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Sample records for hse dublin mid-leinster

  1. HSE12 implementation in libxc

    SciTech Connect

    Moussa, Jonathan E.

    2013-05-13

    This piece of software is a new feature implemented inside an existing open-source library. Specifically, it is a new implementation of a density functional (HSE, short for Heyd-Scuseria-Ernzerhof) for a repository of density functionals, the libxc library. It fixes some numerical problems with existing implementations, as outlined in a scientific paper recently submitted for publication. Density functionals are components of electronic structure simulations, which model properties of electrons inside molecules and crystals.

  2. HSE's safety assessment principles for criticality safety.

    PubMed

    Simister, D N; Finnerty, M D; Warburton, S J; Thomas, E A; Macphail, M R

    2008-06-01

    The Health and Safety Executive (HSE) published its revised Safety Assessment Principles for Nuclear Facilities (SAPs) in December 2006. The SAPs are primarily intended for use by HSE's inspectors when judging the adequacy of safety cases for nuclear facilities. The revised SAPs relate to all aspects of safety in nuclear facilities including the technical discipline of criticality safety. The purpose of this paper is to set out for the benefit of a wider audience some of the thinking behind the final published words and to provide an insight into the development of UK regulatory guidance. The paper notes that it is HSE's intention that the Safety Assessment Principles should be viewed as a reflection of good practice in the context of interpreting primary legislation such as the requirements under site licence conditions for arrangements for producing an adequate safety case and for producing a suitable and sufficient risk assessment under the Ionising Radiations Regulations 1999 (SI1999/3232 www.opsi.gov.uk/si/si1999/uksi_19993232_en.pdf).

  3. Salmonella dublin abortion in cattle

    PubMed Central

    Hinton, M.

    1973-01-01

    The somatic and flagellar serum agglutinin titre were determined in paired samples obtained from seventy-seven cases of bovine abortion associated with Salmonella dublin infection. The cases could be divided into four serological groups with an active infection being demonstrated in most cases. The serum agglutination test was shown to be a relatively specific diagnostic test but was of more limited value in the retrospective identification of convalescent cases. PMID:4518345

  4. 9 CFR 113.123 - Salmonella Dublin Bacterin.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Inactivated Bacterial Products § 113.123 Salmonella Dublin Bacterin. Salmonella Dublin Bacterin shall be...

  5. Radar Image of Dublin, Ireland

    NASA Image and Video Library

    2017-09-27

    Visualization Date 1994-04-11 This radar image of Dublin, Ireland, shows how the radar distingishes between densely populated urban areas and nearby areas that are relatively unsettled. In the center of the image is the city's natural harbor along the Irish Sea. The pinkish areas in the center are the densely populated parts of the city and the blue/green areas are the suburbs. The two ends of the Dublin Bay are Howth Point, the circular peninsula near the upper right side of the image, and Dun Laoghaire, the point to the south. The small island just north of Howth is called "Ireland's Eye," and the larger island, near the upper right corner of the image is Lambay Island. The yellow/green mountains in the lower left of the image (south) are the Wicklow Mountains. The large lake in the lower left, nestled within these mountains, is the Poulaphouca Reservoir along River Liffey. The River Liffey, the River Dodder and the Tolka River are the three rivers that flow into Dublin. The straight features west of the city are the Grand Canal and the three rivers are the faint lines above and below these structures. The dark X-shaped feature just to the north of the city is the Dublin International Airport. The image was acquired by the Spaceborne Imaging Radar-C/X-band Synthetic Aperture (SIR-C/X-SAR) when it flew aboard the space shuttle Endeavour on April 11, 1994. This area is centered at 53.3 degrees north latitude, 6.2 degrees west longitude. The area shown is approximately 55 kilometers by 42 kilometers (34 miles by 26 miles). The colors are assigned to different frequencies and polarizations of the radar as follows: Red is L-band horizontally transmitted, horizontally received; green is L-band vertically transmitted, vertically received; and blue is C-band vertically transmitted, vertically received. SIR-C/X-SAR, a joint mission of the German, Italian, and the United States space agencies, is part of NASA's Mission to Planet Earth. Credit: NASA/GSFC For more

  6. 9 CFR 113.123 - Salmonella Dublin Bacterin.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Salmonella Dublin Bacterin. 113.123... Inactivated Bacterial Products § 113.123 Salmonella Dublin Bacterin. Salmonella Dublin Bacterin shall be prepared from a culture of Salmonella dublin which has been inactivated and is nontoxic. Each serial...

  7. 9 CFR 113.123 - Salmonella Dublin Bacterin.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Salmonella Dublin Bacterin. 113.123... Inactivated Bacterial Products § 113.123 Salmonella Dublin Bacterin. Salmonella Dublin Bacterin shall be prepared from a culture of Salmonella dublin which has been inactivated and is nontoxic. Each serial...

  8. 9 CFR 113.123 - Salmonella Dublin Bacterin.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Salmonella Dublin Bacterin. 113.123... Inactivated Bacterial Products § 113.123 Salmonella Dublin Bacterin. Salmonella Dublin Bacterin shall be prepared from a culture of Salmonella dublin which has been inactivated and is nontoxic. Each serial...

  9. 9 CFR 113.123 - Salmonella Dublin Bacterin.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Salmonella Dublin Bacterin. 113.123... Inactivated Bacterial Products § 113.123 Salmonella Dublin Bacterin. Salmonella Dublin Bacterin shall be prepared from a culture of Salmonella dublin which has been inactivated and is nontoxic. Each serial...

  10. HSE management standards and stress-related work outcomes.

    PubMed

    Kerr, Robert; McHugh, Marie; McCrory, Mark

    2009-12-01

    The UK Health and Safety Executive's (HSE) Management Standards (MS) approach has been developed to help organizations manage potential sources of work-related stress. Although there is general support for the assessment model adopted by this approach, to date, there has been no empirical investigation of the relationship between the actual MS (as measured by the final revised version of the HSE Indicator Tool) and stress-related work outcomes. To investigate the relationship between the HSE MS and the following stress-related work outcomes: 'job satisfaction', job-related anxiety and depression and errors/near misses. An anonymous cross-sectional questionnaire was distributed by either e-mail or post to all employees within a community-based Health and Social Services Trust. Respondents completed the HSE Indicator Tool, a job-related anxiety and depression scale, a job satisfaction scale and an aggregated measure of the number of errors/near misses witnessed. Associations between the HSE Indicator Tool responses and stress-related work outcomes were analysed with regression statistics. A total of 707 employees completed the questionnaire, representing a low response rate of 29%. Controlling for age, gender and contract type, the HSE MS (as measured by the HSE Indicator Tool) were positively associated with job satisfaction and negatively associated with 'job-related anxiety', 'job-related depression' and 'witnessed errors/near misses'. This study provides empirical evidence to support the use of the MS approach in tackling workplace stress.

  11. Committed HSE management Vs TQM: Is there any difference?

    SciTech Connect

    Aitken, J.D.; McMath, C.R.; Lombardo, G.J.

    1996-11-01

    Safe performance of oilfield service operations at unfamiliar customer installations requires service personnel that are highly trained and motivated. When such operations are made in over sixty countries with an independent, multi-cultural work force, an additional level of difficulty in achieving an improved level of HSE (Health, Safety & Environment) performance is introduced. Recognizing these challenges, one company set out in 1989 to implement a comprehensive HSE management system suited to this environment. The system, described here, was launched with total commitment and participation of all levels of management and was designed to empower the work force rather than force them into compliance. This included a realignment of management priorities to give HSE a primary place along with other management responsibilities. One central theme of the system is a single standard applied to all HSE actions, throughout the world and at all levels of the Company. Thus, for example, all employees including all managers go through the same basic HSE training courses on a regular basis. After six years, a cultural change has taken place, along with a notable reduction in both accident frequency and severity, measured in terms of lost workdays. This reduction in lost workdays is an easily quantifiable cost saving which by far outweighs the total cost of the HSE system implementation. While the HSE management system was designed to specifically meet the needs of the company, the techniques used closely parallel those of Total Quality Management (TQM), which, in the last years, has gained momentum as a {open_quotes}new paradigm{close_quotes} in the HSE field. In this company`s experience, a common sense application of sound management to the HSE process has led to a TQM system.

  12. Space Radar Image of Dublin, Ireland

    NASA Image and Video Library

    1999-04-15

    This radar image of Dublin, Ireland, shows how the radar distinguishes between densely populated urban areas and nearby areas that are relatively unsettled. In the center of the image is the city natural harbor along the Irish Sea.

  13. The HSE Management Standards Indicator Tool: concurrent and construct validity.

    PubMed

    Marcatto, F; Colautti, L; Larese Filon, F; Luis, O; Ferrante, D

    2014-07-01

    The Health & Safety Executive Management Standards Indicator Tool (HSE-MS IT) is a questionnaire commonly used to assess work-related stress risks at an organizational level. A critical factor in determining whether this instrument is actually useful is that higher levels of stress risk in the work-design domains should predict higher levels of stress and stress-related outcomes in workers. Only a few studies, however, have addressed this issue. To test both the concurrent and construct validity of the HSE-MS IT, by relating it with another widely used instrument, the Job Content Questionnaire (JCQ), and by examining its relationships with a set of work-related stress outcomes. An anonymous cross-sectional questionnaire was administered to a sample of employees in an Italian municipality. The questionnaire included the HSE-MS IT, self-reported measures of job satisfaction, job motivation and stress at work, the Satisfaction with Life Scale and the reduced form of the JCQ. A total of 760 out of 779 employees completed the questionnaire. Results showed moderate to strong correlation among the corresponding HSE-MS IT and JCQ scales. Hierarchical regression highlighted the specific contribution of each of the HSE-MS IT scales in predicting three relevant work-related stress outcomes (self-reported stress, job satisfaction and job motivation), after controlling for gender, age and life satisfaction. Our findings consolidated the HSE-MS IT validity and showed the specific sensitivity of its scales to assess different aspects of work-related distress, including self-perception of stress at work. These results can have practical implications for the occupational well-being of employees. © The Author 2014. Published by Oxford University Press on behalf of the Society of Occupational Medicine. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  14. Using the HSE stress indicator tool in a military context.

    PubMed

    Bridger, Robert S; Dobson, Karen; Davison, Hannah

    2016-01-01

    An assessment of the Health and Safety Executive's (HSE) stress indicator tool was conducted to determine whether it was suitable for use with Ministry of Defence (MoD) personnel. A total of 1031 respondents from the Army, Navy, Air Force and MoD civilians completed a questionnaire containing the HSE tool and supplementary measures of work-life balance, engagement, deployment, leave taken and hours of work. Six measures of adverse reaction to the stressors were also reported: perceptions of job stress, job stress and health, psychological strain, fatigue after work, work ability and quality of working life. The stressor scales, particularly the 'demands' and 'relationships' scales, were associated with adverse outcomes as was the work-life balance scale. The HSE tool had some validity when used with MoD personnel, but its content was too narrow. The content validity of the tool can be improved for use in a military context with the addition of a 'work-life balance' scale'. The HSE stress tool was tested with a mixed sample of MoD employees. The ‘Demands and “Relationships” scales were associated with adverse outcomes. An additional Work–Life Balance’ scale improved the content validity, demonstrating the importance of assessing the psychometric qualities of scales when used within particular contexts to ensure validity.

  15. The HSE indicator tool, psychological distress and work ability.

    PubMed

    Guidi, S; Bagnara, S; Fichera, G P

    2012-04-01

    The Health and Safety Executive (HSE) indicator tool is one of the most commonly used tools for assessing the risk of work-related stress. Few studies, however, have investigated whether and how its scales are related to psychological distress or other work-related health outcomes. To investigate the relationship between the HSE indicator tool, psychological distress, as measured by the General Health Questionnaire (GHQ)-12, and work ability, assessed by the Work Ability Index (WAI). All the employees of a mid-sized bank in Italy were asked to fill in an anonymous cross-sectional questionnaire. The questionnaire was structured in four sections: the first one comprised socio-demographic questions and the other three corresponded, respectively, to the Italian translations of the GHQ-12, the HSE and the WAI questionnaires. Four hundred and thirteen employees completed the questionnaire. The response rate was 99%. Controlling for age and gender, the indicator subscales were negatively associated with the adopted measures of psychological distress and work ability. The GHQ score was also highly correlated with the WAI score and able to explain ≈ 47% of its variance. The only subscale that was still significantly associated with the WAI after removing the effect of psychological distress was 'control'. The study presents new evidence for the validity of the HSE indicator tool to estimate the risk of work-related stress and suggests that most but not all the effects of psychosocial conditions on work ability might be mediated by the level of psychological distress induced by these conditions.

  16. Comparing LDA-1/2, HSE03, HSE06 and G₀W₀ approaches for band gap calculations of alloys.

    PubMed

    Pela, R R; Marques, M; Teles, L K

    2015-12-23

    It has long been known that the local density approximation and the generalized gradient approximation do not furnish reliable band gaps, and one needs to go beyond these approximations to reliably describe these properties. Among alternatives are the use of hybrid functionals (HSE03 and HSE06 being popular), the GW approximation or the recently proposed LDA-1/2 method. In this work, we compare rigorously the performance of these four methods in describing the band gaps of alloys, employing the generalized quasi-chemical approach to treat the disorder of the alloy and to obtain judiciously the band gap for the entire compositional range. Zincblende InGaAs and InGaN were chosen as prototypes due to their importance in optoelectronic applications. The comparison between these four approaches was guided both by the agreement between the predicted band gap and the experimental one, and by the demanded computational effort (time and memory). We observed that the HSE06 method provided the most accurate results (in comparison with experiments), whereas, surprisingly, the LDA-1/2 method gave the best compromise between accuracy and computational resources. Due to its low computational cost and good accuracy, we decided to double the supercell used to describe the alloys, and employing LDA-1/2 we observed that the bowing parameter changed remarkably, only agreeing with the measured one for the larger supercell, where LDA-1/2 plays an important role.

  17. Joyce's Political Development and the Aesthetic of "Dubliners"

    ERIC Educational Resources Information Center

    Delany, Paul

    1972-01-01

    Traces James Joyce's political evolution from 1903 to his artistic maturity; suggests the chief elements of a political interpretation of Dubliners''; and argues that Joyce's political conscious derives logically from social questions posed in Dubliners.'' Comment by Gaylord C. LeRoy. (RB)

  18. Space Radar Image of Dublin, Ireland

    NASA Technical Reports Server (NTRS)

    1994-01-01

    This radar image of Dublin, Ireland, shows how the radar distinguishes between densely populated urban areas and nearby areas that are relatively unsettled. In the center of the image is the city's natural harbor along the Irish Sea. The pinkish areas in the center are the densely populated parts of the city and the blue/green areas are the suburbs. The two ends of the Dublin Bay are Howth Point, the circular peninsula near the upper right side of the image, and Dun Laoghaire, the point to the south. The small island just north of Howth is called 'Ireland's Eye,' and the larger island, near the upper right corner of the image is Lambay Island. The yellow/green mountains in the lower left of the image (south) are the Wicklow Mountains. The large lake in the lower left, nestled within these mountains, is the Poulaphouca Reservoir along River Liffey. The River Liffey, the River Dodden and the Tolka River are the three rivers that flow into Dublin. The straight features west of the city are the Grand Canal and the three rivers are the faint lines above and below these structures. The dark X-shaped feature just to the north of the city is the Dublin International Airport. The image was acquired by the Spaceborne Imaging Radar-C/X-band Synthetic Aperture (SIR-C/X-SAR) when it flew aboard the space shuttle Endeavour on April 11, 1994. This area is centered at 53.3 degrees north latitude, 6.2 degrees west longitude. The area shown is approximately 55 kilometers by 42 kilometers (34 miles by 26 miles). The colors are assigned to different frequencies and polarizations of the radar as follows: Red is L-band horizontally transmitted, horizontally received; green is L-band vertically transmitted, vertically received; and blue is C-band vertically transmitted, vertically received. SIR-C/X-SAR, a joint mission of the German, Italian, and the United States space agencies, is part of NASA's Mission to Planet Earth.

  19. Validation of the Italian version of the HSE Indicator Tool.

    PubMed

    Magnavita, N

    2012-06-01

    An Italian version of the Health & Safety Executive's (HSE) Management Standards Revised Indicator Tool (MS-RIT) has been used to monitor the working conditions that may lead to stress. To initially examine the factor structure of the Italian version of the MS-RIT, in comparison with the original UK tool, and to investigate its validity and reliability; second, to study the association between occupational stress and psychological distress. Workers from 17 companies self-completed the MS-RIT and the General Health Questionnaire used to measure the psychological distress while they waited for their periodic examination at the workplace. Factor analysis was employed to ascertain whether the Italian version maintained the original subdivision into seven scales. Odds ratios were calculated to estimate the risk of impairment associated with exposure to stress at the workplace. In total, 748 workers participated; the response rate was 91%. The factor structure of the Italian MS-RIT corresponded partially to the original UK version. The 'demand', 'control', 'role', ' relationship' and 'colleague-support' scales were equivalent to the UK ones. A principal factor, termed ' elasticity', incorporated the UK 'management-support' and 'change' scales. Reliability analysis of the sub-scales revealed Cronbach's alpha values ranging from 0.75 to 0.86. Our findings confirmed the usefulness of the Italian version of the HSE MS-RIT in stress control.

  20. Daedalus in Dublin: A Physicist's Labyrinth

    NASA Astrophysics Data System (ADS)

    O'Connor, Thomas C.

    2014-03-01

    I describe some of the rich physical and natural-philosophy heritage of the urban center of the Irish capital Dublin (first tour) and its environs (second tour), in a two-part excursion that could take between two and eight hours in toto. In terms of history, both tours center around the nineteenth century. The first tour is located in and around Trinity College, and we encounter such personages as William Rowan Hamilton, George Fitzgerald, Ernest Walton, and Erwin Schrödinger, among others. Moving away from Trinity College, the second tour explores some of the periphery of the city. I describe the role of politics, money, and religion in shaping the emergence and development of scientific talent among the Irish people, and consequently the footprint left by physics in the city today, with its numerous sites and names that put Irish physics in an honorable place among the nations.

  1. Molecular determinants of the interaction between Doa1 and Hse1 involved in endosomal sorting.

    PubMed

    Han, Seungsu; Shin, Donghyuk; Choi, Hoon; Lee, Sangho

    2014-03-28

    Yeast Doa1/Ufd3 is an adaptor protein for Cdc48 (p97 in mammal), an AAA type ATPase associated with endoplasmic reticulum-associated protein degradation pathway and endosomal sorting into multivesicular bodies. Doa1 functions in the endosomal sorting by its association with Hse1, a component of endosomal sorting complex required for transport (ESCRT) system. The association of Doa1 with Hse1 was previously reported to be mediated between PFU domain of Doa1 and SH3 of Hse1. However, it remains unclear which residues are specifically involved in the interaction. Here we report that Doa1/PFU interacts with Hse1/SH3 with a moderate affinity of 5 μM. Asn-438 of Doa1/PFU and Trp-254 of Hse1/SH3 are found to be critical in the interaction while Phe-434, implicated in ubiquitin binding via a hydrophobic interaction, is not. Small-angle X-ray scattering measurements combined with molecular docking and biochemical analysis yield the solution structure of the Doa1/PFU:Hse1/SH3 complex. Taken together, our results suggest that hydrogen bonding is a major determinant in the interaction of Doa1/PFU with Hse1/SH3.

  2. Systematic review: work-related stress and the HSE management standards.

    PubMed

    Brookes, K; Limbert, C; Deacy, C; O'Reilly, A; Scott, S; Thirlaway, K

    2013-10-01

    The Health and Safety Executive (HSE) has defined six management standards representing aspects of work that, if poorly managed, are associated with lower levels of employee health and productivity, and increased sickness absence. The HSE indicator tool aims to measure organizations' performance in managing the primary stressors identified by the HSE management standards. The aims of the study are to explore how the HSE indicator tool has been implemented within organizations and to identify contexts in which the tool has been used, its psychometric properties and relationships with alternative measures of well-being and stress. Studies that matched specific criteria were included in the review. Abstracts were considered by two researchers to ensure a reliable process. Full texts were obtained when abstracts met the inclusion criteria. Thirteen papers were included in the review. Using factor analysis and measures of reliability, the studies suggest that the HSE indicator tool is a psychometrically sound measure. The tool has been used to measure work-related stress across different occupational groups, with a clear relationship between the HSE tool and alternative measures of well-being. Limitations of the tool and recommendations for future research are discussed. The HSE indicator tool is a psychometrically sound measure of organizational performance against the HSE management standards. As such it can provide a broad overview of sources of work-related stress within organizations. More research is required to explore the use of the tool in the design of interventions to reduce stress, and its use in different contexts and with different cultural and gender groups.

  3. Investigating traffic light violations by cyclists in Dublin City Centre.

    PubMed

    Richardson, Matthew; Caulfield, Brian

    2015-11-01

    This research examines the behaviour of cyclists in Dublin City with specific regard to red light running. A number of specific research questions are raised by this study. These questions address the impact of different infrastructure types on red light running, as well as the behavioural patterns and demographics of offending cyclists. Two data collection methods were used to gather information on cyclists in Dublin City - an observational survey and an online questionnaire. The observational surveys examined cyclist compliance with different traffic signal systems and the impact of on-road and off-road cycle infrastructure. An online questionnaire was used to get direct feedback from cyclists in Dublin City on the reasons (if any) they decide to commit infringement at traffic lights. With the recent growth of cycling in Dublin City (as well as many other international cities) it is vital to accommodate and manage this growing demand by ensuring the safety and road discipline of cyclists. The next few years will be crucial for the continued development of cycling in Dublin, particularly due to the increasing investment by transport planners in cycle infrastructure. It is therefore important to identify now the main factors which influence cyclist's decisions to break red lights in order to guide local traffic authorities in their efforts to reduce such transgressions. Copyright © 2015 Elsevier Ltd. All rights reserved.

  4. Dublin and Irish politics in the age of Charles Lucas.

    PubMed

    Hill, J

    2015-09-01

    In addition to his contributions to medicine, Charles Lucas had a long career in politics, starting in the 1740s as a guild representative on the lower house of Dublin corporation, and culminating in his election to the Irish House of Commons in 1761. By examining the background in Dublin and Irish politics, this paper explores Lucas' impact on the electorate, and how it was that he was able to win a parliamentary seat in Dublin and retain it for a decade while he campaigned in support of a range of important Patriot issues. Lucas had none of the qualifications that would normally be required for a successful politician. His father held some land, but as a younger son who had to make a living, Charles was apprenticed to a Dublin apothecary. Nor did he have the political connections that might have compensated for a lack of land, wealth, or status. But Lucas possessed other advantages, notably an education that enabled him to read the city's medieval charters, identifying areas where the Dublin freemen had lost 'ancient rights', and some experience of publishing, so that he could appeal to the electorate. Lucas' remarkable political success stemmed from both local circumstances and his own personal qualities.

  5. The State of the Dublin Core Metadata Initiative: April 1999.

    ERIC Educational Resources Information Center

    Weibel, Stuart

    1999-01-01

    At the sixth Dublin Core Metadata Workshop convened in Washington, DC, in November 19998, a work plan was developed to address unresolved issues in resource description. This report summarizes that work plan, highlights the progress that has been made on it and identifies a few significant projects that exemplify this progress. (AEF)

  6. Quality of Family Life and Mortality in Seventeenth Century Dublin

    ERIC Educational Resources Information Center

    Jordan, Thomas E.

    2010-01-01

    Inquiry into the quality of family life in seventeenth century Dublin is an attempt to understand conditions in the second largest city in the British Isles; further, the era was one of convulsions in the body politic, social, and religious. The Scottish James I and VI (1556 1625) determined that the Irish province closest to Scotland, Ulster,…

  7. Jewish Education in Dublin: Organizational Development and Conflicts

    ERIC Educational Resources Information Center

    Taub, David

    2005-01-01

    The aim of this paper is to dwell on the trends in the development of Jewish education in Dublin. The discussion is based on books written about the Jewish community and central figures in it, on interviews with people who were involved in shaping the Jewish education and with others who were familiar with it, on community magazines and documents…

  8. The State of the Dublin Core Metadata Initiative: April 1999.

    ERIC Educational Resources Information Center

    Weibel, Stuart

    1999-01-01

    At the sixth Dublin Core Metadata Workshop convened in Washington, DC, in November 19998, a work plan was developed to address unresolved issues in resource description. This report summarizes that work plan, highlights the progress that has been made on it and identifies a few significant projects that exemplify this progress. (AEF)

  9. Dark interaction of haematoporphyrin and proflavine with Salmonella dublin cells.

    PubMed

    Veljanov, D; Kussovski, V; Radoucheva, T; Najdenski, H; Ilieva, L; Cherepova, N; Voivodov, K; Genov, N

    1994-01-01

    The influence of haematoporphyrin and proflavine on the virulence, survivability, respiratory activity and cell wall ultrastructure of Salmonella dublin cells was studied. There was a decrease in all biological properties investigated, especially when haematoporphyrin was used for dark incubation in comparison with proflavine. The possible clinical use of negatively charged photosensitizers is discussed.

  10. Occurrence of Salmonella enterica serovar Dublin in Austria.

    PubMed

    Allerberger, Franz; Liesegang, Almut; Grif, Katharina; Khaschabi, Daryusch; Prager, Rita; Danzl, Johann; Höck, Franz; Ottl, Josef; Dierich, Manfred P; Berghold, Christian; Neckstaller, Ingeborg; Tschäpe, Helmut; Fisher, Ian

    2003-01-01

    In Austria, Salmonella enterica serovar Dublin, a bovine-adapted serovar, rarely causes human infections. In the year 2000, Austria was within the European mean with an incidence of 0.1 per million inhabitants. Our data show that the vast majority of all Austrian serovar Dublin infections can be traced to two Tyrolian districts. This concentration of cases can be explained by a particularly traditional aspect of cattle farming in Tyrol, the alpine pasture. There is increased risk of cross-infection due to the communal keeping of animals from various farms. Infected cattle are a source of infection for people, and contagion usually occurs from eating beef and drinking cow's milk. Using pulsed-field gel electrophoresis and automated ribotyping, 3 out of 5 available isolates from human infections could be traced to characteristic Tyrolian S. Dublin clones. Bacteriological screening of herds with a known history of S. Dublin infection would be a start to prevent future contamination of alpine pastures through latently infected cattle excreting potentially infectious feces. Bacteriological screening for fecal carriage before the return of cattle from pastures known to be connected with infections could prevent cross-contamination of large mixed herds.

  11. Alternatives to Industrial Work Placement at Dublin Institute of Technology

    ERIC Educational Resources Information Center

    Bates, Catherine; Gamble, Elena

    2011-01-01

    In the current economic crisis, higher education graduates need transferable professional skills more than ever. They need resourcefulness, an ability to work reflectively, a sense of civic awareness and an impressive curriculum vitae. This case study analyses how Dublin Institute of Technology's Programme for Students Learning With Communities…

  12. Principle Paradigms Revisiting the Dublin Core 1:1 Principle

    ERIC Educational Resources Information Center

    Urban, Richard J.

    2012-01-01

    The Dublin Core "1:1 Principle" asserts that "related but conceptually different entities, for example a painting and a digital image of the painting, are described by separate metadata records" (Woodley et al., 2005). While this seems to be a simple requirement, studies of metadata quality have found that cultural heritage…

  13. Quality of Family Life and Mortality in Seventeenth Century Dublin

    ERIC Educational Resources Information Center

    Jordan, Thomas E.

    2010-01-01

    Inquiry into the quality of family life in seventeenth century Dublin is an attempt to understand conditions in the second largest city in the British Isles; further, the era was one of convulsions in the body politic, social, and religious. The Scottish James I and VI (1556 1625) determined that the Irish province closest to Scotland, Ulster,…

  14. Principle Paradigms Revisiting the Dublin Core 1:1 Principle

    ERIC Educational Resources Information Center

    Urban, Richard J.

    2012-01-01

    The Dublin Core "1:1 Principle" asserts that "related but conceptually different entities, for example a painting and a digital image of the painting, are described by separate metadata records" (Woodley et al., 2005). While this seems to be a simple requirement, studies of metadata quality have found that cultural heritage…

  15. Understanding electronic and optical properties of strontium titanate at both PBE and HSE06 levels

    NASA Astrophysics Data System (ADS)

    Yang, Jianhui; Fan, Qiang

    2017-01-01

    The structural parameters, electronic structure and optical properties of strontium titanate have been investigated by the first-principles. Exchange–correlation effects are treated by the generalized gradient approximation(GGA) employing Perdew–Burke–Ernzerhof (PBE) functional and hybrid density functional Heyd-Scuseria-Ernzerhof(HSE06). The direct-band gaps are equal to 2.06 and 3.73 eV under PBE and HSE06 level, respectively. The indirect-band gaps are equal to 1.67 and 3.33 eV under PBE and HSE06 level, respectively. The optical properties including complex dielectric function, absorption coefficient, refractivity and reflectivity index have been calculated. Meanwhile, the origin of the spectral peaks on the basis of the electronic band structures has been interpreted.

  16. Re-Evaluation of HSE DATA in Light of High P-T Partitioning Data: Late Chondritic Addition to Inner Solar System Bodies Not Always Required for HSE

    NASA Technical Reports Server (NTRS)

    Righter, K.

    2015-01-01

    Studies of terrestrial peridotite and martian and achondritic meteorites have led to the conclusion that addition of chondritic material to growing planets or planetesimals, after core formation, occurred on Earth, Moon, Mars, asteroid 4 Vesta, and the parent body of the angritic meteorites. One study even proposed that this was a common process in the final stages of growth. These conclusions are based al-most entirely on the 8 highly siderophile elements (HSE; Re, Au, Pt, Pd, Rh, Ru, Ir, Os), which have been used to argue for late accretion of chondritic material to the Earth after core formation was complete. This idea was originally proposed because the D(metal/silicate) values for the HSE are very high (greater than 10,000), yet their concentration in the terrestrial mantle is too high to be consistent with such high Ds. The HSE in the terrestrial mantle also are present in chondritic relative abundances and hence require similar Ds if this was the result of core-mantle equilibration. The conclusion that late chondritic additions are required for all five of these bodies is based on the chondritic relative abundances of the HSE, as well as their elevated concentrations in the samples. An easy solution is to call upon addition of chondritic material to the mantle of each body, just after core formation; however, in practice this means similar additions of chondritic materials to each body just after core formation which ranges from approximately 4-5 Ma after T(sub 0) for 4 Vesta and the angrites, to 10-25 Ma for Mars, to 35 to 60 Ma for Moon and perhaps the Earth. Since the work of there has been a realization that high PT conditions can lower the partition coefficients of many siderophile elements, indicating that high PT conditions (magma ocean stage) can potentially explain elevated siderophile element abundances. However, detailed high PT partitioning data have been lacking for many of the HSE to evaluate whether such ideas are viable for all four bodies

  17. Comparing LDA-1/2, HSE03, HSE06 and G 0 W 0 approaches for band gap calculations of alloys

    NASA Astrophysics Data System (ADS)

    Pela, R. R.; Marques, M.; Teles, L. K.

    2015-12-01

    It has long been known that the local density approximation and the generalized gradient approximation do not furnish reliable band gaps, and one needs to go beyond these approximations to reliably describe these properties. Among alternatives are the use of hybrid functionals (HSE03 and HSE06 being popular), the GW approximation or the recently proposed LDA-1/2 method. In this work, we compare rigorously the performance of these four methods in describing the band gaps of alloys, employing the generalized quasi-chemical approach to treat the disorder of the alloy and to obtain judiciously the band gap for the entire compositional range. Zincblende InGaAs and InGaN were chosen as prototypes due to their importance in optoelectronic applications. The comparison between these four approaches was guided both by the agreement between the predicted band gap and the experimental one, and by the demanded computational effort (time and memory). We observed that the HSE06 method provided the most accurate results (in comparison with experiments), whereas, surprisingly, the LDA-1/2 method gave the best compromise between accuracy and computational resources. Due to its low computational cost and good accuracy, we decided to double the supercell used to describe the alloys, and employing LDA-1/2 we observed that the bowing parameter changed remarkably, only agreeing with the measured one for the larger supercell, where LDA-1/2 plays an important role.

  18. Ecological policy in oil-gas complexes, HSE MS implementation in oil and gas company

    NASA Astrophysics Data System (ADS)

    Kochetkova, O. P.; Glyzina, T. S.; Vazim, A. A.; Tugutova, S. S.

    2016-09-01

    The paper considers the following issues: HSE MS international standard implementation in oil and gas industry, taking into account international practices; implementation of standards in oil and gas companies; policy in the field of environmental protection and occupational health and safety; achievement of planned indicators and targets in environmental protection and occupational health and safety.

  19. Occurrence of Salmonella enterica serovar Dublin in Austria.

    PubMed

    Allerberger, F; Liesegang, A; Grif, K; Prager, R; Danzl, J; Höck, F; Ottl, J; Dierich, M P; Berghold, C; Neckstaller, I; Tschäpe, H; Fisher, I

    2002-04-01

    In Austria, Salmonella enterica subsp. enterica serovar Dublin, a bovine-adapted serovar, rarely causes infections in humans. In 2000, Austria was within the European mean with an incidence of 0.1 per million inhabitants. Our data show that the vast majority of all serovar Dublin infections (human and non-human) can be traced epidemiologically to two districts in the Tyrol. This concentration of cases can be explained by a particularly traditional aspect of cattle farming in this area, the alpine pasture. There is an increased risk of cross infection due to the communal keeping of animals from various farms. Infected cattle are a source of infection for humans, and transmission usually occurs from eating beef and drinking cows milk. Using pulsed field gel electrophoresis and automated ribotyping, three out of five isolates from human infections could be traced to characteristic Tyrolean Dublin clones. Bacteriological screening for faecal carriage before the transfer of cattle from risk-herds to the alpine pastures and before the return from risk-pastures to the farms would be a possible starting point to prevent cross-contamination of large mixed herds and contamination of pasture through latently infected cattle. Appropriate research is necessary.

  20. Association between raw milk and human Salmonella dublin infection.

    PubMed Central

    Werner, S B; Humphrey, G L; Kamei, I

    1979-01-01

    Between 1971 and 1975 the mean annual incidence of human Salmonella dublin infection in California increased more than five-fold. Investigation of the increase showed an association with exposure to raw milk in 44 out of 113 cases. Of these 44 patients, 35 had used certified raw milk from a single dairy. Faecal swabs confirmed S dublin infection in the dairy herd and the milk, and so a pasteurisation order was issued. S dublin appears to be an unusually invasive and life-threatening salmonella serotype: 65% of isolations were obtained from non-faecal specimens (mainly blood cultures), 89 patients (80%) were admitted to hospital and 22 patients died. Almost three-quarters of the patients were aged 20 or over, and half had serious underlying diseases, particularly leukaemias and lymphomas. Five patients presented with infected vascular lesions that included aneurysms with abscesses and infections of previous arterial graft sites. The public's increasing desire for a "health food" such as raw milk should be tempered with an appreciation of its attendant risk to health. PMID:476402

  1. The Dublin SURGE Project: geochemical baseline for heavy metals in topsoils and spatial correlation with historical industry in Dublin, Ireland.

    PubMed

    Glennon, M M; Harris, P; Ottesen, R T; Scanlon, R P; O'Connor, P J

    2014-04-01

    The Dublin SURGE (Soil Urban Geochemistry) Project is Dublin's first baseline survey of heavy metals and persistent organic pollutants in topsoils and is part of a Europe-wide initiative to map urban geochemical baselines in ten cities. 1,058 samples were collected as part of a stratified random sampling programme in the greater Dublin area to give an overview of baseline conditions in the city. Samples were analysed for 31 inorganic elements including heavy metals. Analysis of results indicates that the concentrations of lead, copper, zinc and mercury are strongly influenced by human activities, with elevated concentrations in the city docklands, inner city and heavy industry areas. Sources of heavy metals in these areas may include historical industry, coal burning, re-use of contaminated soil, modern traffic and leaded paint and petrol. Concentrations of other inorganic elements in topsoil show patterns which are strongly related to regional bedrock parent material. The spatial distributions of heavy metals, in particular Pb and As, are explored in detail with respect to regional geology and the influence of historical industry on soil quality. Exploratory data, geostatistical and correlation analyses suggest that the concentrations of heavy metals tend to increase as the intensity of historical industrial activity increases. In particular, drinks production, power generation, oil/gas/coal, metals and textile historical industries appear to be the contamination source for several heavy metals. The data provide a geochemical baseline relevant to the protection of human health, compliance with environmental legislation, land use planning and urban regeneration.

  2. Report from the International Conference on Dublin Core and Metadata Applications, 2001.

    ERIC Educational Resources Information Center

    Sugimoto, Shigeo; Adachi, Jun; Baker, Thomas; Weibel, Stuart

    This paper describes the International Conference on Dublin Core and Metadata Applications 2001 (DC-2001), the ninth major workshop of the Dublin Core Metadata Initiative (DCMI), which was held in Tokyo in October 2001. DC-2001 was a week-long event that included both a workshop and a conference. In the tradition of previous events, the workshop…

  3. 78 FR 53054 - Radio Broadcasting Services; Chillicothe, Dublin, Hillsboro, and Marion, Ohio

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-28

    ... COMMISSION 47 CFR Part 73 Radio Broadcasting Services; Chillicothe, Dublin, Hillsboro, and Marion, Ohio... document denies an Application for Review filed by the Committee for Competitive Columbus Radio... argued that the reallotment to Dublin could not be implemented because it would violate the local radio...

  4. Natural Isolates of Salmonella enterica Serovar Dublin Carry a Single nadA Missense Mutation

    PubMed Central

    Bergthorsson, Ulfar; Roth, John R.

    2005-01-01

    Nicotinic acid is required by most isolates of Salmonella enterica (serovar Dublin), a pathogen of cattle. A single nadA missense mutation causes the nutritional requirement of all serovar Dublin isolates tested. Models for persistence of this allele are tested and discussed. PMID:15601727

  5. Natural isolates of Salmonella enterica serovar Dublin carry a single nadA missense mutation.

    PubMed

    Bergthorsson, Ulfar; Roth, John R

    2005-01-01

    Nicotinic acid is required by most isolates of Salmonella enterica (serovar Dublin), a pathogen of cattle. A single nadA missense mutation causes the nutritional requirement of all serovar Dublin isolates tested. Models for persistence of this allele are tested and discussed.

  6. Coming to Journalism: A Comparative Case Study of Postgraduate Students in Dublin and Amman

    ERIC Educational Resources Information Center

    O'Boyle, Neil; Knowlton, Steven

    2015-01-01

    This article presents findings from a pilot study of postgraduate journalism students in Dublin and Amman. The study compared professional outlooks and social characteristics of students in both contexts and examined institutional settings. The study finds that journalism students in Dublin and Amman have very similar views on the profession,…

  7. Coming to Journalism: A Comparative Case Study of Postgraduate Students in Dublin and Amman

    ERIC Educational Resources Information Center

    O'Boyle, Neil; Knowlton, Steven

    2015-01-01

    This article presents findings from a pilot study of postgraduate journalism students in Dublin and Amman. The study compared professional outlooks and social characteristics of students in both contexts and examined institutional settings. The study finds that journalism students in Dublin and Amman have very similar views on the profession,…

  8. An inventory of trees in Dublin city centre.

    PubMed

    Ningal, Tine; Mills, Gerald; Smithwick, Pamela

    2010-01-01

    While urban areas are often considered to be comprised chiefly of artificial surfaces, they can contain a substantial portion of green space and a great diversity of natural habitats. These spaces include public parks, private gardens and street trees, all of which can provide valuable environmental services, such as improved air quality. Trees play a particular role in cities as they are often placed along roadsides and in the median strip of busy streets. As such they regulate access to sunshine, restrict airflow, provide shelter, scavenge air pollutants and manage noise at the street level. A tree planting policy can be an important part of a broader environmental strategy aimed at improving the quality of life in urban areas but this requires up-to-date knowledge of the current tree stock, which does not exist for Dublin. This article presents an inventory of trees in Dublin's city centre, defined as the area between the Grand and Royal canals. The results show that there are over 10,000 trees in the study area representing a density of 684 trees km-2 or one tree to approximately every 50 residents of the city centre. The tree canopy extent when in full foliage was nearly 1 km2 in extent or 6% of the study area. A more detailed analysis of those trees planted along streets shows little species variation but clear distinction in the sizes of trees, which is indicative of the age of planting. These data are used to estimate the carbon stored in Dublin's trees.

  9. A Bioengineered Human Skin Equivalent (HSE) for the Evaluation of Protectants

    DTIC Science & Technology

    2006-11-01

    full thickness skin equivalent that has been optimized by addition of various growth factors, such as ascorbic acid, lipids and a PPAR-α agonist. It...has been characterized for morphology, lipid composition and barrier properties and compared to the commercially available skin equivalents...Compared to these, the HSE possesses closer lipid composition and barrier properties to human skin . The morphology shows a highly differentiated epidermis

  10. [Monitoring early toxicity of heavy metals including Hg using a HSE-SEAP reporter gene].

    PubMed

    Yu, Zhan-Jiang; Yang, Qin; Yang, Xiao-Da; Wang, Kui

    2006-08-01

    To develop a cellular assay based on heat shock signal pathway and secreted alkaline phosphatase (SEAP) reporter gene for investigating/predicting the early toxicity of heavy metals on HeLa cells in Chinese traditional medicine (TCM). The pHSE-SEAP plasmid was transfected into HeLa cells to build a HSE-SEAP-HeLa cell model. For validation of the model, the transfected cells were treated by either heating at 42 degrees C for 1 h or incubated with 5 mol x L(-1) CdCl2 for 4 h. Then the cells were covered in complete DMEM culture medium for 48 h and the activity of SEAP (reflecting the cellular level of heat shock protein) in cultural supernatants was measured; meanwhile, cell viability was determined by MTT assays. In addition, the cells were treated by four mercury compounds, HgCl2, merthilate sodium, HgS and cinnabar at the sub-lethal concentrations (determined by MTT assays). Then the heat shock response was detected likewise. Significant level of secreted alkaline phosphatase (SEAP) was found in pHSE-SEAP transfected HeLa cells treated either by heating (42 degrees C) or incubating with CdCl2. The heat shock protein was induced by CdCl2 before decrease of cell viability was observed. All four mercury compounds induced heat shock response in both time and concentration-dependant manner. However, there were big differences among the mercury compounds, suggesting potential differences for early-stage toxicity in vivo. The pHSE-SEAP transfected HeLa cells respond effectively to heat shock and metal stresses, and therefore provide a practical and repeatable assay for investigating/predicting the early toxicity of heavy metals and mineral-containing drugs in TCM.

  11. Male street prostitution in Dublin: a psychological analysis.

    PubMed

    McCabe, Ian; Acree, Michael; O'Mahony, Finbar; McCabe, Jenny; Kenny, Jean; Twyford, Jennifer; Quigley, Karen; McGlanaghy, Edel

    2011-01-01

    This study assessed the mental health characteristics of 12 male street prostitutes (MSPs) in Dublin, with particular regard to issues of homelessness, substance abuse, depression, suicidal ideation, and self-esteem. Participants completed five psychometric tests, which indicated that all of the participants had above average levels of depression and suicidal ideation and low levels of self-esteem. This study found that candidates likely to become MSPs are young males with a combination of factors, including a background of childhood sexual or physical abuse, leaving school early, running away from home, and a dependence on heroin.

  12. Monitoring harm reduction in European prisons via the Dublin Declaration.

    PubMed

    Lines, Rick; Stöver, Heino; Donochoe, Martin C; Lazarus, Jeffrey V

    2009-01-01

    The Dublin Declaration on Partnership to fight HIV/AIDS in Europe and Central Asia is the key policy document on HIV/AIDS in the European Region as a whole Among the Declaration's 33 actions for governments are many that apply to prison populations. Based upon an analysis of these commitments, and a review of the current status of states in meeting those targets, it is clear that the scale-up of HIV/AIDS prevention and treatment programmes and services in prisons lags far behind what is needed, what is available outside of prisons, and what is mandated within the Declaration itself.

  13. The synthesis and crystal structure of LaHSe2O6, a layered, anhydrous selenite

    NASA Astrophysics Data System (ADS)

    Morris, Russell E.; Harrison, William T.; Stucky, Galen D.; Cheetham, Anthony K.

    1992-05-01

    Lanthanum hydrogen selenite, LaHSe2O6, M(sub r), = 393.83, orthorhombic, P(sub c)2(sub 1)b (No. 29), a = 7.139(6) A, b = 19.008(9) A, c = 8.469(9) A, (alpha = 90 deg, beta = 90 deg, gamma = 90 deg, V = 1149.24 cu A, Z = 8, D(sub x) = 4.55 g cu cm, mu = 199.7 cm(-1), lambda (Mo Ka, graphite monochromator) = 0.71073 A, F(000) = 1392, room temperature 298(2) K. Final R = 3.61 percent, wR = 4.21 percent for 1701 observed reflections with I greater than 3 sigma(I)). LaHSe2O6 has been prepared using hydrothermal synthetic techniques and its crystal structure elucidated by single crystal X-ray diffraction. This new structure consists of layers of LaOl0, HSeO3 and SeO3 polyhedra parallel to the ac-place; the layers are interconnected by Se-OH...O-(Se,La) hydrogen bonds.

  14. Children attending addiction treatment services in Dublin, 1990-1999.

    PubMed

    Smyth, Bobby P; O'Brien, Mary

    2004-01-01

    In Europe, adolescent substance misuse increased during the 1990s. Ireland has among the highest rates of substance misuse among schoolchildren in Europe. We sought to describe the socio-demographic and drug misuse profile of children presenting to addiction treatment services in Dublin during the 1990s. Of the 9,874 individuals who sought addiction treatment, 1,953 (20%) were aged less than 18 years. There was a sharp increase in the number of children after 1993. The main drug of abuse was an opiate in 48% of cases. Compared to adults, the children were more likely to be female and less likely to inject. As the decade progressed the proportion of girls increased, injecting was reported more frequently and there was a dramatic rise in heroin misuse. Child heroin users were more likely to be female and to be homeless compared to their adult counterparts. This study highlights the need for a dedicated service for child drug users in Dublin.

  15. Salmonella Dublin patients in Denmark and their distance to cattle farms.

    PubMed

    Funke, Silvia; Anker, Janus C H; Ethelberg, Steen

    2017-03-01

    The Salmonella serotype Dublin is specifically adapted to cattle but may infect humans leading to severe disease. We described human S. Dublin cases and investigated a potential spatial relation between their addresses and cattle farms in Denmark. We extracted S. Dublin patient surveillance data, 2000-2014, and performed descriptive analyses. We geocoded residential and cattle farm addresses and mapped their incidence by region, province and municipality. We used linear correlation and spatial autocorrelation analysis at the municipality level and calculated the direct network distance from the nearest farm to the residential address of cases and 20,000 randomly selected citizens representing the background population. We identified 484 S. Dublin cases, 57% were male, median age 65 years. Seven patients (1%) acquired their infection abroad. The 30 days all-cause mortality was 13%. Overall, cumulative incidence was 8.0 per 100,000 inhabitants. Cattle farms were located predominantly in the western part of the country. Neither visual inspection nor correlation analysis indicated a relationship between municipalities with high incidences of human cases and cattle farms. Global Moran's Index analysis showed municipalities with high incidence of cases to be randomly distributed. We found equal direct network distances between cattle farms and both addresses of S. Dublin cases and the background population. We found S. Dublin infections in Denmark to affect the elderly, be serious and acquired domestically. Our findings indicate that the risk of infection with S. Dublin in Denmark is independent of living in the proximity to cattle farms.

  16. Proflavine-mediated inactivation of Salmonella dublin exposed to visible sunlight in natural fresh water.

    PubMed

    Kussovski, V K; Hristov, A E; Radoucheva, T S

    2001-01-01

    The survival of Salmonella dublin exposed to visible sunlight, and heterotrophic bacteria in freshwater microcosms in the presence and absence of the photosensitizer proflavine, was studied. Enumeration of S. dublin and the heterotrophic bacteria showed that in both illuminated and nonilluminated systems (without proflavine) the bacteria remained viable and culturable for at least 6 days. The optimal proflavine concentration (no effect in the dark and a maximal photoinactivation of salmonellae after irradiation) was 2 mg l(-1). In contrast to S. dublin, the heterotrophic bacteria overcame the initial inhibitory effect of proflavine. The possible use of photosterilization against contamination with pathogenic bacteria in water model ecosystems, is discussed.

  17. Haematoporphyrin and proflavine-sensitized photoinactivation of Salmonella dublin.

    PubMed

    Kussovski, V; Radoucheva, T; Najdenski, H; Cherepova, N

    1995-01-01

    The photosensitive activity of haematoporphyrin (HP) and proflavine (PF) on some biological parameters of Salmonella dublin cells was assessed. The investigations showed a decreased respiratory activity of photosensitized PF bacterial cells, accompanied by lower virulence. HP-treatment and light irradiation of salmonellae did not influence their survival in vitro, which was in contrast to the PF-incubated and irradiated cells. Light irradiation of HP- and PF-treated bacteria did not change their phagocytosis from guinea pig alveolar macrophages. In the presence of visible light the PF-treatment considerably reduced the survival rate and multiplication in alveolar macrophages in comparison with HP-treated and light-exposed bacteria. Correlation was established between the degree of structural damage, as observed by electron microscopy and the level of diminution of the chosen biological parameters, which were more strongly expressed after PF-treatment. PF as a photosensitizer which influences the bacterial genomes and its possible practical use, is discussed.

  18. Attitudes to and use of baby walkers in Dublin.

    PubMed Central

    Laffoy, M.; Fitzpatrick, P.; Jordan, M.; Dowdall, D.

    1995-01-01

    OBJECTIVES: To identify the rate of baby walker use, parental attitudes, and associated injuries. DESIGN: Parents of babies attending clinics for developmental assessment were surveyed by self administered questionnaire about their use, attitudes, and history of injuries associated with walkers. SETTING: Dublin, Ireland. SUBJECTS: Parents of 158 babies. RESULTS: Fifty five per cent of the sample used a walker. The main reasons for doing so included babies' enjoyment of them and the fact that the walker was used for an older sibling. Although none of the users listed safety concerns as a reason to stop using the walker, non-users (45%) did so; 12.5% of the users had at least one walker related injury. CONCLUSIONS: Parents of babies who use a walker perceive them as beneficial. However these babies are placed at unnecessary risk. It behoves all health professionals and child carers to alert parents to these dangers and the sale of walkers should be reviewed. PMID:9346006

  19. Exposure to hydrocarbon concentrations while commuting or exercising in Dublin.

    PubMed

    O'Donoghue, R T; Gill, L W; McKevitt, R J; Broderick, B

    2007-01-01

    In Ireland, several studies have monitored the air pollution due to traffic in both urban and rural environments. However, few studies have attempted to quantify the relative exposure to traffic derived HC pollutants between different modes of commuter transport. In this study, the difference in pollution exposure between bus and cycling commuters on a route in Dublin was compared by sampling for five vehicle related hydrocarbons: benzene, 1,3-butadiene, acetylene, ethane and ethylene. Samples were collected during both morning and afternoon rush hour periods using a fixed speed pump to gain representative concentrations across the whole journey. Journey times were also measured, as were typical breathing rates in order to calculate the overall dose of pollutant inhaled on the journey. Results clearly picked up significantly higher pollutant concentrations in the bus compared to cycling and also revealed elevated concentrations on the congested side of the road compared to the side moving against the traffic. However, when respiration rates and travel times were taken into account to reveal the mass of pollutants inhaled over the course of a journey, the pattern was reversed, showing slightly enhanced levels of hydrocarbons for the cyclist compared to the bus passenger. In addition, the concentrations of these compounds (excluding ethane), were ascertained at playing pitches in the vicinity of a heavily trafficked suburban motorway and in Dublin city centre. Although the concentrations were relatively low at all sites, when breathing rates were taken into consideration, the average inhaled weights of pollutants were, on occasion, higher than those average values observed for both bus and bicycle commuters.

  20. The Dublin Declaration on Maternal Health Care and Anti-Abortion Activism: Examples from Latin America.

    PubMed

    Morgan, Lynn M

    2017-06-01

    The Dublin Declaration on Maternal Healthcare-issued by self-declared pro-life activists in Ireland in 2012-states unequivocally that abortion is never medically necessary, even to save the life of a pregnant woman. This article examines the influence of the Dublin Declaration on abortion politics in Latin America, especially El Salvador and Chile, where it has recently been used in pro-life organizing to cast doubt on the notion that legalizing abortion will reduce maternal mortality. Its framers argue that legalizing abortion will not improve maternal mortality rates, but reproductive rights advocates respond that the Dublin Declaration is junk science designed to preserve the world's most restrictive abortion laws. Analyzing the strategy and impact of the Dublin Declaration brings to light one of the tactics used in anti-abortion organizing.

  1. The Dublin Declaration on Maternal Health Care and Anti-Abortion Activism

    PubMed Central

    2017-01-01

    Abstract The Dublin Declaration on Maternal Healthcare—issued by self-declared pro-life activists in Ireland in 2012—states unequivocally that abortion is never medically necessary, even to save the life of a pregnant woman. This article examines the influence of the Dublin Declaration on abortion politics in Latin America, especially El Salvador and Chile, where it has recently been used in pro-life organizing to cast doubt on the notion that legalizing abortion will reduce maternal mortality. Its framers argue that legalizing abortion will not improve maternal mortality rates, but reproductive rights advocates respond that the Dublin Declaration is junk science designed to preserve the world’s most restrictive abortion laws. Analyzing the strategy and impact of the Dublin Declaration brings to light one of the tactics used in anti-abortion organizing. PMID:28630540

  2. Characterization of HSE sequences in human Hsp40 gene: structural and promoter analysis.

    PubMed

    Hata, M; Ohtsuka, K

    1998-04-01

    We have recently cloned a gene of Hsp40, a human homologue of bacterial DnaJ. Here we describe the structural and promoter analysis of human Hsp40 gene. Analysis of Hsp40 transcripts by 5' and 3' RACE suggested that they have different 3' ends, and primer extension studies revealed that the major transcription initiation site was localized 47 bp upstream of the ATG translation initiation codon. Promoter analysis using deletion derivatives defined a minimal region which was active in response to heat shock. The region contained the consensus heat shock element (HSE) sequences. The factor bound to these sequences was suggested to be a heat shock factor 1 (HSF1) by gel mobility supershift assay. In vivo footprinting and promoter analysis revealed that the HSEs in 5' upstream region of human Hsp40 gene were composed of eight contiguous (A/G)GAAN motifs and were essential for heat shock response. These results indicate that Hsp40 is a real heat shock protein. It is also shown that the HSE found in the first intron might not be the essential element for heat shock response.

  3. Functional Analysis of Drosophila HSP70 Promoter with Different HSE Numbers in Human Cells

    PubMed Central

    Kust, Nadezda; Rybalkina, Ekaterina; Mertsalov, Ilya; Savchenko, Ekaterina; Revishchin, Alexander; Pavlova, Gali

    2014-01-01

    The activation of genetic constructs including the Drosophila hsp70 promoter with four and eight HSE sequences in the regulatory region has been described in human cells. The promoter was shown to be induced at lower temperatures compared to the human hsp70 promoter. The promoter activity increased after a 60-min heat shock already at 38°C in human cells. The promoter activation was observed 24 h after heat shock for the constructs with eight HSEs, while those with four HSEs required 48 h. After transplantation of in vitro heat-shocked transfected cells, the promoter activity could be maintained for 3 days with a gradual decline. The promoter activation was confirmed in vivo without preliminary heat shock in mouse ischemic brain foci. Controlled expression of the Gdnf gene under a Drosophila hsp70 promoter was demonstrated. This promoter with four and eight HSE sequences in the regulatory region can be proposed as a regulated promoter in genetic therapeutic systems. PMID:25101947

  4. Nanoscale variations in 187Os isotopic composition and HSE systematics in a Bultfontein peridotite

    NASA Astrophysics Data System (ADS)

    Wainwright, A. N.; Luguet, A.; Schreiber, A.; Fonseca, R. O. C.; Nowell, G. M.; Lorand, J.-P.; Wirth, R.; Janney, P. E.

    2016-08-01

    Understanding the mineralogical controls on radiogenic chronometers is a fundamental aspect of all geochronological tools. As with other common dating tools, it has become increasingly clear that the Re-Os system can be impacted by multiple mineral formation events. The accessory and micrometric nature of the Re-Os-bearing minerals has made assessing this influence complex. This is especially evident in cratonic peridotites, where long residence times and multiple metasomatic events have created a complex melting and re-enrichment history. Here we investigate a harzburgitic peridotite from the Bultfontein kimberlite (South Africa) which contains sub-micron Pt-Fe-alloy inclusions within base metal sulphides (BMS). Through the combination of the focused ion beam lift-out technique and low blank mass spectrometry we were able to remove and analyse the Pt-Fe-alloy inclusions for their Re-Os composition and highly siderophile element (HSE) systematics. Six repeats of the whole-rock yield 187Os/188Os compositions of 0.10893-0.10965, which correspond to Re depletion model ages (TRD) of 2.69-2.79 Ga. The Os, Ir and Pt concentrations are slightly variable across the different digestions, whilst Pd and Re remain constant. The resulting HSE pattern is typical of cratonic peridotites displaying depleted Pt and Pd. The Pt-Fe-alloys have PUM-like 187Os/188Os compositions of 0.1294 ± 24 (2-s.d.) and 0.1342 ± 38, and exhibit a saw-tooth HSE pattern with enriched Re and Pt. In contrast, their BMS hosts have unradiogenic 187Os/188Os of 0.1084 ± 6 and 0.1066 ± 3, with TRD ages of 2.86 and 3.09 Ga, similar to the whole-rock systematics. The metasomatic origin of the BMS is supported by (i) the highly depleted nature of the mantle peridotite and (ii) their Ni-rich sulphide assemblage. Occurrence of Pt-Fe-alloys as inclusions within BMS grains demonstrates the genetic link between the BMS and Pt-Fe-alloys and argues for formation during a single but continuous event of silicate melt

  5. Re-Os Systematics and HSE Distribution in Metal from Ochansk (H4) Chondrite

    NASA Technical Reports Server (NTRS)

    Smoliar, M. I.; Horan, M. F.; Alexander, C. M. OD.; Walker, R. J.

    2003-01-01

    Previous studies of the Re-Os systematics of chondrites have documented considerable variation in the Re/Os ratios of whole rock samples. For some whole rock chondrites, Re-Os systematics display large deviations from the primitive isochron that are considerably larger than deviations in other isotope systems. Possible interpretation of these facts is that the Re-Os system in chondrites is particularly sensitive to post-formation alteration processes, thus providing a useful tool to examine such processes. Significant variations that have been detected in highly siderophile element (HSE) patterns for ordinary chondrites support this conclusion. We report Re-Os isotope data for metal separates from the Ochansk H4 chondrite coupled with abundance data for Ru, Pd, Ir, and Pt, determined in the same samples by isotope dilution. We chose this meteorite mainly because it is an observed fall with minimal signs of weathering, and its low metamorphic grade (H4) and shock stage (S3).

  6. Genomic Comparison of the Closely-Related Salmonella enterica Serovars Enteritidis, Dublin and Gallinarum

    PubMed Central

    Matthews, T. David; Schmieder, Robert; Silva, Genivaldo G. Z.; Busch, Julia; Cassman, Noriko; Dutilh, Bas E.; Green, Dawn; Matlock, Brian; Heffernan, Brian; Olsen, Gary J.; Farris Hanna, Leigh; Schifferli, Dieter M.; Maloy, Stanley; Dinsdale, Elizabeth A.; Edwards, Robert A.

    2015-01-01

    The Salmonella enterica serovars Enteritidis, Dublin, and Gallinarum are closely related but differ in virulence and host range. To identify the genetic elements responsible for these differences and to better understand how these serovars are evolving, we sequenced the genomes of Enteritidis strain LK5 and Dublin strain SARB12 and compared these genomes to the publicly available Enteritidis P125109, Dublin CT 02021853 and Dublin SD3246 genome sequences. We also compared the publicly available Gallinarum genome sequences from biotype Gallinarum 287/91 and Pullorum RKS5078. Using bioinformatic approaches, we identified single nucleotide polymorphisms, insertions, deletions, and differences in prophage and pseudogene content between strains belonging to the same serovar. Through our analysis we also identified several prophage cargo genes and pseudogenes that affect virulence and may contribute to a host-specific, systemic lifestyle. These results strongly argue that the Enteritidis, Dublin and Gallinarum serovars of Salmonella enterica evolve by acquiring new genes through horizontal gene transfer, followed by the formation of pseudogenes. The loss of genes necessary for a gastrointestinal lifestyle ultimately leads to a systemic lifestyle and niche exclusion in the host-specific serovars. PMID:26039056

  7. Genomic Comparison of the Closely-Related Salmonella enterica Serovars Enteritidis, Dublin and Gallinarum.

    PubMed

    Matthews, T David; Schmieder, Robert; Silva, Genivaldo G Z; Busch, Julia; Cassman, Noriko; Dutilh, Bas E; Green, Dawn; Matlock, Brian; Heffernan, Brian; Olsen, Gary J; Farris Hanna, Leigh; Schifferli, Dieter M; Maloy, Stanley; Dinsdale, Elizabeth A; Edwards, Robert A

    2015-01-01

    The Salmonella enterica serovars Enteritidis, Dublin, and Gallinarum are closely related but differ in virulence and host range. To identify the genetic elements responsible for these differences and to better understand how these serovars are evolving, we sequenced the genomes of Enteritidis strain LK5 and Dublin strain SARB12 and compared these genomes to the publicly available Enteritidis P125109, Dublin CT 02021853 and Dublin SD3246 genome sequences. We also compared the publicly available Gallinarum genome sequences from biotype Gallinarum 287/91 and Pullorum RKS5078. Using bioinformatic approaches, we identified single nucleotide polymorphisms, insertions, deletions, and differences in prophage and pseudogene content between strains belonging to the same serovar. Through our analysis we also identified several prophage cargo genes and pseudogenes that affect virulence and may contribute to a host-specific, systemic lifestyle. These results strongly argue that the Enteritidis, Dublin and Gallinarum serovars of Salmonella enterica evolve by acquiring new genes through horizontal gene transfer, followed by the formation of pseudogenes. The loss of genes necessary for a gastrointestinal lifestyle ultimately leads to a systemic lifestyle and niche exclusion in the host-specific serovars.

  8. Genomic comparison of the closely-related Salmonella enterica serovars enteritidis, dublin and gallinarum

    DOE PAGES

    Matthews, T. David; Schmieder, Robert; Silva, Genivaldo G. Z.; ...

    2015-06-03

    The Salmonella enterica serovars Enteritidis, Dublin, and Gallinarum are closely related but differ in virulence and host range. To identify the genetic elements responsible for these differences and to better understand how these serovars are evolving, we sequenced the genomes of Enteritidis strain LK5 and Dublin strain SARB12 and compared these genomes to the publicly available Enteritidis P125109, Dublin CT 02021853 and Dublin SD3246 genome sequences. We also compared the publicly available Gallinarum genome sequences from biotype Gallinarum 287/91 and Pullorum RKS5078. Using bioinformatic approaches, we identified single nucleotide polymorphisms, insertions, deletions, and differences in prophage and pseudogene content betweenmore » strains belonging to the same serovar. Through our analysis we also identified several prophage cargo genes and pseudogenes that affect virulence and may contribute to a host-specific, systemic lifestyle. These results strongly argue that the Enteritidis, Dublin and Gallinarum serovars of Salmonella enterica evolve by acquiring new genes through horizontal gene transfer, followed by the formation of pseudogenes. As a result, the loss of genes necessary for a gastrointestinal lifestyle ultimately leads to a systemic lifestyle and niche exclusion in the host-specific serovars.« less

  9. Cattle-derived Salmonella enterica serovar Dublin Infections in Red Foxes ( Vulpes vulpes ) in Tyrol, Austria.

    PubMed

    Glawischnig, Walter; Lazar, Judit; Wallner, Alice; Kornschober, Christian

    2017-01-31

    Salmonella enterica serovar Dublin is endemic in the cattle population in some areas of the Austrian province Tyrol, and each year single dairy farms have experienced clinical infections. To ascertain if Tyrolean red foxes ( Vulpes vulpes ) act as a reservoir for Salmonella spp., we tested hepatic tissue and intestinal content from foxes hunted in the years 2015-2016 by using microbiological methods. In addition, we included several fox fecal samples collected on a mountain pasture near chamois carcasses in the investigation. Of 434 foxes tested, nine animals (2.1%) were positive for Salmonella spp. Serotyping revealed five foxes positive with S. Dublin, demonstrating that this serovar exists in the Tyrolean fox population. The fecal samples collected in the area surrounding skeletonized chamois ( Rupicapra rupicapra ) also tested positive for S. Dublin. These chamois were probably victims of a waterborne outbreak caused by S. Dublin-shedding cattle. Our results indicate that the S. Dublin infections in red foxes were primarily acquired through ingestion of infected cattle material such as abortion tissues, but also by feeding on dead chamois. The findings underline the importance of interspecies transmission in this domestic/wildlife interface.

  10. Proceedings of the International Conference on Dublin Core and Metadata Applications, 2001 [and] Presentation Materials (9th, Tokyo, Japan, October 24-26, 2001).

    ERIC Educational Resources Information Center

    Oyama, Keizo, Ed.; Gotoda, Hironobu, Ed.

    The Dublin Core Metadata Initiative has helped to create a community of people united in the common purpose of promoting cross-disciplinary resource discovery. DC-2001, the International Conference on Dublin Core and Metadata Applications 2001, is the first annual Dublin Core meeting in Asia, recognizing the growth of activities in the Asian…

  11. Formation and migration energies of the vacancy in Si calculated using the HSE06 range-separated hybrid functional

    NASA Astrophysics Data System (ADS)

    Śpiewak, Piotr; Kurzydłowski, Krzysztof J.

    2013-11-01

    To overcome deficiencies of conventional density functional theory (DFT) utilizing the standard approximation for the exchange-correlation, the revised Heyd-Scuseria-Ernzerhof screened hybrid functional (HSE06) has been used for calculating the formation and migration energies of the vacancy in Si. It is demonstrated that the hybrid approach gives a much more accurate electronic description of the bulk and the vacancy. The correct description of the band gap and the donor transition levels obtained with the HSE06 functional builds confidence in predictions of the vacancy acceptor states. The calculated migration energies of the vacancy with different charge states agree well with low-temperature annealing measurements and, together with formation energies, provide an excellent estimate of the activation energy of vacancy-mediated self-diffusion in silicon.

  12. An integrated experiment for identification of best decision styles and teamworks with respect to HSE and ergonomics program: The case of a large oil refinery.

    PubMed

    Azadeh, A; Mokhtari, Z; Sharahi, Z Jiryaei; Zarrin, M

    2015-12-01

    Decision making failure is a predominant human error in emergency situations. To demonstrate the subject model, operators of an oil refinery were asked to answer a health, safety and environment HSE-decision styles (DS) questionnaire. In order to achieve this purpose, qualitative indicators in HSE and ergonomics domain have been collected. Decision styles, related to the questions, have been selected based on Driver taxonomy of human decision making approach. Teamwork efficiency has been assessed based on different decision style combinations. The efficiency has been ranked based on HSE performance. Results revealed that efficient decision styles resulted from data envelopment analysis (DEA) optimization model is consistent with the plant's dominant styles. Therefore, improvement in system performance could be achieved using the best operator for critical posts or in team arrangements. This is the first study that identifies the best decision styles with respect to HSE and ergonomics factors. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. Crystal Field Effects and Siderophile Element Partitioning: Implications for Mars HSE Geochemistry

    NASA Technical Reports Server (NTRS)

    Jones, John H.; Malavergne, V.; Neal, C. R.

    2007-01-01

    Analyses of martian (SNC) meteorites indicate that Pt abundances do not vary much compared to other highly siderophile elements (HSE). Therefore, Jones et al. [1] inferred that D(Pt) during basalt petrogenesis was of order unity. This inference was at odds with previously published experiments that gave a D(sub ol/liq) for Pt of approx. 0.01 [2]. Because olivine is likely to be an important constituent of any reasonable martian mantle, the implication of these findings is that minor minerals must have D(Pt) much greater than 1, which seemed improbable. However, not only did the SNC evidence point to a D(sub ol/liq) approx. equal to 1, but so did plots of D(sub ol/liq) vs. ionic radius (Onuma diagram). The ionic radius of Pt(2+) suggested that D(sub ol/liq) for Pt was of order unity, in agreement with the inferences from SNC meteorites. New experiments have failed to detect measurable Pt in olivine, even at high oxygen fugacities [3]. Therefore, some other parameter, other than ionic charge and radius, must hold sway during olivine liquid partitioning of Pt.

  14. Spontaneous abortion in the British semiconductor industry: An HSE investigation. Health and Safety Executive.

    PubMed

    Elliott, R C; Jones, J R; McElvenny, D M; Pennington, M J; Northage, C; Clegg, T A; Clarke, S D; Hodgson, J T; Osman, J

    1999-11-01

    The UK Health and Safety Executive (HSE) conducted a study to examine the risk of spontaneous abortion (SAB) in British female semiconductor industry workers, following reports from the USA which suggested an association between risk of SAB and work in fabrication rooms and/or exposure to ethylene glycol ethers. A nested case-control study based on 2,207 women who had worked at eight manufacturing sites during a 5-year retrospective time frame was established; 36 cases were matched with 80 controls. The overall SAB rate in the industry was 10.0%. (65 SABs/651 pregnancies) The crude odds ratio (OR) for fabrication work was 0.65 (95% CI 0.30-1.40). This was essentially unchanged after adjustment for a range of potential confounding factors in the first 3 months of pregnancy and was reduced to 0.58 (95% CI 0.26-1.30) after adjustment for smoking in the previous 12 months. There were no statistically significantly elevated ORs for any work group or any specific chemical or physical exposure in the industry. There is no evidence of an increased risk of SAB in the British semiconductor industry. Am. J. Ind. Med. 36:557-572, 1999. Published 1999 Wiley-Liss, Inc.

  15. "A Victim of Its Own Success"? The Diploma in Addiction Studies at Trinity College Dublin

    ERIC Educational Resources Information Center

    Woods, Marguerite; Butler, Shane

    2011-01-01

    This article reviews and reflects on the Diploma in Addiction Studies: a 1-year, full-time programme taught at the School of Social Work and Social Policy in Trinity College Dublin since the academic year 1983/1984, which has recently had its external funding withdrawn. The programme was aimed at multidisciplinary classes, including students from…

  16. 75 FR 76953 - Foreign-Trade Zone 238-Dublin, VA Site Renumbering Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Foreign-Trade Zone 238--Dublin, VA Site Renumbering Notice Foreign-Trade Zone 238 was approved by the Foreign-Trade Zones Board on August 5, 1999 (Board Order 1047). FTZ 238...

  17. An American in Dublin: Visit to an Irish Primary School Demonstrates Learning Forward's International Impact

    ERIC Educational Resources Information Center

    Armstrong, Anthony

    2013-01-01

    A visit to a primary school in Dublin, Ireland, shows that, although the structure of the Irish school system is much different than in the U.S., the professional learning needs and challenges are very much the same. In this article, Anthony Armstrong, publications editor at Learning Forward, writes about his meeting with Maria Spring, principal…

  18. "A Victim of Its Own Success"? The Diploma in Addiction Studies at Trinity College Dublin

    ERIC Educational Resources Information Center

    Woods, Marguerite; Butler, Shane

    2011-01-01

    This article reviews and reflects on the Diploma in Addiction Studies: a 1-year, full-time programme taught at the School of Social Work and Social Policy in Trinity College Dublin since the academic year 1983/1984, which has recently had its external funding withdrawn. The programme was aimed at multidisciplinary classes, including students from…

  19. Dublin Institute of Technology's Programme for Students Learning with Communities: A Critical Account of Practice

    ERIC Educational Resources Information Center

    Gamble, Elena; Bates, Catherine

    2011-01-01

    Purpose: This paper aims to focus on the process of critically evaluating Dublin Institute of Technology's Programme for Students Learning With Communities after its first year of operation. The programme supports and promotes community-based learning/service-learning across DIT. Design/methodology/approach: The paper is presented in the form of a…

  20. "The Problem of Trinity College Dublin": A Historical Perspective on Rationalisation in Higher Education in Ireland

    ERIC Educational Resources Information Center

    Walsh, John

    2014-01-01

    This paper offers a historical perspective on government policies for the rationalisation of higher education (HE) in Ireland through a critical re-appraisal of the initiative for "merger" of Trinity College and University College Dublin. The initiative launched by Donogh O'Malley in 1967 was the first significant attempt by an Irish…

  1. Solving Long-Term Unemployment in Dublin: The Lessons from Policy Innovation. Policy Paper No. 2.

    ERIC Educational Resources Information Center

    Fitzgerald, Eithne; Ingolsby, Brid; Daly, Fiona

    This report identifies what policies can be effective in eliminating hard-core unemployment in Dublin and preventing its re-emergence in a new generation. An executive summary precedes the main body of the report. Chapter 1 describes the background of economic boom against which the persistence of long-term unemployment appears paradoxical;…

  2. "The Problem of Trinity College Dublin": A Historical Perspective on Rationalisation in Higher Education in Ireland

    ERIC Educational Resources Information Center

    Walsh, John

    2014-01-01

    This paper offers a historical perspective on government policies for the rationalisation of higher education (HE) in Ireland through a critical re-appraisal of the initiative for "merger" of Trinity College and University College Dublin. The initiative launched by Donogh O'Malley in 1967 was the first significant attempt by an Irish…

  3. Sir Patrick Dun and the Complete School of Physic in eighteenth-century Dublin.

    PubMed

    Mullaney, S

    2015-03-01

    2013 is the tercentenary of the death of Sir Patrick Dun. When Dun died in 1713, he left the proceeds of his estate to enhance medical education in Dublin by funding chairs in medicine. He showed remarkable innovation, but it took 95 years, five Acts of Parliament, two House of Commons enquiries and a House of Lords enquiry before Dun's wishes were brought to fruition and systematic clinical education was available for Dublin medical students. The passage of the final School of Physic Act in 1800 insured that a hospital would open in his name and regular clinical education was provided. The physician, Richard Steevens, who died 3 years earlier in 1710, left the proceeds of his estate to found a hospital, which opened, in his name, in 1733. The contemporary primary sources have been analysed and material from relevant secondary sources has been included where appropriate. Dublin was the beneficiary of these bequests and if circumstances had been more favourable, and the proceeds had been used more efficiently at the start of the eighteenth-century, Dublin could well have rivalled Edinburgh as the seat of medical education in the eighteenth century. In the early nineteenth century, it would fulfil that role and equal Edinburgh as one of the primary centres of medical education in Europe.

  4. First Report of Liver Abscess Caused by Salmonella enterica Serovar Dublin

    PubMed Central

    Qu, Fen; Fan, Zhenping; Cui, Enbo; Zhang, Wenjin; Bao, Chunmei; Chen, Suming

    2013-01-01

    This is the first reported case of liver abscess attributable to Salmonella serovar Dublin infection and also the fourth case of Salmonella liver abscess complicated with hepatocellular carcinoma reported since 1990. Drainage combined with intravenous antibiotics resulted in improvement, but recovery regressed again. Subsequent hepatic left lobectomy led to full recovery. PMID:23784127

  5. Giant hydronephrosis and secondary pyelonephritis induced by Salmonella dublin in a Holstein calf

    PubMed Central

    Taghipur Bazargani, T; Khodakaram-Tafti, A; Ashrafi, I; Abbassi, A. M.

    2015-01-01

    Hydronephrosis occurs as a congenital or an acquired condition following obstruction of the urinary tract. In this study, a four month old male Holstein calf with emaciation, growth retardation and a poor dry scruffy hair coat was examined because of remarkable distention of right abdomen. At necropsy, right kidney was hydronephrotic as a very big fluid-filled round pelvis with the presence of multilocular cysts bulged from the cortical surface. With sectioning, more than 10 L of bloody fluid poured out from this sac. Microscopic examination showed severe atrophy of cortical tissue and fibrosis of the medulla. Also, the dilated pelvis was composed of fibrinous exudate and necrosis of epithelium associated with multifocal aggregations of neutrophils and bacterial microcolonies. In a culture and serotyping of isolated bacteria, Salmonella dublin was determined. In conclusion, S. dublin induced pyelonephritis secondary to congenital giant hydronephrosis is the first report in cattle in the world. PMID:27175163

  6. On phase transitions in NH_{4HSeO4} and ND{4}DSeO{4}

    NASA Astrophysics Data System (ADS)

    Dvořák, V.; Quilichini, M.; Le Calvé, N.; Pasquier, B.; Heger, G.; Schweiss, P.

    1991-10-01

    We propose a hypothetical prototype phase (space group Imm) from which all observed phases in NH{4}HSeO{4} and ND{4}DSeO{4} can be deduced by introducing order parameters of definite symmetries. Following this hypothesis the symmetry of the superionic phase should be P2/n in disagreement with recent experimental results. Free energies of Landau type are derived by means of which particular phase transitions could be described. The large dielectric anomaly near 252 K in NH{4}HSeO{4} is discussed in some detail. The first order phase transition in ND{4}DSeO{4} from the room temperature phase P2{1}2121 into commensurate lock-in phase (with the wave-vector k {z}(0,0, frac{π}{c})) has been investigated by neutron elastic scattering and the symmetry of the latter has been found to be P112{1} in agreement with our theoretical prediction. Nous proposons une phase prototype hypothétique (de groupe d'espace Immm) à partir de laquelle on peut déduire toutes les phases observées dans NH{4}HSeO{4} et ND{4}DSeO{4} par l'introduction de paramètres d'ordre ayant une symétrie définie. D'après cette hypothèse le groupe d'espace de la phase superionique doit être P2/n ce qui est en désaccord avec des résultats expérimentaux récents. Pour chaque transition de phase on écrit l'énergie libre de type Landau à partir de laquelle elle peut être décrite. La grande anomalie diélectrique au voisinage de 252 K dans le composé NH{4}HSeO{4} est discutée de façon détaillée. Dans le composé ND{4}DSeO{4}, nous avons étudié par diffusion élastique de neutrons la transition de phase du premier ordre qui transforme le cristal de la structure P2{1}2121 dans la phase commensurable d'accrochage (de vecteur d'onde k {z}(0,0, frac{π}{c})). Nous avons montré que la symétrie de cette phase est P112{1}, ce qui en accord avec nos prévisions théoriques.

  7. Will house prices rise in 2007? A comparative assessment of house prices in London and Dublin

    NASA Astrophysics Data System (ADS)

    Richmond, Peter

    House prices are of concern to many people and in recent years they seem to have gone through one of their periodic up turns. In a previous paper [4] we offered empirical evidence suggesting that prices in both the UK and Dublin had peaked and suggested prices computed relative to inflation would fall over the next few years. Here we assess progress in the light of further data now available.

  8. Comparison of the environmental survival characteristics of Salmonella Dublin and Salmonella Typhimurium.

    PubMed

    Kirchner, Miranda J; Liebana, Ernesto; McLaren, Ian; Clifton-Hadley, Felicity A; Wales, Andrew D; Davies, Robert H

    2012-10-12

    To examine possible correlations in bovine Salmonella isolates between environmental survival and serovar-associated epidemiological patterns, bovine field isolates of Salmonella serovars Typhimurium and Dublin (two each) were inoculated into bovine faeces slurry and tested monthly by culture for survival during a six-month period of storage at a variable ambient temperature in a disused animal transporter. Low moisture conditions, where the slurry was dried onto wooden dowels, increased detectable survival of a low-level inoculum by up to five months, compared with wet slurry. A more modest increase of survival time was seen with storage of wet slurry under refrigeration at 4°C. Under both dry and wet conditions, the concentration of culturable Salmonella Typhimurium declined at a slower rate than did that of Salmonella Dublin. Salmonella that was naturally contaminating bovine faeces from farms with Salmonella Typhimurium did not show superior survival times compared with Salmonella Typhimurium that had been artificially inoculated into samples. The differing survival characteristics of the two serovars that was observed in environmental faeces may complement their different modes of infection in cattle. Salmonella Dublin, being a bovine host-adapted strain that establishes chronic infection in some animals, may have less need to survive for a prolonged period outside of its host than does Salmonella Typhimurium.

  9. The Dublin Dashboard: Design and Development of a Real-Time Analytical Urban Dashboard

    NASA Astrophysics Data System (ADS)

    McArdle, G.; Kitchin, R.

    2016-09-01

    As many cities increase in size across multiple dimensions such as population, economic output and physical size, new methods for understanding and managing cities are required. Data produced by and about urban environments offer insight into what is happening in cities. Real-time data from sensors within the city record current transport and environmental conditions such as noise levels, water levels, journey times and public transport delays. Similarly administrative data such as demographics, employment statistics, property prices and crime rates all provide insight into how a city is evolving. Traditionally, these data were maintained separately and managed by individual city departments. Advances in technology and a move to open-government have placed many of these data in the public domain. Urban dashboards have emerged as a technique to visualise these data in an accessible way. This paper describes the implementation of one such dashboard, the Dublin Dashboard, an interactive website which collects, analyses and visualises data from a variety of sources about Dublin in Ireland through a series of interactive maps, graphs and applications. This paper describes the approach, the data and the technology used to develop the Dublin Dashboard and acts as a guideline for developing urban dashboards in other cities.

  10. An experimental study on the geochemical behavior of highly siderophile elements (HSE) and metalloids (As, Se, Sb, Te, Bi) in a mss-iss-pyrite system at 650 °C: A possible magmatic origin for Co-HSE-bearing pyrite and the role of metalloid-rich phases in the fractionation of HSE

    NASA Astrophysics Data System (ADS)

    Cafagna, Fabio; Jugo, Pedro J.

    2016-04-01

    Pyrite, the most abundant sulfide in the Earth's crust, is an accessory mineral in several magmatic sulfide deposits. Although most pyrite is hydrothermal, previous experimental studies have shown that pyrite can also have a primary magmatic origin, by exsolving from monosulfide solid solution (mss) during cooling of a sulfide melt, if sulfur fugacity is sufficiently high. Pyrite from some localities has significant amounts of Co, and complex zonation in some low-melting-point chalcophile elements (LMCE), such as As, Se, Sb, Te, Bi (henceforth referred to as metalloids) and some platinum-group elements (PGE: Ru, Rh, Pd, Os, Ir, Pt). However, the origin of such pyrite and the causes of zonation are not clear. Because the distribution of some of these elements is heterogeneous and seems to be developed in concentric zones, the zonation has been interpreted to represent growth stages, some of them secondary and caused partly by hydrothermal fluids. Better constraints on the origin of Co-PGE-bearing pyrite could help unravel the geochemical processes affecting the sulfide assemblages in which it is found; thus, an experimental study was undertaken to characterize pyrite formation in magmatic sulfide environments and its relationship with metalloids and highly siderophile elements (HSE: PGE, Re, Au). Natural pyrrhotite, chalcopyrite, pentlandite and elemental S were mixed and doped with approximately 50 ppm of each HSE. A mixture of metalloids was added at 0.2 wt.% or 3 wt.% to aliquots of sulfide mixtures. Starting materials were sealed in evacuated silica tubes and fused at 1200 °C. The temperature was subsequently reduced to 750 °C (at 60 °C/h), then to 650 °C (at 0.5 °C/h) to produce relatively large euhedral pyrite crystals, then quenched. The experiments were analyzed using reflected light, SEM, EPMA and LA-ICP-MS. Experimental products contained euhedral pyrite, mss, intermediate solid solution (iss) and metalloid-rich phases, interpreted as quench product

  11. Genomic comparison of the closely-related Salmonella enterica serovars enteritidis, dublin and gallinarum

    SciTech Connect

    Matthews, T. David; Schmieder, Robert; Silva, Genivaldo G. Z.; Busch, Julia; Cassman, Noriko; Dutilh, Bas E.; Green, Dawn; Matlock, Brian; Heffernan, Brian; Olsen, Gary J.; Hanna, Leigh Farris; Schifferli, Dieter M.; Maloy, Stanley; Dinsdale, Elizabeth A.; Edwards, Robert A.; Cloeckaert, Axel

    2015-06-03

    The Salmonella enterica serovars Enteritidis, Dublin, and Gallinarum are closely related but differ in virulence and host range. To identify the genetic elements responsible for these differences and to better understand how these serovars are evolving, we sequenced the genomes of Enteritidis strain LK5 and Dublin strain SARB12 and compared these genomes to the publicly available Enteritidis P125109, Dublin CT 02021853 and Dublin SD3246 genome sequences. We also compared the publicly available Gallinarum genome sequences from biotype Gallinarum 287/91 and Pullorum RKS5078. Using bioinformatic approaches, we identified single nucleotide polymorphisms, insertions, deletions, and differences in prophage and pseudogene content between strains belonging to the same serovar. Through our analysis we also identified several prophage cargo genes and pseudogenes that affect virulence and may contribute to a host-specific, systemic lifestyle. These results strongly argue that the Enteritidis, Dublin and Gallinarum serovars of Salmonella enterica evolve by acquiring new genes through horizontal gene transfer, followed by the formation of pseudogenes. As a result, the loss of genes necessary for a gastrointestinal lifestyle ultimately leads to a systemic lifestyle and niche exclusion in the host-specific serovars.

  12. Histopathology case definition of naturally acquired Salmonella enterica serovar Dublin infection in young Holstein cattle in the northeastern United States.

    PubMed

    Pecoraro, Heidi L; Thompson, Belinda; Duhamel, Gerald E

    2017-06-01

    Salmonella enterica subsp. enterica serovar Dublin ( Salmonella Dublin) is a host-adapted bacterium that causes high morbidity and mortality in dairy cattle worldwide. A retrospective search of archives at the New York Animal Health Diagnostic Center revealed 57 culture-confirmed Salmonella Dublin cases from New York and Pennsylvania in which detailed histology of multiple tissues was available. Tissues routinely submitted by referring veterinarians for histologic evaluation included sections of heart, lungs, liver, spleen, and lymph nodes. Of the 57 S almonella Dublin-positive cases, all were Holstein breed, 53 were female (93%), and 49 (86%) were <6 mo of age. Specifically, in calves <6 mo of age, >90% (45 of 49) of lungs, 90% (28 of 31) of livers, 50% (11 of 22) of spleens, and 62% (18 of 29) of lymph nodes examined had moderate-to-severe inflammation with or without necrosis. Inconstant lesions were seen in 48% (10 of 21) of hearts examined, and consisted of variable inflammatory infiltrates and rare areas of necrosis. We propose a histopathology case definition of Salmonella Dublin in <6-mo-old Holstein cattle that includes a combination of pulmonary alveolar capillary neutrophilia with or without hepatocellular necrosis and paratyphoid granulomas, splenitis, and lymphadenitis. These findings will assist in the development of improved protocols for the diagnosis of infectious diseases of dairy cattle.

  13. New insights from old spherules: Os-W isotope and HSE evidence for Paleoarchean meteorite bombardment of the Earth

    NASA Astrophysics Data System (ADS)

    Schulz, T.; Luguet, A. A.; Koeberl, C.

    2014-12-01

    Introduction: Although still debated, spherule beds in the Barberton Mountain Land (~3.4 Ga) are suspected to represent remnants of impact-generated and ballistically emplaced silicate melt droplets [e.g. 1]. Such deposits provide the only window into the late stages of the heavy meteorite bombardment on Earth as their source craters have long since been obliterated. In order to identify a possible meteoritic component and, if successful, to discuss potential projectile materials, we are performing a detailed Os-W isotope as well as HSE abundance study on spherule layers from the recently drilled ICDP BARB5 core (grid location 25°30`50.76``S, 31°33`10.08``E). Samples and Methods: Samples were taken from a spherule-containing meta-sedimentary core section discovered between 510 and 512 m depth. About 100 mg of homogenized sample powders were spiked with a mixed 190Os, 185Re, 191Ir and 194Pt tracer and treated in a high pressure asher using inverse aqua regia, followed by conventional extraction schemes for Os and the other HSEs [4]. Chemical and Os isotope measurements (via N-TIMS) were performed in Vienna, whereas HSE measurements were undertaken via ICP MS in Bonn. Results and Discussion: Our preliminary Os isotope data reveal a trend between samples exhibiting high spherule to matrix ratios (187Os/188Os ~0.106 and Os ~0.4 ppm) and samples with lower ones (187Os/188Os up to ~0.304 and Os ~0.008 ppm). Notably, the most unradiogenic samples exhibit carbonaceous-chondrite-like initial 187Os/188Os and HSE ratios, whereas all other samples are clear non-chondritic. These findings support an extraterrestrial contribution in the spherules and can be interpreted compared to conclusions drawn from a Cr isotope study performed on similar samples [3], possibly representing a different impact event and favouring a chondritic projectile. However, further considerations based on precise Os/W ratio determinations and high-precision 182W isotope data, will be presented at the

  14. Testing the Validity of the Implicit Relational Assessment Procedure and the Implicit Association Test: Measuring Attitudes toward Dublin and Country Life in Ireland

    ERIC Educational Resources Information Center

    Barnes-Holmes, Dermot; Waldron, Deirdre; Barnes-Holmes, Yvonne; Stewart, Ian

    2009-01-01

    The current study aimed to test the validity of the Implicit Relational Assessment Procedure (IRAP), as compared to the Implicit Association Test (IAT), by assessing the attitudes of Dublin dwellers and rural dwellers toward Dublin and country life. Discrimination between the two groups for the IAT was marginally significant. The IRAP…

  15. Job stress: an in-depth investigation based on the HSE questionnaire and a multistep approach in order to identify the most appropriate corrective actions.

    PubMed

    De Sio, S; Cedrone, F; Greco, E; Di Traglia, M; Sanità, D; Mandolesi, D; Stansfeld, S A

    2016-01-01

    Psychosocial hazards and work-related stress have reached epidemic proportions in Europe. The Italia law introduced in 2008 the obligation for Italian companies to assess work related stress risk in order to protect their workers' safety and health. The purpose of our study was to propose an accurate measurement tool, using the HSE indicator tool, for more appropriate and significant work-related stress' prevention measures. The study was conducted on 204 visual display unit (VDU) operators: 106 male and 98 female. All subjects were administered the HSE questionnaire. The sample was studied through a 4 step process, using HSE analysis tool and a statistical analysis, based on the odds ratio calculation. The assessment model used demonstrated the presence of work related stress in VDU operators and additional "critical" aspects which had failed to emerge by the classical use of HSE analysis tool. The approach we propose allows to obtain a complete picture of the perception of work-related stress and can point out the most appropriate corrective actions.

  16. Targeted intervention strategies to optimise diversion of BMW in the Dublin, Ireland region.

    PubMed

    Purcell, M; Magette, W L

    2011-01-01

    Urgent transformation is required in Ireland to divert biodegradable municipal waste (BMW) from landfill and prevent increases in overall waste generation. When BMW is optimally managed, it becomes a resource with value instead of an unwanted by-product requiring disposal. An analysis of survey responses from commercial and residential sectors for the Dublin region in previous research by the authors proved that attitudes towards and behaviour regarding municipal solid waste is spatially variable. This finding indicates that targeted intervention strategies designed for specific geographic areas should lead to improved diversion rates of BMW from landfill, a requirement of the Landfill Directive 1999/31/EC. In the research described in this paper, survey responses and GIS model predictions from previous research were the basis for goal setting, after which logic modelling and behavioural research were employed to develop site-specific waste management intervention strategies. The main strategies devised include (a) roll out of the Brown Bin (Organics) Collection and Community Workshops in Dún Laoghaire Rathdown, (b) initiation of a Community Composting Project in Dublin City (c) implementation of a Waste Promotion and Motivation Scheme in South Dublin (d) development and distribution of a Waste Booklet to promote waste reduction activities in Fingal (e) region wide distribution of a Waste Booklet to the commercial sector and (f) Greening Irish Pubs Initiative. Each of these strategies was devised after interviews with both the residential and commercial sectors to help make optimal waste management the norm for both sectors. Strategy (b), (e) and (f) are detailed in this paper. By integrating a human element into accepted waste management approaches, these strategies will make optimal waste behaviour easier to achieve. Ultimately this will help divert waste from landfill and improve waste management practice as a whole for the region. This method of devising

  17. Development of risk filter and risk assessment worksheets for HSE guidance--'Upper Limb Disorders in the Workplace' 2002.

    PubMed

    Graves, Rod J; Way, Kïrsten; Riley, David; Lawton, Clare; Morris, Len

    2004-09-01

    Upper limb disorders (ULDs) in the workplace represent a significant cause of ill health in Great Britain. As part of the Health and Safety Commission's strategy for the prevention of musculoskeletal disorders (MSDs), the well known guidance document on ULDs--"Work-related Upper Limb Disorders: a Guide to Prevention" (HSG60), (HMSO, London.), has been extensively revised. This revision (Upper limb disorders in the workplace. HSG60 (rev), HSE Books, Sudbury.) includes the development of new risk assessment tools that can be used by employers to identify ULD risk factors in work activities and more importantly to take action to reduce or eliminate ULD risks. The risk assessment tools form part of a seven stage management approach that underpins the new guidance. This paper outlines the development of the risk assessment tools contained in the revised guidance.

  18. Screening and ranking framework (SRF) for geologic CO2 storagesite selection on the basis of HSE risk

    SciTech Connect

    Oldenburg, Curtis M.

    2006-11-27

    A screening and ranking framework (SRF) has been developedto evaluate potential geologic carbon dioxide (CO2) storage sites on thebasis of health, safety, and environmental (HSE) risk arising from CO2leakage. The approach is based on the assumption that CO2 leakage risk isdependent on three basic characteristics of a geologic CO2 storage site:(1) the potential for primary containment by the target formation; (2)the potential for secondary containment if the primary formation leaks;and (3) the potential for attenuation and dispersion of leaking CO2 ifthe primary formation leaks and secondary containment fails. Theframework is implemented in a spreadsheet in which users enter numericalscores representing expert opinions or published information along withestimates of uncertainty. Applications to three sites in Californiademonstrate the approach. Refinements and extensions are possible throughthe use of more detailed data or model results in place of propertyproxies.

  19. The Dublin Principles of cooperation among the beverage alcohol industry, governments, scientific researchers, and the public health community.

    PubMed

    Hannum, H

    1997-01-01

    A 3-day Meeting held in Dublin, Ireland on 26-28 May 1997 was organized by the National College of Industrial Relations of Ireland and the US-based International Center for Alcohol Policies. During this Meeting, the 24 participants representing the beverage alcohol industry, governmental organizations and the scientific and public health communities discussed cooperation among all those concerned with alcohol consumption and its effects. These discussions led to the formulation of the 'Dublin Principles of Cooperation'. This special article describes these Principles and comments on them.

  20. C2-C6 background hydrocarbon concentrations monitored at a roof top and green park site, in Dublin City centre.

    PubMed

    O'Donoghue, R T; Broderick, B M

    2007-09-01

    A 5 week monitoring campaign was carried out in Dublin City centre, to establish which site gave a more accurate background city centre estimation: a roof-top or green field site. This background represented a conservative estimate of HC exposure in Dublin City centre, useful for quantifying health effects related to this form of pollution and also for establishing a local background relative to the four surrounding main roads when the wind direction is travelling towards each road with the background receptor upwind. Over the entire monitoring campaign, the lowest concentrations and relative standard deviations were observed at the green field site, regardless of time of day or meteorological effects.

  1. Dietary proteins extend the survival of Salmonella Dublin in a gastric acid environment.

    PubMed

    Birk, Tina; Kristensen, Kim; Harboe, Anne; Hansen, Tina Beck; Ingmer, Hanne; De Jonge, Rob; Takumi, Katsuhisa; Aabo, Søren

    2012-02-01

    The pH of the human stomach is dynamic and changes over time, depending on the composition of the food ingested and a number of host-related factors such as age. To evaluate the number of bacteria surviving the gastric acid barrier, we have developed a simple gastric acid model, in which we mimicked the dynamic pH changes in the human stomach. In the present study, model gastric fluid was set up to imitate pH dynamics in the stomachs of young and elderly people after ingestion of a standard meal. To model a serious foodborne pathogen, we followed the survival of Salmonella enterica serotype Dublin, and found that the addition of proteins such as pepsin, ovalbumin, and blended turkey meat to the simple gastric acid model significantly delayed pathogen inactivation compared with the control, for which no proteins were added. In contrast, no delay in inactivation was observed in the presence of bovine serum albumin, indicating that protection could be protein specific. The simple gastric acid model was validated against a more laborious and complex fermenter model, and similar survival of Salmonella Dublin was observed in both models. Our gastric acid model allowed us to evaluate the influence of food components on survival of pathogens under gastric conditions, and the model could contribute to a broader understanding of the impact of specific food components on the inactivation of pathogens during gastric passage.

  2. Outbreak of Salmonella Dublin-associated abortion in Danish fur farms

    PubMed Central

    Dietz, Hans Henrik; Chriél, Mariann; Andersen, Thomas Holmen; Jørgensen, Jens Christian; Torpdahl, Mia; Pedersen, Hans; Pedersen, Karl

    2006-01-01

    Outbreaks of Salmonella Dublin infections were recorded in 25 Danish mink and fox farms. All farms suffered extensive disease problems; clinical and pathological observations included abortion, stillbirths, necrotizing endometritis, and increased mortality. By genotyping with pulsed-field gel electrophoresis and amplified fragment length polymorphism, all isolates of S. Dublin had indistinguishable patterns. The outbreaks took place during April and May, around the time of whelping. During this period, mink are particularly susceptible to Salmonella infections. All affected farms were served by the same feed factory and it was concluded that a batch of contaminated feed was responsible for the outbreaks, although repeated culture of feed samples collected during the same period were negative. No other likely source could be identified. The results emphasize the importance of strict hygiene measures at feed factories and the proper use of ingredients of known Salmonella status, in particular during the whelping season. Infected mink farms did not have a higher risk of outbreak of salmonellosis in the year following the outbreak. PMID:17217090

  3. Outbreak of Salmonella Dublin-associated abortion in Danish fur farms.

    PubMed

    Dietz, Hans Henrik; Chriél, Mariann; Andersen, Thomas Holmen; Jørgensen, Jens Christian; Torpdahl, Mia; Pedersen, Hans; Pedersen, Karl

    2006-12-01

    Outbreaks of Salmonella Dublin infections were recorded in 25 Danish mink and fox farms. All farms suffered extensive disease problems; clinical and pathological observations included abortion, stillbirths, necrotizing endometritis, and increased mortality. By genotyping with pulsed-field gel electrophoresis and amplified fragment length polymorphism, all isolates of S. Dublin had indistinguishable patterns. The outbreaks took place during April and May, around the time of whelping. During this period, mink are particularly susceptible to Salmonella infections. All affected farms were served by the same feed factory and it was concluded that a batch of contaminated feed was responsible for the outbreaks, although repeated culture of feed samples collected during the same period were negative. No other likely source could be identified. The results emphasize the importance of strict hygiene measures at feed factories and the proper use of ingredients of known Salmonella status, in particular during the whelping season. Infected mink farms did not have a higher risk of outbreak of salmonellosis in the year following the outbreak.

  4. Beta-glucan plus ascorbic acid in neonatal calves modulates immune functions with and without Salmonella enterica serovar Dublin

    USDA-ARS?s Scientific Manuscript database

    Calves often succumb to Salmonella enterica, Dublin after maternal antibody protection has abated. Enhancement of innate immunity or earlier maturation of adaptive immunity to support vaccinations with dietary immune modulators may be the best option for protection during this vulnerable period. I...

  5. 76 FR 22804 - Technical Amendment to List of CBP Preclearance Offices in Foreign Countries: Addition of Dublin...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-25

    ... Offices in Foreign Countries: Addition of Dublin, Ireland AGENCY: U.S. Customs and Border Protection, DHS. ACTION: Final rule; technical amendment. SUMMARY: This document amends U.S. Customs and Border Protection... further CBP processing. Preclearance facilities primarily serve to facilitate low risk travelers, relieve...

  6. The Road To Meta: The Implementation of Dublin Core Metadata in the State Library of Queensland Web site.

    ERIC Educational Resources Information Center

    Thornely, Jenny

    1998-01-01

    The goal of the State Library of Queensland's (Australia) Metadata Project is the deployment of metadata using the Dublin Core Metadata Element Set in State Library Web pages. This is expected to improve resource discovery by Internet users, through providing index information (metadata) in State Library Web pages which is then available to search…

  7. Towards a For-Profit University in Dublin: Another Brick in the Wall of Neo-Liberalism?

    ERIC Educational Resources Information Center

    Limond, David

    2010-01-01

    This article concerns the provision of for-profit higher education in the Republic of Ireland (RoI), particularly in Dublin. It briefly sketches the general development of university/college provision in the RoI and, more importantly, it describes certain aspects of the current state of play and makes a tentative prediction for the future--namely,…

  8. Developing Online Tutorials to Improve Information Literacy Skills for Second-Year Nursing Students of University College Dublin

    ERIC Educational Resources Information Center

    Walters, Kirsteen; Bolich, Cecilia; Duffy, Daniel; Quinn, Ciarán; Walsh, Kathryn; Connolly, Sarah

    2015-01-01

    This article explores the process of developing online tutorials for a specified student group, in this case Second-Year Nursing students in University College Dublin. The product was commissioned by the Health Sciences Library and the UCD School of Nursing, Midwifery, and Health Systems. It was developed as a "Capstone Project" for part…

  9. Developing Online Tutorials to Improve Information Literacy Skills for Second-Year Nursing Students of University College Dublin

    ERIC Educational Resources Information Center

    Walters, Kirsteen; Bolich, Cecilia; Duffy, Daniel; Quinn, Ciarán; Walsh, Kathryn; Connolly, Sarah

    2015-01-01

    This article explores the process of developing online tutorials for a specified student group, in this case Second-Year Nursing students in University College Dublin. The product was commissioned by the Health Sciences Library and the UCD School of Nursing, Midwifery, and Health Systems. It was developed as a "Capstone Project" for part…

  10. Gross margin losses due to Salmonella Dublin infection in Danish dairy cattle herds estimated by simulation modelling.

    PubMed

    Nielsen, T D; Kudahl, A B; Østergaard, S; Nielsen, L R

    2013-08-01

    Salmonella Dublin affects production and animal health in cattle herds. The objective of this study was to quantify the gross margin (GM) losses following introduction and spread of S. Dublin within dairy herds. The GM losses were estimated using an age-structured stochastic, mechanistic and dynamic simulation model. The model incorporated six age groups (neonatal, pre-weaned calves, weaned calves, growing heifers, breeding heifers and cows) and five infection stages (susceptible, acutely infected, carrier, super shedder and resistant). The effects of introducing one S. Dublin infectious heifer were estimated through 1000 simulation iterations for 12 scenarios. These 12 scenarios were combinations of three herd sizes (85, 200 and 400 cows) and four management levels (very good, good, poor and very poor). Input parameters for effects of S. Dublin on production and animal health were based on literature and calibrations to mimic real life observations. Mean annual GMs per cow stall were compared between herds experiencing within-herd spread of S. Dublin and non-infected reference herds over a 10-year period. The estimated GM losses were largest in the first year after infection, and increased with poorer management and herd size, e.g. average annual GM losses were estimated to 49 euros per stall for the first year after infection, and to 8 euros per stall annually averaged over the 10 years after herd infection for a 200 cow stall herd with very good management. In contrast, a 200 cow stall herd with very poor management lost on average 326 euros per stall during the first year, and 188 euros per stall annually averaged over the 10-year period following introduction of infection. The GM losses arose from both direct losses such as reduced milk yield, dead animals, treatment costs and abortions as well as indirect losses such as reduced income from sold heifers and calves, and lower milk yield of replacement animals. Through sensitivity analyses it was found that the

  11. Hydrogeology and water quality of the Dublin and Midville aquifer systems at Waynesboro, Burke County, Georgia, 2011

    USGS Publications Warehouse

    Gonthier, Gerard

    2013-01-01

    The hydrogeology and water quality of the Dublin and Midville aquifer systems were characterized in the City of Waynesboro area in Burke County, Georgia, based on geophysical and drillers’ logs, flowmeter surveys, a 24-houraquifer test, and the collection and chemical analysis of water samples in a newly constructed well. At the test site, the Dublin aquifer system consists of interlayered sands and clays between depths of 396 and 691 feet, and the Midville aquifer system consists of a sandy clay layer overlying a sand and gravel layer between depths of 728 and 936 feet. The new well was constructed with three screened intervals in the Dublin aquifer system and four screened intervals in the Midville aquifer system. Wellbore-flowmeter testing at a pumping rate of 1,000 gallons per minute indicated that 52.2 percent of the total flow was from the shallower Dublin aquifer system with the remaining 47.8 percent from the deeper Midville aquifer system. The lower part of the lower Midville aquifer (900 to 930 feet deep), contributed only 0.1 percent of the total flow. Hydraulic properties of the two aquifer systems were estimated using data from two wellbore-flowmeter surveys and a 24-hour aquifer test. Estimated values of transmissivity for the Dublin and Midville aquifer systems were 2,000 and 1,000 feet squared per day, respectively. The upper and lower Dublin aquifers have a combined thickness of about 150 feet and the horizontal hydraulic conductivity of the Dublin aquifer system averages 10 feet per day. The upper Midville aquifer, lower Midville confining unit, and lower Midville aquifer have a combined thickness of about 210 feet, and the horizontal hydraulic conductivity of the Midville aquifer system averages 6 feet per day. Storage coefficient of the Dublin aquifer system, computed using the Theis method on water-level data from one observation well, was estimated to be 0.0003. With a thickness of about 150 feet, the specific storage of the Dublin aquifer

  12. Cleaning validation 1: development and validation of a chromatographic method for the detection of traces of LpHse detergent.

    PubMed

    Zayas, José; Colón, Héctor; Garced, Omar; Ramos, Leyda M

    2006-05-03

    A high performance liquid chromatography (HPLC) method for the detection of traces of LpHse (4-tert-amylphenol and 2-phenylphenol) has been developed and validated. The method was shown to be linear in the range from 0.5 to 10.00 ppm in solution. The method was also shown to be accurate with a recovery of up to 95% by area response for amylphenol and up to 94% by area response for phenylphenol from metal surfaces (4''x4'' un-polished 304 stainless steel plates) by means of swab material. The reproducibility of the method was determined to be 1.61% by area response and 1.52% by height response for amylphenol and 5.40% by area response and 13.77% by height response for phenylphenol from solutions reported as the pooled relative standard deviation. The developed method was also shown to be rugged by comparisons of different preparations by different analysts. The limit of detection was established to be 0.076 ppm by peak area, 0.079 ppm by peak height for amylphenol and 0.34 ppm by peak area, 0.82 ppm by peak height for phenylphenol from solution, and 1.77 ppb by peak area, 1.23 ppm by peak height for amylphenol and 1.23 ppm by peak area, 1.44 ppm by peak height for phenylphenol from recovery from metal studies. The limit of quantitation was established to be 0.25 ppm by peak area, 0.26 ppm by peak height for amylphenol and 1.14 ppm by peak area, 2.73 ppm by peak height for phenylphenol from solution, and 3.89 ppm by peak area, 4.11 ppm by peak height for amylphenol and 4.11 ppm by peak area, 4.79 ppm by peak height for phenylphenol from recovery from metal plates studies. This method can be employed to determine the presence of LpHse residues in cleaned equipments where the detergent was used.

  13. Targeted intervention strategies to optimise diversion of BMW in the Dublin, Ireland region

    SciTech Connect

    Purcell, M.; Magette, W.L.

    2011-09-15

    Highlights: > Previous research indicates that targeted strategies designed for specific areas should lead to improved diversion. > Survey responses and GIS model predictions from previous research were the basis for goal setting. > Then logic modelling and behavioural research were employed to develop site-specific management intervention strategies. > Waste management initiatives can be tailored to specific needs of areas rather than one size fits all means currently used. - Abstract: Urgent transformation is required in Ireland to divert biodegradable municipal waste (BMW) from landfill and prevent increases in overall waste generation. When BMW is optimally managed, it becomes a resource with value instead of an unwanted by-product requiring disposal. An analysis of survey responses from commercial and residential sectors for the Dublin region in previous research by the authors proved that attitudes towards and behaviour regarding municipal solid waste is spatially variable. This finding indicates that targeted intervention strategies designed for specific geographic areas should lead to improved diversion rates of BMW from landfill, a requirement of the Landfill Directive 1999/31/EC. In the research described in this paper, survey responses and GIS model predictions from previous research were the basis for goal setting, after which logic modelling and behavioural research were employed to develop site-specific waste management intervention strategies. The main strategies devised include (a) roll out of the Brown Bin (Organics) Collection and Community Workshops in Dun Laoghaire Rathdown, (b) initiation of a Community Composting Project in Dublin City (c) implementation of a Waste Promotion and Motivation Scheme in South Dublin (d) development and distribution of a Waste Booklet to promote waste reduction activities in Fingal (e) region wide distribution of a Waste Booklet to the commercial sector and (f) Greening Irish Pubs Initiative. Each of these

  14. Shell shock in Ireland: The Richmond War Hospital, Dublin (1916-19).

    PubMed

    Kelly, Brendan D

    2015-03-01

    The history of mental disorders occasioned by World War I is a complex and important history, indelibly linked with social, political and cultural circumstances, and the history of the war itself. The Richmond War Hospital was a 32-bed establishment on the grounds of the large Richmond District Asylum in Dublin which, from 16 June 1916 until 23 December 1919, treated 362 soldiers with shell shock and other mental disorders, of whom more than half were considered to have recovered. Despite the limitations of the Richmond War Hospital, it was a generally forward-looking institution that pointed the way for future reform of Ireland's asylum system and, along with the other war hospitals, brought significant changes to the practice of psychiatry.

  15. Reduced exposure to air pollution on the boardwalk in Dublin, Ireland. Measurement and prediction.

    PubMed

    McNabola, A; Broderick, B M; Gill, L W

    2008-01-01

    This paper outlines an air pollution study carried out on Dublin city's recently completed boardwalk along the side of and overhanging the River Liffey. Air quality samples were taken along the length of the boardwalk to investigate whether pedestrians using the boardwalk would have a lower air pollution exposure than those using the adjoining footpath along the road. The results of the study show significant reductions in pedestrian exposure to both traffic derived particulates and hydrocarbons along the boardwalk as opposed to the footpath. Computational fluid dynamics was also used to model the outcome of these field measurements and shows the importance of the boundary wall between the footpath and boardwalk in reducing air pollution exposure for the pedestrian, the results of which are also presented herein.

  16. The letter from Dublin: climate change, colonialism, and the Royal Society in the seventeenth century.

    PubMed

    Vogel, Brant

    2011-01-01

    This article discusses an anonymous letter published in the Philosophical Transactions in 1676 that reports the theories of American colonists about the cause of their warming climate (cultivation and deforestation), and offers Ireland's colonial experience as a counterexample: Ireland was a colony with decreased cultivation, but the same perceived warming. That such an objection seemed necessary to the author shows that anthropogenic climate change could be a subject of debate and that the concept of climate was tied into theories of land use and to the colonial enterprise. Since he was liminal to both the Royal Society of London and the intellectual circles of Dublin, his skepticism, contextualized here, questions both the elite discourse and the discourse at the colonial periphery.

  17. EBM metadata based on Dublin Core better presenting validity of clinical trials.

    PubMed

    Xu, Wei; Okada, Mihoko

    2007-10-01

    To help clinicians find better evidence, a metadata schema for Evidence Based Medicine (EBM) is developed. Dublin Core metadata standard (DC) was adopted to help build a metadata schema. An experimental system was developed to test the validity of the metadata and full text papers of clinical therapy on stomach ulcer extracted using PubMed. An EBM metadata schema was developed. Citations were created from original papers using the metadata schema. Three clinicians evaluated papers by utilizing metadata and full texts respectively. Agreement of evaluation was analyzed, and the result on weighted kappa was 0.55 (95% CI, 0.42-0.67). It reveals that there is moderate agreement between evaluation of metadata citations and full texts. It is possible to use the metadata to select papers before reading the full texts. A further study should be made to prove the applicability of the metadata in the real world setting.

  18. [Assessing work-related stress: an Italian adaptation of the HSE Management Standards Work-Related Stress Indicator Tool].

    PubMed

    Marcatto, Francesco; D'Errico, Giuseppe; Di Blas, Lisa; Ferrante, Donatella

    2011-01-01

    The aim of this paper is to present a preliminary validation of an Italian adaptation of the HSE Management Standards Work-Related Stress Indicator Tool (IT), an instrument for assessing work-related stress at the organizational level, originally developed in Britain by the Health and Safety Executive. A scale that assesses the physical work environment has been added to the original version of the IT. 190 employees of the University of Trieste have been enrolled in the study. A confirmatory analysis showed a satisfactory fit of the eight-factors structure of the instrument. Further psychometric analysis showed adequate internal consistency of the IT scales and good criterion validity, as evidenced by the correlations with self-perception of stress, work satisfaction and motivation. In conclusion, the Indicator Tool proved to be a valid and reliable instrument for the assessment of work-related stress at the organizational level, and it is also compatible with the instructions provided by the Ministry of Labour and Social Policy (Circular letter 18/11/2010).

  19. Band Gaps and Optical Spectra of Chlorographene, Fluorographene and Graphane from G0W0, GW0 and GW Calculations on Top of PBE and HSE06 Orbitals.

    PubMed

    Karlický, František; Otyepka, Michal

    2013-09-10

    The band structures of three graphene derivatives (chlorographene, fluorographene, and graphane) were analyzed at three levels of many-body GW theory (G0W0, GW0, and GW) constructed over GGA (PBE) and screened hybrid HSE06 orbitals. DFT band gap values obtained with the HSE06 functional were notably larger than those from PBE calculations but were significantly lower than band gaps from all GW calculations. On the other hand, all GW-type calculations gave similar band gaps despite some differences in band structures. The band gap (4.9 eV at the highest GW-HSE06 level) was predicted to be smaller than that of fluorographene (8.3 eV) or graphane (6.2 eV). However, chlorographene can be considered a wide-band gap insulator analogous to fluorographene and graphane. Using the Bethe-Salpeter equation, optical absorptions of graphene derivatives were found to be at significantly lower energies due to large binding energies of excitons (1.3, 1.9, and 1.5 eV for chlorographene, fluorographene, and graphane, respectively). Point defects lowered band gaps and absorption energies. Taking into account the low concentration of defects in this type of material, their effect on the discussed electronic properties was rather small.

  20. Injection of new psychoactive substance snow blow associated with recently acquired HIV infections among homeless people who inject drugs in Dublin, Ireland, 2015.

    PubMed

    Giese, Coralie; Igoe, Derval; Gibbons, Zorina; Hurley, Caroline; Stokes, Siobhan; McNamara, Sinead; Ennis, Orla; O'Donnell, Kate; Keenan, Eamon; De Gascun, Cillian; Lyons, Fiona; Ward, Mary; Danis, Kostas; Glynn, Ronan; Waters, Allison; Fitzgerald, Margaret

    2015-01-01

    In February 2015, an outbreak of recently acquired HIV infections among people who inject drugs (PWID) was identified in Dublin, following similar outbreaks in Greece and Romania in 2011. We compared drug and risk behaviours among 15 HIV cases and 39 controls. Injecting a synthetic cathinone, snow blow, was associated with recent HIV infection (AOR: 49; p=0.003). Prevention and control efforts are underway among PWID in Dublin, but may also be needed elsewhere in Europe.

  1. Antibody response and protection against challenge in mice vaccinated intraperitoneally with a live aroA O4-O9 hybrid Salmonella dublin strain.

    PubMed Central

    Lindberg, A A; Segall, T; Weintraub, A; Stocker, B A

    1993-01-01

    An auxotrophic Salmonella dublin (O9,12) strain, SL5631, with a deletion affecting gene aroA, was made into a partial diploid expressing the rfb (O-antigen-repeat-unit-specifying) gene cluster of Salmonella typhimurium (O4,12). By use of O4- and O9-specific antisera in indirect immunofluorescence assays, the resulting hybrid SL7103 was shown to express both the O4- and O9-antigen epitopes in the same bacterium. Qualitative and quantitative sugar analyses by gas-liquid chromatography on peralditol acetates of phenol-water-extracted lipopolysaccharides showed that the S. dublin and S. typhimurium repeating units (estimated on the basis of their tyvelose and abequose contents, respectively) were present in approximately equimolar amounts. The SL7103 hybrid auxotroph was avirulent when given intraperitoneally to NMRI mice in a dose of 10(8) CFU and elicited a protective immunity against intraperitoneal challenge with either virulent S. dublin (50% lethal dose of ca. 1.5 x 10(4) CFU versus < 1 x 10(1) CFU in nonimmunized mice) or virulent S. typhimurium (50% lethal dose of ca. 1 x 10(5) versus < 1 x 10(1) CFU in nonimmunized mice). Compared with the protection elicited in homologous systems (S. dublin SL5631 against S. dublin and S. typhimurium SL1479 against S. typhimurium), the protective efficacy of the hybrid was reduced approximately 70-fold against S. dublin challenge and 100-fold against S. typhimurium challenge. Vaccination with S. typhimurium SL1479 conferred no protection against S. dublin challenge, and vaccination with S. dublin SL5631 conferred no protection against S. typhimurium challenge. The protection elicited by the hybrid strain SL7103 is supposed to be mainly a consequence of serum antibodies directed against the immunodominant O4 and O9 epitopes. PMID:7681041

  2. An outbreak of Salmonella dublin infection in England and Wales associated with a soft unpasteurized cows' milk cheese.

    PubMed Central

    Maguire, H.; Cowden, J.; Jacob, M.; Rowe, B.; Roberts, D.; Bruce, J.; Mitchell, E.

    1992-01-01

    An outbreak of Salmonella dublin infection occurred in England and Wales in October to December 1989. Forty-two people were affected, mainly adults, and most lived in south-east England. Microbiological and epidemiological investigations implicated an imported Irish soft unpasteurized cows' milk cheese as the vehicle of infection. A case-control study showed a statistically significant association between infection and consumption of the suspect cheese (p = 0.001). Salmonella dublin was subsequently isolated from cheeses obtained from the manufacturer's premises. Initial control measures included the withdrawal of the cheese from retail sale and a Food Hazard Warning to Environmental Health Departments, as well as a press release, from the Department of Health. Subsequently, a decision was taken by the manufacturer to pasteurize milk used in the production of cheese for the UK market and importation of the cheese resumed in June 1990. PMID:1468523

  3. Chemical Exchange Between the Core and the Convecting Mantle of the Earth: Evidence from Highly Siderophile Elements (HSE)

    NASA Astrophysics Data System (ADS)

    Schmidt, G.; Palme, H.; Kratz, K. L.

    1995-09-01

    Core formation is a major physical and chemical event in the evolution of a differentiated planet. The core is the dominant repository of HSE in the Earth. Element ratios of HSE in peridotites provide insights into the accretion processes of the Earth and the effect of core formation. Depletion of HSE in the Earth's mantle results from core formation. Refractory siderophile elements are about a factor of > 100 depleted in the Earth's mantle compared to CI carbonaceous chondrites. Nevertheless, the concentrations of PGE, Re and Au (7.1 +/- 0.8 x 10^-3 CI chondrite abundances) are higher than would be expected from metal-silicate partitioning during core formation [1]. Several different explanations have been suggested to explain the low absolute abundances of these elements. (1) Os, Re, Ir, Ru, Rh, Pd, Pt, and Au were added with a late chondritic veneer containing less than 1% of a CI component [2-9]. (2) Insufficient core formation, i.e. some metallic Fe-Ni was retained in the upper mantle during core formation [10]. (3) Disequilibrium during core formation; Segregation of metal from the upper mantle in later stages of accretion was so rapid that equilibrium was not attained [4,11,12]. (4) There was continuous formation of the core during accretion; Equilibrium between sinking metal grains and a molten magma ocean at high temperatures (3000-3500 K) [13]. (5) Increase in silicate/metal partition coefficients by pressure, temperature, or high f(O2) [5,14]; Solution of FeO in the core raises the f(O2) conditions at the core-mantle interface sufficiently to increase the equilibrium concentrations of the siderophile elements in the mantle [15]. Studies of mantle-derived samples such as massif peridotites and peridotite xenoliths provide direct information on the nature and composition of the upper mantle. Massive peridotitic rocks from Zabargad island (Red Sea), Lanzo (Italy), Ronda (Spain) and peridotitic xenoliths from Mongolia were analysed for Os, Re, Ir, Ru, Rh, Pd

  4. Continuous high-frequency monitoring of estuarine water quality as a decision support tool: a Dublin Port case study.

    PubMed

    Briciu-Burghina, Ciprian; Sullivan, Timothy; Chapman, James; Regan, Fiona

    2014-09-01

    High-frequency, continuous monitoring using in situ sensors offers a comprehensive and improved insight into the temporal and spatial variability of any water body. In this paper, we describe a 7-month exploratory monitoring programme in Dublin Port, demonstrating the value of high-frequency data in enhancing knowledge of processes, informing discrete sampling, and ultimately increasing the efficiency of port and environmental management. Kruskal-Wallis and Mann-Whitney tests were used to show that shipping operating in Dublin Port has a small-medium effect on turbidity readings collected by in situ sensors. Turbidity events are largely related to vessel activity in Dublin Port, caused by re-suspension of sediments by vessel propulsion systems. The magnitudes of such events are strongly related to water level and tidal state at vessel arrival times. Crucially, measurements of Escherichia coli and enterococci contamination from discrete samples taken at key periods related to detected turbidity events were up to nine times higher after vessel arrival than prior to disturbance. Daily in situ turbidity patterns revealed time-dependent water quality "hot spots" during a 24-h period. We demonstrate conclusively that if representative environmental assessment of water quality is to be performed at such sites, sampling times, informed by continous monitoring data, should take into account these daily variations. This work outlines the potential of sensor technologies and continuous monitoring, to act as a decision support tool in both environmental and port management.

  5. IRETHERM: Multidimensional geophysical modeling of the southern margin of the Dublin Basin

    NASA Astrophysics Data System (ADS)

    Vozar, Jan; Jones, Alan G.; Rath, Volker; Campanya, Joan; Pasquali, Riccardo

    2015-04-01

    Multi-dimensional magnetotelluric (MT) modelling of data from the Newcastle area west of Dublin, acquired as part of the geothermal potential of Ireland (IRETHERM) project, is presented. The Newcastle area, situated on the southern margin of the Carboniferous Dublin Basin, exhibits elevated geothermal gradient (>30 ° C/km) in the exploratory boreholes drilled by GT Energy. The MT soundings were carried out in the highly urbanized Dublin suburb and are heavily noise-contaminated and distorted due to EM noise from nearby industry and the DC tram system (LUAS). We obtained reliable and interpretable MT impedance and geomagnetic transfer functions at most sites by processing the 'quietest' 4-hour night time subsets of data using several robust codes and the ELICIT method. Tensor decomposition was applied at each site to ascertain if the data are suitable for 2-D modelling and to determine the appropriate geoelectric strike direction. The obtained 2-D models underwent examination using a new stability technique, and the final two 2-D profiles with reliability estimations, expressed through conductance and resistivity, were derived. 3-D models, including all usable MT data in the Newcastle area, have also been determined with and without resistivity constrains for shallow structures from resistivity measurements in one of the boreholes (borehole NGE1). The 3-D models exhibit structures with higher conductivity in comparison to the 2-D models, with similarly resistive background rocks. The shallow conductive structures, to a depth of 1 km, have north-south elongations correlated with the surface traces of faults that are perpendicular to the regional Blackrock to Newcastle Fault (BNF). Deeper structures become more oriented to a regional geoelectric strike similar to 2-D regional strike. To obtain superior characterization of the thermal transport properties of the investigated area, we used porosity and resistivity data from borehole NGE1 to estimate relation between

  6. Oral vaccination of calves with an aromatic-dependent Salmonella dublin (O9,12) hybrid expressing O4,12 protects against S. dublin (O9,12) but not against Salmonella typhimurium (O4,5,12).

    PubMed Central

    Segall, T; Lindberg, A A

    1993-01-01

    Three groups of six calves each, 5 to 7 weeks old, were orally vaccinated with the live aromatic-dependent delta aroA Salmonella dublin (O9,12) hybrid strain SL7103 with the O4,12-specifying rfb gene cluster from Salmonella typhimurium. SL7103 was given in three weekly doses, increasing from 2 x 10(9) to 1 x 10(11) bacteria per ml, was well tolerated, and caused mild, short-term temperature increases which diminished with each immunization. The strain was shed for up to 1 week. Strain SL7103 elicited significant (P < 0.001) and equal anti-S. dublin and -S. typhimurium lipopolysaccharide serum antibody responses and skin delayed-type hypersensitivity immune responses. Six vaccinated calves orally challenged with 10(10) CFU (equivalent to 1,000 50% lethal doses) of the virulent parent strain S. dublin SVA47 were protected and experienced only transient fever and mild mucoid diarrhea. However, six vaccinated calves orally challenged with 3 x 10(9) CFU and another six challenged with 3 x 10(8) CFU (equivalent to 1,000 50% lethal doses) of the virulent S. typhimurium SVA44 became bacteremic with a profuse hemorrhagic diarrhea and had to be sacrificed within 2 to 7 days. The results suggest that the S. typhimurium antilipopolysaccharide immunity was insufficient to provide a solid protective efficacy against oral S. typhimurium infection. The immunohistopathological examination revealed that S. typhimurium SVA44 could be found in all layers of the intestinal mucosa and the lymphatic tissues of the Peyer's patches. In contrast, S. dublin SVA47 was found predominantly in the columnar enterocytes of the jejunum and ileum and the follicle-associated epithelium over the Peyer's patches. In addition, SVA47 was found in the glandular tissues of the duodenal and tonsillar areas and in the lungs. This suggests that the S. typhimurium and S. dublin strains have different virulence traits determining their tissue localization and dissemination. Images PMID:7681042

  7. The Molecular Epidemiology of Resistance in Cefotaximase-Producing Escherichia coli Clinical Isolates from Dublin, Ireland.

    PubMed

    Burke, Liam; Humphreys, Hilary; Fitzgerald-Hughes, Deirdre

    2016-10-01

    In view of continued high clinical prevalence of infections involving extended-spectrum β-lactamase (ESBL)-producing Escherichia coli, this study sought to characterise the blaCTX-M genes, their associated mobile genetic elements and the integrons present in 100 ESBL-producing E. coli isolates collected in a Dublin hospital and associated community healthcare facilities. Polymerase chain reaction (PCR) mapping and sequencing was used to detect blaCTX-M alleles, their associated insertion sequences (ISs) and class 1 and 2 integrons in the collection. ESBL plasmids were characterised by PCR-based replicon typing and replicon sequence typing (RST). Cefotaximases were harboured by 94% of isolates (66 blaCTX-M-15, 8 blaCTX-M-14, 7 blaCTX-M-1, 4 blaCTX-M-3, 3 blaCTX-M-9, 2 blaCTX-M-27, 2 blaCTX-M-55, 1 blaCTX-M-32 and 1 blaCTX-M-2). An ISEcp1 promoter was linked to a group 1 blaCTX-M gene in 45% of isolates. A further 34% of isolates contained blaCTX-M-15 downstream of IS26, an arrangement typical of epidemic UK strain A. Class 1 integrons were found in 66% of isolates, most carrying trimethoprim/aminoglycoside resistance genes. CTX-M plasmids were primarily of multireplicon IncF or IncI1 type, but IncN and unidentified types were also found. Novel IncF RSTs F1:A-:B-, F45:A1:B-, F45:A4:B- and a novel IncI1 sequence type, ST159, were identified. CTX-M plasmids and integrons resembled those identified recently in animal isolates from Ireland and Western Europe. The molecular epidemiology of CTX-M-producing E. coli in Dublin suggests that horizontal spread of mobile genetic elements contributes to antimicrobial resistant human infections. Further investigations into whether animals or animal products represent an important local reservoir for these elements are warranted.

  8. High frequency Receiver Functions in the Dublin Basin: application to a potential geothermal site

    NASA Astrophysics Data System (ADS)

    Licciardi, Andrea; Piana Agostinetti, Nicola

    2014-05-01

    The Dublin Basin (DB) is a Carboniferous sedimentary basin located in the eastern part of Ireland, SW of Dublin. In the last years, the SW margin of the basin has been the object of interest for geothermal exploration, which led to the acquisition of two reflection seismic lines and the drilling of two ~ 1.4 km deep boreholes, from which a temperature of 130° C at ~4 km depth has been estimated. This deep geothermal potential of the DB is strictly related to SW basin-bounding Blackrock-Newcastle Fault (BNF) and the associated fault system. This fault runs in a NW-SE direction and separates the Carboniferous deposits that fill the basin from the Lower Paleozoic basement rocks which constitute the SW margin. In the framework of the SIM-CRUST project, four broadband seismic stations equipped with a Guralp CMG-6TD sensor have been deployed across the southwestern margin of the basin between July and August 2013, with an inter-station distance of about 1km. This closely spaced array has been designed to cross the BNF almost perpendicular. The main aim of this work is to recover the seismic stratigraphy of the shallow crust (0-8 km depth range) and determine the geometry of the BNF, by making use of the teleseismic Receiver Function (RF) method. This technique has been classically applied in seismology to image deep Earth's structure, but recent works have shown that it can also be used to retrieve information on the shallow part of the crust, just by increasing the frequency content in the analyzed RFs with little or no modifications to the preexisting analysis codes. We calculated a set of RFs for each station, progressively increasing the frequency from 0.5 up to 10 Hz. This is expected to dramatically increase the vertical resolution in the case of a good S/N ratio in the RFs. By stacking different RFs from a large set of epicentral distance and backazimuth incoherent signals are ruled out and true conversion are enhanced. Preliminary results show the presence of

  9. IRETHERM: Geophysical modeling of the southern margin of the Dublin Basin

    NASA Astrophysics Data System (ADS)

    Vozar, J.; Jones, A. G.; Llovet, J. C.; Pasquali, R.

    2014-12-01

    Multi-dimensional magnetotelluric (MT) modelling of data collected in the Newcastle area are presented in the frame of the IRETHERM project. The Newcastle area, situated on the southern margin of the Dublin Basin, exhibits elevated geothermal gradient (>30 °C/km) in the exploratory boreholes drilled by GT Energy. The MT soundings were carried out in the highly urbanized Dublin suburb and are heavily noise-contaminated and distorted due to EM noise from nearby industry and the DC tram system. Processing the "quietest" 4-hour night time subsets of data using several robust codes and the ELICIT method we obtained reliable and interpretable MT impedance and geomagnetic transfer functions at most sites. Tensor decomposition was applied at each site to ascertain if the data are suitable for 2D modelling and to determine the appropriate geoelectric strike direction. The final 2-D models underwent examination using a new stability technique, and the final two 2-D profiles with reliability estimations, expressed through conductance and resistivity, were derived. 3-D models of all MT data in the Newcastle area have also been determined. The 3-D models exhibit higher conductive structures in comparison to the 2-D models, with similarly resistive background rocks. The shallow conductive structures, to the depth of 1 km, have north-south elongation correlated with surface traces of faults, which are perpendicular to the regional Blackrock to Newcastle Fault (BNF). Deeper structures become more oriented to regional geoelectric strike similar to 2-D regional strike. The 2-D and 3-D modeling reveal that the BNF is imaged as a conductive zone to depths of 4 km and is likely highly fractured. Generally, the area south of the BNF is more resistive and compact with a horizontal conductive layer at approximately 1 km depth and with a very thin surficial sedimentary layer. In contrast, the structures north of the BNF are more heterogeneous, with deeper conductive layers (2-3 km depth

  10. Role of two-component sensory systems of Salmonella enterica serovar Dublin in the pathogenesis of systemic salmonellosis in cattle.

    PubMed

    Pullinger, Gillian D; van Diemen, Pauline M; Dziva, Francis; Stevens, Mark P

    2010-10-01

    Salmonella enterica serovar Dublin (S. Dublin) is associated with enteritis, typhoid and abortion in cattle. Infections are acquired by the oral route, and the bacteria transit through varied anatomical and cellular niches to elicit systemic disease. S. Dublin must therefore sense and respond to diverse extrinsic stimuli to control gene expression in a spatial and temporal manner. Two-component systems (TCSs) play key roles in such processes, and typically contain a membrane-associated sensor kinase (SK) that modifies a cognate response regulator. Analysis of the genome sequence of S. Dublin identified 31 conserved SK genes. Each SK gene was separately disrupted by lambda Red recombinase-mediated insertion of transposons harbouring unique sequence tags. Calves were challenged with a pool of the mutants together with control strains of defined virulence by the oral and intravenous routes. Quantification of tagged mutants in output pools derived from various tissues and cannulated lymphatic vessels allowed the assignment of spatial roles for each SK following oral inoculation or when the intestinal barrier was bypassed by intravenous delivery. Mutant phenotypes were also assigned in cultured intestinal epithelial cells. Mutants with insertions in barA, envZ, phoQ, ssrA or qseC were significantly negatively selected at all enteric and systemic sites sampled after oral dosing. Mutants lacking baeS, dpiB or citA were negatively selected at some but not all sites. After intravenous inoculation, only barA and phoQ mutants were significantly under-represented at systemic sites. The novel role of baeS in intestinal colonization was confirmed by oral co-infection studies, with a mutant exhibiting modest but significant attenuation at a number of enteric sites. This is the first systematic analysis of the role of all Salmonella TCSs in a highly relevant model of enteric fever. Spatial roles were assigned to eight S. Dublin SKs, but most were not essential for intestinal or

  11. Significance of the whole rock Re-Os ages in cryptically and modally metasomatised cratonic peridotites: Constraints from HSE-Se-Te systematics

    NASA Astrophysics Data System (ADS)

    Luguet, Ambre; Behrens, Melanie; Pearson, D. Graham; König, Stephan; Herwartz, Daniel

    2015-09-01

    The Re-Os isotopic system is the geochronometer of choice to constrain the timing of lithospheric mantle root formation and reconstruct the evolution of Earth's dynamics from the "mantle" perspective. In order to constrain the effects of metasomatic processes on the Re-Os isotopic system, eleven peridotites from the Letlhakane kimberlite pipe were investigated for whole rock major and trace elements, highly siderophile elements (HSE), Se, Te and 187Os/188Os signatures. These spinel peridotites (SP), garnet peridotites (GP), garnet-phlogopite peridotites (GPP) and phlogopite peridotites (PP) experienced cryptic metasomatism and the GP-GPP-PP additionally constitute a sequence of increasing modal metasomatism. The cryptically metasomatised SP appear devoid of base metal sulphides (BMS) and show suprachondritic Se/Te ratios (15-40) and extremely Pd- and Pt-depleted HSE patterns. These features are characteristic of high-degree partial melting residues. Their 187Os/188Os signatures are thus considered to be inherited from the partial melting event. This implies a Neoarchean (2.5-2.8 Ga, TRD eruption) stabilisation of the Letlhakane mantle root and supports the Letlhakane mantle root being a westerly extension of the Zimbabwe cratonic root. The modally metasomatised peridotites contain BMS whose abundance significantly increases from the GPP to the GP and PP. The BMS-poor GPP are only slightly richer in Pt and Pd than the BMS-free SP but have similarly high Se/Te ratios. The BMS-rich GP and PP exhibit significant enrichments in Pt, Pd, Se, Te resulting in HSE-Se-Te signatures similar to that of the Primitive Upper Mantle (PUM). Addition of 0.001-0.05 wt.% metasomatic BMS ± PGM (platinum group minerals, i.e., Pt-tellurides) to highly refractory residues, such as the Letlhakane SP, reproduce well the HSE-Se-Te systematics observed in the BMS-poor and BMS-rich modally metasomatised peridotites. In the GPP, the negligible addition of metasomatic BMS ± PGM did not disturb

  12. [Jonathan Swift's asylum in Dublin--Ireland's introduction to institutional psychiatry 250 years ago].

    PubMed

    Reuber, M

    1995-09-01

    250 years ago, the satirical writer and clergyman Jonathan Swift from Dublin (1667-1745) founded the first Irish lunatic asylum. Rejecting the theories put forward by the English philosopher Thomas Hobbes and the doctor Thomas Willis, he was influenced by the ideas of the Scottish doctor and the "enlightened" thinker John Locke. Swift's St. Patrick's Hospital did not, however, realise a new philosophical concept: architecture and therapeutic approach of the new institution were clearly modelled on the much older Hospital of St. Mary of Bethlehem ( = Bedlam). Despite its conservative conceptual basis, the first institution dedicated to the mentally ill and intellectually subnormal in Ireland became a starting point for the apparantly unstoppable expansion of the, at one time, most comprehensive asylum system in the world. After Swift's Hospital had been enlarged twice at the tax-payers' expense (1778, 1793), the administration decided to relieve the institution by erecting the Richmond Asylum (1810), the first public asylum in Ireland. When this establishment also became overcrowded, in 1817, legislation was passed which led to the establishment of the oldest system of public asylums in Europe.

  13. [Implementation and validation in the Italian context of the HSE management standards: a contribution to provide a practical model for the assessment of work-related stress].

    PubMed

    Iavicoli, S; Natali, E; Rondinone, B M; Castaldi, T; Persechino, B

    2010-01-01

    Over the last years, stress has been recognized as a potential work-related risk factor. Unfortunately, work-related stress is a very delicate subject, especially because it is difficult to assess it objectively and in broadly acceptable terms. In fact, work-related stress is a subjective personal response to a specific work environment, ad is of a multifactorial origin. In order to provide a practical tool for the assessment of work-related stress, the authors carried out a thorough benchmarking analysis of the various models to manage work stress problems adopted by EU countries. As a result, the authors have chosen to apply and implement the Health and Safety Executive (HSE) Management Standards approach in the Italian context. In compliance with the European Framework Agreement signed on October 8, 2004, HSE Management Standards ask for the coordinated and integrated involvement of workers and safety personnel and represent a valid assessment approach based on principles widely acknowledged in the scientific literature.

  14. Systematic study of the effect of HSE functional internal parameters on the electronic structure and band gap of a representative set of metal oxides.

    PubMed

    Viñes, Francesc; Lamiel-García, Oriol; Chul Ko, Kyoung; Yong Lee, Jin; Illas, Francesc

    2017-04-30

    The effect of the amount of Hartree-Fock mixing parameter (α) and of the screening parameter (w) defining the range separated HSE type hybrid functional is systematically studied for a series of seven metal oxides: TiO2 , ZrO2 , CuO2 , ZnO, MgO, SnO2 , and SrTiO3 . First, reliable band gap values were determined by comparing the optimal α reproducing the experiment with the inverse of the experimental dielectric constant. Then, the effect of the w in the HSE functional on the calculated band gap was explored in detail. Results evidence the existence of a virtually infinite number of combinations of the two parameters which are able to reproduce the experimental band gap, without a unique pair able to describe the full studied set of materials. Nevertheless, the results point out the possibility of describing the electronic structure of these materials through a functional including a screened HF exchange and an appropriate correlation contribution. © 2017 Wiley Periodicals, Inc.

  15. Metal ions induced heat shock protein response by elevating superoxide anion level in HeLa cells transformed by HSE-SEAP reporter gene.

    PubMed

    Yu, Zhanjiang; Yang, Xiaoda; Wang, Kui

    2006-06-01

    The aim of this work is to define the relationship between heat shock protein (HSP) and reactive oxygen species (ROS) in the cells exposed to different concentrations of metal ions, and to evaluate a new method for tracing the dynamic levels of cellular reactive oxygen species using a HSE-SEAP reporter gene. The expression of heat shock protein was measured using a secreted alkaline phosphatase (SEAP) reporter gene transformed into HeLa cell strain, the levels of superoxide anion (O(2)(-)) and hydrogen peroxide (H(2)O(2)) were determined by NBT reduction assay and DCFH staining flow cytometry (FCM), respectively. The experimental results demonstrated that the expression of heat shock protein induced by metal ions was linearly related to the cellular superoxide anion level before cytotoxic effects were observed, but not related to the cellular hydrogen peroxide level. The experimental results suggested that metal ions might induce heat shock protein by elevating cellular superoxide anion level, and thus the expression of heat shock protein indicated by the HSE-SEAP reporter gene can be an effective model for monitoring the dynamic level of superoxide anion and early metal-induced oxidative stress/cytotoxicity.

  16. Synthesis, crystal structure determination, thermal and magnetic properties of the new Cu0.73Ni0.27(HSeO3)2 compound

    NASA Astrophysics Data System (ADS)

    Hentech, I.; Zehani, K.; Kabadou, A.; Ben Salah, A.; Loukil, M.; Bessais, L.

    2017-01-01

    A novel three-dimensional Cu0.73Ni0.27(HSeO3)2 compound was prepared from an aqueous solution. This compound crystallizes in the monoclinic system with P21/n space group and with the following cell parameters: a=6.4379(3) Å; b=7.3555(3) Å; c=5.7522(3) Å; β=93.4341(1)°; V=271.90(2) Å3 and Z=2. The reported material has been structurally characterized by X-ray powder diffraction and confirmed by scanning electron microscope and energy dispersive spectroscopy (MEB/EDS) analysis. The copper/nickel atom is surrounded by an octahedron coordination of oxygen atoms from sex hydrogenoselenites anions. The presence of (HSeO3)- has been further confirmed by IR spectroscopy and this compound exhibits a phase transition at 356 K, this transition has been detected by differential scanning calorimetry and TG-DTA measurement. The magnetic property of this material was determined. The ferromagnetic ordering is further confirmed by the magnetic field dependence of the magnetization (Hysteresis loop) at 10 K. The substitution of Cu by Ni induces a ferro-paramagnetic transition at T=31 K. Field cooled (FC) and Zero field cooled (ZFC) magnetization measurements under an applied field of 100 Oe in the temperature range of 10-300 K were performed. These measurements have been resulted the blocking temperature (TB) at around 25 K.

  17. Attitudes and behaviour towards waste management in the Dublin, Ireland region.

    PubMed

    Purcell, M; Magette, W L

    2010-10-01

    The hypothesis of this research was that attitudes about the management of biodegradable municipal waste (BMW) are spatially variable, even within a city of modest (1.2 million) population. For a select number of representative electoral districts in the Dublin, Ireland region, residents were surveyed regarding attitudes towards waste management in general, and BMW management in particular. A total of 850 survey responses were collected. Door-to-door interviews produced 688 responses in the residential sector; these were supplemented by 162 responses to a web-based survey. The surveys revealed that the majority of households use local authority, rather than private, waste collection services (both are available). The majority of residents, regardless of the local authority in which they live, were satisfied with their waste management service. "Reducing the quantity of waste generated" was regarded the most important future issue for 28% of residential respondents. Statistical analyses of the survey responses showed that the local authority in which respondents resided significantly influenced most responses (including waste collection service used, waste service satisfaction and backyard composting activity). Many responses (including waste service satisfaction, waste management influences) were also significantly related to the respondents' personal characteristics (e.g., education level, type of accommodation, age, etc.). These statistical results proved the hypothesis of the research and demonstrated that waste management initiatives designed for one area of the city (or, indeed, for uniform application to the city as a whole) could ignore the needs of other areas. The survey responses suggest that targeted intervention strategies would lead to improved diversion rates of BMW from landfill, a requirement of the Landfill Directive 1999/31/EC.

  18. Probiotic effect on calves infected with Salmonella Dublin: haematological parameters and serum biochemical profile.

    PubMed

    Soto, L P; Astesana, D M; Zbrun, M V; Blajman, J E; Salvetti, N R; Berisvil, A P; Rosmini, M R; Signorini, M L; Frizzo, L S

    2016-02-01

    The aim of this study was to evaluate the effect of a probiotic/lactose inoculum on haematological and immunological parameters and renal and hepatic biochemical profiles before and during a Salmonella Dublin DSPV 595T challenge in young calves. Twenty eight calves, divided into a control and probiotic group were used. The probiotic group was supplemented with 100 g lactose/calf/d and 10(10) cfu/calf/d of each strain of a probiotic inoculum composed of Lactobacillus casei DSPV318T, Lactobacillus salivarius DSPV315T and Pediococcus acidilactici DSPV006T throughout the experiment. The pathogen was administered on day 11 of the experiment, at an oral dose of 10(9) cfu/animal (LD50). Aspartate aminotransferase (AST), gamma glutamyl transpeptidase (GGT), urea, red blood cells, haemoglobin, haematocrit, mean cell haemoglobin (MCH), mean corpuscular volume, mean corpuscular haemoglobin concentration (MCHC), white blood cells, lymphocytes, neutrophils, band neutrophils, monocytes, eosinophils, basophils and the neutrophils/lymphocytes ratio were measured on days 1, 10, 20 and 27 of the experiment. In addition, animals were necropsied to evaluate immunoglobulin A (IgA) production in the jejunal mucosa. The most significant differences caused by the administration of the inoculum/lactose were found during the acute phase of Salmonella challenge (9 days after challenge), when a difference between groups in neutrophils/lymphocytes ratio were detected. These results suggest that the probiotic/lactose inoculum administration increases the calf's ability to respond to the disease increasing the systemic immune response specific. No differences were found in haemoglobin, haematocrit, MCH, MCHC, AST, urea, GGT, band neutrophils, eosinophils, monocytes and IgA in the jejunum between the two groups of calves under the experimental conditions of this study. Further studies must be conducted to evaluate different probiotic/pathogens doses and different sampling times, to achieve a

  19. Repression of Flagella Is a Common Trait in Field Isolates of Salmonella enterica Serovar Dublin and Is Associated with Invasive Human Infections

    PubMed Central

    Sasías, Sebastián; Martínez, Arací; Betancor, Laura; Estevez, Verónica; Scavone, Paola; Bielli, Alejandro; Sirok, Alfredo; Chabalgoity, José Alejandro

    2014-01-01

    The nontyphoidal Salmonella enterica serovar Dublin is adapted to cattle but infrequently infects humans, very often resulting in invasive infections with high levels of morbidity and mortality. A Salmonella-induced intestinal acute inflammatory response is postulated as a mechanism to prevent bacterial dissemination to systemic sites. In S. enterica serovar Typhimurium, flagella contribute to this response by providing motility and FliC-mediated activation of pattern recognition receptors. In this study, we found 4 Salmonella enterica isolates, with the antigenic formula 9,12:−:−, that, based on fliC sequence and multilocus sequence type (MLST) analyses, are aflagellate S. Dublin isolates. Interestingly, all were obtained from human bloodstream infections. Thus, we investigated the potential role of flagella in the unusual invasiveness exhibited by S. Dublin in humans by analyzing flagellation and proinflammatory properties of a collection of 10 S. Dublin human clinical isolates. We found that 4 of 7 blood isolates were aflagellate due to significantly reduced levels of fliC expression, whereas all 3 isolates from other sources were flagellated. Lack of flagella correlated with a reduced ability of triggering interleukin-8 (IL-8) and CCL20 chemokine expression in human intestinal Caco-2 cells and with reduced early inflammation in the ceca of streptomycin-pretreated C57/BL6 mice. These results indicate that flagella contribute to the host intestinal inflammatory response to Salmonella serovar Dublin and suggest that their absence may contribute to its systemic dissemination through dampening of the gut immune response. Analysis of FliC production in a collection of cattle isolates indicated that the aflagellate phenotype is widely distributed in field isolates of S. Dublin. PMID:24421045

  20. Repression of flagella is a common trait in field isolates of Salmonella enterica serovar Dublin and is associated with invasive human infections.

    PubMed

    Yim, Lucía; Sasías, Sebastián; Martínez, Arací; Betancor, Laura; Estevez, Verónica; Scavone, Paola; Bielli, Alejandro; Sirok, Alfredo; Chabalgoity, José Alejandro

    2014-04-01

    The nontyphoidal Salmonella enterica serovar Dublin is adapted to cattle but infrequently infects humans, very often resulting in invasive infections with high levels of morbidity and mortality. A Salmonella-induced intestinal acute inflammatory response is postulated as a mechanism to prevent bacterial dissemination to systemic sites. In S. enterica serovar Typhimurium, flagella contribute to this response by providing motility and FliC-mediated activation of pattern recognition receptors. In this study, we found 4 Salmonella enterica isolates, with the antigenic formula 9,12:-:-, that, based on fliC sequence and multilocus sequence type (MLST) analyses, are aflagellate S. Dublin isolates. Interestingly, all were obtained from human bloodstream infections. Thus, we investigated the potential role of flagella in the unusual invasiveness exhibited by S. Dublin in humans by analyzing flagellation and proinflammatory properties of a collection of 10 S. Dublin human clinical isolates. We found that 4 of 7 blood isolates were aflagellate due to significantly reduced levels of fliC expression, whereas all 3 isolates from other sources were flagellated. Lack of flagella correlated with a reduced ability of triggering interleukin-8 (IL-8) and CCL20 chemokine expression in human intestinal Caco-2 cells and with reduced early inflammation in the ceca of streptomycin-pretreated C57/BL6 mice. These results indicate that flagella contribute to the host intestinal inflammatory response to Salmonella serovar Dublin and suggest that their absence may contribute to its systemic dissemination through dampening of the gut immune response. Analysis of FliC production in a collection of cattle isolates indicated that the aflagellate phenotype is widely distributed in field isolates of S. Dublin.

  1. Hyper Text Mark-up Language and Dublin Core metadata element set usage in websites of Iranian State Universities’ libraries

    PubMed Central

    Zare-Farashbandi, Firoozeh; Ramezan-Shirazi, Mahtab; Ashrafi-Rizi, Hasan; Nouri, Rasool

    2014-01-01

    Introduction: Recent progress in providing innovative solutions in the organization of electronic resources and research in this area shows a global trend in the use of new strategies such as metadata to facilitate description, place for, organization and retrieval of resources in the web environment. In this context, library metadata standards have a special place; therefore, the purpose of the present study has been a comparative study on the Central Libraries’ Websites of Iran State Universities for Hyper Text Mark-up Language (HTML) and Dublin Core metadata elements usage in 2011. Materials and Methods: The method of this study is applied-descriptive and data collection tool is the check lists created by the researchers. Statistical community includes 98 websites of the Iranian State Universities of the Ministry of Health and Medical Education and Ministry of Science, Research and Technology and method of sampling is the census. Information was collected through observation and direct visits to websites and data analysis was prepared by Microsoft Excel software, 2011. Results: The results of this study indicate that none of the websites use Dublin Core (DC) metadata and that only a few of them have used overlaps elements between HTML meta tags and Dublin Core (DC) elements. The percentage of overlaps of DC elements centralization in the Ministry of Health were 56% for both description and keywords and, in the Ministry of Science, were 45% for the keywords and 39% for the description. But, HTML meta tags have moderate presence in both Ministries, as the most-used elements were keywords and description (56%) and the least-used elements were date and formatter (0%). Conclusion: It was observed that the Ministry of Health and Ministry of Science follows the same path for using Dublin Core standard on their websites in the future. Because Central Library Websites are an example of scientific web pages, special attention in designing them can help the researchers

  2. Hyper Text Mark-up Language and Dublin Core metadata element set usage in websites of Iranian State Universities' libraries.

    PubMed

    Zare-Farashbandi, Firoozeh; Ramezan-Shirazi, Mahtab; Ashrafi-Rizi, Hasan; Nouri, Rasool

    2014-01-01

    Recent progress in providing innovative solutions in the organization of electronic resources and research in this area shows a global trend in the use of new strategies such as metadata to facilitate description, place for, organization and retrieval of resources in the web environment. In this context, library metadata standards have a special place; therefore, the purpose of the present study has been a comparative study on the Central Libraries' Websites of Iran State Universities for Hyper Text Mark-up Language (HTML) and Dublin Core metadata elements usage in 2011. The method of this study is applied-descriptive and data collection tool is the check lists created by the researchers. Statistical community includes 98 websites of the Iranian State Universities of the Ministry of Health and Medical Education and Ministry of Science, Research and Technology and method of sampling is the census. Information was collected through observation and direct visits to websites and data analysis was prepared by Microsoft Excel software, 2011. The results of this study indicate that none of the websites use Dublin Core (DC) metadata and that only a few of them have used overlaps elements between HTML meta tags and Dublin Core (DC) elements. The percentage of overlaps of DC elements centralization in the Ministry of Health were 56% for both description and keywords and, in the Ministry of Science, were 45% for the keywords and 39% for the description. But, HTML meta tags have moderate presence in both Ministries, as the most-used elements were keywords and description (56%) and the least-used elements were date and formatter (0%). It was observed that the Ministry of Health and Ministry of Science follows the same path for using Dublin Core standard on their websites in the future. Because Central Library Websites are an example of scientific web pages, special attention in designing them can help the researchers to achieve faster and more accurate information resources

  3. The role of flagella and chemotaxis genes in host pathogen interaction of the host adapted Salmonella enterica serovar Dublin compared to the broad host range serovar S. Typhimurium

    PubMed Central

    2013-01-01

    Background The importance of flagella and chemotaxis genes in host pathogen interaction in Salmonella enterica is mainly based on studies of the broad host range serovar, S. Typhimurium, while little is known on the importance in host specific and host adapted serovars, such as S. Dublin. In the current study we have used previously characterized insertion mutants in flagella and chemotaxis genes to investigate this and possible differences in the importance between the two serovars. Results fliC (encoding the structural protein of the flagella) was essential for adhesion and fliC and cheB (CheB restores the chemotaxis system to pre-stimulus conformation) were essential for invasion of S. Dublin into epithelial Int407 cells. In S. Typhimurium, both lack of flagella (fliC/fljB double mutant) and cheB influenced adhesion, and invasion was influenced by lack of both cheA (the histidine-kinase of the chemotaxis system), fliC/fljB and cheB mutation. Uptake in J774A.1 macrophage cells was significantly reduced in cheA, cheB and fliC mutants of S. Dublin, while cheA was dispensable in S. Typhimurium. Removal of flagella in both serotypes caused an increased ability to propagate intracellular in J774 macrophage cells and decreased cytotoxicity toward these cells. Flagella and chemotaxis genes were found not to influence the oxidative response. The induction of IL-6 from J774A-1 cells depended on the presence of flagella in S. Typhimurium, whilst this was not the case following challenge with S. Dublin. Addition of fliC from S. Typhimurium in trans to a fliC mutant of S. Dublin increased cytotoxicity but it did not increase the IL-6 production. Flagella were demonstrated to contribute to the outcome of infection following oral challenge of mice in S. Dublin, while an S. Typhimurium fliC/fljB mutant showed increased virulence following intra peritoneal challenge. Conclusions The results showed that flagella and chemotaxis genes differed in their role in host pathogen

  4. Environmental consequences of a power plant shut-down: a three-dimensional water quality model of Dublin Bay.

    PubMed

    Bedri, Zeinab; Bruen, Michael; Dowley, Aodh; Masterson, Bartholomew

    2013-06-15

    A hydro-environmental model is used to investigate the effect of cessation of thermal discharges from a power plant on the bathing water quality of Dublin Bay. Before closing down, cooling water from the plant was mixed with sewage effluent prior to its discharge, creating a warmer, less-saline buoyant pollutant plume that adversely affects the water quality of Dublin Bay. The model, calibrated to data from the period prior to the power-plant shut-down (Scenario1), assessed the water quality following its shut-down under two scenarios; (i) Scenario2: continued abstraction of water to dilute sewage effluents before discharge, and (ii) Scnenario3: sewage effluents are discharged directly into the Estuary. Comparison between scenarios was based on distribution of Escherichia coli (E. coli), a main bathing quality indicator. Scenarios1 and 2, showed almost similar E. coli distribution patterns while Scenario3 displayed significantly higher E. coli concentrations due to the increased stratification caused by the lack of prior dilution.

  5. The importance of motility and chemotaxis for extra-animal survival of Salmonella enterica serovar Typhimurium and Dublin.

    PubMed

    Olsen, J E; Hoegh-Andersen, K H; Casadesús, J; Thomsen, L E

    2012-09-01

    This study investigated the importance of flagella and motility of Salmonella enterica serovar Typhimurium and Dublin in models of extra-animal survival. The study was performed using transposon mutants in flagella genes fliC and fljB and in chemotaxis genes cheA, cheB and cheR. Flagella and chemotaxis were found to be of minor importance for attachment to plant leaves, survival in liquid manure and interaction with the nematode C. elegans, while differences were observed between the fliC mutant and the wild-type strain of S. Dublin in interactions with amoebae. The study shows that flagella and chemotaxis play a minor role in extra-animal survival of these two serovars of Salmonella under the conditions tested. Extra-animal survival is important in the full infection cycle for zoonotic salmonellae. Such serovars are motile. Even though the current study was only based on the characterization of two serovars, it strongly suggests that motility and chemotaxis are of minor importance during the spread of Salmonella from one animal to the next through the external environment. © 2012 The Authors Journal of Applied Microbiology © 2012 The Society for Applied Microbiology.

  6. Pt-Re-Os and Sm-Nd isotope and HSE and REE systematics of the 2.7 Ga Belingwe and Abitibi komatiites

    NASA Astrophysics Data System (ADS)

    Puchtel, I. S.; Walker, R. J.; Brandon, A. D.; Nisbet, E. G.

    2009-10-01

    High-precision Pt-Re-Os and Sm-Nd isotope and highly siderophile element (HSE) and rare earth element (REE) abundance data are reported for two 2.7 b.y. old komatiite lava flows, Tony's flow (TN) from the Belingwe greenstone belt, Zimbabwe, and the PH-II flow (PH) from Munro Township in the Abitibi greenstone belt, Canada. The emplaced lavas are calculated to have contained ˜25% (TN) and ˜28% (PH) MgO. These lavas were derived from mantle sources characterized by strong depletions in highly incompatible lithophile trace elements, such as light REE (Ce/Sm N = 0.64 ± 0.02 (TN) and 0.52 ± 0.01 (PH), ɛ 143Nd(T) = +2.9 ± 0.2 in both sources). 190Pt- 186Os and 187Re- 187Os isochrons generated for each flow yield ages consistent with respective emplacement ages obtained using other chronometers. The calculated precise initial 186Os/ 188Os = 0.1198318 ± 3 (TN) and 0.1198316 ± 5 (PH) and 187Os/ 188Os = 0.10875 ± 17 (TN) and 0.10873 ± 15 (PH) require time-integrated 190Pt/ 188Os and 187Re/ 188Os of 0.00178 ± 11 and 0.407 ± 8 (TN) and 0.00174 ± 18 and 0.415 ± 5 (PH). These parameters, which by far represent the most precise and accurate estimates of time-integrated Pt/Os and Re/Os of the Archean mantle, are best matched by those of enstatite chondrites. The data also provide evidence for a remarkable similarity in the composition of the sources of these komatiites with respect to both REE and HSE. The calculated absolute HSE abundances in the TN and PH komatiite sources are within or slightly below the range of estimates for the terrestrial Primitive Upper Mantle (PUM). Assuming a chondritic composition of the bulk silicate Earth, the strong depletions in LREE, yet chondritic Re/Os in the komatiite sources are apparently problematic because early Earth processes capable of fractionating the LREE might also be expected to fractionate Re/Os. This apparent discrepancy could be reconciled via a two-stage model, whereby the moderate LREE depletion in the sources of

  7. The Impact of Problem-Based Learning on the Information Behavior and Literacy of Veterinary Medicine Students at University College Dublin

    ERIC Educational Resources Information Center

    Dodd, Lorna

    2007-01-01

    Research was conducted on the impact of Problem-Based Learning (PBL) on the information seeking and literacy of veterinary students at University College Dublin. Data were collected using both quantitative and qualitative methods from students, academics and the librarian. Results showed that PBL has a significant impact on how students find and…

  8. Use of a geographic information system to map cases of measles in real-time during an outbreak in Dublin, Ireland, 2011.

    PubMed

    Fitzpatrick, G; Ward, M; Ennis, O; Johnson, H; Cotter, S; Carr, M J; O Riordan, B; Waters, A; Hassan, J; Connell, J; Hall, W; Clarke, A; Murphy, H; Fitzgerald, M

    2012-12-06

    In 2011, there was a large measles outbreak in Dublin. Nationally 285 cases were notified to the end of December 2011, and 250 (88%) were located in the Dublin region. After the first case was notified in week 6, numbers gradually increased, with 25 notified in June and a peak of 53 cases in August. Following public health intervention including a measles-mumps-rubella (MMR) vaccination campaign, no cases were reported in the Dublin region in December 2011. Most cases (82%) were children aged between 6 months and 14 years, and 46 cases (18%) were under 12 months-old. This is the first outbreak in Dublin to utilise a geographic information system for plotting measles cases on a digital map in real time. This approach, in combination with the analysis of case notifications, assisted the department of public health in demonstrating the extent of the outbreak. The digital mapping documented the evolution of two distinct clusters of 87 (35%) cases. These measles cases were infected with genotype D4-Manchester recently associated with large outbreaks across Europe. The two clusters occurred in socio-economically disadvantaged areas and were attributable to inadequate measles vaccination coverage due in part to the interruption of a school-based MMR2 vaccination programme.

  9. A Scaled-Up Model of AP(E)L for Sectoral Professionalisation: Lessons from the 2005 Valex Pilot Project (Dublin)

    ERIC Educational Resources Information Center

    Murphy, Anne

    2007-01-01

    This paper outlines the policy and pedagogical outcomes of an AP(E)L Pilot Project in the social care sector undertaken as an element of the 2003-2005 Socrates-Grundtvig Research Project: VaLEx Valuing Learning from Experience, by the Dublin Institute of Technology (DIT) and the Open Training College (OTC). It deals with the experiences of the two…

  10. The Museum of Irish Industry, Robert Kane and Education for All in the Dublin of the 1850s and 1860s

    ERIC Educational Resources Information Center

    Cullen, Clara

    2009-01-01

    The Museum of Irish Industry in Dublin, in its short existence (1845-1867) facilitated the access of ordinary people to popular scientific education, became a "cause celebre" and was defended by popular protest when the government recommended its abolition in 1862. Its Director, Sir Robert Kane (1809-1890) was not only an advocate of…

  11. The Impact of Problem-Based Learning on the Information Behavior and Literacy of Veterinary Medicine Students at University College Dublin

    ERIC Educational Resources Information Center

    Dodd, Lorna

    2007-01-01

    Research was conducted on the impact of Problem-Based Learning (PBL) on the information seeking and literacy of veterinary students at University College Dublin. Data were collected using both quantitative and qualitative methods from students, academics and the librarian. Results showed that PBL has a significant impact on how students find and…

  12. "Click Here to Order This Book": A Case Study of Print and Electronic Patron-Driven Acquisition in University College Dublin

    ERIC Educational Resources Information Center

    Tynan, Mark; McCarney, Eoin

    2014-01-01

    University College Dublin became the first library in the Republic of Ireland to trial patron-driven acquisition (PDA) as a collection development tool in 2013. A total of 42% of UCD Library's book budget was allocated to the project, which included both electronic and print books. This article describes the twelve month project from the tender…

  13. A Common Model To Support Interoperable Metadata: Progress Report on Reconciling Metadata Requirements from the Dublin Core and INDECS/DOI Communities.

    ERIC Educational Resources Information Center

    Bearman, David; Rust, Godfrey; Weibel, Stuart; Miller, Eric; Trant, Jennifer

    1999-01-01

    The Dublin Core metadata community and the INDECS/DOI community of authors, rights holders, and publishers are seeking common ground in the expression of metadata for information resources. An open "Schema Harmonization" working group has been established to identify a common framework to support interoperability among these communities.…

  14. The Museum of Irish Industry, Robert Kane and Education for All in the Dublin of the 1850s and 1860s

    ERIC Educational Resources Information Center

    Cullen, Clara

    2009-01-01

    The Museum of Irish Industry in Dublin, in its short existence (1845-1867) facilitated the access of ordinary people to popular scientific education, became a "cause celebre" and was defended by popular protest when the government recommended its abolition in 1862. Its Director, Sir Robert Kane (1809-1890) was not only an advocate of…

  15. Neighbourhood Based Residential Child Care: A Local Residential Child Care Unit as a Resource for Integrated and Flexible Child and Family Care in Dublin.

    ERIC Educational Resources Information Center

    Gilligan, Robbie

    A pioneering residential child care project in inner city Dublin began operations in July 1981. The project was designed to function as a resource for seriously deprived or at-risk children and their families. The community served is one characterized by exceptionally high unemployment, a 10 percent rate of heroin addiction among local 15- to…

  16. The perception of place and the 'origins of handedness' debate: towards a cognitive cartography of science in late-Victorian Dublin.

    PubMed

    O'Sullivan, Tanya

    2015-01-01

    In 1884, a medical paper entitled 'Consideration of the Structural and Acquisitional Elements in Dextral Pre-Eminence' penned by the Dublin physician George Sigerson, appeared in the Proceedings of the Royal Irish Academy. A number of years later, the Journal of the Anthropological Institute of Great Britain and Ireland presented a similar piece by Dublin anatomist Daniel John Cunningham, on the topic of 'Right-Handedness and Left-Brainedness'. For the late nineteenth-century scientific community, these articles represented two Dublin-based contributions to a long-running and wide-ranging debate on the origins of handedness. However, by building on the geographical premise that scientific knowledge bears the imprint of its location and that place matters in the way scientific claims come to be sanctioned, this paper probes, not merely an encounter with evolutionary science in the less well explored domain of fin de siècle Dublin, but more crucially, how these local reviews of manual dexterity were in part shaped by the scientists' differing perceptions of their city. By attending to the lives of Sigerson and Cunningham and focusing on the interplay between life-space, city-space and science, it underscores the critical role of place and space in the reception, circulation and mobilisation of scientific knowledge in the city. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. "Click Here to Order This Book": A Case Study of Print and Electronic Patron-Driven Acquisition in University College Dublin

    ERIC Educational Resources Information Center

    Tynan, Mark; McCarney, Eoin

    2014-01-01

    University College Dublin became the first library in the Republic of Ireland to trial patron-driven acquisition (PDA) as a collection development tool in 2013. A total of 42% of UCD Library's book budget was allocated to the project, which included both electronic and print books. This article describes the twelve month project from the tender…

  18. Genetic diversity, anti-microbial resistance, plasmid profile and frequency of the Vi antigen in Salmonella Dublin strains isolated in Brazil.

    PubMed

    Vilela, F P; Frazão, M R; Rodrigues, D P; Costa, R G; Casas, M R T; Fernandes, S A; Falcão, J P; Campioni, F

    2017-09-24

    Salmonella Dublin is strongly adapted to cattle causing enteritis and/or systemic disease with high rates of mortality. However, it can be sporadically isolated from humans, usually causing serious disease, especially in patients with underlying chronic diseases. The aim of this study was to molecularly type S. Dublin strains isolated from humans and animals in Brazil to verify the diversity of these strains as well as to ascertain possible differences between strains isolated from humans and animals. Moreover, the presence of the capsular antigen Vi and the plasmid profile was characterized in addition to the anti-microbial resistance against 15 drugs. For this reason, 113 S. Dublin strains isolated between 1983 and 2016 from humans (83) and animals (30) in Brazil were typed by PFGE and MLVA. The presence of the capsular antigen Vi was verified by PCR, and the phenotypic expression of the capsular antigen was determined serologically. Also, a plasmid analysis for each strain was carried out. The strains studied were divided into 35 different PFGE types and 89 MLVA-types with a similarity of ≥80% and ≥17.5%, respectively. The plasmid sizes found ranged from 2 to >150 kb and none of the strains studied presented the capsular antigen Vi. Resistance or intermediate resistance was found in 23 strains (20.3%) that were resistant to ampicillin, ciprofloxacin, chloramphenicol, imipenem, nalidixic acid, piperacillin, streptomycin and/or tetracycline. The majority of the S. Dublin strains studied and isolated over a 33-year period may descend from a common subtype that has been contaminating humans and animals in Brazil and able to cause invasive disease even in the absence of the capsular antigen. The higher diversity of resistance phenotypes in human isolates, as compared with animal strains, may be a reflection of the different anti-microbial treatments used to control S. Dublin infections in humans in Brazil. © 2017 Blackwell Verlag GmbH.

  19. Development of an indexing search engine for the UMVF: proposal for an indexing method based on Dublin Core and XML.

    PubMed

    Mougin, Fleur; Cuggia, Marc; Le Beux, Pierre

    2003-01-01

    The UMVF (French Virtual Medical University) has many heterogeneous resources hosted by the servers of university partners of the project. One of its objectives is to develop an efficient tool to perform a single search on these resources. We first defined a standardized and interoperable indexing method. For each document, an XML file containing information on the fifteen elements of Dublin Core was created. We checked its structure and content with a DTD. If the XML file was valid, its data were then integrated into a central database from which the engine carried out a search. We tested our tool successfully with the resources hosted by the Rennes Laboratory of Medical Informatics in cooperation with the Radiology Medical Campus [1]. Our method allows the standardization of the production of information by the various servers and it conforms to the constraints of the semantic Web owing to the technologies chosen.

  20. Early medieval cattle remains from a Scandinavian settlement in Dublin: genetic analysis and comparison with extant breeds.

    PubMed Central

    MacHugh, D E; Troy, C S; McCormick, F; Olsaker, I; Eythórsdóttir, E; Bradley, D G

    1999-01-01

    A panel of cattle bones excavated from the 1000-year-old Viking Fishamble Street site in Dublin was assessed for the presence of surviving mitochondrial DNA (mtDNA). Eleven of these bones gave amplifiable mtDNA and a portion of the hypervariable control region was determined for each specimen. A comparative analysis was performed with control region sequences from five extant Nordic and Irish cattle breeds. The medieval population displayed similar levels of mtDNA diversity to modern European breeds. However, a number of novel mtDNA haplotypes were also detected in these bone samples. In addition, the presence of a putative ancestral sequence at high frequency in the medieval population supports an early post-domestication expansion of cattle in Europe. PMID:10091250

  1. Prediction of household and commercial BMW generation according to socio-economic and other factors for the Dublin region.

    PubMed

    Purcell, M; Magette, W L

    2009-04-01

    Both planning and design of integrated municipal solid waste management systems require accurate prediction of waste generation. This research predicted the quantity and distribution of biodegradable municipal waste (BMW) generation within a diverse 'landscape' of residential areas, as well as from a variety of commercial establishments (restaurants, hotels, hospitals, etc.) in the Dublin (Ireland) region. Socio-economic variables, housing types, and the sizes and main activities of commercial establishments were hypothesized as the key determinants contributing to the spatial variability of BMW generation. A geographical information system (GIS) 'model' of BMW generation was created using ArcMap, a component of ArcGIS 9. Statistical data including socio-economic status and household size were mapped on an electoral district basis. Historical research and data from scientific literature were used to assign BMW generation rates to residential and commercial establishments. These predictions were combined to give overall BMW estimates for the region, which can aid waste planning and policy decisions. This technique will also aid the design of future waste management strategies, leading to policy and practice alterations as a function of demographic changes and development. The household prediction technique gave a more accurate overall estimate of household waste generation than did the social class technique. Both techniques produced estimates that differed from the reported local authority data; however, given that local authority reported figures for the region are below the national average, with some of the waste generated from apartment complexes being reported as commercial waste, predictions arising from this research are believed to be closer to actual waste generation than a comparison to reported data would suggest. By changing the input data, this estimation tool can be adapted for use in other locations. Although focusing on waste in the Dublin region

  2. Crystal structure, magnetic, thermal behavior, and spectroscopic studies of two new bimetallic hydrogenselenites: [Cu2-xNix (HSeO3)2Cl2.4H2O], (x = 0.62; 0.91)

    NASA Astrophysics Data System (ADS)

    Hentech, I.; Zehani, K.; Kabadou, A.; Ben Salah, A.; Loukil, M.; Bessais, L.

    2016-08-01

    Two new iso-structural bimetallic hydrogenselenites [Cu2-xNix(HSeO3)2Cl2.4H2O] (x = 0.62; 0.91) have been synthesized from solution and characterized by single-crystal and powder X-ray diffraction. They crystallized in the orthorhombic Pnma space group with the following lattice parameters: for Cu1.09Ni0.91(HSeO3)2Cl2.4H2O: a = 9.0931 (2) Å, b = 17.7717 (4) Å, c = 7.1620 (2) Å, Z = 4, and for Cu1.38Ni0.62(HSeO3)2Cl2.4H2O: a = 9.0931 (4) Å, b = 17.7467 (7) Å, c = 7.1717 (3) Å; Z = 4. The crystal structure of this compound consists by a three-dimensional framework, but it may be described as a bi-dimensional structure consisting of layers, parallel to the (010) plane formed by two types of (Cu/Ni) octahedral and (HSeO3)- trigonal pyramids. The magnetic measurement, thermal and spectroscopic studies were performed for these compounds. The magnetic results reveal the appearance of a weak ferromagnetic behavior at low temperature (Tc = 16 K for x = 0.91 and 18.8 K for x = 0.62). The DSC analysis enabled us to locate two endothermic peaks. The first peak can be attributed to a completely dehydration of the material, in this transformation, the compounds undergo a structural phase transition which can favor a non-centrosymmetric phase at high temperature confirmed by the thermodiffractograms measurement. The second peak for these samples is due to the ferro-paraelectric phase transition which can be explained by an order- disorder transition.

  3. All-Irish Primary Schools in the Dublin Area. Report of a Sociological and Spatial Study of All-Irish-Medium Schools in the Greater Dublin Area, with Special Reference to Their Impact on Home and Social Network Use of Irish.

    ERIC Educational Resources Information Center

    O Riagain, Padraig; O Gliasain, Micheal

    A study investigated the extent to which all-Irish primary schools in the Dublin (Ireland) area: (1) provide opportunities for parents not using Irish at home to send children to an all-Irish school; (2) provide impetus for an increase in Irish use in homes of attending children; (3) increase interaction among Irish-speaking families; (4) are…

  4. Synthesis and X-ray structural investigation of K{sub 2}(H{sub 5}O{sub 2})[UO{sub 2}(C{sub 2}O{sub 4}){sub 2}(HSeO{sub 3})

    SciTech Connect

    Pushkin, D. V.; Peresypkina, E. V.; Serezhkina, L. B.; Marukhnov, A. V.; Virovets, A. V.

    2011-05-15

    The synthesis and X-ray diffraction analysis of K{sub 2}(H{sub 5}O{sub 2})[UO{sub 2}(C{sub 2}O{sub 4}){sub 2}(HSeO{sub 3})] single crystals have been performed. This compound crystallizes in the triclinic system with the unit-cell parameters a = 6.7665(4) Angstrom-Sign , b = 8.8850(4) Angstrom-Sign , c = 12.3147(7) Angstrom-Sign , {alpha} = 94.73 Degree-Sign , {beta} = 90.16 Degree-Sign , {gamma} = 92.11 Degree-Sign , sp. gr. P1-bar, Z = 2, and R = 0.019. The basic structural units are island [UO{sub 2}(C{sub 2}O{sub 4}){sub 2}(HSeO{sub 3})]{sup 3-} groups, which belong to the AB{sub 2}{sup 01}M{sup 1} crystallochemical group of uranyl complexes (A = UO{sub 2}{sup 2+}, B{sup 01} = C{sub 2}O{sub 4}{sup 2-}, and M{sub 1} = HSeO{sub 3}{sup -}). Uraniumcontaining complexes are linked through K{sup +} and H{sub 5}O{sub 2}{sup +} ions and via a system of hydrogen bonds with the participation of oxonium hydrogen atoms in this structure.

  5. Only one of the two type VI secretion systems encoded in the Salmonella enterica serotype Dublin genome is involved in colonization of the avian and murine hosts

    PubMed Central

    2014-01-01

    The type VI secretion system (T6SS) is a virulence factor for many Gram-negative bacteria. Salmonella genus harbors five phylogenetically distinct T6SS loci encoded in Salmonella Pathogenicity Islands (SPIs) SPI-6, SPI-19, SPI-20, SPI-21 and SPI-22, which are differentially distributed among serotypes. The T6SSs encoded in SPI-6 and SPI-19 contribute to pathogenesis of serotypes Typhimurium and Gallinarum in mice and chickens, respectively. Salmonella Dublin is a pathogen restricted to cattle where it causes a systemic disease. Also, it can colonize other hosts such as chickens and mice, which can act as reservoirs of this serotype. Salmonella Dublin harbors the genes for both T6SSSPI-6 and T6SSSPI-19. This study has determined the contribution of T6SSSPI-6 and T6SSSPI-19 to host-colonization by Salmonella Dublin using avian and murine models of infection. Competitive index experiments showed that, a mutant strain lacking both T6SSs (∆T6SSSPI-6/∆T6SSSPI-19) presents a strong colonization defect in cecum of chickens, similar to the defect observed for the ∆T6SSSPI-6 mutant, suggesting that this serotype requires a functional T6SSSPI-6 for efficient colonization of the avian gastrointestinal tract. Colonization of mice was also defective, although to a lesser extent than in chickens. In contrast, the T6SSSPI-19 was not necessary for colonization of either chickens or mice. Transfer of T6SSSPI-6, but not T6SSSPI-19, restored the ability of the double mutant to colonize both animal hosts. Our data indicate that Salmonella Dublin requires only the T6SSSPI-6 for efficient colonization of mice and chickens, and that the T6SSSPI-6 and T6SSSPI-19 are not functionally redundant. PMID:24405577

  6. A principal components analysis of the factors effecting personal exposure to air pollution in urban commuters in Dublin, Ireland.

    PubMed

    McNabola, Aonghus; Broderick, Brian M; Gill, Laurence W

    2009-10-01

    Principal component analysis was used to examine air pollution personal exposure data of four urban commuter transport modes for their interrelationships between pollutants and relationships with traffic and meteorological data. Air quality samples of PM2.5 and VOCs were recorded during peak traffic congestion for the car, bus, cyclist and pedestrian between January 2005 and June 2006 on a busy route in Dublin, Ireland. In total, 200 personal exposure samples were recorded each comprising 17 variables describing the personal exposure concentrations, meteorological conditions and traffic conditions. The data reduction technique, principal component analysis (PCA), was used to create weighted linear combinations of the data and these were subsequently examined for interrelationships between the many variables recorded. The results of the PCA found that personal exposure concentrations in non-motorised forms of transport were influenced to a higher degree by wind speed, whereas personal exposure concentrations in motorised forms of transport were influenced to a higher degree by traffic congestion. The findings of the investigation show that the most effective mechanisms of personal exposure reduction differ between motorised and non-motorised modes of commuter transport.

  7. Effect of a birth on the behavior of a family group of Asian elephants (Elephas maximus) at Dublin Zoo.

    PubMed

    Whilde, Jenny; Marples, Nicola

    2012-01-01

    Elephants in the wild live in herds of related females from several generations. Zoos, therefore, tend to house elephants in female groups, consisting where possible of related individuals. This type of group structure is very beneficial as it allows group members to experience events such as births in the group, and means that natural social interactions can take place between the group members. The behavior of four related female Asian elephants (Elephas maximus) at Dublin Zoo was recorded before and after the birth of a calf, to examine what effects it would have on the behavior and associations in the elephant group. The mother of the calf significantly decreased the amount of time she spent walking after the birth and the aunt of the calf showed significant decreases in both walking and standing. The mother spent the majority of her time closest to her calf after the birth, but the proportion of time she spent with each of the other individuals in the group did not change. The associations of the aunt also did not change after the birth. The older sister of the newborn calf increased the proportion of time she spent nearest to her mother after the calf was born, and reduced the time she spent close to another young elephant in the group. The new calf seems to have been successfully assimilated into the elephant group. © 2011 Wiley Periodicals, Inc.

  8. Association between acute statin therapy, survival, and improved functional outcome after ischemic stroke: the North Dublin Population Stroke Study.

    PubMed

    Ní Chróinín, Danielle; Callaly, Elizabeth L; Duggan, Joseph; Merwick, Áine; Hannon, Niamh; Sheehan, Órla; Marnane, Michael; Horgan, Gillian; Williams, Emma B; Harris, Dawn; Kyne, Lorraine; McCormack, Patricia M E; Moroney, Joan; Grant, Tim; Williams, David; Daly, Leslie; Kelly, Peter J

    2011-04-01

    Statins improve infarct volume and neurological outcome in animal stroke models. We investigated the relationship between statin therapy and ischemic stroke outcome in the North Dublin Population Stroke Study. A population-based prospective cohort study was performed using rigorous ascertainment methods. Prestroke and acute (≤72 hours) poststroke medications were recorded. Modified Rankin score and fatality were assessed at 7, 28, and 90 days and 1 year. Of 448 ischemic stroke patients, statins were prescribed before stroke onset in 30.1% (134/445) and were begun acutely (≤72 hours) in an additional 42.5% (189/445). On logistic regression analysis, adjusting for age, prestroke disability (modified Rankin scale), NIHSS score, hypertension, and aspirin, new poststroke statin therapy was independently associated with improved early and late survival (compared with statin untreated patients: OR for death, 0.12; CI, 0.03-0.54 at 7 days; OR, 0.19; CI, 0.07-0.48 at 90 days; OR, 0.26; CI, 0.12-0.55 at 1 year; P≤0.006 for all). Similar findings were observed for statin therapy before stroke onset (adjusted OR for death compared with statin-untreated-patients, 0.04; CI, 0.00-0.33; P=0.003 at 7 days; OR, 0.23; CI, 0.09-0.58; P=0.002 at 90 days; OR, 0.48; CI, 0.23-1.01; P=0.05 at 1 year). Statin therapy at stroke onset and newly begun statins were associated with improved early and late outcomes, supporting data from experimental studies. Randomized trials of statin therapy for treatment of acute stroke are needed.

  9. Stroke Associated with Atrial Fibrillation – Incidence and Early Outcomes in the North Dublin Population Stroke Study

    PubMed Central

    Hannon, Niamh; Sheehan, Orla; Kelly, Lisa; Marnane, Michael; Merwick, Aine; Moore, Alan; Kyne, Lorraine; Duggan, Joseph; Moroney, Joan; McCormack, Patricia M.E.; Daly, Leslie; Fitz-Simon, Nicola; Harris, Dawn; Horgan, Gillian; Williams, Emma B.; Furie, Karen L.; Kelly, Peter J.

    2009-01-01

    Background Prospective population-based studies are important to accurately determine the incidence and characteristics of stroke associated with atrial fibrillation (AF), while avoiding selection bias which may complicate hospital-based studies. Methods We investigated AF-associated stroke within the North Dublin Population Stroke Study, a prospective cohort study of stroke/transient ischaemic attack in 294,592 individuals, according to recommended criteria for rigorous stroke epidemiological studies. Results Of 568 stroke patients ascertained in the first year, 31.2% (177/568) were associated with AF (90.4%, i.e. 160/177 ischaemic infarcts). The crude incidence rate of all AF-associated stroke was 60/100,000 person-years (95% CI = 52–70). Prior stroke was almost twice as common in AF compared to non-AF groups (21.9 vs. 12.8%, p = 0.01). The frequency of AF progressively increased across ischaemic stroke patients stratified by increasing stroke severity (NIHSS 0–4, 29.7%; 5–9, 38.1%; 10–14, 43.8%; ≥15, 53.3%, p < 0.0001). The 90-day trajectory of recovery of AF-associated stroke was identical to that of non-AF stroke, but Rankin scores in AF stroke remained higher at 7, 28 and 90 days (p < 0.001 for all). Discussion: AF-associated stroke occurred in one third of all patients and was associated with a distinct profile of recurrent, severe and disabling stroke. Targeted strategies to increase anticoagulation rates may provide a substantial benefit to prevent severe disabling stroke at a population level. PMID:19893311

  10. Stroke associated with atrial fibrillation--incidence and early outcomes in the north Dublin population stroke study.

    PubMed

    Hannon, Niamh; Sheehan, Orla; Kelly, Lisa; Marnane, Michael; Merwick, Aine; Moore, Alan; Kyne, Lorraine; Duggan, Joseph; Moroney, Joan; McCormack, Patricia M E; Daly, Leslie; Fitz-Simon, Nicola; Harris, Dawn; Horgan, Gillian; Williams, Emma B; Furie, Karen L; Kelly, Peter J

    2010-01-01

    Prospective population-based studies are important to accurately determine the incidence and characteristics of stroke associated with atrial fibrillation (AF), while avoiding selection bias which may complicate hospital-based studies. We investigated AF-associated stroke within the North Dublin Population Stroke Study, a prospective cohort study of stroke/transient ischaemic attack in 294,592 individuals, according to recommended criteria for rigorous stroke epidemiological studies. Of 568 stroke patients ascertained in the first year, 31.2% (177/568) were associated with AF (90.4%, i.e. 160/177 ischaemic infarcts). The crude incidence rate of all AF-associated stroke was 60/100,000 person-years (95% CI = 52-70). Prior stroke was almost twice as common in AF compared to non-AF groups (21.9 vs. 12.8%, p = 0.01). The frequency of AF progressively increased across ischaemic stroke patients stratified by increasing stroke severity (NIHSS 0-4, 29.7%; 5-9, 38.1%; 10-14, 43.8%; >or=15, 53.3%, p < 0.0001). The 90-day trajectory of recovery of AF-associated stroke was identical to that of non-AF stroke, but Rankin scores in AF stroke remained higher at 7, 28 and 90 days (p < 0.001 for all). AF-associated stroke occurred in one third of all patients and was associated with a distinct profile of recurrent, severe and disabling stroke. Targeted strategies to increase anticoagulation rates may provide a substantial benefit to prevent severe disabling stroke at a population level.

  11. The occurrence of PAHs and faecal sterols in Dublin Bay and their influence on sedimentary microbial communities.

    PubMed

    Murphy, Brian T; O'Reilly, Shane S; Monteys, Xavier; Reid, Barry F; Szpak, Michal T; McCaul, Margaret V; Jordan, Sean F; Allen, Christopher C R; Kelleher, Brian P

    2016-05-15

    The source, concentration, and potential impact of sewage discharge and incomplete organic matter (OM) combustion on sedimentary microbial populations were assessed in Dublin Bay, Ireland. Polycyclic aromatic hydrocarbons (PAHs) and faecal steroids were investigated in 30 surface sediment stations in the bay. Phospholipid fatty acid (PLFA) content at each station was used to identify and quantify the broad microbial groups present and the impact of particle size, total organic carbon (%TOC), total hydrogen (%H) and total nitrogen (%N) was also considered. Faecal sterols were found to be highest in areas with historical point sources of sewage discharge. PAH distribution was more strongly associated with areas of deposition containing high %silt and %clay content, suggesting that PAHs are from diffuse sources such as rainwater run-off and atmospheric deposition. The PAHs ranged from 12 to 3072ng/g, with 10 stations exceeding the suggested effect range low (ERL) for PAHs in marine sediments. PAH isomer pair ratios and sterol ratios were used to determine the source and extent of pollution. PLFAs were not impacted by sediment type or water depth but were strongly correlated to, and influenced by PAH and sewage levels. Certain biomarkers such as 10Me16:0, i17:0 and a17:0 were closely associated with PAH polluted sediments, while 16:1ω9, 16:1ω7c, Cy17:0, 18:1ω6, i16:0 and 15:0 all have strong positive correlations with faecal sterols. Overall, the results show that sedimentary microbial communities are impacted by anthropogenic pollution. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. The passive control of air pollution exposure in Dublin, Ireland: a combined measurement and modelling case study.

    PubMed

    Gallagher, J; Gill, L W; McNabola, A

    2013-08-01

    This study investigates the potential real world application of passive control systems to reduce personal pollutant exposure in an urban street canyon in Dublin, Ireland. The implementation of parked cars and/or low boundary walls as a passive control system has been shown to minimise personal exposure to pollutants on footpaths in previous investigations. However, previous research has been limited to generic numerical modelling studies. This study combines real-time traffic data, meteorological conditions and pollution concentrations, in a real world urban street canyon before and after the implementation of a passive control system. Using a combination of field measurements and numerical modelling this study assessed the potential impact of passive controls on personal exposure to nitric oxide (NO) concentrations in the street canyon in winter conditions. A calibrated numerical model of the urban street canyon was developed, taking into account the variability in traffic and meteorological conditions. The modelling system combined the computational fluid dynamic (CFD) simulations and a semi-empirical equation, and demonstrated a good agreement with measured field data collected in the street canyon. The results indicated that lane distribution, fleet composition and vehicular turbulence all affected pollutant dispersion, in addition to the canyon geometry and local meteorological conditions. The introduction of passive controls displayed mixed results for improvements in air quality on the footpaths for different wind and traffic conditions. Parked cars demonstrated the most comprehensive passive control system with average improvements in air quality of up to 15% on the footpaths. This study highlights the potential of passive controls in a real street canyon to increase dispersion and improve air quality at street level. Copyright © 2013 Elsevier B.V. All rights reserved.

  13. Relative exposure to fine particulate matter and VOCs between transport microenvironments in Dublin: Personal exposure and uptake

    NASA Astrophysics Data System (ADS)

    McNabola, A.; Broderick, B. M.; Gill, L. W.

    To compare the relative exposure to and uptake of air pollutants between modes of commuter transport, measurements of personal exposure to PM 2.5 and traffic-related VOCs were obtained over an 18-month period. In total, 468 samples were recorded comprising journeys equally divided between the four main modes of commuter transport in Dublin, Ireland: the private car, pedestrian, public bus and cyclist. Samples were recorded along two fixed routes approaching/exiting the city centre at fixed times of the day (morning and evening peak traffic flows, 08:00-09:00 and 17:00-18:00). Samples were measured using a high flow gravimetric personal sampler for PM 2.5 and a low flow vacuum operated bag sampler for VOCs. Sampling was always carried out simultaneously between two modes of transport to ensure a direct comparison regardless of meteorological and traffic conditions. Significant differences were found between the personal exposures recorded in the four modes investigated. The car commuter was found to have the highest exposure to VOCs, while the bus commuter was found to have the highest exposure to PM 2.5. The pedestrian was consistently found to have the lowest exposure. Significant differences were also found between the two fixed routes investigated. However, as there were differences in physiological states, exposure durations and exposure levels between the four modes of transport, it was deemed necessary to estimate the total uptake of pollutants by means of a numerical human respiratory tract model. The results showed the cyclist to have the highest deposition of PM 2.5 in the lungs followed by the bus, pedestrian and car. The car passenger had the highest absorption of VOCs followed by the cyclist, pedestrian and bus. Hence, the findings of the human respiratory tract model give a significantly different impression of relative uptake of pollutants to the relative exposure concentrations found initially.

  14. Hydrogeology and Potentiometric Surface of the Dublin and Midville Aquifer Systems in Richmond County, Georgia, January 2007

    USGS Publications Warehouse

    Williams, Lester J.

    2007-01-01

    INTRODUCTION The Dublin and Midville aquifer systems are part of the Cretaceous aquifer system that underlies most of Richmond County, Georgia (Gorday, 1985; Falls and others, 1997). The Cretaceous aquifer system is the second most productive aquifer in Georgia and is a major source of water in the region. About 220 million gallons per day (Mgal/d) of water was withdrawn from the Cretaceous aquifer system during 2000 in Georgia (Fanning, 2003). The Augusta-Richmond County Water System is the largest public water supplier in the county and withdrew 13 Mgal/d of ground water during 2000; withdrawals decreased from 2001 to 2005. The towns of Hephzibah and Blythe withdrew 0.4 and 0.03 Mgal/d, respectively. Industrial ground-water withdrawals are concentrated along the Savannah River and totaled 2.89 Mgal/d. To monitor seasonal and long-term water-level fluctuations and trends in the aquifers, the U.S. Geological Survey (USGS) - in cooperation with Augusta Utilities - maintains a countywide network of about 100 water-level monitoring wells in various aquifers, including a new continuous monitoring site (well 30AA33) and two existing USGS-Georgia Environmental Protection Division network sites (wells 29AA09 and 30AA04). Data compiled during this study were used to better define the hydrogeologic units and to construct an updated potentiometric-surface map for the area, which is used to better understand ground-water movement in the Cretaceous aquifer system. In addition, the potentiometric surface and related water-level data can be used for water-resource planning and to update ground-water flow models for the region (Clarke and West, 1997; Cherry, 2006).

  15. An Efficient Multiplex PCR-Based Assay as a Novel Tool for Accurate Inter-Serovar Discrimination of Salmonella Enteritidis, S. Pullorum/Gallinarum and S. Dublin

    PubMed Central

    Xiong, Dan; Song, Li; Tao, Jing; Zheng, Huijuan; Zhou, Zihao; Geng, Shizhong; Pan, Zhiming; Jiao, Xinan

    2017-01-01

    Salmonella enterica serovars Enteritidis, Pullorum/Gallinarum, and Dublin are infectious pathogens causing serious problems for pig, chicken, and cattle production, respectively. Traditional serotyping for Salmonella is costly and labor-intensive. Here, we established a rapid multiplex PCR method to simultaneously identify three prevalent Salmonella serovars Enteritidis, Pullorum/Gallinarum, and Dublin individually for the first time. The multiplex PCR-based assay focuses on three genes tcpS, lygD, and flhB. Gene tcpS exists only in the three Salmonella serovars, and lygD exists only in S. Enteritidis, while a truncated region of flhB gene is only found in S. Pullorum/Gallinarum. The sensitivity and specificity of the multiplex PCR assay using three pairs of specific primers for these genes were evaluated. The results showed that this multiplex PCR method could accurately identify Salmonella Enteritidis, Pullorum/Gallinarum, and Dublin from eight non-Salmonella species and 27 Salmonella serovars. The least concentration of genomic DNA that could be detected was 58.5 pg/μL and the least number of cells was 100 CFU. Subsequently, this developed method was used to analyze clinical Salmonella isolates from one pig farm, one chicken farm, and one cattle farm. The results showed that blinded PCR testing of Salmonella isolates from the three farms were in concordance with the traditional serotyping tests, indicating the newly developed multiplex PCR system could be used as a novel tool to accurately distinguish the three specific Salmonella serovars individually, which is useful, especially in high-throughput screening. PMID:28360901

  16. Only one of the two type VI secretion systems encoded in the Salmonella enterica serotype Dublin genome is involved in colonization of the avian and murine hosts.

    PubMed

    Pezoa, David; Blondel, Carlos J; Silva, Cecilia A; Yang, Hee-Jeong; Andrews-Polymenis, Helene; Santiviago, Carlos A; Contreras, Inés

    2014-01-09

    The type VI secretion system (T6SS) is a virulence factor for many Gram-negative bacteria. Salmonella genus harbors five phylogenetically distinct T6SS loci encoded in Salmonella Pathogenicity Islands (SPIs) SPI-6, SPI-19, SPI-20, SPI-21 and SPI-22, which are differentially distributed among serotypes. The T6SSs encoded in SPI-6 and SPI-19 contribute to pathogenesis of serotypes Typhimurium and Gallinarum in mice and chickens, respectively. Salmonella Dublin is a pathogen restricted to cattle where it causes a systemic disease. Also, it can colonize other hosts such as chickens and mice, which can act as reservoirs of this serotype. Salmonella Dublin harbors the genes for both T6SS(SPI-6) and T6SS(SPI-19). This study has determined the contribution of T6SS(SPI-6) and T6SS(SPI-19) to host-colonization by Salmonella Dublin using avian and murine models of infection. Competitive index experiments showed that, a mutant strain lacking both T6SSs (∆T6SS(SPI-6)/∆T6SS(SPI-19)) presents a strong colonization defect in cecum of chickens, similar to the defect observed for the ∆T6SS(SPI-6) mutant, suggesting that this serotype requires a functional T6SS(SPI-6) for efficient colonization of the avian gastrointestinal tract. Colonization of mice was also defective, although to a lesser extent than in chickens. In contrast, the T6SS(SPI-19) was not necessary for colonization of either chickens or mice. Transfer of T6SS(SPI-6), but not T6SS(SPI-19), restored the ability of the double mutant to colonize both animal hosts. Our data indicate that Salmonella Dublin requires only the T6SS(SPI-6) for efficient colonization of mice and chickens, and that the T6SS(SPI-6) and T6SS(SPI-19) are not functionally redundant.

  17. G6PD (Dublin): chronic non-spherocytic haemolytic anaemia resulting from glucose-6-phosphate dehydrogenase deficiency in an Irish kindred.

    PubMed Central

    McCann, S R; Smithwick, A M; Temperley, I J; Tipton, K

    1980-01-01

    A new variant of G6PD associated with chronic non-spherocytic haemolytic anaemia (CNSHA) in an Irish male is described. This variant is unique in that it has a normal electrophoretic mobility, Michaelis constant for G6P and NADP, and a normal pH optimum, together with a marked increase in utilisation of the substrate 2 deoxy glucose-6-phosphate. It is also relatively heat stable when compared with the normal (B) variant. These characteristics distinguish this variant from previously reported variants associated with CNSHA and we have called it G6PD Dublin. PMID:7401130

  18. Mapping and converting essential Federal Geographic Data Committee (FGDC) metadata into MARC21 and Dublin Core: towards an alternative to the FGDC Clearinghouse

    USGS Publications Warehouse

    Chandler, A.; Foley, D.; Hafez, A.M.

    2000-01-01

    The purpose of this article is to raise and address a number of issues related to the conversion of Federal Geographic Data Committee metadata into MARC21 and Dublin Core. We present an analysis of 466 FGDC metadata records housed in the National Biological Information Infrastructure (NBII) node of the FGDC Clearinghouse, with special emphasis on the length of fields and the total length of records in this set. One of our contributions is a 34 element crosswalk, a proposal that takes into consideration the constraints of the MARC21 standard as implemented in OCLC's World Cat and the realities of user behavior.

  19. Pathogen translocation and histopathological lesions in an experimental model of Salmonella Dublin infection in calves receiving lactic acid bacteria and lactose supplements

    PubMed Central

    Zbrun, María V.; Soto, Lorena P.; Bertozzi, Ezequiel; Sequeira, Gabriel J.; Marti, Luis E.; Signorini, Marcelo L.; Armesto, Roberto Rodríguez; Rosmini, Marcelo R.

    2012-01-01

    The purpose of this study was to evaluate the capacity of a lactic acid bacteria (LAB) inoculum to protect calves with or without lactose supplements against Salmonella Dublin infection by evaluating histopathological lesions and pathogen translocation. Fifteen calves were divided into three groups [control group (C-G), a group inoculated with LAB (LAB-G), and a group inoculated with LAB and given lactose supplements (L-LAB-G)] with five, six, and four animals, respectively. The inoculum, composed of Lactobacillus (L.) casei DSPV 318T, L. salivarius DSPV 315T, and Pediococcus acidilactici DSPV 006T, was administered with milk replacer. The LAB-G and L-LAB-G received a daily dose of 109 CFU/kg body weight of each strain throughout the experiment. Lactose was provided to the L-LAB-G in doses of 100 g/day. Salmonella Dublin (2 × 1010 CFU) was orally administered to all animals on day 11 of the experiment. The microscopic lesion index values in target organs were 83%, 70%, and 64.3% (p < 0.05) for the C-G, LAB-G, and L-LAB-G, respectively. Administration of the probiotic inoculum was not fully effective against infection caused by Salmonella. Although probiotic treatment was unable to delay the arrival of pathogen to target organs, it was evident that the inoculum altered the response of animals against pathogen infection. PMID:23000583

  20. Syphilis serology in pregnancy: an eight-year study (2005-2012) in a large teaching maternity hospital in Dublin, Ireland.

    PubMed

    McGettrick, Padraig; Ferguson, Wendy; Jackson, Valerie; Eogan, Maeve; Lawless, Mairead; Ciprike, Vaneta; Varughese, Alan; Coulter-Smith, Sam; Lambert, John S

    2016-03-01

    All cases of positive syphilis serology detected in antenatal and peripartum screening in a large teaching maternity hospital in inner city Dublin, Ireland over an eight-year period (2005-2012 inclusive) were reviewed and included in our study. Demographic, antenatal registration, laboratory (including co-infections), partner serology, treatment and delivery data were recorded in our database. Infant follow-up, treatment and outcome data were also collected. During this period, 194 women had positive syphilis serology, of which 182 completed their pregnancies at the institution. This accounts for 0.28% of the total number of women completing their pregnancies during this time (N = 66038); 79 had no previous diagnosis of infection. There was one case of re-infection during pregnancy. Thirty-two women were co-infected with human immunodeficiency virus, hepatitis B or hepatitis C. There was one case suggestive of congenital syphilis infection. Our study is a comprehensive analysis of the diagnosis, management and clinical outcomes of women testing positive for syphilis infection in pregnancy. It reveals the relatively high prevalence of syphilis infection in the population utilising the maternity services in north inner-city Dublin. It re-enforces the importance of continued active surveillance to prevent morbidity and mortality associated with maternal syphilis infection. It also highlights the importance of strategies such as re-testing high-risk groups and definitive screening of spouse serology.

  1. Research-Teaching Linkages: Practice and Policy. Proceedings of the Third Annual Conference of the National Academy for the Integration of Research, Teaching and Learning (3rd, Dublin, Ireland, November 11-12, 2009)

    ERIC Educational Resources Information Center

    Murphy, Jennifer, Ed.; Griffin, Carrie, Ed.; Higgs, Bettie, Ed.

    2010-01-01

    The third annual conference of the National Academy for Integration of Research, Teaching and Learning (NAIRTL) was held at Trinity College Dublin on 11-12 November 2009, and was attended by over 300 delegates. The theme--"Research-Teaching Linkages: Practice and Policy"--was timely and generated some fascinating papers, workshops and…

  2. Threshold Concepts: From Personal Practice to Communities of Practice. Proceedings of the National Academy's Sixth Annual Conference and the Fourth Biennial Threshold Concepts Conference [E-publication] (Dublin, Ireland, June 27-29, 2012)

    ERIC Educational Resources Information Center

    O'Mahony, Catherine, Ed.; Buchanan, Avril, Ed.; O'Rourke, Mary, Ed.; Higgs, Bettie, Ed.

    2014-01-01

    The 6th Annual Conference of the National Academy for the Integration of Research, Teaching and Learning (NAIRTL) and the 4th Biennial Threshold Concepts Conference was held at Trinity College Dublin, Ireland, on June 27-29, 2012. The NAIRTL is a collaborative initiative between University College Cork, Cork Institute of Technology, National…

  3. MLVA for Salmonella enterica subsp. enterica Serovar Dublin: Development of a Method Suitable for Inter-Laboratory Surveillance and Application in the Context of a Raw Milk Cheese Outbreak in France in 2012

    PubMed Central

    Vignaud, Marie-Léone; Cherchame, Emeline; Marault, Muriel; Chaing, Emilie; Le Hello, Simon; Michel, Valerie; Jourdan-Da Silva, Nathalie; Lailler, Renaud; Brisabois, Anne; Cadel-Six, Sabrina

    2017-01-01

    Salmonella enterica subspecies enterica serovar Dublin (S. Dublin) figures among the most frequently isolated Salmonella strains in humans in France. This serovar may affect production and animal health mainly in cattle herds with corresponding high economic losses. Given that the current gold standard method, pulsed-field gel electrophoresis (PFGE), provides insufficient discrimination for epidemiological investigations, we propose a standard operating procedure in this study for multiple-locus variable number tandem repeat analysis (MLVA) of S. Dublin, suitable for inter-laboratory surveillance. An in silico analysis on the genome of S. Dublin strains CT_02021853 was performed to identify appropriate microsatellite regions. Of 21 VNTR loci screened, six were selected and 401 epidemiologically unrelated and related strains, isolated from humans, food and animals were analyzed to assess performance criteria such as typeability, discriminatory power and epidemiological concordance. The MLVA scheme developed was applied to an outbreak involving Saint-Nectaire cheese for which investigations were conducted in France in 2012, making it possible to discriminate between epidemiologically related strains and sporadic case strains, while PFGE assigned only a single profile. The six loci selected were sequenced on a large set of strains to determine the sequence of the repeated units and flanking regions, and their stability was evaluated in vivo through the analysis of the strains investigated from humans, food and the farm environment during the outbreak. The six VNTR selected were found to be stable and the discriminatory power of the MLVA method developed was calculated to be 0.954 compared with that for PFGE, which was only 0.625. Twenty-four reference strains were selected from the 401 examined strains in order to represent most of the allele diversity observed for each locus. This reference set can be used to harmonize MLVA results and allow data exchange between

  4. MLVA for Salmonella enterica subsp. enterica Serovar Dublin: Development of a Method Suitable for Inter-Laboratory Surveillance and Application in the Context of a Raw Milk Cheese Outbreak in France in 2012.

    PubMed

    Vignaud, Marie-Léone; Cherchame, Emeline; Marault, Muriel; Chaing, Emilie; Le Hello, Simon; Michel, Valerie; Jourdan-Da Silva, Nathalie; Lailler, Renaud; Brisabois, Anne; Cadel-Six, Sabrina

    2017-01-01

    Salmonella enterica subspecies enterica serovar Dublin (S. Dublin) figures among the most frequently isolated Salmonella strains in humans in France. This serovar may affect production and animal health mainly in cattle herds with corresponding high economic losses. Given that the current gold standard method, pulsed-field gel electrophoresis (PFGE), provides insufficient discrimination for epidemiological investigations, we propose a standard operating procedure in this study for multiple-locus variable number tandem repeat analysis (MLVA) of S. Dublin, suitable for inter-laboratory surveillance. An in silico analysis on the genome of S. Dublin strains CT_02021853 was performed to identify appropriate microsatellite regions. Of 21 VNTR loci screened, six were selected and 401 epidemiologically unrelated and related strains, isolated from humans, food and animals were analyzed to assess performance criteria such as typeability, discriminatory power and epidemiological concordance. The MLVA scheme developed was applied to an outbreak involving Saint-Nectaire cheese for which investigations were conducted in France in 2012, making it possible to discriminate between epidemiologically related strains and sporadic case strains, while PFGE assigned only a single profile. The six loci selected were sequenced on a large set of strains to determine the sequence of the repeated units and flanking regions, and their stability was evaluated in vivo through the analysis of the strains investigated from humans, food and the farm environment during the outbreak. The six VNTR selected were found to be stable and the discriminatory power of the MLVA method developed was calculated to be 0.954 compared with that for PFGE, which was only 0.625. Twenty-four reference strains were selected from the 401 examined strains in order to represent most of the allele diversity observed for each locus. This reference set can be used to harmonize MLVA results and allow data exchange between

  5. Characterising the hydrothermal circulation patterns beneath thermal springs in the limestones of the Carboniferous Dublin Basin, Ireland: a geophysical and geochemical approach.

    NASA Astrophysics Data System (ADS)

    Blake, Sarah; Henry, Tiernan; Muller, Mark R.; Jones, Alan G.; Moore, John Paul; Murray, John; Campanyà, Joan; Vozár, Jan; Walsh, John; Rath, Volker

    2016-04-01

    A hydrogeological conceptual model of the sources, circulation pathways and temporal variations of two low-enthalpy thermal springs is derived from a multi-disciplinary approach. The springs are situated in the Carboniferous limestones of the Dublin Basin, in east-central Ireland. Kilbrook spring (Co. Kildare) has the highest recorded temperatures for any thermal spring in Ireland (maximum of 25.0 °C), and St. Gorman's Well (Co. Meath) has a complex and variable temperature profile (maximum of 21.8 °C). These temperatures are elevated with respect to average Irish groundwater temperatures (9.5 - 10.5 °C), and represent a geothermal energy potential, which is currently under evaluation. A multi-disciplinary investigation based upon audio-magnetotelluric (AMT) surveys, time-lapse temperature and chemistry measurements, and hydrochemical analysis, has been undertaken with the aims of investigating the provenance of the thermal groundwater and characterising the geological structures facilitating groundwater circulation in the bedrock. The hydrochemical analysis indicates that the thermal waters flow within the limestones of the Dublin Basin, and there is evidence that Kilbrook spring receives a contribution from deep-basinal fluids. The time-lapse temperature, electrical conductivity and water level records for St. Gorman's Well indicate a strongly non-linear response to recharge inputs to the system, suggestive of fluid flow in karst conduits. The 3-D electrical resistivity models of the subsurface revealed two types of geological structure beneath the springs; (1) Carboniferous normal faults, and (2) Cenozoic strike-slip faults. These structures are dissolutionally enhanced, particularly where they intersect. The karstification of these structures, which extend to depths of at least 500 m, has provided conduits that facilitate the operation of a relatively deep hydrothermal circulation pattern (likely estimated depths between 240 and 1,000 m) within the Dublin

  6. Louis I. Dublin and the development of the observational study: the Metropolitan Life Insurance Company natural history (cohort) studies of typhoid fever and scarlet fever.

    PubMed

    Lilienfeld, David E

    2009-06-01

    During 1911-1914, using the resources of the Metropolitan Life Insurance Company, Louis I. Dublin conducted two national studies into the survival of those surviving episodes of typhoid fever or scarlet fever. He identified an elevated risk of such mortality, associated with specific causes of death, among those having had typhoid fever but not among the scarlet fever survivors. The studies were methodologically sophisticated, resembling those conducted three to four decades later. The studies appear to have been accepted by the medical and public health communities. However, the absence of modern data processing technology and the lack of financial support for such studies by other investigators precluded the further development of modern epidemiology until World War II.

  7. Health and use of health services of people who are homeless and at risk of homelessness who receive free primary health care in Dublin.

    PubMed

    Keogh, Claire; O'Brien, Kirsty K; Hoban, Anthony; O'Carroll, Austin; Fahey, Tom

    2015-02-12

    Homeless populations experience poorer physical and mental health, and more barriers to accessing adequate healthcare. This study investigates the health of this population, following the provision of a free to access primary care service for homeless people in Dublin (Safetynet). The health of this group will be compared to previous studies on homelessness conducted in Dublin prior to the establishment of this service (in 1997 and 2005). Participants were recruited through Safetynet clinics. A 133-item questionnaire was administered to determine participants' physical and mental well-being, use of health services and healthcare needs. Prescription data was extracted from participants' electronic health records. A total of 105 participants were recruited. The majority were < 45 years of age (69%), male (75%), single (52%), Irish (74%) and had children (52%). Multimorbidity was common; with 5.3 ± 2.7 (mean ± SD) physical conditions reported per person. A large proportion of participants had at some point received a formal diagnosis of a mental health condition (70%; 73/105), including depression (50%; 52/105), addiction disorder (39%), anxiety (36%; 38/105), schizophrenia (13%; 14/105) and bipolar disorder (6%; 6/105). With regards to illicit drug use, 60% (63/105) of participants reported ever using drugs, while 33% (35/105) reported being active drug users. Based on AUDIT C criteria, 53% had an alcohol problem. Compared to previous studies, participants reported more positive ratings of health (70% vs. 57% in 1997 and 46% in 2005). The proportion of participants on one or more prescription medication was higher than in previous studies (81% vs. 32% in 1997 and 49% in 2005) and there was a decrease in attendance at outpatients departments (17% vs. 27% in 2005) and a trend towards a decrease in attendance at Accident and Emergency departments (A & E) (29% vs. 37% in 2005). This vulnerable population has many physical and mental health problems. Use of

  8. First principle calculation of physical properties of barium based chalcogenides BaM4S7 (M = Ga, Al); a DFT, DFT-D and hybrid functional HSE06 study

    NASA Astrophysics Data System (ADS)

    Benghia, Ali; Dahame, Tahar; Bentria, Bachir

    2016-04-01

    The electronic structure, elastic and optical properties have been calculated for the novel nonlinear optical (NLO) crystals BaQ4S7 (Q = Ga, Al) using plane wave pseudo-potential density functional theory (DFT) method as implemented in CASTEP and ABINIT codes. In this study we used both hybrid HSE06 and DFT-D functionals with GGA approximation. These NLO compounds, which belong to the mm2 point group, are particularly interesting because of their transparency in the mid-infrared region and wide energy band gap. We present results for electronic structure, elastic tensor coefficients, refractive indices and second order nonlinear optical susceptibilities. The calculated energy band gap and frequency dependent refractive indices as well as the NLO coefficients of BaGa4S7 are in good agreement with the experimental values. With no reported theoretical or experimental energy band gap and optical properties of BaAl4S7, we present for the first time its electronic structure and above mentioned optical coefficients. This compound has higher direct band gap with 3.74 eV, better optical birefringence and second-order NLO coefficients than most NLO compounds. The second-order NLO coefficients for BaAl4S7 have been calculated as d31 = 3.15 pm/V, d31 = 2.20 pm/V, d33 = -6.31 pm/V.

  9. Balancing health care needs in a changing context: nursing highlights from the 2016 European Oncology Nursing Society Congress (EONS10), 17-18 October 2016, Dublin, Ireland.

    PubMed

    Lichosik, Danuta; Caruso, Rosario

    2017-01-01

    European cancer nurses have to face many challenges as a result of the rapidly changing economic and political context in which balancing health care needs has become strategic for healthcare delivery. Currently, cancer nurses must overcome many obstacles arising from clinical, organisational, and educational issues. Within this scenario, the European Oncology Nursing Society (EONS) shaped its tenth congress programme to boost discussion and reflections, to share experiences and research, and to see how cancer nurses try to anticipate and embrace changes. The aim of this was to promote innovative solutions and to address the many issues involved with cancer care. EONS10 was held on 17-18 October in Dublin, Ireland. The congress was attended by more than 500 delegates. The programme covered the following themes: caring for families and carers, inequalities and access to cancer care, caring for patients with haematological cancers, palliative care, communication and information exchange, community cancer care (i.e. parallel sessions), roles and responsibility for advanced nursing practice, International Psycho-Oncology Society (IPOS)-Academy workshops (i.e. workshops), cancer survivorship, clinical leadership and new roles, oncology nursing research, symptom experiences and management, palliative care (i.e. proffered papers), poster presentations, and satellite symposia. The aim of this paper is to highlight and discuss the contents of the EONS10 congress.

  10. Smoking, occupancy and staffing levels in a selection of Dublin pubs pre and post a national smoking ban, lessons for all.

    PubMed

    McCaffrey, M; Goodman, P G; Kelleher, K; Clancy, L

    2006-01-01

    On the 29th March 2004 the Irish government introduced a comprehensive workplace smoking ban to protect the health of workers. This study evaluates the impact the ban had on staffing levels, customer numbers and smoking rates in a sample of 38 public houses in Dublin. A total of 38 public houses were visited prior to the introduction of the ban, each visit lasted at least three hours, and the number of staff, customers and the number of people smoking was recorded each hour. Follow-up visits were conducted exactly one year later, on the same day of the week and at the same time of day, allowing controlling for seasonal and weekday effects. There was a decrease (8.82%) in average staff levels while customer numbers increased by 11% and there was a dramatic reduction in numbers smoking on a visit to a pub (77.8%). The hospitality industry predicted major job losses as a consequence of the introduction of the smoking ban; this work has shown that there was no significant decrease in the number of staff employed or in customer numbers. There was full compliance, with no customers smoking inside the public houses following the introduction of the ban. The ban has been good for the industry, staff, and customers.

  11. Evaluation of an O antigen enzyme-linked immunosorbent assay for screening of milk samples for Salmonella dublin infection in dairy herds.

    PubMed Central

    Hoorfar, J; Lind, P; Bitsch, V

    1995-01-01

    Levels of antibodies to the O antigens (O:1,9,12) of Salmonella dublin were tested in 1355 serum, 1143 cow milk and 160 bulk milk samples from dairy herds using an enzyme-linked immunosorbent assay (ELISA). In order to define the background reaction, milk samples from all lactating cows and serum samples from 9 animals were collected in each of 20 salmonellosis-free herds located on the island of Bornholm, where cattle salmonellosis has not been reported. Similar samples were collected from all stalled animals in 10 herds with recent (< 6 months) outbreaks of salmonellosis located in Jutland, where salmonella infection is enzootic. Using herd history of salmonellosis, herd location and clinical status of the herds as criteria, the optimal cutoff in the milk ELISA was determined as being at least 5% of the samples having optical density > 0.5, resulting in herd sensitivity of 1.0 and herd specificity of 0.95. While none of the sera in the herds from Bornholm was ELISA positive, 2 herds had a few reactors in the milk ELISA. Using the same cutoff, all but 1 bulk milk sample from 150 herds on Bornholm was ELISA-negative, and all 10 salmonellosis-positive herds from Jutland were ELISA-positive. A significant correlation was found between ELISA reactions in milk and in serum of cows (34% and 32% respectively, rs = 0.69, P < 0.001).(ABSTRACT TRUNCATED AT 250 WORDS) PMID:7648527

  12. Balancing health care needs in a changing context: nursing highlights from the 2016 European Oncology Nursing Society Congress (EONS10), 17–18 October 2016, Dublin, Ireland

    PubMed Central

    Lichosik, Danuta; Caruso, Rosario

    2017-01-01

    European cancer nurses have to face many challenges as a result of the rapidly changing economic and political context in which balancing health care needs has become strategic for healthcare delivery. Currently, cancer nurses must overcome many obstacles arising from clinical, organisational, and educational issues. Within this scenario, the European Oncology Nursing Society (EONS) shaped its tenth congress programme to boost discussion and reflections, to share experiences and research, and to see how cancer nurses try to anticipate and embrace changes. The aim of this was to promote innovative solutions and to address the many issues involved with cancer care. EONS10 was held on 17–18 October in Dublin, Ireland. The congress was attended by more than 500 delegates. The programme covered the following themes: caring for families and carers, inequalities and access to cancer care, caring for patients with haematological cancers, palliative care, communication and information exchange, community cancer care (i.e. parallel sessions), roles and responsibility for advanced nursing practice, International Psycho-Oncology Society (IPOS)-Academy workshops (i.e. workshops), cancer survivorship, clinical leadership and new roles, oncology nursing research, symptom experiences and management, palliative care (i.e. proffered papers), poster presentations, and satellite symposia. The aim of this paper is to highlight and discuss the contents of the EONS10 congress. PMID:28144284

  13. Cosmic Radiation and Aircrew Exposure: Implementation of European Requirements in Civil Aviation, Dublin, 1-3 July 1998

    NASA Astrophysics Data System (ADS)

    Talbot, Lee

    1999-03-01

    schedules with a view to reducing higher doses. Dr Bartlett summed up by saying that dose assessment will probably be done by folding roster information with estimates of route doses. The last speaker of the morning session was Dr Maria Blettner, from the International Agency for Research on Cancer, Lyon, France. She talked about epidemiological studies for individuals occupationally exposed to radiation. The speaker emphasised that the results of early studies regarding cancer mortality are equivocal; elevated cancer risks have been observed in some studies, but not in others. The low cumulative dose up to 100 mSv is associated with poor statistics. Therefore it is difficult to calculate the relative risk of exposure with a high degree of confidence. The speaker also highlighted the difficulty in obtaining a comparison population since aircrews have characteristics and lifestyles that differ from the general population. The speaker stressed the need for large studies in this field of epidemiology. Dr Blettner summarised her speech by saying that the results of a cohort of some 22 000 pilots and 47 000 crewmembers can be formed from the workers in nine different countries and that pooled analyses are expected in 2001. The next speaker was Dennis O'Sullivan, from the Dublin Institute of Advanced Studies, who gave a talk entitled `Overview and Present Status of EC Research Programme'. The objectives of the EC programme were highlighted as follows: to develop and calibrate instrumentation for use at altitude, to measure flux and energy spectra of neutrons and charged particles, to measure LET spectra and ambient dose equivalent, to estimate dose contribution by solar particle events and finally to compare results with calculations. The airlines involved in these studies were Aer Lingus, Alitalia, BA, Lufthansa and Scandinavia Airlines. Tests were carried out on several routes, on both subsonic and supersonic aircraft. A detailed set of measurements were obtained over a five

  14. Population-based study of ABCD2 score, carotid stenosis, and atrial fibrillation for early stroke prediction after transient ischemic attack: the North Dublin TIA study.

    PubMed

    Sheehan, Orla C; Kyne, Lorraine; Kelly, Lisa A; Hannon, Niamh; Marnane, Michael; Merwick, Aine; McCormack, Patricia M E; Duggan, Joseph; Moore, Alan; Moroney, Joan; Daly, Leslie; Harris, Dawn; Horgan, Gillian; Williams, Emma B; Kelly, Peter J

    2010-05-01

    Transient ischemic attack (TIA) etiologic data and the ABCD(2) score may improve early stroke risk prediction, but studies are required in population-based cohorts. We investigated the external validity of the ABCD(2) score, carotid stenosis, and atrial fibrillation for prediction of early recurrent stroke after TIA. Patients with TIA in the North Dublin city population (N=294 529) were ascertained by using overlapping hospital and community sources. The relations between individual ABCD(2) items, carotid stenosis, atrial fibrillation, and early stroke were examined. In confirmed TIA cases (n=443), carotid stenosis predicted 90-day stroke (hazard ratio=2.56; 95% CI, 1.27 to 5.15, P=0.003). Stroke risk rose with increasing grade of carotid stenosis, ranging from 5.4% (95% CI, 3.3% to 8.7%) with <50% stenosis to 17.2% (95% CI, 9.7% to 29.7%) with severe stenosis/occlusion (hazard ratio=3.3; 95% CI, 1.5 to 7.4, P=0.002). In confirmed TIA cases (n=443), the ABCD(2) score performed no better than chance for prediction of 90-day stroke (c-statistic=0.55; 95% CI, 0.45 to 0.64), largely related to the 24.2% (8/33) of patients who experienced a recurrence and had low ABCD(2) scores (0-3). However, in nonspecialist-suspected TIA cases (n=700), the predictive utility improved for stroke at 28 (c-statistic=0.61; 95% CI, 0.50 to 0.72) and 90 (c-statistic=0.61; 95% CI, 0.52 to 0.71) days. In a population-based TIA cohort, significant predictive information was provided by carotid stenosis. The ABCD(2) score had predictive utility in patients with TIA suspected by nonspecialists. Low scores occurred in several patients with stroke recurrences, suggesting that caution is needed before using the score in isolation.

  15. Digital Preservation and Deep Infrastructure; Dublin Core Metadata Initiative Progress Report and Workplan for 2002; Video Gaming, Education and Digital Learning Technologies: Relevance and Opportunities; Digital Collections of Real World Objects; The MusArt Music-Retrieval System: An Overview; eML: Taking Mississippi Libraries into the 21st Century.

    ERIC Educational Resources Information Center

    Granger, Stewart; Dekkers, Makx; Weibel, Stuart L.; Kirriemuir, John; Lensch, Hendrik P. A.; Goesele, Michael; Seidel, Hans-Peter; Birmingham, William; Pardo, Bryan; Meek, Colin; Shifrin, Jonah; Goodvin, Renee; Lippy, Brooke

    2002-01-01

    One opinion piece and five articles in this issue discuss: digital preservation infrastructure; accomplishments and changes in the Dublin Core Metadata Initiative in 2001 and plans for 2002; video gaming and how it relates to digital libraries and learning technologies; overview of a music retrieval system; and the online version of the…

  16. PhysDoc: A Distributed Network of Physics Institutions: Collecting, Indexing, and Searching High Quality Documents by Using Harvest; The Dublin Core Metadata Initiative: Mission, Current Activities, and Future Directions; Information Services for Higher Education: A New Competitive Space; Intellectual Property Conservancies.

    ERIC Educational Resources Information Center

    Severiens, Thomas; Hohlfeld, Michael; Zimmermann, Kerstin; Hilf, Eberhard R.; von Ossietzky, Carl; Weibel, Stuart L.; Koch, Traugott; Hughes, Carol Ann; Bearman, David

    2000-01-01

    Includes four articles that discuss a variety to topics, including a distributed network of physics institutions documents called PhysDocs which harvests information from the local Web-servers of professional physics institutions; the Dublin Core metadata initiative; information services for higher education in a competitive environment; and…

  17. Keeping Dublin Core Simple: Cross-Domain Discovery or Resource Description?; First Steps in an Information Commerce Economy: Digital Rights Management in the Emerging E-Book Environment; Interoperability: Digital Rights Management and the Emerging EBook Environment; Searching the Deep Web: Direct Query Engine Applications at the Department of Energy.

    ERIC Educational Resources Information Center

    Lagoze, Carl; Neylon, Eamonn; Mooney, Stephen; Warnick, Walter L.; Scott, R. L.; Spence, Karen J.; Johnson, Lorrie A.; Allen, Valerie S.; Lederman, Abe

    2001-01-01

    Includes four articles that discuss Dublin Core metadata, digital rights management and electronic books, including interoperability; and directed query engines, a type of search engine designed to access resources on the deep Web that is being used at the Department of Energy. (LRW)

  18. Keeping Dublin Core Simple: Cross-Domain Discovery or Resource Description?; First Steps in an Information Commerce Economy: Digital Rights Management in the Emerging E-Book Environment; Interoperability: Digital Rights Management and the Emerging EBook Environment; Searching the Deep Web: Direct Query Engine Applications at the Department of Energy.

    ERIC Educational Resources Information Center

    Lagoze, Carl; Neylon, Eamonn; Mooney, Stephen; Warnick, Walter L.; Scott, R. L.; Spence, Karen J.; Johnson, Lorrie A.; Allen, Valerie S.; Lederman, Abe

    2001-01-01

    Includes four articles that discuss Dublin Core metadata, digital rights management and electronic books, including interoperability; and directed query engines, a type of search engine designed to access resources on the deep Web that is being used at the Department of Energy. (LRW)

  19. The National Engineering Education Delivery System: A Digital Library for Engineering Education [and] Reference Linking in a Hybrid Library Environment (Part 1: Frameworks for Linking & Part 2:SFX, a Generic Linking Solution) [and] The State of the Dublin Core Metadata Initiative [and] Distributed Information and Computation in Scientific and Engineering Environments.

    ERIC Educational Resources Information Center

    Muramatsu, Brandon; Agogino, Alice M.; Van de Sompel, Herbert; Hochstenbach, Patrick; Weibel, Stuart; Patrikalakis, Nicholas M.; Fortier, Paul J.; Ioannidis, Yannis E.; Nikolaou, Christos N.; Robinson, Allan R.; Rossignac, Jarek R.; Vinacua, Alvar; Abrams, Stephen L.

    1999-01-01

    Describes NEEDS (National Engineering Education Delivery System), a distributed server architecture developed to enable new pedagogical models based on Internet-mediated learning environments; linking solutions for electronic library services; Dublin Core updates citing relationship to other metadata efforts; and the computational, structural and…

  20. Trends in the Evolution of the Public Web, 1998-2002; The Fedora Project: An Open-source Digital Object Repository Management System; State of the Dublin Core Metadata Initiative, April 2003; Preservation Metadata; How Many People Search the ERIC Database Each Day?

    ERIC Educational Resources Information Center

    O'Neill, Edward T.; Lavoie, Brian F.; Bennett, Rick; Staples, Thornton; Wayland, Ross; Payette, Sandra; Dekkers, Makx; Weibel, Stuart; Searle, Sam; Thompson, Dave; Rudner, Lawrence M.

    2003-01-01

    Includes five articles that examine key trends in the development of the public Web: size and growth, internationalization, and metadata usage; Flexible Extensible Digital Object and Repository Architecture (Fedora) for use in digital libraries; developments in the Dublin Core Metadata Initiative (DCMI); the National Library of New Zealand Te Puna…

  1. PhysDoc: A Distributed Network of Physics Institutions: Collecting, Indexing, and Searching High Quality Documents by Using Harvest; The Dublin Core Metadata Initiative: Mission, Current Activities, and Future Directions; Information Services for Higher Education: A New Competitive Space; Intellectual Property Conservancies.

    ERIC Educational Resources Information Center

    Severiens, Thomas; Hohlfeld, Michael; Zimmermann, Kerstin; Hilf, Eberhard R.; von Ossietzky, Carl; Weibel, Stuart L.; Koch, Traugott; Hughes, Carol Ann; Bearman, David

    2000-01-01

    Includes four articles that discuss a variety to topics, including a distributed network of physics institutions documents called PhysDocs which harvests information from the local Web-servers of professional physics institutions; the Dublin Core metadata initiative; information services for higher education in a competitive environment; and…

  2. Trends in the Evolution of the Public Web, 1998-2002; The Fedora Project: An Open-source Digital Object Repository Management System; State of the Dublin Core Metadata Initiative, April 2003; Preservation Metadata; How Many People Search the ERIC Database Each Day?

    ERIC Educational Resources Information Center

    O'Neill, Edward T.; Lavoie, Brian F.; Bennett, Rick; Staples, Thornton; Wayland, Ross; Payette, Sandra; Dekkers, Makx; Weibel, Stuart; Searle, Sam; Thompson, Dave; Rudner, Lawrence M.

    2003-01-01

    Includes five articles that examine key trends in the development of the public Web: size and growth, internationalization, and metadata usage; Flexible Extensible Digital Object and Repository Architecture (Fedora) for use in digital libraries; developments in the Dublin Core Metadata Initiative (DCMI); the National Library of New Zealand Te Puna…

  3. A strange cat in Dublin

    NASA Astrophysics Data System (ADS)

    O'Raifeartaigh, Cormac

    2012-11-01

    Not many life stories in physics involve Nazis, illicit sex, a strange cat and the genetic code. Thus, a new biography of the great Austrian physicist Erwin Schrödinger is always of interest, and with Erwin Schrödinger and the Quantum Revolution, veteran science writer John Gribbin does not disappoint.

  4. OES-IA Annex IV: Environmental Effects of Marine and Hydrokinetic Devices - Report from the Experts’ Workshop September 27th – 28th 2010 Clontarf Castle, Dublin Ireland

    SciTech Connect

    Copping, Andrea E.; O'Toole, Michael J.

    2010-12-02

    An experts' workshop was convened in Dublin Ireland September 27th – 28th 2010 in support of IEA Ocean Energy Systems Implementing Agreement Annex IV. PNNL was responsible for organizing the content of the workshop, overseeing the contractors (Irish Marine Institute) hosting the event, presenting material on Annex IV and materials applicable to the workshop intent. PNNL is also overseeing a contractor (Wave Energy Center/University of Plymouth – WEC/UP) in the collection and analysis of the Annex IV data. Fifty-eight experts from 8 countries attended the workshop by invitation, spending two days discussing the needs of Annex IV. Presentations by DOE (background on Annex IV), PNNL (process for developing Annex IV; presentation of the draft database for PNNL project, plans for incorporating Annex IV data), WEC/UP on the environmental effect matrix, and four MHK developers (two from the UK, one from Ireland and one from Sweden; each discussing their own projects and lessons learned for measuring and mitigating environmental effects, as well as interactions with consenting [permitting] processes) helped provide background. The workshop participants worked part of the time in the large group and most of the time in four smaller breakout groups. Participants engaged in the process and provided a wealth of examples of MHK environmental work, particularly in the European nations. They provided practical and actionable advice on the following: • Developing the Annex IV database, with specific uses and audiences • Strong consensus that we should collect detailed metadata on available data sets, rather than attempting to draw in copious datasets. The participants felt there would then be an opportunity to then ask for specific set of data as needed, with specific uses and ownership of the data specified. This is particularly important as many data collected, particularly in Europe but also in Canada, are proprietary; developers were not comfortable with the idea of

  5. IMACS 󈨟: Proceedings of the IMACS World Congress on Computation and Applied Mathematics (13th) Held in Dublin, Ireland on July 22-26, 1991. Volume 4. Modelling and Simulation for Electrical, Electronic and Semiconductor Devices, Computation for Management Systems, Applications of Modelling and Simulation, Environmental Systems Simulation, Software Forum, Poster Sessions

    DTIC Science & Technology

    1991-07-01

    Applied Mathematics July 22-26,1991,Trinity College, Dublin, Ireland infour volumes I ---------- -- - VOLU6-4iL- Modelling and Simulation for Electrical ...stars, electrically method allowing the study of voltage inve ter Independent and -agnetical oouplid are fed fed slotless permanent magnet machines...possible, the slotless the system behaviour is entirely described by permanent magnet machine fed by a pulse width the electric equation which is

  6. Digital Libraries and the Problem of Purpose [and] On DigiPaper and the Dissemination of Electronic Documents [and] DFAS: The Distributed Finding Aid Search System [and] Best Practices for Digital Archiving: An Information Life Cycle Approach [and] Mapping and Converting Essential Federal Geographic Data Committee (FGDC) Metadata into MARC21 and Dublin Core: Towards an Alternative to the FGDC Clearinghouse [and] Evaluating Website Modifications at the National Library of Medicine through Search Log analysis.

    ERIC Educational Resources Information Center

    Levy, David M.; Huttenlocher, Dan; Moll, Angela; Smith, MacKenzie; Hodge, Gail M.; Chandler, Adam; Foley, Dan; Hafez, Alaaeldin M.; Redalen, Aaron; Miller, Naomi

    2000-01-01

    Includes six articles focusing on the purpose of digital public libraries; encoding electronic documents through compression techniques; a distributed finding aid server; digital archiving practices in the framework of information life cycle management; converting metadata into MARC format and Dublin Core formats; and evaluating Web sites through…

  7. Digital Libraries and the Problem of Purpose [and] On DigiPaper and the Dissemination of Electronic Documents [and] DFAS: The Distributed Finding Aid Search System [and] Best Practices for Digital Archiving: An Information Life Cycle Approach [and] Mapping and Converting Essential Federal Geographic Data Committee (FGDC) Metadata into MARC21 and Dublin Core: Towards an Alternative to the FGDC Clearinghouse [and] Evaluating Website Modifications at the National Library of Medicine through Search Log analysis.

    ERIC Educational Resources Information Center

    Levy, David M.; Huttenlocher, Dan; Moll, Angela; Smith, MacKenzie; Hodge, Gail M.; Chandler, Adam; Foley, Dan; Hafez, Alaaeldin M.; Redalen, Aaron; Miller, Naomi

    2000-01-01

    Includes six articles focusing on the purpose of digital public libraries; encoding electronic documents through compression techniques; a distributed finding aid server; digital archiving practices in the framework of information life cycle management; converting metadata into MARC format and Dublin Core formats; and evaluating Web sites through…

  8. Exploring the Reactivity Trends in the E2 and SN2 Reactions of X(-) + CH3CH2Cl (X = F, Cl, Br, HO, HS, HSe, NH2 PH2, AsH2, CH3, SiH3, and GeH3).

    PubMed

    Wu, Xiao-Peng; Sun, Xiao-Ming; Wei, Xi-Guang; Ren, Yi; Wong, Ning-Bew; Li, Wai-Kee

    2009-06-09

    The reactivity order of 12 anions toward ethyl chloride has been investigated by using the G2(+) method, and the competitive E2 and SN2 reactions are discussed and compared. The reactions studied are X(-) + CH3CH2Cl → HX + CH2═CH2 + Cl(-) and X(-) + CH3CH2Cl → CH3CH2X + Cl(-), with X = F, Cl, Br, HO, HS, HSe, NH2 PH2, AsH2, CH3, SiH3, and GeH3. Our results indicate that there is no general and straightforward relationship between the overall barriers and the proton affinity (PA) of X(-); instead, discernible linear correlations only exist for the X's within the same group of the periodic table. Similar correlations are also found with the electronegativity of central atoms in X, deformation energy of the E2 transition state (TS), and the overall enthalpy of reaction. It is revealed that the electronegativity will significantly affect the barrier height, and a more electronegative X will stabilize the E2 and SN2 transition states. Multiple linear regression analysis shows that there is a reasonable linear correlation between E2 (or SN2) overall barriers and the linear combination of PA of X(-) and electronegativity of the central atom.

  9. An 11-year analysis of the prevalent uropathogens and the changing pattern of Escherichia coli antibiotic resistance in 38,530 community urinary tract infections, Dublin 1999-2009.

    PubMed

    Cullen, I M; Manecksha, R P; McCullagh, E; Ahmad, S; O'Kelly, F; Flynn, R; McDermott, T E D; Murphy, P; Grainger, R; Fennell, J P; Thornhill, J A

    2013-03-01

    Knowledge of local antimicrobial resistance patterns is essential for evidence-based empirical antibiotic prescribing, and a cutoff point of 20% has been suggested as the level of resistance at which an agent should no longer be used empirically. We sought to identify the changing incidence of causative uropathogens over an 11-year period. We also examined the trends in antibiotic resistance encountered in both the pooled urine samples and those where the causative organism was Escherichia coli. A retrospective analysis of the antimicrobial resistance within the positive community urine isolates over the 11-year period, 1999 to 2009, in a single Dublin teaching hospital was performed. In total 38,530 positive urine samples processed at our laboratory originated in the community of which 23,838 (56.7%) had E. coli as the infecting organism. The prevalence of E. coli has been increasing in recent years in community UTIs with 70.4% of UTIs in the community caused by E.coli in 2009. Ampicillin and trimethoprim were the least-active agents against E. coli with mean 11-year resistance rates of 60.8 and 31.5%, respectively. Significant trends of increasing resistance over the 11-year period were identified for trimethoprim, co-amoxyclav, cefuroxime and gentamicin. Ciprofloxacin remains a reasonable empirical antibiotic choice in this community with an 11-year resistance rate of 10.6%. Higher antibiotic resistance rates were identified in the male population and in children. Resistance rates to commonly prescribed antibiotics are increasing significantly. This data will enable evidence-based empirical prescribing which will ensure more effective treatment and lessen the emergence of resistant uropathogens in the community.

  10. Return to Education for Recovering Drug Addicts: The Soilse Project

    ERIC Educational Resources Information Center

    Barter, Eric

    2010-01-01

    This article is an account of a return to education course set up to cater to the needs of recovering heroin addicts in a Dublin rehabilitation project in the summer of 2008. It begins with a brief outline of the HSE Soilse rehabilitation and recovery programme and the rationale for seeking association with the Department of Adult and Community…

  11. HSE (CASHES) management in Niger Delta seismic operations

    SciTech Connect

    Adepoju, O.J.

    1996-12-31

    3-D seismic acquisition surveys in the Niger Delta of Nigeria, are carried out under extremely arduous field conditions due to difficult terrain, dense vegetation, semi-manual mode of operation, wildlife and volatile communities. The vegetation is a combination of evergreen tropical rain forest in the land areas and mangrove in the swamp areas. Some parts of the delta are prone to high seasonal flooding. Seismic lines are laid out by manual cutting of brush using machetes and shot holes drilled semi-manually with pumps. In order to effectively carry out the operations with due regard to the people and environment, a Community Affairs, Safety, Health, Environment and Security (CASHES) Polio and management System which ensures that a hazards are identified, assessed. controlled, with an effective loop feedback mechanism was introduced and implemented. CASHES critical activities are community relations, field security, explosives handling, water transport/journey management, river crossings. weather, shallow gas blow-out, waste management, seasonal flooding and floating-seaweed (water hyacinth)/timber logs. Environmental Impact Assessment (EIA) studies arc essential at the initial planning stages. About 41 Hazard Registers and 177 Activity Specification Sheets are developed in a typical survey. About 85% of the labor workforce are recruited from the host communities to promote cordial relations. Extensive training is carried out to raise the standards of the new recruits. The implementation of the management system is cascaded down using simplified documentation (procedures, work tasks, checklists etc.) adapted to local conditions. Integrated CASHES audits (Premob, Minor, Major. Follow up) arc conducted to check the efficiency of the system with documents getting reviewed regularly to keep the system alive and capable of handling changes. With these in place, high potential incidents are reduced/eliminated.

  12. James Joyce's "Dubliners" auf der Sekundarstufe 2 (James Joyce's "Dubliners" in Secondary Grade 2)

    ERIC Educational Resources Information Center

    Breier, Harald

    1976-01-01

    Joyce's early work offers the student an opportunity to broaden his view of and experience of the world. Some learning goals are listed, followed by methodological considerations. The experiment, done in groups, is described, as are auxiliary materials and a final test. (Text is in German.) (IFS/WGA)

  13. Looked after children in Dublin and their mental health needs.

    PubMed

    McNicholas, F; O'Connor, N; Bandyopadhyay, G; Doyle, P; O'Donovan, A; Belton, M

    2011-04-01

    Children in care in Ireland have increased by 27% in the last decade. This population is recognized to be among the most vulnerable. This study aims to describe their placement histories, service use and mental health needs. Data was obtained on 174 children (56.5% of eligible sample) with a mean age of 10.83 (SD = 5.04). 114 (65.5%) were in care for three years or more. 29 (16.7%) did not have a SW and 49 (37.7%) had no GP 50 (28.7%) were attending CAMHS. Long term care, frequent placement changes and residential setting were significantly related with poorer outcomes and increased MH contact. Given the increase in numbers in care and the overall decrease in resource allocation to health and social care, individual care planning and prioritizing of resources are essential.

  14. Development of stable isotope mixing models in ecology - Dublin

    EPA Science Inventory

    More than 40 years ago, stable isotope analysis methods used in geochemistry began to be applied to ecological studies. One common application is using mathematical mixing models to sort out the proportional contributions of various sources to a mixture. Examples include contri...

  15. Development of stable isotope mixing models in ecology - Dublin

    EPA Science Inventory

    More than 40 years ago, stable isotope analysis methods used in geochemistry began to be applied to ecological studies. One common application is using mathematical mixing models to sort out the proportional contributions of various sources to a mixture. Examples include contri...

  16. Materials Data on CeHSe (SG:194) by Materials Project

    SciTech Connect

    Kristin Persson

    2016-02-10

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  17. Modelling Public Security Operations: Evaluation of the Holistic Security Ecosystem (HSE) Proof-of-Concept

    DTIC Science & Technology

    2012-12-01

    présent travail consiste à examiner le développement d’une nouvelle capacité dans ce domaine au moyen d’une simulation informatisée ainsi que des leçons...dans les documents précédents, et culmine avec une simulation multi-agents détaillée comportant des agents de pratiques de travail de haut niveau...Deliverable 2. June 2010. [8] [UofO3] Lemyre, L, et al. “Testing the Shared Decision Making Framework in vivo.” Deliverable 3. March 2011. [9] [UofO4

  18. Interpreting HSE Contents of Planetary Basalts: The Importance of Sulfide Saturation and Under-Saturation

    NASA Technical Reports Server (NTRS)

    Righter, K.

    2000-01-01

    Highly siderophile elements provide important constraints on planetary differentiation due to their siderophile behavior. Their interpretation in terms of planetary differentiation models has so far overlooked the importance of sulfide saturation and under-saturation.

  19. Materials Data on HSeNO4 (SG:19) by Materials Project

    SciTech Connect

    Kristin Persson

    2016-07-14

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  20. Materials Data on RbHSeO4 (SG:19) by Materials Project

    SciTech Connect

    Kristin Persson

    2014-07-09

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  1. Materials Data on NaHSeO4 (SG:14) by Materials Project

    SciTech Connect

    Kristin Persson

    2016-02-04

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  2. Performance assessment of human resource by integration of HSE and ergonomics and EFQM management system.

    PubMed

    Sadegh Amalnick, Mohsen; Zarrin, Mansour

    2017-03-13

    Purpose The purpose of this paper is to present an integrated framework for performance evaluation and analysis of human resource (HR) with respect to the factors of health, safety, environment and ergonomics (HSEE) management system, and also the criteria of European federation for quality management (EFQM) as one of the well-known business excellence models. Design/methodology/approach In this study, an intelligent algorithm based on adaptive neuro-fuzzy inference system (ANFIS) along with fuzzy data envelopment analysis (FDEA) are developed and employed to assess the performance of the company. Furthermore, the impact of the factors on the company's performance as well as their strengths and weaknesses are identified by conducting a sensitivity analysis on the results. Similarly, a design of experiment is performed to prioritize the factors in the order of importance. Findings The results show that EFQM model has a far greater impact upon the company's performance than HSEE management system. According to the obtained results, it can be argued that integration of HSEE and EFQM leads to the performance improvement in the company. Practical implications In current study, the required data for executing the proposed framework are collected via valid questionnaires which are filled in by the staff of an aviation industry located in Tehran, Iran. Originality/value Managing HR performance results in improving usability, maintainability and reliability and finally in a significant reduction in the commercial aviation accident rate. Also, study of factors affecting HR performance authorities participate in developing systems in order to help operators better manage human error. This paper for the first time presents an intelligent framework based on ANFIS, FDEA and statistical tests for HR performance assessment and analysis with the ability of handling uncertainty and vagueness existing in real world environment.

  3. Materials Data on LiCd2HSe2O7 (SG:14) by Materials Project

    SciTech Connect

    Kristin Persson

    2016-02-04

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  4. Materials Data on RbHSeO4 (SG:1) by Materials Project

    SciTech Connect

    Kristin Persson

    2014-07-09

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  5. Ab Initio Study of Aluminium Impurity and Interstitial-Substitutional Complexes in Ge Using a Hybrid Functional (HSE)

    NASA Astrophysics Data System (ADS)

    Igumbor, E.; Mapasha, R. E.; Meyer, W. E.

    2017-07-01

    The results of an ab initio modelling of aluminium substitutional impurity ({\\hbox {Al}}_Ge), aluminium interstitial in Ge [{\\hbox {I}}_Al for the tetrahedral (T) and hexagonal (H) configurations] and aluminium interstitial-substitutional pairs in Ge ({\\hbox {I}}_Al{\\hbox {Al}}_Ge) are presented. For all calculations, the hybrid functional of Heyd, Scuseria, and Ernzerhof in the framework of density functional theory was used. Defects formation energies, charge state transition levels and minimum energy configurations of the {\\hbox {Al}}_Ge, {\\hbox {I}}_Al and {\\hbox {I}}_Al{\\hbox {Al}}_Ge were obtained for -2, -1, 0, +1 and +2 charge states. The calculated formation energy shows that for the neutral charge state, the {\\hbox {I}}_Al is energetically more favourable in the T than the H configuration. The {\\hbox {I}}_Al{\\hbox {Al}}_Ge forms with formation energies of -2.37 eV and -2.32 eV, when the interstitial atom is at the T and H sites, respectively. The {\\hbox {I}}_Al{\\hbox {Al}}_Ge is energetically more favourable when the interstitial atom is at the T site with a binding energy of 0.8 eV. The {\\hbox {I}}_Al in the T configuration, induced a deep donor (+2/+1) level at EV+0.23 eV and the {\\hbox {Al}}_Ge induced a single acceptor level (0/-1) at EV+0.14 eV in the band gap of Ge. The {\\hbox {I}}_Al{\\hbox {Al}}_Ge induced double-donor levels are at E_V+0.06 and E_V+0.12 eV, when the interstitial atom is at the T and H sites, respectively. The {\\hbox {I}}_Al and {\\hbox {I}}_Al{\\hbox {Al}}_Ge exhibit properties of charge state-controlled metastability.

  6. Re-Os Systematics and HSE Distribution in Tieschitz (H3.6): Two Isochrons for One Meteorite

    NASA Technical Reports Server (NTRS)

    Smoliar, M. I.; Horan, M. F.; Alexander, C. M. OD.; Walker, R. J.

    2004-01-01

    Tieschitz is an ordinary chondrite that displays some unique features. So called "white matrix" and "bleached chondrules" are found in only few chondrites, while in Tieschitz they are significant components. These phases have been the object of numerous studies, and are generally considered to be formed by secondary alteration or even redeposition. A Sm-Nd study of selected chondrules from Tieschitz yielded a surprisingly young apparent age of 2.0 Ga, which most likely reflects the time of the alteration process. This makes Tieschitz very interesting with respect to providing a record of a young alteration event.

  7. The Fractionation of Highly Siderophile Elements (HSE) in Impact Melts and the Determination of the Meteoritic Components

    NASA Astrophysics Data System (ADS)

    Schmidt, G.; Palme, H.; Kratz, K. L.

    1995-09-01

    Lunar highland rocks contain an excess of siderophile elements, which has been attributed to meteoritic influx after the formation of the lunar crust [1-4]. Siderophile element enrichment has subsequently become a standard method for the identification of terrestrial impact craters. Janssens et al. [5], Grieve [6] and Palme et al. [7] have shown the dominant role of impact melt as the main carrier of meteoritic material at large terrestrial impact craters. This has been demonstrated at Clearwater East [8], Lappajarvi [9-11], Saaksjarvi [12], Brent [6] and Rochechouart [5]. The amount of projectile material incorporated in impact melt sheets is generally low (<1%). The highest recorded is 8% at East Clearwater, where the siderophiles are carried in a sulphide phase. In other cases, searches for siderophile anomalies at some impact structure have been largely unsuccessful. Melt bearing mixed breccias (suevitic melt) and fall-back sediments have been found to be free of meteoritic components in Brent, Lappajarvi and Ries samples [6,9,12-14]. However, from approximately 130 craters which are currently known on Earth only four clearly identified chondrites have been found as projectiles of large craters [15,16]. In this study we analyzed twenty-two impact melt samples (10 g) from Saaksjarvi (Finland), Mien and Dellen (Sweden) impact craters for Os, Re, Ir, Ru, Rh, Pd and Au by a slightly modified version of the fire assay neutron activation method using nickel sulphide as the collector [13,14]. All samples were obtained from the collection of the University of Munster. Only fresh, nearly fragment-free, fine grained samples without any sign of alteration were selected for chemical studies. All samples have been described previously [17]. The INAA procedure involved two irradiations: a short irradiation for Rh and a long irradiation for the other elements. Impact melts from Saaksjarvi are highly enriched in PGEs. The flat siderophile pattern suggests that the meteoritic component (PGE/CI = 3x10^-3 to 9x10^-3 relative to CI) in the Saaksjarvi impact melt is relatively unfractionated. Stony-iron meteorites (pallasites) as proposed earlier [7] can therefore be excluded as possible contaminants because Pd and Ir are highly fractionated in pallasites [18]. Impact melts from Mien and Dellen are moderately enriched in PGE. The concentrations are similar (PGE/CI = 3x10^-4 to 1x10^-3 relative to CI). The flat siderophile pattern of the Mien and Dellen impact samples are compatible with carbonaceous chondrite type of material, but a clear geochemical association of any of the known meteorite types is not possible because of the low signal-to-background ratio for Rh, Ru, Pd, and Au. Samples from all impact craters have low Os/PGE ratios (Os/Ir(sub)melt =0.24) compared to chondritic ratios (Os/Ir(sub)CI=1.06). It seems that the oxygen fugacity at the time of impact melting, vaporization and crystallization of the melt body may play the dominant role in the fractionation of Os and PGEs. If Os have been partially lost by volatilization of OsO4 under oxidizing conditions, then Ir is the only element to confirm meteoritic enrichments down to a level of 2x10^-4 CI chondrite. None of the other elements determined are sufficiently sensitive indicators to confirm small meteoritic enrichments, equivalent to <10^-3 CI chondrite, because of low CI/Earth crust-ratios. Acknowledgements. This work was supported by DFG. References: [1] Wasson J. T. et al. (1975) Moon, 13, 121-141. [2] Gros J. et al. (1976) Proc. LSC 7th, 2403-2425. [3] Hertogen J. et al. (1977) Proc. LSC 8th, 17-45. [4] Palme H. (1980) Proc. LPSC 11th, 481-506. [5] Janssens M.-J. et al. (1977) JGR, 82, 750-758. [6] Grieve R. A. F. (1978) Proc. LPSC 9th, 2579-2608. [7] Palme H. et al. (1980) LPSC XI, 848-850. [8] Palme H. et al. (1978) GCA, 42, 313-323. [9] Reimold W. U. and Stoffler D. (1980) Meteoritics, 14, 526-528. [10] Reimold W. U. (1980) Ph. D. thesis, Univ. of Munster, 172 pp. [11] Gobel E. et al. (1980) Z. Naturforsch., 35a, 197-203. [12] Morgan J. W. et al. (1979) GCA, 4

  8. Patient and hospital delays in acute ischaemic stroke in a Dublin teaching hospital.

    PubMed

    Pittock, S J; Meldrum, D; Hardiman, O; Deane, C; Dunne, P; Hussey, A; Gorman, M; Moroney, J T

    2003-06-01

    A limiting factor for thrombolysis in ischaemic stroke is delayed presentation to hospital. Prolonged A&E stay and delayed rehabilitation affects care. We evaluated the delay in presentation, A&E stay and rehabilitation delivery in 117 consecutive stroke patients. The mean presentation delay was 16.0 +/- 23.7 hours. A prior history of TIA or stroke, a reduced Glascow Coma Scale and larger strokes were associated with shorter delays to presentation. Longer delays occurred in patients living alone. The mean time spent in A&E was 11 hours, those with larger strokes spent shorter time. There were significant delays in referral to, and assessment by certain rehabilitation disciplines. Delayed presentation in stroke is a barrier to thrombolysis. Increasing public awareness may reduce this delay. In addition, prolonged A&E stay and delayed rehabilitation may adversely affect management, outcome and duration of hospital stay. Further study is required to investigate the reasons and possible solutions for such deficiencies.

  9. Phenotypic and genotypic characterization of Salmonella enterica serovar Dublin isolates from cattle and humans

    USDA-ARS?s Scientific Manuscript database

    Introduction: Antimicrobial resistance (AR), particularly multi-drug resistance (MDR), is of global concern. Salmonella causes approximately 93.8 million human infections worldwide/year including 1.2 million cases in the US. An increase in both AR and MDR among some serotypes has been observed. Sa...

  10. Coolmine Therapeutic Community, Dublin: a 40-year history of Ireland's first voluntary drug treatment service.

    PubMed

    Butler, Shane

    2016-02-01

    To document the evolution over 40 years (from 1973 to 2013) of Coolmine Therapeutic Community (Ireland's first voluntary drug treatment service) against a background of broader drug policy developments in the Republic of Ireland and elsewhere during this period. Data were gathered by means of archival research within Coolmine, complemented by semi-structured interviews with former clients, current and former Coolmine management and staff, and representatives of outsider stakeholder interests. Coolmines's history has three phases: (1) an early and uncontentious phase, in which external authorities provided financial support for Coolmine without questioning its work practices or outcomes; (2) a middle, controversial phase, in which Coolmine struggled for survival in an external policy environment now dominated by harm reduction strategies; and (3) a final phase in which, through the use of conventional corporate governance, Coolmine management sought to repair its damaged reputation by introducing evidence-based clinical practices. Coolmine Therapeutic Community was established when drug treatment services in Ireland were in their infancy, and its changing fortunes over subsequent decades reflected changing perceptions of what constitutes appropriate addiction treatment-and in particular the role to be played by former addicts within addiction treatment systems-as well as changing perceptions of funding relationships between statutory authorities and voluntary providers of health and social services. © 2015 Society for the Study of Addiction.

  11. Student Experiences of Assessment in Two Problem-Based Dental Curricula: Adelaide and Dublin

    ERIC Educational Resources Information Center

    Winning, Tracey; Lim, Elaine; Townsend, Grant

    2005-01-01

    Dental students in third (n=35) and fifth years (n=50) at Adelaide and Trinity College Dental Schools were surveyed about their experiences of assessment and their perceptions of the importance of particular aspects of assessment. Students reported on their assessment experience within their programmes by describing a critical assessment incident…

  12. Supporting Parental Involvement in Children's Early Learning: Lessons from Community Childcare Centres in Dublin's Docklands

    ERIC Educational Resources Information Center

    Share, Michelle; Kerrins, Liz

    2013-01-01

    Recently in Ireland attention has been placed on the importance of parental involvement in early childhood care and education settings as seen in the Síolta Quality Standards and Aistear Curriculum Framework. Yet there is little Irish empirical evidence on parental involvement in childcare settings; on the involvement models being used, or on the…

  13. Devising and Implementing a Suitable Graduate Education Platform for Dublin's Institute of Technology (DIT)

    ERIC Educational Resources Information Center

    Carton, Janet; Jerrams, Steve

    2008-01-01

    Graduate education platforms have received general acclaim as key components in the future structural development of third-level and fourth-level education in Europe. In Ireland the Higher Education Authority (HEA) has endorsed the restructuring of postgraduate education to incorporate the training of research students in key generic and…

  14. Continuing Education Master Plan for New River Community College, Dublin, Virginia 24084.

    ERIC Educational Resources Information Center

    Kinzer, Allen O.

    An adult education master plan for Virginia's New River Community College is presented. The plan is divided into the following areas: (1) college philosophy and objectives; (2) description of the service region (population, educational and economic data and employment characteristics); (3) what the college is doing, should be doing, and is…

  15. Constructing a Community Response Grid (CRG): The Dublin, Ohio Case Study

    ERIC Educational Resources Information Center

    Freund, John F., III.

    2012-01-01

    During an emergency, information availability is critical to preserving life and minimizing damages. During the emergency response, however, information may not be available to those who need it. A community response grid (CRG) can help ameliorate this lack of availability by allowing people to document and distribute emergency information to…

  16. Media Technologies and Language Learning. Proceedings of an IRAAL Seminar (Dublin, Ireland, November 25, 1989).

    ERIC Educational Resources Information Center

    Little, David, Ed.; O Meadhra, Bebhinn, Ed.

    A seminar sponsored by the Irish Association for Applied Linguistics on the role of media and media technologies in second and foreign language learning is reported. The organization of this report reflects the program of the seminar. Four plenary papers established some broad applied linguistic perspectives and presented an overview of recent…

  17. Constructing a Community Response Grid (CRG): The Dublin, Ohio Case Study

    ERIC Educational Resources Information Center

    Freund, John F., III.

    2012-01-01

    During an emergency, information availability is critical to preserving life and minimizing damages. During the emergency response, however, information may not be available to those who need it. A community response grid (CRG) can help ameliorate this lack of availability by allowing people to document and distribute emergency information to…

  18. Supporting Parental Involvement in Children's Early Learning: Lessons from Community Childcare Centres in Dublin's Docklands

    ERIC Educational Resources Information Center

    Share, Michelle; Kerrins, Liz

    2013-01-01

    Recently in Ireland attention has been placed on the importance of parental involvement in early childhood care and education settings as seen in the Síolta Quality Standards and Aistear Curriculum Framework. Yet there is little Irish empirical evidence on parental involvement in childcare settings; on the involvement models being used, or on the…

  19. Devising and Implementing a Suitable Graduate Education Platform for Dublin's Institute of Technology (DIT)

    ERIC Educational Resources Information Center

    Carton, Janet; Jerrams, Steve

    2008-01-01

    Graduate education platforms have received general acclaim as key components in the future structural development of third-level and fourth-level education in Europe. In Ireland the Higher Education Authority (HEA) has endorsed the restructuring of postgraduate education to incorporate the training of research students in key generic and…

  20. Constructing Web Subject Gateways Using Dublin Core, the Resource Description Framework and Topic Maps

    ERIC Educational Resources Information Center

    Tramullas, Jesus; Garrido, Piedad

    2006-01-01

    Introduction: Specialised subject gateways have become an essential tool for locating and accessing digital information resources, with the added value of organisation and previous evaluation catering for the needs of the varying communities using these. Within the framework of a research project on the subject, a software tool has been developed…

  1. Herpes simplex virus reactivation after subtotal hemispherectomy in a pediatric patient.

    PubMed

    Gong, Tracie; Bingaman, William; Danziger-Isakov, Lara; Tuxhorn, Ingrid; Goldfarb, Johanna

    2010-12-01

    We report herpes simplex encephalitis (HSE) in a toddler after a subtotal hemispherectomy for seizures related to HSE 16 months earlier. Herpes simplex virus reactivation in the cerebrospinal fluid shortly after treatment of HSE has been described, but is extremely rare in other situations. HSE reactivation is a potential complication of epilepsy surgery after HSE in children.

  2. Emergency Preparedness technology support to the Health and Safety Executive (HSE), Nuclear Installations Inspectorate (NII) of the United Kingdom. Appendix A

    SciTech Connect

    O`Kula, K.R.

    1994-03-01

    The Nuclear Installations Inspectorate (NII) of the United Kingdom (UK) suggested the use of an accident progression logic model method developed by Westinghouse Savannah River Company (WSRC) and Science Applications International Corporation (SAIC) for K Reactor to predict the magnitude and timing of radioactivity releases (the source term) based on an advanced logic model methodology. Predicted releases are output from the personal computer-based model in a level-of-confidence format. Additional technical discussions eventually led to a request from the NII to develop a proposal for assembling a similar technology to predict source terms for the UK`s advanced gas-cooled reactor (AGR) type. To respond to this request, WSRC is submitting a proposal to provide contractual assistance as specified in the Scope of Work. The work will produce, document, and transfer technology associated with a Decision-Oriented Source Term Estimator for Emergency Preparedness (DOSE-EP) for the NII to apply to AGRs in the United Kingdom. This document, Appendix A is a part of this proposal.

  3. EFFECT OF AIR-POLLUTION CONTROL ON DEATH RATES IN DUBLIN, IRELAND: AN INTERVENTION STUDY. (R827353C006)

    EPA Science Inventory

    Background Particulate air pollution episodes have been associated with increased daily death. However, there is little direct evidence that diminished particulate air pollution concentrations would lead to reductions in death rates. We assessed the effect of ...

  4. Nuclear Magnetic Resonance of Polymeric Materials: Proceedings of the Autumn Meeting of the British Radiofrequency Group Held at Dublin (Ireland).

    DTIC Science & Technology

    1983-01-01

    the Fokker - Planck equation for the case of particles with inertia and soft forces which has the form: - -F 1) ic Nr . 7) (V)being the velocity dependent...more difficult to derive these models directly from sensible equations of motion, but progress in this direction is reported in the paper. S...the worse since the first has non stochastic equations , and the crystal is at least quite explicit and there is a well defined band theory. The liquid

  5. Language across Cultures. Proceedings of a Symposium (St. Patrick's College, Dublin, Ireland, July 8-9, 1983).

    ERIC Educational Resources Information Center

    Mathuna, Liam Mac; Singleton, David

    Papers presented at the symposium on the relationship between language and culture include, in addition to an opening adress: "Sociosemiotics Across Cultures" (Wolfgang Kuhlwein); "Translation Across Languages or Across Cultures?" (Albrecht Neubert); "Grammatical Categories Across Cultures" (Olga Tomic); "On…

  6. EFFECT OF AIR-POLLUTION CONTROL ON DEATH RATES IN DUBLIN, IRELAND: AN INTERVENTION STUDY. (R827353C006)

    EPA Science Inventory

    Background Particulate air pollution episodes have been associated with increased daily death. However, there is little direct evidence that diminished particulate air pollution concentrations would lead to reductions in death rates. We assessed the effect of ...

  7. What Do Young People Need When They Leave Care? Views of Care-Leavers and Aftercare Workers in North Dublin

    ERIC Educational Resources Information Center

    Daly, Fiona

    2012-01-01

    EPIC is an independent voluntary organisation in the Republic of Ireland that advocates for the rights of children in care and young people who have care experience. One aspect of EPIC's work is the Aftercare Advocacy and Support Service, which provides confidential advice and support to young people who are preparing to leave care, those in…

  8. The First Year Experience. Conference Proceedings of the International Conference (7th, Dublin, Ireland, July 18-22, 1994).

    ERIC Educational Resources Information Center

    South Carolina Univ., Columbia. Center for the Study of the Freshman Year Experience.

    These proceedings contain 68 author-prepared abstracts of presentations given at the Seventh International Conference on the First-Year Experience, a 5-day conference that focused on the foundations for improving the undergraduate experience. The majority of the one- to two-page abstracts report on specific programs undertaken by colleges or…

  9. Reclaiming respectability? The class-cultural dynamics of crime, community and governance in inner-city Dublin.

    PubMed

    Ilan, Jonathan

    2011-01-01

    This paper critically examines developments in Irish urban governance through an ethnographic account of one community's historical memory and contemporary structure. During an era of rapid economic growth, the Irish state has courted previously excluded communities, offering them greater "inclusion" as "partners" in responding to urban decay and crime. The micro-governance structures this creates, however, become sites of contest between competing community factions and class-cultural imperatives. Tensions emerge between aspirational community leaders championing the aesthetics (if not the values) of "respectability" and residual residents who are presented as "rough". The paper demonstrates that nuances of class-cultural identity dictate the character of partnership governance at the community level with particular implications for local regeneration and crime control agendas.

  10. Metabolic Field (Schrodinger); an explanatory platform for biology: Based on lecture at Trinity College, Dublin, Ireland, July 18, 2012.

    PubMed

    Bortz, Walter M

    2015-12-01

    Metabolism represents the nexus of fundamental physical forces, which while present in all structure and function require new explanatory emergent principles, which, so far, cannot be predicted or derived solely from description of chemistry and physics. Metabolism is essentially concerned with the transduction of energy flows with respect to time, space, and matter. Language models and metaphors contribute to construction of scientific explanation within biology. The concept of a metabolic field yields a deeper, broader, more quantitative integrated theoretical framework leading to novel predictive models of systems biology. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. Can we differentiate between herpes simplex encephalitis and Japanese encephalitis?

    PubMed

    Kalita, Jayantee; Misra, Usha Kant; Mani, Vinita Elizabeth; Bhoi, Sanjeev Kumar

    2016-07-15

    Herpes simplex encephalitis (HSE) occurs without regional and seasonal predilections. HSE is important to differentiate from arboviral encephalitis in endemic areas because of therapeutic potential of HSE. This study evaluates clinical features, MRI and laboratory findings which may help in differentiating HSE from Japanese encephalitis (JE). Confirmed patients with JE and HSE in last 10years were included. The presenting clinical symptoms including demographic information, seizure, behavioral abnormality, focal weakness and movement disorders were noted. Cranial MRI was done and location and nature of signal alteration were noted. Electroencephalography (EEG), cerebrospinal fluid (CSF), blood counts and serum chemistry were done. Outcome was measured by modified Rankin Scale (mRS). Death, functional outcome and neurological sequelae were noted at 3, 6 and 12months follow up, and compared between HSE and JE. Outcome was categorized as poor (mRS;>2) and good (mRS≤2). 97 patients with JE and 40 HSE were included. JE patients were younger than HSE and occurred in post monsoon period whereas HSE occurred throughout the year. Seizure (86% vs 40%) and behavioral abnormality (48% vs 10%) were commoner in HSE; whereas movement disorders (76% vs 0%) and focal reflex loss (42% vs 10%) were commoner in JE. CSF findings and laboratory parameters were similar in both the groups. Thalamic involvement in JE and temporal involvement in HSE were specific markers of respective encephalitis. Delta slowing on EEG was more frequent in JE than HSE. 20% JE and 30% HSE died in the hospital, and at 1year follow up JE patients showed better outcome compared to HSE (48% vs 24%). Memory loss (72% vs 22%) was the predominant sequelae in HSE. Seizure and behavioral abnormality are common features in HSE whereas focal reflex loss is commoner in JE. In a patient with acute encephalitis, thalamic lesion suggests JE and temporal lobe involvement HSE. Long term outcome in JE is better compared to

  12. The International Cytokine Conference (11th) Held in Dublin (Ireland) on September 20-24 2003 (European Cytokine Network, Volume 14, Number 3, September 2003)

    DTIC Science & Technology

    2003-09-01

    remission has depended upon both initial thrombopoietin ( TPO ) and FLT-3 ligand (FL). Both lytic and latent condition of cellular immunity and dynamic...protein responses (APR), are susceptible ously shown that pretreatment of mice with CpG-motifs of bacterial for acquiring pneumonia. In mice, turpentine...level. Pretreatment of A549 cells with IFN-a (100 IU/ml, 24 h) lead to a dramatic increase in influenza A virus-induced IFN, IL-28, IL-29 and chemokine

  13. Flexible Learning: Proceedings of the National Academy for Integration of Research, Teaching and Learning Annual Conference (4th, Dublin, Ireland, October 6-7, 2010)

    ERIC Educational Resources Information Center

    National Academy for Integration of Research, Teaching and Learning (NJ1), 2011

    2011-01-01

    This volume presents 64 abstracts of keynote and parallel paper presentations of the Irish National Academy for Integration of Research, Teaching and Learning's (NAIRTL) conference on the theme of flexible learning. The Flexible Learning conference was a joint initiative by NAIRTL and the Learning Innovation Network. The keynote presentations can…

  14. Diagnostic usefulness of the ABCD2 score to distinguish transient ischemic attack and minor ischemic stroke from noncerebrovascular events: the North Dublin TIA Study.

    PubMed

    Sheehan, Orla C; Merwick, Aine; Kelly, Lisa A; Hannon, Niamh; Marnane, Michael; Kyne, Lorraine; McCormack, Patricia M E; Duggan, Joseph; Moore, Alan; Moroney, Joan; Daly, Leslie; Harris, Dawn; Horgan, Gillian; Kelly, Peter J

    2009-11-01

    Transient ischemic attack (TIA) diagnosis is frequently difficult in clinical practice. Noncerebrovascular symptoms are often misclassified as TIA by nonspecialist physicians. Clinical prediction rules such as ABCD(2) improve the identification of patients with TIA at high risk of early stroke. We hypothesized that the ABCD(2) score may partly improve risk stratification due to improved discrimination of true TIA and minor ischemic stroke (MIS) from noncerebrovascular events. Consecutive patients with TIA were identified within a prospective population-based cohort study of stroke and TIA. The cohort was expanded by inclusion of patients with MIS and noncerebrovascular events referred to a daily TIA clinic serving the population. Diagnosis was assigned by a trained stroke physician independent of ABCD(2) score. Five hundred ninety-four patients were included (292 [49.2%] TIA, 45 [7.6%] MIS, and 257 [43.3%] noncerebrovascular). The mean ABCD(2) score showed a graded increase across diagnostic groups (MIS mean 4.8 [SD 1.4] versus TIA mean 3.9 [SD 1.5] versus noncerebrovascular mean 2.9 [SD 1.5]; P<0.00001). The ABCD(2) score discriminated well between noncerebrovascular and cerebrovascular events-TIA (c-statistic 0.68; 95% CI, 0.64 to 0.72), any vascular event (TIA+MIS; c-statistic 0.7; 95% CI, 0.66 to 0.74), and MIS (c-statistic 0.81; 95% CI, 0.75 to 0.87)-from noncerebrovascular events. Of ABCD(2) items, unilateral weakness (OR, 4.5; 95% CI, 3.1 to 6.6) and speech disturbance (OR, 2.5; 95% CI, 1.6, 4.1) were most likely overrepresented in TIA compared with noncerebrovascular groups. The ABCD(2) score had significant diagnostic usefulness for discrimination of true TIA and MIS from noncerebrovascular events, which may contribute to its predictive usefulness.

  15. The sensitivity and specificity of the RSID-saliva kit for the detection of human salivary amylase in the Forensic Science Laboratory, Dublin, Ireland.

    PubMed

    Casey, David G; Price, Judy

    2010-01-30

    We demonstrate here that the RSID-saliva test can be used as a test for human salivary alpha-amylase on samples routinely examined in forensic casework. We show that the RSID-saliva test detects salivary alpha-amylase at lower concentrations than the Phadebas Quantitative test, that the RSID-saliva test does not cross-react with forensically important human fluids and that the RSID-saliva test can be successfully integrated into the whole swab semen extraction method. 2009 Elsevier Ireland Ltd. All rights reserved.

  16. Medicine in the age of " Ulysses ": James Joyce's portrait of life, medicine, and disease on a Dublin day a century ago.

    PubMed

    Shanahan, Fergus; Quigley, Eamonn M

    2006-01-01

    Over time, contemporary writing becomes part of the historical record. In medicine, it is an important learning tool, particularly for understanding the experience and context of disease and illness. Although a century has elapsed since the fictional events on a single day described in James Joyce's Ulysses, the work is still fresh with references and allusions to doctors, illnesses, and the human experience. Ulysses provides perspective on medical and social history and offers a biting commentary of continuing relevance to the doctor-patient relationship.

  17. New Approaches in the Language Classroom: Coping with Change. Proceedings of the National Modern Languages Convention (2nd, Dublin, Ireland, January 31-February 1, 1986).

    ERIC Educational Resources Information Center

    Little, David, Ed.; And Others

    These conference proceedings include: (1) opening speeches; (2) "Must Language Teaching Be Communicative?" (Christopher Brumfit); (3) "Recipes for Tired Teachers" (Mario Rinvolucri); (4) "Facing the Challenge of New Technologies: Interactive Video and the AUTOTUTOR Project" (David Little, Eugene Davis); (5) a panel discussion of questions…

  18. Perspectives on the English Language in Ireland. Proceedings of the Symposium on Hiberno-English (1st, Dublin, Ireland, September 16-17, 1985).

    ERIC Educational Resources Information Center

    Harris, John, Ed.; And Others

    This collection of symposium papers on varieties of the English language used in Ireland includes: "The Role of Irish English in the Formation of Colonial Englishes," by P. Trudgill; "Anglo-Irish Verse in Translation from Irish," by P. L. Henry; "The Methodology of Urban Language Studies," by J. Milroy;…

  19. Command Language and Screen Displays for Public Online Systems. Report of a Meeting Sponsored by the Council on Library Resources (Dublin, Ohio, March 29-30, 1984).

    ERIC Educational Resources Information Center

    Peters, Paul Evan, Ed.

    The Bibliographic Service Development Program of the Council on Library Resources convened a meeting of experts in March 1984 to consider the advisability of applying standards in the development and operation of online public access catalog systems in libraries. Following presentations from three invited participants, working groups were formed…

  20. Prevalence of frailty among community dwelling older adults in receipt of low level home support: a cross-sectional analysis of the North Dublin Cohort.

    PubMed

    Kelly, Sara; O'Brien, Irene; Smuts, Karla; O'Sullivan, Maria; Warters, Austin

    2017-06-07

    There is increasing demand for formal government funded home help services to support community-dwelling older people in Ireland, yet limited information exists on the health profiles of this group, especially regarding frailty. Our aim was to profile a large cohort of adults in receipt of low level home help and to determine the prevalence of frailty. A total 1312 older adults, (≥ 65 years) in receipt of low level home help (< 5 h per week) were reviewed by community nurses and frailty was assessed using the Clinical Frailty Scale (CFS) in this cross-sectional study. Characteristics of the group were compared between males and females and prevalence of frailty was reported according to gender and principal care. Associations between frailty and a number of variables were explored using bivariate and regression analysis. The cohort of low level home-help users was a mean age of 82.1 (SD 7.3) years, predominantly female (70.6%) and over half (69.2%) lived alone. The prevalence of frailty in this population was 41.5%, with subjects primarily considered mildly (23.2%) or moderately frail (14.5%) by the CFS. A further 38.4% were classed as vulnerable. The degree of frailty did not differ significantly across the younger categories aged 65-84 years. However, in the oldest age groups, namely 90-94 and >95 years, moderate frailty was significantly higher relative to the younger groups (21% and 34%, p < 0.05, p < 0.01 respectively). Home help hours significantly correlated with frailty (rs = 0.371, p < 0.001) and functional dependency (rs = 0.609, p < 0.001), but only weakly with age (rs = 0.101, p = 0.034). Based on regression analysis, determinants of frailty included greater dependency (Barthel score), higher home help hours, non-self-caring and communication difficulty, all of which significantly contributed to the model, with a r squared value of 0.508. A high prevalence of frailty (41.5%) was documented in this population which associated with higher home help utilisation. Frailty was associated with greater functional dependency, but not strongly with chronological age, until after 90 years. These findings highlight opportunities for developing intervention strategies targeted at ageing in place among home help users.

  1. Improvement in the estimation of cardiovascular risk by carotid intima-medial thickness: A report from the Dublin Cardiohealth station study

    PubMed Central

    Cooney, Maeve; Cooney, Marie -Therese; Maher, Vincent; Khan, Barket; Leong, Tora; Graham, Ian

    2015-01-01

    Background The 5th Joint Task Force European guidelines on cardiovascular disease (CVD) prevention recommend the measurement of carotid intima-media thickness (CIMT) in asymptomatic individuals at moderate risk (Class IIa). We aimed to evaluate the ability of CIMT to further risk stratify patients. Design Cross-sectional study. Methods Patients aged over 18 years free of known CVD at moderate, high, or very high risk of CVD were included. The Panasonic Cardiohealth station, a semi-automated ultrasound system, was used to detect carotid plaque and measure CIMT. Elevated CIMT was defined as =/> 0.9 mm. We analyzed the percentage of those at moderate risk reclassified after addition of CIMT. Results Two hundred patients were included (55% women, mean age 57 years, 12% diabetic); 64%, 23% and 13% were classified as moderate, high, and very high risk, respectively. Across these risk categories, 17%, 33%, and 46% had elevated IMT, p for trend < 0.001. With the addition of CIMT, 13.9% (95% CI: 5.7% to 22.1%) of women and 20.4% (95% CI: 8.7% to 32.1%) of men initially moderate risk were reclassified. Conclusions CIMT measurement reclassifies a considerable percentage of those at moderate risk based on traditional risk factors alone. PMID:26844144

  2. The Persistence of Sperm and the Development of Time Since Intercourse (TSI) Guidelines in Sexual Assault Cases at Forensic Science Ireland, Dublin, Ireland.

    PubMed

    Casey, David G; Domijan, Katarina; MacNeill, Sarah; Rizet, Damien; O'Connell, Declan; Ryan, Jennifer

    2016-12-23

    The persistence of sperm using confirmatory microscopic analysis, the persistence of sperm with tails, time since intercourse (TSI) analysis, and results from the acid phosphatase (AP) reaction from approximately 5581 swabs taken from circa 1450 sexual assault cases are presented. The observed proportions of sperm in the vagina and anus declines significantly after 48 h TSI, and sperm on oral swabs were observed up to 15 h TSI. The AP reaction as a predictor of sperm on intimate swabs is questioned. All AP reaction times gave a low true positive rate; 23% of sperm-positive swabs gave a negative AP reaction time. We show the AP reaction is an unsafe and an unreliable predictor of sperm on intimate swabs. We propose that TSI not AP informs precase assessment and the evaluative approach for sexual assault cases. To help inform an evaluative approach, TSI guidelines are presented.

  3. Workshop Proceedings for USAF Institute for National Security Studies: Combatting Fissile Materials Smuggling Workshop #5, Held in Dublin, California, 3-4 February 1998.

    DTIC Science & Technology

    1999-02-01

    medical isotopes which, although extremely toxic , cannot be used to create a nuclear detonation in a bomb. 21 Combatting Fissile Materials Smuggling...other toxic substances into U.S. markets. Now, our programs to stop nuclear smuggling in the NIS are better conceived and more professionally managed...5 3-4 February 1998 - the commercial strategy and nuclear cooperation, - the brain drain, - the necessity to maintain the appearance of global

  4. Innovations in Curriculum and Examinations at Second Level. Proceedings of the National Modern Languages Convention (1st, Trinity College, Dublin, Ireland, January 29-30, 1982).

    ERIC Educational Resources Information Center

    Ruane, Mary, Ed.; Singleton, David, Ed.

    The papers focus on an overview of current developments, language needs of secondary students, and the status of syllabus and examination changes. In addition to the opening and closing addresses and reports from 15 informal workshops, six papers are provided on such topics as reasons for learning a foreign language (A.R. Clarke and others), the…

  5. Relapsing herpes simplex encephalitis resulting in Kluver-Bucy syndrome.

    PubMed

    Ku, Bon D; Yoon, Sung Sang

    2011-01-01

    Relapsing herpes simplex encephalitis (HSE) rarely occurs after acyclovir treatment. We treated a patient with relapsing HSE of the contralateral temporal lobe, resulting in Klüver-Bucy syndrome, after a full-dose acyclovir treatment. This case suggests that physicians should consider sudden behavioral and emotional changes after HSE treatment as a possible indication of relapsing HSE, as well as possible temporal lobe epilepsy, and the need to administer longer acyclovir treatment for select patients.

  6. Human Systems Engineering: A Leadership Model for Collaboration and Change.

    ERIC Educational Resources Information Center

    Clark, Karen L.

    Human systems engineering (HSE) was created to introduce a new way of viewing collaboration. HSE emphasizes the role of leaders who welcome risk, commit to achieving positive change, and help others achieve change. The principles of HSE and its successful application to the collaborative process were illustrated through a case study representing a…

  7. 78 FR 23886 - Notice of Intent To Grant Exclusive License

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-23

    ..., Agricultural Research Service, intends to grant to Biosortia Pharmaceuticals of Dublin, Ohio, an exclusive... the public interest to so license this invention as Biosortia Pharmaceuticals of Dublin, Ohio has...

  8. Herpes simplex encephalitis: some interesting presentations.

    PubMed

    Jha, S; Jose, M; Kumar, V

    2003-09-01

    Herpes Simplex Encephalitis (HSE) is the most common cause of fatal viral encephalitis. A high index of suspicion is mandatory for early diagnosis and successful therapy to restrict morbidity and mortality. We report 4 patients of HSE, with interesting presentations, viz. brainstem involvement in an immunosuppressed patient, Kluver-Bucy Syndrome-a consequence of untreated HSE, HSE in the postpartum period mistaken as cortical venous thrombosis, and response to inadequate treatment. They demonstrate the wide spectrum of clinical features, pitfalls in diagnosis, and a variable response to therapy in HSE.

  9. The Stage and the City: Narrative, Identity and Place in Dermot Bolger's "The Ballymun Trilogy" (2004-2008)

    ERIC Educational Resources Information Center

    Malone, Niamh; O'Sullivan, Carmel

    2011-01-01

    Located two miles from Dublin Airport, Ballymun was built (1966-9) to accommodate people displaced from the inner-city slums dramatised in Sean O'Casey's Dublin Trilogy. "The Stage and the City" draws on the author's research project at Trinity College Dublin, on Theatre and Urban Regeneration. Specifically, it situates Dermot Bolger's…

  10. The Stage and the City: Narrative, Identity and Place in Dermot Bolger's "The Ballymun Trilogy" (2004-2008)

    ERIC Educational Resources Information Center

    Malone, Niamh; O'Sullivan, Carmel

    2011-01-01

    Located two miles from Dublin Airport, Ballymun was built (1966-9) to accommodate people displaced from the inner-city slums dramatised in Sean O'Casey's Dublin Trilogy. "The Stage and the City" draws on the author's research project at Trinity College Dublin, on Theatre and Urban Regeneration. Specifically, it situates Dermot Bolger's…

  11. When do ego threats lead to self-regulation failure? Negative consequences of defensive high self-esteem.

    PubMed

    Lambird, Kathleen Hoffman; Mann, Traci

    2006-09-01

    High self-esteem (HSE) is increasingly recognized as heterogeneous. By measuring subtypes of HSE, the present research reevaluates the finding that HSE individuals show poor self-regulation following ego threat (Baumeister, Heatherton, & Tice, 1993). In Experiment 1, participants with HSE showed poor self-regulation after ego threat only if they also were defensive (high in self-presentation bias). In Experiment 2, two measures--self-presentation bias and implicit self-esteem--were used to subtype HSE individuals as defensive. Both operationalizations of defensive HSE predicted poor self-regulation after ego threat. The results indicate that (a) only defensive HSE individuals are prone to self-regulation failure following ego threat and (b) measures of self-presentation bias and implicit self-esteem can both be used to detect defensiveness.

  12. Hibiscus sabdariffa extract inhibits obesity and fat accumulation, and improves liver steatosis in humans.

    PubMed

    Chang, Hong-Chou; Peng, Chiung-Huei; Yeh, Da-Ming; Kao, Erl-Shyh; Wang, Chau-Jong

    2014-04-01

    Obesity is associated with a great diversity of diseases including non-alcoholic fatty liver disease. Our previous report suggested that Hibiscus sabdariffa extracts (HSE) had a metabolic-regulating and liver-protecting potential. In this study, we performed a clinical trial to further confirm the effect of HSE. Subjects with a BMI ≧ 27 and aged 18-65, were randomly divided into control (n = 17) and HSE-treated (n = 19) groups, respectively, for 12 weeks. Our data showed that consumption of HSE reduced body weight, BMI, body fat and the waist-to-hip ratio. Serum free fatty acid (FFA) was lowered by HSE. Anatomic changes revealed that HSE improved the illness of liver steatosis. Ingestion of HSE was well tolerated and there was no adverse effect during the trial. No alteration was found for serum α-amylase and lipase. The clinical effect should mainly be attributed to the polyphenols of HSE, since composition analysis showed that branched chain-amino acids, which is associated with obesity, is not obviously high. In conclusion, consumption of HSE reduced obesity, abdominal fat, serum FFA and improved liver steatosis. HSE could act as an adjuvant for preventing obesity and non-alcoholic fatty liver.

  13. The Less Widely Taught Languages of Europe. Proceedings of the Joint United Nations Educational, Scientific, and Cultural Organization, International Association of Applied Linguistics, and Irish Association of Applied Linguistics Symposium (St. Patrick's College, Dublin, Ireland, April 23-25, 1987).

    ERIC Educational Resources Information Center

    Mathuna, Liam Mac, Ed.; And Others

    Papers presented at a symposium on Europe's less commonly taught languages include the following: "The Necessity of Dialogue" (Marcel de Greve); "Socio- and Psycholinguistic Interference in Teaching Foreign Languages" (Penka Ilieva-Baltova); "Satellite Television, National Television, and Video in Teaching/Learning Less…

  14. A bill to designate the facility of the United States Postal Service located at 715 Shawan Falls Drive in Dublin, Ohio, as the "Lance Corporal Wesley G. Davids and Captain Nicholas J. Rozanski Memorial Post Office".

    THOMAS, 113th Congress

    Sen. Brown, Sherrod [D-OH

    2014-11-12

    Senate - 11/12/2014 Read twice and referred to the Committee on Homeland Security and Governmental Affairs. (All Actions) Notes: For further action, see H.R.4919, which became Public Law 113-222 on 12/16/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  15. The European Network for Research, Action and Training in Adult Literacy and Basic Education (Dublin, Ireland, May 25-30, 1991). A Seminar Organised by EUROALPHA. Adult Basic Education in Prisons.

    ERIC Educational Resources Information Center

    1991

    This conference report on adult basic education in European prisons contains the following introductory materials: a list of participants, the program, and introductions to the seminar by Frank Dunne and Pierre Freynet. "Keynote Address" (Robert Suvaal) discusses five items a prison educator must deal with: philosophy, position of…

  16. Information Technology and Development Series. Volume 2. Informatics and Industrial Development. Proceedings of the International Conference on Policies for Information Processing for Developing Countries Held at Dublin, Ireland on 9-13 March 1981,

    DTIC Science & Technology

    1982-11-01

    having an important impact on most if not all industri’ sectors both manufacturing and srvices . The National Board for Science and Technology (NPS-i...it has to be appropriate. Its appropriateness has been defined as "’harmonious with social, economic and ecological conditions and it has to foster

  17. A bill to designate the facility of the United States Postal Service located at 715 Shawan Falls Drive in Dublin, Ohio, as the "Lance Corporal Wesley G. Davids and Captain Nicholas J. Rozanski Memorial Post Office".

    THOMAS, 113th Congress

    Sen. Brown, Sherrod [D-OH

    2014-11-12

    11/12/2014 Read twice and referred to the Committee on Homeland Security and Governmental Affairs. (All Actions) Notes: For further action, see H.R.4919, which became Public Law 113-222 on 12/16/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  18. Proceedings of the International Association for Development of the Information Society (IADIS) International Conference on Cognition and Exploratory Learning in the Digital Age (CELDA) (12th, Maynooth, Greater Dublin, Ireland, October 24-26, 2015)

    ERIC Educational Resources Information Center

    Sampson, Demetrios G., Ed.; Spector, J. Michael, Ed.; Ifenthaler, Dirk, Ed.; Isaias, Pedro, Ed.

    2015-01-01

    These proceedings contain the papers of the 12th International Conference on Cognition and Exploratory Learning in the Digital Age (CELDA 2015), October 24-26, 2015, which has been organized by the International Association for Development of the Information Society (IADIS), co-organized by Maynooth University, Ireland, and endorsed by the…

  19. A bill to designate the facility of the United States Postal Service located at 715 Shawan Falls Drive in Dublin, Ohio, as the "Lance Corporal Wesley G. Davids and Captain Nicholas J. Rozanski Memorial Post Office".

    THOMAS, 113th Congress

    Sen. Brown, Sherrod [D-OH

    2014-11-12

    11/12/2014 Read twice and referred to the Committee on Homeland Security and Governmental Affairs. (All Actions) Notes: For further action, see H.R.4919, which became Public Law 113-222 on 12/16/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  20. [Kluver Bucy syndrome and central diabetes insipidus: two uncommon complications of herpes simplex encephalitis].

    PubMed

    Locatelli, C; Vergine, G; Ciambra, R; Leone, V; Facchini, S; Suprani, T; Casadei, G; Pocecco, M

    2003-01-01

    Herpes Simplex Encephalitis (HSE) is an uncommon but severe disease with high mortality and morbidity. The major clinical manifestations are deteriorating consciousness with confusion, drowsiness or coma, altered behaviour, convulsions and a variety of neurological signs (hemiplegia, aphasia, ataxia, etc.). An uncommon complication of HSE is Kluver Bucy syndrome (KBS), characterized by hyperorality, bulimia and changes in emotional behaviour. Neuroimaging studies frequently show an involvement of the temporal lobes and limbic areas. Another uncommon complication of HSE is central diabetes insipidus as a result of herpes simplex infection of the hypothalamus. We report two pediatric cases of HSE complicated with Kluver Bucy syndrome and central diabetes insipidus.

  1. Extratemporal herpes encephalitis during natalizumab treatment: A case report.

    PubMed

    Haggiag, Shalom; Prosperini, Luca; Galgani, Simonetta; Pozzilli, Carlo; Pinnetti, Carmela

    2016-11-01

    Herpes simplex virus encephalitis (HSE) is a rare but often fatal disease if left untreated. MRI typically shows the characteristic findings of medial temporal lobe and insular involvement, while diagnosis in confirmed by CSF PCR. In immunocompromised state, HSE may have atypical clinical and radiological features. We report a MS patient under natalizumab treatment with HSE, who presented with MRI lesions exclusively in the right parietal lobe. The patient was timely started on acyclovir resulting in marked improvement. A high index of suspicion for HSE should be maintained when a patient presents with fever and extratemporal lesions, even more in immunocompromised subjects.

  2. Herpes Simplex Encephalitis Complicated by Cerebral Hemorrhage during Acyclovir Therapy

    PubMed Central

    Harada, Yukinori; Hara, Yuuta

    2017-01-01

    Herpes simplex encephalitis (HSE) can be complicated by adverse events in the acute phase. We herein present the case of a 71-year-old woman with HSE complicated by cerebral hemorrhage. She presented with acute deterioration of consciousness and fever and was diagnosed with HSE based on the detection of herpes simplex virus-1 in the cerebrospinal fluid by a polymerase chain reaction. The cerebral hemorrhage developed during acyclovir therapy; however, its diagnosis was delayed for 2 days. After the conservative treatment of the cerebral hemorrhage, the patient made a near-complete recovery. Cerebral hemorrhage should be considered as an acute-phase complication of HSE. PMID:28090058

  3. Identification of an immunodominant epitope in glycoproteins B and G of herpes simplex viruses (HSVs) using synthetic peptides as antigens in assay of antibodies to HSV in herpes simplex encephalitis patients.

    PubMed

    Bhullar, S S; Chandak, N H; Baheti, N N; Purohit, H J; Taori, G M; Daginawala, H F; Kashyap, R S

    2014-01-01

    Herpes simplex encephalitis (HSE) is a severe viral infection of the central nervous system (CNS). Assay of antibody response is widely used in diagnostics of HSE. The aim of this study was to identify an immunodominant epitope determining the antibody response to herpes simplex viruses (HSVs) in cerebrospinal fluid (CSF) of HSE patients. The synthetic peptides that resembled type-common as well as type-specific domains of glycoproteins B (gB) and G (gG) of these viruses were evaluated for binding with IgM and IgG antibodies in CSF samples from HSE and non-HSE patients in ELISA. The QLHDLRF peptide, derived from gB of HSV was found to be an immunodominant epitope in the IgM and IgG antibody response. The patients with confirmed and suspected HSE showed in ELISA against this peptide 26% and 23% positivities for IgM, 43% and 37% positivities for IgG and 17% and 15% for both IgM and IgG antibodies, respectively. The total positivities of 86% and 75% for both IgM and IgG antibodies were obtained in the patients with confirmed and suspected HSE, respectively. These results demonstrate that a synthetic peptide-based diagnostics of HSE can be an efficient and easily accessible alternative. This is the first report describing the use of synthetic peptides derived from HSVs in diagnostics of HSE using patientsʹ CSF samples.

  4. Osmium Isotope and Highly Siderophile Element Compositions of Lunar Orange and Green Glasses

    NASA Technical Reports Server (NTRS)

    Walker, R. J.; Horan, M. F.; Shearer, C. K.; Papike, J. J.

    2003-01-01

    The absolute and relative abundances of the highly siderophile elements (HSE) present in planetary mantles are primarily controlled by: 1) silicate-metal partitioning during core-mantle differentiation, 2) the subsequent addition of HSE to mantles via continued planetary accretion. Consequently, constraints on the absolute and relative abundances of the HSE in the lunar mantle will provide unique insights to the formation and late accretionary history of not only the Moon, but also Earth. Determining the HSE content of the lunar mantle, however, has proven difficult, because no bona fide mantle rocks have been collected from the moon. The only materials presently available for constraining mantle abundances are lunar volcanic rocks. Lunar basalts typically have very low concentrations of HSE and highly fractionated HSE patterns. Because of our extremely limited understanding of mantle melt partitioning of the HSE, even for terrestrial systems, extrapolations to mantle compositions from basaltic compositions are difficult, except possibly for the less compatible HSE Pt and Pd. Primitive, presumably less fractionated materials, such as picritic glasses are potentially more diagnostic of the lunar interior. Here we report Os isotopic composition data and Re, Os, Ir, Ru, Pt and Pd concentration data for green glass (15426,164) and orange glass (74001,1217). As with previous studies utilizing neutron activation analysis, we are examining different size fractions of the spherules to assess the role of surface condensation in the generation of the HSE abundances.

  5. Osmium Isotope and Highly Siderophile Element Compositions of Lunar Orange and Green Glasses

    NASA Technical Reports Server (NTRS)

    Walker, R. J.; Horan, M. F.; Shearer, C. K.; Papike, J. J.

    2003-01-01

    The absolute and relative abundances of the highly siderophile elements (HSE) present in planetary mantles are primarily controlled by: 1) silicate-metal partitioning during core-mantle differentiation, 2) the subsequent addition of HSE to mantles via continued planetary accretion. Consequently, constraints on the absolute and relative abundances of the HSE in the lunar mantle will provide unique insights to the formation and late accretionary history of not only the Moon, but also Earth. Determining the HSE content of the lunar mantle, however, has proven difficult, because no bona fide mantle rocks have been collected from the moon. The only materials presently available for constraining mantle abundances are lunar volcanic rocks. Lunar basalts typically have very low concentrations of HSE and highly fractionated HSE patterns. Because of our extremely limited understanding of mantle melt partitioning of the HSE, even for terrestrial systems, extrapolations to mantle compositions from basaltic compositions are difficult, except possibly for the less compatible HSE Pt and Pd. Primitive, presumably less fractionated materials, such as picritic glasses are potentially more diagnostic of the lunar interior. Here we report Os isotopic composition data and Re, Os, Ir, Ru, Pt and Pd concentration data for green glass (15426,164) and orange glass (74001,1217). As with previous studies utilizing neutron activation analysis, we are examining different size fractions of the spherules to assess the role of surface condensation in the generation of the HSE abundances.

  6. Herpes Simplex Encephalitis Complicated by Cerebral Hemorrhage during Acyclovir Therapy.

    PubMed

    Harada, Yukinori; Hara, Yuuta

    2017-01-01

    Herpes simplex encephalitis (HSE) can be complicated by adverse events in the acute phase. We herein present the case of a 71-year-old woman with HSE complicated by cerebral hemorrhage. She presented with acute deterioration of consciousness and fever and was diagnosed with HSE based on the detection of herpes simplex virus-1 in the cerebrospinal fluid by a polymerase chain reaction. The cerebral hemorrhage developed during acyclovir therapy; however, its diagnosis was delayed for 2 days. After the conservative treatment of the cerebral hemorrhage, the patient made a near-complete recovery. Cerebral hemorrhage should be considered as an acute-phase complication of HSE.

  7. Production of Optical Quality Free Standing Diamond Wafer

    DTIC Science & Technology

    2008-05-19

    Title : Production of Optical Quality Free Standing Diamond Wafer Prime Contractor : Onyx Optics, Inc. 6551 Sierra Lane Dublin, Ca 94568...www.onyxoptics.com Program Manager : Helmuth Meissner Onyx Optics, Inc. 6551 Sierra Lane Dublin, CA 94568 Email: hmeissner@onyxoptics.com Ph: 925...PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Onyx Optics, Inc. 6551 Sierra Lane Dublin, Ca 94568 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING

  8. Evaluation of holistic sexuality education: A European expert group consensus agreement.

    PubMed

    Ketting, Evert; Friele, Minou; Michielsen, Kristien

    2016-01-01

    Holistic sexuality education (HSE) is a new concept in sexuality education (SE). Since it differs from other types of SE in a number of important respects, strategies developed for the evaluation of the latter are not necessarily applicable to HSE. In this paper the authors provide a basis for discussion on how to evaluate HSE. First, the international literature on evaluation of SE in general was reviewed in terms of its applicability to HSE. Second, the European Expert Group on Sexuality Education extensively discussed the requirements of its evaluation and suggested appropriate indicators and methods for evaluating HSE. The European experience in SE is scarcely represented in the general evaluation literature. The majority of the literature focuses on impact and neglects programme and implementation evaluations. Furthermore, the current literature demonstrates that evaluation criteria predominantly focus on the public health impact, while there is not yet a consensus on sexual well-being criteria and aspects of positive sexuality, which are crucial parts of HSE. Finally, experimental designs are still considered the gold standard, yet several of the conditions for their use are not fulfilled in HSE. Realising that a new evaluation framework for HSE is needed, the European expert group initiated its development and agreed upon a number of indicators that provide a starting point for further discussion. Aside from the health impact, the quality of SE programmes and their implementation also deserve attention and should be evaluated. To be applicable to HSE, the evaluation criteria need to cover more than the typical public health aspects. Since they do not register long-term and multi-component characteristics, evaluation methods such as randomised controlled trials are not sufficiently suitable for HSE. The evaluation design should rely on a number of different information sources from mixed methods that are complemented and triangulated to build a plausible case

  9. Protective role of Hibiscus sabdariffa calyx extract against streptozotocin induced sperm damage in diabetic rats

    PubMed Central

    Idris, Muhd Hanis Md; Budin, Siti Balkis; Osman, Mohamad; Mohamed, Jamaludin

    2012-01-01

    Diabetes mellitus contributes to male sexual dysfunction and infertility by modulating oxidative damage. To date, a number of studies have demonstrated antioxidant properties of Hibiscus sabdariffa Linn. This study was designed to investigate the effects of H. sabdariffa UKMR-2 variety on sperm functioning of streptozotocin-induced diabetic rats. Male Sprague-Dawley rats were allotted into four groups, namely control group (C), H. sabdariffa extract (HSE) group, diabetes group (D) and diabetes plus HSE group (D+HSE). HSE (100 mg/ kg/body weight) was administered orally for 28 consecutive days. After 28-days of supplementation, the rats were sacrificed to obtain epididymal sperm. Administration of HSE significantly lowered the level of fasting blood glucose and increased plasma insulin level in D+HSE group as compared to D group (p<0.05). Sperm quality in the D+HSE group was improved with significantly higher sperm concentrations (p<0.05) and sperm motility (p<0.001) as well as lower percentage of sperm abnormality (p<0.05) as compared to the diabetic group. Plasma follicle-stimulating hormone (FSH) level was significantly elevated (p<0.05) in D+HSE group than in D group while no significant alteration in plasma testosterone and luteinizing hormone (LH) level were seen between groups. In conclusion, this study suggested that H. sabdariffa UKMR-2 variety has a potential protective role against diabetes-induced sperm damage. PMID:27847454

  10. Performance management of the public healthcare services in Ireland: a review.

    PubMed

    Mesabbah, Mohammed; Arisha, Amr

    2016-01-01

    Performance Management (PM) processes have become a potent part of strategic and service quality decisions in healthcare organisations. In 2005, the management of public healthcare in Ireland was amalgamated into a single integrated management body, named the Health Service Executive (HSE). Since then, the HSE has come up with a range of strategies for healthcare developments and reforms, and has developed a PM system as part of its strategic planning. The purpose of this paper is to review the application of PM in the Irish Healthcare system, with a particular focus on Irish Hospitals and Emergency Services. An extensive review of relevant HSE's publications from 2005 to 2013 is conducted. Studies of the relevant literature related to the application of PM and of international best practices in healthcare performance systems are also presented. PM and performance measurement systems used by the HSE include many performance reports designed to monitor performance trends and strategic goals. Issues in the current PM system include inconsistency of measures and performance reporting, unclear strategy alignment, and deficiencies in reporting (e.g. feedback and corrective actions). Furthermore, PM processes have not been linked adequately into Irish public hospitals' management systems. The HSE delivers several services such as mental health, social inclusion, etc. This study focuses on the HSE's PM framework, with a particular interest in acute hospitals and emergency services. This is the first comprehensive review of Irish healthcare PM since the introduction of the HSE. A critical analysis of the HSE reports identifies the shortcomings in its current PM system.

  11. The case for immunomodulatory approaches in treating HSV encephalitis

    PubMed Central

    Ramakrishna, Chandran; Openshaw, Harry; Cantin, Edouard M

    2013-01-01

    HSV encephalitis (HSE) is the most prevalent sporadic viral encephalitis. Although safe and effective antiviral therapies and greatly improved noninvasive diagnostic procedures have significantly improved outcomes, mortality (~20%) and debilitating neurological sequelae in survivors remain unacceptably high. An encouraging new development is that the focus is now shifting away from the virus exclusively, to include consideration of the host immune response to infection in the pathology underlying development of HSE. In this article, the authors discuss results from recent studies in experimental mouse models, as well as clinical reports that demonstrate a role for exaggerated host inflammatory responses in the brain in the development of HSE that is motivating researchers and clinicians to consider new therapeutic approaches for treating HSE. The authors also discuss results from a few studies that have shown that immunomodulatory drugs can be highly protective against HSE, which supports a role for deleterious host inflammatory responses in HSE. The impressive outcomes of some immunomodulatory approaches in mouse models of HSE emphasize the urgent need for clinical trials to rigorously evaluate combination antiviral and immunomodulatory therapy in comparison with standard antiviral therapy for treatment of HSE, and support for such an initiative is gaining momentum. PMID:23956785

  12. Diagnosis of Herpes Simplex Encephalitis by ELISA Using Antipeptide Antibodies Against Type-Common Epitopes of Glycoprotein B of Herpes Simplex Viruses.

    PubMed

    Bhullar, Shradha S; Chandak, Nitin H; Baheti, Neeraj N; Purohit, Hemant J; Taori, Girdhar M; Daginawala, Hatim F; Kashyap, Rajpal S

    2016-01-01

    Herpes simplex encephalitis (HSE) represents one of the most severe infectious diseases of the central nervous system (CNS). As effective antiviral drugs are available, an early, rapid, and reliable diagnosis has become important. The objective of this article was to develop a sensitive ELISA protocol for herpes simplex viruses (HSV) antigen detection and quantitation by assessing the usefulness of antipeptide antibodies against potential peptides of HSV glycoprotein B (gB). A total of 180 cerebrospinal fluid (CSF) samples of HSE and non-HSE patients were analyzed using a panel of antipeptide antibodies against synthetic peptides of HSV glycoprotein gB. The cases of confirmed and suspected HSE showed 80% and 51% positivity for antipeptide against synthetic peptide QLHDLRF and 77% and 53% positivity for antipeptide against synthetic peptide MKALYPLTT, respectively for the detection of HSV antigen in CSF. The concentration of HSV antigen was found to be higher in confirmed HSE as compared to suspected HSE group and the viral load correlated well with antigen concentration obtained using the two antipeptides in CSF of confirmed HSE group. This is the first article describing the use of antibodies obtained against synthetic peptides derived from HSV in diagnostics of HSE using patients' CSF samples.

  13. Pediatric Herpes Simplex Virus Encephalitis Complicated by N-Methyl-D-aspartate Receptor Antibody Encephalitis.

    PubMed

    Bamford, Alasdair; Crowe, Belinda H A; Hacohen, Yael; Lin, Jean-Pierre; Clarke, Antonia; Tudor-Williams, Gareth; Sancho-Shimizu, Vanessa; Vincent, Angela; Lim, Ming; Pullaperuma, Sunil P

    2015-06-01

    N-methyl-D-aspartate receptor antibodies (NMDAR-Abs) can contribute to neurological relapse after herpes simplex virus encephalitis (HSE). We describe a child with NMDAR-Ab encephalitis after HSE, which was recognized and treated early. We discuss the case in the context of existing reports, and we propose a modified immunotherapy strategy to minimize risk of viral reactivation.

  14. Health systems engineering fellowship: curriculum and program development.

    PubMed

    Watts, Bradley V; Shiner, Brian; Cully, Jeffrey A; Gilman, Stuart C; Benneyan, James C; Eisenhauer, William

    2015-01-01

    Industrial engineering and related disciplines have been used widely in improvement efforts in many industries. These approaches have been less commonly attempted in health care. One factor limiting application is the limited workforce resulting from a lack of specific education and professional development in health systems engineering (HSE). The authors describe the development of an HSE fellowship within the United States Department of Veterans Affairs, Veterans Health Administration (VA). This fellowship includes a novel curriculum based on specifically established competencies for HSE. A 1-year HSE curriculum was developed and delivered to fellows at several VA engineering resource centers over several years. On graduation, a majority of the fellows accepted positions in the health care field. Challenges faced in developing the fellowship are discussed. Advanced educational opportunities in applied HSE have the potential to develop the workforce capacity needed to improve the quality of health care.

  15. Health, safety, and environmental management system operation in contracting companies: A case study.

    PubMed

    Nassiri, Parvin; Yarahmadi, Rasoul; Gholami, Pari Shafaei; Hamidi, Abdolamir; Mirkazemi, Roksana

    2016-05-03

    Systematic and cooperative interactions among parent industry and contractors are necessary for a successful health, safety, and environmental management system (HSE-MS). This study was conducted to evaluate the HSE-MS performance in contracting companies in one of the petrochemical industries in Iran during 2013. Managers of parent and contracting companies participated in this study. The data collection forms included 7 elements of an integrated HSE-MS (leadership and commitment; policy and strategic objectives; organization, resources, and documentation; evaluation and risk management; planning; implementation and monitoring; auditing and reviewing). The results showed that mean percentage of the total scores in seven elements of HSE-MS was 85.7% and 87.0% based on self-report and report of parent company, respectively. In conclusion, this study showed that HSE-MS was desirably functioning; however, improvement to ensure health and safety of workers is still required.

  16. Herpes simplex virus encephalitis is a trigger of brain autoimmunity.

    PubMed

    Armangue, Thaís; Leypoldt, Frank; Málaga, Ignacio; Raspall-Chaure, Miquel; Marti, Itxaso; Nichter, Charles; Pugh, John; Vicente-Rasoamalala, Monica; Lafuente-Hidalgo, Miguel; Macaya, Alfons; Ke, Michael; Titulaer, Maarten J; Höftberger, Romana; Sheriff, Heather; Glaser, Carol; Dalmau, Josep

    2014-02-01

    In 5 prospectively diagnosed patients with relapsing post-herpes simplex encephalitis (HSE), N-methyl-D-aspartate receptor (NMDAR) antibodies were identified. Antibody synthesis started 1 to 4 weeks after HSE, preceding the neurological relapse. Three of 5 patients improved postimmunotherapy, 1 spontaneously, and 1 has started to improve. Two additional patients with NMDAR antibodies, 9 with unknown neuronal surface antibodies, and 1 with NMDAR and unknown antibodies, were identified during retrospective assessment of 34 HSE patients; the frequency of autoantibodies increased over time (serum, p=0.004; cerebrospinal fluid, p=0.04). The 3 retrospectively identified NMDAR antibody-positive patients also had evidence of relapsing post-HSE. Overall, these findings indicate that HSE triggers NMDAR antibodies and potentially other brain autoimmunity.

  17. Effect of Hibiscus sabdariffa extract on high fat diet–induced obesity and liver damage in hamsters

    PubMed Central

    Huang, To-Wei; Chang, Chia-Ling; Kao, Erl-Shyh; Lin, Jenq-Horng

    2015-01-01

    Background Obesity is a chronic metabolic disorder associated with an increase in adipogenesis and often accompanied with fatty liver disease. Objective In this study, we investigated the anti-obesity effects of Hibiscus sabdariffa water extract (HSE) in vivo. Method Eight-weeks-old male mice were divided into six groups (n=8 per group) and were fed either normal feed, a high fat diet (HFD), HFD supplemented with different concentrations of HSE, or HFD supplemented with anthocyanin. After 10 weeks of feeding, all the blood and livers were collected for further analysis. Results Mesocricetus auratus hamster fed with a high-fat diet developed symptoms of obesity, as determined from their body weight change and from their plasma lipid levels. Meanwhile, HSE treatment reduced fat accumulation in the livers of hamsters fed with HFD in a concentration-dependent manner. Administration of HSE reduced the levels of liver cholesterol and triglycerides, which were elevated by HFD. Analysis of the effect of HSE on paraoxonase 1, an antioxidant liver enzyme, revealed that HSE potentially regulates lipid peroxides and protects organs from oxidation-associated damage. The markers of liver damage such as serum alanine aminotransferase and aspartate aminotransferase levels that were elevated by HFD were also reduced on HSE treatment. The effects of HSE were as effective as treatment with anthocyanin; therefore the anthocyanins present in the HSE may play a crucial role in the protection established against HFD-induced obesity. Conclusions In conclusion HSE administration constitutes an effective and viable treatment strategy against the development and consequences of obesity. PMID:26475512

  18. Zinc- and bicarbonate-dependent ZIP8 transporter mediates selenite uptake

    PubMed Central

    McDermott, Joseph R.; Geng, Xiangrong; Jiang, Lan; Gálvez-Peralta, Marina; Chen, Fei; Nebert, Daniel W.; Liu, Zijuan

    2016-01-01

    Selenite (HSeO3−) is a monovalent anion of the essential trace element and micronutrient selenium (Se). In therapeutic concentrations, HSeO3− has been studied for treating certain cancers, serious inflammatory disorders, and septic shock. Little is known, however, about HSeO3− uptake into mammalian cells; until now, no mammalian HSeO3− uptake transporter has been identified. The ubiquitous mammalian ZIP8 divalent cation transporter (encoded by the SLC39A8 gene) is bicarbonate-dependent, moving endogenous substrates (Zn2+, Mn2+, Fe2+ or Co2+) and nonessential metals such as Cd2+ into the cell. Herein we studied HSeO3− uptake in: human and mouse cell cultures, shRNA-knockdown experiments, Xenopus oocytes, wild-type mice and two transgenic mouse lines having genetically altered ZIP8 expression, and mouse erythrocytes ex vivo. In mammalian cell culture, excess Zn2+ levels and/or ZIP8 over-expression can be associated with diminished viability in selenite-treated cells. Intraperitoneal HSeO3− causes the largest ZIP8-dependent increases in intracellular Se content in liver, followed by kidney, heart, lung and spleen. In every model system studied, HSeO3− uptake is tightly associated with ZIP8 protein levels and sufficient Zn2+ and HCO3− concentrations, suggesting that the ZIP8-mediated electroneutral complex transported contains three ions: Zn2+/(HCO3−)(HSeO3−). Transporters having three different ions in their transport complex are not without precedent. Although there might be other HSeO3− influx transporters as yet undiscovered, data herein suggest that mammalian ZIP8 plays a major role in HSeO3− uptake. PMID:27166256

  19. A Case Study: Problem-Based Learning for Civil Engineering Students in Transportation Courses

    ERIC Educational Resources Information Center

    Ahern, A. A.

    2010-01-01

    This paper describes two case studies where problem-based learning (PBL) has been introduced to undergraduate civil engineering students in University College Dublin. PBL has recently been put in place in the penultimate and final year transport engineering classes in the civil engineering degree in University College Dublin. In this case study,…

  20. Online Database for the Assessment and Comparative Evaluation of Rehabilitation Outcomes

    DTIC Science & Technology

    2007-11-02

    National University of Ireland, Maynooth, Ireland 2School of Physiotherapy , University College Dublin, Dublin, Ireland Report Documentation Page...outcome measures database?” Physiotherapy , vol. 85, pp. 234-235, 1999 [3] M. Torenbeek, B. Caulfield, W. van Harten, M. Garrett, “ACROSS: Current use of

  1. DC-5: The Helsinki Metadata Workshop. A Report on the Workshop and Subsequent Developments.

    ERIC Educational Resources Information Center

    Weibel, Stuart; Hakala, Juha

    1998-01-01

    Offers a brief history of the Dublin Core initiative, an international, interdisciplinary effort to define a core set of elements for resource discovery. Describes outcomes of Dublin Core Workshops 1-4. Discusses outcomes of the Helsinki Metadata Workshop, focusing on the "Finnish Finish" which will form the basis of the first formal…

  2. Exploring Non-Thermal Radiofrequency Bioeffects for Novel Military Applications

    DTIC Science & Technology

    2006-11-30

    Bioelectromagnetics Society and the European BioElectromagnetics Association, Dublin, Ireland, June 2005. Craviso, G. L., Brouse, D., Hagan, T., McPherson, D...Joint Meeting of the Bioelectromagnetics Society and the European BioElectromagnetics Association, Dublin, Ireland, June 2005. c) Other forums: Hagan

  3. Extract from an Interview of Sean O'Connor: 8 September 1986

    ERIC Educational Resources Information Center

    Mulcahy, D. G.; O'Sullivan, Denis

    2014-01-01

    The educational community appreciates the editors of "Irish Educational Studies" for making the Interview with Sean O'Connor, in Dublin, Ireland available to a wider audience in 2014. The interview was originally in Sean O'Connor's home in Dublin on 8 September 1986. By that time, O'Connor had retired as Secretary of the Department of…

  4. Controlling the Production of EAD Encoded Documents, Extracting Metadata and Publishing Them on the Web: Methods and Tools, France

    ERIC Educational Resources Information Center

    Clavaud, Florence; Sevigny, Martin

    2005-01-01

    This article presents four projects geared towards providing the community of EAD users with methods and tools to control the quality of archival finding aids, to extract metadata from them in Dublin Core and qualified Dublin Core for use in OAI-PMH repositories, and to publish them on the Web along with the digital images produced by digitization…

  5. Organizing the Internet: The "Core" of the Challenge.

    ERIC Educational Resources Information Center

    Chepesiuk, Ron

    1999-01-01

    Discussion of how librarians can help organize the Internet focuses on the Dublin Core Metadata Element Set. Topics include OCLC's efforts, the MARC (Machine Readable Cataloging Records) format for cataloging and how it relates to the Dublin Core; the CORC (Cooperative Online Resource Catalog); and Web sites for organizing the Internet. (LRW)

  6. A Case Study: Problem-Based Learning for Civil Engineering Students in Transportation Courses

    ERIC Educational Resources Information Center

    Ahern, A. A.

    2010-01-01

    This paper describes two case studies where problem-based learning (PBL) has been introduced to undergraduate civil engineering students in University College Dublin. PBL has recently been put in place in the penultimate and final year transport engineering classes in the civil engineering degree in University College Dublin. In this case study,…

  7. A Life of Erwin Schrödinger

    NASA Astrophysics Data System (ADS)

    Moore, Walter J.

    1994-09-01

    Introduction; 1. Family childhood, and youth; 2. University of Vienna; 3. Schrödinger at war; 4. From Vienna to Zurich; 5. Zurich; 6. Discovery of wave mechanics; 7. Berlin; 8. Exile in Oxford; 9. Graz; 10. Wartime Dublin; 11. Postwar Dublin; 12. Home to Vienna.

  8. From the Building to the Grid: An Energy Revolution and Modeling Challenge; Workshop Proceedings

    SciTech Connect

    Kroposki, B.; Komomua, C.; O'Malley, M.

    2013-01-01

    This report summarizes the workshop entitled: From the Building to the Grid: An Energy Revolution and Modeling Challenge. The first workshop was held May 1-2, 2012 on NREL's campus in Golden, Colorado. The second was held June 6-7, 2012 at the University College Dublin, in Dublin, Ireland.

  9. Schrödinger

    NASA Astrophysics Data System (ADS)

    Moore, Walter

    2015-10-01

    1. Family, childhood and youth; 2. University of Vienna; 3. Schrödinger at war; 4. From Vienna to Zurich; 5. Zurich; 6. Discovery of wave mechanics; 7. Berlin; 8. Exile in Oxford; 9. Graz; 10. Wartime Dublin; 11. Postwar Dublin; 12. Home to Vienna.

  10. Antitumoral Effect of Hibiscus sabdariffa on Human Squamous Cell Carcinoma and Multiple Myeloma Cells.

    PubMed

    Malacrida, Alessio; Maggioni, Daniele; Cassetti, Arianna; Nicolini, Gabriella; Cavaletti, Guido; Miloso, Mariarosaria

    2016-10-01

    Cancer is a leading cause of death worldwide. Despite therapeutic improvements, some cancers are still untreatable. Recently there has been an increasing interest in the use of natural substances for cancer prevention and treatment. Hibiscus sabdariffa (HS) is a plant, belonging to Malvaceae family, widespread in South Asia and Central Africa. HS extract (HSE) used in folk medicine, gained researchers' interest thanks to its antioxidant, anti-inflammatory, and chemopreventive properties. In the present study, we initially assessed HSE effect on a panel of human tumor cell lines. Then we focused our study on the following that are most sensitive to HSE action cell lines: Multiple Myeloma (MM) cells (RPMI 8226) and Oral Squamous Cell Carcinoma (OSCC) cells (SCC-25). In both RPMI 8226 and SCC-25 cells, HSE impaired cell growth, exerted a reversible cytostatic effect, and reduced cell motility and invasiveness. We evaluated the involvement of MAPKs ERK1/2 and p38 in HSE effects by using specific inhibitors, U0126 and SB203580, respectively. For both SCC-25 and RPMI 8226, HSE cytostatic effect depends on p38 activation, whereas ERK1/2 modulation is crucial for cell motility and invasiveness. Our results suggest that HSE may be a potential therapeutic agent against MM and OSCC.

  11. Validity of Hydrostatic Equilibrium in Galaxy Clusters from Cosmological Hydrodynamical Simulations

    NASA Astrophysics Data System (ADS)

    Suto, Daichi; Kawahara, Hajime; Kitayama, Tetsu; Sasaki, Shin; Suto, Yasushi; Cen, Renyue

    2013-04-01

    We examine the validity of the hydrostatic equilibrium (HSE) assumption for galaxy clusters using one of the highest-resolution cosmological hydrodynamical simulations. We define and evaluate several effective mass terms corresponding to the Euler equations of gas dynamics, and quantify the degree of the validity of HSE in terms of the mass estimate. We find that the mass estimated under the HSE assumption (the HSE mass) deviates from the true mass by up to ~30%. This level of departure from HSE is consistent with the previous claims, but our physical interpretation is rather different. We demonstrate that the inertial term in the Euler equations makes a negligible contribution to the total mass, and the overall gravity of the cluster is balanced by the thermal gas pressure gradient and the gas acceleration term. Indeed, the deviation from the HSE mass is well explained by the acceleration term at almost all radii. We also clarify the confusion of previous work due to the inappropriate application of the Jeans equations in considering the validity of HSE from the gas dynamics extracted from cosmological hydrodynamical simulations.

  12. Efficient hybrid density functional calculations in solids: assessment of the Heyd-Scuseria-Ernzerhof screened Coulomb hybrid functional.

    PubMed

    Heyd, Jochen; Scuseria, Gustavo E

    2004-07-15

    The present work introduces an efficient screening technique to take advantage of the fast spatial decay of the short range Hartree-Fock (HF) exchange used in the Heyd-Scuseria-Ernzerhof (HSE) screened Coulomb hybrid density functional. The screened HF exchange decay properties and screening efficiency are compared with traditional hybrid functional calculations on solids. The HSE functional is then assessed using 21 metallic, semiconducting, and insulating solids. The examined properties include lattice constants, bulk moduli, and band gaps. The results obtained with HSE exhibit significantly smaller errors than pure density functional theory (DFT) calculations. For structural properties, the errors produced by HSE are up to 50% smaller than the errors of the local density approximation, PBE, and TPSS functionals used for comparison. When predicting band gaps of semiconductors, we found smaller errors with HSE, resulting in a mean absolute error of 0.2 eV (1.3 eV error for all pure DFT functionals). In addition, we present timing results which show the computational time requirements of HSE to be only a factor of 2-4 higher than pure DFT functionals. These results make HSE an attractive choice for calculations of all types of solids. (c) 2004 American Institute of Physics.

  13. Osmium isotope and highly siderophile element systematics of the lunar crust

    USGS Publications Warehouse

    Day, J.M.D.; Walker, R.J.; James, O.B.; Puchtel, I.S.

    2010-01-01

    Coupled 187Os/188Os and highly siderophile element (HSE: Os, Ir, Ru, Pt, Pd, and Re) abundance data are reported for pristine lunar crustal rocks 60025, 62255, 65315 (ferroan anorthosites, FAN) and 76535, 78235, 77215 and a norite clast in 15455 (magnesian-suite rocks, MGS). Osmium isotopes permit more refined discrimination than previously possible of samples that have been contaminated by meteoritic additions and the new results show that some rocks, previously identified as pristine, contain meteorite-derived HSE. Low HSE abundances in FAN and MGS rocks are consistent with derivation from a strongly HSE-depleted lunar mantle. At the time of formation, the lunar floatation crust, represented by FAN, had 1.4 ?? 0.3 pg g- 1 Os, 1.5 ?? 0.6 pg g- 1 Ir, 6.8 ?? 2.7 pg g- 1 Ru, 16 ?? 15 pg g- 1 Pt, 33 ?? 30 pg g- 1 Pd and 0.29 ?? 0.10 pg g- 1 Re (??? 0.00002 ?? CI) and Re/Os ratios that were modestly elevated (187Re/188Os = 0.6 to 1.7) relative to CI chondrites. MGS samples are, on average, characterised by more elevated HSE abundances (??? 0.00007 ?? CI) compared with FAN. This either reflects contrasting mantle-source HSE characteristics of FAN and MGS rocks, or different mantle-crust HSE fractionation behaviour during production of these lithologies. Previous studies of lunar impact-melt rocks have identified possible elevated Ru and Pd in lunar crustal target rocks. The new results provide no supporting evidence for such enrichments. If maximum estimates for HSE in the lunar mantle are compared with FAN and MGS averages, crust-mantle concentration ratios (D-values) must be ??? 0.3. Such D-values are broadly similar to those estimated for partitioning between the terrestrial crust and upper mantle, with the notable exception of Re. Given the presumably completely different mode of origin for the primary lunar floatation crust and tertiary terrestrial continental crust, the potential similarities in crust-mantle HSE partitioning for the Earth and Moon are somewhat

  14. Separation of Y-chromosomal haplotypes from male DNA mixtures via multiplex haplotype-specific extraction.

    PubMed

    Rothe, Jessica; Nagy, Marion

    2015-11-01

    In forensic analysis, the interpretation of DNA mixtures is the subject of ongoing debate and requires expertise knowledge. Haplotype-specific extraction (HSE) is an alternative method that enables the separation of large chromosome fragments or haplotypes by using magnetic beads in conjunction with allele-specific probes. HSE thus allows physical separation of the components of a DNA mixture. Here, we present the first multiplex HSE separation of a Y-chromosomal haplotype consisting of six Yfiler short tandem repeat markers from a mixture of male DNA.

  15. Cerebrospinal fluid cyto-/chemokine profile during acute herpes simplex virus induced anti-N-methyl-d-aspartate receptor encephalitis and in chronic neurological sequelae.

    PubMed

    Kothur, Kavitha; Gill, Deepak; Wong, Melanie; Mohammad, Shekeeb S; Bandodkar, Sushil; Arbunckle, Susan; Wienholt, Louise; Dale, Russell C

    2017-08-01

    To examine the cytokine/chemokine profile of cerebrospinal fluid (CSF) during acute herpes simplex virus-induced N-methyl-d-aspartate receptor (NMDAR) autoimmunity and in chronic/relapsing post-herpes simplex virus encephalitis (HSE) neurological syndromes. We measured longitudinal serial CSF cyto-/chemokines (n=34) and a glial marker (calcium-binding astroglial protein, S100B) in one patient during acute HSE and subsequent anti-NMDAR encephalitis, and compared the results with those from two patients with anti-NMDAR encephalitis without preceding HSE. We also compared cyto-/chemokines in cross-sectional CSF samples from three children with previous HSE who had ongoing chronic or relapsing neurological symptoms (2yr 9 mo-16y after HSE) with those in a group of children having non-inflammatory neurological conditions (n=20). Acute HSE showed elevation of a broad range of all T-helper-subset-related cyto-/chemokines and S100B whereas the post-HSE anti-NMDAR encephalitis phase showed persistent elevation of two of five T-helper-1 (chemokine [C-X-C motif] ligand 9 [CXCL9], CXCL10), three of five predominantly B-cell (CXCL13, CCL19, a proliferation-inducing ligand [APRIL])-mediated cyto-/chemokines, and interferon-α. The post-HSE anti-NMDAR encephalitis inflammatory response was more pronounced than anti-NMDAR encephalitis. All three chronic post-HSE cases showed persistent elevation of CXCL9, CXCL10, and interferon-α, and there was histopathological evidence of chronic lymphocytic inflammation in one biopsied case 7 years after HSE. Two of three chronic cases showed a modest response to immune therapy. HSE-induced anti-NMDAR encephalitis is a complex and pronounced inflammatory syndrome. There is persistent CSF upregulation of cyto-/chemokines in chronic or relapsing post-HSE neurological symptoms, which may be modifiable with immune therapy. The elevated cyto-/chemokines may be targets of monoclonal therapies. © 2017 Mac Keith Press.

  16. Osmium isotope and highly siderophile element systematics of the lunar crust

    NASA Astrophysics Data System (ADS)

    Day, James M. D.; Walker, Richard J.; James, Odette B.; Puchtel, Igor S.

    2010-01-01

    Coupled 187Os/ 188Os and highly siderophile element (HSE: Os, Ir, Ru, Pt, Pd, and Re) abundance data are reported for pristine lunar crustal rocks 60025, 62255, 65315 (ferroan anorthosites, FAN) and 76535, 78235, 77215 and a norite clast in 15455 (magnesian-suite rocks, MGS). Osmium isotopes permit more refined discrimination than previously possible of samples that have been contaminated by meteoritic additions and the new results show that some rocks, previously identified as pristine, contain meteorite-derived HSE. Low HSE abundances in FAN and MGS rocks are consistent with derivation from a strongly HSE-depleted lunar mantle. At the time of formation, the lunar floatation crust, represented by FAN, had 1.4 ± 0.3 pg g - 1 Os, 1.5 ± 0.6 pg g - 1 Ir, 6.8 ± 2.7 pg g - 1 Ru, 16 ± 15 pg g - 1 Pt, 33 ± 30 pg g - 1 Pd and 0.29 ± 0.10 pg g - 1 Re (˜ 0.00002 × CI) and Re/Os ratios that were modestly elevated ( 187Re/ 188Os = 0.6 to 1.7) relative to CI chondrites. MGS samples are, on average, characterised by more elevated HSE abundances (˜ 0.00007 × CI) compared with FAN. This either reflects contrasting mantle-source HSE characteristics of FAN and MGS rocks, or different mantle-crust HSE fractionation behaviour during production of these lithologies. Previous studies of lunar impact-melt rocks have identified possible elevated Ru and Pd in lunar crustal target rocks. The new results provide no supporting evidence for such enrichments. If maximum estimates for HSE in the lunar mantle are compared with FAN and MGS averages, crust-mantle concentration ratios ( D-values) must be ≤ 0.3. Such D-values are broadly similar to those estimated for partitioning between the terrestrial crust and upper mantle, with the notable exception of Re. Given the presumably completely different mode of origin for the primary lunar floatation crust and tertiary terrestrial continental crust, the potential similarities in crust-mantle HSE partitioning for the Earth and Moon are

  17. Photoprotection by pistachio bioactives in a 3-dimensional human skin equivalent tissue model.

    PubMed

    Chen, C-Y Oliver; Smith, Avi; Liu, Yuntao; Du, Peng; Blumberg, Jeffrey B; Garlick, Jonathan

    2017-01-25

    Reactive oxygen species (ROS) generated during ultraviolet (UV) light exposure can induce skin damage and aging. Antioxidants can provide protection against oxidative injury to skin via "quenching" ROS. Using a validated 3-dimensional (3D) human skin equivalent (HSE) tissue model that closely mimics human skin, we examined whether pistachio antioxidants could protect HSE against UVA-induced damage. Lutein and γ-tocopherol are the predominant lipophilic antioxidants in pistachios; treatment with these compounds prior to UVA exposure protected against morphological changes to the epithelial and connective tissue compartments of HSE. Pistachio antioxidants preserved overall skin thickness and organization, as well as fibroblast morphology, in HSE exposed to UVA irradiation. However, this protection was not substantiated by the analysis of the proliferation of keratinocytes and apoptosis of fibroblasts. Additional studies are warranted to elucidate the basis of these discordant results and extend research into the potential role of pistachio bioactives promoting skin health.

  18. Acute and prolonged complement activation in the central nervous system during herpes simplex encephalitis.

    PubMed

    Eriksson, Charlotta E; Studahl, Marie; Bergström, Tomas

    2016-06-15

    Herpes simplex encephalitis (HSE) is characterized by a pronounced inflammatory activity in the central nervous system (CNS). Here, we investigated the acute and prolonged complement system activity in HSE patients, by using enzyme-linked immunosorbent assays (ELISAs) for numerous complement components (C). We found increased cerebrospinal fluid concentrations of C3a, C3b, C5 and C5a in HSE patients compared with healthy controls. C3a and C5a concentrations remained increased also compared with patient controls. Our results conclude that the complement system is activated in CNS during HSE in the acute phase, and interestingly also in later stages supporting previous reports of prolonged inflammation. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. Herpes Simplex Encephalitis of the Parietal Lobe: A Rare Presentation.

    PubMed

    Fisahn, Christian; Tkachenko, Lara; Moisi, Marc; Rostad, Steven; Umeh, Randle; Zwillman, Michael E; Tubbs, R Shane; Page, Jeni; Newell, David W; Delashaw, Johnny B

    2016-09-16

    A 69-year-old female with a history of breast cancer and hypertension presented with a rare case of herpes simplex encephalitis (HSE) isolated to her left parietal lobe. The patient's first biopsy was negative for herpes simplex virus (HSV) I/II antigens, but less than two weeks later, the patient tested positive on repeat biopsy. This initial failure to detect the virus and the similarities between HSE and symptoms of intracranial hemorrhage (ICH) suggests repeat testing for HSV in the presence of ICH. Due to the frequency of patients with extra temporal HSE, a diagnosis of HSE should be more readily considered, particularly when a patient may not be improving and a concrete diagnosis has not been solidified.

  20. Platinum Partitioning at Low Oxygen Fugacity: Implications for Core Formation Processes

    NASA Technical Reports Server (NTRS)

    Medard, E.; Martin, A. M.; Righter, K.; Lanziroti, A.; Newville, M.

    2016-01-01

    Highly siderophile elements (HSE = Au, Re, and the Pt-group elements) are tracers of silicate / metal interactions during planetary processes. Since most core-formation models involve some state of equilibrium between liquid silicate and liquid metal, understanding the partioning of highly siderophile elements (HSE) between silicate and metallic melts is a key issue for models of core / mantle equilibria and for core formation scenarios. However, partitioning models for HSE are still inaccurate due to the lack of sufficient experimental constraints to describe the variations of partitioning with key variable like temperature, pressure, and oxygen fugacity. In this abstract, we describe a self-consistent set of experiments aimed at determining the valence of platinum, one of the HSE, in silicate melts. This is a key information required to parameterize the evolution of platinum partitioning with oxygen fugacity.

  1. Do people with low self-esteem really want to feel better? Self-esteem differences in motivation to repair negative moods.

    PubMed

    Heimpel, Sara A; Wood, Joanne V; Marshall, Margaret A; Brown, Jonathon D

    2002-01-01

    This research examined the hypothesis that people with low self-esteem (LSE) are less motivated than people with high self-esteem (HSE) to repair their negative moods. In Study 1, participants completed diaries in response to either a success or a failure in their everyday lives. Participants described what they intended to do next and the reasons behind those plans. After failure, fewer LSE than HSE participants expressed a goal to improve their mood. A follow-up investigation (Study 2) suggested that this difference was not due to a self-esteem difference in knowledge of mood repair strategies. In Study 3, after undergoing a negative mood induction, fewer LSE than HSE participants chose to watch a comedy video, even though both groups believed the comedy video would make them happy. Studies 4 and 5 explored possible reasons why LSE people are less motivated than HSE people to repair their negative moods.

  2. The formation of nuggets of highly siderophile elements in quenched silicate melts at high temperatures: Before or during the silicate quench?

    NASA Astrophysics Data System (ADS)

    Malavergne, V.; Charon, E.; Jones, J.; Cordier, P.; Righter, K.; Deldicque, D.; Hennet, L.

    2016-01-01

    The Highly Siderophile Elements (HSE) are powerful tracers of planetary differentiation. Despite the importance of their partitioning between silicate and metal for the understanding of planetary core formation, especially for the Earth and Mars, there is still a huge discrepancy between conclusions based on different high temperature (HT) experimental studies. These disagreements may be due to the presence of HSE micro and nanonuggets in HT experiments. The formation of these nuggets is still interpreted in different ways. One hypothesis is that these HSE nuggets formed during the quench of the silicate melt, while another hypothesis supposes that these nuggets formed before the quench and represented artefacts of HT experiments. The goal of this work is to clarify whether the presence of HSE nuggets in silicate melts is linked to a quench effect or not. Understanding the formation of these HSE nuggets represents thus a necessary step towards the resolution of the Earth's core formation scenarios. We performed new HT experiments (1275-2000 °C) at different oxygen fugacities (fO2), between ambient air up to ∼5 log units below the Iron-Wüstite buffer [IW-5], for two different silicate compositions (synthetic martian and terrestrial basalts) mixed with a metallic mixture of Pt-Au-Pd-Ru. Our 1275-1600 °C experiments were contained in either olivine, diopside or graphite crucible; experiments at 2000 °C were performed using a levitation method, so no capsule was necessary. Our samples contained quenched silicate melts, minerals (olivine, pyroxene, spinel depending on the run), a two-phase metallic bead and nano and micro-nuggets of HSE. Our samples underwent fine textural, structural and analytical characterizations. The distribution of the nuggets was not homogeneous throughout the quenched silicate melt. HSE nuggets were present within crystals. Dendritic textures from the quenched silicate melt formed around HSE nuggets, which could be crystallized, showing

  3. Highly siderophile elements in chondrites

    USGS Publications Warehouse

    Horan, M.F.; Walker, R.J.; Morgan, J.W.; Grossman, J.N.; Rubin, A.E.

    2003-01-01

    The abundances of the highly siderophile elements (HSE), Re, Os, Ir, Ru, Pt and Pd, were determined by isotope dilution mass spectrometry for bulk samples of 13 carbonaceous chondrites, 13 ordinary chondrites and 9 enstatite chondrites. These data are coupled with corresponding 187Re-187Os isotopic data reported by Walker et al. [Geochim. Cosmochim. Acta, 2002] in order to constrain the nature and timing of chemical fractionation relating to these elements in the early solar system. The suite of chondrites examined displays considerable variations in absolute abundances of the HSE, and in the ratios of certain HSE. Absolute abundances of the HSE vary by nearly a factor of 80 among the chondrite groups, although most vary within a factor of only 2. Variations in concentration largely reflect heterogeneities in the sample aliquants. Different aliquants of the same chondrite may contain variable proportions of metal and/or refractory inclusions that are HSE-rich, and sulfides that are HSE-poor. The relatively low concentrations of the HSE in CI1 chondrites likely reflect dilution by the presence of volatile components. Carbonaceous chondrites have Re/Os ratios that are, on average, approximately 8% lower than ratios for ordinary and enstatite chondrites. This is also reflected in 187Os/188Os ratios that are approximately 3% lower for carbonaceous chondrites than for ordinary and enstatite chondrites. Given the similarly refractory natures of Re and Os, this fractionation may have occurred within a narrow range of high temperatures, during condensation of these elements from the solar nebula. Superimposed on this major fractionation are more modest movements of Re or Os that occurred within the last 0-2 Ga, as indicated by minor open-system behavior of the Re-Os isotope systematics of some chondrites. The relative abundances of other HSE can also be used to discriminate among the major classes of chondrites. For example, in comparison to the enstatite chondrites

  4. Use of clinical and neuroimaging characteristics to distinguish temporal lobe herpes simplex encephalitis from its mimics.

    PubMed

    Chow, Felicia C; Glaser, Carol A; Sheriff, Heather; Xia, Dongxiang; Messenger, Sharon; Whitley, Richard; Venkatesan, Arun

    2015-05-01

    We describe the spectrum of etiologies associated with temporal lobe (TL) encephalitis and identify clinical and radiologic features that distinguish herpes simplex encephalitis (HSE) from its mimics. We reviewed all adult cases of encephalitis with TL abnormalities on magnetic resonance imaging (MRI) from the California Encephalitis Project. We evaluated the association between specific clinical and MRI characteristics and HSE compared with other causes of TL encephalitis and used multivariate logistic modeling to identify radiologic predictors of HSE. Of 251 cases of TL encephalitis, 43% had an infectious etiology compared with 16% with a noninfectious etiology. Of infectious etiologies, herpes simplex virus was the most commonly identified agent (n = 60), followed by tuberculosis (n = 8) and varicella zoster virus (n = 7). Of noninfectious etiologies, more than half (n = 21) were due to autoimmune disease. Patients with HSE were older (56.8 vs 50.2 years; P = .012), more likely to be white (53% vs 35%; P = .013), more likely to present acutely (88% vs 64%; P = .001) and with a fever (80% vs 49%; P < .001), and less likely to present with a rash (2% vs 15%; P = .010). In a multivariate model, bilateral TL involvement (odds ratio [OR], 0.38; 95% confidence interval [CI], .18-.79; P = .010) and lesions outside the TL, insula, or cingulate (OR, 0.37; 95% CI, .18-.74; P = .005) were associated with lower odds of HSE. In addition to HSE, other infectious and noninfectious etiologies should be considered in the differential diagnosis for TL encephalitis, depending on the presentation. Specific clinical and imaging features may aid in distinguishing HSE from non-HSE causes of TL encephalitis. © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  5. Use of Clinical and Neuroimaging Characteristics to Distinguish Temporal Lobe Herpes Simplex Encephalitis From Its Mimics

    PubMed Central

    Chow, Felicia C.; Glaser, Carol A.; Sheriff, Heather; Xia, Dongxiang; Messenger, Sharon; Whitley, Richard; Venkatesan, Arun

    2015-01-01

    Background. We describe the spectrum of etiologies associated with temporal lobe (TL) encephalitis and identify clinical and radiologic features that distinguish herpes simplex encephalitis (HSE) from its mimics. Methods. We reviewed all adult cases of encephalitis with TL abnormalities on magnetic resonance imaging (MRI) from the California Encephalitis Project. We evaluated the association between specific clinical and MRI characteristics and HSE compared with other causes of TL encephalitis and used multivariate logistic modeling to identify radiologic predictors of HSE. Results. Of 251 cases of TL encephalitis, 43% had an infectious etiology compared with 16% with a noninfectious etiology. Of infectious etiologies, herpes simplex virus was the most commonly identified agent (n = 60), followed by tuberculosis (n = 8) and varicella zoster virus (n = 7). Of noninfectious etiologies, more than half (n = 21) were due to autoimmune disease. Patients with HSE were older (56.8 vs 50.2 years; P = .012), more likely to be white (53% vs 35%; P = .013), more likely to present acutely (88% vs 64%; P = .001) and with a fever (80% vs 49%; P < .001), and less likely to present with a rash (2% vs 15%; P = .010). In a multivariate model, bilateral TL involvement (odds ratio [OR], 0.38; 95% confidence interval [CI], .18–.79; P = .010) and lesions outside the TL, insula, or cingulate (OR, 0.37; 95% CI, .18–.74; P = .005) were associated with lower odds of HSE. Conclusions. In addition to HSE, other infectious and noninfectious etiologies should be considered in the differential diagnosis for TL encephalitis, depending on the presentation. Specific clinical and imaging features may aid in distinguishing HSE from non-HSE causes of TL encephalitis. PMID:25637586

  6. Mesoarchean melting and Neoarchean to Paleoproterozoic metasomatism during the formation of the cratonic mantle keel beneath West Greenland

    NASA Astrophysics Data System (ADS)

    van Acken, D.; Luguet, A.; Pearson, D. G.; Nowell, G. M.; Fonseca, R. O. C.; Nagel, T. J.; Schulz, T.

    2017-04-01

    Highly siderophile element (HSE) concentration and 187Os/188Os isotopic heterogeneity has been observed on various scales in the Earth's mantle. Interaction of residual mantle peridotite with infiltrating melts has been suggested to overprint primary bulk rock HSE signatures originating from partial melting, contributing to the heterogeneity seen in the global peridotite database. Here we present a detailed study of harzburgitic xenolith 474527 from the Kangerlussuaq suite, West Greenland, coupling the Re-Os isotope geochemistry with petrography of both base metal sulfides (BMS) and silicates to assess the impact of overprint induced by melt-rock reaction on the Re-Os isotope system. Garnet harzburgite sample 474527 shows considerable heterogeneity in the composition of its major phases, most notably olivine and Cr-rich garnet, suggesting formation through multiple stages of partial melting and subsequent metasomatic events. The major BMS phases show a fairly homogeneous pentlandite-rich composition typical for BMS formed via metasomatic reaction, whereas the 187Os/188Os compositions determined for 17 of these BMS are extremely heterogeneous ranging between 0.1037 and 0.1981. Analyses by LA-ICP-MS reveal at least two populations of BMS grains characterized by contrasting HSE patterns. One type of pattern is strongly enriched in the more compatible HSE Os, Ir, and Ru over the typically incompatible Pt, Pd, and Re, while the other type shows moderate enrichment of the more incompatible HSE and has overall lower compatible HSE/incompatible HSE composition. The small-scale heterogeneity observed in these BMS highlights the need for caution when utilizing the Re-Os system to date mantle events, as even depleted harzburgite samples such as 474527 are likely to have experienced a complex history of metasomatic overprinting, with uncertain effects on the HSE.

  7. Temporal and pontine involvement in a case of herpes simplex encephalitis, presenting as kluver bucy syndrome - a case report.

    PubMed

    Thirunavukarasu, Suresh

    2011-01-01

    Bilateral temporal and frontal lobe involvement is a common characteristic of herpes simplex encephalitis (HSE). Clinical sequelae of herpes simplex encephalitis may manifest sometimes as Kluver Bucy syndrome (KBS). In herpes simplex encephalitis, apart from frontal lobe, extra temporal involvement is rare and uncommon. We report a case of HSE manifesting clinically as KBS with a rare radiological finding of temporal and extratemporal involvement of pons.

  8. Diffusion-weighted imaging and apparent diffusion coefficient evaluation of herpes simplex encephalitis and Japanese encephalitis.

    PubMed

    Sawlani, Vijay

    2009-12-15

    The aim of the study was to evaluate (a) the role of diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) values in differentiating necrotising herpes simplex encephalitis (HSE) and non-necrotising Japanese encephalitis (JE) and (b) to correlate the ADC values with the duration of illness. Forty-five confirmed cases of encephalitis (38 patients with JE and 7 patients with HSE) underwent MR imaging. IgM antibody capture enzyme-linked immunosorbent assay (IgM MAC-ELISA) and polymerase chain reaction (PCR) tests were performed in cerebral spinal fluid (CSF) sample to confirm the diagnosis of JE and HSE respectively. MRI findings were recorded in terms of site of involvement, extent of lesions, visibility of each lesion on T2W, DWI and FLAIR sequences and ADC calculations. To observe the changes in ADC with duration of illness, patients with JE and HSE were regrouped on the basis of time since clinical presentation. Mean of the ADC value in each patient was noted and subjected for statistical analysis. In HSE lesions there was a significant restricted diffusion with low average ADC values observed in acute stage and facilitated diffusion with high average ADC values observed in chronic stage. Whereas JE lesions did not show restricted diffusion and significant low ADC values in acute stage, though facilitated diffusion and high ADC values were observed in chronic stage. The diffusion abnormality and conspicuity of lesions on DWI may be different in various acute encephalitis (HSE and JE). The ADC values are different in the acute stages of HSE and JE reflecting the difference in the degree of diffusability of water molecule. These observations may suggest that there may be an abundance of cytotoxic oedema in HSE and paucity of cytotoxic oedema in JE, in acute stage.

  9. Hwanggeumchal sorghum Induces Cell Cycle Arrest, and Suppresses Tumor Growth and Metastasis through Jak2/STAT Pathways in Breast Cancer Xenografts

    PubMed Central

    Lim, Eun Joung; Joung, Youn Hee; Hong, Dae Young; Park, Eui U.; Park, Seung Hwa; Choi, Soo Keun; Moon, Eon-Soo; Cho, Byung Wook; Park, Kyung Do; Lee, Hak Kyo; Kim, Myong-Jo; Park, Dong-Sik; Yang, Young Mok

    2012-01-01

    Background Cancer is one of the highly virulent diseases known to humankind with a high mortality rate. Breast cancer is the most common cancer in women worldwide. Sorghum is a principal cereal food in many parts of the world, and is critical in folk medicine of Asia and Africa. In the present study, we analyzed the effects of HSE in metastatic breast cancer. Methodology/Principal Findings Preliminary studies conducted on MDA-MB 231 and MCF-7 xenograft models showed tumor growth suppression by HSE. Western blotting studies conducted both in vivo and in vitro to check the effect of HSE in Jak/STAT pathways. Anti-metastatic effects of HSE were confirmed using both MDA-MB 231 and MCF-7 metastatic animal models. These studies showed that HSE can modulate Jak/STAT pathways, and it hindered the STAT5b/IGF-1R and STAT3/VEGF pathways not only by down-regulating the expression of these signal molecules and but also by preventing their phosphorylation. The expression of angiogenic factors like VEGF, VEGF-R2 and cell cycle regulators like cyclin D, cyclin E, and pRb were found down-regulated by HSE. In addition, it also targets Brk, p53, and HIF-1α for anti-cancer effects. HSE induced G1 phase arrest and migration inhibition in MDA-MB 231 cells. The metastasis of breast cancer to the lungs also found blocked by HSE in the metastatic animal model. Conclusions/Significance Usage of HS as a dietary supplement is an inexpensive natural cancer therapy, without any side effects. We strongly recommend the use of HS as an edible therapeutic agent as it possesses tumor suppression, migration inhibition, and anti-metastatic effects on breast cancer. PMID:22792362

  10. Fifteen minute consultation: Managing neonatal and childhood herpes encephalitis

    PubMed Central

    Le Doare, K; Menson, Esse; Patel, Deepak; Lim, Ming; Lyall, Hermione; Herberg, Jethro

    2015-01-01

    Herpes simplex encephalitis (HSE) is the most common single cause of viral encephalitis in infants and children. Treated or untreated, it can be associated with considerable morbidity and mortality, and its presentation is usually insidious and non-specific. Prompt and careful investigation is important in order to establish the diagnosis so that treatment can be optimised. We address some common questions arising when diagnosing and treating presumed HSE throughout childhood. PMID:25112286

  11. Low Abundances of Highly Siderophile Elements in the Lunar Mantle: Evidence for Prolonged Late Accretion

    NASA Technical Reports Server (NTRS)

    Walker, R. J.; Horan, M. F.; Shearer, C. K.; Papike, J. J.

    2004-01-01

    The highly siderophile elements (HSE: including Re, Au, Ir, Os, Ru, Pt, Pd, Rh) are strongly partitioned into metal relative to silicates. In the terrestrial planets these elements are concentrated in metallic cores. Earth s mantle has sufficiently high abundances of the HSE (0.008 times CI abundances) that it has been hypothesized approximately 0.1-0.5% of the mass of the Earth was added following the last major interaction between the core and mantle [e.g. 1]. The additional material added to the Earth and Moon has been termed a late veneer , and the process has often been termed late accretion [2]. The timing of the dominant late accretionary period of the Earth and Moon is still poorly known. The abundances of HSE in the lunar mantle could provide important constraints on when the late veneer was added. The material that ultimately became the silicate portion of the Moon was likely stripped of most of its HSE prior to and during coalescence of the Moon. Consequently the initial lunar mantle likely had very low concentrations of the HSE. Unlike Earth, the generation of permanent lunar crust by 4.4 Ga prevented subsequent additions of HSE to the lunar mantle via continued accretion. Thus, if a substantial portion of the late veneer was added after 4.4 Ga, the lunar mantle should have retained very low HSE concentrations. Conversely, if the late veneer was mostly added prior to 4.4 Ga, HSE abundances in the lunar mantle may be roughly similar to abundances in the terrestrial mantle.

  12. IMACS 󈨟: Proceedings of the IMACS World Congress on Computation and Applied Mathematics (13th) Held in Dublin, Ireland on July 22-26, 1991. Volume 2. Computational Fluid Dynamics and Wave Propagation, Parallel Computing, Concurrent and Supercomputing, Computational Physics/Computational Chemistry and Evolutionary Systems

    DTIC Science & Technology

    1991-01-01

    difference schemes does not lead to erroneous solutions where the electric field E, the hole current density 3 and the electron (although accuracy could...in th:s systeni remark that, Lecause vf the behaviour of the elecL.ic field, the equa- are the electric potential ip, the hole concentration p and the...be applied convenient to rewrite the system (1)-(6) into other variables. First of to the discretisation of these cquations. all, the electric

  13. Test and demonstration of a 1-MW wellhead generator: helical screw expander power plant, Model 76-1. Final report to the International Energy Agency

    SciTech Connect

    Not Available

    1985-07-04

    A 1-MW geothermal wellhead power plant incorporating a Lysholm or helical screw expander (HSE) was field tested between 1980 and 1983 by Mexico, Italy, and New Zealand with technical assistance from the United States. The objectives were to provide data on the reliability and performance of the HSE and to assess the costs and benefits of its use. The range of conditions under which the HSE was tested included loads up to 933 kW, mass flowrates of 14,600 to 395, 000 lbs/hr, inlet pressures of 64 to 220 psia, inlet qualities of 0 to 100%, exhaust pressures of 3.1 to 40 psia, total dissolved solids up to 310,000 ppM, and noncondensible gases up to 38% of the vapor mass flow. Typical machine efficiencies of 40 to 50% were calculated. For most operations efficiency increased approximately logarithmically with shaft power, while inlet quality and rotor speed had only small effects. The HSE was designed with oversized internal clearances in the expectation that adherent scale would form during operation. Improvements in machine efficiency of 3.5 to 4 percentage points were observed over some test periods with some scale deposition. A comparison with a 1-MW back-pressure turbine showed that the HSE can compete favorably under certain conditions. The HSE was found to be a rugged energy conversion machine for geothermal applications, but some subsystems were found to require further development. 7 refs., 28 figs., 5 tabs.

  14. A density functional theory investigation of the electronic structure and spin moments of magnetite.

    PubMed

    Noh, Junghyun; Osman, Osman I; Aziz, Saadullah G; Winget, Paul; Brédas, Jean-Luc

    2014-08-01

    We present the results of density functional theory (DFT) calculations on magnetite, Fe3O4, which has been recently considered as electrode in the emerging field of organic spintronics. Given the nature of the potential applications, we evaluated the magnetite room-temperature cubic [Formula: see text] phase in terms of structural, electronic, and magnetic properties. We considered GGA (PBE), GGA + U (PBE + U), and range-separated hybrid (HSE06 and HSE(15%)) functionals. Calculations using HSE06 and HSE(15%) functionals underline the impact that inclusion of exact exchange has on the electronic structure. While the modulation of the band gap with exact exchange has been seen in numerous situations, the dramatic change in the valence band nature and states near the Fermi level has major implications for even a qualitative interpretation of the DFT results. We find that HSE06 leads to highly localized states below the Fermi level while HSE(15%) and PBE + U result in delocalized states around the Fermi level. The significant differences in local magnetic moments and atomic charges indicate that describing room-temperature bulk materials, surfaces and interfaces may require different functionals than their low-temperature counterparts.

  15. A density functional theory investigation of the electronic structure and spin moments of magnetite

    PubMed Central

    Noh, Junghyun; Osman, Osman I; Aziz, Saadullah G; Winget, Paul; Brédas, Jean-Luc

    2014-01-01

    We present the results of density functional theory (DFT) calculations on magnetite, Fe3O4, which has been recently considered as electrode in the emerging field of organic spintronics. Given the nature of the potential applications, we evaluated the magnetite room-temperature cubic phase in terms of structural, electronic, and magnetic properties. We considered GGA (PBE), GGA + U (PBE + U), and range-separated hybrid (HSE06 and HSE(15%)) functionals. Calculations using HSE06 and HSE(15%) functionals underline the impact that inclusion of exact exchange has on the electronic structure. While the modulation of the band gap with exact exchange has been seen in numerous situations, the dramatic change in the valence band nature and states near the Fermi level has major implications for even a qualitative interpretation of the DFT results. We find that HSE06 leads to highly localized states below the Fermi level while HSE(15%) and PBE + U result in delocalized states around the Fermi level. The significant differences in local magnetic moments and atomic charges indicate that describing room-temperature bulk materials, surfaces and interfaces may require different functionals than their low-temperature counterparts. PMID:27877697

  16. In-vitro vasodilatory activity of the hexanic extract of leaves and stems from Piper truncatum Vell. in rats.

    PubMed

    Raimundo, Juliana Montani; de Almeida, Roberta Ramos; Velozo, Leosvaldo Salazar Marques; Kaplan, Maria Auxiliadora Coelho; Gattass, Cerli Rocha; Zapata-Sudo, Gisele

    2004-11-01

    Several plants from the Brazilian Tropical Forest are used in folk medicine for treatment of hypertension and asthma. In this study, we investigated the effects of hexanic extracts of leaves (HLE) and stems (HSE) from Piper truncatum on the contractility of cardiac, vascular and tracheal smooth muscles. Twitches of cardiac muscles obtained with electrical stimulation were recorded before and after exposure to increasing concentrations of hexanic extracts. HLE and HSE respectively reduced significantly the amplitude of twitches to 57.05 +/- 11.63 and 61.58 +/- 5.70% of control in the presence of 100 microg mL(-1). Contractile response to a single concentration of adrenaline (epinephrine) was measured before and after exposure of rat aorta rings to HLE and HSE. Both extracts inhibited aorta contraction in a concentration-dependent manner. The concentration of 50% inhibitory effect (IC50) was 32.3 +/- 13.8 and 47.0 +/- 23.8 microg mL(-1) for HLE and HSE, respectively, in aorta with intact endothelium. HLE and HSE also reduced the acetylcholine-precontracted trachea in a concentration-dependent manner with maximal effect observed at 250 and 350 microg mL(-1), respectively. Vasodilatation and trachea relaxation induced by HLE and HSE could explain the use of Piper extracts to reduce blood pressure and bronchospasm.

  17. Permeability of the reconstructed human epidermis model Episkin in comparison to various human skin preparations.

    PubMed

    Netzlaff, Frank; Kaca, Monika; Bock, Udo; Haltner-Ukomadu, Eleonore; Meiers, Peter; Lehr, Claus-Michael; Schaefer, Ulrich F

    2007-04-01

    The objective of this work was to compare the barrier function of the small diameter reconstructed human epidermis model Episkin (d=12 mm) to human skin in vitro. For that purpose a modification for the Franz diffusion cell (d=15mm) had to be developed so as to allow direct comparison with the following human skin preparations: Full thickness skin (FTS), split thickness skin (STS), heat-separated epidermis (HSE), and trypsin isolated stratum corneum (TISC). Among the tested preparations, HSE appeared to be the most preferable due to its clear morphological structure and ease of preparation. The lipid profile of HSE and Episkin was analyzed and showed significant differences in terms of cholesterol, ceramides and triglycerides contents, whereas cholesterol esters and fatty acids were not different. Permeation data with HSE and Episkin were then gathered using caffeine and testosterone. Both test compounds permeated much faster through Episkin than through HSE. Moreover, opposed to Episkin, HSE differentiated between the two test compounds. In spite of the remarkable progress in developing RHEs in the past years at this time Episkin can obviously not yet fully replace human skin for in vitro permeability experiments.

  18. Charlo Wastewater Treatment Facility NPDES Permit

    EPA Pesticide Factsheets

    Under NPDES permit MT-0022551, the Consolidated Charlo-Lake County Water & Sewer District is authorized to discharge from its wastewater treatment facility located in Lake County, Montana to an unnamed swale that runs to Dublin Gulch.

  19. The demographic work of Sir William Wilde.

    PubMed

    Froggatt, P

    2016-05-01

    This paper argues that Sir William Wilde was indeed a pioneering demographer. It also describes the unveiling of the plaque commemorating Sir William Wilde at his home, 1, Merrion Square, Dublin on the 28 October 1971.

  20. Report to the U.S. Congress on the National Oceanographic Partnership Program

    DTIC Science & Technology

    2006-03-01

    Texas A&M University at Corpus Christi University College Dublin University of Georgia University of Vienna Max Planck...Institute Woods Hole Oceanographic Institution Monterey Bay Aquarium Research Institute Smithsonian Institution Station

  1. Jonathan Swift (1667-1745): master satirist, eccentric dean and frustrated lover.

    PubMed

    Carter, Richard

    2007-08-01

    Jonathan Swift, Irish author and poet, became an Anglican Dean with a macabre interest in medicine. He wrote 'Verses on the Death of Dr Swift' predicting how his death would be received in Dublin and London.

  2. 77 FR 46762 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-06

    ... Washington, DC; to acquire voting shares of Middlefield Banc Corp., and thereby indirectly acquire voting shares of The Middlefield Banking Company, both in Middlefield, Ohio, and Emerald Bank, Dublin; Ohio. B...

  3. Remediation System Evaluation, Former Honeywell Facility in Fort Washington, Pennsylvania

    EPA Pesticide Factsheets

    The Honeywell facility is located at 1100 Virginia Drive in Upper Dublin Township, Montgomery County, Pennsylvania in the Fort Washington Industrial Park. The property is approximately 67 acres and is owned by 1100 Virginia Drive Associates.

  4. 4. VIEW LOOKING ENE OF UNDERSIDE SHOWING RIBS AND BEAMS. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. VIEW LOOKING ENE OF UNDERSIDE SHOWING RIBS AND BEAMS. NOTE SPALLING ON NORTHERN EDGE AND EXPOSED REBAR. - Morris Run Bridge, Rickert Road (TR 417) spanning Morris Run in Hilltown Township, Dublin, Bucks County, PA

  5. Low prevalence of Salmonella in Swedish dairy herds highlight differences between serotypes.

    PubMed

    Ågren, Estelle C C; Sternberg Lewerin, Susanna; Wahlström, Helene; Emanuelson, Ulf; Frössling, Jenny

    2016-03-01

    Legislated Salmonella control in Sweden has been in place since the 1960s. The purpose of this study was to investigate presence of Salmonella antibodies in dairy cattle herds and to provide a basis for decisions on how surveillance and control can be improved. Bulk milk samples from all Swedish dairy herds (n=4 683) were analysed with two different ELISAs; one detecting antibodies against Salmonella Dublin (Dublin ELISA), and one detecting antibodies against several of the serotypes causing bovine salmonellosis including S. Dublin (Bovine ELISA). Information about herds, i.e. geographical location, local animal density, number of test positive herds within 5km, animal trade and herd size, was based on register data. The results confirm a very low prevalence of Salmonella in Swedish dairy herds throughout the country with the exception of an island in the southeast. The test positive herds split into two groups; 41 herds (1%) positive in the Dublin ELISA, and 101 herds (2%) positive in the Bovine ELISA but negative in the Dublin ELISA. Geographical location of positive herds, and comparison of the results of the screening with serotypes previously isolated from some of the herds, indicated that the first group represents herds presently or previously infected with S. Dublin while the second group represents herds presently or previously infected with other serotypes. Differences in serological status between herds in different regions, of different size, with different animal purchase patterns et cetera, were tested using logistic regression. Presence of positive herds within 5km was significantly associated to testing positive. For herds testing positive in the Dublin ELISA, significant associations were also seen with herd size. Purchase of animals during the last year was not significantly associated with the outcome in the final models. We conclude that for future surveillance, the Bovine ELISA can be used to help in identifying infected herds, and the Dublin

  6. Physical stratigraphy and hydrostratigraphy of Upper Cretaceous and Paleocene sediments, Burke and Screven Counties, Georgia

    USGS Publications Warehouse

    Falls, W.F.; Baum, J.S.; Prowell, D.C.

    1997-01-01

    Six geologic units are recognized in the Cretaceous and the Paleocene sediments of eastern Burke and Screven Counties in Georgia on the basis of lithologic, geophysical, and paleontologic data collected from three continuously cored testholes in Georgia and one testhole in South Carolina. The six geologic units are separated by regional unconformities and are designated from oldest to youngest as the Cape Fear Formation, the Middendorf Formation, the Black Creek Group (undivided), and the Steel Creek Formation in the Upper Cretaceous section, and the Ellenton and the Snapp Formations in the Paleocene section. The geologic units provide a spatial and temporal framework for the identification and correlation of a basal confining unit beneath the Midville aquifer system and five aquifers and five confining units in the Dublin and the Midville aquifer systems. The Dublin aquifer system is divided hydrostratigraphically into the Millers Pond, the upper Dublin, and the lower Dublin aquifers. The Midville aquifer system is divided hydrostratigraphically into the upper and the lower Midville aquifers. The fine-grained sediments of the Millers Pond, the lower Dublin, and the lower Midville confining units are nonmarine deposits and are present in the upper part of the Snapp Formation, the Black Creek Group (undivided), and the Middendorf Formation, respectively. Hydrologic data for specific sets of monitoring wells at the Savannah River Site in South Carolina and the Millers Pond site in Georgia confirm that these three units are leaky confining units and locally impede vertical ground-water flow between adjacent aquifers. The fine-grained sediments of the upper Dublin and the upper Midville confining units are marine-deltaic deposits of the Ellenton Formation and the Black Creek Group (undivided), respectively. Hydrologic data confirm that the upper Dublin confining unit regionally impedes vertical ground-water flow on both sides of the Savannah River. The upper Midville

  7. European Science Notes Information Bulletin Reports on Current European/ Middle Eastern Science

    DTIC Science & Technology

    1991-12-01

    Jan, Brest , France A New Technology Instrument System for the E. OMongain, Univ. Coll. Dublin, Dublin, Ireland; 353 1 837275 Measurement of the...Intelligent Marine D. Lebarbe and 0. Jan, Thomson Sintra, Brest , 33 98050465 Observations of Ocean Floor on Continental Shelves France; with J. Seniero, Lisbon...orbiting satellites. These sensors measure monomolecular films to disastrous spills, citing as electromagnetic radiation ( EMR ) either reflected or

  8. David Gordon Campbell Robertson: A Biographical Sketch

    NASA Astrophysics Data System (ADS)

    See, J. B.

    Emeritus Professor David Robertson of the Missouri University of Science and Technology was born in Dublin Ireland on 29 December 1941. His father was a merchant navy Captain who served during WWII and during David's early years his family lived in Dublin and Donegal where David went to the local elementary school. In 1954 he moved to London with his parents and attended Highgate School before commencing metallurgy at the Royal School of Mines, Imperial College, London in 1960.

  9. The Physics of Ultrabroadband Frequency Comb Generation and Optimized Combs for Measurements in Fundamental Physics

    DTIC Science & Technology

    2016-07-02

    Plenary Lecture at IEEE/ASME International Conference on Advanced Intelligent Mechatronics , July 8-11, Besançon, France (2014) J. M. Dudley...3School of Mathematical Sciences , University College Dublin, Belfield, Dublin 4, Ireland *Corresponding author: john.dudley@univ‑fcomte.fr Received...time stretching as described above. From the measured time series, it is straightfor- ward to compute the coefficient of variation Cv, which is plotted

  10. Asking about Sex in General Health Surveys: Comparing the Methods and Findings of the 2010 Health Survey for England with Those of the Third National Survey of Sexual Attitudes and Lifestyles.

    PubMed

    Prah, Philip; Johnson, Anne M; Nardone, Anthony; Clifton, Soazig; Mindell, Jennifer S; Copas, Andrew J; Robinson, Chloe; Craig, Rachel; Woodhall, Sarah C; Macdowall, Wendy; Fuller, Elizabeth; Erens, Bob; Sonnenberg, Pam; Wellings, Kaye; Mercer, Catherine H

    2015-01-01

    Including questions about sexual health in the annual Health Survey for England (HSE) provides opportunities for regular measurement of key public health indicators, augmenting Britain's decennial National Survey of Sexual Attitudes and Lifestyles (Natsal). However, contextual and methodological differences may limit comparability of the findings. We examine the extent of these differences between HSE 2010 and Natsal-3 and investigate their impact on parameter estimates. Complex survey analyses of data from men and women in the 2010 HSE (n = 2,782 men and 3,588 women) and Natsal-3 undertaken 2010-2012 (n = 4,882 men and 6,869 women) aged 16-69y and resident in England, both using probability sampling, compared their characteristics, the amount of non-response to, and estimates from, sexual health questions. Both surveys used self-completion for the sexual behaviour questions but this was via computer-assisted self-interview (CASI) in Natsal-3 and a pen-and-paper questionnaire in HSE 2010. The surveys achieved similar response rates, both around 60%, and demographic profiles largely consistent with the census, although HSE participants tended to be less educated, and reported worse general health, than Natsal-3 participants. Item non-response to the sexual health questions was typically higher in HSE 2010 (range: 9-18%) relative to Natsal-3 (all <5%). Prevalence estimates for sexual risk behaviours and STI-related indicators were generally slightly lower in HSE 2010 than Natsal-3. While a relatively high response to sexual health questions in HSE 2010 demonstrates the feasibility of asking such questions in a general health survey, differences with Natsal-3 do exist. These are likely due to the HSE's context as a general health survey and methodological limitations such as its current use of pen-and-paper questionnaires. Methodological developments to the HSE should be considered so that its data can be interpreted in combination with those from dedicated sexual

  11. Syntheses and structures of three f-element selenite/hydroselenite compounds

    SciTech Connect

    Burns, Wendy L.; Ibers, James A.

    2009-06-15

    The selenite/hydroselenite compounds Ce(SeO{sub 3})(HSeO{sub 3}), Tb(SeO{sub 3})(HSeO{sub 3}).2H{sub 2}O, and Cs[U(SeO{sub 3})(HSeO{sub 3})].3H{sub 2}O were synthesized by hydrothermal means at 453 K from the reaction of CeO{sub 2} or Tb{sub 4}O{sub 7} or UO{sub 2} with SeO{sub 2} and CsCl (as a mineralizer). Ce(SeO{sub 3})(HSeO{sub 3}) crystallizes in the non-centrosymmetric orthorhombic space group Pca2{sub 1}. The structure comprises a two-dimensional network of interconnected CeO{sub 10} bicapped distorted square antiprisms and SeO{sub 3} trigonal pyramids. Tb(SeO{sub 3})(HSeO{sub 3}).2H{sub 2}O crystallizes in the non-centrosymmetric orthorhombic space group P2{sub 1}2{sub 1}2{sub 1}. The structure features a two-dimensional layer of interconnected TbO{sub 8} distorted square antiprisms and SeO{sub 3} trigonal pyramids. Cs[U(SeO{sub 3})(HSeO{sub 3})].3H{sub 2}O crystallizes in the centrosymmetric monoclinic space group P2{sub 1}/n. The structure consists of two-dimensional layers of interconnected UO{sub 7} pentagonal bipyramids and SeO{sub 3} trigonal pyramids. The layers in all three structures are held together by hydrogen-bonding networks. - Graphical abstract: Structure of Ce[U(SeO{sub 3})(HSeO{sub 3})].3H{sub 2}O (Cs, purple; U, black; Se, blue; O, red; O{sub w}, green; H, gray).

  12. Validity of smoking prevalence estimates from primary care electronic health records compared with national population survey data for England, 2007 to 2011.

    PubMed

    Booth, Helen P; Prevost, A Toby; Gulliford, Martin C

    2013-12-01

    Primary care electronic health records (EHRs) are increasingly used as a resource for epidemiological research. Cigarette smoking is an important variable in many epidemiological studies. We evaluated the validity of smoking records in primary care EHRs by comparing estimates for smoking prevalence from primary care EHRs with national health survey data. Data were analysed for adults over 30 years of age from the Clinical Practice Research Datalink (CPRD) in comparison with data from the Health Survey for England between 2007 and 2011. Electronic health records in the CPRD were searched for records of smoking status and smoking cessation treatment. Annual age- and sex-standardised prevalence of current-, non- and former smoking were calculated, and compared with equivalent data from the Health Survey for England (HSE). The difference between estimates of current smoking in CPRD and HSE was generally <1% from 2007 to 2011. In 2011, the prevalence of current smoking in men was: CPRD 24.3%, HSE 24.2%. The mean difference was 0.1% (95% confidence interval −1.5 to 1.7%). In women, current smoking prevalence was CPRD 20.3%, HSE 19.0%; mean difference 1.3% (0.0 to 2.6%). Estimates for former smoking were lower in CPRD than HSE for men (CPRD 26.7%, HSE 31.3%) and women (CPRD 22.9%, HSE 25.0%). Prevalence estimates for current smoking, and non-smoking, from primary care EHRs are similar to those from nationally representative surveys, but former smoking may be under-recorded. © 2013 The Authors. Pharmacoepidemiology and Drug Safety published by John Wiley & Sons, Ltd.

  13. Formation of Apollo 16 impactites and the composition of late accreted material: Constraints from Os isotopes, highly siderophile elements and sulfur abundances

    NASA Astrophysics Data System (ADS)

    Gleißner, Philipp; Becker, Harry

    2017-03-01

    Fe-Ni metal-schreibersite-troilite intergrowths in Apollo 16 impact melt rocks and new highly siderophile element (HSE) and S abundance data indicate that millimeter-scale closed-system fractional crystallization processes during cooling of impactor-derived metal melt droplets in impact-melts are the main reason for compositional variations and strong differences in abundances and ratios of HSE in multiple aliquots from Apollo 16 impact melt rocks. Element ratios obtained from linear regression of such data are therefore prone to error, but weighted averages take into account full element budgets in the samples and thus represent a more accurate estimate of their impactor contributions. Modeling of solid metal-liquid metal partitioning in the Fe-Ni-S-P system and HSE patterns in impactites from different landing sites suggest that bulk compositions of ancient lunar impactites should be representative of impact melt compositions and that large-scale fractionation of the HSE by in situ segregation of solid metal or sulfide liquid in impact melt sheets most likely did not occur. The compositional record of lunar impactites indicates accretion of variable amounts of chondritic and non-chondritic impactor material and the mixing of these components during remelting of earlier ejecta deposits. The non-chondritic composition appears most prominently in some Apollo 16 impactites and is characterized by suprachondritic HSE/Ir ratios which increase from refractory to moderately volatile HSE and exhibit a characteristic enrichment of Ru relative to Pt. Large-scale fractional crystallization of solid metal from sulfur and phosphorous rich metallic melt with high P/S in planetesimal or embryo cores is currently the most likely process that may have produced these compositions. Similar materials or processes may have contributed to the HSE signature of the bulk silicate Earth (BSE).

  14. A comparative study evaluating the tolerability and efficacy of two topical therapies for the treatment of keloids and hypertrophic scars.

    PubMed

    Perez, Oliver A; Viera, Martha H; Patel, Jitendra K; Konda, Sailesh; Amini, Sadegh; Huo, Ran; Zell, Deborah; Tadicherla, Sujatha; Berman, Brian

    2010-05-01

    Onion extract gel (OE) and 0.5% hydrocortisone, silicone and vitamin E lotion (HSE) are two over-the-counter preparations used to enhance the cosmesis of keloids and hypertrophic scars. To determine the tolerability and efficacy of OE versus HSE versus placebo in subjects with keloids and hypertrophic scars. Thirty subjects (> or =18 years) with keloids or hypertrophic scars were randomly assigned to one of three study preparations for 16 weeks. Scar volume was measured at baseline and weeks 4, 8, 12 and 16. Subjects and blinded investigators assessed scar parameters (induration, erythema, pigmentation alteration, pain, itching, tenderness and cosmetic appearance) and patient satisfaction at each visit using a visual analog scale (VAS). Data analysis included: mean percentage change (MPC) for subjects completing the study (n = 15); the mixed model test to determine differences between the groups over time; and the Kruskal-Wallis test for the analysis of differences in subjects' satisfaction within the three groups over 16 weeks for subjects who completed at least one follow-up visit (n = 21). All three preparations were well tolerated with the exception of a mild acneiform-like eruption in one OE patient. Significant improvements were obtained with OE in volume, length, width and induration and with HSE in volume, length, induration, erythema and pigmentation alteration. There was a trend showing that a higher percentage of subjects were satisfied with OE than with HSE or placebo. The Mix Model Analysis (MMA) showed significant improvements with OE over placebo in investigator cosmetic assessment, lesion induration, pigmentation and tenderness and with HSE over placebo in investigator cosmetic assessment, lesion induration, pigmentation and erythema. Improvements in erythema and pigmentation were significantly greater in HSE than in OE. Both OE and HSE were more effective than placebo in the management of hypertrophic scars and keloids.

  15. Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency

    PubMed Central

    Sancho-Shimizu, Vanessa; Pérez de Diego, Rebeca; Lorenzo, Lazaro; Halwani, Rabih; Alangari, Abdullah; Israelsson, Elisabeth; Fabrega,, Sylvie; Cardon, Annabelle; Maluenda, Jerome; Tatematsu, Megumi; Mahvelati, Farhad; Herman, Melina; Ciancanelli, Michael; Guo, Yiqi; AlSum, Zobaida; Alkhamis, Nouf; Al-Makadma, Abdulkarim S.; Ghadiri, Ata; Boucherit, Soraya; Plancoulaine, Sabine; Picard, Capucine; Rozenberg, Flore; Tardieu, Marc; Lebon, Pierre; Jouanguy, Emmanuelle; Rezaei, Nima; Seya, Tsukasa; Matsumoto, Misako; Chaussabel, Damien; Puel, Anne; Zhang, Shen-Ying; Abel, Laurent; Al-Muhsen, Saleh; Casanova, Jean-Laurent

    2011-01-01

    Herpes simplex encephalitis (HSE) is the most common sporadic viral encephalitis of childhood. Autosomal recessive (AR) UNC-93B and TLR3 deficiencies and autosomal dominant (AD) TLR3 and TRAF3 deficiencies underlie HSE in some children. We report here unrelated HSE children with AR or AD TRIF deficiency. The AR form of the disease was found to be due to a homozygous nonsense mutation that resulted in a complete absence of the TRIF protein. Both the TLR3- and the TRIF-dependent TLR4 signaling pathways were abolished. The AD form of disease was found to be due to a heterozygous missense mutation, resulting in a dysfunctional protein. In this form of the disease, the TLR3 signaling pathway was impaired, whereas the TRIF-dependent TLR4 pathway was unaffected. Both patients, however, showed reduced capacity to respond to stimulation of the DExD/H-box helicases pathway. To date, the TRIF-deficient patients with HSE described herein have suffered from no other infections. Moreover, as observed in patients with other genetic etiologies of HSE, clinical penetrance was found to be incomplete, as some HSV-1–infected TRIF-deficient relatives have not developed HSE. Our results provide what we believe to be the first description of human TRIF deficiency and a new genetic etiology for HSE. They suggest that the TRIF-dependent TLR4 and DExD/H-box helicase pathways are largely redundant in host defense. They further demonstrate the importance of TRIF for the TLR3-dependent production of antiviral IFNs in the CNS during primary infection with HSV-1 in childhood. PMID:22105173

  16. Prevalence of Intrathecal Acyclovir Resistant Virus in Herpes Simplex Encephalitis Patients

    PubMed Central

    Mitterreiter, Johanna G.; Titulaer, Maarten J.; van Nierop, Gijsbert P.; van Kampen, Jeroen J. A.; Aron, Georgina I.; Osterhaus, Albert D. M. E.; Verjans, Georges M. G. M.; Ouwendijk, Werner J. D.

    2016-01-01

    Herpes simplex encephalitis (HSE) is a life-threatening complication of herpes simplex virus (HSV) infection. Acyclovir (ACV) is the antiviral treatment of choice, but may lead to emergence of ACV-resistant (ACVR) HSV due to mutations in the viral UL23 gene encoding for the ACV-targeted thymidine kinase (TK) protein. Here, we determined the prevalence of intrathecal ACVR–associated HSV TK mutations in HSE patients and compared TK genotypes of sequential HSV isolates in paired cerebrospinal fluid (CSF) and blister fluid of mucosal HSV lesions. Clinical samples were obtained from 12 HSE patients, encompassing 4 HSV type 1 (HSV-1) and 8 HSV-2 encephalitis patients. HSV DNA load was determined by real-time PCR and complete HSV TK gene sequences were obtained by nested PCR followed by Sanger sequencing. All HSV-1 HSE patients contained viral TK mutations encompassing 30 unique nucleotide and 13 distinct amino acid mutations. By contrast, a total of 5 unique nucleotide and 4 distinct amino acid changes were detected in 7 of 8 HSV-2 patients. Detected mutations were identified as natural polymorphisms located in non-conserved HSV TK gene regions. ACV therapy did not induce the emergence of ACVR-associated HSV TK mutations in consecutive CSF and mucocutaneous samples of 5 individual patients. Phenotypic susceptibility analysis of these mucocutaneous HSV isolates demonstrated ACV-sensitive virus in 2 HSV-1 HSE patients, whereas in two HSV-2 HSE patients ACVR virus was detected in the absence of known ACVR-associated TK mutations. In conclusion, we did not detect intrathecal ACVR-associated TK mutations in HSV isolates obtained from 12 HSE patients. PMID:27171421

  17. Dissimilatory Reduction of Elemental Selenium to Selenide in Sediments and Anaerobic Cultures of Selenium Respiring Bacteria

    NASA Astrophysics Data System (ADS)

    Herbel, M. J.; Switzer-Blum, J.; Oremland, R. S.

    2001-12-01

    Selenium contaminated environments often contain elemental Se (Se0) in their sediments that originates from dissimilatory reduction of Se oxyanions. The forms of Se in sedimentary rocks similarly contain high proportions of Se0, but much of the Se is also in the form of metal selenides, Se-2. It is not clear if the occurrence of these selenides is due to microbial reduction of Se0, or some other biological or chemical process. In this investigation we examined the possibility that bacterial respiratory reduction of Se0 to Se-2 could explain the presence of the latter species in sedimentary rocks. We conducted incubations of anoxic sediment slurries amended with different forms of Se0. High levels of Se0 (mM) were added to San Francisco Bay sediments in order to enhance the detection of soluble HSe-, which was precipitated with Cu2+ then redissolved and quantified by ICP-MS. Concentrations of HSe- were highest in live samples amended with red amorphous Se0 formed by either microbial reduction of Se+4 ("biogenic Se0") or by chemical oxidation of H2Se(g) ("chem. Se0"); very little HSe- was formed in those amended with black crystalline Se0, indicating the general lack of reactivity of this allotrope. Controls poisoned with 10% formalin did not produce HSe- from additions of chem. Se0. Reduction of both forms of red amorphous Se0 to HSe- occurred vigorously in growing cultures of Bacillus selenitireducens, an anaerobic halophile previously isolated from sediments of Mono Lake, CA. Up to 73% and 68% of red amorphous, biogenic Se0 or chem. Se0, respectively, was reduced to HSe- during growth of B. selenitireducens, (incubation time ~ 200 hrs): oxidation of lactate to acetate as well as cell density increases indicated that a dissimilatory reduction pathway was likely. Reduction was most enhanced when cells were previously grown on elemental sulfur or Se+4. In contrast to the growth experiments, washed cell suspensions of B. selenitireducens exhibited no HSe- production

  18. Asking about Sex in General Health Surveys: Comparing the Methods and Findings of the 2010 Health Survey for England with Those of the Third National Survey of Sexual Attitudes and Lifestyles

    PubMed Central

    Prah, Philip; Johnson, Anne M.; Nardone, Anthony; Clifton, Soazig; Mindell, Jennifer S.; Copas, Andrew J.; Robinson, Chloe; Craig, Rachel; Woodhall, Sarah C.; Macdowall, Wendy; Fuller, Elizabeth; Erens, Bob; Sonnenberg, Pam; Wellings, Kaye; Mercer, Catherine H.

    2015-01-01

    Objectives Including questions about sexual health in the annual Health Survey for England (HSE) provides opportunities for regular measurement of key public health indicators, augmenting Britain's decennial National Survey of Sexual Attitudes and Lifestyles (Natsal). However, contextual and methodological differences may limit comparability of the findings. We examine the extent of these differences between HSE 2010 and Natsal-3 and investigate their impact on parameter estimates. Methods Complex survey analyses of data from men and women in the 2010 HSE (n = 2,782 men and 3,588 women) and Natsal-3 undertaken 2010–2012 (n = 4,882 men and 6,869 women) aged 16-69y and resident in England, both using probability sampling, compared their characteristics, the amount of non-response to, and estimates from, sexual health questions. Both surveys used self-completion for the sexual behaviour questions but this was via computer-assisted self-interview (CASI) in Natsal-3 and a pen-and-paper questionnaire in HSE 2010. Results The surveys achieved similar response rates, both around 60%, and demographic profiles largely consistent with the census, although HSE participants tended to be less educated, and reported worse general health, than Natsal-3 participants. Item non-response to the sexual health questions was typically higher in HSE 2010 (range: 9–18%) relative to Natsal-3 (all <5%). Prevalence estimates for sexual risk behaviours and STI-related indicators were generally slightly lower in HSE 2010 than Natsal-3. Conclusions While a relatively high response to sexual health questions in HSE 2010 demonstrates the feasibility of asking such questions in a general health survey, differences with Natsal-3 do exist. These are likely due to the HSE’s context as a general health survey and methodological limitations such as its current use of pen-and-paper questionnaires. Methodological developments to the HSE should be considered so that its data can be interpreted in

  19. Controls on Highly Siderophile Element Concentrations in Martian Basalt: Sulfide Saturation and Under-Saturation

    NASA Technical Reports Server (NTRS)

    Righter, Kevin

    2009-01-01

    Highly siderophile elements (HSE; Re, Au and the platinum group elements) in shergottites exhibit a wide range from very high, similar to the terrestrial mantle, to very low, similar to sulfide saturated mid ocean ridge basalt (e.g., [1]). This large range has been difficult to explain without good constraints on sulfide saturation or under-saturation [2]. A new model for prediction of sulfide saturation places new constraints on this problem [3]. Shergottite data: For primitive shergottites, pressure and temperature estimates are between 1.2-1.5 GPa, and 1350-1470 C [4]. The range of oxygen fugacities is from FMQ-2 to IW, where the amount of Fe2O3 is low and thus does not have a significant effect on the S saturation values. Finally, the bulk compositions of shergottites have been reported in many recent studies (e.g., [5]). All of this information will be used to test whether shergottites are sulfide saturated [3]. Modeling values and results: The database for HSE partition coefficients has been growing with many new data for silicates and oxides [6-8] to complement a large sulfide database [9- 11]. Combining these data with simple batch melting models allows HSE contents of mantle melts to be estimated for sulfide-bearing vs. sulfide-free mantle. Combining such models with fractional crystallization modeling (e.g., [12]) allows HSE contents of more evolved liquids to be modeled. Most primitive shergottites have high HSE contents (and low S contents) that can be explained by sulfide under-saturated melting of the mantle. An exception is Dhofar 019 which has high S contents and very low HSE contents suggesting sulfide saturation. Most evolved basaltic shergottites have lower S contents than saturation, and intermediate HSE contents that can be explained by olivine, pyroxene, and chromite fractionation. An exception is EET A79001 lithology B, which has very low HSE contents and S contents higher than sulfide saturation values . evidence for sulfide saturation

  20. Pt, Au, Pd and Ru Partitioning Between Mineral and Silicate Melts: The Role of Metal Nanonuggets

    NASA Technical Reports Server (NTRS)

    Malavergne, V.; Charon, E.; Jones, J.; Agranier, A.; Campbell, A.

    2012-01-01

    The partition coefficients of Pt and other Pt Group Elements (PGE) between metal and silicate D(sub Metal-Silicate) and also between silicate minerals and silicate melts D(sub Metal-Silicate) are among the most challenging coefficients to obtain precisely. The PGE are highly siderophile elements (HSE) with D(sub Metal-Silicate) >10(exp 3) due to the fact that their concentrations in silicates are very low (ppb to ppt range). Therefore, the analytical difficulty is increased by the possible presence of HSE-rich-nuggets in reduced silicate melts during experiments). These tiny HSE nuggets complicate the interpretation of measured HSE concentrations. If the HSE micro-nuggets are just sample artifacts, then their contributions should be removed before calculations of the final concentration. On the other hand, if they are produced during the quench, then they should be included in the analysis. We still don't understand the mechanism of nugget formation well. Are they formed during the quench by precipitation from precursor species dissolved homogeneously in the melts, or are they precipitated in situ at high temperature due to oversaturation? As these elements are important tracers of early planetary processes such as core formation, it is important to take up this analytical and experimental challenge. In the case of the Earth for example, chondritic relative abundances of the HSE in some mantle xenoliths have led to the concept of the "late veneer" as a source of volatiles (such as water) and siderophiles in the silicate Earth. Silicate crystal/liquid fractionation is responsible for most, if not all, the HSE variation in the martian meteorite suites (SNC) and Pt is the element least affected by these fractionations. Therefore, in terms of reconstructing mantle HSE abundances for Mars, Pt becomes a very important player. In the present study, we have performed high temperature experiments under various redox conditions in order to determine the abundances of Pt, Au

  1. Osmium isotopes and highly siderophile elements in lunar glasses

    NASA Astrophysics Data System (ADS)

    Horan, M.; Walker, R.; Shearer, C.; Papike, J.

    2003-04-01

    The absolute and relative abundances of the highly siderophile elements (HSE) present in planetary mantles are primarily controlled by silicate-metal partitioning during core-mantle differentiation and by later planetary accretion. Constraints on HSE distributions in the lunar mantle will provide insights to the formation and late accretionary history of not only the Moon, but also Earth. Because no samples of the lunar mantle have been collected, the only materials presently available for constraining mantle abundances are lunar volcanic rocks. The Apollo 15 green and Apollo 17 orange glasses are spherules derived from fire-fountain eruptions of mare basalts. These glasses are more primitive than the mare basalts, and probably were derived by the melting of cumulate assemblages from the lunar magma ocean in the deep interior (> 400 km). Despite our limited understanding of mantle-melt partitioning of the HSE, even for terrestrial systems, these glasses provide the best hope for constraining the HSE composition of the lunar interior. We report Os isotopic composition data and Re, Os, Ir, Ru, Pt and Pd isotope dilution concentration data for green glass (15426,164) and orange glass (74001,1217). Absolute and relative abundances of HSE are variable. The green glass has elemental ratios of the HSE and an Os isotopic composition within the range defined by chondritic meteorites, suggesting that the HSE were dominated by a meteoritic contaminant. This sample probably provides little information about the lunar interior, but may help constrain the types of meteorites impacting the lunar surface. Two size fractions (180-325 mesh and 75-180 mesh) of the orange glass were analyzed. HSE patterns for both size fractions are fractionated, having higher chondrite-normalized abundances of Pt and Pd, compared with Os and Ir. The supra-chondritic 187Os/188Os ratio (0.1339) of the finer fraction indicates modestly fractionated Re/Os relative to chondritic. The coarser size fraction

  2. Osmium isotope and highly siderophile element systematics of lunar impact melt breccias: Implications for the late accretion history of the Moon and Earth

    NASA Astrophysics Data System (ADS)

    Puchtel, Igor S.; Walker, Richard J.; James, Odette B.; Kring, David A.

    2008-06-01

    To characterize the compositions of materials accreted to the Earth-Moon system between about 4.5 and 3.8 Ga, we have determined Os isotopic compositions and some highly siderophile element (HSE: Re, Os, Ir, Ru, Pt, and Pd) abundances in 48 subsamples of six lunar breccias. These are: Apollo 17 poikilitic melt breccias 72395 and 76215; Apollo 17 aphanitic melt breccias 73215 and 73255; Apollo 14 polymict breccia 14321; and lunar meteorite NWA482, a crystallized impact melt. Plots of Ir versus other HSE define excellent linear correlations, indicating that all data sets likely represent dominantly two-component mixtures of a low-HSE target, presumably endogenous component, and a high-HSE, presumably exogenous component. Linear regressions of these trends yield intercepts that are statistically indistinguishable from zero for all HSE, except for Ru and Pd in two samples. The slopes of the linear regressions are insensitive to target rock contributions of Ru and Pd of the magnitude observed; thus, the trendline slopes approximate the elemental ratios present in the impactor components contributed to these rocks. The 187Os/188Os and regression-derived elemental ratios for the Apollo 17 aphanitic melt breccias and the lunar meteorite indicate that the impactor components in these samples have close affinities to chondritic meteorites. The HSE in the Apollo 17 aphanitic melt breccias, however, might partially or entirely reflect the HSE characteristics of HSE-rich granulitic breccia clasts that were incorporated in the impact melt at the time of its creation. In this case, the HSE characteristics of these rocks may reflect those of an impactor that predated the impact event that led to the creation of the melt breccias. The impactor components in the Apollo 17 poikilitic melt breccias and in the Apollo 14 breccia have higher 187Os/188Os, Pt/Ir, and Ru/Ir and lower Os/Ir than most chondrites. These compositions suggest that the impactors they represent were chemically

  3. Osmium isotope and highly siderophile element systematics of lunar impact melt breccias: Implications for the late accretion history of the Moon and Earth

    USGS Publications Warehouse

    Puchtel, I.S.; Walker, R.J.; James, O.B.; Kring, D.A.

    2008-01-01

    To characterize the compositions of materials accreted to the Earth-Moon system between about 4.5 and 3.8 Ga, we have determined Os isotopic compositions and some highly siderophile element (HSE: Re, Os, Ir, Ru, Pt, and Pd) abundances in 48 subsamples of six lunar breccias. These are: Apollo 17 poikilitic melt breccias 72395 and 76215; Apollo 17 aphanitic melt breccias 73215 and 73255; Apollo 14 polymict breccia 14321; and lunar meteorite NWA482, a crystallized impact melt. Plots of Ir versus other HSE define excellent linear correlations, indicating that all data sets likely represent dominantly two-component mixtures of a low-HSE target, presumably endogenous component, and a high-HSE, presumably exogenous component. Linear regressions of these trends yield intercepts that are statistically indistinguishable from zero for all HSE, except for Ru and Pd in two samples. The slopes of the linear regressions are insensitive to target rock contributions of Ru and Pd of the magnitude observed; thus, the trendline slopes approximate the elemental ratios present in the impactor components contributed to these rocks. The 187Os/188Os and regression-derived elemental ratios for the Apollo 17 aphanitic melt breccias and the lunar meteorite indicate that the impactor components in these samples have close affinities to chondritic meteorites. The HSE in the Apollo 17 aphanitic melt breccias, however, might partially or entirely reflect the HSE characteristics of HSE-rich granulitic breccia clasts that were incorporated in the impact melt at the time of its creation. In this case, the HSE characteristics of these rocks may reflect those of an impactor that predated the impact event that led to the creation of the melt breccias. The impactor components in the Apollo 17 poikilitic melt breccias and in the Apollo 14 breccia have higher 187Os/188Os, Pt/Ir, and Ru/Ir and lower Os/Ir than most chondrites. These compositions suggest that the impactors they represent were chemically

  4. Rhodium, gold and other highly siderophile element abundances in chondritic meteorites

    NASA Astrophysics Data System (ADS)

    Fischer-Gödde, M.; Becker, H.; Wombacher, F.

    2010-01-01

    The abundances of the highly siderophile elements (HSE) Re, Os, Ir, Ru, Pt, Rh, Pd and Au, and 187Os/ 188Os isotope ratios have been determined for a set of carbonaceous, ordinary, enstatite and Rumuruti chondrites, using an analytical technique that permits the precise and accurate measurement of all HSE from the same digestion aliquot. Concentrations of Re, Os, Ir, Ru, Pt and Pd were determined by isotope dilution ICP-MS and N-TIMS analysis. The monoisotopic elements Rh and Au were quantified relative to the abundance of Ir. Differences in HSE abundances and ratios such as Re/Os, 187Os/ 188Os, Pd/Ir and Au/Ir between different chondrite classes are further substantiated with new data, and additional Rh and Au data, including new data for CI chondrites. Systematically different relative abundances of Rh between different chondrite classes are reminiscent of the behaviour of Re. Carbonaceous chondrites are characterized by low average Rh/Ir of 0.27 ± 0.03 (1s) which is about 20% lower than the ratio for ordinary (0.34 ± 0.02) and enstatite chondrites (EH: 0.33 ± 0.01; EL: 0.32 ± 0.01). R chondrites show higher and somewhat variable Rh/Ir of 0.37 ± 0.07. Well-defined linear correlations of HSE, in particular for bulk samples of ordinary and EL chondrites, are explained by binary mixing and/or dilution by silicates. The HSE carriers responsible for these correlations have a uniform chemical composition, indicating efficient homogenization of local nebular heterogeneities during or prior to the formation of the host minerals in chondrite components. Excepting Rumuruti chondrites and Au in carbonaceous chondrites, these correlations also suggest that metamorphism, alteration and igneous processes had negligible influence on the HSE distribution on the bulk sample scale. Depletion patterns for Rh, Pd and Au in carbonaceous chondrites other than CI are smoothly related to condensation temperatures and therefore consistent with the general depletion of moderately

  5. Development of a Full-Thickness Human Skin Equivalent In Vitro Model Derived from TERT-Immortalized Keratinocytes and Fibroblasts.

    PubMed

    Reijnders, Christianne M A; van Lier, Amanda; Roffel, Sanne; Kramer, Duco; Scheper, Rik J; Gibbs, Susan

    2015-09-01

    Currently, human skin equivalents (HSEs) used for in vitro assays (e.g., for wound healing) make use of primary human skin cells. Limitations of primary keratinocytes and fibroblasts include availability of donor skin and donor variation. The use of physiologically relevant cell lines could solve these limitations. The aim was to develop a fully differentiated HSE constructed entirely from human skin cell lines, which could be applied for in vitro wound-healing assays. Skin equivalents were constructed from human TERT-immortalized keratinocytes and fibroblasts (TERT-HSE) and compared with native skin and primary HSEs. HSEs were characterized by hematoxylin-eosin and immunohistochemical stainings with markers for epidermal proliferation and differentiation, basement membrane (BM), fibroblasts, and the extracellular matrix (ECM). Ultrastructure was determined with electron microscopy. To test the functionality of the TERT-HSE, burn and cold injuries were applied, followed by immunohistochemical stainings, measurement of reepithelialization, and determination of secreted wound-healing mediators. The TERT-HSE was composed of a fully differentiated epidermis and a fibroblast-populated dermis comparable to native skin and primary HSE. The epidermis consisted of proliferating keratinocytes within the basal layer, followed by multiple spinous layers, a granular layer, and cornified layers. Within the TERT-HSE, the membrane junctions such as corneosomes, desmosomes, and hemidesmosomes were well developed as shown by ultrastructure pictures. Furthermore, the BM consisted of a lamina lucida and lamina densa comparable to native skin. The dermal matrix of the TERT-HSE was more similar to native skin than the primary construct, since collagen III, an ECM marker, was present in TERT-HSEs and absent in primary HSEs. After wounding, the TERT-HSE was able to reepithelialize and secrete inflammatory wound-healing mediators. In conclusion, the novel TERT-HSE, constructed entirely

  6. Development of a Full-Thickness Human Skin Equivalent In Vitro Model Derived from TERT-Immortalized Keratinocytes and Fibroblasts

    PubMed Central

    Reijnders, Christianne M.A.; van Lier, Amanda; Roffel, Sanne; Kramer, Duco; Scheper, Rik J.

    2015-01-01

    Currently, human skin equivalents (HSEs) used for in vitro assays (e.g., for wound healing) make use of primary human skin cells. Limitations of primary keratinocytes and fibroblasts include availability of donor skin and donor variation. The use of physiologically relevant cell lines could solve these limitations. The aim was to develop a fully differentiated HSE constructed entirely from human skin cell lines, which could be applied for in vitro wound-healing assays. Skin equivalents were constructed from human TERT-immortalized keratinocytes and fibroblasts (TERT-HSE) and compared with native skin and primary HSEs. HSEs were characterized by hematoxylin–eosin and immunohistochemical stainings with markers for epidermal proliferation and differentiation, basement membrane (BM), fibroblasts, and the extracellular matrix (ECM). Ultrastructure was determined with electron microscopy. To test the functionality of the TERT-HSE, burn and cold injuries were applied, followed by immunohistochemical stainings, measurement of reepithelialization, and determination of secreted wound-healing mediators. The TERT-HSE was composed of a fully differentiated epidermis and a fibroblast-populated dermis comparable to native skin and primary HSE. The epidermis consisted of proliferating keratinocytes within the basal layer, followed by multiple spinous layers, a granular layer, and cornified layers. Within the TERT-HSE, the membrane junctions such as corneosomes, desmosomes, and hemidesmosomes were well developed as shown by ultrastructure pictures. Furthermore, the BM consisted of a lamina lucida and lamina densa comparable to native skin. The dermal matrix of the TERT-HSE was more similar to native skin than the primary construct, since collagen III, an ECM marker, was present in TERT-HSEs and absent in primary HSEs. After wounding, the TERT-HSE was able to reepithelialize and secrete inflammatory wound-healing mediators. In conclusion, the novel TERT-HSE, constructed entirely

  7. Mantle-crust interactions in a paleosubduction zone: Evidence from highly siderophile element systematics of eclogite and related rocks

    NASA Astrophysics Data System (ADS)

    Penniston-Dorland, Sarah C.; Walker, Richard J.; Pitcher, Lynnette; Sorensen, Sorena S.

    2012-02-01

    Substantial differences in 187Os/188Os and absolute and relative abundances of highly siderophile elements (HSE: Os, Ir, Ru, Pt, Pd, Re) in mantle peridotites compared to oceanic crust indicate that this suite of elements may prove useful in assessing mechanisms and pathways of mantle and slab mass transfer within the subduction channel. Currently, however, information regarding the mobility of the HSE in subduction zone environments is limited. To better understand the systematics of highly siderophile elements in subduction settings, we measured Os isotopic compositions and HSE abundances of cores and rinds of meter-scale blocks of eclogite, blueschist and garnet amphibolite from subduction-related mélanges within 1) the Franciscan Complex, CA, and a related terrane in Oregon; 2) the Catalina Schist, CA; and 3) the Samana Metamorphic Complex, Samana Peninsula, Dominican Republic. Rinds composed of amphibole, chlorite, ± phengite, talc, titanite and rutile partly enclose blocks at each location. Mineralogic, petrologic and geochemical data suggest that these rinds are metasomatic features that formed by fluid-mediated interaction between mafic blocks and an ultramafic matrix. The cores of high-grade blocks are characterized by high (Pt + Pd)/(Os + Ir + Ru), and variably radiogenic Os; initial 187Os/188Os ranges from 0.197 to 4.30. These characteristics are consistent with the HSE compositions of subducted basalts. In contrast, (Pt + Pd)/(Os + Ir + Ru) of rinds are generally much lower than cores, approaching values typical of mantle peridotites. The initial 187Os/188Os of most rinds are also typical of upper mantle peridotites; values for most rinds fall between 0.125 and 0.14. The similarities of the 187Os/188Os and HSE abundances between rinds and mantle peridotites indicate that the HSE contained within rinds reflect a contribution by mantle peridotite, whether by fluid-mediated transfer or through mechanical processes. If the HSE signatures of the rinds were

  8. Hybridization leads to sensory repertoire expansion in a gynogenetic fish, the Amazon molly (poecilia formosa): a test of the hybrid-sensory expansion hypothesis.

    PubMed

    Sandkam, Benjamin A; Joy, Jeffrey B; Watson, Corey T; Gonzalez-Bendiksen, Pablo; Gabor, Caitlin R; Breden, Felix

    2013-01-01

    Expansions in sensory systems usually require processes such as gene duplication and divergence, and thus evolve slowly. We evaluate a novel mechanism leading to rapid sensory repertoire expansion: hybrid-sensory expansion (HSE). HSE occurs when two species with differently tuned sensory systems form a hybrid, bringing together alleles from each of the parental species. In one generation, a sensory repertoire is created that is the sum of the variance between parental species. The Amazon molly presents a unique opportunity to test the HSE hypothesis in a "frozen" hybrid. We compared opsin sequences of the Amazon molly, Poecilia formosa, to those of the parental species. Both parental species are homozygous at the RH2-1 locus and each of the four long wavelength sensitive loci, while P. formosa possess two different alleles at these loci; one matching each parental allele. Gene expression analysis showed P. formosa use the expanded opsin repertoire that was the result of HSE. Additionally, behavioral tests revealed P. formosa respond to colored stimuli in a manner similar or intermediate to the parental species P. mexicana and P. latipinna. Together these results strongly support the HSE hypothesis. Hybrid-sensory repertoire expansion is likely important in other hybrid species and in other sensory systems.

  9. Health, safety and environmental unit performance assessment model under uncertainty (case study: steel industry).

    PubMed

    Shamaii, Azin; Omidvari, Manouchehr; Lotfi, Farhad Hosseinzadeh

    2017-01-01

    Performance assessment is a critical objective of management systems. As a result of the non-deterministic and qualitative nature of performance indicators, assessments are likely to be influenced by evaluators' personal judgments. Furthermore, in developing countries, performance assessments by the Health, Safety and Environment (HSE) department are based solely on the number of accidents. A questionnaire is used to conduct the study in one of the largest steel production companies in Iran. With respect to health, safety, and environment, the results revealed that control of disease, fire hazards, and air pollution are of paramount importance, with coefficients of 0.057, 0.062, and 0.054, respectively. Furthermore, health and environment indicators were found to be the most common causes of poor performance. Finally, it was shown that HSE management systems can affect the majority of performance safety indicators in the short run, whereas health and environment indicators require longer periods of time. The objective of this study is to present an HSE-MS unit performance assessment model in steel industries. Moreover, we seek to answer the following question: what are the factors that affect HSE unit system in the steel industry? Also, for each factor, the extent of impact on the performance of the HSE management system in the organization is determined.

  10. Combined hybrid functional and DFT+U calculations for metal chalcogenides

    SciTech Connect

    Aras, Mehmet; Kılıç, Çetin

    2014-07-28

    In the density-functional studies of materials with localized electronic states, the local/semilocal exchange-correlation functionals are often either combined with a Hubbard parameter U as in the LDA+U method or mixed with a fraction of exactly computed (Fock) exchange energy yielding a hybrid functional. Although some inaccuracies of the semilocal density approximations are thus fixed to a certain extent, the improvements are not sufficient to make the predictions agree with the experimental data. Here, we put forward the perspective that the hybrid functional scheme and the LDA+U method should be treated as complementary, and propose to combine the range-separated Heyd-Scuseria-Ernzerhof (HSE) hybrid functional with the Hubbard U. We thus present a variety of HSE+U calculations for a set of II-VI semiconductors, consisting of zinc and cadmium monochalcogenides, along with comparison to the experimental data. Our findings imply that an optimal value U{sup *} of the Hubbard parameter could be determined, which ensures that the HSE+U{sup *} calculation reproduces the experimental band gap. It is shown that an improved description not only of the electronic structure but also of the crystal structure and energetics is obtained by adding the U{sup *} term to the HSE functional, proving the utility of HSE+U{sup *} approach in modeling semiconductors with localized electronic states.

  11. Soret separation of highly siderophile elements in Fe-Ni-S melts: Implications for solid metal-liquid metal partitioning

    NASA Astrophysics Data System (ADS)

    Brenan, James M.; Bennett, Neil

    2010-10-01

    Soret separation of melts consisting of Fe (+ 1-10 wt.% Ni) with added C, Si or S and trace highly siderophile elements (HSE; Ru, Rh, Pd, Re, Os, Ir, Pt and Au) was investigated in experiments done at 2 GPa, T hot ~ 2000 °C and T hot-T cold ~ 250 °C. Experiments with added C and Si produced homogeneous samples, whereas those with S resulted in significant compositional gradients, with S enriched at the hot end of the sample, and Fe and HSE enriched at the cold end. The magnitude of the separation of the HSE is not the same for each, but varies in the order (smallest to largest) Pd~AuHSE within experiments is consistent with the variation in activity coefficients for these elements as predicted by the non-metal avoidance model of Jones and Malvin (1990). Thus, our results indicate that the melt composition effect on solid metal-liquid metal partitioning can be captured in a single thermal diffusion experiment. The magnitude of the melt composition effect, as judged by the Jones-Malvin interaction parameter, β, varies with metal size in a manner similar to solid metal-liquid metal partition coefficients, suggesting like origins of the HSE "selectivity" for Fe-rich solid or liquid structures.

  12. Os-187/Os-188 and Highly Siderophile Element Systematics of Apollo 17 Aphanitic Melt Rocks

    NASA Technical Reports Server (NTRS)

    Puchtel, I. S.; Walker, R. J.; James, O. B.

    2005-01-01

    Introduction: Generally chondritic relative abundances and high absolute abundances of the highly siderophile elements (HSE: Ru, Rh, Pd, Re, Os, Ir, Pt, Au) in Earth s upper mantle provide strong evidence that these elements were added to the Earth following the last major interaction between its metallic core and silicate fraction. So called "late accretion" may have added materials comprising as much as 0.8% of the total mass of the Earth and possibly a similar proportion of mass to the Moon. We have begun to study the chemical nature of late accreted materials to the Earth - Moon system by examining the HSE contained in lunar impact-melt rocks. The HSE contained in melt rocks were largely added to the Moon during the period of time from the origin of the lunar highlands crust (4.4- 4.5 Ga) to the end of the late bombardment period (ca. 3.9 Ga). These materials provide the only direct chemical link to the late accretionary period. The chemical fingerprints of the HSE in late accreted materials may enable us to ascertain under what conditions and where in the solar system the late accreted materials formed. The Os-187/Os-188 ratios (reflecting long-term Re/Os), coupled with ratios of other HSE, can be diagnostic for identifying the nature of the impactor. A critical issue, however, will be deconvolving the exogenous from indigenous components.

  13. The role of laboratory investigation in the diagnosis and management of patients with suspected herpes simplex encephalitis: a consensus report. The EU Concerted Action on Virus Meningitis and Encephalitis.

    PubMed Central

    Cinque, P; Cleator, G M; Weber, T; Monteyne, P; Sindic, C J; van Loon, A M

    1996-01-01

    As effective therapies for the treatment of herpes simplex encephalitis (HSE) have become available, the virology laboratory has acquired a role of primary importance in the early diagnosis and clinical management of this condition. Several studies have shown that the polymerase chain reaction (PCR) of CSF for the detection of herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2) DNA provides a reliable method for determining an aetiological diagnosis of HSE. The use of PCR in combination with the detection of a specific intrathecal antibody response to HSV currently represents the most reliable strategy for the diagnosis and monitoring of the treatment of adult patients with HSE. The use of these techniques has also led to the identification of atypical presentations of HSV infections of the nervous system and permits the investigation of patients who develop a relapse of encephalitic illness after an initial episode of HSE. A strategy for the optimal use of the investigative laboratory in the diagnosis of HSE and subsequent management decisions is described. Images PMID:8890768

  14. Induction of the DNA-binding and transcriptional activities of heat shock factor 1 is uncoupled in Xenopus oocytes.

    PubMed

    Bharadwaj, S; Hnatov, A; Ali, A; Ovsenek, N

    1998-03-12

    The DNA-binding and transcriptional activities of the heat shock transcription factor 1 (HSF1) are repressed under normal conditions and rapidly upregulated by heat stress. Here, we tested for the ability of various stress agents to activate HSF1 in the Xenopus oocyte model system. The HSE-binding activity of HSF1 was induced by a number of chemical stresses including cadmium, aluminum, iron, mercury, arsenite, ethanol, methanol, and salicylate. HSE-binding was not induced by several stresses known to induce the synthesis of hsps in other cell types in different organisms including zinc, copper, cobalt, manganese, recovery from anoxia, UV-irradiation, and increased pH. The inability of several known inducers of the stress response to activate the HSE-binding ability of HSF1 suggests that certain stress activation pathways may be absent or inactive in oocytes. The transcriptional activity of oocyte HSF1 was induced by heat, cadmium, and arsenite, but many of the agents that induced HSE-binding failed to stimulate HSF1-mediated transcription. The apparent uncoupling of inducible HSE-binding and transcriptional activities of HSF1 under a variety of stress regimes indicates that these events are regulated by independent mechanisms in the oocyte.

  15. Semantic Development in Spanish-English Bilingual Children: Effects of Age and Language Experience

    PubMed Central

    Sheng, Li; Bedore, Lisa M.; Peña, Elizabeth D.; Fiestas, Christine

    2012-01-01

    This study examines semantic development in 60 Spanish-English bilingual children, ages 7 years 3 months to 9 years 11 months, who differed orthogonally in age (younger, older) and language experience (HEE: higher English experience, HSE: higher Spanish experience). Children produced three associations to 12 pairs of translation equivalents. Older children produced more semantic responses and code-switched more often from Spanish to English than younger children. Within each group, children demonstrated better performance in the more frequently used than the less used language. The HEE children outperformed the HSE children in English and the HSE children outperformed the HEE children in Spanish. These effects of age and language experience are consistent with predictions of the Revised Hierarchical Model of bilingual lexical organization. PMID:23163772

  16. Diverse impactors in Apollo 15 and 16 impact melt rocks: Evidence from osmium isotopes and highly siderophile elements

    NASA Astrophysics Data System (ADS)

    Liu, Jingao; Sharp, Miriam; Ash, Richard D.; Kring, David A.; Walker, Richard J.

    2015-04-01

    Concentrations of highly siderophile elements (HSE) and 187Os/188Os isotopic compositions for eleven impact related rocks from the Apollo 15 and 16 landing sites are reported and combined with existing geochronological data to investigate the chemical nature and temporal changes in the large impactors implicated in the formation of the lunar basins. Data for the samples all define linear trends on plots of HSE versus Ir concentrations, whose slopes likely reflect the relative HSE compositions of the dominant impactors that formed the rocks. The inferred Imbrium basin impactor that generated Apollo 15 impact melt rocks 15445 and 15455 was characterized by modestly suprachondritic 187Os/188Os, Ru/Ir, Pt/Ir and Pd/Ir ratios. Diverse impactor components are revealed in the Apollo 16 impact melt rocks. The 187Os/188Os and HSE/Ir ratios of the impactor components in melt rocks 60635, 63595 and 68416, with reported ages <3.84 Ga, are within the range of chondritic meteorites, but slightly higher than ratios characterizing previously studied granulitic impactites with reported ages >4.0 Ga. By contrast, the impactor components in melt rocks 60235, 62295 and 67095, with reported ages of ∼3.9 Ga, are characterized by suprachondritic 187Os/188Os and HSE/Ir ratios similar to the Apollo 15 impact melt rocks, and may also sample the Imbrium impactor. Three lithic clasts from regolith breccias 60016 and 65095, also with ∼3.9 Ga ages, contain multiple impactor components, of which the dominant composition is considerably more suprachondritic than those implicated for Imbrium and Serenitatis (Apollo 17) impactors. The dominant composition recorded in these rocks was most likely inherited from a pre-Imbrium impactor. Consideration of composition versus age relations among lunar impact melt rocks reveals no discernable trend. Virtually all lunar impact melt rocks sampled by the Apollo missions, as well as meteorites, are characterized by 187Os/188Os and HSE/Ir ratios that, when

  17. Majorite-Garnet Partitioning of the Highly Siderophile Elements: New Results and Application to Mars

    NASA Technical Reports Server (NTRS)

    Danielson, L. R.; Righter, K.; Waeselmann, N.; Humayun, M.

    2015-01-01

    HSE and Os isotopes are used to constrain processes such as accretion, mantle evolution, crustal recycling, and core-mantle mixing, and to constrain the timing and depth of differentiation of Mars. Although showed that the HSE contents of the martian mantle could have been established by metal-silicate equilibrium in early Mars, the role of a cooling magma ocean and associated crystallization in further fractionating the HSEs is unclear. Garnet is thought to have played an important role in controlling trace element concentrations in the martian mantle reservoirs. However, testing these models, including Os isotopes, has been hindered by a dearth of partitioning data for the HSE in deep mantle phases - majorite, wadsleyite, ringwoodite, akimotoite - that may be present in the martian mantle. We examine the partitioning behavior of HSEs between majorite garnet (gt), olivine (oliv), and silicate liquid (melt).

  18. Applications of Screened Hybrid Density Functionals with Empirical Dispersion Corrections to Rare Gas Dimers and Solids.

    PubMed

    Yousaf, Kazim E; Brothers, Edward N

    2010-03-09

    An empirical dispersion correction is added to the range-separated hybrid density functionals HSE and HISS via parametrization versus a standard test bed of weakly bound complexes. The performance of the resulting HSE-D and HISS-D functionals is evaluated by calculating the equilibrium bond length, harmonic frequency, and dissociation energy for a number of rare gas dimers, and the lattice constants, band gaps, and sublimation energies of the rare gas solids. Both HSE-D and HISS-D are shown to provide accurate results for both molecules and extended systems, suggesting that the combination of a screened hybrid functional with an empirical dispersion correction provides an accurate, widely applicable method for use in solid-state and gas-phase electronic structure theory.

  19. [Work-related stress and psychological distress assessment in urban and suburban public transportation companies].

    PubMed

    Romeo, L; Lazzarini, G; Farisè, E; Quintarelli, E; Riolfi, A; Perbellini, L

    2012-01-01

    The risk of work-related stress has been determined in bus drivers and workers employed in the service department of two urban and suburban public transportation companies. The INAIL evaluation method (Check list and HSE indicator tool) was used. The GHQ-12 questionnaire, which is widely used to assess the level of psychological distress, was also employed. 81.9% of workers involved in the survey answered both the HSE indicator tool and the GHQ-12 questionnaire. The Check list evaluation showed an increase in quantifiable company stress indicators while close examination using the HSE indicator tool demonstrated critical situations for all the subscales, with the control subscales more problematic in bus drivers. The demand, manager's support, relationships and change subscales were most associated with psychological distress in bus drivers, while relationships, role, change and demand subscales were negatively related in workers of the service department.

  20. Chronic herpes simplex type-1 encephalitis with intractable epilepsy in an immunosuppressed patient.

    PubMed

    Laohathai, Christopher; Weber, Daniel J; Hayat, Ghazala; Thomas, Florian P

    2016-02-01

    Chronic herpes simplex virus type-1 encephalitis (HSE-1) is uncommon. Past reports focused on its association with prior documented acute infection. Here, we describe a patient with increasingly intractable epilepsy from chronic HSE-1 reactivation without history of acute central nervous system infection. A 49-year-old liver transplant patient with 4-year history of epilepsy after initiation of cyclosporine developed increasingly frequent seizures over 3 months. Serial brain magnetic resonance imaging showed left temporoparietal cortical edema that gradually improved despite clinical decline. Herpes simplex virus type-1 (HSV-1) DNA was detected in cerebrospinal fluid by polymerase chain reaction. Cerebrospinal fluid HSV-1&2 IgM was negative. Seizures were controlled after acyclovir treatment, and the patient remained seizure free at 1-year follow-up. Chronic HSE is a cause of intractable epilepsy, can occur without a recognized preceding acute phase, and the clinical course of infection may not directly correlate with neuroimaging changes.

  1. Naming deficit in herpes simplex encephalitis.

    PubMed

    Barbarotto, R; Capitani, E; Laiacona, M

    1996-04-01

    The preferential involvement of living categories in naming impairment is well recognised in Herpes Simplex Encephalitis (HSE). In this paper we describe naming, neuropsychological and neuroradiological findings with seven fresh HSE cases. Patients were given a picture naming task that included 60 items belonging to 6 different categories (three living, i.e. fruits, vegetables and animals and three non-living, i.e. furniture, vehicles and tools). In the statistical analysis several possible sources of bias as the frequency of the target word, the familiarity with the objects to name, the image complexity and other parameters were taken into account. Four out of seven patients were significantly more impaired with living things. We describe their general cognitive profile and discuss the anatomo-functional aspects of category dissociation. Language impairment, disproportionately severe for the naming of living exemplars, is frequently observed in HSE, is clinically relevant and should be specifically investigated.

  2. The impact of perceived self-efficacy on memory for aversive experiences.

    PubMed

    Brown, Adam D; Joscelyne, Amy; Dorfman, Michelle L; Marmar, Charles R; Bryant, Richard A

    2012-01-01

    Self-efficacy is a key construct underlying healthy functioning and emotional well-being. Perceptions of uncontrollability, unpredictability, and low self-efficacy are consistently associated with negative mental health outcomes, such as post-traumatic stress disorder (PTSD). To test the causal relation between perceived coping self-efficacy and stress responses we employed a trauma film paradigm in which college students (N=33) viewed a graphic film of the aftermath of a motor vehicle accident following a high (HSE) or low self-efficacy (LSE) induction. Participants were tested for intrusions, distress, and memory recall for the film over the following 24 hours. LSE participants recalled more central details than HSE participants. Further, HSE participants reported fewer negative intrusions immediately following the film and at 24 hours. These findings suggest that strategies that increase perceived coping self-efficacy may reduce intrusive recollections of an aversive event, and also reduce the attentional bias associated with remembering aversive stimuli.

  3. Self-consistent GW calculation of the electronic structure of co-doped ZnO

    NASA Astrophysics Data System (ADS)

    Kim, Maengsuk; Park, Chul Hong

    2012-01-01

    The electronic structure of Co-doped ZnO is presented using a first-principles self-consistent GW calculation based on the screened hybrid HSE06 functional and is compared to the structure calculated using the generalized gradient density approximation plus U (GGA+U) method. The obtained energy splittings between unoccupied Co t 2 and the occupied Co e states are about 3.0 eV and 5.1 eV for the GGA+U and the HSE06 calculations, respectively. Through a correction of the self-consistent GW calculations on the top of HSE06, the electronic energy levels of the occupied Co e band states are moved downward slightly while those at the unoccupied Co t 2 bands are shifted upward, and the occupied Co e and the empty Co t 2 levels of the minority spin are located, respectively, far below and far above the conduction band minimum.

  4. Binaural squelch and head shadow effects in children with unilateral cochlear implants and contralateral hearing aids.

    PubMed

    Dincer D'Alessandro, H; Sennaroğlu, G; Yücel, E; Belgin, E; Mancini, P

    2015-10-01

    The aim of this study was to investigate the amount of binaural squelch effect (BSE) and head shadow effect (HSE) in children who use unilateral cochlear implants (CI) and contralateral hearing aids (HA). The study group consisted of 19 CI recipient children who consistently wore a contralateral HA. Speech sounds were used to evaluate speech perception performance in noise. Testing was performed in three listening conditions: (1) bimodal listening with noise source on HA side; (2) CI only with noise source contralaterally (HA off); (3) CI only with noise source on the CI side. Statistical analysis revealed a significant difference between the three listening conditions and post hoc tests indicated significant differences for all pairwise comparisons (p < 0.001). The average BSE and HSE were 11.8% and 17.1% respectively. The majority of bimodal CI users showed BSE and HSE with significant speech perception improvement in the presence of noise.

  5. Semantic development in Spanish-English bilingual children: effects of age and language experience.

    PubMed

    Sheng, Li; Bedore, Lisa M; Peña, Elizabeth D; Fiestas, Christine

    2013-01-01

    This study examines semantic development in 60 Spanish-English bilingual children, ages 7 years 3 months to 9 years 11 months, who differed orthogonally in age (younger, older) and language experience (higher English experience [HEE], higher Spanish experience [HSE]). Children produced 3 associations to 12 pairs of translation equivalents. Older children produced more semantic responses and code switched more often from Spanish to English than younger children. Within each group, children demonstrated better performance in the more frequently used than the less used language. The HEE children outperformed the HSE children in English and the HSE children outperformed the HEE children in Spanish. These effects of age and language experience are consistent with predictions of the revised hierarchical model of bilingual lexical organization.

  6. Akathisia in association with herpes simplex encephalitis relapse and opercular syndrome in children.

    PubMed

    Kocak, Ozan; Yarar, Coskun; Yakut, Ayten; Ekici, Arzu; Yimenicioglu, Sevgi; Saylisoy, Suzan

    2014-02-01

    We report a 2-year-old boy with herpes simplex virus type 1 encephalitis (HSE) and opercular syndrome who presented with clinical relapse characterized by chorea-like involuntary movements that suggest akathisia. The patient initially presented with multiple focal seizures that cause epilepsia partialis continua, polymerase chain reaction (PCR) for herpes simplex virus type 1 was positive. He developed hypersalivation, speech and swallowing difficulties within 30days. Based on these findings the patient was diagnosed as having opercular syndrome due to HSE. He developed akathisia on 44th day of admission as a relapse and he was successfully treated with propranolol. Opercular syndrome might be seen HSE in children and it may cause neurological suquela. Akathisia might be seen after encephalitic process as a symptom of relapse, however diagnosis of akathisia is difficult in young children. It should be noted that because propranolol effective for these involuntary movements. It can be add additional choice of treatment in these patients.

  7. A comparison of dental caries levels in two communities with different oral health prevention strategies stratified in different social classes.

    PubMed

    Sagheri, Darius; McLoughlin, Jacinta; Clarkson, John J

    2007-01-01

    To compare dental caries levels of schoolchildren stratified in different social classes whose domestic water supply had been fluoridated since birth (Dublin) with those living in an area where fluoridated salt was available (Freiburg). A representative, random sample of twelve-year-old children was examined and dental caries was recorded using World Health Organization criteria. A total of 699 twelve-year-old children were examined, 377 were children in Dublin and 322 in Freiburg. In Dublin the mean decayed, missing, and filled permanent teeth (DMFT) was 0.80 and in Freiburg it was 0.69. An examination of the distribution of the DMFT score revealed that its distribution is highly positively skewed. For this reason this study provides summary analyses based on medians and inter-quartile range and nonparametric rank sum tests. In both cities caries levels of children in social class 1 (highest) were considerably lower when compared with the other social classes regardless of the fluoride intervention model used. The caries levels showed a reduced disparity between children in social class 2 (medium) and 3 (lowest) in Dublin compared with those in social class 2 and 3 in Freiburg. The evidence from this study confirmed that water fluoridation has reduced the gap in dental caries experience between medium and lower social classes in Dublin compared with the greater difference in caries experience between the equivalent social classes in Freiburg. The results from this study established the important role of salt fluoridation where water fluoridation is not feasible.

  8. Physiological and Molecular Responses of Lactuca sativa to Colonization by Salmonella enterica Serovar Dublin▿

    PubMed Central

    Klerks, M. M.; van Gent-Pelzer, M.; Franz, E.; Zijlstra, C.; van Bruggen, A. H. C.

    2007-01-01

    This paper describes the physiological and molecular interactions between the human-pathogenic organism Salmonella enterica serovar Dublin and the commercially available mini Roman lettuce cv. Tamburo. The association of S. enterica serovar Dublin with lettuce plants was first determined, which indicated the presence of significant populations outside and inside the plants. The latter was evidenced from significant residual concentrations after highly efficient surface disinfection (99.81%) and fluorescence microscopy of S. enterica serovar Dublin in cross sections of lettuce at the root-shoot transition region. The plant biomass was reduced significantly compared to that of noncolonized plants upon colonization with S. enterica serovar Dublin. In addition to the physiological response, transcriptome analysis by cDNA amplified fragment length polymorphism analysis also provided clear differential gene expression profiles between noncolonized and colonized lettuce plants. From these, generally and differentially expressed genes were selected and identified by sequence analysis, followed by reverse transcription-PCR displaying the specific gene expression profiles in time. Functional grouping of the expressed genes indicated a correlation between colonization of the plants and an increase in expressed pathogenicity-related genes. This study indicates that lettuce plants respond to the presence of S. enterica serovar Dublin at physiological and molecular levels, as shown by the reduction in growth and the concurrent expression of pathogenicity-related genes. In addition, it was confirmed that Salmonella spp. can colonize the interior of lettuce plants, thus potentially imposing a human health risk when processed and consumed. PMID:17513585

  9. Enhanced viral clearance and reduced leukocyte infiltration in experimental herpes encephalitis after intranasal infection of CXCR3-deficient mice.

    PubMed

    Zimmermann, J; Hafezi, W; Dockhorn, A; Lorentzen, Eva U; Krauthausen, M; Getts, Daniel R; Müller, M; Kühn, Joachim E; King, Nicholas J C

    2017-01-23

    Herpes simplex virus type 1 (HSV-1) encephalitis (HSE) is the most common fatal sporadic encephalitis in developed countries. There is evidence from HSE animal models that not only direct virus-mediated damage caused but also the host's immune response contributes to the high mortality of the disease. Chemokines modulate and orchestrate this immune response. Previous experimental studies in HSE models identified the chemokine receptor CXCR3 and its ligands as molecules with a high impact on the course of HSE in mouse models. In this study, the role of the chemokine receptor CXCR3 was evaluated after intranasal infection with the encephalitogenic HSV-1 strain 17 syn(+) using CXCR3-deficient mice (CXCR3(-/-)) and wild-type controls. We demonstrated a neurotropic viral spread into the CNS of after intranasal infection. Although viral load and histological distribution of infected neurons were independent from CXCR3 signaling early after infection, CXCR3-deficient mice cleared HSV-1 more efficiently 14 days after infection. Furthermore, CXCR3 deficiency led to a decreased weight loss in mice after HSV-1 infection. T cell infiltration and microglial activation was prominently reduced by inhibition of CXCR3 signaling. Quantitative PCR of proinflammatory cytokines and chemokines confirmed the reduced neuroinflammatory response in CXCR3-deficient mice during HSE. Our results demonstrate that the recruitment of peripheral immune cells into the CNS, induction of neuroinflammation, and consecutive weight loss during herpes encephalitis is modulated by CXCR3 signaling. Interruption of the CXCR3 pathway ameliorates the detrimental host immune response and in turn, leads paradoxically to an enhanced viral clearance after intranasal infection. Our data gives further insight into the role of CXCR3 during HSE after intranasal infection.

  10. A simple data base for identification of risk profiles

    SciTech Connect

    Munganahalli, D.

    1996-12-31

    Sedco Forex is a drilling contractor that operates approximately 80 rigs on land and offshore worldwide. The HSE management system developed by Sedco Forex is an effort to prevent accidents and minimize losses. An integral part of the HSE management system is establishing risk profiles and thereby minimizing risk and reducing loss exposures. Risk profiles are established based on accident reports, potential accident reports and other risk identification reports (RIR) like the Du Pont STOP system. A rig could fill in as many as 30 accident reports, 30 potential accident reports and 500 STOP cards each year. Statistics are important for an HSE management system, since they are indicators of success or failure of HSE systems. It is however difficult to establish risk profiles based on statistical information, unless tools are available at the rig site to aid with the analysis. Risk profiles are then used to identify important areas in the operation that may require specific attention to minimize the loss exposure. Programs to address the loss exposure can then be identified and implemented with either a local or corporate approach. In January 1995, Sedco Forex implemented a uniform HSE Database on all the rigs worldwide. In one year companywide, the HSE database would contain information on approximately 500 accident and potential accident reports, and 10,000 STOP cards. This paper demonstrates the salient features of the database and describes how it has helped in establishing key risk profiles. It also shows a recent example of how risk profiles have been established at the corporate level and used to identify the key contributing factors to hands and finger injuries. Based on this information, a campaign was launched to minimize the frequency of occurrence and associated loss attributed to hands and fingers accidents.

  11. Attenuated kallikrein-related peptidase activity disrupts desquamation and leads to stratum corneum thickening in human skin equivalent models.

    PubMed

    McGovern, J A; Meinert, C; de Veer, S J; Hollier, B G; Parker, T J; Upton, Z

    2017-01-01

    Epidermal homeostasis is maintained through the balance between keratinocyte proliferation, differentiation and desquamation; however, human skin equivalent (HSE) models are known to differentiate excessively. In native tissue, proteases such as kallikrein-related peptidase (KLK) 5 and KLK7 cleave the extracellular components of corneodesmosomes; proteins corneodesmosin, desmocollin 1 and desmoglein 1, loosening the cellular connections and enabling desquamation. The actions of KLK7 are tightly controlled by protease inhibitors, skin-derived antileucoproteinase (SKALP) and lymphoepithelial Kazal-type-related inhibitor (LEKTI), which also inhibits KLK5, localizing protease activity to the stratum corneum. To investigate the mechanisms that inhibit the desquamation cascade in HSE models. Human skin tissue and HSE models were investigated using gene microarray, real-time polymerase chain reaction (PCR), immunohistochemistry and Western blot analysis to examine key components of the desquamation pathway. To elucidate proteolytic activity in HSEs and native skin, in situ and gel zymography was performed. Histological analysis indicated that HSE models form a well-organized epidermis, yet develop an excessively thick and compact stratum corneum. Gene microarray analysis revealed that the desquamation cascade was dysregulated in HSE models and this was confirmed using real-time PCR and immunohistochemistry. Immunohistochemistry and Western blot indicated overexpression of LEKTI and SKALP in HSEs. Although KLK7 was also highly expressed in HSEs, zymography indicated that protease activation and activity was lower than in native skin. These findings demonstrate that stratum corneum thickening is due to inhibited KLK5 and KLK7 activation and a subsequent lack of corneodesmosome degradation in the HSE model epidermis. © 2016 British Association of Dermatologists.

  12. A strategic management model for evaluation of health, safety and environmental performance.

    PubMed

    Abbaspour, Majid; Toutounchian, Solmaz; Roayaei, Emad; Nassiri, Parvin

    2012-05-01

    Strategic health, safety, and environmental management system (HSE-MS) involves systematic and cooperative planning in each phase of the lifecycle of a project to ensure that interaction among the industry group, client, contractor, stakeholder, and host community exists with the highest level of health, safety, and environmental standard performances. Therefore, it seems necessary to assess the HSE-MS performance of contractor(s) by a comparative strategic management model with the aim of continuous improvement. The present Strategic Management Model (SMM) has been illustrated by a case study and the results show that the model is a suitable management tool for decision making in a contract environment, especially in oil and gas fields and based on accepted international standards within the framework of management deming cycle. To develop this model, a data bank has been created, which includes the statistical data calculated by converting the HSE performance qualitative data into quantitative values. Based on this fact, the structure of the model has been formed by defining HSE performance indicators according to the HSE-MS model. Therefore, 178 indicators have been selected which have been grouped into four attributes. Model output provides quantitative measures of HSE-MS performance as a percentage of an ideal level with maximum possible score for each attribute. Defining the strengths and weaknesses of the contractor(s) is another capability of this model. On the other hand, this model provides a ranking that could be used as the basis for decision making at the contractors' pre-qualification phase or during the execution of the project.

  13. Warm Dense Matter Demonstrating Non-Drude Conductivity from Observations of Nonlinear Plasmon Damping

    NASA Astrophysics Data System (ADS)

    Witte, B. B. L.; Fletcher, L. B.; Galtier, E.; Gamboa, E.; Lee, H. J.; Zastrau, U.; Redmer, R.; Glenzer, S. H.; Sperling, P.

    2017-06-01

    We present simulations using finite-temperature density-functional-theory molecular dynamics to calculate the dynamic electrical conductivity in warm dense aluminum. The comparison between exchange-correlation functionals in the Perdew-Burke-Enzerhof and Heyd-Scuseria-Enzerhof (HSE) approximation indicates evident differences in the density of states and the dc conductivity. The HSE calculations show excellent agreement with experimental Linac Coherent Light Source x-ray plasmon scattering spectra revealing plasmon damping below the widely used random phase approximation. These findings demonstrate non-Drude-like behavior of the dynamic conductivity that needs to be taken into account to determine the optical properties of warm dense matter.

  14. Effects of maternal plane of nutrition and increased dietary selenium in first-parity ewes on inflammatory response in the ovine neonatal gut.

    PubMed

    Wang, H; Zhao, J; Huang, Y; Yan, X; Meyer, A M; Du, M; Vonnahme, K A; Reynolds, L P; Caton, J S; Zhu, M J

    2012-01-01

    Many areas of the western United States have soils that have increased Se content, and ruminants grazing these rangelands may ingest increased quantities of Se. In addition, high-energy diets or increased Se intake may induce gut inflammation. The objective of this study was to evaluate the effects of maternal plane of nutrition and increased dietary Se during gestation on inflammatory responses in neonatal lamb ileal tissue, a major immune organ. Rambouillet ewes (age = 240 ± 17 d; initial BW = 52.1 ± 6.2 kg) were allocated to 4 treatments arranged in a 2 × 2 factorial. Factors included Se [adequate Se (ASe, 11.5 µg/kg of BW) or high Se (HSe, 77.0 µg/kg of BW)] initiated at breeding, and nutritional plane [100% (CON) or 140% (HIH) of requirements] initiated at d 40 of gestation. Ewes were fed individually from d 40, and lambs were removed at parturition and fed artificial colostrum and milk replacer. Lambs were necropsied at 20 d of age, and ileal tissues were sampled for immunoblotting and real-time quantitative reverse-transcription PCR analyses. The ASe-HIH and HSe-CON treatments had no effect (P = 0.179) on inflammatory signaling compared with ASe-CON. However, greater inflammatory signaling was detected in the HSe-HIH group, as shown by increased (P < 0.05) mRNA expression of tumor necrosis factor-α and chemotaxis IL-8. Consistently, phosphorylation of c-Jun N-terminal kinase, a primary inflammatory signaling mediator, was greater (P < 0.05) in the HSe-HIH group compared with other treatments. Consistent with cytokine expression, mast cell density was less in the HSe-CON group than in other treatments. The expression of transforming growth factor β mRNA was greater (P < 0.05) in the HSe-HIH group; consistently, collagen content was increased in the HSe-HIH group compared with the ASe-CON group (P < 0.05). In conclusion, independently, neither HSe nor HIH had major effects on inflammation, but in combination, these maternal treatments induced an

  15. Hibiscus sabdariffa ethanolic extract protects against dyslipidemia and oxidative stress induced by chronic cholesterol administration in rabbits.

    PubMed

    Ekor, M; Adesanoye, O A; Udo, I E; Adegoke, O A; Raji, J; Farombi, E O

    2010-12-01

    Excessive intake of cholesterol (CHOL) and induction of free radical production play a critical role in the pathophysiology of several human diseases. Dietary therapy with plant products rich in flavonoids has been shown to provide benefits without the adverse effects of agents used in clinical practice. Hibiscus sabdariffa (HS) has been used for various purposes due to myriads of flavonoids present in it. In this study, the chemopreventive property of HS ethanolic extract (HSE) was investigated in dyslipidemia and oxidant stress associated with prolonged CHOL administration in rabbits. Twenty-five (25) adult male rabbits weighing between 1.5 and 1.7 kg were used and randomly divided into five groups of five rabbits per group. The CHOL-fed rabbits received 1 g/kg/day of CHOL suspended in 1 ml of corn oil for 8 weeks. Group 1 received 1 ml of corn oil and served as control. Group 2 was fed with CHOL only while groups 3, 4 and 5 received daily doses ofcholestyramine (questran, 260 mg/kg), HSE 200 mg/kg and HSE 300 mg/kg respectively along with CHOL. Animals were sacrificed by cervical dislocation 24-hours after last dose. Enzymic and non-enzymic markers of oxidative stress and lipid profile were analysed in serum, liver, kidney and heart of rabbits. HSE significantly attenuated the alteration in lipid levels and antioxidant status induced by high CHOL intake in rabbits in this study. Both serum and tissue levels of low density lipoprotein-CHOL, triglycerides, phospholipids, and total CHOL decreased with increase in high density lipoprotein-CHOL except in the heart, following treatment with HSE in CHOL-fed rabbits when compared with the untreated group (p<0.05). Similarly, HSE prevented CHOL-induced depletion of enzymic (superoxide dismutase, catalase) and non-enzymic (reduced glutathione, vitamin C) antioxidants with the attendant increases in lipid peroxidation and xanthine oxidase activity in these animals. The effectiveness of HSE in this condition was comparable

  16. Prolonged acyclovir treatment in a child with opercular syndrome related to herpes simplex encephalitis.

    PubMed

    Karli, Arzu; Şensoy, Gülnar; Tekin, Emine; Sofuoğlu, Ayşe I; Bilgici, Meltem C; Özyürek, Hamit

    HSV 1 encephalitis is the most common cause of sporadic and focal viral encephalitis. Opercular syndrome is characterized by swallowing and speech difficulties which are associated with deterioration of voluntary control of face, pharynx, tongue and chewing muscles. It can be developed in patients with Herpes simplex encephalitis (HSE). Here, a twelve-year-old boy who was diagnosed with HSE and Opercular syndrome, is presented. The patient recovered without sequela as a result of 30 days of intravenous and 10 days of oral acyclovir treatment. It might be important as well, to personalize and elongate the treatment in terms of prognosis.

  17. Improved CT Detection of Acute Herpes Simplex Virus Type 1 Encephalitis Based on a Frequency-Selective Nonlinear Blending: Comparison With MRI.

    PubMed

    Bongers, Malte Niklas; Bier, Georg; Ditt, Hendrik; Beck, Robert; Ernemann, Ulrike; Nikolaou, Konstantin; Horger, Marius

    2016-11-01

    The purpose of this study is to compare the diagnostic efficacy of a new CT postprocessing tool based on frequency-selective nonlinear blending (best-contrast CT) with that of standard linear blending of unenhanced head CT in patients with herpes simplex virus type 1 and herpes simplex virus encephalitis (HSE), using FLAIR MRI sequences as the standard of reference. Fifteen consecutive patients (six women and nine men; mean [± SD] age, 60 ± 19 years) with proven HSE (positive polymerase chain reaction results from CSF analysis and the presence of neurologic deficits) were retrospectively enrolled. All patients had undergone head CT and MRI (mean time interval, 2 ± 2 days). After standardized unenhanced head CT scans were read, presets of the best-contrast algorithm were determined (center, 30 HU; delta, 5 HU; slope, 5 nondimensional), and resulting images were analyzed. Contrast enhancement was objectively measured by ROI analysis, comparing contrast-to-noise ratios (CNRs) of unenhanced CT and best-contrast CT. FLAIR and DWI MRI sequences were analyzed, and FLAIR was considered as the standard of reference. For assessment of disease extent, a previously reported 50-point score (HSE score) was used. CNR values for unenhanced head CT (CNR, 5.42 ± 2.77) could be statistically significantly increased using best-contrast CT (CNR, 9.62 ± 4.28) (p = 0.003). FLAIR sequences yielded a median HSE score of 9.0 (range, 6-17) and DWI sequences yielded HSE scores of 6.0 (range, 5-17). By comparison, unenhanced head CT resulted in a median HSE score of 3.5 (range, 1-6). The median best-contrast CT HSE score was 7.5 (range, 6-10). Agreement between FLAIR and unenhanced CT was 54.44%, that between DWI and best-contrast CT was 95.36%, and that between FLAIR and best-contrast CT was 85.21%. The most frequently overseen findings were located at the level of the upper part of the mesencephalon and at the subthalamic or insular level. Frequency-selective nonlinear blending

  18. TLR3 deficiency in herpes simplex encephalitis

    PubMed Central

    Lim, Hye Kyung; Seppänen, Mikko; Hautala, Timo; Ciancanelli, Michael J.; Itan, Yuval; Lafaille, Fabien G.; Dell, William; Lorenzo, Lazaro; Byun, Minji; Pauwels, Elodie; Rönnelid, Ylva; Cai, Xin; Boucherit, Soraya; Jouanguy, Emmanuelle; Paetau, Anders; Lebon, Pierre; Rozenberg, Flore; Tardieu, Marc; Abel, Laurent; Yildiran, Alisan; Vergison, Anne; Roivainen, Reina; Etzioni, Amos; Tienari, Pentti J.

    2014-01-01

    Objective: To determine the proportion of children with herpes simplex encephalitis (HSE) displaying TLR3 deficiency, the extent of TLR3 allelic heterogeneity, and the specific clinical features of TLR3 deficiency. Methods: We determined the sequence of all exons of TLR3 in 110 of the 120 patients with HSE enrolled in our study who do not carry any of the previously described HSE-predisposing mutations of TLR3 pathway genes (TLR3, UNC93B1, TRIF, TRAF3, and TBK1). All the new mutant TLR3 alleles detected were characterized experimentally in-depth to establish the causal relationship between the genotype and phenotype. Results: In addition to the 3 previously reported TLR3-deficient patients from the same cohort, 6 other children or young adults with HSE carry 1 of 5 unique or extremely rare (minor allele frequency <0.001) missense TLR3 alleles. Two alleles (M374T, D592N) heterozygous in 3 patients are not deleterious in vitro. The other 3 are deleterious via different mechanisms: G743D+R811I and L360P heterozygous in 2 patients are loss-of-function due to low levels of expression and lack of cleavage, respectively, and R867Q homozygous in 1 patient is hypomorphic. The 3 patients' fibroblasts display impaired TLR3 responses and enhanced herpes simplex virus 1 susceptibility. Overall, TLR3 deficiency is therefore found in 6 (5%) of the 120 patients studied. There is high allelic heterogeneity, with 3 forms of autosomal dominant partial defect by negative dominance or haploinsufficiency, and 2 forms of autosomal recessive defect with complete or partial deficiency. Finally, 4 (66%) of the 6 TLR3-deficient patients had at least 1 late relapse of HSE, whereas relapse occurred in only 12 (10%) of the total cohort of 120 patients. Conclusions: Childhood-onset HSE is due to TLR3 deficiency in a traceable fraction of patients, in particular the ones with HSE recurrence. Mutations in TLR3 and TLR3 pathway genes should be searched and experimentally studied in children with

  19. "Their pineal glands aglow": Theosophical physiology in Ulysses.

    PubMed

    Morrisson, Mark S

    2008-01-01

    This article argues that Joyce's engagements with the Theosophy of the Dublin literary world amount to more than simple parody. In Ulysses, Joyce portrays Theosophy's efforts to offer an alternative understanding of physiology to that of the medical establishment as a form of boundary work, an adaptation of the discourse of modern medical research to fashion modern mysticism as a science. Ultimately, Joyce rejects Theosophical physiology and its evolutionary scientism because it provides an unsatisfactory rhetorical body, a failed attempt to renegotiate the boundaries between scientific materialism and spirituality in the awkward modernity of Dublin in 1904.

  20. Partitioning of Pd Between Fe-S-C and Mantle Liquids at High Pressure and Temperature: Implications for Core Formation

    NASA Technical Reports Server (NTRS)

    Righter, K.; Humayun, M.; Danielson, L.

    2007-01-01

    One of the most elusive geochemical aspects of the early Earth has been explaining the near chondritic relative abundances of the highly siderophile elements (HSE; Au, Re and the platinum group elements) in Earth's primitive upper mantle (PUM). Perhaps they were delivered to the Earth after core formation, by late addition of carbonaceous chondrite material. However, the recognition that many moderately siderophile elements can be explained by high pressure and temperature (PT) metal-silicate equilibrium, leads to the question whether high PT equilibrium can also explain the HSE concentrations. Answers to this question have been slowed by experimental difficulties (nugget effect and very low solubilities). But two different perspectives have emerged from recent studies. One perspective is that D(M/S) for HSE at high PT are not low enough to explain terrestrial mantle depletions of these elements (for Pd and Pt). A second perspective is D(M/S) are reduced substantially at high PT and even low enough to explain terrestrial mantle depletions (for Au and Pt). Issues complicating interpretation of all experiments include use of MgO- and FeO-free silicate melts, and S-free and FeNi metal-free systems. In addition, conclusions for Pt rest on an interpretation that the tiny metallic nuggets plaguing many such experiments, were formed upon quench. There is not agreement on this issue, and the general question of HSE solubility at high PT remains unresolved

  1. Sexual Health Promotion Programme: Participants' Perspectives on Capacity Building

    ERIC Educational Resources Information Center

    Keogh, Brian; Daly, Louise; Sharek, Danika; De Vries, Jan; McCann, Edward; Higgins, Agnes

    2016-01-01

    Objectives: The aim of this study was to evaluate a Health Service Executive (HSE) Foundation Programme in Sexual Health Promotion (FPSHP) with a specific emphasis on capacity building. Design: A mixed-method design using both quantitative and qualitative methods was used to collect the data. Setting: The FPSHP was delivered to staff working in…

  2. Late Influx: Evidence from Siderophile Elements in Terrestrial Peridotites and Lunar Breccias

    NASA Technical Reports Server (NTRS)

    Morgan, J. W.; Brandon, A. D.; Walker, R. J.; Horan, M. F.

    2001-01-01

    In terrestrial peridotites, Pd is sometimes enhanced relative to other PGE. This observation is taken to imply a "non-chondritic" HSE signature in the mantle. A similar pattern is seen in some Apollo 17 breccias suggesting it to be a primordial feature of late influx. Additional information is contained in the original extended abstract.

  3. Chronic cortical and subcortical pathology with associated neurological deficits ensuing experimental herpes encephalitis.

    PubMed

    Armien, Anibal G; Hu, Shuxian; Little, Morgan R; Robinson, Nicholas; Lokensgard, James R; Low, Walter C; Cheeran, Maxim C-J

    2010-07-01

    Long-term neurological sequela is common among herpes simplex encephalitis (HSE) survivors. Animal models for HSE are used to investigate mechanisms of acute disease, but little has been done to model chronic manifestations of HSE. The current study presents a detailed, systematic analysis of chronic neuropathology, including characterization of topography and sequential progression of degenerative lesions and inflammation. Subsequent to intranasal HSV-1 infection, inflammatory responses that were temporally and spatially distinct persisted in infected cortical and brain stem regions. Neutrophils were present exclusively within the olfactory bulb and brain stem regions during the acute phase of infection, while the chronic inflammation was marked by plasma cells, lymphocytes and activated microglia. The chronic lymphocytic infiltrate, cytokine production, and activated microglia were associated with the loss of cortical neuropile in the entorhinal cortex and hippocampus. Animals surviving the acute infection showed a spectrum of chronic lesions from decreased brain volume, neuronal loss, activated astrocytes, and glial scar formation to severe atrophy and cavitations of the cortex. These lesions were also associated with severe spatial memory deficits in surviving animals. Taken together, this model can be utilized to further investigate the mechanisms of neurological defects that follow in the wake of HSE.

  4. Aqueous Extract from Hibiscus sabdariffa Linnaeus Ameliorate Diabetic Nephropathy via Regulating Oxidative Status and Akt/Bad/14-3-3γ in an Experimental Animal Model

    PubMed Central

    Wang, Shou-Chieh; Lee, Shiow-Fen; Wang, Chau-Jong; Lee, Chao-Hsin; Lee, Wen-Chin; Lee, Huei-Jane

    2011-01-01

    Several studies point out that oxidative stress maybe a major culprit in diabetic nephropathy. Aqueous extract of Hibiscus sabdariffa L. (HSE) has been demonstrated as having beneficial effects on anti-oxidation and lipid-lowering in experimental studies. This study aimed at investigating the effects of Hibiscus sabdariffa L. on diabetic nephropathy in streptozotocin induced type 1 diabetic rats. Our results show that HSE is capable of reducing lipid peroxidation, increasing catalase and glutathione activities significantly in diabetic kidney, and decreasing the plasma levels of triglyceride, low-density lipoprotein (LDL) and increasing high-density lipoprotein (HDL) value. In histological examination, HSE improves hyperglycemia-caused osmotic diuresis in renal proximal convoluted tubules (defined as hydropic change) in diabetic rats. The study also reveals that up-regulation of Akt/Bad/14-3-3γ and NF-κB-mediated transcription might be involved. In conclusion, our results show that HSE possesses the potential effects to ameliorate diabetic nephropathy via improving oxidative status and regulating Akt/Bad/14-3-3γ signaling. PMID:19965962

  5. Semantic Development in Spanish-English Bilingual Children: Effects of Age and Language Experience

    ERIC Educational Resources Information Center

    Sheng, Li; Bedore, Lisa M.; Pena, Elizabeth D.; Fiestas, Christine

    2013-01-01

    This study examines semantic development in 60 Spanish-English bilingual children, ages 7 years 3 months to 9 years 11 months, who differed orthogonally in age (younger, older) and language experience (higher English experience [HEE], higher Spanish experience [HSE]). Children produced 3 associations to 12 pairs of translation equivalents. Older…

  6. Functional IRF3 deficiency in a patient with herpes simplex encephalitis

    PubMed Central

    Andersen, Line Lykke; Mørk, Nanna; Reinert, Line S.; Kofod-Olsen, Emil; Narita, Ryo; Jørgensen, Sofie E.; Skipper, Kristian A.; Höning, Klara; Gad, Hans Henrik; Østergaard, Lars; Ørntoft, Torben F.; Hornung, Veit; Paludan, Søren R.; Mikkelsen, Jacob Giehm; Fujita, Takashi; Christiansen, Mette; Hartmann, Rune

    2015-01-01

    Herpes simplex encephalitis (HSE) in children has previously been linked to defects in type I interferon (IFN) production downstream of Toll-like receptor 3. Here, we describe a novel genetic etiology of HSE by identifying a heterozygous loss-of-function mutation in the IFN regulatory factor 3 (IRF3) gene, leading to autosomal dominant (AD) IRF3 deficiency by haploinsufficiency, in an adolescent female patient with HSE. IRF3 is activated by most pattern recognition receptors recognizing viral infections and plays an essential role in induction of type I IFN. The identified IRF3 R285Q amino acid substitution results in impaired IFN responses to HSV-1 infection and particularly impairs signaling through the TLR3–TRIF pathway. In addition, the R285Q mutant of IRF3 fails to become phosphorylated at S386 and undergo dimerization, and thus has impaired ability to activate transcription. Finally, transduction with WT IRF3 rescues the ability of patient fibroblasts to express IFN in response to HSV-1 infection. The identification of IRF3 deficiency in HSE provides the first description of a defect in an IFN-regulating transcription factor conferring increased susceptibility to a viral infection in the CNS in humans. PMID:26216125

  7. 78 FR 55230 - Safety and Environmental Management System Requirements for Vessels on the U.S. Outer Continental...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-10

    ... International Standards Organization 9001 (ISO 9001:2008). The Coast Guard is currently researching whether... IADC HSE Case, ISO 9001:2008, or any other performance-based safety management alternatives or..., work practices, management-of-change procedures, and associated training. The SEMS would also...

  8. Density functional theory study of the electronic structure of fluorite Cu2Se

    NASA Astrophysics Data System (ADS)

    Råsander, Mikael; Bergqvist, Lars; Delin, Anna

    2013-03-01

    We have investigated the electronic structure of fluorite Cu2Se using density functional theory calculations within the LDA, PBE and AM05 approximations as well as the non-local hybrid PBE0 and HSE approximations. We find that Cu2Se is a zero gap semiconductor when using either a local or semi-local density functional approximation while the PBE0 functional opens up a gap. For the HSE approximation, we find that the presence of a gap depends on the range separation for the non-local exchange. For the occupied part in the density of states we find that LDA, PBE, AM05, PBE0 and HSE agree with regard to the overall electronic structure. However, the hybrid functionals result in peaks shifted towards lower energy compared to LDA, PBE and AM05. The valence bands obtained using the hybrid functionals are in good agreement with experimental valence band spectra. We also find that the PBE, PBE0 and HSE approximations give similar results regarding bulk properties, such as lattice constants and bulk modulus. In addition, we have investigated the localization of the Cu d-states and its effect on the band gap in the material using the LDA + U approach. We find that a sufficiently high U indeed opens up a gap; however, this U leads to valence bands that disagree with experimental observations.

  9. Enhancing self-efficacy improves episodic future thinking and social-decision making in combat veterans with posttraumatic stress disorder.

    PubMed

    Brown, Adam D; Kouri, Nicole A; Rahman, Nadia; Joscelyne, Amy; Bryant, Richard A; Marmar, Charles R

    2016-08-30

    Posttraumatic Stress Disorder (PTSD) is associated with maladaptive changes in self-identity, including impoverished perceived self-efficacy. This study examined if enhancing perceptions of self-efficacy in combat veterans with and without symptoms of PTSD promotes cognitive strategies associated with positive mental health outcomes. Prior to completing a future thinking and social problem-solving task, sixty-two OEF/OIF veterans with and without symptoms of PTSD were randomized to either a high self-efficacy (HSE) induction in which they were asked to recall three autobiographical memories demonstrating self-efficacy or a control condition in which they recalled any three autobiographical events. An interaction between HSE and PTSD revealed that individuals with symptoms of PTSD in the HSE condition generated future events with more self-efficacious statements than those with PTSD in the control condition, whereas those without PTSD did not differ in self-efficacy content across the conditions. In addition, individuals in the HSE condition exhibited better social problem solving than those in the control condition. Increasing perceptions of self-efficacy may promote future thinking and problem solving in ways that are relevant to overcoming trauma and adversity.

  10. Nonlinear electronic excitations in crystalline solids using meta-generalized gradient approximation and hybrid functional in time-dependent density functional theory.

    PubMed

    Sato, Shunsuke A; Taniguchi, Yasutaka; Shinohara, Yasushi; Yabana, Kazuhiro

    2015-12-14

    We develop methods to calculate electron dynamics in crystalline solids in real-time time-dependent density functional theory employing exchange-correlation potentials which reproduce band gap energies of dielectrics; a meta-generalized gradient approximation was proposed by Tran and Blaha [Phys. Rev. Lett. 102, 226401 (2009)] (TBm-BJ) and a hybrid functional was proposed by Heyd, Scuseria, and Ernzerhof [J. Chem. Phys. 118, 8207 (2003)] (HSE). In time evolution calculations employing the TB-mBJ potential, we have found it necessary to adopt the predictor-corrector step for a stable time evolution. We have developed a method to evaluate electronic excitation energy without referring to the energy functional which is unknown for the TB-mBJ potential. For the HSE functional, we have developed a method for the operation of the Fock-like term in Fourier space to facilitate efficient use of massive parallel computers equipped with graphic processing units. We compare electronic excitations in silicon and germanium induced by femtosecond laser pulses using the TB-mBJ, HSE, and a simple local density approximation (LDA). At low laser intensities, electronic excitations are found to be sensitive to the band gap energy: they are close to each other using TB-mBJ and HSE and are much smaller in LDA. At high laser intensities close to the damage threshold, electronic excitation energies do not differ much among the three cases.

  11. Fatal herpetic encephalitis during brain radiotherapy in a cerebral metastasized breast cancer patient.

    PubMed

    Koudriavtseva, Tatiana; Onesti, Emanuela; Tonachella, Riccardo; Pelagalli, Lorella; Vidiri, Antonello; Jandolo, Bruno

    2010-10-01

    Herpes simplex encephalitis (HSE) is a life-threatening condition with high mortality. The pathogenesis underlying the reactivation of latent herpes simplex virus (HSV) remains undefined. We present the case of a 55-year-old female who developed HSE type 1 during brain irradiation and antioedematous dexamethasone treatment for leptomeningeal metastasized breast tumor with epileptic seizures. During the radiotherapy (RT), after a total of 32 Gray administrated in 16 fractions, our patient developed cognitive impairment and partial epileptic status without fever. Two days later the patient's clinical conditions had deteriorated and high fever manifested. A diagnosis of HSE type 1 was made by a positive cerebrospinal fluid polymerase chain reaction. Antiviral therapy with high doses of acyclovir was practiced for four weeks but the comatose state persisted. The patient died 59 days after the last RT fraction. The temporal relationship of RT to the occurrence of HSE suggests that cranial irradiation may play a role in the reactivation of latent HSV. Although antiviral therapy resistance is infrequent in immunocompetent patients, it is one of the main problems in immunocompromized patients.

  12. Academic Professionalism in the Era of Change: Role Subidentities and Transformation of Time Budgets

    ERIC Educational Resources Information Center

    Abramov, Roman Nikolaevich; Gruzdev, Ivan Andreevich; Terentyev, Evgeny Andreevich

    2016-01-01

    This article is based on a case study conducted within the National Research University Higher School of Economics (NRU HSE) that examined the identity fragmentation of academic professionals in the context of current educational and academic reforms in Russia. Seven hundred and five professors were surveyed for the study, which focused on…

  13. New Openings in University-Industry Cooperation: Aalto University as the Forerunner of European University Reform

    ERIC Educational Resources Information Center

    Markkula, Markku; Lappalainen, Pia

    2009-01-01

    The Innovation University (IU)--to be called the Aalto University after Alvav Aalto, a famous Finnish architect and MIT professor--is a new university which will be created through a merger of three existing universities: the Helsinki University of Technology (TKK), the Helsinki School of Economics (HSE) and the University of Art and Design…

  14. Predictors of a health-promoting lifestyle and behaviors among low-income African American mothers and white mothers of chronically ill children.

    PubMed

    Tucker, Carolyn M; Butler, Ashley M; Loyuk, Imicuk S; Desmond, Frederic F; Surrency, Sharon L

    2009-02-01

    This study used Health Self-Empowerment (HSE) Theory as a framework for examining the predictors of engagement in both a health-promoting lifestyle and individual health-promoting behaviors among low-income African American mothers and non-Hispanic white mothers (N = 96), each of whom is the primary caregiver for a chronically ill adolescent. The individual health-promoting behaviors investigated are eating a healthy diet, exercising consistently, stress management practices, and health responsibility behaviors. The examined HSE Theory-based predictor variables were health self-efficacy, active coping, health motivation, and health self-praise. Multiple regression analyses revealed that these predictor variables together accounted for a significant amount of variance (67%) in level of engagement in a health-promoting lifestyle. Additionally, active coping, health self-praise, health self-efficacy, and health motivation were significant individual predictors of 1 or more individual health-promoting behaviors. Findings from this study suggest that further research should be conducted to assess the usefulness of HSE Theory in predicting level of engagement in health-promoting behaviors and to examine the effectiveness of HSE Theory-based interventions for increasing health-promoting behaviors among women similar to those in this study. The findings also suggest that health care providers should promote active coping, health self-praise, health self-efficacy, and health motivation to increase health-promoting behaviors among patients who are similar to those in this study.

  15. When Density Functional Approximations Meet Iron Oxides.

    PubMed

    Meng, Yu; Liu, Xing-Wu; Huo, Chun-Fang; Guo, Wen-Ping; Cao, Dong-Bo; Peng, Qing; Dearden, Albert; Gonze, Xavier; Yang, Yong; Wang, Jianguo; Jiao, Haijun; Li, Yongwang; Wen, Xiao-Dong

    2016-10-11

    Three density functional approximations (DFAs), PBE, PBE+U, and Heyd-Scuseria-Ernzerhof screened hybrid functional (HSE), were employed to investigate the geometric, electronic, magnetic, and thermodynamic properties of four iron oxides, namely, α-FeOOH, α-Fe2O3, Fe3O4, and FeO. Comparing our calculated results with available experimental data, we found that HSE (a = 0.15) (containing 15% "screened" Hartree-Fock exchange) can provide reliable values of lattice constants, Fe magnetic moments, band gaps, and formation energies of all four iron oxides, while standard HSE (a = 0.25) seriously overestimates the band gaps and formation energies. For PBE+U, a suitable U value can give quite good results for the electronic properties of each iron oxide, but it is challenging to accurately get other properties of the four iron oxides using the same U value. Subsequently, we calculated the Gibbs free energies of transformation reactions among iron oxides using the HSE (a = 0.15) functional and plotted the equilibrium phase diagrams of the iron oxide system under various conditions, which provide reliable theoretical insight into the phase transformations of iron oxides.

  16. A pilot study of the photoprotective effect of almond phytochemicals in a 3D human skin equivalent

    USDA-ARS?s Scientific Manuscript database

    UV exposure causes oxidative stress, inflammation, erythema, and skin cancer. Alpha-Tocopherol (AT) and polyphenols (AP) present in almonds may serve as photoprotectants. Our objectives were to assess the feasibility of using a 3D human skin equivalent (HSE) in photoprotectant research and to deter...

  17. Recommendations For The Safe Design, Operation And Use Of Commercial Sun Tanning Equipment

    NASA Astrophysics Data System (ADS)

    Cox, E. A.

    1982-02-01

    HSE Guidance Notes are being prepared to give recommendations to the designers, manufacturers, operators and users of commercial sun tanning equipment on the various health and safety aspects associated with the safe construction, siting and use of such equipment. Medically prescribed ultraviolet treatments are excluded from the guidance.

  18. Density functional theory study of the electronic structure of fluorite Cu2Se.

    PubMed

    Råsander, Mikael; Bergqvist, Lars; Delin, Anna

    2013-03-27

    We have investigated the electronic structure of fluorite Cu2Se using density functional theory calculations within the LDA, PBE and AM05 approximations as well as the non-local hybrid PBE0 and HSE approximations. We find that Cu2Se is a zero gap semiconductor when using either a local or semi-local density functional approximation while the PBE0 functional opens up a gap. For the HSE approximation, we find that the presence of a gap depends on the range separation for the non-local exchange. For the occupied part in the density of states we find that LDA, PBE, AM05, PBE0 and HSE agree with regard to the overall electronic structure. However, the hybrid functionals result in peaks shifted towards lower energy compared to LDA, PBE and AM05. The valence bands obtained using the hybrid functionals are in good agreement with experimental valence band spectra. We also find that the PBE, PBE0 and HSE approximations give similar results regarding bulk properties, such as lattice constants and bulk modulus. In addition, we have investigated the localization of the Cu d-states and its effect on the band gap in the material using the LDA + U approach. We find that a sufficiently high U indeed opens up a gap; however, this U leads to valence bands that disagree with experimental observations.

  19. Customer satisfaction survey with the National Vaccine Cold Chain Delivery Service.

    PubMed

    Meara, M O; Morrissey, Y; Corcoran, B

    2009-05-01

    In 2008 the Health Service Executive (HSE) carried out a survey to assess general practitioners (GPs) satisfaction with the National Vaccine Cold Chain Service. This survey found high levels of satisfaction (> 90%) with the service. Over half of those surveyed had used the vaccine returns service with the majority (89.2%) finding it good or very good.

  20. Constitutive and heat-inducible heat shock element binding activities of heat shock factor in a group of filamentous fungi

    PubMed Central

    Xavier, Ilungo J.; Khachatourians, George G.; Ovsenek, Nick

    1999-01-01

    This study represents the initial characterization of the heat shock factor (HSF) in filamentous fungi. We demonstrate that HSFs from Beauveria bassiana, Metarhizium anisopliae, Tolypocladium nivea, Paecilomyces farinosus, and Verticillium lecanii bind to the heat shock element (HSE) constitutively (non-shocked), and that heat shock resulted in increased quantities and decreased mobility of HSF-HSE complexes. The monomeric molecular mass of both heat-induced and constitutive HSFs was determined to be 85.8 kDa by UV-crosslinking and the apparent molecular masses of the native HSF-HSE complexes as determined by pore exclusion gradient gel electrophoresis was 260 and 300 kDa, respectively. Proteolytic band clipping assays using trypsin and chymotrypsin revealed an identical partial cleavage profile for constitutive and heat-induced HSF-HSE complexes. Thus, it appears that both constitutive and heat-inducible complexes are formed by trimers composed of the same HSF molecule which undergoes conformational changes during heat shock. The mobility difference between the complexes was not abolished by enzymatic dephosphorylation and deglycosylation, indicating that the reduced mobility of the heat-induced HSF is probably due to a post-translational modification other than phosphorylation or glycosylation. PMID:10590835

  1. 45. MAIN MEETING ROOM COLUMNS. Ends of gallery columns identified ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    45. MAIN MEETING ROOM COLUMNS. Ends of gallery columns identified at the time of removal for transfer to the George School for re-erection. The stamp reads, 'REMOVED FROM 12th ST. MTG HSE PHILA 1972'. - Twelfth Street Meeting House, 20 South Twelfth Street, Philadelphia, Philadelphia County, PA

  2. A review of the use of health examination data from the Health Survey for England in government policy development and implementation.

    PubMed

    Oyebode, Oyinlola; Mindell, Jennifer S

    2014-01-01

    Information is needed at all stages of the policy making process. The Health Survey for England (HSE) is an annual cross-sectional health examination survey of the non-institutionalised general population in England. It was originally set up to inform national policy making and monitoring by the Department of Health. This paper examines how the nurse collected physical and biological measurement data from the HSE have been essential or useful for identification of a health issue amenable to policy intervention; initiation, development or implementation of a strategy; choice and monitoring of targets; or assessment and evaluation of policies. Specific examples of use of HSE data were identified through interviews with senior members of staff at the Department of Health and the Health and Social Care Information Centre. Policy documents mentioned by interviewees were retrieved for review, and reference lists of associated policy documents checked. Systematic searches of Chief Medical Officer Reports, Government 'Command Papers', and clinical guidance documents were also undertaken. HSE examination data have been used at all stages of the policy making process. Data have been used to identify an issue amenable to policy-intervention (e.g. quantifying prevalence of undiagnosed chronic kidney disease), in strategy development (in models to inform chronic respiratory disease policy), for target setting and monitoring (the 1992 blood pressure target) and in evaluation of health policy (the effect of the smoking ban on second hand smoke exposure). A health examination survey is a useful part of a national health information system.

  3. After Incarceration and Adult Learning: A Collaborative Inquiry and Writing Project

    ERIC Educational Resources Information Center

    Schwartz, Joni

    2015-01-01

    Mass incarceration in America is a moral, economic, and societal crisis with serious implications for many men of color and high school non-completers who are incarcerated at proportionally higher rates than Whites or college graduates. For the formerly incarcerated, engagement in adult learning, whether high school equivalency (HSE) or college,…

  4. Sexual Health Promotion Programme: Participants' Perspectives on Capacity Building

    ERIC Educational Resources Information Center

    Keogh, Brian; Daly, Louise; Sharek, Danika; De Vries, Jan; McCann, Edward; Higgins, Agnes

    2016-01-01

    Objectives: The aim of this study was to evaluate a Health Service Executive (HSE) Foundation Programme in Sexual Health Promotion (FPSHP) with a specific emphasis on capacity building. Design: A mixed-method design using both quantitative and qualitative methods was used to collect the data. Setting: The FPSHP was delivered to staff working in…

  5. After-School Centres: Statistical Information and Monitoring of the Economics of Education

    ERIC Educational Resources Information Center

    Kupriyanov, B. V.; Kosaretsky, S. G.; Mertsalova, T. A.; Semenova, T. V.

    2015-01-01

    This article presents results of a survey of after-school centre directors concerning the extracurricular activities of children. It was conducted within the framework of the Monitoring of the Economics of Education at the National Research University--Higher School of Economics (HSE). The demographics of students at children's after-school…

  6. Psychosocial Hazards in UK Universities: Adopting a Risk Assessment Approach

    ERIC Educational Resources Information Center

    Kinman, Gail; Court, Stephen

    2010-01-01

    Drawing on the findings of a recent national survey, this article examines the extent to which higher education institutions in the United Kingdom meet the minimum standards recommended by the Health and Safety Executive (HSE) for the management of work-related stressors. A comparison is also made between the average weekly working hours reported…

  7. Back to School: A Guide to Continuing Your Education after Prison

    ERIC Educational Resources Information Center

    Crayton, Anna; Lindahl, Nicole

    2015-01-01

    This guide is designed to help readers take the first steps towards continuing their education, whether that means learning English, working towards a High School Equivalency (HSE), learning an occupation, or building on college credits already earned. This guide walks readers through the process of setting educational goals and getting organized;…

  8. Reliability of range-separated hybrid functionals for describing magnetic coupling in molecular systems

    NASA Astrophysics Data System (ADS)

    Rivero, Pablo; Moreira, Ibério de P. R.; Illas, Francesc; Scuseria, Gustavo E.

    2008-11-01

    The performance of the Heyd-Scuseria-Ernzerhorf (HSE) and single parameter long-range corrected Perdew-Burke-Ernzerhorf (LC-ωPBE) range-separated hybrids for predicting magnetic coupling constants has been investigated for a broad set of magnetic molecular systems for which accurate experimental data exist. The set includes the H-He-H model system, two organic diradicals with different magnetic behaviors, and a series of Cu dinuclear complexes with a broad range of magnetic coupling values. Both HSE and LC-ωPBE provide a significant improvement to standard hybrids such as the well-known hybrid Becke-3-parameters exchange with Lee-Yang-Parr correlation (B3LYP) functional. Nevertheless, the performance of these two range-separated hybrid functionals is different: HSE overestimates antiferromagnetic and ferromagnetic interactions in Cu dinuclear complexes (although significantly less than B3LYP), whereas LC-ωPBE treats ferro- and antiferromagnetic couplings on a much more balanced way. The increased accuracy of LC-ωPBE suggests that the inclusion of 100% Hartree-Fock exchange considered in the definition of this long-range corrected hybrid functional has important consequences for an accurate description of exchange and correlation effects on the electronic structure of open shell systems. On the other hand, HSE, which was developed with periodic systems in mind, also performs quite well (and better than B3LYP) thus opening the possibility of magnetic coupling studies in metal oxides and other challenging solids.

  9. After Incarceration and Adult Learning: A Collaborative Inquiry and Writing Project

    ERIC Educational Resources Information Center

    Schwartz, Joni

    2015-01-01

    Mass incarceration in America is a moral, economic, and societal crisis with serious implications for many men of color and high school non-completers who are incarcerated at proportionally higher rates than Whites or college graduates. For the formerly incarcerated, engagement in adult learning, whether high school equivalency (HSE) or college,…

  10. Characterization of a Human Skin Equivalent Model to Study the Effects of Ultraviolet B Radiation on Keratinocytes

    PubMed Central

    Van Lonkhuyzen, Derek R.; Dawson, Rebecca A.; Kimlin, Michael G.; Upton, Zee

    2014-01-01

    The incidences of skin cancers resulting from chronic ultraviolet radiation (UVR) exposure are on the incline in both Australia and globally. Hence, the cellular and molecular pathways that are associated with UVR-induced photocarcinogenesis need to be urgently elucidated, in order to develop more robust preventative and treatment strategies against skin cancers. In vitro investigations into the effects of UVR (in particular, the highly mutagenic UVB wavelength) have, to date, mainly involved the use of cell culture and animal models. However, these models possess biological disparities to native skin, which, to some extent, have limited their relevance to the in vivo situation. To address this, we characterized a three-dimensional, tissue-engineered human skin equivalent (HSE) model (consisting of primary human keratinocytes cultured on a dermal-derived scaffold) as a representation of a more physiologically relevant platform to study keratinocyte responses to UVB. Significantly, we demonstrate that this model retains several important epidermal properties of native skin. Moreover, UVB irradiation of the HSE constructs was shown to induce key markers of photodamage in the HSE keratinocytes, including the formation of cyclobutane pyrimidine dimers, the activation of apoptotic pathways, the accumulation of p53, and the secretion of inflammatory cytokines. Importantly, we also demonstrate that the UVB-exposed HSE constructs retain the capacity for epidermal repair and regeneration after photodamage. Together, our results demonstrate the potential of this skin equivalent model as a tool to study various aspects of the acute responses of human keratinocytes to UVB radiation damage. PMID:24219750

  11. New Openings in University-Industry Cooperation: Aalto University as the Forerunner of European University Reform

    ERIC Educational Resources Information Center

    Markkula, Markku; Lappalainen, Pia

    2009-01-01

    The Innovation University (IU)--to be called the Aalto University after Alvav Aalto, a famous Finnish architect and MIT professor--is a new university which will be created through a merger of three existing universities: the Helsinki University of Technology (TKK), the Helsinki School of Economics (HSE) and the University of Art and Design…

  12. High School Equivalency Testing in Arizona. Forum: Responding to Changes in High School Equivalency Testing

    ERIC Educational Resources Information Center

    Hart, Sheryl

    2015-01-01

    For decades, the state of Arizona has used the General Educational Development (GED) Test to award the Arizona High School Equivalency (HSE) Diploma, as the GED Test was the only test available, recognized and accepted in the United States as the measure by which adults could demonstrate the educational attainment equivalent to high school…

  13. Nonlinear electronic excitations in crystalline solids using meta-generalized gradient approximation and hybrid functional in time-dependent density functional theory

    SciTech Connect

    Sato, Shunsuke A.; Taniguchi, Yasutaka; Shinohara, Yasushi; Yabana, Kazuhiro

    2015-12-14

    We develop methods to calculate electron dynamics in crystalline solids in real-time time-dependent density functional theory employing exchange-correlation potentials which reproduce band gap energies of dielectrics; a meta-generalized gradient approximation was proposed by Tran and Blaha [Phys. Rev. Lett. 102, 226401 (2009)] (TBm-BJ) and a hybrid functional was proposed by Heyd, Scuseria, and Ernzerhof [J. Chem. Phys. 118, 8207 (2003)] (HSE). In time evolution calculations employing the TB-mBJ potential, we have found it necessary to adopt the predictor-corrector step for a stable time evolution. We have developed a method to evaluate electronic excitation energy without referring to the energy functional which is unknown for the TB-mBJ potential. For the HSE functional, we have developed a method for the operation of the Fock-like term in Fourier space to facilitate efficient use of massive parallel computers equipped with graphic processing units. We compare electronic excitations in silicon and germanium induced by femtosecond laser pulses using the TB-mBJ, HSE, and a simple local density approximation (LDA). At low laser intensities, electronic excitations are found to be sensitive to the band gap energy: they are close to each other using TB-mBJ and HSE and are much smaller in LDA. At high laser intensities close to the damage threshold, electronic excitation energies do not differ much among the three cases.

  14. Acyclovir resistant acute herpes simplex encephalitis associated with acute retinal necrosis: A case report and review of the literature.

    PubMed

    Ogura, Haruchika; Fukae, Jiro; Kimura, Satoshi; Aoki, Mikiko; Nabeshima, Kazuki; Tsuboi, Yoshio

    2017-05-27

    A 55-year-old man was admitted to our hospital for investigation of high fever, decreased consciousness and bilateral visual impairment. His cerebrospinal fluid analysis revealed pleocytosis of mononuclear cells and an increased protein concentration. FLAIR images revealed multiple high-intensity lesions in the frontal lobe, part of which was enhanced with gadolinium. Despite initiating treatment with acyclovir and corticosteroids, his consciousness and visual acuity deteriorated. Immunopathological examination of brain biopsies showed numerous herpes simplex virus type 2-positive neurons and macrophages, leading to a diagnosis of herpes simplex encephalitis (HSE). Fundoscopic examination revealed multiple foci of retinitis with vasculopathies, and inflammation in the anterior chamber and vitreous, indicating acute retinal necrosis (ARN). Foscarnet treatment was initiated in place of acyclovir and his consciousness improved, with a slight improvement in visual acuity. ARN is typically caused by a herpes virus infection limited to the eyeball, and rarely in combination with HSE. In such cases, there is a latency of approximately 2-4 weeks between ARN and the onset of encephalitis. Our case is unique in that HSE and ARN developed simultaneously, and it highlights that there may not always be a latency between the onsets of the two disorders. Finally, foscarnet should be considered in cases of HSE and ARN with acyclovir resistance.

  15. Differential recognition of heat shock elements by members of the heat shock transcription factor family.

    PubMed

    Yamamoto, Noritaka; Takemori, Yukiko; Sakurai, Mayumi; Sugiyama, Kazuhisa; Sakurai, Hiroshi

    2009-04-01

    Heat shock transcription factor (HSF), an evolutionarily conserved stress response regulator, forms trimers and binds to heat shock element (HSE), comprising at least three continuous inverted repeats of the sequence 5'-nGAAn-3'. The single HSF of yeast is also able to bind discontinuously arranged nGAAn units. We investigated interactions between three human HSFs and various HSE types in vitro, in yeast cells, and in HeLa cells. Human HSF1, a stress-activated regulator, preferentially bound to continuous HSEs rather than discontinuous HSEs, and heat shock of HeLa cells caused expression of reporter genes containing continuous HSEs. HSF2, whose function is implicated in neuronal specification and spermatogenesis, exhibited a slightly higher binding affinity to discontinuous HSEs than did HSF1. HSF4, a protein required for ocular lens development, efficiently recognized discontinuous HSEs in a trimerization-dependent manner. Among four human gamma-crystallin genes encoding structural proteins of the lens, heat-induced HSF1 preferred HSEs on the gammaA-crystallin and gammaB-crystallin promoters, whereas HSF4 preferred HSE on the gammaC-crystallin promoter. These results suggest that the HSE architecture is an important determinant of which HSF members regulate genes in diverse cellular processes.

  16. Psychosocial Hazards in UK Universities: Adopting a Risk Assessment Approach

    ERIC Educational Resources Information Center

    Kinman, Gail; Court, Stephen

    2010-01-01

    Drawing on the findings of a recent national survey, this article examines the extent to which higher education institutions in the United Kingdom meet the minimum standards recommended by the Health and Safety Executive (HSE) for the management of work-related stressors. A comparison is also made between the average weekly working hours reported…

  17. Academic Professionalism in the Era of Change: Role Subidentities and Transformation of Time Budgets

    ERIC Educational Resources Information Center

    Abramov, Roman Nikolaevich; Gruzdev, Ivan Andreevich; Terentyev, Evgeny Andreevich

    2016-01-01

    This article is based on a case study conducted within the National Research University Higher School of Economics (NRU HSE) that examined the identity fragmentation of academic professionals in the context of current educational and academic reforms in Russia. Seven hundred and five professors were surveyed for the study, which focused on…

  18. Polyphenolic extract from Hibiscus sabdariffa reduces body fat by inhibiting hepatic lipogenesis and preadipocyte adipogenesis.

    PubMed

    Kao, Erl-Shyh; Yang, Mon-Yuan; Hung, Chia-Hung; Huang, Chien-Ning; Wang, Chau-Jong

    2016-01-01

    Diets high in fat lead to excess lipid accumulation in adipose tissue, which is a crucial factor in the development of obesity, hepatitis, and hyperlipidemia. In this study, we investigated the anti-obesity effect of Hibiscus sabdariffa extract (HSE) in vivo. Hamsters fed a high-fat diet (HFD) develop symptoms of obesity, which were determined based on body weight changes and changes in plasma and serum triglycerides, free fatty acid concentrations, total cholesterol levels, LDL-C levels, HDL-C levels, and adipocyte tissue weight. HFD-fed hamsters were used to investigate the effects of HSE on symptoms of obesity such as adipogenesis and fatty liver, loss of blood glucose regulation, and serum ion imbalance. Interestingly, HSE treatment effectively reduced the effects of the HFD in hamsters in a dose-dependent manner. Further, after inducing maturation of preadipocytes, Hibiscus sabdariffa polyphenolic extract (HPE) was shown to suppress the adipogenesis of adipocytes. However, HPE does not affect the viability of preadipocytes. Therefore, both HSE and HPE are effective and viable treatment strategies for preventing the development and treating the symptoms of obesity.

  19. Cardiac and Vascular Synergic Protective Effect of Olea europea L. Leaves and Hibiscus sabdariffa L. Flower Extracts

    PubMed Central

    Micucci, Matteo; Gallina Toschi, Tullia; Di Lecce, Giuseppe; Aldini, Rita; Angeletti, Andrea; Chiarini, Alberto

    2015-01-01

    This study was aimed at investigating the cardiovascular effects of an Olea europea L. leaf extract (OEE), of a Hibiscus sabdariffa L. flower extract (HSE), and of their 13 : 2 w/w mixture in order to assess their cardiac and vascular activity. Both extracts were fully characterized in their bioactive compounds by HPLC-MS/MS analysis. The study was performed using primary vascular endothelial cells (HUVECs) to investigate the antioxidant and cytoprotective effect of the extracts and their mixture and isolated guinea-pig left and right atria and aorta to evaluate the inotropic and chronotropic activities and vasorelaxant properties. In cultured HUVECs, OEE and HSE reduced intracellular reactive oxygen species formation and improved cell viability, following oxidative stress in dose-dependent manner. OEE and HSE exerted negative inotropic and vasorelaxant effects without any chronotropic property. Interestingly, the mixture exerted higher cytoprotective effects and antioxidant activities. Moreover, the mixture exerted an inotropic effect similar to each single extract, while it revealed an intrinsic negative chronotropic activity different from the single extract; its relaxant activity was higher than that of each single extract. In conclusion OEE and HSE mixture has a good potential for pharmaceutical and nutraceutical application, thanks to the synergistic effects of the single phytochemicals. PMID:26180582

  20. Cardiac and Vascular Synergic Protective Effect of Olea europea L. Leaves and Hibiscus sabdariffa L. Flower Extracts.

    PubMed

    Micucci, Matteo; Malaguti, Marco; Toschi, Tullia Gallina; Di Lecce, Giuseppe; Aldini, Rita; Angeletti, Andrea; Chiarini, Alberto; Budriesi, Roberta; Hrelia, Silvana

    2015-01-01

    This study was aimed at investigating the cardiovascular effects of an Olea europea L. leaf extract (OEE), of a Hibiscus sabdariffa L. flower extract (HSE), and of their 13 : 2 w/w mixture in order to assess their cardiac and vascular activity. Both extracts were fully characterized in their bioactive compounds by HPLC-MS/MS analysis. The study was performed using primary vascular endothelial cells (HUVECs) to investigate the antioxidant and cytoprotective effect of the extracts and their mixture and isolated guinea-pig left and right atria and aorta to evaluate the inotropic and chronotropic activities and vasorelaxant properties. In cultured HUVECs, OEE and HSE reduced intracellular reactive oxygen species formation and improved cell viability, following oxidative stress in dose-dependent manner. OEE and HSE exerted negative inotropic and vasorelaxant effects without any chronotropic property. Interestingly, the mixture exerted higher cytoprotective effects and antioxidant activities. Moreover, the mixture exerted an inotropic effect similar to each single extract, while it revealed an intrinsic negative chronotropic activity different from the single extract; its relaxant activity was higher than that of each single extract. In conclusion OEE and HSE mixture has a good potential for pharmaceutical and nutraceutical application, thanks to the synergistic effects of the single phytochemicals.

  1. Ab Initio Modeling of Transition-Metal Impurities in MgO

    NASA Astrophysics Data System (ADS)

    Levchenko, Sergey V.; Alarcon Villaseca, Sebastian; Mazheika, Aliaksei; Scheffler, Matthias

    Fe- and Ni-doped MgO are promising materials for the catalytic conversion of methane and CO2. However, theoretical studies of these materials are scarce. The self-interaction error (SIE) in approximate DFT leads to an incorrect description of the electron localization and hybridization between d states of Ni or Fe and the oxide electronic bands. Replacing a fraction α of the (semi-)local exchange by the exact exchange reduces the SIE, but α remains a parameter depending on the target property. We explore the dependence of the formation energies of NiMg and FeMg substitutional defects in MgO on α in the Heyd-Scuseria-Ernzerhof hybrid functional (HSE), and compare the results to CCSD(T) embedded-cluster calculations. For NiMg defects HSE(α = 0.3) reproduces CCSD(T) formation energies and CO adsorption energies on NiMg. However, α = 0.48 is needed in the case of FeMg. For both NiMg and FeMg, α = 0.44-0.50 satisifies best the exact DFT condition that the HOMO does not depend on occupation. Contrary to PBE and HSE06, HSE(α ~ 0.5) reproduces the experimentally observed Oh -->D4 h (oblate) Jahn-Teller distortion for FeMg. We thank CoE UniCat for financial support.

  2. Human Systems Engineering: A Learning Model Designed To Converge Education, Business, and Industry.

    ERIC Educational Resources Information Center

    Hanson, Karen L.

    The Human Systems Engineering (HSE) Model was created to facilitate collaboration among education, business, and industry. It emphasized the role of leaders who converge with others to accomplish their goals while paying attention to the key elements that create successful partnerships. The partnership of XXsys Technologies, Inc., University of…

  3. Highly siderophile element and 182W evidence for a partial late veneer in the source of 3.8 Ga rocks from Isua, Greenland

    NASA Astrophysics Data System (ADS)

    Dale, Christopher W.; Kruijer, Thomas S.; Burton, Kevin W.

    2017-01-01

    The higher-than-expected concentrations of highly siderophile elements (HSE) in Earth's mantle most likely indicate that Earth received a small amount of late accreted mass after core formation had ceased, known as the 'late veneer'. Small 182W excesses in the Moon and in some Archaean rocks - such as the source of 3.8 billion-year-old Isua magmatics - also appear consistent with the late veneer hypothesis, with a lower proportion received. However, 182W anomalies can also relate to other processes, including early mantle differentiation. To better assess the origin of these W isotope anomalies - and specifically whether they relate to the late veneer - we have determined the HSE abundances and 182W compositions of a suite of mafic to ultramafic rocks from Isua, from which we estimate HSE abundances in the source mantle and ultimately constrain the 182W composition of the pre-late veneer mantle. Our data suggest that the Isua source mantle had HSE abundances at around 50-65% of the present-day mantle, consistent with partial, but not complete, isolation from the late veneer. These data also indicate that at least part of the late veneer had been added and mixed into the mantle at the time the Isua source formed, prior to 3.8 Ga. For the same Isua samples we obtained a 13 ± 4 ppm182W excess, compared to the modern terrestrial mantle, in excellent agreement with previous data. Using combined 182W and HSE data we show that the Moon, Isua, and the present-day bulk silicate Earth (BSE) produce a well-defined co-variation between 182W composition and the mass fraction of late-accreted mass, as inferred from HSE abundances. This co-variation is consistent with the calculated effects of various late accretion compositions on the HSE and 182W signatures of Earth's mantle. The empirical relationship, therefore, implies that the Moon, Isua source and BSE received increasing proportions of late-accreted mass, supporting the idea of disproportional late accretion to the Earth

  4. 187Re-187Os systematics, highly siderophile element, S-Se-Te abundances in the components of unequilibrated L chondrites

    NASA Astrophysics Data System (ADS)

    Kadlag, Yogita; Becker, Harry

    2016-01-01

    The 187Re-187Os systematics, abundances of highly siderophile elements (HSE: Re, platinum group elements and Au), Te, Se and S as well as major and minor elements were determined in separated components of two unequilibrated L chondrites QUE 97008 (L3.05) and Ceniceros (L3.7). The 187Re-187Os systematics are disturbed in the components of both meteorites, most likely due to open system behavior of Re during terrestrial weathering of QUE 97008 and alteration on the L chondrite parent body as indicated by an internal errorchron generated for components of Ceniceros. The HSE abundance patterns suggest that the bulk rock abundances were mainly controlled by two different end members. Non-magnetic fractions display lower Re/Os and HSE/Ir than CI chondrites. Chondrules, metal-troilite spherules and fine magnetic fractions, are depleted in refractory HSE and show higher Rh/Ir, Pd/Ir and Au/Ir than in CI chondrites. The different HSE compositions indicate the presence of unequilibrated alloys and loss of refractory HSE-rich carrier phases from the precursors of some L chondrite components. Gold is decoupled from other HSE in magnetic fractions and shows chalcophile affinities with a grain size dependent variation similar to S and Se, presumably inherited from preaccretionary processes. Tellurium is depleted in all components compared to other analysed siderophile elements, and its abundance was most likely controlled by fractional condensation and different geochemical affinities. The volatility dependent depletion of Te requires different physical and chemical conditions than typical for the canonical condensation sequence as represented by carbonaceous chondrites. Tellurium also shows variable geochemical behavior, siderophile in Ceniceros, predominantly chalcophile in QUE 97008. These differences may have been inherited from element partitioning during chondrule formation. Selenium and S on the other hand are almost unfractionated from each other and only show

  5. Geochemistry of impact glasses and target rocks from the Zhamanshin impact structure, Kazakhstan: Implications for mixing of target and impactor matter

    NASA Astrophysics Data System (ADS)

    Jonášová, Šárka; Ackerman, Lukáš; Žák, Karel; Skála, Roman; Ďurišová, Jana; Deutsch, Alexander; Magna, Tomáš

    2016-10-01

    Internal structure and element chemistry including contents of highly siderophile elements (HSE) and Os isotope ratios have been studied in target rocks and several groups of impact glasses of the Zhamanshin impact structure, Kazakhstan. These include larger irregularly-shaped fragments and blocks of impact glass (zhamanshinites), and three types of tektite-like splash-form glasses, part of fallback ejecta. These glassy objects typically are up to 30 mm large and are shaped as teardrops, irregularly bent and curved glass rods and fibers. They can be subdivided into acidic types (irghizites; typically 69-76 wt.% SiO2), basic splash-forms (typically 53-56 wt.% SiO2), and rarely occurring highly inhomogeneous composites with abundant mineral inclusions. A comparison with the target rocks shows that zhamanshinites and basic splash-forms usually have no detectable admixture of the projectile matter, indicated by major and trace elements as well as highly siderophile element contents, with the exception of one sample containing Fe-, Cr-, Ni- and Ti-enriched particles and elevated HSE contents. In contrast, irghizites exhibit clear admixture of the projectile matter, which was incorporated by complex processes accompanied by strong element fractionations. Microscopic investigations confirm that irghizites were formed mainly by coalescence of smaller molten glass droplets sized typically below 1 mm. Irghizites exhibit significant enrichments in Ni, Co and Cr, whose concentrations are locally elevated in the rims of the original small droplets. A portion of these elements and also part of Fe and Mn and other elements were derived from the impactor, most likely a Ni-rich carbonaceous chondrite. The contents of HSE are low and strongly fractionated, with moderate depletions of Pt and Pd and strong depletions of other HSE with respect to chondritic element ratios. Osmium shows the strongest depletion, likely related to the presence of oxygen in the post-impact atmosphere

  6. Characterization of the dominant impactor signature for Apollo 17 impact melt rocks

    NASA Astrophysics Data System (ADS)

    Sharp, Miriam; Gerasimenko, Iva; Loudin, Lorne C.; Liu, Jingao; James, Odette B.; Puchtel, Igor S.; Walker, Richard J.

    2014-04-01

    Concentrations of the highly siderophile elements (HSE) Re, Os, Ir, Ru, Pt, and Pd and 187Os/188Os isotopic compositions are reported for seven Apollo 17 impact melt rocks. These data are used to examine the dominant chemical signature of the impactor that formed the melts. Six of the samples (72355, 72435, 72535, 76035, 76055, and 76135) have poikilitic textures; one sample (73235) has an aphanitic texture. Data for the samples define linear correlations when Ir is plotted versus other HSE concentrations, with y-intercepts indistinguishable from zero for most HSE in most rocks. Scatter about some of the trends, and occasional trends with positive y-intercepts, indicate either mixing of additional components that are heterogeneously distributed within several rocks, or modest fractionation of some HSE by volatilization, crystal fractionation, or other processes, during formation and evolution of the melt sheet. There is no statistical difference between the aphanitic and poikilitic samples in terms of HSE ratios after visible granulitic clasts were removed from aphanite 73235. Hence, earlier speculations that the two types of impact melt rocks at this site may have been generated by different impactors are not supported by our data. Most Apollo 17 samples examined here and in prior studies are characterized by very similar HSE signatures, consistent with a common impactor. These samples are characterized by elevated Ru/Ir, Pd/Ir, and Re/Os, relative to most chondrites. Collectively, the data indicate that the impactor was characterized by the following HSE ratios (2σ): Re/Ir 0.093 ± 0.020, Os/Ir 1.03 ± 0.28, Ru/Ir 1.87 ± 0.30, Pt/Ir 2.36 ± 0.31, Pd/Ir 1.85 ± 0.41, and present-day 187Os/188Os of 0.1322 ± 0.0013. The results most likely mean that the impactor was a body with a bulk composition that was just outside the range of meteoritic compositions currently sampled on Earth.

  7. Targeting the (3.8-4.0 Ga) Impactors: Siderophile Element Signatures of Lunar Impact Melts

    NASA Astrophysics Data System (ADS)

    Bennett, V.; Norman, M.; Ryder, G.

    2001-12-01

    Significant gaps remain in our understanding of the early impact history of the Earth and Moon, and their influence on geologic and biologic development. Outstanding controversies include whether or not the Moon, and by inference the early Earth, was hit by an unusually heavy "terminal cataclysm" of collisions during the period 3.8 to 4.0 Ga, and the number of large impact events represented by lunar samples. Coincidentally or not, the large nearside lunar basins are almost identical in age with the oldest terrestrial rocks, and are therefore relevant for consideration of the possible role of impacts in shaping the terrestrial continents and early life environments. To improve our understanding of the impact history of the Moon and to provide new information about the types of planetesimals that were involved in the early impact history of the inner Solar System, we measured the concentrations of highly siderophile elements (HSE: Re, Ir, Pt, Pd, Ru) in a suite of Apollo 17 impact melt breccias using high precision ID-ICPMS methods. These breccias all have poikilitic textures, relatively mafic bulk compositions, and high levels of incompatible trace elements and all likely represent ejecta from the Serenitatis basin. Ar-Ar ages are consistent with the formation of these breccias in a single impact event at 3893 +/- 9 Ma. HSE from 11 representative samples have W-shaped patterns on CI-normalized diagrams, with enrichments in Re, Ru and Pd relative to Ir and Pt, and absolute abundances ranging from \\sim0.5 to 4% of CI reference values. Stronger depletions of Ir and Pt relative to Re, Ru, and Pd are correlated with decreasing HSE concentrations. The samples with the highest HSE concentrations have patterns that are identical to those of EH chondrites, but the patterns become increasingly less diagnostic of meteorite group with decreasing concentrations. The systematic variation of HSE patterns with decreasing concentration suggests that simple chemical fingerprints of

  8. Late Chondritic Additions and Planet and Planetesimal Growth: Evaluation of Physical and Chemical Mechanisms

    NASA Technical Reports Server (NTRS)

    Righter, Kevin

    2013-01-01

    Studies of terrestrial peridotite and martian and achondritic meteorites have led to the conclusion that addition of chondritic material to growing planets or planetesimals, after core formation, occurred on Earth, Mars, asteroid 4 Vesta, and the parent body of the angritic meteorites [1-4]. One study even proposed that this was a common process in the final stages of growth [5]. These conclusions are based almost entirely on the highly siderophile elements (HSE; Re, Au, Pt, Pd, Rh, Ru, Ir, Os). The HSE are a group of eight elements that have been used to argue for late accretion of chondritic material to the Earth after core formation was complete (e.g., [6]). This idea was originally proposed because the D(metal/silicate) values for the HSE are so high, yet their concentration in the mantle is too high to be consistent with such high Ds. The HSE also are present in chondritic relative abundances and hence require similar Ds if this is the result of core-mantle equilibration. Since the work of [6] there has been a realization that core formation at high PT conditions can explain the abundances of many siderophile elements in the mantle (e.g., [7]), but such detailed high PT partitioning data are lacking for many of the HSE to evaluate whether such ideas are viable for all four bodies. Consideration of other chemical parameters reveals larger problems that are difficult to overcome, but must be addressed in any scenario which calls on the addition of chondritic material to a reduced mantle. Yet these problems are rarely discussed or emphasized, making the late chondritic (or late veneer) addition hypothesis suspect.

  9. Arabidopsis HEAT SHOCK TRANSCRIPTION FACTORA1b overexpression enhances water productivity, resistance to drought, and infection

    PubMed Central

    Richard, François; Bowden, Laura; Morison, James I.L.; Mullineaux, Philip M.

    2013-01-01

    Heat-stressed crops suffer dehydration, depressed growth, and a consequent decline in water productivity, which is the yield of harvestable product as a function of lifetime water consumption and is a trait associated with plant growth and development. Heat shock transcription factor (HSF) genes have been implicated not only in thermotolerance but also in plant growth and development, and therefore could influence water productivity. Here it is demonstrated that Arabidopsis thaliana plants with increased HSFA1b expression showed increased water productivity and harvest index under water-replete and water-limiting conditions. In non-stressed HSFA1b-overexpressing (HSFA1bOx) plants, 509 genes showed altered expression, and these genes were not over-represented for development-associated genes but were for response to biotic stress. This confirmed an additional role for HSFA1b in maintaining basal disease resistance, which was stress hormone independent but involved H2O2 signalling. Fifty-five of the 509 genes harbour a variant of the heat shock element (HSE) in their promoters, here named HSE1b. Chromatin immunoprecipitation-PCR confirmed binding of HSFA1b to HSE1b in vivo, including in seven transcription factor genes. One of these is MULTIPROTEIN BRIDGING FACTOR1c (MBF1c). Plants overexpressing MBF1c showed enhanced basal resistance but not water productivity, thus partially phenocopying HSFA1bOx plants. A comparison of genes responsive to HSFA1b and MBF1c overexpression revealed a common group, none of which harbours a HSE1b motif. From this example, it is suggested that HSFA1b directly regulates 55 HSE1b-containing genes, which control the remaining 454 genes, collectively accounting for the stress defence and developmental phenotypes of HSFA1bOx. PMID:23828547

  10. Pumpless microfluidic platform for drug testing on human skin equivalents

    PubMed Central

    Abaci, Hasan Erbil; Gledhill, Karl; Guo, Zongyou; Christiano, Angela M.; Shuler, Michael L.

    2014-01-01

    Advances in bio-mimetic in vitro human skin models increase the efficiency of drug screening studies. In this study, we designed and developed a microfluidic platform that allows for long-term maintenance of full thickness human skin equivalents (HSE) which are comprised of both the epidermal and dermal compartments. The design is based on the physiologically relevant blood residence times in human skin tissue and allows for the establishment of an air-epidermal interface which is crucial for maturation and terminal differentiation of HSEs. The small scale of the design reduces the amount of culture medium and the number of cells required by 36 fold compared to conventional transwell cultures. Our HSE-on-a-chip platform has the capability to recirculate the medium at desired flow rates without the need for pump or external tube connections. We demonstrate that the platform can be used to maintain HSEs for three weeks with proliferating keratinocytes similar to conventional HSE cultures. Immunohistochemistry analyses show that the differentiation and localization of keratinocytes was successfully achieved, establishing all sub-layers of the epidermis after one week. Basal keratinocytes located at the epidermal-dermal interface remain in a proliferative state for three weeks. We use a transdermal transport model to show that the skin barrier function is maintained for three weeks. We also validate the capability of the HSE-on-a-chip platform to be used for drug testing purposes by examining the toxic effects of doxorubucin on skin cells and structure. Overall, the HSE-on-a-chip is a user-friendly and cost-effective in vitro platform for drug testing of candidate molecules for skin disorders. PMID:25490891

  11. Pumpless microfluidic platform for drug testing on human skin equivalents.

    PubMed

    Abaci, Hasan Erbil; Gledhill, Karl; Guo, Zongyou; Christiano, Angela M; Shuler, Michael L

    2015-02-07

    Advances in bio-mimetic in vitro human skin models increase the efficiency of drug screening studies. In this study, we designed and developed a microfluidic platform that allows for long-term maintenance of full thickness human skin equivalents (HSE) which are comprised of both the epidermal and dermal compartments. The design is based on the physiologically relevant blood residence times in human skin tissue and allows for the establishment of an air-epidermal interface which is crucial for maturation and terminal differentiation of HSEs. The small scale of the design reduces the amount of culture medium and the number of cells required by 36 fold compared to conventional transwell cultures. Our HSE-on-a-chip platform has the capability to recirculate the medium at desired flow rates without the need for pump or external tube connections. We demonstrate that the platform can be used to maintain HSEs for three weeks with proliferating keratinocytes similar to conventional HSE cultures. Immunohistochemistry analyses show that the differentiation and localization of keratinocytes was successfully achieved, establishing all sub-layers of the epidermis after one week. Basal keratinocytes located at the epidermal-dermal interface remain in a proliferative state for three weeks. We use a transdermal transport model to show that the skin barrier function is maintained for three weeks. We also validate the capability of the HSE-on-a-chip platform to be used for drug testing purposes by examining the toxic effects of doxorubucin on skin cells and structure. Overall, the HSE-on-a-chip is a user-friendly and cost-effective in vitro platform for drug testing of candidate molecules for skin disorders.

  12. Hybrid functional calculation of electronic and phonon structure of BaSnO{sub 3}

    SciTech Connect

    Kim, Bog G.; Jo, J.Y.; Cheong, S.W.

    2013-01-15

    Barium stannate, BaSnO{sub 3} (BSO), with a cubic perovskite structure, has been highlighted as a promising host material for the next generation transparent oxide electrodes. This study examined theoretically the electronic structure and phonon structure of BSO using hybrid density functional theory based on the HSE06 functional. The electronic structure results of BSO were corrected by extending the phonon calculations based on the hybrid density functional. The fundamental thermal properties were also predicted based on a hybrid functional calculation. Overall, a detailed understanding of the electronic structure, phonon modes and phonon dispersion of BSO will provide a theoretical starting-point for engineering applications of this material. - Graphical Abstract: (a) Crystal structure of BaSnO{sub 3}. The center ball is Ba and small (red) ball on edge is oxygen and SnO{sub 6} octahedrons are plotted as polyhedron. (b) Electronic band structure along the high symmetry point in the Brillouin zone using the HSE06 hybrid functional. (c) The phonon dispersion curve calculated using the HSE06 hybrid functional (d) Zone center lowest energy F{sub 1u} phonon mode. Highlights: Black-Right-Pointing-Pointer We report the full hybrid functional calculation of not only the electronic structure but also the phonon structure for BaSnO{sub 3}. Black-Right-Pointing-Pointer The band gap calculation of HSE06 revealed an indirect gap with 2.48 eV. Black-Right-Pointing-Pointer The effective mass at the conduction band minimum and valence band maximum was calculated. Black-Right-Pointing-Pointer In addition, the phonon structure of BSO was calculated using the HSE06 functional. Black-Right-Pointing-Pointer Finally, the heat capacity was calculated and compared with the recent experimental result.

  13. Perceived health-related self-efficacy associated with BMI in adults in a population-based survey.

    PubMed

    Ovaskainen, Marja-Leena; Tapanainen, Heli; Laatikainen, Tiina; Männistö, Satu; Heinonen, Heikki; Vartiainen, Erkki

    2015-03-01

    The concept of ability to control personal behaviour in various environmental temptations is called self-efficacy. The high prevalence of obesity and overweight in Finland is the reason for studying the determinants of weight. The aim of the present study was to clarify the associations between body mass index and health-related self-efficacy (HSE), including food patterns, health behaviour and education. A random sample of adults was invited to the cross-sectional FINRISK 2002 Study in six regions in Finland. Participants (n=7784) gave information on education, health behaviour, HSE and food consumption. Height and weight were measured in a health examination. The response rate was 60% for men and 71% for women. Six food patterns were identified by principal component analysis on the basis of food consumption. The scores from seven-item HSE was calculated and categorized into tertiles for the analysis. The associations of BMI with self-efficacy and exploratory variables were tested using general linear modelling in total population and by gender. A weak HSE was associated with a higher BMI after adjusting for age, education, food patterns and health behaviour. In addition, low education, infrequent PA and non-smoking were associated with the higher BMI, but the association of HSE and BMI remained in multivariate model. The associations of food patterns and BMI were small. The adverse association with BMI was observed for patterns with sweet and butter. The study supports the importance of self-control in weight management, which needs to be considered as an empowerment tool in health education. © 2015 the Nordic Societies of Public Health.

  14. Effects of changing reference values and definition of the normal range on interpretation of spirometry.

    PubMed

    Brazzale, Danny J; Upward, Allyson L; Pretto, Jeffrey J

    2010-10-01

    Recent spirometry reference studies are arguably the most valid ever performed and the ATS/ERS now recommend the National Health and Nutrition Assessment Survey (NHANES) equations for North America. It is timely to consider adopting these reference values in Australasia; however, an evaluation of the consequences of such a change is required. We analysed data from 1108 patients tested in two pulmonary function laboratories in public hospitals. Lower limits of normal (LLN) were calculated using European Community for Steel and Coal (ECSC) (1993), Knudson (1983), NHANES (1999) and Health Survey of England (HSE) (2004) equations and used to define restriction (FVC < LLN) and obstruction (FEV(1)/FVC < LLN). This interpretative strategy was also compared with the GOLD definition of obstruction (FEV(1)/FVC < 70%). Average age for all patients (50% female) was 60 years (range: 20-91). The mean predicted FVC from NHANES and HSE were similar and consistently higher than those from ECSC and Knudson (average 270 mLs). This translates into a 76% increase in the incidence of 'restrictive' interpretations using NHANES data compared with ECSC and Knudson, and a smaller increase of 40% for HSE. Using FEV(1)/FVC < 70% to diagnose obstruction in those over 65 years would result in false positive rates of approximately 28%. Using the same definition in a younger group (<50 years old) results in a false negative rate of approximately 14%. Changing to either NHANES or HSE predicted values will significantly increase the rate of 'restrictive' interpretation, and alter the rate of obstructive findings. The NHANES and HSE data confirm that using FEV(1)/FVC < 70% to define obstruction causes misdiagnosis in elderly and younger subjects. © 2010 The Authors; Respirology © 2010 Asian Pacific Society of Respirology.

  15. Autoimmune post-herpes simplex encephalitis of adults and teenagers.

    PubMed

    Armangue, Thaís; Moris, Germán; Cantarín-Extremera, Verónica; Conde, Carlos Enrique; Rostasy, Kevin; Erro, Maria Elena; Portilla-Cuenca, Juan Carlos; Turón-Viñas, Eulàlia; Málaga, Ignacio; Muñoz-Cabello, Beatriz; Torres-Torres, Carmen; Llufriu, Sara; González-Gutiérrez-Solana, Luis; González, Guillermo; Casado-Naranjo, Ignacio; Rosenfeld, Myrna; Graus, Francesc; Dalmau, Josep

    2015-11-17

    To report 14 patients with immune-mediated relapsing symptoms post-herpes simplex encephalitis (HSE) and to compare the clinical and immunologic features of the teenage and adult group with those of young children. Prospective observational study of patients diagnosed between June 2013 and February 2015. Immunologic techniques have been reported previously. Among the teenage and adult group (8 patients, median age 40 years, range 13-69; 5 male), 3 had an acute symptom presentation suggesting a viral relapse, and 5 a presentation contiguous with HSE suggesting a recrudescence of previous deficits. Seven patients developed severe psychiatric/behavioral symptoms disrupting all social interactions, and one refractory status epilepticus. Blepharospasm occurred in one patient. Five patients had CSF antibodies against NMDA receptor (NMDAR) and 3 against unknown neuronal cell surface proteins. In 5/6 patients, the brain MRI showed new areas of contrast enhancement that decreased after immunotherapy and clinical improvement. Immunotherapy was useful in 7/7 patients, sometimes with impressive recoveries, returning to their baseline HSE residual deficits. Compared with the 6 younger children (median age 13 months, range 6-20, all with NMDAR antibodies), the teenagers and adults were less likely to develop choreoathetosis (0/8 vs 6/6, p < 0.01) and decreased level of consciousness (2/8 vs 6/6, p < 0.01) and had longer delays in diagnosis and treatment (interval relapse/antibody testing 85 days, range 17-296, vs 4 days, range 0-33, p = 0.037). In teenagers and adults, the immune-mediated relapsing syndrome post-HSE is different from that known in young children as choreoathetosis post-HSE and is underrecognized. Prompt diagnosis is important because immunotherapy can be highly effective. © 2015 American Academy of Neurology.

  16. Herpes Simplex Encephalitis: Lack of Clinical Benefit of Long-term Valacyclovir Therapy.

    PubMed

    Gnann, John W; Sköldenberg, Birgit; Hart, John; Aurelius, Elisabeth; Schliamser, Silvia; Studahl, Marie; Eriksson, Britt-Marie; Hanley, Daniel; Aoki, Fred; Jackson, Alan C; Griffiths, Paul; Miedzinski, Lil; Hanfelt-Goade, Diane; Hinthorn, Daniel; Ahlm, Clas; Aksamit, Allen; Cruz-Flores, Salvador; Dale, Ilet; Cloud, Gretchen; Jester, Penelope; Whitley, Richard J

    2015-09-01

    Despite the proven efficacy of acyclovir (ACV) therapy, herpes simplex encephalitis (HSE) continues to cause substantial morbidity and mortality. Among patients with HSE treated with ACV, the mortality rate is approximately 14%-19%. Among survivors, 45%-60% have neuropsychological sequelae at 1 year. Thus, improving therapeutic approaches to HSE remains a high priority. Following completion of a standard course of intravenous ACV, 87 adult patients with HSE (confirmed by positive polymerase chain reaction [PCR] for herpes simplex virus DNA in cerebrospinal fluid) were randomized to receive either valacyclovir (VACV) 2 g thrice daily (n = 40) or placebo tablets (n = 47) for 90 days (12 tablets of study medication daily). The primary endpoint was survival with no or mild neuropsychological impairment at 12 months, as measured by the Mattis Dementia Rating Scale (MDRS). Logistic regression was utilized to assess factors related to the primary endpoint. The demographic characteristics of the 2 randomization groups were statistically similar with no significant differences in age, sex, or race. At 12 months, there was no significant difference in the MDRS scoring for VACV-treated vs placebo recipients, with 85.7% and 90.2%, respectively, of patients demonstrating no or mild neuropsychological impairment (P = .72). No significant study-related adverse events were encountered in either treatment group. Following standard treatment with intravenous ACV for PCR-confirmed HSE, an additional 3-month course of oral VACV therapy did not provide added benefit as measured by neuropsychological testing 12 months later in a population of relatively high-functioning survivors. NCT00031486. © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  17. Autoimmune post–herpes simplex encephalitis of adults and teenagers

    PubMed Central

    Armangue, Thaís; Moris, Germán; Cantarín-Extremera, Verónica; Conde, Carlos Enrique; Rostasy, Kevin; Erro, Maria Elena; Portilla-Cuenca, Juan Carlos; Turón-Viñas, Eulàlia; Málaga, Ignacio; Muñoz-Cabello, Beatriz; Torres-Torres, Carmen; Llufriu, Sara; González-Gutiérrez-Solana, Luis; González, Guillermo; Casado-Naranjo, Ignacio; Rosenfeld, Myrna; Graus, Francesc

    2015-01-01

    Objective: To report 14 patients with immune-mediated relapsing symptoms post–herpes simplex encephalitis (HSE) and to compare the clinical and immunologic features of the teenage and adult group with those of young children. Methods: Prospective observational study of patients diagnosed between June 2013 and February 2015. Immunologic techniques have been reported previously. Results: Among the teenage and adult group (8 patients, median age 40 years, range 13–69; 5 male), 3 had an acute symptom presentation suggesting a viral relapse, and 5 a presentation contiguous with HSE suggesting a recrudescence of previous deficits. Seven patients developed severe psychiatric/behavioral symptoms disrupting all social interactions, and one refractory status epilepticus. Blepharospasm occurred in one patient. Five patients had CSF antibodies against NMDA receptor (NMDAR) and 3 against unknown neuronal cell surface proteins. In 5/6 patients, the brain MRI showed new areas of contrast enhancement that decreased after immunotherapy and clinical improvement. Immunotherapy was useful in 7/7 patients, sometimes with impressive recoveries, returning to their baseline HSE residual deficits. Compared with the 6 younger children (median age 13 months, range 6–20, all with NMDAR antibodies), the teenagers and adults were less likely to develop choreoathetosis (0/8 vs 6/6, p < 0.01) and decreased level of consciousness (2/8 vs 6/6, p < 0.01) and had longer delays in diagnosis and treatment (interval relapse/antibody testing 85 days, range 17–296, vs 4 days, range 0–33, p = 0.037). Conclusion: In teenagers and adults, the immune-mediated relapsing syndrome post-HSE is different from that known in young children as choreoathetosis post-HSE and is underrecognized. Prompt diagnosis is important because immunotherapy can be highly effective. PMID:26491084

  18. Antibodies to a fragment of the Bothrops moojenil-amino acid oxidase cross-react with snake venom components unrelated to the parent protein.

    PubMed

    Stábeli, Rodrigo Guerino; Magalhães, Lívia Maria Pimenta; Selistre-de-Araujo, Heloísa S; Oliveira, Eduardo Brandt

    2005-09-01

    It is widely accepted that immunological cross-reactivity of snake venoms is mediated by antibodies that recognize venom components bearing either amino acid sequence homology or similar biological functions. However, here we demonstrate that polyspecific Bothrops antivenom is a source of cross-reactive antibodies that interact with venom proteins of distinctive primary structures and biological functions. The homoserine lactone derivative of the undecapeptide IQRWSLDKYAM (Ile1-Hse11), excised from the l-amino acid oxidase (LAAO) of the Bothrops moojeni venom, was the ligand of an affinity resin used to isolate specific anti-Ile1-Hse11 antibodies which were instrumental in revealing immunological cross-reactivity among unrelated venom proteins. We examined the extent of the cross-reactivity of these antibodies by probing electroblots of venoms from representative snakes of genera Bothrops, Lachesis, Crotalus and Micrurus, and by unambiguous structural characterization of the affinity-purified proteins of B. moojeni venom recovered from an agarose-anti-Ile1-Hse11 column. Our results indicate that all venoms tested had at least three reactive components toward anti-Ile1-Hse11 antibodies, among which we identified two serine proteases, one phospholipase A2 homologue, and LAAO. We hypothesize that the cross-reactivity of the anti-Ile1-Hse11 antibodies to unrelated venom proteins derives from their mechanism of antigen recognition, whereby complementarity is achieved through reciprocal conformational adaptation of the reacting molecules. Also, we believe these findings have implications both in the development of improved antivenoms and the preparation of immunochemical reagents for diagnostic and scientific investigation purposes in the field of snake venoms.

  19. Ketamine Inhibits ATP-Evoked Exocytotic Release of Brain-Derived Neurotrophic Factor from Vesicles in Cultured Rat Astrocytes.

    PubMed

    Stenovec, Matjaž; Lasič, Eva; Božić, Mićo; Bobnar, Saša Trkov; Stout, Randy F; Grubišić, Vladimir; Parpura, Vladimir; Zorec, Robert

    2016-12-01

    In the brain, astrocytes signal to neighboring cells via regulated exocytotic release of gliosignaling molecules, such as brain-derived neurotrophic factor (BDNF). Recent studies uncovered a role of ketamine, an anesthetic and antidepressant, in the regulation of BDNF expression and in the disruption of astrocytic Ca(2+) signaling, but it is unclear whether it affects astroglial BDNF release. We investigated whether ketamine affects ATP-evoked Ca(2+) signaling and exocytotic release of BDNF at the single-vesicle level in cultured rat astrocytes. Cells were transfected with a plasmid encoding preproBDNF tagged with the pH-sensitive fluorescent protein superecliptic pHluorin, (BDNF-pHse) to load vesicles and measure the release of BDNF-pHse when the exocytotic fusion pore opens and alkalinizes the luminal pH. In addition, cell-attached membrane capacitance changes were recorded to monitor unitary vesicle interaction with the plasma membrane. Intracellular Ca(2+) activity was monitored with Fluo-4 and confocal microscopy, which was also used to immunocytochemically characterize BDNF-pHse-laden vesicles. As revealed by double-fluorescent micrographs, BDNF-pHse localized to vesicles positive for the soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) proteins, vesicle-associated membrane protein 2 (VAMP2), VAMP3, and synaptotagmin IV. Ketamine treatment decreased the number of ATP-evoked BDNF-pHse fusion/secretion events (P < 0.05), the frequency of ATP-evoked transient (P < 0.001) and full-fusion exocytotic (P < 0.05) events, along with a reduction in the ATP-evoked increase in intracellular Ca(2+) activity in astrocytes by ~70 % (P < 0.001). The results show that ketamine treatment suppresses ATP-triggered vesicle fusion and BDNF secretion by increasing the probability of a narrow fusion pore open state and/or by reducing astrocytic Ca(2+) excitability.

  20. Neonatal hormone changes and growth in lambs born to dams receiving differing nutritional intakes and selenium supplementation during gestation.

    PubMed

    Camacho, Leticia E; Meyer, Allison M; Neville, Tammi L; Hammer, Carolyn J; Redmer, Dale A; Reynolds, Lawrence P; Caton, Joel S; Vonnahme, Kimberly A

    2012-07-01

    To investigate the effects of maternal selenium (Se) supplementation and nutritional intake during gestation on hormone changes, percentage body weight (BW) change, and organ mass in neonatal lambs, ewes were allocated to differing Se levels (adequate Se (ASe, 11.5 μg/kg BW) or high Se (HSe, 77.0 μg/kg BW)) initiated at breeding and nutritional intake (60% (RES), 100% (CON), or 140% (HIGH) of NRC requirements) initiated at day 40 of gestation. At parturition, all lambs were removed from dams, fed common diets, and BW and blood samples were collected until day 19. There was a Se × nutritional intake × day interaction for percentage BW change from birth. Lambs born to ASe-HIGH ewes tended to have decreased BW change compared with ASe-CON and ASe-RES groups on day 7. Lambs from HSe-HIGH ewes tended to have increased BW change compared with HSe-RES and HSe-CON groups from days 7 to 19. At birth, there was a Se × sex of offspring interaction, in which male lambs from HSe ewes had decreased cortisol concentrations compared with all other lambs. By 24 h, lambs from RES ewes had decreased cortisol compared with those from HIGH ewes, with lambs from CON ewes being intermediate. Lambs from RES- and CON-fed ewes had greater thyroxine than HIGH ewes at 24 h. Organ masses on day 19 were mainly impacted by maternal nutritional intake and sex of the offspring. Birth weight alone did not predict growth performance during neonatal life. Moreover, despite a similar postnatal diet, maternal nutritional plane and Se status did impact neonatal endocrine profiles. Exact mechanisms of how neonatal endocrine status can influence later growth and development need to be determined.

  1. The role of range-separated Hartree-Fock exchange in the calculation of magnetic exchange couplings in transition metal complexes.

    PubMed

    Phillips, Jordan J; Peralta, Juan E

    2011-01-21

    We assess the dependence of magnetic exchange couplings on the variation of Hartree-Fock exchange (HFX) admixture in global hybrid functionals and the range-separation parameter ω in range-separated hybrid functionals in a set of 12 spin-1/2 binuclear transition metal complexes. The global hybrid PBEh (hybrid Perdew-Burke-Ernzerhof) and range-separated hybrids HSE (Heyd-Scuseria-Ernzerhof) and LC-ωPBE (long-range corrected hybrid PBE) are employed for this assessment, and exchange couplings are calculated from energy differences within the framework of the spin-projected approach. It is found that these functionals perform optimally for magnetic exchange couplings with 35% HFX admixture for PBEh, ω = 0.50 a.u.(-1) for LC-ωPBE, and ω at or near 0.0 a.u.(-1) for HSE (which corresponds to PBEh). We find that in their standard respective forms, LC-ωPBE slightly outperforms PBEh, while PBEh with 35% HFX yields exchange couplings closer to experiment than those of LC-ωPBE with ω = 0.50 a.u.(-1). Additionally, we show that the profile of exchange couplings with respect to ω in HSE is appreciably flat from 0 to 0.2 a.u.(-1). This combined with the fact that HSE is computationally more tractable than global hybrids makes HSE an attractive alternative for the evaluation of exchange couplings in extended systems. These results are rationalized with respect to how varying the parameters within these functionals affects the delocalization of the magnetic orbitals, and conclusions are made regarding the relative importance of range separation versus global mixing of HFX for the calculation of exchange couplings.

  2. Social class-related gradient in the association of skeletal growth with blood pressure among adolescent boys in India.

    PubMed

    Rao, Shobha; Apte, Priti

    2009-12-01

    In view of the fact that height differences between socio-economic groups are apparent early in childhood, it is of interest to examine whether skeletal growth is reflective of the social class gradient in CVD risk. The present study examined blood pressure levels, adiposity and growth of adolescent boys from high and low social classes. In a cross-sectional study, skeletal growth (height and sitting height), adiposity (weight, BMI and body fat) and blood pressure levels of the adolescents were measured. Pune, India. Adolescent schoolboys (9-16 years) from high socio-economic (HSE; n 1146) and low socio-economic (LSE; n 932) class. LSE boys were thin, short and undernourished (mean BMI: 15.5 kg/m2 v. 19.3 kg/m2 in HSE boys, P = 0.00). Social gradient was revealed in differing health risks. The prevalence of high systolic blood pressure (HSBP) was high in HSE class (10.5 % v. 2.7 % in LSE class, P = 0.00) and was associated with adiposity, while the prevalence of high diastolic blood pressure (HDBP) was high in LSE class (9.8 % v. 7.0 % in HSE class, P = 0.00) and had only a weak association with adiposity. Despite this, lower ratio of leg length to height was associated with significantly higher respective health risks, i.e. for HDBP in LSE class (OR = 1.99, 95 % CI 1.14, 3.47) and for HSBP in HSE class (OR = 1.69, 95 % CI 1.02, 2.77). As stunting in childhood is a major problem in India and Asia, the leg length to height indicator needs to be validated in different populations to understand CVD risks.

  3. Metadata: Pure and Simple, or Is It?

    ERIC Educational Resources Information Center

    Chalmers, Marilyn

    2002-01-01

    Discusses issues concerning metadata in Web pages based on experiences in a vocational education center library in Queensland (Australia). Highlights include Dublin Core elements; search engines; controlled vocabulary; performance measurement to assess usage patterns and provide quality control over the vocabulary; and considerations given the…

  4. Case Study of a Project-Based Learning Course in Civil Engineering Design

    ERIC Educational Resources Information Center

    Gavin, K.

    2011-01-01

    This paper describes the use of project-based learning to teach design skills to civil engineering students at University College Dublin (UCD). The paper first considers the development of problem-based leaning (PBL) as a tool in higher education. The general issues to be considered in the design of the curriculum for a PBL module are reviewed.…

  5. Design of the Curriculum for a Second-Cycle Course in Civil Engineering in the Context of the Bologna Framework

    ERIC Educational Resources Information Center

    Gavin, K. G.

    2010-01-01

    This paper describes the design of the curriculum for a Master of Engineering programme in civil engineering at University College Dublin. The revised programme was established to meet the requirements of the Bologna process and this paper specifically considers the design of a new, second-cycle master's component of the programme. In addition to…

  6. Learning Networks--Enabling Change through Community Action Research

    ERIC Educational Resources Information Center

    Bleach, Josephine

    2016-01-01

    Learning networks are a critical element of ethos of the community action research approach taken by the Early Learning Initiative at the National College of Ireland, a community-based educational initiative in the Dublin Docklands. Key criteria for networking, whether at local, national or international level, are the individual's and…

  7. Stumbling on Aesthetic Experience: A Factual Account of the Accidental Discovery of Aesthetic Education in an Irish Context.

    ERIC Educational Resources Information Center

    Donnelly, Nora

    1990-01-01

    Describes how an elementary classroom teacher discovers and explores the power of aesthetic experience in an educational context. Discusses how the artwork of Vincent Van Gogh helps an exceptionally difficult class of 11-year-old female students in suburban Dublin, Ireland, become interested in their education. (KM)

  8. Re-Thinking Professional Development and Accountability: Towards a More Educational Training Practice

    ERIC Educational Resources Information Center

    Emmett, Yvonne

    2015-01-01

    In this article, I discuss the contribution of theoretical resources to the transformation in my thinking about professional development and accountability, within an action research self-study of practice as a civil servant, in the context of participation on the Doctor in Education (Leadership) programme at Dublin City University (DCU) in the…

  9. The Pedagogy of Protest: The Educational Thought and Work of Patrick H. Pearse

    ERIC Educational Resources Information Center

    Walsh, Brendan

    2007-01-01

    This book provides the first complete account of Patrick Pearse's educational work at St. Enda's and St. Ita's schools (Dublin). Extensive use of first-hand accounts reveals Pearse as a humane, energetic teacher and a forward-looking and innovative educational thinker. Between 1903 and 1916 Pearse developed a new concept of schooling as an agency…

  10. Universal Design for Learning and Its Application to Clinical Placements in Health Science Courses (Practice Brief)

    ERIC Educational Resources Information Center

    Heelan, Ann; Halligan, Phil; Quirke, Mary

    2015-01-01

    In 2013 Ireland's Association for Higher Education, Access and Disability (AHEAD), in partnership with the School of Nursing University College Dublin (UCD), hosted a summer school for professionals working in the Health Sciences sector who have responsibility for including students with disabilities in the health professions, including clinical…

  11. What is mLearning and How Can It Be Used to Support Learning and Teaching in Econometrics?

    ERIC Educational Resources Information Center

    Morales, Lucia

    2013-01-01

    The aim of case this study was to analyze the integration of mobile learning technologies in a postgraduate course in Finance (MSc in Finance) at Dublin Institute of Technology, where econometrics is an important course component. Previous experience with students undertaking econometrics modules supported this analysis, where the researcher…

  12. Informing and Evaluating a Metadata Initiative: Usability and Metadata Studies in Minnesota's "Foundations" Project.

    ERIC Educational Resources Information Center

    Quam, Eileen

    2001-01-01

    Explains Minnesota's Foundations Project, a multiagency collaboration to improve access to environmental and natural resources information. Discusses the use of the Dublin core metadata standard for Web resources and describes three studies that included needs assessment, Bridges Web site user interface, and usability of controlled vocabulary in…

  13. Association of Educational Attainment and Adolescent Substance Use Disorder in a Clinical Sample

    ERIC Educational Resources Information Center

    Apantaku-Olajide, Tunde; James, Philip D.; Smyth, Bobby P.

    2014-01-01

    This study explores substance use, psychosocial problems, and the relationships to educational status in 193 adolescents (school dropouts, 63; alternative education, 46; mainstream students, 84) who attended a substance abuse treatment facility in Dublin, Ireland, within a 42-month period. For each adolescent, data on demographics, family…

  14. Learning to Be an Information Architect

    ERIC Educational Resources Information Center

    Wusteman, Judith

    2013-01-01

    This article describes a recently introduced module at University College Dublin School of Information and Library Studies (SILS), entitled "Information Architecture: Designing the Web." The module provides students with a realistic experience of how information architects apply their skills to produce usable web sites, via a project to…

  15. "Bursting" to Go and Other Experiences: Children's Views on Using the Toilet in the First School Year

    ERIC Educational Resources Information Center

    Tatlow-Golden, Mimi; O'Farrelly, Christine; Booth, Ailbhe; Doyle, Orla

    2017-01-01

    Children's use of the toilet at school, although rarely explored, is an important facet of school experience with consequences for physical and psychological health. A mixed methods study investigated views of 25 children (4-5 years) regarding potential stressors in the first school year, including views of toileting, in Dublin, Ireland. Despite…

  16. Who Graduates from Irish Distance University Education?

    ERIC Educational Resources Information Center

    Delaney, Lorraine

    2015-01-01

    This paper outlines results from an online survey of recent distance graduates. The study, based in Dublin City University (DCU) addresses a gap in the research on this cohort of graduates. Findings indicate that distance graduates are primarily from lower socio economic backgrounds, a group largely under-represented in full-time university…

  17. Designing and Developing a Programme-Focused Assessment Strategy: A Case Study

    ERIC Educational Resources Information Center

    Brunton, James; Brown, Mark; Costello, Eamon; Walsh, Elaine

    2016-01-01

    This case study describes the process that the Humanities Programme Team, in Dublin City University's Open Education Unit, has undertaken with regard to developing a systematic, programme-focused assessment strategy. It charts the development of an Assessment Matrix that facilitated the enhancement of programme coherence in the context of a…

  18. Using Intrade.com to Teach Campaign Strategies in the 2008 U.S. Presidential Election

    ERIC Educational Resources Information Center

    Abramson, Paul R.

    2010-01-01

    During the six weeks before the 2008 elections, I conducted a contest for the 72 students enrolled in my upper-division course Campaigns and Elections. Using contract prices posted by Intrade.com, an electronic gaming market based in Dublin, I asked students to choose among 10 political outcomes. The "contracts" earned by each choice…

  19. Cataloging the Net: Can We Do It?

    ERIC Educational Resources Information Center

    Oder, Norman

    1998-01-01

    Discusses possibilities for cataloging Internet resources and the role that the library profession can play. Topics include the Dublin Core metadata; public library projects (Michigan Electronic Library "MEL" and Librarians' Index to the Internet "LII"); academic library projects (INFOMINE, Scout Report); commercial sites…

  20. Me and My Body (MAMBO): An Interactive Science Education Programme for Primary Schools

    ERIC Educational Resources Information Center

    Scalzo, Clare; Killard, Fiona; MacCormac, Aoife; Fryar, James; O' Brien, Emma; O'Kennedy, Richard

    2008-01-01

    This paper describes a novel science education initiative developed for 8-to 12-year-old children by the Biomedical Diagnostics Institute at Dublin City University, Ireland. "Me and My Body" (MAMBO) is an interactive, multi-faceted programme that enables children to explore and understand the dynamic physiological parameters of the human…

  1. The Competitive Struggle.

    ERIC Educational Resources Information Center

    Barry, Jeff; Bilal, Dania; Penniman, W. David

    1998-01-01

    Presents results of a survey of 30 library systems vendors to examine how successfully they met the key challenges of 1997: integration, testing, and marketing a new generation of systems. Character-based systems, the Dublin Core, Java, and the Z39.50 standard are discussed. Profiles describing sales and product developments for each of the…

  2. What Young People Say about Physical Activity: The Children's Sport Participation and Physical Activity (CSPPA) Study

    ERIC Educational Resources Information Center

    Tannehill, Deborah; MacPhail, Ann; Walsh, Julia; Woods, Catherine

    2015-01-01

    The Children's Sport Participation and Physical Activity (CSPPA) study is a unique multi-centre/discipline study undertaken by three Irish institutions, Dublin City University, University of Limerick and University College Cork. The study sought to assess participation in physical activity, physical education and sport (PAPES) among 10-18 year…

  3. Semantics for E-Learning: An Advanced Knowledge Management Oriented Metadata Schema for Learning Purposes.

    ERIC Educational Resources Information Center

    Lytras, Miltiadis D.

    The research described in this paper is concentrated on the demand for high quality interchangeable knowledge objects capable of supporting dynamic learning initiatives. The general metadata models (Dublin Core, IMS, LOM, SCORM) for knowledge objects enrichment are reviewed and a critique is provided in order to claim the importance of the…

  4. Establishing a Korean Language Programme in a European Higher Education Context: Rationale, Curriculum and Assessment Procedures

    ERIC Educational Resources Information Center

    Carson, Lorna; Do, Eunjee

    2013-01-01

    A growth in interest in Korean contemporary culture in Europe has benefitted Korean language studies in Higher Education. This article describes an innovative Korean language programme in the School of Linguistic, Speech and Communication Sciences at Trinity College Dublin, Ireland. Since its establishment as a pilot project in 2010, the Korean…

  5. Standardising Assessment to Meet Student Needs in Foreign Language Modules in a University Context: Is Standardisation Possible?

    ERIC Educational Resources Information Center

    Nunan, Anna

    2014-01-01

    The Applied Language Centre at University College Dublin offers foreign language modules to students in ten languages at CEFR [Common European Framework of Reference for Languages] levels ranging from A1 to B2. Efforts have been underway in the Centre to standardise the assessment components across languages to ensure parity between module credits…

  6. Digital Initiatives and Metadata Use in Thailand

    ERIC Educational Resources Information Center

    SuKantarat, Wichada

    2008-01-01

    Purpose: This paper aims to provide information about various digital initiatives in libraries in Thailand and especially use of Dublin Core metadata in cataloguing digitized objects in academic and government digital databases. Design/methodology/approach: The author began researching metadata use in Thailand in 2003 and 2004 while on sabbatical…

  7. The Role of Eportfolios in Finance Studies: A Cross-Country Study

    ERIC Educational Resources Information Center

    Domínguez, Amparo S.; Morales, Lucía; Tarkovska, Valentina

    2014-01-01

    This study explores the use of ePortfolios as an efficient assessment tool to support students pursuing a Business degree, where Finance is a major component. We conducted an analysis on the role of ePortfolios in Higher Education at Dublin Institute of Technology (Republic of Ireland) and at Universitat Jaume I (Spain) for undergraduate studies.…

  8. Transformative Learning for Counselor Trainees: Implementation of the Multicultural Immersion Experience Model

    ERIC Educational Resources Information Center

    Prosek, Elizabeth A.; Michel, Rebecca E.

    2016-01-01

    In this qualitative inquiry, we studied the lived experiences of counselor trainees who participated in a short-term study abroad program in Dublin, Ireland. It was found that counselor trainees self-reported transformative growth as a result of their cultural immersion. Specifically, counselor trainees identified an increase in cultural…

  9. Mothers Who Formula Feed: Their Practices, Support Needs and Factors Influencing Their Infant Feeding Decision

    ERIC Educational Resources Information Center

    Tarrant, Roslyn C.; Sheridan-Pereira, Margaret; McCarthy, Roberta A.; Younger, Katherine M.; Kearney, John M.

    2013-01-01

    The majority of mothers in Ireland provide formula milk to their infants during the initial weeks postpartum; however, data are lacking on their formula feeding practices and support needs. This prospective Dublin-based observational study, which included 450 eligible mother-term infant pairs recruited and followed up to six months postpartum,…

  10. Metadata Evaluation: The Road toward Meeting Our Objectives (SIG LAN)

    ERIC Educational Resources Information Center

    Cuddy, Colleen

    2000-01-01

    Lists the three presentation titles that were part of this technical session on metadata evaluation, including "An Update on the Dublin Core" (Stuart Weibel; "Metadata Development Update" (Kathleen Burnett and Jeong-Mee Lee); and "Metadata Standards for Discovery and Retrieval of Learning Objects" (Stuart Sutton).…

  11. The University and the State in a Global Age: Renegotiating the Traditional Social Contract?

    ERIC Educational Resources Information Center

    Kwiek, Marek

    2005-01-01

    This article is based on the Keynote Address to the European Conference on Educational Research (ECER), Dublin, Ireland, 7-10 September 2005. It argues that we are facing the simultaneous renegotiation of the major post-war social contract (concerning the welfare state) in Europe and the renegotiation of a smaller-scale modern social pact: the…

  12. Report from the European Prison Education Association, September 2006

    ERIC Educational Resources Information Center

    Behan, Cormac

    2006-01-01

    This article reports that the 11th European Prison Education Association International Conference will take place in Dublin, Ireland from June 13 to June 17, 2007. The conference, which was titled "Learning for Liberation," will focus on the exploration of what adult education can offer prison/correctional education. This article also presents the…

  13. Brief Report: A Case-Control Study of Obstetric Complications and Later Autistic Disorder.

    ERIC Educational Resources Information Center

    Cryan, Elizabeth; And Others

    1996-01-01

    Contemporaneous birth records of 49 Dublin (Ireland) children with autism were compared to those of the previous same-sex live birth for maternal age, maternal parity, birth order, and birth weight. Autistic individuals did not differ from controls in terms of risk factors for autism associated with obstetric adversity, disputing the view that…

  14. Australian Core Catholic Youth, Catholic Schools and Religious Education

    ERIC Educational Resources Information Center

    Rymarz, Richard; Graham, John

    2006-01-01

    This paper reports on research on the attitudes of a differentiated sample of students to Catholic schools in general and religious education in particular. Core Catholic youth are described, following Fulton "et al." (2000: "Young Catholics at the New Millennium", Dublin, University College Press), as individuals who have an…

  15. Steering the Ark: A Cultural Center for Children

    ERIC Educational Resources Information Center

    Drury, Martin

    2006-01-01

    In this article, the author reflects on his experience developing and running The Ark, a Cultural Center for Children in Dublin, Ireland. The author describes the practice and ten guiding principles behind the center. While acknowledging that arts education and arts practice for and with young people is a rich and varied landscape, within which a…

  16. Integrating Personal Development and Career Planning: The Outcomes for First Year Undergraduate Learning

    ERIC Educational Resources Information Center

    Monks, Kathy; Conway, Edel; Dhuigneain, Muireann Ni

    2006-01-01

    This article describes the way in which colleagues from the Business faculty, the Careers Service and the Library at Dublin City University collaborated to design and deliver an integrated approach to personal development planning (PDP) with the aim of motivating first year undergraduate students to take greater responsibility for their own…

  17. Descriptive Metadata: Emerging Standards.

    ERIC Educational Resources Information Center

    Ahronheim, Judith R.

    1998-01-01

    Discusses metadata, digital resources, cross-disciplinary activity, and standards. Highlights include Standard Generalized Markup Language (SGML); Extensible Markup Language (XML); Dublin Core; Resource Description Framework (RDF); Text Encoding Initiative (TEI); Encoded Archival Description (EAD); art and cultural-heritage metadata initiatives;…

  18. Searchers Net Treasure in Monterey.

    ERIC Educational Resources Information Center

    McDermott, Irene E.

    1999-01-01

    Reports on Web keyword searching, metadata, Dublin Core, Extensible Markup Language (XML), metasearch engines (metasearch engines search several Web indexes and/or directories and/or Usenet and/or specific Web sites), and the Year 2000 (Y2K) dilemma, all topics discussed at the second annual Internet Librarian Conference sponsored by Information…

  19. 4(th) HUPO Brain Proteome Project Workshop in Munich, Germany.

    PubMed

    Hamacher, Michael; Stephan, Christian; Palacios Bustamante, Nadine; van Hall, Andre; Marcus, Katrin; Meyer, Helmut E

    2006-01-01

    More than 70 interested colleagues attended the 4(th) Workshop of HUPO's Brain Proteome Project. The project was presented within nine talks mainly focusing on two running pilot studies as well as on data re-processing. A bioinformatics jamboree in Hinxton, UK, and the 5th Workshop taking place in Dublin next February were announced.

  20. Metadata Leadership

    ERIC Educational Resources Information Center

    Tennant, Roy

    2004-01-01

    Libraries must increasingly accommodate bibliographic records encoded with a variety of standards and emerging standards, including Dublin Core, MODS, and VRA Core. The problem is that many libraries still rely solely on MARC and AACR2. The best-trained professionals to lead librarians through the metadata maze are catalogers. Catalogers…