalable and operationally simple trifluoromethylation reaction using pyridine N-oxide and photoredox catalysis to affect a facile decarboxylation to the CF3 radical. PMID:26258541

  5. Scalable parallel communications

    NASA Technical Reports Server (NTRS)

    Maly, K.; Khanna, S.; Overstreet, C. M.; Mukkamala, R.; Zubair, M.; Sekhar, Y. S.; Foudriat, E. C.

    1992-01-01

    Coarse-grain parallelism in networking (that is, the use of multiple protocol processors running replicated software sending over several physical channels) can be used to provide gigabit communications for a single application. Since parallel network performance is highly dependent on real issues such as hardware properties (e.g., memory speeds and cache hit rates), operating system overhead (e.g., interrupt handling), and protocol performance (e.g., effect of timeouts), we have performed detailed simulations studies of both a bus-based multiprocessor workstation node (based on the Sun Galaxy MP multiprocessor) and a distributed-memory parallel computer node (based on the Touchstone DELTA) to evaluate the behavior of coarse-grain parallelism. Our results indicate: (1) coarse-grain parallelism can deliver multiple 100 Mbps with currently available hardware platforms and existing networking protocols (such as Transmission Control Protocol/Internet Protocol (TCP/IP) and parallel Fiber Distributed Data Interface (FDDI) rings); (2) scale-up is near linear in n, the number of protocol processors, and channels (for small n and up to a few hundred Mbps); and (3) since these results are based on existing hardware without specialized devices (except perhaps for some simple modifications of the FDDI boards), this is a low cost solution to providing multiple 100 Mbps on current machines. In addition, from both the performance analysis and the properties of these architectures, we conclude: (1) multiple processors providing identical services and the use of space division multiplexing for the physical channels can provide better reliability than monolithic approaches (it also provides graceful degradation and low-cost load balancing); (2) coarse-grain parallelism supports running several transport protocols in parallel to provide different types of service (for example, one TCP handles small messages for many users, other TCP's running in parallel provide high bandwidth

  6. Field trips along the Geological Transpyrenean Road

    NASA Astrophysics Data System (ADS)

    Burgio, Marion; Dekeyser, Dominique; Richert, Jean Paul; Gruneisen, Pierre; Vazquez-Prada, Diego; Lacazedieu, Annie

    2015-04-01

    GeolVal association, www.geolval.fr , in collaboration with Geoambiente association, created a serie of pedagogical explanations about Pyrenees landscapes along the road from France to Spain, linking the towns of Pau, Oloron,Jaca and Mallos de Riglos. It was a ten years work that lasted in 2008. http://www.routetranspyreneenne.com/home_f.php We can now use this "treasure" with tourists, students and mix some landscapes explanations from a road site with a little field trip along mountain in order to "touch" the rocks. We are working about the importance of field in the way the students understand geosciences and try to organize field trips that aim to simplify and make concrete some key concepts. We also began an interactive software version of this work, presented through a pilot application, made in collaboration with Total petroleum firm.

  7. TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer

    PubMed Central

    Banerjee, Rajat; Russo, Nickole; Liu, Min; Basrur, Venkatesha; Bellile, Emily; Palanisamy, Nallasivam; Scanlon, Christina S.; van Tubergen, Elizabeth; Inglehart, Ronald C.; Metwally, Tarek; Mani, Ram-Shankar; Yocum, Anastasia; Nyati, Mukesh K.; Castilho, Rogerio M.; Varambally, Sooryanarayana; Chinnaiyan, Arul M.

    2014-01-01

    Head and neck cancer (SCCHN) is a common, aggressive, treatment-resistant cancer with a high recurrence rate and mortality, but the mechanism of treatment-resistance remains unclear. Here we describe a mechanism where the AAA-ATPase TRIP13 promotes treatment-resistance. Overexpression of TRIP13 in non-malignant cells results in malignant transformation. High expression of TRIP13 in SCCHN leads to aggressive, treatment-resistant tumors and enhanced repair of DNA damage. Using mass spectrometry, we identify DNA-PKcs complex proteins that mediate non homologous end joining (NHEJ), as TRIP13 binding partners. Using repair-deficient reporter systems, we show that TRIP13 promotes NHEJ, even when homologous recombination is intact. Importantly, overexpression of TRIP13 sensitizes SCCHN to an inhibitor of DNA-PKcs. Thus, this study defines a new mechanism of treatment resistance in SCCHN and underscores the importance of targeting NHEJ to overcome treatment failure in SCCHN and potentially in other cancers that overexpress TRIP13. PMID:25078033

  8. A Scalable Database Infrastructure

    NASA Astrophysics Data System (ADS)

    Arko, R. A.; Chayes, D. N.

    2001-12-01

    The rapidly increasing volume and complexity of MG&G data, and the growing demand from funding agencies and the user community that it be easily accessible, demand that we improve our approach to data management in order to reach a broader user-base and operate more efficient and effectively. We have chosen an approach based on industry-standard relational database management systems (RDBMS) that use community-wide data specifications, where there is a clear and well-documented external interface that allows use of general purpose as well as customized clients. Rapid prototypes assembled with this approach show significant advantages over the traditional, custom-built data management systems that often use "in-house" legacy file formats, data specifications, and access tools. We have developed an effective database prototype based a public domain RDBMS (PostgreSQL) and metadata standard (FGDC), and used it as a template for several ongoing MG&G database management projects - including ADGRAV (Antarctic Digital Gravity Synthesis), MARGINS, the Community Review system of the Digital Library for Earth Science Education, multibeam swath bathymetry metadata, and the R/V Maurice Ewing onboard acquisition system. By using standard formats and specifications, and working from a common prototype, we are able to reuse code and deploy rapidly. Rather than spend time on low-level details such as storage and indexing (which are built into the RDBMS), we can focus on high-level details such as documentation and quality control. In addition, because many commercial off-the-shelf (COTS) and public domain data browsers and visualization tools have built-in RDBMS support, we can focus on backend development and leave the choice of a frontend client(s) up to the end user. While our prototype is running under an open source RDBMS on a single processor host, the choice of standard components allows this implementation to scale to commercial RDBMS products and multiprocessor servers as

  9. Photovoice as an evaluation tool for student learning on a field trip

    NASA Astrophysics Data System (ADS)

    Behrendt, Marc; Machtmes, Krisanna

    2016-05-01

    Background: Photovoice is one method that enables an educator to view an experience from a student's perspective. This study examined how teachers might use photovoice during an informal learning experience to understand the students' experiences and experiential gain. Design and methods: Participants in this study consisted of six students, three male and three female, ranging from ninth through twelfth grade at a rural Ohio high school, who attended a field trip to a biological field station for a four-day immersive science experience. Students were provided cameras to photograph what they believed was important, interesting, or significant during an immersive four-day science trip to a biological field station, individualizing their observations in ways meaningful to them, and enabling them to assimilate or accommodate the experiences to their schema. Results: Analysis identified five positive benefits to use photovoice as an evaluation tool: teachers were provided qualitative evidence to evaluate student interaction on the field trip; teachers could evaluate the students' photographs and captions to determine if the field trip met the learning objectives; students were empowered to approach the goals and objectives of the field trip by making the field trip personally relevant; students assimilated and accommodated the new observations and experiences to their own schema; students automatically reflected upon the learning experience as they captioned the photos. Conclusions: Through photovoice, the teachers were enabled to qualitatively assess each student's experience and learning from the field trip by illustrating what the students experienced and thought was significant; providing the teachers a method to evaluate all participating students, including those who are secretive or do not normally contribute to class discussions.

  10. Heat transfer in rotating serpentine passages with trips skewed to the flow

    NASA Technical Reports Server (NTRS)

    Johnson, B. V.; Wagner, J. H.; Steuber, G. D.; Yeh, F. C.

    1992-01-01

    Experiments were conducted to determine the effects of buoyancy and Coriolis forces on heat transfer in turbine blade internal coolant passages. The experiments were conducted with a large scale, multi-pass, heat transfer model with both radially inward and outward flow. Trip strips, skewed at 45 deg to the flow direction, were machined on the leading and trailing surfaces of the radial coolant passages. An analysis of the governing flow equations showed that four parameters influence the heat transfer in rotating passages: coolant-to-wall temperature, rotation number, Reynolds number, and radius-to-passage hydraulic diameter ratio. The first three of these four parameters were varied over ranges which are typical of advanced gas turbine engine operating conditions. Results were correlated and compared to previous results from similar stationary and rotating models with smooth walls and with trip strips normal to the flow direction. The heat transfer coefficients on surfaces, where the heat transfer decreased with rotation and buoyancy, decreased to as low as 40 percent of the value without rotation. However, the maximum values of the heat transfer coefficients with high rotation were only slightly above the highest levels previously obtained with the smooth wall models. It was concluded that (1) both Coriolis and buoyancy effects must be considered in turbine blade cooling designs with trip strips, (2) the effects of rotation are markedly different depending upon the flow direction, and (3) the heat transfer with skewed trip strips is less sensitive to buoyancy than the heat transfer in models with either smooth or normal trips. Therefore, skewed trip strips rather than normal trip strips are recommended and geometry-specific tests are required for accurate design information.

  11. Evaluation of pediatric community field trips.

    PubMed

    Molnar, E T; Knasel, A L

    1987-05-01

    A field trip program for junior medical students on a pediatric clinical clerkship acquainted students with the care of normal and handicapped children in community settings of school, day care center, residential treatment, or diagnostic facilities.A program evaluation by pre and post-trip survey demonstrated a positive change in students' knowledge and attitude in general, which was unaffected by such factors as sex, previous experience in a medical setting, and previous experience with handicapped children.As an integral part of the pediatric clerkship, the field trip appears to have been a positive experience for students, as it met their educational and emotional needs. Subjective evaluation indicated that many students formed insightful and compassionate judgments about handicapped children.Although the increase in knowledge and sensitivity of the students, as reflected in the pre-and post-test, was not statistically significant, the benefit to the students, to the personnel of the agencies, and ultimately to the children and families with whom they dealt during their professional careers was important.

  12. Evaluation of Pediatric Community Field Trips

    PubMed Central

    Molnar, Eva T.; Knasel, Anne L.

    1987-01-01

    A field trip program for junior medical students on a pediatric clinical clerkship acquainted students with the care of normal and handicapped children in community settings of school, day care center, residential treatment, or diagnostic facilities. A program evaluation by pre and post-trip survey demonstrated a positive change in students' knowledge and attitude in general, which was unaffected by such factors as sex, previous experience in a medical setting, and previous experience with handicapped children. As an integral part of the pediatric clerkship, the field trip appears to have been a positive experience for students, as it met their educational and emotional needs. Subjective evaluation indicated that many students formed insightful and compassionate judgments about handicapped children. Although the increase in knowledge and sensitivity of the students, as reflected in the pre-and post-test, was not statistically significant, the benefit to the students, to the personnel of the agencies, and ultimately to the children and families with whom they dealt during their professional careers was important. PMID:3586049

  13. Scrutinized: The TRIPS Agreement and Public Health

    PubMed Central

    Subhan, Junaid

    2006-01-01

    SUMMARY The World Trade Organization’s (WTO’s) Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS) of 1994 seeks to implement a uniform set of intellectual property protection across member nations to provide greater stability in international economic relations. Critics argue that the TRIPS agreement provides unnecessarily strong protection of intellectual property rights which serves to prevent the ill in developing nations from having access to affordable essential medications. The first recommendation that this paper makes is to provide two sets of intellectual property protection, one that applies to essential medications such as AIDS drugs and certain antibiotics and another that applies to drugs that treat non-life threatening conditions. The second recommendation builds upon the first recommendation: if two sets of intellectual property protection legislation are enacted, patents on essential medications should be restricted to patents on processes rather than the product itself. The third recommendation seeks to amend the language of the TRIPS agreement to make it obligatory for member nations to implement provisions on compulsory licensing within their domestic legislation. PMID:18523624

  14. Career-focused field trips as experienced by at-risk rural students: A case study

    NASA Astrophysics Data System (ADS)

    Hutson, Tommye L.

    A lack of recent research focused on field trips as pedagogy in K-12 settings established the foundation for this work. The research design followed multiple-case case study model. The participants were four male students from a small rural high school in central Texas. Each participant, previously labeled as academically "at-risk", had identified an inability to describe connections between academic science content as presented in their common classes and future jobs, vocational training, and/or careers requiring higher education. Because the participants had no directed field excursions addressing this desirable knowledge and/or skill, a career-focused field trip was designed to address the self-identified deficit reported by the participants. The specific research questions were: (1) How does the ability to describe connections between academic science content (biology, chemistry, and physics) and future careers change as rural students experience a purposeful excursion to a post-secondary facility providing vocational training? (2) When do the connection(s) between content and future careers become evident to students? (3) What effects or impact do newly discovered connections have on rural students' aspirations with regard to future career or higher education options? Data were gathered using existing school records, an initial survey, one-to-one interviews conducted before and after the field trip, focus groups conducted before and after the field trip, and observations during the field trip. Data analysis revealed that all participants were able to describe various connections between academic content and careers after the field trip, as well as identify a specific incident that initially established those connections. In addition, all of the participants reported discovering options for careers during the field trip not previously realized or considered. Each participant indicated that they found field trips to be effective. As a result of their singular

  15. Visual exploration of big spatio-temporal urban data: a study of New York City taxi trips.

    PubMed

    Ferreira, Nivan; Poco, Jorge; Vo, Huy T; Freire, Juliana; Silva, Cláudio T

    2013-12-01

    As increasing volumes of urban data are captured and become available, new opportunities arise for data-driven analysis that can lead to improvements in the lives of citizens through evidence-based decision making and policies. In this paper, we focus on a particularly important urban data set: taxi trips. Taxis are valuable sensors and information associated with taxi trips can provide unprecedented insight into many different aspects of city life, from economic activity and human behavior to mobility patterns. But analyzing these data presents many challenges. The data are complex, containing geographical and temporal components in addition to multiple variables associated with each trip. Consequently, it is hard to specify exploratory queries and to perform comparative analyses (e.g., compare different regions over time). This problem is compounded due to the size of the data-there are on average 500,000 taxi trips each day in NYC. We propose a new model that allows users to visually query taxi trips. Besides standard analytics queries, the model supports origin-destination queries that enable the study of mobility across the city. We show that this model is able to express a wide range of spatio-temporal queries, and it is also flexible in that not only can queries be composed but also different aggregations and visual representations can be applied, allowing users to explore and compare results. We have built a scalable system that implements this model which supports interactive response times; makes use of an adaptive level-of-detail rendering strategy to generate clutter-free visualization for large results; and shows hidden details to the users in a summary through the use of overlay heat maps. We present a series of case studies motivated by traffic engineers and economists that show how our model and system enable domain experts to perform tasks that were previously unattainable for them.

  16. Scalable large format 3D displays

    NASA Astrophysics Data System (ADS)

    Chang, Nelson L.; Damera-Venkata, Niranjan

    2010-02-01

    We present a general framework for the modeling and optimization of scalable large format 3-D displays using multiple projectors. Based on this framework, we derive algorithms that can robustly optimize the visual quality of an arbitrary combination of projectors (e.g. tiled, superimposed, combinations of the two) without manual adjustment. The framework creates for the first time a new unified paradigm that is agnostic to a particular configuration of projectors yet robustly optimizes for the brightness, contrast, and resolution of that configuration. In addition, we demonstrate that our algorithms support high resolution stereoscopic video at real-time interactive frame rates achieved on commodity graphics hardware. Through complementary polarization, the framework creates high quality multi-projector 3-D displays at low hardware and operational cost for a variety of applications including digital cinema, visualization, and command-and-control walls.

  17. Network selection, Information filtering and Scalable computation

    NASA Astrophysics Data System (ADS)

    Ye, Changqing

    -complete factorizations, possibly with a high percentage of missing values. This promotes additional sparsity beyond rank reduction. Computationally, we design methods based on a ``decomposition and combination'' strategy, to break large-scale optimization into many small subproblems to solve in a recursive and parallel manner. On this basis, we implement the proposed methods through multi-platform shared-memory parallel programming, and through Mahout, a library for scalable machine learning and data mining, for mapReduce computation. For example, our methods are scalable to a dataset consisting of three billions of observations on a single machine with sufficient memory, having good timings. Both theoretical and numerical investigations show that the proposed methods exhibit significant improvement in accuracy over state-of-the-art scalable methods.

  18. Real Students and Virtual Field Trips

    NASA Astrophysics Data System (ADS)

    de Paor, D. G.; Whitmeyer, S. J.; Bailey, J. E.; Schott, R. C.; Treves, R.; Scientific Team Of Www. Digitalplanet. Org

    2010-12-01

    Field trips have always been one of the major attractions of geoscience education, distinguishing courses in geology, geography, oceanography, etc., from laboratory-bound sciences such as nuclear physics or biochemistry. However, traditional field trips have been limited to regions with educationally useful exposures and to student populations with the necessary free time and financial resources. Two-year or commuter colleges serving worker-students cannot realistically insist on completion of field assignments and even well-endowed universities cannot take students to more than a handful of the best available field localities. Many instructors have attempted to bring the field into the classroom with the aid of technology. So-called Virtual Field Trips (VFTs) cannot replace the real experience for those that experience it but they are much better than nothing at all. We have been working to create transformative improvements in VFTs using four concepts: (i) self-drive virtual vehicles that students use to navigate the virtual globe under their own control; (ii) GigaPan outcrops that reveal successively more details views of key locations; (iii) virtual specimens scanned from real rocks, minerals, and fossils; and (iv) embedded assessment via logging of student actions. Students are represented by avatars of their own choosing and travel either together in a virtual field vehicle, or separately. When they approach virtual outcrops, virtual specimens become collectable and can be examined using Javascript controls that change magnification and orientation. These instructional resources are being made available via a new server under the domain name www.DigitalPlanet.org. The server will log student progress and provide immediate feedback. We aim to disseminate these resources widely and welcome feedback from instructors and students.

  19. Round-Trip Solar Electric Propulsion Missions for Mars Sample Return

    NASA Technical Reports Server (NTRS)

    Bailey, Zachary J.; Sturm, Erick J.; Kowalkowski, Theresa D.; Lock, Robert E.; Woolley, Ryan C.; Nicholas, Austin K.

    2014-01-01

    Mars Sample Return (MSR) missions could benefit from the high specific impulse of Solar Electric Propulsion (SEP) to achieve lower launch masses than with chemical propulsion. SEP presents formulation challenges due to the coupled nature of launch vehicle performance, propulsion system, power system, and mission timeline. This paper describes a SEP orbiter-sizing tool, which models spacecraft mass & timeline in conjunction with low thrust round-trip Earth-Mars trajectories, and presents selected concept designs. A variety of system designs are possible for SEP MSR orbiters, with large dry mass allocations, similar round-trip durations to chemical orbiters, and reduced design variability between opportunities.

  20. Predictors of trips to food destinations

    PubMed Central

    2012-01-01

    Background Food environment studies have focused on ethnic and income disparities in food access. Few studies have investigated distance travelled for food and did not aim to inform the geographic scales at which to study the relationship between food environments and obesity. Further, studies have not considered neighborhood design as a predictor of food purchasing behavior. Methods Atlanta residents (N = 4800) who completed a travel diary and reported purchasing or consuming food at one of five food locations were included in the analyses. A total of 11,995 food-related trips were reported. Using mixed modeling to adjust for clustering of trips by participants and households, person-level variables (e.g. demographics), neighborhood-level urban form measures, created in GIS, and trip characteristics (e.g. time of day, origin and destination) were investigated as correlates of distance travelled for food and frequency of grocery store and fast food outlet trips. Results Mean travel distance for food ranged from 4.5 miles for coffee shops to 6.3 miles for superstores. Type of store, urban form, type of tour, day of the week and ethnicity were all significantly related to distance travelled for food. Origin and destination environment, type of tour, day of week, age, gender, income, ethnicity, vehicle access and obesity status were all significantly related to visiting a grocery store. Home neighborhood environment, day of week, type of tour, gender, income, education level, age, and obesity status were all significantly related to likelihood of visiting a fastfood outlet. Conclusions The present study demonstrated that people travel sizeable distances for food and this distance is related to urban. Results suggest that researchers need to employ different methods to characterize food environments than have been used to assess urban form in studies of physical activity. Food is most often purchased while traveling from locations other than home, so future studies

  1. Hunton Group core workshop and field trip

    SciTech Connect

    Johnson, K.S.

    1993-12-31

    The Late Ordovician-Silurian-Devonian Hunton Group is a moderately thick sequence of shallow-marine carbonates deposited on the south edge of the North American craton. This rock unit is a major target for petroleum exploration and reservoir development in the southern Midcontinent. The workshop described here was held to display cores, outcrop samples, and other reservoir-characterization studies of the Hunton Group and equivalent strata throughout the region. A field trip was organized to complement the workshop by allowing examination of excellent outcrops of the Hunton Group of the Arbuckle Mountains.

  2. Methods for analysis of passenger trip performance in a complex networked transportation system

    NASA Astrophysics Data System (ADS)

    Wang, Danyi

    2007-12-01

    follows: 1. High passenger trip delays are disproportionately generated by cancelled flights and missed connections. Passengers scheduled on cancelled flights or missed connections represent 3 percent of total enplanements, but generated 45 percent of total passenger trip delay. On average, passengers scheduled on cancelled flights experienced 607 minutes delay, and passengers who missed the connections experienced 341 minutes delay in 2006. The heavily skewed distribution of passenger trip delay reveals the fact that a small proportion of passengers experience heavy delays, which can not be reflected by flight-based performance metrics. 2. Trend analysis for passenger trip delays from 2000 to 2006 shows the increase in flight operations slowed down and leveled off in 2006, while enplanements kept increasing. This is due to the continuous increase in load factor. Load factor has increased from 69% in 2003 to 80% in 2006. Passenger performance is very sensitive to changes in flight operations: annual total passenger trip delay was increased by 17% and 7% from 2004 to 2005, and from 2005 to 2006, while flight operations barely increased (0.5% from 2004 to 2005, and no increase from 2005 to 2006) during the same time period. 3. Passenger trip delay is shown to have an asymmetric performance of passenger trip delay in terms of routes. Seventeen percent of the 1030 routes generated 50 percent of total passenger trip delays. An interesting observation is that routes between the New York metropolitan area and the Washington D.C. metropolitan area have the highest average passenger trip delays in the system. 4. In terms of airports, there is also an asymmetric performance of passenger trip delay. Nine of the 35 busiest airports generated 50 percent of total passenger trip delays. Some airports, especially major hubs, impact the passenger trip delays significantly more than others. Recognition of this asymmetric performance can help reduce the total passenger trip delay

  3. Characterization of the Fracture Toughness of TRIP 800 Sheet Steels Using Microstructure-Based Finite Element Analysis

    SciTech Connect

    Soulami, Ayoub; Choi, Kyoo Sil; Liu, Wenning N.; Sun, Xin; Khaleel, Mohammad A.

    2009-04-01

    Recently, several studies conducted by automotive industry revealed the tremendous advantages of Advanced High Strength Steels (AHSS). TRansformation Induced Plasticity (TRIP) steel is one of the typical representative of AHSS. This kind of materials exhibits high strength as well as high formability. Analyzing the crack behaviour in TRIP steels is a challenging task due to the microstructure level inhomogeneities between the different phases (Ferrite, Bainite, Austenite, Martensite) that constitute these materials. This paper aims at investigating the fracture resistance of TRIP steels. For this purpose, a micromechanical finite element model is developed based on the actual microstructure of a TRIP 800 steel. Uniaxial tensile tests on TRIP 800 sheet notched specimens were also conducted and tensile properties and R-curves (Resistance curves) were determined. The comparison between simulation and experimental results leads us to the conclusion that the method using microstructure-based representative volume element (RVE) captures well enough the complex behavior of TRIP steels. The effect of phase transformation, which occurs during the deformation process, on the toughness is observed and discussed.

  4. Venus round trip using solar sail

    NASA Astrophysics Data System (ADS)

    Zhu, KaiJian; Zhang, RongZhi; Xu, Dong; Wang, JiaSong; Li, ShaoMin

    2012-08-01

    Trajectory optimization and simulation is performed for Venus round trip (VeRT) mission using solar sail propulsion. Solar gravity is included but atmospheric drag and shadowing effects are neglected in the planet-centered escape and capture stages. The spacecraft starts from the Geostationary orbit (GEO) at a predetermined time to prepare a good initial condition for the Earth-Venus transfer, although the launch window is not an issue for spacecraft with solar sails. The Earth-Venus phase and the return trip are divided into three segments. Two methods are adopted to maintain the mission trajectory for the VeRT mission and then compared through a numerical simulation. According to the first approach, Planet-centered and heliocentric maneuvers are modeled using a set of blended analytical control laws instead of the optimal control techniques. The second procedure is the Direct Attitude Angle Optimization in which the attitude angles of the solar sail are adopted as the optimization variables during the heliocentric transfer. Although neither of the two methods guarantees a globally optimal trajectory, they are more efficient and will produce a near-optimal solution if employed properly. The second method has produced a better result for the minimum-time transfer of the VeRT mission demonstrating the effectiveness of the methods in the preliminary design of the complex optimal interplanetary orbit transfers.

  5. Mediating cultural borders during science field trips

    NASA Astrophysics Data System (ADS)

    Lebak, Kimberly

    2007-10-01

    In this paper, I analyze teacher and student roles in the teaching and learning of science at an informal learning center, The Outdoor Classroom. As a white middle class informal learning science teacher, I examine my struggles to teach science to students across boundaries of race, class, gender, and experience with the outdoors during field trips. Through the field trip I did not have the time or face-to-face experience to make sense of the students' culture, see their culture in terms of capital, and align my enactment to benefit their learning. Likewise, the students did not have the time or face-to-face experience with me in order to adapt their cultural capital and build the essential stocks of symbolic and social capital. This research demonstrates how the classroom teacher draws upon previous transactions and emotions to successfully engage her students in practices that promote the participation and learning of science. Through creating culturally adaptive ways of transacting, teachers can provide opportunities for their students to generate positive emotional energy and group solidarity in the learning of science at an informal science center.

  6. Outbursts formation on low carbon and trip steel grades during hot-dip galvanisation

    NASA Astrophysics Data System (ADS)

    Petit, E. J.; Lamm, L.; Gilles, M.

    2004-12-01

    Low carbon and TRIP grade steels have been hot dip galvanised in order to study outbursts formation. Microstructure and texture of intermetallic phases have been observed after selective electrochemical etching by scanning electron microscopy. Potential versus time (chronopotentiometric) characteristics were recorded in order to monitor surface modifications. This combination of techniques enable to quantify and observe intermetallic phase one by one. The overall thickness of coating on both substrates are similar. However, microstructures of Fe-Zn intermetallic phases are very different on both grades. In particular, the V phase is dense on standard steel but develops a highly branched filament structure on TRIP steel. The transformation of V phase to d and G1 are limited on TRIP steel. Differences of texture provide clues for understanding mechanisms of formation of outbursts. They can account for the differences of mechanical properties and corrosion resistance. Silicon from the substrate influences the reactivity of TRIP steels due to capping and local reactions. La formation des outbursts a été étudiée sur un acier bas carbone et sur un acier TRIP galvanisés. Les épaisseurs des revêtements sont similaires. Néanmoins, les observations microscopiques et les érosions électrochimiques montrent que la répartition des phases intermétalliques et leurs microstructures diffèrent sensiblement en fonction de la nature du substrat. Ces différences expliquent les propriétés mécaniques et anticorrosions. L’encapsulation de la surface par les oxydes de silicium freine la transformation de la phase dzêta en delta et gamma sur l’acier TRIP.

  7. Fluorescence Visualization of Hypersonic Flow Past Triangular and Rectangular Boundary-layer Trips

    NASA Technical Reports Server (NTRS)

    Danehy, Paul M.; Garcia, A. P.; Borg, Stephen E.; Dyakonov, Artem A.; Berry, Scott A.; Inman, Jennifer A.; Alderfer, David W.

    2007-01-01

    Planar laser-induced fluorescence (PLIF) flow visualization has been used to investigate the hypersonic flow of air over surface protrusions that are sized to force laminar-to-turbulent boundary layer transition. These trips were selected to simulate protruding Space Shuttle Orbiter heat shield gap-filler material. Experiments were performed in the NASA Langley Research Center 31-Inch Mach 10 Air Wind Tunnel, which is an electrically-heated, blowdown facility. Two-mm high by 8-mm wide triangular and rectangular trips were attached to a flat plate and were oriented at an angle of 45 degrees with respect to the oncoming flow. Upstream of these trips, nitric oxide (NO) was seeded into the boundary layer. PLIF visualization of this NO allowed observation of both laminar and turbulent boundary layer flow downstream of the trips for varying flow conditions as the flat plate angle of attack was varied. By varying the angle of attack, the Mach number above the boundary layer was varied between 4.2 and 9.8, according to analytical oblique-shock calculations. Computational Fluid Dynamics (CFD) simulations of the flowfield with a laminar boundary layer were also performed to better understand the flow environment. The PLIF images of the tripped boundary layer flow were compared to a case with no trip for which the flow remained laminar over the entire angle-of-attack range studied. Qualitative agreement is found between the present observed transition measurements and a previous experimental roughness-induced transition database determined by other means, which is used by the shuttle return-to-flight program.

  8. Career-Focused Field Trips as Experienced by At-Risk Rural Students: A Case Study

    ERIC Educational Resources Information Center

    Hutson, Tommye L.

    2010-01-01

    A lack of recent research focused on field trips as pedagogy in K-12 settings established the foundation for this work. The research design followed multiple-case case study model. The participants were four male students from a small rural high school in central Texas. Each participant, previously labeled as academically "at-risk", had…

  9. Utilizing Geo-Referenced Mobile Game Technology for Universally Accessible Virtual Geology Field Trips

    ERIC Educational Resources Information Center

    Bursztyn, Natalie; Pederson, Joel; Shelton, Brett; Walker, Andrew; Campbell, Todd

    2015-01-01

    Declining interest and low persistence is well documented among undergraduate students in Science, Technology, Engineering, and Math in the United States. For geoscience, field trips are important attractors to students, however with high enrollment courses and increasing costs they are becoming rare. We propose in this concept paper that the…

  10. A Trip to the Statler Hilton Hotel. The Special Education Curriculum Series.

    ERIC Educational Resources Information Center

    Kendall, Muriel

    A program designed for high school level work-study classes for students of limited mental ability presents specific curriculum methods and materials to teach information regarding positions available in the hotel industry. A field trip tour of the Boston Statler Hilton Hotel if the focal activity of the unit, and is accompanied by a history of…

  11. Scalable Performance Measurement and Analysis

    SciTech Connect

    Gamblin, Todd

    2009-01-01

    Concurrency levels in large-scale, distributed-memory supercomputers are rising exponentially. Modern machines may contain 100,000 or more microprocessor cores, and the largest of these, IBM's Blue Gene/L, contains over 200,000 cores. Future systems are expected to support millions of concurrent tasks. In this dissertation, we focus on efficient techniques for measuring and analyzing the performance of applications running on very large parallel machines. Tuning the performance of large-scale applications can be a subtle and time-consuming task because application developers must measure and interpret data from many independent processes. While the volume of the raw data scales linearly with the number of tasks in the running system, the number of tasks is growing exponentially, and data for even small systems quickly becomes unmanageable. Transporting performance data from so many processes over a network can perturb application performance and make measurements inaccurate, and storing such data would require a prohibitive amount of space. Moreover, even if it were stored, analyzing the data would be extremely time-consuming. In this dissertation, we present novel methods for reducing performance data volume. The first draws on multi-scale wavelet techniques from signal processing to compress systemwide, time-varying load-balance data. The second uses statistical sampling to select a small subset of running processes to generate low-volume traces. A third approach combines sampling and wavelet compression to stratify performance data adaptively at run-time and to reduce further the cost of sampled tracing. We have integrated these approaches into Libra, a toolset for scalable load-balance analysis. We present Libra and show how it can be used to analyze data from large scientific applications scalably.

  12. INSTRUCTIONAL TRIPS, A PROGRAM FOR ENRICHING EDUCATIONAL EXPERIENCE IN THE ELEMENTARY SCHOOLS.

    ERIC Educational Resources Information Center

    FINK, ALLAN; AND OTHERS

    A TEACHER GUIDE FOR FIELD TRIPS IN THE PASADENA, CALIFORNIA, AREA IS PRESENTED. EACH TRIP SHOULD BE PRECEDED BY AN EXPLANATION OF THE PURPOSES OF THE TRIP IN RELATION TO PRESENT COURSE OF STUDY. AS A FOLLOWUP ACTIVITY, DISCUSSION OF IDEAS GAINED DURING THE TRIP SHOULD BE ENCOURAGED. THE RULES, REGULATIONS AND PROCEDURES OF THE TRIP ARE GIVEN. TRIP…

  13. A scalable parallel open architecture data acquisition system for low to high rate experiments, test beams and all SSC (Superconducting Super Collider) detectors

    SciTech Connect

    Barsotti, E.; Booth, A.; Bowden, M.; Swoboda, C. ); Lockyer, N.; VanBerg, R. )

    1989-12-01

    A new era of high-energy physics research is beginning requiring accelerators with much higher luminosities and interaction rates in order to discover new elementary particles. As a consequences, both orders of magnitude higher data rates from the detector and online processing power, well beyond the capabilities of current high energy physics data acquisition systems, are required. This paper describes a new data acquisition system architecture which draws heavily from the communications industry, is totally parallel (i.e., without any bottlenecks), is capable of data rates of hundreds of GigaBytes per second from the detector and into an array of online processors (i.e., processor farm), and uses an open systems architecture to guarantee compatibility with future commercially available online processor farms. The main features of the system architecture are standard interface ICs to detector subsystems wherever possible, fiber optic digital data transmission from the near-detector electronics, a self-routing parallel event builder, and the use of industry-supported and high-level language programmable processors in the proposed BCD system for both triggers and online filters. A brief status report of an ongoing project at Fermilab to build the self-routing parallel event builder will also be given in the paper. 3 figs., 1 tab.

  14. Geology and coastal hazards in the northern Monterey Bay, California: field trip guidebook, November 4, 2000

    USGS Publications Warehouse

    Hapke, Cheryl

    2000-01-01

    The purpose of this field trip is to explore the relationships between local geology, coastal hazards, and human influences in the northern Monterey Bay, which is a tectonically active high wave energy coastal environment. Seacliffs, shore platforms, pocket beaches and a headland/embayment morphology characterize this rocky coastline. Many studies of the onshore and offshore geology and geophysics, the local wave climate, and the effects of large storm events and earthquakes on the coastline have been conducted in this region (see Related Reading section). This field trip summarizes many of the findings of these research investigations, and also considers the relationship between the rates and styles of seacliff erosion and the variations in the local geology. The field trip stops allow the participant to examine seacliff sites of different geological lithologies, geographic orientations, and varying protection from wave attack, and consider how these variables affect not only the rate or magnitude of seacliff retreat but also the styles of retreat. In general the two primary forcing factors in the retreat of seacliffs are marine and terrestrial processes. At the various field trip stops, the relative importance of these processes in shaping the coastline at that particular location will be explored. Where beaches have developed, whether naturally or by emplacement of man-made structures, field trip stops are designed to look at the occurrence of the beaches (why they exist where they do) and to understand the response of the beaches to large storm events. Finally, this trip focuses on the various coastline protection structures that have been built in the area, and their effectiveness in protecting development on the beaches or at the tops of the seacliffs. The first stop of the trip is the Long Marine Lab facility where the seacliffs are composed of the most resistant geological unit in the area, the Miocene Santa Cruz Mudstone. This stop also includes discussion

  15. SWIFT-scalable clustering for automated identification of rare cell populations in large, high-dimensional flow cytometry datasets, part 2: biological evaluation.

    PubMed

    Mosmann, Tim R; Naim, Iftekhar; Rebhahn, Jonathan; Datta, Suprakash; Cavenaugh, James S; Weaver, Jason M; Sharma, Gaurav

    2014-05-01

    A multistage clustering and data processing method, SWIFT (detailed in a companion manuscript), has been developed to detect rare subpopulations in large, high-dimensional flow cytometry datasets. An iterative sampling procedure initially fits the data to multidimensional Gaussian distributions, then splitting and merging stages use a criterion of unimodality to optimize the detection of rare subpopulations, to converge on a consistent cluster number, and to describe non-Gaussian distributions. Probabilistic assignment of cells to clusters, visualization, and manipulation of clusters by their cluster medians, facilitate application of expert knowledge using standard flow cytometry programs. The dual problems of rigorously comparing similar complex samples, and enumerating absent or very rare cell subpopulations in negative controls, were solved by assigning cells in multiple samples to a cluster template derived from a single or combined sample. Comparison of antigen-stimulated and control human peripheral blood cell samples demonstrated that SWIFT could identify biologically significant subpopulations, such as rare cytokine-producing influenza-specific T cells. A sensitivity of better than one part per million was attained in very large samples. Results were highly consistent on biological replicates, yet the analysis was sensitive enough to show that multiple samples from the same subject were more similar than samples from different subjects. A companion manuscript (Part 1) details the algorithmic development of SWIFT.

  16. Development of a rapid high-efficiency scalable process for acetylated Sus scrofa cationic trypsin production from Escherichia coli inclusion bodies.

    PubMed

    Zhao, Mingzhi; Wu, Feilin; Xu, Ping

    2015-12-01

    Trypsin is one of the most important enzymatic tools in proteomics and biopharmaceutical studies. Here, we describe the complete recombinant expression and purification from a trypsinogen expression vector construct. The Sus scrofa cationic trypsin gene with a propeptide sequence was optimized according to Escherichia coli codon-usage bias and chemically synthesized. The gene was inserted into pET-11c plasmid to yield an expression vector. Using high-density E. coli fed-batch fermentation, trypsinogen was expressed in inclusion bodies at 1.47 g/L. The inclusion body was refolded with a high yield of 36%. The purified trypsinogen was then activated to produce trypsin. To address stability problems, the trypsin thus produced was acetylated. The final product was generated upon gel filtration. The final yield of acetylated trypsin was 182 mg/L from a 5-L fermenter. Our acetylated trypsin product demonstrated higher BAEE activity (30,100 BAEE unit/mg) than a commercial product (9500 BAEE unit/mg, Promega). It also demonstrated resistance to autolysis. This is the first report of production of acetylated recombinant trypsin that is stable and suitable for scale-up.

  17. Scalable complexity-distortion model for fast motion estimation

    NASA Astrophysics Data System (ADS)

    Yi, Xiaoquan; Ling, Nam

    2005-07-01

    Recently established international video coding standard H.264/AVC and the upcoming standard on scalable video coding (SVC) bring part of the solution to high compression ratio requirement and heterogeneity requirement. However, these algorithms have unbearable complexities for real-time encoding. Therefore, there is an important challenge to reduce encoding complexity, preferably in a scalable manner. Motion estimation and motion compensation techniques provide significant coding gain but are the most time-intensive parts in an encoder system. They present tremendous research challenges to design a flexible, rate-distortion optimized, yet computationally efficient encoder, especially for various applications. In this paper, we present a scalable motion estimation framework for complexitydistortion consideration. We propose a new progressive initial search (PIS) method to generate an accurate initial search point, followed by a fast search method, which can greatly benefit from the tighter bounds of the PIS. Such approach offers not only significant speedup but also an optimal distortion performance for a given complexity constrain. We analyze the relationship between computational complexity and distortion (C-D) through probabilistic distance measure extending from the complexity and distortion theory. A configurable complexity quantization parameter (Q) is introduced. Simulation results demonstrate that the proposed scalable complexity-distortion framework enables video encoder to conveniently adjust its complexity while providing best possible services.

  18. Scalable High-Performance Algorithm for the Simulation of Exciton Dynamics. Application to the Light-Harvesting Complex II in the Presence of Resonant Vibrational Modes.

    PubMed

    Kreisbeck, Christoph; Kramer, Tobias; Aspuru-Guzik, Alán

    2014-09-09

    The accurate simulation of excitonic energy transfer in molecular complexes with coupled electronic and vibrational degrees of freedom is essential for comparing excitonic system parameters obtained from ab initio methods with measured time-resolved spectra. Several exact methods for computing the exciton dynamics within a density-matrix formalism are known but are restricted to small systems with less than 10 sites due to their computational complexity. To study the excitonic energy transfer in larger systems, we adapt and extend the exact hierarchical equation of motion (HEOM) method to various high-performance many-core platforms using the Open Compute Language (OpenCL). For the light-harvesting complex II (LHC II) found in spinach, the HEOM results deviate from predictions of approximate theories and clarify the time scale of the transfer process. We investigate the impact of resonantly coupled vibrations on the relaxation and show that the transfer does not rely on a fine-tuning of specific modes.

  19. Managing Health and Safety on International School Trips

    ERIC Educational Resources Information Center

    Hunter-Jones, John; Hunter-Jones, Philippa

    2007-01-01

    Organizing international school trips can be a demanding experience because of the age of the participants, the unfamiliar surroundings and the excitement associated with the foreign trip. As many organizers are full-time teachers, without a background in the travel sector, the pressures can be even greater. The need to anticipate potential risks…

  20. Should You Rule Out Fund Raising, Trips, and Contests?

    ERIC Educational Resources Information Center

    Ross, Stewart L.

    1992-01-01

    Schools need not rule out fund raising, trips, and contests. Well-organized groups of music students washing cars at local gas stations can create more positive publicity and goodwill toward music programs than can hundreds of news releases. Exchange concerts, trips to nearby schools, and competition against a predetermined scale can substitute…

  1. Off-Site Trip Leaders: Selecting Appropriate Staff.

    ERIC Educational Resources Information Center

    Evans, Will

    1996-01-01

    Well-trained off-site trip leaders can turn a trip into a positive educational lesson. American Camping Association standards are referenced, and some personality traits are suggested as criteria for determining the suitability of staff to act responsibly "in loco director." Discusses factors that determine counselor-to-camper ratios,…

  2. Slip, Trip, and Fall Injuries Among Nursing Care Facility Workers

    PubMed Central

    Bell, Jennifer L.; Collins, James W.; Tiesman, Hope M.; Ridenour, Marilyn; Konda, Srinivas; Wolf, Laurie; Evanoff, Bradley

    2015-01-01

    The objective of this research was to describe the slip, trip, and fall injury experience and trends in a population of nursing home workers, identify risk factors for slip, trip, and fall injuries, and develop prevention strategies for slip, trip, and fall hazards. Workers’ compensation injury claims data and payroll data from 1996 through 2003 were obtained from six nursing homes and used to calculate injury incidence rates. Narrative information was used to describe details of slip, trip, and fall events. A total of 86 slip, trip, and fall-related workers’ compensation claims were filed during the 8-year period. Slip, trip, and fall claim rates showed a nonsignificant increase during the 8-year period. Most slips, trips, and falls were attributed to hazards that can be mitigated (e.g., water on the floor or loose cords in a walkway). Nursing home workers experience more slip, trip, and fall-related injury claims than workers in other industries. Preventive programs should be implemented and evaluated in this industry. PMID:23521142

  3. Development of Teacher Attitude Scale towards the Field Trip

    ERIC Educational Resources Information Center

    Tortop, Hasan Said

    2012-01-01

    A field trip is an excursion by group of students with teachers to a place away from classroom such as natural field, science center, and zoo. So, it is an important tool for renewable energy education. This study was carried out to develop a new scale for measuring teacher attitudes towards the field trip. Teacher attitude scale towards the field…

  4. Psychological Sense of Community and Group Cohesion on Wilderness Trips

    ERIC Educational Resources Information Center

    Breunig, Mary; O'Connell, Tim; Todd, Sharon; Young, Anderson; Anderson, Lynn; Anderson, Dale

    2008-01-01

    A primary purpose of many wilderness trip programs is the development of positive interpersonal relationships and group experiences that lead to enhanced sense of community among group members. Although there is anecdotal evidence to support the development of sense of community on wilderness trips, there is little empirical evidence to support…

  5. Elementary school children's science learning from school field trips

    NASA Astrophysics Data System (ADS)

    Glick, Marilyn Petty

    This research examines the impact of classroom anchoring activities on elementary school students' science learning from a school field trip. Although there is prior research demonstrating that students can learn science from school field trips, most of this research is descriptive in nature and does not examine the conditions that enhance or facilitate such learning. The current study draws upon research in psychology and education to create an intervention that is designed to enhance what students learn from school science field trips. The intervention comprises of a set of "anchoring" activities that include: (1) Orientation to context, (2) Discussion to activate prior knowledge and generate questions, (3) Use of field notebooks during the field trip to record observations and answer questions generated prior to field trip, (4) Post-visit discussion of what was learned. The effects of the intervention are examined by comparing two groups of students: an intervention group which receives anchoring classroom activities related to their field trip and an equivalent control group which visits the same field trip site for the same duration but does not receive any anchoring classroom activities. Learning of target concepts in both groups was compared using objective pre and posttests. Additionally, a subset of students in each group were interviewed to obtain more detailed descriptive data on what children learned through their field trip.

  6. Collecting Planarians: A Good Choice for a Field Trip.

    ERIC Educational Resources Information Center

    Cha, Heeyoung

    2001-01-01

    Describes a field trip to collect planarians as successful in generating interest in the sciences. This activity is suitable for all grade levels as a field trip or biology lab. Planarians can be easily collected from streams across the United States. Once in the classroom, planaria are easily fed and cared for. (SAH)

  7. In Praise of Off-Season Field Trips. Comments.

    ERIC Educational Resources Information Center

    Butler, David R.; Wilkerson, Forrest D.

    2000-01-01

    Discusses university field courses and field trips. Offers alternatives to summer fieldwork, describing college-level field trips during spring, autumn, and winter. Concludes that the fun of fieldwork is essential and that a dialogue should occur between university instructors and K-12 teachers. (CMK)

  8. The Beginner's Guide to Interactive Virtual Field Trips

    ERIC Educational Resources Information Center

    Zanetis, Jan

    2010-01-01

    For students, field trips can be the best of both worlds: a welcome and exciting break from day-to-day classroom activities and a memorable, real-world experience that will solidify the curriculum in their minds. Unfortunately, the most desirable trips--those to far-away, enticing destinations--have long been inaccessible to all but a select few,…

  9. Toward a Virtual Field Trip Model for the Social Studies

    ERIC Educational Resources Information Center

    Stoddard, Jeremy

    2009-01-01

    In the current state of social studies education, field trips are being cut from many schools' curriculum. While not a true substitution, today's technologies provide some opportunities through virtual field trips (VFTs) to simulate these experiences, engage students in knowledge production and disciplined inquiry, and have interactions with the…

  10. Strategies for Planning an Overseas Field Trip for Young Athletes

    ERIC Educational Resources Information Center

    Hubball, Harry; Robertson, Scott

    2004-01-01

    Overseas field trips, when they are well planned, offer numerous benefits to young athletes. They contribute to player development, and fuel the team's energy and commitment to success. Field trips are enjoyable and exciting breaks from the regular routine of training and competing. The authors recommend strategies for positive results based on…

  11. Mechanisms Influencing Student Understanding on an Outdoor Guided Field Trip

    ERIC Educational Resources Information Center

    Caskey, Nourah Al-Rashid

    2009-01-01

    Field trips are a basic and important, yet often overlooked part of the student experience. They provide the opportunity to integrate real world knowledge with classroom learning and student previous personal experiences. Outdoor guided field trips leave students with an increased understanding, awareness and interest and in science. However, the…

  12. Effectiveness of Field Trips in Teaching Groundwater Concepts.

    ERIC Educational Resources Information Center

    Pederson, Darryll T.

    1979-01-01

    The field trip procedures described were devised for use with freshman college students as an alternative to a classroom or laboratory session. Pre-test and post-test of students' knowledge of groundwater concepts show significant change in students' understanding of groundwater occurance and movement following such a trip. (RE)

  13. Scalable synthesis of core-shell structured SiOx/nitrogen-doped carbon composite as a high-performance anode material for lithium-ion batteries

    NASA Astrophysics Data System (ADS)

    Shi, Lu; Wang, Weikun; Wang, Anbang; Yuan, Keguo; Jin, Zhaoqing; Yang, Yusheng

    2016-06-01

    In this work, a novel core-shell structured SiOx/nitrogen-doped carbon composite has been prepared by simply dispersing the SiOx particles, which are synthesized by a thermal evaporation method from an equimolar mixture of Si and SiO2, into the dopamine solution, followed by a carbonization process. The SiOx core is well covered by the conformal and homogeneous nitrogen-doped carbon layer from the pyrolysis of polydopamine. By contrast with the bare SiOx, the electrochemical performance of the as-prepared core-shell structured SiOx/nitrogen-doped carbon composite has been improved significantly. It delivers a reversible capacity of 1514 mA h g-1 after 100 cycles at a current density of 100 mA g-1 and 933 mA h g-1 at 2 A g-1, much higher than those of commercial graphite anodes. The nitrogen-doped carbon layer ensures the excellent electrochemical performance of the SiOx/C composite. In addition, since dopamine can self-polymerize and coat virtually any surface, this versatile, facile and highly efficient coating process may be widely applicable to obtain various composites with uniform nitrogen-doped carbon coating layer.

  14. Sustainable Engineering and Improved Recycling of PET for High-Value Applications: Transforming Linear PET to Lightly Branched PET with a Novel, Scalable Process

    NASA Astrophysics Data System (ADS)

    Pierre, Cynthia; Torkelson, John

    2009-03-01

    A major challenge for the most effective recycling of poly(ethylene terephthalate) concerns the fact that initial melt processing of PET into a product leads to substantial degradation of molecular weight. Thus, recycled PET has insufficient melt viscosity for reuse in high-value applications such as melt-blowing of PET bottles. Academic and industrial research has tried to remedy this situation by synthesis and use of ``chain extenders'' that can lead to branched PET (with higher melt viscosity than the linear recycled PET) via condensation reactions with functional groups on the PET. Here we show that simple processing of PET via solid-state shear pulverization (SSSP) leads to enhanced PET melt viscosity without need for chemical additives. We hypothesize that this branching results from low levels of chain scission accompanying SSSP, leading to formation of polymeric radicals that participate in chain transfer and combination reactions with other PET chains and thereby to in situ branch formation. The pulverized PET exhibits vastly enhanced crystallization kinetics, eliminating the need to employ cold crystallization to achieve maximum PET crystallinity. Results of SSSP processing of PET will be compared to results obtained with poly(butylene terephthalate).

  15. Microprocessor tester for the treat upgrade reactor trip system

    SciTech Connect

    Lenkszus, F.R.; Bucher, R.G.

    1984-01-01

    The upgrading of the Transient Reactor Test (TREAT) Facility at ANL-Idaho has been designed to provide additional experimental capabilities for the study of core disruptive accident (CDA) phenomena. In addition, a programmable Automated Reactor Control System (ARCS) will permit high-power transients up to 11,000 MW having a controlled reactor period of from 15 to 0.1 sec. These modifications to the core neutronics will improve simulation of LMFBR accident conditions. Finally, a sophisticated, multiply-redundant safety system, the Reactor Trip System (RTS), will provide safe operation for both steady state and transient production operating modes. To insure that this complex safety system is functioning properly, a Dedicated Microprocessor Tester (DMT) has been implemented to perform a thorough checkout of the RTS prior to all TREAT operations.

  16. Evaluation of in-situ deformation experiments of TRIP steel

    NASA Astrophysics Data System (ADS)

    Procházka, J.; Kučerová, L.; Bystrianský, M.

    2017-02-01

    The paper reports on the behaviour of low alloyed TRIP (transformation induced plasticity) steel with Niobium during tensile test. The structures were analysed using in-situ tensile testing coupled with electron backscattering diffraction (EBSD) analysis carried out in scanning electron microscope (SEM). Steel specimens were of same chemical composition; however three different annealing temperatures, 800 °C, 850 °C and 950 °C, were applied to the material during the heat treatment. The treatment consisted of annealing for 20 minutes in the furnace; cooling in salt bath after the heating and holding at 425 °C for 20 minutes for all the samples. Untreated bar was used as reference material. Flat samples for deformation stage were cut out of the heat-treated bars. In situ documentation of microstructure and crystallography development were carried out during the deformation experiments. High deformation lead to significant degradation of EBSD signal.

  17. Scalable Video Transcaling for the Wireless Internet

    NASA Astrophysics Data System (ADS)

    Radha, Hayder; van der Schaar, Mihaela; Karande, Shirish

    2004-12-01

    The rapid and unprecedented increase in the heterogeneity of multimedia networks and devices emphasizes the need for scalable and adaptive video solutions both for coding and transmission purposes. However, in general, there is an inherent trade-off between the level of scalability and the quality of scalable video streams. In other words, the higher the bandwidth variation, the lower the overall video quality of the scalable stream that is needed to support the desired bandwidth range. In this paper, we introduce the notion of wireless video transcaling (TS), which is a generalization of (nonscalable) transcoding. With TS, a scalable video stream, that covers a given bandwidth range, is mapped into one or more scalable video streams covering different bandwidth ranges. Our proposed TS framework exploits the fact that the level of heterogeneity changes at different points of the video distribution tree over wireless and mobile Internet networks. This provides the opportunity to improve the video quality by performing the appropriate TS process. We argue that an Internet/wireless network gateway represents a good candidate for performing TS. Moreover, we describe hierarchical TS (HTS), which provides a "transcaler" with the option of choosing among different levels of TS processes with different complexities. We illustrate the benefits of TS by considering the recently developed MPEG-4 fine granularity scalability (FGS) video coding. Extensive simulation results of video TS over bit rate ranges supported by emerging wireless LANs are presented.

  18. Fully scalable video coding with packed stream

    NASA Astrophysics Data System (ADS)

    Lopez, Manuel F.; Rodriguez, Sebastian G.; Ortiz, Juan Pablo; Dana, Jose Miguel; Ruiz, Vicente G.; Garcia, Inmaculada

    2005-03-01

    Scalable video coding is a technique which allows a compressed video stream to be decoded in several different ways. This ability allows a user to adaptively recover a specific version of a video depending on its own requirements. Video sequences have temporal, spatial and quality scalabilities. In this work we introduce a novel fully scalable video codec. It is based on a motion-compensated temporal filtering (MCTF) of the video sequences and it uses some of the basic elements of JPEG 2000. This paper describes several specific proposals for video on demand and video-conferencing applications over non-reliable packet-switching data networks.

  19. Scalable encryption using alpha rooting

    NASA Astrophysics Data System (ADS)

    Wharton, Eric J.; Panetta, Karen A.; Agaian, Sos S.

    2008-04-01

    Full and partial encryption methods are important for subscription based content providers, such as internet and cable TV pay channels. Providers need to be able to protect their products while at the same time being able to provide demonstrations to attract new customers without giving away the full value of the content. If an algorithm were introduced which could provide any level of full or partial encryption in a fast and cost effective manner, the applications to real-time commercial implementation would be numerous. In this paper, we present a novel application of alpha rooting, using it to achieve fast and straightforward scalable encryption with a single algorithm. We further present use of the measure of enhancement, the Logarithmic AME, to select optimal parameters for the partial encryption. When parameters are selected using the measure, the output image achieves a balance between protecting the important data in the image while still containing a good overall representation of the image. We will show results for this encryption method on a number of images, using histograms to evaluate the effectiveness of the encryption.

  20. Design and Implementation of a Genomics Field Trip Program Aimed at Secondary School Students

    PubMed Central

    Fox, Joanne A.

    2012-01-01

    With the rapid pace of advancements in biological research brought about by the application of computer science and information technology, we believe the time is right for introducing genomics and bioinformatics tools and concepts to secondary school students. Our approach has been to offer a full-day field trip in our research facility where secondary school students carry out experiments at the laboratory bench and on a laptop computer. This experience offers benefits for students, teachers, and field trip instructors. In delivering a wide variety of science outreach and education programs, we have learned that a number of factors contribute to designing a successful experience for secondary school students. First, it is important to engage students with authentic and fun activities that are linked to real-world applications and/or research questions. Second, connecting with a local high school teacher to pilot programs and linking to curricula taught in secondary schools will enrich the field trip experience. Whether or not programs are linked directly to local teachers, it is important to be flexible and build in mechanisms for collecting feedback in field trip programs. Finally, graduate students can be very powerful mentors for students and should be encouraged to share their enthusiasm for science and to talk about career paths. Our experiences suggest a real need for effective science outreach programs at the secondary school level and that genomics and bioinformatics are ideal areas to explore. PMID:22956895

  1. Generic algorithms for high performance scalable geocomputing

    NASA Astrophysics Data System (ADS)

    de Jong, Kor; Schmitz, Oliver; Karssenberg, Derek

    2016-04-01

    During the last decade, the characteristics of computing hardware have changed a lot. For example, instead of a single general purpose CPU core, personal computers nowadays contain multiple cores per CPU and often general purpose accelerators, like GPUs. Additionally, compute nodes are often grouped together to form clusters or a supercomputer, providing enormous amounts of compute power. For existing earth simulation models to be able to use modern hardware platforms, their compute intensive parts must be rewritten. This can be a major undertaking and may involve many technical challenges. Compute tasks must be distributed over CPU cores, offloaded to hardware accelerators, or distributed to different compute nodes. And ideally, all of this should be done in such a way that the compute task scales well with the hardware resources. This presents two challenges: 1) how to make good use of all the compute resources and 2) how to make these compute resources available for developers of simulation models, who may not (want to) have the required technical background for distributing compute tasks. The first challenge requires the use of specialized technology (e.g.: threads, OpenMP, MPI, OpenCL, CUDA). The second challenge requires the abstraction of the logic handling the distribution of compute tasks from the model-specific logic, hiding the technical details from the model developer. To assist the model developer, we are developing a C++ software library (called Fern) containing algorithms that can use all CPU cores available in a single compute node (distributing tasks over multiple compute nodes will be done at a later stage). The algorithms are grid-based (finite difference) and include local and spatial operations such as convolution filters. The algorithms handle distribution of the compute tasks to CPU cores internally. In the resulting model the low-level details of how this is done is separated from the model-specific logic representing the modeled system. This contrasts with practices in which code for distributing of compute tasks is mixed with model-specific code, and results in a better maintainable model. For flexibility and efficiency, the algorithms are configurable at compile-time with the respect to the following aspects: data type, value type, no-data handling, input value domain handling, and output value range handling. This makes the algorithms usable in very different contexts, without the need for making intrusive changes to existing models when using them. Applications that benefit from using the Fern library include the construction of forward simulation models in (global) hydrology (e.g. PCR-GLOBWB (Van Beek et al. 2011)), ecology, geomorphology, or land use change (e.g. PLUC (Verstegen et al. 2014)) and manipulation of hyper-resolution land surface data such as digital elevation models and remote sensing data. Using the Fern library, we have also created an add-on to the PCRaster Python Framework (Karssenberg et al. 2010) allowing its users to speed up their spatio-temporal models, sometimes by changing just a single line of Python code in their model. In our presentation we will give an overview of the design of the algorithms, providing examples of different contexts where they can be used to replace existing sequential algorithms, including the PCRaster environmental modeling software (www.pcraster.eu). We will show how the algorithms can be configured to behave differently when necessary. References Karssenberg, D., Schmitz, O., Salamon, P., De Jong, K. and Bierkens, M.F.P., 2010, A software framework for construction of process-based stochastic spatio-temporal models and data assimilation. Environmental Modelling & Software, 25, pp. 489-502, Link. Best Paper Award 2010: Software and Decision Support. Van Beek, L. P. H., Y. Wada, and M. F. P. Bierkens. 2011. Global monthly water stress: 1. Water balance and water availability. Water Resources Research. 47. Verstegen, J. A., D. Karssenberg, F. van der Hilst, and A. P. C. Faaij. 2014. Identifying a land use change cellular automaton by Bayesian data assimilation. Environmental Modelling & Software 53:121-136.

  2. Efficient entropy coding for scalable video coding

    NASA Astrophysics Data System (ADS)

    Choi, Woong Il; Yang, Jungyoup; Jeon, Byeungwoo

    2005-10-01

    The standardization for the scalable extension of H.264 has called for additional functionality based on H.264 standard to support the combined spatio-temporal and SNR scalability. For the entropy coding of H.264 scalable extension, Context-based Adaptive Binary Arithmetic Coding (CABAC) scheme is considered so far. In this paper, we present a new context modeling scheme by using inter layer correlation between the syntax elements. As a result, it improves coding efficiency of entropy coding in H.264 scalable extension. In simulation results of applying the proposed scheme to encoding the syntax element mb_type, it is shown that improvement in coding efficiency of the proposed method is up to 16% in terms of bit saving due to estimation of more adequate probability model.

  3. The Co Design Architecture for Exascale Systems, a Novel Approach for Scalable Designs

    SciTech Connect

    Kagan, Michael; Shainer, Gilad; Poole, Stephen W; Shamis, Pavel; Wilde, Todd; Pak, Lui; Liu, Tong; Dubman, Mike; Shahar, Yiftah; Graham, Richard L

    2012-01-01

    High performance computing (HPC) has begun scaling beyond the Petaflop range towards the Exaflop (1000 Petaflops) mark. One of the major concerns throughout the development toward such performance capability is scalability both at the system level and the application layer. In this paper we present a novel approach for a new design concept the Co Design approach with enables a tighter development of both the application communication libraries and the underlying hardware interconnect solution in order to overcome scalability issues and to enable a more efficient design approach towards Exascale computing. We have suggested a new application programing interface and have demonstrated a 50x improvement of performance and scalability increases.

  4. Flow in Rotating Serpentine Coolant Passages With Skewed Trip Strips

    NASA Technical Reports Server (NTRS)

    Tse, David G.N.; Steuber, Gary

    1996-01-01

    Laser velocimetry was utilized to map the velocity field in serpentine turbine blade cooling passages with skewed trip strips. The measurements were obtained at Reynolds and Rotation numbers of 25,000 and 0.24 to assess the influence of trips, passage curvature and Coriolis force on the flow field. The interaction of the secondary flows induced by skewed trips with the passage rotation produces a swirling vortex and a corner recirculation zone. With trips skewed at +45 deg, the secondary flows remain unaltered as the cross-flow proceeds from the passage to the turn. However, the flow characteristics at these locations differ when trips are skewed at -45 deg. Changes in the flow structure are expected to augment heat transfer, in agreement with the heat transfer measurements of Johnson, et al. The present results show that trips are skewed at -45 deg in the outward flow passage and trips are skewed at +45 deg in the inward flow passage maximize heat transfer. Details of the present measurements were related to the heat transfer measurements of Johnson, et al. to relate fluid flow and heat transfer measurements.

  5. Student perspectives on their school trips to zoos

    NASA Astrophysics Data System (ADS)

    Davidson, Susan Kay

    This dissertation aimed to explore students' perspectives on their school trips to informal education sites. In particular, what did students think they learned, what did they want to do, what was fun or boring, and how did their trip relate to classroom activities? The two case studies presented here explore these ideas with 11-12-year olds in New Zealand and their class trips to zoos, in contrasting situations: one is a class in which the teacher thoughtfully and explicitly linked the trip to classroom learning both before and after the trip; the other classroom teacher did not. These differences impacted how students thought about their learning and how they valued the trip. Despite the differences, students had similarities in some of their perspectives, particularly in their focus on social interactions with peers and their desire to see the animals at the zoos. This study concludes with recommendations for informal and classroom educators, especially to find out what students are interested in, give them choices, and connect trips to classroom activities.

  6. Joint Experimentation on Scalable Parallel Processors (JESPP)

    DTIC Science & Technology

    2006-04-01

    SCALABLE PARALLEL PROCESSORS (JESPP) 6. AUTHOR(S) Dan M. Davis, Robert F. Lucas, Ke-Thia Yao, Gene Wagenbreth 5. FUNDING NUMBERS C...List of Papers • Robert J. Graebener, Gregory Rafuse, Robert Miller & Ke-Thia Yao, “The Road to Successful Joint Experimentation Starts at the...2003. • Robert F. Lucas & Dan M. Davis, “Joint Experimentation on Scalable Parallel Processors“, Interservice/Industry Training, Simulation, and

  7. Equalizer: a scalable parallel rendering framework.

    PubMed

    Eilemann, Stefan; Makhinya, Maxim; Pajarola, Renato

    2009-01-01

    Continuing improvements in CPU and GPU performances as well as increasing multi-core processor and cluster-based parallelism demand for flexible and scalable parallel rendering solutions that can exploit multipipe hardware accelerated graphics. In fact, to achieve interactive visualization, scalable rendering systems are essential to cope with the rapid growth of data sets. However, parallel rendering systems are non-trivial to develop and often only application specific implementations have been proposed. The task of developing a scalable parallel rendering framework is even more difficult if it should be generic to support various types of data and visualization applications, and at the same time work efficiently on a cluster with distributed graphics cards. In this paper we introduce a novel system called Equalizer, a toolkit for scalable parallel rendering based on OpenGL which provides an application programming interface (API) to develop scalable graphics applications for a wide range of systems ranging from large distributed visualization clusters and multi-processor multipipe graphics systems to single-processor single-pipe desktop machines. We describe the system architecture, the basic API, discuss its advantages over previous approaches, present example configurations and usage scenarios as well as scalability results.

  8. Efficient Byzantine Fault Tolerance for Scalable Storage and Services

    DTIC Science & Technology

    2009-07-01

    k O p s/ se c) No Redundancy Zzyzx-noPQ Zzyzx Zyzzyva (B=10) Zyzzyva (B=1) Zzyz x +f +1 Figure 5.5.6: Throughput vs. client processes when f = 1 and...28 ix x CONTENTS 3.4.4 Linearizability and Immediate Recovery...need only the minimal number of responsive servers to ensure high throughput, provide single roundtrip latency, and provide scalability through

  9. Scalable Advanced Network Services Based on Coordinated Active Components

    DTIC Science & Technology

    2004-02-01

    as a means of customizing both high functionality and scalable communication components to meet the needs of specific services. • A service...considering both the service quality for the user and the efficient use of the infrastructure (cost). ( 4 ) Finally, the synthesizer needs to configure the...response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed , and completing

  10. Scalable Anonymous Group Communication in the Anytrust Model

    DTIC Science & Technology

    2012-04-10

    nets messaging phase was high and not a significant improvement over the shuffle alone. Herbivore [31] makes low latency guar- antees (100s of...practical anonymity systems such as Tor [16] or Herbivore [31], where a small number of “wrong” choices—e.g., the choice of entry and exit relay in Tor—can...of-service attacks makes them largely impractical. Herbivore [31] attempts to make DC-nets more scalable, but it provides unconditional anonymity only

  11. Scalable Solutions for Interactive Virtual Humans that can Manipulate Objects

    DTIC Science & Technology

    2005-01-01

    A scalable approach is therefore sought for addressing such different requirements in an unified framework. Related Work Only few animation frameworks... animation of human grasping using forward and in- verse kinematics. Computer & Graphics 23:145–154. Baerlocher, P., and Boulic, R. 1998. Task-priority...formu- lations for the kinematic control of highly redundant artic - ulated structures. In Proceedings of IEEE IROS’98, 323– 329. Baerlocher, P. 2001

  12. Peer Pressure Road Trip 2012 - A Report

    NASA Astrophysics Data System (ADS)

    Popnoe, Olivia

    2012-10-01

    Each year since 2005 the Angelo State University SPS ``Peer Pressure Team'' has travelled for a week in May to promote physics and other sciences for grades K-12. This year, the Peer Pressure Team visited schools in West Texas and New Mexico. This was the first year the team has traveled outside of Texas, inspired by the SPS 2012 theme ``Physics Beyond Borders.'' The purpose of the Road Tours is to encourage an interest in science in children in grades K-12 and give experience in presenting and explaining physics to the undergraduate volunteers. The schools attended are carefully selected based on socioeconomic need and an underrepresentation in physics, as well as other sciences. During this week, the Peer Pressure Team saw about 1,500 students over 10 shows. Surveys were given to teachers post-demonstration to have students complete and return so the Team could gauge the effectiveness of the outreach program. In addition, the surveys allow the Team to determine which demonstrations had the most impact. We present the details of this year's road trip with the results and analysis of the survey data.

  13. You Can't Reach for the Stars if You are Tripping Over the Ground! (Preventing Slips, Trips, and Falls)

    NASA Technical Reports Server (NTRS)

    Miller, Darcy; Raysich, Mark; Kirkland, Mary

    2016-01-01

    Although there are very few mishaps related to ground, vehicle or payload processing at the Kennedy Space Center (KSC), employees have experienced a significant number of injuries due to slips, trips, and falls outside of performing flight processing operations. Slips, trips, and falls are major causes of occupational injuries at KSC, the National Aeronautics and Space Administration (NASA), and in general industry. To help KSC employees avoid these injuries, and allow them to be fully productive, KSC launched an initiative in 2013 to reduce slips, trips, and falls. This initiative is based on a four-part model focusing on DATA analysis, HAZARD awareness, PREVENTIVE methods, and BALANCE.

  14. Scalable parallel distance field construction for large-scale applications

    SciTech Connect

    Yu, Hongfeng; Xie, Jinrong; Ma, Kwan -Liu; Kolla, Hemanth; Chen, Jacqueline H.

    2015-10-01

    Computing distance fields is fundamental to many scientific and engineering applications. Distance fields can be used to direct analysis and reduce data. In this paper, we present a highly scalable method for computing 3D distance fields on massively parallel distributed-memory machines. Anew distributed spatial data structure, named parallel distance tree, is introduced to manage the level sets of data and facilitate surface tracking overtime, resulting in significantly reduced computation and communication costs for calculating the distance to the surface of interest from any spatial locations. Our method supports several data types and distance metrics from real-world applications. We demonstrate its efficiency and scalability on state-of-the-art supercomputers using both large-scale volume datasets and surface models. We also demonstrate in-situ distance field computation on dynamic turbulent flame surfaces for a petascale combustion simulation. In conclusion, our work greatly extends the usability of distance fields for demanding applications.

  15. Scalable Synthesis of Cortistatin A and Related Structures

    PubMed Central

    Shi, Jun; Manolikakes, Georg; Yeh, Chien-Hung; Guerrero, Carlos A.; Shenvi, Ryan A.; Shigehisa, Hiroki

    2011-01-01

    Full details are provided for an improved synthesis of cortistatin A and related structures as well as the underlying logic and evolution of strategy. The highly functionalized cortistatin A-ring embedded with a key heteroadamantane was synthesized by a simple and scalable 5-step sequence. A chemoselective, tandem geminal dihalogenation of an unactivated methyl group, a reductive fragmentation/trapping/elimination of a bromocyclopropane, and a facile chemoselective etherification reaction afforded the cortistatin A core, dubbed “cortistatinone”. A selective Δ16-alkene reduction with Raney Ni provided cortistatin A. With this scalable and practical route, copious quantities of cortistatinone, Δ16-cortistatin A-the equipotent direct precursor to cortistatin A, and its related analogs were prepared for further biological studies. PMID:21539314

  16. Scalable Quantum Photonics with Single Color Centers in Silicon Carbide.

    PubMed

    Radulaski, Marina; Widmann, Matthias; Niethammer, Matthias; Zhang, Jingyuan Linda; Lee, Sang-Yun; Rendler, Torsten; Lagoudakis, Konstantinos G; Son, Nguyen Tien; Janzén, Erik; Ohshima, Takeshi; Wrachtrup, Jörg; Vučković, Jelena

    2017-02-24

    Silicon carbide is a promising platform for single photon sources, quantum bits (qubits), and nanoscale sensors based on individual color centers. Toward this goal, we develop a scalable array of nanopillars incorporating single silicon vacancy centers in 4H-SiC, readily available for efficient interfacing with free-space objective and lensed-fibers. A commercially obtained substrate is irradiated with 2 MeV electron beams to create vacancies. Subsequent lithographic process forms 800 nm tall nanopillars with 400-1400 nm diameters. We obtain high collection efficiency of up to 22 kcounts/s optical saturation rates from a single silicon vacancy center while preserving the single photon emission and the optically induced electron-spin polarization properties. Our study demonstrates silicon carbide as a readily available platform for scalable quantum photonics architecture relying on single photon sources and qubits.

  17. Scalable, full-colour and controllable chromotropic plasmonic printing

    PubMed Central

    Xue, Jiancai; Zhou, Zhang-Kai; Wei, Zhiqiang; Su, Rongbin; Lai, Juan; Li, Juntao; Li, Chao; Zhang, Tengwei; Wang, Xue-Hua

    2015-01-01

    Plasmonic colour printing has drawn wide attention as a promising candidate for the next-generation colour-printing technology. However, an efficient approach to realize full colour and scalable fabrication is still lacking, which prevents plasmonic colour printing from practical applications. Here we present a scalable and full-colour plasmonic printing approach by combining conjugate twin-phase modulation with a plasmonic broadband absorber. More importantly, our approach also demonstrates controllable chromotropic capability, that is, the ability of reversible colour transformations. This chromotropic capability affords enormous potentials in building functionalized prints for anticounterfeiting, special label, and high-density data encryption storage. With such excellent performances in functional colour applications, this colour-printing approach could pave the way for plasmonic colour printing in real-world commercial utilization. PMID:26567803

  18. 18. Blacksmith Shop (first floor): view looking north; trip hammer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. Blacksmith Shop (first floor): view looking north; trip hammer and coal bin in background, shears and swage block in foreground - Ben Thresher's Mill, State Aid No. 1, Barnet, Caledonia County, VT

  19. 50 CFR 622.385 - Commercial trip limits.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE FISHERIES OF THE CARIBBEAN, GULF OF MEXICO, AND SOUTH ATLANTIC Coastal... a trip limit specified in this section taken in the EEZ may not be transferred at sea, regardless...

  20. Human round trip to Mars: Six months and radiation safe

    SciTech Connect

    Lazareth, O.W.; Schmidt, E.; Ludewig, H.; Powell, J.R.

    1991-01-01

    We describe a different type of round trip to Mars, using a combination of spacecraft. Compared to typical proposals, this flight is relatively fast and relatively safe from biological radiation dosage. Our study is concerned with the trip from Earth orbit to Mars orbit. Four spacecraft are required for the round trip. The crew spends most of their time on board a comparatively large, well shielded spacecraft (LC) which is in free (non-powered) orbit about the sun. The crew travels from Earth orbit to the LC while on board a comparatively small, powered spacecraft (SC). At Mars, the procedure is reversed and the crew returns on a second LC. In addition, a cargo craft, with no crew, is sent to Mars prior to the crew leaving Earth orbit. The trip time is about six months and the radiation dose equivalent is within guidelines recommended by the National Commission on Radiation Protection and Measurements.

  1. A Computational Investigation on Bending Deformation Behavior at Various Deflection Rates for Enhancement of Absorbable Energy in TRIP Steel

    NASA Astrophysics Data System (ADS)

    Pham, Hang Thi; Iwamoto, Takeshi

    2016-08-01

    Transformation-induced plasticity (TRIP) steel might have a high energy-absorption characteristic because it could possibly consume impact energy by not only plastic deformation but also strain-induced martensitic transformation (SIMT) during deformation. Therefore, TRIP steel is considered to be suitable for automotive structures from the viewpoint of safety. Bending deformation due to buckling is one of the major collapse modes of automotive structures. Thus, an investigation on the bending deformation behavior and energy-absorption characteristic in TRIP steel at high deformation rate is indispensable to clarify the mechanism of better performance. Some past studies have focused on the improvement of mechanical properties by means of SIMT; however, the mechanism through which the energy-absorption characteristic in steel can be improved is still unclear. In this study, the three-point bending deformation behavior of a beam specimen made of type-304 austenitic stainless steel, a kind of TRIP steel, is investigated at various deflection rates by experiments and finite-element simulations based on a constitutive model proposed by one of the authors. After confirming the validity of the computation, the rate-sensitivity of energy absorption from the viewpoint of hardening behavior is examined and the improvement of the energy-absorption characteristic in TRIP steel including its mechanism is discussed.

  2. Compressing Test and Evaluation by Using Flow Data for Scalable Network Traffic Analysis

    DTIC Science & Technology

    2014-10-01

    For example, low quality of service may be caused by many factors including high traffic volume (and associated congestion ), proximity of sender...Scalable Network Traffic Analysis 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER...by ANSI Std Z39-18 788Defense ARJ, October 2014, Vol. 21 No. 4 : 788–802 Compressing Test and Evaluation by Using Data for Scalable Network Traffic

  3. Observations on a Recent Trip to the Former Soviet Union

    DTIC Science & Technology

    1992-08-26

    NPS-NS-92-012 NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA AD-A255 891 J6 0- & R A D b OBSERVATIONS ON A RECENT TRIP TO THE FORMER SOVIET UNION BY...Include Security Classification) OBSERVATIONS ON A RECENT TRIP TO THE FORMER SOVIET UNION 12. PERSONAL AUTHOR(S) TRITTEN, JAMES JOHN 13a. TYPEOFREPORT...ABSTRACT (Continue on reverse if necessary and identify by block number) (8 A -C) ADDITIONAL SPONSOR, INTELLIGENCE PLANS & INTEGRATION DIRECTORATE

  4. Developing a scalable inert gas ion thruster

    NASA Technical Reports Server (NTRS)

    James, E.; Ramsey, W.; Steiner, G.

    1982-01-01

    Analytical studies to identify and then design a high performance scalable ion thruster operating with either argon or xenon for use in large space systems are presented. The magnetoelectrostatic containment concept is selected for its efficient ion generation capabilities. The iterative nature of the bounding magnetic fields allows the designer to scale both the diameter and length, so that the thruster can be adapted to spacecraft growth over time. Three different thruster assemblies (conical, hexagonal and hemispherical) are evaluated for a 12 cm diameter thruster and performance mapping of the various thruster configurations shows that conical discharge chambers produce the most efficient discharge operation, achieving argon efficiencies of 50-80% mass utilization at 240-310 eV/ion and xenon efficiencies of 60-97% at 240-280 eV/ion. Preliminary testing of the large 30 cm thruster, using argon propellant, indicates a 35% improvement over the 12 cm thruster in mass utilization efficiency. Since initial performance is found to be better than projected, a larger 50 cm thruster is already in the development stage.

  5. Lightweight and scalable secure communication in VANET

    NASA Astrophysics Data System (ADS)

    Zhu, Xiaoling; Lu, Yang; Zhu, Xiaojuan; Qiu, Shuwei

    2015-05-01

    To avoid a message to be tempered and forged in vehicular ad hoc network (VANET), the digital signature method is adopted by IEEE1609.2. However, the costs of the method are excessively high for large-scale networks. The paper efficiently copes with the issue with a secure communication framework by introducing some lightweight cryptography primitives. In our framework, point-to-point and broadcast communications for vehicle-to-infrastructure (V2I) and vehicle-to-vehicle (V2V) are studied, mainly based on symmetric cryptography. A new issue incurred is symmetric key management. Thus, we develop key distribution and agreement protocols for two-party key and group key under different environments, whether a road side unit (RSU) is deployed or not. The analysis shows that our protocols provide confidentiality, authentication, perfect forward secrecy, forward secrecy and backward secrecy. The proposed group key agreement protocol especially solves the key leak problem caused by members joining or leaving in existing key agreement protocols. Due to aggregated signature and substitution of XOR for point addition, the average computation and communication costs do not significantly increase with the increase in the number of vehicles; hence, our framework provides good scalability.

  6. A scalable neuristor built with Mott memristors

    NASA Astrophysics Data System (ADS)

    Pickett, Matthew D.; Medeiros-Ribeiro, Gilberto; Williams, R. Stanley

    2013-02-01

    The Hodgkin-Huxley model for action potential generation in biological axons is central for understanding the computational capability of the nervous system and emulating its functionality. Owing to the historical success of silicon complementary metal-oxide-semiconductors, spike-based computing is primarily confined to software simulations and specialized analogue metal-oxide-semiconductor field-effect transistor circuits. However, there is interest in constructing physical systems that emulate biological functionality more directly, with the goal of improving efficiency and scale. The neuristor was proposed as an electronic device with properties similar to the Hodgkin-Huxley axon, but previous implementations were not scalable. Here we demonstrate a neuristor built using two nanoscale Mott memristors, dynamical devices that exhibit transient memory and negative differential resistance arising from an insulating-to-conducting phase transition driven by Joule heating. This neuristor exhibits the important neural functions of all-or-nothing spiking with signal gain and diverse periodic spiking, using materials and structures that are amenable to extremely high-density integration with or without silicon transistors.

  7. Scalable Combinatorial Tools for Health Disparities Research

    PubMed Central

    Langston, Michael A.; Levine, Robert S.; Kilbourne, Barbara J.; Rogers, Gary L.; Kershenbaum, Anne D.; Baktash, Suzanne H.; Coughlin, Steven S.; Saxton, Arnold M.; Agboto, Vincent K.; Hood, Darryl B.; Litchveld, Maureen Y.; Oyana, Tonny J.; Matthews-Juarez, Patricia; Juarez, Paul D.

    2014-01-01

    Despite staggering investments made in unraveling the human genome, current estimates suggest that as much as 90% of the variance in cancer and chronic diseases can be attributed to factors outside an individual’s genetic endowment, particularly to environmental exposures experienced across his or her life course. New analytical approaches are clearly required as investigators turn to complicated systems theory and ecological, place-based and life-history perspectives in order to understand more clearly the relationships between social determinants, environmental exposures and health disparities. While traditional data analysis techniques remain foundational to health disparities research, they are easily overwhelmed by the ever-increasing size and heterogeneity of available data needed to illuminate latent gene x environment interactions. This has prompted the adaptation and application of scalable combinatorial methods, many from genome science research, to the study of population health. Most of these powerful tools are algorithmically sophisticated, highly automated and mathematically abstract. Their utility motivates the main theme of this paper, which is to describe real applications of innovative transdisciplinary models and analyses in an effort to help move the research community closer toward identifying the causal mechanisms and associated environmental contexts underlying health disparities. The public health exposome is used as a contemporary focus for addressing the complex nature of this subject. PMID:25310540

  8. Scalable cell alignment on optical media substrates.

    PubMed

    Anene-Nzelu, Chukwuemeka G; Choudhury, Deepak; Li, Huipeng; Fraiszudeen, Azmall; Peh, Kah-Yim; Toh, Yi-Chin; Ng, Sum Huan; Leo, Hwa Liang; Yu, Hanry

    2013-07-01

    Cell alignment by underlying topographical cues has been shown to affect important biological processes such as differentiation and functional maturation in vitro. However, the routine use of cell culture substrates with micro- or nano-topographies, such as grooves, is currently hampered by the high cost and specialized facilities required to produce these substrates. Here we present cost-effective commercially available optical media as substrates for aligning cells in culture. These optical media, including CD-R, DVD-R and optical grating, allow different cell types to attach and grow well on them. The physical dimension of the grooves in these optical media allowed cells to be aligned in confluent cell culture with maximal cell-cell interaction and these cell alignment affect the morphology and differentiation of cardiac (H9C2), skeletal muscle (C2C12) and neuronal (PC12) cell lines. The optical media is amenable to various chemical modifications with fibronectin, laminin and gelatin for culturing different cell types. These low-cost commercially available optical media can serve as scalable substrates for research or drug safety screening applications in industry scales.

  9. Language Travel or Language Tourism: Have Educational Trips Changed So Much?

    ERIC Educational Resources Information Center

    Laborda, Jesus Garcia

    2007-01-01

    This article points out the changes in organization, students and language learning that language trips, as contrasted with educational trips (of which language trips are a subgroup) have gone through in the last years. The article emphasizes the need to differentiate between language trips and language tourism based on issues of additional…

  10. A Field Trip without Buses: Connecting Your Students to Scientists through a Virtual Visit

    ERIC Educational Resources Information Center

    Adedokun, Omolola; Parker, Loran Carleton; Loizzo, Jamie; Burgess, Wilella; Robinson, J. Paul

    2011-01-01

    One school offers zipTrips as an alternative to actual field trips taken outside of school. ZipTrips are web- and broadcast-delivered electronic field trips that include online videos, lesson plans, and a live, 45-minute interactive program consisting of four core components: an in-studio audience, live interaction with scientists, prerecorded…

  11. Managing the effect of TRIPS on availability of priority vaccines.

    PubMed Central

    Milstien, Julie; Kaddar, Miloud

    2006-01-01

    The stated purpose of intellectual property protection is to stimulate innovation. The Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS) requires all Members of the World Trade Organization (WTO) to enact national laws conferring minimum standards of intellectual property protection by certain deadlines. Critics of the Agreement fear that such action is inconsistent with ensuring access to medicines in the developing world. A WHO convened meeting on intellectual property rights and vaccines in developing countries, on which this paper is based, found no evidence that TRIPS has stimulated innovation in developing market vaccine development (where markets are weak) or that protection of intellectual property rights has had a negative effect on access to vaccines. However, access to future vaccines in the developing world could be threatened by compliance with TRIPS. The management of such threats requires adherence of all countries to the Doha Declaration on TRIPS, and the protections guaranteed by the Agreement itself, vigilance on TRIPS-plus elements of free trade agreements, developing frameworks for licensing and technology transfer, and promoting innovative vaccine development in developing countries. The role of international organizations in defining best practices, dissemination of information, and monitoring TRIPS impact will be crucial to ensuring optimal access to priority new vaccines for the developing world. PMID:16710544

  12. Causal models of trip replanning in TravTek

    SciTech Connect

    Schryver, J.C.

    1998-07-01

    The TravTek operational field test was conducted to evaluate the effectiveness of route planning, route guidance and various navigational aiding modalities for Advanced Traveler Information Systems in ground vehicles. A causal network was constructed in order to achieve a better understanding of the dependencies among variables implicated in the replanning process. Causal inferences were modeled using path analysis techniques. The original Yoked Driver study reported that addition of real-time navigation planning did not increase trip efficiency during initial trip planning. Data mining of the relatively complete database revealed that the incidence of dynamic trip replanning was only 0.51% or 1 out of every 198 trips. Nevertheless, the replanning acceptance rate was 92.8%, suggesting that less conservative criteria might have been acceptable to drivers. Several points can be made based upon the path analysis techniques. Drivers who rejected better route offers were more likely to be male renters; rejected routes were apparently offered at earlier times with a lower predicted time savings and fewer maneuvers. Failure to accept a better route also apparently resulted in fewer wrong-turn deviations. Contrary to expectations, wrong-turn count and time loss appeared as semi-independent hubs in the resultant causal network. Implications of the path analysis are discussed. Proposals for in-vehicle information systems are formulated to increase driver participation as co-planner, and increase the likelihood that trip replanning will positively impact trip efficiency.

  13. Wanted: Scalable Tracers for Diffusion Measurements

    PubMed Central

    2015-01-01

    Scalable tracers are potentially a useful tool to examine diffusion mechanisms and to predict diffusion coefficients, particularly for hindered diffusion in complex, heterogeneous, or crowded systems. Scalable tracers are defined as a series of tracers varying in size but with the same shape, structure, surface chemistry, deformability, and diffusion mechanism. Both chemical homology and constant dynamics are required. In particular, branching must not vary with size, and there must be no transition between ordinary diffusion and reptation. Measurements using scalable tracers yield the mean diffusion coefficient as a function of size alone; measurements using nonscalable tracers yield the variation due to differences in the other properties. Candidate scalable tracers are discussed for two-dimensional (2D) diffusion in membranes and three-dimensional diffusion in aqueous solutions. Correlations to predict the mean diffusion coefficient of globular biomolecules from molecular mass are reviewed briefly. Specific suggestions for the 3D case include the use of synthetic dendrimers or random hyperbranched polymers instead of dextran and the use of core–shell quantum dots. Another useful tool would be a series of scalable tracers varying in deformability alone, prepared by varying the density of crosslinking in a polymer to make say “reinforced Ficoll” or “reinforced hyperbranched polyglycerol.” PMID:25319586

  14. Wanted: scalable tracers for diffusion measurements.

    PubMed

    Saxton, Michael J

    2014-11-13

    Scalable tracers are potentially a useful tool to examine diffusion mechanisms and to predict diffusion coefficients, particularly for hindered diffusion in complex, heterogeneous, or crowded systems. Scalable tracers are defined as a series of tracers varying in size but with the same shape, structure, surface chemistry, deformability, and diffusion mechanism. Both chemical homology and constant dynamics are required. In particular, branching must not vary with size, and there must be no transition between ordinary diffusion and reptation. Measurements using scalable tracers yield the mean diffusion coefficient as a function of size alone; measurements using nonscalable tracers yield the variation due to differences in the other properties. Candidate scalable tracers are discussed for two-dimensional (2D) diffusion in membranes and three-dimensional diffusion in aqueous solutions. Correlations to predict the mean diffusion coefficient of globular biomolecules from molecular mass are reviewed briefly. Specific suggestions for the 3D case include the use of synthetic dendrimers or random hyperbranched polymers instead of dextran and the use of core-shell quantum dots. Another useful tool would be a series of scalable tracers varying in deformability alone, prepared by varying the density of crosslinking in a polymer to make say "reinforced Ficoll" or "reinforced hyperbranched polyglycerol."

  15. Active Boundary Layer Trip for Supersonic Flows

    NASA Astrophysics Data System (ADS)

    Schloegel, F.; Panigua, G.; Tirtey, S.

    2009-01-01

    The last decade has been full of excitement and success for the hypersonic community thanks to various Scramjet ground tests and launches. These studies have shown promising potentials but the viability to perform commercial flights at Mach 8 is still to be demonstrated. An ideal Scramjet is one which is capable of self- starting over a wide range of angles of attack and Mach number. The Scramjet designer has to ensure that the boundary layer over the inlet ramp is fully turbulent where shocks impact, hence reducing the risks of chocked flow conditions. Most studies have issued the efficiency of roughness trip to trigger the boundary layer transition. At hypersonic speed, heat transfer and drag dramatically increase resulting in skin friction averaging at 40% of the overall drag. This study investigates the possibility of triggering transition using perpendicular air jets on a flat plate place in a hypersonic cross-flow. Experiments were conducted in the von Karman Institute hypersonic blow down wind tunnel H3. This facility is mounted with a Mach 6 contoured nozzles and provides flows with Reynolds number in the range of 10x106/m to 30x106/m. The model consist of a flat plate manufactured with a built -in settling chamber, equipped with a pressure tap and a thermocouple to monitor the jet conditions. A first flat plate was manufactured with a black-coated Plexiglas top, for surface heat transfer measurement using an infrared camera. On the second model, a Upilex sheet equipped with 32 thin film gages was glued, time dependent heat transfer measurements up to 60kHz. The jet injection conditions have been varied and a Mach number of 5.5 kept constant. The flow topology was investigated using fast schlieren techniques and oil flow, in order to gain a better understanding.

  16. SuperLU{_}DIST: A scalable distributed-memory sparse direct solver for unsymmetric linear systems

    SciTech Connect

    Li, Xiaoye S.; Demmel, James W.

    2002-03-27

    In this paper, we present the main algorithmic features in the software package SuperLU{_}DIST, a distributed-memory sparse direct solver for large sets of linear equations. We give in detail our parallelization strategies, with focus on scalability issues, and demonstrate the parallel performance and scalability on current machines. The solver is based on sparse Gaussian elimination, with an innovative static pivoting strategy proposed earlier by the authors. The main advantage of static pivoting over classical partial pivoting is that it permits a priori determination of data structures and communication pattern for sparse Gaussian elimination, which makes it more scalable on distributed memory machines. Based on this a priori knowledge, we designed highly parallel and scalable algorithms for both LU decomposition and triangular solve and we show that they are suitable for large-scale distributed memory machines.

  17. Space Situational Awareness Data Processing Scalability Utilizing Google Cloud Services

    NASA Astrophysics Data System (ADS)

    Greenly, D.; Duncan, M.; Wysack, J.; Flores, F.

    Space Situational Awareness (SSA) is a fundamental and critical component of current space operations. The term SSA encompasses the awareness, understanding and predictability of all objects in space. As the population of orbital space objects and debris increases, the number of collision avoidance maneuvers grows and prompts the need for accurate and timely process measures. The SSA mission continually evolves to near real-time assessment and analysis demanding the need for higher processing capabilities. By conventional methods, meeting these demands requires the integration of new hardware to keep pace with the growing complexity of maneuver planning algorithms. SpaceNav has implemented a highly scalable architecture that will track satellites and debris by utilizing powerful virtual machines on the Google Cloud Platform. SpaceNav algorithms for processing CDMs outpace conventional means. A robust processing environment for tracking data, collision avoidance maneuvers and various other aspects of SSA can be created and deleted on demand. Migrating SpaceNav tools and algorithms into the Google Cloud Platform will be discussed and the trials and tribulations involved. Information will be shared on how and why certain cloud products were used as well as integration techniques that were implemented. Key items to be presented are: 1.Scientific algorithms and SpaceNav tools integrated into a scalable architecture a) Maneuver Planning b) Parallel Processing c) Monte Carlo Simulations d) Optimization Algorithms e) SW Application Development/Integration into the Google Cloud Platform 2. Compute Engine Processing a) Application Engine Automated Processing b) Performance testing and Performance Scalability c) Cloud MySQL databases and Database Scalability d) Cloud Data Storage e) Redundancy and Availability

  18. A scalable micro-mixer for biomedical applications

    NASA Astrophysics Data System (ADS)

    Cortelezzi, Luca; Ferrari, Simone; Dubini, Angelo

    2016-11-01

    Our study presents a geometrically scalable active micro-mixer suitable for biomedical/bioengineering applications and potentially assimilable in a Lab-on-Chip. We designed our micro-mixer with the goal of satisfying the following constraints: small dimensions, because the device must be able to process volumes of fluid in the range of 10-6 ÷10-9 liters; high mixing speed, because mixing should be obtained in the shortest possible time; constructive simplicity, to facilitate realizability, assimilability and reusability of the micro-mixer; and geometrical scalability, because the micro-mixer should be assimilable to microfluidic systems of different dimensions. We studied numerically the mixing performance of our micro-mixer both in two- and three-dimensions. We characterize the mixing performance in terms of Reynolds, Strouhal and Péclet numbers in order to establish a practical range of operating conditions for our micro-mixer. Finally, we show that our micro-mixer is geometrically scalable, ie., micro-mixers of different geometrical dimensions having the same nondimensional specifications produce nearly the same mixing performance.

  19. Event metadata records as a testbed for scalable data mining

    NASA Astrophysics Data System (ADS)

    van Gemmeren, P.; Malon, D.

    2010-04-01

    At a data rate of 200 hertz, event metadata records ("TAGs," in ATLAS parlance) provide fertile grounds for development and evaluation of tools for scalable data mining. It is easy, of course, to apply HEP-specific selection or classification rules to event records and to label such an exercise "data mining," but our interest is different. Advanced statistical methods and tools such as classification, association rule mining, and cluster analysis are common outside the high energy physics community. These tools can prove useful, not for discovery physics, but for learning about our data, our detector, and our software. A fixed and relatively simple schema makes TAG export to other storage technologies such as HDF5 straightforward. This simplifies the task of exploiting very-large-scale parallel platforms such as Argonne National Laboratory's BlueGene/P, currently the largest supercomputer in the world for open science, in the development of scalable tools for data mining. Using a domain-neutral scientific data format may also enable us to take advantage of existing data mining components from other communities. There is, further, a substantial literature on the topic of one-pass algorithms and stream mining techniques, and such tools may be inserted naturally at various points in the event data processing and distribution chain. This paper describes early experience with event metadata records from ATLAS simulation and commissioning as a testbed for scalable data mining tool development and evaluation.

  20. Scalable fault tolerant image communication and storage grid

    NASA Astrophysics Data System (ADS)

    Slik, David; Seiler, Oliver; Altman, Tym; Montour, Mike; Kermani, Mohammad; Proseilo, Walter; Terry, David; Kawahara, Midori; Leckie, Chris; Muir, Dale

    2003-05-01

    Increasing production and use of digital medical imagery are driving new approaches to information storage and management. Traditional, centralized approaches to image communication, storage and archiving are becoming increasingly expensive to scale and operate with high levels of reliability. Multi-site, geographically-distributed deployments connected by limited-bandwidth networks present further scalability, reliability, and availability challenges. A grid storage architecture built from a distributed network of low cost, off-the-shelf servers (nodes) provides scalable data and metadata storage, processing, and communication without single points of failure. Imaging studies are stored, replicated, cached, managed, and retrieved based on defined rules, and nodes within the grid can acquire studies and respond to queries. Grid nodes transparently load-balance queries, storage/retrieval requests, and replicate data for automated backup and disaster recovery. This approach reduces latency, increases availability, provides near-linear scalability and allows the creation of a geographically distributed medical imaging network infrastructure. This paper presents some key concepts in grid storage and discusses the results of a clinical deployment of a multi-site storage grid for cancer care in the province of British Columbia.

  1. The intergroup protocols: Scalable group communication for the internet

    SciTech Connect

    Berket, Karlo

    2000-12-04

    Reliable group ordered delivery of multicast messages in a distributed system is a useful service that simplifies the programming of distributed applications. Such a service helps to maintain the consistency of replicated information and to coordinate the activities of the various processes. With the increasing popularity of the Internet, there is an increasing interest in scaling the protocols that provide this service to the environment of the Internet. The InterGroup protocol suite, described in this dissertation, provides such a service, and is intended for the environment of the Internet with scalability to large numbers of nodes and high latency links. The InterGroup protocols approach the scalability problem from various directions. They redefine the meaning of group membership, allow voluntary membership changes, add a receiver-oriented selection of delivery guarantees that permits heterogeneity of the receiver set, and provide a scalable reliability service. The InterGroup system comprises several components, executing at various sites within the system. Each component provides part of the services necessary to implement a group communication system for the wide-area. The components can be categorized as: (1) control hierarchy, (2) reliable multicast, (3) message distribution and delivery, and (4) process group membership. We have implemented a prototype of the InterGroup protocols in Java, and have tested the system performance in both local-area and wide-area networks.

  2. A Robust Scalable Transportation System Concept

    NASA Technical Reports Server (NTRS)

    Hahn, Andrew; DeLaurentis, Daniel

    2006-01-01

    This report documents the 2005 Revolutionary System Concept for Aeronautics (RSCA) study entitled "A Robust, Scalable Transportation System Concept". The objective of the study was to generate, at a high-level of abstraction, characteristics of a new concept for the National Airspace System, or the new NAS, under which transportation goals such as increased throughput, delay reduction, and improved robustness could be realized. Since such an objective can be overwhelmingly complex if pursued at the lowest levels of detail, instead a System-of-Systems (SoS) approach was adopted to model alternative air transportation architectures at a high level. The SoS approach allows the consideration of not only the technical aspects of the NAS", but also incorporates policy, socio-economic, and alternative transportation system considerations into one architecture. While the representations of the individual systems are basic, the higher level approach allows for ways to optimize the SoS at the network level, determining the best topology (i.e. configuration of nodes and links). The final product (concept) is a set of rules of behavior and network structure that not only satisfies national transportation goals, but represents the high impact rules that accomplish those goals by getting the agents to "do the right thing" naturally. The novel combination of Agent Based Modeling and Network Theory provides the core analysis methodology in the System-of-Systems approach. Our method of approach is non-deterministic which means, fundamentally, it asks and answers different questions than deterministic models. The nondeterministic method is necessary primarily due to our marriage of human systems with technological ones in a partially unknown set of future worlds. Our goal is to understand and simulate how the SoS, human and technological components combined, evolve.

  3. Scalable k-means statistics with Titan.

    SciTech Connect

    Thompson, David C.; Bennett, Janine C.; Pebay, Philippe Pierre

    2009-11-01

    This report summarizes existing statistical engines in VTK/Titan and presents both the serial and parallel k-means statistics engines. It is a sequel to [PT08], [BPRT09], and [PT09] which studied the parallel descriptive, correlative, multi-correlative, principal component analysis, and contingency engines. The ease of use of the new parallel k-means engine is illustrated by the means of C++ code snippets and algorithm verification is provided. This report justifies the design of the statistics engines with parallel scalability in mind, and provides scalability and speed-up analysis results for the k-means engine.

  4. Validation of a Scalable Solar Sailcraft

    NASA Technical Reports Server (NTRS)

    Murphy, D. M.

    2006-01-01

    The NASA In-Space Propulsion (ISP) program sponsored intensive solar sail technology and systems design, development, and hardware demonstration activities over the past 3 years. Efforts to validate a scalable solar sail system by functional demonstration in relevant environments, together with test-analysis correlation activities on a scalable solar sail system have recently been successfully completed. A review of the program, with descriptions of the design, results of testing, and analytical model validations of component and assembly functional, strength, stiffness, shape, and dynamic behavior are discussed. The scaled performance of the validated system is projected to demonstrate the applicability to flight demonstration and important NASA road-map missions.

  5. Principles of TRIP Steel Optimization for Passive Damping Applications

    NASA Astrophysics Data System (ADS)

    Fraley, George Jay

    Globally many historic structures of cultural significance which do not have systems to mitigate seismic damage are located in areas with heavy seismic activity. Efforts have been undertaken to develop strategies to retrofit such structures, however any intervention must be limited in size for aesthetic reasons. To contribute to this effort, ArcelorMittal aims to create steel-based solutions for passive energy dissipation through plastic deformation during cyclic loading. High-strength TRansformation-Induced Plasticity (TRIP) steels are proposed as an excellent candidate material for this application, due to the extreme combination of high strength and large ductility they are well-known to exhibit. To evaluate high-strength TRIP steels for passive damping applications, isothermal, fully-reversed, displacement-controlled Ultra-Low Cycle Fatigue (ULCF) experiments (Nf < 100) were conducted on two tempering conditions of austenitic BlastAlloy (BA) TRIP 180. One tempering condition resulted in a Mssigma temperature of 27 °C and stress-assisted martensitic nucleation, and the other a Mssigma temperature of -8 °C and strain-induced martensitic nucleation at room temperature. The higher austenite stability condition (Ms sigma = -8 °C) was found to have approximately twice the fatigue life and a lower rate of cyclic hardening at fixed displacement amplitudes for low to intermediate levels of plastic strain range (2-10%) compared to the lower stability austenite condition (Mssigma = 27 °C). However, at higher levels of plastic straining (10-16% strain range) the fatigue lives and strain hardening behavior converged for the two stabilities, indicating a likely exhaustion of transformation during the first few cycles. ULCF life behavior for the high-stability austenite condition compared favorably with literature values for structural stainless steel 316, despite having a yield strength approximately four times larger. For a similar number of cycles to failure the high

  6. Scalability of Localized Arc Filament Plasma Actuators

    NASA Technical Reports Server (NTRS)

    Brown, Clifford A.

    2008-01-01

    Temporal flow control of a jet has been widely studied in the past to enhance jet mixing or reduce jet noise. Most of this research, however, has been done using small diameter low Reynolds number jets that often have little resemblance to the much larger jets common in real world applications because the flow actuators available lacked either the power or bandwidth to sufficiently impact these larger higher energy jets. The Localized Arc Filament Plasma Actuators (LAFPA), developed at the Ohio State University (OSU), have demonstrated the ability to impact a small high speed jet in experiments conducted at OSU and the power to perturb a larger high Reynolds number jet in experiments conducted at the NASA Glenn Research Center. However, the response measured in the large-scale experiments was significantly reduced for the same number of actuators compared to the jet response found in the small-scale experiments. A computational study has been initiated to simulate the LAFPA system with additional actuators on a large-scale jet to determine the number of actuators required to achieve the same desired response for a given jet diameter. Central to this computational study is a model for the LAFPA that both accurately represents the physics of the actuator and can be implemented into a computational fluid dynamics solver. One possible model, based on pressure waves created by the rapid localized heating that occurs at the actuator, is investigated using simplified axisymmetric simulations. The results of these simulations will be used to determine the validity of the model before more realistic and time consuming three-dimensional simulations are conducted to ultimately determine the scalability of the LAFPA system.

  7. Parallel Heuristics for Scalable Community Detection

    SciTech Connect

    Lu, Howard; Kalyanaraman, Anantharaman; Halappanavar, Mahantesh; Choudhury, Sutanay

    2014-05-17

    Community detection has become a fundamental operation in numerous graph-theoretic applications. It is used to reveal natural divisions that exist within real world networks without imposing prior size or cardinality constraints on the set of communities. Despite its potential for application, there is only limited support for community detection on large-scale parallel computers, largely owing to the irregular and inherently sequential nature of the underlying heuristics. In this paper, we present parallelization heuristics for fast community detection using the Louvain method as the serial template. The Louvain method is an iterative heuristic for modularity optimization. Originally developed by Blondel et al. in 2008, the method has become increasingly popular owing to its ability to detect high modularity community partitions in a fast and memory-efficient manner. However, the method is also inherently sequential, thereby limiting its scalability to problems that can be solved on desktops. Here, we observe certain key properties of this method that present challenges for its parallelization, and consequently propose multiple heuristics that are designed to break the sequential barrier. Our heuristics are agnostic to the underlying parallel architecture. For evaluation purposes, we implemented our heuristics on shared memory (OpenMP) and distributed memory (MapReduce-MPI) machines, and tested them over real world graphs derived from multiple application domains (internet, biological, natural language processing). Experimental results demonstrate the ability of our heuristics to converge to high modularity solutions comparable to those output by the serial algorithm in nearly the same number of iterations, while also drastically reducing time to solution.

  8. A study on rate sensitivity of elasto-plastic fracture toughness of TRIP steel evaluated by a small punch test

    NASA Astrophysics Data System (ADS)

    Iwamoto, T.; Hashimoto, S.-ya; Shi, L.

    2012-08-01

    TRIP steel indicates an excellent characteristic in energy absorption because of its high ductility and strength by strain-induced martensitic transformation (SIMT). Recently, some shock absorption members are being used for automotive industries. For good fuel consumption of the automobile, it would realize the weight reduction without decaying performance if TRIP steel can be applied to those members. It can be considered that the fracture toughness is an important factor to evaluate the performance. To evaluate fracture toughness locally at any point of a product of those members, small punch testing method is quite effective. In the present study, first, an impact small punch testing apparatus is established. In addition, elasto-plastic fracture toughness of TRIP steel under impact loading and its rate sensitivity tested at various deflection rates are challenged to evaluate.

  9. Analysis of the equilibrium trip cost without late arrival and the corresponding traffic properties using a car-following model

    NASA Astrophysics Data System (ADS)

    Tang, Tie-Qiao; Chen, Liang; Huang, Hai-Jun; Song, Ziqi

    2016-10-01

    In this paper, we first apply a generalized car-following model to study the commuter trip cost without late arrival from an analytical perspective; and then use the full velocity difference (FVD) model to verify the analytical results and explore the corresponding traffic properties from a numerical perspective. Finally, we explore the evolutions of traffic flow on a road with an open boundary under three traffic situations (i.e., the number of commuters is low, moderate, and high) and find that the evolution of traffic flow is related to the number of commuters. The numerical results are qualitatively consistent with the analytical results and illustrate that car-following models can be used to study each commuter's trip cost without late arrival and that the car-following model can accurately quantify each commuter's trip cost.

  10. Field Trips and Their Effect on Student Achievement and Attitudes: A Comparison of Physical versus Virtual Field Trips to the Indian River Lagoon

    ERIC Educational Resources Information Center

    Garner, Lesley C.; Gallo, Michael A.

    2005-01-01

    This study examined the effect of physical and virtual field trips on undergraduate, nonscience majors. No significant differences were seen in achievement, attitudes, learning styles, interactions between field trip and learning styles, or students' ability to answer questions at different levels. Results imply that both field trips promote…

  11. (Collection of North Pacific Ocean surface seawater samples from a container ship): Foreign trip report, January 24--March 4, 1989

    SciTech Connect

    Goddard, J.G.

    1989-03-16

    This trip was a continuation of the sampling program undertaken during 1984--1985 to study the seasonal and regional variability of CO/sub 2/ chemistry in high-latitude deep water formation areas of the North Pacific. The work is conducted by Columbia University (Dr. Taro Takahashi, Principal Investigator) for the Department of Energy's Energy Systems Program managed by Oak Ridge National Laboratory. Aboard the President Eisenhower, we collected surface seawater samples at forty-two stations along the route from Oakland, California, to Keelung, Taiwan, via Guam. On the return trip, samples were collected from thirty-nine stations during transit from Kaohsiung, Taiwan, to Los Angeles, California.

  12. (Collection of North Pacific Ocean surface seawater samples for chemical analysis): Foreign trip report, January 26--February 27, 1988

    SciTech Connect

    Goddard, J.G.

    1988-03-04

    This trip was a continuation of the sampling program undertaken during 1984--1985 to study the seasonal and regional variability of CO/sub 2/ chemistry in high latitude deep water formation areas of the North Pacific. The work is conducted by Columbia University (Dr. Taro Takahashi, Principal Investigator) for the Department of Energy's Energy Systems Program managed by Oak Ridge National Laboratory. Aboard the PRESIDENT ARTHUR, surface seawater samples were collected at forty-one stations along the route from Oakland, California, to Keeling, Taiwan, via Guam. On the return trip, samples were collected from thirty-seven stations during transit from Keelung to Los Angeles, California.

  13. Fundamental study of the austenite formation and decomposition in low-silicon, aluminum added TRIP steels

    NASA Astrophysics Data System (ADS)

    Garcia-Gonzalez, Jose Enrique

    2005-11-01

    TRIP (Transformation Induced Plasticity) steels are under development for automotive applications that require high strength and excellent formability. Conventional TRIP steels consist of a multiphase microstructure comprised of a ferrite matrix with a dispersion of bainite and metastable retained austenite. The high ductility exhibited by these steels results from the transformation of the metastable retained austenite to martensite during straining. In conventional TRIP steel processing, the multiphase microstructure is obtained by controlled cooling from the alpha + gamma region to an isothermal holding temperature. During this holding, bainite forms and carbon is rejected out into the austenite, which lowers the Ms temperature and stabilizes the austenite to room temperature. In this research project, a fundamental study of a low-Si, Mo-Nb added cold rolled TRIP steel with and without Al additions was conducted. In this study, the recrystallization of cold-rolled ferrite, the formation of austenite during intercritical annealing and the characteristics of the decomposition of the intercritically annealed austenite by controlled cooling rates were systematically assessed. Of special interest were: (i) the effect of the initial hot band microstructure, (ii) the formation of epitaxial ferrite during cooling from the intercritical annealing temperature to the isothermal holding temperature, (iii) the influence of the intercritically annealed austenite on the formation of bainite during the isothermal holding temperature, and (iv) the influence of the processing variables on the type, amount, composition and stability of the retained austenite. During this research study, techniques such as OM, SEM, EBSD, TEM, XRD and Magnetometry were used to fully characterize the microstructures. Furthermore, a Gleeble 3500 unit at US Steel Laboratories was used for dilatometry studies and to simulate different CGL processing routes, from which specimens were obtained to evaluate

  14. Scalable Production Method for Graphene Oxide Water Vapor Separation Membranes

    SciTech Connect

    Fifield, Leonard S.; Shin, Yongsoon; Liu, Wei; Gotthold, David W.

    2016-01-01

    ABSTRACT

    Membranes for selective water vapor separation were assembled from graphene oxide suspension using techniques compatible with high volume industrial production. The large-diameter graphene oxide flake suspensions were synthesized from graphite materials via relatively efficient chemical oxidation steps with attention paid to maintaining flake size and achieving high graphene oxide concentrations. Graphene oxide membranes produced using scalable casting methods exhibited water vapor flux and water/nitrogen selectivity performance meeting or exceeding that of membranes produced using vacuum-assisted laboratory techniques. (PNNL-SA-117497)

  15. Influences of cyclic loading on martensite transformation of TRIP steels

    NASA Astrophysics Data System (ADS)

    Dan, W. J.; Hu, Z. G.; Zhang, W. G.

    2013-03-01

    While austenite transformation into martensite induces increasing of the crack initiation life and restraining of the growth of fatigue cracks in cyclic-loading processes, TRIP-assisted steels have a better fatigue life than the AHSS (Advance High Strength Steels). As two key parameters in the cyclic loading process, strain amplitude and cyclic frequency are used in a kinetic transformation model to reasonably evaluate the phase transformation from austenite into martensite with the shear-band intersections theory, in which strain amplitude and cyclic frequency are related to the rate of shear-band intersection formation and the driving force of phase transformation. The results revealed that the martensite volume fraction increased and the rate of phase transformation decrease while the number of cycles increased, and the martensite volume fraction was almost constant after the number of cycles was more than 2000 times. Higher strain amplitude promotes martensite transformation and higher cyclic frequency impedes phase transformation, which are interpreted by temperature increment, the driving force of phase transformation and the rate of shearband intersection formation.

  16. Appraisal of boundary layer trips for landing gear testing

    NASA Astrophysics Data System (ADS)

    McCarthy, Philip; Feltham, Graham; Ekmekci, Alis

    2013-11-01

    Dynamic similarity during scaled model testing is difficult to maintain. Forced boundary layer transition via a surface protuberance is a common method used to address this issue, however few guidelines exist for the effective tripping of complex geometries, such as aircraft landing gears. To address this shortcoming, preliminary wind tunnel tests were performed at Re = 500,000. Surface transition visualisation and pressure measurements show that zigzag type trips of a given size and location are effective at promoting transition, thus preventing the formation of laminar separation bubbles and increasing the effective Reynolds number from the critical regime to the supercritical regime. Extension of these experiments to include three additional tripping methods (wires, roughness strips, CADCUT dots) in a range of sizes, at Reynolds number of 200,000 and below, have been performed in a recirculating water channel. Analysis of surface pressure measurements and time resolved PIV for each trip device, size and location has established a set of recommendations for successful use of tripping for future, low Reynolds number landing gear testing.

  17. Evidence, explanations, and recommendations for teachers' field trip strategies

    NASA Astrophysics Data System (ADS)

    Rebar, Bryan

    Field trips are well recognized by researchers as an educational approach with the potential to complement and enhance classroom science teaching by exposing students to unique activities, resources, and content in informal settings. The following investigation addresses teachers' field trip practices in three related manuscripts: (1) A study examining the details of teachers' pedagogical strategies intended to facilitate connections between students' experiences and the school curricula while visiting an aquarium; (2) A study documenting and describing sources of knowledge that teachers draw from when leading field trips to an aquarium; (3) A position paper that reviews and summarizes research on effective pedagogical strategies for field trips. Together these three pieces address key questions regarding teachers' practices on field trips: (1) What strategies are teachers employing (and not employing) during self-guided field trips to facilitate learning tied to the class curriculum? (2) What sources of knowledge do teachers utilize when leading field trips? (3) How can teachers be better prepared to lead trips that promote learning? The Oregon Coast Aquarium served as the field trip site for teachers included in this study. The setting suited these questions because the aquarium serves tens of thousands of students on field trips each year but provides no targeted programming for these students as they explore the exhibits. In other words, the teachers who lead field trips assume much of the responsibility for facilitating students' experience. In order to describe and characterize teachers' strategies to link students' experiences to the curriculum, a number of teachers (26) were observed as they led their students' visit to the public spaces of the aquarium. Artifacts, such as worksheets, used during the visit were collected for analysis as well. Subsequently, all teachers were surveyed regarding their use of the field trip and their sources of knowledge for

  18. Scalable Domain Decomposed Monte Carlo Particle Transport

    SciTech Connect

    O'Brien, Matthew Joseph

    2013-12-05

    In this dissertation, we present the parallel algorithms necessary to run domain decomposed Monte Carlo particle transport on large numbers of processors (millions of processors). Previous algorithms were not scalable, and the parallel overhead became more computationally costly than the numerical simulation.

  19. Physical principles for scalable neural recording.

    PubMed

    Marblestone, Adam H; Zamft, Bradley M; Maguire, Yael G; Shapiro, Mikhail G; Cybulski, Thaddeus R; Glaser, Joshua I; Amodei, Dario; Stranges, P Benjamin; Kalhor, Reza; Dalrymple, David A; Seo, Dongjin; Alon, Elad; Maharbiz, Michel M; Carmena, Jose M; Rabaey, Jan M; Boyden, Edward S; Church, George M; Kording, Konrad P

    2013-01-01

    Simultaneously measuring the activities of all neurons in a mammalian brain at millisecond resolution is a challenge beyond the limits of existing techniques in neuroscience. Entirely new approaches may be required, motivating an analysis of the fundamental physical constraints on the problem. We outline the physical principles governing brain activity mapping using optical, electrical, magnetic resonance, and molecular modalities of neural recording. Focusing on the mouse brain, we analyze the scalability of each method, concentrating on the limitations imposed by spatiotemporal resolution, energy dissipation, and volume displacement. Based on this analysis, all existing approaches require orders of magnitude improvement in key parameters. Electrical recording is limited by the low multiplexing capacity of electrodes and their lack of intrinsic spatial resolution, optical methods are constrained by the scattering of visible light in brain tissue, magnetic resonance is hindered by the diffusion and relaxation timescales of water protons, and the implementation of molecular recording is complicated by the stochastic kinetics of enzymes. Understanding the physical limits of brain activity mapping may provide insight into opportunities for novel solutions. For example, unconventional methods for delivering electrodes may enable unprecedented numbers of recording sites, embedded optical devices could allow optical detectors to be placed within a few scattering lengths of the measured neurons, and new classes of molecularly engineered sensors might obviate cumbersome hardware architectures. We also study the physics of powering and communicating with microscale devices embedded in brain tissue and find that, while radio-frequency electromagnetic data transmission suffers from a severe power-bandwidth tradeoff, communication via infrared light or ultrasound may allow high data rates due to the possibility of spatial multiplexing. The use of embedded local recording and

  20. Physical principles for scalable neural recording

    PubMed Central

    Zamft, Bradley M.; Maguire, Yael G.; Shapiro, Mikhail G.; Cybulski, Thaddeus R.; Glaser, Joshua I.; Amodei, Dario; Stranges, P. Benjamin; Kalhor, Reza; Dalrymple, David A.; Seo, Dongjin; Alon, Elad; Maharbiz, Michel M.; Carmena, Jose M.; Rabaey, Jan M.; Boyden, Edward S.; Church, George M.; Kording, Konrad P.

    2013-01-01

    Simultaneously measuring the activities of all neurons in a mammalian brain at millisecond resolution is a challenge beyond the limits of existing techniques in neuroscience. Entirely new approaches may be required, motivating an analysis of the fundamental physical constraints on the problem. We outline the physical principles governing brain activity mapping using optical, electrical, magnetic resonance, and molecular modalities of neural recording. Focusing on the mouse brain, we analyze the scalability of each method, concentrating on the limitations imposed by spatiotemporal resolution, energy dissipation, and volume displacement. Based on this analysis, all existing approaches require orders of magnitude improvement in key parameters. Electrical recording is limited by the low multiplexing capacity of electrodes and their lack of intrinsic spatial resolution, optical methods are constrained by the scattering of visible light in brain tissue, magnetic resonance is hindered by the diffusion and relaxation timescales of water protons, and the implementation of molecular recording is complicated by the stochastic kinetics of enzymes. Understanding the physical limits of brain activity mapping may provide insight into opportunities for novel solutions. For example, unconventional methods for delivering electrodes may enable unprecedented numbers of recording sites, embedded optical devices could allow optical detectors to be placed within a few scattering lengths of the measured neurons, and new classes of molecularly engineered sensors might obviate cumbersome hardware architectures. We also study the physics of powering and communicating with microscale devices embedded in brain tissue and find that, while radio-frequency electromagnetic data transmission suffers from a severe power–bandwidth tradeoff, communication via infrared light or ultrasound may allow high data rates due to the possibility of spatial multiplexing. The use of embedded local recording and

  1. Responsive, Flexible and Scalable Broader Impacts (Invited)

    NASA Astrophysics Data System (ADS)

    Decharon, A.; Companion, C.; Steinman, M.

    2010-12-01

    investment of time. Initiated in summer 2010, the webinars are interactive and highly flexible: people can participate from their homes anywhere and can interact according to their comfort levels (i.e., submitting questions in “chat boxes” rather than orally). Expansion - To expand scientists’ research beyond educators attending a workshop or webinar, COSEE-OS uses a blog as an additional mode of communication. Topically focused by concept maps, blogs serve as a forum for scalable content. The varied types of formatting allow scientists to create long-lived resources that remain attributed to them while supporting sustained educator engagement. Blogs are another point of contact and allow educators further asynchronous access to scientists. Based on COSEE-OS evaluations, interacting on a blog was found to be educators’ preferred method of following up with scientists. Sustained engagement of scientists or educators requires a specific return on investment. Workshops and web tools can be used together to maximize scientist impact with a relatively small investment of time. As one educator stated, “It really helps my students’ interest when we discuss concepts and I tell them my knowledge comes directly from a scientist!” [A. deCharon et al. (2009), Online tools help get scientists and educators on the same page, Eos Transactions, American Geophysical Union, 90(34), 289-290.

  2. Hypersonic Boundary-Layer Trip Development for Hyper-X

    NASA Technical Reports Server (NTRS)

    Berry, Scott A.; Auslender, Aaron H.; Dilley, Authur D.; Calleja, John F.

    2000-01-01

    Boundary layer trip devices for the Hper-X forebody have been experimentally examined in several wind tunnels. Five different trip configurations were compared in three hypersonic facilities, the LaRC 20-Inch Mach 6 Air Tunnel, the LaRC 31 -Inch Mach 10 Air Tunnel, and in the HYPULSE Reflected Shock Tunnel at GASL. Heat transfer distributions, utilizing the phosphor thermography and thin-film techniques, shock system details, and surface streamline patterns were measured on a 0.333-scale model of the Hyper-X forebody. Parametric variations include angles-of-attack of 0-deg, 2-deg, and 4-deg; Reynolds numbers based on model length of 1.2 to 15.4 million: and inlet cowl door simulated in both open and closed positions. Comparisons of transition due to discrete roughness elements have led to the selection of a trip configuration for the Hyper-X Mach 7 flight vehicle.

  3. Mechanical and Microstructural Characterization of an Aluminum Bearing Trip Steel

    NASA Astrophysics Data System (ADS)

    Monsalve, Alberto; Guzmán, Alexis; De Barbieri, Flavio; Artigas, Alfredo; Carvajal, Linton; Bustos, Oscar; Garza-Montes-de Oca, Nelson F.; Colás, Rafael

    2016-06-01

    The mechanical properties and microstructural characteristics of a steel able to sustain the TRIP-effect were studied. The material was prepared by taking in mind the partial substitution of silicon by aluminum following a processing route that included hot forging, hot and cold rolling, intercritical annealing, and a final bainitic isothermal treatment. The mechanical properties that were obtained resulted to be above those of commercial a 780 TRIP steel. The TRIP phenomenon was confirmed by the change in retained austenite before and after deforming the steel; X-ray diffraction was used to evaluate the volume content of retained austenite. Formability of the steel under study can be rationalized in terms of the texture developed in the material.

  4. Leg vein hemodynamics during bedrests simulating lunar trip.

    PubMed

    Louisy, F; Guezennec, C Y; Güell, A

    1994-05-01

    When contemplating future trips to the Moon whose gravity is one sixth of Earth gravity, the question is to know what the adaptive changes in the lower limb venous system would be. In fact, one can suppose that the presence of a partial gravity on the Moon would be able to attenuate venous hemodynamics adaptative changes observed in microgravity. In the present experiment changes in the venous hemodynamics of lower limbs have been studied with mercury strain gauge plethysmography during a simulated Moon mission including a 4 day trip to the Moon (-6 degrees bedrest), a stay of 6 days on the Moon (+11 degrees bedrest), and a 4-day trip back to Earth (-6 degrees bedrest). It was previously demonstrated that +11 degrees bedrest was a good model to simulate the effects of lunar gravity on the cardiovascular system (Vernikos-Danellis J 1986, personnal communication).

  5. 3D finite element simulation of effects of deflection rate on energy absorption for TRIP steel

    NASA Astrophysics Data System (ADS)

    Hayashi, Asuka; Pham, Hang; Iwamoto, Takeshi

    2015-09-01

    Recently, with the requirement of lighter weight and more safety for a design of automobile, energy absorption capability of structural materials has become important. TRIP (Transformation-induced Plasticity) steel is expected to apply to safety members because of excellent energy absorption capability and ductility. Past studies proved that such excellent characteristics in TRIP steel are dominated by strain-induced martensitic transformation (SIMT) during plastic deformation. Because SIMT strongly depends on deformation rate and temperature, an investigation of the effects of deformation rate and temperature on energy absorption in TRIP is essential. Although energy absorption capability of material can be estimated by J-integral experimentally by using pre-cracked specimen, it is difficult to determine volume fraction of martensite and temperature rise during the crack extension. In addition, their effects on J-integral, especially at high deformation rate in experiment might be quite hard. Thus, a computational prediction needs to be performed. In this study, bending deformation behavior of pre-cracked specimen until the onset point of crack extension are predicted by 3D finite element simulation based on the transformation kinetics model proposed by Iwamoto et al. (1998). It is challenged to take effects of temperature, volume fraction of martensite and deformation rate into account. Then, the mechanism for higher energy absorption characteristic will be discussed.

  6. Heat transfer in rotating serpentine passages with trips normal to the flow

    NASA Technical Reports Server (NTRS)

    Wagner, J. H.; Johnson, B. V.; Graziani, R. A.; Yeh, F. C.

    1991-01-01

    Experiments were conducted to determine the effects of buoyancy and Coriolis forces on heat transfer in turbine blade internal coolant passages. The experiments were conducted with a large scale, multipass, heat transfer model with both radially inward and outward flow. Trip strips on the leading and trailing surfaces of the radial coolant passages were used to produce the rough walls. An analysis of the governing flow equations showed that four parameters influence the heat transfer in rotating passages: coolant-to-wall temperature ratio, Rossby number, Reynolds number, and radius-to-passage hydraulic diameter ratio. The first three of these four parameters were varied over ranges which are typical of advanced gas turbine engine operating conditions. Results were correlated and compared to previous results from stationary and rotating similar models with trip strips. The heat transfer coefficients on surfaces, where the heat increased with rotation and buoyancy, varied by as much as a factor of four. Maximum values of the heat transfer coefficients with high rotation were only slightly above the highest levels obtained with the smooth wall model. The heat transfer coefficients on surfaces, where the heat transfer decreased with rotation, varied by as much as a factor of three due to rotation and buoyancy. It was concluded that both Coriolis and buoyancy effects must be considered in turbine blade cooling designs with trip strips and that the effects of rotation were markedly different depending upon the flow direction.

  7. TRIP: General computer algebra system for celestial mechanics

    NASA Astrophysics Data System (ADS)

    Laskar, J.; Gastineau, M.

    2012-10-01

    TRIP is an interactive computer algebra system that is devoted to perturbation series computations, and specially adapted to celestial mechanics. Its development started in 1988, as an upgrade of the special purpose FORTRAN routines elaborated by J. Laskar for the demonstration of the chaotic behavior of the Solar System. TRIP is a mature and efficient tool for handling multivariate generalized power series, and embeds two kernels, a symbolic and a numerical kernel. This numerical kernel communicates with Gnuplot or Grace to plot the graphics and allows one to plot the numerical evaluation of symbolic objects.

  8. Bad trip due to anticholinergic effect of cannabis.

    PubMed

    Mangot, Ajish G

    2013-01-01

    Cannabis in its various forms has been known since time immemorial, the use of which has been rising steadily in India. 'Bad trips' have been documented after cannabis use, manifestations ranging from vague anxiety and fear to profoundly disturbing states of terror and psychosis. Cannabis is known to affect various neurotransmitters, but 'bad trip' due to its anticholinergic effect has never been described in literature to the best of author's knowledge. Hereby, the author describes a case of a young adult male experiencing profound anticholinergic effects after being exposed for the first time in his life to bhang, a local oral preparation of cannabis.

  9. Simplex-stochastic collocation method with improved scalability

    SciTech Connect

    Edeling, W.N.; Dwight, R.P.; Cinnella, P.

    2016-04-01

    The Simplex-Stochastic Collocation (SSC) method is a robust tool used to propagate uncertain input distributions through a computer code. However, it becomes prohibitively expensive for problems with dimensions higher than 5. The main purpose of this paper is to identify bottlenecks, and to improve upon this bad scalability. In order to do so, we propose an alternative interpolation stencil technique based upon the Set-Covering problem, and we integrate the SSC method in the High-Dimensional Model-Reduction framework. In addition, we address the issue of ill-conditioned sample matrices, and we present an analytical map to facilitate uniformly-distributed simplex sampling.

  10. Scalable syntheses of the BET bromodomain inhibitor JQ1.

    PubMed

    Syeda, Shameem Sultana; Jakkaraj, Sudhakar; Georg, Gunda I

    2015-06-03

    We have developed methods involving the use of alternate, safer reagents for the scalable syntheses of the potent BET bromodomain inhibitor JQ1. A one-pot three step method, involving the conversion of a benzodiazepine to a thioamde using Lawesson's reagent, followed by amidrazone formation and installation of the triazole moiety furnished JQ1. This method provides good yields and a facile purification process. For the synthesis of enantiomerically enriched (+)-JQ1, the highly toxic reagent diethyl chlorophosphate, used in a previous synthesis, was replaced with the safer reagent diphenyl chlorophosphate in the three-step one-pot triazole formation without effecting yields and enantiomeric purity of (+)-JQ1.

  11. pcircle - A Suite of Scalable Parallel File System Tools

    SciTech Connect

    WANG, FEIYI

    2015-10-01

    Most of the software related to file system are written for conventional local file system, they are serialized and can't take advantage of the benefit of a large scale parallel file system. "pcircle" software builds on top of ubiquitous MPI in cluster computing environment and "work-stealing" pattern to provide a scalable, high-performance suite of file system tools. In particular - it implemented parallel data copy and parallel data checksumming, with advanced features such as async progress report, checkpoint and restart, as well as integrity checking.

  12. Scalable C-H Oxidation with Copper: Synthesis of Polyoxypregnanes.

    PubMed

    See, Yi Yang; Herrmann, Aaron T; Aihara, Yoshinori; Baran, Phil S

    2015-11-04

    Steroids bearing C12 oxidations are widespread in nature, yet only one preparative chemical method addresses this challenge in a low-yielding and not fully understood fashion: Schönecker's Cu-mediated oxidation. This work shines new light onto this powerful C-H oxidation method through mechanistic investigation, optimization, and wider application. Culminating in a scalable, rapid, high-yielding, and operationally simple protocol, this procedure is applied to the first synthesis of several parent polyoxypregnane natural products, representing a gateway to over 100 family members.

  13. Scalable orbital-angular-momentum sorting without destroying photon states

    NASA Astrophysics Data System (ADS)

    Wang, Fang-Xiang; Chen, Wei; Yin, Zhen-Qiang; Wang, Shuang; Guo, Guang-Can; Han, Zheng-Fu

    2016-09-01

    Single photons with orbital angular momentum (OAM) have attracted substantial attention from researchers. A single photon can carry infinite OAM values theoretically. Thus, OAM photon states have been widely used in quantum information and fundamental quantum mechanics. Although there have been many methods for sorting quantum states with different OAM values, the nondestructive and efficient sorter of high-dimensional OAM remains a fundamental challenge. Here, we propose a scalable OAM sorter which can categorize different OAM states simultaneously, meanwhile, preserving both OAM and spin angular momentum. Fundamental elements of the sorter are composed of symmetric multiport beam splitters (BSs) and Dove prisms with cascading structure, which in principle can be flexibly and effectively combined to sort arbitrarily high-dimensional OAM photons. The scalable structures proposed here greatly reduce the number of BSs required for sorting high-dimensional OAM states. In view of the nondestructive and extensible features, the sorters can be used as fundamental devices not only for high-dimensional quantum information processing, but also for traditional optics.

  14. Scalable extensions of HEVC for next generation services

    NASA Astrophysics Data System (ADS)

    Misra, Kiran; Segall, Andrew; Zhao, Jie; Kim, Seung-Hwan

    2013-02-01

    The high efficiency video coding (HEVC) standard being developed by ITU-T VCEG and ISO/IEC MPEG achieves a compression goal of reducing the bitrate by half for the same visual quality when compared with earlier video compression standards such as H.264/AVC. It achieves this goal with the use of several new tools such as quad-tree based partitioning of data, larger block sizes, improved intra prediction, the use of sophisticated prediction of motion information, inclusion of an in-loop sample adaptive offset process etc. This paper describes an approach where the HEVC framework is extended to achieve spatial scalability using a multi-loop approach. The enhancement layer inter-predictive coding efficiency is improved by including within the decoded picture buffer multiple up-sampled versions of the decoded base layer picture. This approach has the advantage of achieving significant coding gains with a simple extension of the base layer tools such as inter-prediction, motion information signaling etc. Coding efficiency of the enhancement layer is further improved using adaptive loop filter and internal bit-depth increment. The performance of the proposed scalable video coding approach is compared to simulcast transmission of video data using high efficiency model version 6.1 (HM-6.1). The bitrate savings are measured using Bjontegaard Delta (BD) rate for a spatial scalability factor of 2 and 1.5 respectively when compared with simulcast anchors. It is observed that the proposed approach provides an average luma BD rate gains of 33.7% and 50.5% respectively.

  15. Scalable Molecular Dynamics with NAMD

    PubMed Central

    Phillips, James C.; Braun, Rosemary; Wang, Wei; Gumbart, James; Tajkhorshid, Emad; Villa, Elizabeth; Chipot, Christophe; Skeel, Robert D.; Kalé, Laxmikant; Schulten, Klaus

    2008-01-01

    NAMD is a parallel molecular dynamics code designed for high-performance simulation of large biomolecular systems. NAMD scales to hundreds of processors on high-end parallel platforms, as well as tens of processors on low-cost commodity clusters, and also runs on individual desktop and laptop computers. NAMD works with AMBER and CHARMM potential functions, parameters, and file formats. This paper, directed to novices as well as experts, first introduces concepts and methods used in the NAMD program, describing the classical molecular dynamics force field, equations of motion, and integration methods along with the efficient electrostatics evaluation algorithms employed and temperature and pressure controls used. Features for steering the simulation across barriers and for calculating both alchemical and conformational free energy differences are presented. The motivations for and a roadmap to the internal design of NAMD, implemented in C++ and based on Charm++ parallel objects, are outlined. The factors affecting the serial and parallel performance of a simulation are discussed. Next, typical NAMD use is illustrated with representative applications to a small, a medium, and a large biomolecular system, highlighting particular features of NAMD, e.g., the Tcl scripting language. Finally, the paper provides a list of the key features of NAMD and discusses the benefits of combining NAMD with the molecular graphics/sequence analysis software VMD and the grid computing/collaboratory software BioCoRE. NAMD is distributed free of charge with source code at www.ks.uiuc.edu. PMID:16222654

  16. Scalable descriptive and correlative statistics with Titan.

    SciTech Connect

    Thompson, David C.; Pebay, Philippe Pierre

    2008-12-01

    This report summarizes the existing statistical engines in VTK/Titan and presents the parallel versions thereof which have already been implemented. The ease of use of these parallel engines is illustrated by the means of C++ code snippets. Furthermore, this report justifies the design of these engines with parallel scalability in mind; then, this theoretical property is verified with test runs that demonstrate optimal parallel speed-up with up to 200 processors.

  17. Scalable Quantum Information Processing and Applications

    DTIC Science & Technology

    2008-01-19

    Read-out Channel Depletion Gate (-V) Read-out Channel Depletion Gate (-V) Source Drain Qubit Control Gates for Quantum Teleportation Spin Coherent...REPORT Scalable Quantum Information Processing and Applications: Final Report 14. ABSTRACT 16. SECURITY CLASSIFICATION OF: The main goal of this...Office P.O. Box 12211 Research Triangle Park, NC 27709-2211 15. SUBJECT TERMS Quantum repeater, quantum computing, quantum information processing

  18. Scalable and Sustainable Electrochemical Allylic C–H Oxidation

    PubMed Central

    Chen, Yong; Tang, Jiaze; Chen, Ke; Eastgate, Martin D.; Baran, Phil S.

    2016-01-01

    New methods and strategies for the direct functionalization of C–H bonds are beginning to reshape the fabric of retrosynthetic analysis, impacting the synthesis of natural products, medicines, and even materials1. The oxidation of allylic systems has played a prominent role in this context as possibly the most widely applied C–H functionalization due to the utility of enones and allylic alcohols as versatile intermediates, along with their prevalence in natural and unnatural materials2. Allylic oxidations have been featured in hundreds of syntheses, including some natural product syntheses regarded as “classics”3. Despite many attempts to improve the efficiency and practicality of this powerful transformation, the vast majority of conditions still employ highly toxic reagents (based around toxic elements such as chromium, selenium, etc.) or expensive catalysts (palladium, rhodium, etc.)2. These requirements are highly problematic in industrial settings; currently, no scalable and sustainable solution to allylic oxidation exists. As such, this oxidation strategy is rarely embraced for large-scale synthetic applications, limiting the adoption of this important retrosynthetic strategy by industrial scientists. In this manuscript, we describe an electrochemical solution to this problem that exhibits broad substrate scope, operational simplicity, and high chemoselectivity. This method employs inexpensive and readily available materials, representing the first example of a scalable allylic C–H oxidation (demonstrated on 100 grams), finally opening the door for the adoption of this C–H oxidation strategy in large-scale industrial settings without significant environmental impact. PMID:27096371

  19. 50 CFR 622.44 - Commercial trip limits.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Caribbean EEZ more than 150 queen conch per day. (f) Atlantic dolphin and wahoo. (1) The trip limit for... Federal commercial permit for Atlantic dolphin and wahoo, provided that the vessel is not operating as a... permit for Atlantic dolphin and wahoo but has a Federal commercial vessel permit in any other fishery...

  20. 50 CFR 622.278 - Commercial trip limits.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE FISHERIES OF THE CARIBBEAN, GULF OF MEXICO, AND SOUTH ATLANTIC Dolphin and... limits on the amount of Atlantic dolphin and wahoo that may be possessed on board or landed, purchased...) Atlantic dolphin and wahoo. (1) The trip limit for wahoo in or from the Atlantic EEZ is 500 lb (227...

  1. 50 CFR 622.278 - Commercial trip limits.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE FISHERIES OF THE CARIBBEAN, GULF OF MEXICO, AND SOUTH ATLANTIC Dolphin and... limits on the amount of Atlantic dolphin and wahoo that may be possessed on board or landed, purchased...) Atlantic dolphin and wahoo. (1) The trip limit for wahoo in or from the Atlantic EEZ is 500 lb (227...

  2. Planning a Class Camping Trip. ERIC Digest: Outdoor Education.

    ERIC Educational Resources Information Center

    Little, Mickey; Peterson, Lin

    A well-planned class camping trip is a learning adventure which develops personal values, generates lifelong learning skills, encourages group cooperation, and enhances knowledge of and appreciation for natural environments. This digest is a guide to help teachers offer this unique learning opportunity to their students. Separate sections present…

  3. Journal of South African Trip: January 14-March 1, 1986.

    ERIC Educational Resources Information Center

    Rogers, Carl R.

    1987-01-01

    Provides a personal account, dictated en route, of Carl Rogers' experiences during his trip to South Africa. Documents extensive commitment to people and to a process leading to peace. Journal ends with conviction that violence can be avoided and that no group really wants violence. (Author)

  4. Cognitive Impact of a Grade School Field Trip.

    ERIC Educational Resources Information Center

    Morrell, Patricia D.

    2003-01-01

    Presents a study to design and conduct a three-hour field experience for 3rd and 4th grade students on forestry and forest products, and to determine the cognitive effects of participation in this field trip on the children. Reports an increase in student knowledge after participating in this experience. Discusses the reasons for students'…

  5. Un Viaje al Aeropuerto (A Trip to the Airport).

    ERIC Educational Resources Information Center

    Federal Aviation Administration (DOT), Washington, DC.

    This illustrated, bilingual Spanish-English intermediate reader describes a class trip to an airport, in which the class tours the airport, and learns about airport activities, the parts of an airplane, and other related topics. Each page of the text is illustrated with a drawing. The narrative is followed by a list of 24 suggested learning…

  6. Examining the Effects of Field Trips on Science Identity

    ERIC Educational Resources Information Center

    Mills, Leila A.; Katzman, William

    2015-01-01

    The purpose of this work-in-progress study is to examine science identity of elementary school students in relation to participation in science. The questions asked in this initial analysis were: How will a field trip to a science research and learning center affect students' desires to learn and participate in science and does interviewing…

  7. Trip Staff Training Practices: Survey and Discussion Results.

    ERIC Educational Resources Information Center

    Zwaagstra, Lynn

    A discussion group and survey examined trip-staff training practices among outdoor and adventure recreation/education programs. Of the 40 participants, 80 percent worked with university noncredit programs, with the remaining participants representing university for-credit, military recreation, nonprofit, and for-profit programs. Although the…

  8. Field Trips as Teaching Tools in the Law Curriculum

    ERIC Educational Resources Information Center

    Higgins, Noelle; Dewhurst, Elaine; Watkins, Los

    2012-01-01

    While field trips are often employed in primary and even second level education as a pedagogical tool, aimed at exposing students to real life experiences, such activities are not as popular at third level (Falk and Balling, 1982; Muse, Chiarelott and Davidman, 1982; Anderson and Zhang, 2003). However, such experiential learning techniques can be…

  9. Using a National Park for a Field Trip

    ERIC Educational Resources Information Center

    Baer, Roy K.

    1977-01-01

    Describes a one-week camping trip to Acadia National Park (Maine) as a non-credit educational experience. Includes activities such as population studies in intertidal zones, wild life sketching, nature list hikes (forest devastation by fire, beaver ponds, glacial ponds and streams), fishing and clamming rips, and student projects. (CS)

  10. A Classical Mnemonic for Older Learners: A Trip That Works

    ERIC Educational Resources Information Center

    Robertson-Tchabo, Elizabeth A.; And Others

    1976-01-01

    A mnemonic procedure, a method of loci, was used with men and women over 60 years old in two studies of free recall. The learners take a mental trip through their residences stopping in order at 16 places. Experimental subjects were able to master the mnemonic and apply it effectively. (Author)

  11. 50 CFR 622.495 - Commercial trip limit.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE FISHERIES OF THE CARIBBEAN, GULF OF MEXICO, AND SOUTH ATLANTIC Queen Conch... trip limit specified in this section taken in the EEZ may not be transferred at sea, regardless of... conch in or from the Caribbean EEZ is 200 queen conch per day....

  12. Tape the Teacher: Easier Field Trips for Large Classes

    ERIC Educational Resources Information Center

    Carter, Lynne; And Others

    1974-01-01

    Describes a tape-guided field trip that has been used successfully with college biology students in the University of California Botanical Garden. This program enables large numbers of students to make individual biological observations in the field with the aid of a specially tailored, taped guide. (JR)

  13. 50 CFR 622.385 - Commercial trip limits.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... a trip limit specified in this section taken in the EEZ may not be transferred at sea, regardless of...., which is a line directly east from the Flagler/Volusia County, FL, boundary, king mackerel in or from... east from the Volusia/Brevard County, FL, boundary, king mackerel in or from the EEZ may not...

  14. Computer simulation of equilibrium conditions following a plant 'trip'

    NASA Astrophysics Data System (ADS)

    Limb, D.

    When a process or part of a process experiences an emergency 'trip', the contained fluids redistribute themselves based upon the prevailing pressure gradients and depending upon the positions of valves at the time of the trip. Reverse flow through rotating compression machinery may occur, depending upon the locations of non-return valves. Reduction in pressure and mixing of cryogenic fluids of different compositions and/or temperatures can both lead to generation of significant volumes of vapour. This equilibration process is usually largely over in a matter of seconds rather than minutes. Key questions facing process and mechanical designers are: what is the settle-out pressure, and can we ensure relief valves do not lift following a trip? To answer these related questions it is necessary to analyse the state of the system prior to the trip, and then, based upon valve positions, etc., construct a model of the worst case probable scenarios for the qualitative redistribution of fluid inventory. At this point the simulation program may be employed to help calculate rigorously the final settle out conditions for each of the possible scenarios. This technique is particularly appropriate for cryogenic processes including refrigeration cycles. It is illustrated here with the help of a multistage hydrocarbon compressor example. Other related non-standard applications of the steady state process simulation program are identified.

  15. Self-Guided Field Trips for Students of Environments

    ERIC Educational Resources Information Center

    Moore, G.; Kerr, Roger; Hadgraft, Roger

    2011-01-01

    In many learning institutions around the world, there is a trend towards larger classes, more flexible learning pathways and reduced teaching resources. Experiential learning is often used in the form of site visits or field trips for students studying engineering, natural resource management, geography and similar disciplines. Providing…

  16. A Trip to Historic Philadelphia on the Web.

    ERIC Educational Resources Information Center

    Wilson, Elizabeth K.

    1997-01-01

    Describes an electronic field trip to colonial Philadelphia (Pennsylvania). The historic locale has generated enough websites (Philadelphia Historic District, Betsy Ross homepage, and the Franklin Institute Science Museum) for students to take a virtual tour of the colonial capital. Suggests structuring the activity as a know-want-learn (KWL)…

  17. The Field Trip Book: Study Travel Experiences in Social Studies

    ERIC Educational Resources Information Center

    Morris, Ronald V.

    2010-01-01

    Looking for social studies adventures to help students find connections to democratic citizenship? Look no further! This book provides just the answer teachers need for engaging students in field trips as researching learners with emphasis on interdisciplinary social studies plus skills in collecting and reporting data gathered from field…

  18. Scalable Domain Decomposed Monte Carlo Particle Transport

    NASA Astrophysics Data System (ADS)

    O'Brien, Matthew Joseph

    In this dissertation, we present the parallel algorithms necessary to run domain decomposed Monte Carlo particle transport on large numbers of processors (millions of processors). Previous algorithms were not scalable, and the parallel overhead became more computationally costly than the numerical simulation. The main algorithms we consider are: • Domain decomposition of constructive solid geometry: enables extremely large calculations in which the background geometry is too large to fit in the memory of a single computational node. • Load Balancing: keeps the workload per processor as even as possible so the calculation runs efficiently. • Global Particle Find: if particles are on the wrong processor, globally resolve their locations to the correct processor based on particle coordinate and background domain. • Visualizing constructive solid geometry, sourcing particles, deciding that particle streaming communication is completed and spatial redecomposition. These algorithms are some of the most important parallel algorithms required for domain decomposed Monte Carlo particle transport. We demonstrate that our previous algorithms were not scalable, prove that our new algorithms are scalable, and run some of the algorithms up to 2 million MPI processes on the Sequoia supercomputer.

  19. Goldschmidt Conference 2005: Field Trip Guide to the Columbia River Basalt Group

    SciTech Connect

    Martin, Barton S.; Petcovic, Heather L.; Reidel, Steve P.

    2005-06-16

    This field trip guide was prepared for the 2005 Goldschmidt Conference held in Moscow, Idaho. The field trip guide provides a two day introduction to the features of the Columbia River Basalt Group in eastern Washington.

  20. Star pinch scalable EUV source

    NASA Astrophysics Data System (ADS)

    McGeoch, Malcolm W.; Pike, Charles T.

    2003-06-01

    A new direct discharge source of 13.5nm radiation addresses the heat load problem by creating the plasma remote from all surfaces. The plasma is initially formed at the intersection of many pulsed xenon beamlets. Further heating is then applied via a high current pulse to induce efficient radiation from Xe10+ ions. The plasma is compact, with a single pulse FWHM diameter of 0.7mm and length of 3mm. It is positionally stable, as illustrated by re-imaging onto a fluorescent screen sensitive to EUV and time-integrating over 250 pulses. In this mode the averaged FWHM is 0.9mm. The conversion efficiency from stored electrical energy to radiation within 2π sterad and 2% bandwidth at 13.5nm is currently 0.55%, using xenon. Power is delivered to the plasma by a solid state-switched modulator operated at a stored energy of 25J of which 10J is dissipated in the plasma plus circuit, and 15J is recovered. The EUV output in 2% bandwidth at 13.5nm is 9mJ/sterad. Repetition rate scaling of the star pinch EUV source to 1kHz there is negligible electrode erosion at 106 pulses. This is possible because the cathode for the main heating discharge is distributed into 24-fold parallel hollow cathodes, with a combined operational surface aera of approximately 20cm2. The anode is similarly distributed. The walls facing the plasma are 22mm distant from it and when scaled to 6kHz will see a heat load of less than 1kWcm-2. The cathode electrode is then expected to receive a heat load of less than 500W cm-2. The plasma is expected to clear between pulses and be reproducible at frequencies up to at least 10kHz, at which rate the usable EUV power available at a second focus, assuming colleciton in 2sterad, is predicted to be more than 80W. The star pinch has properties that favor long life and appears to scale to the 50-100W powers needed for high throughput lithography.

  1. Laplacian embedded regression for scalable manifold regularization.

    PubMed

    Chen, Lin; Tsang, Ivor W; Xu, Dong

    2012-06-01

    Semi-supervised learning (SSL), as a powerful tool to learn from a limited number of labeled data and a large number of unlabeled data, has been attracting increasing attention in the machine learning community. In particular, the manifold regularization framework has laid solid theoretical foundations for a large family of SSL algorithms, such as Laplacian support vector machine (LapSVM) and Laplacian regularized least squares (LapRLS). However, most of these algorithms are limited to small scale problems due to the high computational cost of the matrix inversion operation involved in the optimization problem. In this paper, we propose a novel framework called Laplacian embedded regression by introducing an intermediate decision variable into the manifold regularization framework. By using ∈-insensitive loss, we obtain the Laplacian embedded support vector regression (LapESVR) algorithm, which inherits the sparse solution from SVR. Also, we derive Laplacian embedded RLS (LapERLS) corresponding to RLS under the proposed framework. Both LapESVR and LapERLS possess a simpler form of a transformed kernel, which is the summation of the original kernel and a graph kernel that captures the manifold structure. The benefits of the transformed kernel are two-fold: (1) we can deal with the original kernel matrix and the graph Laplacian matrix in the graph kernel separately and (2) if the graph Laplacian matrix is sparse, we only need to perform the inverse operation for a sparse matrix, which is much more efficient when compared with that for a dense one. Inspired by kernel principal component analysis, we further propose to project the introduced decision variable into a subspace spanned by a few eigenvectors of the graph Laplacian matrix in order to better reflect the data manifold, as well as accelerate the calculation of the graph kernel, allowing our methods to efficiently and effectively cope with large scale SSL problems. Extensive experiments on both toy and real

  2. A scalable infrastructure for CMS data analysis based on OpenStack Cloud and Gluster file system

    NASA Astrophysics Data System (ADS)

    Toor, S.; Osmani, L.; Eerola, P.; Kraemer, O.; Lindén, T.; Tarkoma, S.; White, J.

    2014-06-01

    The challenge of providing a resilient and scalable computational and data management solution for massive scale research environments requires continuous exploration of new technologies and techniques. In this project the aim has been to design a scalable and resilient infrastructure for CERN HEP data analysis. The infrastructure is based on OpenStack components for structuring a private Cloud with the Gluster File System. We integrate the state-of-the-art Cloud technologies with the traditional Grid middleware infrastructure. Our test results show that the adopted approach provides a scalable and resilient solution for managing resources without compromising on performance and high availability.

  3. Using a Field Trip Inventory to Determine If Listening to Elementary School Students' Conversations, While on a Zoo Field Trip, Enhances Preservice Teachers' Abilities to Plan Zoo Field Trips

    NASA Astrophysics Data System (ADS)

    Patrick, Patricia; Mathews, Cathy; Tunnicliffe, Sue Dale

    2013-10-01

    This study investigated whether listening to spontaneous conversations of elementary students and their teachers/chaperones, while they were visiting a zoo, affected preservice elementary teachers' conceptions about planning a field trip to the zoo. One hundred five preservice elementary teachers designed field trips prior to and after listening to students' conversations during a field trip to the zoo. In order to analyze the preservice teachers' field trip designs, we conducted a review of the literature on field trips to develop the field trip inventory (FTI). The FTI focussed on three major components of field trips: cognitive, procedural, and social. Cognitive components were subdivided into pre-visit, during-visit, and post-visit activities and problem-solving. Procedural components included information about the informal science education facility (the zoo) and the zoo staff and included advanced organizers. Social components on student groups, fun, control during the zoo visit, and control of student learning. The results of the investigation showed that (a) the dominant topic in conversations among elementary school groups at the zoo was management, (b) procedural components were mentioned least often, (c) preservice teachers described during-visit activities more often than any other characteristic central to field trip design, (d) seven of the nine characteristics listed in the FTI were noted more frequently in the preservice teachers' field trip designs after they listened to students' conversations at the zoo, and (e) preservice teachers thought that students were not learning and that planning was important.

  4. 78 FR 10556 - Fisheries of the Northeastern United States; Northeast Multispecies Fishery; Trip Limit...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-14

    ... Handgear B (HB) trip limit for GOM and GB cod be adjusted proportionally (rounded up to the nearest 25 lb..., due to a reduced GOM cod sub-ACL for the common pool. Ultimately, the HB trip limit for GOM cod is... A DAS vessels, the new GOM cod trip limit for HB vessels is 200 lb (90.7 kg) per trip (75 lb...

  5. Scalable and sustainable electrochemical allylic C-H oxidation

    NASA Astrophysics Data System (ADS)

    Horn, Evan J.; Rosen, Brandon R.; Chen, Yong; Tang, Jiaze; Chen, Ke; Eastgate, Martin D.; Baran, Phil S.

    2016-05-01

    New methods and strategies for the direct functionalization of C-H bonds are beginning to reshape the field of retrosynthetic analysis, affecting the synthesis of natural products, medicines and materials. The oxidation of allylic systems has played a prominent role in this context as possibly the most widely applied C-H functionalization, owing to the utility of enones and allylic alcohols as versatile intermediates, and their prevalence in natural and unnatural materials. Allylic oxidations have featured in hundreds of syntheses, including some natural product syntheses regarded as “classics”. Despite many attempts to improve the efficiency and practicality of this transformation, the majority of conditions still use highly toxic reagents (based around toxic elements such as chromium or selenium) or expensive catalysts (such as palladium or rhodium). These requirements are problematic in industrial settings; currently, no scalable and sustainable solution to allylic oxidation exists. This oxidation strategy is therefore rarely used for large-scale synthetic applications, limiting the adoption of this retrosynthetic strategy by industrial scientists. Here we describe an electrochemical C-H oxidation strategy that exhibits broad substrate scope, operational simplicity and high chemoselectivity. It uses inexpensive and readily available materials, and represents a scalable allylic C-H oxidation (demonstrated on 100 grams), enabling the adoption of this C-H oxidation strategy in large-scale industrial settings without substantial environmental impact.

  6. The Practice of Prospective Science Teachers regarding the Planning of Education Based Trips: Evaluation of Six Different Field Trips

    ERIC Educational Resources Information Center

    Bozdogan, Aykut Emre

    2012-01-01

    The aim of this study is to explain how planning educational trips out of school environments for training purposes should be as well as to determine the opinions and the practices of prospective science teachers. The study that lasted for two years was carried out in parallel with the elective course "Science Education in Informal Learning…

  7. Getting to Know and Address Your State Science Standards to Connect Classroom Instruction and Field Trips During IYA

    NASA Astrophysics Data System (ADS)

    Bednarski, M.; Larsen, K.

    2008-11-01

    Astronomy activities often pose problems for in-service teachers, especially at the elementary level, as many do not have a solid content background. Often astronomy instruction revolves around reading and answering questions. This is not an effective way to work with abstract concepts or engage students, and also fails to meet the standards of inquiry-based instruction recommended by the National Science Teachers Association and national and state standards. Science museums and planetariums bring unique and exciting perspectives to astronomy education. However, bringing students to the museum can sometimes be perceived as only a ``cool field trip.'' With mounting pressure for teachers to teach to the new standardized tests demanded by No Child Left Behind, and shrinking school budgets, field trips are rapidly becoming an endangered species. Coordinating museum, science center, and planetarium offerings with national and state science standards can renew interest in (and perceived relevance of) field trips. Therefore, university faculty, in-service teachers, and museum/planetarium staff can form successful partnerships which can both improve student learning and increase attendance at informal education science events and facilities. This workshop will first briefly introduce participants to national and representative state standards as well as research on in-service teachers' astronomy content knowledge and the educational value of field trips. For the majority of the workshop, participants will engage in the actual steps of coordinating, planning, and writing inquiry-based astronomy curriculum embedded performance tasks that collectively meet the learning needs of students in elementary, middle, or high school.

  8. Garuda: a scalable tiled display wall using commodity PCs.

    PubMed

    Nirnimesh; Harish, Pawan; Narayanan, P J

    2007-01-01

    Cluster-based tiled display walls can provide cost-effective and scalable displays with high resolution and a large display area. The software to drive them needs to scale too if arbitrarily large displays are to be built. Chromium is a popular software API used to construct such displays. Chromium transparently renders any OpenGL application to a tiled display by partitioning and sending individual OpenGL primitives to each client per frame. Visualization applications often deal with massive geometric data with millions of primitives. Transmitting them every frame results in huge network requirements that adversely affect the scalability of the system. In this paper, we present Garuda, a client-server-based display wall framework that uses off-the-shelf hardware and a standard network. Garuda is scalable to large tile configurations and massive environments. It can transparently render any application built using the Open Scene Graph (OSG) API to a tiled display without any modification by the user. The Garuda server uses an object-based scene structure represented using a scene graph. The server determines the objects visible to each display tile using a novel adaptive algorithm that culls the scene graph to a hierarchy of frustums. Required parts of the scene graph are transmitted to the clients, which cache them to exploit the interframe redundancy. A multicast-based protocol is used to transmit the geometry to exploit the spatial redundancy present in tiled display systems. A geometry push philosophy from the server helps keep the clients in sync with one another. Neither the server nor a client needs to render the entire scene, making the system suitable for interactive rendering of massive models. Transparent rendering is achieved by intercepting the cull, draw, and swap functions of OSG and replacing them with our own. We demonstrate the performance and scalability of the Garuda system for different configurations of display wall. We also show that the

  9. 49 CFR 236.531 - Trip arm; height and distance from rail.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Trip arm; height and distance from rail. 236.531... Train Stop, Train Control and Cab Signal Systems Rules and Instructions; Roadway § 236.531 Trip arm; height and distance from rail. Trip arm of automatic train stop device when in the stop position shall...

  10. 49 CFR 236.531 - Trip arm; height and distance from rail.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Trip arm; height and distance from rail. 236.531... Train Stop, Train Control and Cab Signal Systems Rules and Instructions; Roadway § 236.531 Trip arm; height and distance from rail. Trip arm of automatic train stop device when in the stop position shall...

  11. 49 CFR 236.531 - Trip arm; height and distance from rail.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Trip arm; height and distance from rail. 236.531... Train Stop, Train Control and Cab Signal Systems Rules and Instructions; Roadway § 236.531 Trip arm; height and distance from rail. Trip arm of automatic train stop device when in the stop position shall...

  12. 49 CFR 236.531 - Trip arm; height and distance from rail.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Trip arm; height and distance from rail. 236.531... Train Stop, Train Control and Cab Signal Systems Rules and Instructions; Roadway § 236.531 Trip arm; height and distance from rail. Trip arm of automatic train stop device when in the stop position shall...

  13. 49 CFR 236.531 - Trip arm; height and distance from rail.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Trip arm; height and distance from rail. 236.531... Train Stop, Train Control and Cab Signal Systems Rules and Instructions; Roadway § 236.531 Trip arm; height and distance from rail. Trip arm of automatic train stop device when in the stop position shall...

  14. Questionnaire-based person trip visualization and its integration to quantitative measurements in Myanmar

    NASA Astrophysics Data System (ADS)

    Kimijiama, S.; Nagai, M.

    2016-06-01

    With telecommunication development in Myanmar, person trip survey is supposed to shift from conversational questionnaire to GPS survey. Integration of both historical questionnaire data to GPS survey and visualizing them are very important to evaluate chronological trip changes with socio-economic and environmental events. The objectives of this paper are to: (a) visualize questionnaire-based person trip data, (b) compare the errors between questionnaire and GPS data sets with respect to sex and age and (c) assess the trip behaviour in time-series. Totally, 345 individual respondents were selected through random stratification to assess person trip using a questionnaire and GPS survey for each. Conversion of trip information such as a destination from the questionnaires was conducted by using GIS. The results show that errors between the two data sets in the number of trips, total trip distance and total trip duration are 25.5%, 33.2% and 37.2%, respectively. The smaller errors are found among working-age females mainly employed with the project-related activities generated by foreign investment. The trip distant was yearly increased. The study concluded that visualization of questionnaire-based person trip data and integrating them to current quantitative measurements are very useful to explore historical trip changes and understand impacts from socio-economic events.

  15. Africana Acquisitions; Report of a Publication Survey Trip to Nigeria, Southern Africa, and Europe, 1972.

    ERIC Educational Resources Information Center

    Witherell, Julian W.

    A publication survey trip to Nigeria, Southern Africa, and Europe was taken by Julian W. Witherell of the African Section of the Library of Congress in 1972. The purpose of the trip was to improve the flow of publications about Africa to the Library of Congress. The trip was successful in that personal contacts helpful in obtaining local materials…

  16. Guide to Canoe Camping. A Comprehensive Planning Guide for Canoe Trip Leaders.

    ERIC Educational Resources Information Center

    Johnstone, D. Bruce

    A canoe camping trip offers an exciting, inexpensive vacation from the usual daily routine and environment, and develops resourcefulness, cooperation, and camaraderie among participants. Chapter 1 of this guide discusses preliminary planning of a canoe trip, including decisions on the length and type of trip, designation of a leader for large…

  17. 49 CFR 236.560 - Contact element, mechanical trip type; location with respect to rail.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Contact element, mechanical trip type; location... Instructions; Locomotives § 236.560 Contact element, mechanical trip type; location with respect to rail. Contact element of automatic train stop device of the mechanical trip type shall be maintained at a...

  18. 49 CFR 236.560 - Contact element, mechanical trip type; location with respect to rail.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Contact element, mechanical trip type; location... Instructions; Locomotives § 236.560 Contact element, mechanical trip type; location with respect to rail. Contact element of automatic train stop device of the mechanical trip type shall be maintained at a...

  19. 49 CFR 236.560 - Contact element, mechanical trip type; location with respect to rail.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Contact element, mechanical trip type; location... Instructions; Locomotives § 236.560 Contact element, mechanical trip type; location with respect to rail. Contact element of automatic train stop device of the mechanical trip type shall be maintained at a...

  20. 49 CFR 236.560 - Contact element, mechanical trip type; location with respect to rail.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Contact element, mechanical trip type; location... Instructions; Locomotives § 236.560 Contact element, mechanical trip type; location with respect to rail. Contact element of automatic train stop device of the mechanical trip type shall be maintained at a...