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Sample records for hotel sekonomit na

  1. 57. VIEW LOOKING NORTH OF DENNIS HOTEL. BLENHEIM HOTEL IS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    57. VIEW LOOKING NORTH OF DENNIS HOTEL. BLENHEIM HOTEL IS PARTLY VISABLE TO THE RIGHT; SHELBOURNE HOTEL IS PARTLY VISABLE TO THE LEFT - Marlborough, Blenheim & Dennis Hotels (aerial views), Between Park Place, Michigan Avenue & Boardwalk, Atlantic City, Atlantic County, NJ

  2. 54. VIEW LOOKING NORTHEAST AT DENNIS HOTEL, BLENHEIM HOTEL AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    54. VIEW LOOKING NORTHEAST AT DENNIS HOTEL, BLENHEIM HOTEL AND MARLBOROUGH HOTEL (LEFT TO RIGHT) - Marlborough, Blenheim & Dennis Hotels (aerial views), Between Park Place, Michigan Avenue & Boardwalk, Atlantic City, Atlantic County, NJ

  3. 66. VIEW LOOKING NORTH AT THE MARLBOROUGH HOTEL. BLENHEIM HOTEL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    66. VIEW LOOKING NORTH AT THE MARLBOROUGH HOTEL. BLENHEIM HOTEL IS PARTIALLY VIASBLE TO THE LEFT. CLARIDGE HOTEL IS VISABLE TO THE RIGHT - Marlborough, Blenheim & Dennis Hotels (aerial views), Between Park Place, Michigan Avenue & Boardwalk, Atlantic City, Atlantic County, NJ

  4. 41. VIEW LOOKING NORTHWEST AT THE DENNIS HOTEL, BLENHEIM HOTEL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    41. VIEW LOOKING NORTHWEST AT THE DENNIS HOTEL, BLENHEIM HOTEL AND MARLBOROUGH HOTEL (LEFT TO RIGHT). CLARIDGE HOTEL IS PARTLY VISABLE TO THE RIGHT - Marlborough, Blenheim & Dennis Hotels (aerial views), Between Park Place, Michigan Avenue & Boardwalk, Atlantic City, Atlantic County, NJ

  5. The Infinite Hotel

    ERIC Educational Resources Information Center

    Wanko, Jeffrey J.

    2009-01-01

    This article provides a historical context for the debate between Georg Cantor and Leopold Kronecker regarding the cardinality of different infinities and incorporates the short story "Welcome to the Hotel Infinity," which uses the analogy of a hotel with an infinite number of rooms to help explain this concept. Wanko makes use of this history and…

  6. Crime wave in hotels.

    PubMed

    1998-04-01

    A National Development and Research Institutes study of New York's residential hotels, housing 400 AIDS patients, found rampant criminal activity. The 113-page report, commissioned by Mayor Guiliani, found prostitution, loan sharking, extortion, and theft to be commonplace, some of it perpetrated by hotel managers and employees. The unsafe conditions force some residents to miss medical treatments or drug rehabilitation because they are afraid to leave their rooms.

  7. 1. EAST FACADE OF THE MARCUS DALY HOTEL. THE HOTEL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. EAST FACADE OF THE MARCUS DALY HOTEL. THE HOTEL WAS CONSTRUCTED IN A U SHAPE, WITH THE ENTRANCE ARCADE FORMING THE FORTH SIDE OF THE RECTANGLE - Anaconda Historic District, Marcus Daly Hotel, 200-208 Main Street, Anaconda, Deer Lodge County, MT

  8. 52. VIEW LOOKING EAST WITH THE MARLBOROUGH HOTEL, BLENHEIM HOTEL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    52. VIEW LOOKING EAST WITH THE MARLBOROUGH HOTEL, BLENHEIM HOTEL AND THE DENNIS HI=OTEL (TOP TO BOTTOM) IN THE CENTER OF THE PHOTOGRAPH - Marlborough, Blenheim & Dennis Hotels (aerial views), Between Park Place, Michigan Avenue & Boardwalk, Atlantic City, Atlantic County, NJ

  9. Cogeneration for resort hotels

    SciTech Connect

    Baker, T.D.

    1986-01-01

    Resort Hotels should be considered for application of co-generation to take advantage of higher thermal efficiency and consequent energy cost avoidance. Modern resort hotels require comfort and reliability from mechanical and electrical systems on an around the clock basis. Load profiling reveals simultaneous process heating and electricity use requirements that aid in the selection and sizing of co-generation equipment. Resort Hotel needs include electrical loads for lighting, fan motors, elevators, escalators and receptacle uses. Process heat demands arise from kitchen, servery, banquet, restaurant, laundry, and bakery functions. Once the loads requiring service have been quantified and realigned (shifted) to maximize simultaneous demands the engineering task of co-generation application becomes one of economics. National legislation is now in place to foster the use of co-generating central utility plants. Serving utility companies are now by law required to buy back excess energy during periods of reduced hotel demands. Resort Hotel loads, converted into electricity and heat demands are tabulated in terms of savings (positive cash flow) or costs (negative cash flows). Cash flow tabulations expressed in graphs are included. The graphs show the approximate simple payback on initial costs of co-generation systems based on varying electricity charges.

  10. Quantum Hilbert Hotel

    NASA Astrophysics Data System (ADS)

    Potoček, Václav; Miatto, Filippo M.; Mirhosseini, Mohammad; Magaña-Loaiza, Omar S.; Liapis, Andreas C.; Oi, Daniel K. L.; Boyd, Robert W.; Jeffers, John

    2015-10-01

    In 1924 David Hilbert conceived a paradoxical tale involving a hotel with an infinite number of rooms to illustrate some aspects of the mathematical notion of "infinity." In continuous-variable quantum mechanics we routinely make use of infinite state spaces: here we show that such a theoretical apparatus can accommodate an analog of Hilbert's hotel paradox. We devise a protocol that, mimicking what happens to the guests of the hotel, maps the amplitudes of an infinite eigenbasis to twice their original quantum number in a coherent and deterministic manner, producing infinitely many unoccupied levels in the process. We demonstrate the feasibility of the protocol by experimentally realizing it on the orbital angular momentum of a paraxial field. This new non-Gaussian operation may be exploited, for example, for enhancing the sensitivity of NOON states, for increasing the capacity of a channel, or for multiplexing multiple channels into a single one.

  11. Quantum Hilbert Hotel.

    PubMed

    Potoček, Václav; Miatto, Filippo M; Mirhosseini, Mohammad; Magaña-Loaiza, Omar S; Liapis, Andreas C; Oi, Daniel K L; Boyd, Robert W; Jeffers, John

    2015-10-16

    In 1924 David Hilbert conceived a paradoxical tale involving a hotel with an infinite number of rooms to illustrate some aspects of the mathematical notion of "infinity." In continuous-variable quantum mechanics we routinely make use of infinite state spaces: here we show that such a theoretical apparatus can accommodate an analog of Hilbert's hotel paradox. We devise a protocol that, mimicking what happens to the guests of the hotel, maps the amplitudes of an infinite eigenbasis to twice their original quantum number in a coherent and deterministic manner, producing infinitely many unoccupied levels in the process. We demonstrate the feasibility of the protocol by experimentally realizing it on the orbital angular momentum of a paraxial field. This new non-Gaussian operation may be exploited, for example, for enhancing the sensitivity of NOON states, for increasing the capacity of a channel, or for multiplexing multiple channels into a single one. PMID:26550858

  12. [Deaths in hotels].

    PubMed

    Risse, Manfred; Weilbächer, Nadine; Birngruber, Christoph; Verhoff, Marcel A

    2010-01-01

    There are no verified statistics about deaths occurring in hotels, and only a few cases have been described in the literature. A recent case induced us to conduct a systematic search for deaths in hotels in the autopsy reports of the Institute of Legal Medicine in Giessen for the period from 1968 to 2009. This search yielded 22 evaluable cases in which persons had been found dead or had died in hotels. Data evaluated in the study were sex and age of the deceased, reason for the stay in the hotel and cause of death. Among the deaths, 18 were males and 4 females and the average age was 41 and 40 years respectively. 6 of the male guests had died from a natural and 10 from a non-natural cause. In the remaining two cases, the cause of death could not be determined, but as there was no evidence that another party had been involved, the cases were not further investigated. Of the 4 female guests, 3 had died of a natural cause; in one case, the cause of death remained unclear even after morphological and toxicological investigations. Surprisingly, a third of the men were found to be temporarily living in hotels due to social circumstances. This was not true for any of the women. Our retrospective analysis is based on a comparatively small number of deaths in what were mostly hotels in small to medium-sized towns. Interestingly, the gender ratio of 18:4 for deceased men and women was significantly higher than the usual gender ratio of 2:1 found for forensic autopsies. To be able to draw further conclusions, a greater number of cases would have to be analysed, for example by recruiting additional case files from other institutes of legal medicine. This would also open up the option of investigating possible regional variations.

  13. 27 CFR 31.82 - Hotels.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Hotels. 31.82 Section 31... Same Premises § 31.82 Hotels. The proprietor of a hotel who conducts the sale of liquors throughout the hotel premises is only required to register under this part for one place. For example, different...

  14. 27 CFR 31.82 - Hotels.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Hotels. 31.82 Section 31... Same Premises § 31.82 Hotels. The proprietor of a hotel who conducts the sale of liquors throughout the hotel premises is only required to register under this part for one place. For example, different...

  15. 27 CFR 31.82 - Hotels.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Hotels. 31.82 Section 31... Same Premises § 31.82 Hotels. The proprietor of a hotel who conducts the sale of liquors throughout the hotel premises is only required to register under this part for one place. For example, different...

  16. 27 CFR 31.82 - Hotels.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Hotels. 31.82 Section 31... Same Premises § 31.82 Hotels. The proprietor of a hotel who conducts the sale of liquors throughout the hotel premises is only required to register under this part for one place. For example, different...

  17. 27 CFR 31.82 - Hotels.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Hotels. 31.82 Section 31... Same Premises § 31.82 Hotels. The proprietor of a hotel who conducts the sale of liquors throughout the hotel premises is only required to register under this part for one place. For example, different...

  18. Agency-Hired Hotel Housekeepers

    PubMed Central

    Sanon, Marie-Anne V.

    2014-01-01

    Hotel housekeepers experience unique workplace hazards and characteristics that increase their risks for poor health outcomes. Today’s agency-hiring practices may further marginalize hotel housekeepers and negatively impact their health. Yet the impact of such hiring practices on the health of this vulnerable worker group remains unexplored. This article presents the debate regarding agency-hiring practices and how these practices may influence the health and well-being of hotel housekeepers. Implications for occupational health nurses are also discussed. PMID:24512722

  19. Towards Universal Design Hotels in Denmark.

    PubMed

    Grangaard, Sidse

    2016-01-01

    Based on the research project 'Accessible Hotel Rooms' that studies the balance between the experience of supply and demand regarding accessibility features in Danish hotel rooms, this paper demonstrates factors having an influence on Universal Design hotels in Denmark. The research project was financed by the Danish Transport and Construction Agency. Different notions in the hotel sector of the current supply and demand for Universal Design hotel rooms are identified, as well as future demand. Despite supplying accessible rooms, some hotels do not advertise their accessibility features on their website. There exists an attitude in the hotel sector that functions as a barrier for Universal Design: if there are enough guests, for example business travellers, then why market the hotel on Universal Design? The paper points out the coherence between the understanding of the users and the view of demand. Another important factor is Corporate Social Responsibility, which can be regarded as a strategy or platform towards Universal Design hotels.

  20. Towards Universal Design Hotels in Denmark.

    PubMed

    Grangaard, Sidse

    2016-01-01

    Based on the research project 'Accessible Hotel Rooms' that studies the balance between the experience of supply and demand regarding accessibility features in Danish hotel rooms, this paper demonstrates factors having an influence on Universal Design hotels in Denmark. The research project was financed by the Danish Transport and Construction Agency. Different notions in the hotel sector of the current supply and demand for Universal Design hotel rooms are identified, as well as future demand. Despite supplying accessible rooms, some hotels do not advertise their accessibility features on their website. There exists an attitude in the hotel sector that functions as a barrier for Universal Design: if there are enough guests, for example business travellers, then why market the hotel on Universal Design? The paper points out the coherence between the understanding of the users and the view of demand. Another important factor is Corporate Social Responsibility, which can be regarded as a strategy or platform towards Universal Design hotels. PMID:27534313

  1. 27. VIEW LOOKING NORTH AT ROOFS OF DENNIS HOTEL AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    27. VIEW LOOKING NORTH AT ROOFS OF DENNIS HOTEL AND BLENHEIM HOTEL. MARLBOROUGH HOTEL IS PARTLY VISIBLE TO THE RIGHT - Marlborough, Blenheim & Dennis Hotels (aerial views), Between Park Place, Michigan Avenue & Boardwalk, Atlantic City, Atlantic County, NJ

  2. 6. VIEW LOOKING NORTH TO NORTHEAST OF DENNIS HOTEL, BLENHEIM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. VIEW LOOKING NORTH TO NORTHEAST OF DENNIS HOTEL, BLENHEIM HOTEL AND MARLBOROUGH HOTEL (LEFT TO RIGHT) IN THE CENTER OF THE PHOTO - Marlborough, Blenheim & Dennis Hotels (aerial views), Between Park Place, Michigan Avenue & Boardwalk, Atlantic City, Atlantic County, NJ

  3. Hotels Make Room for Fitness.

    ERIC Educational Resources Information Center

    Koszuta, Laurie Einstein

    1986-01-01

    Hotels, in hopes of gaining a competitive edge, are offering workout rooms, exercise equipment, fitness trails, and jogging tracks, but no standards have been set for safety of the facilities or staff preparedness in exercise screening, equipment use, injury prevention, or first aid. (MT)

  4. 4. photocopy of an advertisement (from Penn Alto Hotel archives, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. photocopy of an advertisement (from Penn Alto Hotel archives, Altoona, Pennsylvania) ADVERTISEMENT TO SELL STOCK IN PENN ALTO HOTEL - Penn Alto Hotel, 1120-1130 Thirteenth Avenue, Altoona, Blair County, PA

  5. 33. VIEW LOOKING NORTHNORTHWEST AT THE DENNIS HOTEL (PARTIAL VIEW ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    33. VIEW LOOKING NORTH-NORTHWEST AT THE DENNIS HOTEL (PARTIAL VIEW OF THE BLENHEIM HOTEL) - Marlborough, Blenheim & Dennis Hotels (aerial views), Between Park Place, Michigan Avenue & Boardwalk, Atlantic City, Atlantic County, NJ

  6. 43. VIEW LOOKING WEST AT THE MARLBOROUGH HOTEL WITH THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    43. VIEW LOOKING WEST AT THE MARLBOROUGH HOTEL WITH THE BLENHEIM, DENNIS,AND SHELBOURNE HOTELS BEYOUND - Marlborough, Blenheim & Dennis Hotels (aerial views), Between Park Place, Michigan Avenue & Boardwalk, Atlantic City, Atlantic County, NJ

  7. 39. VIEW LOOKING NORTHNORTHEAST AT THE MARLBOROUGH HOTEL WITH THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    39. VIEW LOOKING NORTH-NORTHEAST AT THE MARLBOROUGH HOTEL WITH THE BLENHEIM HOTEL IN THE BACKGROUND - Marlborough, Blenheim & Dennis Hotels (aerial views), Between Park Place, Michigan Avenue & Boardwalk, Atlantic City, Atlantic County, NJ

  8. CONTEXTUAL VIEW FROM HOTEL; HAMILTON BUNGALOW IN FOREGROUND; BUNGALOW NO. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CONTEXTUAL VIEW FROM HOTEL; HAMILTON BUNGALOW IN FOREGROUND; BUNGALOW NO. 3 DIRECTLY BEHIND; HINDS & CONNER AND "A" BUNGALOWS IN REAR. VISTA DEL ARROYO HOTEL ON RIGHT - Vista del Arroyo Hotel, 125 South Grand Avenue, Pasadena, Los Angeles County, CA

  9. 1. General view of the Moody Hotel, Tremont Square. The ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. General view of the Moody Hotel, Tremont Square. The hotel was built by William Emerson in 1890-92. - Claremont Village Industrial District, Moody Hotel, Tremont Square, Claremont, Sullivan County, NH

  10. 88. VIEW LOOKING FROM THE BRIDGE FROM THE MARLBOROUGH HOTEL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    88. VIEW LOOKING FROM THE BRIDGE FROM THE MARLBOROUGH HOTEL TOWARD THE READING LOUNGE OUTSIDE OF THE MAIN DINING ROOM OF THE BLENHEIM HOTEL - Blenheim Hotel, Ohio Avenue & Boardwalk, Atlantic City, Atlantic County, NJ

  11. 3. photocopy of an advertisement (from Penn Alto Hotel archives, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. photocopy of an advertisement (from Penn Alto Hotel archives, Altoona, Pennsylvania) ADVERTISEMENT TO SELL STOCK IN PENN ALTO HOTEL - Penn Alto Hotel, 1120-1130 Thirteenth Avenue, Altoona, Blair County, PA

  12. Fireguard Training for Hotel Employees: Sprinkler Module.

    ERIC Educational Resources Information Center

    Mason, James

    This thesis examines the analysis, design, development, implementation, and evaluation of an instructional development project addressing hotel fireguards. Systematic techniques were applied to produce a session to train the appropriate hotel employees to qualify as fireguards. The portion of training represented in this report is the sprinkler…

  13. Promotion of responsible drinking in hotels.

    PubMed

    McLean, S; Wood, L J; Montgomery, I M; Davidson, J; Jones, M E

    1994-01-01

    This study reports on an intervention programme to promote responsible drinking in hotels. The licensees of eight hotels agreed to participate in a trial of measures designed to assist patrons to avoid drink-driving, and seven other hotels were used as controls. The interventions acceptable to licensees comprised commercial-quality promotional material with the theme "0.05 Know Your Limits", and a breath analysis machine and poster on its use. Patrons leaving the hotels on Thursday, Friday and Saturday nights were interviewed and breath-tested. Although the intervention material had been seen by one-third of patrons in the intervention hotels, there was no significant difference between them and control hotel patrons in either median BAC or the proportion who were going to drive with BAC over the legal limit. There was poor compliance by hotels with the intervention procedures, indicating that a major impediment to the implementation and evaluation of programmes to promote responsible drinking is a lack of motivation by many licensees, despite support by some licensees and the Australian Hotels Association.

  14. Hotel Housekeeping Work Influences on Hypertension Management

    PubMed Central

    Sanon, Marie-Anne

    2013-01-01

    Background Characteristics of hotel housekeeping work increase the risk for hypertension development. Little is known about the influences of such work on hypertension management. Methods For this qualitative study, 27 Haitian immigrant hotel housekeepers from Miami-Dade County, FL were interviewed. Interview transcripts were analyzed with the assistance of the Atlas. ti software for code and theme identification. Results Influences of hotel housekeeping work on hypertension management arose both at the individual and system levels. Factors at the individual level included co-worker dynamics and maintenance of transmigrant life. Factors at the system level included supervisory support, workload, work pace, and work hiring practices. No positive influences were reported for workload and hiring practices. Conclusions Workplace interventions may be beneficial for effective hypertension management among hotel housekeepers. These work influences must be considered when determining effective methods for hypertension management among hotel housekeepers. PMID:23775918

  15. 30. VIEW LOOKING NORTH AT DENNIS HOTEL SOUTH ELEVATION. BLENHEIM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    30. VIEW LOOKING NORTH AT DENNIS HOTEL SOUTH ELEVATION. BLENHEIM HOTEL SOUTH ELEVATION IS PARTIALLY VISIBLE TO THE RIGHT. SHELBOURNE HOTEL IS PARTIALLY VISIBLE TO THE LEFT - Marlborough, Blenheim & Dennis Hotels (aerial views), Between Park Place, Michigan Avenue & Boardwalk, Atlantic City, Atlantic County, NJ

  16. Smoke management system considerations for hotel atriums

    SciTech Connect

    Dillon, M.E.

    1983-07-01

    This article examines the many life safety problems inherent in open balcony atriums, particularly those in hotels. Focuses on the smoke-management system of a hotel, and shows what can be achieved by an architect, an owner, a building department and a fire department that works together to achieve an enhanced level of life safety in the building's construction. Emphasizes that the hotel should be fully sprinklered; that it have carefully thought-out detection and alarm systems; that it have a reliably engineered smoke management system; and that it be routinely inspected and maintained. Discusses life safety concerns, smoke extraction, and failure mode analysis.

  17. Geography Matters in Online Hotel Reviews

    NASA Astrophysics Data System (ADS)

    Wang, Mingshu; Zhou, Xiaolu

    2016-06-01

    In resonance with the popularity of user-generated contents (UGC) and the volunteered geographic information (VGI), this study crowdsourced 77,098 hotel reviews of 220 hotels provided by U.S. reviewers in the city of San Francisco, 2002 to 2015. In this exploratory analysis, we have revealed that there is spatial dependence of customer satisfaction at different locations (of hotels), which violates the assumption that ordinary least-square (OLS) is the best linear unbiased estimator (BLUE); therefore, spatial model might be required for analysing any antecedents and consequences of such phenomena. These results have implications in marketing and management strategies.

  18. The homeless: help from hotels and restaurants.

    PubMed

    Hales, A; Eyster, J J; Ford, J L

    1993-07-01

    Specific examples and information are given to service providers to address the needs of homeless people. Together nurses and restaurant and hotel managers combined their expertise to assist local agencies in their community kitchens and shelters.

  19. Spinning reserve from hotel load response

    SciTech Connect

    Kirby, Brendan; Kueck, John; Laughner, Theo; Morris, Keith

    2008-12-15

    Even though preliminary tests were not conducted during times of highest system or hotel loading during the summer, they showed that hotel load can be curtailed by 22 to 37 percent depending on the outdoor temperature and time of day. Full response occurred in 12 to 60 seconds from when the system operator's command to shed load was issued and the load drop was very rapid. (author)

  20. Detail, Scandia Hotel, view to southwest showing details of balloon ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Detail, Scandia Hotel, view to southwest showing details of balloon framing, including full two-story studs notched to carry girts supporting second story floor joists (210mm lens) - Scandia Hotel, 225 First Street, Eureka, Humboldt County, CA

  1. 40 CFR 30.18 - Hotel and motel fire safety.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Hotel and motel fire safety. 30.18... EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Pre-Award Requirements § 30.18 Hotel and motel fire safety. The Hotel and Motel Fire Safety Act of 1990 (Public Law 101-391) establishes a number of...

  2. 40 CFR 30.18 - Hotel and motel fire safety.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Hotel and motel fire safety. 30.18... EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Pre-Award Requirements § 30.18 Hotel and motel fire safety. The Hotel and Motel Fire Safety Act of 1990 (Public Law 101-391) establishes a number of...

  3. 40 CFR 30.18 - Hotel and motel fire safety.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Hotel and motel fire safety. 30.18... EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Pre-Award Requirements § 30.18 Hotel and motel fire safety. The Hotel and Motel Fire Safety Act of 1990 (Public Law 101-391) establishes a number of...

  4. 40 CFR 30.18 - Hotel and motel fire safety.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Hotel and motel fire safety. 30.18... EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Pre-Award Requirements § 30.18 Hotel and motel fire safety. The Hotel and Motel Fire Safety Act of 1990 (Public Law 101-391) establishes a number of...

  5. Hotel Employees' Japanese Language Experiences: Implications and Suggestions.

    ERIC Educational Resources Information Center

    Makita-Discekici, Yasuko

    1998-01-01

    Analyzes the Japanese language learning experiences of 13 hotel employees in Guam. Results of the study present implications and suggestions for a Japanese language program for the hotel industry. The project began as a result of hotel employees frustrations when they were unable to communicate effectively with their Japanese guests. (Auth/JL)

  6. 40 CFR 30.18 - Hotel and motel fire safety.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Hotel and motel fire safety. 30.18... EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Pre-Award Requirements § 30.18 Hotel and motel fire safety. The Hotel and Motel Fire Safety Act of 1990 (Public Law 101-391) establishes a number of...

  7. Jebel Ali Hotel PV lighting systems

    SciTech Connect

    Ellis, M.

    1984-05-01

    A large stand-alone PV lighting project was installed in June 1983 at the Jebel Ali Hotel in Dubai, United Arab Emirates. A high mast lighting system provides illumination for a 130 meter diameter traffic roundabout. The high mast system is powered by a 15 kilowatt peak array of Mobil Solar ribbon PV modules. Along the 700 meter access road leading to the hotel entrance, twenty-one PV powered streetlights provide low-level lighting. Each streetlight consists of a 20 watt fluorescent tube powered by two 35 Wp modules. Operation of both systems is completely automatic. Design, installation, and operating experience to date are reviewed.

  8. The Application of Intelligent Building Technologies to Space Hotels

    NASA Astrophysics Data System (ADS)

    Fawkes, S.

    This paper reports that over the last few years Intelligent Building technologies have matured and standardised. It compares the functions of command and control systems in future large space facilities such as space hotels to those commonly found in Intelligent Buildings and looks at how Intelligent Building technologies may be applied to space hotels. Many of the functions required in space hotels are the same as those needed in terrestrial buildings. The adaptation of standardised, low cost, Intelligent Building technologies would reduce capital costs and ease development of future space hotels. Other aspects of Intelligent Buildings may also provide useful models for the development and operation of space hotels.

  9. Smoking in hotels: prevalence, and opinions about restrictions.

    PubMed

    Semmonds, A; Bailey, K; Bentley, S; Chase, V; Fernando, S; Guruge, A; King, M; Tan, O M; Walsh, R

    1995-02-01

    Exposure to high levels of environmental tobacco smoke can occur in hotels. Controversy exists about smoking regulation on licensed premises. This survey of 138 people attending one of three Newcastle hotels during 1993 found that 57 per cent of respondents were nonsmokers. Fifty-eight per cent (95 per cent confidence interval (CI) 50 to 66 per cent) of respondents in these hotels believed their health was being adversely affected by other people's smoke in the hotel. Seventy per cent (CI 62 to 78 per cent), including half the smokers, were in favour of restriction of smoking in the hotels. Most preferred the establishment of smoke-free areas to the introduction of total smoking bans in hotels. The failure of hotels to regulate smoking suggests that a legislative approach is required. The case for legislation would be strengthened by a larger study elsewhere in Australia.

  10. Women in the Hotel and Catering Industry.

    ERIC Educational Resources Information Center

    Hotel and Catering Training Board, Wembley (England).

    A study of the employment of women in the hotel and catering industry indicated that the industry employs nearly 17 percent of the entire paid female work force in the United Kingdom. Women constitute 75 percent of the industry's work force, and 47 percent of its managers are women. Women's position in the industry is characterized by their…

  11. Chronic disease risk factors among hotel workers

    PubMed Central

    Gawde, Nilesh Chandrakant; Kurlikar, Prashika R.

    2016-01-01

    Context: Non-communicable diseases have emerged as a global health issue. Role of occupation in pathogenesis of non-communicable diseases has not been explored much especially in the hospitality industry. Aims: Objectives of this study include finding risk factor prevalence among hotel workers and studying relationship between occupational group and chronic disease risk factors chiefly high body mass index. Settings and Design: A cross-sectional study was conducted among non-managerial employees from classified hotels in India. Materials and Methods: The study participants self-administered pre-designed pilot-tested questionnaires. Statistical analysis used: The risk factor prevalence rates were expressed as percentages. Chi-square test was used for bi-variate analysis. Overweight was chosen as ‘outcome’ variable of interest and binary multi-logistic regression analysis was used to identify determinants. Results: The prevalence rates of tobacco use, alcohol use, inadequate physical activity and inadequate intake of fruits and vegetables were 32%, 49%, 24% and 92% respectively among hotel employees. Tobacco use was significantly common among those in food preparation and service, alcohol use among those in food service and security and leisure time physical activity among front office workers. More than two-fifths (42.7%) were overweight. Among the hotel workers, those employed in food preparation and security had higher odds of 1.650 (CI: 1.025 – 2.655) and 3.245 (CI: 1.296 – 8.129) respectively of being overweight. Conclusions: Prevalence of chronic disease risk factors is high among hotel workers. Risk of overweight is significantly high in food preparation and security departments and workplace interventions are necessary to address these risks PMID:27390474

  12. Legionellosis Outbreak Associated With a Hotel Fountain

    PubMed Central

    Smith, Shamika S.; Ritger, Kathy; Samala, Usha; Black, Stephanie R.; Okodua, Margaret; Miller, Loretta; Kozak-Muiznieks, Natalia A.; Hicks, Lauri A.; Steinheimer, Craig; Ewaidah, Saadeh; Presser, Lance; Siston, Alicia M.

    2015-01-01

    Background. In August 2012, the Chicago Department of Public Health (CDPH) was notified of acute respiratory illness, including 1 fatality, among a group of meeting attendees who stayed at a Chicago hotel during July 30–August 3, 2012. Suspecting Legionnaires' disease (LD), CDPH advised the hotel to close their swimming pool, spa, and decorative lobby fountain and began an investigation. Methods. Case finding included notification of individuals potentially exposed during July 16–August 15, 2012. Individuals were interviewed using a standardized questionnaire. An environmental assessment was performed. Results. One hundred fourteen cases were identified: 11 confirmed LD, 29 suspect LD, and 74 Pontiac fever cases. Illness onsets occurred July 21–August 22, 2012. Median age was 48 years (range, 22–82 years), 64% were male, 59% sought medical care (15 hospitalizations), and 3 died. Relative risks for hotel exposures revealed that persons who spent time near the decorative fountain or bar, both located in the lobby were respectively 2.13 (95%, 1.64–2.77) and 1.25 (95% CI, 1.09–1.44) times more likely to become ill than those who did not. Legionella pneumophila serogroup 1 was isolated from samples collected from the fountain, spa, and women's locker room fixtures. Legionella pneumophila serogroup 1 environmental isolates and a clinical isolate had matching sequence-based types. Hotel maintenance records lacked a record of regular cleaning and disinfection of the fountain. Conclusions. Environmental testing identified Legionella in the hotel's potable water system. Epidemiologic and laboratory data indicated the decorative fountain as the source. Poor fountain maintenance likely created favorable conditions for Legionella overgrowth. PMID:26716104

  13. Isolation of Legionella pneumophila from hotels of Greece.

    PubMed

    Alexiou, S D; Antoniadis, A; Papapaganagiotou, J; Stefanou, T

    1989-03-01

    Twenty water samples collected from 6 hotels situated in various areas of Greece were examined for the presence of Legionella pneumophila and Legionella-like organisms. Five of the six hotels included in this investigation were associated with cases of legionellosis. Legionella pneumophila serogroups 1 and 8 were isolated from four of six hotels, mainly from the hot water supply system. This is the first isolation and identification of L. pneumophila in Greece.

  14. Chinese hotel general managers' perspectives on energy-saving practices

    NASA Astrophysics Data System (ADS)

    Zhu, Yidan

    As hotels' concern about sustainability and budget-control is growing steadily, energy-saving issues have become one of the important management concerns hospitality industry face. By executing proper energy-saving practices, previous scholars believed that hotel operation costs can decrease dramatically. Moreover, they believed that conducting energy-saving practices may eventually help the hotel to gain other benefits such as an improved reputation and stronger competitive advantage. The energy-saving issue also has become a critical management problem for the hotel industry in China. Previous research has not investigated energy-saving in China's hotel segment. To achieve a better understanding of the importance of energy-saving, this document attempts to present some insights into China's energy-saving practices in the tourist accommodations sector. Results of the study show the Chinese general managers' attitudes toward energy-saving issues and the differences among the diverse hotel managers who responded to the study. Study results indicate that in China, most of the hotels' energy bills decrease due to the implementation of energy-saving equipments. General managers of hotels in operation for a shorter period of time are typically responsible for making decisions about energy-saving issues; older hotels are used to choosing corporate level concerning to this issue. Larger Chinese hotels generally have official energy-saving usage training sessions for employees, but smaller Chinese hotels sometimes overlook the importance of employee training. The study also found that for the Chinese hospitality industry, energy-saving practices related to electricity are the most efficient and common way to save energy, but older hotels also should pay attention to other ways of saving energy such as water conservation or heating/cooling system.

  15. HVAC systems and energy conservation in hotels

    SciTech Connect

    Wagner, J.R.

    1986-01-01

    This paper discusses the effect that the design of the basic HVAC has on the relative success of energy conservation efforts in hotels. The unusual nature of a hotel is explained along with the impact that it has on the HVAC system. The paper stresses the practical considerations which must be made by the HVAC system designer when he designs the guest rooms, public areas, back-of-the-house areas, temperature control system, and energy management system. The advantages of providing separate air-handling systems are presented. The benefits of line voltage electric controls for guest room fan coil units are explained. General recommendations for arrangement of ventilation systems and possible opportunities for heat recovery are included.

  16. Renovation And Modernization Of Hotel Buildings - Case Studies In Silesia

    NASA Astrophysics Data System (ADS)

    Bradecki, Tomasz; Uherek-Bradecka, Barbara

    2015-12-01

    The cultural heritage of Silesia has different backgrounds and is often characterized by difficult to assess values. There is doubt as to whether some of the existing buildings should be modernized. Since 2000, an increase in the amount of investments in hotel buildings and conference venues in Poland has been observed. The functions and roles of hotels within a city have also changed. The paper presents examples of original projects and realizations of hotel buildings in Silesia. A discussion was also held regarding the issue of adapting and modernizing hotel buildings.

  17. Hotel-Motel Occupations: Hotel-Motel Clerk. Front Office Manager. Competency-Based Education Curriculum.

    ERIC Educational Resources Information Center

    McKinney, L. S.

    A teacher's guide and student curriculum are provided for a hotel-motel occupations competency-based education curriculum designed to facilitate the learning of skills for front office clerks and managers. The teacher's guide contains an explanation of the curriculum and suggested usage, a list of competencies by job title, evaluation aids,…

  18. Management Trainees in the Hotel Industry: What Do Managers Expect?

    ERIC Educational Resources Information Center

    Baum, Tom

    1991-01-01

    Comparison of a survey of 118 United Kingdom hotel managers (53 percent response) with a similar study of 75 U.S. managers found key differences reflecting the impact of cultures on management expectations. Significant similarities support development of an internationally transferable core curriculum for hotel management. (SK)

  19. HOTEL AND MOTEL HOUSEKEEPING AIDE, A SUGGESTED TRAINING PROGRAM.

    ERIC Educational Resources Information Center

    Office of Education (DHEW), Washington, DC.

    A LOCAL TRAINING PROGRAM TO PREPARE HOTEL AND MOTEL HOUSEKEEPING AIDES CAN BE DEVELOPED FROM RESOURCE MATERIAL IN THIS GUIDE. PROGRAM OBJECTIVES ARE TO PREPARE TRAINEES TO PERFORM THE JOBS INVOLVED IN KEEPING HOTEL OR MOTEL ROOMS CLEAN, TO FOLLOW CORRECT PROCEDURES IN USING EQUIPMENT AND SUPPLIES REQUIRED IN CARING FOR BEDROOMS AND BATHROOMS, AND…

  20. Hotel & Food Service Industries. Workforce & Workplace Literacy Series.

    ERIC Educational Resources Information Center

    BCL Brief, 1992

    1992-01-01

    This brief gives an overview of the topic of workplace literacy for the hotel and food service industries and lists program contacts. The following organizations operate employee basic skills programs for hotel and food service employees, provide technical assistance, or operate grant programs: Essential Skills Resource Center; Language Training…

  1. New Employment Forecasts. Hotel and Catering Industry 1988-1993.

    ERIC Educational Resources Information Center

    Measurement for Management Decision, Ltd., London (England).

    Econometric forecasting models were used to forecast employment levels in the hotel and catering industry in Great Britain through 1993 under several different forecasting scenarios. The growth in employment in the hotel and catering industry over the next 5 years is likely to be broadly based, both across income levels of domestic consumers,…

  2. VIEW LOOKING WEST TOWARD RESERVOIR HILL. THE SPRR HOTEL WAS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW LOOKING WEST TOWARD RESERVOIR HILL. THE SPRR HOTEL WAS LOCATED IN THE STRIPED AREA AT THE BOTTOM OF THE IMAGE, AND THE TRACK RAN BETWEEN THE HILL AND THE HOTEL. - Southern Pacific Railroad Water Settling Reservoir, Yuma Crossing, south bank of Colorado River at foot of Madison Avenue, Yuma, Yuma County, AZ

  3. Changing Occupational Profiles in the Hotel Industry: Case Studies in France, Italy and Spain. Synthesis Report.

    ERIC Educational Resources Information Center

    Gatti, Mario; Grazia Mereu, Maria; Tagliaferro, Claudio

    Changing occupational profiles in the hotel industry in France, Italy, and Spain were examined in case studies that included interviews with hotel managers, human resource managers, and individuals employed in hotel occupations identified as new or entailing new skills. The study focused on the following topics: (1) changes in the hotel industry…

  4. Hotel-motel fires: past and present

    SciTech Connect

    Blackmon, J.T. Jr.

    1982-04-23

    The Winecoff Hotel Fire in 1946 triggered a great deal of activities directed toward improving methods of survival should a guest be involved in fire. In the 36 years since that event a great deal has transpired. Building integrity, construction, maintenance, firefighting appliances, occupant self protection systems, emergency communications and controls have drastically improved. However, fires continue to plague the unwary traveler thus this commentary reviews how a guest can probably survive with advanced planning on his or her part. While self preservation is the first priority, one should be actively engaged in learning what is going on in the community so that they can assist the community in providing fire safe structures at their places of business and at the other facilities where guests to their communities can conduct business and relax.

  5. Structure-borne noise at hotels

    NASA Astrophysics Data System (ADS)

    Wilson, George Paul; Jue, Deborah A.

    2002-11-01

    Hotels present a challenging environment for building designers to provide suitable noise and vibration isolation between very incompatible uses. While many are familiar with ways to reduce traditional sources of airborne noise and vibration, structure-borne noise and vibration are often overlooked, often with costly repercussions. Structure-borne noise can be very difficult to pinpoint, and troubleshooting the sources of the vibration can be a tedious process. Therefore, the best approach is to avoid the problem altogether during design, with attention to the building construction, potential vibration sources, building uses and equipment locations. In this paper, the relationship between structure-borne vibration and noise are reviewed, typical vibration sources discussed (e.g., aerobic rooms, laundry rooms, mechanical equipment/building services, and subway rail transit), and key details and design guidance to minimize structure-borne noise provided.

  6. 7. FOURTH FLOOR, DETAIL OF HOTEL SOAP LINE TO WEST: ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. FOURTH FLOOR, DETAIL OF HOTEL SOAP LINE TO WEST: FERGUSON & HAAS AUTOMATIC WRAPPING MACHINE INSTALLED BY 1929 - Colgate & Company Jersey City Plant, Building No. B-15, 90-96 Greene Street, Jersey City, Hudson County, NJ

  7. 5. FOURTH FLOOR, HOTEL SOAP LINES TO NORTHWEST: PRESS (LEFT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. FOURTH FLOOR, HOTEL SOAP LINES TO NORTHWEST: PRESS (LEFT CENTER), MANUAL CUTTERS (CENTER, RIGHT CENTER) - Colgate & Company Jersey City Plant, Building No. B-15, 90-96 Greene Street, Jersey City, Hudson County, NJ

  8. Occupational Programs for the Restaurant/Hotel Business

    ERIC Educational Resources Information Center

    Hoenninger, Ronald W.; Riegel, Carl D.

    1978-01-01

    Describes the development of a Hotel and Restaurant Management Program, designed to provide career training, develop educational opportunities, and provide a forum through which the continuing education needs of the local hospitality industry could be assessed and evaluated. (TP)

  9. PERSPECTIVE VIEW LOOKING ALONG F STREET AT THE NORTH (HOTEL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PERSPECTIVE VIEW LOOKING ALONG F STREET AT THE NORTH (HOTEL MONACO ENTRANCE) FACADE - United States General Post Office, Between Seventh, Eighth, E, & F Streets, Northwest, Washington, District of Columbia, DC

  10. Research on the Hotel Image Based on the Detail Service

    NASA Astrophysics Data System (ADS)

    Li, Ban; Shenghua, Zheng; He, Yi

    Detail service management, initially developed as marketing programs to enhance customer loyalty, has now become an important part of customer relation strategy. This paper analyzes the critical factors of detail service and its influence on the hotel image. We establish the theoretical model of influencing factors on hotel image and propose corresponding hypotheses. We use applying statistical method to test and verify the above-mentioned hypotheses. This paper provides a foundation for further study of detail service design and planning issues.

  11. Spinning Reserve from Hotel Air Conditioning Load - SHORT VERSION

    SciTech Connect

    Kueck, John D; Kirby, Brendan J

    2008-01-01

    Even though preliminary tests were not conducted during times of highest system or hotel loading during the summer, they showed that hotel load can be curtailed by 22 to 37 percent depending on the outdoor temperature and time of day. Full response occurred in 12 to 60 seconds from when the system operator's command to shed load was issued and the load drop was very rapid.

  12. Hellish conditions at single-room occupancy hotels.

    PubMed

    Foley, D

    1998-08-01

    Poor conditions exist in many of the commercial single-room occupancy (SRO) hotels for people who are HIV-positive. Living conditions are unsanitary, brutal, and dangerous, and occupants often experience harassment from the hotel owners and staff. Many of the occupants are drug abusers or are mentally incapacitated, and therefore may not have the ability to secure better housing. The situation in the California Suites, an SRO in Manhattan, is described.

  13. Move to outpatient settings may boost medical hotels.

    PubMed

    Burns, J

    1992-06-01

    The shift of surgeries to outpatient settings could be healthy for medical hotels, those amenity-equipped facilities originally developed to ease patients out of costly acute-care beds. Because fewer hospitals have a pressing need to use such alternative lodging, some medical hotels are hoping to hitch their fortunes to the outpatient trade, keeping patients overnight after surgeries that don't require hospital admission.

  14. Legionella contamination in hot water of Italian hotels.

    PubMed

    Borella, Paola; Montagna, Maria Teresa; Stampi, Serena; Stancanelli, Giovanna; Romano-Spica, Vincenzo; Triassi, Maria; Marchesi, Isabella; Bargellini, Annalisa; Tatò, Daniela; Napoli, Christian; Zanetti, Franca; Leoni, Erica; Moro, Matteo; Scaltriti, Stefania; Ribera D'Alcalà, Gabriella; Santarpia, Rosalba; Boccia, Stefania

    2005-10-01

    A cross-sectional multicenter survey of Italian hotels was conducted to investigate Legionella spp. contamination of hot water. Chemical parameters (hardness, free chlorine concentration, and trace element concentrations), water systems, and building characteristics were evaluated to study risk factors for colonization. The hot water systems of Italian hotels were strongly colonized by Legionella; 75% of the buildings examined and 60% of the water samples were contaminated, mainly at levels of > or =10(3) CFU liter(-1), and Legionella pneumophila was the most frequently isolated species (87%). L. pneumophila serogroup 1 was isolated from 45.8% of the contaminated sites and from 32.5% of the hotels examined. When a multivariate logistic model was used, only hotel age was associated with contamination, but the risk factors differed depending on the contaminating species and serogroup. Soft water with higher chlorine levels and higher temperatures were associated with L. pneumophila serogroup 1 colonization, whereas the opposite was observed for serogroups 2 to 14. In conclusion, Italian hotels, particularly those located in old buildings, represent a major source of risk for Legionnaires' disease due to the high frequency of Legionella contamination, high germ concentration, and major L. pneumophila serogroup 1 colonization. The possible role of chlorine in favoring the survival of Legionella species is discussed.

  15. Legionella Contamination in Hot Water of Italian Hotels

    PubMed Central

    Borella, Paola; Montagna, Maria Teresa; Stampi, Serena; Stancanelli, Giovanna; Romano-Spica, Vincenzo; Triassi, Maria; Marchesi, Isabella; Bargellini, Annalisa; Tatò, Daniela; Napoli, Christian; Zanetti, Franca; Leoni, Erica; Moro, Matteo; Scaltriti, Stefania; Ribera D'Alcalà, Gabriella; Santarpia, Rosalba; Boccia, Stefania

    2005-01-01

    A cross-sectional multicenter survey of Italian hotels was conducted to investigate Legionella spp. contamination of hot water. Chemical parameters (hardness, free chlorine concentration, and trace element concentrations), water systems, and building characteristics were evaluated to study risk factors for colonization. The hot water systems of Italian hotels were strongly colonized by Legionella; 75% of the buildings examined and 60% of the water samples were contaminated, mainly at levels of ≥103 CFU liter−1, and Legionella pneumophila was the most frequently isolated species (87%). L. pneumophila serogroup 1 was isolated from 45.8% of the contaminated sites and from 32.5% of the hotels examined. When a multivariate logistic model was used, only hotel age was associated with contamination, but the risk factors differed depending on the contaminating species and serogroup. Soft water with higher chlorine levels and higher temperatures were associated with L. pneumophila serogroup 1 colonization, whereas the opposite was observed for serogroups 2 to 14. In conclusion, Italian hotels, particularly those located in old buildings, represent a major source of risk for Legionnaires' disease due to the high frequency of Legionella contamination, high germ concentration, and major L. pneumophila serogroup 1 colonization. The possible role of chlorine in favoring the survival of Legionella species is discussed. PMID:16204491

  16. Employment Prospects in the Hotel and Catering Trade: A Franco-American Comparison.

    ERIC Educational Resources Information Center

    Meriot, Sylvie-Anne

    2000-01-01

    In both France and the United States, restaurants remain the hotel and catering sector's main employer. In France, 25% of hotel and catering personnel are self-employers versus fewer than 5% in the United States; however, the growth of hotel and restaurant chains in France may eventually limit opportunities for creating an independent activity.…

  17. Ergonomics and accessibility for people with visual impairment in hotels.

    PubMed

    Dos Santos, Larissa Nascimento; de Carvalho, Ricardo José Matos

    2012-01-01

    This article presents a diagnosis of luxury or superior hotels in the city of Natal, located in the state of Rio Grande do Norte, in northeastern Brazil, in what concerns accessibility to the visually impaired. The main objective is to present the guiding principles to design actions and interventions that must be considered in the preparation or revision of technical standards and manuals of good practice in accessibility related to people with visual impairments who are hotel users. The survey showed that the hotels do not meet the normative indications of accessibility, their facilities are in-accessible (have prevented access) or of reduced accessibility and its employees are not prepared to provide adequate hospital services for people with visual impairment. It was concluded that some of the accessibility problems faced by people with visual impairments are also faced by people in general.

  18. Space-Hotel Early Bird - Visions for a Commercial Space Hotel

    NASA Astrophysics Data System (ADS)

    Amekrane, R.; Holze, C.; Apel, U.

    2002-01-01

    rachid.amekrane@astrium-space.com/Fax: +49 421 539-24801, cholze@zarm.uni-bremen.de/Fax: +49 421 218-7473, The International Space Station was planed for research purposes. In 2001 the first private man, Denis Tito,visited the ISS and the second private man, Mark Shuttleworth is following him. The gate towards the commercial utilization of manned space flight has been pushed open. Space pioneers as Wernher von Braun and Sir Arthur C. Clarke had the dream that one day a space station in earth orbit will host tourists. It is evident that the ISS is not designed to host tourists. Therefore the dream of the pioneers is still open. By asking the question "how should a space station should look like to host tourists?", the German Aerospace Society DGLR e.V. organized a contest under the patronage of Mr. Joerg Feustel-Buechl, the Director of Manned Spaceflight and Microgravity, European Space Agency (ESA) in April 2001. Because the definition and design of living space is the content of architecture the approach was to gather new ideas from young architects in cooperation with space experts. This contest was directed at students of architecture and the task set was to design a hotel for the earth orbit and to accommodate 220 guests. The contest got the name "Early Bird - Visions of a Space Hotel". The results and models of the student's work were shown in an exhibition in Hamburg/Germany, which was open to the public from September 19th till October 20th 2001. During the summer term of 2001 seventeen designs were completed. Having specialists, as volunteers, in the field of space in charge meant that it could be ensured that the designs reflected a certain possibility of being able to be realized. Within this interdisciplinary project both parties learned from each other. The 17 different designs were focused on the expectations and needs of a future space tourist. The designs are for sure not feasible today, but the designs are in that sense realistic that they could be

  19. Spinning Reserve From Hotel Load Response: Initial Progress

    SciTech Connect

    Kueck, John D; Kirby, Brendan J

    2008-11-01

    This project was motivated by the fundamental match between hotel space conditioning load response capability and power system contingency response needs. As power system costs rise and capacity is strained demand response can provide a significant system reliability benefit at a potentially attractive cost. At ORNL s suggestion, Digital Solutions Inc. adapted its hotel air conditioning control technology to supply power system spinning reserve. This energy saving technology is primarily designed to provide the hotel operator with the ability to control individual room temperature set-points based upon occupancy (25% to 50% energy savings based on an earlier study [Kirby and Ally, 2002]). DSI added instantaneous local load shedding capability in response to power system frequency and centrally dispatched load shedding capability in response to power system operator command. The 162 room Music Road Hotel in Pigeon Forge Tennessee agreed to host the spinning reserve test. The Tennessee Valley Authority supplied real-time metering equipment in the form of an internet connected Dranetz-BMI power quality meter and monitoring expertise to record total hotel load during both normal operations and test results. The Sevier County Electric System installed the metering. Preliminary testing showed that hotel load can be curtailed by 22% to 37% depending on the outdoor temperature and the time of day. These results are prior to implementing control over the common area air conditioning loads. Testing was also not at times of highest system or hotel loading. Full response occurred in 12 to 60 seconds from when the system operator s command to shed load was issued. The load drop was very rapid, essentially as fast as the 2 second metering could detect, with all units responding essentially simultaneously. Load restoration was ramped back in over several minutes. The restoration ramp can be adjusted to the power system needs. Frequency response testing was not completed. Initial

  20. Project EXCEL: Hotel Workers Literacy Enhancement Program. Final Performance Report.

    ERIC Educational Resources Information Center

    Career Resources Development Center, Inc., San Francisco, CA.

    Project EXCEL is a federally-funded workplace literacy program involving hotel enterprises in the San Francisco (California) Bay area. Its focus is on identification and instruction of literacy skills essential to job success for limited-English-proficient (LEP) workers. Training is intended to enable employees to understand written work orders,…

  1. Competency Needs in Irish Hotels: Employer and Graduate Perspectives

    ERIC Educational Resources Information Center

    Nolan, Ciara; Conway, Edel; Farrell, Tara; Monks, Kathy

    2010-01-01

    Purpose: The purpose of this study is to investigate hotel industry employers' expectations of, and satisfaction with, graduate competencies in comparison with graduate perceptions of what is required for their roles and their satisfaction with how well their education experience prepared them. Design/methodology/approach: The research involved a…

  2. Hotel found liable in firing of HIV-positive bartender.

    PubMed

    1997-03-01

    A Federal jury in the court of U.S. Magistrate Judge Leslie G. Foschio of the Western District of New York found the Buffalo [name removed] liable for more than $630,000 in damages to bartender [name removed], who was fired because of his HIV infection. The [name removed] unsuccessfully argued that [name removed] was terminated because of unfavorable performance reviews. The plaintiffs claimed that the [name removed] issued false citations for infractions of hotel rules and that these citations were only issued after hotel management determined that [name removed] was HIV-positive. Testimony showed that all relevant decision-making personnel at the hotel were aware that [name removed] was HIV-positive. The hotel failed to show that all but the personnel manager had a legitimate need to know about [name removed]'s HIV status. The jury awarded [name removed] $1,439,000 in damages. Foschio lowered the amount to $637,388 in damages and $133,705 in attorneys' fees. PMID:11364135

  3. 6. FOURTH FLOOR, DETAIL OF HOTEL SOAP LINE TO NORTH: ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. FOURTH FLOOR, DETAIL OF HOTEL SOAP LINE TO NORTH: AMERICAN CAR & FOUNDRY COMPANY MANUAL SOAP CUTTER INSTALLED 1932 (FOREGROUND); CONVEYORS; AND R.A. JONES & COMPANY HORIZONTAL PRESS INSTALLED 1931 (BACKGROUND) - Colgate & Company Jersey City Plant, Building No. B-15, 90-96 Greene Street, Jersey City, Hudson County, NJ

  4. 12. DETAIL OF REMOVED PLODDER (UPPER HALF) FROM HOTEL SOAP ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. DETAIL OF REMOVED PLODDER (UPPER HALF) FROM HOTEL SOAP LINE No. 6 STORED IN G BLOCK (HAER No. NJ-71-NN) - Colgate & Company Jersey City Plant, Building No. B-14, 54-58 Grand Street, Jersey City, Hudson County, NJ

  5. 13. DETAIL OF REMOVED PLODDER (LOWER HALF) FROM HOTEL SOAP ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. DETAIL OF REMOVED PLODDER (LOWER HALF) FROM HOTEL SOAP LINE No. 6 STORED IN G BLOCK (HAER No. NJ-71-NN) - Colgate & Company Jersey City Plant, Building No. B-14, 54-58 Grand Street, Jersey City, Hudson County, NJ

  6. Women's Path to Management in the Hotel and Catering Industry.

    ERIC Educational Resources Information Center

    Hotel and Catering Training Board, Wembley (England).

    A study examined the employment patterns of women working in the United Kingdom's hotel and catering industry and the opportunities for vocational education that would lead to careers in management. Sixty-four women from different sectors of the industry were interviewed (including women in senior and middle management and some still looking to be…

  7. ESL for Hotel/Hospitality Industry. Level: Beginner.

    ERIC Educational Resources Information Center

    Western Suffolk County Board of Cooperative Educational Services, Northport, NY.

    This document contains eight lesson plans for a beginning course in work-related English for non-English or limited-English speaking entry-level employees in the hotel and hospitality industry. Course objectives include the following: helping participants understand and use job-specific vocabulary; receive and understand job-related instructions;…

  8. Understanding Work-Family Spillover in Hotel Managers.

    PubMed

    Lawson, Katie M; Davis, Kelly D; Crouter, Ann C; O'Neill, John W

    2013-06-01

    The present study examined the experience of work-family spillover among 586 hotel managers (HMs) working in 50 full-service hotels throughout the U.S. Work-family spillover occurs when behaviors, moods, stresses, and emotions from work spill over into family. We first investigated which hotel managers were more likely to experience spillover and stressful work conditions based on their life circumstances (gender, parental status, age, decision-making latitude at work). Second, we investigated which work conditions (hours worked per week, organizational time expectations, emotional labor, and permeable boundaries) predicted more work-family spillover. Women, employees without children at home, and younger adults experienced the highest levels of negative work-family spillover. Work conditions, particularly organizational time expectations, put HMs at risk for experiencing more negative and less positive work-family spillover. The results provide evidence that modifying certain work conditions in the hotel industry may be helpful in improving the quality of HMs' jobs and retention. PMID:23888092

  9. Paperwork Plus: Literacy Materials for the Service Industry. Hotel Edition.

    ERIC Educational Resources Information Center

    Bond, Judith; McGill, Teresa

    The instructional materials are intended for use in teaching vocational English and English literacy to limited-English-speaking personnel in the hotel industry. They are designed for learners at three instructional levels, and address job-specific literacy tasks. An introductory section describes the materials and offers suggestions for…

  10. Residents' Coping Strategies in an Extended-Stay Hotel Home

    ERIC Educational Resources Information Center

    Lewinson, Terri

    2010-01-01

    Some families live in extended-stay hotels as a solution after housing displacement. This temporary accommodation provides a furnished home environment with resources such as a kitchenette, bed, heating/air conditioning, and room services with one payment that can be made weekly or monthly without a credit check or rent deposit. Despite these…

  11. Solar-Cooled Hotel in the Virgin Islands

    NASA Technical Reports Server (NTRS)

    Harber, H.

    1982-01-01

    Performance of solar cooling system is described in 21-page report. System provides cooling for public areas including ball rooms, restaurant, lounge, lobby and shops. Chilled water from solar-cooling system is also used to cool hot water from hotel's desalinization plant.

  12. Understanding Work-Family Spillover in Hotel Managers

    PubMed Central

    Lawson, Katie M.; Davis, Kelly D.; Crouter, Ann C.; O’Neill, John W.

    2013-01-01

    The present study examined the experience of work-family spillover among 586 hotel managers (HMs) working in 50 full-service hotels throughout the U.S. Work-family spillover occurs when behaviors, moods, stresses, and emotions from work spill over into family. We first investigated which hotel managers were more likely to experience spillover and stressful work conditions based on their life circumstances (gender, parental status, age, decision-making latitude at work). Second, we investigated which work conditions (hours worked per week, organizational time expectations, emotional labor, and permeable boundaries) predicted more work-family spillover. Women, employees without children at home, and younger adults experienced the highest levels of negative work-family spillover. Work conditions, particularly organizational time expectations, put HMs at risk for experiencing more negative and less positive work-family spillover. The results provide evidence that modifying certain work conditions in the hotel industry may be helpful in improving the quality of HMs’ jobs and retention. PMID:23888092

  13. Evaluation of internal noise methods for Hotelling observer models

    SciTech Connect

    Zhang Yani; Pham, Binh T.; Eckstein, Miguel P.

    2007-08-15

    The inclusion of internal noise in model observers is a common method to allow for quantitative comparisons between human and model observer performance in visual detection tasks. In this article, we studied two different strategies for inserting internal noise into Hotelling model observers. In the first strategy, internal noise was added to the output of individual channels: (a) Independent nonuniform channel noise, (b) independent uniform channel noise. In the second strategy, internal noise was added to the decision variable arising from the combination of channel responses. The standard deviation of the zero mean internal noise was either constant or proportional to: (a) the decision variable's standard deviation due to the external noise, (b) the decision variable's variance caused by the external noise, (c) the decision variable magnitude on a trial to trial basis. We tested three model observers: square window Hotelling observer (HO), channelized Hotelling observer (CHO), and Laguerre-Gauss Hotelling observer (LGHO) using a four alternative forced choice (4AFC) signal known exactly but variable task with a simulated signal embedded in real x-ray coronary angiogram backgrounds. The results showed that the internal noise method that led to the best prediction of human performance differed across the studied model observers. The CHO model best predicted human observer performance with the channel internal noise. The HO and LGHO best predicted human observer performance with the decision variable internal noise. The present results might guide researchers with the choice of methods to include internal noise into Hotelling model observers when evaluating and optimizing medical image quality.

  14. From Hotel to High School: Converting a Residential Hotel into a New Type of Senior High School. Report and Recommendations of the Concourse Plaza High School Planning Committee.

    ERIC Educational Resources Information Center

    Sasserath, Simpson

    This document reports the result of a 5-day meeting held to recommend the structural building adaptations and the curriculum organization necessary to the renovation of Concourse Plaza Hotel into a high school. According to the planning committee, the hotel has many features adaptable to a school, which would permit a meaningful departure from the…

  15. How Clean Are Hotel Rooms? Part II: Examining the Concept of Cleanliness Standards.

    PubMed

    Almanza, Barbara A; Kirsch, Katie; Kline, Sheryl Fried; Sirsat, Sujata; Stroia, Olivia; Choi, Jin Kyung; Neal, Jay

    2015-01-01

    Hotel room cleanliness is based on observation and not on microbial assessment even though recent reports suggest that infections may be acquired while staying in hotel rooms. Exploratory research in the first part of the authors' study was conducted to determine if contamination of hotel rooms occurs and whether visual assessments are accurate indicators of hotel room cleanliness. Data suggested the presence of microbial contamination that was not reflective of visual assessments. Unfortunately, no standards exist for interpreting microbiological data and other indicators of cleanliness in hotel rooms. The purpose of the second half of the authors' study was to examine cleanliness standards in other industries to see if they might suggest standards in hotels. Results of the authors' study indicate that standards from other related industries do not provide analogous criteria, but do provide suggestions for further research. PMID:26427263

  16. Winning cancer centre has 'hotel-like' quality.

    PubMed

    Baillie, Jonathan

    2009-04-01

    A "highly effective" three-way partnership between architects Anshen + Allen, the Newcastle upon Tyne Hospitals NHS Foundation Trust, and Laing O'Rourke, has created a non-institutional and welcoming new cancer treatment and renal services centre in Newcastle upon Tyne which, despite the gruelling nature of some of the therapies set to be offered, has a character and feel early users describe as "more like a four-star hotel" than a conventional healthcare facility. Jonathan Baillie reports. PMID:19452798

  17. Use of hygiene protocols to control the spread of viruses in a hotel.

    PubMed

    Sifuentes, Laura Y; Koenig, David W; Phillips, Ronnie L; Reynolds, Kelly A; Gerba, Charles P

    2014-09-01

    The goals of this study were to observe the spread of viruses in a hotel setting and to assess the effectiveness of a hygiene intervention in reducing their spread. Selected fomites in one hotel room were inoculated with bacteriophage ϕx-174, and fomites in a conference center within the same hotel were inoculated using bacteriophage MS2. Cleaning of the contaminated room resulted in the spread of viruses to other rooms by the housekeeping staff. Furthermore, viruses were transferred by hotel guests to the conference center and a communal kitchen area. Additionally, conference attendees transferred viruses from the conference center to their hotel rooms and a communal kitchen area. This study demonstrated how viruses can be spread throughout a hotel setting by both housekeepers and guests. A hygiene intervention, which included providing hand hygiene products and facial tissues to the guests and disinfecting solutions with disposable wipes to the housekeeping staff, was successful in reducing the spread of viruses between the hotel guest rooms and conference center. The hygiene intervention resulted in significantly reduced transfer of the ϕx-174 between the contaminated hotel room and other hotel rooms, communal areas, and the conference center (p = 0.02).

  18. Single-room occupancy hotels: possible solutions and alternatives.

    PubMed

    Foley, D

    1998-09-01

    New York City's Division of AIDS Services and Income Support (DASIS) places clients in economical, commercial residences in one of 33 hotels in the New York City area, termed single-room occupancy (SRO) hotels. There have been many problems with these hotels in terms of safety and health. One problem is how to enforce housing laws when city agencies have had drastic personnel cutbacks, and landlords are not held accountable for repairs and building conditions. Without a strategic plan to supplement SROs with necessary services, and a way to deal with homeless people with AIDS, it will be difficult to redeem the condition of SROs and lessen dependency on them as a long-term solution. The West Side SRO Law Project offers tips on how tenants in SROs can safeguard their rights and document their cases if they feel that their rights have been violated. Included is a resource list for legal help and emergency numbers for the Department of Buildings in New York City and the surrounding boroughs.

  19. The Hotel Payload, plans for the period 2003-2006

    NASA Astrophysics Data System (ADS)

    Hansen, Gudmund; Mikalsen, Per-Arne

    2003-08-01

    The cost and complexity of scientific experiments, carried by traditional sounding rocket payloads, are increasing. At the same time the scientific environment faces declining funding for this basic research. In order to meet the invitation from the science community, Andøya Rocket Range runs a programme for developing a sounding rocket payload, in order to achieve an inexpensive and cost-effective tool for atmosphere research and educational training. The Hotel Payload is a new technological payload concept in the sounding rocket family. By means of standardized mechanical structures and electronics, flexibility in data collection and transmission, roomy vehicles are affordable to most of the scientific research environments as well as for educational training. A complete vehicle - ready for installation of scientific experiments - is offered to the scientists to a fixed price. The fixed price service also includes launch services. This paper describes the Hotel Payload concept and its technology. In addition the three year plan for the development project is discussed. The opportunity of using the Hotel Payload as a platform for a collaborative triangle between research, education and industry is also discussed.

  20. Work Stress and Well-being in the Hotel Industry.

    PubMed

    O'Neill, John W; Davis, Kelly

    2011-06-01

    Employee stress is a significant issue in the hospitality industry, and it is costly for employers and employees alike. Although addressing and reducing stress is both a noble goal and is capable of resulting in expense reductions for employers, the nature and quantity of hospitality employee stress is not fully understood. The first aim of this study was to identify common work stressors in a sample of 164 managerial and hourly workers employed at 65 different hotels who were each interviewed for eight consecutive days. The two most common stressors were interpersonal tensions at work and overloads (e.g., technology not functioning). The second aim was to determine whether there were differences in the types and frequency of work stressors by job type (i.e., managers v. non-managers), gender, and marital status. Hotel managers reported significantly more stressors than hourly employees. There were no significant differences by gender or marital status. The third aim was to investigate whether the various stressors were linked to hotel employee health and work outcomes. More employee and coworker stressors were linked to more negative physical health symptoms. Also, interpersonal tensions at work were linked to lower job satisfaction and greater turnover intentions. PMID:23794780

  1. Work Stress and Well-being in the Hotel Industry

    PubMed Central

    O'Neill, John W.; Davis, Kelly

    2013-01-01

    Employee stress is a significant issue in the hospitality industry, and it is costly for employers and employees alike. Although addressing and reducing stress is both a noble goal and is capable of resulting in expense reductions for employers, the nature and quantity of hospitality employee stress is not fully understood. The first aim of this study was to identify common work stressors in a sample of 164 managerial and hourly workers employed at 65 different hotels who were each interviewed for eight consecutive days. The two most common stressors were interpersonal tensions at work and overloads (e.g., technology not functioning). The second aim was to determine whether there were differences in the types and frequency of work stressors by job type (i.e., managers v. non-managers), gender, and marital status. Hotel managers reported significantly more stressors than hourly employees. There were no significant differences by gender or marital status. The third aim was to investigate whether the various stressors were linked to hotel employee health and work outcomes. More employee and coworker stressors were linked to more negative physical health symptoms. Also, interpersonal tensions at work were linked to lower job satisfaction and greater turnover intentions. PMID:23794780

  2. Impact of the Great East Japan Earthquake on Hotel Industry in Pacific Tohoku Prefectures ---From Spatio-Temporal Dependence of Hotel Availability---

    NASA Astrophysics Data System (ADS)

    Sato, A.

    This paper investigates the impact of the Great Japan Earthquake(and subsequent tsunami turmoil) on socio-economic activities by using data on hotel opportunities collected from an electronic hotel booking service. A method to estimate both primary and secondary regional effects of a natural disaster on human behavior is proposed. It is confirmed that temporal variation in the regional share of available hotels before and after a natural disaster may be an indicator to measure the socio-economic impact at each district.

  3. 24 CFR 203.16 - Certificate and contract regarding use of dwelling for transient or hotel purposes.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... use of dwelling for transient or hotel purposes. 203.16 Section 203.16 Housing and Urban Development... use of dwelling for transient or hotel purposes. Every application filed with respect to insurance of... housing or any part thereof covered by the mortgage for transient or hotel purposes, together with...

  4. 24 CFR 203.16 - Certificate and contract regarding use of dwelling for transient or hotel purposes.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... use of dwelling for transient or hotel purposes. 203.16 Section 203.16 Housing and Urban Development... use of dwelling for transient or hotel purposes. Every application filed with respect to insurance of... housing or any part thereof covered by the mortgage for transient or hotel purposes, together with...

  5. 24 CFR 203.16 - Certificate and contract regarding use of dwelling for transient or hotel purposes.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... use of dwelling for transient or hotel purposes. 203.16 Section 203.16 Housing and Urban Development... use of dwelling for transient or hotel purposes. Every application filed with respect to insurance of... housing or any part thereof covered by the mortgage for transient or hotel purposes, together with...

  6. 24 CFR 203.16 - Certificate and contract regarding use of dwelling for transient or hotel purposes.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... use of dwelling for transient or hotel purposes. 203.16 Section 203.16 Housing and Urban Development... use of dwelling for transient or hotel purposes. Every application filed with respect to insurance of... housing or any part thereof covered by the mortgage for transient or hotel purposes, together with...

  7. 24 CFR 203.16 - Certificate and contract regarding use of dwelling for transient or hotel purposes.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... use of dwelling for transient or hotel purposes. 203.16 Section 203.16 Housing and Urban Development... use of dwelling for transient or hotel purposes. Every application filed with respect to insurance of... housing or any part thereof covered by the mortgage for transient or hotel purposes, together with...

  8. REEP/Hotel Workplace Literacy Project. Evaluation Report. 1988-1990 Grant Period.

    ERIC Educational Resources Information Center

    Peterson, Morris

    The Arlington Education and Employment Program (REEP)/Hotel Workplace Literacy Project served 230 functionally illiterate adults working in hotels and a real estate maintenance firm in Virginia. Job-related English and math, citizenship preparation, and work awareness instruction was provided. An evaluation found that: (1) the project effectively…

  9. Does Embedding Social Media Channels in Hotel Websites Influence Travelers' Satisfaction and Purchase Intentions?

    ERIC Educational Resources Information Center

    Aluri, Ajay Kumar

    2012-01-01

    In the Internet world today, social media channels have emerged as a top share of Internet usage, and more travelers have started using them to make their hotel plans and purchases. Because of the recommendations of researchers and practitioners, hotel organizations have already embraced social media and have embedded their links on their host…

  10. The Marketing Effectiveness of Hotel Facebook Pages: From Perspectives of Customers and Messages

    ERIC Educational Resources Information Center

    Leung, Xi Yu

    2012-01-01

    In the hotel industry, social media marketing has become a new trend hoteliers are chasing and an increasing number of hotels are using social media to promote their business. However, the marketing effectiveness of social media is still a big challenge in both academic and business world. Since social media marketing is totally different from…

  11. Human Resource Development in the Irish Hotel Industry: The Case of the Small Firm.

    ERIC Educational Resources Information Center

    Nolan, Clara

    2002-01-01

    A profile of small businesses in the Irish hotel industry shows that all claim to believe in human resource development but few practice it. Small hotels favor informal, specific job training focused on solution of immediate problems rather than long-term development. (Contains 119 references.) (SK)

  12. 77 FR 37326 - Safety Zone; Grand Hotel 125th Anniversary Fireworks Celebration, Mackinaw Island, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-21

    .... SUPPLEMENTARY INFORMATION: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Grand Hotel 125th Anniversary Fireworks... launched from a point on Lake Huron to commemorate the Grand Hotel's 125th anniversary. The Captain of...

  13. What Makes Hotel Expatriates Remain in Their Overseas Assignments: A Grounded Theory Study

    ERIC Educational Resources Information Center

    Ho, Zoe Ju-Yu

    2012-01-01

    In this study the researcher uses a qualitative research design to discover what makes hotel expatriates remain in their overseas assignments. In-depth interviews, participant observations, and personal documents are used as data collection methods. Four hotel expatriates are recruited as participants of the study. The collected interview…

  14. Parameters for an Effective Entrepreneurial, Regional, Hotel/Restaurant Management Training Program in Manitoba, Canada.

    ERIC Educational Resources Information Center

    Rossing, Rainer C.

    Owners or managers of 34 small and medium-sized hotels and restaurants in the Assiniboine Community College area were interviewed to acquire information for an entrepreneurial, regional hotel and restaurant (H/R) management training program in Manitoba. A literature review revealed the following: employability, vocational technical, and business…

  15. Hospitality Service: Hotel and Restaurant Management and Culinary Arts Curriculum Guide.

    ERIC Educational Resources Information Center

    Joliet Junior Coll., IL.

    This publication contains competency-based materials for hotel/restaurant management and culinary arts. The materials are designed for students to learn from a work station concept by rotating through a variety of real work settings in a hotel/restaurant environment. In addition, the materials indicate whether or not the students have developed…

  16. Hotel and Restaurant Management; A Bibliography of Books and Audio-Visual Materials.

    ERIC Educational Resources Information Center

    Malkames, James P.; And Others

    This bibliography represents a collection of 1,300 book volumes and audiovisual materials collected by the Luzerne County Community College Library in support of the college's Hotel and Restaurant Management curriculum. It covers such diverse topics as advertising, business practices, decoration, nutrition, hotel law, insurance landscaping, health…

  17. A Trip to the Statler Hilton Hotel. The Special Education Curriculum Series.

    ERIC Educational Resources Information Center

    Kendall, Muriel

    A program designed for high school level work-study classes for students of limited mental ability presents specific curriculum methods and materials to teach information regarding positions available in the hotel industry. A field trip tour of the Boston Statler Hilton Hotel if the focal activity of the unit, and is accompanied by a history of…

  18. Feasibility Study for Hotel/Motel Career Program for Harper College. Volume XIX, No. 1.

    ERIC Educational Resources Information Center

    Lucas, John A.; And Others

    In spring 1990, a study was conducted at William Rainey Harper College (WRHC) to determine the feasibility of adding a career program in Hotel/Motel Management (HMM) to the current Food Service Program. Surveys were sent to 53 hotels and motels in the WRHC service area to determine employment demands that would affect the hiring of graduates of…

  19. 12. VIEW OF MERCHANTS' HOTEL IN MID 19th CENTURY, 'FOURTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. VIEW OF MERCHANTS' HOTEL IN MID- 19th CENTURY, 'FOURTH STREET, PHILA., WEST SIDE, FROM MARKET TO ARCH', as it appeared in The Baxter Panoramic Business Directory, Est. 1857 which is available for viewing at the Free Library of Philadelphia, in the Castner Collection, Philadelphia Vol. No. 12, 'Streets 1'. - Merchants' Hotel, 40-50 North Fourth Street, Philadelphia, Philadelphia County, PA

  20. The impact of virtual reality functions of a hotel website on travel anxiety.

    PubMed

    Lee, Ook; Oh, Ji-Eun

    2007-08-01

    This study deals with the impact of virtual reality (VR) features that are embedded in a hotel website on travelers' anxiety. Having more information is thought to be a factor in relieving anxiety in travel. A hotel website can be a good place for gathering information about the accommodation. In this study, we posit that a hotel website with VR functions should lead to a reduction in travelers' anxiety about travel. We built a website of a hotel and used VR functions to show the exterior, the lobby, a guest room, and a restaurant through an interactive and spatial shot of the hotel images. The experiment was conducted with a premise that the subjects were about to embark on a journey to an unknown place and to stay at an unknown hotel whose website contained VR functions. The subjects were asked to play with VR functions of the hotel website and then to complete a survey with questions regarding the degree of anxiety on the travel and psychological relief that might have been perceived by the subjects. The result confirms our hypothesis that there is a statistically significant relationship between the degree of travel anxiety and psychological relief caused by the use of VR functions of a hotel website.

  1. Prevalence of Legionella spp. in water systems of hospitals and hotels in South Western Greece.

    PubMed

    Fragou, K; Kokkinos, P; Gogos, C; Alamanos, Y; Vantarakis, A

    2012-01-01

    The aim of the present study was to determine the prevalence of Legionella spp. in water systems of hospitals and hotels located in South Western Greece, to study the molecular epidemiology of the isolated strains and their possible association with bacterial contamination (total count and Pseudomonas aeruginosa), the water pH, and temperature. A prevalence survey for Legionella spp. by culturing techniques in water distribution systems of eight hospitals and nine hotels occurred in South Western Greece. Water sampling and microbiological analysis were carried out following the ISO methods. Legionella pneumophila was detected in 33% and 36% of the distribution systems of hospitals and hotels, respectively. Our survey results suggest a frequent prevalence of elevated concentrations of Legionella spp. in water systems of hospitals and hotels. Our investigation has confirmed the need to regularly monitor the microbiological condition of water systems in hospitals and hotels.

  2. Indoor radon levels in selected hot spring hotels in Guangdong, China.

    PubMed

    Song, Gang; Zhang, Boyou; Wang, Xinming; Gong, Jingping; Chan, Daniel; Bernett, John; Lee, S C

    2005-03-01

    Guangdong is one of the provinces that have most hot springs in China, and many hotels have been set up near hot springs, with spring water introduced into the bath inside each hotel room for hot spring bathing to attract tourists. In the present study, we measured radon in indoor and outdoor air, as well as in hot spring waters, in four hot spring hotels in Guangdong by using NR-667A (III) continuous radon detector. Radon concentrations ranged 53.4-292.5 Bq L(-1) in the hot spring water and 17.2-190.9 Bq m(-3) in outdoor air. Soil gas intrusion, indoor hot spring water use and inefficient ventilation all contributed to the elevated indoor radon levels in the hotel rooms. From the variation of radon levels in closed unoccupied hotel rooms, soil gas intrusion was found to be a very important source of indoor radon in hotel rooms with floors in contact with soils. When there was spring water bathing in the bathes, average radon levels were 10.9-813% higher in the hotel rooms and 13.8-489% higher in bathes compared to their corresponding average levels when there was no spring water use. Spring water use in the hotel rooms had radon transfer coefficients from 1.6x10(-4) to 5.0x10(-3). Radon in some hotel rooms maintained in concentrations much higher than guideline levels might thus have potential health risks to the hotel workers, and technical and management measures should be taken to lower their exposure of radon through inhalation.

  3. Hotel Cedes 7 months' savings for total lighting retrofit

    SciTech Connect

    Warrock, A.M.

    1983-07-11

    In an unusual shared-savings agreement, the Hilton Florida Center at Orlando, where a retrofit program was begun two years ago, will give up all savings from a lighting retrofit program for seven months, avoiding upfront costs of equipment purchase, and will then become sole owner of the equipment and beneficiary of the savings. The four-month-old program has improved the lighting and cut electricity costs $2000 to $2500 per month, which would have been a six-month payback. Contracts for two other hotels are expected where retrofitting has begun. Retrofit details are given.

  4. Solar cooling system performance, Frenchman's Reef Hotel, Virgin Islands

    NASA Astrophysics Data System (ADS)

    Harber, H.

    1981-09-01

    The operational and thermal performance of a variety of solar systems are described. The Solar Cooling System was installed in a hotel at St. Thomas, U. S. Virgin Islands. The system consists of the evacuated glass tube collectors, two 2500 gallon tanks, pumps, computerized controller, a large solar optimized industrial sized lithium bromide absorption chiller, and associated plumbing. Solar heated water is pumped through the system to the designed public areas such as lobby, lounges, restaurant and hallways. Auxiliary heat is provided by steam and a heat exchanger to supplement the solar heat.

  5. Solar cooling system performance, Frenchman's Reef Hotel, Virgin Islands

    NASA Technical Reports Server (NTRS)

    Harber, H.

    1981-01-01

    The operational and thermal performance of a variety of solar systems are described. The Solar Cooling System was installed in a hotel at St. Thomas, U. S. Virgin Islands. The system consists of the evacuated glass tube collectors, two 2500 gallon tanks, pumps, computerized controller, a large solar optimized industrial sized lithium bromide absorption chiller, and associated plumbing. Solar heated water is pumped through the system to the designed public areas such as lobby, lounges, restaurant and hallways. Auxiliary heat is provided by steam and a heat exchanger to supplement the solar heat.

  6. What do hotels and hospitals have in common? How we can learn from the hotel industry to take better care of patients.

    PubMed

    Zygourakis, Corinna C; Rolston, John D; Treadway, James; Chang, Susan; Kliot, Michel

    2014-01-01

    Despite widely divergent public perceptions and goals, hotels and hospitals share many core characteristics. Both serve demanding and increasingly well-informed clienteles, both employ a large hierarchy of workers with varying levels of responsibility, and both have payments that are increasingly tied to customer/patient evaluations. In the hotel industry, decades of management experience and market research have led to widespread improvements and innovations that improve customer satisfaction. But there has been incredibly little cross-fertilization between the hotel and hospital industries. In this paper, we first consider the changes in the healthcare system that are forcing hospitals to become more concerned with patient satisfaction. We discuss the similarities and differences between the hotel and hospital industries, and then outline several of the unique challenges that neurosurgeons face in taking care of patients and increasing their comfort. We cite specific lessons from the hotel industry that can be applied to patients' preadmission, check-in, hospital stay, discharge planning, and poststay experiences. We believe that hospitals can and should leverage the successful advances within the hotel industry to improve patient satisfaction, without having to repeat identical research or market experimentation. We hope this will lead to rapid improvements in patient experiences and overall wellbeing. PMID:24818061

  7. What do hotels and hospitals have in common? How we can learn from the hotel industry to take better care of patients.

    PubMed

    Zygourakis, Corinna C; Rolston, John D; Treadway, James; Chang, Susan; Kliot, Michel

    2014-01-01

    Despite widely divergent public perceptions and goals, hotels and hospitals share many core characteristics. Both serve demanding and increasingly well-informed clienteles, both employ a large hierarchy of workers with varying levels of responsibility, and both have payments that are increasingly tied to customer/patient evaluations. In the hotel industry, decades of management experience and market research have led to widespread improvements and innovations that improve customer satisfaction. But there has been incredibly little cross-fertilization between the hotel and hospital industries. In this paper, we first consider the changes in the healthcare system that are forcing hospitals to become more concerned with patient satisfaction. We discuss the similarities and differences between the hotel and hospital industries, and then outline several of the unique challenges that neurosurgeons face in taking care of patients and increasing their comfort. We cite specific lessons from the hotel industry that can be applied to patients' preadmission, check-in, hospital stay, discharge planning, and poststay experiences. We believe that hospitals can and should leverage the successful advances within the hotel industry to improve patient satisfaction, without having to repeat identical research or market experimentation. We hope this will lead to rapid improvements in patient experiences and overall wellbeing.

  8. What do hotels and hospitals have in common? How we can learn from the hotel industry to take better care of patients

    PubMed Central

    Zygourakis, Corinna C.; Rolston, John D.; Treadway, James; Chang, Susan; Kliot, Michel

    2014-01-01

    Despite widely divergent public perceptions and goals, hotels and hospitals share many core characteristics. Both serve demanding and increasingly well-informed clienteles, both employ a large hierarchy of workers with varying levels of responsibility, and both have payments that are increasingly tied to customer/patient evaluations. In the hotel industry, decades of management experience and market research have led to widespread improvements and innovations that improve customer satisfaction. But there has been incredibly little cross-fertilization between the hotel and hospital industries. In this paper, we first consider the changes in the healthcare system that are forcing hospitals to become more concerned with patient satisfaction. We discuss the similarities and differences between the hotel and hospital industries, and then outline several of the unique challenges that neurosurgeons face in taking care of patients and increasing their comfort. We cite specific lessons from the hotel industry that can be applied to patients’ preadmission, check-in, hospital stay, discharge planning, and poststay experiences. We believe that hospitals can and should leverage the successful advances within the hotel industry to improve patient satisfaction, without having to repeat identical research or market experimentation. We hope this will lead to rapid improvements in patient experiences and overall wellbeing. PMID:24818061

  9. Best practices to reduce the accident rate hotel

    NASA Astrophysics Data System (ADS)

    García Revilla, M. R.; Kahale Carrillo, D. T.

    2014-10-01

    Examining the available databases and existing tourism organizations can conclude that appear studies on accidents and their relationship with other variables. But in our case we want to assess this relationship in the performance of the hotel in relation to lower the accident rate. The Industrial Safety studies analyzing this accident causes (why they happen), their sources (committed activities), their agents (participants work means), its type (how the events occur or develop), all in order to develop prevention. In our case, as accidents happen because people commit wrongful acts or because the equipment, tools, machinery or workplaces are not in proper conditions, the preventive point of view we analyze through the incidence of workplace accidents hotel subsector. The crash occurs because there is a risk, so that adequate control of it would avoid despite individual factors. Absenteeism or absence from work was taken into account first by Dubois in 1977, as he realized the time lost in the nineteenth century due to the long working hours, which included the holidays. Motivation and job satisfaction were the elements that have been most important in the phenomenon of social psychology.

  10. One for the road: on the utility of citation data for identifying problem hotels.

    PubMed

    Wood, L J; McLean, S; Davidson, J; Montgomery, I M

    1995-01-01

    Drink drivers arrested in Tasmania are routinely asked by police where they had last been drinking, and these data were examined for 716 drivers arrested in Southern Tasmania during a 4-month period in 1992. Nearly half (43%) of arrested drink drivers cited individual hotels as the place where they had last been drinking. This enabled a citation score to be assigned to each of the 82 hotels in metropolitan Hobart. The distribution of citation scores was highly skewed, with eight hotels accounting for 45% of hotel citations, and two accounting for 20%. The hotels' citation scores were compared in relation to the rank order of their licence fees, since better measures of patronage proved unobtainable. Some hotels with small total alcohol sales did appear to have an unexpectedly large number of citations, suggesting less than responsible serving practices. Hoteliers' comments were sought on the interpretation of citation scores, and incorporated into a discussion of the limitations of the data in determining the extent of individual hotel responsibility for drink drivers. Important questions remaining include (1) what is the validity of citations made by drink drivers at the time of arrest; (2) what appropriate and quantifiable denominator can be used to adjust the number of citations to the level of patronage; and (3) what level of citations is too high and requires action?

  11. The reproductive experience of women living in hotels for the homeless in New York City.

    PubMed

    Chavkin, W; Kristal, A; Seabron, C; Guigli, P E

    1987-01-01

    Incidence of low birth weight, infant mortality and attendance at prenatal care were estimated for 401 residents of welfare hotels in New York City and compared to data from housing project residents and the city-wide population. Hotel residents and the pertinent data were ascertained from children's birth certificates dating from January 1982 to June 1984. In 1984 there were 2889 families (3498 adults and 6789 children) housed in 48 privately managed hotels and 7 shelters in the city, set up as emergency housing for the homeless. Most of these families were single women; over 50% were under 25. The racial and ethnic composition of hotel residents was similar to that of housing project tenants. The hotel residents have high birth rates: from 7/month in 1982 to 23/month in 1984. They receive significantly less prenatal care than project or city dwellers; more than half have 0-3 visits. The hotel residents had 2.5 times the likelihood of getting no prenatal care than project tenants, and 4.12 times the likelihood than the citywide population. Mean birth weight for hotel infants was 2979 g; for project infants 3128 g; for city infants 3253 g. Both welfare groups were significantly lower than citywide average birth weights. The infant mortality was 24.9 per 1000 for the hotel group, 16.6 for the project group, and 12.0 for the city population. The stress and inconvenience of living far from social service offices, clinics, schools and shops was considered the likely cause of poor attendance at prenatal care. It was recommended that the city provide on-site health education and care, social and nutrition services in the hotels, and refrigerators for mothers with newborn children.

  12. How Clean Are Hotel Rooms? Part I: Visual Observations vs. Microbiological Contamination.

    PubMed

    Almanza, Barbara A; Kirsch, Katie; Kline, Sheryl Fried; Sirsat, Sujata; Stroia, Olivia; Choi, Jin Kyung; Neal, Jay

    2015-01-01

    Current evidence of hotel room cleanliness is based on observation rather than empirically based microbial assessment. The purpose of the study described here was to determine if observation provides an accurate indicator of cleanliness. Results demonstrated that visual assessment did not accurately predict microbial contamination. Although testing standards have not yet been established for hotel rooms and will be evaluated in Part II of the authors' study, potential microbial hazards included the sponge and mop (housekeeping cart), toilet, bathroom floor, bathroom sink, and light switch. Hotel managers should increase cleaning in key areas to reduce guest exposure to harmful bacteria. PMID:26427262

  13. A fuzzy MCDM model with objective and subjective weights for evaluating service quality in hotel industries

    NASA Astrophysics Data System (ADS)

    Zoraghi, Nima; Amiri, Maghsoud; Talebi, Golnaz; Zowghi, Mahdi

    2013-12-01

    This paper presents a fuzzy multi-criteria decision-making (FMCDM) model by integrating both subjective and objective weights for ranking and evaluating the service quality in hotels. The objective method selects weights of criteria through mathematical calculation, while the subjective method uses judgments of decision makers. In this paper, we use a combination of weights obtained by both approaches in evaluating service quality in hotel industries. A real case study that considered ranking five hotels is illustrated. Examples are shown to indicate capabilities of the proposed method.

  14. Factors Influencing e-Business Adoption in the Greek Hotel Sector

    NASA Astrophysics Data System (ADS)

    Samanta, Ir.; Kyriazopoulos, P.

    The purpose of this research is to identify the impact of business process improvement in the area of e-marketing in the hotel industry. The research identifies the barriers which block organizational change effort. A sample of thirty hotels in the city of Athens was used.This paper presents a SWOT analysis of the hotel sector, identifying the strengths, weaknesses, opportunities and threats that firms faced in the process of change. The results show that the majority of firms use, to a small extent, the e-marketing concept to improve their communication strategy and reach market segments.

  15. Early Bird Visions and Telchnology for Space Hotel

    NASA Astrophysics Data System (ADS)

    Amekrane, R.; Holze, C.

    2002-01-01

    The International Space Station was planed for research purposes. In 2001 the first private man, Denis Tito, visited the ISS and the second private man, Mark Shuttleworth is following him. Space pioneers as Wernher von Braun and Sir Arthur C. Clarke had the dream that one day a space station in earth orbit will host tourists. It is evident that the ISS is not designed to host tourists. Therefore the dream is still open. Asking the question "how should a space station should look like to host tourists?" the German Aerospace Society DGLR e.V. initiated in April 2001 a contest under the patronage of . Mr. Joerg Feustel-Buechl, the Director of Manned Spaceflight and Microgravity, European Space Agency (ESA). Because the definition and design of living space is the content of architecture the approach was to gather new ideas from young architects in cooperation with space experts. This contest was directed at students of architecture and the task set was to design a hotel for the earth orbit and to accommodate 220 guests. The contest got the name "Early Bird - Visions of a Space Hotel". The results and models of the student's work were shown in an exhibition in Hamburg/Germany, which was open to the public from September 19th till October 20th 2001. During the summer term 2001 fifty students from the university occupied themselves with the topic, "Design of a hotel for space". During this time seventeen designs were completed. Having specialists, as volunteers, in the field of space in charge meant that it could be ensured that the designs reflected a certain possibility of being able to be realized. Within this interdisciplinary project both parties learned from each other. The 17 different designs were focused on the expectations and needs of a future space tourist. The design are for sure not feasible today, but the designs are in that sense realistic that they could be built in future. This paper will present an overview of the 17 designs as a vision of a future

  16. Shared-savings cuts hotel's losses from EMS removal

    SciTech Connect

    Galvin, C.

    1982-11-08

    A shared-savings contract will minimize the Myrtle Beach, SC Downtown Holiday Inn's losses of replacing a poorly performing Energy Master energy-management system with Scientific Atlanta equipment. The contract with Energy Master Inc. (EMI), which saved Holiday Inn the $80,000 to $90,000 purchase price, also permitted removal (a year after installation) of the equipment when it failed to generate energy savings. A dispute between Associated Energy Consultants (AEC), which was to receive half the savings in exchange for arranging the equipment financing, is described. At $51,745, the 262-point Scientific Atlanta system should have a 1.7-year payback. The hotel's electric bills were $2000 a month lower during the first three months of operation. (DCK)

  17. Hotel Payload - a low-cost sounding rocket concept - for middle atmosphere and ionosphere

    NASA Astrophysics Data System (ADS)

    Hauglund, Kenneth; Hansen, Gudmund

    2005-08-01

    European scientists are invited to utilize the "Hotel Payload" concept developed at Andøya Rocket Range (ARR) for scientific research in Middle Atmosphere and Ionosphere. The concept is shaped to give scientists predictability and assurance on configuration, costs and timeframe for their projects. The scientists are offered one sounding rocket partner from planning till launch - so they can focus on their instruments. To demonstrate the capabilities, this paper presents the "Hotel Payload" concept, its configurations and specific projects with instrumentation.

  18. Search and selection hotel system in Surabaya based on geographic information system (GIS) with fuzzy logic

    NASA Astrophysics Data System (ADS)

    Purbandini, Taufik

    2016-03-01

    Surabaya is a metropolitan city in Indonesia. When the visitor has an interest in Surabaya for several days, then the visitor was looking for lodging that is closest to the interests of making it more efficient and practical. It was not a waste of time for the businessman because of congestion and so we need full information about the hotel as an inn during a stay in Surabaya began name, address of the hotel, the hotel's website, the distance from the hotel to the destination until the display of the map along the route with the help of Google Maps. This system was designed using fuzzy logic which aims to assist the user in making decisions. Design of hotel search and selection system was done through four stages. The first phase was the collection of data and as the factors that influence the decision-making along with the limit values of these factors. Factors that influence covers a distance of the hotel, the price of hotel rooms, and hotel reviews. The second stage was the processing of data and information by creating membership functions. The third stage was the analysis of systems with fuzzy logic. The steps were performed in systems analysis, namely fuzzification, inference using Mamdani, and defuzzification. The last stage was the design and construction of the system. Designing the system using use case diagrams and activity diagram to describe any process that occurs. Development system includes system implementation and evaluation systems. Implementation of mobile with Android-based system so that these applications were user friendly.

  19. A framework for stochastic simulation of distribution practices for hotel reservations

    SciTech Connect

    Halkos, George E.; Tsilika, Kyriaki D.

    2015-03-10

    The focus of this study is primarily on the Greek hotel industry. The objective is to design and develop a framework for stochastic simulation of reservation requests, reservation arrivals, cancellations and hotel occupancy with a planning horizon of a tourist season. In Greek hospitality industry there have been two competing policies for reservation planning process up to 2003: reservations coming directly from customers and a reservations management relying on tour operator(s). Recently the Internet along with other emerging technologies has offered the potential to disrupt enduring distribution arrangements. The focus of the study is on the choice of distribution intermediaries. We present an empirical model for the hotel reservation planning process that makes use of a symbolic simulation, Monte Carlo method, as, requests for reservations, cancellations, and arrival rates are all sources of uncertainty. We consider as a case study the problem of determining the optimal booking strategy for a medium size hotel in Skiathos Island, Greece. Probability distributions and parameters estimation result from the historical data available and by following suggestions made in the relevant literature. The results of this study may assist hotel managers define distribution strategies for hotel rooms and evaluate the performance of the reservations management system.

  20. "There's no-fresh air there": narratives of smoke exposure among residents of extended-stay hotels.

    PubMed

    Lewinson, Terri; Bryant, Lawrence Oliver

    2015-05-01

    Hotel environments have been identified as places where hospitality workers and patrons are at an increased risk for smoke exposure and associated health hazards. However, little research has been conducted to understand experiences of long-term hotel residents. This article presents narrative accounts of tobacco smoke exposure from 37 residents at extended-stay hotels in a large metropolitan Atlanta county. Residents' narratives included an awareness of smoking as an unhealthy habit but a shared activity that facilitates social engagement at the hotel. Secondhand smoke narratives included descriptions of exposure from roommates and hotel neighbors. Thirdhand smoke narratives included reports of persistent pollution and smoke residue in the hotel environment. These results suggest a need for further research to understand the extent and impact of tobacco smoke exposure among this understudied population. The implications of this research support the efforts of social workers to engage in clean air advocacy and policy making for a vulnerable population. PMID:26027415

  1. "There's no-fresh air there": narratives of smoke exposure among residents of extended-stay hotels.

    PubMed

    Lewinson, Terri; Bryant, Lawrence Oliver

    2015-05-01

    Hotel environments have been identified as places where hospitality workers and patrons are at an increased risk for smoke exposure and associated health hazards. However, little research has been conducted to understand experiences of long-term hotel residents. This article presents narrative accounts of tobacco smoke exposure from 37 residents at extended-stay hotels in a large metropolitan Atlanta county. Residents' narratives included an awareness of smoking as an unhealthy habit but a shared activity that facilitates social engagement at the hotel. Secondhand smoke narratives included descriptions of exposure from roommates and hotel neighbors. Thirdhand smoke narratives included reports of persistent pollution and smoke residue in the hotel environment. These results suggest a need for further research to understand the extent and impact of tobacco smoke exposure among this understudied population. The implications of this research support the efforts of social workers to engage in clean air advocacy and policy making for a vulnerable population.

  2. Preliminary report: outbreak of Legionnaires disease in a hotel in Calp, Spain, update on 22 February 2012.

    PubMed

    Vanaclocha, H; Guiral, S; Morera, V; Calatayud, M A; Castellanos, M; Moya, V; Jerez, G; Gonzalez, F

    2012-02-23

    Research is ongoing on eighteen cases of Legionellosis, including four deaths, identified among tourists and employees in a hotel in Calp, Spain. Cases occurred during a period of two months, indicating the possibility of a point-source transmission at the hotel. An environmental investigation identified several positive samples in the hotel, which as a precautionary measure, was closed until requested improvements were made. Surveillance measures currently remain active.

  3. Foodborne gastroenteritis due to Norwalk virus in a Winnipeg hotel.

    PubMed Central

    Sekla, L; Stackiw, W; Dzogan, S; Sargeant, D

    1989-01-01

    Within 1 week four separate incidents of gastroenteritis presumed to be foodborne were reported by guests of a Winnipeg hotel. Investigation revealed poor food-handling practices and illness among the kitchen staff. Elevated bacterial counts and Escherichia coli were found in 15 of 24 samples of food tested, and Staphylococcus aureus was isolated from 2 pastry samples. Culture of 14 stool samples for bacteria yielded Clostridium perfringens in 1 sample from a staff member and coagulase-positive S. aureus in 2 samples from staff members and 3 from guests. All of the S. aureus isolates were nonenterotoxigenic and had three different phage patterns. Electron microscopy and immunoelectron microscopy revealed the prototype Norwalk virus in five (56%) of nine stool samples; four samples were from guests, and one was from a kitchen employee. The employee had had diarrhea 24 hours before the first outbreak and was thus believed to be the source of the virus infection, possibly through food handling. This is the first report of Norwalk virus isolation and the first of foodborne Norwalk virus transmission in Canada. A review of foodborne Norwalk virus infections is presented. Images Fig. 1 Fig. 2 PMID:2541881

  4. The isolation of low frequency impact sounds in hotel construction

    NASA Astrophysics Data System (ADS)

    LoVerde, John J.; Dong, David W.

    2002-11-01

    One of the design challenges in the acoustical design of hotels is reducing low frequency sounds from footfalls occurring on both carpeted and hard-surfaced floors. Research on low frequency impact noise [W. Blazier and R. DuPree, J. Acoust. Soc. Am. 96, 1521-1532 (1994)] resulted in a conclusion that in wood construction low frequency impact sounds were clearly audible and that feasible control methods were not available. The results of numerous FIIC (Field Impact Insulation Class) measurements performed in accordance with ASTM E1007 indicate the lack of correlation between FIIC ratings and the reaction of occupants in the room below. The measurements presented include FIIC ratings and sound pressure level measurements below the ASTM E1007 low frequency limit of 100 Hertz, and reveal that excessive sound levels in the frequency range of 63 to 100 Hertz correlate with occupant complaints. Based upon this history, a tentative criterion for maximum impact sound level in the low frequency range is presented. The results presented of modifying existing constructions to reduce the transmission of impact sounds at low frequencies indicate that there may be practical solutions to this longstanding problem.

  5. Economic analysis of the water demand in the hotels and restaurants sector: Shadow prices and elasticities

    NASA Astrophysics Data System (ADS)

    Angulo, Ana; Atwi, Majed; Barberán, Ramón; Mur, Jesús

    2014-08-01

    Despite the growing economic importance of tourism, and its impact on relative water shortage, little is known about the role that water plays in the productive process of hotels and restaurants and, therefore, the possible implications of water demand management policy for this sector. This study aims to fill this gap. It is based on the microdata of 676 firms in the sector, operating in the city of Zaragoza (Spain) for a 12 year period. Based on the Translog cost function, we estimate the shadow price of water in the short run and, from a long-run perspective, its direct price elasticity, its cross elasticities relative to labor, capital, and supplies, and its elasticity with respect to the level of output. The results obtained show that water provides sector firms returns that are on average higher than its price, although in the case of hotels the margin is really narrow. This situation provides policy makers with a margin for applying price increases without affecting the sector's viability, with some caution in the case of hotels. Water demand elasticity equals -0.38 in the case of hotels, but it is not significant in the case of restaurants and bar-cafes; hence, only in hotels is there potential for influencing water use patterns, encouraging the resource's conservation through pricing policy. Moreover, capital is a substitutive factor of water, and the elasticity of water with respect to output is 0.40, all of which should also be considered by policy makers in water resource management.

  6. Energy End-Use Patterns in Full-Service Hotels: A Case Study

    SciTech Connect

    Placet, Marylynn; Katipamula, Srinivas; Liu, Bing; Dirks, James A.; Xie, YuLong; Sullivan, Greg; Walent, Jim; Williamson, Rebecca

    2010-06-30

    The U.S. Department of Energy (DOE) recently initiated a program -- Commercial Building Partnerships (CBP) -- to work with private-sector companies in the design of highly-efficient retrofit and new construction projects. Pacific Northwest National Laboratory (PNNL) is conducting a project with a major hotel company to retrofit a full-service, large hotel with the goal of reducing energy consumption by at least 30%. The first step of the project was an intensive metering and monitoring effort aimed at understanding energy end use patterns in the hotel. About 10% of the guest rooms (32), as well as circuits for most of the end uses in public spaces (lighting, elevators, air handlers and other HVAC system components, and various equipment), were equipped with meters. Data are being collected at 1- or 5-minute intervals and downloaded on a monthly basis for analysis. This paper presents results from the first four months of the monitoring effort, which revealed energy end-use consumption patterns, variability of guest room energy use, daily load curves, monthly variations, and other aspects of hotel energy use. Metered end-use data for hotels at this level of detail are not available from any currently-available public sources. This study presents unique information and insight into energy end-use patterns in the lodging sector of commercial buildings and can also serve as a case study of a complex sub-metering project.

  7. Suicide by jumping from high-rise hotels. Fulton County, Georgia, 1967-1986.

    PubMed

    Hanzlick, R; Masterson, K; Walker, B

    1990-12-01

    During a 20-year period from 1967 through 1986, 19 suicidal jumps from high-rise hotels (HRHs) accounted for 24% of all fatal jumping episodes and 1% of all suicides in Fulton County, Georgia, U.S.A. The rate of suicidal jumps from HRHs did not increase during the study period. The number of fatal jumps per hotel-year correlated with the height of the interior hotel atrium. The mean age for all victims was 34 years, and 63% of victims were white males. The majority of victims were local residents who were alone when they jumped and were not registered hotel guests. Registered guests tended to jump from the floor on which their room was located whereas nonregistered individuals tended to jump from the upper-most floors in the hotel. Of 19 HRH jumps, 13 occurred from the inside. Suicide notes were found in 37% of cases. HRH jumps were least common between 6 p.m. and midnight, all decedents were dressed in street clothing, only one was heard to have screamed, and all but one were dead on the scene. Alcohol and drug involvement was minimal. We hope that this information will be useful to those who investigate such deaths and to those who study the behavioral manifestations of suicide.

  8. Spatio-temporal Hotelling observer for signal detection from image sequences

    PubMed Central

    Caucci, Luca; Barrett, Harrison H.; Rodríguez, Jeffrey J.

    2010-01-01

    Detection of signals in noisy images is necessary in many applications, including astronomy and medical imaging. The optimal linear observer for performing a detection task, called the Hotelling observer in the medical literature, can be regarded as a generalization of the familiar prewhitening matched filter. Performance on the detection task is limited by randomness in the image data, which stems from randomness in the object, randomness in the imaging system, and randomness in the detector outputs due to photon and readout noise, and the Hotelling observer accounts for all of these effects in an optimal way. If multiple temporal frames of images are acquired, the resulting data set is a spatio-temporal random process, and the Hotelling observer becomes a spatio-temporal linear operator. This paper discusses the theory of the spatio-temporal Hotelling observer and estimation of the required spatio-temporal covariance matrices. It also presents a parallel implementation of the observer on a cluster of Sony PLAYSTATION 3 gaming consoles. As an example, we consider the use of the spatio-temporal Hotelling observer for exoplanet detection. PMID:19550494

  9. Meeting Competence Needs in the Hotel and Catering Industry Now and in the Future. Research Report 1992.

    ERIC Educational Resources Information Center

    Walker, Anne, Ed.; Hayter, Roy, Ed.

    The hotel and catering industry in the United Kingdom is estimated to have employed 2,392,000 people in 1990--about 9 percent of the total work force in employment in the country. These figures came from a major study into the skills needs of the hotel and catering industry in relation to the current provision of vocational education. Data are…

  10. Lack of hygiene routines among patients and family members at patient hotels--a possible route for transmitting puerperal fever.

    PubMed

    Starlander, Gustaf; Lytsy, Birgitta; Melhus, Asa

    2010-07-01

    The use of patient hotels for ambulatory care of women with uncomplicated deliveries has become a routine in Sweden. This report describes a minor outbreak of a group A Streptococcus strain in 2 newly delivered mothers and their newborn babies at a patient hotel.

  11. A room with a viewpoint revisited: descriptive norms and hotel guests' towel reuse behavior.

    PubMed

    Bohner, Gerd; Schlüter, Lena E

    2014-01-01

    Field experiments on descriptive norms as a means to increase hotel guests' towel reuse [1] were replicated and extended. In two hotels in Germany (Study 1: N = 724; Study 2: N = 204), descriptive norm messages suggesting that 75% of guests had reused their towels, or a standard message appealing to environmental concerns, were placed in guests' bathrooms. Descriptive norm messages varied in terms of proximity of the reference group ("hotel guests" vs. "guests in this room") and temporal proximity (currently vs. two years previous). Reuse of towels was unobtrusively recorded. Results showed that reuse rates were high overall and that both standard and descriptive norm messages increased reuse rates compared to a no-message baseline. However, descriptive norm messages were not more effective than the standard message, and effects of proximity were inconsistent across studies. Discussion addresses cultural and conceptual issues in comparing the present findings with previous ones. PMID:25084348

  12. Work Conditions and Health and Well-Being of Latina Hotel Housekeepers.

    PubMed

    Hsieh, Yu-Chin; Apostolopoulos, Yorghos; Sönmez, Sevil

    2016-06-01

    Hotel housekeepers are exposed to a plethora of disproportionately high work-induced hazards that can lead to adverse health consequences. Latina hotel housekeepers are rendered particularly vulnerable to elevated occupational hazards and resultant health strains due to their socioeconomic status, immigration status, language barriers, and lack of access to healthcare services. The findings from the 27 interviews with Latina hotel housekeepers indicated that the interviewees were exposed to physical, chemical, and social hazards in the workplace and suffered musculoskeletal injuries. In terms of psychological wellness, the time pressure of cleaning rooms quickly and work-related stress stemming from workplace mistreatment emerged as major work-related stressors. Recommendations are made for the introduction of multilevel interventions designed to prevent work-related injuries and illnesses and to promote healthier workplaces.

  13. Economic Evaluation of a Worksite Obesity Prevention and Intervention Trial among Hotel Workers in Hawaii

    PubMed Central

    Meenan, Richard T.; Vogt, Thomas M.; Williams, Andrew E.; Stevens, Victor J.; Albright, Cheryl L.; Nigg, Claudio

    2010-01-01

    Objective Economic evaluation of Work, Weight, and Wellness (3W), a two-year randomized trial of a weight loss program delivered through Hawaii hotel worksites. Methods Business case analysis from hotel perspective. Program resources were micro-costed (2008 dollars). Program benefits were reduced medical costs, fewer absences, and higher productivity. Primary outcome was discounted 24-month net present value (NPV). Results Control program cost $222K to implement over 24 months ($61 per participant), intervention program cost $1.12M ($334). Including overweight participants (body mass index > 25), discounted control NPV was −$217K; −$1.1M for intervention program. Presenteeism improvement of 50% combined with baseline 10% productivity shortfall required to generate positive 24-month intervention NPV. Conclusions 3W’s positive clinical outcomes did not translate into immediate economic benefit for participating hotels, although modest cost savings were observed in the trial’s second year. PMID:20061889

  14. Work Conditions and Health and Well-Being of Latina Hotel Housekeepers.

    PubMed

    Hsieh, Yu-Chin; Apostolopoulos, Yorghos; Sönmez, Sevil

    2016-06-01

    Hotel housekeepers are exposed to a plethora of disproportionately high work-induced hazards that can lead to adverse health consequences. Latina hotel housekeepers are rendered particularly vulnerable to elevated occupational hazards and resultant health strains due to their socioeconomic status, immigration status, language barriers, and lack of access to healthcare services. The findings from the 27 interviews with Latina hotel housekeepers indicated that the interviewees were exposed to physical, chemical, and social hazards in the workplace and suffered musculoskeletal injuries. In terms of psychological wellness, the time pressure of cleaning rooms quickly and work-related stress stemming from workplace mistreatment emerged as major work-related stressors. Recommendations are made for the introduction of multilevel interventions designed to prevent work-related injuries and illnesses and to promote healthier workplaces. PMID:26001842

  15. Optimum contracted-for water supply for hotels in arid coastal regions.

    PubMed

    Lamei, A; von Münch, E; van der Zaag, P; Imam, E

    2009-01-01

    Hotels in arid coastal areas use mainly desalinated water for their domestic water demands, and treated wastewater for irrigating green areas. Private water companies supply these hotels with their domestic water needs. There is normally a contractual agreement stating a minimum requirement that has to be supplied by the water company and that the hotel management has to pay for regardless of its actual consumption ("contracted-for water supply"). This paper describes a model to determine what value a hotel should choose for its contracted-for water supply in order to minimize its total annual water costs. An example from an arid coastal tourism-dominated city is presented: Sharm El Sheikh, Egypt.The managers of hotels with expected high occupancy rates (74% and above) can contract for more than 80%. On the other hand, hotels with expected lower occupancy rates (60% and less) can contract for less than 70% of the peak daily domestic water demand. With a green area ratio of 40 m(2)/room or less, an on-site wastewater treatment plant can satisfy the required irrigation demand for an occupancy rate as low as 42%. Increasing the ratio of green irrigated area to 100 m(2)/room does not affect the contracted-for water supply at occupancy rates above 72%; at lower occupancy rates, however, on-site treated wastewater is insufficient for irrigating the green areas. Increasing the green irrigated area to 120 m(2)/room increases the need for additional water, either from externally sourced treated wastewater or potable water. The cost of the former is much lower than the latter (0.58 versus 1.52 to 2.14 US$/m(3) in the case study area).

  16. Optimum contracted-for water supply for hotels in arid coastal regions.

    PubMed

    Lamei, A; von Münch, E; van der Zaag, P; Imam, E

    2009-01-01

    Hotels in arid coastal areas use mainly desalinated water for their domestic water demands, and treated wastewater for irrigating green areas. Private water companies supply these hotels with their domestic water needs. There is normally a contractual agreement stating a minimum requirement that has to be supplied by the water company and that the hotel management has to pay for regardless of its actual consumption ("contracted-for water supply"). This paper describes a model to determine what value a hotel should choose for its contracted-for water supply in order to minimize its total annual water costs. An example from an arid coastal tourism-dominated city is presented: Sharm El Sheikh, Egypt.The managers of hotels with expected high occupancy rates (74% and above) can contract for more than 80%. On the other hand, hotels with expected lower occupancy rates (60% and less) can contract for less than 70% of the peak daily domestic water demand. With a green area ratio of 40 m(2)/room or less, an on-site wastewater treatment plant can satisfy the required irrigation demand for an occupancy rate as low as 42%. Increasing the ratio of green irrigated area to 100 m(2)/room does not affect the contracted-for water supply at occupancy rates above 72%; at lower occupancy rates, however, on-site treated wastewater is insufficient for irrigating the green areas. Increasing the green irrigated area to 120 m(2)/room increases the need for additional water, either from externally sourced treated wastewater or potable water. The cost of the former is much lower than the latter (0.58 versus 1.52 to 2.14 US$/m(3) in the case study area). PMID:19403967

  17. Theoretical performance analysis of multislice channelized Hotelling observers

    NASA Astrophysics Data System (ADS)

    Goossens, Bart; Platiša, Ljiljana; Philips, Wilfried

    2012-02-01

    Quality assessment of 3D medical images is becoming increasingly important, because of clinical practice rapidly moving in the direction of volumetric imaging. In a recent publication, three multi-slice channelized Hotelling observer (msCHO) models are presented for the task of detecting 3D signals in multi-slice images, where each multi-slice image is inspected in a so called stack-browsing mode. The observer models are based on the assumption that humans observe multi-slice images in a simple two stage process, and each of the models implement this principle in a different way. In this paper, we investigate the theoretical performance, in terms of detection signal-to-noise-ratio (SNR) of msCHO models, for the task of detecting a separable signal in a Gaussian background with separable covariance matrix. We find that, despite the differences in architecture of the three models, they all have the same asymptotical performance in this task (i.e., when the number of training images tends to infinity). On the other hand, when backgrounds with nonseparable covariance matrices are considered, the third model, msCHOc, is expected to perform slightly better than the other msCHO models (msCHOa and msCHOb), but only when sufficient training images are provided. These findings suggest that the choice between the msCHO models mainly depends on the experiment setup (e.g., the number of available training samples), while the relation to human observers depends on the particular choice of the "temporal" channels that the msCHO models use.

  18. A survey of the electrical energy requirement of hotels in Hong Kong

    SciTech Connect

    Chow, W.K.; Chan, K.T. . Dept. of Building Services Engineering)

    1993-01-01

    Electrical energy consumption in commercial buildings accounts for about 50 percent of the total electricity produced in Hong Kong. Investigation of the electrical energy requirement in these buildings is essential to energy conservation. With it, norms of energy use for the buildings in use can be deduced and can be used to establish energy management programs. This article reports on a pioneer investigation on the electrical energy use of hotels in Hong Kong. A survey on the actual consumption in 20 hotels has been conducted, and results are presented. Significance of the norms and the various end-use components of the total electrical energy requirement are discussed.

  19. A towel less: social norms enhance pro-environmental behavior in hotels.

    PubMed

    Reese, Gerhard; Loew, Kristina; Steffgen, Georges

    2014-01-01

    Previous research has shown that normative appeals to engage in environmentally friendly behavior were most effective when they were accompanied by a provincial norm (e.g., when norms matched individuals' immediate situational circumstances). Analyzing hotel guests' towel-use during their stay, the current study tests whether messages employing provincial norms were more effective in reducing towel-use than standard environmental messages. In line with previous findings, guests of two hotels used significantly fewer towels when provincial normative appeals--rather than standard environmental messages--were communicated. These findings corroborate to the body of research demonstrating the power of social norms on environmental behavior.

  20. Comparison of patrons of hotels with early opening and standard hours.

    PubMed

    Smith, D I

    1986-02-01

    A comparison was made of 72 men who were patrons in hotels with 6 A.M. or 7 A.M. opening, with a control group of 87 men interviewed in nearby hotels with 10 A.M. opening. The two groups were very similar on biographical characteristics, yet the men in the early-opening group consumed significantly more alcohol, had more drinking sessions, spent longer in drinking, and had significantly higher SMAST scores. The early opening was apparently facilitating problem drinking.

  1. Outbreaks of infectious intestinal disease associated with person to person spread in hotels and restaurants.

    PubMed

    McDonnell, R J; Wall, P G; Adak, G K; Evans, H S; Cowden, J M; Caul, E O

    1995-09-15

    Twenty-eight outbreaks of infectious intestinal disease, reported as being transmitted mainly by the person to person route, were identified in association with retail catering premises, such as hotels, restaurants, and public houses, in England and Wales between 1992 and 1994. Five thousand and forty-eight people were at risk in these outbreaks and 1234 were affected. Most of the outbreaks (over 90%) occurred in hotels. Small round structured viruses were the most commonly detected pathogens. Diarrhoea and vomiting were common symptoms and most of the outbreaks occurred in the summer months. Control measures to contain infectious individuals and improved hygiene measures are necessary to contain such outbreaks.

  2. Hotel water consumption at a seasonal mass tourist destination. The case of the island of Mallorca.

    PubMed

    Deyà Tortella, Bartolomé; Tirado, Dolores

    2011-10-01

    While it is true that tourism is one of the main driving forces behind economic growth in several world regions, it is also true that tourism can have serious negative environmental impacts, especially with regard to water resources. The tourist water demand can generate big problems of sustainability, mainly in those regions where water is scarce, as occurs in most coastal and small island destinations where a large part of world tourism is concentrated. Given the shortage of literature on the subject, further research into the tourist water demand is required, with particular attention to the hotel sector, since hotels are the most popular option for tourists, displaying higher levels of water consumption. The main purpose of this study is to develop a model to analyse hotel water consumption at a mature sun and sand destination with a strong seasonal pattern and scarcity of water; characteristics shared by some of the world's main tourist destinations. Our model includes a set of different hotel variables associated with physical, seasonal and management-related factors and it improves on the capacity to explain water consumption at such destinations. Following a hierarchical regression methodology, the model is empirically tested through a survey distributed to managers of a representative sample of hotels on the island of Mallorca. From the obtained results, interesting recommendations can be made for both hotel managers and policy makers. Among these, it should be highlighted that the strategic move contemplated by many mature destinations towards a higher quality, low-season model could have significant negative effects in terms of the sustainability of water resources. Our results also conclude that managerial decisions, like the system of accommodation that is offered (i.e. the proliferation of the "all-inclusive" formula, both at mature and new destinations), could give rise to the same negative effect. Development of water saving initiatives (usually

  3. Hotel water consumption at a seasonal mass tourist destination. The case of the island of Mallorca.

    PubMed

    Deyà Tortella, Bartolomé; Tirado, Dolores

    2011-10-01

    While it is true that tourism is one of the main driving forces behind economic growth in several world regions, it is also true that tourism can have serious negative environmental impacts, especially with regard to water resources. The tourist water demand can generate big problems of sustainability, mainly in those regions where water is scarce, as occurs in most coastal and small island destinations where a large part of world tourism is concentrated. Given the shortage of literature on the subject, further research into the tourist water demand is required, with particular attention to the hotel sector, since hotels are the most popular option for tourists, displaying higher levels of water consumption. The main purpose of this study is to develop a model to analyse hotel water consumption at a mature sun and sand destination with a strong seasonal pattern and scarcity of water; characteristics shared by some of the world's main tourist destinations. Our model includes a set of different hotel variables associated with physical, seasonal and management-related factors and it improves on the capacity to explain water consumption at such destinations. Following a hierarchical regression methodology, the model is empirically tested through a survey distributed to managers of a representative sample of hotels on the island of Mallorca. From the obtained results, interesting recommendations can be made for both hotel managers and policy makers. Among these, it should be highlighted that the strategic move contemplated by many mature destinations towards a higher quality, low-season model could have significant negative effects in terms of the sustainability of water resources. Our results also conclude that managerial decisions, like the system of accommodation that is offered (i.e. the proliferation of the "all-inclusive" formula, both at mature and new destinations), could give rise to the same negative effect. Development of water saving initiatives (usually

  4. Career Preparation for Hotel-Motel Management and Services. Grade 11, Phase I.

    ERIC Educational Resources Information Center

    Montgomery County Public Schools, Rockville, MD.

    Suggestions arising from a curriculum development workshop led to a curriculum in hotel-motel management and services for high school students which aims to provide them with an opportunity to explore careers in the lodging and hospitality industries. Students will spend half the time in school study of three required subjects and the other half…

  5. Evaluation of Hotel, Restaurant, and Institutional Management Graduates: A Ten Year Review.

    ERIC Educational Resources Information Center

    Johnson, Dona, Comp.; And Others

    A study of graduates from the Hotel, Restaurant, and Institutional Management program at St. Louis Community College at Forest Park was conducted, primarily in order to elicit information from graduates regarding potentially effective recruitment methods for minority groups and women. The study also sought to obtain evaluation of course curriculum…

  6. Workforce Education. Hotel and Motel Workers. A Section 353 Demonstration Project.

    ERIC Educational Resources Information Center

    Polk County Public Schools, Bartow, FL.

    This guide provides an overall view of a program designed to educate adult basic education (ABE) and English-as-a-Second-Language (ESL) students in job-related, language-oriented skills vital to their positions in the hotel/motel industry. The program was designed for the employees of Grenelefe Resort and Conference Center in Haines City, Florida,…

  7. Tourists’ attitudes towards ban on smoking in air-conditioned hotel lobbies in Thailand

    PubMed Central

    Viriyachaiyo, V; Lim, A

    2009-01-01

    Background: Thailand is internationally renowned for its stringent tobacco control measures. In Thailand, a regulation banning smoking in air-conditioned hotel lobbies was issued in late 2006, causing substantial apprehension within the hospitality industry. A survey of tourists’ attitudes toward the ban was conducted. Methods: A cross-sectional survey of 5550 travellers staying in various hotels in Bangkok, Surat Thani, Phuket, Krabi and Songkhla provinces, October 2005 to December 2006. Travellers aged 15 years or older with a check-in duration of at least one day and willing to complete the questionnaire were requested by hotel staff to fill in the 5-minute questionnaire at check-in or later at their convenience. Results: Secondhand cigarette smoke was recognised as harmful to health by 89.7% of respondents. 47.8% of travellers were aware of the Thai regulation banning smoking in air-conditioned restaurants. 80.9% of the respondents agreed with the ban, particularly female non-smokers. 38.6% of survey respondents indicated that they would be more likely to visit Thailand again because of the regulation, 53.4% that the regulation would not affect their decision and 7.9% that they would be less likely to visit Thailand again. Conclusion: Banning smoking in air-conditioned hotel lobbies in Thailand is widely supported by tourists. Enforcement of the regulation is more likely to attract tourists than dissuade them from holidaying in Thailand. PMID:19364754

  8. GUIDE FOR COURSE OF STUDY FOR COOK (HOTEL AND RESTAURANT) (ENTRY).

    ERIC Educational Resources Information Center

    GUNN, VIRLAH

    DESIGNED FOR TEACHER USE, THIS GUIDE FOR TRAINING COOKS IN HOTEL AND RESTAURANT OCCUPATIONS AIMS--(1) TO DEVELOP MANIPULATIVE SKILLS, (2) TO DEVELOP UNDERSTANDING OF THE BASIC PRINCIPLES OF SCIENCE, MATHEMATICS, AND RELATED KNOWLEDGE THAT CONDITION THESE SKILLS, (3) TO UNDERSTAND THE ADVANTAGES OF STEADY EMPLOYMENT, (4) TO DEVELOP HIGH STANDARDS…

  9. 'Bee hotels' as tools for native pollinator conservation: a premature verdict?

    PubMed

    MacIvor, J Scott; Packer, Laurence

    2015-01-01

    Society is increasingly concerned with declining wild bee populations. Although most bees nest in the ground, considerable effort has centered on installing 'bee hotels'--also known as nest boxes or trap nests--which artificially aggregate nest sites of above ground nesting bees. Campaigns to 'save the bees' often promote these devices despite the absence of data indicating they have a positive effect. From a survey of almost 600 bee hotels set up over a period of three years in Toronto, Canada, introduced bees nested at 32.9% of sites and represented 24.6% of more than 27,000 total bees and wasps recorded (47.1% of all bees recorded). Native bees were parasitized more than introduced bees and females of introduced bee species provisioned nests with significantly more female larva each year. Native wasps were significantly more abundant than both native and introduced bees and occupied almost 3/4 of all bee hotels each year; further, introduced wasps were the only group to significantly increase in relative abundance year over year. More research is needed to elucidate the potential pitfalls and benefits of using bee hotels in the conservation and population dynamics of wild native bees. PMID:25785609

  10. Colonization of Legionella species in Turkish baths in hotels in Alanya, Turkey.

    PubMed

    Erdogan, Haluk; Arslan, Hande

    2015-05-01

    This study evaluated the prevalence of Legionella species in water samples collected from Turkish baths in hotels in Alanya, Turkey, from August 2003 to September 2013. Water samples were collected in 100-mL sterile containers and then concentrated by filtration. Heat treatment was used to eliminate other microorganisms from the samples, which were then spread on Legionella-selective-buffered charcoal yeast extract alpha (BCYE-α) agar and on BCYE-α agar supplemented with glycine, vancomycin, polymyxin, and cycloheximide. Cysteine-dependent colonies were identified by latex agglutination. In total, 135 samples from 52 hotels with Turkish baths were evaluated. Legionella species were identified in 11/52 (21.2%) hotels and 18/135 (13.3%) samples. The most frequently isolated species was Legionella pneumophila, with most isolates belonging to serogroups 6 (55.6%) and 1 (22.2%). The colony count was <100 colony-forming units (CFU) mL(-1) in nine samples, from 100 to 1000 CFU mL(-1) in six samples, and >1000 CFU mL(-1) in three samples. These findings suggest that the hot water systems of Turkish baths in hotels must be viewed as a possible source of travel-associated Legionnaires' disease, and preventative measures should be put in place. PMID:25850992

  11. Genomic Investigation of a Legionellosis Outbreak in a Persistently Colonized Hotel

    PubMed Central

    Sánchez-Busó, Leonor; Guiral, Silvia; Crespi, Sebastián; Moya, Víctor; Camaró, María L.; Olmos, María P.; Adrián, Francisco; Morera, Vicente; González-Morán, Francisco; Vanaclocha, Hermelinda; González-Candelas, Fernando

    2016-01-01

    Objectives: A long-lasting legionellosis outbreak was reported between November 2011 and July 2012 in a hotel in Calpe (Spain) affecting 44 patients including six deaths. Intensive epidemiological and microbiological investigations were performed in order to detect the reservoirs. Methods: Clinical and environmental samples were tested for the presence and genetic characterization of Legionella pneumophila. Six of the isolates were subjected to whole-genome sequencing. Results: Sequencing of 14 clinical and 260 environmental samples revealed sequence type (ST) 23 as the main responsible strain for the infections. This ST was found in the spa pool, from where it spread to other hotel public spaces, explaining the ST23 clinical cases, including guests who had not visited the spa. Uncultured clinical specimens showed profiles compatible with ST23, ST578, and mixed patterns. Profiles compatible with ST578 were obtained by direct sequencing from biofilm samples collected from the domestic water system, which provided evidence for the source of infection for non ST23 patients. Whole genome data from five ST23 strains and the identification of different STs and Legionella species showed that different hotel premises were likely colonized since the hotel opening thus explaining how different patients had been infected by distinct STs. Conclusions: Both epidemiological and molecular data are essential in the investigation of legionellosis outbreaks. Whole-genome sequencing data revealed significant intra-ST variability and allowed to make further inference on the short-term evolution of a local colonization of L. pneumophila. PMID:26834713

  12. REEP Hotels/Chambers Federal Workplace Literacy Project. April 1, 1990-December 31, 1991.

    ERIC Educational Resources Information Center

    Arlington County Public Schools, VA. REEP, Arlington Education and Employment Program.

    In an expansion of an earlier National Workplace Literacy Program project, this document reports on a workplace literacy model operated by the Arlington Education and Employment Program (REEP) that includes the Alexandria and Arlington, Virginia Public Schools, the chambers of commerce of both cities, and 14 local hotels. The project provided…

  13. A Follow-Up Study of Junior College Hotel and Restaurant Education in Florida.

    ERIC Educational Resources Information Center

    Almarode, Richard L.

    This study examines hospitality programs from the enabling legislation in 1961, which provided for an advisory committee to the Hotel and Restaurant Commission on education. Its purpose was to employ a director of the programs and two field representatives or consultants to offer on-the-job assistance to managers and employees in the state's…

  14. Project EXCEL: Sheraton Palace Hotel, Laundry Department. A Beginning Laundry Curriculum.

    ERIC Educational Resources Information Center

    Career Resources Development Center, Inc., San Francisco, CA.

    Project EXCEL is a federally-funded workplace literacy program involving hotel enterprises in the San Francisco (California) Bay area. Its focus is on identification and instruction of literacy skills essential to job success for limited-English-proficient (LEP) workers. Training is intended to enable employees to understand written work orders,…

  15. 'Bee hotels' as tools for native pollinator conservation: a premature verdict?

    PubMed

    MacIvor, J Scott; Packer, Laurence

    2015-01-01

    Society is increasingly concerned with declining wild bee populations. Although most bees nest in the ground, considerable effort has centered on installing 'bee hotels'--also known as nest boxes or trap nests--which artificially aggregate nest sites of above ground nesting bees. Campaigns to 'save the bees' often promote these devices despite the absence of data indicating they have a positive effect. From a survey of almost 600 bee hotels set up over a period of three years in Toronto, Canada, introduced bees nested at 32.9% of sites and represented 24.6% of more than 27,000 total bees and wasps recorded (47.1% of all bees recorded). Native bees were parasitized more than introduced bees and females of introduced bee species provisioned nests with significantly more female larva each year. Native wasps were significantly more abundant than both native and introduced bees and occupied almost 3/4 of all bee hotels each year; further, introduced wasps were the only group to significantly increase in relative abundance year over year. More research is needed to elucidate the potential pitfalls and benefits of using bee hotels in the conservation and population dynamics of wild native bees.

  16. 76 FR 69753 - Agency Information Collection Activities: Proposed Collection; Comment Request, Federal Hotel and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-09

    ...; Comment Request, Federal Hotel and Motel Fire Safety Declaration Form AGENCY: Federal Emergency Management....regulations.gov . FOR FURTHER INFORMATION CONTACT: Bruce Hensler, Fire Program Specialist, FEMA/U.S. Fire... accommodation meeting minimum requirements for protection of life from fire; the list is known as the...

  17. The Matching Process in E-Mentoring: A Case Study in Luxury Hotels

    ERIC Educational Resources Information Center

    Simmonds, David; Lupi, Anne Marie Zammit

    2010-01-01

    Purpose: This paper seeks to examine the effectiveness of an innovative e-mentoring programme introduced in an international group of luxury hotels. Design/methodology/approach: The paper employs the survey method, with quantitative and qualitative data analysis. The research model was developed from a literature review. Findings: While mentoring…

  18. Devolving HRM and HRD to Line managers: The Case of Hilton International's UK Hotels

    ERIC Educational Resources Information Center

    Maxwell, Gillian; Watson, Sandra

    2004-01-01

    This paper explores line manager responsibility for human resource management (HRM) and human resource development (HRD) in an international hotel organisation. The results identify a strong support system for line managers in relation to training and good relations with HR specialists. However, less evident is senior management support coupled…

  19. Perceptions toward the Value of Higher Education for Hotel Professionals in Las Vegas: A Case Study

    ERIC Educational Resources Information Center

    Deel, Gary Lee

    2015-01-01

    This study concerns a qualitative investigation of the views toward higher education and its importance to hospitality career success among hotel professionals in the Las Vegas, Nevada area. Existing literature supported the premise that education may be important to professional career success in several different ways, and that values concerning…

  20. REEP/Hotel Workplace Literacy Project. Final Performance. October 1, 1988-March 31, 1990.

    ERIC Educational Resources Information Center

    Arlington County Public Schools, VA.

    A 1-year workplace literacy program was a joint effort of the Chamber of Commerce, public schools, and seven hotels in Arlington, Virginia. Participants were employees with limited English proficiency. The project resulted in the production of a manual, a video, curricula for housekeeping and food and beverage workers, curricula for more advanced…

  1. 11. 4TH FLOOR, HOTEL SOAP LINE No. 6 TO NORTHEAST, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. 4TH FLOOR, HOTEL SOAP LINE No. 6 TO NORTHEAST, WITH WRAPPER (LEFT), PRESS (CENTER), AND CUTTER (RIGHT, BEHIND CHUTE); BUCKET CONVEYOR AT RIGHT MOVED WASTE FROM PRESS TO 5TH FLOOR FOR RE-MANUFACTURE - Colgate & Company Jersey City Plant, Building No. B-14, 54-58 Grand Street, Jersey City, Hudson County, NJ

  2. The Role of Mathematics in Hotel, Catering and Institutional Management HND and FM Courses.

    ERIC Educational Resources Information Center

    Roberts, I. M.; Ineson, Elizabeth M.

    1980-01-01

    Research was conducted from the viewpoints of students, teaching staff, and industry in relation to mathematical abilities of students taking hotel, catering, and institutional management courses, content and structure of Higher National Diploma and Final Membership courses, industrial applications, and learning strategies. (CT)

  3. SARS: retrospective cohort study among German guests of the Hotel 'M', Hong Kong.

    PubMed

    Radun, D; Niedrig, M; Ammon, A; Stark, K

    2003-12-01

    Hong Kong played a pivotal role in the international spread of the Severe Acute Respiratory Syndrome (SARS): a doctor who spent the night of 21-22 February 2003 at Hotel 'M' was identified as the index case for four national and international clusters of SARS. In parallel to the international collaborative study led by WHO and United States, a retrospective study on the cohort of German persons staying at Hotel 'M' was conducted. The inclusion criteria covered a period from 21 February to 3 March 2003 to allow the detection of cases possibly due to environmental contamination. In the twenty-one German guests traced as having stayed at Hotel "M" during this period, one case of laboratory confirmed SARS was found. The case history suggests that close vicinity to the index patient may have played a role in transmission. In line with findings of environmental investigations in the hotel, environmental contamination should be considered as a possible source of infection. PMID:14724331

  4. Occupations in the Hotel Tourist Sector within the European Community. A Comparative Analysis.

    ERIC Educational Resources Information Center

    Peroni, Giovanni; Guerra, Duccio

    This report contains a directory of job profiles in the tourist/hotel sector that is based on seven national monographs. It provides an instrument for comparing factors that characterize practitioners working in the sector in Germany, Spain, France, Greece, Italy, Portugal, and the United Kingdom. A methodological note discusses study objectives,…

  5. Basic Skills in the Hotel & Food Service Industries. Workforce & Workplace Literacy Series. Revised.

    ERIC Educational Resources Information Center

    BCEL Brief, 1993

    1993-01-01

    This report contains a list of 21 contacts and 9 references concerned with workplace literacy programs in the hotel and food service industries. Each listing includes addresses and telephone numbers, prices if applicable, and a brief description of the resource or materials. The materials listed are mostly reports of workplace literacy projects in…

  6. ESL for Hotel/Hospitality Industry. Level: Advanced Beginner/Intermediate.

    ERIC Educational Resources Information Center

    Western Suffolk County Board of Cooperative Educational Services, Northport, NY.

    This document contains 16 lesson plans for an advanced beginning and intermediate course in work-related English for non-English- or limited-English-speaking entry-level employees in the hotel and hospitality industry. Course objectives are as follows: helping participants understand and use job-specific vocabulary; receive and understand…

  7. Comparison of the channelized Hotelling and human observers for lesion detection in hepatic SPECT imaging

    NASA Astrophysics Data System (ADS)

    King, Michael A.; de Vries, Daniel J.; Soares, Edward J.

    1997-04-01

    The relative rankings of the channelized Hotelling model observer were compared to those of the human observers for the task of detecting 'hot' tumors in simulated hepatic SPECT slices. The signal-to-noise ratios (SNRs) were determined using eighty images for each of three slice locations. The acquisition and processing strategies investigated were: (1) imaging solely primary photons, (2) imaging primary plus scatter within a 20% symmetric energy window for Tc-99m, (3) imaging with primary plus an elevated amount of scatter, (4) energy-spectrum-based scatter compensation of the primary plus scatter acquisitions, and (5) energy-spectrum-based scatter compensation of the acquisitions with an elevated amount of scatter. Both square non-overlapping channels (SQR), and overlapping difference- of-Gaussian channels (DOG) were incorporated into the Hotelling model observer. When the scatter compensation results were excluded, both channelized Hotelling model observers exhibited a strong correlation with the rankings of the human-observers. With the inclusion of the scatter compensation results, only with the DOG model observer was the null-hypothesis of no correlation rejected at the p equals 0.05 level. It is concluded that further investigation of the channel model used with the Hotelling observer is indicated to determine if better correlation can be obtained.

  8. Colonization of Legionella species in Turkish baths in hotels in Alanya, Turkey.

    PubMed

    Erdogan, Haluk; Arslan, Hande

    2015-05-01

    This study evaluated the prevalence of Legionella species in water samples collected from Turkish baths in hotels in Alanya, Turkey, from August 2003 to September 2013. Water samples were collected in 100-mL sterile containers and then concentrated by filtration. Heat treatment was used to eliminate other microorganisms from the samples, which were then spread on Legionella-selective-buffered charcoal yeast extract alpha (BCYE-α) agar and on BCYE-α agar supplemented with glycine, vancomycin, polymyxin, and cycloheximide. Cysteine-dependent colonies were identified by latex agglutination. In total, 135 samples from 52 hotels with Turkish baths were evaluated. Legionella species were identified in 11/52 (21.2%) hotels and 18/135 (13.3%) samples. The most frequently isolated species was Legionella pneumophila, with most isolates belonging to serogroups 6 (55.6%) and 1 (22.2%). The colony count was <100 colony-forming units (CFU) mL(-1) in nine samples, from 100 to 1000 CFU mL(-1) in six samples, and >1000 CFU mL(-1) in three samples. These findings suggest that the hot water systems of Turkish baths in hotels must be viewed as a possible source of travel-associated Legionnaires' disease, and preventative measures should be put in place.

  9. Analyzing the Training and Internship Needs Assessment of Verbal Communication Skills amongst Hotel Practitioners

    ERIC Educational Resources Information Center

    Rahim, Suzana Ab.; Tazijan, Farina

    2011-01-01

    There is a need to expose the learners in the hospitality industry to real workplace requirement in terms of communication skills. In view of its importance, human resource managers, researchers and educators in the field of hospitality management or the hotel practitioners have to pay more serious attention to it. Thus, it is pertinent that both…

  10. Geothermal district-heating potential for casinos/hotels in Reno, Nevada

    SciTech Connect

    Not Available

    1981-11-30

    Results from the pre-feasibility study of a geothermal district heating system for greater Reno and the pre-feasibility study of providing geothermal heat to casinos/hotels located in downtown Reno by connection to the proposed district heating system (DHS) are combined. Geothermal sources were selected from published data. Potential users were selected from aerial and city planning maps, and published building and demographic information. Energy consumption data from the electric and gas utility was matched with consumption information from surveys of representative buildings by category and climatic data. As an example, a written survey was mailed to the casino/hotels and two on-site visits were made. Retrofit methodology and cost were examined for the casino/hotels and representative buildings. Based on the pre-feasibility studies, a geothermal district heating system for Reno appears technically and economically feasible. Furthermore, additional economic savings are achieved when the Reno casinos/hotels are connected to the DHS. Steamboat Hot Springs and a geothermal area east of downtown are the most promising geothermal sources for the DHS. The City of Reno has a large yearly heat load with an average heating degree days per year of 6022/sup 0/F days and a heating season greater than eight months.

  11. Family Hotel Businesses: Strategic Planning and the Need for Education and Training

    ERIC Educational Resources Information Center

    Peters, Mike; Buhalis, Dimitrios

    2004-01-01

    Small businesses dominate the tourism and hospitality industry worldwide and are of critical importance for the competitiveness of destinations. Small family hotel businesses are characterised by a number of specific business processes which generate particular training and educational needs. It is increasingly clear that small businesses are not…

  12. "Front Desk? Send Me a Computer!" The Hotel and Tourism Sector: New Technology Spawns a Revolution in Travel Jobs.

    ERIC Educational Resources Information Center

    World of Work, 1997

    1997-01-01

    The computer and new technologies are revolutionizing the hotel, catering, and tourism businesses. There is consensus that formal training for these changes falls short of new requirements and that schools are having difficulty keeping up. (JOW)

  13. Intracellular Na+ regulates epithelial Na+ channel maturation.

    PubMed

    Heidrich, Elisa; Carattino, Marcelo D; Hughey, Rebecca P; Pilewski, Joseph M; Kleyman, Thomas R; Myerburg, Mike M

    2015-05-01

    Epithelial Na(+) channel (ENaC) function is regulated by the intracellular Na(+) concentration ([Na(+)]i) through a process known as Na(+) feedback inhibition. Although this process is known to decrease the expression of proteolytically processed active channels on the cell surface, it is unknown how [Na(+)]i alters ENaC cleavage. We show here that [Na(+)]i regulates the posttranslational processing of ENaC subunits during channel biogenesis. At times when [Na(+)]i is low, ENaC subunits develop mature N-glycans and are processed by proteases. Conversely, glycan maturation and sensitivity to proteolysis are reduced when [Na(+)]i is relatively high. Surface channels with immature N-glycans were not processed by endogenous channel activating proteases, nor were they sensitive to cleavage by exogenous trypsin. Biotin chase experiments revealed that the immature surface channels were not converted into mature cleaved channels following a reduction in [Na(+)]i. The hypothesis that [Na(+)]i regulates ENaC maturation within the biosynthetic pathways is further supported by the finding that Brefeldin A prevented the accumulation of processed surface channels following a reduction in [Na(+)]i. Therefore, increased [Na(+)]i interferes with ENaC N-glycan maturation and prevents the channel from entering a state that allows proteolytic processing. PMID:25767115

  14. Performance assessment of AS-SBR and UF-MBR for hotel wastewater treatment.

    PubMed

    Libralato, G; Volpi Ghirardini, A; Avezzù, F

    2009-01-01

    A large number of tourist structures in Venice (Italy) have small sized on-site treatment systems for their wastewater. Due to its historical characteristics, the city has no public sewerage system and untreated hotel wastewater represents a serious hazard for its lagoon environment. This study focused on the wastewater facilities installed in two hotels adopting an Activated Sludge Sequencing Batch Reactor (AS-SBR) and an Ultra-Filtration Membrane Biological Reactor (UF-MBR). Their performance was checked in terms of both traditional physico-chemical and ecotoxicological parameters, the importance of which has recently been recognised by EU regulatory dispositions and OSPAR indications. Acute and sub-chronic endpoints were both considered on a whole effluent toxicity basis by means of Vibrio fischeri and Crassostrea gigas, respectively. The two months monitoring survey evidenced that the UF-MBR was more efficient than the AS-SBR in providing high-quality discharges under both chemical and ecotoxicological viewpoints. PMID:19809133

  15. Biogas from bio-waste-potential for an ecological waste and energy management in resort hotels

    SciTech Connect

    Steinbach, D.; Schultheis, A.

    1996-12-31

    This paper gives an overview about waste management in holiday resorts. The objective is to determine the composition of waste and the specific waste quantities per guest. This data represents the basis for planning recycling measures and corresponding treatment facilities. The sorting analyses show the great potential of organic material suitable for biological treatment. Because of the characteristics (water content, structure) of these organic materials, composting is not as suitable as fermentation. Fermentation tests with hotel bio-waste turned out a much higher rate of biogas compared with communal bio-waste. Until now, biogas as a possibility of regenerative energy, has not been taken into consideration for big hotels or holiday resorts. Using biogas as an additional source of energy and the fermentation products as fertilizer would be a further step to an ecologically beneficial tourism.

  16. The Impact of e-Customer Relationship Marketing in Hotel Industry

    NASA Astrophysics Data System (ADS)

    Samanta, Irene

    The present research investigates the extent to which Greek hotels had developed the electronic customer relationship marketing (E-CRM). The study verifies the practices that frequently appear in relationship marketing process within online operations or whether their Internet presence mainly depends on the basic actions of "supplying information" and "reservations". Also, it investigates the effects of e-CRM system on customer loyalty and satisfaction as well as the impact of relationship marketing practices to customer retention and acquisition. They have understood the importance of using electronic channels instead of traditional ones to implement their marketing strategies. Thus, e-crm system has assisted hotel business to manage more effectively their reservations and serve their customers as fast and as effective as possible. They did not seem to apply many of the relationship marketing strategies to emphasize customer retention and continual satisfaction because of difficulties in staff training.

  17. 3,000 kW Suginoi Hotel geothermal power plant

    SciTech Connect

    Kudo, Kisumi

    1996-05-01

    The Suginoi Hotel is located 200 m above sea level, in Beppu City, which is one of the largest hot spring resort area in Japan. In this hotel, there are some unique hot spring baths, which are interesting to visitors. In Beppu, there are numerous hot springs, some are call {open_quotes}Jigoku{close_quotes} (Hells). The main attraction in Beppu are the hell-like spots created by hot springs such as the Torando Hell, which erupt to a heights of more than 50 meters, The Blood Pond Hell which is bloody red due to red clay content. In yield, these hot springs rank second in the world next to those of Yellowstone National Park in the USA.

  18. Improving service quality in NHS Trust hospitals: lessons from the hotel sector.

    PubMed

    Desombre, T; Eccles, G

    1998-01-01

    This article looks to review recent practice undertaken within the UK hotel sector to improve customer service, and suggests ideals that could be implemented within National Health (NHS) Trust hospitals. At a time of increasing competition, hotel firms are using service enhancement as a means to gain competitive advantage, and therefore developing a range of techniques to measure levels of service quality improvement. With continued change in the health service, where greater focus now lies with patient satisfaction, so there is a requirement for managers to adapt techniques presently being offered in other service industries to improve levels of customer service and ensure patients are targeted to define their levels of satisfaction. PMID:10177367

  19. Geothermal district heating and cooling of hotel/casinos in downtown Reno, Nevada

    SciTech Connect

    Cerci, Y.; Kanoglu, M.; Cengel, Y.A.; Turner, R.H.

    1996-12-31

    In this paper, potential revenues from the proposed geothermal district heating/cooling system for the hotel/casino complexes in downtown Reno, Nevada are estimated by analyzing their actual electricity and natural gas bills during 1993 through 1994. The geothermal system appears to be feasible, and financially very attractive. The geothermal district system can meet the entire heating and cooling requirements of the hotel/casinos, generating total potential revenues of $3,486,000 per year. Also, other buildings around the downtown area such as Saint Mary`s Hospital, several motels, business complexes, Washoe County School District Building, and even the UNR campus will add extra potential revenues, if these buildings are connected to the geothermal grid. Since most buildings around the downtown use central heating and cooling system, the retrofit costs for the both system should be minimal.

  20. Evaluation of the Implementation of Good Handling Practices in Food and Beverage Areas of Hotels.

    PubMed

    Serafim, A L; Hecktheuer, L H R; Stangarlin-Fiori, L; Medeiros, L B; Martello, L; Machado, C E

    2015-11-01

    Because of the major international-level events that have recently been held in Brazil, concerns about the sensory and hygienic-sanitary conditions of food have increased. The objective of this study was to evaluate the implementation of good handling practices in food and beverage areas of hotels, with and without outsourced professional intervention. We evaluated 19 food and beverage areas in hotels in Porto Alegre, Rio do Sul, Brazil, using a checklist that was developed by a municipal surveillance team based on existing laws for good handling practices. The evaluation was done by a skilled professional in the food safety area on two occasions, at the beginning of the study (January to May 2013) and at the end (July to November 2014), and the establishments were classified as good, regular, or poor. After the baseline evaluation, an action plan listing the noncompliance found at each location was given to those responsible for the establishments, and a period of 1 year 6 months was stipulated for improvements to be made. In the repeat evaluation, those responsible for the establishments were asked whether they had hired an outsourced professional to assist them in the improvements. The hotels showed improvement during the repeat evaluation, but a significant increase in the percentage of overall adequacy was seen only in the food and beverages areas of the 12 hotels that used the intervention of an outsourced professional. The better percentage of adequacy in establishments with outsourced professional intervention underlines the importance of an external and impartial view of routine activities in the implementation of good handling practices.

  1. Evaluation of the Implementation of Good Handling Practices in Food and Beverage Areas of Hotels.

    PubMed

    Serafim, A L; Hecktheuer, L H R; Stangarlin-Fiori, L; Medeiros, L B; Martello, L; Machado, C E

    2015-11-01

    Because of the major international-level events that have recently been held in Brazil, concerns about the sensory and hygienic-sanitary conditions of food have increased. The objective of this study was to evaluate the implementation of good handling practices in food and beverage areas of hotels, with and without outsourced professional intervention. We evaluated 19 food and beverage areas in hotels in Porto Alegre, Rio do Sul, Brazil, using a checklist that was developed by a municipal surveillance team based on existing laws for good handling practices. The evaluation was done by a skilled professional in the food safety area on two occasions, at the beginning of the study (January to May 2013) and at the end (July to November 2014), and the establishments were classified as good, regular, or poor. After the baseline evaluation, an action plan listing the noncompliance found at each location was given to those responsible for the establishments, and a period of 1 year 6 months was stipulated for improvements to be made. In the repeat evaluation, those responsible for the establishments were asked whether they had hired an outsourced professional to assist them in the improvements. The hotels showed improvement during the repeat evaluation, but a significant increase in the percentage of overall adequacy was seen only in the food and beverages areas of the 12 hotels that used the intervention of an outsourced professional. The better percentage of adequacy in establishments with outsourced professional intervention underlines the importance of an external and impartial view of routine activities in the implementation of good handling practices. PMID:26555528

  2. 10. 4TH FLOOR, HOTEL SOAP LINE No. 6 TO SOUTHWEST, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. 4TH FLOOR, HOTEL SOAP LINE No. 6 TO SOUTHWEST, WITH AUTOMATIC CUTTER (LEFT), PRESS (CENTER), AND WRAPPER (RIGHT); LARGE CHUTE AT CENTER FROM 5TH FLOOR BINS TO 3RD FLOOR SOAP MILLS; OVERHEAD AND FLOOR (LOWER RIGHT) FINISHED GOODS CONVEYORS TO G BLOCK (HAER NO. NJ-71-NN) - Colgate & Company Jersey City Plant, Building No. B-14, 54-58 Grand Street, Jersey City, Hudson County, NJ

  3. What is a health worker? How spa therapists in a Norwegian health hotel understand their work.

    PubMed

    Anderssen, Jorid

    2016-01-01

    In Norway, as in many other wealthy countries, the number of health-related services that are being offered outside of the health sector is increasing. The present paper is based on qualitative interviews that were conducted with providers of health-related services at a commercial health hotel in Norway. The hotel is marketed as a health hotel - that is, a place for people with health problems and for those who need relaxation and an escape from their stressful everyday lives. The paper discusses whether the providers of this kind of service consider it a health service or if they distinguish and distance themselves from the health system. The interviews showed that they consider themselves health workers and refer to themselves as therapists. Even though they use therapy in the health sector as a model, they distinguish themselves from therapists in the health sector. They do not want to treat what they call sick people. Most of their therapy is directed toward cultivating or improving people's bodies and souls. These service providers think that they contribute to improving their guests' health by teaching them how to take care of themselves; enjoying oneself (for instance, by receiving skin treatment or a massage) is an important aspect of good health. According to the therapists, modern-day women, in particular, are often worn-out, and they deserve, and are entitled, to enjoy themselves. In these ways, the therapists use health to legitimize their services, and they challenge the current understanding of health. PMID:26324995

  4. Integration of spatio-temporal contrast sensitivity with a multi-slice channelized Hotelling observer

    NASA Astrophysics Data System (ADS)

    Avanaki, Ali N.; Espig, Kathryn S.; Marchessoux, Cedric; Krupinski, Elizabeth A.; Bakic, Predrag R.; Kimpe, Tom R. L.; Maidment, Andrew D. A.

    2013-03-01

    Barten's model of spatio-temporal contrast sensitivity function of human visual system is embedded in a multi-slice channelized Hotelling observer. This is done by 3D filtering of the stack of images with the spatio-temporal contrast sensitivity function and feeding the result (i.e., the perceived image stack) to the multi-slice channelized Hotelling observer. The proposed procedure of considering spatio-temporal contrast sensitivity function is generic in the sense that it can be used with observers other than multi-slice channelized Hotelling observer. Detection performance of the new observer in digital breast tomosynthesis is measured in a variety of browsing speeds, at two spatial sampling rates, using computer simulations. Our results show a peak in detection performance in mid browsing speeds. We compare our results to those of a human observer study reported earlier (I. Diaz et al. SPIE MI 2011). The effects of display luminance, contrast and spatial sampling rate, with and without considering foveal vision, are also studied. Reported simulations are conducted with real digital breast tomosynthesis image stacks, as well as stacks from an anthropomorphic software breast phantom (P. Bakic et al. Med Phys. 2011). Lesion cases are simulated by inserting single micro-calcifications or masses. Limitations of our methods and ways to improve them are discussed.

  5. Key facilitators and best practices of hotel-style room service in hospitals.

    PubMed

    Sheehan-Smith, Lisa

    2006-04-01

    This qualitative study sought to identify the features, advantages, and disadvantages of hotel-style room service; the barriers to, and facilitators for, implementing the process; and "best practices." The study took place in four heterogeneous hospitals. Participants included hospital administrators, managers, and room-service employees. Data-collection methods included semi-structured interviews, observations, and document analysis. Common features of hotel-style room service were meal delivery within 30 to 45 minutes, a restaurant-style menu, procedures to feed ineligible patients, tray assembly on demand, scripting, and waitstaff uniforms for room-service employees. The major barrier to implementing room service was obtaining nursing support. The key facilitators were the hospital's service-oriented culture, using a multidisciplinary planning team, engaging nursing departments early in the planning stages, and intense customer-service training of room-service employees. The overwhelming advantage was patients' control over their food choices. The main disadvantage was cost. Initial best practices in hotel-style room service include: (a) taking a multidisciplinary team approach for developing and implementing the process, (b) customer-service training, (c) using a customer-driven menu, (d) wearing waitstaff uniforms, and (e) using carts with airpots for dispensing hot beverages. PMID:16567154

  6. Employee Relations. A Guide and Reference Book for Those Involved or Training to Be Involved in Employee Relations in the Hotel and Catering Industry. Seventh Edition.

    ERIC Educational Resources Information Center

    Martin, Rodney; Hayter, Roy, Ed.

    This guide and reference book is designed to help those involved or training to be involved in employee relations in the hotel and catering industry. Chapter 1 attempts to define employee relations. Chapter 2 describes the institutions and parties involved in employee relations in the hotel and catering industry. The focus of chapter 3 is on…

  7. The world's largest photovoltaic hotel roof project: A case study of the Mauna Lani Bay Hotel PowerGuard{reg_sign} system

    SciTech Connect

    Shugar, D.S.; Saito, R.

    1999-07-01

    This paper presents design, performance, and economic feasibility information of the Mauna Lani Bay Hotel and Bungalows 100 KWp photovoltaic (PV) roofing system supplied by PowerLight Corporation. The system, called PowerGuard{reg_sign}, was installed in May 1998. Several months of operating data are presented together with information regarding the value of the system. The project achieved several milestones for building-integrated PV (BIPV), such as (1) the largest BIPV project in the USA, (2) the largest PV project in Hawaii by a factor of five, (3) a demonstration of the practicality for constructing BIPV in a premium resort location during normal operations, and (4) a strong economic return for BIPV in tropical applications.

  8. [To smoke or not to smoke, in restaurants, hotels, and bars].

    PubMed

    López-Antuñano, Francisco Javier; Tovar-Guzmán, Victor José

    2002-01-01

    A MEDLINE search was conducted to identify relevant references, to review the information on adverse effects of tobacco smoking and environmental tobacco smoke (ETS). Occupational exposure to ETS causes significant damages to food industry workers. High levels of mutagenic substances have been demonstrated in restaurant air as well as in the urine samples from those workers. Exposition to 3-aminophenyl, a hemoglobin-associated carcinogen. The best way to protect these workers is the reduction of tobacco smoking in restaurants, hotels, bars and taverns. In restaurant workers, ETS attributable risk for lung cancer is evident.

  9. Tuberculosis screening among homeless persons with AIDS living in single-room-occupancy hotels.

    PubMed

    Layton, M C; Cantwell, M F; Dorsinville, G J; Valway, S E; Onorato, I M; Frieden, T R

    1995-11-01

    Congregate facilities for homeless persons with the acquired immunodeficiency syndrome (AIDS) are often endemic for tuberculosis. We evaluated tuberculosis screening methods at single-room-occupancy hotels housing persons with AIDS. Residents were screened by cross matching the New York City Tuberculosis Registry, interviewing for tuberculosis history, skin testing, and chest radiography. Cases were classified as either previously or newly diagnosed. Among the 106 participants, 16 (15%) previously diagnosed tuberculosis cases were identified. Participants' tuberculosis histories were identified by the questionnaire (100%) or by registry match (69%). Eight participants (50%) were noncompliant with therapy. These findings prompted the establishment of a directly observed therapy program on site.

  10. Use of the Hotelling observer to optimize image reconstruction in digital breast tomosynthesis.

    PubMed

    Sánchez, Adrian A; Sidky, Emil Y; Pan, Xiaochuan

    2016-01-01

    We propose an implementation of the Hotelling observer that can be applied to the optimization of linear image reconstruction algorithms in digital breast tomosynthesis. The method is based on considering information within a specific region of interest, and it is applied to the optimization of algorithms for detectability of microcalcifications. Several linear algorithms are considered: simple back-projection, filtered back-projection, back-projection filtration, and [Formula: see text]-tomography. The optimized algorithms are then evaluated through the reconstruction of phantom data. The method appears robust across algorithms and parameters and leads to the generation of algorithm implementations which subjectively appear optimized for the task of interest. PMID:26702408

  11. [To smoke or not to smoke, in restaurants, hotels, and bars].

    PubMed

    López-Antuñano, Francisco Javier; Tovar-Guzmán, Victor José

    2002-01-01

    A MEDLINE search was conducted to identify relevant references, to review the information on adverse effects of tobacco smoking and environmental tobacco smoke (ETS). Occupational exposure to ETS causes significant damages to food industry workers. High levels of mutagenic substances have been demonstrated in restaurant air as well as in the urine samples from those workers. Exposition to 3-aminophenyl, a hemoglobin-associated carcinogen. The best way to protect these workers is the reduction of tobacco smoking in restaurants, hotels, bars and taverns. In restaurant workers, ETS attributable risk for lung cancer is evident. PMID:12055736

  12. The ambivalence of the work of the hotel managers: an approach to ergonomics.

    PubMed

    de Gois Leite, Cyntia Maria; de Carvalho, Ricardo Josématos

    2012-01-01

    This article uses the contributions of ergonomics to understand the work performed by hotel managers. The concern to understand the job of managers is something new in the ergonomics and few studies address this issue, especially in what concerns the work of hotel managers and its aspects of performance and health, which is the focus of this article. Through a literature review on the subject, it is sought to understand the managers' work activity, the impacts on their health and their organizational performance, as managers take an ambivalent position in organizations, since they have to deal directly with the demands of upper and lower hierarchies in a context of high competition, organizational changes and user requirements. It is then inferred there is a risk of increased work density for managers, bringing negative consequences to their health and organizational performance. This phenomenon, still poorly covered by ergonomics, contributes to a certain invisibility of the manager's work in society as a whole, when the manager may suffer from health problems, which are also common in certain populations of workers who do not take the managerial function. PMID:22317647

  13. Precarious employment, working hours, work-life conflict and health in hotel work.

    PubMed

    McNamara, Maria; Bohle, Philip; Quinlan, Michael

    2011-01-01

    Precarious or temporary work is associated with adverse outcomes including low control over working hours, work-life conflict and stress. The rise in precarious employment is most marked in the service sector but little research has been done on its health effects in this sector. This study compares permanent and temporary workers in the hotel industry, where working hours are highly variable. Survey data from 150 workers from eight 3-Star hotels in urban and regional areas around Sydney were analyzed. Forty-five per cent were male and 52 per cent were female. Fifty four per cent were permanent full-time and 46 per cent were temporary workers. The effects of employment status on perceived job security, control over working hours, and work-life conflict are investigated using PLS-Graph 3.0. The effects of control over working hours, on work-life conflict and subsequent health outcomes are also explored. Temporary workers perceived themselves as less in control of their working hours, than permanent workers (β = .27). However, they also reported lower levels of work intensity (β = .25) and working hours (β = .38). The effects of low hours control (β = .20), work intensity (β = .29), and excessive hours (β = .39) on work-life conflict (r² = .50), and subsequent health effects (r² = .30), are illustrated in the final structural equation model. PMID:20643398

  14. A Dynamic Intrusion Detection System Based on Multivariate Hotelling's T2 Statistics Approach for Network Environments

    PubMed Central

    Avalappampatty Sivasamy, Aneetha; Sundan, Bose

    2015-01-01

    The ever expanding communication requirements in today's world demand extensive and efficient network systems with equally efficient and reliable security features integrated for safe, confident, and secured communication and data transfer. Providing effective security protocols for any network environment, therefore, assumes paramount importance. Attempts are made continuously for designing more efficient and dynamic network intrusion detection models. In this work, an approach based on Hotelling's T2 method, a multivariate statistical analysis technique, has been employed for intrusion detection, especially in network environments. Components such as preprocessing, multivariate statistical analysis, and attack detection have been incorporated in developing the multivariate Hotelling's T2 statistical model and necessary profiles have been generated based on the T-square distance metrics. With a threshold range obtained using the central limit theorem, observed traffic profiles have been classified either as normal or attack types. Performance of the model, as evaluated through validation and testing using KDD Cup'99 dataset, has shown very high detection rates for all classes with low false alarm rates. Accuracy of the model presented in this work, in comparison with the existing models, has been found to be much better. PMID:26357668

  15. Application of the Hotelling and ideal observers to detection and localization of exoplanets

    PubMed Central

    Caucci, Luca; Barrett, Harrison H.; Devaney, Nicholas; Rodríguez, Jeffrey J.

    2008-01-01

    The ideal linear discriminant or Hotelling observer is widely used for detection tasks and image-quality assessment in medical imaging, but it has had little application in other imaging fields. We apply it to detection of planets outside of our solar system with long-exposure images obtained from ground-based or space-based telescopes. The statistical limitations in this problem include Poisson noise arising mainly from the host star, electronic noise in the image detector, randomness or uncertainty in the point-spread function (PSF) of the telescope, and possibly a random background. PSF randomness is reduced but not eliminated by the use of adaptive optics. We concentrate here on the effects of Poisson and electronic noise, but we also show how to extend the calculation to include a random PSF. For the case where the PSF is known exactly, we compare the Hotelling observer to other observers commonly used for planet detection; comparison is based on receiver operating characteristic (ROC) and localization ROC (LROC) curves. PMID:18059905

  16. Starting Up Your Own Business in the Hotel and Catering Industry. A Self-Help Guide from the Small Business Service of the Hotel and Catering Industry Training Board.

    ERIC Educational Resources Information Center

    Hotel and Catering Training Board, Wembley (England).

    This guide is intended to assist the potential small business proprietor in successfully starting a business in the hotel and catering industry. It is divided into five sections. The first section discusses factors to be considered in making the initial decision of whether or not to seek self-employment in the industry (options, potential…

  17. Development and application of an integrated indoor air quality audit to an international hotel building in Taiwan.

    PubMed

    Kuo, Nae-Wen; Chiang, Hsin-Chen; Chiang, Che-Ming

    2008-12-01

    Indoor air quality (IAQ) has begun to surface as an important issue that affects the comfort and health of people; however, there is little research concerned about the IAQ monitoring of hotels up to now. Hotels are designed to provide comfortable spaces for guests. However, most complaints related to uncomfortable thermal environment and inadequate indoor air quality appear. In addition, microbial pollution can affect the health of tourists such as the Legionnaire's disease and SARS problems. This study is aimed to establish the comprehensive IAQ audit approach for hotel buildings with portable equipment, and one five-star international hotel in Taiwan was selected to exam this integrated approach. Finally, four major problems are identified after the comprehensive IAQ audit. They are: (1) low room temperature (21.8 degrees C), (2) insufficient air exchange rate (<1.5 h(-1)), (3) formaldehyde contamination (>0.02 ppm), and (4) the microbial pollution (total bacteria: 2,624-3,799 CFU/m(3)). The high level of formaldehyde may be due to the emission from the detergent and cleaning agents used for housekeeping. PMID:18095180

  18. Building a University-Community Partnership to Explore Health Challenges among Residents at Extended-Stay Hotels

    ERIC Educational Resources Information Center

    Lewinson, Terri

    2014-01-01

    Extended-stay hotels are housing solutions for some older adults on the fringe of street homelessness. Research indicates that these environments can produce negative health outcomes for older adults. Strategies for managing negative environmental conditions must be identified to help older adults manage health outcomes. This paper describes a…

  19. A Simulated Instructional Model for Educating Mentally Retarded Students for Employment in the Hotel-Motel Industry.

    ERIC Educational Resources Information Center

    McCowan, Richard J.; Mongerson, M. Duane

    Developed by the Campus Laboratory School of the State College at Buffalo, this program description proposes a simulated work environment which could be used to train educable and trainable retardates for hotel/motel aides more effectively and economically than on-the-job training or classroom lecture instruction. The proposed method of…

  20. The Lodging Industry's Image; How the Adults and Teenagers View Hotels and Motels as Employers and Overall.

    ERIC Educational Resources Information Center

    Opinion Research Corp., Princeton, NJ.

    The objective of this study was to obtain an overall evaluation of hotels and motels with specific emphasis on the industry's image as an employer among the general public. Findings are based on a personal interview research survey conducted among 994 men and women 18 years of age and over, and among 622 teenagers living in private households in…

  1. Development and application of an integrated indoor air quality audit to an international hotel building in Taiwan.

    PubMed

    Kuo, Nae-Wen; Chiang, Hsin-Chen; Chiang, Che-Ming

    2008-12-01

    Indoor air quality (IAQ) has begun to surface as an important issue that affects the comfort and health of people; however, there is little research concerned about the IAQ monitoring of hotels up to now. Hotels are designed to provide comfortable spaces for guests. However, most complaints related to uncomfortable thermal environment and inadequate indoor air quality appear. In addition, microbial pollution can affect the health of tourists such as the Legionnaire's disease and SARS problems. This study is aimed to establish the comprehensive IAQ audit approach for hotel buildings with portable equipment, and one five-star international hotel in Taiwan was selected to exam this integrated approach. Finally, four major problems are identified after the comprehensive IAQ audit. They are: (1) low room temperature (21.8 degrees C), (2) insufficient air exchange rate (<1.5 h(-1)), (3) formaldehyde contamination (>0.02 ppm), and (4) the microbial pollution (total bacteria: 2,624-3,799 CFU/m(3)). The high level of formaldehyde may be due to the emission from the detergent and cleaning agents used for housekeeping.

  2. Towards Customer-Driven Management in Hospitality Education: A Case Study of the Higher Hotel Institute, Cyprus.

    ERIC Educational Resources Information Center

    Varnavas, Andreas P.; Soteriou, Andreas C.

    2002-01-01

    Presents and discusses the approach used by the Higher Hotel Institute in Cyprus to incorporate total quality management through establishment of a customer-driven management culture in its hospitality education program. Discusses how it collects and uses service-quality related data from future employers, staff, and students in pursuing this…

  3. Checking into China's cow hotels: have policies following the milk scandal changed the structure of the dairy sector?

    PubMed

    Mo, D; Huang, J; Jia, X; Luan, H; Rozelle, S; Swinnen, J

    2012-05-01

    China's milk scandal is well known for causing the nation's largest food safety crisis and for its effect on thousands of children. Less, however, is known about the effect on the other victim: China's small dairy farmers. Although small backyard producers were not the ones that added melamine to the milk supply, the incomes of dairy farmers fell sharply after the crisis. In response, one of the actions taken by the government was to encourage small dairy producers to check into production complexes that were supposed to supply services, new technologies, and provide for easy/bulk procurement of the milk produced by the cows of the farmers. Because both farmers and their cows were living (and working) away from home, in the rest of the paper we call these complexes cow hotels. In this paper we examine the dynamics of China's dairy production structure before and after the milk scandal. In particular, we seek to gain a better understanding about how China's policies have been successful in encouraging farmers to move from the backyard into cow hotels. We also seek to find if larger or smaller farmers respond differently to these policy measures. Using data from a sample of farmers from dairy-producing villages in Greater Beijing, our empirical analysis finds that 1 yr after the milk scandal, the dairy production structure changed substantially. Approximately one quarter (26%) of the sample checked into cow hotels after the milk scandal, increasing from 2% before the crisis. Our results also demonstrate that the increase in cow hotel production can largely be attributed to China's dairy policies. Finally, our results suggest that the effects of government policy differ across farm sizes; China's dairy policies are more likely to persuade larger farms to join cow hotels. Apparently, larger farms benefit more when they join cow hotels. Overall, these results suggest that during the first year after the crisis, the government policies were effective in moving some of

  4. A Model for Sustainable Building Energy Efficiency Retrofit (BEER) Using Energy Performance Contracting (EPC) Mechanism for Hotel Buildings in China

    NASA Astrophysics Data System (ADS)

    Xu, Pengpeng

    Hotel building is one of the high-energy-consuming building types, and retrofitting hotel buildings is an untapped solution to help cut carbon emissions contributing towards sustainable development. Energy Performance Contracting (EPC) has been promulgated as a market mechanism for the delivery of energy efficiency projects. EPC mechanism has been introduced into China relatively recently, and it has not been implemented successfully in building energy efficiency retrofit projects. The aim of this research is to develop a model for achieving the sustainability of Building Energy Efficiency Retrofit (BEER) in hotel buildings under the Energy Performance Contracting (EPC) mechanism. The objectives include: • To identify a set of Key Performance Indicators (KPIs) for measuring the sustainability of BEER in hotel buildings; • To identify Critical Success Factors (CSFs) under EPC mechanism that have a strong correlation with sustainable BEER project; • To develop a model explaining the relationships between the CSFs and the sustainability performance of BEER in hotel building. Literature reviews revealed the essence of sustainable BEER and EPC, which help to develop a conceptual framework for analyzing sustainable BEER under EPC mechanism in hotel buildings. 11 potential KPIs for sustainable BEER and 28 success factors of EPC were selected based on the developed framework. A questionnaire survey was conducted to ascertain the importance of selected performance indicators and success factors. Fuzzy set theory was adopted in identifying the KPIs. Six KPIs were identified from the 11 selected performance indicators. Through a questionnaire survey, out of the 28 success factors, 21 Critical Success Factors (CSFs) were also indentified. Using the factor analysis technique, the 21 identified CSFs in this study were grouped into six clusters to help explain project success of sustainable BEER. Finally, AHP/ANP approach was used in this research to develop a model to

  5. Individual- and Organization-Level Work-to-Family Spillover Are Uniquely Associated with Hotel Managers' Work Exhaustion and Satisfaction

    PubMed Central

    Lee, Soomi; Davis, Kelly D.; Neuendorf, Claudia; Grandey, Alicia; Lam, Chun Bun; Almeida, David M.

    2016-01-01

    Purpose: Building on the Conservation of Resources theory, this paper examined the unique and interactive associations of negative and positive work-to-family spillover (NWFS and PWFS, respectively) at the individual and organizational level with hotel managers' work exhaustion and satisfaction, beyond job demands and supervisors' leadership style. Design/Methodology/Approach: Guided by the levels of analysis framework, we first tested the unique associations of NWFS and PWFS with emotional exhaustion and job satisfaction at the individual level (571 hotel managers), beyond job demands supervisors' leadership style. Second, using multilevel modeling, we tested the climate effects of NWFS and PWFS on emotional exhaustion and job satisfaction aggregated at the organizational level (41 hotels). Third, we examined the role of the organizational climate of PWFS in the associations of individual-level NWFS with emotional exhaustion and job satisfaction. Findings: Beyond the effects of psychological job demands and supervisor's transformational leadership, at the individual level, hotel managers who experienced higher NWFS than other managers reported more exhaustion and lower job satisfaction, whereas those with higher PWFS reported less exhaustion and higher satisfaction. At the organizational level, working in hotels where the average level of NWFS was higher than other hotels was associated with feeling more exhaustion of the individual members; working in hotels with higher PWFS was associated with feeling less exhaustion. The negative link between individual-level NWFS and job satisfaction was buffered when organization-level PWFS was higher, compared to when it was lower. Originality/Value: This study moves beyond a focus on traditional job characteristics, toward considering individual and organizational experiences in the work-family interface as unique predictors of work exhaustion and satisfaction. Strengths of the study include illuminating organizational work

  6. Consumer Decision-Making Based on Review Websites: Are There Differences Between Choosing a Hotel and Choosing a Physician?

    PubMed Central

    Germeni, Evi; Schulz, Peter J

    2016-01-01

    Background Web users are increasingly encouraged to rate and review consumer services (eg, hotels, restaurants) and, more recently, this is also the case for physicians and medical services. The resemblance in the setup and design of commercial rating websites (CRWs) and Web-based physician rating websites (PRWs) raises the question of whether choice-making processes based on the two types of websites could also be similar. Objective This qualitative study sought to explore the extent to which consumer decision making based on Web-based reviews is the same for consumer services (ie, choice of a hotel) and health services (ie, choice of a pediatrician), while providing an in-depth understanding of potential differences or similarities. Methods Between June and August 2015, we carried out a total of 22 qualitative interviews with young parents residing in the German-speaking part of Switzerland. Participants were invited to complete 2 choice tasks, which involved (1) choosing a hotel based on the commercial Web-based rating website TripAdvisor and (2) selecting a pediatrician based on the PRW Jameda. To better understand consumers’ thought processes, we instructed participants to “think aloud”, namely to verbalize their thinking while sorting through information and reaching decisions. Using a semistructured interview guide, we subsequently posed open-ended questions to allow them to elaborate more on factors influencing their decision making, level of confidence in their final choice, and perceived differences and similarities in their search for a hotel and a physician. All interviews were recorded, transcribed, and analyzed using an inductive thematic approach. Results Participants spent on average 9:57 minutes (standard deviation=9:22, minimum=3:46, maximum=22:25) searching for a hotel and 6:17 minutes (standard deviation=4:47, minimum=00:38, maximum=19:25) searching for a pediatrician. Although the choice of a pediatrician was perceived as more important

  7. Checking into China's cow hotels: have policies following the milk scandal changed the structure of the dairy sector?

    PubMed

    Mo, D; Huang, J; Jia, X; Luan, H; Rozelle, S; Swinnen, J

    2012-05-01

    China's milk scandal is well known for causing the nation's largest food safety crisis and for its effect on thousands of children. Less, however, is known about the effect on the other victim: China's small dairy farmers. Although small backyard producers were not the ones that added melamine to the milk supply, the incomes of dairy farmers fell sharply after the crisis. In response, one of the actions taken by the government was to encourage small dairy producers to check into production complexes that were supposed to supply services, new technologies, and provide for easy/bulk procurement of the milk produced by the cows of the farmers. Because both farmers and their cows were living (and working) away from home, in the rest of the paper we call these complexes cow hotels. In this paper we examine the dynamics of China's dairy production structure before and after the milk scandal. In particular, we seek to gain a better understanding about how China's policies have been successful in encouraging farmers to move from the backyard into cow hotels. We also seek to find if larger or smaller farmers respond differently to these policy measures. Using data from a sample of farmers from dairy-producing villages in Greater Beijing, our empirical analysis finds that 1 yr after the milk scandal, the dairy production structure changed substantially. Approximately one quarter (26%) of the sample checked into cow hotels after the milk scandal, increasing from 2% before the crisis. Our results also demonstrate that the increase in cow hotel production can largely be attributed to China's dairy policies. Finally, our results suggest that the effects of government policy differ across farm sizes; China's dairy policies are more likely to persuade larger farms to join cow hotels. Apparently, larger farms benefit more when they join cow hotels. Overall, these results suggest that during the first year after the crisis, the government policies were effective in moving some of

  8. Integrating wastewater reuse in water resources management for hotels in arid coastal regions - Case Study of Sharm El Sheikh, Egypt.

    PubMed

    Lamei, A; van der Zaag, P; Imam, E

    2009-01-01

    Hotels in arid coastal areas use mainly desalinated water (using reverse osmosis) for their domestic water supply, and treated wastewater for irrigating green areas. Private water companies supply these hotels with their potable and non-potable water needs. There is normally a contractual agreement stating a minimum amount of water that has to be supplied by the water company and that the hotel management has to pay for regardless of its actual consumption ("contracted-for water supply"). Hotels have to carefully analyse their water requirements in order to determine which percentage of the hotel's peak water demand should be used in the contract in order to reduce water costs and avoid the risk of water shortage. This paper describes a model to optimise the contracted-for irrigation water supply with the objective function to minimise total water cost to hotels. It analyses what the contracted-for irrigation water supply of a given hotel should be, based on the size of the green irrigated area on one hand and the unit prices of the different types of water on the other hand. An example from an arid coastal tourism-dominated city is presented: Sharm El Sheikh (Sharm), Egypt. This paper presents costs of wastewater treatment using waste stabilisation ponds, which is the prevailing treatment mechanism in the case study area for centralised plants, as well as aerobic/anaerobic treatment used for decentralised wastewater treatment plants in the case study area. There is only one centralised wastewater treatment plant available in the city exerting monopoly and selling treated wastewater to hotels at a much higher price than the actual cost that a hotel would bear if it treated its own wastewater. Contracting for full peak irrigation demand is the highest total cost option. Contracting for a portion of the peak irrigation demand and complementing the rest from desalination water is a cheaper option. A better option still is to complement the excess irrigation demand

  9. Integrating wastewater reuse in water resources management for hotels in arid coastal regions - Case Study of Sharm El Sheikh, Egypt.

    PubMed

    Lamei, A; van der Zaag, P; Imam, E

    2009-01-01

    Hotels in arid coastal areas use mainly desalinated water (using reverse osmosis) for their domestic water supply, and treated wastewater for irrigating green areas. Private water companies supply these hotels with their potable and non-potable water needs. There is normally a contractual agreement stating a minimum amount of water that has to be supplied by the water company and that the hotel management has to pay for regardless of its actual consumption ("contracted-for water supply"). Hotels have to carefully analyse their water requirements in order to determine which percentage of the hotel's peak water demand should be used in the contract in order to reduce water costs and avoid the risk of water shortage. This paper describes a model to optimise the contracted-for irrigation water supply with the objective function to minimise total water cost to hotels. It analyses what the contracted-for irrigation water supply of a given hotel should be, based on the size of the green irrigated area on one hand and the unit prices of the different types of water on the other hand. An example from an arid coastal tourism-dominated city is presented: Sharm El Sheikh (Sharm), Egypt. This paper presents costs of wastewater treatment using waste stabilisation ponds, which is the prevailing treatment mechanism in the case study area for centralised plants, as well as aerobic/anaerobic treatment used for decentralised wastewater treatment plants in the case study area. There is only one centralised wastewater treatment plant available in the city exerting monopoly and selling treated wastewater to hotels at a much higher price than the actual cost that a hotel would bear if it treated its own wastewater. Contracting for full peak irrigation demand is the highest total cost option. Contracting for a portion of the peak irrigation demand and complementing the rest from desalination water is a cheaper option. A better option still is to complement the excess irrigation demand

  10. Space-Hotel EARLY BIRD - A Visionary Prospect of a Space Station

    NASA Astrophysics Data System (ADS)

    Amekrane, R.; Holze, C.

    2002-01-01

    rachid.amekrane@astrium-space.com/Fax: +49 421 539-24801, cholze@zarm.uni-bremen.de/Fax: The International Space Station was planed for research purposes. In 2001 the first private man, Denis Tito,visited the ISS and the second private man, Mark Shuttleworth is following him. Space pioneers as Wernher von Braun, Sir Arthur C. Clarke had the dream that one day a space station in earth orbit will host tourists. It is evident that the ISS is not designed to host tourists. Therefore this dream is still open. Asking the question "how should a space station should look like to host tourists?" the German Aerospace Society DGLR e.V. initiated in April 2001 a contest under the patronage of Mr. Joerg Feustel-Buechl, the Director of Manned Spaceflight and Microgravity, European Space Agency (ESA). Because the definition and design of living space is the content of architecture the approach was to gather new ideas from young architects in cooperation with space experts. This contest was directed at students of architecture and the task set was to design a hotel for the earth orbit and to accommodate 220 guests. The contest got the name "Early Bird - Visions of a Space Hotel". The results and models of the student's work were shown in an exhibition in Hamburg/Germany, which was open to the public from September 19th till October 20th 2001. During the summer term of 2001 seventeen designs were completed. Having specialists, as volunteers, in the field of space in charge meant that it could be ensured that the designs reflected a certain possibility of being able to be realized. Within this interdisciplinary project both parties learned from each other. The 17 different designs were focused on the expectations and needs of a future space tourist. The design are for sure not feasible today, but the designs are in that sense realistic that they could be built in future. This paper will present the overview of the 17 designs as visions of a future space hotel. The designs used

  11. Space-Hotel Early Bird - An Educational and Public Outreach Approach

    NASA Astrophysics Data System (ADS)

    Amekrane, R.; Holze, C.

    2002-01-01

    In April 2001 the German Aerospace Society DGLR e.V. in cooperation with the Technical University of Darmstadt, Germany initiated an interdisciplinary students contest, under the patronage of Mr. Joerg Feustel-Buechl, the Director of Manned Spaceflight and Microgravity, European Space Agency (ESA), for the summer term 2001. It was directed to graduated architecture students, who had to conceive and design a space-hotel with specific technical, economical and social requirements. The to be developed Space Hotel for a low earth orbit has to accommodate 220 guests. It was of utmost importance that this contest becomes an integral part of the student's tuition and that professors of the different academic and industrial institutions supported the project idea. During the summer term 2001 about fifty students occupied themselves with the topic, "design of an innovative space-hotel". The overall challenge was to create rooms used under microgravity environment, which means to overcome existing definitions and to find a new definition of living space. Because none of the students were able to experience such a room under microgravity they were forced to use the power of their imagination capability. The students attended moreover a number of lectures on different technical subjects focusing on space and went on several space-related excursions. Having specialists, as volunteers, in the field of space in charge meant that it could be ensured that the designs reflected a certain possibility of being able to be realized. Within the summer term seventeen major designs developed from the conceptual status to high sophisticated concepts and later on also to respective models. A competition combined with a public exhibition, that took place within the Annual German Aeronautics and Astronautics Congress, and intense media relations finalized this project. The project idea of "Early Bird - Visions of a Space Hotel" which was developed within six month is a remarkable example, how

  12. Combined Heating and Power Using Microturbines in a Major Urban Hotel

    SciTech Connect

    Sweetser, Richard; Wagner, Timothy; Leslie, Neil; Stovall, Therese K

    2009-01-01

    This paper describes the results of a cooperative effort to install and operate a Cooling, Heating and Power (CHP) System at a major hotel in San Francisco, CA. The packaged CHP System integrated four microturbines, a double-effect absorption chiller, two fuel gas boosters, and the control hardware and software to ensure that the system operated predictably, reliably, and safely. The chiller was directly energized by the recycled hot exhaust from the microturbines, and could be configured to provide either chilled or hot water. As installed, the system was capable of providing up to 227 kW of net electrical power and 142 Refrigeration Tons (RT) of chilled water at a 59oF (15oC) ambient temperature. For the year, the CHP efficiency was 54 percent. Significant lessons learned from this test and verification project are discussed as well as measured performance and economic considerations.

  13. [Prevalence and risk factors of urinary incontinence in female workers of hotels].

    PubMed

    Fontana, L; Falconi, G; Di Martino, T; Iavicoli, I

    2007-01-01

    The International Continence Society defines urinary incontinence (UI) as "a condition in which involuntary loss of urine is a social or hygienic problem and is objectively demonstrable". There are three different jorms of UI. stress urinary incontinence, urge urinary incontinence and mixed incontinence. The aim of this study was to investigate the prevalence of UI in a group of female workers in the hotel sector. The International Consultation on Incontinence Questionnaire Urinary Incontinence short form (ICIQ-UI Short Form) was administered to all female workers and data were collected about age, body mass index, number of vaginal and Caesarean delivery. Results showed a prevalence of UI widely bigger in the plans waitress than in video display terminal workers and suggest the hypothesis that manual handling of loads representing a possible occupational risk for UI.

  14. Thermal disinfection of hotels, hospitals, and athletic venues hot water distribution systems contaminated by Legionella species.

    PubMed

    Mouchtouri, Varvara; Velonakis, Emmanuel; Hadjichristodoulou, Christos

    2007-11-01

    Legionella spp. (> or = 500 cfu liter(-1)) were detected in 92 of 497 water distribution systems (WDS) examined. Thermal disinfection was applied at 33 WDS. After the first and second application of the disinfection procedure, 15 (45.4%) and 3 (9%) positive for remedial actions WDS were found, respectively. Legionella pneumophila was more resistant to thermal disinfection than Legionella non-pneumophila spp. (relative risk [RR]=5.4, 95% confidence intervals [CI]=1-35). WDS of hotels with oil heater were more easily disinfected than those with electrical or solar heater (RR=0.4 95% CI=0.2-0.8). Thermal disinfection seems not to be efficient enough to eliminate legionellae, unless repeatedly applied and in combination with extended heat flushing, and faucets chlorine disinfection.

  15. Development of desiccant based air conditioning for hotels and motels. Final report, phase 1

    SciTech Connect

    Banks, N.J.

    1994-10-01

    This report contains final reports from two phases of field tests: Phase I at the Marriott Courtyard in West Palm Beach, completed in October 1991, and Phase II at the Walt Disney World Swan Hotel in Orlando, completed in August 1993. The goal was to measure the performance and reliability of the desiccant units. The successfull program proved the value of the gas-fired desiccant technology to the hospitality industry. The desiccant units reduced moisture by 15 to 20% relative humidity. Measurements of temperature, humidity, and wallboard moisture content showed a dramatic reduction in the humidity levels experienced prior to installation of the units and in the control areas without desiccants. Moisture damage was kept in check and remodelling due to it was eliminated.

  16. Assessing the Feasibility of Comprehensive Energy Efficiency Upgrades at Potawatomi Carter Casino Hotel

    SciTech Connect

    Karman, Nathan A.

    2014-03-31

    The Forest County Potawatomi Community, a federally-recognized Indian Tribe with a strong commitment to the natural environment, sought and obtained funding to investigate energy efficient improvements to its Potawatomi Carter Casino & Hotel and the adjacent Potawatomi Carter C-Store and Smoke Shop. The resulting energy studies recommended energy conservation measures that would collectively reduce energy use by more than 30% at the facilities and would save approximately $200,000 per year in energy costs. Consistent with its commitment to the natural environment, and to advance its goal of energy independence using Carbon free or Carbon neutral renewable resources, the Community has already begun implementing certain measures and continues to seek funding sources necessary to implement the remaining measures.

  17. The Relationship between Musculoskeletal Symptoms and Work-related Risk Factors in Hotel Workers

    PubMed Central

    2013-01-01

    Objectives To identify work-related musculoskeletal symptoms and any associated work-related risk factors, focusing on structural labor factors among hotel workers. Methods A total of 1,016 hotel workers (620 men and 396 women) were analyzed. The questionnaire surveyed participants’ socio-demographics, health-related behaviors, job-related factors, and work-related musculoskeletal symptoms. Work-related musculoskeletal symptoms were assessed using the Nordic musculoskeletal questionnaire. All analyses were stratified by gender, and multiple logistic regression modeling was used to determine associations between work-related musculoskeletal symptoms and work-related risk factors. Results The risk of developing work-related musculoskeletal symptoms was 1.9 times higher among male workers in the kitchen department than males in the room department (OR = 1.92, 95% CI = 1.03-3.79), and 2.5 times higher among male workers with lower sleep satisfaction than those with higher sleep satisfaction (OR = 2.52, 95% CI = 1.57-4.04). All of the aforementioned cases demonstrated a statistically significant association with work-related musculoskeletal symptoms. Moreover, the risk of developing work-related musculoskeletal symptoms was 3.3 times higher among female workers aged between 30 and 34 than those aged 24 or younger (OR = 3.32, 95% CI = 1.56-7.04); 0.3 times higher among females in the back office department than those in the room department (OR = 0.34, 95% CI = 0.12-0.91); 1.6 times higher among females on shift schedules than those who were not (OR = 1.60, 95% CI = 1.02-2.59); 1.8 times higher among females who performed more intensive work than those who performed less intensive work (OR = 1.88, 95% CI = 1.17-3.02), and; 2.1 times higher among females with lower sleep satisfaction than those with higher sleep satisfaction (OR = 2.17, 95% CI = 1.34-3.50). All of the aforementioned cases also displayed a statistically significant association with work

  18. Thermal disinfection of hotels, hospitals, and athletic venues hot water distribution systems contaminated by Legionella species.

    PubMed

    Mouchtouri, Varvara; Velonakis, Emmanuel; Hadjichristodoulou, Christos

    2007-11-01

    Legionella spp. (> or = 500 cfu liter(-1)) were detected in 92 of 497 water distribution systems (WDS) examined. Thermal disinfection was applied at 33 WDS. After the first and second application of the disinfection procedure, 15 (45.4%) and 3 (9%) positive for remedial actions WDS were found, respectively. Legionella pneumophila was more resistant to thermal disinfection than Legionella non-pneumophila spp. (relative risk [RR]=5.4, 95% confidence intervals [CI]=1-35). WDS of hotels with oil heater were more easily disinfected than those with electrical or solar heater (RR=0.4 95% CI=0.2-0.8). Thermal disinfection seems not to be efficient enough to eliminate legionellae, unless repeatedly applied and in combination with extended heat flushing, and faucets chlorine disinfection. PMID:17980243

  19. Live from the Mars Hotel - Space Locations and the Film Industry

    NASA Astrophysics Data System (ADS)

    Sivier, D.

    Space exploration is the subject of intense media interest in a way unparalleled in any other branch of science. It is the subject of countless films and television programmes, both fact and fiction, many using original footage from space. Astronauts have broadcast live from the Moon, and TV journalists have travelled to Mir, similar to the use of exotic terrestrial locations for filming by professional film crews. Although prohibitively expensive at the moment, the next generation of spacecraft may lower launch costs to an affordable level, so that space locations become competitive against computer graphics and model work. The construction of orbital hotels will create the demand for human interest stories similar to those set in holiday locations like the south of France and Italy made just after the Second World War, at a time when mass tourism on foreign holidays was just beginning, aided by the development of large transport aircraft able to cater to the demand for mass flight.

  20. A food-borne outbreak of cryptosporidiosis among guests and staff at a hotel restaurant in Stockholm county, Sweden, September 2008.

    PubMed

    Insulander, M; de Jong, B; Svenungsson, B

    2008-12-18

    In September 2008, 21 cases of cryptosporidiosis occurred among guests and staff at a wedding reception in a hotel restaurant in Stockholm county, Sweden. The most probable source of the outbreak was bearnaise sauce containing chopped fresh parsley. PMID:19094915

  1. Identification of the infectious source of an unusual outbreak of histoplasmosis, in a hotel in Acapulco, state of Guerrero, Mexico.

    PubMed

    Taylor, Maria Lucia; Ruíz-Palacios, Guillermo M; del Rocío Reyes-Montes, María; Rodríguez-Arellanes, Gabriela; Carreto-Binaghi, Laura E; Duarte-Escalante, Esperanza; Hernández-Ramírez, Aurora; Pérez, Armando; Suárez-Alvarez, Roberto O; Roldán-Aragón, Yuri A; Romero-Martínez, Rafael; Sahaza-Cardona, Jorge H; Sifuentes-Osornio, José; Soto-Ramírez, Luis E; Peña-Sandoval, Gabriela R

    2005-09-01

    Three isolates of Histoplasma capsulatum were identified from mice lung, liver, and spleen inoculated with soil samples of the X hotel's ornamental potted plants that had been fertilized with organic material known as compost. The presence of H. capsulatum in the original compost was detected using the dot-enzyme-linked immunosorbent assay. Nested-PCR, using a specific protein Hcp100 coding gene sequence, confirmed the fungal identification associated with an unusual histoplasmosis outbreak in Acapulco. Although, diversity between the H. capsulatum isolate from the hotel and some clinical isolates from Guerrero (positive controls) was observed using random amplification of polymorphic DNA based-PCR, sequence analyses of H-anti and ole fragment genes revealed a high homology (92-99%) between them. PMID:16061362

  2. Genetic hotels for the standard genetic code: evolutionary analysis based upon novel three-dimensional algebraic models.

    PubMed

    José, Marco V; Morgado, Eberto R; Govezensky, Tzipe

    2011-07-01

    Herein, we rigorously develop novel 3-dimensional algebraic models called Genetic Hotels of the Standard Genetic Code (SGC). We start by considering the primeval RNA genetic code which consists of the 16 codons of type RNY (purine-any base-pyrimidine). Using simple algebraic operations, we show how the RNA code could have evolved toward the current SGC via two different intermediate evolutionary stages called Extended RNA code type I and II. By rotations or translations of the subset RNY, we arrive at the SGC via the former (type I) or via the latter (type II), respectively. Biologically, the Extended RNA code type I, consists of all codons of the type RNY plus codons obtained by considering the RNA code but in the second (NYR type) and third (YRN type) reading frames. The Extended RNA code type II, comprises all codons of the type RNY plus codons that arise from transversions of the RNA code in the first (YNY type) and third (RNR) nucleotide bases. Since the dimensions of remarkable subsets of the Genetic Hotels are not necessarily integer numbers, we also introduce the concept of algebraic fractal dimension. A general decoding function which maps each codon to its corresponding amino acid or the stop signals is also derived. The Phenotypic Hotel of amino acids is also illustrated. The proposed evolutionary paths are discussed in terms of the existing theories of the evolution of the SGC. The adoption of 3-dimensional models of the Genetic and Phenotypic Hotels will facilitate the understanding of the biological properties of the SGC.

  3. Sanitary status and incidence of methicillin-resistant Staphylococcus aureus and Clostridium difficile within Canadian hotel rooms.

    PubMed

    Xu, Changyun; Weese, Scott J; Namvar, Azadeh; Warriner, Keith

    2015-04-01

    The study described in this article aimed at establishing a baseline assessment of the sanitary status of ice and guest rooms within Canadian hotels. Collectively, 54 hotel rooms belonging to six different national chains were sampled. High-contact surfaces (comforter, alarm clock, bedside lamp, TV remote, bathroom countertop, faucet, and toilet seat) were sampled using adenosine triphosphate (ATP) swabs and replicate organism detection and counting plates. ATP swab readings ranged from 2.12 to 4.42 log relative light units. Coliforms were recovered from 36% of surfaces with high prevalence being recovered from the comforter, TV remote, bathroom countertop, faucet, and toilet seat. Oxacillin-resistant bacteria were recovered from 19% of surfaces with 46% of isolates confirmed as methicillin-resistant Staphylococcus aureus. Two toxigenic Clostridium difficile isolates were recovered in the course of the study. Collectively, 24% of the ice samples harbored coliforms with a single sample testing positive for E. coli. The authors' study demonstrates that hotel rooms represent a potential source of community-acquired infections and the need for enhanced sanitation practices. PMID:25876260

  4. Widespread environmental contamination with Norwalk-like viruses (NLV) detected in a prolonged hotel outbreak of gastroenteritis.

    PubMed

    Cheesbrough, J S; Green, J; Gallimore, C I; Wright, P A; Brown, D W

    2000-08-01

    A protracted outbreak of Norwalk-like virus (NLV)-associated gastroenteritis occurred in a large hotel in North-West England between January and May 1996. We investigated the pattern of environmental contamination with NLV in the hotel during and after the outbreak. In the ninth week, 144 environmental swabs taken from around the hotel were tested for NLV by nested RT-PCR. The sites were categorized according to the likelihood of direct contamination with vomit/faeces. The highest proportion of positive samples were detected in directly contaminated carpets, but amplicons were detected in sites above 1.5 m which are unlikely to have been contaminated directly. The trend in positivity of different sites paralleled the diminishing likelihood of direct contamination. A second environmental investigation of the same sites 5 months after the outbreak had finished were all negative by RT-PCR. This study demonstrates for the first time the extent of environmental contamination that may occur during a large NLV outbreak.

  5. Statistical group differences in anatomical shape analysis using Hotelling T2 metric

    NASA Astrophysics Data System (ADS)

    Styner, Martin; Oguz, Ipek; Xu, Shun; Pantazis, Dimitrios; Gerig, Guido

    2007-03-01

    Shape analysis has become of increasing interest to the neuroimaging community due to its potential to precisely locate morphological changes between healthy and pathological structures. This manuscript presents a comprehensive set of tools for the computation of 3D structural statistical shape analysis. It has been applied in several studies on brain morphometry, but can potentially be employed in other 3D shape problems. Its main limitations is the necessity of spherical topology. The input of the proposed shape analysis is a set of binary segmentation of a single brain structure, such as the hippocampus or caudate. These segmentations are converted into a corresponding spherical harmonic description (SPHARM), which is then sampled into a triangulated surfaces (SPHARM-PDM). After alignment, differences between groups of surfaces are computed using the Hotelling T2 two sample metric. Statistical p-values, both raw and corrected for multiple comparisons, result in significance maps. Additional visualization of the group tests are provided via mean difference magnitude and vector maps, as well as maps of the group covariance information. The correction for multiple comparisons is performed via two separate methods that each have a distinct view of the problem. The first one aims to control the family-wise error rate (FWER) or false-positives via the extrema histogram of non-parametric permutations. The second method controls the false discovery rate and results in a less conservative estimate of the false-negatives. Prior versions of this shape analysis framework have been applied already to clinical studies on hippocampus and lateral ventricle shape in adult schizophrenics. The novelty of this submission is the use of the Hotelling T2 two-sample group difference metric for the computation of a template free statistical shape analysis. Template free group testing allowed this framework to become independent of any template choice, as well as it improved the

  6. Image-domain sampling properties of the Hotelling Observer in CT using filtered back-projection

    NASA Astrophysics Data System (ADS)

    Sanchez, Adrian A.; Sidky, Emil Y.; Pan, Xiaochuan

    2015-03-01

    The Hotelling Observer (HO),1 along with its channelized variants,2 has been proposed for image quality evaluation in x-ray CT.3,4 In this work, we investigate HO performance for a detection task in parallel-beam FBP as a function of two image-domain sampling parameters, namely pixel size and field-of-view. These two parameters are of central importance in adapting HO methods to use in CT, since the large number of pixels in a single image makes direct computation of HO performance for a full image infeasible in most cases. Reduction of the number of image pixels and/or restriction of the image to a region-of-interest (ROI) has the potential to make direct computation of HO statistics feasible in CT, provided that the signal and noise properties lead to redundant information in some regions of the image. For small signals, we hypothesize that reduction of image pixel size and enlargement of the image field-of-view are approximately equivalent means of gaining additional information relevant to a detection task. The rationale for this hypothesis is that the backprojection operation in FBP introduces long range correlations so that, for small signals, the reconstructed signal outside of a small ROI is not linearly independent of the signal within the ROI. In this work, we perform a preliminary investigation of this hypothesis by sweeping these two sampling parameters and computing HO performance for a signal detection task.

  7. Hydrologic data, 1974-77, Stovepipe Wells Hotel area, Death Valley National Monument, Inyo County, California

    USGS Publications Warehouse

    Lamb, Charles Edwin; Downing, D.J.

    1979-01-01

    Ground-water levels in most wells did not change significantly from 1974 to 1977 in the Stovepipe Wells Hotel area, California. The average water-level decline was less than 0.10 foot between August 1974 and August 1977 in 10 observation wells. Water-level contours show a depression centered on the two pumping wells, but this depression existed before the National Park Service started pumping its well. The chemical quality of the ground water is poor. Dissolved-solids concentrations in water samples ranged from 2,730 to 6,490 milligrams per liter. Analyses of water samples from two wells showed large changes in some constituents from 1976 to 1977. Streamflow in Salt Creek has been monitored since February 1974. Base flow is seasonal, being 0.10 to 0.20 cubic foot per second during the summer and as much as three times that amount during the winter. Two chemical analyses of water from Salt Creek, representing summer and winter flow conditions, show large differences for many constituents. (Woodard-USGS)

  8. A Waterborne Gastroenteritis Outbreak Caused by Norovirus GII.17 in a Hotel, Hebei, China, December 2014.

    PubMed

    Qin, Meng; Dong, Xiao-Gen; Jing, Yan-Yan; Wei, Xiu-Xia; Wang, Zhao-E; Feng, Hui-Ru; Yu, Hong; Li, Jin-Song; Li, Jie

    2016-09-01

    Norovirus (NoV) is responsible for an estimated 90 % of all epidemic nonbacterial outbreaks of gastroenteritis worldwide. Waterborne outbreaks of NoV are commonly reported. A novel GII.17 NoV strain emerged as a major cause of gastroenteritis outbreaks in China during the winter of 2014/2015. During this time, an outbreak of gastroenteritis occurred at a hotel in a ski park in Hebei Province, China. Epidemiological investigations indicated that one water well, which had only recently been in use, was the probable source. GII.17 NoV was detected by real-time reverse-transcription polymerase chain reaction from samples taken from cases, from concentrated water samples from water well, and from the nearby sewage settling tank. Nucleotide sequences of NoV extracted from clinical and water specimens were genetically identical and had 99 % homology with Beijing/CHN/2015. All epidemiological data indicated that GII.17 NoV was responsible for this outbreak. This is the first reported laboratory-confirmed waterborne outbreak caused by GII.17 NoV genotype in China. Strengthening management of well drinking water and systematica monitoring of NoV is essential for preventing future outbreaks. PMID:27084118

  9. Household, hotel and market waste audits for composting in Vietnam and Laos.

    PubMed

    Byer, Philip H; Hoang, Chi Phuong; Nguyen, Thi Thuc Thuy; Chopra, Sangeeta; Maclaren, Virginia; Haight, Murray

    2006-10-01

    In Da Nang and Ha Long, Vietnam and in Vientiane, Laos, there was interest by local authorities in separating and composting waste in order to reduce environmental and health problems at the local landfills and to produce a soil conditioner for local agricultural use. To assist in the planning of composting projects, three studies were carried out to estimate waste quantities and composition. 1. A 9-day audit of waste from 45 vendors in a market in Vientiane, the capital of Laos. The total quantity of waste and the quantity in each of nine categories were estimated for each of six different types of vendors. 2. A 7-day audit of waste disposed by three hotels in the tourist area of Ha Long, Vietnam. Waste quantities were estimated in total, on a per guest basis, and in three main categories: compostables, recyclables and miscellaneous. 3. A 7-day audit of waste collected from 74 households in Da Nang, the fourth largest city in Vietnam. Waste from each household was separated into compostable and non-compostable waste. Over 60% of each waste source comprised compostable waste and this was considered significant enough to warrant further planning of composting operations.

  10. Individual treatment of hotel and restaurant waste water in rural areas.

    PubMed

    Van Hulle, S W H; Ghyselbrecht, N; Vermeiren, T J L; Depuydt, V; Boeckaert, C

    2012-01-01

    About 25 hotels, restaurants and pubs in the rural community Heuvelland are situated in the area designated for individual water treatment. In order to meet the legislation by the end of 2015, each business needs to install an individual waste water treatment system (IWTS). To study this situation, three catering businesses were selected for further research. The aim of the study was to quantify the effluent quality and to assess IWTS performance for these catering businesses. First of all, the influence of discharging untreated waste water on the receiving surface water was examined. The results showed a decrease in water quality after the discharge point at every business. With the collected data, simulations with the software WEST were performed. With this software two types of IWTSs with different (buffer) volumes were modelled and tested for each catering business. The first type is a completely mixed activated sludge reactor and the second type is a submerged aerobic fixed-bed reactor. The results of these simulations demonstrate that purification with an IWTS is possible if the capacity is large enough and if an adequate buffer volume is installed and if regular maintenance is performed. PMID:22629640

  11. Performance evaluation of medical LCD displays using 3D channelized Hotelling observers

    NASA Astrophysics Data System (ADS)

    Platiša, Ljiljana; Marchessoux, Cédric; Goossens, Bart; Philips, Wilfried

    2011-03-01

    High performance of the radiologists in the task of image lesion detection is crucial for successful medical practice. One relevant factor in clinical image reading is the quality of the medical display. With the current trends of stack-mode liquid crystal displays (LCDs), the slow temporal response of the display plays a significant role in image quality assurance. In this paper, we report on the experimental study performed to evaluate the quality of a novel LCD with advanced temporal response compensation, and compare it to an existing state-of-the-art display of the same category but with no temporal response compensation. The data in the study comprise clinical digital tomosynthesis images of the breast with added simulated mass lesions. The detectability for the two displays is estimated using the recent multi-slice channelized Hotelling observer (msCHO) model which is especially designed for multi-slice image data. Our results suggest that the novel LCD allows higher detectability than the existing one. Moreover, the msCHO results are used to advise on the parameters for the follow up image reading study with real medical doctors as observers. Finally, the main findings of the msCHO study were confirmed by a human reader study (details to be published in a separate paper).

  12. Auroras Now! - Auroral nowcasting service for Hotels in Finnish Lapland and its performance during winter 2003-2004

    NASA Astrophysics Data System (ADS)

    Kauristie, K.; Mälkki, A.; Pulkkinen, A.; Nevanlinna, H.; Ketola, A.; Tulkki, V.; Raita, T.; Blanco, A.

    2004-12-01

    European Space Agency is currently supporting 17 Service Development Activities (SDA) within its Space Weather Pilot Project. Auroras Now!, one of the SDAs, has been operated during November 2003 - March 2004 as its pilot season. The service includes a public part freely accessible in Internet (http://aurora.fmi.fi) and a private part visible only to the customers of two hotels in the Finnish Lapland through the hotels' internal TV-systems. The nowcasting system is based on the magnetic recordings of two geophysical observatories, Sodankylä (SOD, MLAT ~64 N) and Nurmijärvi (NUR, MLAT ~57 N). The probability of auroral occurrence is continuously characterised with an empirically determined three-level scale. The index is updated once per hour and based on the magnetic field variations recorded at the observatories. During dark hours the near-real time auroral images acquired at SOD are displayed. The hotel service also includes cloudiness predictions for the coming night. During the pilot season the reliability of the three-level magnetic alarm system was weekly evaluated by comparing its prediction with auroral observations by the nearby all-sky camera. Successful hits and failures were scored according to predetermined rules. The highest credit points when it managed to spot auroras in a timely manner and predict their brightness correctly. Maximum penalty points were given when the alarm missed clear bright auroras lasting for more than one hour. In this presentation we analyse the results of the evaluation, present some ideas to further sharpen the procedure, and discuss more generally the correlation between local auroral and magnetic activity.

  13. Occurrence and parameters of frequency of Legionella in warm water systems of hospitals and hotels in Lower Saxony.

    PubMed

    Habicht, W; Müller, H E

    1988-03-01

    A total of 1241 water samples was investigated from 103 hospitals and 62 hotels in Lower Saxony 1985-87. 331 of 949 samples from hospitals and 26 of 292 samples from hotels were Legionella positive. All together 70% of the hospitals and 18% of the hotels investigated were Legionella positive, and 836 strains of Legionella were isolated (Table 1). As they could be diagnosed they belong to L. pneumophila SG1 306 strains, SG2 36 strains, SG3 127 strains, SG4 45 strain, SG5 29 strain, SG6 106 strains, SG9 13 strains and SG10 13 strains. Further 134 strains belonging to L. pneumophila but not to SG1-SG12 show cross reactions with serogroups 5, 8, and 10. Finally, 16 strains belong to L. dumoffii and 1 strain to L. anisa (Table 2). The following parameters of water samples were studied, too: temperature, pH value, conductivity, concentration of iron, of organic matter, of other bacteria, occurrence of amoebas, and the materials of water plumbing systems. Most samples contained concentrations of Legionella in the range of 10(1)-10(3) CFU/ml, highest concentrations were 10(5) CFU/ml (Fig. 1). Most frequently, Legionella were isolated within the range of temperature of 35-45 degrees C. However, a few of the water samples were positive for Legionella even up to 66 degrees C (Fig. 3). The conductivity has no and the pH value (Fig. 2) has only little influence on the occurrence of Legionella. There is a positive correlation between concentration of iron and frequency of Legionella (Fig. 4). Also organic matter (Fig. 6) and amoebas (Table 3) seem to enhance the occurrence of Legionella. Plumbing systems consisting of copper showed an inhibitory effect on Legionella during the first five years, whereas no effect could be detected in older systems (Fig. 5).

  14. The use of kernel local Fisher discriminant analysis for the channelization of the Hotelling model observer

    NASA Astrophysics Data System (ADS)

    Wen, Gezheng; Markey, Mia K.

    2015-03-01

    It is resource-intensive to conduct human studies for task-based assessment of medical image quality and system optimization. Thus, numerical model observers have been developed as a surrogate for human observers. The Hotelling observer (HO) is the optimal linear observer for signal-detection tasks, but the high dimensionality of imaging data results in a heavy computational burden. Channelization is often used to approximate the HO through a dimensionality reduction step, but how to produce channelized images without losing significant image information remains a key challenge. Kernel local Fisher discriminant analysis (KLFDA) uses kernel techniques to perform supervised dimensionality reduction, which finds an embedding transformation that maximizes betweenclass separability and preserves within-class local structure in the low-dimensional manifold. It is powerful for classification tasks, especially when the distribution of a class is multimodal. Such multimodality could be observed in many practical clinical tasks. For example, primary and metastatic lesions may both appear in medical imaging studies, but the distributions of their typical characteristics (e.g., size) may be very different. In this study, we propose to use KLFDA as a novel channelization method. The dimension of the embedded manifold (i.e., the result of KLFDA) is a counterpart to the number of channels in the state-of-art linear channelization. We present a simulation study to demonstrate the potential usefulness of KLFDA for building the channelized HOs (CHOs) and generating reliable decision statistics for clinical tasks. We show that the performance of the CHO with KLFDA channels is comparable to that of the benchmark CHOs.

  15. Diagnosis of Parkinsonian disorders using a channelized Hotelling observer model: Proof of principle

    SciTech Connect

    Bal, H.; Bal, G.; Acton, P. D.

    2007-10-15

    Imaging dopamine transporters using PET and SPECT probes is a powerful technique for the early diagnosis of Parkinsonian disorders. In order to perform automated accurate diagnosis of these diseases, a channelized Hotelling observer (CHO) based model was developed and evaluated using the SPECT tracer [Tc-99m]TRODAT-1. Computer simulations were performed using a digitized striatal phantom to characterize early stages of the disease (20 lesion-present cases with varying lesion size and contrast). Projection data, modeling the effects of attenuation and geometric response function, were obtained for each case. Statistical noise levels corresponding to those observed clinically were added to the projection data to obtain 100 noise realizations for each case. All the projection data were reconstructed, and a subset of the transaxial slices containing the striatum was summed and used for further analysis. CHO models, using the Laguerre-Gaussian functions as channels, were designed for two cases: (1) By training the model using individual lesion-present samples and (2) by training the model using pooled lesion-present samples. A decision threshold obtained for each CHO model was used to classify the study population (n=40). It was observed that individual lesion trained CHO models gave high diagnostic accuracy for lesions that were larger than those used to train the model and vice-versa. On the other hand, the pooled CHO model was found to give a high diagnostic accuracy for all the lesion cases (average diagnostic accuracy=0.95{+-}0.07; p<0.0001 Fisher's exact test). Based on our results, we conclude that a CHO model has the potential to provide early and accurate diagnosis of Parkinsonian disorders, thereby improving patient management.

  16. Academic medicine amenities unit: developing a model to integrate academic medical care with luxury hotel services.

    PubMed

    Kennedy, David W; Kagan, Sarah H; Abramson, Kelly Brennen; Boberick, Cheryl; Kaiser, Larry R

    2009-02-01

    The interface between established values of academic medicine and the trend toward inpatient amenities units requires close examination. Opinions of such units can be polarized, reflecting traditional reservations about the ethical dilemma of offering exclusive services only to an elite patient group. An amenities unit was developed at the University of Pennsylvania Health System in 2007, using an approach that integrated academic medicine values with the benefits of philanthropy and service excellence to make amenities unit services available to all patients. Given inherent internal political concerns, a broadly based steering committee of academic and hospital leadership was developed. An academically appropriate model was conceived, anchored by four principles: (1) integration of academic values, (2) interdisciplinary senior leadership, (3) service excellence, and (4) recalibrated occupancy expectations based on multiple revenue streams. Foremost is ensuring the same health care is afforded all patients throughout the hospital, thereby overcoming ethical challenges and optimizing teaching experiences. Service excellence frames the service ethic for all staff, and this, in addition to luxury hotel-style amenities, differentiates the style and feel of the unit from others in the hospital. Recalibrated occupancy creates program viability given revenue streams redefined to encompass gifts and patient revenue, including both reimbursement and self-pay. The medical-surgical amenities patient-care unit has enjoyed a successful first year and a growing stream of returning patients and admitting physicians. Implications for other academic medical centers include opportunities to extrapolate service excellence throughout the hospital and to cultivate philanthropy to benefit services throughout the medical center. PMID:19174661

  17. Academic medicine amenities unit: developing a model to integrate academic medical care with luxury hotel services.

    PubMed

    Kennedy, David W; Kagan, Sarah H; Abramson, Kelly Brennen; Boberick, Cheryl; Kaiser, Larry R

    2009-02-01

    The interface between established values of academic medicine and the trend toward inpatient amenities units requires close examination. Opinions of such units can be polarized, reflecting traditional reservations about the ethical dilemma of offering exclusive services only to an elite patient group. An amenities unit was developed at the University of Pennsylvania Health System in 2007, using an approach that integrated academic medicine values with the benefits of philanthropy and service excellence to make amenities unit services available to all patients. Given inherent internal political concerns, a broadly based steering committee of academic and hospital leadership was developed. An academically appropriate model was conceived, anchored by four principles: (1) integration of academic values, (2) interdisciplinary senior leadership, (3) service excellence, and (4) recalibrated occupancy expectations based on multiple revenue streams. Foremost is ensuring the same health care is afforded all patients throughout the hospital, thereby overcoming ethical challenges and optimizing teaching experiences. Service excellence frames the service ethic for all staff, and this, in addition to luxury hotel-style amenities, differentiates the style and feel of the unit from others in the hospital. Recalibrated occupancy creates program viability given revenue streams redefined to encompass gifts and patient revenue, including both reimbursement and self-pay. The medical-surgical amenities patient-care unit has enjoyed a successful first year and a growing stream of returning patients and admitting physicians. Implications for other academic medical centers include opportunities to extrapolate service excellence throughout the hospital and to cultivate philanthropy to benefit services throughout the medical center.

  18. Using channelized Hotelling observers to quantify temporal effects of medical liquid crystal displays on detection performance

    NASA Astrophysics Data System (ADS)

    Platiša, Ljiljana; Goossens, Bart; Vansteenkiste, Ewout; Badano, Aldo; Philips, Wilfried

    2010-02-01

    Clinical practice is rapidly moving in the direction of volumetric imaging. Often, radiologists interpret these images in liquid crystal displays at browsing rates of 30 frames per second or higher. However, recent studies suggest that the slow response of the display can compromise image quality. In order to quantify the temporal effect of medical displays on detection performance, we investigate two designs of a multi-slice channelized Hotelling observer (msCHO) model in the task of detecting a single-slice signal in multi-slice simulated images. The design of msCHO models is inspired by simplifying assumptions about how humans observe while viewing in the stack-browsing mode. For comparison, we consider a standard CHO applied only on the slice where the signal is located, recently used in a similar study. We refer to it as a single-slice CHO (ssCHO). Overall, our results confirm previous findings that the slow response of displays degrades the detection performance of the observers. More specifically, the observed performance range of msCHO designs is higher compared to the ssCHO suggesting that the extent and rate of degradation, though significant, may be less drastic than previously estimated by the ssCHO. Especially, the difference between msCHO and ssCHO is more significant for higher browsing speeds than for slow image sequences or static images. This, together with their design criteria driven by the assumptions about humans, makes the msCHO models promising candidates for further studies aimed at building anthropomorphic observer models for the stack-mode image presentation.

  19. Health-seeking behavior and social networks of the aged living in single-room occupancy hotels.

    PubMed

    Cohen, C I; Sokolovsky, J

    1979-06-01

    The elderly who reside in single-room occupancy (SRO) hotels often have been depicted as "isolates," lacking the interest or ability to engage primary or secondary support systems. This characterization has not enhanced understanding of how the SRO aged are able to survive in the community. With the use of network analysis techniques, this study demonstrates the inaccuracy of the assertion that these old persons lack significant social support. The data pointed to differences in network size, complexity, intensity, connectedness, and directionality in relation to varying degrees of physical and psychiatric health.

  20. The murderer is the bed: an unusual case of death by traumatic asphyxia in a hotel folding bunk bed.

    PubMed

    Domènech, Mercè Subirana; Alcázar, Helena Martínez; Pallarès, Antoni Aguilar; Vicente, Ignasi Galtés; García, Josep Castellà; Gutiérrez, Claudina Vidal; Muñiz, Jordi Medallo

    2012-07-10

    This paper presents the first referenced case on a death by traumatic asphyxia in a folding bunk bed. A middle-aged man was found dead in a hotel room trapped into a lower folding bunk bed where he had been sleeping after a party. The autopsy showed signs of asphyxia and excluded signs of struggle and sexual intercourse. Toxicological analyses revealed alcohol intoxication. A differential diagnosis of the manner of death including a technical study of the bed which contributed to understand the circumstances of death was made. The medico-legal investigation of the case strongly supported the hypothesis of an accidental death by traumatic asphyxia.

  1. Special report. Hospitals that are becoming 'hotel friendly' to guests ... and the role played by security officers.

    PubMed

    1996-01-01

    Faced with increasing competition, hospitals in New York City are developing programs to become more user friendly and, like hotels, to treat patients more as "guests" than as "customers." These programs, which have particular applications for security personnel, are also seeking to improve communications and relationships among the hospital's medical staff and other employees. In this report, we'll describe some of these efforts in which hospitals are turning to hoteliers, consultants, and others for advice in the area of customer service, and the role seen for hospital security. PMID:10154274

  2. Na+ coordination at the Na2 site of the Na+/I- symporter.

    PubMed

    Ferrandino, Giuseppe; Nicola, Juan Pablo; Sánchez, Yuly E; Echeverria, Ignacia; Liu, Yunlong; Amzel, L Mario; Carrasco, Nancy

    2016-09-13

    The sodium/iodide symporter (NIS) mediates active I(-) transport in the thyroid-the first step in thyroid hormone biosynthesis-with a 2 Na(+): 1 I(-) stoichiometry. The two Na(+) binding sites (Na1 and Na2) and the I(-) binding site interact allosterically: when Na(+) binds to a Na(+) site, the affinity of NIS for the other Na(+) and for I(-) increases significantly. In all Na(+)-dependent transporters with the same fold as NIS, the side chains of two residues, S353 and T354 (NIS numbering), were identified as the Na(+) ligands at Na2. To understand the cooperativity between the substrates, we investigated the coordination at the Na2 site. We determined that four other residues-S66, D191, Q194, and Q263-are also involved in Na(+) coordination at this site. Experiments in whole cells demonstrated that these four residues participate in transport by NIS: mutations at these positions result in proteins that, although expressed at the plasma membrane, transport little or no I(-) These residues are conserved throughout the entire SLC5 family, to which NIS belongs, suggesting that they serve a similar function in the other transporters. Our findings also suggest that the increase in affinity that each site displays when an ion binds to another site may result from changes in the dynamics of the transporter. These mechanistic insights deepen our understanding not only of NIS but also of other transporters, including many that, like NIS, are of great medical relevance.

  3. Microbiological levels of randomly selected food contact surfaces in hotels located in Spain during 2007-2009.

    PubMed

    Doménech-Sánchez, Antonio; Laso, Elena; Pérez, María José; Berrocal, Clara Isabel

    2011-09-01

    The aim of this study was to survey the microbial levels of food contact surfaces in hotels. Microbiological levels of 4611 surfaces (chopping machines, kitchenware, knives, worktops, and cutting boards) from 280 different facilities in Spain were determined in a 3-year period. The contact-plate technique was used throughout the survey. Overall, the mean of the log of total aerobic count cm(-2) was 0.62, better than those reported for child-care and assisted living facilities. Significant differences were detected among different types of surfaces, time of sampling, season, and year. The majority (74%) of food contact surfaces sampled in Spanish hotels was within the recommended standard of <1.3 log CFU cm(-2), and differences depend on several factors. Our results set a representative picture of the actual situation in our resorts and establish the basis for the development of educational programs to improve food handlers' knowledge of foodborne diseases and their transmission via food contact surfaces.

  4. Evaluation of increases in dissolved solids in ground water, Stovepipe Wells Hotel, Death Valley National Monument, California

    USGS Publications Warehouse

    Buono, Anthony; Packard, E.M.

    1982-01-01

    Increases in dissolved solids have been monitored in two observation wells near Stovepipe Wells Hotel, Death Valley National Monument, California. One of the hotel 's supply wells delivers water to a reverse-osmosis treatment plant that produces the area 's potable water supply. Should water with increased dissolved solids reach the supply well, the costs of production of potable water will increase. The reverse-osmosis plant supply well is located about 0.4 mile south of one of the wells where increases have been monitored, and 0.8 mile southwest of the well where the most significant increases have been monitored. The direction of local ground-water movement is eastward, which reduces the probability of the supply well being affected. Honey mesquite, a phreatophyte located about 1.5 miles downgradient from the well where the most significant increases have been monitored, might be adversely affected should water with increased dissolved solids extend that far. Available data and data collected during this investigation do not indicate the source of the dissolved-solids increases. Continued ground-water-quality monitoring of existing wells and the installation of additional wells for water-quality monitoring would be necessary before the area affected by the increases, and the source and direction of movement of the water with increased dissolved solids, can be determined. (USGS)

  5. Microbiological levels of randomly selected food contact surfaces in hotels located in Spain during 2007-2009.

    PubMed

    Doménech-Sánchez, Antonio; Laso, Elena; Pérez, María José; Berrocal, Clara Isabel

    2011-09-01

    The aim of this study was to survey the microbial levels of food contact surfaces in hotels. Microbiological levels of 4611 surfaces (chopping machines, kitchenware, knives, worktops, and cutting boards) from 280 different facilities in Spain were determined in a 3-year period. The contact-plate technique was used throughout the survey. Overall, the mean of the log of total aerobic count cm(-2) was 0.62, better than those reported for child-care and assisted living facilities. Significant differences were detected among different types of surfaces, time of sampling, season, and year. The majority (74%) of food contact surfaces sampled in Spanish hotels was within the recommended standard of <1.3 log CFU cm(-2), and differences depend on several factors. Our results set a representative picture of the actual situation in our resorts and establish the basis for the development of educational programs to improve food handlers' knowledge of foodborne diseases and their transmission via food contact surfaces. PMID:21561384

  6. The Hotelling Trace Criterion Used for System Optimization and Feature Enhancement in Nuclear Medicine

    NASA Astrophysics Data System (ADS)

    Fiete, Robert Dean

    The Hotelling trace criterion (HTC) is a measure of class separability used in pattern recognition to find a set of linear features that optimally separate two classes of objects. In this dissertation we use the HTC not as a figure of merit for features, but as a figure of merit for characterizing imaging systems and designing filters for feature enhancement in nuclear medicine. If the HTC is to be used to optimize systems, then it must correlate with human observer performance. In our first study, a set of images, created by overlapping ellipses, was used to simulate images of livers. Two classes were created, livers with and without tumors, with noise and blur added to each image to simulate nine different imaging systems. Using the ROC parameter d_ {rm a} as our measure, we found that the HTC has a correlation of 0.988 with the ability of humans to separate these two classes of objects. A second study was performed to demonstrate the use of the HTC for system optimization in a realistic task. For this study we used a mathematical model of normal and diseased livers and of the imaging system to generate a realistic set of liver images from nuclear medicine. A method of adaptive, nonlinear filtering which enhances the features that separate two sets of images has also been developed. The method uses the HTC to find the optimal linear feature operator for the Fourier moduli of the images, and uses this operator as a filter so that the features that separate the two classes of objects are enhanced. We demonstrate the use of this filtering method to enhance texture features in simulated liver images from nuclear medicine, after using a training set of images to obtain the filter. We also demonstrate how this method of filtering can be used to reconstruct an object from a single photon-starved image of it, when the object contains a repetitive feature. When power spectrums for real liver scans from nuclear medicine are calculated, we find that the three

  7. 41 CFR 301-74.14 - Are there any special requirements for sponsoring or funding a conference at a hotel, motel or...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 4 2013-07-01 2012-07-01 true Are there any special requirements for sponsoring or funding a conference at a hotel, motel or other place of public accommodation... Responsibilities § 301-74.14 Are there any special requirements for sponsoring or funding a conference at a...

  8. 41 CFR 301-74.14 - Are there any special requirements for sponsoring or funding a conference at a hotel, motel or...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 41 Public Contracts and Property Management 4 2012-07-01 2012-07-01 false Are there any special requirements for sponsoring or funding a conference at a hotel, motel or other place of public accommodation... Responsibilities § 301-74.14 Are there any special requirements for sponsoring or funding a conference at a...

  9. 41 CFR 301-74.9 - Are there any special requirements for sponsoring or funding a conference at a hotel, motel or...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 41 Public Contracts and Property Management 4 2014-07-01 2014-07-01 false Are there any special requirements for sponsoring or funding a conference at a hotel, motel or other place of public accommodation... Responsibilities § 301-74.9 Are there any special requirements for sponsoring or funding a conference at a...

  10. An Evaluation of Manpower Training Needs in the Hotel-Restaurant Industry on Kauai, 1968, with Recommendations on Programs, Sources of Students, Instructors, and Funds.

    ERIC Educational Resources Information Center

    Lloyd, Robert W.

    This report, requested and funded by a committee of community leaders, investigates the recruiting, training and employment of cooks, waitresses, maids, and small business managers needed on the island of Kauai through the year 1973. Projected increases in tourism and hotel construction indicate substantial need for well trained personnel. Courses…

  11. 41 CFR 301-74.14 - Are there any special requirements for sponsoring or funding a conference at a hotel, motel or...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false Are there any special requirements for sponsoring or funding a conference at a hotel, motel or other place of public accommodation... Responsibilities § 301-74.14 Are there any special requirements for sponsoring or funding a conference at a...

  12. Forecasting Training Needs in the Hotel, Catering and Tourism Sector: A Comparative Analysis of Results from Regional Studies in Three European Countries.

    ERIC Educational Resources Information Center

    Giffard, Andre; Guegnard, Christine; Strietska-Ilina, Olga

    2001-01-01

    A pilot study on the hotel, catering, and tourism sector was conducted in the Burgundy region of France, Northwest region of the Czech Republic, and Podravje region of Slovenia. Three main kinds of factors of change were brought out. The first, evoked in Slovenia and the Czech Republic, concerned the opening of borders. Typical trends were…

  13. Increasing Performance of the Two-Role Work Strategy: A Study of the International College Hotel and Training Center in Thailand

    ERIC Educational Resources Information Center

    Dhevabanchachai, Nate-tra; Wattanacharoensil, Walanchalee

    2013-01-01

    This research paper aims to identify the factors that will increase the performance and professionalism of the associates by using the study of the Salaya Pavilion Hotel Training Center (SPH) in Thailand as a case sample. In the study, staffs with two roles, called associates, were assessed for their job performance and motivation. Employing…

  14. 41 CFR 301-74.14 - Are there any special requirements for sponsoring or funding a conference at a hotel, motel or...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 41 Public Contracts and Property Management 4 2011-07-01 2011-07-01 false Are there any special requirements for sponsoring or funding a conference at a hotel, motel or other place of public accommodation... Responsibilities § 301-74.14 Are there any special requirements for sponsoring or funding a conference at a...

  15. [Preventive health control of U. S. emigrants at the beginning of 20th century on the example of hotel "Emigrants" in Rijeka].

    PubMed

    Rotim Malvić, Jasna

    2015-01-01

    Rijeka inscribed herself on the list of great European emigration ports like Hamburg, Bremen, Liverpool in the end of the year 1903 when a ship of the British Cunard Line established a travel line from Rijeka to New York. Up to the year 1914, 317639 passengers - emigrants travelled to America from the port of Rijeka. The large flow of people caused problems for the city, for that reason, already in 1906 did the Hungarian ministry of home affairs started the construction of a grandiose building intended for the emigrants. When it was opened in 1908 it was named Hotel Emigrants and had a capacity of 2500 guests. The name Hotel was given to him because of the highest construction and sanitary standards applied during his construction, but also because of comfort provided for the emigrants, large bright dormitories, living rooms, one big and spacious terrace and a number of smaller ones indicated more to a touristic hotel than to a house for emigrants. Health surveillance of emigrants was performed by Dr. David Friedman, Dr. Arturo Jellouscheg and Dr. Emil Tauffer. They were in charge in front of the Maritime Gubernia in Rijeka, the U.S. consulate in Rijeka and the Adria Maritime Society. Although the city authorities and the Hungarian authorities boasted of the hotel and the rigid medical control over immigrants which was done there, American authorities have still often returned some emigrants, at the expense of the company, after inspection at Ellis Island revealing that before landing some individuals are sick.

  16. US acculturation is associated with health behaviors and obesity, but not their change, with a hotel-based intervention among Asian-Pacific Islanders

    PubMed Central

    Novotny, Rachel; Chen, Chuhe; Williams, Andrew E; Albright, Cheryl L; Nigg, Claudio R; Oshiro, Caryn ES; Stevens, Victor J

    2012-01-01

    Background Immigration to the United States has been associated with obesity, yet the relationship of acculturation with obesity and energy balance (i.e., physical activity/dietary intake) in adults is a complex issue. Limited longitudinal data is available on immigrant Asians and Pacific Islanders. Design Analyses were conducted on baseline data and change data from baseline to 24 months in the hotel-based cluster-randomized Work, Weight and Wellness (3W) trial involving 15 control and 15 intervention hotels on the island of Oahu, Hawaii. Sample Participants were adult employees of predominantly Asian and Pacific Islander ancestry who were assessed one or more times over the course of 24 months. The full sample consisted of 4236 hotel workers (about 40% of hotel workforce) at baseline, 3502 hotel workers at year one and 2963 hotel workers at the 24-month follow up. 1115 hotel workers had at least two measurements, and were included in the analysis. Intervention The 3W intervention was designed to promote weight loss via motivation and support for increases in physical activity and increased access to and consumption of healthy low fat/low calorie foods. The measure of acculturation consisted of a score that was a compilation of a participant’s age when he or she immigrated to the US/Hawaii, country of birth, language spoken at home, and years of education. Statistical Analyses We used mixed effect regression models for cross-sectional baseline models and longitudinal multilevel regression analysis of change in diet and physical activity behaviors and obesity over time using a fixed intercept. Estimates of the intervention effect are expressed as an annual rate of change for all study outcomes. Results At baseline acculturation was positively associated with body mass index, physical activity level; and fruit, meat, and sweetened drink intake level. In analyses of change over 24-months, acculturation did not significantly influence change in dietary intake or

  17. Na Cauda do Cometa

    NASA Astrophysics Data System (ADS)

    Voelzke, M. R.

    2009-01-01

    Quando viam um cometa, os antigos gregos imaginavam uma estrela com uma vasta cabeleira. Não à toa, a palavra deriva do termo koma, que significa cabelo. Constituídos por fragmentos de gelo e gases, os cometas possuem um núcleo sólido, que pode ter vários quilômetros de diâmetro, e uma cauda que sempre aponta na direção contrária ao Sol, devido aos ventos solares. Graças à aparência de pontos luminosos em movimento (ao contrário de outros astros, que parecem estáticos), esses corpos celestes foram interpretados por diferentes povos com muito misticismo, inspirando mitos tanto de boas-novas como de maus presságios. Conheça algumas dessas histórias:

  18. Regulation of the epithelial Na(+) channel by intracellular Na(+).

    PubMed

    Awayda, M S

    1999-08-01

    The hypothesis that the intracellular Na(+) concentration ([Na(+)](i)) is a regulator of the epithelial Na(+) channel (ENaC) was tested with the Xenopus oocyte expression system by utilizing a dual-electrode voltage clamp. [Na(+)](i) averaged 48.1 +/- 2.2 meq (n = 27) and was estimated from the amiloride-sensitive reversal potential. [Na(+)](i) was increased by direct injection of 27.6 nl of 0.25 or 0.5 M Na(2)SO(4). Within minutes of injection, [Na(+)](i) stabilized and remained elevated at 97.8 +/- 6.5 meq (n = 9) and 64. 9 +/- 4.4 (n = 5) meq 30 min after the initial injection of 0.5 and 0.25 M Na(2)SO(4), respectively. This increase of [Na(+)](i) caused a biphasic inhibition of ENaC currents. In oocytes injected with 0.5 M Na(2)SO(4) (n = 9), a rapid decrease of inward amiloride-sensitive slope conductance (g(Na)) to 0.681 +/- 0.030 of control within the first 3 min and a secondary, slower decrease to 0.304 +/- 0.043 of control at 30 min were observed. Similar but smaller inhibitions were also observed with the injection of 0.25 M Na(2)SO(4). Injection of isotonic K(2)SO(4) (70 mM) or isotonic K(2)SO(4) made hypertonic with sucrose (70 mM K(2)SO(4)-1.2 M sucrose) was without effect. Injection of a 0.5 M concentration of either K(2)SO(4), N-methyl-D-glucamine (NMDG) sulfate, or 0.75 M NMDG gluconate resulted in a much smaller initial inhibition (<14%) and little or no secondary decrease. Thus increases of [Na(+)](i) have multiple specific inhibitory effects on ENaC that can be temporally separated into a rapid phase that was complete within 2-3 min and a delayed slow phase that was observed between 5 and 30 min. PMID:10444397

  19. Bar code hotel: diverse interactions of semi-autonomous entities under the partial control of multiple operators

    NASA Astrophysics Data System (ADS)

    Hoberman, Perry

    1995-03-01

    In this paper I describe an interactive installation that was produced in 1994 as one of eight Art and Virtual Environments projects sponsored by the Banff Center for the Arts. The installation, Bar Code Hotel, makes use of a number of strategies to create a casual, social, multi-person interface. Among the goals was to investigate methods that would minimize any significant learning curve, allowing visitors to immediately interact with a virtual world in a meaningful way. By populating this virtual world with semi-independent entities that could be directed by participants even as these entities were interacting with each other, a rich and heterogeneous experience was produced in which a variety of relationships between human participants and virtual objects could be examined. The paper will describe some of the challenges of simultaneously processing multiple input sources affecting a virtual environment in which each object already has its own ongoing behavior.

  20. Economic design of Hotelling's T2 control chart on the presence of fixed sampling rate and exponentially assignable causes

    NASA Astrophysics Data System (ADS)

    Bahiraee, Ehsan; Raissi, Sadigh

    2014-07-01

    Control charts are extensively used in manufacturing contexts to monitor production processes. This article illustrates economical design of a variable sample size and control limit Hotelling's T 2 control chart based on a novel cost model when occurrence times of the assignable causes are exponentially distributed. The proposed nonlinear cost model is an extension of Duncan's (J Am Stat Assoc 51: 228-242, 1956) model which was employed for univariate cases. Applying genetic algorithm to find optimum parameter values and using an L 33 orthogonal array in sensitivity analysis on the model parameters is investigated through a numerical example to illustrate the effectiveness of the proposed approach.

  1. An Engineering and Cost Model For Human Space Settlement Architectures: Focus on Space Hotels and Moon/Mars Exploration

    NASA Astrophysics Data System (ADS)

    Reynerson, C. M.

    2000-01-01

    This paper addresses a concept-level model that produces technical design parameters and economic feasibility information addressing future inhabited Earth-orbiting and Moon/Mars Exploration platforms. In this context, the Mars exploration platforms considered include those currently chosen in the NASA Mars Design Reference Mission. Space hotels will also be examined. This paper uses a design methodology and analytical tools to create feasible concept design information for these space platforms. The design tool has been validated against a number of actual facility designs, and appropriate modal variables are adjusted to ensure that statistical approximations are valid for subsequent analyses. The tool is then employed in the examination of the impact of various payloads on the power, size (volume), and mass of the platform prone.A

  2. Solidification of NaCl-NaF eutectic in space

    NASA Technical Reports Server (NTRS)

    Yue, A. S.; Yu, J. G.

    1974-01-01

    Continuous and discontinuous NaF fibers, embedded in a NaCl matrix, have been produced in space and on earth, respectively. The production of continuous fibers in a eutectic mixture was attributed to the absence of convection current in the liquid during solidification in space. Image transmission and optical transmittance measurements of transverse sections of the space-grown and earth-grown ingots were made with a light microscope and a spectrometer. It was found that better optical properties were obtained from samples grown in space. This was attributed to a better alignment of NaF fibers along the ingot axis.

  3. Optical properties of NaCl-NaF eutectics

    NASA Technical Reports Server (NTRS)

    Yue, A. S.; Yu, J. G.

    1976-01-01

    A new concept is advanced to explain the phenomenon of transmittance versus far-field infrared wavelength of the directionally solidified NaCl-NaF eutectic in terms of the two-dimensional Bragg Scattering and the polarization effect of Rayleigh scattering. This concept can be applied to other eutectic systems as long as the index of refraction of the matrix over a range of wavelength is known. Experimental data are in excellent agreement with the theoretical prediction.

  4. Na+ recirculation and isosmotic transport.

    PubMed

    Larsen, E H; Møbjerg, N

    2006-01-01

    The Na(+) recirculation theory for solute-coupled fluid absorption is an expansion of the local osmosis concept introduced by Curran and analyzed by Diamond & Bossert. Based on studies on small intestine the theory assumes that the observed recirculation of Na(+) serves regulation of the osmolarity of the absorbate. Mathematical modeling reproducing bioelectric and hydrosmotic properties of small intestine and proximal tubule, respectively, predicts a significant range of observations such as isosmotic transport, hyposmotic transport, solvent drag, anomalous solvent drag, the residual hydraulic permeability in proximal tubule of AQP1 (-/-) mice, and the inverse relationship between hydraulic permeability and the concentration difference needed to reverse transepithelial water flow. The model reproduces the volume responses of cells and lateral intercellular space (lis) following replacement of luminal NaCl by sucrose as well as the linear dependence of volume absorption on luminal NaCl concentration. Analysis of solvent drag on Na(+) in tight junctions provides explanation for the surprisingly high metabolic efficiency of Na(+) reabsorption. The model predicts and explains low metabolic efficiency in diluted external baths. Hyperosmolarity of lis is governed by the hydraulic permeability of the apical plasma membrane and tight junction with 6-7 mOsm in small intestine and < or = 1 mOsm in proximal tubule. Truly isosmotic transport demands a Na(+) recirculation of 50-70% in small intestine but might be barely measurable in proximal tubule. The model fails to reproduce a certain type of observations: The reduced volume absorption at transepithelial osmotic equilibrium in AQP1 knockout mice, and the stimulated water absorption by gallbladder in diluted external solutions. Thus, it indicates cellular regulation of apical Na(+) uptake, which is not included in the mathematical treatment. PMID:17206513

  5. Na+ recirculation and isosmotic transport.

    PubMed

    Larsen, E H; Møbjerg, N

    2006-01-01

    The Na(+) recirculation theory for solute-coupled fluid absorption is an expansion of the local osmosis concept introduced by Curran and analyzed by Diamond & Bossert. Based on studies on small intestine the theory assumes that the observed recirculation of Na(+) serves regulation of the osmolarity of the absorbate. Mathematical modeling reproducing bioelectric and hydrosmotic properties of small intestine and proximal tubule, respectively, predicts a significant range of observations such as isosmotic transport, hyposmotic transport, solvent drag, anomalous solvent drag, the residual hydraulic permeability in proximal tubule of AQP1 (-/-) mice, and the inverse relationship between hydraulic permeability and the concentration difference needed to reverse transepithelial water flow. The model reproduces the volume responses of cells and lateral intercellular space (lis) following replacement of luminal NaCl by sucrose as well as the linear dependence of volume absorption on luminal NaCl concentration. Analysis of solvent drag on Na(+) in tight junctions provides explanation for the surprisingly high metabolic efficiency of Na(+) reabsorption. The model predicts and explains low metabolic efficiency in diluted external baths. Hyperosmolarity of lis is governed by the hydraulic permeability of the apical plasma membrane and tight junction with 6-7 mOsm in small intestine and < or = 1 mOsm in proximal tubule. Truly isosmotic transport demands a Na(+) recirculation of 50-70% in small intestine but might be barely measurable in proximal tubule. The model fails to reproduce a certain type of observations: The reduced volume absorption at transepithelial osmotic equilibrium in AQP1 knockout mice, and the stimulated water absorption by gallbladder in diluted external solutions. Thus, it indicates cellular regulation of apical Na(+) uptake, which is not included in the mathematical treatment.

  6. Contribution of (222)Rn-bearing water to indoor radon and indoor air quality assessment in hot spring hotels of Guangdong, China.

    PubMed

    Song, Gang; Wang, Xinming; Chen, Diyun; Chen, Yongheng

    2011-04-01

    This study investigates the contribution of radon ((222)Rn)-bearing water to indoor (222)Rn in thermal baths. The (222)Rn concentrations in air were monitored in the bathroom and the bedroom. Particulate matter (PM, both PM(10) and PM(2.5)) and carbon dioxide (CO(2)) were also monitored with portable analyzers. The bathrooms were supplied with hot spring water containing 66-260 kBq m(-3) of (222)Rn. The results show that the spray of hot spring water from the bath spouts is the dominant mechanism by which (222)Rn is released into the air of the bathroom, and then it diffuses into the bedroom. Average (222)Rn level was 110-410% higher in the bedrooms and 510-1200% higher in the bathrooms compared to the corresponding average levels when there was no use of hot spring water. The indoor (222)Rn levels were influenced by the (222)Rn concentrations in the hot spring water and the bathing times. The average (222)Rn transfer coefficients from water to air were 6.2 × 10(-4)-4.1 × 10(-3). The 24-h average levels of CO(2) and PM(10) in the hotel rooms were 89% and 22% higher than the present Indoor Air Quality (IAQ) standard of China. The main particle pollutant in the hotel rooms was PM(2.5). Radon and PM(10) levels in some hotel rooms were at much higher concentrations than guideline levels, and thus the potential health risks to tourists and especially to the hotel workers should be of great concern, and measures should be taken to lower inhalation exposure to these air pollutants.

  7. Direct estimation and correction of bias from temporally variable non-stationary noise in a channelized Hotelling model observer

    NASA Astrophysics Data System (ADS)

    Fetterly, Kenneth A.; Favazza, Christopher P.

    2016-08-01

    Channelized Hotelling model observer (CHO) methods were developed to assess performance of an x-ray angiography system. The analytical methods included correction for known bias error due to finite sampling. Detectability indices ({{d}\\prime} ) corresponding to disk-shaped objects with diameters in the range 0.5–4 mm were calculated. Application of the CHO for variable detector target dose (DTD) in the range 6–240 nGy frame‑1 resulted in {{d}\\prime} estimates which were as much as 2.9×  greater than expected of a quantum limited system. Over-estimation of {{d}\\prime}<∼ 3.0 was presumed to be a result of bias error due to temporally variable non-stationary noise. Statistical theory which allows for independent contributions of ‘signal’ from a test object (o) and temporally variable non-stationary noise (ns) was developed. The theory demonstrates that the biased dβ\\prime is the sum of the detectability indices associated with the test object ≤ft(d\\text{o}\\prime\\right) and non-stationary noise (d\\text{ns}\\prime ). Given the nature of the imaging system and the experimental methods, d\\text{o}\\prime cannot be directly determined independent of d\\text{ns}\\prime . However, methods to estimate d\\text{ns}\\prime independent of d\\text{o}\\prime were developed. In accordance with the theory, d\\text{ns}\\prime was subtracted from experimental estimates of dβ\\prime , providing an unbiased estimate of d\\text{o}\\prime . Estimates of d\\text{o}\\prime exhibited trends consistent with expectations of an angiography system that is quantum limited for high DTD and compromised by detector electronic readout noise for low DTD conditions. Results suggest that these methods provide d\\text{o}\\prime estimates which are accurate and precise for d\\text{o}\\prime~≥slant ∼ 1.0 . Further, results demonstrated that the source of bias was detector electronic readout noise. In summary, this work presents theory and methods to test for the presence

  8. Combining a wavelet transform with a channelized Hotelling observer for tumor detection in 3D PET oncology imaging

    NASA Astrophysics Data System (ADS)

    Lartizien, Carole; Tomei, Sandrine; Maxim, Voichita; Odet, Christophe

    2007-03-01

    This study evaluates new observer models for 3D whole-body Positron Emission Tomography (PET) imaging based on a wavelet sub-band decomposition and compares them with the classical constant-Q CHO model. Our final goal is to develop an original method that performs guided detection of abnormal activity foci in PET oncology imaging based on these new observer models. This computer-aided diagnostic method would highly benefit to clinicians for diagnostic purpose and to biologists for massive screening of rodents populations in molecular imaging. Method: We have previously shown good correlation of the channelized Hotelling observer (CHO) using a constant-Q model with human observer performance for 3D PET oncology imaging. We propose an alternate method based on combining a CHO observer with a wavelet sub-band decomposition of the image and we compare it to the standard CHO implementation. This method performs an undecimated transform using a biorthogonal B-spline 4/4 wavelet basis to extract the features set for input to the Hotelling observer. This work is based on simulated 3D PET images of an extended MCAT phantom with randomly located lesions. We compare three evaluation criteria: classification performance using the signal-to-noise ratio (SNR), computation efficiency and visual quality of the derived 3D maps of the decision variable λ. The SNR is estimated on a series of test images for a variable number of training images for both observers. Results: Results show that the maximum SNR is higher with the constant-Q CHO observer, especially for targets located in the liver, and that it is reached with a smaller number of training images. However, preliminary analysis indicates that the visual quality of the 3D maps of the decision variable λ is higher with the wavelet-based CHO and the computation time to derive a 3D λ-map is about 350 times shorter than for the standard CHO. This suggests that the wavelet-CHO observer is a good candidate for use in our guided

  9. Direct estimation and correction of bias from temporally variable non-stationary noise in a channelized Hotelling model observer

    NASA Astrophysics Data System (ADS)

    Fetterly, Kenneth A.; Favazza, Christopher P.

    2016-08-01

    Channelized Hotelling model observer (CHO) methods were developed to assess performance of an x-ray angiography system. The analytical methods included correction for known bias error due to finite sampling. Detectability indices ({{d}\\prime} ) corresponding to disk-shaped objects with diameters in the range 0.5-4 mm were calculated. Application of the CHO for variable detector target dose (DTD) in the range 6-240 nGy frame-1 resulted in {{d}\\prime} estimates which were as much as 2.9×  greater than expected of a quantum limited system. Over-estimation of {{d}\\prime}<˜ 3.0 was presumed to be a result of bias error due to temporally variable non-stationary noise. Statistical theory which allows for independent contributions of ‘signal’ from a test object (o) and temporally variable non-stationary noise (ns) was developed. The theory demonstrates that the biased dβ\\prime is the sum of the detectability indices associated with the test object ≤ft(d\\text{o}\\prime\\right) and non-stationary noise (d\\text{ns}\\prime ). Given the nature of the imaging system and the experimental methods, d\\text{o}\\prime cannot be directly determined independent of d\\text{ns}\\prime . However, methods to estimate d\\text{ns}\\prime independent of d\\text{o}\\prime were developed. In accordance with the theory, d\\text{ns}\\prime was subtracted from experimental estimates of dβ\\prime , providing an unbiased estimate of d\\text{o}\\prime . Estimates of d\\text{o}\\prime exhibited trends consistent with expectations of an angiography system that is quantum limited for high DTD and compromised by detector electronic readout noise for low DTD conditions. Results suggest that these methods provide d\\text{o}\\prime estimates which are accurate and precise for d\\text{o}\\prime~≥slant ˜ 1.0 . Further, results demonstrated that the source of bias was detector electronic readout noise. In summary, this work presents theory and methods to test for the presence of bias

  10. Direct estimation and correction of bias from temporally variable non-stationary noise in a channelized Hotelling model observer.

    PubMed

    Fetterly, Kenneth A; Favazza, Christopher P

    2016-08-01

    Channelized Hotelling model observer (CHO) methods were developed to assess performance of an x-ray angiography system. The analytical methods included correction for known bias error due to finite sampling. Detectability indices ([Formula: see text]) corresponding to disk-shaped objects with diameters in the range 0.5-4 mm were calculated. Application of the CHO for variable detector target dose (DTD) in the range 6-240 nGy frame(-1) resulted in [Formula: see text] estimates which were as much as 2.9×  greater than expected of a quantum limited system. Over-estimation of [Formula: see text] was presumed to be a result of bias error due to temporally variable non-stationary noise. Statistical theory which allows for independent contributions of 'signal' from a test object (o) and temporally variable non-stationary noise (ns) was developed. The theory demonstrates that the biased [Formula: see text] is the sum of the detectability indices associated with the test object [Formula: see text] and non-stationary noise ([Formula: see text]). Given the nature of the imaging system and the experimental methods, [Formula: see text] cannot be directly determined independent of [Formula: see text]. However, methods to estimate [Formula: see text] independent of [Formula: see text] were developed. In accordance with the theory, [Formula: see text] was subtracted from experimental estimates of [Formula: see text], providing an unbiased estimate of [Formula: see text]. Estimates of [Formula: see text] exhibited trends consistent with expectations of an angiography system that is quantum limited for high DTD and compromised by detector electronic readout noise for low DTD conditions. Results suggest that these methods provide [Formula: see text] estimates which are accurate and precise for [Formula: see text]. Further, results demonstrated that the source of bias was detector electronic readout noise. In summary, this work presents theory and methods to test for the

  11. Drugs preventing Na+ and Ca2+ overload.

    PubMed

    Ravens, U; Himmel, H M

    1999-03-01

    Cardiac intracellular Na+and Ca2+homeostasis is regulated by the concerted action of ion channels, pumps and exchangers. The Na+, K+-ATPase produces the electrochemical concentration gradient for Na+, which is the driving force for Ca2+removal from the cytosol via the Na+/Ca2+exchange. Reduction of this gradient by increased intracellular Na+concentration leads to cellular Ca2+overload resulting in arrhythmias and contractile dysfunction. Na+and Ca2+overload-associated arrhythmias can be produced experimentally by inhibition of Na+efflux (digitalis-induced intoxication) and by abnormal Na+influx via modulated Na+channels (veratridine, DPI 201-106; hypoxia) or via the Na+, H+exchanger. Theoretically, blockers of Na+and Ca2+channels, inhibitors of abnormal oscillatory release of Ca2+from internal stores or modulators of the Na+, Ca2+and Na+, H+exchanger activities could protect against cellular Na+and Ca2+overload. Three exemplary drugs that prevent Na+and Ca2+overload, i.e. the benzothiazolamine R56865, the methylenephenoxydioxy-derivative CP-060S, and the benzoyl-guanidine Hoe 642, a Na+, H+exchange blocker, are briefly reviewed with respect to their efficacy on digitalis-, veratridine- and ischaemia/reperfusion-induced arrhythmias. PMID:10094840

  12. Na Deposition on MnO(100)

    NASA Astrophysics Data System (ADS)

    Feng, Xu; Cox, David F.

    2016-03-01

    Na deposition on the MnO(100) surface was investigated by temperature programmed desorption (TPD), X-ray photoelectron spectroscopy (XPS) and low energy electron diffraction (LEED). Na TPD and XPS results indicate that adsorbed Na interacts strongly with the MnO substrate to form an irreversibly-adsorbed, oxidic Na compound on the surface for coverages up to 1 monolayer (ML). This strongly-bound Na diffuses into the MnO subsurface and bulk at elevated temperatures above 500 K. For Na coverages above 1 ML, metallic Na is present and desorbs from the surface below 500 K. The deposition of Na on MnO(100) follows a Stranski-Krastanov (SK) growth mode, with the formation of metallic Na islands following completion of the first Na monolayer. After Na deposition, the surface exhibits a diffuse (1 × 1) LEED pattern, suggesting the formation of disordered Na overlayers. After heating to 1000 K, the surface presents a (2 × 2) LEED pattern indicating that a surface reconstruction is induced by the diffusion of Na into the near surface region. CO2 can be used as a probe molecule in TPD to distinguish between metallic Na islands and oxidic Na in the first ML, and to indicate when Na that is still observable by XPS goes subsurface.

  13. A Multi-Period Optimization Model for Service Providers Using Online Reservation Systems: An Application to Hotels.

    PubMed

    Xu, Ming; Jiao, Yan; Li, Xiaoming; Cao, Qingfeng; Wang, Xiaoyang

    2015-01-01

    This paper presents a multi-period optimization model for high margin and zero salvage products in online distribution channels with classifying customers based on number of products required. Taking hotel customers as an example, one is regular customers who reserve rooms for one day, and the other is long term stay (LTS) customers who reserve rooms for a number of days. LTS may guarantee a specific amount of demand and generate opportunity income for a certain number of periods, meanwhile with risk of punishment incurred by overselling. By developing an operational optimization model and exploring the effects of parameters on optimal decisions, we suggest that service providers should make decisions based on the types of customers, number of products required, and duration of multi-period to reduce the loss of reputation and obtain more profit; at the same time, multi-period buying customers should buy products early. Finally, the paper conducts a numerical experiment, and the results are consistent with prevailing situations.

  14. Evaluation of six channelized Hotelling observers in combination with a contrast sensitivity function to predict human observer performance

    NASA Astrophysics Data System (ADS)

    Goffi, Marco; Veldkamp, Wouter J. H.; van Engen, Ruben E.; Bouwman, Ramona W.

    2015-03-01

    Standard methods to quantify image quality (IQ) may not be adequate for clinical images since they depend on uniform backgrounds and linearity. Statistical model observers are not restricted to these limitations and might be suitable for IQ evaluation of clinical images. One of these statistical model observers is the channelized Hotelling observer (CHO), where the images are filtered by a set of channels. The aim of this study was to evaluate six different channel sets, with an additional filter to simulate the human contrast sensitivity function (CSF), in their ability to predict human observer performance. For this evaluation a two alternative forced choice experiment was performed with two types of background structures (white noise (WN) and clustered lumpy background (CLB)), 5 disk-shaped objects with different diameters and 3 different signal energies. The results show that the correlation between human and model observers have a diameter dependency for some channel sets in combination with CLBs. The addition of the CSF reduces this diameter dependency and in some cases improves the correlation coefficient between human- and model observer. For the CLB the Partial Least Squares channel set shows the highest correlation with the human observer (r2=0.71) and for WN backgrounds it was the Gabor-channel set with CSF (r2=0.72). This study showed that for some channels there is a high correlation between human and model observer, which suggests that the CHO has potential as a tool for IQ analysis of digital mammography systems.

  15. Delineation and hydrologic effects of a gasoline leak at Stovepipe Wells Hotel, Death Valley National Monument, California

    USGS Publications Warehouse

    Buono, A.; Packard, Elaine M.

    1982-01-01

    Ground water is the only local source of water available to the Stovepipe Wells Hotel facilities of the Death Valley National Monument, California. A leak in a service station storage tank caused the formation of a gasoline layer overlying the water table, creating the potential for contamination of the water supply. The maximum horizontal extent of the gasoline layer was mathematically estimated to be 1,300 feet downgradient from the leaky gasoline tank. Exploratory drilling detected the gasoline layer between 900 and 1,400 feet downgradient and between 50 and 150 feet upgradient from the source. Traces of the soluble components of gasoline were also found in the aquifer 150 feet upgradient, and 250 feet distant from the source perpendicular to the direction of ground-water movement. The gasoline spill is not likely to have an effect on the supply wells located 0.4 mile south of the leak source, which is nearly perpendicular to the direction of ground-water movement and the primary direction of gasoline movement in the area. No effect on phreatophytes 2 miles downgradient from the layer is likely, but the potential effects of gasoline vapors within the unsaturated zone on local xerophytes are not known. (USGS)

  16. A Multi-Period Optimization Model for Service Providers Using Online Reservation Systems: An Application to Hotels

    PubMed Central

    Xu, Ming; Jiao, Yan; Li, Xiaoming; Cao, Qingfeng; Wang, Xiaoyang

    2015-01-01

    This paper presents a multi-period optimization model for high margin and zero salvage products in online distribution channels with classifying customers based on number of products required. Taking hotel customers as an example, one is regular customers who reserve rooms for one day, and the other is long term stay (LTS) customers who reserve rooms for a number of days. LTS may guarantee a specific amount of demand and generate opportunity income for a certain number of periods, meanwhile with risk of punishment incurred by overselling. By developing an operational optimization model and exploring the effects of parameters on optimal decisions, we suggest that service providers should make decisions based on the types of customers, number of products required, and duration of multi-period to reduce the loss of reputation and obtain more profit; at the same time, multi-period buying customers should buy products early. Finally, the paper conducts a numerical experiment, and the results are consistent with prevailing situations. PMID:26147663

  17. A Multi-Period Optimization Model for Service Providers Using Online Reservation Systems: An Application to Hotels.

    PubMed

    Xu, Ming; Jiao, Yan; Li, Xiaoming; Cao, Qingfeng; Wang, Xiaoyang

    2015-01-01

    This paper presents a multi-period optimization model for high margin and zero salvage products in online distribution channels with classifying customers based on number of products required. Taking hotel customers as an example, one is regular customers who reserve rooms for one day, and the other is long term stay (LTS) customers who reserve rooms for a number of days. LTS may guarantee a specific amount of demand and generate opportunity income for a certain number of periods, meanwhile with risk of punishment incurred by overselling. By developing an operational optimization model and exploring the effects of parameters on optimal decisions, we suggest that service providers should make decisions based on the types of customers, number of products required, and duration of multi-period to reduce the loss of reputation and obtain more profit; at the same time, multi-period buying customers should buy products early. Finally, the paper conducts a numerical experiment, and the results are consistent with prevailing situations. PMID:26147663

  18. β decay of Na32

    NASA Astrophysics Data System (ADS)

    Mattoon, C. M.; Sarazin, F.; Hackman, G.; Cunningham, E. S.; Austin, R. A. E.; Ball, G. C.; Chakrawarthy, R. S.; Finlay, P.; Garrett, P. E.; Grinyer, G. F.; Hyland, B.; Koopmans, K. A.; Leslie, J. R.; Phillips, A. A.; Schumaker, M. A.; Scraggs, H. C.; Schwarzenberg, J.; Smith, M. B.; Svensson, C. E.; Waddington, J. C.; Walker, P. M.; Washbrook, B.; Zganjar, E.

    2007-01-01

    The β-decay of Na32 has been studied using β-γ coincidences. New transitions and levels are tentatively placed in the level scheme of Mg32 from an analysis of γ-γ and β-γ-γ coincidences. The observation of the indirect feeding of the 2321 keV state in Mg32 removes some restrictions previously placed on the spin assignment for this state. No evidence of a state at 2117 keV in Mg32 is found. Previously unobserved weak transitions up to 5.4 MeV were recorded but could not be placed in the decay scheme of Na32.

  19. Interactions of external and internal H+ and Na+ with Na+/Na+ and Na+/H+ exchange of rabbit red cells: evidence for a common pathway.

    PubMed

    Morgan, K; Canessa, M

    1990-12-01

    We have studied the kinetic properties of rabbit red cell (RRBC) Na+/Na+ and Na+/H+ exchanges (EXC) in order to define whether or not both transport functions are conducted by the same molecule. The strategy has been to determine the interactions of Na+ and H+ at the internal (i) and external (o) sites for both exchanges modes. RRBC containing varying Nai and Hi were prepared by nystatin and DIDS treatment of acid-loaded cells. Na+/Na+ EXC was measured as Nao-stimulated Na+ efflux and Na+/H+ EXC as Nao-stimulated H+ efflux and delta pHo-stimulated Na+ influx into acid-loaded cells. The activation of Na+/Na+ EXC by Nao at pHi 7.4 did not follow simple hyperbolic kinetics. Testing of different kinetic models to obtain the best fit for the experimental data indicated the presence of high (Km 2.2 mM) and low affinity (Km 108 mM) sites for a single- or two-carrier system. The activation of Na+/H+ EXC by Nao (pHi 6.6, Nai less than 1 mM) also showed high (Km 11 mM) and low (Km 248 mM) affinity sites. External H+ competitively inhibited Na+/Na+ EXC at the low affinity Nao site (KH 52 nM) while internally H+ were competitive inhibitors (pK 6.7) at low Nai and allosteric activators (pK 7.0) at high Nai. Na+/H+ EXC was also inhibited by acid pHo and allosterically activated by Hi (pK 6.4). We also established the presence of a Nai regulatory site which activates Na+/H+ and Na+/Na+ EXC modifying the affinity for Nao of both pathways. At low Nai, Na+/Na+ EXC was inhibited by acid pHi and Na+/H+ stimulated but at high Nai, Na+/Na+ EXC was stimulated and Na+/H+ inhibited being the sum of both pathways kept constant. Both exchange modes were activated by two classes of Nao sites, cis-inhibited by external Ho, allosterically modified by the binding of H+ to a Hi regulatory site and regulated by Nai. These findings are consistent with Na+/Na+ EXC being a mode of operation of the Na+/H+ exchanger. Na+/H+ EXC was partially inhibited (80-100%) by dimethyl-amiloride (DMA) but basal or

  20. The NA62 trigger system

    NASA Astrophysics Data System (ADS)

    Krivda, M.; NA62 Collaboration

    2013-08-01

    The main aim of the NA62 experiment (NA62 Technical Design Report, na62.web.cern.ch/NA62/Documents/TD_Full_doc_v1.pdf> [1]) is to study ultra-rare Kaon decays. In order to select rare events over the overwhelming background, central systems with high-performance, high bandwidth, flexibility and configurability are necessary, that minimize dead time while maximizing data collection reliability. The NA62 experiment consists of 12 sub-detector systems and several trigger and control systems, for a total channel count of less than 100,000. The GigaTracKer (GTK) has the largest number of channels (54,000), and the Liquid Krypton (LKr) calorimeter shares with it the largest raw data rate (19 GB/s). The NA62 trigger system works with 3 trigger levels. The first trigger level is based on a hardware central trigger unit, so-called L0 Trigger Processor (L0TP), and Local Trigger Units (LTU), which are all located in the experimental cavern. Other two trigger levels are based on software, and done with a computer farm located on surface. The L0TP receives information from triggering sub-detectors asynchronously via Ethernet; it processes the information, and then transmits a final trigger decision synchronously to each sub-detector through the Trigger and Timing Control (TTC) system. The interface between L0TP and the TTC system, which is used for trigger and clock distribution, is provided by the Local Trigger Unit board (LTU). The LTU can work in two modes: global and stand-alone. In the global mode, the LTU provides an interface between L0TP and TTC system. In the stand-alone mode, the LTU can fully emulate L0TP and so provides an independent way for each sub-detector for testing or calibration purposes. In addition to the emulation functionality, a further functionality is implemented that allows to synchronize the clock of the LTU with the L0TP and the TTC system. For testing and debugging purposes, a Snap Shot Memory (SSM) interface is implemented, that can work

  1. Europlanet NA2 Science Networking

    NASA Astrophysics Data System (ADS)

    Harri, Ari-Matti; Szego, Karoly; Genzer, Maria; Schmidt, Walter; Krupp, Norbert; Lammer, Helmut; Kallio, Esa; Haukka, Harri

    2013-04-01

    Europlanet RI / NA2 Science Networking [1] focused on determining the major goals of current and future European planetary science, relating them to the Research Infrastructure that the Europlanet RI project [2] developed, and placing them in a more global context. NA2 also enhanced the ability of European planetary scientists to participate on the global scene with their own agenda-setting projects and ideas. The Networking Activity NA2 included five working groups, aimed at identifying key science issues and producing reference books on major science themes that will bridge the gap between the results of present and past missions and the scientific preparation of the future ones. Within the Europlanet RI project (2009-2012) the NA2 and NA2-WGs organized thematic workshops, an expert exchange program and training groups to improve the scientific impact of this Infrastructure. The principal tasks addressed by NA2 were: • Science activities in support to the optimal use of data from past and present space missions, involving the broad planetary science community beyond the "space club" • Science activities in support to the preparation of future planetary missions: Earth-based preparatory observations, laboratory studies, R&D on advanced instrumentation and exploration technologies for the future, theory and modeling etc. • Develop scientific activities, joint publications, dedicated meetings, tools and services, education activities, engaging the public and industries • Update science themes and addressing the two main scientific objectives • Prepare and support workshops of the International Space Science Institute (ISSI) in Bern and • Support Trans National Activities (TNAs), Joined Research Activities (JRAs) and the Integrated and Distributed Information Service (IDIS) of the Europlanet project These tasks were achieved by WG workshops organized by the NA2 working groups, by ISSI workshops and by an Expert Exchange Program. There were 17 official WG

  2. Sodium iron hexacyanoferrate with high Na content as a Na-rich cathode material for Na-ion batteries

    SciTech Connect

    You, Ya; Yu, Xi -Qian; Yin, Ya -Xia; Nam, Kyung -Wan; Guo, Yu -Guo

    2014-10-27

    Owing to the worldwide abundance and low-cost of Na, room-temperature Na-ion batteries are emerging as attractive energy storage systems for large-scale grids. Increasing the Na content in cathode material is one of the effective ways to achieve high energy density. Prussian blue and its analogues (PBAs) are promising Na-rich cathode materials since they can theoretically store two Na ions per formula. However, increasing the Na content in PBAs cathode materials is a big challenge in the current. Here we show that sodium iron hexacyanoferrate with high Na content could be obtained by simply controlling the reducing agent and reaction atmosphere during synthesis. The Na content can reach as high as 1.63 per formula, which is the highest value for sodium iron hexacyanoferrate. This Na-rich sodium iron hexacyanoferrate demonstrates a high specific capacity of 150 mA h g-1 and remarkable cycling performance with 90% capacity retention after 200 cycles. Furthermore, the Na intercalation/de-intercalation mechanism is systematically studied by in situ Raman, X-ray diffraction and X-ray absorption spectroscopy analysis for the first time. As a result, the Na-rich sodium iron hexacyanoferrate could function as a plenteous Na reservoir and has great potential as a cathode material toward practical Na-ion batteries.

  3. Sodium iron hexacyanoferrate with high Na content as a Na-rich cathode material for Na-ion batteries

    DOE PAGESBeta

    You, Ya; Yu, Xi -Qian; Yin, Ya -Xia; Nam, Kyung -Wan; Guo, Yu -Guo

    2014-10-27

    Owing to the worldwide abundance and low-cost of Na, room-temperature Na-ion batteries are emerging as attractive energy storage systems for large-scale grids. Increasing the Na content in cathode material is one of the effective ways to achieve high energy density. Prussian blue and its analogues (PBAs) are promising Na-rich cathode materials since they can theoretically store two Na ions per formula. However, increasing the Na content in PBAs cathode materials is a big challenge in the current. Here we show that sodium iron hexacyanoferrate with high Na content could be obtained by simply controlling the reducing agent and reaction atmospheremore » during synthesis. The Na content can reach as high as 1.63 per formula, which is the highest value for sodium iron hexacyanoferrate. This Na-rich sodium iron hexacyanoferrate demonstrates a high specific capacity of 150 mA h g-1 and remarkable cycling performance with 90% capacity retention after 200 cycles. Furthermore, the Na intercalation/de-intercalation mechanism is systematically studied by in situ Raman, X-ray diffraction and X-ray absorption spectroscopy analysis for the first time. As a result, the Na-rich sodium iron hexacyanoferrate could function as a plenteous Na reservoir and has great potential as a cathode material toward practical Na-ion batteries.« less

  4. Ionic regulation of Na absorption in proximal colon: cation inhibition of electroneutral Na absorption

    SciTech Connect

    Sellin, J.H.; De Soignie, R.

    1987-01-01

    Active Na absorption (J/sub net//sup NA/) in rabbit proximal colon in vitro is paradoxically stimulated as (Na) in the bathing media is lowered with constant osmolarity. J/sub m..-->..s//sup Na/ increases almost linearly from 0 to 50 mM (Na)/sub 0/ but then plateaus and actually decreases from 50 to 140 mM (Na)/sub 0/, consistent with inhibition of an active transport process. Both lithium and Na are equally effective inhibitors of J/sub net//sup Na/, whereas choline and mannitol do not block the high rate of J/sub net//sup Na/ observed in decreased (Na)/sub 0/. Either gluconate or proprionate replacement of Cl inhibits J/sub net//sup Na/. J/sub net//sup Na/ at lowered (Na)/sub 0/ is electrically silent and is accompanied by increased Cl absorption; it is inhibited by 10/sup -3/ M amiloride and 10/sup -3/ theophylline but not by 10/sup -4/ M bumetanide. Epinephrine is equally effective at stimulating Na absorption at 50 and 140 mM (Na). Na gradient experiments are consistent with a predominantly serosal effect of the decreased (Na)/sub 0/. These results suggest that 1) Na absorption in rabbit proximal colon in vitro is stimulated by decreased (Na); 2) the effect is cation specific, both Na and Li blocking the stimulatory effect; 3) the transport is mediated by Na-H exchange and is Cl dependent but 4) is under different regulatory mechanisms than the epinephrine-sensitive Na-Cl cotransport previously described in proximal colon. Under the appropriate conditions, proximal colon absorbs Na extremely efficiently. Na-H exchange in this epithelium is cation inhibitable, either directly or by a secondary regulatory process.

  5. Single crystal growth of type I Na-Si clathrate by using Na-Sn flux

    NASA Astrophysics Data System (ADS)

    Morito, Haruhiko; Shimoda, Masashi; Yamane, Hisanori

    2016-09-01

    Single crystals of type I Na-Si clathrate, Na8Si46, were synthesized by heating Na, Na4Si4, and Na15Sn4 at 723 K under an Ar gas pressure of 104 Pa for 12 h. The single crystals having {110} habit planes grew up to 1.5 mm in size due to Na evaporation from a Na-Si-Sn melt with a starting compositional molar ratio of Na/Si/Sn=5.75:2:1.

  6. Deliquescence of NaCl-NaNO3 and KNO3-NaNO3 Salt Mixtures at 90C

    SciTech Connect

    Carroll, S; Craig, L; Wolery, T

    2003-12-29

    We conducted reversed deliquescence experiments in saturated NaCl-NaNO3-H2O and KNO{sub 3}-NaNO{sub 3}-H{sub 2}O systems at 90 C to determine relative humidity and solution composition. NaCl, NaNO{sub 3}, and KNO{sub 3} represent members of dust salt assemblages that are likely to deliquesce and form concentrated brines on high-level radioactive waste package surfaces in a repository environment at Yucca Mountain, NV, USA. Model predictions agree with experimental results for the NaCl-NaNO{sub 3}-H{sub 2}O system, but underestimate relative humidity by as much as 8% and solution composition by as much as 50% in the KNO{sub 3}-NaNO{sub 3}-H{sub 2}O system.

  7. Antibiotic resistance and mecA characterization of coagulase-negative staphylococci isolated from three hotels in London, UK.

    PubMed

    Xu, Zhen; Mkrtchyan, Hermine V; Cutler, Ronald R

    2015-01-01

    Antibiotic resistance in bacteria isolated from non-healthcare environments, is a potential problem to public health. In our survey a total of 71 coagulase negative staphylococci (CNS) belonging to 11 different species were isolated from three large hotels in London, UK. The most prevalent species was Staphylococcus haemolyticus, with S. hominis, S. warneri, S. cohnii, and Staphylococcus epidermidis commonly detected. Antimicrobial susceptibilities and carriage of the mecA gene were determined for all of these isolates. Most (85.9%) staphylococci were resistant to multiple antibiotics with all displaying increased susceptibility toward penicillin, fusidic acid, erythromycin, and cefepime. Twenty-one (29.5%) of the isolates were mecA positive, however MIC values to oxacillin, normally associated with the carriage of mecA, varied widely in this group (from 0.06 to 256 mg/L). Fifteen of the twenty-one mecA positive isolates carried SCCmec of these seven were type V, one type I, one type II, and one type IV. Additionally, five of these 15 isolates carried a previously unreported type, 1A, which involves an association between class A mec complex and ccr type 1. The remaining six of the 21 isolates were non-typeable and carried a combination of class A mec complex and ccrC. In addition to this, we also report on new MLST types which were assigned for five S. epidermidis isolates. Four out of these five isolates had MICs between 0.06 and 256 mg/L to oxacillin and would be regarded as clinically susceptible but one isolate had a high oxacillin MIC of 256 mg/L. We demonstrated widespread multiple drug resistance among different staphylococcal species isolated from non-healthcare environments highlighting the potential for these species to act as a reservoir for methicillin and other forms of drug resistance. PMID:26441881

  8. Antibiotic resistance and mecA characterization of coagulase-negative staphylococci isolated from three hotels in London, UK.

    PubMed

    Xu, Zhen; Mkrtchyan, Hermine V; Cutler, Ronald R

    2015-01-01

    Antibiotic resistance in bacteria isolated from non-healthcare environments, is a potential problem to public health. In our survey a total of 71 coagulase negative staphylococci (CNS) belonging to 11 different species were isolated from three large hotels in London, UK. The most prevalent species was Staphylococcus haemolyticus, with S. hominis, S. warneri, S. cohnii, and Staphylococcus epidermidis commonly detected. Antimicrobial susceptibilities and carriage of the mecA gene were determined for all of these isolates. Most (85.9%) staphylococci were resistant to multiple antibiotics with all displaying increased susceptibility toward penicillin, fusidic acid, erythromycin, and cefepime. Twenty-one (29.5%) of the isolates were mecA positive, however MIC values to oxacillin, normally associated with the carriage of mecA, varied widely in this group (from 0.06 to 256 mg/L). Fifteen of the twenty-one mecA positive isolates carried SCCmec of these seven were type V, one type I, one type II, and one type IV. Additionally, five of these 15 isolates carried a previously unreported type, 1A, which involves an association between class A mec complex and ccr type 1. The remaining six of the 21 isolates were non-typeable and carried a combination of class A mec complex and ccrC. In addition to this, we also report on new MLST types which were assigned for five S. epidermidis isolates. Four out of these five isolates had MICs between 0.06 and 256 mg/L to oxacillin and would be regarded as clinically susceptible but one isolate had a high oxacillin MIC of 256 mg/L. We demonstrated widespread multiple drug resistance among different staphylococcal species isolated from non-healthcare environments highlighting the potential for these species to act as a reservoir for methicillin and other forms of drug resistance.

  9. Development and application of a channelized Hotelling observer for DBT optimization on structured background test images with mass simulating targets

    NASA Astrophysics Data System (ADS)

    Petrov, Dimitar; Michielsen, Koen; Cockmartin, Lesley; Zhang, Gouzhi; Young, Kenneth; Marshall, Nicholas; Bosmans, Hilde

    2016-03-01

    Digital breast tomosynthesis (DBT) is a 3D mammography technique that promises better visualization of low contrast lesions than conventional 2D mammography. A wide range of parameters influence the diagnostic information in DBT images and a systematic means of DBT system optimization is needed. The gold standard for image quality assessment is to perform a human observer experiment with experienced readers. Using human observers for optimization is time consuming and not feasible for the large parameter space of DBT. Our goal was to develop a model observer (MO) that can predict human reading performance for standard detection tasks of target objects within a structured phantom and subsequently apply it in a first comparative study. The phantom consists of an acrylic semi-cylindrical container with acrylic spheres of different sizes and the remaining space filled with water. Three types of lesions were included: 3D printed spiculated and non-spiculated mass lesions along with calcification groups. The images of the two mass lesion types were reconstructed with 3 different reconstruction methods (FBP, FBP with SRSAR, MLTRpr) and read by human readers. A Channelized Hotelling model observer was created for the non-spiculated lesion detection task using five Laguerre-Gauss channels, tuned for better performance. For the non-spiculated mass lesions a linear relation between the MO and human observer results was found, with correlation coefficients of 0.956 for standard FBP, 0.998 for FBP with SRSAR and 0.940 for MLTRpr. Both the MO and human observer percentage correct results for the spiculated masses were close to 100%, and showed no difference from each other for every reconstruction algorithm.

  10. Comparison of Channelized Hotelling and Human Observers inDetermining Optimum OS-EM Reconstruction Parameters for MyocardialSPECT

    SciTech Connect

    Gilland, Karen L.; Tsui, Benjamin M.W.; Qi, Yujin; Gullberg,Grant T.

    2005-07-01

    The performance of the Channelized Hotelling Observer (CHO)was compared to that of human observers for determining optimumparameters for the iterative OS-EM image reconstruction method for thetask of defect detection in myocardial SPECT images. The optimumparameters were those that maximized defect detectability in the SPECTimages. Low noise, parallel SPECT projection data, with and without ananterior, inferior or lateral LV wall defect, were simulated using theMonte Carlo method. Poisson noise was added to generate noisyrealizations. Data were reconstructed using OS-EM at 1&4subsets/iteration and at 1, 3, 5, 7&9 iterations. Images wereconverted to 2D short-axis slices with integer pixel values. The CHO used3 radially-symmetric, 2D channels, with varying levels of internalobserver noise. For each parameter setting, 600 defect-present and 600defect-absent image vectors were used to calculate the detectabilityindex (dA). The human observers rated the likelihood that a defect waspresent in a specified location. For each parameter setting, the AUC wasestimated from 48 defect-present and 48 defect-absent images. Thecombined human observer results showed the optimum parameter settingcould be in the range 5-36 updates ([number of subsets]/iteration enumber of iterations). The CHO results showed the optimum parametersetting to be 4-5 updates. The performance of the CHO was much moresensitive to the reconstruction parameter setting than was that of thehuman observers. The rankings of the CHO detectability values did notchange with varying levels of internal noise.

  11. Actual Condition Evaluation of Cogeneration System in an Urbanized Hotel, and Study of the Optimal Operation to Minimize the CO2 Emission

    NASA Astrophysics Data System (ADS)

    Katsuta, Masafumi; Kaneko, Akira; Yamamoto, Toru

    Recently, there is an important subject to reduce of the CO2 emission discharged from a building. A cogeneration system (CGS) is one of the effective facilities to reduce of the CO2 emission, but prudent consideration is required in design and operation. Because it is necessary to be matching electric demand and heat demand in order to obtain the high efficiency. In this paper, it is evaluated the power generation efficiency and heat recovery one of CGS in the actual urbanized hotel as measurement result. In addition, the optimal operation analysis is carried out in order to minimize CO2 emission in the present facility.

  12. Compensatory regulation of Na+ absorption by Na+/H+ exchanger and Na+-Cl- cotransporter in zebrafish (Danio rerio)

    PubMed Central

    2013-01-01

    Introduction In mammals, internal Na+ homeostasis is maintained through Na+ reabsorption via a variety of Na+ transport proteins with mutually compensating functions, which are expressed in different segments of the nephrons. In zebrafish, Na+ homeostasis is achieved mainly through the skin/gill ionocytes, namely Na+/H+ exchanger (NHE3b)-expressing H+-ATPase rich (HR) cells and Na+-Cl- cotransporter (NCC)-expressing NCC cells, which are functionally homologous to mammalian proximal and distal convoluted tubular cells, respectively. The present study aimed to investigate whether or not the functions of HR and NCC ionocytes are differentially regulated to compensate for disruptions of internal Na+ homeostasis and if the cell differentiation of the ionocytes is involved in this regulation pathway. Results Translational knockdown of ncc caused an increase in HR cell number and a resulting augmentation of Na+ uptake in zebrafish larvae, while NHE3b loss-of-function caused an increase in NCC cell number with a concomitant recovery of Na+ absorption. Environmental acid stress suppressed nhe3b expression in HR cells and decreased Na+ content, which was followed by up-regulation of NCC cells accompanied by recovery of Na+ content. Moreover, knockdown of ncc resulted in a significant decrease of Na+ content in acid-acclimated zebrafish. Conclusions These results provide evidence that HR and NCC cells exhibit functional redundancy in Na+ absorption, similar to the regulatory mechanisms in mammalian kidney, and suggest this functional redundancy is a critical strategy used by zebrafish to survive in a harsh environment that disturbs body fluid Na+ homeostasis. PMID:23924428

  13. The hydrogen storage properties of Na decorated small boron cluster B6Na8

    NASA Astrophysics Data System (ADS)

    Tang, Chunmei; Wang, Zhiguo; Zhang, Xue; Wen, Ninghua

    2016-09-01

    The binding energy of the Na atoms to the hollow sites of the B6 cage is larger than the experimental cohesive energy of bulk Na, so the clustering of Na atoms can be avoided. The polarization interaction dominates the adsorption of H2 by the B6Na8 cluster. The Na-coated B6Na8sbnd B8sbnd B6Na8 complex with the dispersive Na atoms and four H2 molecules adsorbed per Na can serve as better building blocks of polymers than the (B6Na8)2 dimer. These findings suggest a new route to design cluster-assembled hydrogen storage materials based on sp2-terminated boron chains.

  14. Silicene for Na-ion battery applications

    NASA Astrophysics Data System (ADS)

    Zhu, Jiajie; Schwingenschlögl, Udo

    2016-09-01

    Na-ion batteries are promising candidates to replace Li-ion batteries in large scale applications because of the advantages in natural abundance and cost of Na. Silicene has potential as the anode in Li-ion batteries but so far has not received attention with respect to Na-ion batteries. In this context, freestanding silicene, a graphene-silicene-graphene heterostructure, and a graphene-silicene superlattice are investigated for possible application in Na-ion batteries, using first-principles calculations. The calculated Na capacities of 954 mAh/g for freestanding silicene and 730 mAh/g for the graphene-silicene superlattice (10% biaxial tensile strain) are highly competitive and potentials of \\gt 0.3 {{V}} against the Na{}+/Na potential exceed the corresponding value of graphite. In addition, the diffusion barriers are predicted to be \\lt 0.3 {eV}.

  15. WE-E-18A-09: Application of a Channelized Hotelling Observer Model to Evaluate Angiographic Imaging Equipment

    SciTech Connect

    Favazza, C; Fetterly, K; Hangiandreou, N; Leng, S; Schueler, B

    2014-06-15

    Purpose: To develop and apply an observer model to objectively evaluate and compare the performance of different angiographic imaging equipment and acquisition variables. Methods: Image Acquisition— Iodine-based phantoms were created with target diameters: 0.5, 1, 2, and 4 mm. The phantoms were imaged using both planes of a bi-plane angiography system with detector pixel dimensions 0.1542 mm{sup 2} and 0.1842 mm{sup 2}, respectively. All four phantoms were imaged with magnification factors 1.5, 1.25 and 1 and with the large and small focal spots. Phantom position and the dose per frame (0.12– 0.24 μ Gy/frame) were varied for a single phantom size, magnification and focal spot. Observer Model— For each experimental condition, 1200 signal-present and signal-absent images were acquired and a detectability index (d') was calculated with a Gabor-channelized Hotelling observer (CHO) model. Detectability indices were evaluated as a function of dose, phantom size, and magnification. The model was then applied to compare d' of the two imaging planes and focal spots. Uncertainty in d' was estimated by bootstrapping the data and by examining the shift-variance of systems. Results: Detectability indices varied linearly with magnification and the square root of dose. For the 2 and 4 mm phantoms, d' varied linearly with diameter. For the 0.5 and 1 mm phantoms, d' expectedly deviated from this linear relationship due to substantial detector and focal spot blurring of the phantoms. The small focal spot yielded up to 50% greater d' values than the large focal spot. For the two detectors, differences in d' did not exceed the estimated ∼7% error. Conclusions: The detectability indices predictably scaled with dose, diameter, magnification, and focal spot size and serve to validate the model. Results demonstrate statistically similar target detectability for both investigated detectors, despite differences in pixel dimensions. This CHO model provides a framework to evaluate

  16. Vocational Education and Training for the Hotel and Catering Industry in the Federal Republic of Germany. Report of a Visiting Party. Studies in Vocational Education and Training in the Federal Republic of Germany. Number Eight.

    ERIC Educational Resources Information Center

    Ripper, Chris, Ed.; Russell, Russ, Ed.

    A party of vocational educators from the United Kingdom (UK) traveled to the Federal Republic of Germany (FRG) to examine West German vocational education and training for the hotel and catering industry. During the study, the investigators examined the training with respect to regulations, the content of training, and the structure of the…

  17. The effect of Na vapor on the Na content of chondrules

    NASA Technical Reports Server (NTRS)

    Lewis, R. Dean; Lofgren, Gary E.; Franzen, Hugo F.; Windom, Kenneth E.

    1993-01-01

    Chondrules contain higher concentrations of volatiles (Na) than expected for melt droplets in the solar nebula. Recent studies have proposed that chondrules may have formed under non-canonical nebular conditions such as in particle/gas-rich clumps. Such chondrule formation areas may have contained significant Na vapor. To test the hypothesis of whether a Na-rich vapor would minimize Na volatilization reaction rates in a chondrule analog and maintain the Na value of the melt, experiments were designed where a Na-rich vapor could be maintained around the sample. A starting material with a melting point lower that typical chondrules was required to keep the logistics of working with Na volatilization from NaCl within the realm of feasibility. The Knippa basalt, a MgO-rich alkali olivine basalt with a melting temperature of 1325 +/- 5 C and a Na2O content of 3.05 wt%, was used as the chondrule analog. Experiments were conducted in a 1 atm, gas-mixing furnace with the fO2 controlled by a CO/CO2 gas mixture and fixed at the I-W buffer curve. To determine the extent of Na loss from the sample, initial experiments were conducted at high temperatures (1300 C - 1350 C) for duration of up to 72 h without a Na-rich vapor present. Almost all (up to 98%) Na was volatilized in runs of 72 h. Subsequent trials were conducted at 1330 C for 16 h in the presence of a Na-rich vapor, supplied by a NaCl-filled crucible placed in the bottom of the furnace. Succeeding Knudsen cell weight-loss mass-spectrometry analysis of NaCl determined the P(sub Na) for these experimental conditions to be in the 10(exp -6) atm range. This value is considered high for nebula conditions but is still plausible for non-canonical environments. In these trials the Na2O content of the glass was maintained or in some cases increased; Na2O values ranged from 2.62% wt to 4.37% wt. The Na content of chondrules may be controlled by the Na vapor pressure in the chondrule formation region. Most heating events capable

  18. Effect of colchicine on sensitivity of duck salt gland Na,K-ATPase to Na+.

    PubMed

    Yakushev, S S; Kumskova, E M; Rubtsov, A M; Lopina, O D

    2008-09-01

    Low molecular mass proteins of the FXYD family that affect the sensitivity of Na,K-ATPase to Na+ and K+ are known to be present in Na,K-ATPases in various tissues. In particular, in Na,K-ATPase from kidney a gamma-subunit (with electrophoretic mobility corresponding to molecular mass of about 10 kD) is present, and Na,K-ATPase preparations from heart contain phospholemman (electrophoretic mobility of this protein corresponds to molecular mass of 13-14 kD), which provides for the interaction of heart Na,K-ATPase with cytoskeletal microtubules. Disruption of microtubules by colchicine removes phospholemman from heart Na,K-ATPase preparations. The goal of the present study was to reveal a low molecular mass protein (probably a member of FXYD family) in preparation of Na,K-ATPase from duck salt glands. Immunoprecipitation of solubilized duck salt gland Na,K-ATPase using antibodies against alpha1-subunit results in the coprecipitation of a 13 kD protein with the Na,K-ATPase complex. Treatment of homogenate from duck salt glands with colchicine removes this protein from the purified preparation of Na,K-ATPase. Simultaneously, we observed a decrease in the sensitivity of Na,K-ATPase to Na+ at pH 6.5. However, colchicine treatment of homogenate from rabbit kidney does not affect either the sensitivity of Na,K-ATPase obtained from this homogenate to Na+ or the content of 10 kD protein (presumably gamma-subunit). The data suggest that phospholemman (or a similar member of the FXYD family) tightly interacts with Na,K-ATPase from duck salt glands and binds it to microtubules, simultaneously participating in the regulation of the sensitivity of Na,K-ATPase to Na+. PMID:18976215

  19. Growth of binary organic NLO crystals: m.NA-p.NA and m.NA-CNA system

    NASA Technical Reports Server (NTRS)

    Singh, N. B.; Henningsen, T.; Hopkins, R. H.; Mazelsky, R.

    1993-01-01

    Experiments were carried out to grow 3.Nitroaniline (m.NA) crystals doped with 4.Nitroaniline (p.NA) and 2.chloro 4.Nitroaniline (CNA). The measured undercooling for m.NA, p.NA, and CNA were 0.21 tm K, 0.23 tm K, and 0.35 tm K respectively, where tm represents the melting temperature of the pure component. Because of the crystals' large heat of fusion and large undercooling, it was not possible to grow good quality crystals with low thermal gradients. In the conventional two-zone Bridgman furnace we had to raise the temperature of the hot zone above the decomposition temperature of CNA, p.NA, and m.NA to achieve the desired thermal gradient. To avoid decomposition, we used an unconventional Bridgman furnace. Two immiscible liquids, silicone oil and ethylene glycol, were used to build a special two-zone Bridgman furnace. A temperature gradient of 18 K/cm was achieved without exceeding the decomposition temperature of the crystal. The binary crystals, m.NA-p.NA and m.NA-CNA, were grown in centimeter size in this furnace. X-ray and optical characterization showed good optical quality.

  20. Maintaining the Na atmosphere of Mercury

    NASA Technical Reports Server (NTRS)

    Killen, Rosemary M.; Morgan, Thomas H.

    1993-01-01

    The possible sources of the Na atmosphere of Mercury are calculatively studied. The likely structure, composition, and temperature of the planet's upper crust is examined along with the probable flux of Na from depth by grain boundary diffusion and by Knudsen flow. The creation of fresh regolith is considered along with mechanisms for supplying Na from the surface to the exosphere. The implications of the calculations for the probable abundances in the regolith are discussed.

  1. Colonic H(+)-K(+)-ATPase in K(+) conservation and electrogenic Na(+) absorption during Na(+) restriction.

    PubMed

    Spicer, Z; Clarke, L L; Gawenis, L R; Shull, G E

    2001-12-01

    Upregulation of the colonic H(+)-K(+)- ATPase (cHKA) during hyperaldosteronism suggests that it functions in both K(+) conservation and electrogenic Na(+) absorption in the colon when Na(+)-conserving mechanisms are activated. To test this hypothesis, wild-type (cHKA(+/+)) and cHKA-deficient (cHKA(-/-)) mice were fed Na(+)-replete and Na(+)-restricted diets and their responses were analyzed. In both genotypes, Na(+) restriction led to reduced plasma Na(+) and increased serum aldosterone, and mRNAs for the epithelial Na(+) channel (ENaC) beta- and gamma-subunits, channel-inducing factor, and cHKA were increased in distal colon. Relative to wild-type controls, cHKA(-/-) mice on a Na(+)-replete diet had elevated fecal K(+) excretion. Dietary Na(+) restriction led to increased K(+) excretion in knockout but not in wild-type mice. The amiloride-sensitive, ENaC-mediated short-circuit current in distal colon was significantly reduced in knockout mice maintained on either the Na(+)-replete or Na(+)-restricted diet. These results demonstrate that cHKA plays an important role in K(+) conservation during dietary Na(+) restriction and suggest that cHKA-mediated K(+) recycling across the apical membrane is required for maximum electrogenic Na(+) absorption. PMID:11705741

  2. Ionic dependence of active Na-K transport: "clamping" of cellular Na+ with monensin.

    PubMed

    Haber, R S; Pressley, T A; Loeb, J N; Ismail-Beigi, F

    1987-07-01

    The Na+ ionophore monensin was used to study the Na+- and K+-dependence of ouabain-inhibitable 86Rb+ uptake in ARL 15 cells, a rat liver cell line. Graded concentrations of monensin rapidly induced incremental elevations of cellular Na+ that were stable for up to 2 h. In experiments in which cellular Na+ was thus "clamped" at various levels, the activation curve for ouabain-inhibitable 86Rb+ uptake as a function of intracellular Na+ was found to be steepest near basal Na+ levels (Hill coefficient approximately equal to 2.4), indicating that these cells can respond to relatively large changes in passive Na+ entry by increasing the race of Na-K pump function with only minimal increases in cellular Na+. Exposure of cells to monensin also permitted examination of the extracellular-K+ dependence of ouabain-inhibitable 86Rb+ uptake in the presence of saturating intracellular Na+ and yielded a Hill coefficient of approximately 1.5. The rate of ATP hydrolysis calculated from measurements of the maximal rate of ouabain-inhibitable 86Rb+ uptake in intact cells was similar to the enzymatic Vmax of the Na+-K+-ATPase in cell lysates, suggesting that the Na+-K+-ATPase activity in these broken-cell preparations closely reflects the functional transport capacity of the Na-K pump.

  3. NA-NET numerical analysis net

    SciTech Connect

    Dongarra, J. |; Rosener, B.

    1991-12-01

    This report describes a facility called NA-NET created to allow numerical analysts (na) an easy method of communicating with one another. The main advantage of the NA-NET is uniformity of addressing. All mail is addressed to the Internet host ``na-net.ornl.gov`` at Oak Ridge National Laboratory. Hence, members of the NA-NET do not need to remember complicated addresses or even where a member is currently located. As long as moving members change their e-mail address in the NA-NET everything works smoothly. The NA-NET system is currently located at Oak Ridge National Laboratory. It is running on the same machine that serves netlib. Netlib is a separate facility that distributes mathematical software via electronic mail. For more information on netlib consult, or send the one-line message ``send index`` to netlib{at}ornl.gov. The following report describes the current NA-NET system from both a user`s perspective and from an implementation perspective. Currently, there are over 2100 members in the NA-NET. An average of 110 mail messages pass through this facility daily.

  4. NA-NET numerical analysis net

    SciTech Connect

    Dongarra, J. . Dept. of Computer Science Oak Ridge National Lab., TN ); Rosener, B. . Dept. of Computer Science)

    1991-12-01

    This report describes a facility called NA-NET created to allow numerical analysts (na) an easy method of communicating with one another. The main advantage of the NA-NET is uniformity of addressing. All mail is addressed to the Internet host na-net.ornl.gov'' at Oak Ridge National Laboratory. Hence, members of the NA-NET do not need to remember complicated addresses or even where a member is currently located. As long as moving members change their e-mail address in the NA-NET everything works smoothly. The NA-NET system is currently located at Oak Ridge National Laboratory. It is running on the same machine that serves netlib. Netlib is a separate facility that distributes mathematical software via electronic mail. For more information on netlib consult, or send the one-line message send index'' to netlib{at}ornl.gov. The following report describes the current NA-NET system from both a user's perspective and from an implementation perspective. Currently, there are over 2100 members in the NA-NET. An average of 110 mail messages pass through this facility daily.

  5. Painful Na-channelopathies: an expanding universe.

    PubMed

    Waxman, Stephen G

    2013-07-01

    The universe of painful Na-channelopathies--human disorders caused by mutations in voltage-gated sodium channels--has recently expanded in three dimensions. We now know that mutations of sodium channels cause not only rare genetic 'model disorders' such as inherited erythromelalgia and channelopathy-associated insensitivity to pain but also common painful neuropathies. We have learned that mutations of NaV1.8, as well as mutations of NaV1.7, can cause painful Na-channelopathies. Moreover, recent studies combining atomic level structural models and pharmacogenomics suggest that the goal of genomically guided pain therapy may not be unrealistic.

  6. NaHCO3 and NaC1 tolerance in chronic renal failure.

    PubMed

    Husted, F C; Nolph, K D; Maher, J F

    1975-08-01

    In patients with chronic renal failure, NaHCO3 therapy may correct or prevent acidemia. It has been proposed that the NaHCO3 required will not result in clinically significant Na retention comparable to that from similar increases in NaC1 intake. In each of ten patients with chronic renal failure, creatinine clearance (Ccr) range 2.5-16.8 ml/min, on an estimated 10-meq Na and C1 diet, electrolyte excretion was compared on NaHCO3 vs NaC1 supplements of 200 meq/day. Periods of NaHCO3 and NaC1 (in alternate order for successive patients) lasted 4 days, separated by reequilibration to base-line weight. Mean +/- SEM excretion (ex) of Na, C1, and HCO3 and deltaCcr and deltaweight (day 4-1) are compared below for the 4th day of NaC1 vs. NaHCO3 intake. Mean Ccr +/-SEM on day 4 of NaC1 and NaHCO3 were 10.8 +/-1.6 and 9.0 +/-1.4 ml/min, respectively (P less than 0.02). Mean systolic blood pressure (but not diastolic) increased significantly on NaC1 (P less than 0.05). No significant blood pressure changes were seen on NaHCO3. Net positive HCO3 balance occurred on NaHCO3 as indicated above and reflected a rise in mean serum HCO3 from 19 to 30 meq/liter (day 1 vs. 4) (P less than 0.01). Mechanisms for the greater excretion of Na on NaHCO3 may relate to C1 wasting as noted above on low C1 intake and limited HCO3 reabsorptive capacity. Thus, Na excretion by day 4 was greater on NaHCO3 than on NaHCO3 did Na excretion near intake (210 meq/day).

  7. Aquifer-test evaluation and potential effects of increased ground-water pumpage at the Stovepipe Wells Hotel area, Death Valley National Monument, California

    USGS Publications Warehouse

    Woolfenden, L.R.; Martin, Peter; Baharie, Brian

    1988-01-01

    Ground-water use in the Stovepipe Wells Hotel area in Death Valley National Monument is expected to increase significantly if the nonpotable, as well as potable, water supply is treated by reverse osmosis. During the peak tourist season, October through March, ground-water pumpage could increase by 37,500 gallons per day, or 76%. The effects of this additional pumpage on water levels in the area, particularly near a strand of phreatophytes about 10,000 feet east of the well field, are of concern. In order to evaluate the effects of increased pumpage on water levels in the Stovepipe Wells Hotel area well field, two aquifer tests were performed at the well field to determine the transmissivity and storage coefficients of the aquifer. Analysis of the aquifer test determined that a transmissivity of 1,360 feet squared per day was representative of the aquifer. The estimated value of transmissivity and the storage-coefficient values that are representative of confined (1.2 x .0004) and unconfined (0.25) conditions were used in the Theis equation to calculate the additional drawdown that might occur after 1, 10, and 50 years of increased pumpage. The drawdown calculated by using the lower storage-coefficient value represents the maximum additional drawdown that might be expected from the assumed increase in pumpage; the drawdown calculated by using the higher storage-coefficient value represents the minimum additional drawdown. Calculated additional drawdowns after 50 years of pumping range from 7.8 feet near the pumped well to 2.4 feet at the phreatophyte stand assuming confined conditions, and from 5.7 feet near the pumped well to 0.3 foot at the phreatophyte stand assuming unconfined conditions. Actual drawdowns probably will be somewhere between these values. Drawdowns measured in observation wells during 1973-85, in response to an average pumpage of 34,200 gallons per day at the Stovepipe Wells Hotel well field, are similar to the drawdowns calculated by the Theis

  8. Na+/Ca2+ exchange and Na+/K+-ATPase in the heart

    PubMed Central

    Shattock, Michael J; Ottolia, Michela; Bers, Donald M; Blaustein, Mordecai P; Boguslavskyi, Andrii; Bossuyt, Julie; Bridge, John H B; Chen-Izu, Ye; Clancy, Colleen E; Edwards, Andrew; Goldhaber, Joshua; Kaplan, Jack; Lingrel, Jerry B; Pavlovic, Davor; Philipson, Kenneth; Sipido, Karin R; Xie, Zi-Jian

    2015-01-01

    This paper is the third in a series of reviews published in this issue resulting from the University of California Davis Cardiovascular Symposium 2014: Systems approach to understanding cardiac excitation–contraction coupling and arrhythmias: Na+ channel and Na+ transport. The goal of the symposium was to bring together experts in the field to discuss points of consensus and controversy on the topic of sodium in the heart. The present review focuses on cardiac Na+/Ca2+ exchange (NCX) and Na+/K+-ATPase (NKA). While the relevance of Ca2+ homeostasis in cardiac function has been extensively investigated, the role of Na+ regulation in shaping heart function is often overlooked. Small changes in the cytoplasmic Na+ content have multiple effects on the heart by influencing intracellular Ca2+ and pH levels thereby modulating heart contractility. Therefore it is essential for heart cells to maintain Na+ homeostasis. Among the proteins that accomplish this task are the Na+/Ca2+ exchanger (NCX) and the Na+/K+ pump (NKA). By transporting three Na+ ions into the cytoplasm in exchange for one Ca2+ moved out, NCX is one of the main Na+ influx mechanisms in cardiomyocytes. Acting in the opposite direction, NKA moves Na+ ions from the cytoplasm to the extracellular space against their gradient by utilizing the energy released from ATP hydrolysis. A fine balance between these two processes controls the net amount of intracellular Na+ and aberrations in either of these two systems can have a large impact on cardiac contractility. Due to the relevant role of these two proteins in Na+ homeostasis, the emphasis of this review is on recent developments regarding the cardiac Na+/Ca2+ exchanger (NCX1) and Na+/K+ pump and the controversies that still persist in the field. PMID:25772291

  9. Reduced Na+ uptake in the NaCl-hypersensitive sos1 mutant of Arabidopsis thaliana.

    PubMed Central

    Ding, L; Zhu, J K

    1997-01-01

    Sos1 is an Arabidopsis thaliana mutant with > 20 times higher sensitivity toward Na+ inhibition due to a defective high-affinity potassium-uptake system. We report here that sos1 accumulates less Na+ than the wild type in response to NaCl stress. The Na+ contents in sos1 seedlings exposed to 25 mM NaCl for 2 or more d are about 43% lower than those in the wild type. When assayed at 20 mM external NaCl, sos1 seedlings pretreated with low potassium have 32% lower Na+ uptake than the wild type. However, little difference in Na+ uptake could be measured when the seedlings were not pretreated with low potassium. Low-potassium treatment was shown to induce high-affinity potassium-uptake activity in Arabidopsis seedlings. No substantial difference in Na+ efflux between sos1 and the wild type was detected. The results show that the reduced Na+ accumulation in sos1 is due to a lower Na+ influx rate. Therefore, the sos1 mutation appears to disrupt low-affinity Na+ uptake in addition to its impairment of high-affinity K+ uptake. PMID:9085573

  10. Transactions of the twenty-third water reactor safety information meeting to be held at Bethesda Marriott Hotel, Bethesda, Maryland, October 23--25, 1995

    SciTech Connect

    Monteleone, S.

    1995-09-01

    This report contains summaries of papers on reactor safety research to be presented at the 23rd Water Reactor Safety Information Meeting at the Bethesda Marriott Hotel, Bethesda, Maryland, October 23--25, 1995. The summaries briefly describe the programs and results of nuclear safety research sponsored by the Office of Nuclear Regulatory, Research, US NRC. Summaries of invited papers concerning nuclear safety issues from US government laboratories, the electric utilities, the nuclear industry, and from foreign governments and industry are also included. The summaries have been compiled in one report to provide a basis for meaningful discussion and information exchange during the course of the meeting and are given in the order of their presentation in each session.

  11. The influence of corporate social responsibility, ability, reputation, and transparency on hotel customer loyalty in the U.S.: a gender-based approach.

    PubMed

    Kim, Sung-Bum; Kim, Dae-Young

    2016-01-01

    This research explored a conceptual framework incorporating interrelationships among corporate social responsibility (CSR), corporate ability (CA), corporate reputation (CR), and CSR-related transparency on customer loyalty within the hotel context. In this study, we also analyzed consumers' propensity to support CSR initiatives through the socio-demographic indicator of gender. We used independent sample t test and multiple regression analysis to test hypotheses based on 487 responses from American participants. Four antecedents (i.e., CSR, CA, CR, and transparency) exhibited favorable effects on customer loyalty. Among these four factors, the positively perceived CSR initiatives had a greater impact on customer loyalty. In addition, according to our findings, female participants were more likely to have a positive perception of the four antecedents than males. PMID:27652110

  12. The influence of corporate social responsibility, ability, reputation, and transparency on hotel customer loyalty in the U.S.: a gender-based approach.

    PubMed

    Kim, Sung-Bum; Kim, Dae-Young

    2016-01-01

    This research explored a conceptual framework incorporating interrelationships among corporate social responsibility (CSR), corporate ability (CA), corporate reputation (CR), and CSR-related transparency on customer loyalty within the hotel context. In this study, we also analyzed consumers' propensity to support CSR initiatives through the socio-demographic indicator of gender. We used independent sample t test and multiple regression analysis to test hypotheses based on 487 responses from American participants. Four antecedents (i.e., CSR, CA, CR, and transparency) exhibited favorable effects on customer loyalty. Among these four factors, the positively perceived CSR initiatives had a greater impact on customer loyalty. In addition, according to our findings, female participants were more likely to have a positive perception of the four antecedents than males.

  13. Performance of fusion algorithms for computer-aided detection and classification of mines in very shallow water obtained from testing in navy Fleet Battle Exercise-Hotel 2000

    NASA Astrophysics Data System (ADS)

    Ciany, Charles M.; Zurawski, William; Kerfoot, Ian

    2001-10-01

    The performance of Computer Aided Detection/Computer Aided Classification (CAD/CAC) Fusion algorithms on side-scan sonar images was evaluated using data taken at the Navy's's Fleet Battle Exercise-Hotel held in Panama City, Florida, in August 2000. A 2-of-3 binary fusion algorithm is shown to provide robust performance. The algorithm accepts the classification decisions and associated contact locations form three different CAD/CAC algorithms, clusters the contacts based on Euclidian distance, and then declares a valid target when a clustered contact is declared by at least 2 of the 3 individual algorithms. This simple binary fusion provided a 96 percent probability of correct classification at a false alarm rate of 0.14 false alarms per image per side. The performance represented a 3.8:1 reduction in false alarms over the best performing single CAD/CAC algorithm, with no loss in probability of correct classification.

  14. Inelastic processes in Na+-Ne, Na+-Ar, Ne+-Na, and Ar+-Na collisions in the energy range 0.5-14 keV

    NASA Astrophysics Data System (ADS)

    Lomsadze, R. A.; Gochitashvili, M. R.; Kezerashvili, R. Ya.

    2015-12-01

    Absolute cross sections for charge-exchange, ionization, and excitation in Na+-Ne and Na+-Ar collisions were measured in the ion energy range 0.5 -10 keV using a refined version of a capacitor method and collision and optical spectroscopy methods simultaneously in the same experimental setup. Ionization cross sections for Ne+-Na and Ar+-Na collisions are measured at energies of 2 -14 keV using a crossed-beam spectroscopy method. The experimental data and the schematic correlation diagrams are used to analyze and determine the mechanisms for these processes. For the charge-exchange process in Na+-Ar collisions two nonadiabatic regions are revealed and mechanisms responsible for these regions are explained. Structural peculiarity on the excitation function for the resonance lines of argon atoms in Na+-Ar collisions are observed and the possible mechanisms of this phenomenon are explored. The measured ionization cross sections for Na+-Ne and Ne+-Na collisions in conjunction with the Landau-Zener formula are used to determine the coupling matrix element and transition probability in a region of pseudocrossing of the potential curves.

  15. Regulation of Na+ fluxes in plants

    PubMed Central

    Maathuis, Frans J. M.; Ahmad, Izhar; Patishtan, Juan

    2014-01-01

    When exposed to salt, every plant takes up Na+ from the environment. Once in the symplast, Na+ is distributed within cells and between different tissues and organs. There it can help to lower the cellular water potential but also exert potentially toxic effects. Control of Na+ fluxes is therefore crucial and indeed, research shows that the divergence between salt tolerant and salt sensitive plants is not due to a variation in transporter types but rather originates in the control of uptake and internal Na+ fluxes. A number of regulatory mechanisms has been identified based on signaling of Ca2+, cyclic nucleotides, reactive oxygen species, hormones, or on transcriptional and post translational changes of gene and protein expression. This review will give an overview of intra- and intercellular movement of Na+ in plants and will summarize our current ideas of how these fluxes are controlled and regulated in the early stages of salt stress. PMID:25278946

  16. High NA Nicrostepper Final Optical Design Report

    SciTech Connect

    Hudyma, R

    1999-09-24

    The development of a new EUV high NA small-field exposure tool has been proposed for obtaining mask defect printability data in a timeframe several years before beta-tools are available. The imaging system for this new Micro-Exposure Tool (MET), would have a numerical aperture (NA) of about 0.3, similar to the NA for a beta-tool, but substantially larger than the 0.10 NA for the Engineering Test Stand (ETS) and 0.088 NA for the existing 10x Microstepper. This memorandum discusses the development and summarizes the performance of the camera for the MET and includes a listing of the design prescription, detailed analysis of the distortion, and analysis demonstrating the capability to resolution 30 nm features under the conditions of partially coherent illumination.

  17. Negative electrodes for Na-ion batteries.

    PubMed

    Dahbi, Mouad; Yabuuchi, Naoaki; Kubota, Kei; Tokiwa, Kazuyasu; Komaba, Shinichi

    2014-08-01

    Research interest in Na-ion batteries has increased rapidly because of the environmental friendliness of sodium compared to lithium. Throughout this Perspective paper, we report and review recent scientific advances in the field of negative electrode materials used for Na-ion batteries. This paper sheds light on negative electrode materials for Na-ion batteries: carbonaceous materials, oxides/phosphates (as sodium insertion materials), sodium alloy/compounds and so on. These electrode materials have different reaction mechanisms for electrochemical sodiation/desodiation processes. Moreover, not only sodiation-active materials but also binders, current collectors, electrolytes and electrode/electrolyte interphase and its stabilization are essential for long cycle life Na-ion batteries. This paper also addresses the prospect of Na-ion batteries as low-cost and long-life batteries with relatively high-energy density as their potential competitive edge over the commercialized Li-ion batteries.

  18. Na-doped optical Germanium bulk crystals

    NASA Astrophysics Data System (ADS)

    Pekar, G. S.; Singaevsky, A. F.

    2012-09-01

    In an effort to develop a material for infrared (IR) optics with improved parameters, bulk crystals of optical germanium doped with Na have been first grown and studied. Single-crystalline and coarse-crystalline Ge:Na boules of different shapes and dimensions, up to 10 kg by weight, have been grown. Sodium was incorporated into the Ge crystal during the crystal growing from the melt. Despite the fact that Na contamination in the source material was not strictly controlled, the density of Na in the grown crystals determined by the neutron activation analysis as well as by the glow discharge mass spectrometry did not exceed 1015 cm-3. Just this value may be supposed to be close to the solubility limit of Na incorporated in Ge in the course of bulk crystal growth. A first demonstration of donor behavior of Na in bulk Ge crystals is made by means of a thermoelectric type of testing. An interstitial location of Na impurity has been verified by experiments on donor drift in the dc electric field. The crystals are grown with free electron density in the range from 5ṡ1013 to 4ṡ1014 cm-3 which is optimal for using Ge crystals as an optical material for fabricating passive elements of the IR technique. A comparison between the properties of Ge:Na crystals and Ge crystals doped with Sb, a conventional impurity in optical germanium, grown under the same technological conditions and from the same intrinsic Ge as a source material, revealed a number of advantages of Ge:Na crystals; among them, the higher transparency in the IR region, smaller radiation scattering and higher regular optical transmission, lower dislocation density, more uniform distribution of electrical and optical characteristics over the crystal volume, the identity of optical parameters in the single-crystalline, and coarse-crystalline boules. No degradation of optical elements fabricated from Ge:Na crystals was detected in the course of their commercial application, starting from 1998.

  19. Polarization dependence of Na/emph>+Na/emph> associative ionization revisited

    NASA Astrophysics Data System (ADS)

    Meijer, H. A. J.; Meulen, H. P. V. D.; Morgenstern, R.; Hertel, I. V.; Meyer, E.; Schmidt, H.; Witte, R.

    1986-02-01

    The dependence of the associative ionization process Na 3 2P3/2+Na 3 2P3/2-->Na2 ++e- on the polarization of the laser light used for Na excitation was independently investigated in Utrecht and Berlin. The purpose of this paper is to clarify discrepancies between earlier experimental results of Kircz, Morgenstern, and Nienhuis, on one hand, and Rothe, Theyunni, Reck, and Tung on the other hand. The new results confirm in general the data of Kircz, Morgenstern, and Nienhuis, and also indicate a dependence of the anisotropy ratios on the relative velocity of the interacting Na* atoms.

  20. The NA62 RICH detector

    SciTech Connect

    Cassese, A.

    2011-07-01

    The NA62 experiment is designed to measure the very rare kaon decay K{sup +} {yields} {pi}{sup +} at the CERN SPS with a 10% accuracy. The Standard Model prediction for the Branching Ratio is (8.5 {+-} 0.7) x 10{sup -11}. One of the challenging aspect of the experiment is the suppression of the K{sup +} {yields} {mu}{sup +} v{sub {mu}} background at the 10{sup -12} level. To satisfy this requirement a Ring Imaging Cherenkov Detector (RICH), able to separate {pi}{sup {+-}} from {mu}{sup {+-}} in the momentum range between 15 and 35 GeV/c, with a {mu}, rejection factor better than 10{sup -2}, is needed. The RICH must also have a time resolution of about 100 ps to disentangle accidental time associations of beam particles with pions. The RICH will have a very long focal length (17 m) and will be filled with Ne gas at atmospheric pressure. Two test beams were held at CERN in 2007 and 2009 with a RICH prototype. The results of the two test beams will be presented: the {mu}, mis-identification probability is found to be about 0.7% and the time resolution better than 100 ps in the whole momentum range. (authors)

  1. Na-site substitution effects on the thermoelectric properties of NaCo2O4

    NASA Astrophysics Data System (ADS)

    Kawata, T.; Iguchi, Y.; Itoh, T.; Takahata, K.; Terasaki, I.

    1999-10-01

    The resistivity and thermopower of Na1+xCo2O4 and Na1.1-xCaxCo2O4 are measured and analyzed. In Na1+xCo2O4, whereas the resistivity increases with x, the thermopower is nearly independent of x. This suggests that the excess Na is unlikely to supply carriers, and decreases effective conduction paths in the sample. In Na1.1-xCaxCo2O4, the resistivity and the thermopower increase with x, and the Ca2+ substitution for Na+ reduces the majority carriers in NaCo2O4. This means that they are holes, which is consistent with the positive sign of the thermopower. Strong correlation in this compound is evidenced by the peculiar temperature dependence of the resistivity.

  2. Extracellular Na+ levels regulate formation and activity of the NaX/alpha1-Na+/K+-ATPase complex in neuronal cells

    PubMed Central

    Berret, Emmanuelle; Smith, Pascal Y.; Henry, Mélaine; Soulet, Denis; Hébert, Sébastien S.; Toth, Katalin; Mouginot, Didier; Drolet, Guy

    2014-01-01

    MnPO neurons play a critical role in hydromineral homeostasis regulation by acting as sensors of extracellular sodium concentration ([Na+]out). The mechanism underlying Na+-sensing involves Na+-flow through the NaX channel, directly regulated by the Na+/K+-ATPase α1-isoform which controls Na+-influx by modulating channel permeability. Together, these two partners form a complex involved in the regulation of intracellular sodium ([Na+]in). Here we aim to determine whether environmental changes in Na+ could actively modulate the NaX/Na+/K+-ATPase complex activity. We investigated the complex activity using patch-clamp recordings from rat MnPO neurons and Neuro2a cells. When the rats were fed with a high-salt-diet, or the [Na+] in the culture medium was increased, the activity of the complex was up-regulated. In contrast, drop in environmental [Na+] decreased the activity of the complex. Interestingly under hypernatremic condition, the colocalization rate and protein level of both partners were up-regulated. Under hyponatremic condition, only NaX protein expression was increased and the level of NaX/Na+/K+-ATPase remained unaltered. This unbalance between NaX and Na+/K+-ATPase pump proportion would induce a bigger portion of Na+/K+-ATPase-control-free NaX channel. Thus, we suggest that hypernatremic environment increases NaX/Na+/K+-ATPase α1-isoform activity by increasing the number of both partners and their colocalization rate, whereas hyponatremic environment down-regulates complex activity via a decrease in the relative number of NaX channels controlled by the pump. PMID:25538563

  3. Gasotransmitters: novel regulators of epithelial na(+) transport?

    PubMed

    Althaus, Mike

    2012-01-01

    The vectorial transport of Na(+) across epithelia is crucial for the maintenance of Na(+) and water homeostasis in organs such as the kidneys, lung, or intestine. Dysregulated Na(+) transport processes are associated with various human diseases such as hypertension, the salt-wasting syndrome pseudohypoaldosteronism type 1, pulmonary edema, cystic fibrosis, or intestinal disorders, which indicate that a precise regulation of epithelial Na(+) transport is essential. Novel regulatory signaling molecules are gasotransmitters. There are currently three known gasotransmitters: nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H(2)S). These molecules are endogenously produced in mammalian cells by specific enzymes and have been shown to regulate various physiological processes. There is a growing body of evidence which indicates that gasotransmitters may also regulate Na(+) transport across epithelia. This review will summarize the available data concerning NO, CO, and H(2)S dependent regulation of epithelial Na(+) transport processes and will discuss whether or not these mediators can be considered as true physiological regulators of epithelial Na(+) transport biology.

  4. Myocardial Na,K-ATPase: Clinical aspects

    PubMed Central

    Kjeldsen, Keld

    2003-01-01

    The specific binding of digitalis glycosides to Na,K-ATPase is used as a tool for Na,K-ATPase quantification with high accuracy and precision. In myocardial biopsies from patients with heart failure, total Na,K-ATPase concentration is decreased by around 40%; a correlation exists between a decrease in heart function and a decrease in Na,K-ATPase concentration. During digitalization, around 30% of remaining pumps are occupied by digoxin. Myocardial Na,K-ATPase is also influenced by other drugs used for the treatment of heart failure. Thus, potassium loss during diuretic therapy has been found to reduce myocardial Na,K-ATPase, whereas angiotensin-converting enzyme inhibitors may stimulate Na,K pump activity. Furthermore, hyperaldosteronism induced by heart failure has been found to decrease Na,K-ATPase activity. Accordingly, treatment with the aldosterone antagonist, spironolactone, may also influence Na,K-ATPase activity. The importance of Na,K pump modulation with heart disease, inhibition in digitalization and other effects of medication should be considered in the context of sodium, potassium and calcium regulation. It is recommended that digoxin be administered to heart failure patients who, after institution of mortality-reducing therapy, still have heart failure symptoms, and that the therapy be continued if symptoms are revealed or reduced. Digitalis glycosides are the only safe inotropic drugs for oral use that improve hemodynamics in heart failure. An important aspect of myocardial Na,K pump affection in heart disease is its influence on extracellular potassium (Ke) homeostasis. Two important aspects should be considered: potassium handling among myocytes, and effects of potassium entering the extracellular space of the heart via the bloodstream. It should be noted that both of these aspects of Ke homeostasis are affected by regulatory aspects, eg, regulation of the Na,K pump by physiological and pathophysiological conditions, as well as by medical

  5. Characteristics and pharmacological regulation of epithelial Na+ channel (ENaC) and epithelial Na+ transport.

    PubMed

    Marunaka, Yoshinori

    2014-01-01

    Epithelial Na(+) transport participates in control of various body functions and conditions: e.g., homeostasis of body fluid content influencing blood pressure, control of amounts of fluids covering the apical surface of alveolar epithelial cells at appropriate levels for normal gas exchange, and prevention of bacterial/viral infection. Epithelial Na(+) transport via the transcellular pathway is mediated by the entry step of Na(+) across the apical membrane via Epithelial Na(+) Channel (ENaC) located at the apical membrane, and the extrusion step of Na(+) across the basolateral membrane via the Na(+),K(+)-ATPase located at the basolateral membrane. The rate-limiting step of the epithelial Na(+) transport via the transcellular pathway is generally recognized to be the entry step of Na(+) across the apical membrane via ENaC. Thus, up-/down-regulation of ENaC essentially participates in regulatory systems of blood pressure and normal gas exchange. Amount of ENaC-mediated Na(+) transport is determined by the number of ENaCs located at the apical membrane, activity (open probability) of individual ENaC located at the apical membrane, single channel conductance of ENaC located at the apical membrane, and driving force for the Na(+) entry via ENaCs across the apical membrane. In the present review article, I discuss the characteristics of ENaC and how these factors are regulated.

  6. Glutathionylation-Dependence of Na(+)-K(+)-Pump Currents Can Mimic Reduced Subsarcolemmal Na(+) Diffusion.

    PubMed

    Garcia, Alvaro; Liu, Chia-Chi; Cornelius, Flemming; Clarke, Ronald J; Rasmussen, Helge H

    2016-03-01

    The existence of a subsarcolemmal space with restricted diffusion for Na(+) in cardiac myocytes has been inferred from a transient peak electrogenic Na(+)-K(+) pump current beyond steady state on reexposure of myocytes to K(+) after a period of exposure to K(+)-free extracellular solution. The transient peak current is attributed to enhanced electrogenic pumping of Na(+) that accumulated in the diffusion-restricted space during pump inhibition in K(+)-free extracellular solution. However, there are no known physical barriers that account for such restricted Na(+) diffusion, and we examined if changes of activity of the Na(+)-K(+) pump itself cause the transient peak current. Reexposure to K(+) reproduced a transient current beyond steady state in voltage-clamped ventricular myocytes as reported by others. Persistence of it when the Na(+) concentration in patch pipette solutions perfusing the intracellular compartment was high and elimination of it with K(+)-free pipette solution could not be reconciled with restricted subsarcolemmal Na(+) diffusion. The pattern of the transient current early after pump activation was dependent on transmembrane Na(+)- and K(+) concentration gradients suggesting the currents were related to the conformational poise imposed on the pump. We examined if the currents might be accounted for by changes in glutathionylation of the β1 Na(+)-K(+) pump subunit, a reversible oxidative modification that inhibits the pump. Susceptibility of the β1 subunit to glutathionylation depends on the conformational poise of the Na(+)-K(+) pump, and glutathionylation with the pump stabilized in conformations equivalent to those expected to be imposed on voltage-clamped myocytes supported this hypothesis. So did elimination of the transient K(+)-induced peak Na(+)-K(+) pump current when we included glutaredoxin 1 in patch pipette solutions to reverse glutathionylation. We conclude that transient K(+)-induced peak Na(+)-K(+) pump current reflects the effect

  7. Dependence of Na-K pump current on internal Na+ in mammalian cardiac myocytes.

    PubMed

    Mogul, D J; Singer, D H; Ten Eick, R E

    1990-08-01

    Na-K pump current (Ipump) is a function of the intracellular Na+ concentration [( Na+]i). We examined the quantitative relationship between Ipump and [Na+]i in isolated guinea pig ventricular myocytes under steady-state conditions. [Na+]i was controlled and "clamped" at several selected concentrations using wide-tipped pipette microelectrodes, and membrane current was measured using the whole cell patch voltage-clamp technique. Ipump generated at a holding potential of -40 mV was determined by measuring the change in steady-state holding current before and during exposure to dihydroouabain (1 mM); Ipump was measured at 11 levels of [Na+]i ranging from 0 to 80 mM (n = 63) with only one measurement per cell and normalized to cell capacitance to account for differences between myocytes in sarcolemmal surface area. Ipump exhibited a nonlinear dependence on [Na+]i; a Hill analysis of the relationship yielded a half-maximal [Na+]i for pump stimulation of 43.2 mM and a Hill coefficient of 1.53. An alternative analysis of the experimental data was performed assuming that occupation of three internal binding sites by Na+ is required for enzyme turnover. Regression analysis gave the best fit when only two different binding affinities (KD) are postulated. The values are KD1 = 1 mM, KD2 = KD3 = 29 mM. From the analysis using the latter model, the level of [Na+]i at which Ipump saturated closely approximated the theoretical saturation level calculated from published estimates of pump turnover rate and density. The maximal sensitivity of the Na-K pump to changes in [Na+]i occurs when internal [Na+] is within the range for the normal resting physiological level. PMID:2167023

  8. [Na+/H+- and Na+/Na+-countertransport in human, rabbit, and rat erythrocytes: evidence for the existence of two independent ion-transporting systems].

    PubMed

    Orlov, S N; Kuznetsov, S R; Kolosova, I A; Makarov, V L

    1994-05-01

    The activity and regulatory features of the Na+/H(+)- and Na+/Na(+)-exchange were studied in human, rabbit and rat red blood cells. No basal activity of the Na+/H(+)-exchange (the amyloride-inhibited component of the 22Na+ influx) in erythrocytes of these species was observed. The rate of 22Na+ influx increased rapidly when the experiments were carried out on acid-loaded cells in an alkaline (pH0 = 8.0) incubation medium (delta mu H(+)-induced Na+/H(+)-exchange). The ratio of delta mu H(+)-induced Na+/H(+)-exchange activities in human, rabbit and rat red blood cells was 1.0 : 1.1 : 2.3, respectively, whereas that of the Na+/Na(+)-exchange activities (the phloretin-inhibited component of the 22Na+ influx) in erythrocytes of these species was 1.0 : 4.6 : 0.2. The osmotic shrinkage of rat and rabbit erythrocytes led to the stimulation of the Na+/H(+)- (but not Na+/Na+) exchange. Amyloride (1 mM) inhibited the shrinkage-induced 22Na+ entry as well as the delta mu H(+)-induced 22Na+ entry--by 95 and 10-20%, respectively. Heat treatment (10 min, 49-51 degrees C), disturbing the membrane cytoskeleton suppressed both the shrinkage-induced activation and the delta mu H(+)-induced activation of the Na+/H(+)-exchange. The data obtained indicate that the both transport systems are mediated by two distinct transport carriers. It may be suggested that the delta mu H(+)-induced Na+/H(+)-exchange, on the one hand, and the shrinkage-induced Na+/H(+)-exchange, on the other, are mediated by two different Na+/H(+)-exchanger subtypes. PMID:8043690

  9. Anamorphic high-NA EUV lithography optics

    NASA Astrophysics Data System (ADS)

    Migura, Sascha; Kneer, Bernhard; Neumann, Jens Timo; Kaiser, Winfried; van Schoot, Jan

    2015-09-01

    EUV lithography (EUVL) for a limit resolution below 8 nm requires the numerical aperture (NA) of the projection optics to be larger than 0.50. For such a high-NA optics a configuration of 4x magnification, full field size of 26 x 33 mm² and 6'' mask is not feasible anymore. The increased chief ray angle and higher NA at reticle lead to non-acceptable mask shadowing effects. These shadowing effects can only be controlled by increasing the magnification, hence reducing the system productivity or demanding larger mask sizes. We demonstrate that the best compromise in imaging, productivity and field split is a so-called anamorphic magnification and a half field of 26 x 16.5 mm² but utilizing existing 6'' mask infrastructure. We discuss the optical solutions for such anamorphic high-NA EUVL.

  10. Searches for New Physics at NA62

    NASA Astrophysics Data System (ADS)

    Palladino, Vito

    2011-10-01

    We present the latest NA62 results in the search for physics beyond Standard Model (SM). NA62 aims to have indirect evidences of new physics, measuring rare K decays. NA62 phase I took place in 2007 when we collected data in order to measure the ratio RK = Ke2/Kμ2 (were Kl2 means K → lνl) at few per mill level. A brief experimental layout description will be followed by analysis strategy and preliminary results. The last part of present paper will be devoted to the description of NA62 phase II, which has the main goal of measuring the ultra-rare K -> π ^ + ν bar ν decay Branching Ratio.

  11. Nanosegregation in Na2C60

    SciTech Connect

    Klupp, G.; Kamaras, K.; Matus, P.; Kiss, L.F.; Kovats, E.; Pekker, S.; Nemes, N.M.; Quintavalle, D.; Janossy, A.

    2005-09-27

    There is continuous interest in the nature of alkali metal fullerides containing C{sub 60}{sup 4-} and C{sub 60}{sup 2-}, because these compounds are believed to be nonmagnetic Mott-Jahn-Teller insulators. This idea could be verified in the case of A4C60, but Na2C60 is more controversial. By comparing the results of infrared spectroscopy and X-ray diffraction, we found that Na2C60 is segregated into 3-10 nm large regions. The two main phases of the material are insulating C60 and metallic Na3C60. We found by neutron scattering that the diffusion of sodium ions becomes faster on heating. Above 470 K Na2C60 is homogeneous and we show IR spectroscopic evidence of a Jahn-Teller distorted C{sub 60}{sup 2-} anion.

  12. Deliquescence of NaCl-NaNO3, KNO3-NaNO3, and NaCl-KNO3 Salt Mixtures From 90 to 120?C

    SciTech Connect

    Carroll, S A; Craig, L; Wolery, T J

    2004-10-20

    We conducted reversed deliquescence experiments in saturated NaCl-NaNO{sub 3}-H{sub 2}O, KNO{sub 3}-NaNO{sub 3}-H{sub 2}O, and NaCl-KNO{sub 3}-H{sub 2}O systems from 90 to 120 C as a function of relative humidity and solution composition. NaCl, NaNO{sub 3}, and KNO{sub 3} represent members of dust salt assemblages that are likely to deliquesce and form concentrated brines on high-level radioactive waste package surfaces in a repository environment at Yucca Mountain, NV, USA. Discrepancy between model prediction and experimental code can be as high as 8% for relative humidity and 50% for dissolved ion concentration. The discrepancy is attributed primarily to the use of 25 C models for Cl-NO{sub 3} and K-NO{sub 3} ion interactions in the current Yucca Mountain Project high-temperature Pitzer model to describe the non-ideal behavior of these highly concentrated solutions.

  13. Elastic Coulomb breakup of 34Na

    NASA Astrophysics Data System (ADS)

    Singh, G.; Shubhchintak, Chatterjee, R.

    2016-08-01

    Background: 34Na is conjectured to play an important role in the production of seed nuclei in the alternate r -process paths involving light neutron rich nuclei very near the β -stability line, and as such, it is important to know its ground state properties and structure to calculate rates of the reactions it might be involved in, in the stellar plasma. Found in the region of `island of inversion', its ground state might not be in agreement with normal shell model predictions. Purpose: The aim of this paper is to study the elastic Coulomb breakup of 34Na on 208Pb to give us a core of 33Na with a neutron and in the process we try and investigate the one neutron separation energy and the ground state configuration of 34Na. Method: A fully quantum mechanical Coulomb breakup theory within the architecture of post-form finite range distorted wave Born approximation extended to include the effects of deformation is used to research the elastic Coulomb breakup of 34Na on 208Pb at 100 MeV/u. The triple differential cross section calculated for the breakup is integrated over the desired components to find the total cross-section, momentum, and angular distributions as well as the average momenta, along with the energy-angular distributions. Results: The total one neutron removal cross section is calculated to test the possible ground state configurations of 34Na. The average momentum results along with energy-angular calculations indicate 34Na to have a halo structure. The parallel momentum distributions with narrow full widths at half-maxima signify the same. Conclusion: We have attempted to analyze the possible ground state configurations of 34Na and in congruity with the patterns in the `island of inversion' conclude that even without deformation, 34Na should be a neutron halo with a predominant contribution to its ground state most probably coming from 33Na(3 /2+)⊗ 2 p3 /2ν configuration. We also surmise that it would certainly be useful and rewarding to test our

  14. HCO3(-)-coupled Na+ influx is a major determinant of Na+ turnover and Na+/K+ pump activity in rat hepatocytes

    SciTech Connect

    Fitz, J.G.; Lidofsky, S.D.; Weisiger, R.A.; Xie, M.H.; Cochran, M.; Grotmol, T.; Scharschmidt, B.F. )

    1991-05-01

    Recent studies in hepatocytes indicate that Na(+)-coupled HCO3- transport contributes importantly to regulation of intracellular pH and membrane HCO3- transport. However, the direction of net coupled Na+ and HCO3- movement and the effect of HCO3- on Na+ turnover and Na+/K+ pump activity are not known. In these studies, the effect of HCO3- on Na+ influx and turnover were measured in primary rat hepatocyte cultures with 22Na+, and (Na+)i was measured in single hepatocytes using the Na(+)-sensitive fluorochrome SBFI. Na+/K+ pump activity was measured in intact perfused rat liver and hepatocyte monolayers as Na(+)-dependent or ouabain-suppressible 86Rb uptake, and was measured in single hepatocytes as the effect of transient pump inhibition by removal of extracellular K+ on membrane potential difference (PD) and (Na+)i. In hepatocyte monolayers, HCO3- increased 22Na+ entry and turnover rates by 50-65%, without measurably altering 22Na+ pool size or cell volume, and HCO3- also increased Na+/K+ pump activity by 70%. In single cells, exposure to HCO3- produced an abrupt and sustained rise in (Na+)i from approximately 8 to 12 mM. Na+/K+ pump activity assessed in single cells by PD excursions during transient K+ removal increased congruent to 2.5-fold in the presence of HCO3-, and the rise in (Na+)i produced by inhibition of the Na+/K+ pump was similarly increased congruent to 2.5-fold in the presence of HCO3-. In intact perfused rat liver, HCO3- increased both Na+/K+ pump activity and O2 consumption. These findings indicate that, in hepatocytes, net coupled Na+ and HCO3- movement is inward and represents a major determinant of Na+ influx and Na+/K+ pump activity. About half of hepatic Na+/K+ pump activity appears dedicated to recycling Na+ entering in conjunction with HCO3- to maintain (Na+)i within the physiologic range.

  15. Electrophysiological Determination of Submembrane Na(+) Concentration in Cardiac Myocytes.

    PubMed

    Hegyi, Bence; Bányász, Tamás; Shannon, Thomas R; Chen-Izu, Ye; Izu, Leighton T

    2016-09-20

    In the heart, Na(+) is a key modulator of the action potential, Ca(2+) homeostasis, energetics, and contractility. Because Na(+) currents and cotransport fluxes depend on the Na(+) concentration in the submembrane region, it is necessary to accurately estimate the submembrane Na(+) concentration ([Na(+)]sm). Current methods using Na(+)-sensitive fluorescent indicators or Na(+) -sensitive electrodes cannot measure [Na(+)]sm. However, electrophysiology methods are ideal for measuring [Na(+)]sm. In this article, we develop patch-clamp protocols and experimental conditions to determine the upper bound of [Na(+)]sm at the peak of action potential and its lower bound at the resting state. During the cardiac cycle, the value of [Na(+)]sm is constrained within these bounds. We conducted experiments in rabbit ventricular myocytes at body temperature and found that 1) at a low pacing frequency of 0.5 Hz, the upper and lower bounds converge at 9 mM, constraining the [Na(+)]sm value to ∼9 mM; 2) at 2 Hz pacing frequency, [Na(+)]sm is bounded between 9 mM at resting state and 11.5 mM; and 3) the cells can maintain [Na(+)]sm to the above values, despite changes in the pipette Na(+) concentration, showing autoregulation of Na(+) in beating cardiomyocytes. PMID:27653489

  16. Interaction of NaCl(g) and HCl(g) with condensed NA2SO4

    NASA Technical Reports Server (NTRS)

    Stearns, C. A.; Kohl, F. J.; Fryburg, G. C.; Miller, R. A.

    1977-01-01

    The interaction of Na2SO4(l) with NaCl(g), HCl(g) and H2O(g) was studied in atmospheric pressure flowing air and oxygen at Na2SO4(l) temperatures of 900 and 1000 C. Thermomicrogravimetric and high pressure mass spectrometric sampling techniques were used. Experimental results establish that previously reported enhanced rates of weight loss of Na2SO4(l) in the presence of NaCl(g) are due to the reaction: Na2SO4(c) + 2HCl(g) = 2NaCl(g) + SO2(g) + H2O(g) + 1/2O2(g) being driven to the right in flowing gas systems. The HCl(g) is the product of hydrolysis of NaCl caused by small but significant amounts of H2O(g) present in the system. Thermochemical calculations are used to show that even with sub-ppm levels of H2O(g) present, significant quantities of HCl(g) are produced.

  17. Direct Measurement of ^21Na+α Stellar Reaction

    NASA Astrophysics Data System (ADS)

    Binh Dam, Nguyen; Yamaguchi, H.; Wakabayashi, Y.; Hayakawa, S.; Hashimoto, T.; Kahl, D.; Kubono, S.; Le, H. K.; Nguyen, T. T.; Iwasa, N.; Kume, N.; Kato, S.; Teranishi, T.

    2009-10-01

    Nucleosynthesis of ^22Na is an interesting subject because of possible γ-ray observation and isotopic anomalies in presolar grain. ^22Na would have been mainly produced in the NeNa cycle. At high temperature conditions, ^21Na(α,p)^24Mg reaction could play a significant role to make flow from the NeNa cycle to the next MgAl cycle and beyond. Clearly, the ^21Na(α,p)^24Mg stellar reaction would bypass ^22Na, resulting in reduction of ^22Na production, therefore, it is strongly coupled to the Ne-E problem. It could be also important to understand the early stage of the rp-process. Experiment was performed using a 39 MeV ^21Na radioactive beam obtained by the CNS Radio Isotope Beam separator CRIB of the University of Tokyo. Both protons and alphas were measured from α+^21Na scattering with a thick ^4He gas target.

  18. Perceived discrimination and smoking among rural-to-urban migrant women working as restaurant/hotel workers and sex workers in China

    PubMed Central

    Shin, Sanghyuk S.; Wan, Xia; Wang, Qian; Raymond, H. Fisher; Liu, Huilin; Ding, Ding; Yang, Gonghuan; Novotny, Thomas E.

    2013-01-01

    Background Smoking may be a coping mechanism for psychosocial stress caused by discrimination. Methods We conducted a cross-sectional survey of rural-to-urban migrant women working as restaurant/hotel workers (RHWs) and those working as sex workers (FSWs) in 10 Chinese cities to investigate whether perceived discrimination is associated with smoking. We interviewed RHWs at medical examination clinics and FSWs at entertainment venues. Modified Poisson regression was used to estimate prevalence ratios. Results Of the 1696 RHWs and 532 FSWs enrolled, 155 (9.1%) and 63 (11.8%) reported perceived discrimination, respectively. Perceived discrimination was independently associated with ever tried smoking (prevalence ratio [PR], 1.71; 95% confidence interval [CI], 1.31–2.23) and current smoking (PR, 2.52; 95% CI, 1.32–4.79) among RHWs and ever tried smoking (PR, 1.36; 95% CI, 1.16–1.61) and current smoking (PR, 1.63; 95% CI, 1.28–2.06) among FSWs. Discussion Perceived discrimination is associated with higher prevalence of smoking among rural-to-urban migrant women in China. PMID:22389186

  19. Functional coupling of renal K+ and Na+ handling causes high blood pressure in Na+ replete mice

    PubMed Central

    Vitzthum, Helga; Seniuk, Anika; Schulte, Laura Helene; Müller, Maxie Luise; Hetz, Hannah; Ehmke, Heimo

    2014-01-01

    A network of kinases, including WNKs, SPAK and Sgk1, is critical for the independent regulation of K+ and Na+ transport in the distal nephron. Angiotensin II is thought to act as a key hormone in orchestrating these kinases to switch from K+ secretion during hyperkalaemia to Na+ reabsorption during intravascular volume depletion, thus keeping disturbances in electrolyte and blood pressure homeostasis at a minimum. It remains unclear, however, how K+ and Na+ transport are regulated during a high Na+ intake, which is associated with suppressed angiotensin II levels and a high distal tubular Na+ load. We therefore investigated the integrated blood pressure, renal, hormonal and gene and protein expression responses to large changes of K+ intake in Na+ replete mice. Both low and high K+ intake increased blood pressure and caused Na+ retention. Low K+ intake was accompanied by an upregulation of the sodium-chloride cotransporter (NCC) and its activating kinase SPAK, and inhibition of NCC normalized blood pressure. Renal responses were unaffected by angiotensin AT1 receptor antagonism, indicating that low K+ intake activates the distal nephron by an angiotensin-independent mode of action. High K+ intake was associated with elevated plasma aldosterone concentrations and an upregulation of the epithelial sodium channel (ENaC) and its activating kinase Sgk1. Surprisingly, high K+ intake increased blood pressure even during ENaC or mineralocorticoid receptor antagonism, suggesting the contribution of aldosterone-independent mechanisms. These findings show that in a Na+ replete state, changes in K+ intake induce specific molecular and functional adaptations in the distal nephron that cause a functional coupling of renal K+ and Na+ handling, resulting in Na+ retention and high blood pressure when K+ intake is either restricted or excessively increased. PMID:24396058

  20. NaCd excimer emission bands

    NASA Astrophysics Data System (ADS)

    Pichler, G.; Veža, D.; Fijan, D.

    1988-06-01

    The analysis of the visible spectrum of a high pressure sodium lamp filled with sodium, cadium and xenon revealed the existence of NaCd excimer spectral features. These are four red satellite bands at 691, 697, 709 and 726.5 nm and diffuse bands peaking at 479.1 and 484.3 nm. Both spectral phenomena are related to those found earlier for the NaHg system. An interpretation of the red satellite bands origin is given in terms of a qualitative model for the four lowest potential curves of the NaCd excimer. In this model the essential feature is the avoided crossing between B 2∑ 1/2 and A 2∏ 1/2 electronic states, which causes a complex structure of the satellite bands in the very far red wing of the sodium D lines broadened by cadmium.

  1. Targeting voltage gated sodium channels NaV1.7, Na V1.8, and Na V1.9 for treatment of pathological cough.

    PubMed

    Muroi, Yukiko; Undem, Bradley J

    2014-02-01

    Recent advances in our understanding of voltage-gated sodium channels (NaVs) lead to the rational hypothesis that drugs capable of selective blockade of NaV subtypes may be a safe and effective strategy for the treatment of unwanted cough. Among the nine NaV subtypes (NaV1.1-NaV1.9), the afferent nerves involved in initiating cough, in common with nociceptive neurons in the somatosensory system, express mainly NaV1.7, NaV1.8, and NaV1.9. Although knowledge about the effect of selectively blocking these channels on the cough reflex is limited, their biophysical properties indicate that each may contribute to the hypertussive and allotussive state that typifies subacute and chronic nonproductive cough.

  2. Concentration dependence of Li+/Na+ diffusion in manganese hexacyanoferrates

    NASA Astrophysics Data System (ADS)

    Takachi, Masamitsu; Fukuzumi, Yuya; Moritomo, Yutaka

    2016-06-01

    Manganese hexacyanoferrates (Mn-HCFs) with a jungle-gym-type structure are promising cathode materials for Li+/Na+ secondary batteries (LIBs/SIBs). Here, we investigated the diffusion constants D Li/D Na of Li+/Na+ against the Li+/Na+ concentration x Na/x Li and temperature (T) of A 1.32Mn[Fe(CN)6]0.833.6H2O (A = Li and Na). We evaluated the activation energy E\\text{a}\\text{Li}/E\\text{a}\\text{Na} of D Li/D Na against x Na/x Li. We found that E\\text{a}\\text{Na} steeply increases with x Na from 0.41 eV at x Na = 0.69 to 0.7 eV at 1.1. The increase in E\\text{a}\\text{Na} is ascribed to the occupancy effect of the Na+ site. The increase in E\\text{a}\\text{Li} is suppressed, probably because the number of Li+ sites is three times that of Na+ sites.

  3. Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state.

    PubMed

    Kanai, Ryuta; Ogawa, Haruo; Vilsen, Bente; Cornelius, Flemming; Toyoshima, Chikashi

    2013-10-10

    Na(+),K(+)-ATPase pumps three Na(+) ions out of cells in exchange for two K(+) taken up from the extracellular medium per ATP molecule hydrolysed, thereby establishing Na(+) and K(+) gradients across the membrane in all animal cells. These ion gradients are used in many fundamental processes, notably excitation of nerve cells. Here we describe 2.8 Å-resolution crystal structures of this ATPase from pig kidney with bound Na(+), ADP and aluminium fluoride, a stable phosphate analogue, with and without oligomycin that promotes Na(+) occlusion. These crystal structures represent a transition state preceding the phosphorylated intermediate (E1P) in which three Na(+) ions are occluded. Details of the Na(+)-binding sites show how this ATPase functions as a Na(+)-specific pump, rejecting K(+) and Ca(2+), even though its affinity for Na(+) is low (millimolar dissociation constant). A mechanism for sequential, cooperative Na(+) binding can now be formulated in atomic detail. PMID:24089211

  4. Na+/K+-ATPase: Activity and inhibition

    NASA Astrophysics Data System (ADS)

    Čolović, M.; Krstić, D.; Krinulović, K.; Momić, T.; Savić, J.; Vujačić, A.; Vasić, V.

    2009-09-01

    The aim of the study was to give an overview of the mechanism of inhibition of Na+/K+-ATPase activity induced by some specific and non specific inhibitors. For this purpose, the effects of some ouabain like compounds (digoxin, gitoxin), noble metals complexes ([PtCl2DMSO2], [AuCl4]-, [PdCl4]2-, [PdCl(dien)]+, [PdCl(Me4dien)]+), transition metal ions (Cu2+, Zn2+, Fe2+, Co2+), and heavy metal ions (Hg2+, Pb2+, Cd2+) on the activity of Na+/K+-ATPase from rat synaptic plasma membranes (SPM), porcine cerebral cortex and human erythrocytes were discussed.

  5. Na+ Inhibits the Epithelial Na+ Channel by Binding to a Site in an Extracellular Acidic Cleft*

    PubMed Central

    Kashlan, Ossama B.; Blobner, Brandon M.; Zuzek, Zachary; Tolino, Michael; Kleyman, Thomas R.

    2015-01-01

    The epithelial Na+ channel (ENaC) has a key role in the regulation of extracellular fluid volume and blood pressure. ENaC belongs to a family of ion channels that sense the external environment. These channels have large extracellular regions that are thought to interact with environmental cues, such as Na+, Cl−, protons, proteases, and shear stress, which modulate gating behavior. We sought to determine the molecular mechanism by which ENaC senses high external Na+ concentrations, resulting in an inhibition of channel activity. Both our structural model of an ENaC α subunit and the resolved structure of an acid-sensing ion channel (ASIC1) have conserved acidic pockets in the periphery of the extracellular region of the channel. We hypothesized that these acidic pockets host inhibitory allosteric Na+ binding sites. Through site-directed mutagenesis targeting the acidic pocket, we modified the inhibitory response to external Na+. Mutations at selected sites altered the cation inhibitory preference to favor Li+ or K+ rather than Na+. Channel activity was reduced in response to restraining movement within this region by cross-linking structures across the acidic pocket. Our results suggest that residues within the acidic pocket form an allosteric effector binding site for Na+. Our study supports the hypothesis that an acidic cleft is a key ligand binding locus for ENaC and perhaps other members of the ENaC/degenerin family. PMID:25389295

  6. Study on Na layer response to geomagnetic activities based on Odin/OSIRIS Na density data

    NASA Astrophysics Data System (ADS)

    Tsuda, Takuo; Nakamura, Takuji; Hedin, Jonas; Gumbel, Jorg; Hosokawa, Keisuke; Ejiri, Mitsumu K.; Nishiyama, Takanori; Takahashi, Toru

    2016-07-01

    The Na layer is normally distributed from 80 to 110 km, and the height range is corresponding to the ionospheric D and E region. In the polar region, the energetic particles precipitating from the magnetosphere can often penetrate into the E region and even into the D region. Thus, the influence of the energetic particles to the Na layer is one of interests in the aspect of the atmospheric composition change accompanied with the auroral activity. There are several previous studies in this issue. For example, recently, we have reported an initial result on a clear relationship between the electron density increase (due to the energetic particles) and the Na density decrease from observational data sets obtained by Na lidar, EISCAT VHF radar, and optical instruments at Tromsoe, Norway on 24-25 January 2012. However, all of the previous studies had been carried out based on case studies by ground-based lidar observations. In this study, we have performed, for the first time, statistical analysis using Na density data from 2004 to 2009 obtained with the Optical Spectrograph and InfraRed Imager System (OSIRIS) onboard Odin satellite. In the presentation, we will show relationship between the Na density and geomagnetic activities, and its latitudinal variation. Based on these results, the Na layer response to the energetic particles will be discussed.

  7. Na+ inhibits the epithelial Na+ channel by binding to a site in an extracellular acidic cleft.

    PubMed

    Kashlan, Ossama B; Blobner, Brandon M; Zuzek, Zachary; Tolino, Michael; Kleyman, Thomas R

    2015-01-01

    The epithelial Na(+) channel (ENaC) has a key role in the regulation of extracellular fluid volume and blood pressure. ENaC belongs to a family of ion channels that sense the external environment. These channels have large extracellular regions that are thought to interact with environmental cues, such as Na(+), Cl(-), protons, proteases, and shear stress, which modulate gating behavior. We sought to determine the molecular mechanism by which ENaC senses high external Na(+) concentrations, resulting in an inhibition of channel activity. Both our structural model of an ENaC α subunit and the resolved structure of an acid-sensing ion channel (ASIC1) have conserved acidic pockets in the periphery of the extracellular region of the channel. We hypothesized that these acidic pockets host inhibitory allosteric Na(+) binding sites. Through site-directed mutagenesis targeting the acidic pocket, we modified the inhibitory response to external Na(+). Mutations at selected sites altered the cation inhibitory preference to favor Li(+) or K(+) rather than Na(+). Channel activity was reduced in response to restraining movement within this region by cross-linking structures across the acidic pocket. Our results suggest that residues within the acidic pocket form an allosteric effector binding site for Na(+). Our study supports the hypothesis that an acidic cleft is a key ligand binding locus for ENaC and perhaps other members of the ENaC/degenerin family. PMID:25389295

  8. Role of the Na(+)-translocating NADH:quinone oxidoreductase in voltage generation and Na(+) extrusion in Vibrio cholerae.

    PubMed

    Vorburger, Thomas; Nedielkov, Ruslan; Brosig, Alexander; Bok, Eva; Schunke, Emina; Steffen, Wojtek; Mayer, Sonja; Götz, Friedrich; Möller, Heiko M; Steuber, Julia

    2016-04-01

    For Vibrio cholerae, the coordinated import and export of Na(+) is crucial for adaptation to habitats with different osmolarities. We investigated the Na(+)-extruding branch of the sodium cycle in this human pathogen by in vivo (23)Na-NMR spectroscopy. The Na(+) extrusion activity of cells was monitored after adding glucose which stimulated respiration via the Na(+)-translocating NADH:quinone oxidoreductase (Na(+)-NQR). In a V. cholerae deletion mutant devoid of the Na(+)-NQR encoding genes (nqrA-F), rates of respiratory Na(+) extrusion were decreased by a factor of four, but the cytoplasmic Na(+) concentration was essentially unchanged. Furthermore, the mutant was impaired in formation of transmembrane voltage (ΔΨ, inside negative) and did not grow under hypoosmotic conditions at pH8.2 or above. This growth defect could be complemented by transformation with the plasmid encoded nqr operon. In an alkaline environment, Na(+)/H(+) antiporters acidify the cytoplasm at the expense of the transmembrane voltage. It is proposed that, at alkaline pH and limiting Na(+) concentrations, the Na(+)-NQR is crucial for generation of a transmembrane voltage to drive the import of H(+) by electrogenic Na(+)/H(+) antiporters. Our study provides the basis to understand the role of the Na(+)-NQR in pathogenicity of V. cholerae and other pathogens relying on this primary Na(+) pump for respiration. PMID:26721205

  9. Mechanisms contributing to the cardiac inotropic effect of Na pump inhibition and reduction of extracellular Na

    PubMed Central

    1987-01-01

    Reduction of the transsarcolemmal [Na] gradient in rabbit cardiac muscle leads to an increase in the force of contraction. This has frequently been attributed to alteration of Ca movements via the sarcolemmal Na/Ca exchange system. However, the specific mechanisms that mediate the increased force at individual contractions have not been clearly established. In the present study, the [Na] gradient was decreased by reduction of extracellular [Na] or inhibition of the Na pump by either the cardioactive steroid acetylstrophanthidin or by reduction of extracellular [K]. Contractile performance and changes in extracellular Ca (sensed by double-barreled Ca-selective microelectrodes) were studied in order to elucidate the underlying basis for the increase in force. In the presence of agents that inhibit sarcoplasmic reticulum (SR) function (10 mM caffeine, 100-500 nM ryanodine), reduction of the [Na] gradient produced increases in contractile force similar to that observed in the absence of caffeine or ryanodine. It is concluded that an intact, functioning SR is not required for the inotropic effect of [Na] gradient reduction (at least in rabbit ventricle). However, this does not exclude a possible contribution of enhanced SR Ca release in the inotropic response to [Na] gradient reduction in the absence of caffeine or ryanodine. Acetylstrophanthidin (3-5 microM) usually leads to an increase in the magnitude of extracellular Ca depletions associated with individual contractions. However, acetylstrophanthidin can also increase extracellular Ca accumulation during the contraction, especially at potentiated contractions. This extracellular Ca accumulation can be suppressed by ryanodine and it is suggested that this apparent enhancement of Ca efflux is secondary to an enhanced release of Ca from the SR. Under conditions where Ca efflux during contractions is minimized (after a rest interval in the presence of ryanodine), acetylstrophanthidin increased both the rate and the

  10. Laser trapping of {sup 21}Na atoms

    SciTech Connect

    Lu, Zheng-Tian

    1994-09-01

    This thesis describes an experiment in which about four thousand radioactive {sup 21}Na (t{sub l/2} = 22 sec) atoms were trapped in a magneto-optical trap with laser beams. Trapped {sup 21}Na atoms can be used as a beta source in a precision measurement of the beta-asymmetry parameter of the decay of {sup 21}Na {yields} {sup 21}Ne + {Beta}{sup +} + v{sub e}, which is a promising way to search for an anomalous right-handed current coupling in charged weak interactions. Although the number o trapped atoms that we have achieved is still about two orders of magnitude lower than what is needed to conduct a measurement of the beta-asymmetry parameter at 1% of precision level, the result of this experiment proved the feasibility of trapping short-lived radioactive atoms. In this experiment, {sup 21}Na atoms were produced by bombarding {sup 24}Mg with protons of 25 MeV at the 88 in. Cyclotron of Lawrence Berkeley Laboratory. A few recently developed techniques of laser manipulation of neutral atoms were applied in this experiment. The {sup 21}Na atoms emerging from a heated oven were first transversely cooled. As a result, the on-axis atomic beam intensity was increased by a factor of 16. The atoms in the beam were then slowed down from thermal speed by applying Zeeman-tuned slowing technique, and subsequently loaded into a magneto-optical trap at the end of the slowing path. The last two chapters of this thesis present two studies on the magneto-optical trap of sodium atoms. In particular, the mechanisms of magneto-optical traps at various laser frequencies and the collisional loss mechanisms of these traps were examined.

  11. The solubility of Cr(OH){sub 3}(am) in concentrated NaOH and NaOH-NaNO{sub 3} solutions

    SciTech Connect

    Felmy, A.R.; Rai, D.; Fulton, R.W.

    1994-08-01

    Chromium is a major component of the Hanford waste tank sludges, and the presence of Cr in the sludges is a significant concern in the disposal of these sludges because Cr can interfere with the formation of waste glasses. One of the current pretreatment strategies for removing constituents that can interfere with glass formation, such as P and Cr, is to wash/dissolve the sludges in basic NaOH solutions. The solubility of Cr(OH){sub 3}(am) was measured in concentrated NaOH ranging in concentration from 0.1M to 6.0M and in NaOH-NaNO{sub 3} solutions with fixed NaOH concentration and variable NaNO{sub 3} concentration at room temperature (22--23 C). Equilibrium between solids and solutions was approached relatively slowly and required approximately 60--70 days before steady-state concentrations were reached. A thermodynamic model, based upon the Pitzer equations, was developed from the solubility data in NaOH, which includes only two aqueous Cr species (Cr(OH){sub 4}{sup {minus}} and NaCr(OH){sub 4}(aq)) and ion-interaction parameters for Na{sup +} with Cr(OH){sub 4}{sup {minus}}. This model was then tested in the mixed NaOH-NaNO{sub 3} solutions and found to be reliable.

  12. 24Mg( p, α)21Na reaction study for spectroscopy of 21Na

    NASA Astrophysics Data System (ADS)

    Cha, S. M.; Chae, K. Y.; Kim, A.; Lee, E. J.; Ahn, S.; Bardayan, D. W.; Chipps, K. A.; Cizewski, J. A.; Howard, M. E.; Manning, B.; O'Malley, P. D.; Ratkiewicz, A.; Strauss, S.; Kozub, R. L.; Matos, M.; Pain, S. D.; Pittman, S. T.; Smith, M. S.; Peters, W. A.

    2015-10-01

    The 24Mg( p, α)21Na reaction was measured at the Holifield Radioactive Ion Beam Facility at Oak Ridge National Laboratory in order to better constrain the spins and parities of the energy levels in 21Na for the astrophysically important 17F( α, p)20Ne reaction rate calculation. 31-MeV proton beams from the 25-MV tandem accelerator and enriched 24Mg solid targets were used. Recoiling 4He particles from the 24Mg( p, α)21Na reaction were detected by a highly segmented silicon detector array which measured the yields of 4He particles over a range of angles simultaneously. A new level at 6661 ± 5 keV was observed in the present work. The extracted angular distributions for the first four levels of 21Na and the results from distorted wave Born approximation (DWBA) calculations were compared to verify and extract the angular momentum transfer.

  13. Inhibition of Na(+)-independent H+ pump by Na(+)-induced changes in cell Ca2+

    PubMed Central

    1991-01-01

    Apical membrane H+ extrusion in the renal outer medullary collecting duct, inner stripe, is mediated by a Na(+)-independent H+ pump. To examine the regulation of this transporter, cell pH and cell Ca2+ were measured microfluorometrically in in vitro perfused tubules using 2',7'- bis(carboxyethyl)-5(6)-carboxyfluorescein and fura-2, respectively. Apical membrane H+ pump activity, assayed as cell pH recovery from a series of acid loads (NH3/NH+4 prepulse) in the total absence of ambient Na+, initially occurred at a slow rate (0.06 +/- 0.02 pH units/min), which was not sufficient to account for physiologic rates of H+ extrusion. Over 15-20 min after the initial acid load, the rate of Na(+)-independent cell pH recovery increased to 0.63 +/- 0.09 pH units/min, associated with a steady-state cell pH greater than the initial pre-acid load cell pH. This pattern suggested an initial suppression followed by a delayed activation of the apical membrane H+ pump. Replacement of peritubular Na+ with choline or N-methyl-D- glucosamine resulted in an initial spike increase in cell Ca2+ followed by a sustained increase in cell Ca2+. The initial rate of Na(+)- independent cell pH recovery could be increased by elimination of the Na+ removal-induced sustained cell Ca2+ elevation by: (a) performing studies in the presence of 135 mM peritubular Na+ (1 mM peritubular amiloride used to inhibit basolateral membrane Na+/H+ antiport); (b) clamping cell Ca2+ low with dimethyl-BAPTA, an intracellular Ca2+ chelating agent; or (c) removal of extracellular Ca2+. Cell acidification induced a spike increase in cell Ca2+. The late acceleration of Na(+)-independent cell pH recovery was independent of Na+ removal and of the method used to acidify the cell, but was eliminated by prevention of the cell Ca2+ spike and markedly delayed by the microfilament-disrupting agent, cytochalasin B. This study demonstrates that peritubular Na+ removal results in a sustained elevation in cell Ca2+, which inhibits

  14. A contrast-sensitive channelized-Hotelling observer to predict human performance in a detection task using lumpy backgrounds and Gaussian signals

    NASA Astrophysics Data System (ADS)

    Park, Subok; Badano, Aldo; Gallas, Brandon D.; Myers, Kyle J.

    2007-03-01

    Previously, a non-prewhitening matched filter (NPWMF) incorporating a model for the contrast sensitivity of the human visual system was introduced for modeling human performance in detection tasks with different viewing angles and white-noise backgrounds by Badano et al. But NPWMF observers do not perform well detection tasks involving complex backgrounds since they do not account for random backgrounds. A channelized-Hotelling observer (CHO) using difference-of-Gaussians (DOG) channels has been shown to track human performance well in detection tasks using lumpy backgrounds. In this work, a CHO with DOG channels, incorporating the model of the human contrast sensitivity, was developed similarly. We call this new observer a contrast-sensitive CHO (CS-CHO). The Barten model was the basis of our human contrast sensitivity model. A scalar was multiplied to the Barten model and varied to control the thresholding effect of the contrast sensitivity on luminance-valued images and hence the performance-prediction ability of the CS-CHO. The performance of the CS-CHO was compared to the average human performance from the psychophysical study by Park et al., where the task was to detect a known Gaussian signal in non-Gaussian distributed lumpy backgrounds. Six different signal-intensity values were used in this study. We chose the free parameter of our model to match the mean human performance in the detection experiment at the strongest signal intensity. Then we compared the model to the human at five different signal-intensity values in order to see if the performance of the CS-CHO matched human performance. Our results indicate that the CS-CHO with the chosen scalar for the contrast sensitivity predicts human performance closely as a function of signal intensity.

  15. Secondhand smoke exposure and risk following the Irish smoking ban: an assessment of salivary cotinine concentrations in hotel workers and air nicotine levels in bars

    PubMed Central

    Mulcahy, M; Evans, D; Hammond, S; Repace, J; Byrne, M

    2005-01-01

    Objective: To investigate whether the Irish smoking ban has had an impact on secondhand smoke (SHS) exposures for hospitality workers. Design, setting, and participants: Before and after the smoking ban a cohort of workers (n = 35) from a sample of city hotels (n = 15) were tested for saliva cotinine concentrations and completed questionnaires. Additionally, a random sample (n = 20) of city centre bars stratified by size (range 400–5000 square feet), were tested for air nicotine concentrations using passive samplers before and after the ban. Main outcome measures: Salivary cotinine concentrations (ng/ml), duration of self reported exposures to secondhand smoke, air nicotine (µg/cubic metre). Results: Cotinine concentrations reduced by 69%, from 1.6 ng/ml to 0.5 ng/ml median (SD 1.29; p < 0.005). Overall 74% of subjects experienced decreases (range 16–99%), with 60% showing a halving of exposure levels at follow up. Self reported exposure to SHS at work showed a significant reduction from a median 30 hours a week to zero (p < 0.001). There was an 83% reduction in air nicotine concentrations from median 35.5 µg/m3 to 5.95 µg/m3 (p < 0.001). At baseline, three bars (16%) were below the 6.8 µg/m3 air nicotine significant risk level for lung cancer alone; at follow up this increased to 10 (53%). Conclusions: Passive smoking and associated risks were significantly reduced but not totally eliminated. Exposure to SHS is still possible for those working where smoking is still allowed and those working where smoke may migrate from outdoor areas. Further research is required to assess the true extent and magnitude of these exposures. PMID:16319361

  16. Task-based detectability comparison of exponential transformation of free-response operating characteristic (EFROC) curve and channelized Hotelling observer (CHO)

    NASA Astrophysics Data System (ADS)

    Khobragade, P.; Fan, Jiahua; Rupcich, Franco; Crotty, Dominic J.; Gilat Schmidt, Taly

    2016-03-01

    This study quantitatively evaluated the performance of the exponential transformation of the free-response operating characteristic curve (EFROC) metric, with the Channelized Hotelling Observer (CHO) as a reference. The CHO has been used for image quality assessment of reconstruction algorithms and imaging systems and often it is applied to study the signal-location-known cases. The CHO also requires a large set of images to estimate the covariance matrix. In terms of clinical applications, this assumption and requirement may be unrealistic. The newly developed location-unknown EFROC detectability metric is estimated from the confidence scores reported by a model observer. Unlike the CHO, EFROC does not require a channelization step and is a non-parametric detectability metric. There are few quantitative studies available on application of the EFROC metric, most of which are based on simulation data. This study investigated the EFROC metric using experimental CT data. A phantom with four low contrast objects: 3mm (14 HU), 5mm (7HU), 7mm (5 HU) and 10 mm (3 HU) was scanned at dose levels ranging from 25 mAs to 270 mAs and reconstructed using filtered backprojection. The area under the curve values for CHO (AUC) and EFROC (AFE) were plotted with respect to different dose levels. The number of images required to estimate the non-parametric AFE metric was calculated for varying tasks and found to be less than the number of images required for parametric CHO estimation. The AFE metric was found to be more sensitive to changes in dose than the CHO metric. This increased sensitivity and the assumption of unknown signal location may be useful for investigating and optimizing CT imaging methods. Future work is required to validate the AFE metric against human observers.

  17. A Selective Na(+) Aptamer Dissected by Sensitized Tb(3+) Luminescence.

    PubMed

    Zhou, Wenhu; Ding, Jinsong; Liu, Juewen

    2016-08-17

    A previous study of two RNA-cleaving DNAzymes, NaA43 and Ce13d, revealed the possibility of a common Na(+) aptamer motif. Because Na(+) binding to DNA is a fundamental biochemical problem, the interaction between Ce13d and Na(+) was studied in detail by using sensitized Tb(3+) luminescence spectroscopy. Na(+) displaces Tb(3+) from the DNAzyme, and thus quenches the emission from Tb(3+) . The overall requirement for Na(+) binding includes the hairpin and the highly conserved 16-nucleotide loop in the enzyme strand, along with a few unpaired nucleotides in the substrate. Mutation studies indicate good correlation between Na(+) binding and cleavage activity, thus suggesting a critical role of Na(+) binding for the enzyme activity. Ce13d displayed a Kd of ∼20 mm with Na(+) (other monovalent cations: 40-60 mm). The Kd values for other metal ions are mainly due to non-specific competition. With a single nucleotide mutation, the specific Na(+) binding was lost. Another mutant improved Kd to 8 mm with Na(+) . This study has demonstrated a Na(+) aptamer with important biological implications and analytical applications. It has also defined the structural requirements for Na(+) binding and produced an improved mutant. PMID:27238890

  18. Intracellular Na+ regulation of Na+ pump sites in cultured vascular smooth muscle cells

    SciTech Connect

    Allen, J.C.; Navran, S.S.; Seidel, C.L.; Dennison, D.K.; Amann, J.M.; Jemelka, S.K.

    1989-04-01

    Enzymatically dispersed cells from canine saphenous vein and femoral artery were grown in fetal calf serum and studied at day 0 (freshly dispersed) through confluence in primary culture. Intracellular Na levels (Nai), but not intracellular K (Ki), were increased after 24 h in culture and then decreased to a steady state by 4 days. Na+ pump site number (( /sup 3/H) ouabain binding) increased through day 3 and remained elevated. Nai was still elevated at 2 days when the Na+ pump site number began to increase. Total pump turnover (maximum ouabain-inhibited /sup 86/Rb uptake) reflected the increase in Na+ pump site number. These key events precede the observed increases in both protein production and cellular proliferation. If the same cells are maintained in defined medium, without fetal calf serum, Nai, Ki, and the number of (/sup 3/H)ouabain binding sites do not change with time. These data are consistent with the suggestion that the initial mitogenic response of vascular smooth muscle cells to fetal calf serum involves an increased Na+ influx, and a Nai accumulation, caused by low Na+ pump density. The synthesis of new pump sites effects a decrease in the accumulated Nai, which may be related to cell proliferation.

  19. Na/beta-alumina/NaAlCl4, Cl2/C circulating cell

    NASA Technical Reports Server (NTRS)

    Cherng, Jing-Yih; Bennion, Douglas N.

    1987-01-01

    A study was made of a high specific energy battery based on a sodium negative electrode and a chlorine positive electrode with molten AlCl3-NaCl electrolyte and a solid beta alumina separator. The basic performance of a Na beta-alumina NaAlCl4, Cl2/C circulating cell at 200 C was demonstrated. This cell can be started at 150 C. The use of melting sodium chloroaluminate electrolyte overcomes some of the material problems associated with the high working temperatures of present molten salt systems, such as Na/S and LiAl/FeS, and retains the advantages of high energy density and relatively efficient electrode processes. Preliminary investigations were conducted on a sodium-chlorine static cell, material compability, electrode design, wetting, and theoretical calculations to assure a better chance of success before assembling a Na/Cl2 circulating cell. Mathematical models provide a theoretical explanation for the performance of the NaCl2 battery. The results of mathematical models match the experimental results very well. According to the result of the mathematical modeling, an output at 180 mA/sq cm and 3.2 V can be obtained with optimized cell design.

  20. Final-state symmetry of Na 1s core-shell excitons in NaCl and NaF

    SciTech Connect

    Nagle, K.P.; Seidler, G.T.; Shirley, E.L.; Fister, T.T.; Bradley, J.A.; Brown, F.C.

    2009-08-13

    We report measurements of the Na 1s contribution to the nonresonant inelastic x-ray scattering (NRIXS) from NaCl and NaF. Prior x-ray absorption studies have observed two pre-edge excitons in both materials. The momentum-transfer dependence (q dependence) of the measured NRIXS cross section and of real-space full multiple scattering and Bethe-Salpeter calculations determine that the higher-energy core excitons are s type for each material. The lower-energy core excitons contribute at most weakly to the NRIXS signal and we propose that these may be surface core excitons, as have been observed in several other alkali halides. The analysis of the orbital angular momentum of these features leads to a discussion of the limited sensitivity of NRIXS measurements to d-type final states when investigating 1s initial states. In this case the s- and p-type final density of states can be characterized by measurements at a small number of momentum transfers. This is in contrast to the case of more complex initial states for which measurements at a large number of momentum transfers are needed to separate the rich admixture of accessible and contributing final-state symmetries.

  1. Final-state symmetry of Na 1s core-shell excitons in NaCl and NaF.

    SciTech Connect

    Nagle, K. P.; Seidler, G. T.; Shirley, E. L.; Fister, T. T.; Bradley, J. A.; Brown, F. C.; Materials Science Division; Univ. of Washington; NIST

    2009-01-01

    We report measurements of the Na 1s contribution to the nonresonant inelastic x-ray scattering (NRIXS) from NaCl and NaF. Prior x-ray absorption studies have observed two pre-edge excitons in both materials. The momentum-transfer dependence (q dependence) of the measured NRIXS cross section and of real-space full multiple scattering and Bethe-Salpeter calculations determine that the higher-energy core excitons are s type for each material. The lower-energy core excitons contribute at most weakly to the NRIXS signal and we propose that these may be surface core excitons, as have been observed in several other alkali halides. The analysis of the orbital angular momentum of these features leads to a discussion of the limited sensitivity of NRIXS measurements to d-type final states when investigating 1s initial states. In this case the s- and p-type final density of states can be characterized by measurements at a small number of momentum transfers. This is in contrast to the case of more complex initial states for which measurements at a large number of momentum transfers are needed to separate the rich admixture of accessible and contributing final-state symmetries.

  2. Kan Na! Authentic Chinese Reading. Lessons for Intermediate to Advanced Self-Study. [CD-ROM].

    ERIC Educational Resources Information Center

    Fleming, Stephen; Hiple, David; Ning, Cynthia

    This compact disc offers several lessons in Chinese, including a photo feature from a Chinese newspaper, the service directory from a Chinese hotel room, a pamphlet for travelers from Taiwan, a family letter, an introduction to Chinese cuisine, an article about a hijacking, a letter of agreement between institutions, an odyssey of a teenaged boy,…

  3. Rescue of Na+ affinity in aspartate 928 mutants of Na+,K+-ATPase by secondary mutation of glutamate 314.

    PubMed

    Holm, Rikke; Einholm, Anja P; Andersen, Jens P; Vilsen, Bente

    2015-04-10

    The Na(+),K(+)-ATPase binds Na(+) at three transport sites denoted I, II, and III, of which site III is Na(+)-specific and suggested to be the first occupied in the cooperative binding process activating phosphorylation from ATP. Here we demonstrate that the asparagine substitution of the aspartate associated with site III found in patients with rapid-onset dystonia parkinsonism or alternating hemiplegia of childhood causes a dramatic reduction of Na(+) affinity in the α1-, α2-, and α3-isoforms of Na(+),K(+)-ATPase, whereas other substitutions of this aspartate are much less disruptive. This is likely due to interference by the amide function of the asparagine side chain with Na(+)-coordinating residues in site III. Remarkably, the Na(+) affinity of site III aspartate to asparagine and alanine mutants is rescued by second-site mutation of a glutamate in the extracellular part of the fourth transmembrane helix, distant to site III. This gain-of-function mutation works without recovery of the lost cooperativity and selectivity of Na(+) binding and does not affect the E1-E2 conformational equilibrium or the maximum phosphorylation rate. Hence, the rescue of Na(+) affinity is likely intrinsic to the Na(+) binding pocket, and the underlying mechanism could be a tightening of Na(+) binding at Na(+) site II, possibly via movement of transmembrane helix four. The second-site mutation also improves Na(+),K(+) pump function in intact cells. Rescue of Na(+) affinity and Na(+) and K(+) transport by second-site mutation is unique in the history of Na(+),K(+)-ATPase and points to new possibilities for treatment of neurological patients carrying Na(+),K(+)-ATPase mutations.

  4. Cardiac Na Channels: Structure to Function.

    PubMed

    DeMarco, K R; Clancy, C E

    2016-01-01

    Heart rhythms arise from electrical activity generated by precisely timed opening and closing of ion channels in individual cardiac myocytes. Opening of the primary cardiac voltage-gated sodium (NaV1.5) channel initiates cellular depolarization and the propagation of an electrical action potential that promotes coordinated contraction of the heart. The regularity of these contractile waves is critically important since it drives the primary function of the heart: to act as a pump that delivers blood to the brain and vital organs. When electrical activity goes awry during a cardiac arrhythmia, the pump does not function, the brain does not receive oxygenated blood, and death ensues. Perturbations to NaV1.5 may alter the structure, and hence the function, of the ion channel and are associated downstream with a wide variety of cardiac conduction pathologies, such as arrhythmias. PMID:27586288

  5. Optically pumped Na/sub 2/ laser

    SciTech Connect

    Kanorskii, S.I.; Kaslin, V.M.; Yakushev, O.F.

    1980-10-01

    A pulsed copper vapor laser emitting the 578.2 nm line was used as the pump source in achieving stimulated emission as a result of the electronic A/sup 1/..sigma../sup +//sub u/ to X/sup 1/..sigma../sup +//sub g/ transitions in the Na/sub 2/ molecule in the spectral range 0.765 to 0.804 ..mu... The average power of all the emission lines was 10 mW when the pulsed pump power was 150 W and the efficiency of conversion of the optical pump energy was about 3%. The pulse repetition frequency was 3.3 kHz. Violet diffuse radiation of the Na/sub 2/ molecules, generated by pumping with the copper vapor laser, was observed. The superradiance regime was found for some of the lines.

  6. Igneous origin for the NA in the cloud of Io

    NASA Astrophysics Data System (ADS)

    Johnson, M. L.; Burnett, D. S.

    1990-06-01

    Mixtures of sulfur and Na-bearing silicates were heated in evacuated silica glass capsules to temperatures between 600 C and 950 C. At or above 850 C, Na-silicate glass reacts with elemental S to form a (Na, K) sulfide. Mobilization of this phase may account for the presence of Na and K on the surface of Io, and hence in the material sputtered onto the Jovian magnetosphere.

  7. Sources of Na for the Io atmosphere

    NASA Technical Reports Server (NTRS)

    Burnett, D. S.; Ellis, Susan B.; Rice, A.; Epstein, S.

    1993-01-01

    The physics and geology of Io have been extensively studied, but there has been little discussion of the chemistry. Relatively little is known about Io chemistry, but there are constraints. Further, it will be a long time before improvements will result from direct observation, given the severe difficulties with the Galileo mission. Via laboratory simulation experiments, plausible thermochemical and photochemical processes which determine the nature and amounts of surface constituents of Io are explored. The well-known density of Io shows that the planet overall is rocky. Because the orbit of Io is well within the magnetosphere of Jupiter and because Io only has a thin, transient SO2 atmosphere, the surface is continually sputtered with magnetospheric ions. Complex processes ionize and accelerate the Io surface atoms to keV and MeV energies. Remarkably, only S, O, and Na ions were found by Voyager. Sputtering also produces an atomic cloud of Na and S (O not observable) with a trace of K. Both gaseous and solid SO2 are known from spectroscopic studies. A trace of H2S and possibly CO2 are present. Geologic features are interpreted in terms of elemental S, but there is no direct evidence for this constituent. We thus have a rocky planet which does not have rocks on the surface. Our general goal is to understand the cycling of Na, S, and O through the crust and atmosphere on present-day Io and to understand how Io evolved to this state. A specific objective was to determine the phases on the surface which are the source of the Na in the atmosphere of Io.

  8. Hybrid thermoelastic properties of NaCl

    NASA Astrophysics Data System (ADS)

    Wentzcovitch, R. M.; Marcondes, M. L.; Shukla, G.

    2015-12-01

    Despite the importance of thermoelastic properties of minerals in geophysics, their measurements at high pressures and temperatures are limited. Thus, ab initio calculations are an essential tool for predicting these properties at extreme conditions. Owing to the approximate description of the exchange-correlation energy and to approximations used in calculations of vibrational effects, these methods produce systematic deviations. Hybrid schemes combining experimental data and theoretical results have emerged as a way to reconcile available information and offer more reliable predictions at experimentally inaccessible thermodynamics conditions. Here we introduce a hybrid scheme to reconcile calculated and measured elastic coefficients and apply it to rock-salt-type NaCl, a challenging material to describe by ab initio and an important mineral in the context of oil/gas exploration. The approach is predictive within the temperature range of validity of the quasiharmonic approximation and results are used to generate velocities of NaCl at desirable geological conditions. [1] Marcondes, M. L. & Wentzcovitch, R.M. (2015). Hybrid ab-initio/experimental thermal equations of state: application to the NaCl pressure scale, J. Appl. Phys. 117:215902.

  9. Na+ transport in Acetabularia bypasses conductance of plasmalemma.

    PubMed

    Amtmann, A; Gradmann, D

    1994-04-01

    Na(+)-selective microelectrodes with the sensor ETH 227 have been used to measure the cytoplasmic Na+ concentration, [Na+]c, in Acetabularia. In the steady-state, [Na+]c is about 60 mM (external 460 mM). Steps in external Na+ concentration, [Na+]o, cause biexponential relaxations of [Na+]c which have formally been described by a serial three-compartment model (outside<==>compartment 1<==>compartment 2). From the initial slopes (some mMsec-1) net uptake and release of about 3 mumolm-2sec-1 Na+ are determined. Surprisingly, but consistent with previous tracer flux measurements (Mummert, H., Gradmann, D. 1991. J. Membrane Biol, 124:255-263), these Na+ fluxes are not accompanied by corresponding changes of the transplasmalemma voltage. [Na+]c is neither affected by the membrane voltage, nor by electrochemical gradients of H+ or Cl- across the plasmalemma, nor by cytoplasmic ATP. The results suggest a powerful vesicular transport system for ions which bypasses the conductance of the plasmalemma. In addition, transient increases of [Na+]c have been observed to take place facultatively during action potentials. The exponential distribution of the amplitudes of these transients (many small and few large peaks) points to local events in the more ore less close vicinity of the Na+ recording electrode. These events are suggested to consist of disruption of endoplasmic vesicles due to a loss of pressure in the cytoplasm.

  10. Genome Sequences of Cupriavidus metallidurans Strains NA1, NA4, and NE12, Isolated from Space Equipment.

    PubMed

    Monsieurs, Pieter; Mijnendonckx, Kristel; Provoost, Ann; Venkateswaran, Kasthuri; Ott, C Mark; Leys, Natalie; Van Houdt, Rob

    2014-01-01

    Cupriavidus metallidurans NA1, NA4, and NE12 were isolated from space and spacecraft-associated environments. Here, we report their draft genome sequences with the aim of gaining insight into their potential to adapt to these environments.

  11. Effects of altering the ATP/ADP ratio on pump-mediated Na/K and Na/Na exchanges in resealed human red blood cell ghosts

    PubMed Central

    1986-01-01

    Resealed human red blood cell ghosts were prepared to contain a range of ADP concentrations at fixed ATP concentrations and vice versa. ATP/ADP ratios ranging from approximately 0.2 to 50 were set and maintained (for up to 45 min) in this system. ATP and ADP concentrations were controlled by the addition of either a phosphoarginine- or phosphocreatine-based regenerating system. Ouabain- sensitive unidirectional Na efflux was determined in the presence and absence of 15 mM external K as a function of the nucleotide composition. Na/K exchange was found to increase to saturation with ATP (K 1/2 approximately equal to 250 microM), whereas Na/Na exchange (measured in K-free solutions) was a saturating function of ADP (K 1/2 approximately equal to 350 microM). The elevation of ATP from approximately 100 to 1,800 microM did not appreciably affect Na/Na exchange. In the presence of external Na and a saturating concentration of external K, increasing the ADP concentration at constant ATP was found to decrease ouabain-sensitive Na/K exchange. The decreased Na/K exchange that still remained when the ADP/ATP ratio was high was stimulated by removal of external Na. Assuming that under normal substrate conditions the reaction cycle of the Na/K pump is rate- limited by the conformational change associated with the release of occluded K [E2 X (K) X ATP----E1 X ATP + K], increasing ADP inhibits the rate of these transformations by competition with ATP for the E2(K) form. A less likely alternative is that inhibition is due to competition with ATP at the high-affinity site (E1). The acceleration of the Na/K pump that occurs upon removing external Na at high levels of ADP evidently results from a shift in the forward direction of the transformation of the intermediates involved with the release of occluded Na from E1P X (Na). Thus, the nucleotide composition and the Na gradient can modulate the rate at which the Na/K pump operates. PMID:3950576

  12. Zero-gravity growth of NaF-NaCl eutectics in the NASA Skylab program

    NASA Technical Reports Server (NTRS)

    Yue, A. S.; Allen, F. G.; Yu, J. G.

    1976-01-01

    Continuous and discontinuous NaF fibers, embedded in a NaCl matrix, were produced in space and on earth. The production of continuous fibers in a eutectic mixture is attributed to the absence of convection current in the liquid during solidification in space. Image transmission and optical transmittance measurements of transverse sections of the space-grown and earth-grown ingots were made with a light microscope and a spectrometer. It is shown that better optical properties were obtained from samples grown in space. This was attributed to a better alignment of NaF fibers along the ingot axis. A new concept is advanced to explain the phenomenon of transmittance versus far infrared wavelength of the directionally solidified NaCl-NaF eutectic in terms of the two-dimensional Bragg Scattering and the polarization effect of Rayleigh scattering. This concept can be applied to other eutectic systems as long as the index of refraction of the matrix over a range of wavelengths is known. Experimental data are in agreement with the theoretical prediction.

  13. pNaKtide inhibits Na/K-ATPase reactive oxygen species amplification and attenuates adipogenesis

    PubMed Central

    Sodhi, Komal; Maxwell, Kyle; Yan, Yanling; Liu, Jiang; Chaudhry, Muhammad A.; Getty, Morghan; Xie, Zijian; Abraham, Nader G.; Shapiro, Joseph I.

    2015-01-01

    Obesity has become a worldwide epidemic and is a major risk factor for metabolic syndrome. Oxidative stress is known to play a role in the generation and maintenance of an obesity phenotype in both isolated adipocytes and intact animals. Because we had identified that the Na/K-ATPase can amplify oxidant signaling, we speculated that a peptide designed to inhibit this pathway, pNaKtide, might ameliorate an obesity phenotype. To test this hypothesis, we first performed studies in isolated murine preadipocytes (3T3L1 cells) and found that pNaKtide attenuated oxidant stress and lipid accumulation in a dose-dependent manner. Complementary experiments in C57Bl6 mice fed a high-fat diet corroborated our in vitro observations. Administration of pNaKtide in these mice reduced body weight gain, restored systemic redox and inflammatory milieu, and, crucially, improved insulin sensitivity. Thus, we propose that inhibition of Na/K-ATPase amplification of oxidative stress may ultimately be a novel way to combat obesity, insulin resistance, and metabolic syndrome. PMID:26601314

  14. Plant Defensins NaD1 and NaD2 Induce Different Stress Response Pathways in Fungi.

    PubMed

    Dracatos, Peter M; Payne, Jennifer; Di Pietro, Antonio; Anderson, Marilyn A; Plummer, Kim M

    2016-09-03

    Nicotiana alata defensins 1 and 2 (NaD1 and NaD2) are plant defensins from the ornamental tobacco that have antifungal activity against a variety of fungal pathogens. Some plant defensins interact with fungal cell wall O-glycosylated proteins. Therefore, we investigated if this was the case for NaD1 and NaD2, by assessing the sensitivity of the three Aspergillus nidulans (An) O-mannosyltransferase (pmt) knockout (KO) mutants (An∆pmtA, An∆pmtB, and An∆pmtC). An∆pmtA was resistant to both defensins, while An∆pmtC was resistant to NaD2 only, suggesting NaD1 and NaD2 are unlikely to have a general interaction with O-linked side chains. Further evidence of this difference in the antifungal mechanism was provided by the dissimilarity of the NaD1 and NaD2 sensitivities of the Fusarium oxysporum f. sp. lycopersici (Fol) signalling knockout mutants from the cell wall integrity (CWI) and high osmolarity glycerol (HOG) mitogen-activated protein kinase (MAPK) pathways. HOG pathway mutants were sensitive to both NaD1 and NaD2, while CWI pathway mutants only displayed sensitivity to NaD2.

  15. Plant Defensins NaD1 and NaD2 Induce Different Stress Response Pathways in Fungi

    PubMed Central

    Dracatos, Peter M.; Payne, Jennifer; Di Pietro, Antonio; Anderson, Marilyn A.; Plummer, Kim M.

    2016-01-01

    Nicotiana alata defensins 1 and 2 (NaD1 and NaD2) are plant defensins from the ornamental tobacco that have antifungal activity against a variety of fungal pathogens. Some plant defensins interact with fungal cell wall O-glycosylated proteins. Therefore, we investigated if this was the case for NaD1 and NaD2, by assessing the sensitivity of the three Aspergillus nidulans (An) O-mannosyltransferase (pmt) knockout (KO) mutants (An∆pmtA, An∆pmtB, and An∆pmtC). An∆pmtA was resistant to both defensins, while An∆pmtC was resistant to NaD2 only, suggesting NaD1 and NaD2 are unlikely to have a general interaction with O-linked side chains. Further evidence of this difference in the antifungal mechanism was provided by the dissimilarity of the NaD1 and NaD2 sensitivities of the Fusarium oxysporum f. sp. lycopersici (Fol) signalling knockout mutants from the cell wall integrity (CWI) and high osmolarity glycerol (HOG) mitogen-activated protein kinase (MAPK) pathways. HOG pathway mutants were sensitive to both NaD1 and NaD2, while CWI pathway mutants only displayed sensitivity to NaD2. PMID:27598152

  16. Plant Defensins NaD1 and NaD2 Induce Different Stress Response Pathways in Fungi.

    PubMed

    Dracatos, Peter M; Payne, Jennifer; Di Pietro, Antonio; Anderson, Marilyn A; Plummer, Kim M

    2016-01-01

    Nicotiana alata defensins 1 and 2 (NaD1 and NaD2) are plant defensins from the ornamental tobacco that have antifungal activity against a variety of fungal pathogens. Some plant defensins interact with fungal cell wall O-glycosylated proteins. Therefore, we investigated if this was the case for NaD1 and NaD2, by assessing the sensitivity of the three Aspergillus nidulans (An) O-mannosyltransferase (pmt) knockout (KO) mutants (An∆pmtA, An∆pmtB, and An∆pmtC). An∆pmtA was resistant to both defensins, while An∆pmtC was resistant to NaD2 only, suggesting NaD1 and NaD2 are unlikely to have a general interaction with O-linked side chains. Further evidence of this difference in the antifungal mechanism was provided by the dissimilarity of the NaD1 and NaD2 sensitivities of the Fusarium oxysporum f. sp. lycopersici (Fol) signalling knockout mutants from the cell wall integrity (CWI) and high osmolarity glycerol (HOG) mitogen-activated protein kinase (MAPK) pathways. HOG pathway mutants were sensitive to both NaD1 and NaD2, while CWI pathway mutants only displayed sensitivity to NaD2. PMID:27598152

  17. Multi-domain training in healthy old age: Hotel Plastisse as an iPad-based serious game to systematically compare multi-domain and single-domain training

    PubMed Central

    Binder, Julia C.; Zöllig, Jacqueline; Eschen, Anne; Mérillat, Susan; Röcke, Christina; Schoch, Sarah F.; Jäncke, Lutz; Martin, Mike

    2015-01-01

    Finding effective training interventions for declining cognitive abilities in healthy aging is of great relevance, especially in view of the demographic development. Since it is assumed that transfer from the trained to untrained domains is more likely to occur when training conditions and transfer measures share a common underlying process, multi-domain training of several cognitive functions should increase the likelihood of such an overlap. In the first part, we give an overview of the literature showing that cognitive training using complex tasks, such as video games, leisure activities, or practicing a series of cognitive tasks, has shown promising results regarding transfer to a number of cognitive functions. These studies, however, do not allow direct inference about the underlying functions targeted by these training regimes. Custom-designed serious games allow to design training regimes according to specific cognitive functions and a target population's need. In the second part, we introduce the serious game Hotel Plastisse as an iPad-based training tool for older adults that allows the comparison of the simultaneous training of spatial navigation, visuomotor function, and inhibition to the training of each of these functions separately. Hotel Plastisse not only defines the cognitive functions of the multi-domain training clearly, but also implements training in an interesting learning environment including adaptive difficulty and feedback. We propose this novel training tool with the goal of furthering our understanding of how training regimes should be designed in order to affect cognitive functioning of older adults most broadly. PMID:26257643

  18. Multi-domain training in healthy old age: Hotel Plastisse as an iPad-based serious game to systematically compare multi-domain and single-domain training.

    PubMed

    Binder, Julia C; Zöllig, Jacqueline; Eschen, Anne; Mérillat, Susan; Röcke, Christina; Schoch, Sarah F; Jäncke, Lutz; Martin, Mike

    2015-01-01

    Finding effective training interventions for declining cognitive abilities in healthy aging is of great relevance, especially in view of the demographic development. Since it is assumed that transfer from the trained to untrained domains is more likely to occur when training conditions and transfer measures share a common underlying process, multi-domain training of several cognitive functions should increase the likelihood of such an overlap. In the first part, we give an overview of the literature showing that cognitive training using complex tasks, such as video games, leisure activities, or practicing a series of cognitive tasks, has shown promising results regarding transfer to a number of cognitive functions. These studies, however, do not allow direct inference about the underlying functions targeted by these training regimes. Custom-designed serious games allow to design training regimes according to specific cognitive functions and a target population's need. In the second part, we introduce the serious game Hotel Plastisse as an iPad-based training tool for older adults that allows the comparison of the simultaneous training of spatial navigation, visuomotor function, and inhibition to the training of each of these functions separately. Hotel Plastisse not only defines the cognitive functions of the multi-domain training clearly, but also implements training in an interesting learning environment including adaptive difficulty and feedback. We propose this novel training tool with the goal of furthering our understanding of how training regimes should be designed in order to affect cognitive functioning of older adults most broadly.

  19. Na+ channel function, regulation, structure, trafficking and sequestration

    PubMed Central

    Chen-Izu, Ye; Shaw, Robin M; Pitt, Geoffrey S; Yarov-Yarovoy, Vladimir; Sack, Jon T; Abriel, Hugues; Aldrich, Richard W; Belardinelli, Luiz; Cannell, Mark B; Catterall, William A; Chazin, Walter J; Chiamvimonvat, Nipavan; Deschenes, Isabelle; Grandi, Eleonora; Hund, Thomas J; Izu, Leighton T; Maier, Lars S; Maltsev, Victor A; Marionneau, Celine; Mohler, Peter J; Rajamani, Sridharan; Rasmusson, Randall L; Sobie, Eric A; Clancy, Colleen E; Bers, Donald M

    2015-01-01

    This paper is the second of a series of three reviews published in this issue resulting from the University of California Davis Cardiovascular Symposium 2014: Systems approach to understanding cardiac excitation–contraction coupling and arrhythmias: Na+ channel and Na+ transport. The goal of the symposium was to bring together experts in the field to discuss points of consensus and controversy on the topic of sodium in the heart. The present review focuses on Na+ channel function and regulation, Na+ channel structure and function, and Na+ channel trafficking, sequestration and complexing. PMID:25772290

  20. Determination of Na(2)O from sodium aluminate NaAlO(2).

    PubMed

    Näykki, T; Raimo, A; Paavo, P; Antero, K; Päivi, N

    2000-07-31

    The aim of the work was to find a suitable method and conditions for determining Na(2)O wt.% from NaAlO(2). Problems were encountered while titrating NaAlO(2) with hydrochloric acid. The problematic area was the pH range 4-10 where aluminum precipitates as hydroxides. The different species of the aluminate solution were determined using potentiometric and complexometric titrations. The equivalent point of the potentiometric titration was detected using Gran's plotting method. Precipitation of aluminum hydroxides did not interfere with titrations, because in potentiometric titrations the pH value was over 10 and in complexometric titrations the pH was 4. The results were accurate and determinations were easy to carry out. Sodium was also determined by DCP-AES.

  1. Synthesis of Na-A and/or Na-X zeolite/porous carbon composites from carbonized rice husk

    SciTech Connect

    Katsuki, Hiroaki; Komarneni, Sridhar

    2009-07-15

    Na-A and/or Na-X zeolite/porous carbon composites were prepared under hydrothermal conditions by NaOH dissolution of silica first from carbonized rice husk followed by addition of NaAlO{sub 2} and in situ crystallization of zeolites i.e., using a two-step process. When a one-step process was used, both Na-A and Na-X zeolites crystallized on the surface of carbon. Na-A or Na-X zeolite crystals were prepared on the porous carbonized rice husk at 90 deg. C for 2-6 h by changing the SiO{sub 2}/Al{sub 2}O{sub 3}, H{sub 2}O/Na{sub 2}O and Na{sub 2}O/SiO{sub 2} molar ratios of precursors in the two-step process. The surface area and NH{sub 4}{sup +}-cation exchange capacity (CEC) of Na-A zeolite/porous carbon were found to be 171 m{sup 2}/g and 506 meq/100 g, respectively, while those of Na-X zeolite/porous carbon composites were 676 m{sup 2}/g and 317 meq/100 g, respectively. Na-A and Na-X zeolites are well-known microporous and hydrophilic materials while carbonized rice husk was found to be mesoporous (pores of {approx}3.9 nm) and hydrophobic. These hybrid microporous-mesoporous and hydrophilic-hydrophobic composites are expected to be useful for decontamination of metal cations as well as organic contaminants simultaneously. - Graphical Abstract: Novel Na-X zeolite/porous carbon composite.

  2. Specific oxidation pattern of soluble starch with TEMPO-NaBr-NaClO system.

    PubMed

    Hao, Jie; Lu, Jiaojiao; Xu, Naiyu; Linhardt, Robert J; Zhang, Zhenqing

    2016-08-01

    Oxidized starch, one of the most important starch derivatives, has many different properties and applications. Currently, there are two ways to produce oxidized starch, through specific and nonspecific oxidation. Specific oxidation using the stable nitroxyl radical, 2,2,6,6-tetramethyl preparidinloxy (TEMPO), with NaBr and NaClO can produce oxidized starches with different properties under good quality control. In the current study, we examine the products of specifically oxidized starch. As the amount of oxidant and the temperature, two critical factors impacting the oxidation of starch were thoroughly investigated. Analysis of the molecular weight (MW), degree of oxidization (DO) and the detailed structures of corresponding products was accomplished using gel permeation chromatography with multi-angle laser light scattering (GPC-MALLS), infrared (IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, and quadrapole time-of-flight mass spectrometry (Q/TOF-MS). According to the analytical results, the oxidation patterns of starch treated with specific oxidant TEMPO-NaBr-NaClO were established. When high amounts of oxidant was applied, more glucose residues within starch were oxidized to glucuronic acids (higher DO) and substantial degradation to starch oligosaccharides was observed. By selecting a reaction temperature of 25°C a high DO could be obtained for a given amount of oxidant. The reducing end sugar residue within oxidized starch was itself oxidized and ring opened in all TEMPO-NaBr-NaClO reactions. Furthermore, extra oxidant generated additional novel structures in the reducing end residues of some products, particularly in low temperature reactions.

  3. Specific oxidation pattern of soluble starch with TEMPO-NaBr-NaClO system.

    PubMed

    Hao, Jie; Lu, Jiaojiao; Xu, Naiyu; Linhardt, Robert J; Zhang, Zhenqing

    2016-08-01

    Oxidized starch, one of the most important starch derivatives, has many different properties and applications. Currently, there are two ways to produce oxidized starch, through specific and nonspecific oxidation. Specific oxidation using the stable nitroxyl radical, 2,2,6,6-tetramethyl preparidinloxy (TEMPO), with NaBr and NaClO can produce oxidized starches with different properties under good quality control. In the current study, we examine the products of specifically oxidized starch. As the amount of oxidant and the temperature, two critical factors impacting the oxidation of starch were thoroughly investigated. Analysis of the molecular weight (MW), degree of oxidization (DO) and the detailed structures of corresponding products was accomplished using gel permeation chromatography with multi-angle laser light scattering (GPC-MALLS), infrared (IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, and quadrapole time-of-flight mass spectrometry (Q/TOF-MS). According to the analytical results, the oxidation patterns of starch treated with specific oxidant TEMPO-NaBr-NaClO were established. When high amounts of oxidant was applied, more glucose residues within starch were oxidized to glucuronic acids (higher DO) and substantial degradation to starch oligosaccharides was observed. By selecting a reaction temperature of 25°C a high DO could be obtained for a given amount of oxidant. The reducing end sugar residue within oxidized starch was itself oxidized and ring opened in all TEMPO-NaBr-NaClO reactions. Furthermore, extra oxidant generated additional novel structures in the reducing end residues of some products, particularly in low temperature reactions. PMID:27112871

  4. Evaluation of the channelized Hotelling observer with an internal-noise model in a train-test paradigm for cardiac SPECT defect detection

    NASA Astrophysics Data System (ADS)

    Brankov, Jovan G.

    2013-10-01

    The channelized Hotelling observer (CHO) has become a widely used approach for evaluating medical image quality, acting as a surrogate for human observers in early-stage research on assessment and optimization of imaging devices and algorithms. The CHO is typically used to measure lesion detectability. Its popularity stems from experiments showing that the CHO's detection performance can correlate well with that of human observers. In some cases, CHO performance overestimates human performance; to counteract this effect, an internal-noise model is introduced, which allows the CHO to be tuned to match human-observer performance. Typically, this tuning is achieved using example data obtained from human observers. We argue that this internal-noise tuning step is essentially a model training exercise; therefore, just as in supervised learning, it is essential to test the CHO with an internal-noise model on a set of data that is distinct from that used to tune (train) the model. Furthermore, we argue that, if the CHO is to provide useful insights about new imaging algorithms or devices, the test data should reflect such potential differences from the training data; it is not sufficient simply to use new noise realizations of the same imaging method. Motivated by these considerations, the novelty of this paper is the use of new model selection criteria to evaluate ten established internal-noise models, utilizing four different channel models, in a train-test approach. Though not the focus of the paper, a new internal-noise model is also proposed that outperformed the ten established models in the cases tested. The results, using cardiac perfusion SPECT data, show that the proposed train-test approach is necessary, as judged by the newly proposed model selection criteria, to avoid spurious conclusions. The results also demonstrate that, in some models, the optimal internal-noise parameter is very sensitive to the choice of training data; therefore, these models are prone

  5. Prediction of human observer performance in a 2-alternative forced choice low-contrast detection task using channelized Hotelling observer: Impact of radiation dose and reconstruction algorithms

    SciTech Connect

    Yu Lifeng; Leng Shuai; Chen Lingyun; Kofler, James M.; McCollough, Cynthia H.; Carter, Rickey E.

    2013-04-15

    Purpose: Efficient optimization of CT protocols demands a quantitative approach to predicting human observer performance on specific tasks at various scan and reconstruction settings. The goal of this work was to investigate how well a channelized Hotelling observer (CHO) can predict human observer performance on 2-alternative forced choice (2AFC) lesion-detection tasks at various dose levels and two different reconstruction algorithms: a filtered-backprojection (FBP) and an iterative reconstruction (IR) method. Methods: A 35 Multiplication-Sign 26 cm{sup 2} torso-shaped phantom filled with water was used to simulate an average-sized patient. Three rods with different diameters (small: 3 mm; medium: 5 mm; large: 9 mm) were placed in the center region of the phantom to simulate small, medium, and large lesions. The contrast relative to background was -15 HU at 120 kV. The phantom was scanned 100 times using automatic exposure control each at 60, 120, 240, 360, and 480 quality reference mAs on a 128-slice scanner. After removing the three rods, the water phantom was again scanned 100 times to provide signal-absent background images at the exact same locations. By extracting regions of interest around the three rods and on the signal-absent images, the authors generated 21 2AFC studies. Each 2AFC study had 100 trials, with each trial consisting of a signal-present image and a signal-absent image side-by-side in randomized order. In total, 2100 trials were presented to both the model and human observers. Four medical physicists acted as human observers. For the model observer, the authors used a CHO with Gabor channels, which involves six channel passbands, five orientations, and two phases, leading to a total of 60 channels. The performance predicted by the CHO was compared with that obtained by four medical physicists at each 2AFC study. Results: The human and model observers were highly correlated at each dose level for each lesion size for both FBP and IR. The

  6. Single Room Occupancy (SRO) hotels as mental health risk environments among impoverished women: the intersection of policy, drug use, trauma, and urban space

    PubMed Central

    Knight, Knight R.; Lopez, Andrea M.; Comfort, Megan; Shumway, Martha; Cohen, Jennifer; Riley, Elise

    2014-01-01

    Due to the significantly high levels of comorbid substance use and mental health diagnosis among urban poor populations, examining the intersection of drug policy and place requires a consideration of the role of housing in drug user mental health. In San Francisco, geographic boundedness and progressive health and housing polices have coalesced to make single room occupancy hotels (SROs) a key urban built environment used to house poor populations with co-occurring drug use and mental health issues. Unstably housed women who use illicit drugs have high rates of lifetime and current trauma, which manifests in disproportionately high rates of post-traumatic stress disorder (PTSD), anxiety, and depression when compared to stably housed women. We report data from a qualitative interview study (n=30) and four years of ethnography conducted with housing policy makers and unstably housed women who use drugs and live in SROs. Women in the study lived in a range of SRO built environments, from publicly-funded, newly built SROs to privately-owned, dilapidated buildings, which presented a rich opportunity for ethnographic comparison. Applying Rhodes et al.’s framework of socio-structural vulnerability, we explore how SROs can operate as “mental health risk environments” in which macro-structural factors (housing policies shaping the built environment) interact with meso-level factors (social relations within SROs) and micro-level, behavioral coping strategies to impact women’s mental health. The degree to which SRO built environments were “trauma-sensitive” at the macro level significantly influenced women’s mental health at meso- and micro- levels. Women who were living in SROs which exacerbated fear and anxiety attempted, with limited success, to deploy strategies on the meso- and micro- level to manage their mental health symptoms. Study findings underscore the importance of housing polices which consider substance use in the context of current and

  7. Respiratory-driven Na+ electrical potential in the bacterium Vitreoscilla.

    PubMed

    Efiok, B J; Webster, D A

    1990-05-15

    Vitreoscilla is a Gram-negative bacterium with unique respiratory physiology in which Na+ was implicated as a coupling cation for the generation of a transmembrane electrical gradient (delta psi). Thus, cells respiring in the presence of 110 mM Na+ generated a delta psi of -142 mV compared to only -42 and -56 mV for Li+ and choline, respectively, and even the -42 and -56 mV were insensitive to the protonophore 3,5-di-tert-butyl-4-hydroxybenzaldehyde (DTHB). The kinetics of delta psi formation and collapse correlated well with the kinetics of Na+ fluxes but not with those of H+ fluxes. Cyanide inhibited respiration, Na+ extrusion, and delta psi formation 81% or more, indicating that delta psi formation and Na+ extrusion were coupled to respiration. Experiments were performed to distinguish among three possible transport systems for this coupling: (1) a Na(+)-transporting ATPase; (2) an electrogenic Na+/H+ antiport system; (3) a primary Na+ pump directly driven by the free energy of electron transport. DCCD and arsenate decreased cellular ATP up to 86% but had no effect on delta psi, evidence against a Na(+)-transporting ATPase. Low concentrations of DTHB had no effect on delta psi; high concentrations transiently collapsed delta psi, but led to a stimulation of Na+ extrusion, the opposite of that expected for a Na+/H+ antiport system. Potassium ion, which collapses delta psi, also stimulated Na+ extrusion. The experimental evidence is against Na+ extrusion by mechanisms 1 and 2 and supports the existence of a respiratory-driven primary Na+ pump for generating delta psi in Vitreoscilla. PMID:2372555

  8. Design and implementation of the NaI(Tl)/CsI(Na) detectors output signal generator

    NASA Astrophysics Data System (ADS)

    Zhou, Xu; Liu, Cong-Zhan; Zhao, Jian-Ling; Zhang, Fei; Zhang, Yi-Fei; Li, Zheng-Wei; Zhang, Shuo; Li, Xu-Fang; Lu, Xue-Feng; Xu, Zhen-Ling; Lu, Fang-Jun

    2014-02-01

    We designed and implemented a signal generator that can simulate the output of the NaI(Tl)/CsI(Na) detectors' pre-amplifier onboard the Hard X-ray Modulation Telescope (HXMT). Using the development of the FPGA (Field Programmable Gate Array) with VHDL language and adding a random constituent, we have finally produced the double exponential random pulse signal generator. The statistical distribution of the signal amplitude is programmable. The occurrence time intervals of the adjacent signals contain negative exponential distribution statistically.

  9. Direct Reactions with MoNA-LISA

    NASA Astrophysics Data System (ADS)

    Kuchera, Anthony

    2016-03-01

    Nuclear reactions can be used to probe the structure of nuclei. Direct reactions, which take place on short time scales, are well-suited for experiments with beams of short-lived nuclei. One such reaction is nucleon knockout where a proton or neutron is removed from the incoming beam from the interaction with a target. Single nucleon knockout reactions have been used to study the single-particle nature of nuclear wave functions. A recent experiment at the National Superconducting Cyclotron Laboratory was performed to measure cross sections from single nucleon knockout reactions for several p-shell nuclei. Detection of the residual nucleus in coincidence with any gamma rays emitted from the target allowed cross sections to ground and excited states to be measured. Together with input from reaction theory, ab initio structure theories can be tested. Simultaneously the accuracy of knockout reaction models can be validated by detecting the knocked out neutron with the Modular Neutron Array and Large multi-Institutional Scintillator Array (MoNA-LISA). Preliminary results from this experiment will be shown. Knockout reactions can also be used to populate nuclei which are neutron unbound, thus emit neutrons nearly instantaneously. The structure of these nuclei, therefore, cannot be probed with gamma ray spectroscopy. However, with large neutron detectors like MoNA-LISA the properties of these short-lived nuclei are able to be measured. Recent results using MoNA-LISA to study the structure of neutron-rich nuclei will be presented. The author would like to acknowledge support from the NNSA and NSF.

  10. The National Crisis in Education: An Appeal to the People. Report of the Proceedings of the National Citizens Conference on Education Called by the United States Commissioner of Education and Held at the Washington Hotel, Washington, D. C.. May 19, 20, 21, 1920. Bulletin, 1920, No. 29

    ERIC Educational Resources Information Center

    Bawden, William, Ed.

    1920-01-01

    This publication presents the papers presented at the Proceedings of the National Citizens Conference on Education held at the Washington Hotel, Washington last May 19-21, 1920. The purpose of the conference is to capitalize for the new era the interest in education that is springing up in all parts of the country, and to organize it for effective…

  11. The NA62 spectrometer acquisition system

    NASA Astrophysics Data System (ADS)

    Azorskiy, N.; Ceccucci, A.; Bendotti, J.; Danielsson, H.; Degrange, J.; Dixon, N.; Elsha, V.; Enik, T.; Glonti, L.; Gusakov, Y.; Kakurin, S.; Kekelidze, V.; Kislov, E.; Kolesnikov, A.; Koval, M.; Lichard, P.; Madigozhin, D.; Morant, J.; Movchan, S.; Perez Gomez, F.; Palladino, V.; Polenkevich, I.; Potrebenikov, Y.; Ruggiero, G.; Samsonov, V.; Shkarovskiy, S.; Sotnikov, A.

    2016-02-01

    The NA62 low mass spectrometer consists of 7000 straw tubes operating in vacuum. The front-end electronics is directly mounted on the detector and connected by a flexible PCB. The front-end board provides the amplification, shaping, discrimination and time measurements of the analogue signals from 16 channels. After digitisation the data is sent to a VME 9U read-out board. The data, once matched with the trigger, is sent to the next step and used by the trigger level 1 algorithm. The front-end and read-out systems of the detector will be presented along with the first results of the detector performances.

  12. [Effects of NaCl stress on the seedling growth and K(+)- and Na(+) -allocation of four leguminous tree species].

    PubMed

    Mo, Hai-Bo; Yin, Yun-Long; Lu, Zhi-Guo; Wei, Xiu-Jun; Xu, Jian-Hua

    2011-05-01

    Taking the pot-cultured seedlings of four leguminous tree species (Albizia julibrissin, Robinia pseudoacacia, Sophora japonica, and Gleditsia sinensis) as test materials, this paper studied their growth indices, critical salt concentration (C50), and K+ and Na+ allocation under different levels of NaCl stress, aimed to understand the difference of test tree species in salt tolerance. NaCl stress inhibited the seedling growth of the tree species. Under NaCl stress, the dry matter accumulation decreased, while the root/shoot ratio increased, especially for A. julibrissin and G. sinensis. Quadratic regression analysis showed that the C50 of A. julibrissin, R. pseudoacacia, S. japonica, and G. sinensis was 3.0 per thousand, 5.0 per thousand, 4.5 per thousand, and 3.9 per thousand, respectively, i.e., the salt tolerance of the four tree species was in the order of R. pseudoacacia > S. japonica > G. sinensis > A. julibrissin. In the root, stem, and leaf of the four tree species seedlings, the Na+ content increased with the increase of NaCl stress, while the K+ content (except in the root of A. julibrissin) decreased after an initial increase, resulting in a larger difference in the K+/Na+ ratio in the organs. Under the same NaCl stress, the allocation of Na+ in different organs of the four tree species seedlings decreased in the order of root>stem>leaf, while that of K+ differed with tree species and NaCl stress, and leaf was the main storage organ for K+. The K+/Na+ ratio in different organs decreased in the sequence of leaf>stem>root. R. pseudoacacia under NaCl stress accumulated more K+ and less Na+ in stem and leaf, and had higher K+/Na+ ratio in all organs and higher dry mass, being assessed to be more salt-tolerant. In contrast, A. julibrissin under high NaCl stress accumulated more Na+ in stem and leaf, and had a lower K+/Na+ ratio in all organs and lower dry mass, being evaluated to be lesser salt-tolerant. The K+ accumulation in seedling stem and leaf and the Na

  13. Asymmetry of Na-K-Cl cotransport in human erythrocytes.

    PubMed

    Kracke, G R; Anatra, M A; Dunham, P B

    1988-02-01

    The Na-K-Cl cotransport system in human erythrocytes was studied by measuring net influxes and effluxes of Na and K. The influx of K was shown to be stimulated by Na and the influx of Na was stimulated by K, satisfying the fundamental criterion of cotransport. In addition, these mutually stimulating cation influxes had a stoichiometry of 1:1 and were entirely inhibited by furosemide; these results are also consistent with cotransport. Furthermore, the mutually stimulating influxes were entirely dependent on Cl, since they were abolished when nitrate was substituted for Cl. In contrast, cotransport, defined by mutual dependence of fluxes, was not detected in the outward direction over a range of cellular Na and K concentrations from 0 to 50 mmol/l cells. The cotransport pathway did, however, appear to mediate a Na-stimulated K efflux (but no K-stimulated Na efflux), and furosemide-inhibitable effluxes of both Na and K. Nitrate (but not sulfate) appeared to substitute for chloride in promoting Na-stimulated K efflux. Thus the Na-K-Cl cotransport system in human red cells is intrinsically asymmetric, and mediates coupled cation fluxes readily only in the inward direction. PMID:3348364

  14. Hydrogen sulfide induced disruption of Na+ homeostasis in the cortex.

    PubMed

    Chao, Dongman; He, Xiaozhou; Yang, Yilin; Balboni, Gianfranco; Salvadori, Severo; Kim, Dong H; Xia, Ying

    2012-07-01

    Maintenance of ionic balance is essential for neuronal functioning. Hydrogen sulfide (H(2)S), a known toxic environmental gaseous pollutant, has been recently recognized as a gasotransmitter involved in numerous biological processes and is believed to play an important role in the neural activities under both physiological and pathological conditions. However, it is unclear if it plays any role in maintenance of ionic homeostasis in the brain under physiological/pathophysiological conditions. Here, we report by directly measuring Na(+) activity using Na(+) selective electrodes in mouse cortical slices that H(2)S donor sodium hydrosulfide (NaHS) increased Na(+) influx in a concentration-dependent manner. This effect could be partially blocked by either Na(+) channel blocker or N-methyl-D-aspartate receptor (NMDAR) blocker alone or almost completely abolished by coapplication of both blockers but not by non-NMDAR blocker. These data suggest that increased H(2)S in pathophysiological conditions, e.g., hypoxia/ischemia, potentially causes a disruption of ionic homeostasis by massive Na(+) influx through Na(+) channels and NMDARs, thus injuring neural functions. Activation of delta-opioid receptors (DOR), which reduces Na(+) currents/influx in normoxia, had no effect on H(2)S-induced Na(+) influx, suggesting that H(2)S-induced disruption of Na(+) homeostasis is resistant to DOR regulation and may play a major role in neuronal injury in pathophysiological conditions, e.g., hypoxia/ischemia.

  15. Minimizing Load Effects on NA4 Gear Vibration Diagnostic Parameter

    NASA Technical Reports Server (NTRS)

    Dempsey, Paula J.; Zakrajsek, James J.

    2001-01-01

    NA4 is a vibration diagnostic parameter, developed by researchers at NASA Glenn Research Center, for health monitoring of gears in helicopter transmissions. The NA4 reacts to the onset of gear pitting damage and continues to react to the damage as it spreads. This research also indicates NA4 reacts similarly to load variations. The sensitivity of NA4 to load changes will substantially affect its performance on a helicopter gearbox that experiences continuously changing load throughout its flight regimes. The parameter NA4 has been used to monitor gear fatigue tests at constant load. At constant load, NA4 effectively detects the onset of pitting damage and tracks damage severity. Previous research also shows that NA4 reacts to changes in load applied to the gears in the same way it reacts to the onset of pitting damage. The method used to calculate NA4 was modified to minimize these load effects. The modified NA4 parameter was applied to four sets of experimental data. Results indicate the modified NA4 is no longer sensitive to load changes, but remains sensitive to pitting damage.

  16. Naïve point estimation.

    PubMed

    Lindskog, Marcus; Winman, Anders; Juslin, Peter

    2013-05-01

    The capacity of short-term memory is a key constraint when people make online judgments requiring them to rely on samples retrieved from memory (e.g., Dougherty & Hunter, 2003). In this article, the authors compare 2 accounts of how people use knowledge of statistical distributions to make point estimates: either by retrieving precomputed large-sample representations or by retrieving small samples of similar observations post hoc at the time of judgment, as constrained by short-term memory capacity (the naïve sampling model: Juslin, Winman, & Hansson, 2007). Results from four experiments support the predictions by the naïve sampling model, including that participants sometimes guess values that they, when probed, demonstrably know have the lowest probability of occurring. Experiment 1 also demonstrated the operations of an unpredicted recognition-based inference. Computational modeling also incorporating this process demonstrated that the data from all 4 experiments were better predicted by assuming a post hoc sampling process constrained by short-term memory capacity than by assuming abstraction of large-sample representations of the distribution. PMID:22905935

  17. Apical Na+ permeability of frog skin during serosal Cl- replacement.

    PubMed

    Leibowich, S; DeLong, J; Civan, M M

    1988-05-01

    Gluconate substitution for serosal Cl- reduces the transepithelial short-circuit current (Isc) and depolarizes short-circuited frog skins. These effects could result either from inhibition of basolateral K+ conductance, or from two actions to inhibit both apical Na+ permeability (PapNa) and basolateral pump activity. We have addressed this question by studying whole-and split-thickness frog skins. Intracellular Na+ concentration (CcNa) and PapNa have been monitored by measuring the current-voltage relationship for apical Na+ entry. This analysis was conducted by applying trains of voltage pulses, with pulse durations of 16 to 32 msec. Estimates of PapNa and CcNa were not detectably dependent on pulse duration over the range 16 to 80 msec. Serosal Cl- replacement uniformly depolarized short-circuited tissues. The depolarization was associated with inhibition of Isc across each split skin, but only occasionally across the whole-thickness preparations. This difference may reflect the better ionic exchange between the bulk medium and the extracellular fluid in contact with the basolateral membranes, following removal of the underlying dermis in the split-skin preparations. PapNa was either unchanged or increased, and CcNa either unchanged or reduced after the anionic replacement. These data are incompatible with the concept that serosal Cl- replacement inhibits PapNa and Na,K-pump activity. Gluconate substitution likely reduces cell volume, triggering inhibition of the basolateral K+ channels, consistent with the data and conclusions of S.A. Lewis, A.G. Butt, M.J. Bowler, J.P. Leader and A.D.C. Macknight (J. Membrane Biol. 83:119-137, 1985) for toad bladder. The resulting depolarization reduces the electrical force favoring apical Na+ entry. The volume-conductance coupling serves to conserve volume by reducing K+ solute loss. Its molecular basis remains to be identified.

  18. Interaction of the Na+-K+ pump and Na+-Ca2+ exchange via [Na+]i in a restricted space of guinea-pig ventricular cells.

    PubMed

    Fujioka, Y; Matsuoka, S; Ban, T; Noma, A

    1998-06-01

    1. The whole-cell Na+-K+ pump current (INa-K) and Na+-Ca2+ exchange current (INa-Ca) were recorded in guinea-pig ventricular myocytes to study the interaction between the two Na+ transport mechanisms. 2. INa-K was isolated as an external K+-induced current, and INa-Ca as an external Ca2+- induced or Ni2+-sensitive current. The experimental protocol used for one ion carrier did not affect the other. 3. The amplitude of INa-K decreased to 54 +/- 17 % of the initial peak during continuous application of K+ with 20 mM Na+ in the pipette. The outward INa-Ca, which was intermittently activated by brief applications of Ca2+, decreased during activation of INa-K, and recovered after cessation of INa-K activation. These findings revealed a dynamic interaction between INa-K and INa-Ca via a depletion of Na+ under the sarcolemma. 4. To estimate changes in Na+ concentration ([Na+]i) under the sarcolemma, the reversal potential (Vrev) of INa-Ca was measured. Unexpectedly, Vrev hardly changed during activation of INa-K. However, when INa-Ca was blocked by Ni2+ at the same time that INa-K was activated, Vrev changed markedly, maximally by +100 mV, immediately after the removal of Ni2+ and K+. 5. Subsarcolemmal [Na+]i was calculated from the Vrev of INa-Ca on the assumption that the subsarcolemmal Ca2+ concentration ([Ca2+]i) was fixed with EGTA, and mean [Na+]i was calculated from both the time integral of INa-K and the cell volume. The subsarcolemmal [Na+]i was about seven times greater than the mean [Na+]i. 6. The interaction between the Na+-K+ pump and Na+-Ca2+ exchange was well simulated by a diffusion model, in which Na+ diffusion was restricted to one-seventh (14 %) of the total cell volume.

  19. Regulation of persistent Na current by interactions between β subunits of voltage-gated Na channels

    PubMed Central

    Aman, Teresa K.; Grieco-Calub, Tina M.; Chen, Chunling; Rusconi, Raffaella; Slat, Emily A.; Isom, Lori L.; Raman, Indira M.

    2009-01-01

    The β subunits of voltage-gated Na channels (Scnxb) regulate the gating of pore-forming α subunits, as well as their trafficking and localization. In heterologous expression systems, β1, β2, and β3 subunits influence inactivation and persistent current in different ways. To test how the β4 protein regulates Na channel gating, we transfected β4 into HEK cells stably expressing NaV1.1. Unlike a free peptide with a sequence from the β4 cytoplasmic domain, the full-length β4 protein did not block open channels. Instead, β4 expression favored open states by shifting activation curves negative, decreasing the slope of the inactivation curve, and increasing the percentage of non-inactivating current. Consequently, persistent current tripled in amplitude. Expression of β1 or chimeric subunits including the β1 extracellular domain, however, favored inactivation. Co-expressing NaV1.1 and β4 with β1 produced tiny persistent currents, indicating that β1 overcomes the effects of β4 in heterotrimeric channels. In contrast, β1C121W, which contains an extracellular epilepsy-associated mutation, did not counteract the destabilization of inactivation by β4, and also required unusually large depolarizations for channel opening. In cultured hippocampal neurons transfected with β4, persistent current was slightly but significantly increased. Moreover, in β4-expressing neurons from Scn1b and Scn1b/Scn2b null mice, entry into inactivated states was slowed. These data suggest that β1 and β4 have antagonistic roles, the former favoring inactivation and the latter favoring activation. Because increased Na channel availability may facilitate action potential firing, these results suggest a mechanism for seizure susceptibility of both mice and humans with disrupted β1 subunits. PMID:19228957

  20. [Na] and [K] dependence of the Na/K pump current-voltage relationship in guinea pig ventricular myocytes

    PubMed Central

    1989-01-01

    Na/K pump current was determined between -140 and +60 mV as steady- state, strophanthidin-sensitive, whole-cell current in guinea pig ventricular myocytes, voltage-clamped and internally dialyzed via wide- tipped pipettes. Solutions were designed to minimize all other components of membrane current. A device for exchanging the solution inside the pipette permitted investigation of Na/K pump current-voltage (I-V) relationships at several levels of pipette [Na] [( Na]pip) in a single cell; the effects of changes in external [Na] [( Na]o) or external [K] [( K]o) were also studied. At 50 mM [Na]pip, 5.4 mM [K]o, and approximately 150 mM [Na]o, Na/K pump current was steeply voltage dependent at negative potentials but was approximately constant at positive potentials. Under those conditions, reduction of [Na]o enhanced pump current at negative potentials but had little effect at positive potentials: at zero [Na]o, pump current was only weakly voltage dependent. At 5.4 mM [K]o and approximately 150 mM [Na]o, reduction of [Na]pip from 50 mM scaled down the sigmoid pump I-V relationship and shifted it slightly to the right (toward more positive potentials). Pump current at 0 mV was activated by [Na]pip according to the Hill equation with best-fit K0.5 approximately equal to 11 mM and Hill coefficient nH approximately equal to 1.4. At zero [Na]o, reduction of [Na]pip seemed to simply scale down the relatively flat pump I-V relationship: Hill fit parameters for pump activation by [Na]pip at 0 mV were K0.5 approximately equal to 10 mM, nH approximately equal to 1.4. At 50 mM [Na]pip and high [Na]o, reduction of [K]o from 5.4 mM scaled down the sigmoid I-V relationship and shifted it slightly to the right: at 0 mV, K0.5 approximately equal to 1.5 mM and nH approximately equal to 1.0. At zero [Na]o, lowering [K]o simply scaled down the flat pump I-V relationships yielding, at 0 mV, K0.5 approximately equal to 0.2 mM, nH approximately equal to 1.1. The voltage

  1. Coordinated regulation of cardiac Na(+)/Ca (2+) exchanger and Na (+)-K (+)-ATPase by phospholemman (FXYD1).

    PubMed

    Cheung, Joseph Y; Zhang, Xue-Qian; Song, Jianliang; Gao, Erhe; Chan, Tung O; Rabinowitz, Joseph E; Koch, Walter J; Feldman, Arthur M; Wang, JuFang

    2013-01-01

    Phospholemman (PLM) is the founding member of the FXYD family of regulators of ion transport. PLM is a 72-amino acid protein consisting of the signature PFXYD motif in the extracellular N terminus, a single transmembrane (TM) domain, and a C-terminal cytoplasmic tail containing three phosphorylation sites. In the heart, PLM co-localizes and co-immunoprecipitates with Na(+)-K(+)-ATPase, Na(+)/Ca(2+) exchanger, and L-type Ca(2+) channel. The TM domain of PLM interacts with TM9 of the α-subunit of Na(+)-K(+)-ATPase, while its cytoplasmic tail interacts with two small regions (spanning residues 248-252 and 300-304) of the proximal intracellular loop of Na(+)/Ca(2+) exchanger. Under stress, catecholamine stimulation phosphorylates PLM at serine(68), resulting in relief of inhibition of Na(+)-K(+)-ATPase by decreasing K(m) for Na(+) and increasing V(max), and simultaneous inhibition of Na(+)/Ca(2+) exchanger. Enhanced Na(+)-K(+)-ATPase activity lowers intracellular Na(+), thereby minimizing Ca(2+) overload and risks of arrhythmias. Inhibition of Na(+)/Ca(2+) exchanger reduces Ca(2+) efflux, thereby preserving contractility. Thus, the coordinated actions of PLM during stress serve to minimize arrhythmogenesis and maintain inotropy. In acute cardiac ischemia and chronic heart failure, either expression or phosphorylation of PLM or both are altered. PLM regulates important ion transporters in the heart and offers a tempting target for development of drugs to treat heart failure.

  2. Quantitative 23Na magnetic resonance imaging of model foods.

    PubMed

    Veliyulin, Emil; Egelandsdal, Bjørg; Marica, Florin; Balcom, Bruce J

    2009-05-27

    Partial (23)Na MRI invisibility in muscle foods is often referred to as an inherent drawback of the MRI technique, impairing quantitative sodium analysis. Several model samples were designed to simulate muscle foods with a broad variation in protein, fat, moisture, and salt content. (23)Na spin-echo MRI and a recently developed (23)Na SPRITE MRI approach were compared for quantitative sodium imaging, demonstrating the possibility of accurate quantitative (23)Na MRI by the latter method. Good correlations with chemically determined standards were also obtained from bulk (23)Na free induction decay (FID) and CPMG relaxation experiments on the same sample set, indicating their potential use for rapid bulk NaCl measurements. Thus, the sodium MRI invisibility is a methodological problem that can easily be circumvented by using the SPRITE MRI technique. PMID:21314196

  3. Pyrophosphate-fueled Na+ and H+ transport in prokaryotes.

    PubMed

    Baykov, Alexander A; Malinen, Anssi M; Luoto, Heidi H; Lahti, Reijo

    2013-06-01

    In its early history, life appeared to depend on pyrophosphate rather than ATP as the source of energy. Ancient membrane pyrophosphatases that couple pyrophosphate hydrolysis to active H(+) transport across biological membranes (H(+)-pyrophosphatases) have long been known in prokaryotes, plants, and protists. Recent studies have identified two evolutionarily related and widespread prokaryotic relics that can pump Na(+) (Na(+)-pyrophosphatase) or both Na(+) and H(+) (Na(+),H(+)-pyrophosphatase). Both these transporters require Na(+) for pyrophosphate hydrolysis and are further activated by K(+). The determination of the three-dimensional structures of H(+)- and Na(+)-pyrophosphatases has been another recent breakthrough in the studies of these cation pumps. Structural and functional studies have highlighted the major determinants of the cation specificities of membrane pyrophosphatases and their potential use in constructing transgenic stress-resistant organisms.

  4. Simulation of Na D emission near Europa during eclipse

    USGS Publications Warehouse

    Cassidy, T.A.; Johnson, R.E.; Geissler, P.E.; Leblanc, F.

    2008-01-01

    The Cassini imaging science subsystem observed Europa in eclipse during Cassini's Jupiter flyby. The disk-resolved observations revealed a spatially nonuniform emission in the wavelength range of 200-1050 nm (clear filters). By building on observations and simulations of Europa's Na atmosphere and torus we find that electron-excited Na in Europa's tenuous atmosphere can account for the observed emission if the Na is ejected preferentially from Europa's dark terrain. Copyright 2008 by the American Geophysical Union.

  5. Magnesium correction to the NaKCa chemical geothermometer

    USGS Publications Warehouse

    Fournier, R.O.; Potter, R.W., II

    1979-01-01

    Equations and graphs have been devised to correct for the adverse effects of magnesium upon the Na-K-Ca chemical geothermometer. Either the equations or graphs can be used to determine appropriate temperature corrections for given waters with calculated NaKCa temperatures > 70??C and R 50 are probably derived from relatively cool aquifers with temperatures approximately equal to the measured spring temperature, irrespective of much higher calculated Na-K-Ca temperatures. ?? 1979.

  6. Neutron diffraction studies of the Na-ion battery electrode materials NaCoCr2(PO4)3, NaNiCr2(PO4)3, and Na2Ni2Cr(PO4)3

    NASA Astrophysics Data System (ADS)

    Yahia, H. Ben; Essehli, R.; Avdeev, M.; Park, J.-B.; Sun, Y.-K.; Al-Maadeed, M. A.; Belharouak, I.

    2016-06-01

    The new compounds NaCoCr2(PO4)3, NaNiCr2(PO4)3, and Na2Ni2Cr(PO4)3 were synthesized by sol-gel method and their crystal structures were determined by using neutron powder diffraction data. These compounds were characterized by galvanometric cycling and cyclic voltammetry. NaCoCr2(PO4)3, NaNiCr2(PO4)3, and Na2Ni2Cr(PO4)3 crystallize with a stuffed α-CrPO4-type structure. The structure consists of a 3D-framework made of octahedra and tetrahedra that are sharing corners and/or edges generating channels along [100] and [010], in which the sodium atoms are located. Of significance, in the structures of NaNiCr2(PO4)3, and Na2Ni2Cr(PO4)3 a statistical disorder Ni2+/Cr3+ was observed on both the 8g and 4a atomic positions, whereas in NaCoCr2(PO4)3 the statistical disorder Co2+/Cr3+ was only observed on the 8g atomic position. When tested as negative electrode materials, NaCoCr2(PO4)3, NaNiCr2(PO4)3, and Na2Ni2Cr(PO4)3 delivered specific capacities of 352, 385, and 368 mA h g-1, respectively, which attests to the electrochemical activity of sodium in these compounds.

  7. Advanced Intermediate-Temperature Na-S Battery

    SciTech Connect

    Lu, Xiaochuan; Kirby, Brent W.; Xu, Wu; Li, Guosheng; Kim, Jin Yong; Lemmon, John P.; Sprenkle, Vincent L.; Yang, Zhenguo

    2012-11-12

    In this study, we reported an intermediate-temperature (~150°C) sodium-sulfur (Na-S) battery. With a reduced operating temperature, this novel battery can potentially reduce the cost and safety issues associated with the conventional high-temperature (300~350°C) Na-S battery. A dense β"-Al2O3 solid membrane and tetraglyme were utilized as the electrolyte separator and catholyte solvent in this battery. Solubility tests indicated that cathode mixture of Na2S4 and S exhibited extremely high solubility in tetraglyme (e.g., > 4.1 M for Na2S4 + 4 S). CV scans of Na2S4 in tetraglyme revealed two pairs of redox couples with peaks at around 2.22 and 1.75 V, corresponding to the redox reactions of polysulfide species. The discharge/charge profiles of the Na-S battery showed a slope region and a plateau, indicating multiple steps and cell reactions. In-situ Raman measurements during battery operation suggested that polysulfide species were formed in the sequence of Na2S5 + S → Na2S5 + Na2S4Na2S4 + Na2S2 during discharge and in a reverse order during charge. This battery showed dramatic improvement in rate capacity and cycling stability over room-temperature Na-S batteries, which makes it attractive for renewable energy integration and other grid related applications.

  8. Effects of Cl adatom on Na-Decorated graphene

    NASA Astrophysics Data System (ADS)

    Song, Xinxiang; Sun, Yu; Dong, Meifeng; Li, Chun; Wang, Jiesheng; Mimura, Hidenori; Yuan, Guang

    2015-06-01

    The effects of the Cl adatom on Na-decorated graphene are studied using first principles density functional theory under the generalized gradient approximation to calculate the adsorption energy, geometric structure, charge density difference, and density of states. When Na and Cl adatoms are simultaneously absorbed on opposite sides of graphene, the adsorption energy of Na increases by about 1 eV and the adsorption system becomes more stable because graphene can effectively transfer the 3s valence of the Na adatom to the Cl adatom.

  9. Transcriptional regulators of Na,K-ATPase subunits

    PubMed Central

    Li, Zhiqin; Langhans, Sigrid A.

    2015-01-01

    The Na,K-ATPase classically serves as an ion pump creating an electrochemical gradient across the plasma membrane that is essential for transepithelial transport, nutrient uptake and membrane potential. In addition, Na,K-ATPase also functions as a receptor, a signal transducer and a cell adhesion molecule. With such diverse roles, it is understandable that the Na,K-ATPase subunits, the catalytic α-subunit, the β-subunit and the FXYD proteins, are controlled extensively during development and to accommodate physiological needs. The spatial and temporal expression of Na,K-ATPase is partially regulated at the transcriptional level. Numerous transcription factors, hormones, growth factors, lipids, and extracellular stimuli modulate the transcription of the Na,K-ATPase subunits. Moreover, epigenetic mechanisms also contribute to the regulation of Na,K-ATPase expression. With the ever growing knowledge about diseases associated with the malfunction of Na,K-ATPase, this review aims at summarizing the best-characterized transcription regulators that modulate Na,K-ATPase subunit levels. As abnormal expression of Na,K-ATPase subunits has been observed in many carcinoma, we will also discuss transcription factors that are associated with epithelial-mesenchymal transition, a crucial step in the progression of many tumors to malignant disease. PMID:26579519

  10. Kaolin-based geopolymers with various NaOH concentrations

    NASA Astrophysics Data System (ADS)

    Heah, C. Y.; Kamarudin, H.; Mustafa Al Bakri, A. M.; Bnhussain, M.; Luqman, M.; Khairul Nizar, I.; Ruzaidi, C. M.; Liew, Y. M.

    2013-03-01

    Kaolin geopolymers were produced by the alkali-activation of kaolin with an activator solution (a mixture of NaOH and sodium silicate solutions). The NaOH solution was prepared at a concentration of 6-14 mol/L and was mixed with the sodium silicate solution at a Na2SiO3/NaOH mass ratio of 0.24 to prepare an activator solution. The kaolin-to-activator solution mass ratio used was 0.80. This paper aimed to analyze the effect of NaOH concentration on the compressive strength of kaolin geopolymers at 80°C for 1, 2, and 3 d. Kaolin geopolymers were stable in water, and strength results showed that the kaolin binder had adequate compressive strength with 12 mol/L of NaOH concentration. When the NaOH concentration increased, the SiO2/Na2O decreased. The increased Na2O content enhanced the dissolution of kaolin as shown in X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) analyses. However, excess in this content was not beneficial for the strength development of kaolin geopolymers. In addition, there was the formation of more geopolymeric gel in 12 mol/L samples. The XRD pattern of the samples showed a higher amorphous content and a more geopolymer bonding existed as proved by FTIR analysis.

  11. Influenza virus neuraminidase (NA): a target for antivirals and vaccines.

    PubMed

    Jagadesh, Anitha; Salam, Abdul Ajees Abdul; Mudgal, Piya Paul; Arunkumar, Govindakarnavar

    2016-08-01

    Influenza, the most common infectious disease, poses a great threat to human health because of its highly contagious nature and fast transmissibility, often leading to high morbidity and mortality. Effective vaccination strategies may aid in the prevention and control of recurring epidemics and pandemics associated with this infectious disease. However, antigenic shifts and drifts are major concerns with influenza virus, requiring effective global monitoring and updating of vaccines. Current vaccines are standardized primarily based on the amount of hemagglutinin, a major surface antigen, which chiefly constitutes these preparations along with the varying amounts of neuraminidase (NA). Anti-influenza drugs targeting the active site of NA have been in use for more than a decade now. However, NA has not been approved as an effective antigenic component of the influenza vaccine because of standardization issues. Although some studies have suggested that NA antibodies are able to reduce the severity of the disease and induce a long-term and cross-protective immunity, a few major scientific issues need to be addressed prior to launching NA-based vaccines. Interestingly, an increasing number of studies have shown NA to be a promising target for future influenza vaccines. This review is an attempt to consolidate studies that reflect the strength of NA as a suitable vaccine target. The studies discussed in this article highlight NA as a potential influenza vaccine candidate and support taking the process of developing NA vaccines to the next stage. PMID:27255748

  12. Study of OSL in NaF: Ca,Cu

    NASA Astrophysics Data System (ADS)

    More, Y. K.; Wankhede, S. P.; Moharil, S. V.

    2013-06-01

    Sodium Fluoride containing Cu+ ions was prepared by R.A.P. followed by melt-quenching technique. Results on photo, thermo and optically stimulated luminescence in NaF:Ca,Cu are reported. OSL sensitivity of NaF:Ca,Cu is approximately 2 times than that of standard phosphor LMP. The rate of OSL depletion for 90% decay for NaF:Ca,Cu is 0.3 times as that of OSL phosphor LMP. NaF:Ca,Cu thus deserves much more attention than it has received up till now.

  13. Pion and kaon freezeout in NA44

    SciTech Connect

    NA44 Collaboration

    1994-12-01

    The NA44 spectrometer is optimized for the study of single and two-particle particle spectra near mid-rapidity for transverse momenta below {approx} 1 GeV/c. A large fraction of all pairs in the spectrometer`s acceptance are at low relative momenta, resulting in small statistical uncertainties on the extracted size parameters. In addition, the spectrometer`s clean particle identification allows the authors to measure correlation functions for pions, kaons, and protons. This contribution will concentrate on the source size parameters determined from pion and kaon correlation functions. These size parameters will be compared to calculations from the RQMD event generator and also interpreted in the context of a hydrodynamic model. Finally, the measured single particle spectra will be examined from the viewpoint of hydrodynamics.

  14. Mercury's Na Exosphere from MESSENGER Data

    NASA Technical Reports Server (NTRS)

    Killen, Rosemary M.; Burger, M. H.; Cassidy, T. A.; Sarantos, M.; Vervack, R. J.; McClintock, W. El; Merkel, A. W.; Sprague, A. L.; Solomon, S. C.

    2012-01-01

    MESSENGER entered orbit about Mercury on March 18, 2011. Since then, the Ultraviolet and Visible Spectrometer (UWS) channel of MESSENGER's Mercury Atmospheric and Surface Composition Spectrometer (MASCS) has been observing Mercury's exosphere nearly continuously. Daily measurements of Na brightness were fitted with non-uniform exospheric models. With Monte Carlo sampling we traced the trajectories of a representative number of test particles, generally one million per run per source process, until photoionization, escape from the gravitational well, or permanent sticking at the surface removed the atom from the simulation. Atoms were assumed to partially thermally accommodate on each encounter with the surface with accommodation coefficient 0.25. Runs for different assumed source processes are run separately, scaled and co-added. Once these model results were saved onto a 3D grid, we ran lines of sight from the MESSENGER spacecraft :0 infinity using the SPICE kernels and we computed brightness integrals. Note that only particles that contribute to the measurement can be constrained with our method. Atoms and molecules produced on the nightside must escape the shadow in order to scatter light if the excitation process is resonant-light scattering, as assumed here. The aggregate distribution of Na atoms fits a 1200 K gas, with a PSD distribution, along with a hotter component. Our models constrain the hot component, assumed to be impact vaporization, to be emitted with a 2500 K Maxwellian. Most orbits show a dawnside enhancement in the hot component broadly spread over the leading hemisphere. However, on some dates there is no dawn/dusk asymmetry. The portion of the hot/cold source appears to be highly variable.

  15. The naïve intuitive statistician: a naïve sampling model of intuitive confidence intervals.

    PubMed

    Juslin, Peter; Winman, Anders; Hansson, Patrik

    2007-07-01

    The perspective of the naïve intuitive statistician is outlined and applied to explain overconfidence when people produce intuitive confidence intervals and why this format leads to more overconfidence than other formally equivalent formats. The naïve sampling model implies that people accurately describe the sample information they have but are naïve in the sense that they uncritically take sample properties as estimates of population properties. A review demonstrates that the naïve sampling model accounts for the robust and important findings in previous research as well as provides novel predictions that are confirmed, including a way to minimize the overconfidence with interval production. The authors discuss the naïve sampling model as a representative of models inspired by the naïve intuitive statistician. PMID:17638502

  16. Melting properties of radiation-induced Na and Cl2 precipitates in ultra-heavily irradiated NaCl

    NASA Astrophysics Data System (ADS)

    Sugonyako, A. V.; Vainshtein, D. I.; den Hartog, H. P.; Turkin, A. A.; den Hartog, H. W.

    2005-01-01

    Exposure of NaCl to high doses of ionizing radiation leads to the formation of nano-particles of metallic Na, very small chlorine precipitates, vacancy voids, and dislocations. A useful way to monitor the stage of the damage formation process is measuring the latent heat of melting of the Na-particles (100 °C) and chlorine precipitates (-101 °C). In this paper we will present data, showing that for doses in the range of TRad (1010 Gy) the concentration of radiolytic Na may become very large. Even in pure samples, we have converted more than 20% of all NaCl molecules into metallic Na and chlorine, but often higher percentages can be achieved. In this paper we will present new data obtained for ultra-high irradiation doses and a first attempt will be made to understand the results.

  17. Attenuation of Na/K-ATPase Mediated Oxidant Amplification with pNaKtide Ameliorates Experimental Uremic Cardiomyopathy

    PubMed Central

    Liu, Jiang; Tian, Jiang; Chaudhry, Muhammad; Maxwell, Kyle; Yan, Yanling; Wang, Xiaoliang; Shah, Preeya T.; Khawaja, Asad A.; Martin, Rebecca; Robinette, Tylor J.; El-Hamdani, Adee; Dodrill, Michael W.; Sodhi, Komal; Drummond, Christopher A.; Haller, Steven T.; Kennedy, David J.; Abraham, Nader G.; Xie, Zijian; Shapiro, Joseph I.

    2016-01-01

    We have previously reported that the sodium potassium adenosine triphosphatase (Na/K-ATPase) can effect the amplification of reactive oxygen species. In this study, we examined whether attenuation of oxidant stress by antagonism of Na/K-ATPase oxidant amplification might ameliorate experimental uremic cardiomyopathy induced by partial nephrectomy (PNx). PNx induced the development of cardiac morphological and biochemical changes consistent with human uremic cardiomyopathy. Both inhibition of Na/K-ATPase oxidant amplification with pNaKtide and induction of heme oxygenase-1 (HO-1) with cobalt protoporphyrin (CoPP) markedly attenuated the development of phenotypical features of uremic cardiomyopathy. In a reversal study, administration of pNaKtide after the induction of uremic cardiomyopathy reversed many of the phenotypical features. Attenuation of Na/K-ATPase oxidant amplification may be a potential strategy for clinical therapy of this disorder. PMID:27698370

  18. The Hospital as a Hotel

    ERIC Educational Resources Information Center

    Goldstein, Mark Kane; And Others

    1976-01-01

    A rehabilitation unit was established in which patients could develop work skills by day and return to the hospital for recreation, reinforcement, and rest at night. In a three-month follow-up about 50 percent of the discharged patients were working at paid jobs. (Author)

  19. Head nurse or hotel manager?

    PubMed

    McAlvanah, M

    1989-01-01

    The responsibility of making room assignments for patients can be both a challenging and frustrating experience for a head nurse. Many factors must be considered when making room assignments while consumer dissatisfaction with the process must be handled creatively and with understanding. PMID:2734042

  20. RNA adducts with Na 2SeO 4 and Na 2SeO 3 - Stability and structural features

    NASA Astrophysics Data System (ADS)

    Nafisi, Shohreh; Manouchehri, Firouzeh; Montazeri, Maryam

    2011-12-01

    Selenium compounds are widely available in dietary supplements and have been extensively studied for their antioxidant and anticancer properties. Low blood Se levels were found to be associated with an increased incidence and mortality from various types of cancers. Although many in vivo and clinical trials have been conducted using these compounds, their biochemical and chemical mechanisms of efficacy are the focus of much current research. This study was designed to examine the interaction of Na 2SeO 4 and Na 2SeO 3 with RNA in aqueous solution at physiological conditions, using a constant RNA concentration (6.25 mM) and various sodium selenate and sodium selenite/polynucleotide (phosphate) ratios of 1/80, 1/40, 1/20, 1/10, 1/5, 1/2 and 1/1. Fourier transform infrared, UV-Visible spectroscopic methods were used to determine the drug binding modes, the binding constants, and the stability of Na 2SeO 4 and Na 2SeO 3-RNA complexes in aqueous solution. Spectroscopic evidence showed that Na 2SeO 4 and Na 2SeO 3 bind to the major and minor grooves of RNA ( via G, A and U bases) with some degree of the Se-phosphate (PO 2) interaction for both compounds with overall binding constants of K(Na 2SeO 4-RNA) = 8.34 × 10 3 and K(Na 2SeO 3-RNA) = 4.57 × 10 3 M -1. The order of selenium salts-biopolymer stability was Na 2SeO 4-RNA > Na 2SeO 3-RNA. RNA aggregations occurred at higher selenium concentrations. No biopolymer conformational changes were observed upon Na 2SeO 4 and Na 2SeO 3 interactions, while RNA remains in the A-family structure.

  1. Solubility of MgO in MgCl{sub 2}-NaCl-NaF melts

    SciTech Connect

    Mediaas, H.; Vinstad, J.E.; Oestvold, T.

    1996-10-01

    The solubility of MgO in MgCl{sub 2}-NaCl-NaF melts has been measured for melts with varying NaF concentration for x{sub MgCl{sub 2}} = 0.10 and 0.63 and for x{sub MgCl{sub 2}}/x{sub NaCl} = 1.70. Melt samples have been analyzed by carbothermal reduction (Leco TC-436) for total oxide content. The oxide content in the binary melt MgCl{sub 2}-NaCl was also analyzed by Iodometric titration. The results indicate two different oxide-containing species, denoted MgOCl and MgOF, in the solidified samples withdrawn from the melt. The latter appears only in fluoride-containing melts, but may, however, also contain chloride ions. The oxide solubility is increasing with increasing concentration of Mg{sup 2+} in both MgCl{sub 2}-NaCl and MgCl{sub 2}-NaCl-NaF melts. The solubility of MgO is always higher in fluoride containing melts at the same Mg{sup 2+} concentration. In the systems concentrated in MgCl{sub 2}, the increase in oxide solubility as function of x{sub NaF} is more pronounced than what is predicted from a simple model calculation. The increase is much smaller in the x{sub NaF} < 0.2 range for small MgCl{sub 2} contents than predicted from the same model calculation. The introduction of 1.7 mol% NaF to an industrial electrolyte does not seem to change the oxide solubility significantly. In such an electrolyte, where x{sub MgCl{sub 2}} {approx_equal} 0.1, the data gives a constant oxide solubility around 10 ppm O up to 5 mol% NaF.

  2. Elevated [Cl-]i, and [Na+]i inhibit Na+, K+, Cl- cotransport by different mechanisms in squid giant axons

    PubMed Central

    1996-01-01

    Bumetanide-sensitive (BS) unidirectional fluxes of (36)Cl- or (22)Na+ were measured in internally dialyzed squid giant axons while varying the intra- or extracellular concentrations of Na+ and/or Cl-. Raising either [Cl-]i or [Na+]i resulted in a concentration-dependent reduction of the BS influx of both (36)Cl- and (22)Na+. Raising [Cl-]i above 200 mM completely blocked BS influxes. However, raising [Na+]i to 290 mM resulted in saturable but incomplete inhibition of both BS Na+ influx and BS Cl- influx. The consequences of varying intracellular Cl- on cotransporter effluxes were complex. At lower [Cl-]i values (below 100 mM) intracellular Cl- activated cotransporter effluxes. Surprisingly, however, raising [Cl-]i levels > 125 mM resulted in a [Cl-]i-dependent inhibition of BS effluxes of both Na+ and Cl-. On the other hand, raising [Na+]i resulted only in the activation of the BS Na+ efflux; intracellular Na+ did not inhibit BS efflux even at 290 mM. The inhibitory effects of intracellular Na+ on cotransporter-mediated influxes, and lack of inhibitory effects on BS effluxes, are consistent with the trans-side inhibition expected for an ordered binding/release model of cotransporter operation. However, the inhibitory effects of intracellular Cl- on both influxes and effluxes are not explained by such a model. These data suggest that Cl may interact with an intracellular site (or sites), which does not mediate Cl transport, but does modulate the transport activity of the Na+, K+, Cl- cotransporter. PMID:8833345

  3. Elevated [Cl-]i, and [Na+]i inhibit Na+, K+, Cl- cotransport by different mechanisms in squid giant axons.

    PubMed

    Breitwieser, G E; Altamirano, A A; Russell, J M

    1996-02-01

    Bumetanide-sensitive (BS) unidirectional fluxes of (36)Cl- or (22)Na+ were measured in internally dialyzed squid giant axons while varying the intra- or extracellular concentrations of Na+ and/or Cl-. Raising either [Cl-]i or [Na+]i resulted in a concentration-dependent reduction of the BS influx of both (36)Cl- and (22)Na+. Raising [Cl-]i above 200 mM completely blocked BS influxes. However, raising [Na+]i to 290 mM resulted in saturable but incomplete inhibition of both BS Na+ influx and BS Cl- influx. The consequences of varying intracellular Cl- on cotransporter effluxes were complex. At lower [Cl-]i values (below 100 mM) intracellular Cl- activated cotransporter effluxes. Surprisingly, however, raising [Cl-]i levels > 125 mM resulted in a [Cl-]i-dependent inhibition of BS effluxes of both Na+ and Cl-. On the other hand, raising [Na+]i resulted only in the activation of the BS Na+ efflux; intracellular Na+ did not inhibit BS efflux even at 290 mM. The inhibitory effects of intracellular Na+ on cotransporter-mediated influxes, and lack of inhibitory effects on BS effluxes, are consistent with the trans-side inhibition expected for an ordered binding/release model of cotransporter operation. However, the inhibitory effects of intracellular Cl- on both influxes and effluxes are not explained by such a model. These data suggest that Cl may interact with an intracellular site (or sites), which does not mediate Cl transport, but does modulate the transport activity of the Na+, K+, Cl- cotransporter.

  4. A 23Na magic angle spinning nuclear magnetic resonance, XANES, and high-temperature X-ray diffraction study of NaUO3, Na4UO5, and Na2U2O7.

    PubMed

    Smith, A L; Raison, P E; Martel, L; Charpentier, T; Farnan, I; Prieur, D; Hennig, C; Scheinost, A C; Konings, R J M; Cheetham, A K

    2014-01-01

    The valence state of uranium has been confirmed for the three sodium uranates NaU(V)O3/[Rn](5f(1)), Na4U(VI)O5/[Rn](5f(0)), and Na2U(VI)2O7/[Rn](5f(0)), using X-ray absorption near-edge structure (XANES) spectroscopy. Solid-state (23)Na magic angle spinning nuclear magnetic resonance (MAS NMR) measurements have been performed for the first time, yielding chemical shifts at -29.1 (NaUO3), 15.1 (Na4UO5), and -14.1 and -19 ppm (Na1 8-fold coordinated and Na2 7-fold coordinated in Na2U2O7), respectively. The [Rn]5f(1) electronic structure of uranium in NaUO3 causes a paramagnetic shift in comparison to Na4UO5 and Na2U2O7, where the electronic structure is [Rn]5f(0). A (23)Na multi quantum magic angle spinning (MQMAS) study on Na2U2O7 has confirmed a monoclinic rather than rhombohedral structure with evidence for two distinct Na sites. DFT calculations of the NMR parameters on the nonmagnetic compounds Na4UO5 and Na2U2O7 have permitted the differentiation between the two Na sites of the Na2U2O7 structure. The linear thermal expansion coefficients of all three compounds have been determined using high-temperature X-ray diffraction: αa = 22.7 × 10(-6) K(-1), αb = 12.9 × 10(-6) K(-1), αc = 16.2 × 10(-6) K(-1), and αvol = 52.8 × 10(-6) K(-1) for NaUO3 in the range 298-1273 K; αa = 37.1 × 10(-6) K(-1), αc = 6.2 × 10(-6) K(-1), and αvol = 81.8 × 10(-6) K(-1) for Na4UO5 in the range 298-1073 K; αa = 6.7 × 10(-6) K(-1), αb = 14.4 × 10(-6) K(-1), αc = 26.8 × 10(-6) K(-1), αβ = -7.8 × 10(-6) K(-1), and αvol = -217.6 × 10(-6) K(-1) for Na2U2O7 in the range 298-573 K. The α to β phase transition reported for the last compound above about 600 K was not observed in the present studies, either by high-temperature X-ray diffraction or by differential scanning calorimetry. PMID:24350659

  5. Towards environmentally friendly Na-ion batteries: Moisture and water stability of Na2Ti3O7

    NASA Astrophysics Data System (ADS)

    Zarrabeitia, M.; Castillo-Martínez, E.; López Del Amo, J. M.; Eguía-Barrio, A.; Muñoz-Márquez, M. A.; Rojo, T.; Casas-Cabanas, M.

    2016-08-01

    We report here on the moisture and water stability of the promising Na-ion anode material Na2Ti3O7. Spontaneous Na+/H+ exchange is detected by PXRD after air exposure, forming solid solution compounds of the form Na2-xHxTi3O7 (0 < x < 2). By controlled ion exchange in aqueous solution two mixed compositions are prepared and their composition and structure are characterized with a panel of techniques. Both mixed compositions crystallize in C2/m space group like H2Ti3O7, and therefore Na+/H+ exchange is found to involve a structural transition from AA stacking of [TiO6] layers to AB stacking sequence. The electrochemical behaviour of the mixed compositions vs. Na+/Na is studied as well as that of an electrode of pure Na2Ti3O7 prepared in water media. The water-processed electrode is shown to exhibit a superior cycling stability and therefore the results obtained highlight the potential of Na2Ti3O7 as a green, low cost anode material for NIBs.

  6. Estimating the hydrogen ion concentration in concentrated NaCl and Na{sub 2}SO{sub 4} electrolytes

    SciTech Connect

    Rai, D.; Felmy, A.R.; Juracich, S.P.; Rao, F.

    1995-06-01

    Combination glass electrodes were tested for determining H{sup +} concentrations in concentrated pure and mixed NaCl and Na{sub 2}SO{sub 4} solutions, as well as natural brine systems. NaCl, Na{sub 2}SO{sub 4}, and mixtures of NaCl and Na{sub 2}SO{sub 4} solutions were analyzed. Correction factors for estimating pC{sub H}{sup +} (negative logarithm of H{sup +} concentration) were determined from measured/observed pH values. Required Gran-type titrations were done with HCl and/or NaOH. The titration method is described and a step-by-step procedure provided; it has been used previously for determining pC{sub H}{sup +} values of synthetic chloride-dominated brines. Precautions are required to determine correction factors for electrolytes that react with H{sup +} or OH{sup {minus}} [sulfate brines for titration with acid; magnesium brines for titration with base because of precipitation of Mg(OH)2]. Correction factors A (pC{sub H}{sup +} = pH{sub ob} + A) from HCl titrations were similar to those from NaOH titrations where the concentration of free H{sup +} was calculated using a thermodynamic model. These values should be applicable to solns with a very large range in measured pH values (2 to 12). Because a large number of solns were titrated with HCl and the A values are similar for HCl and NaOH titrations, the A values for NaCl and Na2SO4 solns were fit as a function of molality to allow extrapolation. For NaCl solns 0 to 6.0 M, A can be obtained by multiplying the molality by 0.159. For Na2SO4 solns 0 to 2.0 M, the values of A can be obtained from (0.221 {minus} 0.549X + 0.201X{sup 2}), where X is the molality of Na{sub 2}SO{sub 4}. Orion-Ross electrode evaluations indicated that the A values did not differ significantly for different electrodes. Results suggest that the data in this report can be used to estimate A values for different NaCl and Na{sub 2}SO{sub 4} solns even for noncalibrated electrodes.

  7. Towards environmentally friendly Na-ion batteries: Moisture and water stability of Na2Ti3O7

    NASA Astrophysics Data System (ADS)

    Zarrabeitia, M.; Castillo-Martínez, E.; López Del Amo, J. M.; Eguía-Barrio, A.; Muñoz-Márquez, M. A.; Rojo, T.; Casas-Cabanas, M.

    2016-08-01

    We report here on the moisture and water stability of the promising Na-ion anode material Na2Ti3O7. Spontaneous Na+/H+ exchange is detected by PXRD after air exposure, forming solid solution compounds of the form Na2-xHxTi3O7 (0 < x < 2). By controlled ion exchange in aqueous solution two mixed compositions are prepared and their composition and structure are characterized with a panel of techniques. Both mixed compositions crystallize in C2/m space group like H2Ti3O7, and therefore Na+/H+ exchange is found to involve a structural transition from AA stacking of [TiO6] layers to AB stacking sequence. The electrochemical behaviour of the mixed compositions vs. Na+/Na is studied as well as that of an electrode of pure Na2Ti3O7 prepared in water media. The water-processed electrode is shown to exhibit a superior cycling stability and therefore the results obtained highlight the potential of Na2Ti3O7 as a green, low cost anode material for NIBs.

  8. Central role of the Na(+)-translocating NADH:quinone oxidoreductase (Na(+)-NQR) in sodium bioenergetics of Vibrio cholerae.

    PubMed

    Steuber, Julia; Halang, Petra; Vorburger, Thomas; Steffen, Wojtek; Vohl, Georg; Fritz, Günter

    2014-12-01

    Vibrio cholerae is a Gram-negative bacterium that lives in brackish or sea water environments. Strains of V. cholerae carrying the pathogenicity islands infect the human gut and cause the fatal disease cholera. Vibrio cholerae maintains a Na(+) gradient at its cytoplasmic membrane that drives substrate uptake, motility, and efflux of antibiotics. Here, we summarize the major Na(+)-dependent transport processes and describe the central role of the Na(+)-translocating NADH:quinone oxidoreductase (Na(+)-NQR), a primary Na(+) pump, in maintaining a Na(+)-motive force. The Na(+)-NQR is a membrane protein complex with a mass of about 220 kDa that couples the exergonic oxidation of NADH to the transport of Na(+) across the cytoplasmic membrane. We describe the molecular architecture of this respiratory complex and summarize the findings how electron transport might be coupled to Na(+)-translocation. Moreover, recent advances in the determination of the three-dimensional structure of this complex are reported.

  9. Synthesis of NaYF4 and NaLuF4 Based Upconversion Nanocrystals and Comparison of Their Properties.

    PubMed

    Ouyang, Juan; Yin, Dongguang; Song, Kailin; Wang, Chengcheng; Liu, Bing; Wu, Minghong

    2015-04-01

    In this study, four kinds of upconversion nanocrystals (UCNs) have been successfully synthesized by a facile solvothermal method. The morphology, crystalline phase, composition, grain size, upconversion luminescence and cell image of the UCNs were investigated. The properties of the NaLuF4-based UCNs were compared with the counterparts of NaYF4-based UCNs. It is found that the NaLuF4-based UCNs are apt to form hexagonal phase structures, while NaYF4-based UCNs of NaYF4:Yb, Er and NaYF4:Gd, Yb, Er are cubic and hexagonal phases respectively. The upconversion emission intensities of the NaLuF4-based UCNs are higher than that of NaYF4-based UCNs, and Gd3+ presented UCNs are higher than that of Gd3+ absented UCNs. The bioimaging application of NaLuF4:Gd, Yb, Er shows that bright upconversion luminescence can be observed when UCNs-labeled HeLa cells are excited with 980 nm light. PMID:26353495

  10. Synthesis of NaYF4 and NaLuF4 Based Upconversion Nanocrystals and Comparison of Their Properties.

    PubMed

    Ouyang, Juan; Yin, Dongguang; Song, Kailin; Wang, Chengcheng; Liu, Bing; Wu, Minghong

    2015-04-01

    In this study, four kinds of upconversion nanocrystals (UCNs) have been successfully synthesized by a facile solvothermal method. The morphology, crystalline phase, composition, grain size, upconversion luminescence and cell image of the UCNs were investigated. The properties of the NaLuF4-based UCNs were compared with the counterparts of NaYF4-based UCNs. It is found that the NaLuF4-based UCNs are apt to form hexagonal phase structures, while NaYF4-based UCNs of NaYF4:Yb, Er and NaYF4:Gd, Yb, Er are cubic and hexagonal phases respectively. The upconversion emission intensities of the NaLuF4-based UCNs are higher than that of NaYF4-based UCNs, and Gd3+ presented UCNs are higher than that of Gd3+ absented UCNs. The bioimaging application of NaLuF4:Gd, Yb, Er shows that bright upconversion luminescence can be observed when UCNs-labeled HeLa cells are excited with 980 nm light.

  11. Background study of NaI(Tl) crystals for the KIMS-NaI experiment

    NASA Astrophysics Data System (ADS)

    Adhikari, P.; Adhikari, G.; Choi, S.; Ha, C.; Hahn, I. S.; Jeon, EJ; Joo, H. W.; Kang, W. G.; Kim, H. J.; Kim, H. O.; Kim, K. W.; Kim, N. Y.; Kim, S. K.; Kim, Y. D.; Kim, Y. H.; Lee, H. S.; Lee, J. H.; Lee, M. H.; Leonard, D. S.; Li, J.; Oh, S. Y.; Olsen, S. L.; Park, H. K.; Park, H. S.; Park, K. S.; So, J. H.; Yoon, Y. S.

    2016-05-01

    The DAMA experiment has reported an annual-modulation signal in an array of low-background NaI(Tl) scintillating crystals that may be caused by WIMP-nucleon interactions. However, to date there has been no direct confirmation of this result that uses the same taget nuclides. The Korea Invisible Mass Search (KIMS) collaboration has been engaged in an extensive R&D program to grow ultra-low background NaI(Tl) crystals for use as a direct test of the DAMA result using same nuclide targets. Six crystals were grown from different powders in order to understand mechanisms of internal background contaminations and to reduce their effects. Studies of internal backgrounds in these crystals were performed with the ultimate goal of reducing internal background contamination levels to 1 dru at 2 keV.

  12. Kinetics and stoichiometry of coupled Na efflux and Ca influx (Na/Ca exchange) in barnacle muscle cells

    PubMed Central

    1989-01-01

    Coupled Na+ exit/Ca2+ entry (Na/Ca exchange operating in the Ca2+ influx mode) was studied in giant barnacle muscle cells by measuring 22Na+ efflux and 45Ca2+ influx in internally perfused, ATP-fueled cells in which the Na+ pump was poisoned by 0.1 mM ouabain. Internal free Ca2+, [Ca2+]i, was controlled with a Ca-EGTA buffering system containing 8 mM EGTA and varying amounts of Ca2+. Ca2+ sequestration in internal stores was inhibited with caffeine and a mitochondrial uncoupler (FCCP). To maximize conditions for Ca2+ influx mode Na/Ca exchange, and to eliminate tracer Na/Na exchange, all of the external Na+ in the standard Na+ sea water (NaSW) was replaced by Tris or Li+ (Tris-SW or LiSW, respectively). In both Na-free solutions an external Ca2+ (Cao)-dependent Na+ efflux was observed when [Ca2+]i was increased above 10(-8) M; this efflux was half-maximally activated by [Ca2+]i = 0.3 microM (LiSW) to 0.7 microM (Tris-SW). The Cao-dependent Na+ efflux was half-maximally activated by [Ca2+]o = 2.0 mM in LiSW and 7.2 mM in Tris-SW; at saturating [Ca2+]o, [Ca2+]i, and [Na+]i the maximal (calculated) Cao-dependent Na+ efflux was approximately 75 pmol#cm2.s. This efflux was inhibited by external Na+ and La3+ with IC50's of approximately 125 and 0.4 mM, respectively. A Nai-dependent Ca2+ influx was also observed in Tris-SW. This Ca2+ influx also required [Ca2+]i greater than 10(-8) M. Internal Ca2+ activated a Nai-independent Ca2+ influx from LiSW (tracer Ca/Ca exchange), but in Tris-SW virtually all of the Cai-activated Ca2+ influx was Nai-dependent (Na/Ca exchange). Half-maximal activation was observed with [Na+]i = 30 mM. The fact that internal Ca2+ activates both a Cao-dependent Na+ efflux and a Nai- dependent Ca2+ influx in Tris-SW implies that these two fluxes are coupled; the activating (intracellular) Ca2+ does not appear to be transported by the exchanger. The maximal (calculated) Nai-dependent Ca2+ influx was -25 pmol/cm2.s. At various [Na+]i between 6 and 106 m

  13. North America and South America (NA-SA) neuropathy project.

    PubMed

    Pasnoor, Mamatha; Nascimento, Osvaldo J M; Trivedi, Jaya; Wolfe, Gil I; Nations, Sharon; Herbelin, Laura; de Freitas, M G; Quintanilha, Giseli; Khan, Saud; Dimachkie, Mazen; Barohn, Richard

    2013-08-01

    Peripheral neuropathy is a common neurological disorder. There may be important differences and similarities in the diagnosis of peripheral neuropathy between North America (NA) and South America (SA). Neuromuscular databases were searched for neuropathy diagnosis at two North American sites, University of Kansas Medical Center and University of Texas Southwestern Medical Center, and one South American site, Federal Fluminense University in Brazil. All patients were included into one of the six major categories: immune-mediated, diabetic, hereditary, infectious/inflammatory, systemic/metabolic/toxic (not diabetic) and cryptogenic. A comparison of the number of patients in each category was made between North America and South America databases. Total number of cases in North America was 1090 and in South America was 1034 [immune-mediated: NA 215 (19.7%), SA 191 (18%); diabetic: NA 148 (13.5%), SA 236 (23%); hereditary: NA 292 (26.7%), SA 103 (10%); infectious/inflammatory: NA 53 (4.8%), SA 141 (14%); systemic/metabolic/toxic: NA 71 (6.5%), SA 124 (12%); cryptogenic: NA 311 (28.5%), SA 239 (23%)]. Some specific neuropathy comparisons were hereditary neuropathies [Charcot-Marie-Tooth (CMT) cases] in NA 246/292 (84.2%) and SA 60/103 (58%); familial amyloid neuropathy in SA 31/103 (30%) and none in NA. Among infectious neuropathies, cases of human T-lymphotropic virus type 1 (HTLV-1) neuropathy in SA were 36/141(25%), Chagas disease in SA were 13/141(9%) and none for either in NA; cases of neuropathy due to leprosy in NA were 26/53 (49%) and in SA were 39/141(28%). South American tertiary care centers are more likely to see patients with infectious, diabetic and hereditary disorders such as familial amyloid neuropathies. North American tertiary centers are more likely to see patients with CMT. Immune neuropathies and cryptogenic neuropathies were seen equally in North America and South America.

  14. 33 CFR 147.833 - Na Kika FDS safety zone.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Na Kika FDS safety zone. 147.833 Section 147.833 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES SAFETY ZONES § 147.833 Na Kika FDS safety zone. (a) Description....

  15. 33 CFR 147.833 - Na Kika FDS safety zone.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Na Kika FDS safety zone. 147.833 Section 147.833 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES SAFETY ZONES § 147.833 Na Kika FDS safety zone. (a) Description....

  16. Transepithelial Na+ transport and the intracellular fluids: a computer study.

    PubMed

    Civan, M M; Bookman, R J

    1982-01-01

    Computer simulations of tight epithelia under three experimental conditions have been carried out, using the rheogenic nonlinear model of Lew, Ferreira and Moura (Proc. Roy. Soc. London. B 206:53-83, 1979) based largely on the formulation of Koefoed-Johnsen and Ussing (Acta Physiol. Scand. 42: 298-308. 1958). First, analysis of the transition between the short-circuited and open-circuited states has indicated that (i) apical Cl- permeability is a critical parameter requiring experimental definition in order to analyze cell volume regulation, and (ii) contrary to certain experimental reports, intracellular Na+ concentration (ccNa) is expected to be a strong function of transepithelial clamping voltage. Second, analysis of the effects of lowering serosal K+ concentration (csK) indicates that the basic model cannot simulate several well-documented observations; these defects can be overcome, at least qualitatively, by modifying the model to take account of the negative feedback interaction likely to exist between the apical Na+ permeability and ccNa. Third, analysis of the strongly supports the concept that osmotically induced permeability changes in the apical intercellular junctions play a physiological role in conserving the body's stores of NaCl. The analyses also demonstrate that the importance of Na+ entry across the basolateral membrane is strongly dependent upon transepithelial potential, cmNa and csK; under certain conditions, net Na+ entry could be appreciably greater across the basolateral than across the apical membrane.

  17. Adaptation of Tobacco Cells to NaCl 1

    PubMed Central

    Binzel, Marla L.; Hasegawa, Paul M.; Handa, Avtar K.; Bressan, Ray A.

    1985-01-01

    Cell lines of tobacco (Nicotiana tabacum L. var Wisconsin 38) were obtained which are adapted to grow in media with varying concentrations of NaCl, up to 35 grams per liter (599 millimolar). Salt-adapted cells exhibited enhanced abilities to gain both fresh and dry weight in the presence of NaCl compared to cells which were growing in medium without NaCl (unadapted cells). Tolerance of unadapted cells and cells adapted to 10 grams per liter NaCl was influenced by the stage of growth, with the highest degree of tolerance exhibited by cells in the exponential phase. Cell osmotic potential and turgor varied through the growth cycle of unadapted cells and cells at all levels of adaptation, with maximum turgor occurring at approximately the onset of exponential fresh weight accumulation. Adaptation to NaCl led to reduced cell expansion and fresh weight gain, while dry weight gain remained unaffected. This reduction in cell expansion was not due to failure of the cells to maintain turgor since cells adapted to NaCl underwent osmotic adjustment in excess of the change in water potential caused by the addition of NaCl to the medium. Tolerance of the adapted cells, as indicated by fresh or dry weight gain, did not increase proportionately with the increase in turgor. Adaptation of these glycophytic cells to NaCl appears to involve mechanisms which result in an altered relationship between turgor and cell expansion. Images Fig. 3 PMID:16664356

  18. The pea gene NA encodes ent-kaurenoic acid oxidase.

    PubMed

    Davidson, Sandra E; Elliott, Robert C; Helliwell, Chris A; Poole, Andrew T; Reid, James B

    2003-01-01

    The gibberellin (GA)-deficient dwarf na mutant in pea (Pisum sativum) has severely reduced internode elongation, reduced root growth, and decreased leaflet size. However, the seeds develop normally. Two genes, PsKAO1 and PsKAO2, encoding cytochrome P450 monooxygenases of the subfamily CYP88A were isolated. Both PsKAO1 and PsKAO2 had ent-kaurenoic acid oxidase (KAO) activity, catalyzing the three steps of the GA biosynthetic pathway from ent-kaurenoic acid to GA(12) when expressed in yeast (Saccharomyces cerevisiae). In addition to the intermediates ent-7alpha-hydroxykaurenoic acid and GA(12)-aldehyde, some additional products of the pea KAO activity were detected, including ent-6alpha,7alpha-dihydroxykaurenoic acid and 7beta-hydroxykaurenolide. The NA gene encodes PsKAO1, because in two independent mutant alleles, na-1 and na-2, PsKAO1 had altered sequences and the five-base deletion in PsKAO1 associated with the na-1 allele cosegregated with the dwarf na phenotype. PsKAO1 was expressed in the stem, apical bud, leaf, pod, and root, organs in which GA levels have previously been shown to be reduced in na plants. PsKAO2 was expressed only in seeds and this may explain the normal seed development and normal GA biosynthesis in seeds of na plants.

  19. Direct Measurement of {sup 21}Na+{alpha} Stellar Reaction

    SciTech Connect

    Binh, D. N.; Kubono, S.; Yamaguchi, H.; Hayakawa, S.; Hashimoto, T.; Kahl, D.; Teranishi, T.; Iwasa, N.; Kume, N.; Kato, S.; Khiem, L. H.; Tho, N. T.; Wakabayashi, Y.

    2010-08-12

    The measurement of the resonant alpha scattering and the {sup 21}Na({alpha}, p) reaction were performed for the first time in inverse kinematics with the thick target method using a {sup 21}Na radioisotope (RI) beam. This paper reports the current result of alpha scattering measurement and its astrophysics implication.

  20. Moderate temperature rechargeable NaNiS2 cells

    NASA Technical Reports Server (NTRS)

    Abraham, K. M.

    1983-01-01

    A rechargeable sodium battery of the configuration, liquid Na/beta double prime -Al2O3/molten NaAlCl4, NiS2, operating in the temperature range of 170 to 190 C, is described. This battery is capable of delivering or = to 50 W-hr/1b and 1000 deep discharge/charge cycles.

  1. Molecular Mechanisms of Bone 18F-NaF Deposition

    PubMed Central

    Czernin, Johannes; Satyamurthy, Nagichettiar; Schiepers, Christiaan

    2011-01-01

    There is renewed interest in 18F-NaF bone imaging with PET or PET/CT. The current brief discussion focuses on the molecular mechanisms of 18F-NaF deposition in bone and presents model-based approaches to quantifying bone perfusion and metabolism in the context of preclinical and clinical applications of bone imaging with PET. PMID:21078790

  2. Naïve Bayes classification in R

    PubMed Central

    2016-01-01

    Naïve Bayes classification is a kind of simple probabilistic classification methods based on Bayes’ theorem with the assumption of independence between features. The model is trained on training dataset to make predictions by predict() function. This article introduces two functions naiveBayes() and train() for the performance of Naïve Bayes classification. PMID:27429967

  3. Unidirectional Flux Balance of Monovalent Ions in Cells with Na/Na and Li/Na Exchange: Experimental and Computational Studies on Lymphoid U937 Cells

    PubMed Central

    Vereninov, Igor A.; Yurinskaya, Valentina E.; Model, Michael A.; Vereninov, Alexey A.

    2016-01-01

    Monovalent ion traffic across the cell membrane occurs via various pathways. Evaluation of individual fluxes in whole cell is hampered by their strong interdependence. This difficulty can be overcome by computational analysis of the whole cell flux balance. However, the previous computational studies disregarded ion movement of the self-exchange type. We have taken this exchange into account. The developed software allows determination of unidirectional fluxes of all monovalent ions via the major pathways both under the balanced state and during transient processes. We show how the problem of finding the rate coefficients can be solved by measurement of monovalent ion concentrations and some of the fluxes. Interdependence of fluxes due to the mandatory conditions of electroneutrality and osmotic balance and due to specific effects can be discriminated, enabling one to identify specific changes in ion transfer machinery under varied conditions. To test the effectiveness of the developed approach we made use of the fact that Li/Na exchange is known to be an analogue of the coupled Na/Na exchange. Thus, we compared the predicted and experimental data obtained on U937 cells under varied Li+ concentrations and following inhibition of the sodium pump with ouabain. We found that the coupled Na/Na exchange in U937 cells comprises a significant portion of the entire Na+ turnover. The data showed that the loading of the sodium pump by Li/Na exchange involved in the secondary active Li+ transport at 1–10 mM external Li+ is small. This result may be extrapolated to similar Li+ and Na+ flux relationships in erythrocytes and other cells in patients treated with Li+ in therapeutic doses. The developed computational approach is applicable for studying various cells and can be useful in education for demonstrating the effects of individual transporters and channels on ion gradients, cell water content and membrane potential. PMID:27159324

  4. Extending 3-Frequency Na Doppler Lidar Wind and Temperature Measurements into Lower Atmosphere with Na Double-Edge Magneto-Optic Filters (Na-DEMOF)

    NASA Astrophysics Data System (ADS)

    Huang, W.; Chu, X.; Wiig, J.; Williams, B. P.; Harrell, S.; She, C.

    2008-12-01

    An important atmospheric process is the wave coupling among different layers. It is crucial to trace waves from their source regions in the lower atmosphere to their dissipation regions in the middle and upper atmosphere. This requires the profiling of wind and temperature simultaneously from the lower to the upper atmosphere. Utilizing Doppler shift and Doppler broadening effects, various types of Doppler lidars can measure wind and temperature in different atmospheric regions. However, none of the single lidars is able to profile both variables throughout the atmosphere. Resonance fluorescence Na Doppler lidars measure wind and temperature simultaneously in the mesosphere and lower thermosphere. They have made significant contributions to the study of wave dynamics. Unfortunately, their measurements are limited to 80-105 km where the trace gas Na atoms are available. We proposed to incorporate a Na double-edge magneto-optic filter (Na-DEMOF) into the receiver of a 3-frequency Na Doppler lidar to extend its wind and temperature measurements into the lower atmosphere. Two prototypes based on cold- and hot-cell designs were constructed and characterized with laboratory tests. The hot-cell filter showed superior performances than the cold-cell containing buffer gas. The hot-cell Na-DEMOF was also successfully modeled by quantum mechanics calculations. Lidar simulations were conducted for analysis of measurement errors in the altitude range of 15-50 km with the hot-cell filter developed. Field test using the hot-cell Na-DEMOF with the Colorado State University Na lidar is under its way and the initial results will be reported and compared to lidar simulation.

  5. Unidirectional Flux Balance of Monovalent Ions in Cells with Na/Na and Li/Na Exchange: Experimental and Computational Studies on Lymphoid U937 Cells.

    PubMed

    Vereninov, Igor A; Yurinskaya, Valentina E; Model, Michael A; Vereninov, Alexey A

    2016-01-01

    Monovalent ion traffic across the cell membrane occurs via various pathways. Evaluation of individual fluxes in whole cell is hampered by their strong interdependence. This difficulty can be overcome by computational analysis of the whole cell flux balance. However, the previous computational studies disregarded ion movement of the self-exchange type. We have taken this exchange into account. The developed software allows determination of unidirectional fluxes of all monovalent ions via the major pathways both under the balanced state and during transient processes. We show how the problem of finding the rate coefficients can be solved by measurement of monovalent ion concentrations and some of the fluxes. Interdependence of fluxes due to the mandatory conditions of electroneutrality and osmotic balance and due to specific effects can be discriminated, enabling one to identify specific changes in ion transfer machinery under varied conditions. To test the effectiveness of the developed approach we made use of the fact that Li/Na exchange is known to be an analogue of the coupled Na/Na exchange. Thus, we compared the predicted and experimental data obtained on U937 cells under varied Li+ concentrations and following inhibition of the sodium pump with ouabain. We found that the coupled Na/Na exchange in U937 cells comprises a significant portion of the entire Na+ turnover. The data showed that the loading of the sodium pump by Li/Na exchange involved in the secondary active Li+ transport at 1-10 mM external Li+ is small. This result may be extrapolated to similar Li+ and Na+ flux relationships in erythrocytes and other cells in patients treated with Li+ in therapeutic doses. The developed computational approach is applicable for studying various cells and can be useful in education for demonstrating the effects of individual transporters and channels on ion gradients, cell water content and membrane potential. PMID:27159324

  6. Feasibility study for a secondary Na/S battery

    NASA Technical Reports Server (NTRS)

    Abraham, K. M.; Schiff, R.; Brummer, S. B.

    1979-01-01

    The feasibility of a moderate temperature Na battery was studied. This battery is to operate at a temperature in the range of 100-150 C. Two kinds of cathode were investigated: (1) a soluble S cathode consisting of a solution of Na2Sn in an organic solvent and (2) an insoluble S cathode consisting of a transition metal dichalcogenide in contact with a Na(+)ion conducting electrolyte. Four amide solvents, dimethyl acetamide, diethyl acetamide, N-methyl acetamide and acetamide, were investigated as possible solvents for the soluble S cathode. Results of stability and electrochemical studies using these solvents are presented. The dialkyl substituted amides were found to be superior. Although the alcohol 1,3-cyclohexanediol was found to be stable in the presence of Na2Sn at 130 C, its Na2Sn solutions did not appear to have suitable electrochemical properties.

  7. Trisodium citrate, Na3(C6H5O7)

    PubMed Central

    Rammohan, Alagappa; Kaduk, James A.

    2016-01-01

    The crystal structure of anhydrous tris­odium citrate, Na3(C6H5O7), has been solved and refined using synchrotron X-ray powder diffraction data, and optimized using density functional theory (DFT). There are two independent five-coordinate Na+ and one six-coordinate Na+ cations in the asymmetric unit. The [NaO5] and [NaO6] polyhedra share edges and corners to form a three-dimensional framework. There are channels parallel to the a and b axes in which the remainder of the citrate anions reside. The only hydrogen bonds are an intra­molecular one between the hy­droxy group and one of the terminal carboxyl­ate O atoms and an intermolecular one between a methylene group and the hydroxyl O atom. PMID:27308044

  8. NaCl-induced accelerated oxidation of chromium

    SciTech Connect

    Shinata, Y.; Nishi, Y.

    1986-10-01

    This paper describes new phenomena about chloride-induced ;accelerated oxidation of chromium. Thermal analysis was adopted to examine the oxidation, which was studied particularly in the case of NaCl. The presence of NaCl remarkably accelerates the oxidation of chromium. The process occurs below the melting point of NaCl, and the main reaction product is Cr/sub 2/O/sub 3/. In the accelerated oxidation NaCl plays a catalytic role because it is not consumed significantly in the process. DTA analysis reveals that the heat of reaction also accelerates the rate of oxidation, especially at an early stage of the reaction. The accelerated oxidation takes place similarly under the presence of chlorides other than NaCl, but the oxidation rate depends on the kind of salt. Therefore the Cl/sup -/ anion plays an important role in the process, while the nature of the cation affects the rate of acceleration.

  9. DIANA NaI-Detector Energy Calibration

    NASA Astrophysics Data System (ADS)

    O'Connor, Kyle; Elofson, David; Lewis, Codie; O'Brien, Erin; Buggelli, Kelsey; Miller, Nevin; O'Rielly, Grant; Maxtagg Collaboration

    2014-09-01

    The DIANA detector is being used for measurements of near threshold pion photoproduction and high-energy nuclear Compton scattering being performed at the MAX-lab tagged photon facility in Lund, Sweden. Accurate energy calibrations are essential for determining the final results from both of these experiments. An energy calibration has been performed for DIANA, a single-crystal, large-volume, NaI detector. This calibration was made by placing the detector directly in the tagged photon beam with energies from 145 to 165 MeV and fitting the detector response to the known photon energies. The DIANA crystal is instrumented with 19 PMTs, pedestal corrections were applied and the PMTs were gain matched in order to combine the readout value from each PMT and determine the final detector response. This response was fitted to the tagged photon energies to provide the final energy calibration. The calibrations were performed with two triggers; one from the detector itself and one provided by the photon tagger. The quality of the final calibration fit and the energy resolution of the detector, σ ~ 2 . 4 MeV, will be shown.

  10. Endurance testing with Li/Na electrolyte

    SciTech Connect

    Ong, E.T.; Remick, R.J.; Sishtla, C.I.

    1996-12-31

    The Institute of Gas Technology (IGT), under subcontract to M-C Power Corporation under DOE funding, has been operating bench-scale fuel cells to investigate the performance and endurance issues of the Li/Na electrolyte because it offers higher ionic conductivity, higher exchange current densities, lower vapor pressures, and lower cathode dissolution rates than the Li/K electrolyte. These cells have continued to show higher performance and lower decay rates than the Li/K cells since the publication of our two previous papers in 1994. In this paper, test results of two long-term 100-cm{sup 2} bench scale cells are discussed. One cell operated continuously at 160 mA/cm{sup 2} for 17,000 hours with reference gases (60H{sub 2}/20CO{sub 2}/20H{sub 2}O fuel at 75% utilization and 30CO{sub 2}/70 air oxidant humidified at room temperature at 50% utilization). The other cell operated at 160 mA/cm{sup 2} for 6900 hours at 3 atm with system gases (64H{sub 2}/16CO{sub 2}/20H{sub 2}O at 75% utilization and an M-C Power system-defined oxidant at 40% utilization). Both cells have shown the highest performance and longest endurance among IGT cells operated to date.

  11. Genome Sequences of Cupriavidus metallidurans Strains NA1, NA4, and NE12, Isolated from Space Equipment

    PubMed Central

    Monsieurs, Pieter; Mijnendonckx, Kristel; Provoost, Ann; Venkateswaran, Kasthuri; Ott, C. Mark; Leys, Natalie

    2014-01-01

    Cupriavidus metallidurans NA1, NA4, and NE12 were isolated from space and spacecraft-associated environments. Here, we report their draft genome sequences with the aim of gaining insight into their potential to adapt to these environments. PMID:25059868

  12. Production of Secondary Radioactive 21Na Beam for the Study of 21Na(α,p)24Mg Stellar Reaction

    NASA Astrophysics Data System (ADS)

    Binh, Dam Nguyen; Khiem, Le Hong; Kubono, S.; Yamaguchi, H.; Wakabayashi, Y.; Hayakawa, S.; Kim, A.

    2008-04-01

    The availability of radioactive beams has produced great opportunities for advances in our understanding of the nucleosynthesis occurring in stellar explosions such as novae, X-ray burst and supernovae. By using an in-flight low-energy radioisotope beam separator (CRIB) at Center for Nuclear Study (CNS), University of Tokyo, we have successfully produced the 21Na proton-rich beam for the study of 21Na(α,p)24Mg reaction which is related to the astrophysically important production of 22Na in the stellar explosive environments. Since it is the first time when this reaction is studied experimentally, we have performed a test experiment to produce the 21Na beam and to estimate the feasibility of the experimental study of 21Na(α,p)24Mg reaction.

  13. Brefeldin A inhibition of apical Na+ channels in epithelia.

    PubMed

    Fisher, R S; Grillo, F G; Sariban-Sohraby, S

    1996-01-01

    Brefeldin A (BFA) is used to probe trafficking of proteins through the central vacuolar system (CVS) in a variety of cells. Transepithelial Na+ transport by high-resistance epithelia, such as A6 cultured cells, is inhibited by BFA. Apical Na+ channels, as well as basolateral pumps and K+ channels, are complex proteins that probably traverse the CVS for routing to the plasma membrane. BFA (5 micrograms/ml) decreases transepithelial Na+ current near zero and increases resistance reversibly after 4 h. Longer exposures are toxic. When tissues were treated for 20 h with 0.2 microgram/ml BFA, Na+ transport also was reversibly inhibited. Using noise analysis, we found that BFA drastically reduced apical Na+ channel density. The increase in single channel current was consistent with cell hyperpolarization. After apical permeabilization with nystatin, changes in transepithelial current reflect changes in basolateral membrane transport. Transport at this membrane was inhibited by ouabain and cycloheximide, but not by BFA. After BFA, aldosterone was ineffective, suggesting that an intact CVS is required for stimulation by this hormone. Thus BFA inhibition of Na+ transport is localized at the apical membrane. Implications for channel turnover as a mechanism for regulating the Na+ transport rate are discussed.

  14. Hormonal regulation of Na -K -ATPase in cultured epithelial cells

    SciTech Connect

    Johnson, J.P.; Jones, D.; Wiesmann, W.P.

    1986-08-01

    Aldosterone and insulin stimulate Na transport through mechanisms involving protein synthesis. Na -K -ATPase has been implicated in the action of both hormones. The authors examined the effect of aldosterone and insulin on Na -K -ATPase in epithelial cells in culture derived from toad urinary bladder (TB6C) and toad kidney (A6). Aldosterone, but not insulin, increases short-circuit current (I/sub sc/) in TB6C cells. Aldosterone increases Na -K -(TSP)ATPase activity after 18 h of incubation, but no effect can be seen at 3 and 6 h. Amiloride, which inhibits aldosterone-induced increases in I/sub sc/, has no effect on either basal or aldosterone stimulated enzyme activity. Both aldosterone and insulin increase I/sub sc/ in A6 cells and when added together are synergistic. Aldosterone stimulates enzyme activity in A6 cells, but insulin alone has no effect. However, aldosterone and insulin together stimulate enzyme activity more than aldosterone alone. It appears that stimulation of Na -K -ATPase activity is involved in aldosterone action in both cell lines but does not appear to be due to increased Na entry, since enhanced enzyme activity is not inhibited by amiloride. In contrast, insulin alone has no direct effect on Na -K -ATPase, although the increased enzyme activity following both agents in combination may explain their synergism on I/sub sc/.

  15. Rat hepatocytes exhibit basolateral Na+/HCO/sub 3/- cotransport

    SciTech Connect

    Renner, E.L.; Lake, J.R.; Scharschmidt, B.F.; Zimmerli, B.; Meier, P.J.

    1989-04-01

    Primary cultures and plasma membrane vesicles were used to characterize Na+ and HCO3- transport by rat hepatocytes. Na+ uptake into hepatocytes was stimulated approximately 10-fold by 25 mM extracellular HCO3-.HCO3--stimulated Na+ uptake was saturable, abolished by 4-acetamido-4'-isothiocyano-2,2'-disulfonic acid stilbene (SITS), and unaffected by amiloride or Cl- removal. Neither propionate nor acetate reproduced this effect of HCO3-. 22Na efflux from preloaded hepatocytes was similarly increased approximately 10-fold by an in greater than out HCO3- concentration gradient. 22Na efflux was also increased by valinomycin and an in greater than out K+ concentration gradient in the presence but not absence of HCO3-. Intracellular pH (pHi) measured with the pH-sensitive fluorochrome 2',7'-bis-(2-carboxyethyl)-5-(and 6-)carboxyfluorescein (BCECF) decreased at a rate of 0.227 (+/- 0.074 SEM) pH units/min when extracellular HCO3- concentration was lowered from 25 to 5 mM at constant PCO2. This intracellular acidification rate was decreased 50-60% in the absence of Na+ or presence of SITS, and was unaffected by amiloride or Cl- removal. Membrane hyperpolarization produced by valinomycin and an in greater than out K+ concentration gradient caused pHi to fall; the rate of fall was decreased 50-70% by Na+ removal or SITS, but not amiloride. An inside positive K+ diffusion potential and a simultaneous out greater than in HCO3- gradient produced a transient 4,4'-diisothiocyano-2,2' disulfonic acid stilbene (DIDS) sensitive, amiloride-insensitive 22Na accumulation in basolateral but not canalicular membrane vesicles. Rat hepatocytes thus exhibit electrogenic basolateral Na+/HCO3- cotransport.

  16. Phyla- and Subtype-Selectivity of CgNa, a Na+ Channel Toxin from the Venom of the Giant Caribbean Sea Anemone Condylactis Gigantea

    PubMed Central

    Billen, Bert; Debaveye, Sarah; Béress, Lászlo; Tytgat, Jan

    2010-01-01

    Because of their prominent role in electro-excitability, voltage-gated sodium (NaV) channels have become the foremost important target of animal toxins. These toxins have developed the ability to discriminate between closely related NaV subtypes, making them powerful tools to study NaV channel function and structure. CgNa is a 47-amino acid residue type I toxin isolated from the venom of the Giant Caribbean Sea Anemone Condylactis gigantea. Previous studies showed that this toxin slows the fast inactivation of tetrodotoxin-sensitive NaV currents in rat dorsal root ganglion neurons. To illuminate the underlying NaV subtype-selectivity pattern, we have assayed the effects of CgNa on a broad range of mammalian isoforms (NaV1.2–NaV1.8) expressed in Xenopus oocytes. This study demonstrates that CgNa selectively slows the fast inactivation of rNaV1.3/β1, mNaV1.6/β1 and, to a lesser extent, hNaV1.5/β1, while the other mammalian isoforms remain unaffected. Importantly, CgNa was also examined on the insect sodium channel DmNaV1/tipE, revealing a clear phyla-selectivity in the efficacious actions of the toxin. CgNa strongly inhibits the inactivation of the insect NaV channel, resulting in a dramatic increase in peak current amplitude and complete removal of fast and steady-state inactivation. Together with the previously determined solution structure, the subtype-selective effects revealed in this study make of CgNa an interesting pharmacological probe to investigate the functional role of specific NaV channel subtypes. Moreover, further structural studies could provide important information on the molecular mechanism of NaV channel inactivation. PMID:21833172

  17. Contributions of cellular leak pathways to net NaHCO3 and NaCl absorption.

    PubMed Central

    Preisig, P A; Alpern, R J

    1989-01-01

    Proton and formic acid permeabilities were measured in the in vivo microperfused rat proximal convoluted tubule by examining the effect on intracellular pH when [H] and/or [formic acid] were rapidly changed in the luminal or peritubular fluids. Apical and basolateral membrane H permeabilities were 0.52 +/- 0.07 and 0.67 +/- 0.18 cm/s, respectively. Using these permeabilities we calculate that proton backleak from the luminal fluid to cell does not contribute significantly to net proton secretion in the early proximal tubule, but may contribute in the late proximal tubule. Apical and basolateral membrane formic acid permeabilities measured at extracellular pH 6.62 were 4.6 +/- 0.5 X 10(-2) and 6.8 +/- 1.5 X 10(-2) cm/s, respectively. Control studies demonstrated that the formic acid permeabilities were not underestimated by either the simultaneous movement of formate into the cell or the efflux of formic acid across the opposite membrane. The measured apical membrane formic acid permeability is too small to support all of transcellular NaCl absorption in the rat by a mechanism that involves Na/H-Cl/formate transporters operating in parallel with formic acid nonionic diffusion. PMID:2542374

  18. Structure determination in 55-atom Li-Na and Na-K nanoalloys.

    PubMed

    Aguado, Andrés; López, José M

    2010-09-01

    The structure of 55-atom Li-Na and Na-K nanoalloys is determined through combined empirical potential (EP) and density functional theory (DFT) calculations. The potential energy surface generated by the EP model is extensively sampled by using the basin hopping technique, and a wide diversity of structural motifs is reoptimized at the DFT level. A composition comparison technique is applied at the DFT level in order to make a final refinement of the global minimum structures. For dilute concentrations of one of the alkali atoms, the structure of the pure metal cluster, namely, a perfect Mackay icosahedron, remains stable, with the minority component atoms entering the host cluster as substitutional impurities. At intermediate concentrations, the nanoalloys adopt instead a core-shell polyicosahedral (p-Ih) packing, where the element with smaller atomic size and larger cohesive energy segregates to the cluster core. The p-Ih structures show a marked prolate deformation, in agreement with the predictions of jelliumlike models. The electronic preference for a prolate cluster shape, which is frustrated in the 55-atom pure clusters due to the icosahedral geometrical shell closing, is therefore realized only in the 55-atom nanoalloys. An analysis of the electronic densities of states suggests that photoelectron spectroscopy would be a sufficiently sensitive technique to assess the structures of nanoalloys with fixed size and varying compositions.

  19. 23 Na and 17O NMR studies of hyperkagome Na4Ir3O8

    NASA Astrophysics Data System (ADS)

    Shockley, Abigail; Bert, Fabrice; Orain, Jean-Christophe; Okamoto, Yoshihiko; Mendels, Philippe

    2015-03-01

    Na4Ir3O8 is a unique case of a 3D corner sharing triangular lattice which can be decorated with quantum spins. It has spurred a lot of theoretical interest as a spin liquid candidate of a new kind where the Hamiltonian might not be thought in terms of a simple Heisenberg case because of spin orbit coupling on the Ir 5d element. We present a comprehensive set of NMR data taken on both the 23Na and 17O sites. We have found that magnetic freezing of all Ir sites sets in below Tf ~ 7.5K ~ 0 . 019 J with a clear hyperfine field transferred from Ir moments and a drastic decrease of 1 /T1 . Above Tf, physical properties are expected to be a landmark of frustration in this exotic geometry. We will discuss our shift and relaxation data in the temperature range of 300K to 7.5 K in the light of published thermodynamic measurements (Y. Okamotoa et al, PRL 99 137207, 2007 and Y. Singh et al, PRB 88 220413(R), 2013) and comment on their implications for the already existing large body of theoretical work.

  20. α-synuclein assemblies sequester neuronal α3-Na+/K+-ATPase and impair Na+ gradient

    PubMed Central

    Shrivastava, Amulya Nidhi; Redeker, Virginie; Fritz, Nicolas; Pieri, Laura; Almeida, Leandro G; Spolidoro, Maria; Liebmann, Thomas; Bousset, Luc; Renner, Marianne; Léna, Clément; Aperia, Anita; Melki, Ronald; Triller, Antoine

    2015-01-01

    Extracellular α-synuclein (α-syn) assemblies can be up-taken by neurons; however, their interaction with the plasma membrane and proteins has not been studied specifically. Here we demonstrate that α-syn assemblies form clusters within the plasma membrane of neurons. Using a proteomic-based approach, we identify the α3-subunit of Na+/K+-ATPase (NKA) as a cell surface partner of α-syn assemblies. The interaction strength depended on the state of α-syn, fibrils being the strongest, oligomers weak, and monomers none. Mutations within the neuron-specific α3-subunit are linked to rapid-onset dystonia Parkinsonism (RDP) and alternating hemiplegia of childhood (AHC). We show that freely diffusing α3-NKA are trapped within α-syn clusters resulting in α3-NKA redistribution and formation of larger nanoclusters. This creates regions within the plasma membrane with reduced local densities of α3-NKA, thereby decreasing the efficiency of Na+ extrusion following stimulus. Thus, interactions of α3-NKA with extracellular α-syn assemblies reduce its pumping activity as its mutations in RDP/AHC. PMID:26323479

  1. Ecotoxicological evaluation of three deicers (NaCl, NaFo, CMA)-effect on terrestrial organisms.

    PubMed

    Robidoux, P Y; Delisle, C E

    2001-02-01

    The use of chemical deicers such as sodium chloride (NaCl) has increased significantly during the past three decades. Deicers induce metal corrosion and alter the physicochemical properties of soils and water. Environmental damage caused by the use of NaCl has prompted government agencies to find alternative deicers. This article presents a comparative ecotoxicological study of three deicers on soil organisms. Sodium formiate (NaFo) and calcium-magnesium acetate (CMA) are the most interesting commercially available deicers based upon their characteristics and potential toxicity. Organisms used in this study were four species of macrophytes (cress (Lepidium sativum), barley (Ordeum vulgare), red fescue grass (Festuca rubra), Kentucky bluegrass (Poa pratensis)) and an invertebrate (Eisenia fetida). Using standardized and modified methods, the relative toxicity of deicers was CMA < NaFo congruent with NaCl. The results demonstrate that these chemicals could have similar impacts in terrestrial environments since similar quantities of NaFo and greater amounts of CMA are necessary to achieve the same efficiency as NaCl. The toxicity of the tested substances was lower in natural composted soil than in artificial substrate (silica or OECD soil), indicating decreased environmental bioavailability. The response of the organisms changed according to endpoint, species, and soil characteristics (artificial substrate as compared to natural organic soil). The most sensitive endpoint measured was macrophyte growth with Kentucky bluegrass being the most sensitive species.

  2. Robust NaO2 Electrochemistry in Aprotic Na-O2 Batteries Employing Ethereal Electrolytes with a Protic Additive.

    PubMed

    Abate, Iwnetim I; Thompson, Leslie E; Kim, Ho-Cheol; Aetukuri, Nagaphani B

    2016-06-16

    Aprotic metal-oxygen batteries, such as Li-O2 and Na-O2 batteries, are of topical research interest as high specific energy alternatives to state-of-the-art Li-ion batteries. In particular, Na-O2 batteries with NaO2 as the discharge product offer higher practical specific energy with better rechargeability and round-trip energy efficiency when compared to Li-O2 batteries. In this work, we show that the electrochemical deposition and dissolution of NaO2 in Na-O2 batteries is unperturbed by trace water impurities in Na-O2 battery electrolytes, which is desirable for practical battery applications. We find no evidence for the formation of other discharge products such as Na2O2·H2O. Furthermore, the electrochemical efficiency during charge remains near ideal in the presence of trace water in electrolytes. Although sodium anodes react with trace water leading to the formation of a high-impedance solid electrolyte interphase, the increase in discharge overpotential is only ∼100 mV when compared to cells employing nominally anhydrous electrolytes. PMID:27214400

  3. Robust NaO2 Electrochemistry in Aprotic Na-O2 Batteries Employing Ethereal Electrolytes with a Protic Additive.

    PubMed

    Abate, Iwnetim I; Thompson, Leslie E; Kim, Ho-Cheol; Aetukuri, Nagaphani B

    2016-06-16

    Aprotic metal-oxygen batteries, such as Li-O2 and Na-O2 batteries, are of topical research interest as high specific energy alternatives to state-of-the-art Li-ion batteries. In particular, Na-O2 batteries with NaO2 as the discharge product offer higher practical specific energy with better rechargeability and round-trip energy efficiency when compared to Li-O2 batteries. In this work, we show that the electrochemical deposition and dissolution of NaO2 in Na-O2 batteries is unperturbed by trace water impurities in Na-O2 battery electrolytes, which is desirable for practical battery applications. We find no evidence for the formation of other discharge products such as Na2O2·H2O. Furthermore, the electrochemical efficiency during charge remains near ideal in the presence of trace water in electrolytes. Although sodium anodes react with trace water leading to the formation of a high-impedance solid electrolyte interphase, the increase in discharge overpotential is only ∼100 mV when compared to cells employing nominally anhydrous electrolytes.

  4. Characterization and antibacterial activity of silver exchanged regenerated NaY zeolite from surfactant-modified NaY zeolite.

    PubMed

    Salim, Mashitah Mad; Malek, Nik Ahmad Nizam Nik

    2016-02-01

    The antibacterial activity of regenerated NaY zeolite (thermal treatment from cetyltrimethyl ammonium bromide (CTAB)-modified NaY zeolite and pretreatment with Na ions) loaded with silver ions were examined using the broth dilution minimum inhibitory concentration (MIC) method against Escherichia coli (E. coli ATCC 11229) and Staphylococcus aureus (S. aureus ATCC 6538). X-ray diffraction (XRD), attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, field emission scanning electron microscopy (FESEM), energy dispersive X-ray (EDX) and chemical elemental analyses were used to characterize the regenerated NaY and AgY zeolites. The XRD patterns indicated that the calcination and addition of silver ions on regenerated NaY zeolite did not affect the structure of the regenerated NaY zeolite as the characteristic peaks of the NaY zeolite were retained, and no new peaks were observed. The regenerated AgY zeolite showed good antibacterial activity against both bacteria strains in distilled water, and the antibacterial activity of the samples increased with increasing Ag loaded on the regenerated AgY zeolite; the regenerated AgY zeolite was more effective against E. coli than S. aureus. However, the antibacterial activity of the regenerated AgY was not effective in saline solution for both bacteria. The study showed that CTAB-modified NaY zeolite materials could be regenerated to NaY zeolite using thermal treatment (550°C, 5h) and this material has excellent performance as an antibacterial agent after silver ions loading. PMID:26652350

  5. Determinants of substrate and cation transport in the human Na+/dicarboxylate cotransporter NaDC3.

    PubMed

    Schlessinger, Avner; Sun, Nina N; Colas, Claire; Pajor, Ana M

    2014-06-13

    Metabolic intermediates, such as succinate and citrate, regulate important processes ranging from energy metabolism to fatty acid synthesis. Cytosolic concentrations of these metabolites are controlled, in part, by members of the SLC13 gene family. The molecular mechanism underlying Na(+)-coupled di- and tricarboxylate transport by this family is understood poorly. The human Na(+)/dicarboxylate cotransporter NaDC3 (SLC13A3) is found in various tissues, including the kidney, liver, and brain. In addition to citric acid cycle intermediates such as α-ketoglutarate and succinate, NaDC3 transports other compounds into cells, including N-acetyl aspartate, mercaptosuccinate, and glutathione, in keeping with its dual roles in cell nutrition and detoxification. In this study, we construct a homology structural model of NaDC3 on the basis of the structure of the Vibrio cholerae homolog vcINDY. Our computations are followed by experimental testing of the predicted NaDC3 structure and mode of interaction with various substrates. The results of this study show that the substrate and cation binding domains of NaDC3 are composed of residues in the opposing hairpin loops and unwound portions of adjacent helices. Furthermore, these results provide a possible explanation for the differential substrate specificity among dicarboxylate transporters that underpin their diverse biological roles in metabolism and detoxification. The structural model of NaDC3 provides a framework for understanding substrate selectivity and the Na(+)-coupled anion transport mechanism by the human SLC13 family and other key solute carrier transporters.

  6. Characterization and antibacterial activity of silver exchanged regenerated NaY zeolite from surfactant-modified NaY zeolite.

    PubMed

    Salim, Mashitah Mad; Malek, Nik Ahmad Nizam Nik

    2016-02-01

    The antibacterial activity of regenerated NaY zeolite (thermal treatment from cetyltrimethyl ammonium bromide (CTAB)-modified NaY zeolite and pretreatment with Na ions) loaded with silver ions were examined using the broth dilution minimum inhibitory concentration (MIC) method against Escherichia coli (E. coli ATCC 11229) and Staphylococcus aureus (S. aureus ATCC 6538). X-ray diffraction (XRD), attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, field emission scanning electron microscopy (FESEM), energy dispersive X-ray (EDX) and chemical elemental analyses were used to characterize the regenerated NaY and AgY zeolites. The XRD patterns indicated that the calcination and addition of silver ions on regenerated NaY zeolite did not affect the structure of the regenerated NaY zeolite as the characteristic peaks of the NaY zeolite were retained, and no new peaks were observed. The regenerated AgY zeolite showed good antibacterial activity against both bacteria strains in distilled water, and the antibacterial activity of the samples increased with increasing Ag loaded on the regenerated AgY zeolite; the regenerated AgY zeolite was more effective against E. coli than S. aureus. However, the antibacterial activity of the regenerated AgY was not effective in saline solution for both bacteria. The study showed that CTAB-modified NaY zeolite materials could be regenerated to NaY zeolite using thermal treatment (550°C, 5h) and this material has excellent performance as an antibacterial agent after silver ions loading.

  7. On the structure and chemical bonding of Si62- and Si62- in NaSi6- upon Na+ coordination

    NASA Astrophysics Data System (ADS)

    Zubarev, Dmitry Yu.; Alexandrova, Anastassia N.; Boldyrev, Alexander I.; Cui, Li-Feng; Li, Xi; Wang, Lai-Sheng

    2006-03-01

    Photoelectron spectroscopy was combined with ab initio calculations to elucidate the structure and bonding in Si62- and NaSi6-. Well-resolved electronic transitions were observed in the photoelectron spectra of Si6- and NaSi6- at three photon energies (355, 266, and 193nm). The spectra of NaSi6- were observed to be similar to those of Si6- except that the electron binding energies of the former are lower, suggesting that the Si6 motif in NaSi6- is structurally and electronically similar to that in Si6-. The electron affinities of Si6 and NaSi6 were measured fairly accurately to be 2.23±0.03eV and 1.80±0.05eV, respectively. Global minimum structure searches for Si62- and NaSi6- were performed using gradient embedded genetic algorithm followed by B3LYP, MP2, and CCSD(T) calculations. Vertical electron detachment energies were calculated for the lowest Si6- and NaSi6- structures at the CCSD(T)/6-311+G(2df ), ROVGF/6-311+G(2df), UOVGF/6-311+G(2d), and time-dependent B3LYP/6-311+G(2df) levels of theory. Experimental vertical detachment energies were used to verify the global minimum structure for NaSi6-. Though the octahedral Si62-, analogous to the closo form of borane B6H62-, is the most stable form for the bare hexasilicon dianion, it is not the kernel for the NaSi6- global minimum. The most stable isomer of NaSi6- is based on a Si62- motif, which is distorted into C2v symmetry similar to the ground state structure of Si6-. The octahedral Si62- coordinated by a Na+ is a low-lying isomer and was also observed experimentally. The chemical bonding in Si62- and NaSi6- was understood using natural bond orbital, molecular orbital, and electron localization function analyses.

  8. Na double-edge magneto-optic filter for Na lidar profiling of wind and temperature in the lower atmosphere.

    PubMed

    Huang, Wentao; Chu, Xinzhao; Williams, B P; Harrell, S D; Wiig, Johannes; She, C-Y

    2009-01-15

    A Na double-edge magneto-optic filter is proposed for incorporation into the receiver of a three-frequency Na Doppler lidar to extend its wind and temperature measurements into the lower atmosphere. Two prototypes based on cold- and hot-cell designs were constructed and tested with laser scanning and quantum mechanics modeling. The hot-cell filter exhibits superior performances over the cold-cell filter containing buffer gas. Lidar simulations, metrics, and error analyses show that simultaneous wind and temperature measurements are feasible in the altitude range of 20-50 km using the hot-cell filter and reasonable Na lidar parameters. PMID:19148254

  9. Lattice sites of Na dopants in ZnO

    NASA Astrophysics Data System (ADS)

    Wahl, U.; Correia, J. G.; Amorim, L.; Decoster, S.; da Silva, M. R.; Pereira, L. M. C.

    2016-09-01

    The angular distribution of β ‑ particles emitted by the radioactive isotope 24Na was monitored following implantation into ZnO single crystals at fluences above 5 × 1012 cm‑2 at CERN’s ISOLDE facility. We identified sodium on two distinct sites: on substitutional Zn sites and on interstitial sites that are close to the so-called octahedral site. The interstitial Na was to a large extent already converted to substitutional Na for annealing at 200 °C, from which an activation energy of 0.8–1.3 eV, most likely around 1.2 eV, is estimated for the migration of interstitial Na in ZnO.

  10. Lattice sites of Na dopants in ZnO

    NASA Astrophysics Data System (ADS)

    Wahl, U.; Correia, J. G.; Amorim, L.; Decoster, S.; da Silva, M. R.; Pereira, L. M. C.

    2016-09-01

    The angular distribution of β - particles emitted by the radioactive isotope 24Na was monitored following implantation into ZnO single crystals at fluences above 5 × 1012 cm-2 at CERN’s ISOLDE facility. We identified sodium on two distinct sites: on substitutional Zn sites and on interstitial sites that are close to the so-called octahedral site. The interstitial Na was to a large extent already converted to substitutional Na for annealing at 200 °C, from which an activation energy of 0.8-1.3 eV, most likely around 1.2 eV, is estimated for the migration of interstitial Na in ZnO.

  11. Degradation Of Carbon/Phenolic Composites By NaOH

    NASA Technical Reports Server (NTRS)

    King, H. M.; Semmel, M. L.; Goldberg, B. E.; Clinton, Raymond G., Jr.

    1989-01-01

    Effects of sodium hydroxide contamination level on physical and chemical properties of phenolic resin and carbon/phenolic composites described in report. NaOH degrades both carbon and phenolic components of carbon/phenolic laminates.

  12. VIEW OF CEMETERY SECTION NA (NEW ADDITION), WITH NORTHERN PERIMETER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF CEMETERY SECTION NA (NEW ADDITION), WITH NORTHERN PERIMETER FENCE ALONG LINCOLN BOULEVARD IN FOREGROUND. VIEW TO SOUTH. - San Francisco National Cemetery, 1 Lincoln Boulevard, San Francisco, San Francisco County, CA

  13. VIEW OF CEMETERY SECTIONS NA (NEW ADDITION) AND NAWS (NEW ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF CEMETERY SECTIONS NA (NEW ADDITION) AND NAWS (NEW ADDITION WEST SIDE) ALONG NORTH DRIVE, WITH MAINTENANCE COMPLEX AT LEFT BACKGROUND. VIEW TO SOUTHEAST. - San Francisco National Cemetery, 1 Lincoln Boulevard, San Francisco, San Francisco County, CA

  14. Interpretation of Na-K-Mg relations in geothermal waters

    USGS Publications Warehouse

    Fournier, R.O.

    1990-01-01

    When using a Na-K-???Mg triangular diagram as an aid in the interpretation of a geothermal water, the estimated temperature of last water-rock equilibration may change by as much as 50??C, depending on which of the many Na/K geothermometers one assumes is correct. A particular geothermometer may work well in one place and not in another because of differences in the mineralogy of the phases that are in contact with the reservoir fluid. The position of the full equilibrium line that is used for geothermometry and for assessing degrees of departure from equilibrium also changes as the assumed K/???Mg geothermometer equation changes. The degree of ambiguity can be evaluated by utilizing the results of all the recently published Na/K geothermometers on a single Na-K-???Mg triangular plot.

  15. Tb/Na tobermorite: Thermal behaviour and high temperature products

    SciTech Connect

    Garra, Walter; Marchetti, Fabio; Merlino, Stefano

    2009-06-15

    By heating a sample of Tb/Na tobermorite we obtained a phase which was identified through its X-ray diffraction (XRD) pattern, as terbium silicate apatite. Subsequently this compound has been directly prepared by solid state reaction and we carried out a structural refinement from XRD data in space group P6{sub 3}/m obtaining cell parameters a=9.39199(4) A and c=6.84041(5) A. Terbium silicate apatite heated in melted NaF led to Tb{sub 4}O{sub 7} crystals. - Graphical Abstract: By heating over 900 deg. C Tb/Na tobermorite a terbium silicate apatite was obtained. The same product has been independently prepared and structurally characterized from powder diffraction data. Attempts of crystallizing terbium silicate apatite from melted NaF led to Tb{sub 4}O{sub 7} crystals.

  16. The liquid krypton calorimeter of NA48: First operation results

    NASA Astrophysics Data System (ADS)

    Costantini, F.

    1998-02-01

    The first technical run of the complete NA48 experimental apparatus took place in 1996. The first operation results of the full size liquid Krypton electromagnetic calorimeter as energy resolution and π 0 mass resolution are presented in this paper.

  17. Regulation of Na v channels in sensory neurons.

    PubMed

    Chahine, Mohamed; Ziane, Rahima; Vijayaragavan, Kausalia; Okamura, Yasushi

    2005-10-01

    Voltage-gated Na(+) channels have an essential role in the biophysical properties of nociceptive neurons. Factors that regulate Na(+) channel function are of interest from both pathophysiological and therapeutic perspectives. Increasing evidence indicates that changes in expression or inappropriate modulation of these channels leads to electrical instability of the cell membrane and the inappropriate spontaneous activity that is observed following nerve injury, and that this might contribute to neuropathic pain. The role of Na(v) channels in nociception depends on modulation by factors such as auxiliary beta-subunits, cytoskeletal proteins and the phosphorylation state of neurons. In this review we describe the modulation of Na(v) channels on sensory neurons by auxiliary beta-subunits, protein kinases and cytoskeletal proteins.

  18. Na+ and Rb+ tracer diffusion in alkali halides

    NASA Astrophysics Data System (ADS)

    Beniere, F.; Sen, S. K.

    1991-11-01

    We have undertaken a fundamental study of heterodiffusion of foreign ions in pure single crystals. The present work describes the measurements of the diffusion coefficient of monovalent cations in some alkali halides, namely Na+ and Rb+ into KCl, KBr, NaI and KI. The priority is given to the super-accuracy of the experimental data. The target is to test the validity of the existing theories for calculating the enthalpy and entropy of migration.

  19. Na+ transport by rabbit urinary bladder, a tight epithelium.

    PubMed

    Lewis, S A; Diamond, J M

    1976-08-27

    By in vitro experiments on rabbit bladder, we reassessed the traditional view that mammalian urinary bladder lacks ion transport mechanisms. Since the ratio of actual-to-nominal membrane area in folded epithelia is variable and hard to estimate, we normalized membrane properties to apical membrane capacitance rather than to nominal area (probably 1 muF approximately 1 cm2 actual area). A new mounting technique that virtually eliminates edge damage yielded resistances up to 78,000 omega muF for rabbit bladder, and resistances for amphibian skin and bladder much higher than those usually reported. This technique made it possible to observe a transport-related conductance pathway, and a close correlation between transepithelial conductance (G) and short-circuit current (Isc) in these tight epithelia. G and Isc were increased by mucosal (Na+) [Isc approximately 0 when (Na+) approximately 0], aldosterone, serosal (HCO-3) and high mucosal (H+); were decreased by amiloride, mucosal (Ca++), ouabain, metabolic inhibitors and serosal (H+); and were unaffected by (Cl-) and little affected by antidiuretic hormone (ADH). Physiological variation in the rabbits' dietary Na+ intake caused variations in bladder G and Isc similar to those caused by the expected in vivo changes in aldosterone levels. The relation between G and Isc was the same whether defined by diet changes, natural variation among individual rabbits, or most of the above agents. A method was developed for separately resolving conductances of junctions, basolateral cell membrane, and apical cell membrane from this G--Isc relation. Net Na+ flux equalled Isc. Net Cl- flux was zero on short circuit and equalled only 25% of net Na+ flux in open circuit. Bladder membrane fragments contained a Na+-K+-activated, ouabain-inhibited ATPase. The physiological significance of Na+ absorption against steep gradients in rabbit bladder may be to maintain kidney-generated ion gradients during bladder storage of urine, especially

  20. An empirical NaKCa geothermometer for natural waters

    USGS Publications Warehouse

    Fournier, R.O.; Truesdell, A.H.

    1973-01-01

    An empirical method of estimating the last temperature of water-rock interaction has been devised. It is based upon molar Na, K and Ca concentrations in natural waters from temperature environments ranging from 4 to 340??C. The data for most geothermal waters cluster near a straight line when plotted as the function log ( Na K) + ?? log [ ??? (Ca) Na] vs reciprocal of absolute temperature, where ?? is either 1 3 or 4 3 depending upon whether the water equilibrated above or below 100??C. For most waters tested, the method gives better results than the Na K methods suggested by other workers. The ratio Na K should not be used to estimate temperature if ??? ( MCa) MNa is greater than 1. The Na K values of such waters generally yield calculated temperatures much higher than the actual temperature at which water interacted with the rock. A comparison of the composition of boiling hot-spring water with that obtained from a nearby well (170??C) in Yellowstone Park shows that continued water-rock reactions may occur during ascent of water even though that ascent is so rapid that little or no heat is lost to the country rock, i.e. the water cools adiabatically. As a result of such continued reaction, waters which dissolve additional Ca as they ascend from the aquifer to the surface will yield estimated aquifer temperatures that are too low. On the other hand, waters initially having enough Ca to deposit calcium carbonate during ascent may yield estimated aquifer temperatures that are too high if aqueous Na and K are prevented from further reaction with country rock owing to armoring by calcite or silica minerals. The Na-K-Ca geothermometer is of particular interest to those prospecting for geothermal energy. The method also may be of use in interpreting compositions of fluid inclusions. ?? 1973.