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Sample records for hindamise ning teenuse

  1. Ning and Writing to Learn

    ERIC Educational Resources Information Center

    Ettzevoglou, Nathalie; McBride, Jessica

    2009-01-01

    Writing effectively is academically and professionally crucial for students, and helping them attain that skill is a major goal for writing instruction. The social networking site Ning offers a variety of Web 2.0 tools that can help students learn to write as well as write to learn. In this article, the authors describe their personal experiment…

  2. Educators Eye Ning Transition to a Pay Model

    ERIC Educational Resources Information Center

    Davis, Michelle R.

    2010-01-01

    The author reports on a move by the online social-networking site Ning to start charging for its services which has raised worries that new fees could stifle educators' technological collaboration and creativity and touch off similar moves by other companies that provide comparable services heavily used by educators. Ning, which provides a…

  3. 75 FR 337 - Action Affecting Export Privileges: Ning Wen

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-05

    ... Doc No: E9-31367] DEPARTMENT OF COMMERCE Bureau of Industry and Security [07-BIS-02] Action Affecting... Ning Wen The Bureau of Industry and Security, U.S. Department of Commerce (``BIS'') has initiated an...: 15 CFR 764.2(d)--Conspiracy To Export Electronic Components to People's Republic of China Without...

  4. Beauty and physics: 13 important contributions of Chen Ning Yang

    NASA Astrophysics Data System (ADS)

    Shi, Yu

    2014-06-01

    In 2012, Chen Ning Yang received a 90th birthday gift in the form of a black cube inscribed with his 13 most important contributions, which cover four major areas of physics: statistical mechanics, condensed matter physics, particle physics and field theory. We briefly describe these 13 contributions and make general comments about Yang's distinctive style as a trailblazing leader in research.

  5. Bu-Shen-Ning-Xin decoction suppresses osteoclastogenesis via increasing dehydroepiandrosterone to prevent postmenopausal osteoporosis.

    PubMed

    Gui, Yuyan; Qiu, Xuemin; Xu, Yingping; Li, Dajin; Wang, Ling

    2015-06-01

    Bu-Shen-Ning-Xin decoction (BSNXD), a traditional Chinese medicine, has been used to prevent and treat age-related diseases such as postmenopausal osteoporosis (PMO) for decades. This study sought to investigate the underlying mechanisms of BSNXD in terms of receptor activation of nuclear factor κB ligand (RANKL)-induced osteoclastogenesis in vitro because of the critical roles of bone resorption in the development and progression of osteoporosis. In mice, serum levels of dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), and 17-β-estradiol (E2) were evaluated with an enzyme immunoassay kit after ovariectomy. Levels of DHEA and DHEAS increased significantly following administration of BSNXD while the level of E2 did not. In addition, tartrate-resistance acid phosphatase staining showed that DHEA profoundly inhibited RANKL-induced osteoclastogenesis in vitro in a dose-dependent manner via estrogen receptor α (ERα) but not via estrogen receptor β or androgen receptors. Cytotoxicity was not detected in the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. These data suggest that BSNXD prevents PMO by increasing DHEA via the ERαpathway to suppress osteoclastogenesis.

  6. Tang-Luo-Ning Improves Mitochondrial Antioxidase Activity in Dorsal Root Ganglia of Diabetic Rats: A Proteomics Study

    PubMed Central

    Gao, Yanbin; Gong, Yanbin; Zhou, Hui; Xie, Peifeng; Guan, Song; Yi, Wenming

    2017-01-01

    Tang-luo-ning (TLN) is a traditional Chinese herbal recipe for treating diabetic peripheral neuropathy (DPN). In this study, we investigated mitochondrial protein profiles in a diabetic rat model and explored the potential protective effect of TLN. Diabetic rats were established by injection of streptozocin (STZ) and divided into model, alpha lipoic acid (ALA), and TLN groups. Mitochondrial proteins were isolated from dorsal root ganglia and proteomic analysis was used to quantify the differentially expressed proteins. Tang-luo-ning mitigated STZ-induced diabetic symptoms and blood glucose level, including response time to cold or hot stimulation and nerve conductive velocity. As compared to the normal, there were 388 differentially expressed proteins in the TLN group, 445 in ALA group, and 451 in model group. As compared to the model group, there were 275 differential proteins in TLN group and 251 in ALA group. As compared to model group, mitochondrial complex III was significantly decreased, while glutathione peroxidase and peroxidase were increased in TLN group. When compared with ALA group, the mitochondrial complex III was increased, and mitochondrial complex IV was decreased in TLN group. Together, TLN should have a strong antioxidative activity, which appears to be modulated through regulation of respiratory complexes and antioxidases. PMID:28133612

  7. Pharmacodynamics and potential synergistic effects of Mai-Luo-Ning injection on cardiovascular protection, based on molecular docking.

    PubMed

    Wu, Liang; Shen, Han-Yuan; Wu, Yu-Zheng; Yu, Xiao-Yi; Wang, Hong; Cheng, Xue-Fang; Wang, Guang-Ji; Hao, Hai-Ping

    2015-11-01

    As a computer-assisted approach, molecular docking has been universally applied in drug research and development and plays an important role in the investigation and evaluation of herbal medicines. Herein, the method was used to estimate the pharmacodynamics of Mai-Luo-Ning injection, a traditional Chinese compound herbal prescription. Through investigating the interactions between several important proteins in cardiovascular system and characteristic components of the formula, its effect on cardiovascular protection was evaluated. Results showed the differences in the interactions between each component and the selected target proteins and revealed the possible mechanisms for synergistic effects of various characteristic components on cardiovascular protection. The study provided scientific evidence supporting the mechanistic study of the interactions among multi-components and targets, offering a general approach to investigating the pharmacodynamics of complicated materials in compound herbal prescriptions.

  8. Effects of Bu-Shen-Ning-Xin Decoction on immune cells of the spleen and bone marrow in ovariectomized mice.

    PubMed

    Qiu, Xuemin; Gui, Yuyan; Zhang, Na; Xu, Yingping; Li, Dajin; Wang, Ling

    2016-11-15

    Osteoimmunology is a new discipline that focuses on the interaction between the bones and the immune system. Immune cells play an important role in bone metabolism. The aim of this study was to illustrate the effect of Bu-Shen-Ning-Xin Decoction (BSNXD) on lymphocytes in the spleen and bone marrow to explore the potential role on the bone. C57BL/6 mice were divided into four groups: sham, ovariectomized (OVX), OVX+BSNXD, and OVX+ estrogen. The sham and OVX groups were treated with saline, the OVX+BSNXD group was treated with BSNXD, and the OVX+ estrogen group was treated with estrogen. After mice were sacrificed, the spleens and bones were collected, and the lymphocytes in the spleen and bone marrow were analyzed. We found that BSNXD lessened the extent of the increase of CD4(+) and bone marrow. In contrast, these numbers were both increased in the OVX group. BSNXD had no influence on the percentage of γδ T cells. However, it increased the proportion of NK cells in the spleen and bone marrow. BSNXD lessened the extent of the increase of monocytes by ovariectomy. In vitro experiment, we found Tregs can decrease osteoclastogenesis when co-cultured with osteoclast precursor cells. This study suggests that BSNXD changes the immune environment and immune cells have a role in bone metabolism in OVX mice.

  9. Research on the change of chemical composition in productive process of Re Du Ning injection by HPLC/Q-TOF MS.

    PubMed

    Zhang, Shan; Li, Yan-Jing; Zhang, Chun-Xiao; Huang, Wen-Zhe; Ding, Gang; Wang, Zhen-Zhong; Bi, Yu-An; Xiao, Wei

    2016-02-01

    A high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC/Q-TOF MS) was developed for the analysis of chemical composition change in the production process of Re Du Ning injection, a Chinese medicine preparation with a combination of Lonicera japonica Thunb., Gardenia jasminoides Ellis and Artemisia annua L. A total of 90 compounds from raw materials-intermediates-Re Du Ning injection were detected; among them, 55 compounds were identified or tentatively characterized, and the characteristic ions of different types of compounds were described. Based on these studies, the different types of compounds in the various process routes were analyzed. A total of 28 compounds, including seven iridoid glycosides and six monoterpenes from G. jasminoides Ellis, five iridoid glycosides, nine phenolic acids and one unknown compound from L. japonica Thunb., were transferred to Re Du Ning injection, and two unknown compounds were generated in the production process of Re Du Ning injection. The results indicated that the Chinese Medicine Pharmaceutical process control is very important. This method could provide some reference for other Chinese medicine preparations.

  10. IRon Overload screeNing tool (IRON): development of a tool to guide screening in primary care.

    PubMed

    Mainous, Arch G; Diaz, Vanessa A; Everett, Charles J; Knoll, Michele E; Hulihan, Mary M; Grant, Althea M; McLaren, Christine E; McLaren, Gordon D

    2011-09-01

    Iron overload is associated with significant morbidity and mortality yet is easily treated. The objective of this study was to create a tool that could be easily adapted to clinical practice that indicates the likelihood of a patient having undetected iron overload. We used the National Health and Nutrition Examination Survey (NHANES) 1999-2002 for US adults aged 20 years and older to build a model (unweighted n=8,779). We chose potential variables for inclusion that could be gathered by self-report or measured without laboratory data and were suggested by past literature on hemochromatosis and iron overload. We computed logistic regressions to create the scores by initially evaluating the variables' relationship with elevated ferritin and elevated transferrin saturation and then using odds ratios to correspond to scores. The resulting score on the IRon Overload ScreeNing Tool (IRON) was then validated with data on 13,844 adults in the NHANES III, 1988-94. Predictors in the final tool were age, gender, previous diagnoses of liver condition, osteoporosis or thyroid disease. The IRON score yielded an area under the curve (AUC) in the NHANES 1999-02 of 0.720 and an AUC of 0.685 in the NHANES III validation sample. The IRON score is a tool to assist in identification of patients with iron overload that has several qualities that make it attractive for use in clinical practice with an undifferentiated patient population including brevity, easily collected information and predictive ability comparable to other tools that help in directing screening.

  11. Screening anaphylactic components of MaiLuoNing injection by using rat basophilic leukemia-2H3 cell membrane chromatography coupled with HPLC-ESI-TOF-MS.

    PubMed

    Han, Shengli; Lv, Yanni; Xue, Wenjing; Cao, Jiao; Cui, Ronghua; Zhang, Tao

    2016-02-01

    MaiLuoNing injection is a traditional Chinese medicine that used clinically since the 1950s in China. However, anaphylactic reactions, through the potentiation of mast cell degranulation, have been reported. In the present study, a rat basophilic leukemia-2H3 cell membrane chromatography coupled with high-performance liquid chromatography and electrospray ionization-ion trap-time of flight-mass spectrometry method was established for screening, analyzing, and identifying the potential anaphylactic components of MaiLuoNing injection. Harpagoside, a potential degranulator of rat basophilic leukemia-2H3 cells, was retained in rat basophilic leukemia-2H3 cell membrane chromatography. We aimed to evaluate the retained components to determine which of those were capable of inducing degranulation of basophilic leukemia cells. A β-hexosaminidase assay revealed that harpagoside can induce rat basophilic leukemia-2H3 cell degranulation in a dose-dependent manner. BLBA/c mice also exhibit passive cutaneous anaphylaxis in response to harpagoside. These results indicate that rat basophilic leukemia-2H3 cell membrane chromatography coupled with high-performance liquid chromatography and electrospray ionization ion trap time-of-flight mass spectrometry is effective in screening for the anaphylactic components of MaiLuoNing injection.

  12. L'hémangiopéricytome méningé: une tumeur intracrânienne rare - à propos d'un cas

    PubMed Central

    Errachdi, Amal; Asabbane, Amal; Epala, Brice Nkoua; Hemmich, Mariem; Kabbali, Naoual; Diakité, Adama; Kebdani, Tayeb; Benjaafar, Noureddine

    2014-01-01

    L'hémangiopéricytomeméningé intracrânien est une tumeur rare qui représente moins de 1% des tumeurs cérébrales. Son aspect radiologique peut être trompeur et faire porter à tort le diagnostic de méningiome. Le diagnostic de confirmation est histologique. Le traitement repose sur la chirurgie et la radiothérapie. L’évolution après traitement est caractérisée par la fréquence des récidives et des métastases à distance, imposant un suivi prolongé. Nous rapportons l'observation d'un patient présentant un hémangiopéricytome intracrânien dont l’évolution était marquée par l'absence de récidive à 4 ans de suivi. PMID:25170367

  13. Bu-Shen-Ning-Xin Decoction ameliorated the osteoporotic phenotype of ovariectomized mice without affecting the serum estrogen concentration or uterus

    PubMed Central

    Wang, Ling; Qiu, Xue-Min; Gui, Yu-Yan; Xu, Ying-Ping; Gober, Hans-Jürgen; Li, Da-Jin

    2015-01-01

    Introduction Bu-Shen-Ning-Xin Decoction (BSNXD), a traditional Chinese medicinal composition, has been used as a remedy for postmenopausal osteoporosis, but its effects on bone metabolism and the uterus have not been reported. Purpose We aimed to determine the respective effects of BSNXD on the bones and the uterus of ovariectomized (OVX) mice to evaluate the efficacy and safety of this herbal formula. Materials and methods Postmenopausal osteoporosis animal models that were generated by ovariectomy were treated with BSNXD. Dual-energy X-ray absorptiometry was performed to analyze the bone mineral density, and histomorphometric analysis was performed to measure the parameters related to bone metabolism. Calcein labeling was performed to detect bone formation. The uteruses from the mice were weighed, and the histomorphometry was analyzed. Drug-derived serum was prepared to assess the 17-β-estradiol concentration via enzyme immunoassay. Results BSNXD administration ameliorated the osteoporotic phenotype of OVX mice, as evidenced by an increase in the bone mineral density and bone volume; these effects could not be abolished by the administration of the aromatase inhibitor letrozole. Moreover, BSNXD had no effect on the serum estrogen concentration or uterus. Conclusion These results suggest that BSNXD has ameliorating effects on bone loss due to estrogen deprivation without affecting the peripheral blood estrogen concentration or the uterus in OVX mice. PMID:26357466

  14. Multiscale Modeling of Drug-induced Effects of ReDuNing Injection on Human Disease: From Drug Molecules to Clinical Symptoms of Disease

    NASA Astrophysics Data System (ADS)

    Luo, Fang; Gu, Jiangyong; Zhang, Xinzhuang; Chen, Lirong; Cao, Liang; Li, Na; Wang, Zhenzhong; Xiao, Wei; Xu, Xiaojie

    2015-05-01

    ReDuNing injection (RDN) is a patented traditional Chinese medicine, and the components of it were proven to have antiviral and important anti-inflammatory activities. Several reports showed that RDN had potential effects in the treatment of influenza and pneumonia. Though there were several experimental reports about RDN, the experimental results were not enough and complete due to that it was difficult to predict and verify the effect of RDN for a large number of human diseases. Here we employed multiscale model by integrating molecular docking, network pharmacology and the clinical symptoms information of diseases and explored the interaction mechanism of RDN on human diseases. Meanwhile, we analyzed the relation among the drug molecules, target proteins, biological pathways, human diseases and the clinical symptoms about it. Then we predicted potential active ingredients of RDN, the potential target proteins, the key pathways and related diseases. These attempts may offer several new insights to understand the pharmacological properties of RDN and provide benefit for its new clinical applications and research.

  15. Impact of parameter fluctuations on the performance of ethanol precipitation in production of Re Du Ning Injections, based on HPLC fingerprints and principal component analysis.

    PubMed

    Sun, Li-Qiong; Wang, Shu-Yao; Li, Yan-Jing; Wang, Yong-Xiang; Wang, Zhen-Zhong; Huang, Wen-Zhe; Wang, Yue-Sheng; Bi, Yu-An; Ding, Gang; Xiao, Wei

    2016-01-01

    The present study was designed to determine the relationships between the performance of ethanol precipitation and seven process parameters in the ethanol precipitation process of Re Du Ning Injections, including concentrate density, concentrate temperature, ethanol content, flow rate and stir rate in the addition of ethanol, precipitation time, and precipitation temperature. Under the experimental and simulated production conditions, a series of precipitated resultants were prepared by changing these variables one by one, and then examined by HPLC fingerprint analyses. Different from the traditional evaluation model based on single or a few constituents, the fingerprint data of every parameter fluctuation test was processed with Principal Component Analysis (PCA) to comprehensively assess the performance of ethanol precipitation. Our results showed that concentrate density, ethanol content, and precipitation time were the most important parameters that influence the recovery of active compounds in precipitation resultants. The present study would provide some reference for pharmaceutical scientists engaged in research on pharmaceutical process optimization and help pharmaceutical enterprises adapt a scientific and reasonable cost-effective approach to ensure the batch-to-batch quality consistency of the final products.

  16. Atteinte cérébro-méningée multiple révélant une Tuberculose multifocale chez un immunocompétent

    PubMed Central

    Boulahri, Tarik; Taous, Abdellah; Berri, Maha Aït; Traibi, Imane; Rouimi, Abdelhadi

    2016-01-01

    La Tuberculose constitue un problème de santé publique au Maroc. L’atteinte du système nerveux central est néanmoins rare, survenant dans un contexte de tuberculose multifocale ou miliaire tuberculeuse. Cependant elle peut être un mode de révélation même chez un sujet immunocompétent. Nous rapportons le cas d’un homme de 30 ans qui avait présenté un trouble du langage évoluant dans un contexte d’altération de l’état général avec à l’examen clinique une aphasie motrice de type Broca, un syndrome pyramidal latéralisé à droite et des adénopathies latéro-cérvicales. la sérologie HIV était négative. L’IRM cérébrale: montrait des lésions associant des tuberculomes intracrâniens multiple et une image de méningo-encéphalite. La TDM thoracique montrait de multiples micronodules pulmonaires, une image cavitaire à paroi épaissie et DDB du fowler droit et du culmen. La biopsie des ganglions lymphatiques révélait la présence de granulome typique de tuberculose. Le diagnostic de tuberculose multifocale fut retenu et le patient fut mis sous traitement anti-bacillaire associé à une corticothérapie avec une bonne évolution clinico-radiologique. Cette observation est particulière par l’aspect et le siège des lésions tuberculeuse retrouvées à l’imagerie cérébrale, par l’absence d’immunodéficience, par la bonne évolution sous traitement et souligne l’intérêt de rechercher activement par un bilan exhaustif une infection tuberculeuse extra-cérébrale associée devant toute lésion cérébro-méningée évocatrice de tuberculose. PMID:28293347

  17. Hémorragie méningée et hématome parenchymateux révélant une thrombose veineuse cérébrale

    PubMed Central

    Joulali, Toufik; Derkaoui, Ali; Besri, Sophia; Malki, Mohammed; Shimi, Abdelkarim; Khatouf, Mohammed

    2015-01-01

    La thrombophlébite cérébrale (TVC) est une cause non négligeable des accidents vasculaires cérébraux avec une grande diversité de leur présentation Clinique source d'errance et de retard thérapeutique. Nous rapportons l'observation d'une patiente présentant une TVC révélée par une hémorragie méningée. Le diagnostic a été suspecté à l'artériographie réalisée dans le cadre du bilan étiologique et thérapeutique de l'hémorragie méningée et confirmé par la suite sur l'angio-scanner. La particularité de cette observation est la difficulté aussi bien diagnostique de la TVC et sa révélation par une hémorragie méningée, que thérapeutique concernant l'utilisation des anticoagulants. PMID:26161216

  18. Un syndrome malin des neuroleptiques compliqué d'hémorragie méningée et révélant une vascularite cérébrale

    PubMed Central

    Jouali, Toufik; Boukatta, Brahim; Bechri, Brahim; Houari, Nawfel; Bouazzaoui, Abderahim; Sbai, Hicham; Kanjaa, Nabil

    2014-01-01

    Le syndrome malin des neuroleptiques est une complication du traitement par les neuroleptiques. Son incidence est estimée à 0,02% dans la population générale. Le traitement reste symptomatique et repose essentiellement sur l'arrêt immédiat du traitement antérieur. Nous rapportons l'observation clinique d'une patiente de 26 ans, schizophrénique sous Chlorpromazine, se présentant aux urgences pour la prise en charge d'un syndrome malin des neuroleptiques compliqué d'une hémorragie méningée et révélant une vascularite cérébrale. PMID:25852790

  19. Bu-Shen-Ning-Xin decoction: inhibition of osteoclastogenesis by abrogation of the RANKL-induced NFATc1 and NF-κB signaling pathways via selective estrogen receptor α

    PubMed Central

    Wang, Ling; Qiu, Xue-Min; Gui, Yu-Yan; Xu, Ying-Ping; Gober, Hans-Jürgen; Li, Da-Jin

    2015-01-01

    Introduction Bu-Shen-Ning-Xin decoction (BSNXD) is a traditional Chinese medicinal composition that has been used as a remedy for postmenopausal osteoporosis, but the mechanisms affecting bone metabolism are not fully understood. Purpose We investigated the molecular mechanism and signaling pathway underlying the effect of BSNXD on osteoclastogenesis. Materials and methods A postmenopausal osteoporosis animal model generated by ovariectomy was administered BSNXD and drug-derived serum was prepared. An enzyme immunoassay was conducted to measure the 17-β-estradiol (E2) concentration in the drug-derived serum. Bone marrow-derived monocyte/macrophage precursor cells were treated with drug-derived serum, and tartrate-resistance acid phosphatase staining was conducted to observe osteoclastogenesis. A bone resorption assay was performed to analyze the effect on osteoclastic resorptive function. Real-time PCR, flow cytometry, Western blotting, transfection, and luciferase assays were conducted to explore the related mechanism. Results E2 was not elevated in BSNXD-derived serum. BSNXD-derived serum suppressed receptor activation of nuclear factor κB ligand (RANKL)-activated osteoclastogenesis in a dose-dependent manner; this effect could be reversed by estrogen receptor α antagonist methyl-piperidino-pyrazole. The serum suppressed RANKL-induced NF-κB transcription and inhibited the accumulation of nuclear factor of activated T-cells, cytoplasmic 1 in osteoclast precursor cells; the inhibitory effect was abolished by methyl-piperidino-pyrazole but not the estrogen receptor β antagonist or androgen receptor antagonist. Conclusion These results collectively suggest that administration of BSNXD presents inhibitory effects on osteoclast differentiation by abrogating the RANKL-induced nuclear factor of activated T-cells, cytoplasmic 1 and NF-κB signaling pathways downstream of estrogen receptor α, thereby contributing to the inhibitory effect on bone resorption. PMID

  20. Combination of counterpropagation artificial neural networks and antioxidant activities for comprehensive evaluation of associated-extraction efficiency of various cyclodextrins in the traditional Chinese formula Xue-Zhi-Ning.

    PubMed

    Sun, Lili; Yang, Jianwen; Wang, Meng; Zhang, Huijie; Liu, Yanan; Ren, Xiaoliang; Qi, Aidi

    2015-11-10

    Xue-Zhi-Ning (XZN) is a widely used traditional Chinese medicine formula to treat hyperlipidemia. Recently, cyclodextrins (CDs) have been extensively used to minimize problems relative to medicine bioavailability, such as low solubility and poor stability. The objective of this study was to determine the associated-extraction efficiency of various CDs in XZN. Three various type CDs were evaluated, including native CDs (α-CD, β-CD), hydrophilic CD derivatives (HP-β-CD and Me-β-CD), and ionic CD derivatives (SBE-β-CD and CM-β-CD). An ultra high-performance liquid chromatography (UHPLC) fingerprint was applied to determine the components in CD extracts and original aqueous extract (OAE). A counterpropagation artificial neural network (CP-ANN) was used to analyze the components in different extracts and compare the selective extraction of various CDs. Extraction efficiencies of the various CDs in terms of extracted components follow the ranking, ionic CD derivatives>hydrophilic CD derivatives>native CDs>OAE. Besides, different types of CDs have their own selective extraction and ionic CD derivatives present the strongest associated-extraction efficiency. Antioxidant potentials of various extracts were evaluated by determining the inhibition of spontaneous, H2O2-induced, CCl4-induced and Fe(2+)/ascorbic acid-induced lipid peroxidation (LPO) and analyzing the scavenging capacity for DPPH and hydroxyl radicals. The order of extraction efficiencies of the various CDs relative to antioxidant activities is as follows: SBE-β-CD>CM-β-CD>HP-β-CD>Me-β-CD>β-CD>α-CD. It can be demonstrated that all of the CDs studied increase the extraction efficiency and that ionic CD derivatives (SBE-β-CD and CM-β-CD) present the highest extraction capability in terms of amount extracted and antioxidant activities of extracts.

  1. Manifestations neuropsychiatriques révélant une hémorragie cérébro-méningée causée par un accident d’électrisation: à propos d'une observation et revue de la literature

    PubMed Central

    Bugeme, Marcellin; Mukuku, Olivier

    2014-01-01

    Le courant électrique est susceptible de léser tout tissu de l'organisme rencontré lors de son passage, de manière transitoire ou définitive. Les hémorragies cérébro-méningées secondaires à un accident d’électrisation par courant électrique à haute tension sont très rarement rapportées dans la littérature. Nous rapportons un cas d'hémorragie cérébro-méningée révélée par des manifestations neuropsychiatriques causée par un AE par courant électrique à haute tension observée chez un enfant âgé de 6 ans à Lubumbashi, en République Démocratique du Congo. La particularité que présente notre observation est les manifestations neuropsychiatriques observées tardivement. PMID:25419328

  2. Réponse radiologique complète d'un hémangiopéricytome méningé après radiothérapie adjuvante à une exérèse incomplète

    PubMed Central

    Bazine, Amine; Ogandaga, Etienne; Dossou, Serpos; Aissa, Abdellah; Oumellal, Jamal; Lalya, Issam; Saidi, Amar; Kebdani, Tayeb; Benjaafar, Noureddine

    2014-01-01

    L'hémangiopéricytome méningé (HM) est une tumeur vasculaire rare qui représente moins de 1% des tumeurs intracrâniennes. Son traitement reste à ce jour mal codifié et n'est basé que sur des données rétrospectives. La place de la radiothérapie adjuvante après chirurgie d'exérèse n'est pas bien établie. Ce présent travail décrit un cas d'HM chez une patiente de 42 ans, traité par chirurgie incomplète et radiothérapie adjuvante, avec réponse radiologique complète notée 1 an après la fin du traitement. PMID:25379118

  3. Defining Moments \\ di-'fi-ning 'mo-mnts \\

    ERIC Educational Resources Information Center

    Kilman, Carrie

    2012-01-01

    Children encounter new words every day. Although dictionaries designed for young readers can help students explore and experiment with language, it turns out many mainstream children's dictionaries fail to accurately describe the world in which many students live. The challenges to children's dictionary publishers can be steep. First, there is the…

  4. Process Writing and the Internet: Blogs and Ning Networks in the Classroom

    ERIC Educational Resources Information Center

    Boas, Isabela Villas

    2011-01-01

    In contrast to the product approach to writing, which is based on studying and replicating textual models, the process approach involves multiple and repeated steps that compel the writer to closely consider the topic, language, purpose for writing, and social reality of an audience. In addition to discussing the benefits of the process approach…

  5. Development and Evaluation of Ning Social Network for Teaching Training Online Surveillance

    ERIC Educational Resources Information Center

    Mohd Nawi, Mohd Aliff; Jamsari, Ezad Azraai; Sulaiman, Adibah; Hamzah, Mohd Isa

    2013-01-01

    Supervision of teaching practice is an important aspect of training teachers in improving their teaching skills. Barriers such as distance and time factor are the constraints faced by the lecturers at the National University of Malaysia to communicate with the teacher trainees under their supervision. Therefore, this study aims to develop and…

  6. Tailoring Pore Size of Nitrogen-Doped Hollow Carbon Nanospheres for Confi ning Sulfur in Lithium–Sulfur Batteries

    SciTech Connect

    Zhou, Weidong; Wang, Chong M.; Zhang, Quiglin; Abruna, Hector D.; He, Yang; Wang, Jiangwei; Mao, Scott X.; Xiao, Xingcheng

    2015-08-19

    Three types of nitrogen-doped hollow carbon spheres with different pore sized porous shells are prepared to investigate the performance of sulfur confinement. The reason that why no sulfur is observed in previous research is determined and it is successfully demonstrated that the sulfur/polysulfide will overflow the porous carbon during the lithiation process.

  7. Kone Ja Keele Uurimine Ning Emakeele Didaktika (Relevance of Linguistic and Psycholinguistic Studies to Mother Tongue Instruction).

    ERIC Educational Resources Information Center

    Karlep, Karl

    This article looks at the relevance of linguistic and psycholinguistic studies to mother tongue instruction. Particularly, the semantically-oriented research of higher level units of language and speech, is considered. As some Estonian studies imply, there are indications that the application of psycholinguistic research in teaching practices…

  8. The Use of Alternative Social Networking Sites in Higher Educational Settings: A Case Study of the E-Learning Benefits of Ning in Education

    ERIC Educational Resources Information Center

    Brady, Kevin P.; Holcomb, Lori B.; Smith, Bethany V.

    2010-01-01

    Distance education as a primary means of instruction is expanding significantly at the college and university level. Simultaneously, the growth of social networking sites (SNS) including Facebook, LinkedIn, and MySpace is also rising among today's college students. An increasing number of higher education instructors are beginning to combine…

  9. Social Networking Services in E-Learning

    ERIC Educational Resources Information Center

    Weber, Peter; Rothe, Hannes

    2016-01-01

    This paper is a report on the findings of a study conducted on the use of the social networking service NING in a cross-location e-learning setting named "Net Economy." We describe how we implemented NING as a fundamental part of the setting through a special phase concept and team building approach. With the help of user statistics, we…

  10. DAWN: Dynamic Ad-hoc Wireless Network

    DTIC Science & Technology

    2016-06-19

    none) (c) Presentations 03/15/2007 03/15/2007 27.00 28.00 Received Paper Ning Li, Jennifer C. Hou. A Scalable, Power-Efficient Broadcast Algorithm for...Wireless Networks, , ( ): . doi: Ning Li, Jennifer C. Hou. Localized Topology Control Algorithms for Heterogeneous Wireless Networks, IEEE

  11. Social Networking Services in E-Learning

    ERIC Educational Resources Information Center

    Weber, Peter; Rothe, Hannes

    2012-01-01

    This paper is a report on the findings of a study conducted on the use of the social networking service NING in a cross-location e-learning setting named "Net Economy." We describe how we implemented NING as a fundamental part of the setting through a special phase concept and team building approach. With the help of user statistics, we examine…

  12. Enhancing Classroom Effectiveness through Social Networking Tools

    ERIC Educational Resources Information Center

    Kurthakoti, Raghu; Boostrom, Robert E., Jr.; Summey, John H.; Campbell, David A.

    2013-01-01

    To determine the usefulness of social networking Web sites such as Ning.com as a communication tool in marketing courses, a study was designed with special concern for social network use in comparison to Blackboard. Students from multiple marketing courses were surveyed. Assessments of Ning.com and Blackboard were performed both to understand how…

  13. Revisiting COIN Theory and Instruction

    DTIC Science & Technology

    2009-03-13

    because he believed that there was plenty of research on insurgencies but not nearly enough on how to fight insurgencies, the COIN side. I would argue...us definitional precision which in turn aids with research and comprehension. Political science and political theory offer major contributions to COIN...nder/ OP Deser t Light ning II PE (12-24 Dec) B-10* Analy st Note book/ ARC GIS/ OP Dese rt Light ning II PE B-9

  14. China Report, Political, Sociological and Military Affairs, No. 428

    DTIC Science & Technology

    2007-11-02

    concerned. From the very beginning, comrades like Bai Qing- qiang and others had an incorrect view and feeling toward the letter written to NANFANG...mass line. Comrade Ren Zhongyi expressed the hope that everybody would express his views fully and speak his mind freely. Secretary Wang Ning [3769...Zhong- yi, Li Jianzhen [2621 1017 4176], Xie Fei [6200 7236], Wu Nansheng [0702 0589 3932], Wang Ning, Yin Linping [2651 1627 1755], Kou Qingyan [1379

  15. Safety Pedal for Foot-Operated Machinery

    NASA Technical Reports Server (NTRS)

    Garcia, G. D.

    1985-01-01

    Ninged structure prevents inadvertent use. Forward motion of foot on yoke plate necessary to operate brake pedal. Downward force on yoke plate turns locking/releasing laver, which then pushes locking pin into indexing hole. New pedal improves both productivity and safety of power brakes and such other machines as metal shearers and punch presses.

  16. HEALTH EFFECTS OF CHRONIC EXPOSURE TO ARSENIC VIA DRINKING WATER IN INNER MONGOLIA: IV. DISTRIBUTION OF ARSENIC CONCENTRATIONS IN WELLS

    EPA Science Inventory

    HEALTH EFFECTS OF CHRONIC EXPOSURE TO ARSENIC VIA DRINKING WATER IN INNER MONGOLIA:
    IV. DISTRIBUTION OF ARSENIC CONCENTRATIONS IN WELLS

    Zhixiong Ning, B.S., Zhiyi Liu,B.S., Shiying Zhang, B.S., Chenglong Ma, B.S., Inner Mongolia Ba Men Anti-epidemic Station, Michael Ri...

  17. Large Grain Niobium Cavity R&D in Asia and the Future

    SciTech Connect

    Saito, K; Furuta, F; Saeki, T; Inoue, H; Shim, J; Ahn, J; Kim, E S; Xu, Q; Zong, Z; Gao, J; Kneisel, P; Myneni, G R

    2007-09-01

    The status of the large grain niobium cavity R&D in Asia and the future scope are presented. Recently KEK has received CBMM and NingXia large grain niobium sheets through collaborations. KEK has fabricated 1.3 GHz single cell cavities using these materials and measured the cavity performance. Those results are presented in this paper.

  18. Large Grain Niobium Cavity R and D In Asia and the Future

    SciTech Connect

    Saito, K.; Furuta, F.; Saeki, T.; Inoue, H.; Shim, J.; Ahn, J.; Kim, E. S.; Xu, Q.; Zong, Z.; Gao, J.; Kneisel, P.; Myneni, G. R.

    2007-08-09

    The status of the large grain niobium cavity R and D in Asia and the future scope are presented. Recently KEK has received CBMM and NingXia large grain niobium sheets through collaborations. KEK has fabricated 1.3 GHz single cell cavities using these materials and measured the cavity performance. Those results are presented in this paper.

  19. Large Grain Niobium Cavity R&D In Asia and the Future

    NASA Astrophysics Data System (ADS)

    Saito, K.; Furuta, F.; Saeki, T.; Inoue, H.; Shim, J.; Ahn, J.; Kim, E. S.; Xu, Q.; Zong, Z.; Gao, J.; Kneisel, P.; Myneni, G. R.

    2007-08-01

    The status of the large grain niobium cavity R&D in Asia and the future scope are presented. Recently KEK has received CBMM and NingXia large grain niobium sheets through collaborations. KEK has fabricated 1.3 GHz single cell cavities using these materials and measured the cavity performance. Those results are presented in this paper.

  20. Cooperative Control of Distributed Autonomous Vehicles in Adversarial Environments

    DTIC Science & Technology

    2006-08-14

    Transactions on Robotics , 2005. • G. Chasparis and J. Shamma, “Linear-Programming-Based Multi-Vehicle Path Plan- ning with Adversaries”, Proceedings of...Drill”, Proceedings of the American Control Conference, 2002. • M. Earl and R. DAndrea, “Iterative MILP methods for vehicle control problems”, IEEE

  1. Military Planning Systems and Stability Operations

    DTIC Science & Technology

    2010-06-01

    wicked problems, a term coined in 1973 by Horst Rittel and Melvin Webber in an article on general plan- ning theory. At that time, Rittel and...Review 89 (March–April 2009), 107. 48 Michael, 439–442. 49 Wass de Czege, 8. 50 Horst W.J. Rittel and Melvin M. Webber, “Dilemmas in the General Theory of

  2. Wiki Literature Circles: Creating Digital Learning Communities

    ERIC Educational Resources Information Center

    Edmondson, Elizabeth

    2012-01-01

    Teenagers love being social, and Web 2.0 technologies have provided students with new avenues to mingle. Although many teachers may view Web 2.0 technologies (Facebook, MySpace, Twitter, blogs, wikis, Nings) as a distraction from homework and a potential danger zone in the classroom, it would be negligent for them to ignore the ramifications of…

  3. Qualitative Process Theory.

    DTIC Science & Technology

    1984-07-01

    write a heat flow process that violates energy conservation and transfers " caloric fluid" between the source and destination. The assumptions made about...removed in ease of ex1-0ClCits. Seco nd, if’ thle program is drawNing concilsions that rely criticaillyoi atClrsum in, then1 it IIos’t test ss

  4. Using a Social Networking Site for Experiential Learning: Appropriating, Lurking, Modeling and Community Building

    ERIC Educational Resources Information Center

    Arnold, Nike; Paulus, Trena

    2010-01-01

    With social networking sites playing an increasingly important role in today's society, educators are exploring how they can be used as a teaching and learning tool. This article reports the findings of a qualitative case study about the integration of "Ning" into a blended course. The study draws on the perspectives of the students, the…

  5. Registration of near-isogenic winter wheat germplasm contrasting in Fhb1 for fusarium head blight resistance

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Chinese wheat Ning7840 (Triticum aestivum L.) contains Fhb1, a major quantitative trait locus (QTL) for Fusarium head blight (FHB) resistance, and has been widely used as a resistant parent in breeding programs worldwide, but due to its poor adaptation in the US, its progenies usually exhibit re...

  6. Edmodo: A Great Tool for School Librarians

    ERIC Educational Resources Information Center

    Holzweiss, Kristina

    2013-01-01

    School librarians are in a profession where it is easy to be isolated. Often, school districts have only one certified librarian and school librarians must create ways to connect with one another and with other educators. Social media opportunities such as Facebook, LinkedIn, blogs, wikis, and nings are powerful ways of staying connected on a…

  7. Joint Tactical Information Distribution System (JTIDS). Class 3 Terminal Conceptual Study. Volume 4. Appendix A. Mission Profile Detail. Appendix B. Moments of the Decision Variable for preamble Detection

    DTIC Science & Technology

    1978-07-07

    deriv apa ity . typi al nn t- ivity , r n , mes~ a e tyre s . r elay nd ssibl nrtiti ning r r multi le n t requirement s . A ompa r son f the onfi...level, the REDEYE section leader is norma -1!/ appointed as the battalion air defense officer. U. In the maneuver battalions REDEYE sections, 2 teams

  8. Self-Regulation during E-Learning: Using Behavioural Evidence from Navigation Log Files

    ERIC Educational Resources Information Center

    Jeske, D.; Backhaus, J.; Stamov Roßnagel, C.

    2014-01-01

    The current paper examined the relationship between perceived characteristics of the learning environment in an e-module in relation to test performance among a group of e-learners. Using structural equation modelling, the relationship between these variables is further explored in terms of the proposed double mediation as outlined by Ning and…

  9. Social Networking Goes to School

    ERIC Educational Resources Information Center

    Davis, Michelle R.

    2010-01-01

    Just a few years ago, social networking meant little more to educators than the headache of determining whether to penalize students for inappropriate activities captured on Facebook or MySpace. Now, teachers and students have an array of social-networking sites and tools--from Ning to VoiceThread and Second Life--to draw on for such serious uses…

  10. The Cold Gas-Dynamic Spray and Characterization of Microcrystalline Austenitic Stainless Steel

    DTIC Science & Technology

    2014-09-01

    use of thermal spray techniques, such as plasma spray, flame spray, or high velocity oxygen fuel (HVOF) spray, to build the material back up...its deposition and that softer particles may deposit better than harder ones. Ning et al. also found that an annealing pretreatment of their C-Cu

  11. Flexible Manufacturing System Handbook. Volume 3. Buyers/User’s Guide

    DTIC Science & Technology

    1983-02-01

    95 6.3.2 Movement of Workpieces and Material Handling System . ... 96 6.3.3 Tool Management ...include site planning, production planning, process plan- ning, part programming, quality control, tool management and maintenance. An adequate...requirements. Required are a system manager , 0.25 electrical technician, and 0.25 mechanical technician for every four machines in the system. Depending

  12. European Science Notes Information Bulletin.

    DTIC Science & Technology

    1992-12-01

    Robot Systems - formerly Prof. Gerard ning an IMS (intelligent manufacturing system) Duelen, now retired but not yet replaced proposal. On the wall...Manufacturing - 283 * Design Research and an Industrial Application of Systematic Design Methodologies - 293 - * Manufacturing and Robotics Research at the...Design Methodologies .................................................. 293 D. E. Whitney Manufacturing and Robotics Research at the Katholieke

  13. Management Aspects of Software Maintenance.

    DTIC Science & Technology

    1984-09-01

    TRADITIONAl METHODS ..... ............. 50 C. PARAMETRIC MODELS ..... .............. 53 D. ESTIMATING MAINTENANCE COSTS ... ......... 57 1. Planning...maintenance. 10 10A 4 7he extensive research dcne cn software development and on the management of the development process is only ncw begin- ning to...and external factors. C. GENEEAL PROCEDURE The procedure used was to research literature concerning software maintenance. Particular emphasis was

  14. Analysis of the Hessian for Inverse Scattering Problems. Part 1: Inverse Shape Scattering of Acoustic Waves

    DTIC Science & Technology

    2011-06-01

    sufficient optimality conditions for shape functionals. Control and Cybernetics, 29:485–512, 2000. [14] Philippe Blanchard and Erwin Brüning...Mathematical Methods in Physics. Birhäuser Verlag, 2003. [15] Ken Kreutz-Delgado. The complex gradient operator and the CR-calculus. Technical Report UCSD

  15. Analysis of the Hessian for Inverse Scattering Problems. Part 3. Inverse Medium Scattering of Electromagnetic Waves in Three Dimensions

    DTIC Science & Technology

    2012-08-01

    mathematics. [3] Philippe Blanchard and Erwin Brüning, Mathematical Methods in Physics, Birhäuser Ver- lag, 2003. [4] Tan Bui-Thanh, Carsten Burstedde, Omar...Order, Springer-Verlag, Berlin, second (Classics in Mathematics) ed., 2001. [16] Ken Kreutz-Delgado, The complex gradient operator and the CR-calculus

  16. RESIDENTIAL EXPOSURE TO DRINKING WATER ARSENIC IN INNER MONGOLIA, CHINA

    EPA Science Inventory

    Residential exposure to drinking water arsenic in Inner Mongolia, China
    Zhixiong Ning1, Richard K. Kwok2, Zhiyi Liu1, Shiying Zhang1, Chenglong Ma1, Danelle T. Lobdell2, Michael Riediker3 and Judy L. Mumford2
    1) Institute of Endemic Disease for Prevention and Treatment in I...

  17. ESTIMATING RESIDENTIAL EXPOSURE TO DRINKING WATER ARSENIC IN INNER MONGOLIA, CHINA FOR EPIDEMIOLOGIC STUDIES

    EPA Science Inventory

    ESTIMATING RESIDENTIAL EXPOSURE TO DRINKING WATER ARSENIC IN INNER MONGOLIA, CHINA FOR EPIDEMIOLOGIC STUDIES

    Richard Kwok1, Pauline Mendola1 Zhixiong Ning2, Zhiyi Liu2 and Judy Mumford1

    1) Epidemiology and Biomarkers Branch, Human Studies Division, NHEERL, US EPA, R...

  18. Using Blogs to Promote Literary Response during Professional Development

    ERIC Educational Resources Information Center

    Colwell, Jamie; Hutchison, Amy; Reinking, David

    2012-01-01

    This article describes a project that studied 15 preservice teachers' perceptions of and reactions to responding to children's and young adult literature using a Ning blog. These perceptions and reactions provided insight into various practical aspects of using a social networking blog to facilitate literature response in a teacher education…

  19. Flying Operations

    DTIC Science & Technology

    2007-11-02

    route obstacles, terrain features, plan- ning and chum responsibilities, route abort procedures, techniques and considerations. 3.4.8.8.8. Special...Composite Force Training CHUM —Chart Update Manual CIRVIS—Communication Instructions Reporting Vital Intelligence Sighting CM—Countermeasures CMR—Combat

  20. Hoyt S. Vandenberg, The Life of a General

    DTIC Science & Technology

    2000-01-01

    the war he was selected by a women’s magazine as "Mr. America" in 1948 Vandenberg crowned the Shenandoah Apple Blossom Festival Queen; he presented the...a cherry pie in the eve- nings, which he was occasionally known to share with his family. He enjoyed argu- ing with his children at the dinner table

  1. The Impact of Alternative International Economic Policies on U.S. Defense Interests Abroad

    DTIC Science & Technology

    1974-12-30

    begin- nings of analytic model development of the type required for the project are found only in particular case studies. ■^ ■^gf^iM^^|«Mg|^ugj^ mail ... art |l, lttm g.-,.,. ,. H inaniih mi ■ ,i o Implications of Findings. Although the literature survey was not as help- ful as was expected

  2. Patterns of HIV Prevalence and HIV Risk Behaviors among Injection Drug Users Prior to and 24 Months following Implementation of Cross-Border HIV Prevention Interventions in Northern Vietnam and Southern China

    ERIC Educational Resources Information Center

    Hammett, Theodore M.; Kling, Ryan; Johnston, Patrick; Liu, Wei; Ngu, Doan; Friedmann, Patricia; Binh, Kieu Thanh; Dong, Ha Viet; Van, Ly Kieu; Donghua, Meng; Chen, Yi; Des Jarlais, Don C.

    2006-01-01

    In 2002, we implemented a 4-year HIV prevention intervention for injection drug users (IDUs) in Lang Son Province, Vietnam, and Ning Ming County, Guangxi Province, China, a cross-border region seriously affected by inter-twined epidemics of heroin injection and HIV infection. The interventions involve peer education on HIV risk reduction and…

  3. Simulation Study of Evacuation Control Center Operations Analysis

    DTIC Science & Technology

    2011-06-01

    host country nationals from life threatening situations in foreign countries. Plan - ning for these operations is difficult due to its dynamic nature and...complex inter- department command and execution structure. Planning efficiencies could be realized through insights into dependencies and fundamental...9 3.2 Setting of objectives and overall project plan . . . . . . . 9 3.3 Model conceptualization . . . . . . . . . . . . . . . . . . 10

  4. PREGNANCY AND PERINATAL OUTCOMES IN RELATION TO DRINKING WATER ARSENIC EXPOSURE IN BAMEN, INNER MONGOLIA, CHINA

    EPA Science Inventory

    Pregnancy and Perinatal Outcomes in Relation to Drinking Water Arsenic Exposure in BaMen, Inner Mongolia, China
    Danelle T. Lobdell, Zhixiong Ning, Richard K. Kwok, Judy Mumford, Zhi Yi Liu, Pauline Mendola

    Introduction: Close to 40 million people worldwide are exposed t...

  5. DRINKING WATER ARSENIC AND PERINATAL OUTCOMES

    EPA Science Inventory

    Drinking Water Arsenic and Perinatal Outcomes
    DT Lobdell, Z Ning, RK Kwok, JL Mumford, ZY Liu, P Mendola

    Many studies have documented an association between drinking water arsenic (DWA) and cancer, vascular diseases, and dermatological outcomes, but few have investigate...

  6. Using Social Networking for Online Role-Plays to Develop Students' Argumentative Strategies

    ERIC Educational Resources Information Center

    Beach, Richard; Doerr-Stevens, Candance

    2011-01-01

    Social networking sites may include argumentative writing about particular issues in which participants adopt competing perspective and discourses on those issues. This study examined roles and discourses adopted by high school students participating in an online role-play conducted on a Ning platform regarding their school's Internet policies on…

  7. Design of a Learning Environment for Management Education

    NASA Astrophysics Data System (ADS)

    Cinque, Maria; Martini, Antonella

    There has been a vast debate in recent years about usage patterns of social computing and web 2.0 tools in learning contexts. A growing number of researchers suggest that certain pedagogical approaches are best suited in these contexts, since they involve active engagement, social learning, continuous feedback, enabling students' autonomous understanding and the transfer of those skills to useful or real-life settings. In this article we present the use of a social network as part of a formal course of Management at the University of Pisa. The institutional VLE - based on Moodle - has been integrated with a student support group hosted on Ning. Problems and opportunities for using Ning have been discussed in small groups and students feedback will be reported. The shift from Learning Management System (course centric) to a Personal Learning Environment (people centric) and then to Personal Learning Network is also been discussed and a framework for Education 2.0 is provided.

  8. Synthesis and Characterization of BaFeO3, (Ba,Bi)FeO3, and Related Epitaxial Thin Films and Nanostructures

    DTIC Science & Technology

    2009-01-01

    and M . Maglione , Journal of Applied Physics 103, 024105 (2008). 69 D. H. Wang, W. C. Goh, M . Ning, and C. K. Ong, Applied Physics Letters 88, 212907...µoH and the magnetization M , and at very high magnetic fields (depending on the material) the magnetization M saturates, called the saturation...causes the magnetization M to eventually reach zero, reaching the coercive field Hc at M = 0.8 Antiferromagnets consist of two interpenetrating

  9. Naval S&T Strategy: Innovations For The Future Force

    DTIC Science & Technology

    2015-01-01

    hazards afloat and ashore • Biometric identification and surveillance • Tactical site exploitation and forensics • Signatures management across the...the ability to defend platforms against attack span- ning the range from small arms and hand- held weapons, swimmers and small boats to ballistic ...Defeat • Counter RPGs and ATGMs • Counter Tactical Surveillance and Targeting • Biometrics • Forensics • Personal Survivability • Vehicle and

  10. European Scientific Notes. Volume 35, Number 12,

    DTIC Science & Technology

    1981-12-31

    facilities worldwide, Serological identification of are inexpensive, easily transported, and Campylobacetera is complicated by the do not have to be sterile...were presented to distinguish it from ulcerative colitis, in poster sessions followed by discussion proctitis , and inflammatory bowel disease, sessions...workers in Switzerland, ning radiation at 300 Miz. The system who used less modern equipment. The wa designed to provide points at a rate combined

  11. Asbestos: Securing Untrusted Software with Interposition

    DTIC Science & Technology

    2005-09-01

    consistent intelligible interfaces to different types of resource. Message-based operating systems, such as Accent, Amoeba , Chorus, L4, Spring...based interfaces. However, none of these systems can provide the combined security and flexibility of Asbestos. For example, Amoeba bases access...systems such as L4, Amoeba , V, Chorus and Spring can isolate system services by run- ning them as independent, user-level processes and pro- vide

  12. Wu Chien-Shiung: A brief biography

    NASA Astrophysics Data System (ADS)

    Chiang, Tsai-Chien

    2015-12-01

    My first encounter with professor Wu Chien-Shiung, a leading experimental physicist, 31 years ago inspired me to write her biography. I received much encouragement when planning this biography, especially from Dr. Yang Chen Ning, whose biography I wrote later. The real challenges in writing Wu's biography were finding the balance between both sides of her life and overcoming the obstacle that, unlike theoretical physicists (such as Yang), experimental physicists are inclined more to deeds than to words.

  13. Improvement of Operations and Maintenance Techniques Research Program: Inventory of Training Structures in Estuaries

    DTIC Science & Technology

    1988-08-01

    14a.2) Yaquina River near Submerged dikes Miles II and 13.5 Lateral dikes Toledo, Oreg. (14b) (2) Umpqua River , Training jetty Mouth (14c...10 ft deep. The mean range of tide is about 8 ft. (NOAA Nautical Chart No. 18581) Umpqua River , Oregon 114. Site 14c, training jetty (longitudinal dike... RIVER -I Figure 97. Submerged dikes in the Yaquina River UMPQUA RIVER NORTH JETTY " WINCHESTER -. -, 0 M, BAY SOUTH JETTY TR NING I ___ JETTY

  14. Parallel Worlds: Agile and Waterfall Differences and Similarities

    DTIC Science & Technology

    2013-10-01

    Parameters Planning Poker Lightweight Process Product Owner Milestone A/Milestone B/Milestone C Refactoring Oversight Release Peer Review...feedback, courage, and respect. XP consists of the following core practic- es; planning poker , on-site customer, small releases, metaphor, simple design...consists of the following core practices; plan- ning poker , on-site customer, small releases, meta- phor, simple design, test-driven development, re

  15. Optoelectronics: Continuously Spatial-Wavelength-Tunable Nanowire Lasers on a Single Chip

    DTIC Science & Technology

    2014-01-28

    multiple-bandgap solar cells using spatially composition-graded CdxPb1-xS nanowires on a single substrate: a design study, Optics Express (07 2011...R.B. Liu. SPATIALLY COMPOSITION-GRADED ALLOY SEMICONDUCTOR NANOWIRES AND WAVELENGTH SPECIFIC LATERAL-MULTIJUNCTION FULL-SPECTRUM SOLAR CELLS , (06...Stat. Sol B247, 774-788 (2010) 6. D. A. Caselli and C.Z. Ning, High-performance laterally-arranged multiple-bandgap solar cells using spatially

  16. Korean Affairs Report.

    DTIC Science & Technology

    2007-11-02

    of Seoul University gathered at the campus square and held a memorial service for the victims of the Kwangju incident and Kim Tae- hun , a student who...attack target to suppress with bayonets the struggle by using arms, indiscriminately firing rifles and guns at Kwangju citizens who turned out to a...suit, Kim Ki-sok from Hadong- gun , Kyongsang-namdo, maintained that it is an-act.run- ning against "political ethics" for the former DKP assemblymen

  17. Preparing the Pipeline: The U.S. Cyber Workforce for the Future

    DTIC Science & Technology

    2012-08-01

    lives: newspapers are online, automobiles contain computerized systems , critical infrastructures such as water, electricity, and communications are...University System of Maryland (USM) Cyber Security Task Force lists “expanding the pipeline for cy- ber careers” as an actionable recommendation in its...to keep them run- ning and secure. Unmanned aerial systems (UAS) are emblematic of this trend. A UAS is essentially a flying platform composed of

  18. Preparing the Pipeline: The U.S. Cyber Workforce for the Future (Defense Horizons, Number 72)

    DTIC Science & Technology

    2012-08-01

    lives: newspapers are online, automobiles contain computerized systems , critical infrastructures such as water, electricity, and communications are...University System of Maryland (USM) Cyber Security Task Force lists “expanding the pipeline for cy- ber careers” as an actionable recommendation in its...to keep them run- ning and secure. Unmanned aerial systems (UAS) are emblematic of this trend. A UAS is essentially a flying platform composed of

  19. Advanced Multi-Moment Microphysics for Precipitation and Tropical Cyclone Forecast Improvement within COAMPS

    DTIC Science & Technology

    2013-09-30

    Hurricane Earl (2010) Rapid-scan satellite-derived winds, inner core airborne Doppler radar radial wind (Vr) and dropsonde observations are assimilated...airborne Doppler radar ra- dial wind and dropsonde observations using EnKF for Hurricane Earl (2010), the Goddard Lin micro- physics and MYJ PBL schemes were...with MSLP except for an immediate spin - ning-down in the first 3 hours. In summary, the assimilation of satellite-derived winds improves the track

  20. Deposition of (Y(2)BaCuO(5)/YBa(2)Cu(3)O(7-x)) x N Multilayer Films on Ni-Based Textured Substrates

    DTIC Science & Technology

    2005-01-01

    failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE...substrates was investigated, as a new candidate coated conductor architecture for improved flux pinning. Significant enhancements of critical current ...new candidate coated conductor architecture for improved flux pin- ning. Significant enhancements of critical current density (Jc) > 6-fold were

  1. Annual Report of the Secretary of Defense on Reserve Forces for Fiscal Year 1975

    DTIC Science & Technology

    1976-06-08

    mission. Accompanicd by new Soldiers Manuals for different military occupational specialties (MOS) which accomplish the same function for individual...The tra ning of three A-7A squadrons in accordance with the "Train- Ing and Readiness Manual for Carrier Attack Air Wings" has pro- vided the squadrons...maintenance and operations manual for engine test systems, V.5. I APPENDIX GLOSSARY OF NAVAL RESERVE TERMS AND ABBREVIATIONS 1I. COMMANDERS and COMMANDS

  2. Efficient BDD-Based Planning for Non-Deterministic, Fault-Tolerant, and Adversarial Domains

    DTIC Science & Technology

    2003-06-01

    operator ( ). If the power is on (that is, AS> is = >@.A ), they increase or decrease the position, otherwise they cause no position change...tolerant planning and adversarial planning. Fault tolerant plan- ning addresses domains where non-determinism is caused by rare errors. The current...for synthesizing fault tolerant plans. Adversarial planning considers situations where non-determinism is caused by uncontrollable, but known

  3. Extracting Functionally Equivalent Object-Oriented Designs from Legacy Imperative Code

    DTIC Science & Technology

    1997-09-01

    rocket diversions. Sure hope the Big Kahuna fits in my van. Thanks, Cookie, for the trip to Salt Lake City. Squatters was great, but I could have done...open field in cognitive science . However, the ideas presented here are an adequate presentation of the current literature in this field. 1.3 Related...Jersey: Prentice Hall, 1996. 25. Gries, David. The Science of Programming. Springer-Verlag, 1981. 26. Harandi, Mehdi T. and Jim Q. Ning. "Knowledge-Based

  4. The United States Remains Unprepared for Oil Import Disruptions. Volume II. Detailed Review of Current Emergency Programs and Alternative Approaches.

    DTIC Science & Technology

    1981-09-29

    and Development OECP Office of Energy Contingency Planning OMB Office of Management and Budget OPEC Organization of Petroleum Exporting Countries PEMEX ...Petroleos Mejicanos ( PEMEX ), Mexico’s State oil company, to acquire up to 110 MMB of oil for the SPR. DOE officials estimate that, depending on...by mutual agreement. IF DOE and PEMEX fail to agree on prices within 10 days after the begin- ning of each quarter, PEMEX may suspend deliveries for

  5. Military Intelligence Professional Bulletin (MIPB). Volume 37, Number 2, April-June 2011

    DTIC Science & Technology

    2011-04-01

    PEMEX ), Mexico’s state-owned petroleum indus- try, which is the third largest producer of crude oil in the world.5 While limited to siphoning oil...from pipelines in 2009, Los Zetas began kidnapping PEMEX employees in May 2010.6 Mysterious explo- sions have frequently occurred at pumping and re...fi ning stations throughout Zeta-controlled eastern Mexico. The explanations for these disasters have been ambiguous at best. PEMEX production, along

  6. The Enlisted Steady State-Simulation (ESS-SIM) Tool

    DTIC Science & Technology

    2014-07-01

    The Enlisted Steady State-Simulation ( ESS -SIM) Tool David M. Rodney • Peggy A. Golfin • Molly F. McIntosh DIM-2014-U-007587-Final July 2014 This...situation. We built and made use of a simulation model, ESS -Sim (Enlisted Steady- State Simulation), to obtain insights into attainable levels of...fleet manning and estimate the impact of policy changes on fleet man- ning. This information memorandum describes this model. Model overview We built ESS

  7. United States Air Force F-35A Operational Basing Environmental Impact Statement. Appendix E: Comments

    DTIC Science & Technology

    2013-09-01

    neighborhoods which are already being ruined by the F-15s. NO to the noise polution . No to the air polution . No to ruining the environment and ruining...No to the air polut ion . No to ruining the environment and rui ning people’s lives. Thank you for listening to the citizens. Ruth Drake 1...Headquarters Air Combat Command Installations and Mission Support Directorate, Engineering Division (A7N) 129 Andrews Street Langley Air Force Base, VA

  8. The Dawning of a New Day for the Southwest: A History of the Tulsa District Corps of Engineers 1939-1971

    DTIC Science & Technology

    1975-01-01

    River Dam Authority ( GRDA ) as it relates to the Corps, and the investigating and plan- ning for future construction. Following it a chapter will...builder was the GRDA which had been authorized by the Oklahoma ~gislature on 26 April 1935 to develop hydroelectnc power on the Grand River. 8 Men...appropriations from which a grant could be made to an agency of the GRDA type. In 1937 the Oklahoma Legislature repealed a provision enacted in

  9. Why the Greenwich Meridian Moved

    DTIC Science & Technology

    2015-08-01

    Intelligence Agency, 7500 GEOINT Dr., Springfield, VA 22150, USA 2 Analytical Graphics, Inc., 220 Valley Creek Blvd, Exton, PA 19341-2380, USA 3 Astronomy ...the astronomi - cal zenith, Za, is north of the geodetic zenith, Zg; and η is positive when Za is east of Zg (Torge 2001, p. 219). These slopes can be...frame and in astronomical computations for positional astronomy were introduced in 1984 after 10years of plan- ning (Kaplan 1981 and references

  10. A Numerical Model of Laser Induced Fluorescence in a Hydrogen Plasma

    DTIC Science & Technology

    1990-09-11

    then be used to calcu- late the rate (1/sec) for such a process in a plasma with a given electron speed distribution , f(v). For example, for electron...temperature used to calculate the vibrational distribution of H2 may actually be the electron temperature and not the gas temperature. Finally, since the... distributions . Thus, the expression given by Zel’dovich and Raizer (1966), described at the begin- ning of this section, may be used to estimate

  11. Generation of Clutter within a Structured Target Synthesizer

    DTIC Science & Technology

    2012-09-01

    recognize false target generated by digital- image-synthesiser,” in Proceedings of the 2008 International Symposium on Information Science and...Jun Tang and Ying-ning Peng, “Research on deception jamming for countering ISAR,” in Proceedings of the 2009 IET International Radar Conference...Yuan Li, Xue-mei Luo and Ga-huan Lv, “The study of multi-false targets synthesizing technology against chirp ISAR,” in Proceedings of International

  12. Proceedings of the International Symposium on Optimum Structural Design,

    DTIC Science & Technology

    1981-01-01

    terminology and linear-quadratic problem are given in Section 4 along new concepts, the designer was rewarded with new solu- with the specific...Leagendre polynomials. Per- in ; we obtain the relations for determi- forming the standart calculation we obtain ning the zeroth, first, second ... order...Prager’s terminology [4, 5], the generalised state of the art report on analytical solutions for stresses Q, strains %, displacements u and loads p

  13. A Novel Desulfurizer-Catalyst Combination for Logistic Fuel Reforming

    DTIC Science & Technology

    2009-04-27

    cells ( SOFCs ) for NASA and the Army. NASA envisions employing fuel cells run- ning on clean reformate from jet fuels in their future unmanned aerial...please contact the AMMTIAC Editor. http://wstiac.alionscience.com/quarterly http://wstiac.alionscience.com/quarterly Report Documentation Page Form...ApprovedOMB No. 0704-0188 Public reporting burden for the collection of information is estimated to average 1 hour per response, including the time for

  14. Medical Surveillance Monthly Report (MSMR). Volume 15, Number 10, December 2008

    DTIC Science & Technology

    2008-12-01

    diagnosis code (in any position) that specifi ed a current head and/or brain injury or postconcussion syndrome. Hospitalizations with “history of...traumatic brain injury” (ICD-9-CM V15.5 plus relevant extender) as the only TBI indicator diagnosis code were not considered primary case-defi ning...events. Th e secondary defi nition of a TBI event was an ambulatory visit with a TBI indicator diagnosis code (in any position) that specifi ed a

  15. Short of War: Major USAF Contingency Operations, 1947-1997

    DTIC Science & Technology

    2000-01-01

    for Middle East operations . The Air Force’s involvement was divided into three distinct actions : Composite Air Strike Force " Bravo " deployed into...Force Alpha arrived in Lebanon on July 19 . While Task Force Bravo remained on twenty-four-hour alert in Germany, Task Force Charlie- made up primarily...deployment phase of CASF Bravo included inadequate plan- ning, experience, and supplies. Most significant, however, was unsatisfactory air-to-air

  16. Archaeological Reconnaissance of the Oliver Lock and Dam Project Area, Tuscaloosa County, Alabama. Phase I.

    DTIC Science & Technology

    1982-09-16

    Fort Strother on the Coosa, remaining five months and preparing for the final engagement, to be fought on March 25, 1814 , at Horseshoe Bend . Now it will...of 1814 , only~ six months after the For. Mims mass- acre, most of the battles hdbeen fought, and General Jackson was plan- ning a final serie- of... 1814 ) period. A model of the Holocene terrace geomorphology was developed to dis- cuss settlement patterns. A strategy for deep testing to locate

  17. Méningo-vascularite bactérienne révélant un adénome hypophysaire

    PubMed Central

    Bouchal, Siham; Razzouki, Hanane; Elkhyat, Salma Ibn; Maaroufi, Mustafa; El Ouali, Ouarda; Messouak, Ouafae; Belahsen, Mohammed Faouzi

    2015-01-01

    Un macroadénome à prolactine se présente généralement par un syndrome hormonal associé à un syndrome tumoral. Une méningite bactérienne compliquant un macroprolactinome en dehors de toute thérapie médicale ou chirurgicale est rarement rapporté dans la littérature. Mme R.C âgée de 48 ans s'est présentée aux urgences pour trouble de conscience fébrile. La ponction lombaire a révélé une méningite bactérienne. L'imagerie cérébrale a mis en évidence un aspect de vascularite cérébrale et un processus de la loge sellaire avec lyse du plancher faisant évoquer une brèche ostéoméningée. Le bilan biologique a montré une hyperprolactinémie à 200 mg/dl. La patiente est mise sous antibiothérapie à dose méningée et une corticothérapie associée à un traitement par la Cabergoline. Le traitement chirurgical de la brèche ostéoméningée s'est fait par voie endonasale. L’évolution est marquée par une nette amélioration clinique et biologique et l'absence de récidive de la méningite après un recul de 14 mois. Un macroprolactinome peut provoquer une brèche ostéoméningée en dehors de tout traitement médical ou chirurgical et avoir comme première manifestation une méningite infectieuse. PMID:25995804

  18. Software Reengineering of Department of Defense Information Systems Using Object-Oriented Technology.

    DTIC Science & Technology

    1995-07-01

    10 2.3.2 IDEFIX M odels .................................................................................... 14 2.4 PROCESS...Improvement 00 Analysis Models IDEFiX - o- 00 Analysis Process-Based ow.00 Analysis * 7.System Models (e.g., Structured . Analysis)........00 Design - o...BRU92] T. A. Bruce, Designing Quality Databases with IDEFIX Information Models, Dor- set House Publishers, New York, 1992. 0 [NIN94] J. Ning, A

  19. JPRS Report, Science & Technology, China

    DTIC Science & Technology

    1992-10-09

    Romania [Xie Ning; KEJIRIBAO, 28 Aug 92] 21 Foundation Laid for Major Floppy Disk Production Plant [Ru Yi; JISUANJISHIJIE, 26 Aug 92] 21...JISHU, Jul 92] 28 Changde Digital SPC PBX Production Line Passes Acceptance Check [Yang Yusong; ZHONGGUO DIANZI BAO, 10 Aug 92] 28 First...of profit for developing new products and allowing them to add this portion into their production cost and exempt from their income taxes. The

  20. Genocide and Airpower

    DTIC Science & Technology

    2008-01-01

    strategy, history, international politics, and culture. He is the author of The Three German Navies: Dissolution, Transition, and New Begin­ nings and...Military History, War in History, War and Society, and the German Studies Review. His current research interests include the challenges posed by...charged and prosecuted German organizations and individuals with planning, initiat­ ing, and waging wars of aggression; conspiring to commit crimes

  1. Confluence Analysis for Distributed Programs: A Model-Theoretic Approach

    DTIC Science & Technology

    2011-12-18

    Dedalus language, we will refer to two run- ning examples for the remainder of the paper. Example 7. A simple asynchronous marriage ceremony...distributed commit protocols and marriage ceremonies [22]. For simplicity (and felicity), Example 7 presents a simple asynchronous voting program with a...fixed set of members: a bride and a groom. The marriage is off (runaway() is true) if one party says “I do” and the other does not. However, the Dedalus

  2. C. N. Yang Discusses Physics in People's Republic of China

    NASA Astrophysics Data System (ADS)

    Yang, Chen Ning

    2013-05-01

    Before the cultural revolution started in 1966, high-energy theorists in the People's Republic of China were very active, according to Chen Ning Yang, who recently returned from a month-long visit there. He learned that in 1965 or 1966 Chinese theorists had developed a theory of "stration" (for strata) that very much parallels the quark theory, which was proposed by Murray Gell-Mann and by George Zweig in 1964...

  3. Molecular Beam Epitaxial Materials Study for Microwave and Millimeter Wave Devices.

    DTIC Science & Technology

    1978-10-01

    Laue of GaAs Substrate 40 16. Diagrams of Component and Diffraction Geometry 41 for Reflection Berg -Barrett X-Ray Diffraction Topography 17. Scanning...varied. The results of back-reflection Laue analyses, Berg -Barrett analyses, Laue Reflection Topography and Scan- ning Reflection Topography are...parasitic scattering also showed up and proved to be a problem in Berg -Barrett studies. The Berg -Barrett (BB) technique illustrated in Figure 16 was

  4. Breast Tumor Specific Peptides: Development of Breast Carcinoma Diagnostic and Therapeutic Agents

    DTIC Science & Technology

    2000-11-01

    Postdoctoral Fellow Mr. Ravi Komatireddy, Undergraduate Biochemistry Major Ms. Lara McKee, Undergraduate Biochemistry Major Ms. Donna Whitner, Senior...Libraries Natalia G. Karasseva, Vladislav V. Glinsky, Ning X. Chen, Ravichandra Komatireddy, and Thomas P. Quinn*. Department of Biochemistry , University of...libraries have yielded putative disulfide constrained sequences ( Devlin et al., 1990, Kay et al., 1993). Most of the reported disulfide-containing 10

  5. The Super-Secret, Never-before-Revealed Guide to Web 2.0 in the Classroom

    ERIC Educational Resources Information Center

    Schaffhauser, Dian

    2010-01-01

    In spite of the fact that web 2.0-enabled tools and services are supposed to be easy to set up and simple to use, some faculty in higher education never got that memo. They don't know a tweet from a tag, identify Ning as a four-letter word for "river in China", and would probably guess that Squidoo is a friend of SpongeBob and Patrick. This guide…

  6. An Investigation of Synthetic Aperture Radar Autofocus,

    DTIC Science & Technology

    1985-04-01

    Authors: I P Finley and J W Wood Date: April 1985 SUMMARY SAR imagery is generated by matched filtering the raw azimuth signal history, assuming...ning from the raw data the appropriate matched filter. In this memorankm the principles of SAR and the requirement for an auto- focus system are...discussed. Three autofocus methods are investigated: measure- ment of the power spectrum, contrast maximisation, and registration of multilook images. The

  7. Distributed Heterogeneous Simulation of a Hybrid-Electric Vehicle

    DTIC Science & Technology

    2006-03-29

    operate as a generator to convert mechanical energy from the diesel t~nginc 01 from regenerative braking to electrical energy. A vehicle control module...Distributed Heterogeneous Simulation of a Hybrid- Electric Vehicle Ning Wu’, Curtis Rands t , Charles E. Lucas!, Eric A. Walters§, and Maher A...Masrurit US Army RDECOM-TARDEC, Warren, MI, 48397 Hybrid- electric military vehicles provide many advantages over conventional military vehicles powered

  8. A Study of the Operating Room Scheduling System at Tripler Army Medical Center, Hawaii

    DTIC Science & Technology

    1981-08-01

    meaningful at this time. 𔃺ŕ Another limitation encountered involved the types of procedures . During the research, it was dis- covered that some highly...Data extracted from this form Si-]Atded: k󈨕rn- ning and ending aresthesis times, beginning and ending procedure times, the type of procedure ...physician, the names of both the procedures and the physicians, and the service chiefs’ 24 procedure time estimates. It also established the types of

  9. Future Seabasing Technology Analysis: Logistics Command and Control

    DTIC Science & Technology

    2006-08-01

    Center (CSSOC) System (ECS) - Asset management. "* Logistics Planning and Execution (Log(P/E)) - Mission plan- ning and unit readiness. Sapient ...base, was contracted to Sapient Corporation, the developer of CLC2S. Sapient states that its vision for the program is to develop a FORCEnet C2...all functions have been activated. Sapient has adopted a strategy of using workshops with subject matter experts to define the capabilities that need

  10. Identification and Quantitation of Anthocyanins in Purple-Fleshed Sweet Potatoes Cultivated in China by UPLC-PDA and UPLC-QTOF-MS/MS.

    PubMed

    He, Wei; Zeng, Maomao; Chen, Jie; Jiao, Yuzhi; Niu, Fuxiang; Tao, Guanjun; Zhang, Shuang; Qin, Fang; He, Zhiyong

    2016-01-13

    The identification and quantitation of the anthocyanins in 12 purple-fleshed sweet potato (PFSP) cultivars ('Jihei 1', 'Xuzi 3', 'Xuzi 6', 'Zhezi 4', 'Ningzi 1', 'Ningzi 2', 'Ningzi 3', 'Ning 2-2', 'Ning 6-8', 'Guangzi 1', 'Ziluolan', and 'Qinzi 1') in China were carried out using a combination of ultraperformance liquid chromatography-photodiode array (UPLC-PDA), quadrupole-time-of-flight mass spectrometry (QTOF-MS), and tandem mass spectrometry (MS/MS) analyses. Thirteen acylated anthocyanins were tentatively characterized, including two new PFSP anthocyanins, cyanidin 3-caffeoyl-vanilloyl sophoroside-5-glucoside and peonidin 3-caffeoyl-vanilloyl sophoroside-5-glucoside. The quantitative analyses of these anthocyanins were conducted using cyanidin 3-O-glucoside as a standard. The total anthocyanin content of the PFSPs depended on the cultivar. The five PFSP cultivars with the highest content of anthocyanins were 'Jihei 1', 'Xuzi 3', 'Zhezi 4', 'Ziluolan', and 'Qinzi 1'. This is the first report of the 'Ningzi 2', 'Ningzi 3', and 'Ning 2-2' PFSP cultivars containing only diacylated anthocyanins and of the 'Xuzi 6' cultivar containing single anthocyanidin-based anthocyanins.

  11. JPRS Report, Science & Technology, Europe

    DTIC Science & Technology

    2007-11-02

    were the first to develop the on-board computer (BUSZI) for the lander of the Phobos probe (see MAGYAR ELEK- TRONIKA, No 8 and No 9,1988). This was...orbital units of the Phobos probes launched in July 1988. An evaluation of the measurement data coming from space is already under way; the actual...in solving a number of earth tasks. Begin- ning in 1985 I worked in hardware and software design for the ESTER on-board equipment for the Phobos

  12. Preparation of Hemoglobin-Containing Microcapsules.

    DTIC Science & Technology

    1981-06-01

    were suspended in saline for storage in a refrigerator. Although in these microencapsulation experiments, the Hb was not denatured, the microcapsules ... microencapsulated Hb, l.O-ml sample of the microcapsule suspension was diluted with 10 ml 0.9% NaCI. The absorption spectrum was taken immediately after dilution...AD A135 634 PREPARATION OF HEMOGLOBIN CONTA NING MICROCAPSULES (U) I/ ,R 224 AM OS NTERNATIDNAL MENOPARKO CA REYES AUNN8 SRI-2254-1 DAMD17-80-C-01?7

  13. UC - A Progress Report.

    DTIC Science & Technology

    1986-07-01

    component of UC. Each com- ponent is illustrated on the processing of the sentence "Do you know how to print a file on the imagen *?" In some cases, a module...consider some of the patterns used to analyze the question "Do you know how to print a file on the imagen ?" These include <Aux> <NP> <VP>, whose...know how to print a file on the imagen ?" Read do you ALANA recognizes do as an Auxiliary and you as a pronoun, matching the begin- ning of the

  14. Deadlock Detection in Computer Networks

    DTIC Science & Technology

    1977-09-01

    rocess->ressii~frtx vrteoeao oncin Th e fpoesswiigfrtx vrteoperator connection.>rcs The nature of exclusive assignment of an operator connection to a...prooess", "last’, dboref); call write ait ’"Resource is not currently aviable for", cal exclu ive use, procesO , prooesqs 1; calwrite list nd" rond~ae...tprocess.namew); proc node-name =extract_(Ownerref, "node_table.name" ); /0 Check if the process ga --ning Rccess to the database object is In the same node as

  15. International Biodefense Enhancement Capabilities from a Policy Perspective

    DTIC Science & Technology

    2005-05-01

    1 no debe inferirse ning6n tipo de aval oficial. 17 W8 I XWH-04-C-0006 Figure 4. Hospital Self-Assessment Tool Question 1, Spanish version 2...radiol6gico 4 3 2 1 E/NP Accidente en una central de energia 4 3 2 1 E/NP nuclear Detonaci6n de un dispositivo radiol6gico 4 3 2 1 E/NP en el...y planeamiento y fuente : W8 I XWH-04-C-0006 17. ,Ha utilizado su organizaci6n algfin otro programa de preparaci6n, ademds de los propuestos en la Gui

  16. Air Force Environmental Management System Overview

    DTIC Science & Technology

    2011-05-01

    Key to ~:ning the environn ental portion of lbiJ vi ’lion i3 copcrot:oll41iling cnvirorunentlll monagcmcnt Air Force-wide. Operotiooa:tzl.o...approach for addressing environmental aspects of internal agency operations and activities”  For the AF, “appropriate facilities” equates to “major...y y y Authority 7. Communication y y y 16. Internal EMS Audit y y y 8. Documentation & y y y 17. Management Review y y y Doc Control 9

  17. United States Army in the Korean War: EBB and Flow, November 1950-July 1951

    DTIC Science & Technology

    1990-01-01

    country’s stionger neigh- rui , de:Iiled actKoun of giomnd upe : .ilun" ill ors. C"hina, Russia. ad Japan. Pas, rivaris amog Korea dulting 25June-4,[ November...also were canceled, ats wvas plall- at force of some ,553,000 men fr-om thie ning for at roll- up of suipplies in’ thle Republic of* Korea and...mining River, which for eleven miles up - forhcoin edavors to assure China st ream From its mouth mar’ks thle hot’- that the northern border of Korea was

  18. Generic Distributed Systems Model

    DTIC Science & Technology

    1989-03-01

    networking of microcomputers or work- stations with a distributed system and a clear distinction between the two needs to be made. What is expected in a...INFORM.AT1ON PERTAI NING TO LOCATIONS AND POLICY CAN BE COMBINED WITH THE INITIAL DIAGRAM TO PRODUCE A PARTITIONED DFD. THE BOLD LINES REPRESENT SERVICES WHICH...PRA85] D.K. Pradhan, "Fault-tolerant. mIltiprocessor link and bus network Architectures," IEEE Trans. on Computers, Vol. 34, No. I, Jan. 1985, pp. 33

  19. Comprehensive Approach Training Toolkit: Training Needs Analysis

    DTIC Science & Technology

    2013-03-01

    Compreh Emily-Ana Disclaimer: Technical Do ensive A Filardo, M PWGS Defence R This report ha cuments, 2nd E “ pproach ichael H. Th HumanSy 111...questio r report and dele n anywhere in th private sectors a ooks are a uniq re tailor-made a ilability is scarce t been any prev enerally provide ds... report , "An e Evaluation" fo culty, students promoting active racters involved ge 15 tice hly r in ilt l cting n ken ning, e heir s f

  20. Rapid Dominance: Integrating Space into Today’s Air Operations Center

    DTIC Science & Technology

    2000-04-01

    the United States Air Force to consider in preparation for the EAF—it provides a framework to educate JAOC and EAF personnel to more effectively...opera­ tions. The problem is that most JAOC personnel have not been educated on how space supports specific JAOC plan­ ning and operations, and “they...the 41 percent that did have some JAOC experience, only 43 percent were ever briefed or educated on JAOC space support products and ser­ vices

  1. What Democracy for Afghanistan? An Analysis Utilizing Established Norms and Five Non-Western Case Studies

    DTIC Science & Technology

    2009-09-01

    province public goods and services, monetary and fiscal management, law making, international relations, and internal rule of law, exercised in...Corruption in Nicaragua . For current information in Spanish see Revista Envío, www.envio.org.ni 161 “Informe Latinobarómetro 2008,” 44. 38...Caudillismo (Lanham: Lexington, 2004). 163 Revista Envío “Sin ningún borrón y con muchas cuentas nuevas” January 2009. 164 Michel Cahen, “Mozambique

  2. What Should the United States Foreign Policy be Towards Taiwan

    DTIC Science & Technology

    2007-11-02

    immigration to Taiwan started as early as 500 A.D. with Chinese prefecture rule being established over the island by the Qing Dynasty from 1680- 1875...Mainland China and Chiang Kai-shek’s Nationalist Chinese (Kuo Min Tang , or K.M.T.) established a provisional government on Taiwan.10 Taiwan was widely...Defense Minister Tang Yiau-ming to the U.S. -Taiwan 3 Business Council in March 2002 and by Vice Minister of Defense Kang Ning-hsiang to the Pentagon in

  3. Father and I

    NASA Astrophysics Data System (ADS)

    Yang, Chen Ning

    2013-05-01

    Father (K. C. Yang (楊克純), 1896-1973) was a high school teacher in Anqing (安慶) in 1922 when I was born in Hefei (合肥). Anqing was then also called Huaining (懷寧). Father gave me the name Chen Ning, of which Chen was the name of my generation in our family, and Ning was derived from Huaining. Before I was one year old Father won an Anhui (安徽) Provincial Fellowship for studying in the USA. We had a family picture (Figure 1) taken in the courtyard outside our bedroom a few days before he left home. Father had on the traditional robe and coat, standing stiff and erect. He had probably up to that point never worn a western suit. Two years later he sent a picture (Figure 2) to Mother from the University of Chicago, in which his attire and bearing had both entered the twentieth century. Father was a handsome man. The exuberance and optimism of his youth were clearly captured in this photograph...

  4. Dynamic defense workshop :

    SciTech Connect

    Crosby, Sean Michael; Doak, Justin E.; Haas, Jason Juedes.; Helinski, Ryan; Lamb, Christopher C.

    2013-02-01

    On September 5th and 6th, 2012, the Dynamic Defense Workshop: From Research to Practice brought together researchers from academia, industry, and Sandia with the goals of increasing collaboration between Sandia National Laboratories and external organizations, de ning and un- derstanding dynamic, or moving target, defense concepts and directions, and gaining a greater understanding of the state of the art for dynamic defense. Through the workshop, we broadened and re ned our de nition and understanding, identi ed new approaches to inherent challenges, and de ned principles of dynamic defense. Half of the workshop was devoted to presentations of current state-of-the-art work. Presentation topics included areas such as the failure of current defenses, threats, techniques, goals of dynamic defense, theory, foundations of dynamic defense, future directions and open research questions related to dynamic defense. The remainder of the workshop was discussion, which was broken down into sessions on de ning challenges, applications to host or mobile environments, applications to enterprise network environments, exploring research and operational taxonomies, and determining how to apply scienti c rigor to and investigating the eld of dynamic defense.

  5. [Efficacy and safety of initial treatment with glimpeiride versus sitagliptin in type 2 diabetes].

    PubMed

    Tamez-Pérez, Héctor Eloy

    2015-01-01

    Introducción: La diabetes mellitus tipo 2 (DM2) es una enfermedad multifactorial que puede ser abordada tanto con antidiabéticos orales como con insulina. Los antidiabéticos orales glimepirida y sitagliptina poseen mecanismos de acción diferentes que no se han comparado directamente en pacientes con DM2 de reciente diagnóstico en Latinoamérica. El objetivo primario de este estudio multicéntrico de 24 semanas, de dos brazos, randomizado (1:1) y abierto, en pacientes adultos con DM2 y niveles de hemoglobina glucosilada (HbA1c) > 8.5 % < 11 %, fue comparar la eficacia de glimepirida con sitagliptina en pacientes adultos vírgenes de tratamiento. Como objetivos secundarios se compararon los efectos sobre la glucosa plasmática de ayuno y postprandial, hipoglucemia, cambio de peso, porcentaje de pacientes que se retiraron del protocolo, la seguridad de ambos tratamientos, signos vitales y resultados de laboratorio. Resultados: No se encontraron diferencias significativas en la eficacia de ambos medicamentos en el control de glucosa, ni en ningún otro parámetro, con la excepción de la incidencia de hipoglucemia, que se reportó con una frecuencia significativamente mayor en los pacientes del grupo de glimepirida. No existieron fatalidades en ningún grupo. Conclusiones: Se concluye que la monoterapia de glimepirida y sitagliptina reducen niveles de HbA1c con eficacia similar.

  6. Al-doping influence on crystal growth of Ni-Al alloy: Experimental testing of a theoretical model

    NASA Astrophysics Data System (ADS)

    Rong, Xi-Ming; Chen, Jun; Li, Jing-Tian; Zhuang, Jun; Ning, Xi-Jing

    2015-12-01

    Recently, a condensing potential model was developed to evaluate the crystallization ability of bulk materials [Ye X X, Ming C, Hu Y C and Ning X J 2009 J. Chem. Phys. 130 164711 and Peng K, Ming C, Ye X X, Zhang W X, Zhuang J and Ning X J 2011 Chem. Phys. Lett. 501 330], showing that the best temperature for single crystal growth is about 0.6Tm, where Tm is the melting temperature, and for Ni-Al alloy, more than 6 wt% of Al-doping will badly reduce the crystallization ability. In order to verify these predictions, we fabricated Ni-Al films with different concentrations of Al on Si substrates at room temperature by pulsed laser deposition, and post-annealed the films at 833, 933, 1033 (˜ 0.6Tm), 1133, and 1233 K in vacuum furnace, respectively. The x-ray diffraction spectra show that annealing at 0.6Tm is indeed best for larger crystal grain formation, and the film crystallization ability remarkably declines with more than 6-wt% Al doping. Project supported by the Specialized Research Fund for the Doctoral Program of Higher Education, China (Grant No. 20130071110018) and the National Natural Science Foundation of China (Grant No. 11274073).

  7. Early Development of Four Cyprinids Native to the Yangtze River, China

    USGS Publications Warehouse

    Chapman, Duane C.

    2006-01-01

    Chapter 1 -- Notes on the Translation and Use of "A Study of the Early Development of Grass Carp, Black Carp, Silver Carp, and Bighead Carp in the Yangtze River, China" By Duane C. Chapman and Ning Wang Chapter 2 -- A Study of the Early Development of Grass Carp, Black Carp, Silver Carp, and Bighead Carp in the Yangtze River, China By Bolu Yi, Zhishen Liang, Zhitang Yu, Randuan Lin, and Mingjue HeTranslated by Duane C. Chapman and Ning Wang The document A Study of the Early Development of Grass Carp, Black Carp, Silver Carp, and Bighead Carp in the Yangtze River, China (Chapter 2 of this volume) was translated from the Chinese with the approval and assistance of the living authors of that study. It contains the most detailed description available, and approximately 200 drawings, of the early development of the subject fishes. Chapter 1 provides important instructions on the use of the translation, including a description of the Chinese morphometric conventions, which differ from those used by North American scientists. Chapter 1 also provides the historical context in which Chapter 2 was developed, and information on how the larvae of the subject fishes, which have invaded the Mississippi River basin, may be distinguished from other fishes present in the basin.

  8. Enhanced arbovirus surveillance with deep sequencing: Identification of novel rhabdoviruses and bunyaviruses in Australian mosquitoes.

    PubMed

    Coffey, Lark L; Page, Brady L; Greninger, Alexander L; Herring, Belinda L; Russell, Richard C; Doggett, Stephen L; Haniotis, John; Wang, Chunlin; Deng, Xutao; Delwart, Eric L

    2014-01-05

    Viral metagenomics characterizes known and identifies unknown viruses based on sequence similarities to any previously sequenced viral genomes. A metagenomics approach was used to identify virus sequences in Australian mosquitoes causing cytopathic effects in inoculated mammalian cell cultures. Sequence comparisons revealed strains of Liao Ning virus (Reovirus, Seadornavirus), previously detected only in China, livestock-infecting Stretch Lagoon virus (Reovirus, Orbivirus), two novel dimarhabdoviruses, named Beaumont and North Creek viruses, and two novel orthobunyaviruses, named Murrumbidgee and Salt Ash viruses. The novel virus proteomes diverged by ≥ 50% relative to their closest previously genetically characterized viral relatives. Deep sequencing also generated genomes of Warrego and Wallal viruses, orbiviruses linked to kangaroo blindness, whose genomes had not been fully characterized. This study highlights viral metagenomics in concert with traditional arbovirus surveillance to characterize known and new arboviruses in field-collected mosquitoes. Follow-up epidemiological studies are required to determine whether the novel viruses infect humans.

  9. Coltiviruses and Seadornaviruses in North America, Europe, and Asia

    PubMed Central

    Jaafar, Fauziah Mohd; de Micco, Philippe; de Lamballerie, Xavier

    2005-01-01

    Coltiviruses are tickborne viruses of the genus Coltivirus. The type species, Colorado tick fever virus (from North America), has been isolated from patients with flulike syndromes, meningitis, encephalitis, and other severe complications. Another coltivirus, Eyach virus, has been isolated from ticks in France and Germany and incriminated in febrile illnesses and neurologic syndromes. Seadornaviruses are endemic in Southeast Asia, particularly Indonesia and China. The prototype virus of the genus, Banna virus (BAV), has been isolated from many mosquito species, humans with encephalitis, pigs, and cattle. Two other seadornaviruses, Kadipiro and Liao Ning, were isolated only from mosquitoes. The epidemiology of seadornaviruses remains poorly documented. Evidence suggests that BAV is responsible for encephalitis in humans. Infection with BAV may be underreported because it circulates in regions with a high incidence of Japanese encephalitis and could be misdiagnosed as this disease. PMID:16318717

  10. Nursing competency and organizational climate as perceived by staff nurses in a Chinese university hospital.

    PubMed

    Ying, Liu; Kunaviktikul, Wipada; Tonmukayakal, Ouyporn

    2007-09-01

    Nursing competency is important to ensure patient safety and improve the quality of nursing care. Based on competency-based human resource management strategies, the organizational climate can positively influence nursing competency. However, a review of the literature indicated that there were no studies about the relationship between nursing competency and organizational climate in the People's Republic of China. This descriptive, correlational study examined the relationship between nursing competency and the organizational climate. The sample consisted of 243 staff nurses who completed the questionnaire worked at one university hospital in Liao Ning Province. The findings showed that there was a significantly moderate positive relationship between nursing competency and organizational climate. The study results suggested that Chinese nurse managers should maintain and provide a positive organizational climate to improve nursing competency.

  11. Les infections à Pseudomonas aeruginosa au service des maladies infectieuses du CHU YO, Burkina Faso: à propos deux cas

    PubMed Central

    Mamoudou, Savadogo; Lassina, Dao; Fla, Koueta

    2015-01-01

    Nous rapportons deux cas d'infection à Pseudomonas aeruginosa: un cas de méningite et un cas d'infection urinaire. Les auteurs rappellent qu’à côté des étiologies classiques des méningites et des infections urinaires, des germes résistants comme Pseudomonas aeruginosa peuvent être responsables d'infections à localisation méningées et urinaires et dont il faut connaître pour une bonne prise en charge. Le traitement de ces infections requiert un antibiogramme au regard de la grande capacité de résistance de Pseudomonas aeruginosa en milieu hospitalier. La limitation des gestes invasifs et l'application rigoureuse des mesures de prévention des infections en milieu hospitalier contribueront à lutter efficacement contre ces infections en milieu de soins. PMID:26491521

  12. Enhanced arbovirus surveillance with deep sequencing: identification of novel rhabdoviruses and bunyaviruses in Australian mosquitoes

    PubMed Central

    Coffey, Lark L.; Page, Brady L.; Greninger, Alexander L.; Herring, Belinda L.; Russell, Richard C.; Doggett, Stephen L.; Haniotis, John; Wang, Chunlin; Deng, Xutao; Delwart, Eric L.

    2013-01-01

    Viral metagenomics characterizes known and identifies unknown viruses based on sequence similarities to any previously sequenced viral genomes. A metagenomics approach was used to identify virus sequences in Australian mosquitoes causing cytopathic effects in inoculated mammalian cell cultures. Sequence comparisons revealed strains of Liao Ning virus (Reovirus, Seadornavirus), previously detected only in China, livestock-infecting Stretch Lagoon virus (Reovirus, Orbivirus), two novel dimarhabdoviruses, named Beaumont and North Creek viruses, and two novel orthobunyaviruses, named Murrumbidgee and Salt Ash viruses. The novel virus proteomes diverged by ≥50% relative to their closest previously genetically characterized viral relatives. Deep sequencing also generated genomes of Warrego and Wallal viruses, orbiviruses linked to kangaroo blindness, whose genomes had not been fully characterized. This study highlights viral metagenomics in concert with traditional arbovirus surveillance to characterize known and new arboviruses in field-collected mosquitoes. Follow-up epidemiological studies are required to determine whether the novel viruses infect humans. PMID:24314645

  13. A Digest of Reports Concerning the Toxic Effect of Phosgene on Man and the Laboratory Animals

    DTIC Science & Technology

    1922-05-01

    Mel in gloms.rular oapsulec cteequana U on of ep1 ~el1aJ. 11ni:ng ~ .8~ Oapau.le; epU:.nelilD BOla !lt1mes granular and. ~ine. (b) fubul.M I ip1 tb...ell• Ola ~on llD!1 Oglesb1• .a.M. ~a • .f.l.~. Tll.t-~9. J𔃻r1rc a LiTe.na :proJsotile loaded wi tl1 ph.ltr,’ltne and p\\ald.oe. a. Ob,W2t• ~ f1ud...A:J.itU. .u . i. XUhn1 R1ohtGJ"• Jh#rell, Ola ,7tou. 11. ~. Vl.U • .ir..31i).i• .B.ll. m.II-93. a. 2WtA’• Stwiy ~· perd.ate.noy &:ft4 lethal area

  14. Surprisingly Large Generation and Retention of Helium and Hydrogen in Pure Nickel Irradiated at High Temperatures and High Neutron Exposures

    SciTech Connect

    Greenwood, Lawrence R.; Garner, Francis A.; Oliver, Brian M.; Grossbeck, Martin L.; Wolfer, W. G.

    2004-04-01

    Hydrogen and helium measurements in pure nickel irradiated to 100 dpa in HFIR at temperatures between 300 and 600C show higher gas concentrations than predicted from fast-neutron reactions and the two-step 58Ni(n,g)59Ni(n,p and n,a) reactions. This additional gas production suggests previously unidentified nuclear sources of helium and possibly hydrogen that assert themselves at very high neutron exposure. The elevated hydrogen measurements are especially surprising since it is generally accepted that hydrogen is very mobile in nickel at elevated temperatures and therefore is easily lost, never reaching large concentrations. However, it appears that relatively large hydrogen concentrations can be reached and retained for many years after irradiation at reactor-relevant temperatures. These new effects may have a significant impact on the performance of nickel-bearing alloys at high neutron fluences in both fission and fusion reactor irradiations.

  15. Designing a road map for geoscience workflows

    NASA Astrophysics Data System (ADS)

    Duffy, Christopher; Gil, Yolanda; Deelman, Ewa; Marru, Suresh; Pierce, Marlon; Demir, Ibrahim; Wiener, Gerry

    2012-06-01

    Advances in geoscience research and discovery are fundamentally tied to data and computation, but formal strategies for managing the diversity of models and data resources in the Earth sciences have not yet been resolved or fully appreciated. The U.S. National Science Foundation (NSF) EarthCube initiative (http://earthcube.ning.com), which aims to support community-guided cyberinfrastructure to integrate data and information across the geosciences, recently funded four community development activities: Geoscience Workflows; Semantics and Ontologies; Data Discovery, Mining, and Integration; and Governance. The Geoscience Workflows working group, with broad participation from the geosciences, cyberinfrastructure, and other relevant communities, is formulating a workflows road map (http://sites.google.com/site/earthcubeworkflow/). The Geoscience Workflows team coordinates with each of the other community development groups given their direct relevance to workflows. Semantics and ontologies are mechanisms for describing workflows and the data they process.

  16. Capillary-Induced Self-Organization of Soft Pillar Arrays into Moir'e Patterns by Dynamic Feedback Process

    NASA Astrophysics Data System (ADS)

    Kang, Sung; Wu, Ning; Grinthal, Alison; Aizenberg, Joanna

    2012-02-01

    We report a self-organized pattern formation of polymer nanopillar arrays by dynamic feedback: two nanopillar arrays collectively structure a sandwiched liquid and pattern the menisci, which bend the pillars into Moir'e patterns as it evaporates. Like the conventional Moir'e phenomenon, the patterns are deterministic and tunable by mismatch angle, yet additional behaviors---chirality from achiral starting motifs and preservation of the patterns after the surfaces are separated---appear from the feedback process. Patterning menisci based on this mechanism provides a simple, scalable approach for making a series of complex, long-range-ordered structures. Reference: Sung H. Kang, Ning Wu, Alison Grinthal, and Joanna Aizenberg, Phys. Rev. Lett., 107, 177802 (2011).

  17. Climate Impacts on Tropospheric Ozone and Hydroxyl

    NASA Technical Reports Server (NTRS)

    Shindell, Drew T.; Bell, N.; Faluvegi, G.

    2003-01-01

    Climate change may influence tropospheric ozone and OH via several main pathways: (1) altering chemistry via temperature and humidity changes, (2) changing ozone and precursor sources via surface emissions, stratosphere-troposphere exchange, and light- ning, and (3) affecting trace gas sinks via the hydrological cycle and dry deposition. We report results from a set of coupled chemistry-climate model simulations designed to systematically study these effects. We compare the various effects with one another and with past and projected future changes in anthropogenic and natural emissions of ozone precursors. We find that white the overall impact of climate on ozone is probably small compared to emission changes, some significant seasonal and regional effects are apparent. The global effect on hydroxyl is quite large, however, similar in size to the effect of emission changes. Additionally, we show that many of the chemistry-climate links that are not yet adequately modeled are potentially important.

  18. The Current Use of Social Media in Undergraduate Nursing Education: A Review of the Literature.

    PubMed

    Ross, Jennifer Gunberg; Myers, Shannon Marie

    2017-03-11

    Social media, including blogs, Twitter, wikis, Facebook, YouTube, and Ning, provides an opportunity for nurse educators to engage undergraduate nursing students who are members of the millennial generation in active learning while enhancing knowledge and fostering communication. Despite the rise of social media usage in undergraduate nursing education, there is a significant deficiency of empirical evidence supporting the efficacy and outcomes of these teaching strategies. This article provides an overview of social media use in undergraduate nursing education and a review of the existing research related to social media use in prelicensure nursing education. Overall, undergraduate nursing students respond positively to social media use in nursing education; however, no outcome measures are available to determine the effect of these teaching strategies on student learning.

  19. Ohm's law survives to the atomic scale.

    PubMed

    Weber, B; Mahapatra, S; Ryu, H; Lee, S; Fuhrer, A; Reusch, T C G; Thompson, D L; Lee, W C T; Klimeck, G; Hollenberg, L C L; Simmons, M Y

    2012-01-06

    As silicon electronics approaches the atomic scale, interconnects and circuitry become comparable in size to the active device components. Maintaining low electrical resistivity at this scale is challenging because of the presence of confining surfaces and interfaces. We report on the fabrication of wires in silicon--only one atom tall and four atoms wide--with exceptionally low resistivity (~0.3 milliohm-centimeters) and the current-carrying capabilities of copper. By embedding phosphorus atoms within a silicon crystal with an average spacing of less than 1 nanometer, we achieved a diameter-independent resistivity, which demonstrates ohmic scaling to the atomic limit. Atomistic tight-binding calculations confirm the metallicity of these atomic-scale wires, which pave the way for single-atom device architectures for both classical and quantum information processing.

  20. A study of the turn-up effect in the electron momentum spectroscopy

    NASA Astrophysics Data System (ADS)

    Dal Cappello, C.; Menas, F.; Houamer, S.; Popov, Yu V.; Roy, A. C.

    2015-10-01

    Recently, a number of electron momentum spectroscopy measurements for the ionization of atoms and molecules have shown that the triple differential cross section (TDCS) has an unexpected higher intensity in a low momentum regime (Brunger M J, Braidwood S W, Mc Carthy I E and Weigold E 1994 J. Phys. B: At. Mol. Opt. Phys. 27 L597, Hollebone B P, Neville J J, Zheng Y, Brion C E, Wang Y and Davidson E R 1995 Chem. Phys. 196 13, Brion C E, Zheng Y, Rolke J, Neville J J, McCarthy I E and Wang J 1998 J. Phys. B: At. Mol. Opt. Phys. 31 L223, Ren X G, Ning C G, Deng J K, Zhang S F, Su G L, Huang F and Li G Q 2005 Phys. Rev. Lett. 94 163201, Deng J K, et al 2001 J. Chem. Phys. 114 882, Ning C G, Ren X G, Deng J K, Su G L, Zhang S F and Li G Q 2006 Phys. Rev. A 73 022704). This surprising result is now called the turn-up effect. Our aim is to investigate such an effect by studying the case of the ionization of atomic hydrogen in an excited state using the 3C model (Brauner M, Briggs J S and Klar H 1989 J. Phys. B: At. Mol. Opt. Phys. 22 2265) which is able to describe all the measured results of the single ionization of atomic hydrogen in its ground state for an incident energy beyond 200 eV. A comparison is also made of the findings of the present method with those of the plane wave impulse approximation and distorted wave models.

  1. Analysis of point source pollution and water environmental quality variation trends in the Nansi Lake basin from 2002 to 2012.

    PubMed

    Wang, Weiliang; Liu, Xiaohui; Wang, Yufan; Guo, Xiaochun; Lu, Shaoyong

    2016-03-01

    Based on the data analysis of the water environmental quality and economic development from 2002 to 2012 in the Nansi Lake basin, the correlation and change between the water environmental quality and economic development were studied. Results showed that the GDP and wastewater emissions of point source in the Nansi Lake basin had an average annual growth of 7.30 and 7.68 %, respectively, from 2002 to 2012. The emissions of chemical oxygen demand (COD) and ammonia nitrogen (NH3-N) had the average annual decrease of 7.69 and 6.79 % in 2012, respectively, compared to 2002. Basin water quality overall improved, reaching the Class III of the "Environmental quality standards for surface water (GB3838-2002)," in which the main reason was that sewage treatment rate increased gradually and was above 90 % in 2012 (an increase of 10 % compared to 2002) with the progress of pollution abatement technology and the implementation of relevant policies and regulations. The contribution of water environmental pollution was analyzed from related cities (Ji'ning, Zaozhuang, Heze). Results indicated that Ji'ning had the largest contribution to water pollution of the Nansi Lake basin, and the pollutant from domestic sources accounted for a higher percentage compared to industrial sources. The wastewater, COD, and NH3-N mainly came from mining and washing of coal, manufacture of raw chemical materials and chemical products, papermaking industry, and food processing industry. According to the water pollution characteristics of the Nansi Lake basin, the basin pollution treatment strategy and prevention and treatment system were dissected to provide a scientific basis for prevention and control of lakeside point source pollution along the Nansi Lake.

  2. Vibrational Spectroscopy of Transient Dipolar Radicals via Autodetachment of Dipole-Bound States of Cold Anions

    NASA Astrophysics Data System (ADS)

    Huang, Dao-Ling; Liu, Hong-Tao; Dau, Phuong Diem; Wang, Lai-Sheng

    2014-06-01

    . 137, 116101 (2012). 4 I. Leon, Z. Yang, and L. S. Wang, J. Chem. Phys. 138, 184304 (2013). 5 H. T. Liu, C. G. Ning, D. L. Huang, P. D. Dau, and L. S. Wang, Angew. Chem. Int. Ed. 52, 8976 (2013). 6 H. T. Liu, C. G. Ning, D. L. Huang, and L. S. Wang, Angew. Chem. Int. Ed. (accepted)

  3. [Assessing the profile and nutritional intake of an Ibero-American group of nutrition postgraduate students].

    PubMed

    Sumalla Cano, Sandra; Elío, Iñaki; Domínguez, Irma; Calderón, Rubén; García, Agueda; Fernández, Federico; Gracia, Santos; Dzul, Luis; Battino, Maurizio; Solano, Héctor Antonio

    2013-01-01

    Introducción: Los hábitos alimentarios tienen una gran influencia sobre la salud de las personas, por ello es de suma importancia profundizar en su estudio para comprobar su adaptación a las recomendaciones actuales y poder realizar políticas de educación nutricional y/o suplementación ajustadas a la realidad. Material y métodos: Estudio transversal descriptivo con la colaboración de estudiantes de postgrado. Los participantes se seleccionaron mediante muestreo no probabilístico accidental enviando vía mail la información del estudio, realizado mediante un cuestionario sobre sus características socio-demográficas y un registro dietético de 3 días. La muestra estuvo formada por n = 50 participantes. Los registros dietéticos de 3 días se valoraron con el software NutrIber y los datos obtenidos fueron tratados mediante el software estadístico SPSS 15. Resultados y discusión: El perfil de los estudiantes es de 80% mujeres y 20% hombres, con edad media de 33,7 ± 9,32 AÑOs, e índice de masa corporal de 22,91 ± 4,07. Todos los grupos presentan un consumo excesivo de proteínas y lípidos y deficitario en glúcidos. En cuanto a los micronutrientes es destacable que ningún grupo cubre las ingestas recomendadas de yodo, y que ningún grupo de mujeres cubre las recomendaciones de ingesta de fibra, ácido fólico ni hierro. Conclusiones: Son necesarios más estudios para confirmar los resultados hallado, sin embargo, se puede concluir que las poblaciones urbanas de Latinoamérica cada vez se acercan más al modelo de dieta occidental, rica en proteínas y grasas y pobre en glúcidos, fibra y micronutrientes, lo que es indicativo de dietas pobres en cereales integrales, frutas y verduras.

  4. Optical system for tablet variety discrimination using visible/near-infrared spectroscopy

    NASA Astrophysics Data System (ADS)

    Shao, Yongni; He, Yong; Hu, Xingyue

    2007-12-01

    An optical system based on visible/near-infrared spectroscopy (Vis/NIRS) for variety discrimination of ginkgo (Ginkgo biloba L.) tablets was developed. This system consisted of a light source, beam splitter system, sample chamber, optical detector (diffuse reflection detector), and data collection. The tablet varieties used in the research include Da na kang, Xin bang, Tian bao ning, Yi kang, Hua na xing, Dou le, Lv yuan, Hai wang, and Ji yao. All samples (n=270) were scanned in the Vis/NIR region between 325 and 1075 nm using a spectrograph. The chemometrics method of principal component artificial neural network (PC-ANN) was used to establish discrimination models of them. In PC-ANN models, the scores of the principal components were chosen as the input nodes for the input layer of ANN, and the best discrimination rate of 91.1% was reached. Principal component analysis was also executed to select several optimal wavelengths based on loading values. Wavelengths at 481, 458, 466, 570, 1000, 662, and 400 nm were then used as the input data of stepwise multiple linear regression, the regression equation of ginkgo tablets was obtained, and the discrimination rate was researched 84.4%. The results indicated that this optical system could be applied to discriminating ginkgo (Ginkgo biloba L.) tablets, and it supplied a new method for fast ginkgo tablet variety discrimination.

  5. Hot-hole injection probabilities into the insulator of metal-insulator-silicon devices

    NASA Astrophysics Data System (ADS)

    Hellouin, Y.; Chehade, F.; Garrigues, M.

    1987-06-01

    The probability of hot-hole injection has been measured both on metal nitride-oxide silicon (MNOS) and metal-oxide-semiconductor (MOS) structures in the case where the silicon electric field is one dimensional and normal to the interface. The experiment uses the effect of optically induced hot carrier injection as proposed by Ning et al. [J. Appl. Phys. 48, 286 (1977)]. In the case of MNOS structures, the hot-hole injection currents can be readily measured because the Si-Si3N4 interface barrier is lower than the Si-SiO2 interface barrier. Measurements on MOS structures were carried out using heavily doped silicon. The measurements have been interpreted using the lucky carrier model with some modifications: the hot-hole mean-free path has been found equal to 41±5 Å in the case of MOS structures. Taking into account the accuracy of the measurements, this value is compatible with the value derived in the case of MNOS structures and also with the value derived from ionization measurements.

  6. Probing the Vibrational Spectroscopy of the Deprotonated Thymine Radical by Photodetachment and State-Selective Autodetachment Photoelectron Spectroscopy via Dipole-Bound States

    NASA Astrophysics Data System (ADS)

    Huang, Dao-Ling; Zhu, Guo-Zhu; Wang, Lai-Sheng

    2016-06-01

    Deprotonated thymine can exist in two different forms, depending on which of its two N sites is deprotonated: N1[T-H]^- or N3[T-H]^-. Here we report a photodetachment study of the N1[T-H]^- isomer cooled in a cryogenic ion trap and the observation of an excited dipole-bound state. Eighteen vibrational levels of the dipole-bound state are observed, and its vibrational ground state is found to be 238 ± 5 wn below the detachment threshold of N1[T-H]^-. The electron affinity of the deprotonated thymine radical (N1[T-H]^.) is measured accruately to be 26 322 ± 5 wn (3.2635 ± 0.0006 eV). By tuning the detachment laser to the sixteen vibrational levels of the dipole-bound state that are above the detachment threshold, highly non-Franck-Condon resonant-enhanced photoelectron spectra are obtained due to state- and mode-selective vibrational autodetachment. Much richer vibrational information is obtained for the deprotonated thymine radical from the photodetachment and resonant-enhanced photoelectron spectroscopy. Eleven fundamental vibrational frequencies in the low-frequency regime are obtained for the N1[T-H]^. radical, including the two lowest-frequency internal rotational modes of the methyl group at 70 ± 8 wn and 92 ± 5 wn. D. L. Huang, H. T. Liu, C. G. Ning, G. Z. Zhu and L. S. Wang, Chem. Sci., 6, 3129-3138 (2015)

  7. [Spectrometric determination of trace elements in anticancer new medicine Fagopyrum dibotrys].

    PubMed

    Wang, Ji-Yong; Wang, Yuan-Zhong; Zeng, Yan; Li, Jin-Tong

    2011-01-01

    The golden buckwheat Fagopyrum dibotrys produced in Yunnan has a unique anti-cancer effects. It is a main raw material of "Wei Mai ning" capsules which is the national second-class anti-cancer drug. The present paper used (5 : 1) mixed acid as digestive juice to process the sample, and determine the twelve elements including K, Ca, Cu, Na, Mg, Mn, Fe, Zn, Pb, Cr, Cd and Co in the Fagopyrum dibotrys by inductively coupled plasma atomic emission spectrometry(ICP-AES). The detection limits of this method were 0.017-0.084 microg x mL(-1), the RSDs (n = 8) were all 0.09%-1.87%, and the addition standard recoveries(ASR) (n = 8) were 98.2%-107.4% for all elements. The research results showed that there is rich K(1 477.3 microg x g(-1)) in the Fagopyrum dibotrys, there are not harmful elements Cd and Pb, and this result is mainly related to the geochemistry background where the sample lived. The contents of seven remaining kinds of elements ranked as Na (826.1) > Ca (765.2 > Mg (493.4) > Zn (112.7) > Fe (56.5) > Cu (11.4) > Mn (4.49 microg x g(-1)). This result provides some theoretical basis for the study of internal relations between trace elements in Fagopyrum dibotrys and efficacy. It' s also useful for better development and utilization of the resource.

  8. Social networking in nursing education: integrative literature review

    PubMed Central

    Kakushi, Luciana Emi; Évora, Yolanda Dora Martinez

    2016-01-01

    Abstract Objective: to identify the use of social networking in nursing education. Method: integrative literature review in the databases: LILACS, IBECS, Cochrane, BDENF, SciELO, CINAHL, Scopus, PubMed, CAPES Periodicals Portal and Web of Science, using the descriptors: social networking and nursing education and the keywords: social networking sites and nursing education, carried out in April 2015. Results: of the 489 articles found, only 14 met the inclusion and exclusion criteria. Most studies were published after 2013 (57%), originating from the United States and United Kingdom (77.8%). It was observed the use of social networking among nursing students, postgraduate students, mentors and nurses, in undergraduate programmes, hybrid education (blended-learning) and in interprofessional education. The social networking sites used in the teaching and learning process were Facebook (42.8%), Ning (28.5%), Twitter (21.4%) and MySpace (7.1%), by means of audios, videos, quizzes, animations, forums, guidance, support, discussions and research group. Conclusion: few experiences of the use of social networking in nursing education were found and their contributions show the numerous benefits and difficulties faced, providing resourses for the improvement and revaluation of their use in the teaching and learning process. PMID:27384465

  9. [CAFFEINE AND QUININE IN SOFT DRINKS; CONTRIBUTION TO THE DIETARY INTAKE].

    PubMed

    González Reyes, Ana Belén; Hardisson de la Torre, Arturo; Gutiérrez Fernández, Angel José; Rubio Armendáriz, Carmen; Frías Tejera, Inmaculada; Revert Gironés, Consuelo

    2015-12-01

    Introducción: las bebidas refrescantes son cada vez más consumidas por la sociedad. Están compuestas por una gran variedad de sustancias, de las cuales algunas, si se consumen en dosis altas y con elevada frecuencia, pueden provocar efectos negativos. Objetivos: determinar la concentración de cafeína y quinina para comprobar si sus niveles se encuentran por debajo de los máximos permitidos por la reglamentación técnico-sanitaria vigente y calcular la contribución a la ingesta dietética obteniendo la Ingesta Diaria Estimada. Método: se analizaron las concentraciones de cafeína y quinina en las principales marcas comerciales de refrescos, usando para ello la técnica de cromatografía líquida de alta resolución. Resultados: se obtuvieron concentraciones para todas las marcas analizadas, que permitieron estimar la media en cada una. Conclusiones: se ha observado que en ningún caso se superan las concentraciones máximas y que la contribución a la ingesta no genera aparición alguna de reacción adversa.

  10. Molecular characterization of segments S7 to S10 of a southern rice black-streaked dwarf virus isolate from maize in northern China.

    PubMed

    Yin, Xiao; Xu, Fei-fei; Zheng, Fang-qiang; Li, Xiang-dong; Liu, Bao-shen; Zhang, Chun-qing

    2011-02-01

    Southern rice black-streaked dwarf virus (SRBSDV) is a novel Fijivirus prevalent in rice in southern and central China, and northern Vietnam. Its genome has 10 segments of double-stranded RNA named S1 to S10 according to their size. An isolate of SRBSDV, JNi4, was obtained from naturally infected maize plants from Ji'ning, Shandong province, in the 2008 maize season. Segments S7 to S10 of JNi4 share nucleotide identities of 72.6%-73.1%, 72.3%-73%, 73.9%-74.5% and 77.3%-79%, respectively, with corresponding segments of Rice black-streaked dwarf virus isolates, and identities of 99.7%, 99.1%-99.7%, 98.9%-99.5%, and 98.6%-99.2% with those of SRBSDV isolates HN and GD. JNi4 forms a separate branch with GD and HN in the phylogenetic trees constructed with genomic sequences of S7 to S10. These results confirm the proposed taxonomic status of SRBSDV as a distinct species of the genus Fijivirus and indicate that JNi4 is an isolate of SRBSDV. Shandong is so far the northernmost region where SRBSDV is found in China.

  11. Faraday current sensing employing chromatic modulation

    NASA Astrophysics Data System (ADS)

    Jones, G. R.; Li, G.; Spencer, J. W.; Aspey, R. A.; Kong, M. G.

    1998-01-01

    Faraday current sensors using a variety of sensing elements have been investigated extensively for their high sensitivity as well as other advantages [G.L. Lewis et al., Proc. IEE Conf. on The Reliability of Transmission and Distribution Equipment, 1995; Y.N. Ning et al., Optics Lett. 16 (1991); C.M.M. van den Tempel, Appl. Optics 32 (1993)]. Concurrently chromatic modulation techniques have been investigated at the University of Liverpool for use with optical fibre sensors of different types [N.A. Pilling, Ph.D. Thesis, 1992; M.M. Murphy, Ph.D. Thesis, 1991] including Faraday current sensing, for overcoming difficulties with non-referenced intensity modulation systems. In this contribution a brief discussion of the scope of chromatically based Faraday current sensing with particular regard to electric power transmission and distribution industries is given. A novel sensor based upon a Faraday glass block in combination with a BSO crystal in the sensing element is described. The sensor takes advantage of the natural gyrotropy of the BSO which conversely has been previously regarded as a disadvantage. The experimental results obtained indicate that this method offers a novel approach to improving system sensitivity. The extension of the approach from a simple bench top demonstrator to real power systems deployment is also discussed.

  12. Traditional Chinese and Indian medicine in the treatment of opioid-dependence: a review

    PubMed Central

    Doosti, Fatemeh; Dashti, Saeedeh; Tabatabai, Seyed Meghdad; Hosseinzadeh, Hossein

    2013-01-01

    Objective: In this study, the current literatures on the use of herbs and herbal preparations of Traditional Chinese and Indian Medicine for the treatment of opioid addiction were reviewed. Matherials and Methods: Search was done in databases such as Pub Med, Science Direct, Scopus, Springer Link, and Google Scholar. Results: Among 18 retrieved studies, 3 studies were about asafetida extract, an approved preparation for ameliorating drug abstinence in China. Chinese preparations including Composite Dong Yuan Gao, Qingjunyin and TJ-97 (a water extract of dai-bofu-to) as well as Indian ones, Mentate and Shilajit, were reported to have positive effects against opioid withdrawal, dependence, and tolerance. Moreover, Levo-tetrahydropalmatine and L-Stepholidine, in addition to extracts of Caulis Sinomenii and Sinomenium acutum showed similar effects. Banxia Houpu Decoction, Fu-Yuan pellet, Jinniu capsules, Qingjunyin, Tai-Kang-Ning capsule, and Xuan Xia Qudu Jiaonang (WeiniCom) from Chinese preparations, showed anti-addiction effects in randomized, double-blind and, in some studies, multicenter clinical trials. Conclusion : Traditional herbal preparations of China and India have anti-addiction effects with less adverse effects than alpha2-adrenergic or opioid agonists. PMID:25050276

  13. Utilization of Lightning Data for Recognition and Nowcasting of Severe Thunderstorms

    NASA Astrophysics Data System (ADS)

    Betz, Hans D.

    2010-05-01

    Technological disasters and hazardous natural threats are often correlated or even caused by severe thunderstorms. In particular, when a disaster has happened and subsequent human actions of various kinds are activated, it may be helpful to become aware of severe thunderstorms in the area concerned. For example, airports become closed and squadrons working in the open air are called back when lightning threats are expected or do occur. Although thunderstorm recognition and short-term prediction is not considered as a one of the primary subjects in connection with technological dis-asters, it represents background information that should be available in any case, and with high reliability. The present contribution summarizes the status of storm detection and demonstrates the features of the largest lightning location network in Europe (LINET), developed by the Physics Department of the University of Munich, and operated by nowcast GmbH in Munich. Some of the outstanding features of LINET are briefly highlighted. Further-more, it is explained how nowcasting of storms is achieved with the use of only light-ning data, and in combination with radar and other meteorological data sources. Re-sults of co-operations with other research groups, mainly with DLR (Deutsche Luft- und Raumfahrt), and within the project RegioExAKT, funded by the German Government in order to improve nowcasting at airports, are detailed.

  14. Trait contributions to fish community assembly emerge from trophicinteractions in an individual-based model

    USGS Publications Warehouse

    Giacomini, Henrique C.; DeAngelis, Donald; Trexler, Joel C.; Petrere, Miguel

    2013-01-01

    Community ecology seeks to understand and predict the characteristics of communities that can develop under different environmental conditions, but most theory has been built on analytical models that are limited in the diversity of species traits that can be considered simultaneously. We address that limitation with an individual-based model to simulate assembly of fish communities characterized by life history and trophic interactions with multiple physiological tradeoffs as constraints on species performance. Simulation experiments were carried out to evaluate the distribution of 6 life history and 4 feeding traits along gradients of resource productivity and prey accessibility. These experiments revealed that traits differ greatly in importance for species sorting along the gradients. Body growth rate emerged as a key factor distinguishing community types and defining patterns of community stability and coexistence, followed by egg size and maximum body size. Dominance by fast-growing, relatively large, and fecund species occurred more frequently in cases where functional responses were saturated (i.e. high productivity and/or prey accessibility). Such dominance was associated with large biomass fluctuations and priority effects, which prevented richness from increasing with productivity and may have limited selection on secondary traits, such as spawning strategies and relative size at maturation. Our results illustrate that the distribution of species traits and the consequences for community dynamics are intimately linked and strictly dependent on how the benefits and costs of these traits are balanced across different conditions.

  15. Anomaly formulas for the complex-valued analytic torsion on compact bordisms.

    PubMed

    Maldonado Molina, Osmar

    2013-06-01

    We extend the complex-valued analytic torsion, introduced by Burghelea and Haller on closed manifolds, to compact Riemannian bordisms. We do so by considering a flat complex vector bundle over a compact Riemannian manifold, endowed with a fiberwise nondegenerate symmetric bilinear form. The Riemmanian metric and the bilinear form are used to define non-selfadjoint Laplacians acting on vector-valued smooth forms under absolute and relative boundary conditions. In order to define the complex-valued analytic torsion in this situation, we study spectral properties of these generalized Laplacians. Then, as main results, we obtain so-called anomaly formulas for this torsion. Our reasoning takes into account that the coefficients in the heat trace asymptotic expansion associated to the boundary value problem under consideration, are locally computable. The anomaly formulas for the complex-valued Ray-Singer torsion are derived first by using the corresponding ones for the Ray-Singer metric, obtained by Brüning and Ma on manifolds with boundary, and then an argument of analytic continuation. In odd dimensions, our anomaly formulas are in accord with the corresponding results of Su, without requiring the variations of the Riemannian metric and bilinear structures to be supported in the interior of the manifold.

  16. Controllably Alloyed, Low Density, Free-standing Ni-Co and Ni-Graphene Sponges for Electrocatalytic Water Splitting

    NASA Astrophysics Data System (ADS)

    Vineesh, Thazhe Veettil; Mubarak, Suhail; Hahm, Myung Gwan; Prabu, V.; Alwarappan, Subbiah; Narayanan, Tharangattu N.

    2016-08-01

    Synthesis of low cost, durable and efficient electrocatalysts that support oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) are the bottlenecks in water electrolysis. Here we propose a strategy for the development of controllably alloyed, porous, and low density nickel (Ni) and cobalt (Co) based alloys - whose electrocatalytic properties can be tuned to make them multifunctional. Ni and Co based alloy with the chemical structure of Ni1Co2 is identified as an efficient OER catalyst among other stoichiometric structures in terms of over potential @ 10 mAcm‑2 (1.629 V), stability, low tafel slope (87.3 mV/dec), and high Faradaic efficiency (92%), and its OER performance is also found to be on par with the benchmarked IrO2. Tunability in the porous metal synthesis strategy allowed the incorporation of graphene during the Ni sponge formation, and the Ni- incorporated nitrogen doped graphene sponge (Ni-NG) is found to have very high HER activity. A water electrolysis cell fabricated and demonstrated with these freestanding electrodes is found to have high stability (>10 hours) and large current density (10 mAcm‑2 @ 1.6 V), opening new avenues in the design and development of cost effective and light weight energy devices.

  17. PRECISION TIME-DELAY GENERATOR

    DOEpatents

    Carr, B.J.; Peckham, V.D.

    1959-06-16

    A precision time-delay generator circuit with low jitter is described. The first thyratron has a series resonant circuit and a diode which is connected to the second thyratron. The first thyratron is triggered at the begin-ning of a time delay and a capacitor is discharged through the first thyratron and the diode, thereby, triggering the second thyratron. (T.R.H.) l6l9O The instrument described can measure pressures between sea level and 300,000 ft. The pressure- sensing transducer of the instrument is a small cylindrical tube with a thin foil of titanium-tritium fastened around the inside of the tube. Output is a digital signal which can be used for storage or telemetering more conveniently than an analog signal. (W.D.M.) l6l9l An experimental study was made on rolling contacts in the temperature range of 550 to 1000 deg F. Variables such as material composition, hardness, and operating conditions were investigated in a rolling test stand. Ball bearing tests were run to determine the effect of design parameters, bearing materials, lubricants, and operating conditions. (auth)

  18. Tunneling Under Microwave Illumination in Bilayer Two Dimensional Electron Systems

    NASA Astrophysics Data System (ADS)

    Bonetti, J. A.; Pfeiffer, L. N.

    2005-03-01

    The striking Josephson-like effect recently observed [1] in bilayer 2D electron systems at νt=1 raises important questions about the nature of photon-assisted tunneling in this system. For instance, it is unknown whether Shapiro steps will arise, or whether the presence of radiation will lead to photon- assisted sidebands [2]. In order to address these questions, we have examined the effect of microwave radiation on tunneling in bilayer electron systems. Several aspects of coupling radiation into the sample will be presented, including issues of heating and gating. Preliminary results demonstrate a conduction enhancement near gate voltages corresponding to top and bottom layer depletion. The frequency and power dependence of this enhancement will be presented. This work is supported by the NSF and DOE. [1] I.B. Spielman, J.P. Eisenstein, L.N. Pfeiffer, and K.W. West, Phys. Rev. Lett. 84, 5808 (2000). [2]Ady Stern, S. M. Girvin, A. H. MacDonald, and Ning Ma, Phys. Rev. Lett. 86, 1829 (2001)

  19. Observations of meso-scale neutral wind interaction with auroral precipitation in the thermosphere at EISCAT

    NASA Astrophysics Data System (ADS)

    Kosch, Michael; Nozawa, Satonori; Yiu, Ho-Ching Iris; Anderson, Callum; Ogawa, Yasunobu; Howells, Vikki; Baddeley, Lisa; Aruliah, Anasuya; McWhirter, Ian; McCrea, I. W.; Fujii, Ryoichi

    We report on observations of E-region neutral wind fields and their interaction with auroral precipitation at meso-scale spatial resolution. The EISCAT Svalbard radar was used to observe the ionospheric line-of-sight ion flows and temperatures in the E-and F-regions whilst scan-ning its beam. An all-sky optical Scanning Doppler Imager was used at 557.7 nm to observe thermospheric neutral line-of-sight winds and temperatures. High-latitude data from February 2010 are presented. In the case of an auroral arc, strong acceleration of the E-region neutral wind occurs within 10s of km to the arc on a time scale of 10s of minutes. We demonstrate through modelling that this effect cannot be explained by height changes in the 557.7 nm emis-sion layer. The most likely explanation seems to be greatly enhanced ion drag associated with the increased plasma density caused by the particle precipitation, and the localised ionospheric electric field associated with the Pedersen closure current of auroral arcs. Since Joule heat-ing occurs predominantly in the E-region, meso-scale variability in the thermosphere probably accounts for a significant under-estimation in the total energy dissipation.

  20. [Exercise training in heart failure].

    PubMed

    Edelmann, F; Grabs, V; Halle, M

    2014-06-01

    Exercise training in patients with chronic stable heart failure (HF) is a recommended and broadly accepted treatment strategy that is an integral part of an evidence-based management involving pharmacological and non-pharmacological therapies. There is ample scientific evidence that exercise training in HF with reduced (HFrEF) and with preserved ejection fraction (HFpEF) improves exercise capacity, HF symptoms and quality of life. This is due to an improvement of central hemodynamics, endothelial function, neurohumoral activation, skeletal muscle structure and function as well as a decrease in inflammatory markers. The largest randomized, controlled HF-ACTION study (Heart Failure-A Controlled Trial Investigating Outcomes of exercise TraiNing) demonstrated that exercise training results in a modest improvement of all-cause mortality and hospitalizations in HFrEF, depending on adequate compliance. Outcome data in HFpEF are lacking. Besides compliance, efficacy of exercise training is dependent on the intensity and type of exercise. Resistance and high intensity endurance training in addition to a standard aerobic exercise seem to be superior in improving the clinical status of HF patients. In the future, individualized exercise programs will help to improve long-term adherence to exercise training.

  1. Effects of a short-term whole body vibration intervention on lean mass in elderly people.

    PubMed

    Gómez-Cabello, Alba; González-Agüero, Alejandro; Ara, Ignacio; Casajús, José A; Vicente-Rodríguez, Germán

    2013-01-01

    Objetivo: Comprobar si un programa de entrenamiento vibratorio de corta duración tiene algún efecto sobre la masa magra (MM) en personas mayores. Método: 49 personas mayores no institucionalizadas (20 hombres) participaron en el estudio. Los participantes que reunieron los criterios de inclusión fueron distribuidos al azar en el grupo de entrenamiento o el grupo control. Un total de 24 personas entrenaron sobre una plataforma vibratoria 3 veces por semana durante 11 semanas. Mediante absorciometría fotónica dual de rayos X se evaluó la MM del cuerpo completo, brazos y piernas. Se utilizó ANOVA de medidas repetidas para determinar los efectos de la intervención sobre las variables estudiadas y también para determinar los cambios intra-grupo a lo largo del periodo de intervención, incluyendo la edad y altura como variables de confusión. Resultados: 11 semanas de entrenamiento vibratorio no produjeron ningún cambio sobre la MM en ninguna de las regiones. Conclusión: Un programa de entrenamiento vibratorio de corta duración no es suficiente para producir cambios significativos en la masa magra en personas mayores no institucionalizadas.

  2. Effects of eight months of whole body vibration training on hip bone mass in older women.

    PubMed

    Santin-Medeiros, Fernanda; Santos-Lozano, Alejandro; Rey-López, Juan Pablo; Vallejo, Nuria Garatachea

    2015-04-01

    Objetivo: el objetivo de este estudio fue examinar el efecto de 8 meses de entrenamiento vibratorio sobre la masa ósea en mujeres octogenarias. Métodos: 37 mujeres (edad 82.4 [SD=5.7] años) participaron voluntariamente de este estudio. El grupo de intervención (n=19) entrenó sobre la plataforma vibratoria 2 veces por semana (20 Hz and 2 mm), mientras que el grupo control (n=18) no participó de ningún programa de entrenamiento. La masa ósea de la cadera fue medida mediante el absorciometría fotónica dual de rayos X. El test de ANOVA de medidas repetidas fue utilizado para determinar el efecto de la intervención sobre los cambios de masa ósea, así como los cambios intra-grupo a lo largo del período de intervención. Resultados: Después de la intervención, no fueron encontrados cambios estadísticamente significativos en la masa ósea en ninguna de las regiones de la cadera (total de cadera, cuello de femur, trocánter, intertrocanterea, area de Ward). Conclusiones: Nuestra intervención basada en la aplicación exclusiva de entrenamiento vibratorio de cuerpo entero (2 veces a la semana) en mujeres octogenarias no produce efectos osteogénicos en la región de la cadera.

  3. Sports cardiology: lessons from the past and perspectives for the future

    PubMed Central

    Leischik, Roman

    2015-01-01

    The possibility of myocardial damage as a result of endurance sport has been known about since ancient times. According to a leg­end, a soldier named Pheidippides (more likely Philippides) dropped dead after run­ning from war-torn Marathon to Athens with the news of victory. Millennia later, we do not know whether he was a soldier or a courier, or whether he really ran the entire 240 km from Athens to Sparta and then back from Marathon to Athens. What is clear however, is that his death went down in history as the first documented exercise-related death and provides a tangible starting-point for the discipline of sport cardiology. Sports cardiology today covers a broad range of areas; from patients with cardiomyopathies, coronary disease and metabolic syndrome through to fitness fans, high-performance athletes and those with physically demanding professions. The following editorial introduces the primary topics for discussion to be included in the F1000Research channel Sports cardiology with the hope that this will evoke open, controversial and broad discourse in the form of reviews and original research papers in this important field. PMID:26097692

  4. [Experience of off-label use of Eltrombopag in the treatment of thrombocytopenia associated with solid tumors].

    PubMed

    García Lagunar, María Henar; Cerezuela Fuentes, Pablo; Martínez Penella, Mónica; Gutiérrez-Meca Maestre, Dolores Paula; García Coronel, María; Martínez Ortiz, María José

    2015-05-01

    Objetivo: Describir los resultados del uso fuera de indicación de eltrombopag en pacientes con trombocitopenia limitante de tratamiento quimioterápico y tumores sólidos. Método: Estudio observacional retrospectivo en el que se incluyeron todos los pacientes con tumores sólidos tratados con eltrombopag por trombocitopenia durante el tratamiento con quimioterapia entre enero de 2012 y diciembre de 2014. Resultados: Seis pacientes, con tumores sólidos y trombocitopenia limitante de tratamiento, recibieron eltrombopag durante el periodo de estudio con una disminución en el retraso de ciclos de quimioterapia (4,83 ± 4,79 ciclos retrasados antes del inicio de eltrombopag vs 2,50 ± 4,32 ciclos durante el tratamiento con eltrombopag, p=0,492) y un aumento en el porcentaje de dosis real administrada (89,29 ± 13,36% vs 91,43 ± 10,69%, p=0,682). Así mismo, se produjo un aumento en el nadir de plaquetas (55,29 ± 16,45x109/L vs 76,14 ± 36,38x109/L, p=0,248) sin requerir en ningún paciente soporte transfusional con plaquetas durante el tratamiento con eltrombopag. Conclusiones: eltrombopag ha resultado ser una alternativa de tratamiento para pacientes con trombocitopenia limitante de tratamiento con quimioterapia, siendo necesarios ensayos clínicos con mayor número de pacientes que confirmen estos resultados.

  5. Schrödinger

    NASA Astrophysics Data System (ADS)

    Kilmister, C. W.

    1989-03-01

    1. Introduction C. W. Kilmister; 2. Boltzmann's influence on Schrödinger Dieter Flamm; 3. Schrödinger's original interpretation of the Schrödinger equation: a rescue attempt Jon Dorling; 4. Are there quantum jumps? J. S. Bell; 5. Square root of minus one, complex phases and Erwin Schrödinger Chen Ning Yung; 6. Consequences of the Schrödinger equation for atomic and molecular physics W. E. Thirring; 7. Molecular dynamics: from H + H, to biomolecules Martin Karplus; 8. Orbital presentation of chemical reactions Kenichi Fukui; 9. Quantum chemistry A. D. Buckingham; 10. Eamon de Valera, Erwin Schrödinger and the Dublin Institute Sir William McCrea; 11. Do bosons condense? J. T. Lewis; 12. Schrödinger's nonlinear optics James McConnell; 13. Schrödinger's unified field theory seen 40 years later O. Hittmair; 14. The Schrödinger equation of the Universe S. W. Hawking; 15. Overview of particle physics A. Salam; 16. Gauge fields, topological defects and cosmology T. W. B. Kibble; 17. Quantum theory and astronomy M. J. Seaton; 18. Schrödinger's contributions to chemistry and biology Linus Pawling; 19. Erwin Schrödinger's What is Life? and molecular biology M. F. Perutz.

  6. Development and application of a generic CFD toolkit covering the heat flows in combined solid-liquid systems with emphasis on the thermal design of HiLumi superconducting magnets

    NASA Astrophysics Data System (ADS)

    Bozza, Gennaro; Malecha, Ziemowit M.; Van Weelderen, Rob

    2016-12-01

    The main objective of this work is to develop a robust multi-region numerical toolkit for the modeling of heat flows in combined solid-liquid systems. Specifically heat transfer in complex cryogenic system geometries involving super-fluid helium. The incentive originates from the need to support the design of superconductive magnets in the framework of the HiLumi-LHC project (Brüning and Rossi, 2015) [1]. The intent is, instead of solving heat flows in restricted domains, to be able to model a full magnet section in one go including all relevant construction details as accurately as possible. The toolkit was applied to the so-called MQXF quadrupole magnet design. Parametrisation studies were used to find a compromise in thermal design and electro-mechanical construction constraints. The cooling performance is evaluated in terms of temperature margin of the magnets under full steady state heat load conditions and in terms of maximal sustainable load. We also present transient response to pulse heat loads of varying duration and power and the system response to time-varying cold source temperatures.

  7. Controllably Alloyed, Low Density, Free-standing Ni-Co and Ni-Graphene Sponges for Electrocatalytic Water Splitting

    PubMed Central

    Vineesh, Thazhe Veettil; Mubarak, Suhail; Hahm, Myung Gwan; Prabu, V.; Alwarappan, Subbiah; Narayanan, Tharangattu N.

    2016-01-01

    Synthesis of low cost, durable and efficient electrocatalysts that support oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) are the bottlenecks in water electrolysis. Here we propose a strategy for the development of controllably alloyed, porous, and low density nickel (Ni) and cobalt (Co) based alloys - whose electrocatalytic properties can be tuned to make them multifunctional. Ni and Co based alloy with the chemical structure of Ni1Co2 is identified as an efficient OER catalyst among other stoichiometric structures in terms of over potential @ 10 mAcm−2 (1.629 V), stability, low tafel slope (87.3 mV/dec), and high Faradaic efficiency (92%), and its OER performance is also found to be on par with the benchmarked IrO2. Tunability in the porous metal synthesis strategy allowed the incorporation of graphene during the Ni sponge formation, and the Ni- incorporated nitrogen doped graphene sponge (Ni-NG) is found to have very high HER activity. A water electrolysis cell fabricated and demonstrated with these freestanding electrodes is found to have high stability (>10 hours) and large current density (10 mAcm−2 @ 1.6 V), opening new avenues in the design and development of cost effective and light weight energy devices. PMID:27510857

  8. Westinghouse Cementation Facility of Solid Waste Treatment System - 13503

    SciTech Connect

    Jacobs, Torsten; Aign, Joerg

    2013-07-01

    During NPP operation, several waste streams are generated, caused by different technical and physical processes. Besides others, liquid waste represents one of the major types of waste. Depending on national regulation for storage and disposal of radioactive waste, solidification can be one specific requirement. To accommodate the global request for waste treatment systems Westinghouse developed several specific treatment processes for the different types of waste. In the period of 2006 to 2008 Westinghouse awarded several contracts for the design and delivery of waste treatment systems related to the latest CPR-1000 nuclear power plants. One of these contracts contains the delivery of four Cementation Facilities for waste treatment, s.c. 'Follow on Cementations' dedicated to three locations, HongYanHe, NingDe and YangJiang, of new CPR-1000 nuclear power stations in the People's Republic of China. Previously, Westinghouse delivered a similar cementation facility to the CPR-1000 plant LingAo II, in Daya Bay, PR China. This plant already passed the hot functioning tests successfully in June 2012 and is now ready and released for regular operation. The 'Follow on plants' are designed to package three 'typical' kind of radioactive waste: evaporator concentrates, spent resins and filter cartridges. The purpose of this paper is to provide an overview on the Westinghouse experience to design and execution of cementation facilities. (authors)

  9. Sports cardiology: lessons from the past and perspectives for the future.

    PubMed

    Leischik, Roman

    2015-01-01

    The possibility of myocardial damage as a result of endurance sport has been known about since ancient times. According to a leg-end, a soldier named Pheidippides (more likely Philippides) dropped dead after run-ning from war-torn Marathon to Athens with the news of victory. Millennia later, we do not know whether he was a soldier or a courier, or whether he really ran the entire 240 km from Athens to Sparta and then back from Marathon to Athens. What is clear however, is that his death went down in history as the first documented exercise-related death and provides a tangible starting-point for the discipline of sport cardiology. Sports cardiology today covers a broad range of areas; from patients with cardiomyopathies, coronary disease and metabolic syndrome through to fitness fans, high-performance athletes and those with physically demanding professions. The following editorial introduces the primary topics for discussion to be included in the F1000Research channel Sports cardiology with the hope that this will evoke open, controversial and broad discourse in the form of reviews and original research papers in this important field.

  10. Physical activity and cardiorespiratory fitness in adolescents with Down syndrome.

    PubMed

    Matute-Llorente, A; González-Agüero, A; Gómez-Cabello, A; Vicente-Rodríguez, G; Casajús, J A

    2013-01-01

    Objetivos: Comprobar si los adolescentes con síndrome de Down (SD) cumplen las guías de actividad física (AF) y evaluar la relación entre AF y la condición cardiorrespiratoria. Métodos: 42 adolescentes (27 con SD) participaron en este estudio. La AF se midió usando acelerometría. La condición cardiorrespiratoria se evaluó mediante ergoespirometría en tapiz rodante con un protocolo progresivo continuo. Resultados: Los adolescentes con SD pasaron menos tiempo en AF sedentaria, moderada (MAF), vigorosa (VAF) y moderada-vigorosa (MVAF) que los adolescentes sin SD. El VO2peak mostró correlación con minutos totales en AF ligera, MAF, VAF y MVAF en el grupo control (desde r = 0,55 hasta r = 0,61, p < 0,05) y con MAF y VAF en el grupo de adolescentes con SD (desde r = 0,38 hasta r = 0,41, p < 0,05). Conclusión: Ningún grupo alcanzó 60 minutos de MAF diaria. La capacidad cardiorrespiratoria en adolescentes con SD se asoció con una mayor participación en MAF.

  11. The Hubble law as a kinematic outcome of the space-time conformal geometry

    SciTech Connect

    Tomilchik, L. M.

    2010-03-24

    The description of the cosmological expansion and its possible local manifestations as a pure kinematic effects of the space-time conformal geometry is given. The explicit form of the conformal deformation of time is established. The expression de pound ning the cosmological distance in the form of simple function on the red shift is obtained. By coupling it with the relativistic formula for the longitudinal Doppler effect, the explicit analytic expression for the Hubble law is obtained. The expression generalizing the standard Hubble law reproduces the experimentally observed phenomenon treated conventionally as a Dark Energy manifestation. The expression for conformal time deformation in the small time limit leads to the quadratic time nonlinearity. Being applied to describe the location-type experiments, this predicts the existence of the universal uniformly changing blue-shifted frequency drift. Phenomenon of the Pioneer Anomaly (PA) is treated as the pound rst of such a kind of effects discovered experimentally. The obtained formulae reproduce the Pioneer Anomaly experimental data.

  12. Fistules carotido-caverneuses post-traumatiques à propos d'un cas et revue de la littérature

    PubMed Central

    Oumellal, Jamal; Bekaert, Olivier; Gallas, Sophie; Leguerinel, Caroline; Palfi, Stéphane; Derkaoui, Fahd; Fatemi, Nizar El; Gana, Rachid; Elmaquili, Moulay Rachid; Elabbadi, Najia

    2015-01-01

    Les auteurs rapportent une observation clinique d'une fistule carotidocaverneuse survenue à la suite d'un traumatisme craniofaciale grave. Une exophtalmie unilatérale pulsatile et asymétrie des 2 sinus caverneux au scanner ont permis de suspecter le diagnostic. Une artériographie a permis de confirmer ce diagnostic, avec embolisation couronnée de succès chez ce malade, mais l’évolution est défavorable sur le plan neurologique avec apparition d'une HTIC réfractaire au traitement médical maximal. La fistule carotido-caverneuse est une complication rare mais grave pouvant engager le pronostic fonctionnel (cécité) et vital (hémorragie méningée et intracérébrale).L'artériographie et l'embolisation en un seul temps ont considérablement amélioré le pronostic. PMID:26587139

  13. Sulphur Extraction at Bryan Mound

    SciTech Connect

    Kirby, Carolyn L; Lord, Anna C. Snider

    2015-08-01

    The Bryan Mound caprock was subjected to extens ive sulphur mining prior to the development of the Strategic Petroleum Reserve. Undoubtedl y, the mining has modified the caprock integrity. Cavern wells at Bryan Mound have been subject to a host of well integr ity concerns with many likely compromised by the cavernous capro ck, surrounding corrosive environment (H 2 SO 4 ), and associated elevated residual temperatures al l of which are a product of the mining activities. The intent of this study was to understand the sulphur mining process and how the mining has affected the stability of the caprock and how the compromised caprock has influenced the integrity of the cavern wells. After an extensiv e search to collect pert inent information through state agencies, literature sear ches, and the Sandia SPR librar y, a better understanding of the caprock can be inferred from the knowledge gaine d. Specifically, the discovery of the original ore reserve map goes a long way towards modeling caprock stability. In addition the gained knowledge of sulphur mining - subs idence, superheated corrosive wa ters, and caprock collapse - helps to better predict the post mi ning effects on wellbore integrity. This page intentionally left blank

  14. TARANIS : a Project of Microsatellite for the Study of Sprites and Associated Emissions

    NASA Astrophysics Data System (ADS)

    Blanc, E.; Lefeuvre, F.

    2004-12-01

    Taranis (Tool for the Analysis of RAdiations from lightNIngs and Sprites) is a CNES microsatellite project which will be in phase A in 2005. It proposes to measure sprites, halos, jets and elves and the associated terrestrial and X ray flashes, electromagnetic and electrostatic emissions, and energetic electrons at the nadir above thunderstorm. These complementary measurements will be carried on a local and global scale in order to understand the physical mechanisms responsible for the impulsive transfers of energy between the neutral atmosphere and plasmas of the ionosphere and magnetosphere. The purpose is to study the coupling between the low and middle atmosphere, the thermosphere, the ionosphere and the magnetosphere. The final goal is to establish the impact of these processes on the Earth's environment. The purpose of the presentation is to describe the project, its scientific objectives, the mission, the scientific payload. The sprite observation method at the nadir by spectral differentiation is already used by the experiment LSO (Lightning and Sprite Observations) on board of the International Space Station.

  15. LabData database sub-systems for post-processing and quality control of stable isotope and gas chromatography measurements

    NASA Astrophysics Data System (ADS)

    Suckow, A. O.

    2013-12-01

    Measurements need post-processing to obtain results that are comparable between laboratories. Raw data may need to be corrected for blank, memory, drift (change of reference values with time), linearity (dependence of reference on signal height) and normalized to international reference materials. Post-processing parameters need to be stored for traceability of results. State of the art stable isotope correction schemes are available based on MS Excel (Geldern and Barth, 2012; Gröning, 2011) or MS Access (Coplen, 1998). These are specialized to stable isotope measurements only, often only to the post-processing of a special run. Embedding of algorithms into a multipurpose database system was missing. This is necessary to combine results of different tracers (3H, 3He, 2H, 18O, CFCs, SF6...) or geochronological tools (Sediment dating e.g. with 210Pb, 137Cs), to relate to attribute data (submitter, batch, project, geographical origin, depth in core, well information etc.) and for further interpretation tools (e.g. lumped parameter modelling). Database sub-systems to the LabData laboratory management system (Suckow and Dumke, 2001) are presented for stable isotopes and for gas chromatographic CFC and SF6 measurements. The sub-system for stable isotopes allows the following post-processing: 1. automated import from measurement software (Isodat, Picarro, LGR), 2. correction for sample-to sample memory, linearity, drift, and renormalization of the raw data. The sub-system for gas chromatography covers: 1. storage of all raw data 2. storage of peak integration parameters 3. correction for blank, efficiency and linearity The user interface allows interactive and graphical control of the post-processing and all corrections by export to and plot in MS Excel and is a valuable tool for quality control. The sub-databases are integrated into LabData, a multi-user client server architecture using MS SQL server as back-end and an MS Access front-end and installed in four

  16. PubMed

    Izaola, Olatz; De la Fuente, Beatriz; Gómez Hoyos, Emilia; López Gómez, Juan José; Torres, Beatriz; Ortola, Ana; De Luis, Daniel A

    2017-02-01

    Objetivo: el objetivo de nuestro trabajo fue evaluar la tolerancia de una fórmula enteral con alta densidad energetica en pacientes hospitalizados en una unidad de coronarias con indicación de soporte enteral al menos durante cinco días.Métodos: estudio abierto, no comparativo, no aleatorizado, descriptivo, para evaluar la tolerancia de una fórmula enteral con alta densidad energética en pacientes ingresados en una unidad coronaria.Resultados: se incluyeron 31 pacientes con una media de edad de 67,32 ± 13,8 años y de los cuales el 66,7% eran varones. El volumen medio final prescrito de Nutrison Energy®fue de 928,5 ± 278,5 ml/día (rango: 800-1.500 ml/día). La duración media de la nutrición enteral fue de 11,2 ± 3,2 días. El aporte final promedio de calorías fue de 1.392 ± 417 cal/día, con 169,9 ± 50,9 g/día de hidratos de carbono, 53,8 ± 16,1 g/día de grasas y 55,7 ± 16,9 g/día de proteínas. Tras la administ racion existió un aumento significativo de los niveles de transferrina. Un total de 3 pacientes habían presentado algún episodio de diarrea (9,7%). El número de pacientes que presentaron al menos un episodio de residuo gástrico fue de 5 (16,1%) que no obligo en ningún caso a la suspensión de la nutrición enteral, obligando en 2 pacientes a disminuir el volumen del aporte nutricional durante 24 horas. Durante el soporte nutricional, solo en 3 pacientes fue necesario disminuir el volumen aportado el día previo de la fórmula energética. Con respecto a los vómitos, solo en 1 paciente se constató esta situación (3,2%). Ningún paciente presentó en el estudio otras complicaciones digestivas asociadas a la administración de la fórmula de nutrición enteral. Por último, no se registraron acontecimientos adversos relacionados con la fórmula administrada.Conclusiones: los resultados reflejan que una fórmula enteral con alta densidad energética es una fórmula bien tolerada con una muy baja frecuencia de s

  17. Double Mantle Plume Upwelling—A Possible Formation Mechanism of Beta Plateau and Devana Chasma,Venus

    NASA Astrophysics Data System (ADS)

    Ding, N.

    2009-12-01

    Ning Ding,Zuoxun Zeng,China University of Geosciences,Wuhan,430074,China NingDing.eagle@gmail.com Introduction:Venus represents a‘one plate planet’[1],and the uplift,fractures and volcanism in Beta Regio on Venus are considered to be formed by lithosphere uplift driven by a hot plume[2]. Based on the double peaking saddle landform,we suggest the tectonic pattern of double mantle plume upwelling to interpret the formation mechanism of Beta Plateau and Devana Chasma.We take a physical modeling to validate this possibility. Model:There is no ductile shear in Venus[3],so we use quartz sands to simulate the crust of Venus.We use two wood stickes 1.5cm in diameter rising from the rubber canvas slowly and straight till about half of the model,then falling down slowly and straight.The base is a hard rubber plate,in the center of which,there are two holes 3cm in diameter,and the distance between them is 5cm.The holes are covered by rubber canvas.We use the quartz sands in colours of white, red and black with particle size of 70 mess as the model materials. Result:Fig.1:At the beginning of the wood stickes upwelling,only fine radial cracks are formed above the upwelling from central to outside.With the upwelling continue,surface energy of the fine radial cracks increase and make the cracks unstable,finally,the fine radial cracks connect each other and form a fracture zone.And then the two mantle plume downwelling,the fracture zone is developed to form a chasma at the end. Fig.2:The four profiles all form reverse faults outside and normal faults inside.But the difference is the faults in the middle of the chasma goes deeper than others.It is the pattern of Beta Plateau where the tectonic rising is cut by Devana Chasma zone in the topographic features. Fig.3:From the tow fig., we can see two points similar:a.the elevation is high and distribution area is large around the area of two upwelling and it is high around the area of chasma,but the distribution area is small

  18. Evolution of a Subduction Zone

    NASA Astrophysics Data System (ADS)

    Noack, Lena; Van Hoolst, Tim; Dehant, Veronique

    2014-05-01

    the subduction of the oceanic crust in terms of subduction velocity and subduction angle over time. We develop scaling laws combining the subduction velocity and angle depending on the mantle environment (and thus time). These laws can then be applied to continental growth simulations with 1D parameterized models (Höning et al., in press) or 2D/3D subduction zone simulations at specific geological times (using the correct subduction zone setting). References: Quinquis, M. et al. (in preparation). A comparison of thermo-mechanical subduction models. In preparation for G3. Noack, L., Van Hoolst, T., Dehant, V., and Breuer, D. (2013). Relevance of continents for habitability and self-consistent formation of continents on early Earth. XIII International Workshop on Modelling of Mantle and Lithosphere Dynamics, Hønefoss, Norway, 31. Aug. - 5. Sept. 2013. Höning, D., Hansen-Goos, H., Airo, A., and Spohn, T. (in press). Biotic vs. abiotic Earth: A model for mantle hydration and continental coverage. Planetary and Space Science.

  19. Numerical Simulation of Floating Bodies in Extreme Free Surface Waves

    NASA Astrophysics Data System (ADS)

    Hu, Zheng Zheng; Causon, Derek; Mingham, Clive; Qiang, Ling

    2010-05-01

    A task of the EPSRC funded research project 'Extreme Wave loading on Offshore Wave Energy Devices: a Hierarchical Team Approach' is to investigate the survivability of two wave energy converter (WEC) devices Pelamis and the Manchester Bobber using different CFD approaches. Both devices float on the water surface, generating the electricity from the motion of the waves. In this paper, we describe developments of the AMAZON-SC 3D numerical wave tank (NWT) to study extreme wave loading of a fixed or floating (in Heave motion) structure. The extreme wave formulation as an inlet condition is due to Dalzell (1999) and Ning et. al. (2009) in which a first or second-order Stokes focused wave can be prescribed. The AMAZON-SC 3D code (see e.g. Hu et al. (2009)) uses a cell centred finite volume method of the Godunov-type for the space discretization of the Euler and Navier Stokes equations. The computational domain includes both air and water regions with the air/water boundary captured as a discontinuity in the density field thereby admitting the break up and recombination of the free surface. Temporal discretisation uses the artificial compressibility method and a dual time stepping strategy to maintain a divergence free velocity field. Cartesian cut cells are used to provide a fully boundary-fitted gridding capability on an regular background Cartesian grid. Solid objects are cut out of the background mesh leaving a set of irregularly shaped cells fitted to the boundary. The advantages of the cut cell approach have been outlined previously by Causon et al. (2000, 2001) including its flexibility for dealing with complex geometries whether stationary or in relative motion. The field grid does not need to be recomputed globally or even locally for moving body cases; all that is necessary is to update the local cut cell data at the body contour for as long as the motion continues. The handing of numerical wave paddles and device motion in a NWT is therefore straightforward

  20. [Intestinal dysbiosis in pediatric patients with Crohn's disease].

    PubMed

    Pueyo, Blanca; Mach, Núria

    2013-11-01

    Introducción La enfermedad de Crohn (EC) pediátrica es un desorden caracterizado por presentar inflamación crónica que puede afectar cualquier segmento del tracto gastrointestinal. La disbiosis intestinal es un factor implicado en la patogénesis multifactorial de esta enfermedad. Diferentes suplementos dietarios se han propuesto como terapia alternativa para inducir o mantener la remisión de la EC. Objetivo Revisar las evidencias científicas publicadas sobre disbiosis intestinal en pacientes de Crohn pediátricos y la eficacia de la terapia con suplementos dietarios (especialmente probióticos). Material y métodos Se ha realizado una extensa búsqueda de publicaciones científicas en las principales bases de datos electrónicas especializadas: NCBI, Elsevier, Scielo, Scirus y Science Direct. Resultados y Discusión Se ha observado en la población pediátrica de EC un aumento de Proteobacteria y una reducción de Firmicutes. Los resultados referentes a los phyla Bacteroidetes y Actinobacteria son divergentes. Referente al uso de suplementos dietarios, el uso de probióticos no ha mostrado ningún impacto positivo en la EC pediátrica. Conclusiones Los resultados publicados hasta la fecha referentes a la disbiosis intestinal en pacientes pediátricos de Crohn, contribuyen al mejor conocimiento y entendimiento de las modificaciones en la flora bacteriana. Sin embargo, no es posible definir una microbiota asociada o causante de la EC. Además, los resultados publicados hasta la fecha no aportan evidencias sólidas de la eficacia de los probióticos como terapia en dichos pacientes.

  1. The Onsala Twin Telescope Project

    NASA Astrophysics Data System (ADS)

    Haas, R.

    2013-08-01

    This paper described the Onsala Twin Telescope project. The project aims at the construction of two new radio telescopes at the Onsala Space Observatory, following the VLBI2010 concept. The project starts in 2013 and is expected to be finalized within 4 years. Z% O. Rydbeck. Chalmers Tekniska Högskola, Göteborg, ISBN 91-7032-621-5, 407-823, 1991. B. Petrachenko, A. Niell, D. Behrend, B. Corey, J. Böhm, P. Charlot, A. Collioud, J. Gipson, R. Haas, Th. Hobiger, Y. Koyama, D. MacMillan, Z. Malkin, T. Nilsson, A. Pany, G. Tuccari, A. Whitney, and J. Wresnik. Design Aspects of the VLBI2010 System. NASA/TM-2009-214180, 58 pp., 2009. R. Haas, G. Elgered, J. Löfgren, T. Ning, and H.-G. Scherneck. Onsala Space Observatory - IVS Network Station. In K. D. Baver and D. Behrend, editors, International VLBI Service for Geodesy and Astrometry 2011 Annual Report, NASA/TP-2012-217505, 88-91, 2012. H.-G. Scherneck, G. Elgered, J. M. Johansson, and B. O. Rönnäng. Phys. Chem. Earth, Vol. 23, No. 7-8, 811-823, 1998. A. R. Whitney. Ph.D. thesis, Dept. of Electrical engineering, MIT Cambridge, MA., 1974. B. A. Harper, J. D. Kepert, and J. D. Ginger. Guidelines for converting between various wind averaging periods in tropical cyclone conditions. WMO/TD-No. 1555, 64 pp., 2010 (available at \\url{http://www.wmo.int/pages/prog/www/tcp/documents/WMO_TD_1555_en.pdf})

  2. [Locally administered ropivacaine vs. standard analgesia for laparoscopic cholecystectomy].

    PubMed

    Chavarría-Pérez, Teresa; Cabrera-Leal, Carlos Fernando; Ramírez-Vargas, Susana; Reynada, José Luis; Arce-Salinas, César Alejandro

    2015-01-01

    Introducción: se desconoce qué modalidad analgésica brinda mejores resultados después de una colecistectomía laparoscópica. El objetivo de este estudio consistió en valuar la eficacia analgésica de la ropivacaína usada localmente contra la dipirona por vía intravenosa en colecistectomía laparoscópica. Métodos: ensayo clínico al azar, de no inferioridad, en 50 pacientes con colecistectomía laparoscópica para comparar el uso de ropivacaína al 0.75 % infiltrada en el lugar de inserción de los trócares y en la fosa vesicular frente a dipirona por vía intravenosa. El desenlace primario fue dolor evaluado mediante escala visual análoga (EVA) en las primeras 24 horas. Resultados: el promedio de las EVA de dolor al término de la cirugía fue de 3.8 frente a 3.56 en el grupo de ropivacaína o de dipirona, mientras que a las 6, 12 y 24 horas fueron 2.64 frente a 2.6, 1.92 frente a 1.88 y 1.28 frente a 1.2, respectivamente. No hubo efectos adversos en ningún grupo y la necesidad de rescates analgésicos con tramadol fue similar entre ambos grupos. Conclusiones: la ropivacaína al 0.75 % infiltrada en el lugar de inserción de los trócares y la fosa vesicular muestra una analgesia similar a la dipirona por vía intravenosa en las primeras 24 horas después de una colecistectomía laparoscópica, sin efectos adversos.

  3. PubMed

    Valenzuela Mencía, Javier; Fernández Castillo, Rafael; Martos Cabrera, María Begoña; Gómez-Urquiza, José Luis; Albendín García, Luis; Cañadas de la Fuente, Guillermo Arturo

    2017-02-01

    Introducción: usualmente se ha recomendado a personas diabéticas seguir una dieta baja en grasas. Sin embargo, las dietas bajas en carbohidratos (DBCH) parecen ser, al menos, igual de efectivas que las bajas en grasas, incluso aportan mejores resultados en algunos casos en cuanto a control glicémico, disminución de peso corporal y mejora de marcadores de riesgo cardiovascular.Objetivos: analizar el efecto de las DBCH con respecto a dietas bajas en grasas (DBG) u otras, en cuanto a glucemia basal, hemoglobina glicosilada (HbA1c), peso corporal, colesterol total y triglicéridos.Métodos:búsqueda bibliográfica de estudios publicados en Medline, Scopus, Cinahl, Lilacs, Dialnet, Scielo y ProQuest. Se extrajeron datos sobre la composición de las dietas evaluadas, duración y cambios respecto a glucemia basal, HbA1c, peso corporal, colesterol y triglicéridos.Resultados: se incluyen 15 estudios en la revisión: en uno de ellos se encontraron diferencias significativas entre grupos en los niveles de glucemia basal, en 6 en cuanto a HbA1c y en 3 en cuanto a peso corporal. Con respecto a los niveles de lípidos sanguíneos, no se encuentran en ningún estudio diferencias significativas entre grupos en cuanto al colesterol total, mientras que sí se encuentran en 3 estudios respecto a los niveles de triglicéridos.Conclusiones: esta revisión muestra que las DBCH pueden ser efectivas en algunos aspectos como la reducción de HbA1c, de peso corporal o de triglicéridos, aunque no hay suficiente evidencia científica que respalde su uso a largo plazo por encima de otras dietas, por lo que se precisa de más investigaciones futuras.

  4. Isolation and Genetic Characterization of Mangshi Virus: A Newly Discovered Seadornavirus of the Reoviridae Family Found in Yunnan Province, China

    PubMed Central

    Wang, Jinglin; Li, Huachun; He, Yuwen; Zhou, Yang; Meng, Jingxing; Zhu, Wuyang; Chen, Hongyu; Liao, Defang; Man, Yunping

    2015-01-01

    Background Seadornavirus is a genus of viruses in the family Reoviridae, which consists of Banna virus, Kadipiro virus, and Liao ning virus. Banna virus is considered a potential pathogen for zoonotic diseases. Here, we describe a newly discovered Seadornavirus isolated from mosquitos (Culex tritaeniorhynchus) in Yunnan Province, China, which is related to Banna virus, and referred to as Mangshi virus. Methods and Results The Mangshi virus was isolated by cell culture in Aedes albopictus C6/36 cells, in which it replicated and caused cytopathic effects, but not in mammalian BHK-21 or Vero cells. Polyacrylamide gel analysis revealed a genome consisting of 12 segments of double-stranded RNA, with a “6–4–2” pattern in which the migrating bands were different from those of the Banna virus. Complete genome sequencing was performed by full-length amplification of cDNAs. Sequence analysis showed that seven highly conserved nucleotides and three highly conserved nucleotides were present at the ends of the 5′- and 3′-UTRs in each of 12 genome segments. The amino acid identities of Mangshi virus shared with Balaton virus varied from 27.3% (VP11) to 72.3% (VP1) with Banna virus varying from 18.0% (VP11) to 63.9% (VP1). Phylogenetic analysis based on amino acid sequences demonstrated that Mangshi virus is a member of the genus Seadornavirus and is most closely related to, but distinct from, Balaton virus and Banna virus in the genus Seadornavirus of the family Reoviridae. Conclusion Mangshi virus isolated from mosquitoes (C. tritaeniorhynchus) was identified as a newly discovered virus in the genus Seadornavirus and is phylogenetically close to Banna virus, suggesting that there is genetic diversity of seadornaviruses in tropical and subtropical areas of Southeast Asia. PMID:26630378

  5. Anthropogenic Pb input into Bohai Bay, China: Evidence from stable Pb isotopic compositions in sediments

    NASA Astrophysics Data System (ADS)

    Hu, Ningjing; Huang, Peng

    2016-04-01

    Anthropogenic Pb input into Bohai Bay, China: Evidence from stable Pb isotopic compositions in sediments Hu Ning-jinga, Huang Pengb,, Liu Ji-huaa, a First Institute of Oceanography, State Oceanic Administration, Qingdao 266061, China b Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China To investigate the source of Pb within Bohai Bay, Pb concentrations and Pb isotopic compositions (204Pb, 206Pb, 207Pb, and 208Pb) of surface sediments in this area were determined. The Pb concentration in this bay varied widely from 6.9 to 39.2 μg/g (average: 21.8 ± 7.8 μg/g), and the Pb isotopic compositions ranged from 0.8338 to 0.8864 (average: 2.0997 ± 0.0180) for 208Pb/206Pb and from 2.0797 to 2.1531 (average: 0.8477 ± 0.0135) for 207Pb/206Pb, presenting in three distinct clusters. The Pb isotopic ratios of sediments from the northeastern (NE zone) and northwestern (NW zone) coastal areas were significantly influenced by anthropogenic sources such as coal combustion and automobile emission. In sediments from the central and southern Bohai Bay (C-S zone); however, Pb mainly originated from the Yellow River catchment, as a result of lithogenic sediment (from rock weathering) accumulation. The Pb isotopic ratios further indicate that, apart from riverine inputs, the neighboring large-scale ports and aerosols significantly contributed to the anthropogenic Pb contained in these sediments. Pb contamination in the Haihe and Luanhe river mouths as well as in the regions near ports is also suggested from anthropogenic enrichment factors. As cities and ports continue to develop around Bohai Bay, a long-term extensive sewage monitoring program is highly recommended.

  6. Tétanos compliqué de septicémie sur hémoglobinopathie majeure

    PubMed Central

    Mamoudou, Savadogo; François, Lionnet; Canestri, Ana; Bellaud, Guillaume

    2014-01-01

    Rapporter un cas de tétanos compliqué de septicémie chez un enfant souffrant d'une hémoglobinopathie majeure. Enfant de 9 ans drépanocytaire (SC), non vacciné contre le tétanos, a été admis au CHU YO pour raideur de la nuque, difficulté à l'ouverture de la bouche et hyperthermie. L'examen à son admission notait un syndrome infectieux avec une hyperthermie (température à 39°1C), Pouls = 100/mn, Fréquence cardiaque = 100batt/mn, fréquence respiratoire = 30cycles/mn, poids =22Kg, un trismus, une contracture des muscles para vertébraux, des paroxysmes toniques à la palpation (stade II de Mollaret), un syndrome méningé. L'examen n'avait pas retrouvé une porte d'entrée. La ponction lombaire avait ramené un liquide céphalo rachidien clair; l'hémogramme avait montré une hyperleucocytose à 10 200/mm3, et l'hémoculture a permis d'isoler Staphylococcus aureus. Sous antibiothérapie et sous sédatifs, l’évolution a été favorable. Les porteurs d'hémoglobinopathie majeure sont plus exposés aux infections. La physiopathologie de ces infections s'explique par l'immunodépression et les troubles de la phagocytose. Un dépistage précoce de ces hémoglobinopathies, un bon suivi et une bonne couverture vaccinale des enfants drépanocytaires sont essentiels pour prévenir le tétanos et ses complications. PMID:25995786

  7. Planning and Analysis of Fractured Rock Injection Tests in the Cerro Brillador Underground Laboratory, Northern Chile

    NASA Astrophysics Data System (ADS)

    Fairley, J. P., Jr.; Oyarzún L, R.; Villegas, G.

    2015-12-01

    Early theories of fluid migration in unsaturated fractured rock hypothesized that matrix suction would dominate flow up to the point of matrix saturation. However, experiments in underground laboratories such as the ESF (Yucca Mountain, NV) have demonstrated that liquid water can migrate significant distances through fractures in an unsaturated porous medium, suggesting limited interaction between fractures and unsaturated matrix blocks and potentially rapid transmission of recharge to the sat- urated zone. Determining the conditions under which this rapid recharge may take place is an important factor in understanding deep percolation processes in arid areas with thick unsaturated zones. As part of an on-going, Fondecyt-funded project (award 11150587) to study mountain block hydrological processes in arid regions, we are plan- ning a series of in-situ fracture flow injection tests in the Cerro Brillador/Mina Escuela, an underground laboratory and teaching facility belonging to the Universidad la Serena, Chile. Planning for the tests is based on an analytical model and curve-matching method, originally developed to evaluate data from injection tests at Yucca Mountain (Fairley, J.P., 2010, WRR 46:W08542), that uses a known rate of liquid injection to a fracture (for example, from a packed-off section of borehole) and the observed rate of seepage discharging from the fracture to estimate effective fracture aperture, matrix sorptivity, fracture/matrix flow partitioning, and the wetted fracture/matrix interac- tion area between the injection and recovery points. We briefly review the analytical approach and its application to test planning and analysis, and describe the proposed tests and their goals.

  8. The plasma membrane H+-ATPase is related to the development of salicylic acid-induced thermotolerance in pea leaves.

    PubMed

    Liu, Yanyan; Liu, Hongtao; Pan, Qiuhong; Yang, Haoru; Zhan, Jicheng; Huang, Weidong

    2009-04-01

    The plasma membrane H(+)-ATPase (PM H(+)-ATPase, EC.3.6.1.35) plays a key role in the plant response to environmental stress. In this study, a possible mechanistic link between the PM H(+)-ATPase and salicylic acid (SA)-induced thermotolerance was investigated in pea (Pisum sativum L. cv. NingXia) leaves. The burst of free SA in response to heat acclimation (38 +/- 0.5 degrees C) was observed, and peaks appeared subsequently both in activity and amount of PM H(+)-ATPase in pea leaves during heat acclimation. Similarly, exogenous SA also triggered the two peaks in the room temperature (25 +/- 0.5 degrees C). Paclobutrazol (PAC) was employed to infiltrate onto pea leaves prior to heat acclimation treatment. The results showed that the peaks of both free SA and activity of PM H(+)-ATPase still occurred after the PAC pretreatment. In acquired thermotolerance assessment (malondialdehyde content and degree of wilting), spraying SA and fusicoccin (FC, the activator of PM H(+)-ATPase) separately could protect pea leaves from heat injury. Results from RT-PCR and western blotting analysis indicated that the increase in activity of the PM H(+)-ATPase was due to its transcriptional and translational regulation. The subcellular localizations of PM H(+)-ATPase after the FC or SA pretreatment also showed that the PM H(+)-ATPase is important to maintain the integrity of plasma membrane against the heat stress. Taken together, these results suggest PM H(+)-ATPase is related to the development of SA-induced thermotolerance in pea leaves.

  9. [Guideline for the assessment of clinical research proposals. Comisión Nacional de Investigación Científica del Instituto Mexicano del Seguro Social].

    PubMed

    Mejía-Aranguré, Juan Manuel; Grijalva-Otero, Israel; Majluf-Cruz, Abraham; Cruz-López, Miguel; Núñez-Enríquez, Juan Carlos; Salamanca-Gómez, Fabio Abdiel

    2013-01-01

    Antecedentes: la investigación médica es una herramienta fundamental para lograr el avance de la ciencia al mejorar las acciones encaminadas a proteger, promover y restaurar la salud del individuo y de la sociedad en general. Las tres características imprescindibles para que un protocolo de investigación sea autorizado son: relevancia científica, calidad técnica y el cumplimiento de los aspectos éticos. Material y métodos: estudio retrospectivo efectuado con base en la búsqueda específica en Pubmed, Medline, Ovid y Google Scholar con los términos: peer review, research proposals, review and protocols and reviewers. Debido a que no se identificó ningún artículo que refiriera específicamente los criterios para evaluar protocolos de investigación clínica, se hizo un consenso entre los vocales de la Comisión Nacional de Investigación Científica del Instituto Mexicano del Seguro Social, que está integrada por investigadores titulares de la institución, todos pertenecientes al Sistema Nacional de Investigadores. Se discutieron los criterios que debieran componer una revisión adecuada y cuáles debieran ser los rubros que deben incluirse en el análisis. Resultados: se integraron los criterios específicos que le permitirán al revisor de un protocolo de investigación realizar una crítica con bases metodológicas aceptadas por un consenso de investigadores. Conclusiones: un revisor debe ser considerado como un promotor del avance del conocimiento científico que, mediante sus comentarios y su dictamen, permite que los investigadores incrementen la calidad de sus protocolos de investigación.

  10. Neutron Monitor Observations and Space Weather, 1. Automatically Search of Great Solar Energetic Particle Event Beginning.

    NASA Astrophysics Data System (ADS)

    Dorman, L. I.; Pustil'Nik, L. A.; Sternlieb, A.; Zukerman, I. G.

    It is well known that in periods of great SEP fluxes of energetic particles can be so big that memory of computers and other electronics in space may be destroyed, satellites and spacecrafts became dead: according to NOAA Space Weather Scales are danger- ous Solar Radiation Storms S5-extreme (flux level of particles with energy > 10 MeV more than 10^5), S4-severe (flux more than 10^4) and S3-strong (flux more than 10^3). In these periods is necessary to switch off some part of electronics for few hours to protect computer memories. These periods are also dangerous for astronauts on space- ships, and passengers and crew in commercial jets (especially during S5 storms). The problem is how to forecast exactly these dangerous phenomena. We show that exact forecast can be made by using high-energy particles (few GeV/nucleon and higher) which transportation from the Sun is characterized by much bigger diffusion coeffi- cient than for small and middle energy particles. Therefore high energy particles came from the Sun much more early (8-20 minutes after acceleration and escaping into so- lar wind) than main part of smaller energy particles caused dangerous situation for electronics (about 30-60 minutes later). We describe here principles and experience of automatically working of program "FEP-Search". The positive result which shows the exact beginning of FEP event on the Emilio Segre' Observatory (2025 m above sea level, Rc=10.8 GV), is determined now automatically by simultaneously increas- ing on 2.5 St. Dev. in two sections of neutron supermonitor. The next 1-min data the program "FEP-Search" uses for checking that the observed increase reflects the begin- ning of real great FEP or not. If yes, automatically starts to work on line the programs "FEP-Research".

  11. Sinomenine potentiates degranulation of RBL-2H3 basophils via up-regulation of phospholipase A2 phosphorylation by Annexin A1 cleavage and ERK phosphorylation without influencing on calcium mobilization.

    PubMed

    Huang, Lufen; Li, Ting; Zhou, Hua; Qiu, Ping; Wu, Jianlin; Liu, Liang

    2015-10-01

    Sinomenine (SIN), an alkaloid derived from the Chinese medicinal plant Sinomenium acutum, is the major component of Zhengqing Fongtong Ning (ZQFTN), a pharmaceutical drug produced by Hunan Zhengqing Pharmaceutical Co. Ltd. in China for the treatment of rheumatoid arthritis and other autoimmune diseases. Some clinic reports indicate that ZQFTN may induce an anaphylactic reaction via potentiating the degranulation of immune cells. In the current study, we aimed to examine whether SIN is capable of inducing the degranulation of basophilic leukemia 2H3 (RBL-2H3) cells to elucidate how the anaphylactic reaction occurs. The results revealed that SIN could up-regulate β-hexosaminidase levels in RBL-2H3 cells without significant cytotoxicity, suggesting that SIN could induce the degranulation of RBL-2H3 cells. Furthermore, SIN increased the release of prostaglandin D2 (PGD2) and prostaglandin E2 (PGE2) in RBL-2H3 cells via promoting the expression of phosphorylated-extracellular signal-regulated kinase (P-ERK), the cleavage of Annexin A1 (ANXA1), and phosphorylated-cytosolic phospholipase A2 (P-cPLA2), as well as cyclooxygenase-2 (COX-2). The ERK inhibitor, PD98059, significantly attenuated the up-regulatory effect of SIN on cPLA2 phosphorylation. Interestingly, SIN did not significantly increase Ca(2+) influx in the cells. These findings not only explored the anaphylactic reaction and underlying mechanism of ZQFTN in RBL-2H3 cells, but may promote the development of relevant strategies for overcoming the adverse effects of the drug.

  12. [Total thyroidectomy treatment of bening multinodular goiter].

    PubMed

    Palas, César; Álvarez, Facundo; Ferreira, Gastón; Gramática, Luis h

    2014-01-01

    Introducción. El tratamiento del bocio multinodular beningo (BMNB) es motivo de continuo debate en las últimas décadas pese a la evidencia de que la tiroidectomía total (TT) está relacionada a una reducción significativa en la recurrencia de la enfermedad y a una mínima morbilidad en manos entrenadas. Objetivo. Determinar la recurrencia del BMNB al cabo de 10 años en 100 pacientes tratados con TT y evaluar las complicaciones relacionadas a la técnica.Diseño. Prospectivo no randomizado.Material y métodos. Desde marzo del 1999 a marzo del 2001, cien pacientes, 95 del sexo femenino, con un promedio de edad de 42,4 años (rango: 23-67), fueron sometidos a una TT por padecer un BMNB, el cual fue confirmado por la ecografía cervical, la que además sirvió de guía para realizar la punción aspiración con aguja fina (PAAF). En todos los casos se realizó un laringoscopía inderecta pre y post postquirúrgica. Resultados. El tiempo operatorio promedio fue de 49 minutos (rango: 35-58). Registramos una parálisis recurrencial (1%) y cinco hipoparatiroidismos (5%), ambos transitorios y ningún caso definitivo. Todos los pacientes fueron dados de alta antes de las 24 horas de la cirugía. No objetivamos ninguna recurrencia del BMNB en un período de seguimiento de más de 10 años.Conclusión. La TT es el tratamiento elección del BMNB, por ser un procedimiento eficaz, seguro, con mínimas tasas de complicaciones y por evitar o reducir significativamente la recurrencia de esta enfermedad.

  13. Association Analysis of Grain-setting Rates in Apical and Basal Spikelets in Bread Wheat (Triticum aestivum L.)

    PubMed Central

    Guo, Jie; Zhang, Yong; Shi, Weiping; Zhang, Boqiao; Zhang, Jingjuan; Xu, Yanhao; Cheng, Xiaoming; Cheng, Kai; Zhang, Xueyong; Hao, Chenyang; Cheng, Shunhe

    2015-01-01

    The rates of grain-setting in apical and basal spikelets in wheat directly affect the kernel number per spike (KNPS). In this study, 220 wheat lines from 18 Chinese provinces and five foreign countries were used as a natural population. Phenotypic analysis showed differences in grain-setting rates between apical and basal spikelets. The broad-sense heritability of grain-setting rate in apical spikelets (18.7–21.0%) was higher than that for basal spikelets (9.4–16.4%). Significant correlations were found between KNPS and grain numbers in apical (R2 = 0.40–0.45, P < 0.01) and basal (R2 = 0.41–0.56, P < 0.01) spikelets. Seventy two of 106 SSR markers were associated with grain setting, 32 for apical spikelets, and 34 for basal spikelets. The SSR loci were located on 17 chromosomes, except 3A, 3D, 4A, and 7D, and explained 3.7–22.9% of the phenotypic variance. Four markers, Xcfa2153-1A202, Xgwm186-5A118, Xgwm156-3B319, and Xgwm537-7B210, showed the largest effects on grain numbers in apical and basal spikelets. High grain numbers in apical and basal spikelets were associated with elite alleles. Ningmai 9, Ning 0569, and Yangmai 18 with high grain-setting rates carried larger numbers of favorable alleles. Comparison of grain numbers in basal and apical spikelets of 35 Yangmai and Ningmai lines indicated that the Ningmai lines had better grain-setting rates (mean 21.4) than the Yangmai lines (16.5). PMID:26635852

  14. [Prevalence of metabolic syndrome and insulin resistance in system sclerosis].

    PubMed

    Peralta-Amaro, Ana Lilia; Cruz-Domínguez, María del Pilar; Olvera-Acevedo, Arturo; Vera-Lastra, Olga Lidia

    2015-01-01

    Introducción: el síndrome metabólico (SM) es un conjunto de factores de riesgo cardiovascular cuya prevalencia se encuentra incrementada en enfermedades reumáticas. El objetivo de este estudio fue estimar la prevalencia de SM y resistencia a la insulina (RI) en esclerosis sistémica (ES). Métodos: se incluyeron 55 pacientes con ES. Se evaluó SM utilizando los criterios de la OMS. Se registraron datos demográficos, antropométricos y presión arterial. Se midieron valores de glucosa, colesterol de lipoproteínas de alta densidad (c-HDL), triglicéridos e insulina. Se realizó una curva de tolerancia oral a la glucosa para identificar intolerancia a la glucosa y diabetes mellitus en pacientes con glucosa normal en ayuno. Se calculó el índice HOMA y se cuantificó proteinuria en orina de 24 horas. Resultados: la prevalencia del SM fue del 36.4 %. El 70 % de los pacientes con SM correspondió a ES limitada y 30 % a ES difusa. Se observó mayor resistencia a la insulina (RI) en la ES limitada frente a ES difusa. Se encontró asociación entre RI y el SM en la forma limitada. Del resto de los criterios de SM, la hipertrigliceridemia y el índice cintura/cadera anormal fueron las variables más frecuentes, 95 % y 85 % respectivamente. El 50 % de los pacientes con SM tuvo niveles bajos de c-HDL, e hipertensión arterial sistémica 40 %. En ningún paciente hubo proteinuria. Conclusiones: la prevalencia de SM en ES fue del 36.4 %, similar a la encontrada en otras enfermedades reumáticas, pero mayor en comparación con la población mexicana.

  15. EXTENSION OF THE INVERSE ADDING-DOUBLING METHOD TO THE MEASUREMENT OF WAVELENGTH-DEPENDENT ABSORPTION AND SCATTERING COEFFICIENTS OF BIOLOGICAL SAMPLES

    SciTech Connect

    Allegood, M.S.; Baba, J.S.

    2008-01-01

    Light interaction with biological tissue can be described using three parameters: the scattering and absorption coeffi cients (μs and μa), as well as the anisotropy (g) which describes the directional dependence of the scattered photons. Accurately determining these optical properties for different tissue types at specifi c wavelengths simultaneously would be benefi cial for a variety of different biomedical applications. The goal of this project was to take a user defi ned g-value and determine the remaining two parameters for a specifi ed wavelength range. A fully automated computer program and process was developed to collect data for all wavelengths in a timely and accurate manner. LabVIEW® was used to write programs to automate raw intensity data collection from a spectrometer equipped integrating sphere, conversion of the data into a format for analysis via Scott Prahl’s Inverse Adding-Doubling (IAD) C code execution, and fi nally computation of the optical properties based on the output from the IAD code. To allow data to be passed effi ciently between LabVIEW® and C code program modules, the two were combined into a single program (OPT 3.1). OPT 3.1 was tested using tissue mimicking phantoms. Determination of the absorption and scattering coeffi cients showed excellent agreement with theory for wavelengths where the user inputted single g-value was suffi ciently precise. Future improvements entail providing for multi-wavelength g-value entry to extend the accuracy of results to encompass the complete multispectral range. Ultimately, the data collection process and algorithms developed through this effort will be used to examine actual biological tissues for the purpose of building and refi ning models for light-tissue interactions.

  16. [Preventive program for postoperative delirium in the elderly].

    PubMed

    Ocádiz-Carrasco, Jesús; Gutiérrez-Padilla, Ruth Alicia; Páramo-Rivas, Frida; Serrano, Alejandro Tovar; Hernández-Ortega, José Luis

    2013-01-01

    Antecedentes: el delirium es un padecimiento poco reconocido en los pacientes quirúrgicos que frecuentemente se confunde con deterioro cognitivo o demencia. Es de vital importancia conocer las medidas que pueden disminuir su incidencia y reconocerlo de manera temprana para iniciar el tratamiento específico. Objetivo: implementar un programa educativo en delirium para el equipo de salud, con el propósito de disminuir su incidencia. Material y métodos: estudio observacional, longitudinal y analítico basado en medidas no farmacológicas y con apoyo de los familiares con quienes se tuvieron sesiones educativas, material didáctico, cuestionarios y estrategias específicas para todos los pacientes mayores de 65 años. Se realizaron dos evaluaciones al personal médico y de enfermería antes y después de implementar el programa.Resultados: se observó mejoría en la capacidad para dentificar el delirium (22% inicial vs 93%; p= 0.000). Se incluyeron 200 pacientes en el grupo de ensayo a un año y se encontró un solo caso de delirium que mostró reducción importante respecto a la incidencia previa en el hospital (10 vs 0.5% p= 0.000), mientras que en el subgrupo de 98 pacientes quirúrgicos no hubo ningún caso de delirium (4.8% inicial vs 0% p= 0.01, NNT= 21). Conclusiones: la implementación de un programa preventivo para el delirium es factible. Los resultados fueron satisfactorios, por lo que puede considerarse una estrategia efectiva para reducir la incidencia de esta afección que puede causar gran morbilidad y mortalidad postoperatoria.

  17. [Efficacy of zinc on lineal growth on Latin American children younger than 5; systematic review].

    PubMed

    Jiménez-Morán, Elsa; Bacardí-Gascón, Montserrat; Jiménez-Cruz, Arturo

    2013-01-01

    Antecedentes: En la mayoría de los países latinoamericanos existe una deficiencia de micronutrientes, retraso en el crecimiento, y altas tasas de morbilidad y mortalidad infantil. En la actualidad se ha asociado la deficiencia de zinc con el retraso del crecimiento infantil. El propósito de esta revisión, fue analizar artículos sobre estudios aleatorizados que evaluaron el efecto de la suplementación con zinc y el crecimiento infantil. Metodología: Se realizó una búsqueda electrónica de la literatura en la base de datos de PubMed con las palabras claves “Micronutrient supplementation and growth”, publicados de enero de 2005 a abril de 2013. Se identificaron 34 estudios aleatorizados controlados (EAC) realizados en Latinoamérica, de los cuales cinco reunieron los criterios de inclusión. Se añadió un estudio referido por otros autores. Resultados: Los estudios se realizaron en Brasil, Cuba, Perú, Ecuador, y Guatemala. En ningún estudio se observó el efecto positivo del zinc sobre el crecimiento lineal. Conclusión: La revisión realizada sugiere que la suplementación con zinc no tiene un efecto significativo sobre el crecimiento lineal; sin embargo, podría tener beneficios sobre el crecimiento en niños con deficiencia de zinc si se añaden otros nutrientes en deficiencia.

  18. Unidata Workshop: Demonstrating Democratization of Numerical Weather Prediction Capabilities Using Linked Environments for Atmospheric Discovery (LEAD) Capabilities

    NASA Astrophysics Data System (ADS)

    Baltzer, T.; Wilson, A.; Marru, S.; Rossi, A.; Christi, M.; Hampton, S.; Gannon, D.; Alameda, J.; Ramamurthy, M.; Droegemeier, K.

    2006-12-01

    On July 13th 2006 during the triannual Unidata Workshop, members of the Unidata community got their first experience with capabilities being developed under the Linked Environments for Atmospheric Discovery (LEAD) project (see: http://lead.ou.edu). The key LEAD goal demonstrated during the workshop was that of "Democratization," that is, providing capabilities that typically have a high barrier to entry to the larger meteorological community. At the workshop, participants worked with software that demonstrated the specific concepts of: 1) Lowering the barrier to entry by making it easy for users to: - Experiment using meteorological tools - Create meteorological forecasts - Perform mesoscale modeling and forecasting - Access data (source and product) - Make use of large scale cyberinfrastructure (E.g. TeraGrid) 2) Giving users the freedom from technological issues such as: - Hassle-free access to supercomputing resources - Hassle-free execution of forecast models and related tools - Data format independence This talk will overview the capabilities presented to the Unidata workshop participants as well as capabilities developed since the workshop. There will also be a lessons-learned section. This overview will be accomplished with a live demonstration of some of the capabilities. Capabilities that will be discussed and demonstrated have applicability across many disciplines e.g. discovering, acquiring and using data and orchestrating of complex workflow. Acknowledgement: The LEAD project involves the work of nearly 100 individuals whose dedication has resulted in the capabilities that will be shown here. The authors would like to recognize all of them, but in particular we'd like to recognize: John Caron, Rich Clark, Ethan Davis, Charles Hart, Yuan Ho, Scott Jenson, Rob Kambic, Brian Kelly, Ning Liu, Jeff McWhirter, Don Murray, Beth Plale, Rahul Ramachandran, Yogesh Simmhan, Kevin Thomas, Nithya Vijayakumar, Yunheng Wang, Dan Weber, and Bob Wilhelmson.

  19. Comparing paraffined and deparaffinized breast cancer tissue samples and an analysis of Raman spectroscopy and infrared methods

    NASA Astrophysics Data System (ADS)

    Depciuch, J.; Kaznowska, E.; Szmuc, K.; Zawlik, I.; Cholewa, M.; Heraud, P.; Cebulski, J.

    2016-05-01

    Breast cancer makes up a quarter of all cancer in women, which is why research into new diagnostic methods and sample preparations need to be developed at an accelerated pace. Researchers are looking for diagnostic tools to detect when an individual has cancer cells and use that information to see what measurements and approaches can be used to take further diagnostic steps. The most common method of sample preparation is the imbibing of tumor tissue in paraffin, which can produce a background for spectroscopic measurements in the range of 500-3500 cm-1. In this study we demonstrated that proper preparation of paraffin-embedded specimens and the measurement methodology can eliminate paraffin vibration, as was done in the work Depciuch et al. 2015. Thanks to this spectroscopic technique there may become a reliable and accurate method of diagnosing breast cancer based on the evidence found from the prepared samples. The study compared the results obtained through Raman spectroscopy and FTIR (Fourier Transform Infrared) measurements of healthy and cancerous breast tissues that were either embedded in paraffin or deparaffinized. The resulting spectrum and accurate analysis led to the conclusion that the appropriate measurement of the background and the elimination of peaks from the paraffin had the greatest impact on the reliability of results. Furthermore, after the accurate, detailed studies FTIR and Raman spectroscopy on samples of breast tissue that were deparaffinized or embedded in paraffin, including a complete analysis of the peak after transformation Kramers-Kröning (KK), it was found that sample preparation did not affect the result obtained by measuring the reflectance in the mid-infrared range, and that this only had a minimal effect relating to the intensity obtained by the measurement of the Raman peak. Only in special cases, when Raman spectroscopic methods are used for research to find the peculiarities of the spectra, are deparaffinization recommended

  20. Climate change effects on extreme flows of water supply area in Istanbul: utility of regional climate models and downscaling method.

    PubMed

    Kara, Fatih; Yucel, Ismail

    2015-09-01

    This study investigates the climate change impact on the changes of mean and extreme flows under current and future climate conditions in the Omerli Basin of Istanbul, Turkey. The 15 regional climate model output from the EU-ENSEMBLES project and a downscaling method based on local implications from geophysical variables were used for the comparative analyses. Automated calibration algorithm is used to optimize the parameters of Hydrologiska Byråns Vattenbalansavdel-ning (HBV) model for the study catchment using observed daily temperature and precipitation. The calibrated HBV model was implemented to simulate daily flows using precipitation and temperature data from climate models with and without downscaling method for reference (1960-1990) and scenario (2071-2100) periods. Flood indices were derived from daily flows, and their changes throughout the four seasons and year were evaluated by comparing their values derived from simulations corresponding to the current and future climate. All climate models strongly underestimate precipitation while downscaling improves their underestimation feature particularly for extreme events. Depending on precipitation input from climate models with and without downscaling the HBV also significantly underestimates daily mean and extreme flows through all seasons. However, this underestimation feature is importantly improved for all seasons especially for spring and winter through the use of downscaled inputs. Changes in extreme flows from reference to future increased for the winter and spring and decreased for the fall and summer seasons. These changes were more significant with downscaling inputs. With respect to current time, higher flow magnitudes for given return periods will be experienced in the future and hence, in the planning of the Omerli reservoir, the effective storage and water use should be sustained.

  1. Structural characterization of the pulmonary innate immune protein SPLUNC1 and identification of lipid ligands

    PubMed Central

    Ning, Fangkun; Wang, Chao; Berry, Karin Zemski; Kandasamy, Pitchaimani; Liu, Haolin; Murphy, Robert C.; Voelker, Dennis R.; Nho, Chu Won; Pan, Choel-Ho; Dai, Shaodong; Niu, Liwen; Chu, Hong-Wei; Zhang, Gongyi

    2014-01-01

    The short palate, lung and nasal epithelial clone 1 (SPLUNC1) protein is a member of the palate, lung, and nasal epithelium clone (PLUNC) family, also known as bactericidal/permeability-increasing (BPI) fold-containing protein, family A, member 1 (BPIFA1). SPLUNC1 is an abundant protein in human airways, but its function remains poorly understood. The lipid ligands of SPLUNC1 as well as other PLUNC family members are largely unknown, although some reports provide evidence that lipopolysaccharide (LPS) could be a lipid ligand. Unlike previous hypotheses, we found significant structural differences between SPLUNC1 and BPI. Recombinant SPLUNC1 produced in HEK 293 cells harbored several molecular species of sphingomyelin and phosphatidylcholine as its ligands. Significantly, in vitro lipid-binding studies failed to demonstrate interactions between SPLUNC1 and LPS, lipoteichoic acid, or polymyxin B. Instead, one of the major and most important pulmonary surfactant phospholipids, dipalmitoylphosphatidylcholine (DPPC), bound to SPLUNC1 with high affinity and specificity. We found that SPLUNC1 could be the first protein receptor for DPPC. These discoveries provide insight into the specific determinants governing the interaction between SPLUNC1 and lipids and also shed light on novel functions that SPLUNC1 and other PLUNC family members perform in host defense.—Ning, F., Wang, C., Berry, K. Z., Kandasamy, P., Liu, H., Murphy, R. C., Voelker, D. R., Nho, C. W., Pan, C.-H., Dai, S., Niu, L., Chu, H.-W., Zhang, G. Structural characterization of the pulmonary innate immune protein SPLUNC1 and identification of lipid ligands. PMID:25223608

  2. Forskolin stimulates detoxification of brefeldin A.

    PubMed

    Nickel, W; Helms, J B; Kneusel, R E; Wieland, F T

    1996-07-05

    Forskolin has been shown to prevent the effects brefeldin A (BFA) exerts on many mammalian cells with respect to the disassembly of the Golgi apparatus as well as an increase of sphingomyelin synthesis (Lippincott, S. J., Glickman, J., Donaldson, J. G., Robbins, J., Kreis, T. E., Seamon, K. B., Sheetz, M. P., and Klausner, R. D. (1991) J. Cell Biol. 112, 567-577). It has been speculated that forskolin interferes with the action of BFA by competition for the binding of BFA to its target protein, which is most likely the Golgi-localized nucleotide exchange factor specific for ADP-ribosylation factor 1. Here we show that in vitro forskolin does not prevent inhibition of Golgi-catalyzed nucleotide exchange by BFA. Therefore it appears unlikely that forskolin and BFA bind to the same target protein. Using [3H]BFA we have measured detoxification of BFA by Chinese hamster ovary (CHO) cells. BFA is secreted from CHO cells as cysteine and glutathione conjugates (Brüning, A., Ishikawa, T., Kneusel, R. E., Matern, U., Lottspeich, F., and Wieland, F. T. (1992) J. Biol. Chem. 267, 7726-7732). We present evidence that forskolin treatment of CHO cells results in increased levels of Cys-BFA, the major BFA conjugate secreted by CHO cells, in the medium. Elevated levels of Cys-BFA are also found intracellularly. The effect of forskolin is shown to be independent of its ability to raise the intracellular concentration of cyclic AMP. Therefore, we suggest that the effect of forskolin on BFA-induced disassembly of the Golgi apparatus might be due to an enhanced detoxification of the drug.

  3. Cancer mortality in chinese populations surrounding an alloy plant with chromium smelting operations.

    PubMed

    Kerger, Brent D; Butler, William J; Paustenbach, Dennis J; Zhang, JianDong; Li, ShuKun

    2009-01-01

    This report is a further characterization of data from an ecological cancer mortality study of a population (about 10,000) exposed to groundwater contaminated by hexavalent chromium [Cr(VI)] up to 20 mg/L near JinZhou City in the LiaoNing Province of China between 1960 and 1978. Prior reports showed an elevation in all-cancer mortality from 1970 to 1978 averaged across five agricultural villages with Cr(VI) in groundwater relative to average cancer rates for the district and province. The current study compares the cancer rates during the same time period for the same five exposed villages to those of four nearby areas with no Cr(VI) in groundwater. The use of a local comparison group is considered superior to the use of district or province averages because of the expected improved similarity among unmeasured covariates in nearby areas. The average lung-, stomach-, and all-cancer mortality rates for the three agricultural villages without Cr(VI) in groundwater were not statistically different from those of the five agricultural villages with Cr(VI) in groundwater. Also, three surrogate measures of village drinking-water Cr(VI) dose did not significantly correlate with cancer mortality rates in the five exposed villages. Further, the industrial town in which the Cr(VI) source was located had different demographics and a different pattern of stomach and lung cancers compared to the adjacent agricultural villages, regardless of Cr(VI) groundwater exposure. The results of other local investigations on cancer mortality and genotoxicity in the exposed populations are reviewed. The overall findings in the studied population do not indicate a dose-response relationship or a coherent pattern of association of lung-, stomach-, or all-cancer mortality with exposure to Cr(VI)-contaminated groundwater.

  4. Clinical and Demographic Characteristics of Binge Drinkers Associated with Lack of Efficacy of Brief Intervention and Medical Advice.

    PubMed

    Rubio, Gabriel; López-Rodríguez, Juan A; Zuluaga, Pilar; Ponce, Guillermo; Martínez-Gras, Isabel; Jiménez-Arriero, Miguel Ángel

    2015-06-17

    La Intervención Breve (IB) y el Consejo Médico simple (CM) son intervenciones psicoterapéuticas usadas para el tratamiento del consumo de alcohol por atracones en Atención Primaria. A pesar de la frecuencia de este patrón de abuso en Europa y en los Estados Unidos, ningún estudio ha evaluado las características de los sujetos que no responden a esas dos técnicas. Objetivo. Determinar las características demográficas y clínicas de los bebedores por atracones en los que la IB y el CM no son efectivos para la reducción del consumo perjudicial de alcohol. Métodos. Se trata de un análisis secundario de los datos obtenidos en un ensayo aleatorizado de intervención breve en alcohol con un período de seguimiento de 12 meses. Un total de 674 sujetos (89%) participaron durante todo el estudio hasta el final. La variable principal fue el cambio en el uso perjudicial de alcohol tras 12 meses de seguimiento. Resultados. Para ambos grupos de tratamiento las variables que predecían la continuidad en el consumo perjudicial tras el seguimiento eran: bajo nivel educativo, ser jóvenes, el número de cigarrillos fumados, la historia familiar de alcoholismo y la gravedad del consumo de alcohol basalmente. Conclusiones. Las características clínicas y sociodemográficas de los sujetos con un patrón de consumo de alcohol por atracones atendidos en Atención primaria influyen en el pronóstico de las Intervenciones breves y del Consejo Médico.

  5. Sediment regime constraints on river restoration - An example from the lower missouri river

    USGS Publications Warehouse

    Jacobson, R.B.; Blevins, D.W.; Bitner, C.J.

    2009-01-01

    , provides a quantitative basis for defi ning management constraints and identifying opportunities. ?? 2009 The Geological Society of America.

  6. MicroCameras and Photometers (MCP) instrument on board TARANIS satellite: scientific objectives, design, characterization results and products

    NASA Astrophysics Data System (ADS)

    Farges, T.; Hébert, P.; Le Mer-Dachard, F.; Cansot, E.; Offroy, M.; Ravel, K.; Gaillac, S.; Sato, M.; Blanc, E.

    2015-12-01

    TARANIS (Tool for the Analysis of Radiations from lightNings and Sprites) is a CNES micro satellite. Its main objective is to study impulsive transfers of energy between the Earth atmosphere and the space environment. It will be sun-synchronous at an altitude of 700 km. It will be launched from late 2017 for at least 2 years. Its payload is composed of several electromagnetic instruments in different wavelengths (from gamma-rays to radio waves including optical). TARANIS instruments are currently in calibration and qualification phase. The purpose of this poster is to present the MicroCameras and Photometers (MCP) scientific objectives and the sensor design, to show the performances of this instrument using the recent characterization, and at last to promote its products. The MicroCameras, developed by Sodern, are dedicated to the spatial description of TLEs and their parent lightning. They are able to differentiate sprite and lightning thanks to two narrow bands ([757-767 nm] and [772-782 nm]) that provide simultaneous pairs of images of an Event. The calibration results will be detailed. Simulation results of the differentiation method will be shown. Photometers, developed by Bertin Technologies, will provide temporal measurements and spectral characteristics of TLEs and lightning. It is a key instrument because of its on-board detection of the TLEs which can trigger the whole payload. Photometers use four spectral bands in the [170-260 nm], [332-342 nm], [757-767 nm] and [600-900 nm] and have the same field of view as cameras. The calibration results will also be detailed. The on-board TLE detection algorithm remote-controlled parameters will be tuned before launch using the electronic board and simulated or real events waveforms. Automatic classification tools are now tested to produce for the Scientific Mission Center some lists of elves, sprites or lightning without TLE following the recent work of Offroy et al. [2015] using ISUAL spectrophotometer data.

  7. [Ultraviolet absorption spectrum analysis and identification of medicinal plants of Paris].

    PubMed

    Zhang, Jin-yu; Wang, Yuan-zhong; Zhao, Yan-li; Yang, Shao-bing; Zhang, Ji; Yuan, Tian-jun; Wang, Jia-jun; Jin, Hang

    2012-08-01

    Species of Paris are important medicinal plants of China. They possess anticancer, hot alexipharmic, detumescence, acesodyne, and arrest blood and remove blood stasis effects. They are the main raw material for several Chinese patent drugs such as "Yunnan Baiyao", "Gong Xue Ning", "Re Du Qing" and "Ji De Sheng Sheyaopian". The present paper, through optimizing the chloroform, absolute ethyl alcohol and water extraction condition of Paris by orthogonal test L3(4) (16), using mean value, smoothness and second differential methods on the observed UV spectrum, to inspects the RSD of stability and repeatability of different waveband. By SIMCA and the common and variant peak ratio dual index sequence analysis method, it evaluated the quality and quantity of Paris. The results showed that at the time of 50, 40 and 50 min, chloroform, absolute ethyl alcohol and water had the highest extraction ratios. Within 20 h, the RSDs of stability were 0.06-1.88, 0.05-2.42 and 0.03-0.35; the RSDs of accuracy were 0-1.48, 0.05-0.37 and 0.09-0.44; and the RSDs of repeatability were 0-1.23, 0.04-0.30 and 0.12-0.25 respectively. The qualitative analysis revealed large differences between different Paris species and different areas. The quantitative analysis indicated that the highest common peak ratio among the Paris samples was 80.00% and the lowest variant peak ratio was 6.25%. The method evaluated Paris of different species and from different producing areas, and also quantitatively assessed the arbitrary two samples, clarified the similarity between the species and areas of Paris, which provided basis of distinguishing the real and false, identification of variety and quality evaluation for Chinese herbal medicine.

  8. Design and development of a nutritional assessment application for smartphones and tablets with Android OS.

    PubMed

    Carnero Gregorio, Miguel; Blanco Ramos, Montserrat; Obeso Carillo, Gerardo Andrés; García Fontán, Eva; Álvarez González, Miguel Ángel; Cañizares Carretero, Miguel Ángel

    2014-10-03

    Introducción y objetivos: Diseñar y desarrollar una aplicación nutricional para smartphones y tablets con Sistema operativo Android® para realizar las valoraciones nutricionales de pacientes ambulatorios y hospitalizados. Verificar y comprobar la validez de los resultados de la aplicación. Métodos: La aplicación se compile para la versión 2.1 del Sistema operativo Android® de Google®. Para evaluar la fiabilidad de la aplicación se incluyeron a 30 pacientes, a los que se le realizó una valoración nutricional. Todos los cálculos fueron efectuados por personal de la Unidad de Nutrición del Complexo Hospitalario Universitario de Vigo, de forma manual y a través del software e-Nutrimet ©, tanto usando un Smartphone como una tablet. Resultados: Se obtuvo una concordancia absoluta entre los resultados de los diferentes métodos obtenidos utilizando la aplicación e-Nutrimet© en smartphones y en tablets (Fleiss index = 1). El mismo nivel de concordancia se obtuvo comparando el método manual como el automatizado mediante el software e-Nutrimet©. Conclusiones: El grado de correlación es muy bueno, permitiendo extender la valoración nutricional usando e-Nutrimet© a todo el personal sanitario que quiera determinar si un paciente presenta malnutrición o no. La aplicación de valoración nutricional e-Nutrimet© no sustituye al personal sanitario en ningún caso, pero podría ser de gran ayuda a la hora de valorar pacientes que pudieran estar en riesgo de malnutrición, ahorrando tiempo en estas valoraciones.

  9. Negative-weight Percolation: Review of Existing Literature and Scaling Behavior of the Path Weight in 2d

    NASA Astrophysics Data System (ADS)

    Melchert, O.; Norrenbrock, C.; Hartmann, A. K.

    We consider the negative weight percolation (NWP) problem on hypercubic lattice graphs with fully periodic boundary condi- tions in all relevant dimensions from d = 2 to the upper critical dimension d = 6. The problem exhibits edge weights drawn from disorder distributions that allow for weights of either sign. We are interested in the statistical properties of the full ensemble of loops with negative weight, i.e. non-trivial (system spanning) loops as well as topologically trivial ("small") loops that comprise the "loops only" variant of the NWP problem. The NWP phenomenon refers to the disorder driven proliferation of system span- ning loops of total negative weight. For the numerical simulations we employ a mapping of the NWP model to a combinatorial optimization problem that can be solved exactly by using sophisticated matching algorithms. This allows for the numerically exact study of large systems with good statistics, important to ensure a reliable disorder average. Early simulations for the 2d setup led to suggest that the resulting negative-weight percolation (NWP) problem is fundamentally different from conventional percolation. Here, we review several studies that reported on results of numerical simulations aimed at clarifying the geometric properties of NWP on hypercubic lattice graphs and random graphs. Finally we present additional new results for the scaling behavior of the geometric properties and the configurational weight of minimum-weight paths (MWPs) in the "loops + MWP" variant of the model, characterizing an additional threshold ?, above which the disorder averaged MWP weight (ωp) is negative, thereby highlighting a characteristic limiting case of the NWP model at small densities of negative edges.

  10. Translucent poly(vinyl alcohol) cryogel dosimeters for simultaneous dose buildup and monitoring during chest wall radiation therapy.

    PubMed

    Eyadeh, Molham M; Weston, Mark A; Juhasz, Janos; Diamond, Kevin R

    2016-09-08

    Chest wall radiation therapy treatment delivery was monitored using a 5 mm thick radiochromic poly(vinyl alcohol) cryogel that also provided buildup material. The cryogels were used to detect positioning errors and measure the impact of shifts for a chest wall treatment that was delivered to a RANDO phantom. The phantom was shifted by ± 2, ± 3, and ± 5 mm from the planned position in the anterior/posterior (A/P) direction; these shifts represent setup errors and the uncertainty associated with lung filling during breath-hold. The two-dimensional absolute dose distributions measured in the cryogel at the planned position were compared with the distributions at all shifts from this position using gamma analysis (3%/3 mm, 10% threshold). For shifts of ± 2, ± 3, and ± 5 mm the passing rates ranged from 94.3% to 95.6%, 74.0% to 78.8%, and 17.5% to 22.5%, respectively. These results are consistent with the same gamma analysis performed on dose planes calculated in the middle of the cryogel and on the phantom surface using our treatment plan-ning system, which ranged from 94.3% to 95.0%, 76.8% to 77.9%, and 23.5% to 24.3%, respectively. The Pinnacle dose planes were then scaled empirically and compared to the cryogel measurements. Using the same gamma metric, the pass rates ranged from 97.0% to 98.4%. The results of this study suggest that cryogels may be used as both a buildup material and to evaluate errors in chest wall treat-ment positioning during deep-inspiration breath-hold delivery. The cryogels are sensitive to A/P chest wall shifts of less than 3 mm, which potentially allows for the detection of clinically relevant errors.

  11. [Correlation of heart rate variability with SYNTAX II on chronic angina].

    PubMed

    Castro-de la Torre, Tatiana Chantal; Amador-Licona, Norma; Bernal-Ruíz, Enrique

    2017-01-01

    Introducción: la variabilidad de la frecuencia cardiaca (VFC) es un valor pronóstico de riesgo cardiovascular. Se desconoce su correlación con la severidad de la cardiopatía isquémica estable. El objetivo fue conocer la correlación de la VFC con la puntuación SYNTAX II en angina crónica. Métodos: estudio transversal en pacientes mayores de 18 años con angina estable e indicación de coronariografía diagnóstica que asistieron a un centro de tercer nivel. Mediante coronariografía se estableció la puntuación SYNTAX II y se obtuvo la VFC por Holter de 24 horas. La correlación de las mediciones se obtuvo con la prueba de Pearson. Un valor de SDNN < 100 ms y de RMSSD < 15 ms se consideró de riesgo. Resultados: se incluyeron 61 pacientes. De ellos, 45 tenían disminución de los valores de SDNN (73.77%) y solo 8 tenían disminución de los valores RMSSD (13.11%). No hubo correlación de ningún parámetro de VFC con SYNTAX II. Hubo mayor frecuencia de taquicardia ventricular en el grupo SDNN bajo en comparación con SDNN normal (15.5 frente a 0.0%; p = 0.04). Conclusiones: no identificamos correlación de parámetros de VFC con la severidad de cardiopatía isquémica crónica. Sin embargo, aquellos pacientes con menor VFC presentaron mayor proporción de taquicardia ventricular.

  12. Coupling between the atmosphere, the ionosphere and the magnetosphere : Project of microsatellite Taranis

    NASA Astrophysics Data System (ADS)

    Blanc, E.; Taranis Team

    2003-04-01

    Strong interactions between the middle and upper regions of the atmosphere and ionosphere are manifested by light emission in the middle and upper atmosphere, known as sprites and elves, gamma radiation of atmospheric origin, electromagnetic emissions recently observed above atmospheric storms. This direct coupling between active storm cells, the thermosphere and the ionosphere - and the considerable energies involved - gives rise to processes unsuspected until now regarding space plasmas as well as the chemistry and dynamics of the middle atmosphere. The electromagnetic and particle emissions could derive from the run away relativistic electrons initiated by the impact of cosmic rays on storm cells. These processes can have a significant effect on the Earth's magnetosphere, in particular by modifying the source terms and loss of the radiation belts. The microsatellite Taranis (Tool for the Analysis of RAdiations from lightNIngs and Sprites) proposes to study the coupling between atmosphere, ionosphere and magnetosphere during atmospheric storms. This has to be carried on a local and global scale in order to understand the physical mechanisms responsible for the impulsive transfers of energy between the neutral atmosphere and plasmas of the ionosphere and magnetosphere. The final goal is to establish the impact of these processes on the Earth's environment. The purpose of this presentation is to describe in a first part the project Taranis, his scientific objectives, the mission and the scientific payload. In a second part the first results of the experiment LSO (Lightning and Sprite Observations), on board of the International Space Station, will be presented. LSO is composed of two micro-cameras, fixed on a ISS window for observations at the horizon or at the nadir. One camera is equipped with a filter and measures the emissions from earth in a specific spectral window, the second works in the visible. The measurements allow the identification of sprites and

  13. Accident vasculaire cérébral hémorragique mortel suite à une envenimation par une vipère à corne en Tunisie

    PubMed Central

    Ghezala, Hassen Ben; Snouda, Salah

    2015-01-01

    En Tunisie, parmi les envenimations par animaux terrestres, les morsures de vipéridés sont, après les piqûres de scorpions, les plus fréquentes. La présence d'un syndrome hémorragique est un des principaux critères de gravité. Nous rapportons le cas fatal d'une envenimation vipérine chez un patient de 37 ans sans antécédents qui a consulté nos urgences dans les suites d'une morsure de vipère. L'examen initial note un œdème local de la main gauche avec des ecchymoses et la trace de morsure. Initialement le patient est conscient. La biologie initiale est strictement normale. Quatre heures après son admission, le patient présente brutalement une altération de l’état de conscience. Le scanner cérébral pratiqué en urgence conclut à la présence d'hémorragie méningée, d'hématomes intra cérébraux et de lésions ischémiques diffuses. La biologie de contrôle révèle une coagulation intravasculaire disséminée (CIVD). L’évolution est rapidement défavorable avec décès du patient dans un tableau de coma dépassé. PMID:26327993

  14. [Obesity associated risk using Edmonton staging in bariatric surgery].

    PubMed

    de Cos, Ana Isabel; Cardenas, Jersy J; Pelegrina, Beatriz; Roldan, M Concepción; Calvo, Isabel; Vázquez, Clotilde; Pallardo, Luis Felipe

    2014-09-20

    Con una prevalencia de obesidad mórbida del 1,2% en población española, los criterios de indicación para Cirugía Bariátrica (CB) no consideran comorbilidades ni estado funcional. Es necesaria una aproximación diagnóstica capaz de predecir mortalidad y sustentar criterios de priorización terapéutica. Objetivo: Aplicar la propuesta Edmonton como sistema de estadiaje clínico para la clasificación de pacientes en lista de espera de CB. Método: Se recogen datos de 81 pacientes (2011 – 2013), tras protocolo prequirúrgico. Se registra peso, talla, IMC, cintura, determinaciones bioquímicas, TA, presencia de enfermedad hepática, renal, osteoarticular, síndrome apnea-hipopnea del sueño (SAHS) y reflujo gastroesofágico. Se aplica a cada persona la propuesta de estadiaje de Edmonton, con 10 variables. Resultados: 67% mujeres. Edad media: 47 años, 18% con edad inferior a 30 años. IMC medio: 47 (37-67), 90% IMC > de 40. El 34% de los pacientes presentan SHAS y el 25% enfermedad por reflujo. Un 9% asocia IMC > 45, disglucosis- diabetes mellitus y SAHS. Aplicando el modelo de Edmonton, nueve pacientes (11%) se sitúan en el rango de mayor riesgo (estadío 3), 70% en rango de riesgo elevado (estadío 2), y 15 pacientes (18%), están incluidos en la condición de bajo riesgo. Ningún paciente se situaba en estadio 0, sin factores de riesgo asociados a obesidad. Conclusiones: El estadiaje de Edmonton nos aporta información sobre la presencia y extensión de co-mobilidades, que apoye la toma de decisiones terapéuticas. La capacidad predictiva de mortalidad de la propuesta de Edmonton podría ser útil para establecer criterios de priorización quirúrgica.

  15. Validation of beverage intake methods vs. hydration biomarkers; a short review.

    PubMed

    Nissensohn, Mariela; Ruano, Cristina; Serra-Majem, Lluis

    2013-11-01

    Resumen: Introducción: La ingesta de líquidos es difícil de monitorear. Los biomarcadores de ingesta de bebidas son capaces de evaluar la ingesta dietética / estado de hidratación sin el sesgo producido por los errores de los auto- registros de ingesta dietaria, así como por la variabilidad intra-individual. Se han propuesto diversos marcadores para evaluar el estado de hidratación; sin embargo, hasta la fecha, no existe ningún biomarcador universalmente aceptado que refleje los cambios del estado de hidratación en respuesta a cambios en la ingesta de bebidas. Objetivo: Hemos llevado a cabo una revisión para determinar los cuestionarios de ingesta de bebidas disponibles en la literatura científica que evalúan la ingesta de bebidas y el estado de hidratación y que han sido validados con biomarcadores de hidratación. Métodos: Se realizó una búsqueda bibliográfica en la literatura científica. Se seleccionaron sólo dos artículos, los cuales contenían dos cuestionarios de ingesta de bebidas diferentes, diseñados para capturar la ingesta habitual de bebidas. Ambos cuestionarios fueron validados con el biomarcador Gravedad específica de la orina (Usg). Resultados: El Cuestionario de Balance Hídrico (WBQ) no reportó correlaciones en el primer estudio y el Cuestionario de Ingesta de Bebidas (BEVQ), que es un cuestionario de frecuencia de consumo alimentario (FFQ) en el segundo estudio, tampoco encontró una correlación positiva. El FFQ parece medir mejor la ingesta de bebidas que el WBQ en comparación con los biomarcadores. Sin embargo, el WBQ parece ser un método más completo para evaluar el balance hídrico de una población dada. Conclusión: Se necesita más investigación para entender el significado de las diferentes correlaciones entre las estimaciones de ingesta y los biomarcadores de bebidas en distintos grupos de población y en diferentes entornos.

  16. Development Status of Optical and Electromagnetic Instruments onboard JEM-GLIMS

    NASA Astrophysics Data System (ADS)

    Sato, Mitsuteru; Ushio, Tomoo; Morimoto, Takeshi; Suzuki, Makoto; Yamazaki, Atsushi; Ishida, Ryohei; Takahashi, Yukihiro; Hobara, Yasuhide; Sakamoto, Yuji; Yoshita, Kengo

    In order to study the generation mechanism of Transient Luminous Events (TLEs), global oc-currence rates and distributions of lightning and TLEs, and the relationship between lightning, TLEs and Terrestrial Gamma-ray Flashes (TGFs), we will carry out the lightning and TLE observation at Exposed Facility of Japanese Experiment Module (JEM-EF) of International Space Station (ISS). In this mission named JEM-GLIMS (Global Lightning and sprIte Mea-surementS on JEM-EF) two kinds of optical instruments and two sets of radio receivers will be integrated into the Multi mission Consolidated Equipment (MCE) which is the bus system and will be installed at JEM-EF. The optical instruments consist of two wide FOV CMOS cameras and six wide FOV photometers, and all these optical instruments are pointed to the nadir direction. CMOS cameras named LSI (Lightning and Sprite Imager) use the STAR-250 device as a detector, which has 512x512 pixels and 25x25 µm pixel size, and have 28.3x28.3 deg. FOV. One CMOS camera with a wide band filter (730-830 nm) mainly measures lightning emission, while another camera with a narrowband filter (766+/-6 nm) mainly measures TLE emission. Five of six photometers named as PH have 42.7 deg. FOV and use photomultiplier tube (PMT) as a photon detector. They equip band-pass filters (150-280 nm, 316+/-5 nm, 337+/-5 nm, 392+/-5 nm, and 762+/-5 nm) for the absolute intensity measurement of the TLE emission. One of six photometers equips a wide-band filter (600-900 nm) to detect light-ning occurring within 86.8 deg. FOV. These output signals will be recorded with the sampling frequency of 20 kHz with a 12-bit resolution. One of two electromagnetic instruments is a VLF receiver (VLFR), which measures electromagnetic waves in the frequency range of 1-40 kHz with 16-bit resolution. Another instrument is VHF interferometer (VITF), which measures VHF pulses generated lightning discharge in the frequency range of 70-100 MHz. JEM-GIMS will be launched in 2011. We

  17. [Carotid body paraganglioma in a teenager. Case report].

    PubMed

    López-Vázquez, María Elisa; Llamas-Macías, Francisco Javier; Nuño-Escobar, César; González-Ojeda, Alejandro; Fuentes-Orozco, Clotilde; Macías-Amezcua, Michel Dassaejv

    2014-01-01

    Antecedentes: los paragangliomas de cabeza y cuello son tumores neuroendocrinos de baja incidencia (0.6%), en su mayor parte benignos, en cuyo origen se han involucrado múltiples factores. Los seres humanos y otras especies que viven a grandes alturas (por arriba de 2000 metros sobre el nivel del mar) son propensos a sufrir hipoxia crónica relativa, hiperplasia del cuerpo carotídeo y, eventualmente, paragangliomas. Este padecimiento aparece en la quinta década de la vida y en la tercera, en caso de presentación familiar. Caso clínico: se comunica el caso de una adolescente de 16 años de edad que un año antes tuvo faringitis aguda con tumor localizado en la cara lateral izquierda del cuello, de crecimiento gradual, sin ningún síntoma. El ultrasonido Doppler dúplex de cuello mostró una lesión nodular sólida sobre el trayecto de la bifurcación carotídea izquierda. Fue intervenida quirúrgicamente mediante cervicotomía lateral izquierda, en la cual se encontró una tumoración de aproximadamente 4 × 3 × 3 cm, sumamente vascularizada, que afectaba la carótida común desde su tercio medio, la carótida interna hasta la base del cráneo y la carótida externa hasta el tercio superior, con íntima relación con la tráquea, el esófago y la columna cervical. La tumoración se resecó en su totalidad, el estudio histopatológico corroboró los paragangliomas. Conclusiones: la edad de presentación es poco común, por lo que se considera relevante y de interés clínico comunicar este caso, toda vez que debe considerarse como posibilidad diagnóstica.

  18. Hydrologic Prediction Through Earthcube Enabled Hydrogeophysical Cyberinfrastructure

    NASA Astrophysics Data System (ADS)

    Versteeg, R. J.; Johnson, D.

    2012-12-01

    Accurate prediction of hydrologic processes is contingent on the successful interaction of multiple components, including (1) accurate conceptual and numerical models describing physical, chemical and biological processes (2) a numerical framework for integration of such processes and (3) multidisciplinary temporal data streams which feeds such models. Over the past ten years the main focus in the hydrogeophysical community has been the advancement and developments of conceptual and numerical models. While this advancement still poses numerous challenges (e.g. the in silico modeling of microbiological processes and the coupling of models across different interfaces) there is now a fairly good high level understanding of the types, scales of and interplay between processes. In parallel with this advancement there have been rapid developments in data acquisition capabilities (ranging from satellite based remote sensing to low cost sensor networks) and the associated cyberinfrastructure which allows for mash ups of data from heterogeneous and independent sensor networks. The tools for this in generally have come from outside the hydrogeophysical community - partly these are specific scientific tools developed through NSF, DOE and NASA funding, and partly these are general web2.0 tools or tools developed under commercial initiatives (e.g. the IBM Smarter Planet initiative). One challenge facing the hydrogeophysical community is how to effectively harness all these tools to develop hydrologic prediction tools. One of the primary opportunities for this is the NSF funded EarthCube effort (http://earthcube.ning.com/ ). The goal of EarthCube is to transform the conduct of research by supporting the development of community-guided cyberinfrastructure to integrate data and information for knowledge management across the Geosciences. Note that Earthcube is part of a larger NSF effort (Cyberinfrastructure for the 21st Century (CIF21), and that Earthcube is driven by the vision

  19. A Study of Energy Management Systems and its Failure Modes in Smart Grid Power Distribution

    NASA Astrophysics Data System (ADS)

    Musani, Aatif

    The subject of this thesis is distribution level load management using a pricing signal in a smart grid infrastructure. The project relates to energy management in a spe-cialized distribution system known as the Future Renewable Electric Energy Delivery and Management (FREEDM) system. Energy management through demand response is one of the key applications of smart grid. Demand response today is envisioned as a method in which the price could be communicated to the consumers and they may shift their loads from high price periods to the low price periods. The development and deployment of the FREEDM system necessitates controls of energy and power at the point of end use. In this thesis, the main objective is to develop the control model of the Energy Management System (EMS). The energy and power management in the FREEDM system is digitally controlled therefore all signals containing system states are discrete. The EMS is modeled as a discrete closed loop transfer function in the z-domain. A breakdown of power and energy control devices such as EMS components may result in energy con-sumption error. This leads to one of the main focuses of the thesis which is to identify and study component failures of the designed control system. Moreover, H-infinity ro-bust control method is applied to ensure effectiveness of the control architecture. A focus of the study is cyber security attack, specifically bad data detection in price. Test cases are used to illustrate the performance of the EMS control design, the effect of failure modes and the application of robust control technique. The EMS was represented by a linear z-domain model. The transfer function be-tween the pricing signal and the demand response was designed and used as a test bed. EMS potential failure modes were identified and studied. Three bad data detection meth-odologies were implemented and a voting policy was used to declare bad data. The run-ning mean and standard deviation analysis method proves to be

  20. The Mediterranean diet and micronutrient levels in depressive patients.

    PubMed

    Ibarra, Olga; Gili, Margalida; Roca, Miguel; Vives, Margalida; Serrano, María Jesús; Pareja, Antonio; García-Campayo, Javier; Gómez-Juanes, Rocío; García-Toro, Mauro

    2014-10-03

    Introducción: Se ha comunicado una correlación inversa entre depresión y el nivel sérico de algunos micronutrientes (selenio, zinc, hierro, magnesio, vitamina B y acido fólico). Además, otros estudios han señalado que la suplementar de estos micronutrientes puede mejorar la depresión. La dieta mediterránea proporciona una suficiente cantidad de los micronutrientes mencionados, aunque ningún estudio ha probado si la prescripción de dicha dieta puede incrementar los niveles de micronutrientes en pacientes depresivos. Objetivo: Examinar el impacto de recomendar un patrón dietético mediterráneo en los niveles de micronutrientes de pacientes deprimidos. Material y Métodos: 77 pacientes ambulatorios se aleatorizaron entre un grupo de intervención (recomendaciones higiénico-dietéticas sobre dieta, ejercicio, sueño y exposición solar) y un grupo control. La evolución fue evaluada antes y después de los seis meses del periodo de intervención. Resultados: Los niveles de selenio y de zinc fueron ligeramente bajos en la determinación basal y el nivel de selenio correlacionaba inversamente con la severidad de la depresión (r=-0.233; p=0.041). El grupo activo evolucionó mejor de la clínica depresiva. Sin embargo, no se observaron diferencias significativas en los niveles de micronutrientes después de la prescripción del patrón de dieta mediterránea probablemente a causa de una insuficiente adherencia. Conclusión: Los niveles séricos de selenio, zinc, hierro, magnesio vitamina B12 y acido fólico no aumentaron en pacientes depresivos seis meses después de prescribir un patrón de dieta mediterránea.

  1. Characterization of W-Ti-O thin films for application in photovoltaics

    NASA Astrophysics Data System (ADS)

    Christmas, Amanda P.

    Photovoltaic (PV) devices consist of the conversion of light energy into electricity. Nearly all PV technologies employ transparent conducting oxides (TCO) as an integral part of the de-vice structure so that the light can reach the semiconductor. The predominant transparent conducting oxide (TCO) that is currently being used in industry is indium tin oxide (ITO). However, Indium (In) is high in cost and becoming scarce in the world. This work is focused towards Titanium doped Tungsten oxide (WO3) for TCO application. The ultimate goal is making novel, cheaper, and efficient TCOs based on W-Ti-O films. Titanium will enhance the conductivity of the film. In addition, Ti is more abundant than In thus leading to low-cost TCO. Ti-doped WO3 (W-Ti-O) films were grown by co-sputter deposition onto silicon, Si (100), and optical grade quartz wafers. Co-sputtering of Ti and W metal targets was per-formed in a wide growth temperature range (room temperature (RT)-500 °C). The Ti sputter-ing power varied from 50 watts-100 watts in order to gain an understanding of the Ti effect. The structure and optical properties were characterized by the X-ray diffraction (XRD), scan-ning electron microscopy (SEM) and the spectrophotometry measurements. The films are op-tically transparent and a correlation between the growth conditions and optical properties is derived. The XRD results show W-Ti-O films grown at RT are amorphous and the films crys-tallize at 200°C. A decrease in the peak intensity implies that the crystallinity decreases with an increase in titanium (Ti) along with a phase change at higher substrate growth tempera-tures. The optical results show the transparency of the films is well above 80%. The energy band gap decreases from 4.0 eV to 3.9 eV with an increase in substrate temperature and in-creases from 3.85 eV to 3.95 eV with an increase of Ti. These results meet the criteria of two essential TCO parameters.

  2. OBESITY PHENOTYPES IN URBAN MIDDLE-CLASS COHORTS; THE PRIT-LINDAVISTA MERGING EVIDENCE IN MEXICO: THE OPUS PRIME STUDY.

    PubMed

    Fanghänel-Salmón, Guillermo; Gutiérrez-Salmeán, Gabriela; Samaniego, Virginia; Meaney, Alejandra; Sánchez-Reyes, Leticia; Navarrete, Ulises; Alcocer, Luis; Olivares-Corichi, Ivonne; Najera, Nayeli; Ceballos, Guillermo; Meaney, Eduardo

    2015-07-01

    Antecedentes y metas: aun cuando el sobrepeso y la obesidad (S/O) son enfermedades reconocidas, hay un reclamo por la existencia de un fenotipo llamado “obeso sano”. Pocos estudios han explorado la presencia de diferentes fenotipos metabólicos en los rangos del índice de masa corporal (IMC) y su asociación con riesgo cardiovascular. Métodos: se determinaron fenotipos de acuerdo al IMC y a la presencia de marcadores del síndrome metabólico (SM) (circunferencia abdominal, presión sanguínea, glucemia en ayunas y perfil de lípidos). El riesgo cardiovascular fue estimado con los índices aterogénicos: colesterol total/HDL-c, LDL-c/HDL-c y triglicéridos(TG)/HDL-c. Resultados: en 8.405 adultos mexicanos, 36% delgados, 43% con sobrepeso y 21% obesos, se identificaron 9 fenotipos. Por cada categoría de peso se encontraron sujetos con metabolismo normal (ningún factor de SM), intermedios (≤ 2) y dismetabólicos (≥ 3). Solo el 10.8% de los sujetos con S/O tuvieron metabolismo normal y el 5.8% de los sujetos delgados fueron dismetabólicos. El riesgo aterogénico fue mayor en los sujetos obesos dismetabólicos. El riesgo fue alto entre todos los sujetos dismetabólicos independientemente del peso. El índice TG/ HDL-c mostró las mismas tendencias. Conclusiones: el riesgo cardiometabólico incrementado deriva de la alta prevalencia de S/O. Una gran proporción de sujetos no obesos tiene dismetabolismo intermedio. Una predisposición genética a la obesidad, la resistencia a la insulina, la diabetes y la dislipidémia en la población mexicana, junto con un estilo de vida no saludable da como consecuencia una epidemia catastrófica de diabetes y enfermedades cardiovasculares.

  3. Variables Measured during Cardiopulmonary Exercise Testing as Predictors of Mortality in Chronic Systolic Heart Failure

    PubMed Central

    Keteyian, Steven J.; Patel, Mahesh; Kraus, William E.; Brawner, Clinton A.; McConnell, Timothy R.; Piña, Ileana L.; Leifer, Eric S.; Fleg, Jerome L.; Blackburn, Gordon; Fonarow, Gregg C.; Chase, Paul J.; Piner, Lucy; Vest, Marianne; O’Connor, Christopher M.; Ehrman, Jonathan K.; Walsh, Mary N.; Ewald, Gregory; Bensimhon, Dan; Russell, Stuart D.

    2015-01-01

    BACKGROUND Data from a cardiopulmonary exercise (CPX) test are used to determine prognosis in patients with chronic heart failure (HF). However, few published studies have simultaneously compared the relative prognostic strength of multiple CPX variables. OBJECTIVES We sought to describe the strength of the association among variables measured during a CPX test and all-cause mortality in patients with HF with reduced ejection fraction (HFrEF), including the influence of sex and patient effort, as measured by respiratory exchange ratio (RER). METHODS Among patients (n = 2,100, 29% women) enrolled in the HF-ACTION (HF-A Controlled Trial Investigating Outcomes of exercise traiNing) trial, 10 CPX test variables measured at baseline (e.g., peak oxygen uptake [VO2], exercise duration, percent predicted peak VO2 [%ppVO2], ventilatory efficiency) were examined. RESULTS Over a median follow-up of 32 months, there were 357 deaths. All CPX variables, except RER, were related to all-cause mortality (all p < 0.0001). Both %ppVO2 and exercise duration were equally able to predict (Wald χ2: ~141) and discriminate (c-index: 0.69) mortality. Peak VO2 (mL·kg−1·min−1) was the strongest predictor of mortality among men (Wald χ2: 129) and exercise duration among women (Wald χ2: 41). Multivariable analyses showed that %ppVO2, exercise duration, and peak VO2 (mL·kg−1·min−1) were similarly able to predict and discriminate mortality. In men, a 10% 1-year mortality rate corresponded to a peak VO2 of 10.9 mL·kg−1·min−1 versus 5.3 mlkg−1/min−1 in women. CONCLUSIONS Peak VO2, exercise duration, and % ppVO2 carried the strongest ability to predict and discriminate the likelihood of death in patients with HFrEF. The prognosis associated with a given peak V2 differed by sex. PMID:26892413

  4. Magnetotelluric investigation of the geothermal anomaly in Hailin, Mudanjiang, northeastern China

    NASA Astrophysics Data System (ADS)

    Zhang, Lili; Hao, Tianyao; Xiao, Qibin; Wang, Jie; Zhou, Liang; Qi, Min; Cui, Xiangpan; Cai, Ningxiao

    2015-07-01

    To study the occurrence conditions and locations of geothermal bodies in Hailin, Mudanjiang, northeastern China, we conducted a magnetotelluric investigation to delineate the electrical conductivity structure of the area on three parallel profiles. The area to the west of the Mudanjiang Fault lies in the Hailang sag of the Ning'an Basin. The data were processed using the mutual reference technique, static shift correction, and structural strike and dimensionality analysis based on tensor decomposition. Moreover, a modified anisotropic-diffusion-based method was used to suppress noise for the magnetotelluric time series data. This method retains the advantages of conventional anisotropic diffusion and is superior in its discrimination ability. The method is characteristic not only of the inherited features such as intra-region smoothing and edge preservation, but also of the adaptive selection of the diffusion coefficient. Data analysis revealed that the electrical resistivity structure can be approximated by a two-dimensional characterization. Two-dimensional inversion and rendering visualization show that a highly resistive granite basement is covered with conductive sedimentary layers and that a relatively low-resistivity anomalous structure with a resistivity of approximately 100-600 Ω·m is imbedded in the high-resistivity background. The anomalous structure has a narrow top and a wide bottom (the bottom depth is at least 3500 m). The shape and electrical features of the structure indicate favorable storage space for hot subsurface water. Fault activities and magma intrusion may result in the fractures of the basement, which are filled with hot water and thus produce the relatively low resistivity. Based on a comprehensive analysis, we infer that the structure is indicative of a geothermal reservoir. An exploratory well drilled near the structure confirms the occurrence of high temperatures. Several geological factors (cap rock, basement, and major faults

  5. An Optical Lightning Simulator in an Electrified Cloud-Resolving Model to Prepare the Future Space Lightning Missions

    NASA Astrophysics Data System (ADS)

    Bovalo, Christophe; Defer, Eric; Pinty, Jean-Pierre

    2016-04-01

    The future decade will see the launch of several space missions designed to monitor the total lightning activity. Among these missions, the American (Geostationary Lightning Mapper - GLM) and European (Lightning Imager - LI) optical detectors will be onboard geostationary satellites (GOES-R and MTG, respectively). For the first time, the total lightning activity will be monitored over the full Earth disk and at a very high temporal resolution (2 and 1 ms, respectively). Missions like the French Tool for the Analysis of Radiation from lightNIng and Sprites (TARANIS) and ISS-LIS will bring complementary information in order to better understand the lightning physics and to improve the weather prediction (nowcasting and forecasting). Such missions will generate a huge volume of new and original observations for the scientific community and weather prediction centers that have to be prepared. Moreover, before the launch of these missions, fundamental questions regarding the interpretation of the optical signal property and its relation to cloud optical thickness and lightning discharge processes need to be further investigated. An innovative approach proposed here is to use the synergy existing in the French MesoNH Cloud-Resolving Model (CRM). Indeed, MesoNH is one of the only CRM able to simulate the lifecycle of electrical charges generated within clouds through non-inductive charging process (dependent of the 1-moment microphysical scheme). The lightning flash geometry is based on a fractal law while the electrical field is diagnosed thanks to the Gauss' law. The lightning optical simulator is linked to the electrical scheme as the lightning radiance at 777.4 nm is a function of the lightning current, approximated by the charges neutralized along the lightning path. Another important part is the scattering of this signal by the hydrometeors (mainly ice particles) that is taken into account. Simulations at 1-km resolution are done over the Langmuir Laboratory (New

  6. A Governance Roadmap and Framework for EarthCube

    NASA Astrophysics Data System (ADS)

    Governance Steering Committee, EarthCube

    2013-04-01

    more effectively, by providing a community endorsed Governance Framework, released in September of 2012. The Framework, and corresponding community outreach, maximizes engagement of the broader EarthCube community, which in turn minimizes the risks that the community will not adopt EarthCube in its development and final states. The target stakeholder community includes academia, government, and the private-sector, both nationally and internationally. http://earthcube.ning.com/group/governance

  7. The Operational Role of the Belgian User Support and Operations Centre for the Atmosphere-Space Interactions Monitor (ASIM) on-board the International Space Station.

    NASA Astrophysics Data System (ADS)

    Muller, C.; Moreau, D., Sr.; Pandey, P. K.; Crosby, N. B.

    2014-12-01

    The Belgian User Support and Operations Centre (B.USOC) is an operational centre managing technological and scientific payloads on the International Space Station (ISS). B.USOC is the Facility Responsible Centre (FRC) for the European Space Agency's (ESA) Atmosphere-Space Interactions Monitor (ASIM) payload and also manages the Scientific Mission Centre of the Centre National d'Etudes Spatiales (CNES) PICARD satellite that monitors solar activity, among various other space missions. In this respect, B.USOC is ideally positioned to manage possible synergies between ASIM, the satellite TARANIS (Tool for the Analysis of RAdiation from lightNIng and Sprites), other space missions and ground-based networks. The ASIM mission (Neubert, 2009) consists of a package of two nadir instruments: one for the visible spectrum and another for X-ray and gamma-ray frequencies. In the normal operating mode "trigger mode" both instruments continuously measure, but, do not record data below certain thresholds. Another mode is a "timed mode", where, during a certain time the observations are recorded even in the absence of triggers. The "timed mode" demands a lot of flexibility from both scientific teams and B.USOC, as, ASIM's main targets of investigation (sprites and elves) are related to intense thunderstorms and thus, require reliable meteorological forecasts in the entire range of ISS latitudes. Moreover, ASIM is sensitive to a large number of phenomena of which most have a direct relationship with solar activity and therefore would probably need support from the ESA SSA (Space Situational Awareness) Space Weather Coordination Centre (SSCC) that shares the same campus with B.USOC. Local cooperation between the two centres, together with other space payloads such as TARANIS and ground-based networks will greatly optimize ASIM payload operations as well as scientific return. Neubert, T., and the ASIM Team, ASIM - an Instrument Suite for the International Space Station, Corte Workshop

  8. Cirugía transnasal endoscópica para tumores de hipófisis

    PubMed Central

    Ajler, Pablo; Hem, Santiago; Goldschmidt, Ezequiel; Landriel, Federico; Campero, Alvaro; Yampolsky, Claudio; Carrizo, Antonio

    2012-01-01

    Introducción: Exponer la técnica utilizada y los resultados obtenidos en los primeros 52 pacientes portadores de tumores hipofisarios tratados por la vía endoscópica transnasal en el Hospital Italiano de Buenos Aires Métodos: Se llevó a cabo un análisis retrospectivo de 52 cirugías endoscópicas transnasales utilizadas en el tratamiento de tumores hipofisários. Las mismas fueron realizadas en el Hospital Italiano de Buenos Aires durante el período junio del 2011 a junio del 2012. Se analizaron las características demográficas de los pacientes, la patología de base y la morbimortalidad asociada a la cirugía. Resultados: La edad media de los pacientes fue de 41,52 años con un rango de 18-79. La distribución fue similar entre hombres y mujeres. Las patologías más frecuentes fueron: adenomas no funcionantes (40.4%), tumores productores de GH/Acromegalia (25%) y tumores productores de ACTH/Enfermedad de Cushing (23.1%). Aproximadamente el 70 % correspondieron a macroadenomas. Sólo un paciente presentó complicaciones. No se registro ningún óbito. Conclusión: Si bien podremos objetivar fehacientemente resultados más concluyentes en futuros trabajos, podemos decir a priori que, en la endoscopía el detalle anatómico es claramente superior al microscópico y que la posibilidad de la introducción del endoscopio en la silla turca permite la visualización directa de remanentes tumorales, de sitios de fístula y como así también de la glándula normal, ventajas que potencialmente podrían permitir obtener mejores resultados quirúrgicos, en términos de control de la enfermedad y tasa de complicaciones. PMID:23596553

  9. L'encéphalomyélite aiguë disséminée chez l'enfant

    PubMed Central

    Tadmori, Ilham; Chaouki, Sana; Abourazzak, Sana; Zahra, Souilmi Fatima; Benmiloud, Sarra; Idrissi, Mounia Lakhdar; Atmani, Samir; Hida, Moustapha

    2014-01-01

    L'encéphalomyélite aiguë disséminée (ADEM) est une maladie inflammatoire, démyélinisante, multifocale intéressant principalement la substance blanche du système nerveux central. Elle est rare mais non exceptionnelle chez l'enfant. Les auteurs rapportent une étude colligeant 9 cas d'ADEM pris en charge au service de Pédiatrie du CHU Hassan II à Fès, sur une période de 4 ans. Il s'agit de cinq garçons et quatre filles; âgés entre 2 ans et 13 ans. Les antécédents (ATCD) d'infection virale sont notés chez quatre patients. La fièvre est constante. Les convulsions sont présentes dans cinq cas et les troubles de conscience dans cinq cas. L'examen neurologique était anormal. L’étude de liquide céphalo-rachidien a révélé une réaction méningée. On ne notait pas de syndrome inflammatoire biologique. L'imagerie par résonance magnétique (IRM) cérébrale a objectivé des lésions en hyper-signal en T2 et T2 FLAIR chez tous les patients. Pour le traitement, des bolus de corticoïdes intraveineux ont été administrés, relayés par une corticothérapie orale et associés à une kinésithérapie motrice et un traitement antiépileptique pour certains patients. L’évolution de nos malades était favorable globalement et on a déploré le décès d'une patiente. L'ADEM est une affection rare du système nerveux central. Les critères diagnostiques sont fondés sur des éléments cliniques et des données d'imagerie. La prise en charge doit être précoce et multidisciplinaire. PMID:25870735

  10. [Not Available].

    PubMed

    Corella Aznar, Elena Guadalupe; Ayerza Casas, Ariadna; Samper Villagrasa, Pilar; Rodríguez Vigil, Carmen; Jiménez Montañés, Lorenzo; Calvo Escribano, Carlota; Labarta Aizpun, José Ignacio

    2016-06-30

    Introducción: los supervivientes de leucemia aguda (LA) infantil presentan un riesgo incrementado de alteraciones metabólicas y cardiovasculares que aumentan su morbimortalidad a largo plazo.Objetivo: estimar la prevalencia de obesidad, resistencia a la insulina, dislipemia e hipertensión arterial como factores de riesgo cardiometabólico (FRCM) en un grupo de supervivientes de LA infantil, y analizar las posibles causas asociadas a su desarrollo.Material y métodos: estudio observacional retrospectivo en 47 supervivientes de LA tratados en un periodo de 4 años, que recibieron seguimiento durante 10 años.Resultados: el 40% de los participantes presentaron al menos un FRCM durante el seguimiento, siendo la dislipemia (aumento LDL) el más frecuente (38,3%), seguido de obesidad/sobrepeso (31,9%) y HTA sistólica (23,4%). El sexo femenino se estableció como factor de riesgo parael desarrollo de todos ellos (RR 1,6; RR 3,16; RR 1,69; p < 0,05). Ningún superviviente desarrolló diabetes mellitus, pero sí resistencia a la insulina el 19,4%. Los pacientes con leucemias de peor pronóstico presentaron mayor riesgo de desarrollar obesidad, resistencia a la insulina y aumento de LDL (RR 3,56; RR 4,08; RR 2,53; p < 0,05). Los pacientes tratados con trasplante de progenitores hematopoyéticos presentaron mayor riesgo de obesidad, aumento de LDL e HTA sistólica (RR 2,86; RR 2,39; RR 3,12; p<0,05). La radioterapia se asoció de igual modo con un incremento de resistencia a la insulina e hipertensión arterial sistólica (RR 2,47; RR 2,53; p < 0,05).Conclusiones: existe un aumento en la prevalencia de obesidad/sobrepeso, dislipemia, resistencia a la insulina y alteración de la tensión arterial sistólica en supervivientes de leucemia aguda infantil a lo largo del tiempo, especialmente en aquellos con enfermedades y tratamientos más agresivos.

  11. Un accident vasculaire hémorragique révélant une méningite à Neisseria meningitides

    PubMed Central

    Savadogo, Mamoudou; Millogo, Georges Rosario Christian; Zabsonré, Sylvain

    2015-01-01

    L'accident vasculaire hémorragique et la méningite purulente constituent des urgences médicales chez la personne âgée. L'Objectif est de rapporter un cas d'accident vasculaire hémorragique associé à une méningite purulente à Neisseria meningitidis survenus chez une personne âgée. Il s'agit d'une patiente de 62 ans sans antécédent pathologique connu, a été admise aux urgences médicales du CHU YO pour céphalées + vomissement et notion de perte brutale de connaissance. L'examen à son admission notait un syndrome infectieux, une conscience obnubilée sans déficit moteur, une raideur cervicale et une hypertension artérielle. La tomodensitométrie cérébrale avait objectivé une hémorragie méningée diffuse avec inondation du 4ème ventricule responsable d'une hydrocéphalie triventriculairesous jacente d'allure obstructive associée à des sinusites ethmoïdo-sphénoïdales droites chroniques. Une ponction lombaire réalisée avait montré un liquide cérébrospinal citrin dont l'analyse était en faveur d'une méningite purulente à méningocoque. La glycémie était élevée à 15,8 mmol/l et l'hémoglobine glyquée était égale à 7,7%. L’évolution a été favorable sous traitement à base de ceftriaxone et de Metformine. Devant un cas suspect de méningite chez une personne âgée, la ponction lombaire après un TDM cérébral permet de poser le diagnostic et d'entreprendre rapidement une antibiothérapie indispensable pour la prévention des complications. PMID:26097638

  12. LLE Review 83, Quarterly Report

    SciTech Connect

    2000-12-01

    This volume of the LLE Review, covering April-June 2000, features an article by F. J. Marshall, T. Ohki, D. McInnis, Z. Ninkov, and J. Carbone, who detail the conversion of the OMEGA time-integrated x-ray diagnostics to electronic readout using direct-detection x-ray cameras [charge-injection devices (CID's)]. Pinhole and x-ray microscope images are shown along with inferred calibration measurements of the CID cameras. Currently, the same cameras are being used to obtain x-ray spectra in a TIM-based spectrometer, extending their use to all time-integrated imaging and spectroscopic x-ray instruments used on OMEGA. Additional highlights of the research presented in this issue are: (1) V. A. Smalyuk, B. Yaakobi, F. J. Marshall, and D. D. Meyerhofer investigate the spatial structure of the temperature and density of target-shell plasmas at peak compression (stagnation). This is accomplished by examining the energy dependence of the x-ray emission using narrow-band x-ray filters and the known absorption properties of the shell dopant (Ti). (2) F. Sequin, C. K. Ll, D. G. Hicks, J. A. Frenje, K. M. Green, R. D. Petrasso, J. M. Soures, V. Yu. Glebov, C. Stoeckl, P. B. Radha, D. D. Meyerhofer, S. Roberts, C. Sorce, T. C. Sangster, M. D. Cable, S. Padalino, and K. Fletcher detail the physics and instrumentation used to obtain and interpret secondary D-{sup 3}He proton spectra from current gas-filled-target and future cryogenic-target experiments. Through a novel extension of existing charged-particle detection techniques with track detectors, the authors demonstrate the ability to obtain secondary proton spectra with increased sensitivity. (3) M. Guardelben, L. Ning, N. Jain, D. Battaglia, and K. Marshall compare the utility of a novel liquid-crystal-based, point-diffraction interferometer (LCPDI) with the commercial standard phase-shifting interferometer and conclude that the LCPDI is a viable low-cost alternative. (4) A. B. Shorey, S. D. Jacobs, W. I. Kordonski, and R. F

  13. Sun-Earth Day: Reaching the Education Audience by Informal Means

    NASA Technical Reports Server (NTRS)

    Thieman, J.; Lewis, E.; Cline, T.

    2010-01-01

    For ten years the Sun-Earth Day program has promoted Heliophysics education to ever larger audiences through events centered on attractive annual themes. What originally started out as a one day event quickly evolved into a series of programs and events that occur throughout the year culminating with a celebration on or near the Spring Equinox. The events are often formal broadcasts or webcasts seeking to convey the science behind the latest solar-terrestrial mission discoveries. This has been quite successful, but it is clear that the younger generation increasingly depends on social networking approaches and informal news transmission for learning what is happening in the world around them. For 2010, the Sun-Earth Day team put emphasis on using informal approaches to bring the theme to the audience. The main event, a webcast from the NASA booth at the National Science Teachers Association (NSTA) annual meeting by the NASA EDGE group, took a lighthearted and offbeat approach to interviewing scientists and educators about Heliophysics news. NASA EDGE programs are unscripted and unpredictable, and that represents a different approach to getting the message across. The webcast was supplemented by a number of social networking avenues. The Sun-Earth Day program explored a wide range of social media applications including Facebook, Twitter, NING, podcasting, iPhone apps, etc. Each of these offers unique and effective methods to promote Heliophysics content and mission related highlights. The facebook site was quite popular and message posting there told the Sun-Earth Day story piece by piece. The same could be said of twittering and the tweetup held at the NSTA site. Has all of this been effective? Results are still being gathered, but anecdotal responses from the world seem very positive. What other methods might be used in the future to bring the science to a personal hands-on, interactive experience? Outcomes: Participants will: (1) Be introduced to the Sun

  14. Effect of zinc supplementation on superoxide dismutase activity in patients with ulcerative rectocolitis.

    PubMed

    Paz Matias, Juliana; Costa e Silva, Danilla Michelle; Clímaco Cruz, Kyria Jayanne; Gomes da Silva, Kelcylene; Monte Feitosa, Mayara; Oliveira Medeiros, Leydiane Gleici; do Nascimento Marreiro, Dilina; do Nascimento Nogueira, Nadir

    2014-12-17

    Introducción: La colitis ulcerosa se caracteriza por la inflamación difusa de la mucosa y el estrés oxidativo. De esta forma, el cuerpo activa el sistema de defensa antioxidante en un intento de reducir la producción excesiva de especies reactivas de oxígeno, así como poder neutralizarlos. Objetivo: Este estudio evaluó el efecto de la suplementación de zinc sobre la actividad de la enzima superóxido dismutasa en pacientes con colitis ulcerosa. Métodos: El estudio incluyó 24 pacientes, con edades comprendidas entre 20 y 59 años y con diagnóstico de colitis ulcerosa en fase de remisión de la enfermedad. Los pacientes fueron divididos en dos grupos: experimental - deficiencia de zinc (n = 12) y control - normales o con altos contenido de zinc (n = 12). El grupo experimental se sometió a tratamiento con suplemento de drogas, en forma de gluconato de zinc (30 mg Zn / día), administrada diariamente por la mañana en ayunas durante 60 días. Las concentraciones en plasma y los eritrocitos de zinc se determinaron por espectrofotometría de absorción atómica de llama. La actividad de la superóxido dismutasa (SOD) se determinó por el método de eritrocitos in vitro utilizando el kit de Randox. Resultados y Discusión: La suplementación de zinc causó un aumento significativo en las concentraciones plasmáticas de mineral y mostró una reducción significativa en los eritrocitos, permaneciendo dentro de los límites normales. La actividad de SOD fue mayor en los pacientes de los grupos experimentales y de control, sin diferencias después de la suplementación. Conclusión: El estudio evidenció que la administración de suplementos de zinc mejora la condición homeostática del mineral, sin ningún cambio en la actividad de SOD, como un marcador de estrés oxidativo en pacientes con colitis ulcerosa.

  15. Low-frequency variability of the Atlantic MOC in the eddying regime : the intrinsic component.

    NASA Astrophysics Data System (ADS)

    Gregorio, S.; Penduff, T.; Barnier, B.; Molines, J.-M.; Le Sommer, J.

    2012-04-01

    A 327-year 1/4° global ocean/sea-ice simulation has been produced by the DRAKKAR ocean modeling consortium. This simulation is forced by a repeated seasonal atmospheric forcing but nevertheless exhibits a substantial low-frequency variability (at interannual and longer timescales), which is therefore of intrinsic origin. This nonlinearly-generated intrinsic variability is almost absent from the coarse-resolution (2°) version of this simulation. Comparing the 1/4° simulation with its fully-forced counterpart, Penduff et al. (2011) have shown that the low-frequency variability of local sea-level is largely generated by the ocean itself in eddying areas, rather than directly forced by the atmosphere. Using the same simulations, the present study quantifies the imprint of the intrinsic low-frequency variability on the Meridional Overturning Circulation (MOC) at interannual-to-decadal timescales in the Atlantic. We first compare the intrinsic and atmospherically-forced interannual variances of the Atlantic MOC calculated in geopotential coordinates. This analysis reveals substantial sources of intrinsic MOC variability in the South Atlantic (driven by the Agulhas mesoscale activity according to Biastoch et al. (2008)), but also in the North Atlantic. We extend our investigation to the MOC calculated in isopycnal coordinates, and identify regions in the basin where the water mass transformation exhibits low-frequency intrinsic variability. In this eddy-permitting regime, intrinsic processes are shown to generate about half the total (geopotential and isopycnal) MOC interannual variance in certain key regions of the Atlantic. This intrinsic variability is absent from 2° simulations. Penduff, T., Juza, M., Barnier, B., Zika, J., Dewar, W.K., Treguier, A.-M., Molines, J.-M., Audiffren, N., 2011: Sea-level expression of intrinsic and forced ocean variabilities at interannual time scales. J. Climate, 24, 5652-5670. doi: 10.1175/JCLI-D-11-00077.1. Biastoch, A., Böning, C

  16. [Update of the stability of drugs cytostatic drugs by applying the methodology of the matrix of risk for the manufacture of sterile drugs].

    PubMed

    Usarralde-Pérez, Ángela; Toro-Chico, Piedad; Pérez-Encinas, Montserrat

    2016-06-01

    Objetivo: Establecer unos plazos de validez de los viales abiertos y/o reconstituidos y de las mezclas citostáticas según su estabilidad fisicoquímica, el nivel de riesgo y los requisitos de preparación asignados por la matriz de riesgo de la Guía de Buenas Prácticas de Preparación de Medicamentos en los Servicios de Farmacia Hospitalaria. Método: Se elaboró una tabla de estabilidades con los medicamentos citostáticos. Los datos de estabilidad fisicoquímica se obtuvieron de fichas técnicas y revisiones bibliográficas. El nivel de riesgo fue asignado por la matriz de riesgo en función de los requisitos de cada preparación. Cuando la estabilidad fisicoquímica era igual o superior a la indicada por la matriz, se asumieron los plazos de validez de la matriz; en caso contrario, los plazos de validez coincidieron con el periodo máximo de estabilidad fisicoquímica. Resultados: Se revisaron 61 fármacos. Se asumió el plazo de validez físico-química en el 45,9% de los viales abiertos/ reconstituidos y en el 50,8% de las mezclas citostáticas, y el indicado por la matriz de riesgo en el resto, respectivamente. Según la matriz, el nivel de riesgo fue medio en todos los medicamentos citostáticos salvo en uno, que resultó de riesgo alto. Ningún medicamento resultó de riesgo bajo. Conclusiones: Para asignar el plazo de validez de los viales abiertos/reconstituidos y de las mezclas citostáticas no solo es necesario tener en cuenta los datos de estabilidad físico-química, sino también el nivel de riesgo y los requisitos de preparación, permitiendo unos plazos de validez más adecuados.

  17. Nonadherence with Employer-Mandated Sleep Apnea Treatment and Increased Risk of Serious Truck Crashes

    PubMed Central

    Burks, Stephen V.; Anderson, Jon E.; Bombyk, Matthew; Haider, Rebecca; Ganzhorn, Derek; Jiao, Xueyang; Lewis, Connor; Lexvold, Andrew; Liu, Hong; Ning, Jiachen; Toll, Alice; Hickman, Jeffrey S.; Mabry, Erin; Berger, Mark; Malhotra, Atul; Czeisler, Charles A.; Kales, Stefanos N.

    2016-01-01

    private. Commentary: A commentary on this article appears in this issue on page 961. Citation: Burks SV, Anderson JE, Bombyk M, Haider R, Ganzhorn D, Jiao X, Lewis C, Lexvold A, Liu H, Ning J, Toll A, Hickman JS, Mabry E, Berger M, Malhotra A, Czeisler CA, Kales SN. Nonadherence with employer-mandated sleep apnea treatment and increased risk of serious truck crashes. SLEEP 2016;39(5):967–975. PMID:27070139

  18. [Medicines reconciliation at hospital admission into an electronic prescribing program].

    PubMed

    Villamayor-Blanco, Lucía; Herrero-Poch, Leticia; De-Miguel-Bouzas, Jose Carlos; Freire Vazquez, M Carmen

    2016-09-01

    Objetivo: Describir y analizar los resultados obtenidos durante un año con un nuevo procedimiento de conciliación de la medicación al ingreso hospitalario basado en un programa de prescripción electrónica asistida. Método: Estudio observacional, prospectivo, no aleatorizado y no controlado de 12 meses de duración, en el que se incluyeron todos los pacientes que ingresaron, durante ese año, en un hospital general concertado de 450 camas. Para la conciliación de la medicación se utilizó el programa de prescripción electrónica como medio para el abordaje multidisciplinar (enfermería, médicos y farmacéuticos). La conciliación se realizó al ingreso hospitalario y se midieron los errores de conciliación. Resultados: Se incluyeron 23.701 pacientes, conciliándose 53.920 medicamentos, de los cuales no tenían discrepancias 48.744 (90,4%) y 5.176 (9,6%) presentaban discrepancias: 4.731 (8,8 % de los fármacos) justificadas y 445 (0,8% de los fármacos) no justificadas. La mayor parte de las discrepancias no justificadas, (n = 310; 69,7%) se debieron a errores en el registro de la medicación domiciliaria al ingreso: medicación no registrada o errores de medicamentos, dosis, frecuencia o vía de administración, omisiones de prescripción, 23,6% (n = 105) y duplicidades, 6,7% (n = 30). En ningún caso el error de conciliación llegó al paciente. Conclusiones: Mediante las ayudas informáticas incluidas en el programa de prescripción electrónica asistida y el abordaje multidisciplinar del proceso de conciliación se consigue realizar la conciliación de la medicación al ingreso en el 98% de los pacientes en el momento del ingreso, evidenciando errores de conciliación solo en el 1,3% de los pacientes.

  19. A vision for, and progress towards EarthCube

    NASA Astrophysics Data System (ADS)

    Jacobs, C.

    2012-04-01

    range of geosciences data collections and collectors, establish sustainable partnerships with other entities that collect data (e.g. other Federal and international agencies), the integrate simulations and observations, and foster symbiotic relationships with industry. Two realize this vision, NSF posted open letters to the community, had several WebEx session, established a social network website to stimulate community dialog (EarthCube.ning.com), held a Charrette with broad community participation, and is accepting expression of interests from the community for the early development efforts of all or part the EarthCube framework.

  20. Learning from concurrent Lightning Imaging Sensor and Lightning Mapping Array observations in preparation for the MTG-LI mission

    NASA Astrophysics Data System (ADS)

    Defer, Eric; Bovalo, Christophe; Coquillat, Sylvain; Pinty, Jean-Pierre; Farges, Thomas; Krehbiel, Paul; Rison, William

    2016-04-01

    The upcoming decade will see the deployment and the operation of French, European and American space-based missions dedicated to the detection and the characterization of the lightning activity on Earth. For instance the Tool for the Analysis of Radiation from lightNIng and Sprites (TARANIS) mission, with an expected launch in 2018, is a CNES mission dedicated to the study of impulsive energy transfers between the atmosphere of the Earth and the space environment. It will carry a package of Micro Cameras and Photometers (MCP) to detect and locate lightning flashes and triggered Transient Luminous Events (TLEs). At the European level, the Meteosat Third Generation Imager (MTG-I) satellites will carry in 2019 the Lightning Imager (LI) aimed at detecting and locating the lightning activity over almost the full disk of Earth as usually observed with Meteosat geostationary infrared/visible imagers. The American community plans to operate a similar instrument on the GOES-R mission for an effective operation in early 2016. In addition NASA will install in 2016 on the International Space Station the spare version of the Lightning Imaging Sensor (LIS) that has proved its capability to optically detect the tropical lightning activity from the Tropical Rainfall Measuring Mission (TRMM) spacecraft. We will present concurrent observations recorded by the optical space-borne Lightning Imaging Sensor (LIS) and the ground-based Very High Frequency (VHF) Lightning Mapping Array (LMA) for different types of lightning flashes. The properties of the cloud environment will also be considered in the analysis thanks to coincident observations of the different TRMM cloud sensors. The characteristics of the optical signal will be discussed according to the nature of the parent flash components and the cloud properties. This study should provide some insights not only on the expected optical signal that will be recorded by LI, but also on the definition of the validation strategy of LI, and

  1. cAMP and in vivo hypoxia induce tob, ifr1, and fos expression in erythroid cells of the chick embryo.

    PubMed

    Dragon, Stefanie; Offenhäuser, Nina; Baumann, Rosemarie

    2002-04-01

    During avian embryonic development, terminal erythroid differentiation occurs in the circulation. Some of the key events, such as the induction of erythroid 2,3-bisphosphoglycerate (2,3-BPG), carbonic anhydrase (CAII), and pyrimidine 5'-nucleotidase (P5N) synthesis are oxygen dependent (Baumann R, Haller EA, Schöning U, and Weber M, Dev Biol 116: 548-551, 1986; Dragon S and Baumann R, Am J Physiol Regulatory Integrative Comp Physiol 280: R870-R878, 2001; Dragon S, Carey C, Martin K, and Baumann R, J Exp Biol 202: 2787-2795, 1999; Dragon S, Glombitza S, Götz R, and Baumann R, Am J Physiol Regulatory Integrative Comp Physiol 271: R982-R989, 1996; Dragon S, Hille R, Götz R, and Baumann R, Blood 91: 3052-3058, 1998; Million D, Zillner P, and Baumann R, Am J Physiol Regulatory Integrative Comp Physiol 261: R1188-R1196, 1991) in an indirect way: hypoxia stimulates the release of norepinephrine (NE)/adenosine into the circulation (Dragon et al., J Exp Biol 202: 2787-2795, 1999; Dragon et al., Am J Physiol Regulatory Integrative Comp Physiol 271: R982-R989, 1996). This leads via erythroid beta-adrenergic/adenosine A(2) receptor activation to a cAMP signal inducing several proteins in a transcription-dependent manner (Dragon et al., Am J Physiol Regulatory Integrative Comp Physiol 271: R982-R989, 1996; Dragon et al., Blood 91: 3052-3058, 1998; Glombitza S, Dragon S, Berghammer M, Pannermayr M, and Baumann R, Am J Physiol Regulatory Integrative Comp Physiol 271: R973-R981, 1996). To understand how the cAMP-dependent processes are initiated, we screened an erythroid cDNA library for cAMP-regulated genes. We detected three genes that were strongly upregulated (>5-fold) by cAMP in definitive and primitive red blood cells. They are homologous to the mammalian Tob, Ifr1, and Fos proteins. In addition, the genes are induced in the intact embryo during short-term hypoxia. Because the genes are regulators of proliferation and differentiation in other cell types, we suggest that c

  2. Migration and spawning of radio-tagged zulega Prochilodus argenteus in a dammed Brazilian river

    USGS Publications Warehouse

    Godinho, Alexandre L.; Kynard, B.

    2006-01-01

    It is difficult for agencies to evaluate the impacts of the many planned dams on Sa??o Francisco River, Brazil, migratory fishes because fish migrations are poorly known. We conducted a study on zulega Prochilodus argenteus, an important commercial and recreational fish in the Sa??o Francisco River, to identify migrations and spawning areas and to determine linear home range. During two spawning seasons (2001-2003), we radio-tagged fish in three main-stem reaches downstream of Tre??s Marias Dam (TMD), located at river kilometer (rkm) 2,109. We tagged 10 fish at Tre??s Marias (TM), which is 5 km downstream of TMD; 12 fish at Pontal, which is 28 km downstream of TMD and which includes the mouth of the Abaete?? River, and 10 fish at Cilga, which is 45 km downstream of TMD. Late-stage (ripe) adults tagged in each area during the spawning season remained at or near the tagging site, except for four Cilga fish that went to Pontal and probably spawned. The Pontal area at the Abaete?? River mouth was the most important spawning site we found. Prespawning fish moved back and forth between main-stem staging areas upstream of the Abaete?? River mouth and Pontal for short visits. These multiple visits were probably needed as ripe fish waited for spawning cues from a flooding Abaete?? River. Some fish homed to prespaw ning staging areas, spawning areas, and nonspawning areas. The migratory style of zulega was dualistic, with resident and migratory fish. Total linear home range was also dualistic, with small (<26-km) and large (53-127-km) ranges. The locations of spawning areas and home ranges suggest that the Pontal group (which includes Cilga fish) is one population that occupies about 110 km. The Pontal population overlaps a short distance with a population located downstream of Cilga. Movements of late-stage TM adults suggest that the TM group is a separate population, possibly with connections to populations upstream of TMD. ?? Copyright by the American Fisheries Society

  3. Rayleigh-wave phase-velocity maps and three-dimensional shear velocity structure of the western US from local non-plane surface wave tomography

    USGS Publications Warehouse

    Pollitz, F.F.; Snoke, J. Arthur

    2010-01-01

    We utilize two-and-three-quarter years of vertical-component recordings made by the Transportable Array (TA) component of Earthscope to constrain three-dimensional (3-D) seismic shear wave velocity structure in the upper 200 km of the western United States. Single-taper spectral estimation is used to compile measurements of complex spectral amplitudes from 44 317 seismograms generated by 123 teleseismic events. In the first step employed to determine the Rayleigh-wave phase-velocity structure, we implement a new tomographic method, which is simpler and more robust than scattering-based methods (e.g. multi-plane surface wave tomography). The TA is effectively implemented as a large number of local arrays by defining a horizontal Gaussian smoothing distance that weights observations near a given target point. The complex spectral-amplitude measurements are interpreted with the spherical Helmholtz equation using local observations about a succession of target points, resulting in Rayleigh-wave phase-velocity maps at periods over the range of 18–125 s. The derived maps depend on the form of local fits to the Helmholtz equation, which generally involve the nonplane-wave solutions of Friederich et al. In a second step, the phase-velocity maps are used to derive 3-D shear velocity structure. The 3-D velocity images confirm details witnessed in prior body-wave and surface-wave studies and reveal new structures, including a deep (>100 km deep) high-velocity lineament, of width ∼200 km, stretching from the southern Great Valley to northern Utah that may be a relic of plate subduction or, alternatively, either a remnant of the Mojave Precambrian Province or a mantle downwelling. Mantle seismic velocity is highly correlated with heat flow, Holocene volcanism, elastic plate thickness and seismicity. This suggests that shallow mantle structure provides the heat source for associated magmatism, as well as thinning of the thermal lithosphere, leading to relatively high

  4. [TOXIC RISK ASSESSMENT OF FLUORIDE PRESENCE IN BOTTLED WATER CONSUMPTION IN THE CANARY ISLANDS].

    PubMed

    Jáudenes Marrero, Juan Ramón; Hardisson de la Torre, Arturo; Gutiérrez Fernández, Angel José; Rubio Armendáriz, Carmen; Revert Gironés, Consuelo

    2015-11-01

    Introducción: el flúor, como hormetina, es necesario en el organismo para evitar las caries, pero en cantidades excesivas puede llevar a efectos tóxicos adversos como la fluorosis dental o la fluorosis invalidante. Así, será importante no sobrepasar de forma crónica las IDR (Ingestas Diarias Recomendadas) para cada rango de edad y sexo. Se asume que la principal fuente de aporte de fluoruros es el agua. Objetivos: establecer las concentraciones de fluoruro en determinadas marcas de agua envasada que se consumen en Canarias, para renovar los datos ya desactualizados, y hacer la correspondiente evaluación del riesgo tóxico. Método: se han utilizado 25 muestras de siete marcas registradas y comercializadas diferentes, siendo analizadas mediante determinación potenciométrica con electrodo ion selectivo de fluoruro. Resultados: todas las marcas de agua analizadas cumplen con los criterios de calidad según la legislación actual española, ninguna puede considerarse “agua fluorada” y todas se pueden usar en la preparación de alimentos infantiles. Además, según las ingestas diarias de agua recomendadas por la EFSA para cada rango de edad, no se supera la IDR para ningún individuo mayor de cuatro años ni para ninguna de las marcas de agua analizadas. Conclusiones: las aguas envasadas producidas en Canarias tienen niveles de fluoruro similares a las producidas en la península (todas en un rango de 0,24 a 0,62 mg/L). Los individuos sobre los que recaen las restricciones más amplias de consumo de agua son los menores de un año, pero en cualquier caso, a medida que el individuo crece va aumentando la permisibilidad del aporte de fluoruros (aumenta hasta los 19 años) y, por tanto, aumenta la variedad de aguas envasadas que se pueden consumir sin superar la IDR. En ciertos lugares de la Comunidad Autónoma Canaria sería recomendable consumir agua envasada respecto al agua de abastecimiento público.

  5. [EFFECTS OF VOLUNTARY INTAKE OF FLUIDS (WATER AND SPORTS DRINK) IN AMATEUR MOUNTAIN RUNNERS].

    PubMed

    Nebot, Vicente; Drehmer, Eraci; Elvira, Laura; Sales, Sonia; Sanchís, Carlos; Esquius, Laura; Pablos, Ana

    2015-11-01

    Introducción: las carreras por montaña de 21 km y 1.000 metros de desnivel pueden suponer un riesgo si no se mantiene una adecuada reposición hídrica. Objetivo: conocer los niveles de deshidratación y evaluar las diferencias entre una carrera con ingesta voluntaria de agua (CcA) y bebida deportiva (CcB). Método: 18 sujetos de 31,9 (±2,8) años y %MG 10,53 (±2,8), completaron una CcA o una CcB. Se evaluó el efecto de CcA y CcB sobre cada variable; Peso (P), Masa Grasa (MG), Glucosa (GL), Lactato (LT), Tensión Arterial Sistólica (TAS) y Diastólica (TAD), Pulsaciones por Minuto (PPM) y Temperatura Timpánica (Tª). Estas fueron tomadas al inicio (T1) y al final (T2) de cada prueba. Los efectos se calcularon con la ANOVA Friedman. Las diferencias en las variables tiempo de carrera (TC), % de pérdida de peso (%PP) y líquido ingerido (LI) se evaluaron con la prueba de Wilcoxon. Todos los cálculos se realizaron con el SPSS versión 20.0 (IBM, Somers, NY, USA). Resultado: el % PP fue de 2,967 (± 0,969) y 2,883 (± 0,730), para CcA y CcB. En TC, %PP y LI no hay diferencias (p > .05) entre carreras. Para CcA en función del tiempo, son significativos (p < .05) los cambios en: P, %MG, GL, L, TAS y PPM. Para CcB en función del tiempo, solo son significativos en P y PPM. Conclusiones: ningún líquido consigue evitar que los deportistas se deshidraten. No obstante, los efectos de la deshidratación son mucho más severos ingiriendo solo agua.

  6. [Food habits and health-related behaviors in a university population].

    PubMed

    Sánchez Socarrás, Violeida; Aguilar Martínez, Alicia

    2014-09-18

    Introducción: La población universitaria se considera un colectivo especialmente vulnerable desde el punto de vista nutricional ya que comienza a responsabilizarse de su alimentación y atraviesa un período crítico en la consolidación de hábitos y conductas alimentarias. Estudios previos ponen en evidencia el alejamiento de patrones alimentarios saludables y la necesidad de desarrollar acciones de educación e intervención nutricional. Objetivos: Analizar hábitos y conductas relacionadas con la alimentación en una población universitaria en Cataluña como punto de partida para desarrollar estrategias efectivas en la promoción de la salud. Metodología: Estudio observacional transversal descriptivo de hábitos alimentarios y conductas relacionadas con la alimentación (consumo de alcohol, tabaco y actividad física) en estudiantes universitarios de Cataluña. Resultados: La comida y la cena en casa resultaron las comidas imprescindibles de los estudiantes encuestados mientras el desayuno y la merienda se omitían aproximadamente en un 20% de los casos. El patrón dietético obtenido se caracterizó por un consumo excesivo de carnes rojas (84%) y un consumo deficiente o muy deficiente de verduras (39,8%), cereales (92,6%) y frutas (73,9%). El consumo de alcohol en general resultó escaso, siendo la cerveza la bebida más consumida y la mayor parte afirmaron también no ser fumadores habituales. Entre los fumadores habituales predominaron las mujeres. Un número considerable de estudiantes acostumbraban a realizar actividad física moderada o intensa tres o más veces a la semana, a pesar de que una proporción similar no suele realizar ningún tipo de actividad física de manera habitual. Discusión y conclusiones: En la población estudiada se detectan conductas alimentarias que se alejan de las recomendaciones de la Dieta Mediterránea: un escaso consumo de frutas y verduras, un aumento en el consumo de productos lácteos y un predominio en el consumo de

  7. Les traumatismes de l’étage antérieur de la base du crane: à propos d'une série de 136 cas

    PubMed Central

    Bouchaouch, Abdelali; Hassani, Fahd Derkaoui; Abboud, Hilal; Mukengeshay, Jeff Ntalaja; El Fatemi, Nizare; Gana, Rachid; El Maaqili, Moulay Rchid; El Abbadi, Najia; Bellakhdar, Fouad

    2015-01-01

    Les traumatismes de l’étage antérieur de la base du crâne représentent 15 à 20% des traumatismes crâniens en général. Ils menacent les structures neuro-encéphaliques sus jacentes et sont très souvent responsables de brèches ostéo-méningées exposant au risque infectieux. Notre travail a concerné 136 dossiers exploitables de traumatisme de l’étage antérieur de la base du crâne colligés sur une période de 10 ans entre janvier 2003 et décembre 2012. Le diagnostic a été suspecté devant les signes cliniques évocateurs (ecchymose péri-orbitaire, rhinorrhée…) et a été confirmé dans la plupart des cas par la TDM. Le traitement idéal est la fermeture chirurgicale de la brèche en association aux moyens médicaux (vaccination, anti-épileptiques, mesures de réanimation…) Le moment idéal de la réparation est au-delà de la 72ème heure après la diminution de l'oedème cérébral en cas d'absence d'une lésion intracrânienne nécessitant une intervention en urgence. Notre équipe ne pratiquant pas la voie endoscopique, l'abord frontal est souvent indiqué. Le pronostic dépend des lésions cérébrales associées et surtout de la présence d'une brèche dont le diagnostic et la réparation doivent être les plus rapides et les plus précis possibles. Ainsi toute rhinorrhée post-traumatique nécessite une exploration systématique, le timing idéal: c'est la disparition de l'oedème cérébral pour faciliter l'exploration, ceci est en général possible à partir de la 72ème heure sauf dans les cas associés à une autre lésion intra crânienne nécessitant une exploration en urgence. PMID:26327992

  8. Planning for the Future of Geo-Cybereducation: Outcomes of the Workshop, Challenges, and Future Directions

    NASA Astrophysics Data System (ADS)

    Ryan, J. G.; Eriksson, S. C.

    2010-12-01

    Inspired by the recommendations of the NSF report “Fostering Learning in the Networked World: The Cyberlearning Opportunity and Challenge” (NSF08204), the NSF National STEM Digital Learning program funded “Planning for the Future of Geocybereducation” Workshop sought to bring together leaders from the geoscience education community, from major geoscience research initiatives, and from the growing public- and private-sector geoscience information community. The objectives of the workshop were to begin conversations aimed at identifying best practices and tools for geoscience cyber-education, in the context of both the changing nature of learners and of rapidly evolving geo-information platforms, and to provide guidance to the NSF as to necessary future directions and needs for funding. 65 participants met and interacted live for the two-day workshop, with ongoing post-meeting virtual interactions via a collaborative workspace (www.geocybered.ning.com). Topics addressed included the rapidly changing character of learners, the growing capabilities of geoscience information systems and their affiliated tools, and effective models for collaboration among educators, researchers and geoinformation specialists. Discussions at the meeting focused on the implications of changing learners on the educational process, the challenges for teachers and administrators in keeping pace, and on the challenges of communication among these divergent professional communities. Ongoing virtual discussions and collaborations have produced a draft workshop document, and the workshop conveners are maintaining the workshop site as a venue for ongoing discussion and interaction. Several key challenges were evident from the workshop discussions and subsequent interactions: a) the development of most of the large geoinformatics and geoscience research efforts were not pursued with education as a significant objective, resulting in limited financial support for such activities after the

  9. Providing the Persistent Data Storage in a Software Engineering Environment Using Java/COBRA and a DBMS

    NASA Technical Reports Server (NTRS)

    Dhaliwal, Swarn S.

    1997-01-01

    object providing the persistent data server is implemented using the Java progranu-ning language. It uses the JRB to store/retrieve data in/from a relational database server. The persistent data management system provides transaction and user management facilities which allow multi-user, distributed access to the stored data in a secure manner.

  10. Assessment of new drugs in a tertiary hospital using a standardized tool.

    PubMed

    González-Bueno, J; Chamorro-de-Vega, E; Alfaro-Lara, E R; Galván-Banqueri, M; Santos-Ramos, B

    2013-01-01

    Objetivo: Describir las características de los nuevos fármacos evaluados por la Comisión de Farmacia y Terapéutica (CFyT) en un hospital terciario mediante el empleo de una herramienta normalizada, la Guía para la valoración de Inclusión de Nuevos Fármacos, como objetivo principal. Material y métodos: Estudio observacional retrospectivo de aquellos fármacos evaluados en el periodo 2008-11. Fueron recogidas variables relativas al fármaco, a la solicitud y al resultado final de la evaluación mediante la información contenida en las guías GINF y en los informes finales de evaluación. Resultados: De los 75 medicamentos evaluados, 63 (84%) fueron incluidos en la Guía Farmacoterapéutica del Hospital. Únicamente 1 (1,3%) lo fue sin ningún tipo de restricción. El resto fueron incluidos como equivalentes terapéuticos (21,3%) o bajo recomendaciones específicas (61,3%). La mitad de los fármacos no incluidos (6) presentaban insuficiente evidencia respecto a su eficacia frente a los tratamientos habituales. Hematología y Oncología Médica se encontraron entre los servicios médicos más activos en la solicitud. Se observó un alto porcentaje de fármacos que disponían de más de un ensayo clínico en fase avanzada (III y/o IV). Por otra parte, el 28% de los fármacos evaluados se relacionaron con un impacto financiero superior 10.000 ??anuales. Las guías GINF proporcionadas por los solicitantes a la CFyT se caracterizaron por la alta calidad de la información contenida en ellas. Sin embargo, la relación entre la información proporcionada a la CFyT y la decisión final de la misma no fue estadísticamente significativa. Conclusiones: Las solicitudes recibidas pertenecieron principalmente a fármacos de administración parenteral, siendo la mayor parte de ellos antineoplásicos. Los servicios médicos más intensamente representados fueron Hematología y Oncología.

  11. A Thermal Evolution Model of the Earth Including the Biosphere, Continental Growth and Mantle Hydration

    NASA Astrophysics Data System (ADS)

    Höning, D.; Spohn, T.

    2014-12-01

    By harvesting solar energy and converting it to chemical energy, photosynthetic life plays an important role in the energy budget of Earth [2]. This leads to alterations of chemical reservoirs eventually affecting the Earth's interior [4]. It further has been speculated [3] that the formation of continents may be a consequence of the evolution life. A steady state model [1] suggests that the Earth without its biosphere would evolve to a steady state with a smaller continent coverage and a dryer mantle than is observed today. We present a model including (i) parameterized thermal evolution, (ii) continental growth and destruction, and (iii) mantle water regassing and outgassing. The biosphere enhances the production rate of sediments which eventually are subducted. These sediments are assumed to (i) carry water to depth bound in stable mineral phases and (ii) have the potential to suppress shallow dewatering of the underlying sediments and crust due to their low permeability. We run a Monte Carlo simulation for various initial conditions and treat all those parameter combinations as success which result in the fraction of continental crust coverage observed for present day Earth. Finally, we simulate the evolution of an abiotic Earth using the same set of parameters but a reduced rate of continental weathering and erosion. Our results suggest that the origin and evolution of life could have stabilized the large continental surface area of the Earth and its wet mantle, leading to the relatively low mantle viscosity we observe at present. Without photosynthetic life on our planet, the Earth would be geodynamical less active due to a dryer mantle, and would have a smaller fraction of continental coverage than observed today. References[1] Höning, D., Hansen-Goos, H., Airo, A., Spohn, T., 2014. Biotic vs. abiotic Earth: A model for mantle hydration and continental coverage. Planetary and Space Science 98, 5-13. [2] Kleidon, A., 2010. Life, hierarchy, and the

  12. [Not Available].

    PubMed

    Viñuela García, Manuel; Vera Ibáñez, Antonio; Colomer Poveda, David; Márquez Sánchez, Gonzalo; Romero Arenas, Salvador

    2016-06-30

    Introducción: actualmente los programas de entrenamiento interválicos de alta intensidad parecen ser una forma de optimizar el tiempo, provocando cambios en la composición corporal debido a la activación de diferentes mecanismos hormonales y metabólicos.Objetivo: observar el efecto de cuatro semanas de entrenamiento de esprints repetidos basados en la prueba de Wingate sobre la potencia y la composición corporal en adultos jóvenes.Métodos: los participantes (22,4 ± 1,8 años) fueron asignados aleatoriamente a un grupo experimental o a un grupo control. Antes de comenzar y al acabar el periodo experimental, a los sujetos se les realizó una densitometría de cuerpo completo y una prueba de Wingate. El grupo experimental realizó 12 sesiones de esprints repetidos, realizando de 3 a 6 esprints de 30 segundos con un tiempo de recuperación de 4 minutos. El grupo control continuó con su rutina diaria y no se le aplicó ningún tipo de intervención.Resultados: en el grupo experimental, la potencia media y máxima incrementó un 9,4-16,5% (p < 0,001). Además, disminuyó la masa grasa total un 8,1% (p < 0,028) y la grasa abdominal un 10,0% (p < 0,038). El grupo control no sufrió cambios en ninguna de las variables estudiadas.Conclusiones: cuatro semanas de entrenamiento de esprints repetidos basados en la prueba de Wingate con un volumen específico de ~3 minutos por sesión y una frecuencia de 3 sesiones por semana, muestra mejoras estadísticamente significativas en la potencia máxima y media. Además, provoca cambios en la composición corporal, principalmente en la masa grasa total y de la zona abdominal.

  13. Intuitive eating: an emerging approach to eating behavior.

    PubMed

    Cadena-Schlam, Leslie; López-Guimerà, Gemma

    2014-10-03

    Introducción: Con la finalidad de tratar la obesidad, los profesionales en salud buscan, por medio de intervenciones dietéticas restrictivas y ejercicio, la pérdida de peso como objetivo principal del tratamiento. Aunque en algunos casos estas intervenciones inducen pérdida de peso a corto plazo, en el largo plazo la eficacia de estos tratamientos es, al menos, cuestionable. Investigaciones recientes han sugerido que los tratamientos dirigidos a la pérdida de peso basados en dietas restrictivas no resultan eficaces a largo plazo e incluso pueden comprometer la salud y el bienestar del paciente. En este sentido, algunos investigadores han considerado cambiar el enfoque del tratamiento de la obesidad a un paradigma centrado en la salud y no en la pérdida de peso. Entre los modelos derivados de este nuevo paradigma, Salud a Cualquier Talla (HAES, por sus siglas en inglés) es uno de los más referenciados. Como componente central de este paradigma se sitúa la ingesta intuitiva, la cual se refiere a la confianza en los mecanismos biológicos para regular la ingesta de alimentos (i.e., las señales internas de hambre y saciedad). Recientemente, la ingesta intuitiva ha ganado reconocimiento, pues se ha asociado a diversos parámetros de bienestar físico y psicológico, además, no se ha observado ningún efecto adverso en pacientes que la practican. Objetivo: El presente artículo revisa el concepto de la ingesta intuitiva, así como la evidencia que sustenta este nuevo enfoque. Además, se discute la implicación de cambiar el enfoque convencional de los tratamientos dietéticos a un paradigma centrado en la salud. Diseño: Revisión Narrativa Conclusiones: A pesar de la necesidad de ampliar la investigación de las intervenciones centradas en la salud, este enfoque podría ser una alternativa más prometedora y realista para el abordaje del sobrepeso y la obesidad que los tratamientos de pérdida de peso convencionales.

  14. The significance of meristic variation in Benthosema glaciale (Pisces, Myctophoidei) and of the species distribution off northwest Africa

    NASA Astrophysics Data System (ADS)

    Badcock, Julian

    1981-12-01

    A comparison of meristics (vertebrae, AO photophores, and gill rakers) between populations of the lanternfish Benthosema glaciale from the eastern North Atlantic north of the Gulf of Cadiz, the Canary Current Upwelling Region, and the Mediterranean reaffirms the distinctions made by TåNING (1918, Report on the Danish Oceanographical Expeditions 1908-1910 to the Mediterranean and adjacent seas, 2, 1-154) between Northern Atlantic and Mediterranean forms and furthermore shows that the Upwelling and Mediterranean populations are indistinguishable on the basis of these characters. Although the current systems through the Straits of Gibraltar are such that the potential for contact between the Northern Atlantic and Mediterranean populations exists, no clinal relationship of meristics between them was found in the area of Mediterranean Outflow. This, and observed changes in interspecific relationships held by the Northern population and also the different relationships held by the Northern and Mediterranean populations point strongly to their genetic separation. Consideration of other species showing distribution patterns analagous to those of B. glaciale populations suggests that whilst gene flow between the Mediterranean and Canary Current Upwelling regions must be strongly maintained, that between the Mediterranean and Northern Atlantic is much weaker. Moreover, the evidence suggests that a subpolar-temperate and temperate mesopelagic fish fauna may exist in a pseudoceanic capacity, extending southwards of the Gulf of Cadiz along the northwest African slpe area in the "Mauritanean Upwelling Region". Within the northern sector of this region these species have their centres of abundance over the slope rather than off it, whereas species of other basic distribution patterns (northern and tropical) have their centres further offshore, at least in late winter and early spring. The onslope fauna breeds and thrives around upwelling conditions, whereas the situation

  15. [Do our elderly have an adequate nutritional status?].

    PubMed

    Méndez Estévez, Eugenia; Romero Pita, Juana; Fernández Domínguez, Ma José; Troitiño Álvarez, Patricia; García Dopazo, Silvia; Jardón Blanco, Milagros; Rey Charlo, Manuela; Rivero Cotilla, María Isabel; Rodríguez Fernández, Cristina; Menéndez Rodríguez, Martín

    2013-01-01

    Determinar el estado nutricional de los ancianos de un área de salud rural y ver si la institucionalización es un factor de riesgo. Diseño del estudio: Estudio observacional descriptivo en SAP de Xinzo de Limia 3. Sujetos: El tamaño muestral fue de 311 pacientes mayores de 75 años, seleccionados por muestreo aleatorio simple. Mediciones: Edad, sexo, estado civil, nivel de estudios, institucionalización o no, estado nutricional: valorado mediante el cuestionario MNA y parámetros antropométricos; apoyo social: medido mediante la escala de Duke- Unc; Calidad de vida: con la escala Euro-Quol; patologías asociadas; trastornos de la deglución; tratamiento habitual: tipo de dieta, fármacos. Resultados principales: La mediana de edad era de 82,55 años (DT 4,83 años) y el 51,8% eran mujeres, el 52,7% estaba casado y el 76,8% referían estudios primarios. La mediana de patologías por individuo era del 3 (DT: 1,42) y del número de fármacos usados era de 4 (DT 2,44). El 54,70% vivía acompañado por su pareja u otro familiar. Estaban institucionalizados el 17,4%. La mediana de calidad de vida era de 6,84. Según los resultados del MNA no encontramos ningún caso de desnutrición, pero un 20.3% de los pacientes presentan valores de riesgo. En el análisis multivariante encontramos relación entre la presencia o no de desnutrición y la institucionalización OR = 0,40 (IC 95%, 0,18- 0,87), con el nº de patologías OR = 1,30 (IC 95%, 1,03-1,64), calidad de vida OR = 1,40 (IC 95%, 1,14-1,71). Conclusiones: Los pacientes ancianos validos estudiados presentan un buen estado nutricional. Los pacientes con riesgo de presentar desnutrición son un 20,3%, siendo la institucionalización, los mayores de 85 años con mayor número de patologías los que presentan mayor riesgo de desnutrición. La peor calidad de vida y el menor apoyo social influyen negativamente.

  16. The European Water Framework Directive: Challenges For A New Type of Social and Policy Analysis

    NASA Astrophysics Data System (ADS)

    Pahl-Wostl, C.

    Water resources managment is facing increasing uncertainties in all areas. Socio- economic boundary conditions change quickly and require more flexible management strategies. Climate change, for example results in an increase in uncertainties, in par- ticular extreme events. Given the fact that current management practices deal with extreme events by designing the technical systems to manage the most extreme of all cases (e.g. higher dams for the protection against extreme floods, larger water reser- voirs for droughts and to meet daily peak demand) a serious problem is posed for long-term planning and risk management. Engineering planning has perceived the hu- man dimension as exogenous boundary conditions. Legislation focused largely on the environmental and technological dimensions that set limits and prescribe new tech- nologies without taking the importance of institutional change into account. However, technology is only the "hardware" and it is becoming increasingly obvious that the "software", the social dimension, has to become part of planning and management processes. Hence, the inclusion of the human dimension into integrated models and processes will be valuable in supporting the introduction of new elements into plan- ning processes in water resources management. With the European Water Framework Directive environmental policy enters a new era. The traditional approach to solving isolated environmental problems with technological fixes and end-of-pipe solutions has started to shift towards a more thoughtful attitude which involves the development of integrated approaches to problem solving. The WFD introduces the river basin as the management unit, thus following the experience of some European countries (e.g. France) and the example of the management of some international rivers (e.g. the Rhine). Overall the WFD represents a general shift towards a polycentric understand- ing of policy making that requires the involvement of stakeholders as active

  17. Arthrite à pneumocoque chez un adulte immunocompétent

    PubMed Central

    Chemsi, Hicham; Chadli, Maryama; Sekhsokh, Yassine

    2015-01-01

    Les infections à pneumocoques sont avant tout respiratoires, ORL et méningées. Les infections ostéoarticulaires à pneumocoque ont la particularité de survenir dans moins de 20% des cas chez l'adulte sain. Habituellement, un ou plusieurs facteurs favorisants sont retrouvés. Toutefois, nous rapportons lors de cette observation le cas d'une arthrite à Streptococcus pneumoniae chez un adulte immunocompétent sans facteurs prédisposant. Patient âgé de 66 ans, diabétique de type II, a été hospitalisé pour une décompensation acido-cétosique et une monoarthrite du genou droit. Ce patient était fébrile (39°C) et présentait un genou droit inflammatoire en flexion avec rougeur et chaleur locale et un choc rotulien. Une ponction articulaire avec d'autres examens ont été réalisés pour confirmation d'une arthrite septique à pneumocoque. Le résultat de la ponction articulaire réalisée a montré un liquide jaune citron trouble avec 480 000 leucocytes/mm3 à prédominance polynucléaires neutrophiles. L'examen direct a montré des coccis à Gram positif en diplocoque, la culture a permis d'isoler un Streptococcus pneumoniae sensible à la pénicilline G. L’évolution clinique et biologique de l'arthrite du genou était favorable. Un déficit immunitaire, un asplénisme anatomique ou fonctionnel peuvent être en cause. L'alcoolisme est un facteur favorisant mais le mécanisme n'est pas clairement élucidé. La présence de matériel prothétique, peut favoriser une localisation septique. Ces facteurs de risque doivent être systématiquement recherchés, notamment en cas d'infection grave ou récidivante, une antibioprophylaxie ou une vaccination pouvant être proposées chez les sujets à haut risque. PMID:26327976

  18. Voting Systems for Environmental Decisions

    PubMed Central

    BURGMAN, MARK A; REGAN, HELEN M; MAGUIRE, LYNN A; COLYVAN, MARK; JUSTUS, JAMES; MARTIN, TARA G; ROTHLEY, KRIS

    2014-01-01

    Voting systems aggregate preferences efficiently and are often used for deciding conservation priorities. Desirable characteristics of voting systems include transitivity, completeness, and Pareto optimality, among others. Voting systems that are common and potentially useful for environmental decision making include simple majority, approval, and preferential voting. Unfortunately, no voting system can guarantee an outcome, while also satisfying a range of very reasonable performance criteria. Furthermore, voting methods may be manipulated by decision makers and strategic voters if they have knowledge of the voting patterns and alliances of others in the voting populations. The difficult properties of voting systems arise in routine decision making when there are multiple criteria and management alternatives. Because each method has flaws, we do not endorse one method. Instead, we urge organizers to be transparent about the properties of proposed voting systems and to offer participants the opportunity to approve the voting system as part of the ground rules for operation of a group. Sistemas de Votación para Decisiones Ambientales Resumen Los sistemas de votación agregan preferencias eficientemente y muy seguido se usan para decidir prioridades de conservación. Las características deseables de un sistema de votación incluyen la transitividad, lo completo que sean y la optimalidad de Pareto, entre otras. Los sistemas de votación que son comunes y potencialmente útiles para la toma de decisiones ambientales incluyen simple mayoría, aprobación y votación preferencial. Desafortunadamente, ningún sistema de votación puede garantizar un resultado y a la vez satisfacer un rango de criterios de desempeño muy razonable. Además, los métodos de votación pueden manipularse por los que toman las decisiones y votantes estratégicos si tienen el conocimiento de los patrones de votación y de las alianzas entre miembros dentro de las poblaciones votantes. Las

  19. Facteurs associés à la tuberculose chez l'enfant au Centre Hospitalier Universitaire Mère-Enfant de Tsaralalàna, Antananarivo: une étude cas-témoins

    PubMed Central

    Randriatsarafara, Fidiniaina Mamy; Vololonarivelo, Barbara Elyan Edwige; Rabemananjara, Nambinina Nirina Gaby; Randrianasolo, Jean Baptiste Olivier; Rakotomanga, Jean de Dieu Marie; Randrianarimanana, Vahiniarison Dieudonné

    2014-01-01

    Introduction A Madagascar, la tuberculose reste un problème de santé publique majeur, l'incidence s’élevant à 16% depuis 2009. Le présent travail a pour objet d'identifier les facteurs de risque de tuberculose chez l'enfant. Méthodes Nous avons mené une étude rétrospective de type cas-témoins sur les facteurs de risque de la tuberculose chez les enfants de 0 à 15 ans au Centre Hospitalier Universitaire Mère-Enfant de Tsaralalàna, de Janvier 2009 à Décembre 2011. Les enfants diagnostiqués de tuberculose dont le diagnostic a été retenu par des éléments de certitude ou par le score pédiatrique de la tuberculose représentent les cas. Les enfants hospitalisés durant la même période, non tuberculeux et de même âge, sont classés témoins. L'Odds Ratio quantifie les associations. Résultats Au total, 91 cas et 173 témoins ont été inclus. Parmi les cas, 73,62% présentent une malnutrition. De fortes associations sont démontrées avec: la malnutrition sévère (OR=6 (IC95% 2,43-15,61 (p<10-5))); le contage tuberculeux (OR=4,71 (IC95% 1,76-12,7 (p=0,003))); la non vaccination par le BCG (OR=4,21 (IC95% 1,99-8,99 (p < 2.10-5))); le niveau intellectuel maternel bas (OR=4,17 (IC95% 0,67-28,14 (p=0,06))); la taille de la fratrie à partir de 5 (OR=4,5). Des associations faibles sont retrouvées pour les autres facteurs étudiés. Les cas présentent une létalité de 18,7% contre 6,3% chez les témoins (p<10-5); 64,7 % des décès sont dus aux formes méningées. Conclusion La tuberculose reste un fléau chez les enfants, avec une lourde responsabilité de la pauvreté rassemblant presque tous les facteurs sus-cités. PMID:25838852

  20. Effect of Weikangning on gastric cancer cell growth and expression of vascular endothelial growth factor and its receptors KDR and Flt-1

    PubMed Central

    Li, Qing-Ming; Kan, Fang-Ju; Min, Cun-Yun

    2005-01-01

    AIM: To observe the effect of Chinese traditional herbal decoction Weikang-ning (WKN) on cell growth and expression of VEGF and its receptors KDR and Flt-1 in gastric cancer cell line MGC-803. METHODS: A total of 120 male Wistar rats were divided into control group, high dose, medium dose and low dose groups fed with natural saline, 20, 10, and 5 g/kg of WKN, respectively. The experimental animals were finally killed for the preparation of drug-containing serum. The gastric cancer cell MGC-803 was cultured with the drug-containing serum drawn from the rats in different groups. We observed the growth condition of the cancer cells with light microscope and flow cytometer. The expression of mRNA of VEGF and its receptors KDR and Flt-1 was detected with RT-PCR. RESULTS: The proportion of cells in G0-G1 phase was (65.40±0.41)%, (56.92±0.62)%, (55.89±0.69)% in high, medium and low dose groups respectively vs (41.35±0.55)% in control group (P<0.01), while the cells in G2-S and S phases were (11.62±0.62)% and (22.99±0.69)%, (17.08±0.80)% and (26.00±0.71)%, (19.37±0.57)% and (24.74±0.64)% in high, medium and low dose groups, respectively, vs (23.65±0.56)% and (35.00±0.60)% in control group (P<0.01). The expression of mRNA of VEGF and its receptors was significantly decreased, the area of electrophoresis bands (AREA), the absorptivity of mean optical density (A) and the product of AREA and A were significantly lower in WKN-administered groups than that in control group (P<0.01). CONCLUSION: The decoction of WKN suppresses the growth of gastric cancer cell MGC-803 and decreases the expression of mRNA of both VEGF and its receptors KDR and Flt-1. PMID:15742392

  1. Nontargeted diagnostic ion network analysis (NINA): A software to streamline the analytical workflow for untargeted characterization of natural medicines.

    PubMed

    Ye, Hui; Zhu, Lin; Sun, Di; Luo, Xiaozhuo; Lu, Gaoyuan; Wang, Hong; Wang, Jing; Cao, Guoxiu; Xiao, Wei; Wang, Zhenzhong; Wang, Guangji; Hao, Haiping

    2016-11-30

    The characterization of herbal prescriptions serves as a foundation for quality control and regulation of herbal medicines. Previously, the characterization of herbal chemicals from natural medicines often relied on the analysis of signature fragment ions from the acquired tandem mass spectrometry (MS/MS) spectra with prior knowledge of the herbal species present in the herbal prescriptions of interest. Nevertheless, such an approach is often limited to target components, and it risks missing the critical components that we have no prior knowledge of. We previously reported a "diagnostic ion-guided network bridging" strategy. It is a generally applicable and robust approach to analyze unknown substances from complex mixtures in an untargeted manner. In this study, we have developed a standalone software named "Nontargeted Diagnostic Ion Network Analysis (NINA)" with a graphical user interface based on a strategy for post-acquisition data analysis. NINA allows one to rapidly determine the nontargeted diagnostic ions (NIs) by summarizing all of the fragment ions shared by the precursors from the acquired MS/MS spectra. A NI-guided network using bridging components that possess two or more NIs can then be established via NINA. With such a network, we could sequentially identify the structures of all the NIs once a single compound has been identified de novo. The structures of NIs can then be used as "priori" knowledge to narrow the candidates containing the sub-structure of the corresponding NI from the database hits. Subsequently, we applied the NINA software to the characterization of a model herbal prescription, Re-Du-Ning injection, and rapidly identified 56 herbal chemicals from the prescription using an ultra-performance liquid chromatography quadrupole time-of-flight system in the negative mode with no knowledge of the herbal species or herbal chemicals in the mixture. Therefore, we believe the applications of NINA will greatly facilitate the characterization

  2. Foraminotomia cervical posterior en el tratamiento de conflictos foraminales

    PubMed Central

    Campero, Álvaro; Barrera, Ramiro; Ajler, Pablo

    2012-01-01

    Introducción: La foraminomotima cervical posterior es un procedimiento utilizado para la descompresion radicular por via posterior y constituye una alternativa a la via clásica anterior. En este trabajo evaluamos nuestra serie de pacientes tratados por esta via. Método: Desde enero de 2008 a diciembre de 2011, 17 pacientes (18 foraminotomías) fueron operados por presentar cervicobraquialgia a causa de un conflicto foraminal, realizando un foraminotomía cervical posterior. Los pacientes fueron evaluados en el postoperatorio inmediato, al mes y a los 3 meses de la cirugía. Los parámetros para valorar los resultados fueron la Escala Análoga del Dolor (VAS), la Neck Disability Index y los criterios de Odom. Resultados: El dolor radicular por conflicto foraminal secundario a hernia de disco cervical fue el síntoma y la patología predominante. El nivel más afectado fue C5-C6. La resolución completa del dolor radicular se observó en casi todos los pacientes. La VAS preoperatoria en promedio fue de 8.8 (mínimo 8 – máximo 10), con una franca mejoría en todos los casos (0.4 en el último control). La media en la Neck Disability Index al inicio fue de 35.3 (mínimo 32 – máximo 45), con una evolución favorable en la evaluación final (0.6). Los Criterios de Odom para la evaluación de pacientes operados de columna cervical fueron satisfactorios con un promedio de 1.17. Se observaron complicaciones en 4 pacientes (23%), todas tuvieron una evolución favorable. No hubo infecciones, discitis ni empeoramiento de los síntomas preexistentes en ningún paciente. Conclusión: La foraminotomía cervical posterior es un procedimiento efectivo para el tratamiento del dolor radicular en los conflictos foraminales PMID:23596556

  3. THE EFFECT OF DIETARY WHEAT BRAN ON SUCROSE-INDUCED CHANGES OF SERUM GLUCOSE AND LIPIDS IN RATS.

    PubMed

    Numan Ahmad, Mousa; Rabah Takruri, Hamid

    2015-10-01

    Introducción: son conocidos los muchos beneficios del salvado de trigo para la salud, pero su glucosa y la actividad hipolipemiante aún sigue sin resolverse. Objetivos: investigar los efectos de cantidades variables de salvado de trigo en la alimentación sobre la glucosa en suero y los lípidos en ratas alimentadas con sacarosa. Métodos: se asignaron a ochenta ratas Sprague-Dawley macho cuatro dietas a base de sacarosa que contenían 0, 5, 10 o 20% de salvado de trigo (WB) dadas ad libitum a las ratas durante 4, 8, 12 o 16 semanas. Glucosa sérica, colesterol total (CT), colesterol de baja y alta densidad de lipoproteínas (LDL -C y HDL -C), los triglicéridos (TG), fosfolípidos (PL) y lípidos totales (TL) se cuantificaron al final de cada período de alimentación y otros parámetros biológicos se evaluaron. Resultados: en todos los períodos de alimentación, la ingesta de alimentos mostró una tendencia lineal ascendente (p < 0,05), mientras que el peso corporal no respondió a WB. En comparación con 0%, 10% o 20 inducida WB disminución (p < 0.05) en TC (16 semanas) y HDL-C (12 o 16 semanas), mientras que 5, 10 o 20% WB inducida disminución similar en PL (4 o 12 semanas), TL (todos los períodos) y glucosa (4 u 8 semanas). Este efecto de glucosa y lípidos bajar se justificó descendiendo respuestas lineales (p < 0.05) a WB. PL y TL descendente respuestas a WB se observaron en todos los períodos de alimentación. TG exhibió ningún cambio con WB, pero respondió linealmente (4 u 8 semanas). Las diferencias en la glucosa o lípidos variables de ratas alimentadas con dietas WB para todos los períodos de alimentación fueron menos evidentes. Conclusiones: los resultados sugieren que el salvado de trigo reduce la glucosa y los lípidos en suero, principalmente fosfolípidos, en ratas alimentadas con sacarosa en una interacción que puede tener implicaciones clínicas en condiciones cardiometabólicas.

  4. EFFECT OF CHIA SEED (SALVIA HISPANICA L.) CONSUMPTION ON CARDIOVASCULAR RISK FACTORS IN HUMANS: A SYSTEMATIC REVIEW.

    PubMed

    de Souza Ferreira, Cynthia; dd Sousa Fomes, Lucilia de Fátima; da Silva, Gilze Espirito Santo; Rosa, Glorimar

    2015-11-01

    ólica (PAS) y los marcadores de inflamación; sin embargo, no hubo cambios en la masa corporal, el perfil de lípidos o el azúcar en sangre. En cuatro de los estudios revisados no había un pico significativo en ALA y ácido eicosapentaenoico (EPA), ni ningún cambio significativo en otros parámetros. En los ensayos agudos, el nivel postprandial de azúcar en sangre fue significativamente menor. Solo un estudio mostró un descenso significativo de los triglicéridos (TG), la masa corporal y los marcadores inflamatorios; sin embargo, la semilla de chía en ese caso se mezcló con otros alimentos. La mayoría de los estudios mostraron riesgos claros o bajo sesgo. Dos estudios mostraron un alto riesgo de sesgo, porque no todos los resultados primarios preespecificados fueron reportados en los hallazgos. Conclusión: la mayoría de los estudios no demostraron resultados estadísticamente significativos en relación con los factores de riesgo cardiovascular (ECV). La evidencia sobre la relación entre el consumo de semillas de chía y los factores de riesgo cardiovascular son insuficientes, y los estudios incluidos en esta revisión presentan numerosas limitaciones. Por lo tanto, se necesita más investigación.

  5. THE EFFECT OF GARCINIA CAMBOGIA AS COADJUVANT IN THE WEIGHT LOSS PROCESS.

    PubMed

    Fassina, Patricia; Scherer Adami, Fernanda; Terezinha Zani, Valdeni; Kasper Machado, Isabel Cristina; Garavaglia, Juliano; Quevedo Grave, Magali Terezinha; Ramos, Renata; Morelo Dal Bosco, Simone

    2015-12-01

    grasa corporal, triglicéridos, niveles de colesterol y glucosa y proceso de lipogénesis; mientras que en otros no produjo ningún efecto. Conclusión: los estudios sugieren resultados positivos con respecto a la eficacia de la GC en el proceso de pérdida de peso. Sin embargo, la dosis ideal no ha sido aún bien establecido. Hay poca evidencia de efectos adversos y signos de efecto protector contra la hepatotoxicidad inducida por el etanol. Por lo tanto, se hace necesario llevar a cabo más estudios para confirmar la eficacia de esta fitoterapia en el proceso de pérdida de peso.

  6. Causes de décès des patients infectés par le VIH dans le Centre tunisien

    PubMed Central

    Chelli, Jihène; Bellazreg, Foued; Aouem, Abir; Hattab, Zouhour; Mesmia, Hèla; Lasfar, Nadia Ben; Hachfi, Wissem; Masmoudi, Tasnim; Chakroun, Mohamed; Letaief, Amel

    2016-01-01

    La trithérapie antirétrovirale a contribué à une baisse considérable de la mortalité liée au VIH. Les causes de décès sont dominées par les infections opportunistes dans les pays en voie de développement et par les maladies cardiovasculaires et les cancers dans les pays développés. L’objectif était de déterminer les causes et les facteurs de risque de décès des patients infectés par le VIH dans le Centre Tunisien. Une étude transversale auprès des patients infectés par le VIH âgés de plus de 15 ans suivis à Sousse et à Monastir entre 2000 et 2014. Le décès était considéré lié au VIH si la cause était un évènement classant SIDA ou s’il était la conséquence d’une infection opportuniste d’étiologie indéterminée avec des CD4 < 50/mm3, non lié au VIH si la cause n’était pas un évènement classant SIDA, et de cause inconnue si aucune information n’était disponible. Deux cents treize patients, 130 hommes (61%) et 83 femmes (39%), d’âge moyen 40±11 ans ont été inclus. Cinquante quatre patients sont décédés, avec une mortalité de 5,4/100 patients-années. La mortalité annuelle a baissé de 5,8% en 2000-2003 à 2,3% en 2012-2014. La survie était de 72% à 5 ans et de 67% à 10 ans. Les décès étaient liés au VIH dans 70,4% des cas. Les causes de décès les plus fréquentes étaient la pneumocystose pulmonaire et la cryptococcose neuroméningée dans 6 cas (11%) chacune. Les facteurs de risque de décès étaient les antécédents d’infections opportunistes, la durée de la trithérapie antirétrovirale < 12 mois et le tabagisme. Le renforcement du dépistage, l’initiation précoce de la trithérapie antirétrovirale, et la lutte contre le tabagisme sont nécessaires afin de réduire la mortalité chez les patients infectés par le VIH en Tunisie. PMID:28292068

  7. Use of the SAR (Synthetic Aperture Radar) P band for detection of the Moche and Lambayeque canal networks in the Apurlec region, Perù

    NASA Astrophysics Data System (ADS)

    Ilaria Pannaccione Apa, Maria; Santovito, Maria Rosaria; Pica, Giulia; Catapano, Ilaria; Fornaro, Gianfranco; Lanari, Riccardo; Soldovieri, Francesco; Wester La Torre, Carlos; Fernandez Manayalle, Marco Antonio; Longo, Francesco; Facchinetti, Claudia; Formaro, Roberto

    2016-04-01

    , glaciers investigation, biomass monitoring, detection of buried targets. Its extension to non-civil application concerns sub-surface target detection and foliage penetration (FOPEN). In order to achieve the flexibility to face all the above mentioned fields of application, the CORISTA system has been designed as a multi-mode and multi-frequency radar. Multimode stands for the functionality of the system both as Sounder and Imager. In addition, P-band radar is a multi-frequency instrument, since it is designed to work in three different frequency bands, as mentioned above: lower frequency band is used in sounder operative mode, higher frequency in imager operative mode. In the Imager operative mode, low resolution and high resolution capabilities are implemented. The data collected by the radar system have been processed using a model-based microwave tomographic approach, recently developed by IREA-CNR, with the aim to enhance the interpretability of the raw-data radar images. Currently, the non-invasive SAR P band application is under evaluation for testing in the Northern Coast of Perù, in collaboration with the Museo Arqueológico Nacional Brüning. The project will aim to recognize the subsurface ancient Moche (100-700 d.C.) and Lambayeque (700-1375 d.C.) canal networks, whose water supply comes from the Canal Taymi, started to be dug by the Mochicas, still in use by local communities.

  8. Science for avian conservation: priorities for the new millennium

    USGS Publications Warehouse

    Ruth, J.M.; Petit, D.R.; Sauer, J.R.; Samuel, M.D.; Johnson, F.A.; Fornwall, M.D.; Korschgen, C.E.; Bennett, J.P.

    2003-01-01

    Over the past decade, bird conservation activities have become the preeminent natural resource conservation effort in North America. Maturation of the North American Waterfowl Management Plan (NAWMP), establishment of Partners in Flight (PIF), and creation of comprehensive colonial waterbird and shorebird conservation plans have stimulated unprecedented interest in, and funding for, bird conservation in the United States, Canada, Mexico, and other countries in the western hemisphere. Key to that success in the United States has been active collaboration among federal, state and local governments, conservation organizations, academia, and industry. The U.S. Department of the Interior (DOI), which has primary statutory responsibility for migratory bird conservation and management, has been a key partner. Despite the great strides that have been made in bird conservation science, historical approaches to research and monitoring have often failed to provide sufficient information and understanding to effectively manage bird populations at large spatial scales. That shortcoming, and the lack of an integrated strategy and comprehensive set of research priorities, is more evident in light of the goals established by the North American Bird Conservation Initiative (NABCI). The NABCI is a trinational, coalition-driven effort to provide an organizational umbrella for existing conservation initiatives. The expanded focus of NABCI and individual bird conservation initiatives is to work together in an integrated, holistic fashion to keep common birds common and to increase populations of declining, threatened, and endangered species. To assist bird conservation initiatives in defi ning goals and developing new approaches to effective research, the U.S. Geological Survey (USGS), the research agency of DOI, convened a workshop, a??Science for Avian Conservation: Understanding, Modeling, and Applying Ecological Relationships,a?? on 31 Octobera??2 November 2000, which brought

  9. [INFLUENCE OF THE NUTRITIONAL COMPOSITION OF DIFFERENT FIBER-ENRICHED ENTERAL NUTRITION FORMULAS ON THE ADMINISTRATION TIME BY GRAVITY AND THE RISK OF TUBE FEEDING OBSTRUCTION].

    PubMed

    Bonada Sanjaume, Anna; Gils Contreras, Anna; Salas-Salvadó, Jordi

    2015-08-01

    Introducción: la administración de nutrición enteral por gravedad es un método de administración muy útil en la práctica clínica, pero a la vez muy poco preciso y que presenta unas limitaciones importantes, como la dificultad a la hora de establecer una velocidad de goteo precisa y la probabilidad de enlentecimiento del goteo según la fórmula administrada. Objetivos: evaluar el tiempo de paso de caída libre y el riesgo de obturación de cinco fórmulas de nutrición enteral ricas en fibra con diferente concentración proteica y densidad calórica, administradas por gravedad a través de sondas nasogástricas (SNG) de diferentes calibres. Valorar la influencia de la composición en la velocidad de paso por gravedad de las fórmulas estudiadas. Métodos: se compararon cinco fórmulas de NE ricas en fibra de distintos tipos y se utilizaron SNG con un calibre de 8, 10 y 12 Fr. La fluidez de las fórmulas de NE por gravedad se estimó cronometrando el tiempo de paso de cada fórmula a máxima velocidad y se calculó el tiempo medio de caída libre (TMCL), registrándose las posibles obturaciones. Posteriormente se realizó una simulación in vitro de la administración de 1.500 ml de cada una de las fórmulas a una velocidad determinada para que el producto pasara en cinco horas. Se registró el enlentecimiento y la detención del paso como indicadores de riesgo de obturación. Resultados: los dos productos que con diferencia presentaron un mayor TMCL fueron los productos de mayor concentración energética. El tiempo de paso en caída libre de estos dos productos a través de la sonda de 8 Fr superó las cuatro horas. Para el resto de los productos y SNG utilizadas el tiempo fue inferior a dos horas y cinco minutos. No se detectó enlentecimiento del paso ni obturación de la sonda en ningún caso cuando se determinó el tiempo de caída libre a máxima velocidad. Cuando se ajustó la velocidad para que el producto pasara en cinco horas, en tres de los

  10. Habitability constraints on water-rich exoplanets

    NASA Astrophysics Data System (ADS)

    Noack, Lena; Höning, Dennis; Rivoldini, Attilio; Heistracher, Clemens; Zimov, Nastasia; Journaux, Baptiste; Lammer, Helmut; Van Hoolst, Tim; Hendrik Bredehöft, Jan

    2016-04-01

    appear episodically at the water-mantle boundary (WMB). We also investigated the main paramters influencing the existence of volcanic activity and silicate crust formation. Under deep water layers, the high pressure from the overlying water layer can inhibit melting in the mantle. The main parameters influencing the maximal water layer depth, for which melting is still possible, are indeed the parameters influencing the mantle energy budget, which are the amount of radioactive heat sources and the initial upper mantle temperature. Plate tectonics also has a strong influence on the existence of volcanism. Crustal parameters (initial thickness or heat sources enrichment factor) as well as the ice rheology (i.e. the isolating effect of the ice shell on the mantle) have only a small influence on melting processes in the interior and the formation of crust. [1] L. Noack, A. Rivoldini and T. Van Hoolst 2015: CHIC - Coupling Habitability, Interior and Crust: A new Code for Modeling the Thermal Evolution of Planets and Moons. INFOCOMP 2015, ISSN 2308-3484, ISBN 978-1-61208-416-9, pp. 84-90, IARIA, 2015. [2] L. Noack, D. Höning, A. Rivoldini, C. Heistracher, N. Zimov, B. Journaux, H. Lammer, T. Van Hoolst and J.H. Bredehöft: Water-rich planets: how habitable is a water layer deeper than on Earth? Submitted to Icarus.

  11. Betaine: a potential agent for the treatment of hepatopathy associated with short bowel syndrome.

    PubMed

    Teixeira Araújo, Guilherme; Domenici, Fernanda; Elias, Jorge; Vannucchi, Hélio

    2014-06-01

    Introducción: La hepatopatía asociada con el síndrome del intestino corto (SIC) es una enfermedad multifactorial asociada con un mal pronóstico. Además de trasplante intestinal, ningún otro tratamiento ha demostrado ser eficaz. El actual estudio evaluó la eficacia de la betaína para el tratamiento de la hepatopatía asociada a la SIC. Métodos: Fue realizado un estudio prospectivo, unicéntrico, no controlado con placeb. Después de la evaluación inicial, 10 g de betaína anhidra fue administrado a pacientes con SIC en dos dosis divididas durante tres meses. La esteatosis hepática se evaluó a través de resonancia magnética nuclear (RMN), la respuesta inflamatoria por la interleucina-6 (IL-6), factor de necrosis tumoral-(TNF-) y la ferritina, además de la lesión hepática por medio de enzimas hepáticas y de la bilirrubina. Además, el efecto de la betaína sobre la homocisteína fue evaluada así como su seguridad y tolerabilidad en este grupo de pacientes. Resultados: Después de la administración de la betaína por tres meses, los pacientes mostraron disminución de la porcentaje de grasa hepática (p = 0,03) demosntrado por examen de RMN trifásico. No hubo una reducción significativa de los niveles séricos de proteínas inflamatorias y marcadores de lesión hepática. La homocisteína también no presentó disminución significativa. Los efectos secundarios más frecuentes fueron diarrea y náuseas, presentado en 62% de los participantes, sin embargo, estos síntomas fueron transitorios y no lo suficientemente graves como para justificar la interrupción del tratamiento. Pacientes dependientes de nutrición parenteral no presentaron diferentes grados de lesión hepática en comparación con los pacientes que no necesitan el uso prolongado de la misma. Conclusiones: La betaína demostró ser un agente potencial para el tratamiento de la hepatopatía asociada a la SIC, que se evidenció mediante RMN, a pesar de los marcadores de lesi

  12. EFFECTS OF OATS ON LIPID PROFILE, INSULIN RESISTANCE AND WEIGHT LOSS.

    PubMed

    Schuster, Jessica; Benincá, Gabriela; Vitorazzi, Renata; Morelo Dal Bosco, Simone

    2015-11-01

    Introducción: las enfermedades cardiovasculares son la principal causa mundial de morbilidad y mortalidad. Esta prevalencia justifica la importancia de los alimentos funcionales que promueven la salud cardiovascular, como el -glucano, presente en la avena, con potenciales efectos hipocolesterolémicos e hipoglucemiantes. Objetivo: evaluar los efectos de una intervención con la harina de avena en los niveles de glucosa en sangre, el índice HOMA-IR, el perfil de lípidos, el peso y el índice de masa corporal (IMC) de los usuarios adultos de un servicio de salud en Río Grande do Sul, Brasil. Métodos: estudio longitudinal, controlado, realizado con personas de 22-60 años de edad, usuarios de un servicio de salud. Los individuos fueron asignados al grupo control (dieta habitual) o grupo Case (dieta habitual + 40 g de avena/día). Al inicio del estudio y después de ocho semanas de seguimiento se evaluaron el peso y la altura, calculado IMC, la sangre recolectada para la medición de glucemia en ayunas, insulina, triglicéridos, colesterol total y colesterol HDL; y se calculó el colesterol LDL y el índice HOMA-IR. Los datos se expresan como media ± desviación estándar y porcentajes. Se aplicaron el test Kolmogorov-Smirnov, la t de Student, el test Mann-Whitney y las pruebas de Wilcoxon. Se adoptó un nivel de significación del 5% (p < 0,05). Resultados: la muestra estuvo constituida por 82 sujetos, divididos en casos (n = 38) y controles (n = 44) con una edad media de 40,07 ± 10,49 años, 58,5% mujeres. Comparando los resultados de todos los parámetros medidos al inicio del estudio y después de ocho semanas de seguimiento, el grupo de control no obtuvo una reducción significativa en ningún parámetro, mostrando un aumento significativo de la glucosa en sangre y HOMA-IR (p < 0,05). El grupo de intervención obtuvo una reducción significativa de todos los indicadores antropométricos y bioquímicos analizados (p < 0,001). Conclusión: los resultados

  13. [Effectiveness of plerixafor in patients undergoing mobilization autologous haematopoietic progenitor cell].

    PubMed

    Ruano Camps, R; Ortiz Pareja, M; Vidales Mancha, I; Muñoz Castillo, I M; Heiniger Mazo, A I

    2013-01-01

    Objetivo: Evaluar efectividad del tratamiento con plerixafor en pacientes sometidos a movilización para posterior autotrasplante de progenitores hematopoyéticos en nuestro hospital. Métodos: Estudio retrospectivo de todos los pacientes que hasta septiembre 2012, recibieron plerixafor en su esquema de movilización de progenitores hematopoyéticos a sangre periférica. Se revisaron las historias clínicas y los registros de dispensación de medicamentos de la consulta de pacientes externos. Las variables de efectividad utilizadas fueron: CD34/kg en producto de aféresis obtenidas, dosis y días recibidos de factor estimulante de colonias (G-CSF) y de plerixafor. Para cada paciente se comparó los resultados de efectividad del fármaco con los obtenidos para anteriores esquemas de movilización en los que no se utilizó plerixafor, en caso de tenerlos. Los datos se analizaron mediante IBM spss v19. Resultados: Un total de 24 pacientes recibieron plerixafor en nuestro hospital. Los diagnósticos se distribuyeron: 15 linfoma no Hodgkin , 6 pacientes con mieloma múltiple, 2 enfermedad de Hodgkin, y 1 coriocarcinoma diseminado. Los resultados de efectividad fueron: Movilización sin plerixafor (n = 18): 5 pacientes se movilizaron sólo con G-CSGF, 13 con G-CSF y quimioterapia. La dosis de G-CSF /día fue de 931,1 mcg (± 179,5), durante 9,5 días (± 4,7). El promedio de CD34/kg en producto obtenido fue de 0,2 células (± 0,5). Ningún paciente obtuvo producto suficiente (≥?2 x 106 células/kg) para el posterior autotrasplante. El 100 % de las movilizaciones fracasaron. Movilización con plerixafor (n = 24): 13 pacientes se movilizaron sólo con G-CSGF, 11 con G-CSF y quimioterapia. La dosis de G-CSF /día y de plerixafor promedio fue de 885,1 mcg (± 240,1) y 19,8 (± 4,4), respectivamente, administrados durante 8,9 (± 5,1) y 1,5 (± 0,6) días, respectivamente. El promedio de CD34/kg en producto obtenido fue de 2,3x106 células (±1,7) (p = 0,014, en relaci

  14. TREATMENT OF SUBCLINICAL HYPERTHYROIDISM: EFFECT ON BODY COMPOSITION.

    PubMed

    Boj-Carceller, Diana; Sanz-París, Alejandro; Sánchez-Oriz, Enrique; García-Foncillas López, Rafael; Calmarza-Calmarza, Pilar; Blay-Cortes, Vicente; Abós-Olivares, Ma Dolores

    2015-11-01

    Introducción: el hipertiroidismo subclínico (HS) se asocia a efectos deletéreos sobre el sistema cardiovascular, el metabolismo óseo y puede progresar a hipertiroidismo clínico. La pérdida de peso es habitual en los pacientes con hipertiroidismo clínico y adquiere especial relevancia en los sujetos añosos. Objetivo: evaluar los cambios en la composición corporal después del tratamiento del HS por bocio nodular con radioyodo. Sujetos y métodos: estudio de cohortes prospectivo controlado. A los pacientes con HS persistente debido a bocio nodular tóxico se les ofreció la opción de recibir tratamiento con radioyodo (grupo tratamiento) o retrasar dicho tratamiento hasta que el estudio hubiera acabado (grupo control). Al final, todos los pacientes recibieron 555 MBq de 131I. La composición corporal (masa magra, masa grasa y contenido mineral óseo) se determinó por absorciometría con rayos X de doble energía (DEXA) al inicio y a los 12 meses. Resultados: se estudiaron 29 pacientes (edad 69,5 ± 11,5; 75,9% mujeres; BMI 27,1 ± 5,7 kg/m²; tirotropina sérica (TSH) 0,20 ± 0,21 μUI/mL; tiroxina libre sérica(T4) 1,01 ± 0,19 ng/dL), 17 pertenecientes al grupo tratamiento y 12 al grupo control. Los grupos de estudio fueron comparables, aunque existía una tendencia del grupo tratamiento a presentar más masa grasa. No se detectaron cambios en la composición corporal en ningún grupo, salvo una tendencia general a ganar masa grasa. Sin embargo, cuando se seleccionaron los individuos con edad > 65 años, sólo los pacientes que recibieron tratamiento con radioyodo mostraron un significativo incremento de peso (de 64,1 ± 10,0 a 66,9 ± 9,2 kg), IMC (de 27,3 ± 4,8 a 28,7 ± 4,5 kg/m²), masa grasa (de 26,1 ± 8,5 a 27,8 ± 7,9 kg), masa magra (de 36,3 ± 0,4 a 37,4 ± 0,4 kg) e índice de masa muscular esquelética (de 6,0 ± 0,6 a 6,3 ± 0,6 kg/m²). Conclusiones: el tratamiento del HS tiene impacto sobre la composición corporal en sujetos mayores de 65

  15. Understanding vegetation response to climate variability from space the scientific objectives, the approach and the concept of the Spectra Mission

    NASA Astrophysics Data System (ADS)

    Menenti, M.; Rast, M.; Baret, F.; Hurk, B.; Knorr, W.; Mauser, W.; Miller, J.; Schaepman, M.; Schimel, D.; Verstraete, M.

    observations of the following variables: 1) Fractional vegetation cover; 2) Fraction Absorbed Photosynthetically Active Radiation (FAPAR); 3) Albedo; 4) Leaf Area Index (LAI); 5) Leaf chlorophyll content; 6)Leaf water content; 7) Foliage temperature; 8) Soil temperature; 9) Fractional cover of living and dead biomass. SPECTRA will provide spatially distributed observations (maps) of the key vegetation properties at the spatial resolution of one image pixel and a temporal frequency of one week or lower. Each map will cover an area of 50 km x 50 km. The SPECTRA mission is being studied by the European Space Agency to address these scientific issues. The mission comprises the following elements: A. Space segment consisting of an imaging spectrometer covering the region 400nm - 2400 nm with a nominal spectral resolution of 10 nm and of an agileplatform to perform subsequent, along track observations at seven view anglesbetween -70° and + 70°. B. Ground segment consisting of a core data processing facility and specializedCenters of Excellence to guarantee to a wide and diverse community access tohigher level data products and to specialized data assimilation systems. C. Field segment consisting of 50 to 100 dedicated sites where teams ofinvestigators evaluate the observations and assimilate them in models describingthe functio ning of terrestrial ecosystems.

  16. New Organic Stable Isotope Reference Materials for Distribution through the USGS and the IAEA

    NASA Astrophysics Data System (ADS)

    Schimmelmann, Arndt; Qi, Haiping

    2014-05-01

    the 10 laboratories. Successfully calibrated organic RMs could become available as early as 2015. - n-Hexadecane (C16 n-alkane), three H, C-isotopic varieties; - Glycine (amino acid), three H, C, N-isotopic varieties; - L-valine (amino acid), three H, C, N-isotopic varieties; - Methyl n-heptadecanoate (methyl ester of C17 n-alkanoic fatty acid); - Methyl icosanoate (methyl ester of C20 n-alkanoic fatty acid), three H, C-isotopic varieties; - Caffeine, three H, C, N-isotopic varieties; - Hydrocarbon vacuum pump oils, two H-isotopic varieties; - Polyethylene powder, and possibly a 2H and 13C-enriched polyethylene string. [1] Qi H., Coplen T.B., Geilmann H., Brand W.A., Böhlke J.K. (2003) Two new organic reference materials for δ13C and δ15N measurements and a new value for the δ13C of NBS 22 oil. Rapid Communications in Mass Spectrometry 17, 2483-2487. [2] Coplen T.B. (1996) New guidelines for reporting stable hydrogen, carbon, and oxygen isotope-ratio data. Geochimica et Cosmochimica Acta 60, 3359-3360. [3] Coplen T.B., Brand W.A., Gehre M., Gröning M., Meijer H.A.J., Toman B., Verkouteren R.M. (2006) New guidelines for δ13C measurements. Analytical Chemistry 78 (7), 2439-2441. [4] Werner R.A., Brand W.A. (2001) Referencing strategies and techniques in stable isotope ratio analysis. Rapid Communications in Mass Spectrometry 15, 501-519.

  17. Pions to Quarks

    NASA Astrophysics Data System (ADS)

    Brown, Laurie Mark; Dresden, Max; Hoddeson, Lillian

    2009-01-01

    Part I. Introduction; 1. Pions to quarks: particle physics in the 1950s Laurie M Brown, Max Dresden and Lillian Hoddeson; 2. Particle physics in the early 1950s Chen Ning Yang; 3. An historian's interest in particle physics J. L. Heilbron; Part II. Particle discoveries in cosmic rays; 4. Cosmic-ray cloud-chamber contributions to the discovery of the strange particles in the decade 1947-1957 George D. Rochester; 5. Cosmic-ray work with emulsions in the 1940s and 1950s Donald H. Perkins; Part III. High-energy nuclear physics; Learning about nucleon resonances with pion photoproduction Robert L. Walker; 7. A personal view of nucleon structure as revealed by electron scattering Robert Hofstadter; 8. Comments on electromagnetic form factors of the nucleon Robert G. Sachs and Kameshwar C. Wali; Part IV. The new laboratory; 9. The making of an accelerator physicist Matthew Sands; 10. Accelerator design and construction in the 1950s John P. Blewett; 11. Early history of the Cosmotron and AGS Ernest D. Courant; 12. Panel on accelerators and detectors in the 1950s Lawrence W. Jones, Luis W. Alvarez, Ugo Amaldi, Robert Hofstadter, Donald W. Kerst, Robert R. Wilson; 13. Accelerators and the Midwestern Universities Research Association in the 1950s Donald W. Kerst; 14. Bubbles, sparks and the postwar laboratory Peter Galison; 15. Development of the discharge (spark) chamber in Japan in the 1950s Shuji Fukui; 16. Early work at the Bevatron: a personal account Gerson Goldhaber; 17. The discovery of the antiproton Owen Chamberlain; 18. On the antiproton discovery Oreste Piccioni; Part V. The Strange Particles; 19. The hydrogen bubble chamber and the strange resonances Luis W. Alvarez; 20. A particular view of particle physics in the fifties Jack Steinberger; 21. Strange particles William Chinowsky; 22. Strange particles: production by Cosmotron beams as observed in diffusion cloud chambers William B. Fowler; 23. From the 1940s into the 1950s Abraham Pais; Part VI. Detection of the

  18. Hydrothermal processes above the Yellowstone magma chamber: Large hydrothermal systems and large hydrothermal explosions

    USGS Publications Warehouse

    Morgan, L.A.; Shanks, W.C. Pat; Pierce, K.L.

    2009-01-01

    Hydrothermal explosions are violent and dramatic events resulting in the rapid ejection of boiling water, steam, mud, and rock fragments from source craters that range from a few meters up to more than 2 km in diameter; associated breccia can be emplaced as much as 3 to 4 km from the largest craters. Hydrothermal explosions occur where shallow interconnected reservoirs of steam- and liquid-saturated fluids with temperatures at or near the boiling curve underlie thermal fields. Sudden reduction in confi ning pressure causes fluids to fl ash to steam, resulting in signifi cant expansion, rock fragmentation, and debris ejection. In Yellowstone, hydrothermal explosions are a potentially signifi cant hazard for visitors and facilities and can damage or even destroy thermal features. The breccia deposits and associated craters formed from hydrothermal explosions are mapped as mostly Holocene (the Mary Bay deposit is older) units throughout Yellowstone National Park (YNP) and are spatially related to within the 0.64-Ma Yellowstone caldera and along the active Norris-Mammoth tectonic corridor. In Yellowstone, at least 20 large (>100 m in diameter) hydrothermal explosion craters have been identifi ed; the scale of the individual associated events dwarfs similar features in geothermal areas elsewhere in the world. Large hydrothermal explosions in Yellowstone have occurred over the past 16 ka averaging ??1 every 700 yr; similar events are likely in the future. Our studies of large hydrothermal explosion events indicate: (1) none are directly associated with eruptive volcanic or shallow intrusive events; (2) several historical explosions have been triggered by seismic events; (3) lithic clasts and comingled matrix material that form hydrothermal explosion deposits are extensively altered, indicating that explosions occur in areas subjected to intense hydrothermal processes; (4) many lithic clasts contained in explosion breccia deposits preserve evidence of repeated fracturing

  19. The design of Janus, the visible camera for the ESA JUICE mission

    NASA Astrophysics Data System (ADS)

    Della Corte, Vincenzo; Schmitz, Nicole; Castro, José Maria; Leese, Mark; Debei, Stefano; Magrin, Demetrio; Michalik, Harald

    2014-05-01

    The JUICE (JUpiter ICy moons Explorer) mission was selected in May 2012 as the first Large mission in the frame of the ESA Cosmic Vision 2015-2025 program. The mission is aimed at an in-depth characterization of the Jovian system, with an operational phase of about 3.5 years. During the whole operational phase, JANUS (Jovis, Amorum ac Natorum Undique Scrutator) will acquire panchromatic and narrow-band images in the visible - NIR range of many targets within the Jovian system: the Galilean satellites surfaces and exospheres, Jupiter atmosphere, minor and irregular satellites, the ring system. After a long trade-off between different design solutions, based on performance requirements, mission design and constraints, the present JANUS design has been based on the following architectural choices detailed below. A catoptric telescope with excellent optical quality is coupled with a framing CMOS detector, avoiding any scan-ning mechanism or operational requirement on the S/C. The three mirror anastigmatic (TMA) off-axis design with F#=4.67 allows an MTF between 62% and 72% at Nyquist, with good straylight rejection. The detector is the CIS115 from e2v; it is a CMOS with a squared 7 micron pixel pitch and image format of 2000x1504. It performs a high readout rate of up to 40 Mpixel/s, high quantum efficiency and low readout noise and dark signal. Fine tuning of instrument parameters allows to perform both high resolution targeted observations and lower resolution global coverage of targets, as required to meet science objectives. The IFoV (Fieldo of View per pixel) is 15 microrad, al-lowing sampling of 7.5 m/pixel from 500 km and 15 km/pixel from 10E6 km, while the FoV is 1.72x1.29 deg. The acquisition parameters allow to cope with the many different observation requirements and conditions that JANUS will face. Design of the two electronics units (a proximity electronics controlling the detector and a main electronics controlling the instrument and the interfaces with

  20. [Study of tolerance and aceptability of a hyperproteic enteral formula enriched in fiber].

    PubMed

    De Luis, Daniel Antonio; Izaola, Olatz; Castro, A; Martin, M; Torres, B; Lopez Gomez, Jj; Gomez Hoyos, E; Blanco Naveira, Mercedes

    2014-10-18

    ,44 ± 0,78, rango: 0 a 3) (p=0,035). En ningún caso se observaron complicaciones digestivas relacionadas con la fórmula o con su administración, ni se reportaron acontecimientos adversos relacionados con la nutrición. Conclusiones: Isosource Protein® Fibre® ha mostrado ser una fórmula de nutrición enteral bien tolerada, con una baja frecuencia de síntomas gastrointestinales y una mejoría en el número de deposiciones, lo que favorece el cumplimiento de la pauta prescrita por el profesional de la salud y sugiere un efecto positivo en la regulación del tránsito intestinal.

  1. [Use of leflunomide in a cytomegalovirus infection resistant: a report of a case].

    PubMed

    Gómez Valbuena, Isabel; Alioto, Daniel; Serrano Garrote, Olga; Ferrari Piquero, Jose Miguel

    2016-01-01

    leflunomida, aunque sin respuesta, ya que en marzo del 2015, al inicio del tratamiento con leflunomida, la paciente presentaba una carga viral de 17.344 UI/ml. La pauta inicial fue de 100 mg de leflunomida al día durante los cinco primeros días, seguida de 20 mg cada 12 horas. A los quince días de tratamiento la carga viral había disminuido hasta 531 UI/ml, volviéndose indetectable antes del mes. Después de cuatro meses de tratamiento, la paciente mantiene la carga viral indetectable sin presentar ningún efecto adverso asociado al mismo. Conclusión: nuestro caso es un ejemplo en el que el uso de leflunomida en infección por CMV resistentes a otras terapias es una alternativa eficaz y conveniente para los pacientes, ya que mantiene indetectable la carga viral con una terapia oral, sin necesidad de ingresar en el hospital para tratamiento intravenoso.

  2. The Successful Implementation of NASA Orbital Debris Requirements for the Retirement of TDRS-1

    NASA Technical Reports Server (NTRS)

    Mirczak, Walter; Staich, Steve; Vaught, Lynn; Zaleski, Ronald

    2010-01-01

    TDRS-1 was decommissioned on October 28th 2009 following more than 26 years of operation. The Grand Old Dame of the TDRSS constellation wa s launched aboard the maiden voyage of the Space Shuttle Challenger ( STS-6) in April 1983. TDRS-1 survived a malfunction of the Inertial Upper Stage eventually utilizing its own propulsion system to success fully reach its assigned station in geosynchronous orbit. The anomalo us beginning of the TDRS-1 mission was not without lasting consequenc es as the primary reaction control system (A-side) was completely di sabled with an apparent propellant leak and the secondary system (B-s ide) suffered damage to its negative roll thruster rendering the thru ster inoperable. Following decommissioning the challenge to completin g a successful TDRS-1 end-of-mission (EOM) was the implementation of the stringent orbital debris requirements of NPR 8715.6 with a parti ally functioning spacecraft not originally designed to meet those req uirements. The TDRS-1 EOM had three key goals: 1) removal of the spac ecraft from geosynchronous orbit; 2) depletion of the remaining prope llant; and 3) passivation of all other sources of energy storage or generation. The TDRS-1 EOM approach was one of minimizing risks while accomplishing the goals above. The orbit raising portion of EOM was accomplished using deltavelocity operations already proven during pre vious stationchanging maneuvers. The propellant depletion approach wa s necessarily more aggressive as over 20 hours of burn time was requ ired to deplete the remaining fuel. A novel approach utilizing a spin ning, thrusting, passively controlled spacecraft configuration was ut ilized to achieve reasonable burn durations that met schedule constra ints. This nonstandard configuration required careful analysis of ele ctrical, thermal, and communication subsystems. The configuration wa s thoroughly simulated prior to the start of operations and carefully characterized during the initial spin period and

  3. EDITORIAL: Focus on Graphene

    NASA Astrophysics Data System (ADS)

    Peres, N. M. R.; Ribeiro, Ricardo M.

    2009-09-01

    lattice models and quantum spin chains Mahdi Zarea and Nancy Sandler On the universal ac optical background in graphene V P Gusynin, S G Sharapov and J P Carbotte Heat conduction in graphene: experimental study and theoretical interpretation S Ghosh, D L Nika, E P Pokatilov and A A Balandin Calculation of the Raman G peak intensity in monolayer graphene: role of Ward identities D M Basko Electronic transport in bilayer graphene Mikito Koshino Magnetic Kronig-Penney model for Dirac electrons in single-layer graphene M Ramezani Masir, P Vasilopoulos and F M Peeters Electrical transport in high-quality graphene pnp junctions Jairo Velasco Jr, Gang Liu, Wenzhong Bao and Chun Ning Lau Local density of states and scanning tunneling currents in graphene N M R Peres, Ling Yang and Shan-Wen Tsai Gaps and tails in graphene and graphane B Dóra and K Ziegler Quasi-ferromagnet spintronics in the graphene nanodisc-lead system Motohiko Ezawa Range and correlation effects in edge disordered graphene nanoribbons Alessandro Cresti and Stephan Roche Remarks on the tight-binding model of graphene Cristina Bena and Gilles Montambaux

  4. Inner-ear decompression sickness: 'hubble-bubble' without brain trouble?

    PubMed

    Tremolizzo, Lucio; Malpieri, Massimo; Ferrarese, Carlo; Appollonio, Ildebrando

    2015-06-01

    Inner-ear decompression sickness (DCS) is an incompletely understood and increasingly recognized condition in compressed-air divers. Previous reports show a high association of inner-ear DCS with persistent foramen ovale (PFO), suggesting that a moderate-to-severe right-to-left shunt might represent a major predisposing factor, and more properly defining it as an event from arterial gas embolism (AGE). However, other conditions characterized by bubbles entering the arterial circulation, such as open-chamber cardiac surgery, do not produce inner-ear involvement, while sometimes damaging the brain extensively. Moreover, in other sites, such as the spinal cord, the prevailing mechanism for DCS is not AGE, but more likely local bubble formation with subsequent compression of venules and capillaries. Thus, AGE might be, more properly, a predisposing condition, neither sufficient, nor possibly even strictly necessary for inner-ear DCS. A 'two-hit hypothesis' has been proposed, implying a locally selective vulnerability of the inner ear to AGE. Modelled kinetics for gas removal are slower in the inner ear compared to the brain, leading to a supersaturated environment which allows bubbles to grow until they eventually obstruct the labyrinthine artery. Since this artery is relatively small, there is a low probability for a bubble to enter it; this might explain the disproportion between the high prevalence of PFO in the general population (25-30%) and the very low incidence of inner-ear DCS in compressed-air diving (approximately 0.005%). Furthermore, given that the labyrinthine artery usually originates either from the anterior inferior cerebellar artery, or directly from the basilar artery, shunting bubbles will more frequently swarm through the entire brain. In this case, however, the brain's much faster gas removal kinetics might allow for them to be reabsorbed without damaging brain tissue. In line with this scenario is the low probability (approx. 15%) of inner

  5. [Adverse effects with ambulatory intravenous immunoglobulin administration in adult patients with common variable immunodeficiency].

    PubMed

    Rodríguez-Mireles, Karen A; Galguera-Sauceda, Angélica; Gaspar-López, Arturo; López-Rocha, Eunice G; Campos-Romero, Freya; Del Rivero-Hernández, Leonel; Amaya-Mejía, Adela; Galindo-Pacheco, Lucy; O'Farril-Romanillos, Patricia; Segura-Méndez, Nora Hilda

    2014-01-01

    en 25 pacientes con diagnóstico de inmunodeficiencia común variable (15 mujeres y 10 varones, con edad promedio de 36.7 años), durante un periodo de 10 meses (enero a septiembre de 2013). En este periodo se aplicaron 284 infusiones de IgIV utilizando el esquema propuesto, la frecuencia de reacciones adversas fue de 12.9% del total de las infusiones, de las que 5.2% fueron reacciones adversas tempranas y 7.7% reacciones adversas tardías, todas fueron reacciones leves a moderadas, que ameritaron en algunos casos la administración de analgésico, antihistamínico o ambos, sin llegar a requerirse la suspensión de la infusión de IgIV. En el estudio de la función renal se incluyeron 19 pacientes (12 mujeres y 7 hombres, edad promedio 36 años, peso promedio 58.74 kg y talla promedio 1.60 m) y en el lapso estudiado (enero de 2009 a octubre de 2013) la determinación de creatinina en promedio fue de 0.76 ± 0.18 mg/dL; la urea sérica promedio del grupo fue de 28.6 ± 7.6 mg/dL, ningún paciente tuvo datos de insuficiencia renal aguda. La tasa de filtración glomerular se determinó mediante la fórmula de CKD-EPI y fue, en promedio, de 116 ± 34 mL/min/1.73 m2, se encontraron datos de deterioro renal crónico en cuatro pacientes. La determinación promedio de la depuración de creatinina en orina de 24 horas fue de 98.64 ± 22 mL/min/1.73 m2 y se encontraron datos de deterioro crónico en la función renal en seis pacientes. Conclusiones: con este esquema ambulatorio de aplicación de IgIV no hubo reacciones adversas graves (anafilaxia, broncoespasmo, insuficiencia renal aguda). En esta población de pacientes no se encontró afección renal aguda secundaria a la aplicación de IgIV, pero mediante la depuración de creatinina de 24 horas sí se encontraron datos que sugirieron daño renal crónico en seis pacientes. No se encontró relación entre la dosis acumulada de IgIV aplicada en los últimos cinco años con el hallazgo de disminución de la tasa de filtraci

  6. A review of eating disorders research in Mexico.

    PubMed

    Unikel, Claudia; Bojorquez, Ietza

    2007-02-01

    indizadas y tesis de grado, mediante los descriptores "trastorno alimentario," anorexia nervosa," bulimia nervosa," "imagen corporal," "atracones," "restricción alimentaria," "preocupación por el peso y la figura," y "conducta de dieta." Éstos se combinaron con el operador Booleano "AND" con "México" y "América Latina." Se presentan los hallazgos para la epidemiología, la validez de los instrumentos de medición, comorbilidad, y factores de riesgo. Una encuesta nacional representativa encontró una prevalencia de 1.8% para la bulimia nervosa, y ningún caso de anorexia nervosa. No obstante, la carencia de estudios con una entrevista clínica confirmatoria y de otras muestras nacionales o regionales dificulta el arribo a conclusiones acerca de la prevalencia real. Varios instrumentos para la detección de los trastornos alimentarios y de la alimentación desordenada se han validado en población mexicana. La comorbilidad de los trastornos alimentarios en México incluye el uso y abuso de alcohol, la obesidad y el trastorno de personalidad limítrofe. Los factores de riesgo referidos incluyen el peso corporal y la presión cultural para estar delgado. Las líneas de investigación futuras deberán incluir estudios epidemiológicos con muestras representativas y la confirmación del diagnóstico, estudios longitudinales, y la exploración de factores de riesgo y protectores específicos a esta población. L'objectif de cet article est de résumer les résultats de recherche et l'état actuel des connaissances sur les troubles alimentaires au Mexique. Les articles publiés dans des revues indexées et les thèses de doctorat ont été recensés en utilisant les mots-clés « eating disorders », « anorexia nervosa », « bulimia nervosa », « body image », « binge eating », « restrained eating », « weight and shape concern » et « dieting ». Ceux-ci furent combinés, en utilisant la conjonction « AND », avec les termes « Mexico » et « Latin America ». Les

  7. Tanque Loma, a new late-Pleistocene megafaunal tar seep locality from southwest Ecuador

    NASA Astrophysics Data System (ADS)

    Lindsey, Emily L.; Lopez R., Eric X.

    2015-01-01

    , geologic context, and sedimentology of Tanque Loma suggest that this site represents a bone bed assemblage in a heavily vegetated, low-energy riparian environment with secondary infiltration of asphalt that helped to preserve the bones. The predominance of Eremotherium fossils at this site indicate that it may have been an area where these animals congregated, suggesting possible gregarious behavior in this taxon. The radiocarbon dates so far obtained on extinct taxa at Tanque Loma are consistent with a model positing earlier extinctions of megafauna in tropical South America than of related taxa further south on the continent, although this pattern may be an artifact of low sampling in the region. xml:lang="es" Aunque más de 1.000 huesos de megafauna han sido identificados en los estratos del Pleistoceno en Tanque Loma, más del 85% de esos mismos pertenecen a una sola especie, el perezoso gigante Eremotherium laurillardi. Sin embargo, otros cinco taxones de megafauna han sido recuperados de este sitio, los cuales son: Glossotherium cf. G. tropicorum, Holmesina occidentalis, cf. Notiomastodon platensis, Equus (Amerhippus) c.f. santaelenae y un cérvido identificado tentativamente en base a tamaño y geografía como cf. Odocoileus salinae. Ningún carnívoro ha sido identificado aún en Tanque Loma, y los restos de microvertebrados son muy raros en los estratos del Pleistoceno, aunque las conchas de caracol terrestre y los restos fragmentados de invertebrados marinos son encontrados ocasionalmente dentro de esas capas. Los fechados de radiocarbono por espectrómetro de acelerador de masas (AMS) en huesos de Eremotherium y cf. Notiomastodon de la capa de asfalto y por encima de esta resultaron en ˜17,000-23,500 años radiocarbónicos AP. En conjunto, la tafonomía, la composición taxonómica, el contexto geológico, y la sedimentolgía del sitio Tanque Loma surgieren que esta localidad representa un yacimiento depositado en un ambiente ribereño con bajo flujo y vegetaci

  8. EDITORIAL: 'Best article' prize for the 5th anniversary of Environmental Research Letters 'Best article' prize for the 5th anniversary of Environmental Research Letters

    NASA Astrophysics Data System (ADS)

    Kammen, Dan; Wright, Guillaume

    2011-12-01

    To celebrate the 5th anniversary of Environmental Research Letters (ERL) the publishers of the journal, IOP Publishing, have awarded a prize for the five best articles published in ERL since the journal began in 2006. The procedure for deciding the winning articles was as thorough as possible to ensure that the most outstanding articles would win the prize. A shortlist of 25 nominated research articles, five for each year since ERL was launched, which were chosen based on a range of criteria including novelty, scientific impact, readership, broad appeal and wider media coverage, was selected. The ERL Editorial Board then assessed and rated these 25 articles in order to choose a winning article for each year. We would like to announce that the following articles have been awarded ERL's 5th anniversary best article prize: 2006/7 The Bodélé depression: a single spot in the Sahara that provides most of the mineral dust to the Amazon forest Ilan Koren, Yoram J Kaufman, Richard Washington, Martin C Todd, Yinon Rudich, J Vanderlei Martins and Daniel Rosenfeld 2006 Environ. Res. Lett. 1 014005 2008 Causes and impacts of the 2005 Amazon drought Ning Zeng, Jin-Ho Yoon, Jose A Marengo, Ajit Subramaniam, Carlos A Nobre, Annarita Mariotti and J David Neelin 2008 Environ. Res. Lett. 3 014002 2009 How difficult is it to recover from dangerous levels of global warming? J A Lowe, C Huntingford, S C B Raper, C D Jones, S K Liddicoat and L K Gohar 2009 Environ. Res. Lett. 4 014012 2010 Is physical water scarcity a new phenomenon? Global assessment of water shortage over the last two millennia Matti Kummu, Philip J Ward, Hans de Moel and Olli Varis 2010 Environ. Res. Lett. 5 034006 2011 Implications of urban structure on carbon consumption in metropolitan areas Jukka Heinonen and Seppo Junnila 2011 Environ. Res. Lett. 6 014018 Our congratulations go to these authors. In recognition of their outstanding work, we are delighted to offer all of the authors of the winning articles free

  9. EDITORIAL: Focus on Quantum Correlations in Tailored Matter

    NASA Astrophysics Data System (ADS)

    Muramatsu, Alejandro; Pfau, Tilman

    2008-04-01

    different experimental realizations leading to the two routes mentioned above, they share a common goal, namely achieving a deep understanding of quantum correlations that will ultimately allow to control them and possibly realize new forms of matter. They also share the flexibility that allows to increase the complexity in quantum correlations by joining in a controlled manner well understood building units and/or by regulating their coupling to the environment. It is under the common goal of understanding and controlling quantum correlations that we see the topics presented in this focus issue of New Journal of Physics, where both lines of development, that is on solid-state substrates or with quantum gases, give a timely view of the advances towards the above mentioned common goal. Focus on Quantum Correlations in Tailored Matter Contents Temperature changes when adiabatically ramping up an optical lattice Lode Pollet, Corinna Kollath, Kris Van Houcke and Matthias Troyer Numerical study of two-body correlation in a 1D lattice with perfect blockade B Sun and F Robicheaux Kinetic Monte Carlo modeling of dipole blockade in Rydberg excitation experiment Amodsen Chotia, Matthieu Viteau, Thibault Vogt, Daniel Comparat and Pierre Pillet Motion of Rydberg atoms induced by resonant dipole-dipole interactions C Ates, A Eisfeld and J M Rost Quantum coherence due to Bose-Einstein condensation of parametrically driven magnons S O Demokritov, V E Demidov, O Dzyapko, G A Melkov and A N Slavin Chaotic dynamics in spinor Bose-Einstein condensates J Kronjäger, K Sengstock and K Bongs Damped Bloch oscillations of Bose-Einstein condensates in disordered potential gradients S Drenkelforth, G Kleine Büning, J Will, T Schulte, N Murray, W Ertmer, L Santos and J J Arlt Rabi oscillations between ground and Rydberg states and van der Waals blockade in a mesoscopic frozen Rydberg gas M Reetz-Lamour, J Deiglmayr, T Amthor and M Weidemüller Excitations in two-component Bose gases A Kleine, C

  10. A pilot study of the efficacy of wipes containing chlorhexidine 0.3%, climbazole 0.5% and Tris-EDTA to reduce Malassezia pachydermatis populations on canine skin

    PubMed Central

    Cavana, Paola; Peano, Andrea; Petit, Jean-Yanique; Tizzani, Paolo; Perrot, Sébastien; Bensignor, Emmanuel; Guillot, Jacques

    2015-01-01

    -EDTA contre Malassezia pachydermatis. Sujets Cinq colonies de shar-pei de recherche. Méthodes Les lingettes ont été appliquées une fois par jour au niveau du pli axillaire gauche, le pli inguinal droit et de la zone périanale(protocole A) et deux fois par joursur le pli axillaire droit, le inguinal droit et l'ombilic (protocole B) pendant 3 jours. L'activité in vivo a été évaluée par quantification des colonies de Malassezia par disques de contact sur les zones corporelles choisies avant et après application des lingettes. L'activité de la solution d'imprégnation des lingettes a été testée in vitro par tests de contact suivant les recommandations de l'European Standard UNI EN 1275. Résultats Les échantillons prélevés après application ont montré une diminution importante et rapide des CFU des levures Malassezia. Aucune différence significative dans la diminution des Malassezia n'a été mise en évidence entre les protocoles A et B. Des tests in vitro ont montré 100% d'activité contre les Malassezia après un temps de contact de 15 minutes avec la solution des lingettes. Conclusions et importance Clinique Les lingettes contenant la chlorhexidine, le climbazole et le Tris-EDTA réduisent substantiellement la population de M. pachydermatis sur la peau des chiens. Les résultats, bien qu'il s'agisse d'une étude non contrôlée réalisée sur un faible nombre de chiens, suggère que ces lingettes peuvent être utiles en traitement local de la dermatite à Malassezia des lèvres, des pattes, du périnée et des plis cutanés. Resumen Introducción las gasas que contienen clorhexidina y derivados de azol son recomendadas para uso veterinario. No se ha publicado ningún estudio acerca su actividad contra Malassezia paquidermatis. Hipótesis/Objetivos evaluar la actividad in vivo e in vitro de las gasas con clorhexidina, climbazol y soluciónb Tris-EDTA frente a Malassezia pachydermatis Animales cinco colonias de investigación de perros Sharpei. M

  11. Advanced Materials and Processing 2010

    NASA Astrophysics Data System (ADS)

    Zhang, Yunfeng; Su, Chun Wei; Xia, Hui; Xiao, Pengfei

    2011-06-01

    Strain sensors made from MWNT/polymer nanocomposites / Gang Yin, Ning Hu and Yuan Li -- Shear band evolution and nanostructure formation in titanium by cold rolling / Dengke Yang, Peter D. Hodgson and Cuie Wen -- Biodegradable Mg-Zr-Ca alloys for bone implant materials / Yuncang Li ... [et al.] -- Hydroxyapatite synthesized from nanosized calcium carbonate via hydrothermal method / Yu-Shiang Wu, Wen-Ku Chang and Min Jou -- Modeling of the magnetization process and orthogonal fluxgate sensitivity of ferromagnetic micro-wire arrays / Fan Jie ... [et al.] -- Fabrication of silicon oxide nanowires on Ni coated silicon substrate by simple heating process / Bo Peng and Kwon-Koo Cho -- Deposition of TiOxNy thin films with various nitrogen flow rate: growth behavior and structural properties / S.-J. Cho ... [et al.] -- Observation on photoluminescence evolution in 300 KeV self-ion implanted and annealed silicon / Yu Yang ... [et al.] -- Facile synthesis of lithium niobate from a novel precursor H[symbol] / Meinan Liu ... [et al.] -- Effects of the buffer layers on the adhesion and antimicrobial properties of the amorphous ZrAlNiCuSi films / Pai-Tsung Chiang ... [et al.] -- Fabrication of ZnO nanorods by electrochemical deposition process and its photovoltaic properties / Jin-Hwa Kim ... [et al.] -- Cryogenic resistivities of NbTiAlVTaLax, CoCrFeNiCu and CoCrFeNiAl high entropy alloys / Xiao Yang and Yong Zhang -- Modeling of centrifugal force field and the effect on filling and solidification in centrifugal casting / Wenbin Sheng, Chunxue Ma and Wanli Gu -- Electrochemical properties of TiO[symbol] nanotube arrays film prepared by anodic oxidation / Young-Jin Choi ... [et al.] -- Effect of Ce additions on high temperature properties of Mg-5Sn-3Al-1Zn alloy / Byoung Soo Kang ... [et al.] -- Sono-electroless plating of Ni-Mo-P film / Atsushi Chiba, Masato Kanou and Wen-Chang Wu -- Diameter dependence of giant magneto-impedance effect in co-based melt extracted amorphous

  12. EDITORIAL: Special Issue on advanced and emerging light sources Special Issue on advanced and emerging light sources

    NASA Astrophysics Data System (ADS)

    Haverlag, Marco; Kroesen, Gerrit; Ferguson, Ian

    2011-06-01

    ' discharge light sources and (O)LED sources, and new concepts are still being added to the range of technologies that are being used in practice. A truly classic aspect of lamp operation is lumen maintenance, and despite being in use for almost 50 years, Na/Sc quartz metal halide lamps until recently still suffered from a strong lumen depreciation over life. This issue has been resolved to a large extent with the introduction of high-frequency operation. In the paper of Van Erk et al, indications are given as to why this mode of operation is so successful. Another classic theme in the area of discharge lamp sources is ignition, still a major issue. In two consecutive papers by Sobota et al, several aspects of the cold ignition of ceramic metal halide lamps are discussed, including statistical delay effects, the role of the driving voltage, and ignition aids. The ignition becomes more complex when mercury is left out of a metal halide lamp and this is clearly shown in the paper by Estupiñán et al. When not buffered by mercury, water impurities will give rise to the formation of hydrogen iodide, which is very volatile and a strongly electronegative species, thereby hampering the ignition process. Mercury-free metal halide lamps will potentially show very different spectral properties. This is shown in the paper by Käning et al, where use has been made of the ongoing improvements in ceramic lamp technology to make lamps with a high rare-earth iodide content. It was found that in such lamps the contribution of molecular lines can become so important that some lines even become self-reversed. This opens new possibilities for making high-quality white light sources without mercury while retaining the use of electrodes. High rare-earth content also changes the behaviour of electrodes as a result of the lowering of the work function due to gas-phase emitter effects. In the paper by Reinelt et al some clear examples of this effect are investigated as well as their dependence on