Sample records for human population explosion

  1. Explosive genetic evidence for explosive human population growth

    PubMed Central

    Gao, Feng; Keinan, Alon

    2016-01-01

    The advent of next-generation sequencing technology has allowed the collection of vast amounts of genetic variation data. A recurring discovery from studying larger and larger samples of individuals had been the extreme, previously unexpected, excess of very rare genetic variants, which has been shown to be mostly due to the recent explosive growth of human populations. Here, we review recent literature that inferred recent changes in population size in different human populations and with different methodologies, with many pointing to recent explosive growth, especially in European populations for which more data has been available. We also review the state-of-the-art methods and software for the inference of historical population size changes that lead to these discoveries. Finally, we discuss the implications of recent population growth on personalized genomics, on purifying selection in the non-equilibrium state it entails and, as a consequence, on the genetic architecture underlying complex disease and the performance of mapping methods in discovering rare variants that contribute to complex disease risk. PMID:27710906

  2. Epidemiological studies on radiation carcinogenesis in human populations following acute exposure: nuclear explosions and medical radiation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fabrikant, J.I.

    1981-05-01

    The current knowledge of the carcinogenic effect of radiation in man is considered. The discussion is restricted to dose-incidence data in humans, particularly to certain of those epidemiological studies of human populations that are used most frequently for risk estimation for low-dose radiation carcinogenesis in man. Emphasis is placed solely on those surveys concerned with nuclear explosions and medical exposures. (ACR)

  3. Selection and explosive growth alter genetic architecture and hamper the detection of causal rare variants

    PubMed Central

    Zaitlen, Noah A.; Ye, Chun Jimmie; Witte, John S.

    2016-01-01

    The role of rare alleles in complex phenotypes has been hotly debated, but most rare variant association tests (RVATs) do not account for the evolutionary forces that affect genetic architecture. Here, we use simulation and numerical algorithms to show that explosive population growth, as experienced by human populations, can dramatically increase the impact of very rare alleles on trait variance. We then assess the ability of RVATs to detect causal loci using simulations and human RNA-seq data. Surprisingly, we find that statistical performance is worst for phenotypes in which genetic variance is due mainly to rare alleles, and explosive population growth decreases power. Although many studies have attempted to identify causal rare variants, few have reported novel associations. This has sometimes been interpreted to mean that rare variants make negligible contributions to complex trait heritability. Our work shows that RVATs are not robust to realistic human evolutionary forces, so general conclusions about the impact of rare variants on complex traits may be premature. PMID:27197206

  4. Selection and explosive growth alter genetic architecture and hamper the detection of causal rare variants.

    PubMed

    Uricchio, Lawrence H; Zaitlen, Noah A; Ye, Chun Jimmie; Witte, John S; Hernandez, Ryan D

    2016-07-01

    The role of rare alleles in complex phenotypes has been hotly debated, but most rare variant association tests (RVATs) do not account for the evolutionary forces that affect genetic architecture. Here, we use simulation and numerical algorithms to show that explosive population growth, as experienced by human populations, can dramatically increase the impact of very rare alleles on trait variance. We then assess the ability of RVATs to detect causal loci using simulations and human RNA-seq data. Surprisingly, we find that statistical performance is worst for phenotypes in which genetic variance is due mainly to rare alleles, and explosive population growth decreases power. Although many studies have attempted to identify causal rare variants, few have reported novel associations. This has sometimes been interpreted to mean that rare variants make negligible contributions to complex trait heritability. Our work shows that RVATs are not robust to realistic human evolutionary forces, so general conclusions about the impact of rare variants on complex traits may be premature. © 2016 Uricchio et al.; Published by Cold Spring Harbor Laboratory Press.

  5. Learning That Makes a Difference: Pedagogy and Practice for Learning Abroad

    ERIC Educational Resources Information Center

    Benham Rennick, Joanne

    2015-01-01

    Society faces significant new challenges surrounding issues in human health; global security; environmental devastation; human rights violations; economic uncertainty; population explosion and regression; recognition of diversity, difference and special populations at home and abroad. In light of these challenges, there is a great opportunity, and…

  6. Epidemiological studies on radiation carcinogenesis in human populations following acute exposure: nuclear explosions and medical radiation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fabrikant, J.I.

    1982-08-01

    The present review provides an understanding of our current knowledge of the carcinogenic effect of low-dose radiation in man, and surveys the epidemiological studies of human populations exposed to nuclear explosions and medical radiation. Discussion centers on the contributions of quantitative epidemiology to present knowledge, the reliability of the dose-incidence data, and those relevant epidemiological studies that provide the most useful information for risk estimation of cancer-induction in man. Reference is made to dose-incidence relationships from laboratory animal experiments where they may obtain for problems and difficulties in extrapolation from data obtained at high doses to low doses, and frommore » animal data to the human situation. The paper describes the methods of application of such epidemiological data for estimation of excess risk of radiation-induced cancer in exposed human populations, and discusses the strengths and limitations of epidemiology in guiding radiation protection philosophy and public health policy.« less

  7. Epidemiological studies on radiation carcinogenesis in human populations following acute exposure: nuclear explosions and medical radiation.

    PubMed Central

    Fabrikant, J. I.

    1981-01-01

    The present review provides an understanding of our current knowledge of the carcinogenic effect of low-dose radiation in man, and surveys the epidemiological studies of human populations exposed to nuclear explosions and medical radiation. Discussion centers on the contributions of quantitative epidemiology to present knowledge, the reliability of the dose-incidence data, and those relevant epidemiological studies that provide the most useful information for risk estimation of cancer induction in man. Reference is made to dose-incidence relationships from laboratory animal experiments where they may obtain, for problems and difficulties in extrapolation from data obtained at high doses to low doses, and from animal data to the human situation. The paper describes the methods of application of such epidemiological data for estimation of excess risk of radiation-induced cancer in exposed human populations and discusses the strengths and limitations of epidemiology in guiding radiation protection philosophy and public health policy. PMID:7043913

  8. Methods Needed to Curb Rising Pet Population

    ERIC Educational Resources Information Center

    Chemical and Engineering News, 1973

    1973-01-01

    Discusses socioeconomic problems of pet population explosion and recommends the conduct of educational programs and the implementation of surgical sterilization as a short-term answer to dog and cat control. Also considered are problems of using chemical contraceptives in human population control. (CC)

  9. System for ranking relative threats of U.S. volcanoes

    USGS Publications Warehouse

    Ewert, J.W.

    2007-01-01

    A methodology to systematically rank volcanic threat was developed as the basis for prioritizing volcanoes for long-term hazards evaluations, monitoring, and mitigation activities. A ranking of 169 volcanoes in the United States and the Commonwealth of the Northern Mariana Islands (U.S. volcanoes) is presented based on scores assigned for various hazard and exposure factors. Fifteen factors define the hazard: Volcano type, maximum known eruptive explosivity, magnitude of recent explosivity within the past 500 and 5,000 years, average eruption-recurrence interval, presence or potential for a suite of hazardous phenomena (pyroclastic flows, lahars, lava flows, tsunami, flank collapse, hydrothermal explosion, primary lahar), and deformation, seismic, or degassing unrest. Nine factors define exposure: a measure of ground-based human population in hazard zones, past fatalities and evacuations, a measure of airport exposure, a measure of human population on aircraft, the presence of power, transportation, and developed infrastructure, and whether or not the volcano forms a significant part of a populated island. The hazard score and exposure score for each volcano are multiplied to give its overall threat score. Once scored, the ordered list of volcanoes is divided into five overall threat categories from very high to very low. ?? 2007 ASCE.

  10. Necrotic enteritis: important role of intestinal immunity to Clostridium perfringens in pathogenesis and antibiotic alternative strategies to reduce the gut damage

    USDA-ARS?s Scientific Manuscript database

    The human population is projected to grow to 9-10 billion by the year 2050. As a consequence of the population explosion, food animal production must confront a new array of challenges including global food security, regulatory ban of antimicrobials, climate change, emerging infectious diseases, hi...

  11. Maintenance energy requirements of odor detection, explosive detection and human detection working dogs.

    PubMed

    Mullis, Rebecca A; Witzel, Angela L; Price, Joshua

    2015-01-01

    Despite their important role in security, little is known about the energy requirements of working dogs such as odor, explosive and human detection dogs. Previous researchers have evaluated the energy requirements of individual canine breeds as well as dogs in exercise roles such as sprint racing. This study is the first to evaluate the energy requirements of working dogs trained in odor, explosive and human detection. This retrospective study evaluated twenty adult dogs who maintained consistent body weights over a six month period. During this time, the average energy consumption was [Formula: see text] or two times the calculated resting energy requirement ([Formula: see text]). No statistical differences were found between breeds, age or sex, but a statistically significant association (p = 0.0033, R-square = 0.0854) was seen between the number of searches a dog performs and their energy requirement. Based on this study's population, it appears that working dogs have maintenance energy requirements similar to the 1974 National Research Council's (NRC) maintenance energy requirement of [Formula: see text] (National Research Council (NRC), 1974) and the [Formula: see text] reported for young laboratory beagles (Rainbird & Kienzle, 1990). Additional research is needed to determine if these data can be applied to all odor, explosive and human detection dogs and to determine if other types of working dogs (tracking, search and rescue etc.) have similar energy requirements.

  12. Deregulating Low-Risk Research

    ERIC Educational Resources Information Center

    Shamoo, Adil E.

    2007-01-01

    In the past few decades, with the explosion of biotechnology and the aging of the population, the use of human subjects in research has increased significantly. The United States has done much to protect human research subjects, and no one can deny the importance of keeping them safe. But at the same time, researchers whose work poses no threat to…

  13. Dietary phytonutrients enhance gut innate immunity, modulate gut microbiota and improve disease resistance to coccidiosis and necrotic enteritis in broiler chickens

    USDA-ARS?s Scientific Manuscript database

    The human population is projected to grow to 9-10 billion by the year 2050. As a consequence of the population explosion, food animal production must confront a new array of challenges. Among these are global food security, climate change, emerging infectious diseases, regulatory ban of antimicrobi...

  14. The Discovery of America

    ERIC Educational Resources Information Center

    Martin, Paul S.

    1973-01-01

    Discusses a model for explaining the spread of human population explosion on North American continent since its discovery 12,000 years ago. The model may help to map the spread of Homo sapiens throughout the New World by using the extinction chronology of the Pleistocene megafauna. (Author/PS)

  15. Drought, Mortality and Social Structure.

    ERIC Educational Resources Information Center

    Sharma, Sanjay

    1995-01-01

    Examines the relationship between the human population explosion, resource depletion, drought, malnutrition, and disease. As a sample study, mortality trends in Rajasthan State in India in the 1980s were analyzed to correlate the increased death rate with the drought of 1987. It is demonstrated that drought-induced malnutrition was the root cause…

  16. Thoughts for 1972 - Living Dangerously in the Age of Science

    ERIC Educational Resources Information Center

    Rabinowitch, Eugene

    1972-01-01

    Whether mankind will be successful in taming the three apocalyptic horses of the technological age--nuclear war, population explosion and destruction of the human habitat--depends on sufficiently rapid transportation of the body of knowledge and the pattern of attitudes we transmit to coming generations ... widespread transition from qualitative…

  17. Origin, Spread and Demography of the Mycobacterium tuberculosis Complex

    PubMed Central

    Wirth, Thierry; Hildebrand, Falk; Allix-Béguec, Caroline; Wölbeling, Florian; Kubica, Tanja; Kremer, Kristin; van Soolingen, Dick; Rüsch-Gerdes, Sabine; Locht, Camille; Brisse, Sylvain; Meyer, Axel

    2008-01-01

    The evolutionary timing and spread of the Mycobacterium tuberculosis complex (MTBC), one of the most successful groups of bacterial pathogens, remains largely unknown. Here, using mycobacterial tandem repeat sequences as genetic markers, we show that the MTBC consists of two independent clades, one composed exclusively of M. tuberculosis lineages from humans and the other composed of both animal and human isolates. The latter also likely derived from a human pathogenic lineage, supporting the hypothesis of an original human host. Using Bayesian statistics and experimental data on the variability of the mycobacterial markers in infected patients, we estimated the age of the MTBC at 40,000 years, coinciding with the expansion of “modern” human populations out of Africa. Furthermore, coalescence analysis revealed a strong and recent demographic expansion in almost all M. tuberculosis lineages, which coincides with the human population explosion over the last two centuries. These findings thus unveil the dynamic dimension of the association between human host and pathogen populations. PMID:18802459

  18. AIDS and population "control".

    PubMed

    Piel, G

    1994-02-01

    Many people believe that the AIDS pandemic will end the population explosion, especially in Africa, where population growth is very high and poverty reigns. Africans make up 10 million of all 15 million HIV- infected persons worldwide. Yet, the proposition that AIDS will sole population explosion does not stand up to reason. About 200 million people in Africa will be HIV infected by 2010, but the loss of 200 million people would not slow population growth. The 14th century's Black Death killed more than 50% of the European population, but by 1750 Europe had reached the population size it would have reached without the Black Death. The 200 million people who died violent deaths between the start and end of the two World Wars did not stop world population growth from peaking in 1970 at about 2%. When Malthus made his prediction that human population would crash, the industrial revolution had already helped production outrun population growth. Today all industrial countries are either at or near zero population growth and have completed the demographic transition (from near zero growth in 1600 with high births and death rates and a 25-year life expectancy, to near zero growth in 1990s at low death and birth rates with a 75-year life expectancy). Mass education, sanitation, primary medicine, and the green revolution have already reduced death rates and increased life expectancy in developing countries. Thus, they have entered the first phase of the demographic transition. Some developing countries are in the second phase; birth rate decline For example, in India and China, fertility has fallen from 6 to 4 in India and is at 2.3 in China. The AIDS pandemic is a diversion of physical and human resources from helping developing countries pass through the demographic transition more quickly to achieve sustainable development. This delay is likely to effect a larger maximum population. The industrial revolution has shifted the key to stopping population growth the people dying to people living.

  19. The Military in Disaster Relief After the Explosion in Halifax, Nova Scotia, December 1917

    DTIC Science & Technology

    2017-06-09

    Scotia. The blast had one- sixth the power of the first atomic bomb and killed or wounded 20 percent of the Halifax population. The enormous ensuing...in Halifax, Nova Scotia. The blast had one-sixth the power of the first atomic bomb and killed or wounded 20 percent of the Halifax population. The...Simpson and Alan Ruffman, “Explosions, Bombs , and Bumps: Scientific Aspects of the Explosion,” in Ground Zero: A Reassessment of the 1917 Explosion in

  20. Individual heterogeneity generating explosive system network dynamics.

    PubMed

    Manrique, Pedro D; Johnson, Neil F

    2018-03-01

    Individual heterogeneity is a key characteristic of many real-world systems, from organisms to humans. However, its role in determining the system's collective dynamics is not well understood. Here we study how individual heterogeneity impacts the system network dynamics by comparing linking mechanisms that favor similar or dissimilar individuals. We find that this heterogeneity-based evolution drives an unconventional form of explosive network behavior, and it dictates how a polarized population moves toward consensus. Our model shows good agreement with data from both biological and social science domains. We conclude that individual heterogeneity likely plays a key role in the collective development of real-world networks and communities, and it cannot be ignored.

  1. Individual heterogeneity generating explosive system network dynamics

    NASA Astrophysics Data System (ADS)

    Manrique, Pedro D.; Johnson, Neil F.

    2018-03-01

    Individual heterogeneity is a key characteristic of many real-world systems, from organisms to humans. However, its role in determining the system's collective dynamics is not well understood. Here we study how individual heterogeneity impacts the system network dynamics by comparing linking mechanisms that favor similar or dissimilar individuals. We find that this heterogeneity-based evolution drives an unconventional form of explosive network behavior, and it dictates how a polarized population moves toward consensus. Our model shows good agreement with data from both biological and social science domains. We conclude that individual heterogeneity likely plays a key role in the collective development of real-world networks and communities, and it cannot be ignored.

  2. Toward a psychology of human survival: Psychological approaches to contemporary global threats

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Walsh, R.

    Nuclear weapons, population explosion, resource and food-supply depletion, and environmental deterioration have been posing increasing threats to human survival. Moreover, for the first time in history, all these major global threats are human caused and can, therefore, be traced in large part to psychological origins. After a brief overview of the nature and extent of current threats, this paper suggests criteria for an adequate psychology of human survival. The causes and effects of the threats are examined from various psychological perspectives and the psychological principles underlying effective responses are deduced. The ways in which mental health professionals may contribute tomore » this most crucial task are discussed. 76 references.« less

  3. A pulse of mid-Pleistocene rift volcanism in Ethiopia at the dawn of modern humans.

    PubMed

    Hutchison, William; Fusillo, Raffaella; Pyle, David M; Mather, Tamsin A; Blundy, Jon D; Biggs, Juliet; Yirgu, Gezahegn; Cohen, Benjamin E; Brooker, Richard A; Barfod, Dan N; Calvert, Andrew T

    2016-10-18

    The Ethiopian Rift Valley hosts the longest record of human co-existence with volcanoes on Earth, however, current understanding of the magnitude and timing of large explosive eruptions in this region is poor. Detailed records of volcanism are essential for interpreting the palaeoenvironments occupied by our hominin ancestors; and also for evaluating the volcanic hazards posed to the 10 million people currently living within this active rift zone. Here we use new geochronological evidence to suggest that a 200 km-long segment of rift experienced a major pulse of explosive volcanic activity between 320 and 170 ka. During this period, at least four distinct volcanic centres underwent large-volume (>10 km 3 ) caldera-forming eruptions, and eruptive fluxes were elevated five times above the average eruption rate for the past 700 ka. We propose that such pulses of episodic silicic volcanism would have drastically remodelled landscapes and ecosystems occupied by early hominin populations.

  4. A pulse of mid-Pleistocene rift volcanism in Ethiopia at the dawn of modern humans

    PubMed Central

    Hutchison, William; Fusillo, Raffaella; Pyle, David M.; Mather, Tamsin A.; Blundy, Jon D.; Biggs, Juliet; Yirgu, Gezahegn; Cohen, Benjamin E.; Brooker, Richard A.; Barfod, Dan N.; Calvert, Andrew T.

    2016-01-01

    The Ethiopian Rift Valley hosts the longest record of human co-existence with volcanoes on Earth, however, current understanding of the magnitude and timing of large explosive eruptions in this region is poor. Detailed records of volcanism are essential for interpreting the palaeoenvironments occupied by our hominin ancestors; and also for evaluating the volcanic hazards posed to the 10 million people currently living within this active rift zone. Here we use new geochronological evidence to suggest that a 200 km-long segment of rift experienced a major pulse of explosive volcanic activity between 320 and 170 ka. During this period, at least four distinct volcanic centres underwent large-volume (>10 km3) caldera-forming eruptions, and eruptive fluxes were elevated five times above the average eruption rate for the past 700 ka. We propose that such pulses of episodic silicic volcanism would have drastically remodelled landscapes and ecosystems occupied by early hominin populations. PMID:27754479

  5. Balancing conservation management and tourism development with wilderness stewardship in the Kruger National Park, South Africa

    Treesearch

    F. J. (Freek) Venter

    2007-01-01

    The Kruger National Park (KNP) faces greatly amplified problems than was the case in the early 1900s when the KNP was established. Areas surrounding the park have experienced a human population explosion with a rapid expansion of farming areas and rural settlements. In the 1970s the KNP was fenced. Ecologically the KNP became an island and previous regional animal...

  6. Impact of ammunition and military explosives on human health and the environment.

    PubMed

    Lima, Débora R S; Bezerra, Marcio L S; Neves, Eduardo B; Moreira, Fátima R

    2011-01-01

    To review the literature concerning the risks associated with the main xenobiotics contained in military ammunition and explosive residues and damage to human and environmental health. Using "ammunition", "military", "environmental", "health", "explosive", "metal", "TNT", "RDX", "pollution", and "contamination" as search terms, a large database, namely ISI Web of Knowledge and PubMed, was searched for studies on military ammunition and explosive residues from 1989 to 2010. Other sources used to conduct the search included the library of the Toxicology Laboratory of the Center for Workers' Health and Human Ecology (CESTEH) at the National School of Public Health. In total, 15 different combinations were used with the search words above and 708 papers were found. Among them, 76 papers concerned this review. More than 12 references of interest were discovered in the library of the CESTEH. The results were organized into metals, dinitrotoluene, trinitrotoluene (TNT), and royal demolition explosive (RDX), showing their main uses, occurrence in the environment, the current toxic effects to human and environmental health, and remediation possibilities. Because military activities can cause the acute and chronic exposure of human beings, the public administration must aim politics towards suitable environmental management.

  7. Reducing the Impact of Attacks against Healthcare by Curbing the Use of Explosive Weapons in Populated Areas: Developments at the Global Level.

    PubMed

    Bagshaw, Simon

    Attacks against healthcare in situations of armed conflict have emerged as an issue of increasing concern with explosive weapons - such as aircraft bombs, mortars and improvised explosive devices - accounting for more deaths, injuries and damage than any other type of weapon in attacks on healthcare facilities. While this is perhaps unsurprising, it offers some insight into a possible course of action for dealing with the problem of attacks against healthcare - by curbing the use of explosive weapons in populated areas. There has been growing recognition in recent years of the humanitarian problems caused by the use of such weapons in populated areas. Steps are now being taken at the global level to curb this use which could, in time, make an important contribution to reducing the incidence and devastating impact of attacks against healthcare.

  8. Overpopulation question is complex, scientist says.

    PubMed

    Bauman, J

    1998-03-13

    This article presents Joel E. Cohen's lecture on the issue of population growth. Cohen, a professor at Rockefeller and Columbia universities, outlined the complexities involved in estimating the world's ability to support humans. He noted that the world has undergone a startling population explosion, with the total number of humans expected to surpass 6 billion in 1998, doubling the population size in only 40 years. Estimates of the total number of humans the planet can support have been varied over the years. However, the only constant element is that there is a wide gap between the standard of living in rich countries with relatively slow population growth and poor countries, where the population is booming. Statistics compiled in the 1960s, 1970s, 1980s, and 1990s attest to this fact. In addition, demographers show that food supply is not a good indicator of how many people an area can support and the fact that food prices are low does not indicate that there is no scarcity. Hence, there is a need to cope with the flourishing worldwide population. To do this, people should understand the complicated relationship between the physical constraints of the planet's carrying capacity and the choices that people must make. Cohen advocated for an improvement in the world's economic climate through better trade relations between developed and poorer countries.

  9. Energy Partitioning of Seismic Phases: Current Datasets and Techniques Aimed at Improving the Future of Event Identification

    NASA Astrophysics Data System (ADS)

    Bonner, J.

    2006-05-01

    Differences in energy partitioning of seismic phases from earthquakes and explosions provide the opportunity for event identification. In this talk, I will briefly review teleseismic Ms:mb and P/S ratio techniques that help identify events based on differences in compressional, shear, and surface wave energy generation from explosions and earthquakes. With the push to identify smaller yield explosions, the identification process has become increasingly complex as varied types of explosions, including chemical, mining, and nuclear, must be identified at regional distances. Thus, I will highlight some of the current views and problems associated with the energy partitioning of seismic phases from single- and delay-fired chemical explosions. One problem yet to have a universally accepted answer is whether the explosion and earthquake populations, based on the Ms:mb discriminants, should be separated at smaller magnitudes. I will briefly describe the datasets and theory that support either converging or parallel behavior of these populations. Also, I will discuss improvement to the currently used methods that will better constrain this problem in the future. I will also discuss the role of regional P/S ratios in identifying explosions. In particular, recent datasets from South Africa, Scandinavia, and the Western United States collected from earthquakes, single-fired chemical explosions, and/or delay-fired mining explosions have provide new insight into regional P, S, Lg, and Rg energy partitioning. Data from co-located mining and chemical explosions suggest that some mining explosions may be used for limited calibration of regional discriminants in regions where no historic explosion data is available.

  10. Human Social Behavior and Demography Drive Patterns of Fine-Scale Dengue Transmission in Endemic Areas of Colombia

    PubMed Central

    Padmanabha, Harish; Correa, Fabio; Rubio, Camilo; Baeza, Andres; Osorio, Salua; Mendez, Jairo; Jones, James Holland; Diuk-Wasser, Maria A

    2015-01-01

    Dengue is known to transmit between humans and A. aegypti mosquitoes living in neighboring houses. Although transmission is thought to be highly heterogeneous in both space and time, little is known about the patterns and drivers of transmission in groups of houses in endemic settings. We carried out surveys of PCR positivity in children residing in 2-block patches of highly endemic cities of Colombia. We found high levels of heterogeneity in PCR positivity, varying from less than 30% in 8 of the 10 patches to 56 and 96%, with the latter patch containing 22 children simultaneously PCR positive (PCR22) for DEN2. We then used an agent-based model to assess the likely eco-epidemiological context of this observation. Our model, simulating daily dengue dynamics over a 20 year period in a single two block patch, suggests that the observed heterogeneity most likely derived from variation in the density of susceptible people. Two aspects of human adaptive behavior were critical to determining this density: external social relationships favoring viral introduction (by susceptible residents or infectious visitors) and immigration of households from non-endemic areas. External social relationships generating frequent viral introduction constituted a particularly strong constraint on susceptible densities, thereby limiting the potential for explosive outbreaks and dampening the impact of heightened vectorial capacity. Dengue transmission can be highly explosive locally, even in neighborhoods with significant immunity in the human population. Variation among neighborhoods in the density of local social networks and rural-to-urban migration is likely to produce significant fine-scale heterogeneity in dengue dynamics, constraining or amplifying the impacts of changes in mosquito populations and cross immunity between serotypes. PMID:26656072

  11. Human Social Behavior and Demography Drive Patterns of Fine-Scale Dengue Transmission in Endemic Areas of Colombia.

    PubMed

    Padmanabha, Harish; Correa, Fabio; Rubio, Camilo; Baeza, Andres; Osorio, Salua; Mendez, Jairo; Jones, James Holland; Diuk-Wasser, Maria A

    2015-01-01

    Dengue is known to transmit between humans and A. aegypti mosquitoes living in neighboring houses. Although transmission is thought to be highly heterogeneous in both space and time, little is known about the patterns and drivers of transmission in groups of houses in endemic settings. We carried out surveys of PCR positivity in children residing in 2-block patches of highly endemic cities of Colombia. We found high levels of heterogeneity in PCR positivity, varying from less than 30% in 8 of the 10 patches to 56 and 96%, with the latter patch containing 22 children simultaneously PCR positive (PCR22) for DEN2. We then used an agent-based model to assess the likely eco-epidemiological context of this observation. Our model, simulating daily dengue dynamics over a 20 year period in a single two block patch, suggests that the observed heterogeneity most likely derived from variation in the density of susceptible people. Two aspects of human adaptive behavior were critical to determining this density: external social relationships favoring viral introduction (by susceptible residents or infectious visitors) and immigration of households from non-endemic areas. External social relationships generating frequent viral introduction constituted a particularly strong constraint on susceptible densities, thereby limiting the potential for explosive outbreaks and dampening the impact of heightened vectorial capacity. Dengue transmission can be highly explosive locally, even in neighborhoods with significant immunity in the human population. Variation among neighborhoods in the density of local social networks and rural-to-urban migration is likely to produce significant fine-scale heterogeneity in dengue dynamics, constraining or amplifying the impacts of changes in mosquito populations and cross immunity between serotypes.

  12. A Review of the Current Status of Relevant Zoonotic Pathogens in Wild Swine (Sus scrofa) Populations: Changes Modulating the Risk of Transmission to Humans.

    PubMed

    Ruiz-Fons, F

    2017-02-01

    Many wild swine populations in different parts of the World have experienced an unprecedented demographic explosion that may result in increased exposure of humans to wild swine zoonotic pathogens. Interactions between humans and wild swine leading to pathogen transmission could come from different ways, being hunters and game professionals the most exposed to acquiring infections from wild swine. However, increasing human settlements in semi-natural areas, outdoor activities, socio-economic changes and food habits may increase the rate of exposure to wild swine zoonotic pathogens and to potentially emerging pathogens from wild swine. Frequent and increasing contact rate between humans and wild swine points to an increasing chance of zoonotic pathogens arising from wild swine to be transmitted to humans. Whether this frequent contact could lead to new zoonotic pathogens emerging from wild swine to cause human epidemics or emerging disease outbreaks is difficult to predict, and assessment should be based on thorough epidemiologic surveillance. Additionally, several gaps in knowledge on wild swine global population dynamics trends and wild swine-zoonotic pathogen interactions should be addressed to correctly assess the potential role of wild swine in the emergence of diseases in humans. In this work, viruses such as hepatitis E virus, Japanese encephalitis virus, Influenza virus and Nipah virus, and bacteria such as Salmonella spp., Shiga toxin-producing Escherichia coli, Campylobacter spp. and Leptospira spp. have been identified as the most prone to be transmitted from wild swine to humans on the basis of geographic spread in wild swine populations worldwide, pathogen circulation rates in wild swine populations, wild swine population trends in endemic areas, susceptibility of humans to infection, transmissibility from wild swine to humans and existing evidence of wild swine-human transmission events. © 2015 Blackwell Verlag GmbH.

  13. Evaluation of active and passive near-millimeter-wave radiometric imaging techniques for detection of concealed objects

    NASA Astrophysics Data System (ADS)

    Reber, E. E.; Foote, F. B.; Schellenbaum, R. L.; Bradley, R. G.

    1981-07-01

    The potential of radiometric imaging technique to detect shielded nuclear materials and explosives carried covertly by personnel was investigated. This method of detecting contraband depends upon the differences in emissivity and reflectivity of the contraband relative to human tissue. Explosives, unlike metals and metal composites, generally have high emissivities and low reflectivities that closely approximate those of human tissue making explosives difficult to detect. Samples of several common types of explosives (TNT, Detasheet, C4, and several types of water gels) were examined at the 1.4- and 3-mm wavelengths using active and passive radiometeric techniques.

  14. Explosive laser

    DOEpatents

    Robinson, C.P.; Jensen, R.J.; Davis, W.C.; Sullivan, J.A.

    1975-09-01

    This patent relates to a laser system wherein reaction products from the detonation of a condensed explosive expand to form a gaseous medium with low translational temperature but high vibration population. Thermal pumping of the upper laser level and de-excitation of the lower laser level occur during the expansion, resulting in a population inversion. The expansion may be free or through a nozzle as in a gas-dynamic configuration. In one preferred embodiment, the explosive is such that its reaction products are CO$sub 2$ and other species that are beneficial or at least benign to CO$sub 2$ lasing. (auth)

  15. Rapid Molecular Detection Methods for Arboviruses of Livestock of Importance to Northern Europe

    PubMed Central

    Johnson, Nicholas; Voller, Katja; Phipps, L. Paul; Mansfield, Karen; Fooks, Anthony R.

    2012-01-01

    Arthropod-borne viruses (arboviruses) have been responsible for some of the most explosive epidemics of emerging infectious diseases over the past decade. Their impact on both human and livestock populations has been dramatic. The early detection either through surveillance or diagnosis of virus will be a critical feature in responding and resolving the emergence of such epidemics in the future. Although some of the most important emerging arboviruses are human pathogens, this paper aims to highlight those diseases that primarily affect livestock, although many are zoonotic and some occasionally cause human mortality. This paper also highlights the molecular detection methods specific to each virus and identifies those emerging diseases for which a rapid detection methods are not yet developed. PMID:22219660

  16. An unusual case of carbon monoxide poisoning.

    PubMed Central

    Auger, P L; Levesque, B; Martel, R; Prud'homme, H; Bellemare, D; Barbeau, C; Lachance, P; Rhainds, M

    1999-01-01

    Carbon monoxide, a gas originating from incomplete combustion of carbon-based fuels, is an important cause of human deaths. In this paper, we describe an unusual carbon monoxide poisoning in a dwelling without obvious sources of combustion gases, for which two adults had to be treated in a hyperbaric chamber. Carbon monoxide readings were taken in the house and in the neighboring homes. Methane gas and nitrogen oxide levels were also monitored in the house air. Soil samples were collected around the house and tested for hydrocarbon residues. The investigation revealed the presence of a pocket of carbon monoxide under the foundation of the house. The first readings revealed carbon monoxide levels of 500 ppm in the basement. The contamination lasted for a week. The investigation indicated that the probable source of contamination was the use of explosives at a nearby rain sewer construction site. The use of explosives in a residential area can constitute a major source of carbon monoxide for the neighboring populations. This must be investigated, and public health authorities, primary-care physicians, governmental authorities, and users and manufacturers of explosives must be made aware of this problem. Images Figure 1 Figure 2 PMID:10379009

  17. Has Rift Valley fever virus evolved with increasing severity in human populations in East Africa?

    PubMed

    Baba, Marycelin; Masiga, Daniel K; Sang, Rosemary; Villinger, Jandouwe

    2016-06-22

    Rift Valley fever (RVF) outbreaks have occurred across eastern Africa from 1912 to 2010 approximately every 4-15 years, most of which have not been accompanied by significant epidemics in human populations. However, human epidemics during RVF outbreaks in eastern Africa have involved 478 deaths in 1998, 1107 reported cases with 350 deaths from 2006 to 2007 and 1174 cases with 241 deaths in 2008. We review the history of RVF outbreaks in eastern Africa to identify the epidemiological factors that could have influenced its increasing severity in humans. Diverse ecological factors influence outbreak frequency, whereas virus evolution has a greater impact on its virulence in hosts. Several factors could have influenced the lack of information on RVF in humans during earlier outbreaks, but the explosive nature of human RVF epidemics in recent years mirrors the evolutionary trend of the virus. Comparisons between isolates from different outbreaks have revealed an accumulation of genetic mutations and genomic reassortments that have diversified RVF virus genomes over several decades. The threat to humans posed by the diversified RVF virus strains increases the potential public health and socioeconomic impacts of future outbreaks. Understanding the shifting RVF epidemiology as determined by its evolution is key to developing new strategies for outbreak mitigation and prevention of future human RVF casualties.

  18. The epigenetic lorax: gene–environment interactions in human health

    PubMed Central

    Latham, Keith E; Sapienza, Carmen; Engel, Nora

    2012-01-01

    Over the last decade, we have witnessed an explosion of information on genetic factors underlying common human diseases and disorders. This ‘human genomics’ information revolution has occurred as a backdrop to a rapid increase in the rates of many human disorders and diseases. For example, obesity, Type 2 diabetes, asthma, autism spectrum disorder and attention deficit hyperactivity disorder have increased at rates that cannot be due to changes in the genetic structure of the population, and are difficult to ascribe to changes in diagnostic criteria or ascertainment. A likely cause of the increased incidence of these disorders is increased exposure to environmental factors that modify gene function. Many environmental factors that have epidemiological association with common human disorders are likely to exert their effects through epigenetic alterations. This general mechanism of gene–environment interaction poses special challenges for individuals, educators, scientists and public policy makers in defining, monitoring and mitigating exposures. PMID:22920179

  19. Human mobility: Models and applications

    NASA Astrophysics Data System (ADS)

    Barbosa, Hugo; Barthelemy, Marc; Ghoshal, Gourab; James, Charlotte R.; Lenormand, Maxime; Louail, Thomas; Menezes, Ronaldo; Ramasco, José J.; Simini, Filippo; Tomasini, Marcello

    2018-03-01

    Recent years have witnessed an explosion of extensive geolocated datasets related to human movement, enabling scientists to quantitatively study individual and collective mobility patterns, and to generate models that can capture and reproduce the spatiotemporal structures and regularities in human trajectories. The study of human mobility is especially important for applications such as estimating migratory flows, traffic forecasting, urban planning, and epidemic modeling. In this survey, we review the approaches developed to reproduce various mobility patterns, with the main focus on recent developments. This review can be used both as an introduction to the fundamental modeling principles of human mobility, and as a collection of technical methods applicable to specific mobility-related problems. The review organizes the subject by differentiating between individual and population mobility and also between short-range and long-range mobility. Throughout the text the description of the theory is intertwined with real-world applications.

  20. Application of high explosion cratering data to planetary problems

    NASA Technical Reports Server (NTRS)

    Oberbeck, V. R.

    1977-01-01

    The present paper deals with the conditions of explosion or nuclear cratering required to simulate impact crater formation. Some planetary problems associated with three different aspects of crater formation are discussed, and solutions based on high-explosion data are proposed. Structures of impact craters and some selected explosion craters formed in layered media are examined and are related to the structure of lunar basins. The mode of ejection of material from impact craters is identified using explosion analogs. The ejection mode is shown to have important implications for the origin of material in crater and basin deposits. Equally important are the populations of secondary craters on lunar and planetary surfaces.

  1. Contraction type influences the human ability to use the available torque capacity of skeletal muscle during explosive efforts

    PubMed Central

    Tillin, Neale A.; Pain, Matthew T. G.; Folland, Jonathan P.

    2012-01-01

    The influence of contraction type on the human ability to use the torque capacity of skeletal muscle during explosive efforts has not been documented. Fourteen male participants completed explosive voluntary contractions of the knee extensors in four separate conditions: concentric (CON) and eccentric (ECC); and isometric at two knee angles (101°, ISO101 and 155°, ISO155). In each condition, torque was measured at 25 ms intervals up to 150 ms from torque onset, and then normalized to the maximum voluntary torque (MVT) specific to that joint angle and angular velocity. Explosive voluntary torque after 50 ms in each condition was also expressed as a percentage of torque generated after 50 ms during a supramaximal 300 Hz electrically evoked octet in the same condition. Explosive voluntary torque normalized to MVT was more than 60 per cent larger in CON than any other condition after the initial 25 ms. The percentage of evoked torque expressed after 50 ms of the explosive voluntary contractions was also greatest in CON (ANOVA; p < 0.001), suggesting higher concentric volitional activation. This was confirmed by greater agonist electromyography normalized to Mmax (recorded during the explosive voluntary contractions) in CON. These results provide novel evidence that the ability to use the muscle's torque capacity explosively is influenced by contraction type, with concentric contractions being more conducive to explosive performance due to a more effective neural strategy. PMID:22258636

  2. Population Explosion in the Yellow-Spined Bamboo Locust Ceracris kiangsu and Inferences for the Impact of Human Activity

    PubMed Central

    Fan, Zhou; Jiang, Guo-Fang; Liu, Yu-Xiang; He, Qi-Xin; Blanchard, Benjamin

    2014-01-01

    Geographic distance and geographical barriers likely play a considerable role in structuring genetic variation in species, although some migratory species may have less phylogeographic structure on a smaller spatial scale. Here, genetic diversity and the phylogenetic structure among geographical populations of the yellow-spined bamboo locust, Ceracris kiangsu, were examined with 16S rDNA and amplified fragment length polymorphisms (AFLPs). In this study, no conspicuous phylogeographical structure was discovered from either Maximum parsimony (MP) and Neighbor-joining (NJ) phylogenetic analyses. The effect of geographical isolation was not conspicuous on a large spatial scale.At smaller spatial scales local diversity of some populations within mountainous areas were detected using Nei's genetic distance and AMOVA. There is a high level of genetic diversity and a low genetic differentiation among populations in the C. kiangsu of South and Southeast China. Our analyses indicate that C. kiangsu is a monophyletic group. Our results also support the hypothesis that the C. kiangsu population is in a primary differentiation stage. Given the mismatch distribution, it is likely that a population expansion in C. kiangsu occurred about 0.242 Ma during the Quaternary interglaciation. Based on historical reports, we conjecture that human activities had significant impacts on the C. kiangsu gene flow. PMID:24603526

  3. Canine human scent identifications with post-blast debris collected from improvised explosive devices.

    PubMed

    Curran, Allison M; Prada, Paola A; Furton, Kenneth G

    2010-06-15

    In this study it is demonstrated that human odor collected from items recovered at a post-blast scene can be evaluated using human scent specific canine teams to locate and identify individuals who have been in contact with the improvised explosive device (IED) components and/or the delivery vehicle. The purpose of the experiments presented here was to document human scent survivability in both peroxide-based explosions as well as simulated roadside IEDs utilizing double-blind field trials. Human odor was collected from post-blast device and vehicle components. Human scent specific canine teams were then deployed at the blast scene and in locations removed from the blast scene to validate that human odor remains in sufficient quantities for reliable canine detection and identification. Human scent specific canines have shown the ability to identify individuals who have been in contact with IEDs using post-blast debris with an average success from site response of 82.2% verifying that this technology has great potential in criminal, investigative, and military applications. (c) 2010 Elsevier Ireland Ltd. All rights reserved.

  4. Modeling the Pre-Industrial Roots of Modern Super-Exponential Population Growth

    PubMed Central

    Stutz, Aaron Jonas

    2014-01-01

    To Malthus, rapid human population growth—so evident in 18th Century Europe—was obviously unsustainable. In his Essay on the Principle of Population, Malthus cogently argued that environmental and socioeconomic constraints on population rise were inevitable. Yet, he penned his essay on the eve of the global census size reaching one billion, as nearly two centuries of super-exponential increase were taking off. Introducing a novel extension of J. E. Cohen's hallmark coupled difference equation model of human population dynamics and carrying capacity, this article examines just how elastic population growth limits may be in response to demographic change. The revised model involves a simple formalization of how consumption costs influence carrying capacity elasticity over time. Recognizing that complex social resource-extraction networks support ongoing consumption-based investment in family formation and intergenerational resource transfers, it is important to consider how consumption has impacted the human environment and demography—especially as global population has become very large. Sensitivity analysis of the consumption-cost model's fit to historical population estimates, modern census data, and 21st Century demographic projections supports a critical conclusion. The recent population explosion was systemically determined by long-term, distinctly pre-industrial cultural evolution. It is suggested that modern globalizing transitions in technology, susceptibility to infectious disease, information flows and accumulation, and economic complexity were endogenous products of much earlier biocultural evolution of family formation's embeddedness in larger, hierarchically self-organizing cultural systems, which could potentially support high population elasticity of carrying capacity. Modern super-exponential population growth cannot be considered separately from long-term change in the multi-scalar political economy that connects family formation and intergenerational resource transfers to wider institutions and social networks. PMID:25141019

  5. Molecular mechanism-based model to enhance outcomes of dietary intervention studies for disease prevention

    PubMed Central

    Dey, Moul

    2014-01-01

    Advances in “omics”-based fields have produced an explosion of new information, fueling high expectations for improved public and individualized health. Unfortunately, there exists a widening gap between basic biochemistry and “omics”-based population research, with both disciplines failing to translate their full potential impact to human health applications. A paucity of comprehensive study systems is one of the many roadblocks faced by translational research today. This commentary will highlight the current status of such research, particularly emphasizing the role of nutrigenomics. PMID:25364700

  6. Selected Issues in DoD’s Radio Frequency Identification (RFID) Implementation

    DTIC Science & Technology

    2006-04-01

    Evaluation of human exposure to electromagnetic fields from devices operating in the frequency range 0 Hz to 10 GHz, used in Electronic...standard for human exposure to RF Signal, 3 kHz-300 GHz BS EN 50364 Limitation of human exposure to electromagnetic fields from devices operating in the...Management and DoD Explosives Safety Board, and DoDD 6055.9-STD, DoD Ammunition and Explosives Safety Standards. Exposure of people to electromagnetic

  7. [Paleobiology in the population of Herculaneum (79 A.D].

    PubMed

    Capasso, L; Capasso, L; Caramiello, S; D'Anastasio, R; Di Domenicantonio, L; Di Fabrizio, A; Di Nardo, F; La Verghetta, M

    2000-06-01

    The anthropologic examination of the human skeletal remains recovered on the ancient beach of Herculaneum provides a unique opportunity for gaining paleobiological data on a Roman population. The eruption caught the people on the ancient beach as they were trying to escape; the volcanic surges and pyroclastic flows had different effects on them depending upon where they were on the beach. Those caught in the open suffered immediate dehydratation, with cranial explosion and complete burning of bones, whereas those trapped in the boat sheds suffered slower dehydration. Histological analysis of the bone remains reveals an exposure to temperatures of 350-400 degrees C; the slower dehydratation of those in the sheds resulted in the preservation of some soft tissues, which are exceptional findings.

  8. Has Rift Valley fever virus evolved with increasing severity in human populations in East Africa?

    PubMed Central

    Baba, Marycelin; Masiga, Daniel K; Sang, Rosemary; Villinger, Jandouwe

    2016-01-01

    Rift Valley fever (RVF) outbreaks have occurred across eastern Africa from 1912 to 2010 approximately every 4–15 years, most of which have not been accompanied by significant epidemics in human populations. However, human epidemics during RVF outbreaks in eastern Africa have involved 478 deaths in 1998, 1107 reported cases with 350 deaths from 2006 to 2007 and 1174 cases with 241 deaths in 2008. We review the history of RVF outbreaks in eastern Africa to identify the epidemiological factors that could have influenced its increasing severity in humans. Diverse ecological factors influence outbreak frequency, whereas virus evolution has a greater impact on its virulence in hosts. Several factors could have influenced the lack of information on RVF in humans during earlier outbreaks, but the explosive nature of human RVF epidemics in recent years mirrors the evolutionary trend of the virus. Comparisons between isolates from different outbreaks have revealed an accumulation of genetic mutations and genomic reassortments that have diversified RVF virus genomes over several decades. The threat to humans posed by the diversified RVF virus strains increases the potential public health and socioeconomic impacts of future outbreaks. Understanding the shifting RVF epidemiology as determined by its evolution is key to developing new strategies for outbreak mitigation and prevention of future human RVF casualties. PMID:27329846

  9. Source spectral variation and yield estimation for small, near-source explosions

    NASA Astrophysics Data System (ADS)

    Yoo, S.; Mayeda, K. M.

    2012-12-01

    Significant S-wave generation is always observed from explosion sources which can lead to difficulty in discriminating explosions from natural earthquakes. While there are numerous S-wave generation mechanisms that are currently the topic of significant research, the mechanisms all remain controversial and appear to be dependent upon the near-source emplacement conditions of that particular explosion. To better understand the generation and partitioning of the P and S waves from explosion sources and to enhance the identification and discrimination capability of explosions, we investigate near-source explosion data sets from the 2008 New England Damage Experiment (NEDE), the Humble-Redwood (HR) series of explosions, and a Massachusetts quarry explosion experiment. We estimate source spectra and characteristic source parameters using moment tensor inversions, direct P and S waves multi-taper analysis, and improved coda spectral analysis using high quality waveform records from explosions from a variety of emplacement conditions (e.g., slow/fast burning explosive, fully tamped, partially tamped, single/ripple-fired, and below/above ground explosions). The results from direct and coda waves are compared to theoretical explosion source model predictions. These well-instrumented experiments provide us with excellent data from which to document the characteristic spectral shape, relative partitioning between P and S-waves, and amplitude/yield dependence as a function of HOB/DOB. The final goal of this study is to populate a comprehensive seismic source reference database for small yield explosions based on the results and to improve nuclear explosion monitoring capability.

  10. Efficient Moment-Based Inference of Admixture Parameters and Sources of Gene Flow

    PubMed Central

    Levin, Alex; Reich, David; Patterson, Nick; Berger, Bonnie

    2013-01-01

    The recent explosion in available genetic data has led to significant advances in understanding the demographic histories of and relationships among human populations. It is still a challenge, however, to infer reliable parameter values for complicated models involving many populations. Here, we present MixMapper, an efficient, interactive method for constructing phylogenetic trees including admixture events using single nucleotide polymorphism (SNP) genotype data. MixMapper implements a novel two-phase approach to admixture inference using moment statistics, first building an unadmixed scaffold tree and then adding admixed populations by solving systems of equations that express allele frequency divergences in terms of mixture parameters. Importantly, all features of the model, including topology, sources of gene flow, branch lengths, and mixture proportions, are optimized automatically from the data and include estimates of statistical uncertainty. MixMapper also uses a new method to express branch lengths in easily interpretable drift units. We apply MixMapper to recently published data for Human Genome Diversity Cell Line Panel individuals genotyped on a SNP array designed especially for use in population genetics studies, obtaining confident results for 30 populations, 20 of them admixed. Notably, we confirm a signal of ancient admixture in European populations—including previously undetected admixture in Sardinians and Basques—involving a proportion of 20–40% ancient northern Eurasian ancestry. PMID:23709261

  11. A possible outbreak of swine influenza, 1892.

    PubMed

    Morens, David M; Taubenberger, Jeffery K

    2014-02-01

    Influenza A viruses are globally enzootic in swine populations. Swine influenza has been recognised only since 1918, but an anecdotal report suggests that a swine-influenza epizootic might have occurred in England in 1892, at the same time as an explosive epidemic (or pandemic recurrence) of human influenza. This outbreak suggests that the ecobiological association between human and swine influenza could extend to before 1918. By contrast with the recent documentation of swine influenza, influenza in horses has been well documented for hundreds of years, and was often linked temporally and geographically to epidemics of human influenza. Both decreased contact between people and horses, and the concomitant increase in swine production over the past century, might have altered the character and dynamics of influenza host-switch events between people and domestic mammals. Copyright © 2014 Elsevier Ltd. All rights reserved.

  12. Combined Biological and Chemical Mechanisms for Degradation of Insensitive Munitions in the Presence of Alternate Explosives

    DTIC Science & Technology

    2017-06-21

    military facilities and firing ranges, may pose a risk to the environment10 and humans ’ health .13 As such, it may require a remediation plan for the...fire ranges. Nitroaromatic and nitramine compounds such as explosives are carcinogenic and mutagenic so they pose threat to human health and the...detonations. It is crucial to understand their fate and transport in subsurface environments as they can pose a significant hazard to humans and

  13. New roads toward North-South cooperation.

    PubMed

    Terpstra, E G

    1989-12-01

    A Netherlands Parliament member gives a European Perspective on population and development, problems in urban development, and methods of cooperation between industrialized and developing countries. On population and development, the relationship between population explosion and poverty, underdevelopment, environment, social infrastructure, and food shortages is pointed out. Most population growth in the years ahead will be in developing countries. Rampant population growth and burgeoning poverty strain the world's carrying capacity and environment, both in industrial and developing countries. Development policy and cooperation will fail in the absence of efforts to stem population growth. On this front, religious and political leaders have groundbreaking cooperative steps in supporting international family planning efforts through the global forum of Spiritual and Parliamentary Leaders on Human Survival. Economic development, environment, and population issues are inexorably tied together. The numerous problems faced by uncontrolled Third World urbanization are discussed with potential solutions for change. Incorporating women in the development process is strongly encouraged. The interdependent North-South relationship is discussed. All nations, the private sector, nongovernmental organizations, and women must cooperate to find solutions and effect positive change on a case-by-case basis.

  14. Matchmaker, Matchmaker, Make Me a Match: Migration of Populations via Marriages in the Past

    NASA Astrophysics Data System (ADS)

    Lee, Sang Hoon; Ffrancon, Robyn; Abrams, Daniel M.; Kim, Beom Jun; Porter, Mason A.

    2014-10-01

    The study of human mobility is both of fundamental importance and of great potential value. For example, it can be leveraged to facilitate efficient city planning and improve prevention strategies when faced with epidemics. The newfound wealth of rich sources of data—including banknote flows, mobile phone records, and transportation data—has led to an explosion of attempts to characterize modern human mobility. Unfortunately, the dearth of comparable historical data makes it much more difficult to study human mobility patterns from the past. In this paper, we present an analysis of long-term human migration, which is important for processes such as urbanization and the spread of ideas. We demonstrate that the data record from Korean family books (called "jokbo") can be used to estimate migration patterns via marriages from the past 750 years. We apply two generative models of long-term human mobility to quantify the relevance of geographical information to human marriage records in the data, and we find that the wide variety in the geographical distributions of the clans poses interesting challenges for the direct application of these models. Using the different geographical distributions of clans, we quantify the "ergodicity" of clans in terms of how widely and uniformly they have spread across Korea, and we compare these results to those obtained using surname data from the Czech Republic. To examine population flow in more detail, we also construct and examine a population-flow network between regions. Based on the correlation between ergodicity and migration in Korea, we identify two different types of migration patterns: diffusive and convective. We expect the analysis of diffusive versus convective effects in population flows to be widely applicable to the study of mobility and migration patterns across different cultures.

  15. Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants.

    PubMed

    Fu, Wenqing; O'Connor, Timothy D; Jun, Goo; Kang, Hyun Min; Abecasis, Goncalo; Leal, Suzanne M; Gabriel, Stacey; Rieder, Mark J; Altshuler, David; Shendure, Jay; Nickerson, Deborah A; Bamshad, Michael J; Akey, Joshua M

    2013-01-10

    Establishing the age of each mutation segregating in contemporary human populations is important to fully understand our evolutionary history and will help to facilitate the development of new approaches for disease-gene discovery. Large-scale surveys of human genetic variation have reported signatures of recent explosive population growth, notable for an excess of rare genetic variants, suggesting that many mutations arose recently. To more quantitatively assess the distribution of mutation ages, we resequenced 15,336 genes in 6,515 individuals of European American and African American ancestry and inferred the age of 1,146,401 autosomal single nucleotide variants (SNVs). We estimate that approximately 73% of all protein-coding SNVs and approximately 86% of SNVs predicted to be deleterious arose in the past 5,000-10,000 years. The average age of deleterious SNVs varied significantly across molecular pathways, and disease genes contained a significantly higher proportion of recently arisen deleterious SNVs than other genes. Furthermore, European Americans had an excess of deleterious variants in essential and Mendelian disease genes compared to African Americans, consistent with weaker purifying selection due to the Out-of-Africa dispersal. Our results better delimit the historical details of human protein-coding variation, show the profound effect of recent human history on the burden of deleterious SNVs segregating in contemporary populations, and provide important practical information that can be used to prioritize variants in disease-gene discovery.

  16. Automation in airport security X-ray screening of cabin baggage: Examining benefits and possible implementations of automated explosives detection.

    PubMed

    Hättenschwiler, Nicole; Sterchi, Yanik; Mendes, Marcia; Schwaninger, Adrian

    2018-10-01

    Bomb attacks on civil aviation make detecting improvised explosive devices and explosive material in passenger baggage a major concern. In the last few years, explosive detection systems for cabin baggage screening (EDSCB) have become available. Although used by a number of airports, most countries have not yet implemented these systems on a wide scale. We investigated the benefits of EDSCB with two different levels of automation currently being discussed by regulators and airport operators: automation as a diagnostic aid with an on-screen alarm resolution by the airport security officer (screener) or EDSCB with an automated decision by the machine. The two experiments reported here tested and compared both scenarios and a condition without automation as baseline. Participants were screeners at two international airports who differed in both years of work experience and familiarity with automation aids. Results showed that experienced screeners were good at detecting improvised explosive devices even without EDSCB. EDSCB increased only their detection of bare explosives. In contrast, screeners with less experience (tenure < 1 year) benefitted substantially from EDSCB in detecting both improvised explosive devices and bare explosives. A comparison of all three conditions showed that automated decision provided better human-machine detection performance than on-screen alarm resolution and no automation. This came at the cost of slightly higher false alarm rates on the human-machine system level, which would still be acceptable from an operational point of view. Results indicate that a wide-scale implementation of EDSCB would increase the detection of explosives in passenger bags and automated decision instead of automation as diagnostic aid with on screen alarm resolution should be considered. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

  17. Finding the first cosmic explosions. IV. 90–140 $$\\;{{M}_{\\odot }}$$ pair-stability supernovae

    DOE PAGES

    Smidt, Joseph; Whalen, Daniel J.; Chatzopoulos, E.; ...

    2015-05-19

    Population III stars that die as pair-instability supernovae are usually thought to fall in the mass range of 140 - 260 M ⊙. However, several lines of work have now shown that rotation can build up the He cores needed to encounter the pair instability at stellar masses as low as 90 M ⊙. Depending on the slope of the initial mass function of Population III stars, there could be 4 - 5 times as many stars from 90 - 140 M ⊙ in the primordial universe than in the usually accepted range. We present numerical simulations of the pair-instabilitymore » explosions of such stars performed with the MESA, FLASH and RAGE codes. We find that they will be visible to supernova factories such as Pan-STARRS and LSST in the optical out to z ~ 1-2 and JWST and the 30 m-class telescopes in the NIR out to z ~ 7-10. Such explosions will thus probe the stellar populations of the first galaxies and cosmic star formation rates in the era of cosmological reionization. These supernovae are also easily distinguished from more massive pair-instability explosions, underscoring the fact that there is far greater variety to the light curves of these events than previously understood.« less

  18. Chemical energy system for a borehole seismic source. [Final report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Engelke, R.; Hedges, R.O.

    1996-03-01

    We describe a detonation system that will be useful in the seismological examination of geological structures. The explosive component of this system is produced by the mixing of two liquids; these liquids are classified as non-explosive materials by the Department of Transportation. This detonation system could be employed in a borehole tool in which many explosions are made to occur at various points in the borehole. The explosive for each explosion would be mixed within the tool immediately prior to its being fired. Such an arrangement ensures that no humans are ever in proximity to explosives. Initiation of the explosivemore » mixture is achieved with an electrical slapper detonator whose specific parameters are described; this electrical initiation system does not contain any explosive. The complete electrical/mechanical/explosive system is shown to be able to perform correctly at temperatures {le}120{degrees}C and at depths in a water-filled borehole of {le} 4600 ft (i.e., at pressures of {le}2000 psig).« less

  19. Population Trends and the Implications for Education.

    ERIC Educational Resources Information Center

    Hauser, Philip M.

    There are three developments which have profoundly affected mans' values, attitudes, social institutions, and behaviorisms. These are the population explosion, the population implosion, and population differentiation. These three developments are interrelated and are affected by accelerating rates of technological and social change. By reason of…

  20. Recent human evolution has shaped geographical differences in susceptibility to disease

    PubMed Central

    2011-01-01

    Background Searching for associations between genetic variants and complex diseases has been a very active area of research for over two decades. More than 51,000 potential associations have been studied and published, a figure that keeps increasing, especially with the recent explosion of array-based Genome-Wide Association Studies. Even if the number of true associations described so far is high, many of the putative risk variants detected so far have failed to be consistently replicated and are widely considered false positives. Here, we focus on the world-wide patterns of replicability of published association studies. Results We report three main findings. First, contrary to previous results, genes associated to complex diseases present lower degrees of genetic differentiation among human populations than average genome-wide levels. Second, also contrary to previous results, the differences in replicability of disease associated-loci between Europeans and East Asians are highly correlated with genetic differentiation between these populations. Finally, highly replicated genes present increased levels of high-frequency derived alleles in European and Asian populations when compared to African populations. Conclusions Our findings highlight the heterogeneous nature of the genetic etiology of complex disease, confirm the importance of the recent evolutionary history of our species in current patterns of disease susceptibility and could cast doubts on the status as false positives of some associations that have failed to replicate across populations. PMID:21261943

  1. Detection of residues from explosive manipulation by near infrared hyperspectral imaging: a promising forensic tool.

    PubMed

    Fernández de la Ossa, Mª Ángeles; Amigo, José Manuel; García-Ruiz, Carmen

    2014-09-01

    In this study near infrared hyperspectral imaging (NIR-HSI) is used to provide a fast, non-contact, non-invasive and non-destructive method for the analysis of explosive residues on human handprints. Volunteers manipulated individually each of these explosives and after deposited their handprints on plastic sheets. For this purpose, classical explosives, potentially used as part of improvised explosive devices (IEDs) as ammonium nitrate, blackpowder, single- and double-base smokeless gunpowders and dynamite were studied. A partial-least squares discriminant analysis (PLS-DA) model was built to detect and classify the presence of explosive residues in handprints. High levels of sensitivity and specificity for the PLS-DA classification model created to identify ammonium nitrate, blackpowder, single- and double-base smokeless gunpowders and dynamite residues were obtained, allowing the development of a preliminary library and facilitating the direct and in situ detection of explosives by NIR-HSI. Consequently, this technique is showed as a promising forensic tool for the detection of explosive residues and other related samples. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  2. Ion spectrometric detection technologies for ultra-traces of explosives: a review.

    PubMed

    Mäkinen, Marko; Nousiainen, Marjaana; Sillanpää, Mika

    2011-01-01

    In recent years, explosive materials have been widely employed for various military applications and civilian conflicts; their use for hostile purposes has increased considerably. The detection of different kind of explosive agents has become crucially important for protection of human lives, infrastructures, and properties. Moreover, both the environmental aspects such as the risk of soil and water contamination and health risks related to the release of explosive particles need to be taken into account. For these reasons, there is a growing need to develop analyzing methods which are faster and more sensitive for detecting explosives. The detection techniques of the explosive materials should ideally serve fast real-time analysis in high accuracy and resolution from a minimal quantity of explosive without involving complicated sample preparation. The performance of the in-field analysis of extremely hazardous material has to be user-friendly and safe for operators. The two closely related ion spectrometric methods used in explosive analyses include mass spectrometry (MS) and ion mobility spectrometry (IMS). The four requirements-speed, selectivity, sensitivity, and sampling-are fulfilled with both of these methods. Copyright © 2011 Wiley Periodicals, Inc.

  3. Population and National Development--The Dilemma of Developing Countries. Occasional Essay Number 2.

    ERIC Educational Resources Information Center

    Sai, Fred T.

    This essay describes the relationship of population to the overall development process and is based on a special university lecture given at the London School of Hygiene in February, 1974. The contents include discussions of population trends, reasons for the population explosion, the structure of populations, development inequalities,…

  4. World Population: Toward the Next Century. Revised Edition.

    ERIC Educational Resources Information Center

    Murphy, Elaine M.

    This document consists of answers to questions on various aspects of world population. They are: What is the population of the world? How fast is the population of the world growing? When will the population of the world stop growing? Is the term "population explosion" accurate? Why did this sudden growth occur? Did people have more babies than…

  5. Suicide bombers form a new injury profile.

    PubMed

    Aharonson-Daniel, Limor; Klein, Yoram; Peleg, Kobi

    2006-12-01

    Recent explosions of suicide bombers introduced new and unique profiles of injury. Explosives frequently included small metal parts, increasing severity of injuries, challenging both physicians and healthcare systems. Timely detonation in crowded and confined spaces further increased explosion effect. Israel National Trauma Registry data on hospitalized terror casualties between October 1, 2000 and December 31, 2004 were analyzed. A total of 1155 patients injured by explosion were studied. Nearly 30% suffered severe to critical injuries (ISS > or = 16); severe injuries (AIS > or = 3) were more prevalent than in other trauma. Triage has changed as metal parts contained in bombs penetrate the human body with great force and may result in tiny entry wounds easily concealed by hair, clothes etc. A total of 36.6% had a computed tomography (CT), 26.8% had ultrasound scanning, and 53.2% had an x-ray in the emergency department. From the emergency department, 28.3% went directly to the operating room, 10.1% to the intensive care unit, and 58.4% directly to the ward. Injuries were mostly internal, open wounds, and burns, with an excess of injuries to nerves and to blood vessels compared with other trauma mechanisms. A high rate of surgical procedures was recorded, including thoracotomies, laparotomies, craniotomies, and vascular surgery. In certain cases, there were simultaneous multiple injuries that required competing forms of treatment, such as burns and blast lung. Bombs containing metal fragments detonated by suicide bombers in crowded locations change patterns and severity of injury in a civil population. Specific injuries will require tailored approaches, an open mind, and close collaboration and cooperation between trauma surgeons to share experience, opinions, and ideas. Findings presented have implications for triage, diagnosis, treatment, hospital organization, and the definition of surge capacity.

  6. Earth Satellite Population Instability: Underscoring the Need for Debris Mitigation

    NASA Technical Reports Server (NTRS)

    Liou, Jer-chyi; Johnson, N. L.

    2006-01-01

    A recent study by NASA indicates that the implementation of international orbital debris mitigation measures alone will not prevent a significant increase in the artificial Earth satellite population, beginning in the second half of this century. Whereas the focus of the aerospace community for the past 25 years has been on the curtailment of the generation of long-lived orbital debris, active remediation of the current orbital debris population should now be reconsidered to help preserve near-Earth space for future generations. In particular, we show in this paper that even if launch operations were to cease today, the population of space debris would continue to grow. Further, proposed remediation techniques do not appear to offer a viable solution. We therefore recommend that, while the aerospace community maintains the current debris-limiting mission regulations and postmission disposal procedures, future emphasis should be placed on finding new remediation technologies for solving this growing problem. Since the launch of Sputnik 1, space activities have created an orbital debris environment that poses increasing impact risks to existing space systems, including human space flight and robotic missions (1, 2). Currently, more than 9,000 Earth orbiting man-made objects (including many breakup fragments), with a combined mass exceeding 5 million kilograms, are tracked by the US Space Surveillance Network and maintained in the US satellite catalog (3-5). Three accidental collisions between cataloged satellites during the period from late 1991 to early 2005 have already been documented (6), although fortunately none resulted in the creation of large, trackable debris clouds. Several studies conducted during 1991-2001 demonstrated, with assumed future launch rates, the unintended growth potential of the Earth satellite population, resulting from random, accidental collisions among resident space objects (7-13). In some low Earth orbit (LEO) altitude regimes where the number density of satellites is above a critical spatial density, the production rate of new satellites (i.e., debris) due to collisions exceeds the loss of objects due to orbital decay. NASA s evolutionary satellite population model LEGEND (LEO-to-GEO Environment Debris model), developed by the Orbital Debris Program Office at the NASA Lyndon B. Johnson Space Center, is a high fidelity three-dimensional physical model that is capable of simulating the historical satellite environment, as well as the evolution of future debris populations (14, 15). The subject study assumed no rocket bodies and spacecraft were launched after December 2004, and no future disposal maneuvers were allowed for existing spacecraft, few of which currently have such a capability. The rate of satellite explosions would naturally decrease to zero within a few decades as the current satellite population ages. The LEGEND future projection adopts a Monte Carlo approach to simulate future on-orbit explosions and collisions. Within a given projection time step, once the explosion probability is estimated for an intact object, a random number is drawn and compared with the probability to determine if an explosion would occur. A similar procedure is applied to collisions for each pair of target and projectile involved within the same time step. Due to the nature of the Monte Carlo process, multiple projection runs must be performed and analyzed before one can draw reliable and meaningful conclusions from the outcome. A total of fifty, 200-year future projection Monte Carlo simulations were executed and evaluated (16).

  7. Hot-spot contributions in shocked high explosives from mesoscale ignition models

    NASA Astrophysics Data System (ADS)

    Levesque, G.; Vitello, P.; Howard, W. M.

    2013-06-01

    High explosive performance and sensitivity is strongly related to the mesoscale defect densities. Bracketing the population of mesoscale hot spots that are active in the shocked ignition of explosives is important for the development of predictive reactive flow models. By coupling a multiphysics-capable hydrodynamics code (ale3d) with a chemical kinetics solver (cheetah), we can parametrically analyze different pore sizes undergoing collapse in high pressure shock conditions with evolving physical parameter fields. Implementing first-principles based decomposition kinetics, burning hot spots are monitored, and the regimes of pore sizes that contribute significantly to burnt mass faction and those that survive thermal conduction on the time scales of ignition are elucidated. Comparisons are drawn between the thermal explosion theory and the multiphysics models for the determination of nominal pore sizes that burn significantly during ignition for the explosive 1,3,5-triamino-2,4,6-trinitrobenzene.

  8. Explosive cell lysis as a mechanism for the biogenesis of bacterial membrane vesicles and biofilms

    PubMed Central

    Turnbull, Lynne; Toyofuku, Masanori; Hynen, Amelia L.; Kurosawa, Masaharu; Pessi, Gabriella; Petty, Nicola K.; Osvath, Sarah R.; Cárcamo-Oyarce, Gerardo; Gloag, Erin S.; Shimoni, Raz; Omasits, Ulrich; Ito, Satoshi; Yap, Xinhui; Monahan, Leigh G.; Cavaliere, Rosalia; Ahrens, Christian H.; Charles, Ian G.; Nomura, Nobuhiko; Eberl, Leo; Whitchurch, Cynthia B.

    2016-01-01

    Many bacteria produce extracellular and surface-associated components such as membrane vesicles (MVs), extracellular DNA and moonlighting cytosolic proteins for which the biogenesis and export pathways are not fully understood. Here we show that the explosive cell lysis of a sub-population of cells accounts for the liberation of cytosolic content in Pseudomonas aeruginosa biofilms. Super-resolution microscopy reveals that explosive cell lysis also produces shattered membrane fragments that rapidly form MVs. A prophage endolysin encoded within the R- and F-pyocin gene cluster is essential for explosive cell lysis. Endolysin-deficient mutants are defective in MV production and biofilm development, consistent with a crucial role in the biogenesis of MVs and liberation of extracellular DNA and other biofilm matrix components. Our findings reveal that explosive cell lysis, mediated through the activity of a cryptic prophage endolysin, acts as a mechanism for the production of bacterial MVs. PMID:27075392

  9. Mexico City's Petroleos Mexicanos explosion: disaster management and air medical transport.

    PubMed

    Urquieta, Emmanuel; Varon, Joseph

    2014-01-01

    Mexico City is the largest metropolitan area in the Americas and 1 of the largest in the world; its geographic location and uncontrolled population and industrial growth make this metropolis prone to natural and human-made disasters. Mass casualty disaster responses in Mexico City tend to have complications from multiple logistical and operational challenges. This article focuses on the experiences and lessons learned from an explosion that occurred in a government building in Mexico City and the current status of mass casualty disaster risks and response strategies in Mexico City as well as air medical evacuation, which is a critical component and was shown to be extremely useful in the evacuation of 15 critically ill and polytraumatized patients (Injury Severity Score > 15). Several components of the public and privately owned emergency medical services and health care systems among Mexico City pose serious logistical and operational complications, which finally will be addressed by a joint emergency preparedness council to unify criteria in communications, triage, and incident/disaster command post establishment. Copyright © 2014 Air Medical Journal Associates. Published by Elsevier Inc. All rights reserved.

  10. Low-energy Population III supernovae and the origin of extremely metal-poor stars

    NASA Astrophysics Data System (ADS)

    Chen, Ke-Jung; Heger, Alexander; Whalen, Daniel J.; Moriya, Takashi J.; Bromm, Volker; Woosley, S. E.

    2017-06-01

    Some ancient, dim, metal-poor stars may have formed in the ashes of the first supernovae (SNe). If their chemical abundances can be reconciled with the elemental yields of specific Population III (Pop III) explosions, they could reveal the properties of primordial stars. But multidimensional simulations of such explosions are required to predict their yields because dynamical instabilities can dredge material up from deep in the ejecta that would otherwise be predicted to fall back on to the central remnant and be lost in one-dimensional (1D) models. We have performed two-dimensional (2D) numerical simulations of two low-energy Pop III SNe, a 12.4 M⊙ explosion and a 60 M⊙ explosion, and find that they produce elemental yields that are a good fit to those measured in the most iron-poor star discovered to date, SMSS J031300.36-670839.3 (J031300). Fallback on to the compact remnant in these weak explosions accounts for the lack of measurable iron in J031300 and its low iron-group abundances in general. Our 2D explosions produce higher abundances of heavy elements (atomic number Z > 20) than their 1D counterparts due to dredge-up by fluid instabilities. Since almost no 56Ni is ejected by these weak SNe, their low luminosities will prevent their detection in the near-infrared with the James Webb Space Telescope and future 30-m telescopes on the ground. The only evidence that they ever occurred will be in the fossil abundance record.

  11. The Pacific tsunami warning system

    USGS Publications Warehouse

    Pararas-Carayannis, G.

    1986-01-01

    The impact of tsunamis on human societies can be traced back in written history to 480 BC, when the Minoan civilization in the Eastern Mediterranean was wiped out by great tsunami waves generated by the volcanic explosion of the island of Santorin. In the Pacific Ocean where the majority of these waves have been generated, the historical record, although brief, shows tremendous destruction. In Japan which has one of the most populated coastal regions in the world and a long history of earthquake activity, tsunamis have destroyed entire coastal communities. There is also history of tsunami destruction in Alaska, in Hawaiian Islands, and in South America. 

  12. [The role of the biological damaging factor in the explosive injury].

    PubMed

    Popov, V L; Kadochnikov, D S; Minaeva, P V

    2015-01-01

    This article describes the specific features of the action of the biological damaging factors on the human organism associated with the explosive injury. Both the direct action of the damaging agents contained in the biological weapons and their secondary effects in the form of systemic and local infectious complications of the inflicted wounds are considered. The criteria for the evaluation of the degree of harm to the health of the victims of explosion attributable to the action of the biological damaging factor are proposed.

  13. 40 CFR 264.56 - Emergency procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Contingency Plan and Emergency Procedures § 264.56 Emergency procedures. (a) Whenever there is an imminent or... designated response roles if their help is needed. (b) Whenever there is a release, fire, or explosion, the... human health or the environment that may result from the release, fire, or explosion. This assessment...

  14. 40 CFR 264.56 - Emergency procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Contingency Plan and Emergency Procedures § 264.56 Emergency procedures. (a) Whenever there is an imminent or... designated response roles if their help is needed. (b) Whenever there is a release, fire, or explosion, the... human health or the environment that may result from the release, fire, or explosion. This assessment...

  15. 40 CFR 264.56 - Emergency procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Contingency Plan and Emergency Procedures § 264.56 Emergency procedures. (a) Whenever there is an imminent or... designated response roles if their help is needed. (b) Whenever there is a release, fire, or explosion, the... human health or the environment that may result from the release, fire, or explosion. This assessment...

  16. 40 CFR 264.56 - Emergency procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Contingency Plan and Emergency Procedures § 264.56 Emergency procedures. (a) Whenever there is an imminent or... designated response roles if their help is needed. (b) Whenever there is a release, fire, or explosion, the... human health or the environment that may result from the release, fire, or explosion. This assessment...

  17. Population Explosion in Africa: Further Implications.

    ERIC Educational Resources Information Center

    Hidore, John J.

    1978-01-01

    Explains that population growth in Africa has caused a deterioration of vegetation and soil resources. This deterioration has resulted from overgrazing, too frequent and too extensive burning of the vegetation, and overcultivation. (Author/AV)

  18. Phylogeographic Reconstructions of a Rift Valley Fever Virus Strain Reveals Transboundary Animal Movements from Eastern Continental Africa to the Union of the Comoros.

    PubMed

    Maquart, M; Pascalis, H; Abdouroihamane, S; Roger, M; Abdourahime, F; Cardinale, E; Cêtre-Sossah, C

    2016-04-01

    Major explosive outbreaks of Rift Valley fever (RVF), an arthropod borne zoonotic disease, occur in humans and animals with significant mortality and economic impact across continental Africa and the Indian Ocean region (Madagascar, the Comoros archipelago). Recently, sporadic human cases have been reported in Mayotte and Grande Comore, two islands belonging to the Comoros archipelago. To identify the hypothetical source of virus introduction in an inter-epidemic or a post-epidemic period, a longitudinal survey of livestock was set up in Comorian ruminant populations, known to be susceptible hosts. The phylogeographic genomic analysis has shown that RVF virus (RVFV) detected in a zebu collected in Anjouan in August 2011 seems to be related to the last known epidemic of RVF which occurred in East Africa and Madagascar (2007-2009). This result highlights the fact that RVFV is maintained within local livestock populations and transboundary animal movements from eastern continental Africa to Indian Ocean islands likely result in RVFV crossover. © 2014 Blackwell Verlag GmbH.

  19. Understanding Laterally Varying Path Effects on P/S Ratios and their Effectiveness for Event Discrimination at Local Distances

    NASA Astrophysics Data System (ADS)

    Pyle, M. L.; Walter, W. R.

    2017-12-01

    Discrimination between underground explosions and naturally occurring earthquakes is an important endeavor for global security and test-ban treaty monitoring, and ratios of seismic P to S-wave amplitudes at regional distances have proven to be an effective discriminant. The use of the P/S ratio is rooted in the idea that explosive sources should theoretically only generate compressional energy. While, in practice, shear energy is observed from explosions, generally when corrections are made for magnitude and distance, P/S ratios from explosions are higher than those from surrounding earthquakes. At local distances (< 200 km) that might be needed to detect smaller events, however, this discriminant becomes less reliable. While ratios at some stations still show separation between earthquake and explosion populations, at other stations the populations are indistinguishable. There is no clear distance or azimuthal trend for which stations show discriminating abilities and which do not. A number of factors may play a role in differences we see between regional and local discrimination, including source effects such as depth and radiation pattern, and path effects such as laterally varying attenuation and focusing/defocusing from layers and scattering. We use data from the Source Physics Experiment (SPE) to investigate some of these effects. SPE is a series of chemical explosions at the Nevada National Security Site (NNSS) designed to improve our understanding and modeling capabilities of shear waves generated by explosions. Phase I consisted of 5 explosions in granite and Phase II will move to a contrasting dry alluvium geology. We apply a high-resolution 2D attenuation model to events near the NNSS to examine what effect path plays in local P/S ratios, and how well an earthquake-derived model can account for shallower explosion paths. The model incorporates both intrinsic attenuation and scattering effects and extends to 16 Hz, allowing us to make lateral path corrections and consider high-frequency ratios. Preliminary work suggests that while 2D path corrections modestly improve earthquake amplitude predictions, explosion amplitudes are not well matched, and so P/S ratios do not necessarily improve. Further work is needed to better understand the uses and limitation of 2D path corrections for local P/S ratios.

  20. The New Population Debate: Two Views on Population Growth and Economic Development. Population Trends and Public Policy, Number 7.

    ERIC Educational Resources Information Center

    King, Timothy; Kelley, Allen C.

    Articles representing two views on the issue of rapid population growth and economic development are presented. Although the authors present different perspectives, they agree on many of the fundamentals. For example, both reject alarmism about impending "population explosions" and the use of population as a scapegoat for all Third World…

  1. Nucleosynthesis in Primordial Hypernovae

    NASA Astrophysics Data System (ADS)

    Grimmett, J. J.; Heger, Alexander; Karakas, Amanda I.; Müller, Bernhard

    2018-06-01

    We investigate the relationship between explosion energy and nucleosynthesis in Population III supernovae and provide nucleosynthetic results for the explosions of stars with progenitor masses of 15 M⊙, 20 M⊙, 30 M⊙, 40 M⊙, 60 M⊙, and 80 M⊙, and explosion energies between approximately 1050 erg and 1053 erg. We find that the typical abundance pattern observed in metal-poor stars are best matched by supernovae with progenitor mass in the range 15 M⊙ - 30 M⊙, and explosion energy of ˜(5 - 10) × 1051 erg. In these models, a reverse shock caused by jumps in density between shells of different composition serves to decrease synthesis of chromium and manganese, which is favourable to matching the observed abundances in metal-poor stars. Spherically symmetric explosions of our models with progenitor mass ≥40 M⊙ do not provide yields that are compatible with the iron-peak abundances that are typically observed in metal-poor stars, however, by approximating the yields that we might expect from these models in highly aspherical explosions, we find indications that explosions of stars 40 M⊙ - 80 M⊙ with bipolar jets may be good candidates for the enrichment sources of metal-poor stars with enhanced carbon abundances.

  2. VCGDB: a dynamic genome database of the Chinese population

    PubMed Central

    2014-01-01

    Background The data released by the 1000 Genomes Project contain an increasing number of genome sequences from different nations and populations with a large number of genetic variations. As a result, the focus of human genome studies is changing from single and static to complex and dynamic. The currently available human reference genome (GRCh37) is based on sequencing data from 13 anonymous Caucasian volunteers, which might limit the scope of genomics, transcriptomics, epigenetics, and genome wide association studies. Description We used the massive amount of sequencing data published by the 1000 Genomes Project Consortium to construct the Virtual Chinese Genome Database (VCGDB), a dynamic genome database of the Chinese population based on the whole genome sequencing data of 194 individuals. VCGDB provides dynamic genomic information, which contains 35 million single nucleotide variations (SNVs), 0.5 million insertions/deletions (indels), and 29 million rare variations, together with genomic annotation information. VCGDB also provides a highly interactive user-friendly virtual Chinese genome browser (VCGBrowser) with functions like seamless zooming and real-time searching. In addition, we have established three population-specific consensus Chinese reference genomes that are compatible with mainstream alignment software. Conclusions VCGDB offers a feasible strategy for processing big data to keep pace with the biological data explosion by providing a robust resource for genomics studies; in particular, studies aimed at finding regions of the genome associated with diseases. PMID:24708222

  3. Detection and mapping of trace explosives on surfaces under ambient conditions using multiphoton electron extraction spectroscopy (MEES).

    PubMed

    Tang, Shisong; Vinerot, Nataly; Fisher, Danny; Bulatov, Valery; Yavetz-Chen, Yehuda; Schechter, Israel

    2016-08-01

    Multiphoton electron extraction spectroscopy (MEES) is an analytical method in which UV laser pulses are utilized for extracting electrons from solid surfaces in multiphoton processes under ambient conditions. Counting the emitted electrons as a function of laser wavelength results in detailed spectral features, which can be used for material identification. The method has been applied to detection of trace explosives on a variety of surfaces. Detection was possible on dusty swabs spiked with explosives and also in the standard dry-transfer contamination procedure. Plastic explosives could also be detected. The analytical limits of detection (LODs) are in the sub pmole range, which indicates that MEES is one of the most sensitive detection methods for solid surface under ambient conditions. Scanning the surface with the laser allows for its imaging, such that explosives (as well as other materials) can be located. The imaging mode is also useful in forensic applications, such as detection of explosives in human fingerprints. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. Acute occupational poisoning by octogen: first case report.

    PubMed

    Testud, François; Descotes, Jacques; Le Meur, Brigitte

    2006-01-01

    Octogen (HMX) is a polynitramine explosive closely related to hexogen, a known occupational toxin in military munitions plants. No acute human poisoning with octogen has ever been reported. A 28-year-old man with no history of epilepsy was admitted to the Emergency Department for seizures that had developed during the night after a full working day when he manually sieved large amounts of dry octogen. On admission, the clinical examination was normal and all other examinations could not substantiate the development of essential or secondary epilepsy. Elevated octogen concentrations were measured in his plasma, which confirmed occupational exposure to the explosive. The rarity of acute human poisonings by octogen is due to the infrequent use of this explosive and, more importantly, its very low oral bioavailability. However, acute poisoning can occur, but should be easily avoided by implementing adequate preventive measures.

  5. Reproductive Health: An Introduction to IUCD in India

    ERIC Educational Resources Information Center

    Tripathi, Vrijesh; Nandan, Deoki

    2006-01-01

    The world has a population of 6 billion. India alone has a population of 1 billion. This is despite the fact that India was the first country in the world to have a population policy. It is important to understand the factors that led to this population explosion and the complex links between population growth rates and levels of development.…

  6. Historical Population Estimates For Several Fish Species At Offshore Oil and Gas Structures in the US Gulf of Mexico

    NASA Astrophysics Data System (ADS)

    Gitschlag, G.

    2016-02-01

    Population estimates were calculated for four fish species occurring at offshore oil and gas structures in water depths of 14-32 m off the Louisiana and upper Texas coasts in the US Gulf of Mexico. From 1993-1999 sampling was conducted at eight offshore platforms in conjunction with explosive salvage of the structures. To estimate fish population size prior to detonation of explosives, a fish mark-recapture study was conducted. Fish were captured on rod and reel using assorted hook sizes. Traps were occasionally used to supplement catches. Fish were tagged below the dorsal fin with plastic t-bar tags using tagging guns. Only fish that were alive and in good condition were released. Recapture sampling was conducted after explosives were detonated during salvage operations. Personnel operating from inflatable boats used dip nets to collect all dead fish that floated to the surface. Divers collected representative samples of dead fish that sank to the sea floor. Data provided estimates for red snapper (Lutjanus campechanus), Atlantic spadefish (Chaetodipterus faber), gray triggerfish (Balistes capriscus), and blue runner (Caranx crysos) at one or more of the eight platforms studied. At seven platforms, population size for red snapper was calculated at 503-1,943 with a 95% CI of 478. Abundance estimates for Atlantic spadefish at three platforms ranged from 1,432-1,782 with a 95% CI of 473. At three platforms, population size of gray triggerfish was 63-129 with a 95% CI of 82. Blue runner abundance at one platform was 558. Unlike the other three species which occur close to the platforms, blue runner range widely and recapture of this species was dependent on fish schools being in close proximity to the platform at the time explosives were detonated. Tag recapture was as high as 73% for red snapper at one structure studied.

  7. Population Growth: Crisis and Challenge.

    ERIC Educational Resources Information Center

    Beaton, John R., Ed.; Doberenz, Alexander R., Ed.

    The proceedings of this first annual symposium on population growth considers the consequences of this growth, along with possible means of regulation. Topics of speeches include: Population Outlook in Asia (Irene Taeuber); Malnutrition is a Problem of Ecology (Paul Gyorgy); The Leisure Explosion (E. H. Storey); Effects of Pollution on Population…

  8. Population growth and economic growth.

    PubMed

    Narayana, D L

    1984-01-01

    This discussion of the issues relating to the problem posed by population explosion in the developing countries and economic growth in the contemporary world covers the following: predictions of economic and social trends; the Malthusian theory of population; the classical or stationary theory of population; the medical triage model; ecological disaster; the Global 2000 study; the limits to growth; critiques of the Limits to Growth model; nonrenewable resources; food and agriculture; population explosion and stabilization; space and ocean colonization; and the limits perspective. The Limits to Growth model, a general equilibrium anti-growth model, is the gloomiest economic model ever constructed. None of the doomsday models, the Malthusian theory, the classical stationary state, the neo-Malthusian medical triage model, the Global 2000 study, are so far reaching in their consequences. The course of events that followed the publication of the "Limits to Growth" in 1972 in the form of 2 oil shocks, food shock, pollution shock, and price shock seemed to bear out formally the gloomy predictions of the thesis with a remarkable speed. The 12 years of economic experience and the knowledge of resource trends postulate that even if the economic pressures visualized by the model are at work they are neither far reaching nor so drastic. Appropriate action can solve them. There are several limitations to the Limits to Growth model. The central theme of the model, which is overshoot and collapse, is unlikely to be the course of events. The model is too aggregative to be realistic. It exaggerates the ecological disaster arising out of the exponential growth of population and industry. The gross underestimation of renewable resources is a basic flaw of the model. The most critical weakness of the model is its gross underestimation of the historical trend of technological progress and the technological possiblities within industry and agriculture. The model does correctly emphasize the exponential growth of population as the source of several complications for economic growth and human welfare. Stabilization of population by reducing fertility is conducive for improving the quality of population and also advances the longterm management of the population growth and work force utilization. The perspective of longterm economic management involves populatio n planning, control of environmental pollution, conservation of scarce resources, exploration of resources, realization of technological possibilities in agriculture and industry and in farm and factory, and achievement of economic growth and its equitable distribution.

  9. Human Health and Ecological Risk Assessment for the Operation of the Explosives Waste Treatment Facility at Site 300 of the Lawrence Livermore National Laboratory Volume 1: Report of Results

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gallegos, G; Daniels, J; Wegrecki, A

    2006-04-24

    This document contains the human health and ecological risk assessment for the Resource Recovery and Conservation Act (RCRA) permit renewal for the Explosives Waste Treatment Facility (EWTF). Volume 1 is the text of the risk assessment, and Volume 2 (provided on a compact disc) is the supporting modeling data. The EWTF is operated by the Lawrence Livermore National Laboratory (LLNL) at Site 300, which is located in the foothills between the cities of Livermore and Tracy, approximately 17 miles east of Livermore and 8 miles southwest of Tracy. Figure 1 is a map of the San Francisco Bay Area, showingmore » the location of Site 300 and other points of reference. One of the principal activities of Site 300 is to test what are known as ''high explosives'' for nuclear weapons. These are the highly energetic materials that provide the force to drive fissionable material to criticality. LLNL scientists develop and test the explosives and the integrated non-nuclear components in support of the United States nuclear stockpile stewardship program as well as in support of conventional weapons and the aircraft, mining, oil exploration, and construction industries. Many Site 300 facilities are used in support of high explosives research. Some facilities are used in the chemical formulation of explosives; others are locations where explosive charges are mechanically pressed; others are locations where the materials are inspected radiographically for such defects as cracks and voids. Finally, some facilities are locations where the machined charges are assembled before they are sent to the on-site test firing facilities, and additional facilities are locations where materials are stored. Wastes generated from high-explosives research are treated by open burning (OB) and open detonation (OD). OB and OD treatments are necessary because they are the safest methods for treating explosives wastes generated at these facilities, and they eliminate the requirement for further handling and transportation that would be required if the wastes were treated off site.« less

  10. Human Health and Ecological Risk Assessment for the Operation of the Explosives Waste Treatment Facility at Site 300 of the Lawrence Livermore National Laboratory

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gallegos, G; Daniels, J; Wegrecki, A

    2007-10-01

    This document contains the human health and ecological risk assessment for the Resource Recovery and Conservation Act (RCRA) permit renewal for the Explosives Waste Treatment Facility (EWTF). Volume 1 is the text of the risk assessment, and Volume 2 (provided on a compact disc) is the supporting modeling data. The EWTF is operated by the Lawrence Livermore National Laboratory (LLNL) at Site 300, which is located in the foothills between the cities of Livermore and Tracy, approximately 17 miles east of Livermore and 8 miles southwest of Tracy. Figure 1 is a map of the San Francisco Bay Area, showingmore » the location of Site 300 and other points of reference. One of the principal activities of Site 300 is to test what are known as 'high explosives' for nuclear weapons. These are the highly energetic materials that provide the force to drive fissionable material to criticality. LLNL scientists develop and test the explosives and the integrated non-nuclear components in support of the United States nuclear stockpile stewardship program as well as in support of conventional weapons and the aircraft, mining, oil exploration, and construction industries. Many Site 300 facilities are used in support of high explosives research. Some facilities are used in the chemical formulation of explosives; others are locations where explosive charges are mechanically pressed; others are locations where the materials are inspected radiographically for such defects as cracks and voids. Finally, some facilities are locations where the machined charges are assembled before they are sent to the onsite test firing facilities, and additional facilities are locations where materials are stored. Wastes generated from high-explosives research are treated by open burning (OB) and open detonation (OD). OB and OD treatments are necessary because they are the safest methods for treating explosives wastes generated at these facilities, and they eliminate the requirement for further handling and transportation that would be required if the wastes were treated off site.« less

  11. Eye-safe UV Raman spectroscopy for remote detection of explosives and their precursors in fingerprint concentration

    NASA Astrophysics Data System (ADS)

    Almaviva, S.; Angelini, F.; Chirico, R.; Palucci, A.; Nuvoli, M.; Schnuerer, F.; Schweikert, W.; Romolo, F. S.

    2014-10-01

    We report the results of Raman investigation performed at stand-off distance between 6-10 m with a new apparatus, capable to detect traces of explosives with surface concentrations similar to those of a single fingerprint. The device was developed as part of the RADEX prototype (RAman Detection of EXplosives) and is capable of detecting the Raman signal with a single laser shot of few ns (10-9 s) in the UV range (wavelength 266 nm), in conditions of safety for the human eye. This is because the maximum permissible exposure (MPE) for the human eye is established to be 3 mJ/cm2 in this wavelength region and pulse duration. Samples of explosives (PETN, TNT, Urea Nitrate, Ammonium Nitrate) were prepared starting from solutions deposited on samples of common fabrics or clothing materials such as blue jeans, leather, polyester or polyamide. The deposition process takes place via a piezoelectric-controlled plotter device, capable of producing drops of welldefined volume, down to nanoliters, on a surface of several cm2, in order to carefully control the amount of explosive released to the tissue and thus simulate a slight stain on a garment of a potential terrorist. Depending on the type of explosive sampled, the detected density ranges from 0.1 to 1 mg/cm2 and is comparable to the density measured in a spot on a dress or a bag due to the contact with hands contaminated with explosives, as it could happen in the preparation of an improvised explosive device (IED) by a terrorist. To our knowledge the developed device is at the highest detection limits nowadays achievable in the field of eyesafe, stand-off Raman instruments. The signals obtained show some vibrational bands of the Raman spectra of our samples with high signal-to-noise ratio (SNR), allowing us to identify with high sensitivity (high number of True Positives) and selectivity (low number of False Positives) the explosives, so that the instrument could represent the basis for an automated and remote monitoring device.

  12. Population: fiction and fact.

    PubMed

    1979-09-01

    This article was written to refute some common misunderstandings regarding worldwide population levels and worldwide nutrition levels. The world food supply is able to keep pace with high population growth levels. Worl food production currently meets world need; the problem is a distribution system which allocates food only to those who can pay rather than to those who need it. In many developing countries, the best agricultural lands are reserved for commercial crops rather than for subsistence crops. The U.S. food aid program does not help the most needy nations generally. The rate of world population growth is already slowing down. The desire for large families in developing countries is very often a realistic reaction to the prevailing economic system. Family planning programs will succeed. They will succeed even better in countries where general development planning is undertaken concurrently with family planning. Environmental problems are attributable to the consumption explosion in the rich countries rather than to the population explosion in the poor countries.

  13. Programs for calculating the explosion resistance of buildings and structures

    NASA Astrophysics Data System (ADS)

    Shevchenko, Nikita; Manucharyan, Rachik; Gravit, Marina; Geraskin, Yuriy

    2017-10-01

    Trends in the development of the oil and gas processing industry and facilities using liquefied hydrocarbon gases in the technological processes lead to an increase in the number of emergency situations and as a result to the increase of the damage and environmental degradation. A gasified housing stock is a special group of explosive objects. The accident in such disasters lead to hundreds of human victims. The main danger of explosive effects on objects can lead to a large-scale destruction connected with an “internal explosion”. It results in the release of combustible substances (gas, oil, etc.) into enclosed or semi-enclosed rooms (modules) with the ignition (in explosion mode of deflagration or detonation) of air gas mixtures (AGM).

  14. Explosive electromagnetic radiation by the relaxation of a multimode magnon system.

    PubMed

    Vasyuchka, V I; Serga, A A; Sandweg, C W; Slobodianiuk, D V; Melkov, G A; Hillebrands, B

    2013-11-01

    Microwave emission from a parametrically pumped ferrimagnetic film of yttrium iron garnet was studied versus the magnon density evolution, which was detected by Brillouin light scattering spectroscopy. It has been found that the shutdown of external microwave pumping leads to an unexpected effect: The conventional monotonic decrease of the population of parametrically injected magnons is accompanied by an explosive behavior of electromagnetic radiation at the magnon frequency. The developed theory shows that this explosion is caused by a nonlinear energy transfer from parametrically driven short-wavelength dipolar-exchange magnons to a long-wavelength dipolar magnon mode effectively coupled to an electromagnetic wave.

  15. Prevalence and correlates of explosive anger among pregnant and post-partum women in post-conflict Timor-Leste

    PubMed Central

    Rees, Susan; Tam, Natalino; Mohsin, Mohammed; Tay, Alvin Kuowei; Tol, Wietse

    2015-01-01

    Background Little is known about explosive anger as a response pattern among pregnant and post-partum women in conflict-affected societies. Aims To investigate the prevalence and correlates of explosive anger among this population in Timor-Leste. Method We assessed traumatic events, intimate partner violence, an index of adversity, explosive anger, psychological distress and post-traumatic stress disorder among 427 women (257 in the second trimester of pregnancy, 170 who were 3–6 months post-partum) residing in two districts of Timor-Leste (response >99%). Results Two-fifths (43.6%) had explosive anger. Levels of functional impairment were related to frequency of explosive anger episodes. Explosive anger was associated with age (>35 years), being married, low levels of education, being employed, traumatic event count, ongoing adversity and intimate partner violence. Conclusions A combination of social programmes and novel psychological therapies may assist in reducing severe anger among pregnant and post-partum women in conflict-affected countries such as Timor-Leste. Declaration of interest None. Copyright and usage © The Royal College of Psychiatrists 2015. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence. PMID:27703721

  16. The world population explosion: causes, backgrounds and projections for the future

    PubMed Central

    Van Bavel, J.

    2013-01-01

    At the beginning of the nineteenth century, the total world population crossed the threshold of 1 billion people for the first time in the history of the homo sapiens sapiens. Since then, growth rates have been increasing exponentially, reaching staggeringly high peaks in the 20th century and slowing down a bit thereafter. Total world population reached 7 billion just after 2010 and is expected to count 9 billion by 2045. This paper first charts the differences in population growth between the world regions. Next, the mechanisms behind unprecedented population growth are explained and plausible scenarios for future developments are discussed. Crucial for the long term trend will be the rate of decline of the number of births per woman, called total fertility. Improvements in education, reproductive health and child survival will be needed to speed up the decline of total fertility, particularly in Africa. But in all scenarios, world population will continue to grow for some time due to population momentum. Finally, the paper outlines the debate about the consequences of the population explosion, involving poverty and food security, the impact on the natural environment, and migration flows. Key words: Fertility, family planning, world population, population growth, demographic transition, urbanization, population momentum, population projections. PMID:24753956

  17. Normal and leukaemic human haemopoietic cells in diffusion chamber. A morphological and functional CFU-C study.

    PubMed

    Laurent, M; Clémancey-Marcille, G; Hollard, D

    1980-03-01

    Leukaemic human bone marrow and peripheral blood cells were cultured for 25 d in diffusion chambers implanted into cyclophosphamide treated mice. Normal bone marrow cells were cultured simultaneously. These cells were studied both morphologically and functionally (CFU-C). The leukaemic cells behaved heterogeneously, 2 groups being distinguishable in accordance with their initial in vitro growth pattern (1: no growth or microcluster growth. 2: macrocluster growth). Group I showed progressive cellular death with a diminution of granulocytic progenitors and the appearance of a predominantly macrophagic population. This behaviour resembled that of the control group. The initial microcluster growth pattern remained identical throughout the entire culture period. Group 2, after considerable cellular death up to d 5, showed an explosive proliferation of the granulocytic progenitors and incomplete differentiation (up to myelocyte). The initial macrocluster growth pattern remained identical.

  18. Regional Small-Event Identification Using Networks and Arrays of Seismic and Acoustic Sensors

    DTIC Science & Technology

    2006-04-01

    ground displacement and excite infra - sonic waves in the atmosphere (Blanc, 1989) near-surface explosions are much more efficient sources of...valuable advice on the portable infrasonic deployment at MNTA. Several of the images in this report are attributable to David Anderson at Southern...populations. This study has focused on seismic observations from mining explosions. There is increasing evidence that infrasonic observations may help in

  19. Eruptive history, current activity and risk estimation using geospatial information in the Colima volcano, Mexico

    NASA Astrophysics Data System (ADS)

    Suarez-Plascencia, C.; Camarena-Garcia, M.; Nunez-Cornu, F. J.; Flores-Peña, S.

    2013-12-01

    Colima volcano, also known as Volcan de Fuego (19 30.696 N, 103 37.026 W), is located on the border between the states of Jalisco and Colima, and is the most active volcano in Mexico. In January 20, 1913, Colima had its biggest explosion of the twentieth century, with VEI 4, after the volcano had been dormant for almost 40 years. In 1961, a dome reached the northeastern edge of the crater and started a new lava flow, and from this date maintains constant activity. In February 10, 1999, a new explosion occurred at the summit dome. The activity during the 2001-2005 period was the most intense, but did not exceed VEI 3. The activity resulted in the formation of domes and their destruction after explosive events. The explosions originated eruptive columns, reaching altitudes between 4,500 and 9,000 masl, further pyroclastic flows reaching distances up to 3.5 km from the crater. During the explosive events, ash emissions were generated in all directions reaching distances up to 100 km, slightly affecting the nearby villages: Tuxpan, Tonila, Zapotlan, Cuauhtemoc, Comala, Zapotitlan de Vadillo and Toliman. During 2005 to July 2013, this volcano has had an intense effusive-explosive activity; similar to the one that took place during the period of 1890 through 1905. That was before the Plinian eruption of 1913, where pyroclastic flows reached a distance of 15 km from the crater. In this paper we estimate the risk of Colima volcano through the analysis of the vulnerability variables, hazard and exposure, for which we use: satellite imagery, recurring Fenix helicopter over flights of the state government of Jalisco, the use of the images of Google Earth and the population census 2010 INEGI. With this information and data identified changes in economic activities, development, and use of land. The expansion of the agricultural frontier in the lower sides of the volcano Colima, and with the advancement of traditional crops of sugar cane and corn, increased the growth of avocado orchards and fruits like blueberries, raspberries, and blackberries within the radius of 15 km from the crater. The population dynamics in the Colima volcano area had a population of 552,954 inhabitants in 2010, and a growth at an annual rate of 1.6 percent of the total population. 60 percent of the populations live in 105 towns with a population less than 250 inhabitants. Also, the region showed an increase in vulnerability for the development of economic activities, supported by the highway, railway, natural gas pipelines and electrical infrastructure that connect to the Port of Manzanillo to Guadalajara city. With the use of geospatial information quantify the vulnerability, together with the hazard maps and exposure, enabled us to build the following volcanic risk maps: a) Exclusion areas and moderate hazard for explosive events (ballistic) and pyroclastic flows, b) Hazard map of lahars and debris flow, and c) Hazard map of ash-fall. The geospatial database, a GIS mapping and current volcano monitoring, are the basis of the Operational Plan Colima Volcano. Civil Protection by the state of Jalisco and the updating of urban development plans of municipalities converge on the volcano. These instruments of land planning will help reduce volcanic risk in the region.

  20. Rapid Population Growth-Cause or Result of Global Problems?

    ERIC Educational Resources Information Center

    Schwartz, Richard H.

    Explosive population growth is a symptom of the world's unjust and inequitable social, political, and economic conditions. The current rate of growth is staggering, particularly in the cities of the underdeveloped countries. While some progress has been made in slowing population growth, several factors still contribute to its momentum. One of…

  1. Family Planning, Population Problems and the Secondary School Curriculum.

    ERIC Educational Resources Information Center

    Millstone, Dorothy L.

    In this booklet, specialists in varied academic disciplines seek to determine how the classroom can function to sharpen man's understanding of the population problems and to prod him to the application of reason. Demographer and sociologist Philip Hauser places the problem in the framework of explosive world population growth, and highlights the…

  2. Biological control via "ecological" damping: An approach that attenuates non-target effects.

    PubMed

    Parshad, Rana D; Quansah, Emmanuel; Black, Kelly; Beauregard, Matthew

    2016-03-01

    In this work we develop and analyze a mathematical model of biological control to prevent or attenuate the explosive increase of an invasive species population, that functions as a top predator, in a three-species food chain. We allow for finite time blow-up in the model as a mathematical construct to mimic the explosive increase in population, enabling the species to reach "disastrous", and uncontrollable population levels, in a finite time. We next improve the mathematical model and incorporate controls that are shown to drive down the invasive population growth and, in certain cases, eliminate blow-up. Hence, the population does not reach an uncontrollable level. The controls avoid chemical treatments and/or natural enemy introduction, thus eliminating various non-target effects associated with such classical methods. We refer to these new controls as "ecological damping", as their inclusion dampens the invasive species population growth. Further, we improve prior results on the regularity and Turing instability of the three-species model that were derived in Parshad et al. (2014). Lastly, we confirm the existence of spatiotemporal chaos. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. Workshop on Systems Interconnexions: Standardization, Uniformity and Co-ordination in Population/Family Planning Information Network (Kuala Lumpur, Malaysia, April 12-16, 1976).

    ERIC Educational Resources Information Center

    Hawaii Univ., Honolulu. East-West Center.

    The "information explosion" in the field of population has created a need for proper identification, systematization, dissemination, and utilization of population information. To help meet these needs in the Asian and Pacific regions, the Clearinghouse and Information Section of the Population Division of ESCAP (Economic and Social…

  4. Collisional cascading - The limits of population growth in low earth orbit

    NASA Technical Reports Server (NTRS)

    Kessler, Donald J.

    1991-01-01

    Random collisions between made-made objects in earth orbit will lead to a significant source of orbital debris, but there are a number of uncertainties in these models, and additional analysis and data are required to fully characterize the future environment. However, the nature of these uncertainties are such that while the future environment is uncertain, the fact that collisions will control the future environment is less uncertain. The data that already exist is sufficient to show that cascading collisions will control the future debris environment with no, or very minor increases in the current low-earth-orbit population. Two populations control this process: explosion fragments and expended rocket bodies and payloads. Practices are already changing to limit explosions in low earth orbit; it is necessary to begin limiting the number of expended rocket bodies and payloads in orbit.

  5. The transition from explosive to effusive eruptive regime: The example of the 1912 Novarupta eruption, Alaska

    USGS Publications Warehouse

    Adams, N.K.; Houghton, Bruce F.; Fagents, S.A.; Hildreth, W.

    2006-01-01

    The shift from explosive to effusive silicic volcanism seen in many historical eruptions reflects a change in the style of degassing of erupted magma. This paper focuses on such a transition during the largest eruption of the twentieth century, the 1912 eruption of Novarupta. The transition is recorded in a dacite block bed, which covers an elliptical area of 4 km2 around the vent. Approximately 700 studied blocks fall into four main lithologic categories: (1) pumiceous, (2) dense, (3) flow-banded dacites, and (4) welded breccias. Textural analyses of the blocks indicate portions of the melt underwent highly variable degrees of outgassing. Vesicle populations show features characteristic of bubble coalescence and collapse. A decrease in measured vesicularity and increased evidence for bubble collapse compared with pumice from earlier Plinian episodes mark the transition from closed- to open-system degassing. Block morphology and textures strongly suggest the magma was first erupted as a relatively gas-rich lava dome/plug, but incomplete out-gassing led to explosive disruption. Heterogeneous degassing of ascending magma began in Plinian Episode III and resulted in instability during Episode IV dome growth and a (series of) Vulcanian explosion(s). Modeling of the dynamics of explosion initiation and ejecta dispersal indicates that a significant concentration in gas is required to produce the explosions responsible for the observed block field dispersal. The amount of gas available in the hot pumiceous dome material appears to have been inadequate to drive the explosion(s); therefore, external water most likely contributed to the destruction. ?? 2006 Geological Society of America.

  6. RDX binds to the convulsant site of the GABAA receptor and increases spontaneous firing rates of cortical neurons in vitro

    EPA Science Inventory

    RDX (hexahydro-1 ,3,5-trinitro-1 ,3,5-triazine, hexogen, Royal Demolition eXplosive) is an explosive widely used by the military and has been found in soil and ground water in and surrounding training ranges, creating potential hazards to the environment and human health. Oral RD...

  7. Constraints on core-collapse supernova progenitors from explosion site integral field spectroscopy

    NASA Astrophysics Data System (ADS)

    Kuncarayakti, H.; Anderson, J. P.; Galbany, L.; Maeda, K.; Hamuy, M.; Aldering, G.; Arimoto, N.; Doi, M.; Morokuma, T.; Usuda, T.

    2018-05-01

    Context. Observationally, supernovae (SNe) are divided into subclasses according to their distinct characteristics. This diversity naturally reflects the diversity in the progenitor stars. It is not entirely clear, however, how different evolutionary paths leading massive stars to become an SN are governed by fundamental parameters such as progenitor initial mass and metallicity. Aims: This paper places constraints on progenitor initial mass and metallicity in distinct core-collapse SN subclasses through a study of the parent stellar populations at the explosion sites. Methods: Integral field spectroscopy (IFS) of 83 nearby SN explosion sites with a median distance of 18 Mpc has been collected and analysed, enabling detection and spectral extraction of the parent stellar population of SN progenitors. From the parent stellar population spectrum, the initial mass and metallicity of the coeval progenitor are derived by means of comparison to simple stellar population models and strong-line methods. Additionally, near-infrared IFS was employed to characterise the star formation history at the explosion sites. Results: No significant metallicity differences are observed among distinct SN types. The typical progenitor mass is found to be highest for SN type Ic, followed by type Ib, then types IIb and II. Type IIn is the least associated with young stellar populations and thus massive progenitors. However, statistically significant differences in progenitor initial mass are observed only when comparing SNe IIn with other subclasses. Stripped-envelope SN progenitors with initial mass estimates lower than 25 M⊙ are found; they are thought to be the result of binary progenitors. Confirming previous studies, these results support the notion that core-collapse SN progenitors cannot arise from single-star channels only, and both single and binary channels are at play in the production of core-collapse SNe. Near-infrared IFS suggests that multiple stellar populations with different ages may be present in some of the SN sites. As a consequence, there could be a non-negligible amount of contamination from old populations, and therefore the individual age estimates are effectively lower limits. Based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere under ESO programmes 089.D-0367, 091.D-0482, 093.D-0318, 094.D-0290, and 095.D-0172

  8. Design optimization of Cassegrain telescope for remote explosive trace detection

    NASA Astrophysics Data System (ADS)

    Bhavsar, Kaushalkumar; Eseller, K. E.; Prabhu, Radhakrishna

    2017-10-01

    The past three years have seen a global increase in explosive-based terror attacks. The widespread use of improvised explosives and anti-personnel landmines have caused thousands of civilian casualties across the world. Current scenario of globalized civilization threat from terror drives the need to improve the performance and capabilities of standoff explosive trace detection devices to be able to anticipate the threat from a safe distance to prevent explosions and save human lives. In recent years, laser-induced breakdown spectroscopy (LIBS) is an emerging approach for material or elemental investigations. All the principle elements on the surface are detectable in a single measurement using LIBS and hence, a standoff LIBS based method has been used to remotely detect explosive traces from several to tens of metres distance. The most important component of LIBS based standoff explosive trace detection system is the telescope which enables remote identification of chemical constituents of the explosives. However, in a compact LIBS system where Cassegrain telescope serves the purpose of laser beam delivery and light collection, need a design optimization of the telescope system. This paper reports design optimization of a Cassegrain telescope to detect explosives remotely for LIBS system. A design optimization of Schmidt corrector plate was carried out for Nd:YAG laser. Effect of different design parameters was investigated to eliminate spherical aberration in the system. Effect of different laser wavelengths on the Schmidt corrector design was also investigated for the standoff LIBS system.

  9. Assessing Seasonal Risks for the Introduction and Mosquito-borne Spread of Zika Virus in Europe.

    PubMed

    Rocklöv, Joacim; Quam, Mikkel Brandon; Sudre, Bertrand; German, Matthew; Kraemer, Moritz U G; Brady, Oliver; Bogoch, Isaac I; Liu-Helmersson, Jing; Wilder-Smith, Annelies; Semenza, Jan C; Ong, Mark; Aaslav, Kaja Kaasik; Khan, Kamran

    2016-07-01

    The explosive Zika virus epidemic in the Americas is amplifying spread of this emerging pathogen into previously unaffected regions of the world, including Europe (Gulland, 2016), where local populations are immunologically naïve. As summertime approaches in the northern hemisphere, Aedes mosquitoes in Europe may find suitable climatic conditions to acquire and subsequently transmit Zika virus from viremic travellers to local populations. While Aedes albopictus has proven to be a vector for the transmission of dengue and chikungunya viruses in Europe (Delisle et al., 2015; ECDC, n.d.) there is growing experimental and ecological evidence to suggest that it may also be competent for Zika virus(Chouin-Carneiro et al., 2016; Grard et al., 2014; Li et al., 2012; Wong et al., 2013). Here we analyze and overlay the monthly flows of airline travellers arriving into European cities from Zika affected areas across the Americas, the predicted monthly estimates of the basic reproduction number of Zika virus in areas where Aedes mosquito populations reside in Europe (Aedes aegypti in Madeira, Portugal and Ae. albopictus in continental Europe), and human populations living within areas where mosquito-borne transmission of Zika virus may be possible. We highlight specific geographic areas and timing of risk for Zika virus introduction and possible spread within Europe to inform the efficient use of human disease surveillance, vector surveillance and control, and public education resources. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  10. The New Rural Society.

    ERIC Educational Resources Information Center

    Goldmark, Peter C.

    The population explosion and the trend to urban-suburban living means that 80% of the nation's population lives on less than 10% of the land. A long-term solution to this problem calls for a total change in our population distribution as well as our life style--and the key to this plan lies in new applications for existing communication…

  11. Six-year longitudinal study of pathways leading to explosive anger involving the traumas of recurrent conflict and the cumulative sense of injustice in Timor-Leste.

    PubMed

    Silove, Derrick; Mohsin, Mohammed; Tay, Alvin Kuowei; Steel, Zachary; Tam, Natalino; Savio, Elisa; Da Costa, Zelia Maria; Rees, Susan

    2017-10-01

    Cumulative evidence suggests that explosive anger may be a common reaction among survivors of mass conflict. However, little is known about the course of explosive anger in the years following mass conflict, or the psychosocial factors that influence the trajectory of that reaction pattern. We examined these issues in a 6-year longitudinal study (2004-2010) conducted among adult residents of a rural and an urban village in Timor-Leste (n = 1022). We derived a brief, context-specific index of explosive anger using qualitative methods. Widely used measures of post-traumatic stress disorder (PTSD) and severe psychological distress were calibrated to the Timor context. We developed an index of the cumulative sense of injustice related to consecutive historical periods associated with conflict in Timor-Leste. We applied partial structural equation modeling (SEM) to examine pathways from baseline explosive anger, socio-demographic factors, recurrent trauma, mental health indices (PTSD, severe psychological distress) and the sense of injustice, to explosive anger. Half of the sample with explosive anger at baseline continued to report that reaction pattern after 6 years; and a third of those who did not report explosive anger at baseline developed the response by follow-up. A symmetrical pattern of younger age, female gender and the trauma count for the preceding historical period predicted explosive anger at each assessment point. The sense of injustice was related to explosive anger at follow-up. Explosive anger was associated with impairment in functioning and conflict with the intimate partner and wider family. Sampling constraints caution against generalizing our findings to other populations. Nevertheless, our data suggest that explosive anger may persist for a prolonged period of time following mass conflict and that the response pattern is initiated and maintained by recurrent trauma exposure associated with a sense of injustice. Averting recurrence of mass violence and addressing persisting feelings of injustice may assist in reducing anger in conflict-affected societies. Whether explosive anger at the individual level increases risk of collective violence under conditions of social and political instability requires further inquiry.

  12. Synthesis and First Principles Investigation of HMX/NMP Cocrystal Explosive

    NASA Astrophysics Data System (ADS)

    Lin, He; Zhu, Shun-Guan; Zhang, Lin; Peng, Xin-Hua; LI, Hong-Zhen

    2013-10-01

    1,3,5,7-Tetranitro-l,3,5,7-tetrazocine (HMX)/N-methyl-2-pyrrolidone (NMP) cocrystal explosive was prepared by a solution evaporation method. This cocrystal explosive crystallized in the trigonal system (space group ? ), with cell parameters a = 16.605(8) Å and c = 31.496(4) Å. Theoretical investigations of the formation mechanism of HMX/NMP cocrystal were carried out in Cambridge serial total energy package (CASTEP) based on dispersion-corrected density functional theory (DFT-D) with a plane wave scheme. The exchange-correlation potential was treated with the Perdew-Burke-Ernzerhof function of generalized gradient approximation, and dispersion force was correlated using Grimme's method. The band structure, density of states, projected density of states, and Mulliken populations were calculated at the generalized gradient approximation level. The results showed that the main host-guest interactions in HMX/NMP cocrystal were hydrogen bonds and stacking interactions, which were the same as those analyzed using X-ray diffraction. Theoretical investigations of HMX/NMP cocrystal explosive may provide the basis for the preparation of cocrystal explosive composed of HMX and energetic materials.

  13. Nucleosynthesis in neutrino-driven, aspherical Population III supernovae

    NASA Astrophysics Data System (ADS)

    Fujimoto, Shin-ichiro; Hashimoto, Masa-aki; Ono, Masaomi; Kotake, Kei

    2012-09-01

    We investigate explosive nucleosynthesis during neutrino-driven, aspherical supernova (SN) explosion aided by standing accretion shock instability (SASI), based on two-dimensional hydrodynamic simulations of the explosion of 11, 15, 20, 25, 30 and 40M ⊙ stars with zero metallicity. The magnitude and asymmetry of the explosion energy are estimated with simulations, for a given set of neutrino luminosities and temperatures, not as in the previous study in which the explosion is manually and spherically initiated by means of a thermal bomb or a piston and also some artificial mixing procedures are applied for the estimate of abundances of the SN ejecta. By post-processing calculations with a large nuclear reaction network, we have evaluated abundances and masses of ejecta from the aspherical SNe. We find that matter mixing induced via SASI is important for the abundant production of nuclei with atomic number >= 21, in particular Sc, which is underproduced in the spherical models without artificial mixing. We also find that the IMF-averaged abundances are similar to those observed in extremely metal poor stars. However, observed [K/Fe] cannot be reproduced with our aspherical SN models.

  14. No Nation Alone

    ERIC Educational Resources Information Center

    Chase, Stuart

    1976-01-01

    Summarized are 13 major problems facing every country in the world today. Problems include: disarmament, population explosion, pollution, energy, conservation of natural resources, transportation, communications, and health. (SL)

  15. P sub n from the Nevada Test Site

    DTIC Science & Technology

    1988-12-15

    reviewed and is approved for publication" JAMES0- t1IC Z--C J (TEX S C. BAkTIS CnLract Manager Acting Chief Solid Earth Geophysics Branch Solid Earth...high frequency Pn . The data base being used in the development consists of signals from explosions and earthquakes recorded on the western U.S. digital...measured quantitatively by correlating the average explosiorn ?n trace wiLh a data base of explosion and earthquake signals. The populations

  16. [Mind the explosion? The evolution of safety at work in anaesthesiology].

    PubMed

    Petermann, Heike

    2015-11-01

    The evolution of safety in anaesthesiology is characterized by 2 aspects: exposure of anaesthetic staff by volatile anaesthetics and fire as well as explosions in combination with those. In the 20th century, the exposure of staff in the operating room became more and more important. Trigger for the fatal complications were gas lights in combination with chloroform. Later oxygen and inhalation anaesthetics caused explosions and fires. Therefore safety rules were implemented in the 1980s in the Federal Republic of Germany. These were valid for application anaesthetics including apparatus and configuration of operating rooms. The only imponderability is still the human factor.

  17. Identifying ecological corridors for Amur tigers (Panthera tigris altaica) and Amur leopards (Panthera pardus orientalis).

    PubMed

    Miquelle, Dale G; Rozhnov, Vyachaslav V; Ermoshin, Victor; Murzin, Andre A; Nikolaev, Igor G; Hernandez-Blanco, Jose A; Naidenko, Sergie V

    2015-07-01

    The rapid explosion of human populations and the associated development of human-dominated landscapes have drastically reduced and fragmented habitat for tigers (Panthera tigris) and leopards (Panthera pardus) across Asia, resulting in multiple small populations. However, Amur tiger (Panthera tigris altaica) habitat in Russia has remained largely interconnected, except for a break between tigers in southwest Primorye and the southern Sikhote-Alin Mountains. This habitat patch in southwest Primorye also retains the last population of Amur leopards (Panthera pardus orientalis). Genetic differentiation of tigers in southwest Primorye and the Sikhote-Alin Mountains along with survey data suggest that habitat fragmentation is limiting movement of tigers and leopards across the Razdolnaya River basin. We looked at historical and recent survey data on tigers and leopards and mapped existing cover types to examine land-use patterns of both large felids and humans in the development strip along the Razdolnaya River. We then used least-cost distance analyses to identify the most effective potential corridor to retain connectivity for large felids between Land of the Leopard National Park and Ussuriskii Zapovednik (Reserve). We identified a single potential corridor that still exists with a total distance of 62.5 km from Land of the Leopard National Park to Ussuriskii Zapovednik, mostly (93%) through forested habitat. We recommend formal recognition of a Razdolnaya ecological corridor and provide specific recommendations for each of 3 proposed management sections. © 2015 International Society of Zoological Sciences, Institute of Zoology/Chinese Academy of Sciences and Wiley Publishing Asia Pty Ltd.

  18. Progressing the analysis of Improvised Explosive Devices: Comparative study for trace detection of explosive residues in handprints by Raman spectroscopy and liquid chromatography.

    PubMed

    Zapata, Félix; de la Ossa, Mª Ángeles Fernández; Gilchrist, Elizabeth; Barron, Leon; García-Ruiz, Carmen

    2016-12-01

    Concerning the dreadful global threat of terrorist attacks, the detection of explosive residues in biological traces and marks is a current need in both forensics and homeland security. This study examines the potential of Raman microscopy in comparison to liquid chromatography (ion chromatography (IC) and reversed-phase high performance liquid chromatography (RP-HPLC)) to detect, identify and quantify residues in human handmarks of explosives and energetic salts commonly used to manufacture Improvised Explosive Devices (IEDs) including dynamite, ammonium nitrate, single- and double-smokeless gunpowders and black powder. Dynamite, ammonium nitrate and black powder were detected through the identification of the energetic salts by Raman spectroscopy, their respective anions by IC, and organic components by RP-HPLC. Smokeless gunpowders were not detected, either by Raman spectroscopy or the two liquid chromatography techniques. Several aspects of handprint collection, sample treatment and a critical comparison of the identification of compounds by both techniques are discussed. Raman microscopy and liquid chromatography were shown to be complementary to one another offering more comprehensive information for trace explosives analysis. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. Grand challenges in evolutionary and population genetics: The importance of integrating epigenetics, genomics, modeling, and experimentation

    Treesearch

    Samuel A. Cushman

    2014-01-01

    This is a time of explosive growth in the fields of evolutionary and population genetics, with whole genome sequencing and bioinformatics driving a transformative paradigm shift (Morozova and Marra, 2008). At the same time, advances in epigenetics are thoroughly transforming our understanding of evolutionary processes and their implications for populations, species and...

  20. Space Weather: Linking Stellar Explosions to the Human Endeavor

    NASA Astrophysics Data System (ADS)

    Knipp, Delores

    2017-06-01

    Arguably humans have flourished as a result of stellar explosions; we are, after all, stardust. Nonetheless, rapid technology advances of the last 200 years sometimes put society and individuals on a collision course with the natural variability of stellar and solar atmospheres. Human space exploration, routine satellite navigation system applications, aviation safety, and electric power grids are examples of such vulnerable endeavors. In this presentation I will outline how global society relies on ‘normal’ solar and stellar emissions, yet becomes susceptible to extremes of these emissions. The imprints of these astronomical-terrestrial interactions abound. In particular, I will highlight ways in which stellar/solar bursts link with our space-atmosphere-interaction region, producing multi-year patterns in cosmic ray detection, gorgeous aurora, and deep concern for good order and function of global community.

  1. Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair

    PubMed Central

    Campbell, Brittany B; Ungerleider, Nathan; Light, Nicholas; Wu, Tong; LeCompte, Kimberly G; Goksenin, A Yasemin; Bunnell, Bruce A; Tabori, Uri; Shlien, Adam

    2018-01-01

    Tumors defective for DNA polymerase (Pol) ε proofreading have the highest tumor mutation burden identified. A major unanswered question is whether loss of Pol ε proofreading by itself is sufficient to drive this mutagenesis, or whether additional factors are necessary. To address this, we used a combination of next generation sequencing and in vitro biochemistry on human cell lines engineered to have defects in Pol ε proofreading and mismatch repair. Absent mismatch repair, monoallelic Pol ε proofreading deficiency caused a rapid increase in a unique mutation signature, similar to that observed in tumors from patients with biallelic mismatch repair deficiency and heterozygous Pol ε mutations. Restoring mismatch repair was sufficient to suppress the explosive mutation accumulation. These results strongly suggest that concomitant suppression of mismatch repair, a hallmark of colorectal and other aggressive cancers, is a critical force for driving the explosive mutagenesis seen in tumors expressing exonuclease-deficient Pol ε. PMID:29488881

  2. Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair.

    PubMed

    Hodel, Karl P; de Borja, Richard; Henninger, Erin E; Campbell, Brittany B; Ungerleider, Nathan; Light, Nicholas; Wu, Tong; LeCompte, Kimberly G; Goksenin, A Yasemin; Bunnell, Bruce A; Tabori, Uri; Shlien, Adam; Pursell, Zachary F

    2018-02-28

    Tumors defective for DNA polymerase (Pol) ε proofreading have the highest tumor mutation burden identified. A major unanswered question is whether loss of Pol ε proofreading by itself is sufficient to drive this mutagenesis, or whether additional factors are necessary. To address this, we used a combination of next generation sequencing and in vitro biochemistry on human cell lines engineered to have defects in Pol ε proofreading and mismatch repair. Absent mismatch repair, monoallelic Pol ε proofreading deficiency caused a rapid increase in a unique mutation signature, similar to that observed in tumors from patients with biallelic mismatch repair deficiency and heterozygous Pol ε mutations. Restoring mismatch repair was sufficient to suppress the explosive mutation accumulation. These results strongly suggest that concomitant suppression of mismatch repair, a hallmark of colorectal and other aggressive cancers, is a critical force for driving the explosive mutagenesis seen in tumors expressing exonuclease-deficient Pol ε. © 2018, Hodel et al.

  3. Attogram sensing of trinitrotoluene with a self-assembled molecular gelator.

    PubMed

    Kartha, Kalathil K; Babu, Sukumaran S; Srinivasan, Sampath; Ajayaghosh, Ayyappanpillai

    2012-03-14

    Detection of explosives is of utmost importance due to the threat to human security as a result of illegal transport and terrorist activities. Trinitrotoluene (TNT) is a widely used explosive in landmines and military operations that contaminates the environment and groundwater, posing a threat to human health. Achieving the detection of explosives at a sub-femtogram level using a molecular sensor is a challenge. Herein we demonstrate that a fluorescent organogelator exhibits superior detection capability for TNT in the gel form when compared to that in the solution state. The gel when coated on disposable paper strips detects TNT at a record attogram (ag, 10(-18) g) level (∼12 ag/cm(2)) with a detection limit of 0.23 ppq. This is a simple and low-cost method for the detection of TNT on surfaces or in aqueous solutions in a contact mode, taking advantage of the unique molecular packing of an organogelator and the associated photophysical properties.

  4. The case for addressing explosive weapons: conflict, violence and health.

    PubMed

    Rappert, Brian; Moyes, Richard; Lang, Iain

    2012-12-01

    In recent years, states and non-governmental organizations have expressed concern about the humanitarian consequences of the category of technologies labelled 'explosive weapons', particularly in relation to their use in populated areas. This article seeks to outline the magnitude of these consequences as well as what can be done to reduce harms. In particular, it makes a case for how health approaches could help prevent the harms associated with this category of weapons. Attention is given to the types of evidence and argument that might be required to characterize explosive weapons. An overarching aim is to consider how alternative ways of understanding weapons and violence can create new opportunities for addressing harms from conflict. Copyright © 2012 Elsevier Ltd. All rights reserved.

  5. Some Aspects of Sustainable Development in Kindergartens in Slovenia

    ERIC Educational Resources Information Center

    Vodopivec, Jurka Lepicnik

    2011-01-01

    Aspects of environmental crisis (industrialization, explosive growth of population and urbanization) have a negative effect on the environment. However, they also impact the mentality of population (for example, urbanization has lead to the decreasing numbers of adults and children having a direct contact with the natural environment).…

  6. Climatic and cultural changes in the west Congo Basin forests over the past 5000 years

    PubMed Central

    Oslisly, Richard; White, Lee; Bentaleb, Ilham; Favier, Charly; Fontugne, Michel; Gillet, Jean-François; Sebag, David

    2013-01-01

    Central Africa includes the world's second largest rainforest block. The ecology of the region remains poorly understood, as does its vegetation and archaeological history. However, over the past 20 years, multidisciplinary scientific programmes have enhanced knowledge of old human presence and palaeoenvironments in the forestry block of Central Africa. This first regional synthesis documents significant cultural changes over the past five millennia and describes how they are linked to climate. It is now well documented that climatic conditions in the African tropics underwent significant changes throughout this period and here we demonstrate that corresponding shifts in human demography have had a strong influence on the forests. The most influential event was the decline of the strong African monsoon in the Late Holocene, resulting in serious disturbance of the forest block around 3500 BP. During the same period, populations from the north settled in the forest zone; they mastered new technologies such as pottery and fabrication of polished stone tools, and seem to have practised agriculture. The opening up of forests from 2500 BP favoured the arrival of metallurgist populations that impacted the forest. During this long period (2500–1400 BP), a remarkable increase of archaeological sites is an indication of a demographic explosion of metallurgist populations. Paradoxically, we have found evidence of pearl millet (Pennisetum glaucum) cultivation in the forest around 2200 BP, implying a more arid context. While Early Iron Age sites (prior to 1400 BP) and recent pre-colonial sites (two to eight centuries BP) are abundant, the period between 1600 and 1000 BP is characterized by a sharp decrease in human settlements, with a population crash between 1300 and 1000 BP over a large part of Central Africa. It is only in the eleventh century that new populations of metallurgists settled into the forest block. In this paper, we analyse the spatial and temporal distribution of 328 archaeological sites that have been reliably radiocarbon dated. The results allow us to piece together changes in the relationships between human populations and the environments in which they lived. On this basis, we discuss interactions between humans, climate and vegetation during the past five millennia and the implications of the absence of people from the landscape over three centuries. We go on to discuss modern vegetation patterns and African forest conservation in the light of these events. PMID:23878334

  7. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kuncarayakti, Hanindyo; Maeda, Keiichi; Doi, Mamoru

    Integral field spectroscopy of 11 Type Ib/Ic supernova (SN Ib/Ic) explosion sites in nearby galaxies has been obtained using UH88/SNIFS and Gemini-N/GMOS. The use of integral field spectroscopy enables us to obtain both spatial and spectral information about the explosion site, enabling the identification of the parent stellar population of the SN progenitor star. The spectrum of the parent population provides metallicity determination via strong-line method and age estimation obtained via comparison with simple stellar population models. We adopt this information as the metallicity and age of the SN progenitor, under the assumption that it was coeval with the parentmore » stellar population. The age of the star corresponds to its lifetime, which in turn gives the estimate of its initial mass. With this method we were able to determine both the metallicity and initial (zero-age main sequence) mass of the progenitor stars of SNe Ib and Ic. We found that on average SN Ic explosion sites are more metal-rich and younger than SN Ib sites. The initial mass of the progenitors derived from parent stellar population age suggests that SN Ic has more massive progenitors than SN Ib. In addition, we also found indication that some of our SN progenitors are less massive than {approx}25 M{sub Sun }, indicating that they may have been stars in a close binary system that have lost their outer envelope via binary interactions to produce SNe Ib/Ic, instead of single Wolf-Rayet stars. These findings support the current suggestions that both binary and single progenitor channels are in effect in producing SNe Ib/Ic. This work also demonstrates the power of integral field spectroscopy in investigating SN environments and active star-forming regions.« less

  8. Sources of orbital debris and the projected environment for future spacecraft

    NASA Technical Reports Server (NTRS)

    Kessler, D. J.

    1980-01-01

    The major source of the nearly 5000 objects currently observed orbiting the earth is from rocket explosions. These explosions have almost certainly produced an even larger unobserved population. If the current trend continues, collisions between orbiting fragments and other space objects could be frequent. By the year 2000 satellite fragmentation by hypervelocity collisions could become the major source of earth orbiting objects, resulting in a self propagating debris belt. The flux within this belt could exceed the meteoroid flux, affecting future spacecraft design.

  9. Minutes of the Explosives Safety Seminar (25th) Held in Anaheim, California on 18-20 August 1992. Volume 3

    DTIC Science & Technology

    1992-08-20

    the potential health and safety effects posed by the hazardous waste and ordnance at the site. When the COE began our studies, the media began to...all with the contamination can still be affected through the food chain. This is not true for OEW. The population at risk is effectively limited to...a serious health hazard. The effects of ordnance and explosive waste exposures are much more immediate, and easier to measure. Most of the time

  10. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dreger, Douglas S.; Ford, Sean R.; Walter, William R.

    Research was carried out investigating the feasibility of using a regional distance seismic waveform moment tensor inverse procedure to estimate source parameters of nuclear explosions and to use the source inversion results to develop a source-type discrimination capability. The results of the research indicate that it is possible to robustly determine the seismic moment tensor of nuclear explosions, and when compared to natural seismicity in the context of the a Hudson et al. (1989) source-type diagram they are found to separate from populations of earthquakes and underground cavity collapse seismic sources.

  11. Controlled human infection with RSV: The opportunities of experimental challenge.

    PubMed

    Habibi, Maximillian S; Chiu, Christopher

    2017-01-11

    Despite the recent explosion in RSV vaccine development, there remain substantial hurdles to overcome before licensing of effective vaccines will allow widespread use, particularly in high-risk populations. Incomplete understanding of mechanisms and correlates of protection against RSV mean that, for the time being, successful RSV vaccines must directly demonstrate efficacy, which necessitates large and costly clinical trials in naturally infected patients. To mitigate the risks inherent in progressing to these late-stage trials, experimental human RSV infection studies have recently been re-established, representing the interface between pre-clinical models and observational studies of patients. Not only can they be used for early proof-of-concept clinical trials to test vaccine efficacy, but human challenge studies also offer the potential to better understand protective immunity against RSV infection to improve vaccine design and delivery. In the past, controlled human infection studies with RSV have been instrumental in elucidating the influence of factors such as route of infection and type of inoculum on the course of disease. Recently, efficacy trials of novel RSV antiviral drugs have also been successfully undertaken. Now, with advances in technology, detailed investigations of human mucosal immunity in the RSV-infected airway are possible. These have indicated defects in RSV-induced humoral and CD8+ T cell immunity that may contribute to the recurrent symptomatic infection that occurs throughout life and should be circumvented by optimal vaccines. Here, we discuss the insights derived from RSV human challenge models; the major impediments to their more widespread uptake; and their potential benefit in accelerating vaccine development, including future directions to further enhance the relevance of these models to at-risk patient populations. Crown Copyright © 2016. Published by Elsevier Ltd. All rights reserved.

  12. Computing the stresses and deformations of the human eye components due to a high explosive detonation using fluid-structure interaction model.

    PubMed

    Karimi, Alireza; Razaghi, Reza; Navidbakhsh, Mahdi; Sera, Toshihiro; Kudo, Susumu

    2016-05-01

    In spite the fact that a very small human body surface area is comprised by the eye, its wounds due to detonation have recently been dramatically amplified. Although many efforts have been devoted to measure injury of the globe, there is still a lack of knowledge on the injury mechanism due to Primary Blast Wave (PBW). The goal of this study was to determine the stresses and deformations of the human eye components, including the cornea, aqueous, iris, ciliary body, lens, vitreous, retina, sclera, optic nerve, and muscles, attributed to PBW induced by trinitrotoluene (TNT) explosion via a Lagrangian-Eulerian computational coupling model. Magnetic Resonance Imaging (MRI) was employed to establish a Finite Element (FE) model of the human eye according to a normal human eye. The solid components of the eye were modelled as Lagrangian mesh, while an explosive TNT, air domain, and aqueous were modelled using Arbitrary Lagrangian-Eulerian (ALE) mesh. Nonlinear dynamic FE simulations were accomplished using the explicit FE code, namely LS-DYNA. In order to simulate the blast wave generation, propagation, and interaction with the eye, the ALE formulation with Jones-Wilkins-Lee (JWL) equation defining the explosive material were employed. The results revealed a peak stress of 135.70kPa brought about by detonation upsurge on the cornea at the distance of 25cm. The highest von Mises stresses were observed on the sclera (267.3kPa), whereas the lowest one was seen on the vitreous body (0.002kPa). The results also showed a relatively high resultant displacement for the macula as well as a high variation for the radius of curvature for the cornea and lens, which can result in both macular holes, optic nerve damage and, consequently, vision loss. These results may have implications not only for understanding the value of stresses and strains in the human eye components but also giving an outlook about the process of PBW triggers damage to the eye. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. Endogenous technological and population change under increasing water scarcity

    NASA Astrophysics Data System (ADS)

    Pande, S.; Ertsen, M.; Sivapalan, M.

    2014-08-01

    Ancient civilizations may have dispersed or collapsed under extreme dry conditions. There are indications that the same may hold for modern societies. However, hydroclimatic change cannot be the sole predictor of the fate of contemporary societies in water-scarce regions. This paper focuses on technological change as a factor that may ameliorate the effects of increasing water scarcity and as such counter the effects of hydroclimatic changes. We study the role of technological change on the dynamics of coupled human-water systems, and model technological change as an endogenous process that depends on many factors intrinsic to coupled human-water dynamics. We do not treat technology as an exogenous random sequence of events, but assume that it results from societal actions. While the proposed model is a rather simple model of a coupled human-water system, it is shown to be capable of replicating patterns of technological, population, production and consumption per capita changes. The model demonstrates that technological change may indeed ameliorate the effects of increasing water scarcity, but typically it does so only to a certain extent. In general we find that endogenous technology change under increasing water scarcity helps to delay the peak of population size before it inevitably starts to decline. We also analyze the case when water remains constant over time and find that co-evolutionary trajectories can never grow at a constant rate; rather the rate itself grows with time. Thus our model does not predict a co-evolutionary trajectory of a socio-hydrological system where technological innovation harmoniously provides for a growing population. It allows either for an explosion or an eventual dispersal of population. The latter occurs only under increasing water scarcity. As a result, we draw the conclusion that declining consumption per capita despite technological advancement and increase in aggregate production may serve as a useful predictor of upcoming decline in contemporary societies in water-scarce basins.

  14. Range Systems Simulation for the NASA Shuttle: Emphasis on Disaster and Prevention Management During Lift-Off

    NASA Technical Reports Server (NTRS)

    Rabelo, Lisa; Sepulveda, Jose; Moraga, Reinaldo; Compton, Jeppie; Turner, Robert

    2005-01-01

    This article describes a decision-making system composed of a number of safety and environmental models for the launch phase of a NASA Space Shuttle mission. The components of this distributed simulation environment represent the different systems that must collaborate to establish the Expectation of Casualties (E(sub c)) caused by a failed Space Shuttle launch and subsequent explosion (accidental or instructed) of the spacecraft shortly after liftoff. This decision-making tool employs Space Shuttle reliability models, trajectory models, a blast model, weather dissemination systems, population models, amount and type of toxicants, gas dispersion models, human response functions to toxicants, and a geographical information system. Since one of the important features of this proposed simulation environment is to measure blast, toxic, and debris effects, the clear benefits is that it can help safety managers not only estimate the population at risk, but also to help plan evacuations, make sheltering decisions, establish the resources required to provide aid and comfort, and mitigate damages in case of a disaster.

  15. Legendary Mount Vesuvius is subject of intensive volcanological study

    NASA Astrophysics Data System (ADS)

    Spera, Frank

    The Roman population centers of Pompeii and Herculaneum (circa 15,000 inhabitants) were destroyed when Mount Vesuvius erupted in 79 A.D. after centuries of repose. Many times since then its eruptions have claimed human lives; basaltic lava flows from an eruption in 1631 killed 3,000. Vesuvius' location, near the heart of the Roman empire—a center of learning in the ancient world—led it to become the site ofsome of the earliest volcanological studies on record.In letters to Tacitus, Pliny the Younger documented the sequence of events of the 79 A.D. plinian eruption. Geophysical studies of volcanoes were pioneered by Italian volcanologists who installed seismographs in an observatory on the flanks of Vesuvius to study volcano seismology and to forecast and monitor eruptions early this century. It is easy to understand why interest in Vesuvius has been so keen: it is accessible, persistently active, and a large population resides nearby. Today, around 1 million people live within the shadow of this potentially explosive and dangerous volcano.

  16. Raman detection of improvised explosive device (IED) material fabricated using drop-on-demand inkjet technology on several real world surfaces

    NASA Astrophysics Data System (ADS)

    Farrell, Mikella E.; Holthoff, Ellen L.; Pellegrino, Paul M.

    2015-05-01

    The requirement to detect hazardous materials (i.e., chemical, biological, and explosive) on a host of materials has led to the development of hazard detection systems. These new technologies and their capabilities could have immediate uses for the US military, national security agencies, and environmental response teams in efforts to keep people secure and safe. In particular, due to the increasing use by terrorists, the detection of common explosives and improvised explosive device (IED) materials have motivated research efforts toward detecting trace (i.e., particle level) quantities on multiple commonly encountered surfaces (e.g., textiles, metals, plastics, natural products, and even people). Non-destructive detection techniques can detect trace quantities of explosive materials; however, it can be challenging in the presence of a complex chemical background. One spectroscopic technique gaining increased attention for detection is Raman. One popular explosive precursor material is ammonium nitrate (AN). The material AN has many agricultural applications, however it can also be used in the fabrication of IEDs or homemade explosives (HMEs). In this paper, known amounts of AN will be deposited using an inkjet printer into several different common material surfaces (e.g., wood, human hair, textiles, metals, plastics). The materials are characterized with microscope images and by collecting Raman spectral data. In this report the detection and identification of AN will be demonstrated.

  17. Tempo and mode of genomic mutations unveil human evolutionary history.

    PubMed

    Hara, Yuichiro

    2015-01-01

    Mutations that have occurred in human genomes provide insight into various aspects of evolutionary history such as speciation events and degrees of natural selection. Comparing genome sequences between human and great apes or among humans is a feasible approach for inferring human evolutionary history. Recent advances in high-throughput or so-called 'next-generation' DNA sequencing technologies have enabled the sequencing of thousands of individual human genomes, as well as a variety of reference genomes of hominids, many of which are publicly available. These sequence data can help to unveil the detailed demographic history of the lineage leading to humans as well as the explosion of modern human population size in the last several thousand years. In addition, high-throughput sequencing illustrates the tempo and mode of de novo mutations, which are producing human genetic variation at this moment. Pedigree-based human genome sequencing has shown that mutation rates vary significantly across the human genome. These studies have also provided an improved timescale of human evolution, because the mutation rate estimated from pedigree analysis is half that estimated from traditional analyses based on molecular phylogeny. Because of the dramatic reduction in sequencing cost, sequencing on-demand samples designed for specific studies is now also becoming popular. To produce data of sufficient quality to meet the requirements of the study, it is necessary to set an explicit sequencing plan that includes the choice of sample collection methods, sequencing platforms, and number of sequence reads.

  18. Pair-instability supernovae of fast rotating stars

    NASA Astrophysics Data System (ADS)

    Chen, Ke-Jung

    2015-01-01

    We present 2D simulations of pair-instability supernovae considering rapid rotation during their explosion phases. Recent studies of the Population III (Pop III) star formation suggested that these stars could be born with a mass scale about 100 M⊙ and with a strong rotation. Based on stellar evolution models, these massive Pop III stars might have died as highly energetic pair-instability supernovae. We perform 2D calculations to investigate the impact of rotation on pair-instability supernovae. Our results suggest that rotation leads to an aspherical explosion due to an anisotropic collapse. If the first stars have a 50% of keplerian rotational rate of the oxygen core before their pair-instability explosions, the overall 56Ni production can be significantly reduced by about two orders of magnitude. An extreme case of 100% keplerian rotational rate shows an interesting feature of fluid instabilities along the equatorial plane caused by non-synchronized and non-isotropic ignitions of explosions, so that the shocks run into the in-falling gas and generate the Richtmyer-Meshkov instability.

  19. Characterizing the X-ray Emission in Small Magellanic Cloud Supernova Remnants

    NASA Astrophysics Data System (ADS)

    Man, Nicole; Auchettl, Katie; Lopez, Laura

    2018-01-01

    The Small Magellanic Cloud is a close, metal-poor galaxy with active star formation, and it has a diverse population of 24 supernova remnants (SNRs) that have been identified at several wavelengths. Past work has characterized the X-ray emission in these sources separately and aimed to constrain their explosive origins from observations with Chandra and XMM-Newton. Three SNRs have possible evidence for Type Ia explosions based on strong Fe-L emission in their X-ray spectra, although the environments and intermediate-mass element abundances are more consistent with those of core-collapse SNe. In this poster, we analyze the archival Chandra and XMM-Newton observations of the SMC SNR sample, and we model the sources' X-ray spectra in a systematic way to derive the plasma properties and to constrain the nature of the explosions. In one SNR, we note the presence of an X-ray binary near the source's geometric center, suggesting the compact object was produced in the SN explosion. As one of only three SNRs known in the Local Group to host a binary system, this source is worthy of follow-up investigations to probe explosions of massive stars in binary systems.

  20. The Infantry Squad: Decisive Force Now and in the Future

    DTIC Science & Technology

    2012-01-01

    robotic improvements. ●A design that includes the human dimension as a foundation. In the Near Future The vignette that follows describes how the...view the …the truth is, the network needs to be available at the individual soldier level. Robots such as TALON allow warfighters to clear routes...quickly without having to wait for explosive ordnance dis- posal teams. Here a TALON robot inspects a suspected improvised explosive device. (P ho

  1. Tunable generation and adsorption of energetic compounds in the vapor phase at trace levels: a tool for testing and developing sensitive and selective substrates for explosive detection.

    PubMed

    Bonnot, Karine; Bernhardt, Pierre; Hassler, Dominique; Baras, Christian; Comet, Marc; Keller, Valérie; Spitzer, Denis

    2010-04-15

    Among various methods for landmine detection, as well as soil and water pollution monitoring, the detection of explosive compounds in air is becoming an important and inevitable challenge for homeland security applications, due to the threatening increase in terrorist explosive bombs used against civil populations. However, in the last case, there is a crucial need for the detection of vapor phase traces or subtraces (in the ppt range or even lower). A novel and innovative generator for explosive trace vapors was designed and developed. It allowed the generation of theoretical concentrations as low as 0.24 ppq for hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in air according to Clapeyron equations. The accurate generation of explosive concentrations at subppt levels was verified for RDX and 2,4,6-trinitrotoluene (TNT) using a gas chromatograph coupled to an electron capture detector (GC-ECD). First, sensing material experiments were conducted on a nanostructured tungsten oxide. The sensing efficiency of this material determined as its adsorption capacity toward 54 ppb RDX was calculated to be five times higher than the sensing efficiency of a 54 ppb TNT vapor. The material sensing efficiency showed no dependence on the mass of material used. The results showed that the device allowed the calibration and discrimination between materials for highly sensitive and accurate sensing detection in air of low vapor pressure explosives such as TNT or RDX at subppb levels. The designed device and method showed promising features for nanosensing applications in the field of ultratrace explosive detection. The current perspectives are to decrease the testing scale and the detection levels to ppt or subppt concentration of explosives in air.

  2. Rapid Loss of Andean Alpine Glaciers: A Reflection on Cotopaxi´s Long-Distance Historical Lahars and Future Lahar Scenarios

    NASA Astrophysics Data System (ADS)

    Mothes, P. A.; Hall, M. L.; Samaniego, P.; Francou, B.; Castro, M.; Hidalgo, X.

    2007-05-01

    Andean alpine glaciers are in rapid retreat, as witnessed by actual measurements, comparative imagery and popular memory. Overall glacier losses will diminish future water availability for human consumption as well as for lahar generation, the product of mixing incandescent eruptive materials with glacial ice and snow. The field study and modeling of long-distance historical lahars from Cotopaxi volcano, Ecuador has shown them to be some of the most voluminous and longest reported. Based on back calculations, peak discharges were commonly between 45,000-60,000 m3/sec, velocities reached 70 km/hr, and run outs attained 325 km. The last "super" debris flow was produced at Cotopaxi in 1877. Observations made after the 1877 eruption reported that the glacier had suffered about 10 meters of ice stripped off the top and the incision of deep gullies from melting and erosion by the scoria block-rich pyroclastic flows. Average reductions of 45% and 60%, respectively, of the area and volume of Cotopaxi´s 19 alpine glaciers during the last 30 years have left an ice cap of only 13 km2 and a volume of 0.60 km3. Descriptions by astute 18th and 19th century observers lead us to conclude that Cotopaxi glaciers were much more robust then, surpassing a total area of about 30 km2, a fact which contributed to generating large volume lahars and high discharges, during the waning "Little Ice Age". If an eruption similar to that of 1877 occurs at Cotopaxi in the future, reduced glacier sizes and the glaciers´ preferential distribution upon the cone will likely attenuate volcano-ice interactions and will lower the probability of "super" lahars being produced during eruptive periods. However, in the last 2000 years of eruptive activity, explosive eruptions display a large size span-- from weakly explosive events (VEI= 2) to highly explosive eruptive cycles (VEI= 4-5). Given the uncertainty of the size of the next explosive eruption of Cotopaxi, several scenarios for lahar generation must be envisioned, which include the magnitude of the explosive event as well as the retreat of the glacier. These scenarios all have implications for the populations living in adjacent valleys, where future lahars may pass.

  3. 40 CFR 267.56 - What are the required emergency procedures for the emergency coordinator?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., and, if necessary, by chemical analysis. (2) Assess possible hazards to human health or the... explosion which could threaten human health, or the environment, outside the facility, he must report his...) The extent of injuries, if any. (vi) The possible hazards to human health or the environment outside...

  4. Resolving the Formation of Protogalaxies. 3; Feedback from the First Stars

    NASA Technical Reports Server (NTRS)

    Wise, John H.; Abel, Tom

    2008-01-01

    The first stars form in dark matter halos of masses 106 M as suggested by an increasing number of numerical simulations. Radiation feedback from these stars expels most of the gas from the shallow potential well of their surrounding dark matter halos.We use cosmological adaptive mesh refinement simulations that include self-consistent Population III star formation and feedback to examine the properties of assembling early dwarf galaxies. Accurate radiative transport is modeled with adaptive ray tracing. We include supernova explosions and follow the metal enrichment of the intergalactic medium. The calculations focus on the formation of several dwarf galaxies and their progenitors. In these halos, baryon fractions in 10(exp 8) Stelar Mass halos decrease by a factor of 2 with stellar feedback and by a factor of 3 with supernova explosions.We find that radiation feedback and supernova explosions increase gaseous spin parameters up to a factor of 4 and vary with time. Stellar feedback, supernova explosions, and H2 cooling create a complex, multiphase interstellar medium whose densities and temperatures can span up to 6 orders of magnitude at a given radius. The pair-instability supernovae of Population III stars alone enrich the halos with virial temperatures of 10(exp 4) K to approximately 10(exp -3) of solar metallicity.We find that 40% of the heavy elements resides in the intergalactic medium (IGM) at the end of our calculations. The highest metallicity gas exists in supernova remnants and very dilute regions of the IGM.

  5. Improved TNT detoxification by starch addition in a nitrogen-fixing Methylophilus-dominant aerobic microbial consortium.

    PubMed

    Khan, Muhammad Imran; Lee, Jaejin; Yoo, Keunje; Kim, Seonghoon; Park, Joonhong

    2015-12-30

    In this study, a novel aerobic microbial consortium for the complete detoxification of 2,4,6-trinitrotoluene (TNT) was developed using starch as a slow-releasing carbon source under nitrogen-fixing conditions. Aerobic TNT biodegradation coupled with microbial growth was effectively stimulated by the co-addition of starch and TNT under nitrogen-fixing conditions. The addition of starch with TNT led to TNT mineralization via ring cleavage without accumulation of any toxic by-products, indicating improved TNT detoxification by the co-addition of starch and TNT. Pyrosequencing targeting the bacterial 16S rRNA gene suggested that Methylophilus and Pseudoxanthomonas population were significantly stimulated by the co-addition of starch and TNT and that the Methylophilus population became predominant in the consortium. Together with our previous study regarding starch-stimulated RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) degradation (Khan et al., J. Hazard. Mater. 287 (2015) 243-251), this work suggests that the co-addition of starch with a target explosive is an effective way to stimulate aerobic explosive degradation under nitrogen-fixing conditions for enhancing explosive detoxification. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. The ins and outs of terrorist bus explosions: injury profiles of on-board explosions versus explosions occurring adjacent to a bus.

    PubMed

    Golan, Ron; Soffer, Dror; Givon, Adi; Peleg, Kobi

    2014-01-01

    Terrorist explosions occurring in varying settings have been shown to lead to significantly different injury patterns among the victims, with more severe injuries generally arising in confined space attacks. Increasing numbers of terrorist attacks have been targeted at civilian buses, yet most studies focus on events in which the bomb was detonated within the bus. This study focuses on the injury patterns and hospital utilisation among casualties from explosive terrorist bus attacks with the bomb detonated either within a bus or adjacent to a bus. All patients hospitalised at six level I trauma centres and four large regional trauma centres following terrorist explosions that occurred in and adjacent to buses in Israel between November 2000 and August 2004 were reviewed. Injury severity scores (ISS) were used to assess severity. Hospital utilisation data included length of hospital stay, surgical procedures performed, and intensive care unit (ICU) admission. The study included 262 victims of 22 terrorist attacks targeted at civilian bus passengers and drivers; 171 victims were injured by an explosion within a bus (IB), and 91 were injured by an explosion adjacent to a bus (AB). Significant differences were noted between the groups, with the IB population having higher ISS scores, more primary blast injury, more urgent surgical procedures performed, and greater ICU utilisation. Both groups had percentages of nearly 20% for burn injury, had high percentages of injuries to the head/neck, and high percentages of surgical wound and burn care. Explosive terrorist attacks detonated within a bus generate more severe injuries among the casualties and require more urgent surgical and intensive level care than attacks occurring adjacent to a bus. The comparison and description of the outcomes to these terrorist attacks should aid in the preparation and response to such devastating events. Copyright © 2013 Elsevier Ltd. All rights reserved.

  7. Fatal and non-fatal injuries due to intentional explosions in Nepal, 2008-2011: analysis of surveillance data

    PubMed Central

    2013-01-01

    Background Nepal is one of the post-conflict countries affected by violence from explosive devices. We undertook this study to assess the magnitude of injuries due to intentional explosions in Nepal during 2008-2011 and to describe time trends and epidemiologic patterns for these events. Methods We analyzed surveillance data on fatal and non-fatal injuries due to intentional explosions in Nepal that occurred between 1 January 2008 and 31 December 2011. The case definition included casualties injured or killed by explosive devices knowingly activated by an individual or a group of individuals with the intent to harm, hurt or terrorize. Data were collected through media-based and active community-based surveillance. Results Analysis included 437 casualties injured or killed in 131 intentional explosion incidents. A decrease in the number of incidents and casualties between January 2008 and June 2009 was followed by a pronounced increase between July 2010 and June 2011. Eighty-four (19.2%) casualties were among females and 40 (9.2%) were among children under 18 years of age. Fifty-nine (45.3%) incidents involved one casualty, 47 (35.9%) involved 2 to 4 casualties, and 6 involved more than 10 casualties. The overall case-fatality ratio was 7.8%. The highest numbers of incidents occurred in streets or at crossroads, in victims’ homes, and in shops or markets. Incidents on buses and near stadiums claimed the highest numbers of casualties per incident. Socket, sutali, and pressure cooker bombs caused the highest numbers of incidents. Conclusions Intentional explosion incidents still pose a threat to the civilian population of Nepal. Most incidents are caused by small homemade explosive devices and occur in public places, and males aged 20 to 39 account for a plurality of casualties. Stakeholders addressing the explosive device problem in Nepal should continue to use surveillance data to plan interventions. PMID:23514664

  8. Explosives (and other threats) detection using pulsed neutron interrogation and optimized detectors

    NASA Astrophysics Data System (ADS)

    Strellis, Dan A.; Elsalim, Mashal; Gozani, Tsahi

    2011-06-01

    We have previously reported results from a human-portable system using neutron interrogation to detect contraband and explosives. We summarized our methodology for distinguishing threat materials such as narcotics, C4, and mustard gas in the myriad of backgrounds present in the maritime environment. We are expanding our mission for the Domestic Nuclear Detection Office (DNDO) to detect Special Nuclear Material (SNM) through the detection of multiple fission signatures without compromising the conventional threat detection performance. This paper covers our initial investigations into using neutrons from compact pulsed neutron generators via the d(D,n)3He or d(T,n)α reactions with energies of ~2.5 and 14 MeV, respectively, for explosives (and other threats) detection along with a variety of gamma-ray detectors. Fast neutrons and thermal neutrons (after successive collisions) can stimulate the emission of various threat detection signatures. For explosives detection, element-specific gamma-ray signatures via the (n,n'γ) inelastic scattering reaction and the (n,'γ) thermal capture reaction are detected. For SNM, delayed gamma-rays following fission can be measured with the same detector. Our initial trade-off investigations of several gamma-ray detectors types (NaI, CsI, LaBr3, HPGe) for measuring gamma-ray signatures in a pulsed neutron environment for potential application in a human-portable active interrogation system are covered in this paper.

  9. Detection of concealed explosives at stand-off distances using wide band swept millimetre waves

    NASA Astrophysics Data System (ADS)

    Andrews, David A.; Rezgui, Nacer D.; Smith, Sarah E.; Bowring, Nicholas; Southgate, Matthew; Baker, John G.

    2008-10-01

    Millimetre waves in the range 20 to 110 GHz have been used to detect the presence and thickness of dielectric materials, such as explosives, by measuring the frequency response of the return signal. Interference between the reflected signals from the front and back surfaces of the dielectric provides a characteristic frequency variation in the return signal, which may be processed to yield its optical depth [Bowring et al, Meas. Sci. Technol. 19, 024004 (2008)]. The depth resolution depends on the sweep bandwidth, which is typically 10 to 30 GHz. By using super-heterodyne detection the range of the object can also be determined, which enables a signal from a target, such as a suicide bomber to be extracted from background clutter. Using millimetre wave optics only a small area of the target is illuminated at a time, thus reducing interference from different parts of a human target. Results are presented for simulated explosive materials with water or human backing at stand-off distances. A method of data analysis that involves pattern recognition enables effective differentiation of target types.

  10. 32 CFR 179.3 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... effects on human beings, is intended for use in military operations to kill, seriously injure, or..., and emission, degradation, or breakdown elements of such ordnance or munitions. (10 U.S.C. 2710(e)(3..., to address the explosives safety, human health, or environmental risks presented by UXO, discarded...

  11. Membrane Inlet Mass Spectrometry for Homeland Security and Forensic Applications

    NASA Astrophysics Data System (ADS)

    Giannoukos, Stamatios; Brkić, Boris; Taylor, Stephen; France, Neil

    2015-02-01

    A man-portable membrane inlet mass spectrometer has been built and tested to detect and monitor characteristic odors emitted from the human body and also from threat substances. In each case, a heated membrane sampling probe was used. During human scent monitoring experiments, data were obtained for inorganic gases and volatile organic compounds emitted from human breath and sweat in a confined space. Volatile emissions were detected from the human body at low ppb concentrations. Experiments with compounds associated with narcotics, explosives, and chemical warfare agents were conducted for a range of membrane types. Test compounds included methyl benzoate (odor signature of cocaine), piperidine (precursor in clandestine phencyclidine manufacturing processes), 2-nitrotoluene (breakdown product of TNT), cyclohexanone (volatile signature of plastic explosives), dimethyl methylphosphonate (used in sarin and soman nerve agent production), and 2-chloroethyl ethyl sulfide (simulant compound for sulfur mustard gas). Gas phase calibration experiments were performed allowing sub-ppb LOD to be established. The results showed excellent linearity versus concentration and rapid membrane response times.

  12. Membrane inlet mass spectrometry for homeland security and forensic applications.

    PubMed

    Giannoukos, Stamatios; Brkić, Boris; Taylor, Stephen; France, Neil

    2015-02-01

    A man-portable membrane inlet mass spectrometer has been built and tested to detect and monitor characteristic odors emitted from the human body and also from threat substances. In each case, a heated membrane sampling probe was used. During human scent monitoring experiments, data were obtained for inorganic gases and volatile organic compounds emitted from human breath and sweat in a confined space. Volatile emissions were detected from the human body at low ppb concentrations. Experiments with compounds associated with narcotics, explosives, and chemical warfare agents were conducted for a range of membrane types. Test compounds included methyl benzoate (odor signature of cocaine), piperidine (precursor in clandestine phencyclidine manufacturing processes), 2-nitrotoluene (breakdown product of TNT), cyclohexanone (volatile signature of plastic explosives), dimethyl methylphosphonate (used in sarin and soman nerve agent production), and 2-chloroethyl ethyl sulfide (simulant compound for sulfur mustard gas). Gas phase calibration experiments were performed allowing sub-ppb LOD to be established. The results showed excellent linearity versus concentration and rapid membrane response times.

  13. It's not just about climate change - What about soils?

    USGS Publications Warehouse

    Goldhaber, Martin B.

    2010-01-01

    Vladimir Vernadsky was one of the giants of geochemistry. Considered the founder of the fi eld of biogeochemistry and a true pioneer in “whole Earth” studies, he realized by 1945 that “Man under our very eyes is becoming a mighty and ever-growing geological force.” In the intervening 65 years, his “ever-growing force” has become a tidal wave. The global population has been increasing exponentially since the beginning of the industrial revolution, and as a result has increased by nearly a factor of three between 1945, when his observation was published, and today (see fi gure). Current projections anticipate a population exceeding 9 billion by 2050. This explosive human population growth has been fueled by ancient hydrocarbons and has come with high costs. Most Earth scientists are concerned with the implications of the rapid accumulation of greenhouse gases in the atmosphere. The consequences include a climate state without polar ice, acidifying oceans, and increasingly variable water fl uxes. The rate and extent of these and many other negative climate-related impacts, and how to mitigate them, have caused a vigorous discussion on climate change that is in the news on a nearly daily basis.

  14. [Population and economics in Quintana Roo state: some considerations from recent experience].

    PubMed

    Aguilar Barajas, I

    1995-01-01

    "This article focuses on the explosive population growth in Quintana Roo [Mexico] during the last few years and its...implications [for] the local economy. First, the article briefly describes population structure, emphasizing some migratory and socioeconomic aspects. Next it considers the status sectoral and regional production structure, which [emphasize] the strong dependence on tourism and its concentration in Cancun. In the conclusions population and economic aspects entwine, providing a more comprehensive developmental perspective." (SUMMARY IN ENG) excerpt

  15. Location and detection of explosive-contaminated human fingerprints on distant targets using standoff laser-induced breakdown spectroscopy

    NASA Astrophysics Data System (ADS)

    Lucena, P.; Gaona, I.; Moros, J.; Laserna, J. J.

    2013-07-01

    Detection of explosive-contaminated human fingerprints constitutes an analytical challenge of high significance in security issues and in forensic sciences. The use of a laser-induced breakdown spectroscopy (LIBS) sensor working at 31 m distance to the target, fitted with 2D scanning capabilities and designed for capturing spectral information from laser-induced plasmas of fingerprints is presented. Distribution chemical maps based on Na and CN emissions are used to locate and detect chloratite, DNT, TNT, RDX and PETN residues that have been deposited on the surface of aluminum and glass substrates. An effectiveness of 100% on fingerprints detection, regardless the substrate scanned, is reached. Environmental factors that affect the prevalence of the fingerprint LIBS response are discussed.

  16. The Orion Bullets: New GEMS MCAO images

    NASA Astrophysics Data System (ADS)

    Ginsburg, Adam; Bally, John; Youngblood, Allison

    2013-07-01

    The Orion A molecular cloud (OMC1) is the nearest site of massive star formation at a distance of 414 pc. The BN/KL region within it contains signs of a massive explosion triggered 500 years ago by decay of a non- hierarchical multiple system of massive stars. We present observations of the OMC1 core at high spatial resolution (<0.1") in narrow-band [Fe II] 1.64um and H2 S(1) 1-0 2.12um filters. The new data reveal compact (0.1" to 0.5") knots with unique excitation and chemical properties, unveiling new details about the three-dimensional structure of the explosion. Bright H2 emission from these compact, high proper-motion knots and compact [Fe II] features are consistent with scenario proposed by Bally et al. (2011) in which they are interpreted to be high density (n > 10^8 cm^{-3}) disk fragments launched from within a few AU of a massive star by a > three-body dynamical interaction that led to the ejection of the BN objects and the formation of a compact (separation < few AU) binary, most likely radio source I. The proper motions are as high as 400 km/s, hinting at the enormous energy unleashed in the explosion. The data also unveiled a population of obscured close binary systems. This new population will allow a comparison of embedded young binary systems with the older, un-obscured, visual binary population to test models of the evolution of multiplicity statistics in the Orion Nebula Cluster.

  17. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cavanaugh, J.E.; McQuarrie, A.D.; Shumway, R.H.

    Conventional methods for discriminating between earthquakes and explosions at regional distances have concentrated on extracting specific features such as amplitude and spectral ratios from the waveforms of the P and S phases. We consider here an optimum nonparametric classification procedure derived from the classical approach to discriminating between two Gaussian processes with unequal spectra. Two robust variations based on the minimum discrimination information statistic and Renyi's entropy are also considered. We compare the optimum classification procedure with various amplitude and spectral ratio discriminants and show that its performance is superior when applied to a small population of 8 land-based earthquakesmore » and 8 mining explosions recorded in Scandinavia. Several parametric characterizations of the notion of complexity based on modeling earthquakes and explosions as autoregressive or modulated autoregressive processes are also proposed and their performance compared with the nonparametric and feature extraction approaches.« less

  18. 10 CFR 712.10 - Designation of HRP positions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... duties or has responsibility for working with, protecting, or transporting nuclear explosives, nuclear... 10 Energy 4 2012-01-01 2012-01-01 false Designation of HRP positions. 712.10 Section 712.10 Energy DEPARTMENT OF ENERGY HUMAN RELIABILITY PROGRAM Establishment of and Procedures for the Human Reliability...

  19. 10 CFR 712.10 - Designation of HRP positions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... duties or has responsibility for working with, protecting, or transporting nuclear explosives, nuclear... 10 Energy 4 2013-01-01 2013-01-01 false Designation of HRP positions. 712.10 Section 712.10 Energy DEPARTMENT OF ENERGY HUMAN RELIABILITY PROGRAM Establishment of and Procedures for the Human Reliability...

  20. 10 CFR 712.10 - Designation of HRP positions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... duties or has responsibility for working with, protecting, or transporting nuclear explosives, nuclear... 10 Energy 4 2010-01-01 2010-01-01 false Designation of HRP positions. 712.10 Section 712.10 Energy DEPARTMENT OF ENERGY HUMAN RELIABILITY PROGRAM Establishment of and Procedures for the Human Reliability...

  1. 10 CFR 712.10 - Designation of HRP positions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... duties or has responsibility for working with, protecting, or transporting nuclear explosives, nuclear... 10 Energy 4 2011-01-01 2011-01-01 false Designation of HRP positions. 712.10 Section 712.10 Energy DEPARTMENT OF ENERGY HUMAN RELIABILITY PROGRAM Establishment of and Procedures for the Human Reliability...

  2. 10 CFR 712.10 - Designation of HRP positions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... duties or has responsibility for working with, protecting, or transporting nuclear explosives, nuclear... 10 Energy 4 2014-01-01 2014-01-01 false Designation of HRP positions. 712.10 Section 712.10 Energy DEPARTMENT OF ENERGY HUMAN RELIABILITY PROGRAM Establishment of and Procedures for the Human Reliability...

  3. Ground Shock Effects from Accidental Explosions

    DTIC Science & Technology

    1976-11-01

    1,200 P0 A = V P cp 8 Horizontal Dh = Dv tannin " 1 (cp/U)] Vh = Vv tan [sin" 1 (cp/U)] \\ - \\ tanfainŕ (cp/U)] For tan sin (c /U...explosive are not included in the present analysis . This effect will limit the credibility of the direct- induced ground shock predictions, but if the... analysis . Dr. D. R. Richmond of Lovelace Foundation provided data on human shock tolerances. 26 REFERENCES 1. "Structures to Resist the Effects of

  4. High-throughput trace analysis of explosives in water by laser diode thermal desorption/atmospheric pressure chemical ionization-tandem mass spectrometry.

    PubMed

    Badjagbo, Koffi; Sauvé, Sébastien

    2012-07-03

    Harmful explosives can accumulate in natural waters in the long term during their testing, usage, storage, and dumping and can pose a health risk to humans and the environment. For the first time, attachment of small anions to neutral molecules in laser diode thermal desorption/atmospheric pressure chemical ionization was systematically investigated for the direct determination of trace nitroaromatics, nitrate esters, and nitramine explosives in water. Using ammonium chloride as an additive improved the instrument response for all the explosives tested and promoted the formation of several characteristic adduct ions. The method performs well achieving good linearity over at least 2 orders of magnitude, with coefficients of determination greater than 0.995. The resulting limits of detection are in the range of 0.009-0.092 μg/L. River water samples were successfully analyzed by the proposed method with accuracy in the range of 96-98% and a response time of 15 s, without any further pretreatment or chromatographic separation.

  5. Burn Injury and Explosions: An Australian Perspective

    PubMed Central

    Greenwood, John E.

    2009-01-01

    Objectives: Increasingly (but not exclusively), terrorist activity and the use of explosive devices have enjoyed the focus of the global media. This paper aims to bring a range of issues to attention, to highlight how burn injuries are sustained in such incidents and why burn injuries (and thus burn disasters) are so complicated to manage. Materials and Methods: The author's experience with burn injury caused during explosions and his involvement in burn disaster situations has been summarized to form the basis of the article. This has been expanded upon with discussion points which provide a strategy for planning for such events and by a broad sample of the literature. Results: Several strategies are suggested to facilitate planning for burn disasters and to illustrate to those not directly involved why forward planning is pivotal to success when these incidents occur. Conclusions: Disasters generating large numbers of burn-injured are relatively frequent. Explosive devices are widespread in their use both in military and increasingly in civilian fields. Encompassing a large range of aetiologies, geographical sites, populations, and resources; burn disaster management is difficult and planning essential. PMID:19834533

  6. [The biological effects of a nuclear explosion. Introduction of a new system on a colorimetric scale (black, grey, red, orange, yellow and white zone) to estimate the effects of fall-out on civilian populations].

    PubMed

    Nacci, G

    2002-08-01

    Following September 11 the eventuality of terrorist attacks using bags containing nuclear devices is considered possible in western cities like New York, London, Paris, Rome, Berlin, Moscow etc. However, with a modern Civil Defence programme the effects of a catastrophe of this nature can be partially limited, at least as far as Fall-out is concerned. The present paper explains the medical reasons for building anti-fall-out shelters for the larger part of western populations: from the USA to Russia. The paper also sets out a new method for classifying levels of radioactive Fall-out based on a scale of colours (black, grey, red, orange, yellow and white) whatever kind of radioactivity is involved (total gamma levels, Cesium 137 levels, Strontium 90 levels). The arrival times for fall-out in each area of the scale are fixed, whatever the energy of the explosion and the speed of the wind might be. The radioactive decay in each area of the scale, from the time of arrival of the fall-out is described with precision. Also described are the acute radiation syndrome, tumours, miscarriages and genetic diseases. A nomogram is attached for civil defence purposes showing the leeward extension of these areas, easily measurable in just a few minutes, if four parameters are known: ground zero (locality) of the explosion, the energy of the explosion, the direction of the wind and the speed of the wind.

  7. Ascertaining the impact of catastrophic events on dengue outbreak: The 2014 gas explosions in Kaohsiung, Taiwan.

    PubMed

    Hsieh, Ying-Hen

    2017-01-01

    Infectious disease outbreaks often occur in the aftermath of catastrophic events, either natural or man-made. While natural disasters such as typhoons/hurricanes, flooding and earthquakes have been known to increase the risk of infectious disease outbreak, the impact of anthropogenic disasters is less well-understood. Kaohsiung City is located in southern Taiwan, where most dengue outbreaks had occurred in the past two decades. It is also the center of petrochemical industry in Taiwan with pipelines running underneath city streets. Multiple underground gas explosions occurred in Kaohsiung in the evening of July 31, 2014 due to chemical leaks in the pipelines. The explosions caused 32 deaths, including five firefighters and two volunteer firefighters, and injured 321 persons. Historically, dengue outbreaks in southern Taiwan occurred mostly in small numbers of around 2000 cases or less, except in 2002 with over 5000 cases. However, in the months after the gas explosions, the city reported 14528 lab-confirmed dengue cases from August to December. To investigate the possible impact, if any, of the gas explosions on this record-breaking dengue outbreak, a simple mathematical model, the Richards model, is utilized to study the temporal patterns of the spread of dengue in the districts of Kaohsiung in the proximity of the explosion sites and to pinpoint the waves of infections that had occurred in each district in the aftermath of the gas explosions. The reproduction number of each wave in each district is also computed. In the aftermath of the gas explosions, early waves occurred 4-5 days (which coincides with the minimum of human intrinsic incubation period for dengue) later in districts with multiple waves. The gas explosions likely impacted the timing of the waves, but their impact on the magnitude of the 2014 outbreak remains unclear. The modeling suggests the need for public health surveillance and preparedness in the aftermath of future disasters.

  8. Ascertaining the impact of catastrophic events on dengue outbreak: The 2014 gas explosions in Kaohsiung, Taiwan

    PubMed Central

    2017-01-01

    Infectious disease outbreaks often occur in the aftermath of catastrophic events, either natural or man-made. While natural disasters such as typhoons/hurricanes, flooding and earthquakes have been known to increase the risk of infectious disease outbreak, the impact of anthropogenic disasters is less well-understood. Kaohsiung City is located in southern Taiwan, where most dengue outbreaks had occurred in the past two decades. It is also the center of petrochemical industry in Taiwan with pipelines running underneath city streets. Multiple underground gas explosions occurred in Kaohsiung in the evening of July 31, 2014 due to chemical leaks in the pipelines. The explosions caused 32 deaths, including five firefighters and two volunteer firefighters, and injured 321 persons. Historically, dengue outbreaks in southern Taiwan occurred mostly in small numbers of around 2000 cases or less, except in 2002 with over 5000 cases. However, in the months after the gas explosions, the city reported 14528 lab-confirmed dengue cases from August to December. To investigate the possible impact, if any, of the gas explosions on this record-breaking dengue outbreak, a simple mathematical model, the Richards model, is utilized to study the temporal patterns of the spread of dengue in the districts of Kaohsiung in the proximity of the explosion sites and to pinpoint the waves of infections that had occurred in each district in the aftermath of the gas explosions. The reproduction number of each wave in each district is also computed. In the aftermath of the gas explosions, early waves occurred 4–5 days (which coincides with the minimum of human intrinsic incubation period for dengue) later in districts with multiple waves. The gas explosions likely impacted the timing of the waves, but their impact on the magnitude of the 2014 outbreak remains unclear. The modeling suggests the need for public health surveillance and preparedness in the aftermath of future disasters. PMID:28520740

  9. Modeling and simulation of explosion effectiveness as a function of blast and crowd characteristics

    NASA Astrophysics Data System (ADS)

    Usmani, Zeeshan-Ul-Hassan

    Suicide bombing has become one of the most lethal and favorite modus operandi of terrorist organizations around the world. On average, there is a suicide bombing attack every six days somewhere in the world. While various attempts have been made to assess the impact of explosions on structures and military personnel, little has been done on modeling the impact of a blast wave on a crowd in civilian settings. The assessment of an explosion's effect on a crowd can lead to better management of disasters, triage of patients, locating blast victims under the debris, development of protective gear, and safe distance recommendations to reduce the casualties. The overall goal of this work is to predict the magnitude of injuries and lethality on humans from a blast-wave with various explosive and crowd characteristics, and to compare, contrast, and analyze the performance of explosive and injury models against the real-life data of suicide bombing incidents. This thesis introduces BlastSim---a physics based stationary multi-agent simulation platform to model and simulate a suicide bombing event. The agents are constrained by the physical characteristics and mechanics of the blast wave. The BlastSim is programmed to test, analyze, and validate the results of different model combinations under various conditions with different sets of parameters, such as the crowd and explosive characteristics, blockage and human shields, fragmentation and the bomber's position, in 2-dimensional and 3-dimensional environments. The suicide bombing event can be re-created for forensic analysis. The proposed model combinations show a significant performance---the Harold Brode explosive model with Catherine Lee injury model using the blockage stands out consistently to be the best with an overall cumulative accuracy of 87.6%. When comparing against actual data, overall, prediction accuracy can be increased by 71% using this model combination. The J. Clutter with Reflection explosive model using Charles Stewart injury model with blockage works best for confined-space incidents with an accuracy of 80%. Blockage in a crowd can increase the accuracy by 17% for all models. Line-of-sight with an attacker, rushing towards an exit, announcing the threat of a suicide bombing, sitting inside a vehicle or building, and standing closer to a wall or a rigid surface were found to be the most lethal choices both during and after an attack. The findings can have implications for emergency response and counter terrorism.

  10. [Pentraxin 3].

    PubMed

    Inoue, Kenji

    2011-07-01

    Pentraxin 3 (PTX3) is a called as 'brand-new protein in traditional family' because it belongs with pentraxin family included C-reactive protein(CRP) or serum protein A (SAP), but the clinical papers published explosively in clinical situation in this 3 years. Unlike CRP, PTX3 express in atherosclerotic lesion which involve macrophages, neutrophils, dendritic cells, or smooth muscle cells, predominantly. Interestingly pitavastatin suppress PTX3 gene expression mostly in human endothelial cells among more than 6000 human genes. Therefore, we expect PTX3 to be a new biomarker for inflammatory vascular disease. Recently we developed an ELISA system for the detection of human PTX3 in plasma. Using this system, we demonstrated that PTX3 predicted patients with unstable angina pectoris(UAP). But it remains unclear why levels of PTX3 are increased in patients with acute coronary syndrome (ACS). We collected blood samples directly from the site of plaque rupture in 114 subjects with ACS who underwent PCI with an aspiration catheter. In addition, we performed immunohistochemical analyses on ACS patients' aspirated-thrombi to identify the cellular populations expressing PTX3. From these results, we concluded that infiltrating neutrophils in thrombi represent a diagnostically important source of PTX3 in patients with ACS.

  11. [Demographic pressure: a factor in political instability].

    PubMed

    Tallon, F

    1991-01-01

    A review of population trends in Rwanda is presented. They include the growing pressure on available land and resources due to an increase in the numbers of people and cattle. The author finds that this pressure, combined with ethnic tensions, has created an explosive political situation. He concludes that political stability is possible only if a vigorous population policy is implemented.

  12. Analysis of current assessments and perspectives of ESR tooth dosimetry for radiation dose reconstruction of the population residing near the Semipalatinsk nuclear test site.

    PubMed

    Romanyukha, Alex; Schauer, David A; Malikov, Yurii K

    2006-02-01

    Between 1949 and 1989 the Semipalatinsk nuclear test site (SNTS), an area of 19,000 square km in northeastern Kazakhstan, was the location of over 400 nuclear test explosions with a total explosive energy of 6.6 Mt TNT (trinitrotoluene or trotyl) equivalent. It is estimated that the bulk of the radiation exposure to the population resulted from three tests, conducted in 1949, 1951, and 1953 although estimations of radiation doses received by the local population have varied significantly. Analysis of the published ESR dose reconstruction results for residents of the villages near the SNTS show that they do not correlate well with other methods of dose assessment (e.g. model dose calculation and thermo luminescence dosimetry (TLD) in bricks). The most significant difference in dose estimations was found for the population of Dolon, which was exposed as result of the first Soviet nuclear test in 1949. Published results of ESR measurements in tooth enamel are considerably lower than other dose estimations. Detailed analysis of these results is provided and a possible explanation for this discrepancy and ways to eliminate it are suggested.

  13. Long-Duration Gamma-Ray Burst Host Galaxies in Emission and Absorption

    NASA Astrophysics Data System (ADS)

    Perley, Daniel A.; Niino, Yuu; Tanvir, Nial R.; Vergani, Susanna D.; Fynbo, Johan P. U.

    2016-12-01

    The galaxy population hosting long-duration GRBs provides a means to constrain the progenitor and an opportunity to use these violent explosions to characterize the nature of the high-redshift universe. Studies of GRB host galaxies in emission reveal a population of star-forming galaxies with great diversity, spanning a wide range of masses, metallicities, and redshifts. However, as a population GRB hosts are significantly less massive and poorer in metals than the hosts of other core-collapse transients, suggesting that GRB production is only efficient at metallicities significantly below Solar. GRBs may also prefer compact galaxies, and dense and/or central regions of galaxies, more than other types of core-collapse explosion. Meanwhile, studies of hosts in absorption against the luminous GRB optical afterglow provide a unique means of unveiling properties of the ISM in even the faintest and most distant galaxies; these observations are helping to constrain the chemical evolution of galaxies and the properties of interstellar dust out to very high redshifts. New ground- and space-based instrumentation, and the accumulation of larger and more carefully-selected samples, are continually enhancing our view of the GRB host population.

  14. Invasive Lionfish (Pterois volitans): A Potential Human Health Threat for Ciguatera Fish Poisoning in Tropical Waters

    PubMed Central

    Robertson, Alison; Garcia, Ana C.; Flores Quintana, Harold A.; Smith, Tyler B.; Castillo, Bernard F.; Reale-Munroe, Kynoch; Gulli, Joseph A.; Olsen, David A.; Hooe-Rollman, Jennifer I.; Jester, Edward L. E.; Klimek, Brian J.; Plakas, Steven M.

    2013-01-01

    Invasive Indo-Pacific lionfish (Pterois volitans) have rapidly expanded in the Western Atlantic over the past decade and have had a significant negative impact on reef fish biodiversity, habitat, and community structure, with lionfish out-competing native predators for resources. In an effort to reduce this population explosion, lionfish have been promoted for human consumption in the greater Caribbean region. This study examined whether the geographical expansion of the lionfish into a known ciguatera-endemic region can pose a human health threat for ciguatera fish poisoning (CFP). More than 180 lionfish were collected from waters surrounding the US Virgin Islands throughout 2010 and 2011. Ciguatoxin testing included an in vitro neuroblastoma cytotoxicity assay for composite toxicity assessment of sodium-channel toxins combined with confirmatory liquid chromatography tandem mass spectrometry. A 12% prevalence rate of ciguatoxic lionfish exceeding the FDA guidance level of 0.1 µg/kg C-CTX-1 equivalents was identified in fish from the U.S. Virgin Islands, highlighting a potential consumption risk in this region. This study presents the first evidence that the invasive lionfish, pose a direct human health risk for CFP and highlights the need for awareness and research on this food safety hazard in known endemic areas. PMID:24378919

  15. Invasive lionfish (Pterois volitans): a potential human health threat for ciguatera fish poisoning in tropical waters.

    PubMed

    Robertson, Alison; Garcia, Ana C; Quintana, Harold A Flores; Smith, Tyler B; Castillo, Bernard F; Reale-Munroe, Kynoch; Gulli, Joseph A; Olsen, David A; Hooe-Rollman, Jennifer I; Jester, Edward L E; Klimek, Brian J; Plakas, Steven M

    2013-12-27

    Invasive Indo-Pacific lionfish (Pterois volitans) have rapidly expanded in the Western Atlantic over the past decade and have had a significant negative impact on reef fish biodiversity, habitat, and community structure, with lionfish out-competing native predators for resources. In an effort to reduce this population explosion, lionfish have been promoted for human consumption in the greater Caribbean region. This study examined whether the geographical expansion of the lionfish into a known ciguatera-endemic region can pose a human health threat for ciguatera fish poisoning (CFP). More than 180 lionfish were collected from waters surrounding the US Virgin Islands throughout 2010 and 2011. Ciguatoxin testing included an in vitro neuroblastoma cytotoxicity assay for composite toxicity assessment of sodium-channel toxins combined with confirmatory liquid chromatography tandem mass spectrometry. A 12% prevalence rate of ciguatoxic lionfish exceeding the FDA guidance level of 0.1 µg/kg C-CTX-1 equivalents was identified in fish from the U.S. Virgin Islands, highlighting a potential consumption risk in this region. This study presents the first evidence that the invasive lionfish, pose a direct human health risk for CFP and highlights the need for awareness and research on this food safety hazard in known endemic areas.

  16. Identifying isotropic events using a regional moment tensor inversion

    DOE PAGES

    Ford, Sean R.; Dreger, Douglas S.; Walter, William R.

    2009-01-17

    We calculate the deviatoric and isotropic source components for 17 explosions at the Nevada Test Site, as well as 12 earthquakes and 3 collapses in the surrounding region of the western United States, using a regional time domain full waveform inversion for the complete moment tensor. The events separate into specific populations according to their deviation from a pure double-couple and ratio of isotropic to deviatoric energy. The separation allows for anomalous event identification and discrimination between explosions, earthquakes, and collapses. Confidence regions of the model parameters are estimated from the data misfit by assuming normally distributed parameter values. Wemore » investigate the sensitivity of the resolved parameters of an explosion to imperfect Earth models, inaccurate event depths, and data with low signal-to-noise ratio (SNR) assuming a reasonable azimuthal distribution of stations. In the band of interest (0.02–0.10 Hz) the source-type calculated from complete moment tensor inversion is insensitive to velocity model perturbations that cause less than a half-cycle shift (<5 s) in arrival time error if shifting of the waveforms is allowed. The explosion source-type is insensitive to an incorrect depth assumption (for a true depth of 1 km), and the goodness of fit of the inversion result cannot be used to resolve the true depth of the explosion. Noise degrades the explosive character of the result, and a good fit and accurate result are obtained when the signal-to-noise ratio is greater than 5. We assess the depth and frequency dependence upon the resolved explosive moment. As the depth decreases from 1 km to 200 m, the isotropic moment is no longer accurately resolved and is in error between 50 and 200%. Furthermore, even at the most shallow depth the resultant moment tensor is dominated by the explosive component when the data have a good SNR.« less

  17. An Era of Global Scarcity

    ERIC Educational Resources Information Center

    Abelson, Philip H.

    1973-01-01

    Discusses problems facing the world with increasing demands for food, energy, raw materials and goods, and at the same time confronted with a population explosion. Views the future of the United States optimistically when compared to less developed countries. (JR)

  18. Application of the FTA and ETA Method for Gas Hazard Identification for the Performance of Safety Systems in the Industrial Department

    NASA Astrophysics Data System (ADS)

    Ignac-Nowicka, Jolanta

    2018-03-01

    The paper analyzes the conditions of safe use of industrial gas systems and factors influencing gas hazards. Typical gas installation and its basic features have been characterized. The results of gas threat analysis in an industrial enterprise using FTA error tree method and ETA event tree method are presented. Compares selected methods of identifying hazards gas industry with respect to the scope of their use. The paper presents an analysis of two exemplary hazards: an industrial gas catastrophe (FTA) and an explosive gas explosion (ETA). In both cases, technical risks and human errors (human factor) were taken into account. The cause-effect relationships of hazards and their causes are presented in the form of diagrams in the drawings.

  19. Near Earth asteroid orbit perturbation and fragmentation

    NASA Technical Reports Server (NTRS)

    Ahrens, Thomas J.; Harris, Alan W.

    1992-01-01

    Collisions by near earth asteroids or the nuclei of comets pose varying levels of threat to man. A relatively small object, approximately 100 meter diameter, which might be found on an impact trajectory with a populated region of the Earth, could potentially be diverted from an Earth impacting trajectory by mass driver rocket systems. For larger bodies, such systems would appear to be beyond current technology. For any size object, nuclear explosions appear to be more efficient, using either the prompt blow-off from neutron radiation, the impulse from ejecta of near-surface explosion for deflection, or as a fragmenting charge. Practical deflections of bodies with diameters of 0.1, 1, and 10 km require interception, years to decades prior to earth encounter, with explosions a few kilotons, megatons, or gigatons, respectively, of equivalent TNT energy to achieve orbital velocity changes or destruction to a level where fragments are dispersed to harmless spatial densities.

  20. Contribution of explosion and future collision fragments to the orbital debris environment

    NASA Technical Reports Server (NTRS)

    Su, S.-Y.; Kessler, D. J.

    1985-01-01

    The time evolution of the near-earth man-made orbital debris environment modeled by numerical simulation is presented in this paper. The model starts with a data base of orbital debris objects which are tracked by the NORAD ground radar system. The current untrackable small objects are assumed to result from explosions and are predicted from data collected from a ground explosion experiment. Future collisions between earth orbiting objects are handled by the Monte Carlo method to simulate the range of collision possibilities that may occur in the real world. The collision fragmentation process between debris objects is calculated using an empirical formula derived from a laboratory spacecraft impact experiment to obtain the number versus size distribution of the newly generated debris population. The evolution of the future space debris environment is compared with the natural meteoroid background for the relative spacecraft penetration hazard.

  1. Internet Based Simulations of Debris Dispersion of Shuttle Launch

    NASA Technical Reports Server (NTRS)

    Bardina, Jorge; Thirumalainambi, Rajkumar

    2004-01-01

    The debris dispersion model (which dispersion model?) is so heterogeneous and interrelated with various factors, 3D graphics combined with physical models are useful in understanding the complexity of launch and range operations. Modeling and simulation in this area mainly focuses on orbital dynamics and range safety concepts, including destruct limits, telemetry and tracking, and population risk. Particle explosion modeling is the process of simulating an explosion by breaking the rocket into many pieces. The particles are scattered throughout their motion using the laws of physics eventually coming to rest. The size of the foot print explains the type of explosion and distribution of the particles. The shuttle launch and range operations in this paper are discussed based on the operations of the Kennedy Space Center, Florida, USA. Java 3D graphics provides geometric and visual content with suitable modeling behaviors of Shuttle launches.

  2. UV-B Radiation Contributes to Amphibian Population Declines

    NASA Astrophysics Data System (ADS)

    Blaustein, Andrew

    2007-05-01

    UV-B (280-315 nm) radiation is the most significant biologically damaging radiation at the terrestrial surface. At the organismal level, UV-B radiation can slow growth rates, cause immune dysfunction and result in sublethal damage. UV-B radiation can lead to mutations and cell death. Over evolutionary time, UV radiation has been an important stressor on living organisms. Natural events, including impacts from comets and asteroids, volcanic activity, supernova explosions and solar flares, can cause large-scale ozone depletion with accompanying increases in UV radiation. However, these natural events are transient. Moreover, the amount of ozone damage due to natural events depends upon a number of variables, including the magnitude of the event. This is different from modern-day human-induced production of chlorofluorocarbons (CFCs) and other chemicals that deplete stratospheric ozone continuously, resulting in long-term increases in UV-B radiation at the surface of the earth. We will briefly review the effects of UV-B exposure in one group of aquatic organisms_amphibians. UV-B has been implicated as a possible factor contributing to global declines and range reductions in amphibian populations.

  3. The contribution of interindividual factors to variability of response in transcranial direct current stimulation studies

    PubMed Central

    Li, Lucia M.; Uehara, Kazumasa; Hanakawa, Takashi

    2015-01-01

    There has been an explosion of research using transcranial direct current stimulation (tDCS) for investigating and modulating human cognitive and motor function in healthy populations. It has also been used in many studies seeking to improve deficits in disease populations. With the slew of studies reporting “promising results” for everything from motor recovery after stroke to boosting memory function, one could be easily seduced by the idea of tDCS being the next panacea for all neurological ills. However, huge variability exists in the reported effects of tDCS, with great variability in the effect sizes and even contradictory results reported. In this review, we consider the interindividual factors that may contribute to this variability. In particular, we discuss the importance of baseline neuronal state and features, anatomy, age and the inherent variability in the injured brain. We additionally consider how interindividual variability affects the results of motor-evoked potential (MEP) testing with transcranial magnetic stimulation (TMS), which, in turn, can lead to apparent variability in response to tDCS in motor studies. PMID:26029052

  4. Potential for portal detection of human chemical and biological contamination

    NASA Astrophysics Data System (ADS)

    Settles, Gary S.; McGann, William J.

    2001-08-01

    The walk-through metal-detection portal is a paradigm of non-intrusive passenger screening in aviation security. Modern explosive detection portals based on this paradigm will soon appear in airports. This paper suggests that the airborne trace detection technology developed for that purpose can also be adapted to human chemical and biological contamination. The waste heat of the human body produces a rising warm-air sheath of 50-80 liters/sec known as the human thermal plume. Contained within this plume are hundreds of bioeffluents from perspiration and breath, and millions of skin flakes. Since early medicine, the airborne human scent was used in the diagnosis of disease. Recent examples also include toxicity and substance abuse, but this approach has never been quantified. The appearance of new bioeffluents or subtle changes in the steady-state may signal the onset of a chemical/biological attack. Portal sampling of the human thermal plume is suggested, followed by a pre-concentration step and the detection of the attacking agent or the early human response. The ability to detect nanogram levels of explosive trace contamination this way was already demonstrated. Key advantages of the portal approach are its rapidity and non-intrusiveness, and the advantage that it does not require the traditional bodily fluid or tissue sampling.

  5. Extinction and recolonization of local populations on a growing shield volcano.

    PubMed

    Carson, H L; Lockwood, J P; Craddock, E M

    1990-09-01

    Volcanic action has resulted in the burial of the surfaces of Mauna Loa and Kilauea, Hawaii, by new lava flows at rates as high as 90% per 1000 years. Local populations of organisms on such volcanoes are continually being exterminated; survival of the species requires colonization of younger flows. Certain populations of the endemic Hawaiian species Drosophila silvestris exemplify such events in microcosm. Local populations at the base of an altitudinal cline were destroyed by two explosive eruptions within the last 2100 years. Natural recolonization restored the cline except for one young population that is genetically discordant with altitude.

  6. Parameterization of strombolian explosions: constraint from simultaneous physical and geophysical measurements (Invited)

    NASA Astrophysics Data System (ADS)

    gurioli, L.; Harris, A. J.

    2013-12-01

    Strombolian activity is the most common type of explosive eruption (by frequency) experienced by Earth's volcanoes. It is commonly viewed as consisting of a succession of short discrete explosions where fragments of incandescent magma are ejected a few tens to hundreds meters into the air. This kind of activity is generally restricted to basaltic or basaltic-andesitic magmas because these systems have the sufficiently low viscosities so as to allow gas coalescence and decoupled slug ascent. Mercalli (1907) proposed one of the first formal classifications of explosive activity based on the character of the erupted products and descriptions of case-type eruptions. Later, Walker (1973) devised a classification based on grain size and dispersion, within which strombolian explosions formed the low-to-middle end of the classification. Other classifications have categorized strombolian activity on the basis of erupted magnitude and/or intensity, such as Newhall and Self's (1982) Volcanic Explosivity Index (VEI). Classification can also be made on the basis of explosion mechanism, where strombolian eruptions have become associated with bursting of large gas bubbles, as opposed to release of locked in bubble populations in rapidly ascending magma that feed sustained fountains. Finally, strombolian eruptions can be defined on the basis of geophysical metrics for the explosion source and plume ascent dynamics. Recently, the volcanology community has begun to discuss the difficulty of actually placing strombolian explosions within the compartments defined by each scheme. New sampling strategies in active strombolian volcanic fields have allowed us to parameterize these mildly explosive events both physically and geophysically. Our data show that individual 'normal' and "major" explosions at Stromboli are extremely small, meaning that the classical deposit-based classification thresholds need to be reduced, or a new category defined, if the 'strombolian' eruption style at Stromboli, and other volcanoes like it, are to plot in the strombolian fields of deposit-based classifications. We also quenched a number of bombs soon explosion at Stromboli. This enabled us to quantify the degassing history and rheology of the magma(s) resident in the shallow, near-surface, system. The different textural facies observed in these bombs showed that fresh magma, mingled with partially or completely degassed, oxidized, re-crystallized, evolved and high viscosity magma, was ejected. The degassed magma appears to sit at the top of the conduit, playing only a passive role in the explosive process. Our best model, is that the degassed, oxidized magma forms a plug, or rheologically defined layer, at the top of the conduit, through which the fresh magma bursts. Integration of geophysical measurements with sample analyses, indicates that popular (bubble-bursting) models may not fit this case, thus also changeling the model-based definition of this eruption type.

  7. REGIONAL SEISMIC CHEMICAL AND NUCLEAR EXPLOSION DISCRIMINATION: WESTERN U.S. EXAMPLES

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Walter, W R; Taylor, S R; Matzel, E

    2006-07-07

    We continue exploring methodologies to improve regional explosion discrimination using the western U.S. as a natural laboratory. The western U.S. has abundant natural seismicity, historic nuclear explosion data, and widespread mine blasts, making it a good testing ground to study the performance of regional explosion discrimination techniques. We have assembled and measured a large set of these events to systematically explore how to best optimize discrimination performance. Nuclear explosions can be discriminated from a background of earthquakes using regional phase (Pn, Pg, Sn, Lg) amplitude measures such as high frequency P/S ratios. The discrimination performance is improved if the amplitudesmore » can be corrected for source size and path length effects. We show good results are achieved using earthquakes alone to calibrate for these effects with the MDAC technique (Walter and Taylor, 2001). We show significant further improvement is then possible by combining multiple MDAC amplitude ratios using an optimized weighting technique such as Linear Discriminant Analysis (LDA). However this requires data or models for both earthquakes and explosions. In many areas of the world regional distance nuclear explosion data is lacking, but mine blast data is available. Mine explosions are often designed to fracture and/or move rock, giving them different frequency and amplitude behavior than contained chemical shots, which seismically look like nuclear tests. Here we explore discrimination performance differences between explosion types, the possible disparity in the optimization parameters that would be chosen if only chemical explosions were available and the corresponding effect of that disparity on nuclear explosion discrimination. Even after correcting for average path and site effects, regional phase ratios contain a large amount of scatter. This scatter appears to be due to variations in source properties such as depth, focal mechanism, stress drop, in the near source material properties (including emplacement conditions in the case of explosions) and in variations from the average path and site correction. Here we look at several kinds of averaging as a means to try and reduce variance in earthquake and explosion populations and better understand the factors going into a minimum variance level as a function of epicenter (see Anderson ee et al. this volume). We focus on the performance of P/S ratios over the frequency range from 1 to 16 Hz finding some improvements in discrimination as frequency increases. We also explore averaging and optimally combining P/S ratios in multiple frequency bands as a means to reduce variance. Similarly we explore the effects of azimuthally averaging both regional amplitudes and amplitude ratios over multiple stations to reduce variance. Finally we look at optimal performance as a function of magnitude and path length, as these put limits the availability of good high frequency discrimination measures.« less

  8. Trends in maar crater size and shape using the global Maar Volcano Location and Shape (MaarVLS) database

    NASA Astrophysics Data System (ADS)

    Graettinger, A. H.

    2018-05-01

    A maar crater is the top of a much larger subsurface diatreme structure produced by phreatomagmatic explosions and the size and shape of the crater reflects the growth history of that structure during an eruption. Recent experimental and geophysical research has shown that crater complexity can reflect subsurface complexity. Morphometry provides a means of characterizing a global population of maar craters in order to establish the typical size and shape of features. A global database of Quaternary maar crater planform morphometry indicates that maar craters are typically not circular and frequently have compound shapes resembling overlapping circles. Maar craters occur in volcanic fields that contain both small volume and complex volcanoes. The global perspective provided by the database shows that maars are common in many volcanic and tectonic settings producing a similar diversity of size and shape within and between volcanic fields. A few exceptional populations of maars were revealed by the database, highlighting directions of future research to improve our understanding on the geometry and spacing of subsurface explosions that produce maars. These outlying populations, such as anomalously large craters (>3000 m), chains of maars, and volcanic fields composed of mostly maar craters each represent a small portion of the database, but provide opportunities to reinvestigate fundamental questions on maar formation. Maar crater morphometry can be integrated with structural, hydrological studies to investigate lateral migration of phreatomagmatic explosion location in the subsurface. A comprehensive database of intact maar morphometry is also beneficial for the hunt for maar-diatremes on other planets.

  9. Terror explosive injuries: a comparison of children, adolescents, and adults.

    PubMed

    Jaffe, Dena H; Peleg, Kobi

    2010-01-01

    We sought to characterize injuries and outcomes from terror explosions with specific attention to children (0-10 years) and adolescents (11-15 years) compared to adults (16-45 years). Terror explosions target vulnerable populations and result in multidimensional injuries that may vary according to age group. The relative dearth of information regarding terror-related injuries among children inhibits proper preparedness and optimum management during such an event. A retrospective study was performed using data from the national Israel Trauma Registry (October 2000 to December 2005). Included were civilians and nonactive military personnel hospitalized as a result of a terror explosion. During the 5.3-year study period, 49 children (0-10 years), 65 adolescents (11-15 years), and 723 adults (16-45 years) were hospitalized from terror explosions. Children were more likely than adults to sustain severe injuries (27% vs. 12%) and traumatic brain injury (35% vs. 20%) and less likely to sustain injuries to their extremities (35% vs. 57%) or open wounds (39% vs. 59%) (P

  10. Investigating the diversity of supernovae type Iax: a MUSE and NOT spectroscopic study of their environments

    NASA Astrophysics Data System (ADS)

    Lyman, J. D.; Taddia, F.; Stritzinger, M. D.; Galbany, L.; Leloudas, G.; Anderson, J. P.; Eldridge, J. J.; James, P. A.; Krühler, T.; Levan, A. J.; Pignata, G.; Stanway, E. R.

    2018-01-01

    SN 2002cx-like Type Ia supernovae (also known as SNe Iax) represent one of the most numerous peculiar SN classes. They differ from normal SNe Ia by having fainter peak magnitudes, faster decline rates and lower photospheric velocities, displaying a wide diversity in these properties. We present both integral-field and long-slit visual-wavelength spectroscopy of the host galaxies and explosion sites of SNe Iax to provide constraints on their progenitor formation scenarios. The SN Iax explosion-site metallicity distribution is similar to that of core-collapse SNe and metal poor compared to either normal SNe Ia or SN 1991T-like events. Fainter members, speculated to form distinctly from brighter SN Iax, are found at a range of metallicities, extending to very metal poor environments. Although the SN Iax explosion-sites' ages and star formation rates are comparatively older and less intense than the distribution of star-forming regions across their host galaxies, we confirm the presence of young stellar populations (SPs) at explosion environments for most SNe Iax, expanded here to a larger sample. Ages of the young SPs (several × 107 to 108 yr) are consistent with predictions for young thermonuclear and electron-capture SN progenitors. The lack of extremely young SPs at the explosion sites disfavours very massive progenitors such as Wolf-Rayet explosions with significant fallback. We find weak ionized gas in the only SN Iax host without obvious signs of star formation. The source of the ionization remains ambiguous but appears unlikely to be mainly due to young, massive stars.

  11. 77 FR 28600 - Draft publication: Coal Dust Explosibility Meter Evaluation and Recommendations for Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-15

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention [Docket Number... Recommendations for Application Authority: 30 U.S.C. 95l. AGENCY: National Institute for Occupational Safety and Health (NIOSH) of the Centers for Disease Control and Prevention (CDC), Department of Health and Human...

  12. Raman Detection of Improvised Explosive Device (IED) Material Fabricated Using Drop-on-Demand Inkjet Technology on Several Real World Surfaces

    DTIC Science & Technology

    2015-09-01

    deposited using an inkjet printer into several different common material surfaces (e.g., wood, human hair , textiles, metals, plastics). The materials are......human hair , textiles, metals, plastics). The materials are characterized with microscope images and by collecting Raman spectral data. In this

  13. The resolved stellar populations around 12 Type IIP supernovae

    NASA Astrophysics Data System (ADS)

    Maund, Justyn R.

    2017-08-01

    Core-collapse supernovae (SNe) are found in regions associated with recent massive star formation. The stellar population observed around the location of a SN can be used as a probe of the origins of the progenitor star. We apply a Bayesian mixture model to fit isochrones to the massive star population around 12 Type IIP SNe, for which constraints on the progenitors are also available from fortuitous pre-explosion images. Using the high-resolution Hubble Space Telescope Advanced Camera for Surveys and Wide Field Camera 3, we study the massive star population found within 100 pc of each of our target SNe. For most of the SNe in our sample, we find that there are multiple age components in the surrounding stellar populations. In the cases of SNe 2003gd and 2005cs, we find that the progenitor does not come from the youngest stellar population component and, in fact, these relatively low mass progenitors (˜8 M⊙) are found in close proximity to stars as massive as 15 and 50-60 M⊙, respectively. Overall, the field extinction (Galactic and host) derived for these populations is ˜0.3 mag higher than the extinction that was generally applied in previously reported progenitor analyses. We also find evidence, in particular for SN 2004dj, for significant levels of differential extinction. Our analysis for SN 2008bk suggests a significantly lower extinction for the population than the progenitor, but the lifetime of the population and mass determined from pre-explosion images agree. Overall, assuming that the appropriate age component can be suitably identified from the multiple stellar population components present, we find that our Bayesian approach to studying resolved stellar populations can match progenitor masses determined from direct imaging to within ±3 M⊙.

  14. Population evolution in the GEO vicinity

    NASA Astrophysics Data System (ADS)

    Wegener, P.; Bendisch, J.; Krag, H.; Stabroth, S.

    The geostationary orbit is now in use for nearly 40 years. Due to the absence of major energy dissipating mechanisms, the object population in the GEO environment steadily grew during this time. In mid 2001, a total of 762 known objects permanently resided within the GEO region (GEO +/-1000 km). Additionally, two explosion events are confirmed within the geostationary ring, which further enlarge the already existing population consisting of payloads and upper stages. Recent observation results obtained by the ESA Space Debris Telescope (SDT) at Tenerife show strong indications for even more fragment clouds. Since the geostationary ring can be seen as a unique resource, which is not protected by any significant selfcleaning effect, a monitoring of the object environment in the vicinity of this orbit is mandatory. In a first step, this paper characterizes the history and current state of the GEO environment. The evolution of fresh object clouds within and out of the ring is analysed to get a better understanding of the short- and mid-term impact of explosion events as well as Solid Rocket Motor (SRM) firings on the overall population. Next to explosion prevention, the transfer of satellites to a graveyard orbit about 300 km above the geostationary altitude is agreed to be the most effective mean to preserve GEO. Although this procedure is internationally recommended, only one third of the retiring spacecraft is in fact brought to a sufficiently high orbit. Another 30% performs a re-orbiting, but is ending up in an orbit in the direct vicinity of the GEO ring or even touching or crossing it. The reason for this low performance often can be found in insufficient fuel gauging or urgent need for several more months of operation. In the future, one possibility to mitigate the population growth by remo v - i n g those spacecraft could be a dedicated vehicle transferring several large objects to the graveyard area before retiring there on its own. The number and distribution of possible candidates for such a removal is outlined. Assuming a future traffic model and different scenarios for re-orbiting and removal, the future evolution of the large object population in and near GEO can be estimated.

  15. Conduit Wall Failure as a Trigger for Transition From Strombolian to Phreatomagmatic Explosive Activity in the Cova de Paúl Crater Eruption on Santo Antão, Cape Verde Islands

    NASA Astrophysics Data System (ADS)

    Tarff, R. W.; Day, S. J.

    2011-12-01

    Episodes of hazardous phreatomagmatic explosive activity, including Surtseyan activity, occur within otherwise less dangerous effusive to mildly explosive magmatic eruptions at high-elevation vents on many oceanic island volcanoes. The water driving these explosions is sourced from freshwater aquifers within the volcanic edifices. Understanding volcanic and geophysical precursors to, and mechanisms of, the (frequently abrupt) transitions to explosive activity is required as a basis for effective warning and mitigation of the resulting hazards. Here we describe near-vent deposits around the large Cova de Paúl crater on the island of Santo Antão, Cape Verde Islands, which provide some insights into a transition from mild magmatic to violently explosive phreatomagmatic activity in one such eruption. This pre-historic but well-preserved crater formed in a single eruption that produced extensive low-temperature, lithic-rich phreatomagmatic pyroclastic flows and surge deposits; these are interbedded in proximal outcrops with airfall breccia and ash beds containing varying proportions of lithic and juvenile clasts, pointing to a series of climactic explosions within an extended period of milder explosive activity of broadly Surtseyan type. Prior to the transition to phreatomagmatic activity, the eruption had been characterized by mild Strombolian activity that produced scoria and spatter deposits of broadly tephritic composition. The Strombolian deposits contain a distinct population of strongly banded, low-vesicularity angular clasts with strongly prolate vesicles and a notably glassy appearance. These became markedly larger and more abundant just below the transition to the phreatomagmatic deposits. Comparisons of these clasts with the Strombolian scoria suggest that they are fragments of flow-banded chilled margins from the walls of the eruptive conduit. Thermal shattering of these margins to produce the angular glassy clasts may record the onset of groundwater flow into the conduit, leading to the phreatomagmatic explosive phase of the eruption. Fragmentation of the conduit wall and ingress of groundwater would likely have been accompanied by seismic swarms consisting of high-frequency fracture events and episodes of harmonic tremor, pointing to a potential geophysical signature of the onset of phreatomagmatic explosive activity in comparable future eruptions on Santo Antão and other oceanic islands.

  16. Human ecology and behavior and sexually transmitted bacterial infections.

    PubMed Central

    Holmes, K K

    1994-01-01

    The three direct determinants of the rate of spread of sexually transmitted diseases (STDs) are sexual behaviors, the mean duration of infectiousness, and the mean efficiency of sexual transmission of each STD. Underlying ecological and behavioral factors that operate through one or more of these direct determinants lie on a continuum, ranging from those most proximate back to those more remote (in time or mechanism) from the direct determinants. Most remote and least modifiable are the historical stages of economic development that even today conspicuously influence patterns of sexual behavior. Next are the distribution and changing patterns of climate, hygiene, and population density; the global population explosion and stages of the demographic transition; and ongoing changes in human physiology (e.g., menarche at younger age) and culture (e.g., later marriage). More proximate on the continuum are war, migration, and travel; and current policies for economic development and social welfare. Most recent or modifiable are technologic and commercial product development (e.g., oral contraceptives); circumcision, condom, spermicide, and contraception practices; patterns of illicit drug use that influence sexual behaviors; and the accessibility, quality, and use of STD health care. These underlying factors help explain why the curable bacterial STDs are epidemic in developing countries and why the United States is the only industrialized country that has failed to control bacterial STDs during the AIDS era. Images PMID:8146138

  17. Issues, considerations and recommendations on emergency preparedness for vulnerable population groups.

    PubMed

    Chen, Jing; Wilkinson, Diana; Richardson, Richard B; Waruszynski, Barbara

    2009-06-01

    The Workshop on Emergency Preparedness for Vulnerable Population Groups was held on 2 and 3 March 2009 in Ottawa, ON, Canada. The purpose of the workshop was to enhance communications within the emergency community response network and to identify the needs and gaps of emergency preparedness against chemical, biological, radiological, nuclear and explosives events for vulnerable population groups. The workshop was organised to enable extensive round-table discussions and provide a summary of key issues, considerations and recommendations for emergency response planners.

  18. Solar Flares and the High Energy Solar Spectroscopic Imager (HESSI)

    NASA Technical Reports Server (NTRS)

    Holman, Gordon D.; Fisher, Richard R. (Technical Monitor)

    2001-01-01

    Solar flares are the biggest explosions in the solar system. They are important both for understanding explosive events in the Universe and for their impact on human technology and communications. The satellite-based HESSI is designed to study the explosive release of energy and the acceleration of electrons, protons, and other charged particles to high energies in solar flares. HESSI produces "color" movies of the Sun in high-energy X rays and gamma rays radiated by these energetic particles. HESSI's X-ray and gamma-ray images of flares are obtained using techniques similar to those used in radio interferometry. Ground-based radio observations of the Sun provide an important complement to the HESSI observations of solar flares. I will describe the HESSI Project and the high-energy aspects of solar flares, and how these relate to radio astronomy techniques and observations.

  19. An investigation of a reticulated foam - perforated steel sheet combination as a blast mitigation structure

    NASA Astrophysics Data System (ADS)

    Nguyen, Thuy-Tien N.; Proud, William G.

    2017-01-01

    Explosions are one of the main causes of injuries during battles and conflicts, with improvised explosive devices (IEDs) becoming increasingly common. Blast waves produced from such explosions can inflict very complex injuries on human and serious damage to structures. Here, the interaction between blast waves and sandwich structures of reticulated foam and perforated sheets is studied using a shock tube. The level of mitigation for primary blast injuries of these structures are discussed in terms of pulse shape, pressure magnitude and impulse. Schlieren photography and other high-speed imaging were used to capture the form of the blast wave. The results show up to 95% mitigation in both pressure and impulse with the structures studied. The behaviors of these mitigating sandwich panels under two loadings, Mach 2.0 and Mach 2.6, are also discussed.

  20. The High-Strain Rate Loading of Structural Biological Materials

    NASA Astrophysics Data System (ADS)

    Proud, W. G.; Nguyen, T.-T. N.; Bo, C.; Butler, B. J.; Boddy, R. L.; Williams, A.; Masouros, S.; Brown, K. A.

    2015-10-01

    The human body can be subjected to violent acceleration as a result of explosion caused by military ordinance or accident. Blast waves cause injury and blunt trauma can be produced by violent impact of objects against the human body. The long-term clinical manifestations of blast injury can be significantly different in nature and extent to those suffering less aggressive insult. Similarly, the damage seen in lower limbs from those injured in explosion incidents is in general more severe than those falling from height. These phenomena increase the need for knowledge of the short- and long-term effect of transient mechanical loading to the biological structures of the human body. This paper gives an overview of some of the results of collaborative investigation into blast injury. The requirement for time-resolved data, appropriate mechanical modeling, materials characterization and biological effects is presented. The use of a range of loading platforms, universal testing machines, drop weights, Hopkinson bars, and bespoke traumatic injury simulators are given.

  1. Detection of contraband concealed on the body using x-ray imaging

    NASA Astrophysics Data System (ADS)

    Smith, Gerald J.

    1997-01-01

    In an effort to avoid detection, smugglers and terrorists are increasingly using the body as a vehicle for transporting illicit drugs, weapons, and explosives. This trend illustrates the natural tendency of traffickers to seek the path of least resistance, as improved interdiction technology and operational effectiveness have been brought to bear on other trafficking avenues such as luggage, cargo, and parcels. In response, improved technology for human inspection is being developed using a variety of techniques. ASE's BodySearch X-ray Inspection Systems uses backscatter x-ray imaging of the human body to quickly, safely, and effectively screen for drugs, weapons, and explosives concealed on the body. This paper reviews the law enforcement and social issues involved in human inspections, and briefly describes the ASE BodySearch systems. Operator training, x-ray image interpretation, and maximizing systems effectiveness are also discussed. Finally, data collected from operation of the BodySearch system in the field is presented, and new law enforcement initiatives which have come about due to recent events are reviewed.

  2. Disease-induced resource constraints can trigger explosive epidemics.

    PubMed

    Böttcher, L; Woolley-Meza, O; Araújo, N A M; Herrmann, H J; Helbing, D

    2015-11-16

    Advances in mathematical epidemiology have led to a better understanding of the risks posed by epidemic spreading and informed strategies to contain disease spread. However, a challenge that has been overlooked is that, as a disease becomes more prevalent, it can limit the availability of the capital needed to effectively treat those who have fallen ill. Here we use a simple mathematical model to gain insight into the dynamics of an epidemic when the recovery of sick individuals depends on the availability of healing resources that are generated by the healthy population. We find that epidemics spiral out of control into "explosive" spread if the cost of recovery is above a critical cost. This can occur even when the disease would die out without the resource constraint. The onset of explosive epidemics is very sudden, exhibiting a discontinuous transition under very general assumptions. We find analytical expressions for the critical cost and the size of the explosive jump in infection levels in terms of the parameters that characterize the spreading process. Our model and results apply beyond epidemics to contagion dynamics that self-induce constraints on recovery, thereby amplifying the spreading process.

  3. OPERATION CASTLE - Project 4.1 Addendum. Report of the Scientific Director, Exposure of Marshall Islanders and American Military Personnel to Fallout. Extracted Version,

    DTIC Science & Technology

    Fallout, *Radiation injuries, Exposure(General), Radioactive materials, Nuclear explosion testing, Bikini Atoll, Indigenous population, Marshall ... Islands , Military forces(United States), Villages, Decontamination, Lesions, Therapy, Hematology, Dosimetry

  4. Career Development: Revolution, Reform, and Renaissance.

    ERIC Educational Resources Information Center

    Patterson, John

    1985-01-01

    Discusses elements to be considered by career counselors, including robotics, fiber optics, biotechnology, space industry, transition from industry to information, expected labor shortage in the 1990s, population trends, and entrepreneurial explosion. Also describes four basic skills of the information society. (CT)

  5. Challenges of the Scientific Age

    ERIC Educational Resources Information Center

    Rabinowitch, Eugene

    1973-01-01

    The author, who was working on this article at the time of his death, expresses his views on the energy crisis and the problems of environmental pollution associated with it. In his estimation, both problems are products of the population explosion. (Editor/JR)

  6. Fragmentation of structural energetic materials: implications for performance

    NASA Astrophysics Data System (ADS)

    Aydelotte, B.; Braithwaite, C. H.; Thadhani, N. N.

    2014-05-01

    Fragmentation results for structural energetic materials based on intermetallic forming mixtures are reviewed and the implications of the fragment populations are discussed. Cold sprayed Ni+Al and explosively compacted mixtures of Ni+Al+W and Ni+Al+W+Zr powders were fabricated into ring shaped samples and explosively fragmented. Ring velocity was monitored and fragments were soft captured in order to study the fragmentation process. It was determined that the fragments produced by these structural energetic materials are much smaller than those typically produced by ductile metals such as steel or aluminum. This has implications for combustion processes that may occur subsequent to the fragmentation process.

  7. National Strategy for Combating Terrorism: Prospects and Implications

    DTIC Science & Technology

    2003-12-01

    America’s security, to bolster America’s economic prosperity, and to promote democracy and human rights...their canine explosives detection programs. Customs increased searches of passengers, baggage, and cargo leaving the US. Finally, the ATF was...The Bush strategy is built around three goals: political and economic freedom, peaceful relations with other states, and respect for human dignity

  8. Strategic Factors Influencing the British and American Empires

    DTIC Science & Technology

    2003-04-07

    benefits of the Industrial Revolution ; and Britain was one of the major leaders in that revolution. Britain reaped the rewards of its pioneering role in the... Industrial Revolution was accompanied by a population explosion within the British Isles. Had Britain remained a largely agrarian country, it is believed...that there would have been widespread famine.37 Instead, the Industrial Revolution provided the factories that absorbed much of the excess population

  9. Extinction and recolonization of local populations on a growing shield volcano.

    PubMed Central

    Carson, H L; Lockwood, J P; Craddock, E M

    1990-01-01

    Volcanic action has resulted in the burial of the surfaces of Mauna Loa and Kilauea, Hawaii, by new lava flows at rates as high as 90% per 1000 years. Local populations of organisms on such volcanoes are continually being exterminated; survival of the species requires colonization of younger flows. Certain populations of the endemic Hawaiian species Drosophila silvestris exemplify such events in microcosm. Local populations at the base of an altitudinal cline were destroyed by two explosive eruptions within the last 2100 years. Natural recolonization restored the cline except for one young population that is genetically discordant with altitude. Images PMID:11607102

  10. Explosive X-point collapse in relativistic magnetically dominated plasma

    NASA Astrophysics Data System (ADS)

    Lyutikov, Maxim; Sironi, Lorenzo; Komissarov, Serguei S.; Porth, Oliver

    2017-12-01

    The extreme properties of the gamma-ray flares in the Crab nebula present a clear challenge to our ideas on the nature of particle acceleration in relativistic astrophysical plasma. It seems highly unlikely that standard mechanisms of stochastic type are at work here and hence the attention of theorists has switched to linear acceleration in magnetic reconnection events. In this series of papers, we attempt to develop a theory of explosive magnetic reconnection in highly magnetized relativistic plasma which can explain the extreme parameters of the Crab flares. In the first paper, we focus on the properties of the X-point collapse. Using analytical and numerical methods (fluid and particle-in-cell simulations) we extend Syrovatsky's classical model of such collapse to the relativistic regime. We find that the collapse can lead to the reconnection rate approaching the speed of light on macroscopic scales. During the collapse, the plasma particles are accelerated by charge-starved electric fields, which can reach (and even exceed) values of the local magnetic field. The explosive stage of reconnection produces non-thermal power-law tails with slopes that depend on the average magnetization . For sufficiently high magnetizations and vanishing guide field, the non-thermal particle spectrum consists of two components: a low-energy population with soft spectrum that dominates the number census; and a high-energy population with hard spectrum that possesses all the properties needed to explain the Crab flares.

  11. THE HOST GALAXY OF THE SUPER-LUMINOUS SN 2010gx AND LIMITS ON EXPLOSIVE {sup 56}Ni PRODUCTION

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chen, Ting-Wan; Smartt, Stephen J.; Kotak, Rubina

    2013-02-01

    Super-luminous supernovae have a tendency to occur in faint host galaxies which are likely to have low mass and low metallicity. While these extremely luminous explosions have been observed from z = 0.1 to 1.55, the closest explosions allow more detailed investigations of their host galaxies. We present a detailed analysis of the host galaxy of SN 2010gx (z = 0.23), one of the best studied super-luminous type Ic supernovae. The host is a dwarf galaxy (M{sub g} = -17.42 {+-} 0.17) with a high specific star formation rate. It has a remarkably low metallicity of 12 + log (O/H)more » = 7.5 {+-} 0.1 dex as determined from the detection of the [O III] {lambda}4363 line. This is the first reliable metallicity determination of a super-luminous stripped-envelope supernova host. We collected deep multi-epoch imaging with Gemini + GMOS between 240 and 560 days after explosion to search for any sign of radioactive {sup 56}Ni, which might provide further insights on the explosion mechanism and the progenitor's nature. We reach griz magnitudes of m{sub AB} {approx} 26, but do not detect SN 2010gx at these epochs. The limit implies that any {sup 56}Ni production was similar to or below that of SN 1998bw (a luminous type Ic SN that produced around 0.4 M{sub Sun} of {sup 56}Ni). The low volumetric rates of these supernovae ({approx}10{sup -4} of the core-collapse population) could be qualitatively matched if the explosion mechanism requires a combination of low-metallicity (below 0.2 Z{sub Sun }), high progenitor mass (>60 M{sub Sun }) and high rotation rate (fastest 10% of rotators).« less

  12. The Energy Crisis: A New Chemistry Course for Nonscience Majors

    ERIC Educational Resources Information Center

    Piraino, Marie J.

    1974-01-01

    Describes a course structured around nuclear energy, fossil fuel energy, food energy, and the population explosion. The course uses classroom discussion and laboratory sessions to stress basic chemical principles and relevance to the student. A topical outline is included. (GS)

  13. Explosive-residue compounds resulting from snow avalanche control in the Wasatch Mountains of Utah

    USGS Publications Warehouse

    Naftz, David L.; Kanagy, Leslie K.; Susong, David D.; Wydoski, Duane S.; Kanagy, Christopher J.

    2003-01-01

    A snow avalanche is a powerful force of nature that can play a significant role in developing mountain landscapes (Perla and Martinelli, 1975). More importantly, loss of life can occur when people are caught in the path of snow avalanches (Grossman, 1999). Increasing winter recreation, including skiing, snowboarding, snowmobiling, snowshoeing, and climbing in mountainous areas, has increased the likelihood of people encountering snow avalanches (fig. 1). Explosives are used by most ski areas and State highway departments throughout the Western United States to control the release of snow avalanches, thus minimizing the loss of human life during winter recreation and highway travel (fig. 2).Common explosives used for snow avalanche control include trinitrotoluene (TNT), pentaerythritoltetranitrate (PETN), cyclotrimethylenetrinitramine (RDX), tetrytol, ammonium nitrate, and nitroglycerin (Perla and Martinelli, 1975). During and after snowfall or wind loading of potential avalanche slopes, ski patrollers and Utah Department of Transportation personnel deliver explosive charges onto predetermined targets to artificially release snow avalanches, thereby rendering the slope safer for winter activities. Explosives can be thrown by hand onto target zones or shot from cannons for more remote delivery of explosive charges. Hand-delivered charges typically contain about 2 pounds of TNT or its equivalent (Perla and Martinelli, 1975).Depending on the size of the ski area, acreage of potential avalanche terrain, and weather conditions, the annual quantity of explosives used during a season of snow avalanche control can be substantial. For example, the three ski areas of Alta, Snowbird, and Brighton, plus the Utah Department of Transportation, may use as many as 11,200 hand charges per year (Wasatch Powderbird Guides, unpub. data, 1999) for snow avalanche control in Big and Little Cottonwood Canyons (fig. 3). If each charge is assumed to weigh 2 pounds, this equates to about 22,400 pounds of explosive hand charges per year. In addition, 2,240 to 3,160 Avalauncher rounds and 626 to 958 military artillery rounds (explosive mass not specified) are used each year by the three ski areas and the Utah Department of Transportation for snow avalanche control in Big and Little Cottonwood Canyons (Wasatch Powderbird Guides, unpub. data, 1999). The other ski area in Big Cottonwood Canyon, Brighton, uses about 2,000 pounds of explosives per year for snow avalanche control (Michele Weidner, Cirrus Ecological Solutions consultant, written commun., 2001).

  14. The Merapi 2010 eruption: An interdisciplinary impact assessment methodology for studying pyroclastic density current dynamics

    NASA Astrophysics Data System (ADS)

    Jenkins, S.; Komorowski, J.-C.; Baxter, P. J.; Spence, R.; Picquout, A.; Lavigne, F.; Surono

    2013-07-01

    The large explosive eruption of Merapi volcano, Indonesia, in 2010 presented a key, and rare, opportunity to study the impacts of a major explosive eruption in a densely populated area. Pyroclastic density currents (PDCs) produced throughout the 2010 eruption were unusually destructive, causing near complete devastation across a 22 km2 swath of the densely populated southern flanks and casualties to the end of their runout at 15.5 km from the volcano. The majority (> 120) of the more than 200 fatalities occurred more than 12 km from the volcano, where many people were caught in PDCs as they were evacuating. The 2010 eruption (VEI 4) exhibited a range of PDC behaviour in a complex multi-stage event that marked a change in eruption behaviour at Merapi, being the first eruption of this magnitude and style since 1872. This shift in style may mark a change in regime, and so understanding the potential impact of such large explosive eruptions is essential for future risk-assessment at Merapi. We describe a new impact assessment methodology that allowed us to collect important empirical geological, damage and casualty information and reconstruct impact dynamics associated with the PDCs. In contrast to previous PDC impact studies, we combined remote, field, laboratory and GIS assessments and were able to enter the affected areas safely and before their disturbance by rains or human activity. By integrating the results of our geological, damage and medical studies, we could reconstruct the spatial and temporal dynamics of the PDCs and their main hazard characteristics. Our interdisciplinary methods and preliminary findings are discussed here. In the areas damaged by PDCs, we used empirical damage data and calculations of material and structural resistance to lateral force to estimate approximate dynamic pressures. Dynamic pressures associated with the 5 November paroxysm exceeded 15 kPa more than 6 km from source and rapidly attenuated over a distance of less than 1 km at the end of the PDC runouts. Analysis of thermal indicators, such as deformed plastic, and correlation with information on burns injuries and fires provided estimates of ambient temperatures associated with the PDCs. Even at the relatively low temperatures estimated for the PDCs (200-300 °C) they were lethal to people inside as well as outside buildings, in part because of the building design that enabled the PDCs to rapidly infiltrate inside. Such detailed quantitative data can be used to support numerical PDC and impact modelling and risk assessment at dome-forming volcanoes, providing an improved understanding of the complexity of PDCs and their associated impacts on exposed populations.

  15. Pancreatic Cancer

    PubMed Central

    Maitra, Anirban; Hruban, Ralph H.

    2009-01-01

    The past two decades have witnessed an explosion in our understanding of pancreatic cancer, and it is now clear that pancreatic cancer is a disease of inherited (germ-line) and somatic gene mutations. The genes mutated in pancreatic cancer include KRAS2, p16/CDKN2A, TP53, and SMAD4/DPC4, and these are accompanied by a substantial compendium of genomic and transcriptomic alterations that facilitate cell cycle deregulation, cell survival, invasion, and metastases. Pancreatic cancers do not arise de novo, and three distinct precursor lesions have been identified. Experimental models of pancreatic cancer have been developed in genetically engineered mice, which recapitulate the multistep progression of the cognate human disease. Although the putative cell of origin for pancreatic cancer remains elusive, minor populations of cells with stem-like properties have been identified that appear responsible for tumor initiation, metastases, and resistance of pancreatic cancer to conventional therapies. PMID:18039136

  16. Take immediate action to protect communities and workers.

    PubMed

    Wilding, Roberta Chase; Lewis, Sharon E

    2007-01-01

    In many areas throughout America, thousands of industrial and military facilities and agricultural operations put large numbers of people at risk of serious injury or death due to accidental chemical releases, explosions, fires, and grossly inadequate occupational exposure standards. While some companies are moving toward "greener" production, many others do the minimum required by government agencies. As evidenced by the thousands of permit violations and accidental releases of hazardous chemicals, this means that facilities across the country consistently fail to meet regulations, incorporating the cost of fines and penalties into the cost of doing business and passing that cost on to consumers. Workers at such facilities and residents of the surrounding communities cannot wait for the eventual implementation and enforcement of federal environmental laws or adequate testing of the effect chemicals may have on the human population. Immediate action is needed to protect communities and workers at risk from chemical exposures that can compromise their health.

  17. [Danger from exploding fireworks and blank firearms].

    PubMed

    Just, T; Pau, H W; Kaduk, W; Hingst, V

    2000-12-01

    Explosive amusement and deterrent articles such as New Year's Eve cannons and rockets, toy pistols, and blank guns are not at all harmless items. Their potential dangerousness is often extremely underestimated. Two damaging mechanisms are important: during explosions, high pressures and temperatures develop and a considerable sound pressure level can be measured. If the explosion happens near the human body (intentionally or inadvertently), not only superficial lesions can occur, but also (mainly due to contact shots) serious, deep-seated tissue damage, especially in the head and neck region with its endangered sense organs such as eye and ear, the vessels and nerves supplying the brain, the speech- and voice-forming apparatus, and in particular the face, can be the consequence. Their mutilation can lead to serious and extensive interpersonalchanges. Accidents are published in the relevant otological and forensic medical papers, but nevertheless it seems important to us to point out the dangerousness of these readily available items.

  18. Textural evolution of magma during the 9.4-ka trachytic explosive eruption at Kilian Volcano, Chaîne des Puys, France

    NASA Astrophysics Data System (ADS)

    Colombier, M.; Gurioli, L.; Druitt, T. H.; Shea, T.; Boivin, P.; Miallier, D.; Cluzel, N.

    2017-02-01

    Textural parameters such as density, porosity, pore connectivity, permeability, and vesicle size distributions of vesiculated and dense pyroclasts from the 9.4-ka eruption of Kilian Volcano, were quantified to constrain conduit and eruptive processes. The eruption generated a sequence of five vertical explosions of decreasing intensity, producing pyroclastic density currents and tephra fallout. The initial and final phases of the eruption correspond to the fragmentation of a degassed plug, as suggested by the increase of dense juvenile clasts (bimodal density distributions) as well as non-juvenile clasts, resulting from the reaming of a crater. In contrast, the intermediate eruptive phases were the results of more open-conduit conditions (unimodal density distributions, decreases in dense juvenile pyroclasts, and non-juvenile clasts). Vesicles within the pyroclasts are almost fully connected; however, there are a wide range of permeabilities, especially for the dense juvenile clasts. Textural analysis of the juvenile clasts reveals two vesiculation events: (1) an early nucleation event at low decompression rates during slow magma ascent producing a population of large bubbles (>1 mm) and (2) a syn-explosive nucleation event, followed by growth and coalescence of small bubbles controlled by high decompression rates immediately prior to or during explosive fragmentation. The similarities in pyroclast textures between the Kilian explosions and those at Soufrière Hills Volcano on Montserrat, in 1997, imply that eruptive processes in the two systems were rather similar and probably common to vulcanian eruptions in general.

  19. Teacher in Space Christa McAuliffe talks to the media

    NASA Image and Video Library

    1984-07-12

    S85-37164 (8-12 July 1985) --- Sharon C. (Christa) McAuliffe of Concord High, Concord, New Hampshire, talks to the media at Johnson Space Center. Christa McAuliffe was eventually chosen as the first Teacher in Space and was a member of the seven-member Challenger shuttle crew which died tragically in the explosion of the spacecraft during the launch of STS-51L from the Kennedy Space Center about 11:40 a.m., EST, on Jan. 28, 1986. The explosion occurred 73 seconds into the flight as a result of a leak in one of two Solid Rocket Boosters that ignited the main liquid fuel tank. The crew members of the Challenger represented a cross-section of the American population in terms of race, gender, geography, background, and religion. The explosion became one of the most significant events of the 1980s, as billions around the world saw the accident on television and empathized with any one of the several crew members killed. Photo credit: NASA

  20. Ion-coincidence momentum imaging of three-body Coulomb explosion of formaldehyde in ultrashort intense laser fields

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fushitani, M.; Matsuda, A.; Hishikawa, A., E-mail: hishi@chem.nagoya-u.ac.jp

    Three-body Coulomb explosion of formaldehyde (H{sub 2}CO) in intense 7- and 35-fs laser fields (1.3 × 10{sup 15} W/cm{sup 2}) has been investigated by using ion-coincidence momentum imaging technique. Two types of explosion pathways from the triply charged state, H{sub 2}CO{sup 3+} → (i) H{sup +} + H{sup +} + CO{sup +} and (ii) H{sup +} + CH{sup +} + O{sup +}, have been identified. It is shown from the momentum correlation of the fragment ions of pathway (i), that the geometrical structure of the molecule is essentially frozen along the H-C-H bending coordinate for the 7-fs case. On the othermore » hand, for a longer pulse duration (35 fs), structural deformation along the C-H stretching and H-C-H bending coordinates is identified, which is ascribed to the nuclear dynamics in the dication states populated within the laser pulse duration.« less

  1. Detectability of the first cosmic explosions

    NASA Astrophysics Data System (ADS)

    de Souza, R. S.; Ishida, E. E. O.; Johnson, J. L.; Whalen, D. J.; Mesinger, A.

    2013-12-01

    We present a fully self-consistent simulation of a synthetic survey of the furthermost cosmic explosions. The appearance of the first generation of stars (Population III) in the Universe represents a critical point during cosmic evolution, signalling the end of the dark ages, a period of absence of light sources. Despite their importance, there is no confirmed detection of Population III stars so far. A fraction of these primordial stars are expected to die as pair-instability supernovae (PISNe), and should be bright enough to be observed up to a few hundred million years after the big bang. While the quest for Population III stars continues, detailed theoretical models and computer simulations serve as a testbed for their observability. With the upcoming near-infrared missions, estimates of the feasibility of detecting PISNe are not only timely but imperative. To address this problem, we combine state-of-the-art cosmological and radiative simulations into a complete and self-consistent framework, which includes detailed features of the observational process. We show that a dedicated observational strategy using ≲ 8 per cent of the total allocation time of the James Webb Space Telescope mission can provide us with up to ˜9-15 detectable PISNe per year.

  2. Technology and Education: Friends or Foes?

    ERIC Educational Resources Information Center

    Pelton, Joseph N.

    The population explosion and developments in information technology have created a powerful need for technological advancement on a global scale. Such advancement must come through education, and such education, given the size and breadth of the need, is best realized through multimedia instruction and distance education. Communications…

  3. The Environment of Crises in the Nigerian Education System.

    ERIC Educational Resources Information Center

    Nwagwu, Cordelia C.

    1997-01-01

    During 1960-95, unplanned and uncontrolled educational expansion in Nigeria, coupled with a population explosion, military coups, and a depressed economy, created an environment of crisis in the educational system. Problems included poor funding; inadequate facilities; corruption in admissions, certification, and examination practices; emergence…

  4. The Ants Go Marching Millions by Millions: Invasive Ant Research

    USDA-ARS?s Scientific Manuscript database

    Invasive ants are a worldwide problem that is expanding both geographically and in intensity. Population explosions of invasive ants can overrun landscapes and inundate structures. Pest management professionals are often the first responders to complaints about invading ants. This session will fo...

  5. The ants go marching millions by millions: invasive ant research

    USDA-ARS?s Scientific Manuscript database

    Invasive ants are a worldwide problem that is expanding both geographically and in intensity. Population explosions of invasive ants can overrun landscapes and inundate structures. Pest management professionals are often the first responders to complaints about invading ants. This session will fo...

  6. Are There Spatial or Temporal Patterns to Holocene Explosive Eruptions in the Aleutian Archipelago? A Work in Progress

    NASA Astrophysics Data System (ADS)

    Martin, C.; Nicolaysen, K. P.; McConville, K.; Hatfield, V.; West, D.

    2013-12-01

    By examining the existing geological and archeological record of radiocarbon dated Aleutian tephras of the last 12,000 years, this study sought to determine whether there were spatial or temporal patterns of explosive eruptive activity. The Holocene tephra record has important implications because two episodes of migration and colonization by humans of distinct cultures established the Unangan/Aleut peoples of the Aleutian Islands concurrently with the volcanic activity. From Aniakchak Volcano on the Alaska Peninsula to the Andreanof Islands (158 to 178° W longitude), 55 distinct tephras represent significant explosive eruptions of the last 12,000 years. Initial results suggest that the Andreanof and Fox Island regions of the archipelago have had frequent explosive eruptions whereas the Islands of Four Mountains, Rat, and Near Island regions have apparently had little or no eruptive activity. However, one clear result of the investigation is that sampling bias strongly influences the apparent spatial patterns. For example field reconnaissance in the Islands of Four Mountains documents two Holocene calderas and a minimum of 20 undated tephras in addition to the large ignimbrites. Only the lack of significant explosive activity in the Near Islands seems a valid spatial result as archeological excavations and geologic reports failed to document Holocene tephras there. An intriguing preliminary temporal pattern is the apparent absence of large explosive eruptions across the archipelago from ca. 4,800 to 6,000 yBP. To test the validity of apparent patterns, a statistical treatment of the compiled data grappled with the sampling bias by considering three confounding variables: larger island size allows more opportunity for geologic preservation of tephras; larger magnitude eruption promotes tephra preservation by creating thicker and more widespread deposits; the comprehensiveness of the tephra sampling of each volcano and island varies widely because of logistical and financial limitations. This initial statistical investigation proposes variables to mitigate the effects of sampling bias and makes recommendations for sampling strategies to enable statistically valid examination of research questions. Further, though caldera-forming eruptions occurred throughout the Holocene - and several remain undated - four of six dated eruptions occurred throughout the archipelago between 8,000-9,100 yBP, a period coinciding with some of the earliest human occupation (Early Anangula Phase) of the eastern Aleutians.

  7. Humans to Mars: The Greatest Adventure in Human History

    NASA Technical Reports Server (NTRS)

    Levine, Joel S.; Schild,Rudy

    2011-01-01

    The reasons for a human mission to Mars are many and include (1) World technological leadership, (2) Enhanced national security, (3) Enhanced economic vitality, (4) The human urge to explore new and distant frontiers, (5) Scientific discovery (how did Mars evolve from an early Earth-like, hospitable planet to its present inhospitable state? Is there life on Mars?) (6) Inspiring the American public and the next generation of scientists and engineers (following the launch of Sputnik I by the USSR on October 4, 1957, the U. S. and the rest of the world witnessed a significant increase in the number of students going into science and engineering), (7) Develop new technologies for potential non-space spin-off applications, and, (8) Enhanced national prestige, etc. Other reasons for colonizing the Red Planet are more catastrophic in nature, including Mars as a safe haven for the survival of the human species in the event of an impact with a large asteroid (remember the demise of the dinosaurs 65-million years as a result of an asteroid impact!). Some have also suggested that the colonization of Mars may be a solution to the global exponential population explosion on our planet! A human mission to and the colonization of the Red Planet requires multi-disciplined expertise in many areas including engineering, technology, science, human health and medicine and the human psychological and behavior. To capture the relevant areas of needed expertise, we have invited a group of more than 70 U. S. and foreign experts in these areas, including astronauts, scientists, engineers, technologists, medical doctors, psychologists and economists to share their views and thoughts on a human mission to Mars.

  8. Biological Databases for Human Research

    PubMed Central

    Zou, Dong; Ma, Lina; Yu, Jun; Zhang, Zhang

    2015-01-01

    The completion of the Human Genome Project lays a foundation for systematically studying the human genome from evolutionary history to precision medicine against diseases. With the explosive growth of biological data, there is an increasing number of biological databases that have been developed in aid of human-related research. Here we present a collection of human-related biological databases and provide a mini-review by classifying them into different categories according to their data types. As human-related databases continue to grow not only in count but also in volume, challenges are ahead in big data storage, processing, exchange and curation. PMID:25712261

  9. Method for combined biometric and chemical analysis of human fingerprints.

    PubMed

    Staymates, Jessica L; Orandi, Shahram; Staymates, Matthew E; Gillen, Greg

    This paper describes a method for combining direct chemical analysis of latent fingerprints with subsequent biometric analysis within a single sample. The method described here uses ion mobility spectrometry (IMS) as a chemical detection method for explosives and narcotics trace contamination. A collection swab coated with a high-temperature adhesive has been developed to lift latent fingerprints from various surfaces. The swab is then directly inserted into an IMS instrument for a quick chemical analysis. After the IMS analysis, the lifted print remains intact for subsequent biometric scanning and analysis using matching algorithms. Several samples of explosive-laden fingerprints were successfully lifted and the explosives detected with IMS. Following explosive detection, the lifted fingerprints remained of sufficient quality for positive match scores using a prepared gallery consisting of 60 fingerprints. Based on our results ( n  = 1200), there was no significant decrease in the quality of the lifted print post IMS analysis. In fact, for a small subset of lifted prints, the quality was improved after IMS analysis. The described method can be readily applied to domestic criminal investigations, transportation security, terrorist and bombing threats, and military in-theatre settings.

  10. Planar blast scaling with condensed-phase explosives in a shock tube

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jackson, Scott L

    2011-01-25

    Blast waves are strong shock waves that result from large power density deposition into a fluid. The rapid energy release of high-explosive (HE) detonation provides sufficiently high power density for blast wave generation. Often it is desirable to quantify the energy released by such an event and to determine that energy relative to other reference explosives to derive an explosive-equivalence value. In this study, we use condensed-phase explosives to drive a blast wave in a shock tube. The explosive material and quantity were varied to produce blast waves of differing strengths. Pressure transducers at varying lengths measured the post-shock pressure,more » shock-wave arrival time and sidewall impulse associated with each test. Blast-scaling concepts in a one-dimensional geometry were then used to both determine the energy release associated with each test and to verify the scaling of the shock position versus time, overpressure versus distance, and impulse. Most blast scaling measurements to-date have been performed in a three-dimensional geometry such as a blast arena. Testing in a three-dimensional geometry can be challenging, however, as spherical shock-wave symmetry is required for good measurements. Additionally, the spherical wave strength decays rapidly with distance and it can be necessary to utilize larger (several kg) quantities of explosive to prevent significant decay from occurring before an idealized blast wave has formed. Such a mode of testing can be expensive, require large quantities of explosive, and be limited by both atmospheric conditions (such as rain) and by noise complaints from the population density near the test arena. Testing is possible in more compact geometries, however. Non-planar blast waves can be formed into a quasi-planar shape by confining the shock diffraction with the walls of a shock tube. Regardless of the initial form, the wave shape will begin to approximate a planar front after successive wave reflections from the tube walls. Such a technique has previously been used to obtain blast scaling measurements in the planar geometry with gaseous explosives and the condensed-phase explosive nitroguanidine. Recently, there has been much interest in the blast characterization of various non-ideal high explosive (NIHE) materials. With non-ideals, the detonation reaction zone is significantly larger (up to several cm for ANFO) than more ideal explosives. Wave curvature, induced by charge-geometry, can significantly affect the energy release associated with NIHEs. To measure maximum NIHE energy release accurately, it is desirable to minimize any such curvature and, if possible, to overdrive the detonation shock to ensure completion of chemical reactions ahead of the sonic locus associated with the reaction zone. This is achieved in the current study through use of a powerful booster HE and a charge geometry consisting of short cylindrical lengths of NIHE initiated along the charge centerline.« less

  11. Hazard maps of Colima volcano, Mexico

    NASA Astrophysics Data System (ADS)

    Suarez-Plascencia, C.; Nunez-Cornu, F. J.; Escudero Ayala, C. R.

    2011-12-01

    Colima volcano, also known as Volcan de Fuego (19° 30.696 N, 103° 37.026 W), is located on the border between the states of Jalisco and Colima and is the most active volcano in Mexico. Began its current eruptive process in February 1991, in February 10, 1999 the biggest explosion since 1913 occurred at the summit dome. The activity during the 2001-2005 period was the most intense, but did not exceed VEI 3. The activity resulted in the formation of domes and their destruction after explosive events. The explosions originated eruptive columns, reaching attitudes between 4,500 and 9,000 m.a.s.l., further pyroclastic flows reaching distances up to 3.5 km from the crater. During the explosive events ash emissions were generated in all directions reaching distances up to 100 km, slightly affected nearby villages as Tuxpan, Tonila, Zapotlán, Cuauhtemoc, Comala, Zapotitlan de Vadillo and Toliman. During the 2005 this volcano has had an intense effusive-explosive activity, similar to the one that took place during the period of 1890 through 1900. Intense pre-plinian eruption in January 20, 1913, generated little economic losses in the lower parts of the volcano due to low population density and low socio-economic activities at the time. Shows the updating of the volcanic hazard maps published in 2001, where we identify whit SPOT satellite imagery and Google Earth, change in the land use on the slope of volcano, the expansion of the agricultural frontier on the east and southeast sides of the Colima volcano, the population inhabiting the area is approximately 517,000 people, and growing at an annual rate of 4.77%, also the region that has shown an increased in the vulnerability for the development of economic activities, supported by the construction of highways, natural gas pipelines and electrical infrastructure that connect to the Port of Manzanillo to Guadalajara city. The update the hazard maps are: a) Exclusion areas and moderate hazard for explosive events (rockfall) and pyroclastic flows, b) Hazard map of lahars and debris flow, and c) Hazard map of ash-fall. The cartographic and database information obtained will be the basis for updating the Operational Plan of the Colima Volcano by the State Civil & Fire Protection Unit of Jalisco, Mexico, and the urban development plans of surrounding municipalities, in order to reduce their vulnerability to the hazards of the volcanic activity.

  12. Psychology, the Population Explosion, and the Question of Freedom and Dignity.

    ERIC Educational Resources Information Center

    Platzek, Donna Brown

    This paper examines the question of why women want children from several disciplinary viewpoints including psychoanalysis; role learning; and economic, political, and religious aspects. Basically, however, childbearing motivations can be divided into four categories: altruistic, fatalistic, narcissistic, and instrumental. Children can fulfill a…

  13. Travel and Learn -- About Yourself

    ERIC Educational Resources Information Center

    Nadler, Leonard

    1971-01-01

    While serving as consultant to a New Delhi workshop on literacy education and family planning, Nadler considers some of the same problems in the United States -- population explosions, the effects of religious practices, training of teachers, polarization of adult educators with their own group, and the difficulty of bringing professional…

  14. A Late Holocene explosive mafic eruption of Villarrica volcano, Southern Andes: The Chaimilla deposit

    NASA Astrophysics Data System (ADS)

    Costantini, L.; Pioli, L.; Bonadonna, C.; Clavero, J.; Longchamp, C.

    2011-03-01

    Villarrica (Chile) is one of the most active volcanoes in South America having erupted about 60 times in the last 460 years. Although its historical eruptive activity has been mainly effusive and weakly explosive, it had strong explosive behaviour in postglacial times. Chaimilla (< 3.1 ka) is one of the best exposed and widely dispersed pyroclastic deposits, related to both fall and flow activity. The deposit is dispersed over an area of 250 km 2 and consists of 8 units (A-H) which were grouped into four sequences. Stratigraphic data suggest that the eruption had a relatively short duration and evolved from i) an Opening phase, dispersing ash, lapilli clasts, accretionary lapilli, blocks and bombs, to ii) a Pulsatory phase, originating a series of magmatic explosions, to iii) a Collapsing phase, characterised by unstable plumes which emplaced a series of pyroclastic density currents intercalated with thin fallout layers and finally to iv) a Climactic phase forming a more sustained plume which eventually collapsed generating the final pyroclastic density currents. The deposit (fall and flow) has a minimum cumulative volume of 0.6 km 3, with the main sustained phase being associated with a VEI 4 and the flow units having a minimum estimated total volume of 0.04 km 3. The erupted material has a homogenous chemical composition but displays a remarkable variability in both textural and physical properties. The density distribution of juvenile products shows a clear bimodality characterised by two main populations: P1 and P2. Population P1 consists of highly vesicular clasts (modal density around 1000 kg m - 3 ) with mostly sub-spherical bubbles and moderately crystallised groundmass with large-sized microlites. Clasts from population P2 are poorly vesicular (modal density around 1600 kg m - 3 ) with irregular to collapsed bubbles and numerous smaller microlites. The variability of both vesicularity and microlite characteristics suggests the involvement of two magma batches with distinct pre-eruptive degassing and rising histories. Our eruption conceptual model implies the arrival of new magma (represented in the deposit by P1 clasts) into a small, outgassed magma body which was accumulated at shallow level (mainly represented by P2 clasts). A new Chaimilla-type eruption could significantly affect the communities that have recently developed around Villarrica volcano and subsist mainly on tourism and forestry. As a result, a better understanding of the dynamics and evolution of the Chaimilla eruption is necessary for the identification of potential hazard scenarios at Villarrica volcano and, ultimately, for the risk mitigation of this populated area of Southern Chile.

  15. Supervised Machine Learning for Population Genetics: A New Paradigm

    PubMed Central

    Schrider, Daniel R.; Kern, Andrew D.

    2018-01-01

    As population genomic datasets grow in size, researchers are faced with the daunting task of making sense of a flood of information. To keep pace with this explosion of data, computational methodologies for population genetic inference are rapidly being developed to best utilize genomic sequence data. In this review we discuss a new paradigm that has emerged in computational population genomics: that of supervised machine learning (ML). We review the fundamentals of ML, discuss recent applications of supervised ML to population genetics that outperform competing methods, and describe promising future directions in this area. Ultimately, we argue that supervised ML is an important and underutilized tool that has considerable potential for the world of evolutionary genomics. PMID:29331490

  16. Nepal: a potentially explosive situation.

    PubMed

    Gurung, A

    1993-01-01

    90% of Nepal's population is engaged in agriculture; the rural children lack all modern amenities and facilities, and boys are given preference over girls, who do not attend school. In urban populations, girls and boys are treated equally; however, 150,000 children, aged 7 to 16 years, work in carpet factories in unhygienic conditions. 52.71% are illiterate; 47.29% are dropouts. Others work as domestic servants, dishwashers in restaurants, or ragpickers. Many fortunate children do attend schools, which are numerous and filled to capacity. But thousands of Nepalese girls are sold to brothels in Bombay, Calcutta, and other parts of India; upon their return home, they bring human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) with them, as do thousands of male adult migrant workers. A government agency, AIDS Prevention and Control Programme, and about 50 nongovernmental organizations (NGOs) are collaborating to help persons who are infected with HIV or suffering from AIDS. Caritas works with two of the NGOs on a mass education program, prevention, and rehabilitation of HIV-positive women. Although government statistics indicate there are 133 identified cases of HIV in Nepal, the World Health Organization estimates the number of people there who are infected with HIV to be 10,000.

  17. The reluctant innovator: orangutans and the phylogeny of creativity

    PubMed Central

    van Schaik, C. P.; Burkart, J.; Damerius, L.; Forss, S. I. F.; Koops, K.; van Noordwijk, M. A.; Schuppli, C.

    2016-01-01

    Young orangutans are highly neophobic, avoid independent exploration and show a preference for social learning. Accordingly, they acquire virtually all their learned skills through exploration that is socially induced. Adult exploration rates are also low. Comparisons strongly suggest that major innovations, i.e. behaviours that have originally been brought into the population through individual invention, are made where ecological opportunities to do so are propitious. Most populations nonetheless have large innovation repertoires, because innovations, once made, are retained well through social transmission. Wild orangutans are therefore not innovative. In striking contrast, zoo-living orangutans actively seek novelty and are highly exploratory and innovative, probably because of positive reinforcement, active encouragement by human role models, increased sociality and an expectation of safety. The explanation for this contrast most relevant to hominin evolution is that captive apes generally have a highly reduced cognitive load, in particular owing to the absence of predation risk, which strongly reduces the costs of exploration. If the orangutan results generalize to other great apes, this suggests that our ancestors could have become more curious once they had achieved near-immunity to predation on the eve of the explosive increase in creativity characterizing the Upper Palaeolithic Revolution. PMID:26926274

  18. Identifying the Volcanic Eruption Depicted in a Neolithic Painting at Çatalhöyük, Central Anatolia, Turkey

    PubMed Central

    Schmitt, Axel K.; Danišík, Martin; Aydar, Erkan; Şen, Erdal; Ulusoy, İnan; Lovera, Oscar M.

    2014-01-01

    A mural excavated at the Neolithic Çatalhöyük site (Central Anatolia, Turkey) has been interpreted as the oldest known map. Dating to ∼6600 BCE, it putatively depicts an explosive summit eruption of the Hasan Dağı twin-peaks volcano located ∼130 km northeast of Çatalhöyük, and a birds-eye view of a town plan in the foreground. This interpretation, however, has remained controversial not least because independent evidence for a contemporaneous explosive volcanic eruption of Hasan Dağı has been lacking. Here, we document the presence of andesitic pumice veneer on the summit of Hasan Dağı, which we dated using (U-Th)/He zircon geochronology. The (U-Th)/He zircon eruption age of 8.97±0.64 ka (or 6960±640 BCE; uncertainties 2σ) overlaps closely with 14C ages for cultural strata at Çatalhöyük, including level VII containing the “map” mural. A second pumice sample from a surficial deposit near the base of Hasan Dağı records an older explosive eruption at 28.9±1.5 ka. U-Th zircon crystallization ages in both samples range from near-eruption to secular equilibrium (>380 ka). Collectively, our results reveal protracted intrusive activity at Hasan Dağı punctuated by explosive venting, and provide the first radiometric ages for a Holocene explosive eruption which was most likely witnessed by humans in the area. Geologic and geochronologic lines of evidence thus support previous interpretations that residents of Çatalhöyük artistically represented an explosive eruption of Hasan Dağı volcano. The magmatic longevity recorded by quasi-continuous zircon crystallization coupled with new evidence for late-Pleistocene and Holocene explosive eruptions implicates Hasan Dağı as a potential volcanic hazard. PMID:24416270

  19. Incorporating Love- and Rayleigh-wave magnitudes, unequal earthquake and explosion variance assumptions and interstation complexity for improved event screening

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Anderson, Dale N; Bonner, Jessie L; Stroujkova, Anastasia

    Our objective is to improve seismic event screening using the properties of surface waves, We are accomplishing this through (1) the development of a Love-wave magnitude formula that is complementary to the Russell (2006) formula for Rayleigh waves and (2) quantifying differences in complexities and magnitude variances for earthquake and explosion-generated surface waves. We have applied the M{sub s} (VMAX) analysis (Bonner et al., 2006) using both Love and Rayleigh waves to events in the Middle East and Korean Peninsula, For the Middle East dataset consisting of approximately 100 events, the Love M{sub s} (VMAX) is greater than the Rayleighmore » M{sub s} (VMAX) estimated for individual stations for the majority of the events and azimuths, with the exception of the measurements for the smaller events from European stations to the northeast. It is unclear whether these smaller events suffer from magnitude bias for the Love waves or whether the paths, which include the Caspian and Mediterranean, have variable attenuation for Love and Rayleigh waves. For the Korean Peninsula, we have estimated Rayleigh- and Love-wave magnitudes for 31 earthquakes and two nuclear explosions, including the 25 May 2009 event. For 25 of the earthquakes, the network-averaged Love-wave magnitude is larger than the Rayleigh-wave estimate. For the 2009 nuclear explosion, the Love-wave M{sub s} (VMAX) was 3.1 while the Rayleigh-wave magnitude was 3.6. We are also utilizing the potential of observed variances in M{sub s} estimates that differ significantly in earthquake and explosion populations. We have considered two possible methods for incorporating unequal variances into the discrimination problem and compared the performance of various approaches on a population of 73 western United States earthquakes and 131 Nevada Test Site explosions. The approach proposes replacing the M{sub s} component by M{sub s} + a* {sigma}, where {sigma} denotes the interstation standard deviation obtained from the stations in the sample that produced the M{sub s} value. We replace the usual linear discriminant a* M{sub s}+b*{sub m{sub b}} with a* M{sub s}+b*{sub m{sub b}} + C*{sigma}. In the second approach, we estimate the optimum hybrid linear-quadratic discriminant function resulting from the unequal variance assumption. We observed slight improvement for the discriminant functions resulting from the theoretical interpretations of the unequal variance function. We have also studied the complexity of the ''magnitude spectra'' at each station. Our hypothesis is that explosion spectra should have fewer focal mechanism-produced complexities in the magnitude spectra than earthquakes. We have developed an intrastation ''complexity'' metric {Delta}M{sub s}, where {Delta}M{sub s} = M{sub s}(i)-M{sub s}(i+1) at periods, i, which are between 9 and 25 seconds. The complexity by itself has discriminating power but does not add substantially to the conditional hybrid discriminant that incorporates the differing spreads of the earthquake and explosion standard deviations.« less

  20. Interplay of explosive thermal reaction dynamics and structural confinement

    NASA Astrophysics Data System (ADS)

    Perry, W. Lee; Zucker, Jonathan; Dickson, Peter M.; Parker, Gary R.; Asay, Blaine W.

    2007-04-01

    Explosives play a significant role in human affairs; however, their behavior in circumstances other than intentional detonation is poorly understood. Accidents may have catastrophic consequences, especially if additional hazardous materials are involved. Abnormal ignition stimuli, such as impact, spark, friction, and heat may lead to a very violent outcome, potentially including detonation. An important factor influencing the behavior subsequent to abnormal ignition is the strength and inertia of the vessel confining the explosive, i.e., the near-field structural/mechanical environment, also known as confinement (inertial or mechanical). However, a comprehensive and quantified understanding of how confinement affects reaction violence does not yet exist. In the research discussed here, we have investigated a wide range of confinement conditions and related the explosive response to the fundamentals of the combustion process in the explosive. In our experiments, a charge of an octahydrotetranitrotetrazine-based plastic bonded explosive (PBX 9501) was loaded into a gun assembly having variable confinement conditions and subjected to a heating profile. The exploding charge breached the confinement and accelerated a projectile down the gun barrel. High bandwidth pressure and volume measurements were made and a first-law analysis was used to obtain enthalpy and power from the raw data. These results were then used to quantify reaction violence. Enthalpy change and power ranged from 0-1.8 kJ and 0-12 MW for 300 mg charges, respectively. Below a confinement strength of 20 MPa, violence was found to decline precipitously with decreasing confinement, while the violence for the heaviest confinement experiments was found to be relatively constant. Both pressure and pressurization rate were found to have critical values to induce and sustain violent reaction.

  1. Optimizing substance detection by integration of canine-human team with machine technology

    NASA Astrophysics Data System (ADS)

    Prestrude, Al M.; Ternes, J. W.

    1994-02-01

    There are several promising methods and technologies for substance detection. The oldest of these methods is the trained detector or `sniffer' dog. We summarize what is known about the capabilities of dogs in substance detection and recommend comparative testing of the canine- human team with current technology to identify the optimum combination of methods to maximize the detection of explosives and contraband.

  2. Psychological aspects of nuclear war

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Thompson, J.

    1985-01-01

    Exploring the nature of nuclear war, this treatise examines human reaction to nuclear disaster and accidental explosions. The discussion is based on evidence of human fallibility that has emerged from the psychology of accidents and from research into decision-making in military and political contexts. The book draws on the psychology of negotiation and conflict resolution to suggest ways in which the threat of nuclear war might be reduced.

  3. High School Weight Training: A Comprehensive Program.

    ERIC Educational Resources Information Center

    Viscounte, Roger; Long, Ken

    1989-01-01

    Describes a weight training program, suitable for the general student population and the student-athlete, which is designed to produce improvement in specific, measurable areas including bench press (upper body), leg press (lower body), vertical jump (explosiveness); and 40-yard dash (speed). Two detailed charts are included, with notes on their…

  4. The Urban Explosion. Draper Fund Report No. 10.

    ERIC Educational Resources Information Center

    Camp, Sharon L., Ed.; And Others

    This booklet contains reports presented by delegates from Mexico, Egypt, China, Bangladesh, Italy, the Philippines, Zaire, and Indonesia to the International Conference on Population and the Urban Future held in Rome, Italy, on September 1-4, 1980. An introductory statement by the Executive Director of the United Nations Fund for Population…

  5. Essays on the Future of Continuing Education Worldwide.

    ERIC Educational Resources Information Center

    Ziegler, Warren L., Ed.

    Topics chosen for these eight seminar papers divide basically into three categories: discussions on processes and methods for planning for the future of adult education; attempts to project into the future such worldwide problems as urbanism, conflict, the population explosion, and specific adult education trends; and discussion of the current…

  6. Pollution Probe.

    ERIC Educational Resources Information Center

    Chant, Donald A.

    This book is written as a statement of concern about pollution by members of Pollution Probe, a citizens' anti-pollution group in Canada. Its purpose is to create public awareness and pressure for the eventual solution to pollution problems. The need for effective government policies to control the population explosion, conserve natural resources,…

  7. Enhancing the microbial population within poultry

    USDA-ARS?s Scientific Manuscript database

    Recent research advances have led to an explosion in information on the composition and impact of the microbiome on health and productivity that is nothing short of revolutionary. The accelerating rate of discoveries is dizzying, and we see in a way that we never could before the importance of the ...

  8. Hunger, A Scientists' Institute for Public Information Workbook.

    ERIC Educational Resources Information Center

    Mead, Margaret

    The first section of this workbook gives data on hunger and malnutrition in the United States, and outlines immediate community and national action needed to meet the emergency and provide against its recurrence. The second section discusses problems of world food supply, spreading technology, the population explosion, and the handling of…

  9. Significance of Life Skills Education

    ERIC Educational Resources Information Center

    Prajapati, Ravindra K.; Sharma, Bosky; Sharma, Dharmendra

    2017-01-01

    Adolescence is a period when the intellectual, physical, social, emotional and all the capabilities are very high, but, unfortunately, most of the adolescents are unable to utilize their potential to maximum due to various reasons. They face many emerging issues such as global warming, famines, poverty, suicide, population explosion as well as…

  10. OUR SOCIETY'S FUTURE--IMPLICATIONS FOR THE ADMINISTRATION OF EXTENSION PROGRAMS.

    ERIC Educational Resources Information Center

    GRIFFITH, WILLIAM S.

    IN AN ADDRESS THE AUTHOR STATES THAT THE POPULATION EXPLOSION VERSUS WORLD FOOD PRODUCTION CAPACITY, TOGETHER WITH URBAN BLIGHT, POVERTY, AND FUNCTIONAL ILLITERACY, INCREASING COMPETITION FOR TRAINED MANPOWER, AND RELATED IMBALANCES IN AMERICAN EDUCATION CONSTITUTE MAJOR TRENDS AND ACUTE PROBLEMS IN TODAY'S SOCIETY. THE AUTHOR FEELS UNIVERSITIES…

  11. Globalism and Health

    ERIC Educational Resources Information Center

    Rowland, Michael L.

    2011-01-01

    With the advent of twenty-four-hour news media, local, state, and national agencies' warnings and with the explosive role of the Internet, people are more aware of global health concerns that may have significant consequences for the world's population. As international travel continues to increase, health care professionals around the world are…

  12. Wound ballistics and blast injuries.

    PubMed

    Prat, N J; Daban, J-L; Voiglio, E J; Rongieras, F

    2017-12-01

    Wounds due to gunshot and explosions, while usually observed during battlefield combat, are no longer an exceptional occurrence in civilian practice in France. The principles of wound ballistics are based on the interaction between the projectile and the human body as well as the transfer of energy from the projectile to tissues. The treatment of ballistic wounds relies on several principles: extremity wound debridement and absence of initial closure, complementary medical treatment, routine immobilization, revision surgery and secondary closure. Victims of explosions usually present with a complex clinical picture since injuries are directly or indirectly related to the shock wave (blast) originating from the explosion. These injuries depend on the type of explosive device, the environment and the situation of the victim at the time of the explosion, and are classed as primary, secondary, tertiary or quaternary. Secondary injuries due to flying debris and bomb fragments are generally the predominant presenting symptoms while isolated primary injuries (blast) are rare. The resulting complexity of the clinical picture explains why triage of these victims is particularly difficult. Certain myths, such as inevitable necrosis of the soft tissues that are displaced by the formation of the temporary cavitation by the projectile, or sterilization of the wounds by heat generated by the projectile should be forgotten. Ballistic-protective body armor and helmets are not infallible, even when they are not perforated, and can even be at the origin of injuries, either due to missile impact, or to the blast. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  13. 49 CFR 176.194 - Stowage of Class 1 (explosive) materials on magazine vessels.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... coming on board unless it is necessary to abate a hazard to human life or a substantial hazard to... vessel must be equipped with a work boat. (r) Life preservers. One approved personal flotation device...

  14. 49 CFR 176.194 - Stowage of Class 1 (explosive) materials on magazine vessels.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... coming on board unless it is necessary to abate a hazard to human life or a substantial hazard to... vessel must be equipped with a work boat. (r) Life preservers. One approved personal flotation device...

  15. Volcanic suppression of Nile summer flooding triggers revolt and constrains interstate conflict in ancient Egypt.

    PubMed

    Manning, Joseph G; Ludlow, Francis; Stine, Alexander R; Boos, William R; Sigl, Michael; Marlon, Jennifer R

    2017-10-17

    Volcanic eruptions provide tests of human and natural system sensitivity to abrupt shocks because their repeated occurrence allows the identification of systematic relationships in the presence of random variability. Here we show a suppression of Nile summer flooding via the radiative and dynamical impacts of explosive volcanism on the African monsoon, using climate model output, ice-core-based volcanic forcing data, Nilometer measurements, and ancient Egyptian writings. We then examine the response of Ptolemaic Egypt (305-30 BCE), one of the best-documented ancient superpowers, to volcanically induced Nile suppression. Eruptions are associated with revolt onset against elite rule, and the cessation of Ptolemaic state warfare with their great rival, the Seleukid Empire. Eruptions are also followed by socioeconomic stress with increased hereditary land sales, and the issuance of priestly decrees to reinforce elite authority. Ptolemaic vulnerability to volcanic eruptions offers a caution for all monsoon-dependent agricultural regions, presently including 70% of world population.The degree to which human societies have responded to past climatic changes remains unclear. Here, using a novel combination of approaches, the authors show how volcanically-induced suppression of Nile summer flooding led to societal unrest in Ptolemaic Egypt (305-30 BCE).

  16. Gender apartheid and its impact on Indian women's reproductive health.

    PubMed

    Sarin, A R

    1992-01-01

    In India the 1991 census showed a declining sex ratio. The number of females was 929 per 1000 males compared to 934 in 1981. Early childhood mortality, malnutrition, high maternal mortality, and female feticide may all be contributing to this disturbing trend. Only 39.42% of women are literate compared to 63.86% of males. At least 50% of women suffer from anemia. Indian women face a 50-times higher rate of pregnancy- and delivery-related deaths than the women in the industrialized countries, a consequence of difficult access to health care, ignorance, poverty, and repeated and close pregnancies. Reproductive tract infections (RTIs) are common with outcomes such as ectopic pregnancy, infertility, and chronic pelvic pain. Also, cervical cancer is still a major killer of Indian women. Another area of concern is the population explosion. Overpopulation brings malnourished and dying children, slums, unemployment, deforestation, desertification and an unending cycle of poverty, illiteracy, and disease. India's population has reached 862 million, and according to the 1991 census there has been an increase of 23.5% during the past decade. India's annual population growth rate of 2.11% is only marginally less than the 2.23% of the preceding decade. The density of population has increased to 267 per square km compared to 216 in 1981. At the present rate of growth, the population by the turn of the century would reach 1 billion. Perhaps the real cause of failing to halt the galloping population growth is related to different human rights standards for men and women. Society accepts that men have the ultimate say when it comes to family planning and determining the size of the family. The medical profession can be an instrument of change, especially in regard to women's health related to wider sociological, cultural, historical, and economic issues.

  17. What Effect Will America’s Elderly Have on National Security in the Year 2010

    DTIC Science & Technology

    1991-05-09

    greater number of years is becoming more important to the aging population.L4 The Income Profile of the Elderly The median income for older persons in...implications. ii INTRODUCTION Is it too late capitalize on the silver-haired population explosion? Today’s older adults are living longer than any other time...before in the history of America. Senior citizens’ increased life-span is linked to greater health consciousness and more physical activity. Equally

  18. GENETIC-BASED ANALYTICAL METHODS FOR BACTERIA AND FUNGI

    EPA Science Inventory

    In the past two decades, advances in high-throughput sequencing technologies have lead to a veritable explosion in the generation of nucleic acid sequence information (1). While these advances are illustrated most prominently by the successful sequencing of the human genome, they...

  19. Potential Mechanisms for Enhanced Zika Epidemic and Disease.

    PubMed

    Xia, Hongjie; Xie, Xuping; Shan, Chao; Shi, Pei-Yong

    2018-05-11

    A number of mechanisms have driven the explosive epidemics and severe diseases of Zika virus since 2007. Here, we comment on how herd immunity, heterologous flavivirus preimmunity, and viral mutations could enhance the epidemic potential and disease severity of Zika virus in humans.

  20. 77 FR 71787 - Agency Information Collection Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-04

    ... annual supervisory review, medical assessment, management evaluation, and a DOE personnel security review... explosive duties do not have emotional, mental, or physical conditions that could result in an accidental or.... 1910-5122; (2) Information Collection Request Title: Human Reliability Program; (3) Type of Review...

  1. 40 CFR 307.22 - Preauthorization of response actions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS COMPREHENSIVE ENVIRONMENTAL RESPONSE, COMPENSATION...), if there is acute threat of fire, explosion, or direct human contact with hazardous substances... innovative technology, if appropriate; (7) Employs treatment that reduces the volume, toxicity or mobility of...

  2. Handler beliefs affect scent detection dog outcomes.

    PubMed

    Lit, Lisa; Schweitzer, Julie B; Oberbauer, Anita M

    2011-05-01

    Our aim was to evaluate how human beliefs affect working dog outcomes in an applied environment. We asked whether beliefs of scent detection dog handlers affect team performance and evaluated relative importance of human versus dog influences on handlers' beliefs. Eighteen drug and/or explosive detection dog/handler teams each completed two sets of four brief search scenarios (conditions). Handlers were falsely told that two conditions contained a paper marking scent location (human influence). Two conditions contained decoy scents (food/toy) to encourage dog interest in a false location (dog influence). Conditions were (1) control; (2) paper marker; (3) decoy scent; and (4) paper marker at decoy scent. No conditions contained drug or explosive scent; any alerting response was incorrect. A repeated measures analysis of variance was used with search condition as the independent variable and number of alerts as the dependent variable. Additional nonparametric tests compared human and dog influence. There were 225 incorrect responses, with no differences in mean responses across conditions. Response patterns differed by condition. There were more correct (no alert responses) searches in conditions without markers. Within marked conditions, handlers reported that dogs alerted more at marked locations than other locations. Handlers' beliefs that scent was present potentiated handler identification of detection dog alerts. Human more than dog influences affected alert locations. This confirms that handler beliefs affect outcomes of scent detection dog deployments.

  3. Mechanisms of Cytotoxicity of the Aids Virus

    DTIC Science & Technology

    1992-10-10

    viruses such as Epstein - Barr virus , HTLV- formation between infected and uninfected cells. Pen- I, cytomegalovirus, hepatitis B virus , human herpes...therapeutic maneuvers which may suppress virus replication and/or cytopathicity, and assist in the development of a vaccine for HIV prevention. 7 Viral...infection of B cells with Epstein - Barr virus or (HIV-1) and explosive escape from an isolated human infection of other cell types with HTLV-l increases

  4. Characteristics of radionuclide contamination of different zones of Semipalatinsk Nuclear Test Site ``Opytnoe pole''

    NASA Astrophysics Data System (ADS)

    Kadyrzhanov, K. K.; Khazhekber, S.; Lukashenko, S. N.; Solodukhin, V. P.; Kazachevskiy, I. V.; Poznyak, V. L.; Knyazev, B. B.; Rofer, Ch.

    2003-01-01

    Data on the spatial distribution of radionuclides (241Am, 239Pu, 137Cs and 152Eu) formed during nuclear explosions of different types near P2 SNTS test site are presented. Radionuclide contamination induced by the explosions varies in the concentrations of individual radionuclides, their proportions and species. Examination of the variations is a crucial task to plan remediation activities as well as those aimed at decrease of radiation risk for population and prevention of repeated contamination. Concentrations of 241Am and 239+240Pu that are the most toxic radionuclides in the area lie in hundred thousands of Bqkg-1. The most contaminated areas are classified by the radionuclide concentration, ratio and form present in soil.

  5. Source mechanisms of volcanic tsunamis.

    PubMed

    Paris, Raphaël

    2015-10-28

    Volcanic tsunamis are generated by a variety of mechanisms, including volcano-tectonic earthquakes, slope instabilities, pyroclastic flows, underwater explosions, shock waves and caldera collapse. In this review, we focus on the lessons that can be learnt from past events and address the influence of parameters such as volume flux of mass flows, explosion energy or duration of caldera collapse on tsunami generation. The diversity of waves in terms of amplitude, period, form, dispersion, etc. poses difficulties for integration and harmonization of sources to be used for numerical models and probabilistic tsunami hazard maps. In many cases, monitoring and warning of volcanic tsunamis remain challenging (further technical and scientific developments being necessary) and must be coupled with policies of population preparedness. © 2015 The Author(s).

  6. Resolved Host Studies of Stellar Explosions

    NASA Astrophysics Data System (ADS)

    Levesque, Emily M.

    The host galaxies of nearby (z<0.3) core-collapse supernovae and long-duration gamma-ray bursts offer an excellent means of probing the environments and populations that produce these events' varied massive progenitors. These same young stellar progenitors make LGRBs and SNe valuable and potentially powerful tracers of star formation, metallicity, the IMF, and the end phases of stellar evolution. However, properly utilizing these progenitors as tools requires a thorough understanding of their formation and, consequently, the physical properties of their parent host environments. In this talk I will review some of the recent work on LGRB and SN hosts with resolved environments that allows us to probe the precise explosion sites and surrounding environments of these events in incredible detail.

  7. The Young Massive Stellar Cluster Sandage-96 after the Explosion of SN 2004DJ in NGC 2403

    NASA Technical Reports Server (NTRS)

    Vinko, J.; Sarneczky, K.; Balog, Z.; Immler, S.; Sugerman, B.; Brown, P. J.; Misselt, K.; Szabo, Gy. M.; Klagyivik, P.; Kun, M.; hide

    2008-01-01

    The bright supernova 2004dj occurred within the young massive stellar cluster Sandage-96 in a spiral arm of NGC 2403, close to other star-forming complexes. New multi-wavelength observations obtained with several ground-based- and space telescopes are combined to study the radiation from Sandage-96 after SN 2004dj faded away. The late-time light curves show that Sandage-96 started to dominate the flux in the optical bands after September, 2006 (+800 days after explosion). The optical fluxes are equal to the pre-explosion ones, suggesting that Sandage-96 has survived the explosion without significant changes in its stellar population. An optical Keck-spectrum obtained at +900 days after explosion shows the dominant blue continuum from the cluster stars shortward of 6000 A as well as strong SN nebular emission lines redward. The integrated SED of the cluster has been extended into the UV-region by archival XMM-Newton and new Swift observations, and compared with theoretical models. The outer parts of the cluster have been resolved by HST allowing the construction of a color-magnitude diagram. The fitting of the cluster SED with theoretical isochrones results in two possible solutions with ages being 9+/-1 Myr and 30+/-10 Myr, depending on the assumed metallicity and the theoretical model family. The isochrone fitting of the color-magnitude diagram indicates that the outer part of the cluster consists of stars having an age dispersion of 16 < t < 63 Myr, which is similar to that of nearby field stars. This age discrepancy may be resolved by the hypothesis that the outskirt of Sandage-96 is contaminated by stars captured from the field during cluster formation. The young age of Sandage-96 and the comparison of its pre- and post-explosion SEDs suggest a progenitor mass of 15 < or equal to M(sub prog) < 25 Stellar Mass.

  8. Predator interference effects on biological control: The "paradox" of the generalist predator revisited

    NASA Astrophysics Data System (ADS)

    Parshad, Rana D.; Bhowmick, Suman; Quansah, Emmanuel; Basheer, Aladeen; Upadhyay, Ranjit Kumar

    2016-10-01

    An interesting conundrum in biological control questions the efficiency of generalist predators as biological control agents. Theory suggests, generalist predators are poor agents for biological control, primarily due to mutual interference. However field evidence shows they are actually quite effective in regulating pest densities. In this work we provide a plausible answer to this paradox. We analyze a three species model, where a generalist top predator is introduced into an ecosystem as a biological control, to check the population of a middle predator, that in turn is depredating on a prey species. We show that the inclusion of predator interference alone, can cause the solution of the top predator equation to blow-up in finite time, while there is global existence in the no interference case. This result shows that interference could actually cause a population explosion of the top predator, enabling it to control the target species, thus corroborating recent field evidence. Our results might also partially explain the population explosion of certain species, introduced originally for biological control purposes, such as the cane toad (Bufo marinus) in Australia, which now functions as a generalist top predator. We also show both Turing instability and spatio-temporal chaos in the model. Lastly we investigate time delay effects.

  9. Mitigation of Earth-asteroid collisions via explosive, intense radiation sources

    NASA Astrophysics Data System (ADS)

    Miles, Aaron; Sanders, James

    2005-10-01

    The Universe is continually producing astrophysical explosions that generate intense bursts of electromagnetic and particle radiation. Interaction of this radiation with nearby objects can effect significant changes to their dynamics through a variety of processes including ionization, ablation, and shock generation. The next time a large asteroid or comet is found to be approaching the Earth on an impact trajectory, humans may find it prudent to mimic nature by using the most intense radiation sources available to alter the incoming object's trajectory and avert a catastrophic collision. With this in mind, we consider the effect of nuclear explosives on nearby would-be Earth impactors. Neutrons and x-rays produced in the explosion are deposited in a thin layer of the asteroid's surface, resulting in ablation and shock and thereby imparting a deflection velocity. A Monte Carlo code is used for radiation transport and energy deposition, while the subsequent dynamic evolution of the asteroid is followed with the hydrodynamics code CALE. We consider the dependence of the deflection velocity on the source energy and spectrum, the asteroid or comet composition, and the standoff distance between the target and the source. This work was performed under the auspices of the U. S. Department of Energy by the University of California, Lawrence Livermore National Laboratory under contract No. W-7405-Eng-48.

  10. Early Leakage Protection System of LPG (Liquefied Petroleum Gas) Based on ATMega 16 Microcontroller

    NASA Astrophysics Data System (ADS)

    Sriwati; Ikhsan Ilahi, Nur; Musrawati; Baco, Syarifuddin; Suyuti'Andani Achmad, Ansar; Umrianah, Ejah

    2018-04-01

    LPG (Liquefied Petroleum Gas). LPG is a hydrocarbon gas production from refineries and gas refinery with the major components of propane gas (C3H8) and butane (C4H10). Limit flame (Flammable Range) or also called gas with air. Value Lower Explosive Limit (LEL) is the minimum limit of the concentration of fuel vapor in the air which if there is no source of fire, the gas will be burned. While the value of the Upper Explosive Limit (UEL), which limits the maximum concentration of fuel vapor in the air, which if no source of fire, the gas will be burned. Protection system is a defend mechanism of human, equipment, and buildings around the protected area. Goals to be achieved in this research are to design a protection system against the consequences caused by the leakage of LPG gas based on ATmega16 microcontroller. The method used in this research is to reduce the levels of leaked LPG and turned off the power source when the leakage of LPG is on the verge of explosive limit. The design of this protection system works accurately between 200 ppm up to 10000 ppm, which is still below the threshold of explosive. Thus protecting the early result of that will result in the leakage of LPG gas.

  11. Human health risks related to the consumption of foodstuffs of plant and animal origin produced on a site polluted by chemical munitions of the First World War.

    PubMed

    Gorecki, Sébastien; Nesslany, Fabrice; Hubé, Daniel; Mullot, Jean-Ulrich; Vasseur, Paule; Marchioni, Eric; Camel, Valérie; Noël, Laurent; Le Bizec, Bruno; Guérin, Thierry; Feidt, Cyril; Archer, Xavier; Mahe, Aurélie; Rivière, Gilles

    2017-12-01

    Shells fired during World War I exhibited different explosive compounds and some of these weapons also contained a wide variety of chemical warfare agents. At the end of the war, for safety purposes, the large quantity of weapons remaining on the former front needed to be dismantled and destroyed. A large amount of the remaining shells was destroyed in specific sites which led to the contamination of the surroundings in Belgium and France. In the 1920s, 1.5 million chemical shells and 30,000 explosive shells were destroyed in a place close to the city of Verdun, in the East of France. In this paper, the risk for human health related to the consumption of foodstuffs produced on this site was assessed. To this end, food products of plant and animal origin were sampled in 2015-2016 and contaminant analyses were conducted. Human exposure was assessed using a specifically built methodology. The contaminants considered in this study were trace elements (TEs - primarily Zn, As, Pb and Cd), nitroaromatic explosives (trinitrotoluene, 2,4-dinitrotoluene, 2,6-dinitrotoluene, 2-amino-4,6-dinitroluene and 4-amino-2,6-dinitrotoluene), phenylarsenic compounds including diphenylarsinic acid and triphenylarsine, perchlorate, tetrabromoethane and vinyl bromide. Depending on the compound, different approaches were used to assess the risk for both adults and children. Exposure to these contaminants through the consumption of foodstuffs produced locally on the considered site was unlikely to be a health concern. However, as for inorganic arsenic, given the presence of highly contaminated zones, it was suggested that cereals should not be grown on certain plots. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. Christa McAuliffe runs in place on a treadmill to test physiological response

    NASA Image and Video Library

    1985-07-12

    S85-37165 (8-12 July 1985) -- Sharon C. (Christa) McAuliffe of Concord High, Concord, New Hampshire, runs in place on treadmill to test physiological responses at Johnson Space Center. Christa McAuliffe was eventually chosen as the first Teacher in Space and was a member of the seven-member Challenger shuttle crew which died tragically in the explosion of the spacecraft during the launch of STS-51L from the Kennedy Space Center about 11:40 a.m., EST, on Jan. 28, 1986. The explosion occurred 73 seconds into the flight as a result of a leak in one of two Solid Rocket Boosters that ignited the main liquid fuel tank. The crew members of the Challenger represented a cross-section of the American population in terms of race, gender, geography, background, and religion. The explosion became one of the most significant events of the 1980s, as billions around the world saw the accident on television and empathized with any one of the several crew members killed. Photo credit: NASA

  13. Casual view of Christa McAuliffe during training for STS 51-L

    NASA Image and Video Library

    1985-07-23

    S85-37677 (8-12 July 1985) --- Sharon C. (Christa) McAuliffe of Concord High, Concord, New Hampshire, talks to nurse during physiological testing on first day at Johnson Space Center (JSC). Christa McAuliffe was eventually chosen as the first Teacher in Space and was a member of the seven-member Challenger shuttle crew which died tragically in the explosion of the spacecraft during the launch of STS-51L from the Kennedy Space Center about 11:40 a.m., EST, on Jan. 28, 1986. The explosion occurred 73 seconds into the flight as a result of a leak in one of two Solid Rocket Boosters that ignited the main liquid fuel tank. The crew members of the Challenger represented a cross-section of the American population in terms of race, gender, geography, background, and religion. The explosion became one of the most significant events of the 1980s, as billions around the world saw the accident on television and empathized with any one of the several crew members killed. Photo credit: NASA

  14. The contribution of sting-jet windstorms to extreme wind risk in the North Atlantic

    NASA Astrophysics Data System (ADS)

    Hart, Neil C.; Gray, Suzanne L.; Clark, Peter A.

    2016-04-01

    Windstorms are a major winter weather risk for many countries in Europe. These storms are predominantly associated with explosively-developing extratropical cyclones that track across the region. A substantial body of literature exists on the synoptic-scale dynamics, predictability and climatology of such storms. More recently, interest in the mesoscale variability of the most damaging winds has led to a focus on the role of sting jets in enhancing windstorm severity. We present a present-era climatology of North Atlantic cyclones that had potential to produce sting jets. Considering only explosively-developing cyclones, those with sting-jet potential are more likely to have higher relative vorticity and associated low-level wind maxima. Furthermore, the strongest winds for sting-jet cyclones are more often in the cool sector, behind the cold front, when compared with other explosively-developing cyclones which commonly have strong warm-sector winds too. The tracks of sting-jet cyclones, and explosively-developing cyclones in general, show little offset from the climatological storm track. While rare over Europe, sting-jet cyclones are relatively frequent within the main storm track with up to one third of extratropical cyclones exhibiting sting-jet potential. Thus, the rarity and, until recently, lack of description of sting-jet windstorms is more due to the climatological storm track location away from highly-populated land masses, than due to an actual rarity of such storms in nature.

  15. An upper limit on the contribution of accreting white dwarfs to the type Ia supernova rate.

    PubMed

    Gilfanov, Marat; Bogdán, Akos

    2010-02-18

    There is wide agreement that type Ia supernovae (used as standard candles for cosmology) are associated with the thermonuclear explosions of white dwarf stars. The nuclear runaway that leads to the explosion could start in a white dwarf gradually accumulating matter from a companion star until it reaches the Chandrasekhar limit, or could be triggered by the merger of two white dwarfs in a compact binary system. The X-ray signatures of these two possible paths are very different. Whereas no strong electromagnetic emission is expected in the merger scenario until shortly before the supernova, the white dwarf accreting material from the normal star becomes a source of copious X-rays for about 10(7) years before the explosion. This offers a means of determining which path dominates. Here we report that the observed X-ray flux from six nearby elliptical galaxies and galaxy bulges is a factor of approximately 30-50 less than predicted in the accretion scenario, based upon an estimate of the supernova rate from their K-band luminosities. We conclude that no more than about five per cent of type Ia supernovae in early-type galaxies can be produced by white dwarfs in accreting binary systems, unless their progenitors are much younger than the bulk of the stellar population in these galaxies, or explosions of sub-Chandrasekhar white dwarfs make a significant contribution to the supernova rate.

  16. Taking the Earth's Pulse

    USGS Publications Warehouse

    Woodward, Robert L.; Benz, Harley Mitchell; Shedlock, Kaye M.; Brown, William M.

    2000-01-01

    During the past 35 years, scientists have developed a vast network of seismometers that record earthquakes, volcanic eruptions, and nuclear explosions throughout the world. Seismographic data support disaster response, scientific research, and global security. With this network, the United States maintains world leadership in monitoring the greatest natural and technological events that threaten our planet's population.

  17. Taking the Earth's pulse

    USGS Publications Warehouse

    Woodward, Robert L.; Benz, Harly M.; Brown, William M.

    1997-01-01

    During the past 35 years, scientists have developed a vast network of seismometers that record earthquakes, volcanic eruptions, and nuclear explosions throughout the world. Seismographic data support disaster response, scientific research, and global security. With this network, the United States maintains world leadership in monitoring the greatest natural and technological events that threaten our planet's population.

  18. Education and the Population Explosion

    ERIC Educational Resources Information Center

    Van Tienhoven, A.; And Others

    1971-01-01

    Reports results of a questionnaire survey of Cornell undergraduates, graduate students, and faculty on knowledge and attitudes about methods of contraception. Concludes that our young have yet to learn all that needs to be known about the biology of sex and they remain yet to be persuaded of the need for reproductive restraint. (Authors/AL)

  19. Impacts of Urbanization on Flood and Soil Erosion Hazards in Istanbul, Turkey

    ERIC Educational Resources Information Center

    Ozacar, Biricik Gozde

    2013-01-01

    Due to the inappropriate planning and explosive population growth in urban areas, especially in developing countries, sustainable and disaster-safe urbanization has become the most important challenge for governments. Urbanization presents benefits in different ways but has led simultaneously to changes in land use/land cover (LULC), impacting…

  20. Youth Unemployment--Time to Do Something About It.

    ERIC Educational Resources Information Center

    Department of Labor, Washington, DC.

    Presented in this summary document are 17 charts and statements concerning youth unemployment. Topics covered include: (1) the ratio of teenage to adult unemployment rates, (2) the population explosion, (3) effects of staying in school, (4) state minimum wage patterns, and (5) the effects of a differential on family income. A recommended course of…

  1. Foreign Internal Defense

    DTIC Science & Technology

    2010-07-12

    leaders. (h) Former political leaders or retired government officials. (i) Tribal or family leaders. (j) Agricultural leaders, farmers ...logistics sustainability overlay depicts potable water supplies, farms, orchards , growing seasons, and other relevant items. In built-up areas, this...explosives, and population patterns such as seasonal employment. Examples of potential effects are periods of drought that force farmers to become

  2. Guide to Using Onionskin Analysis Code (U)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fugate, Michael Lynn; Morzinski, Jerome Arthur

    2016-09-15

    This document is a guide to using R-code written for the purpose of analyzing onionskin experiments. We expect the user to be very familiar with statistical methods and the R programming language. For more details about onionskin experiments and the statistical methods mentioned in this document see Storlie, Fugate, et al. (2013). Engineers at LANL experiment with detonators and high explosives to assess performance. The experimental unit, called an onionskin, is a hemisphere consisting of a detonator and a booster pellet surrounded by explosive material. When the detonator explodes, a streak camera mounted above the pole of the hemisphere recordsmore » when the shock wave arrives at the surface. The output from the camera is a two-dimensional image that is transformed into a curve that shows the arrival time as a function of polar angle. The statistical challenge is to characterize a baseline population of arrival time curves and to compare the baseline curves to curves from a new, so-called, test series. The hope is that the new test series of curves is statistically similar to the baseline population.« less

  3. Probing the stellar initial mass function with high-z supernovae

    NASA Astrophysics Data System (ADS)

    de Souza, R. S.; Ishida, E. E. O.; Whalen, D. J.; Johnson, J. L.; Ferrara, A.

    2014-08-01

    The first supernovae (SNe) will soon be visible at the edge of the observable universe, revealing the birthplaces of Population III stars. With upcoming near-infrared missions, a broad analysis of the detectability of high-z SNe is paramount. We combine cosmological and radiation transport simulations, instrument specifications and survey strategies to create synthetic observations of primeval core-collapse (CC), Type IIn and pair-instability (PI) SNe with the James Webb Space Telescope (JWST). We show that a dedicated observational campaign with the JWST can detect up to ˜15 PI explosions, ˜300 CC SNe, but less than one Type IIn explosion per year, depending on the Population III star formation history. Our synthetic survey also shows that ≈1-2 × 102 SNe detections, depending on the accuracy of the classification, are sufficient to discriminate between a Salpeter and flat mass distribution for high-redshift stars with a confidence level greater than 99.5 per cent. We discuss how the purity of the sample affects our results and how supervised learning methods may help to discriminate between CC and PI SNe.

  4. High-fat diet and maternal obesity-associated epigenetic regulation of bone development

    USDA-ARS?s Scientific Manuscript database

    Due to the worldwide epidemic in obesity, maternal obesity has recently seen an explosion in investigations in both animal models and humans on its effects on offspring phenotype and pathologies including diabetes, hyperlipidemia, cardiovascular disease, and cancer. Epigenetic mechanisms presumably ...

  5. How Can We Use Bioinformatics to Predict Which Agents Will Cause Birth Defects?

    EPA Science Inventory

    The availability of genomic sequences from a growing number of human and model organisms has provided an explosion of data, information, and knowledge regarding biological systems and disease processes. High-throughput technologies such as DNA and protein microarray biochips are ...

  6. Agricultural intensification, priming for persistence and the emergence of Nipah virus: a lethal bat-borne zoonosis

    PubMed Central

    Pulliam, Juliet R. C.; Epstein, Jonathan H.; Dushoff, Jonathan; Rahman, Sohayati A.; Bunning, Michel; Jamaluddin, Aziz A.; Hyatt, Alex D.; Field, Hume E.; Dobson, Andrew P.; Daszak, Peter

    2012-01-01

    Emerging zoonoses threaten global health, yet the processes by which they emerge are complex and poorly understood. Nipah virus (NiV) is an important threat owing to its broad host and geographical range, high case fatality, potential for human-to-human transmission and lack of effective prevention or therapies. Here, we investigate the origin of the first identified outbreak of NiV encephalitis in Malaysia and Singapore. We analyse data on livestock production from the index site (a commercial pig farm in Malaysia) prior to and during the outbreak, on Malaysian agricultural production, and from surveys of NiV's wildlife reservoir (flying foxes). Our analyses suggest that repeated introduction of NiV from wildlife changed infection dynamics in pigs. Initial viral introduction produced an explosive epizootic that drove itself to extinction but primed the population for enzootic persistence upon reintroduction of the virus. The resultant within-farm persistence permitted regional spread and increased the number of human infections. This study refutes an earlier hypothesis that anomalous El Niño Southern Oscillation-related climatic conditions drove emergence and suggests that priming for persistence drove the emergence of a novel zoonotic pathogen. Thus, we provide empirical evidence for a causative mechanism previously proposed as a precursor to widespread infection with H5N1 avian influenza and other emerging pathogens. PMID:21632614

  7. Agricultural intensification, priming for persistence and the emergence of Nipah virus: a lethal bat-borne zoonosis.

    PubMed

    Pulliam, Juliet R C; Epstein, Jonathan H; Dushoff, Jonathan; Rahman, Sohayati A; Bunning, Michel; Jamaluddin, Aziz A; Hyatt, Alex D; Field, Hume E; Dobson, Andrew P; Daszak, Peter

    2012-01-07

    Emerging zoonoses threaten global health, yet the processes by which they emerge are complex and poorly understood. Nipah virus (NiV) is an important threat owing to its broad host and geographical range, high case fatality, potential for human-to-human transmission and lack of effective prevention or therapies. Here, we investigate the origin of the first identified outbreak of NiV encephalitis in Malaysia and Singapore. We analyse data on livestock production from the index site (a commercial pig farm in Malaysia) prior to and during the outbreak, on Malaysian agricultural production, and from surveys of NiV's wildlife reservoir (flying foxes). Our analyses suggest that repeated introduction of NiV from wildlife changed infection dynamics in pigs. Initial viral introduction produced an explosive epizootic that drove itself to extinction but primed the population for enzootic persistence upon reintroduction of the virus. The resultant within-farm persistence permitted regional spread and increased the number of human infections. This study refutes an earlier hypothesis that anomalous El Niño Southern Oscillation-related climatic conditions drove emergence and suggests that priming for persistence drove the emergence of a novel zoonotic pathogen. Thus, we provide empirical evidence for a causative mechanism previously proposed as a precursor to widespread infection with H5N1 avian influenza and other emerging pathogens.

  8. Neutron Star Kicks by the Gravitational Tug-boat Mechanism in Asymmetric Supernova Explosions: Progenitor and Explosion Dependence

    NASA Astrophysics Data System (ADS)

    Janka, Hans-Thomas

    2017-03-01

    Asymmetric mass ejection in the early phase of supernova (SN) explosions can impart a kick velocity to the new-born neutron star (NS). For neutrino-driven explosions the NS acceleration has been shown to be mainly caused by the gravitational attraction of the anisotropically expelled inner ejecta, while hydrodynamic forces contribute on a subdominant level, and asymmetric neutrino emission plays only a secondary role. Two- and three-dimensional hydrodynamic simulations have demonstrated that this gravitational tug-boat mechanism can explain the observed space velocities of young NSs up to more than 1000 km s-1. Here, we discuss how the NS kick depends on the energy, ejecta mass, and asymmetry of the SN explosion, and what role the compactness of the pre-collapse stellar core plays for the momentum transfer to the NS. We also provide simple analytic expressions for the NS velocity in terms of these quantities. Referring to results of hydrodynamic simulations in the literature, we argue why, within the discussed scenario of NS acceleration, electron-capture SNe, low-mass Fe-core SNe, and ultra-stripped SNe can be expected to have considerably lower intrinsic NS kicks than core-collapse SNe of massive stellar cores. Our basic arguments also remain valid if progenitor stars possess large-scale asymmetries in their convective silicon and oxygen burning layers. Possible scenarios for spin-kick alignment are sketched. Much of our discussion stays on a conceptual and qualitative level, and more work is necessary on the numerical modeling side to determine the dependences of involved parameters, whose prescriptions will be needed for recipes that can be used to better describe NS kicks in binary evolution and population synthesis studies.

  9. Neutron Star Kicks by the Gravitational Tug-boat Mechanism in Asymmetric Supernova Explosions: Progenitor and Explosion Dependence

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Janka, Hans-Thomas

    Asymmetric mass ejection in the early phase of supernova (SN) explosions can impart a kick velocity to the new-born neutron star (NS). For neutrino-driven explosions the NS acceleration has been shown to be mainly caused by the gravitational attraction of the anisotropically expelled inner ejecta, while hydrodynamic forces contribute on a subdominant level, and asymmetric neutrino emission plays only a secondary role. Two- and three-dimensional hydrodynamic simulations have demonstrated that this gravitational tug-boat mechanism can explain the observed space velocities of young NSs up to more than 1000 km s{sup −1}. Here, we discuss how the NS kick depends onmore » the energy, ejecta mass, and asymmetry of the SN explosion, and what role the compactness of the pre-collapse stellar core plays for the momentum transfer to the NS. We also provide simple analytic expressions for the NS velocity in terms of these quantities. Referring to results of hydrodynamic simulations in the literature, we argue why, within the discussed scenario of NS acceleration, electron-capture SNe, low-mass Fe-core SNe, and ultra-stripped SNe can be expected to have considerably lower intrinsic NS kicks than core-collapse SNe of massive stellar cores. Our basic arguments also remain valid if progenitor stars possess large-scale asymmetries in their convective silicon and oxygen burning layers. Possible scenarios for spin-kick alignment are sketched. Much of our discussion stays on a conceptual and qualitative level, and more work is necessary on the numerical modeling side to determine the dependences of involved parameters, whose prescriptions will be needed for recipes that can be used to better describe NS kicks in binary evolution and population synthesis studies.« less

  10. Identifying a combined construct of grief and explosive anger as a response to injustice amongst survivors of mass conflict: A latent class analysis of data from Timor-Leste.

    PubMed

    Rees, Susan J; Tay, Alvin Kuowei; Savio, Elisa; Maria Da Costa, Zelia; Silove, Derrick

    2017-01-01

    Previous studies have identified high rates of explosive anger amongst post-conflict populations including Timor-Leste. We sought to test whether explosive anger was integrally associated with symptoms of grief amongst the Timorese, a society that has experienced extensive conflict-related losses. In 2010 and 2011 we recruited adults (n = 2964), 18-years and older, living in an urban and a rural village in Timor-Leste. We applied latent class analysis to identify subpopulations based on symptoms of explosive anger and grief. The best fitting model comprised three classes: grief (24%), grief-anger (25%), and a low symptom group (51%). There were more women and urban dwellers in the grief and grief-anger classes compared to the reference class. Persons in the grief and grief-anger classes experienced higher rates of witnessing murder and atrocities and traumatic losses, ongoing poverty, and preoccupations with injustice for the two historical periods of conflict (the Indonesian occupation and the later internal conflict). Compared to the reference class, only the grief-anger class reported greater exposure to extreme deprivations during the conflict, ongoing family conflict, and preoccupations with injustice for contemporary times; and compared to the grief class, greater exposure to traumatic losses, poverty, family conflict and preoccupations with injustice for both the internal conflict and contemporary times. A substantial number of adults in this post-conflict country experienced a combined constellation of grief and explosive anger associated with extensive traumatic losses, deprivations, and preoccupations with injustice. Importantly, grief-anger may be linked to family conflict in this post-conflict environment.

  11. Identifying a combined construct of grief and explosive anger as a response to injustice amongst survivors of mass conflict: A latent class analysis of data from Timor-Leste

    PubMed Central

    Rees, Susan J.; Tay, Alvin Kuowei; Savio, Elisa; Maria Da Costa, Zelia; Silove, Derrick

    2017-01-01

    Previous studies have identified high rates of explosive anger amongst post-conflict populations including Timor-Leste. We sought to test whether explosive anger was integrally associated with symptoms of grief amongst the Timorese, a society that has experienced extensive conflict-related losses. In 2010 and 2011 we recruited adults (n = 2964), 18-years and older, living in an urban and a rural village in Timor-Leste. We applied latent class analysis to identify subpopulations based on symptoms of explosive anger and grief. The best fitting model comprised three classes: grief (24%), grief-anger (25%), and a low symptom group (51%). There were more women and urban dwellers in the grief and grief-anger classes compared to the reference class. Persons in the grief and grief-anger classes experienced higher rates of witnessing murder and atrocities and traumatic losses, ongoing poverty, and preoccupations with injustice for the two historical periods of conflict (the Indonesian occupation and the later internal conflict). Compared to the reference class, only the grief-anger class reported greater exposure to extreme deprivations during the conflict, ongoing family conflict, and preoccupations with injustice for contemporary times; and compared to the grief class, greater exposure to traumatic losses, poverty, family conflict and preoccupations with injustice for both the internal conflict and contemporary times. A substantial number of adults in this post-conflict country experienced a combined constellation of grief and explosive anger associated with extensive traumatic losses, deprivations, and preoccupations with injustice. Importantly, grief-anger may be linked to family conflict in this post-conflict environment. PMID:28430793

  12. Abundance profiling of extremely metal-poor stars and supernova properties in the early universe

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tominaga, Nozomu; Iwamoto, Nobuyuki; Nomoto, Ken'ichi, E-mail: tominaga@konan-u.ac.jp, E-mail: iwamoto.nobuyuki@jaea.go.jp, E-mail: nomoto@astron.s.u-tokyo.ac.jp

    2014-04-20

    After the big bang nucleosynthesis, the first heavy element enrichment in the universe was made by a supernova (SN) explosion of a population (Pop) III star (Pop III SN). The abundance ratios of elements produced from Pop III SNe are recorded in abundance patterns of extremely metal-poor (EMP) stars. The observations of the increasing number of EMP stars have made it possible to statistically constrain the explosion properties of Pop III SNe. We present Pop III SN models whose nucleosynthesis yields well reproduce, individually, the abundance patterns of 48 such metal-poor stars as [Fe/H] ≲ – 3.5. We then derivemore » relations between the abundance ratios of EMP stars and certain explosion properties of Pop III SNe: the higher [(C + N)/Fe] and [(C + N)/Mg] ratios correspond to the smaller ejected Fe mass and the larger compact remnant mass, respectively. Using these relations, the distributions of the abundance ratios of EMP stars are converted to those of the explosion properties of Pop III SNe. Such distributions are compared with those of the explosion properties of present day SNe: the distribution of the ejected Fe mass of Pop III SNe has the same peak as that of the present day SNe but shows an extended tail down to ∼10{sup –2}-10{sup –5} M {sub ☉}, and the distribution of the mass of the compact remnant of Pop III SNe is as wide as that of the present-day, stellar-mass black holes. Our results demonstrate the importance of large samples of EMP stars obtained by ongoing and future EMP star surveys and subsequent high-dispersion spectroscopic observations in clarifying the nature of Pop III SNe in the early universe.« less

  13. 49 CFR 172.522 - EXPLOSIVES 1.1, EXPLOSIVES 1.2 and EXPLOSIVES 1.3 placards.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false EXPLOSIVES 1.1, EXPLOSIVES 1.2 and EXPLOSIVES 1.3... INFORMATION, TRAINING REQUIREMENTS, AND SECURITY PLANS Placarding § 172.522 EXPLOSIVES 1.1, EXPLOSIVES 1.2 and EXPLOSIVES 1.3 placards. (a) Except for size and color, the EXPLOSIVES 1.1, EXPLOSIVES 1.2 and EXPLOSIVES 1.3...

  14. 49 CFR 172.522 - EXPLOSIVES 1.1, EXPLOSIVES 1.2 and EXPLOSIVES 1.3 placards.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false EXPLOSIVES 1.1, EXPLOSIVES 1.2 and EXPLOSIVES 1.3... INFORMATION, TRAINING REQUIREMENTS, AND SECURITY PLANS Placarding § 172.522 EXPLOSIVES 1.1, EXPLOSIVES 1.2 and EXPLOSIVES 1.3 placards. (a) Except for size and color, the EXPLOSIVES 1.1, EXPLOSIVES 1.2 and EXPLOSIVES 1.3...

  15. Improved mb-Ms Discrimination Using mb(P-coda) and MsU with Application to the Six North Korean Nuclear Tests

    NASA Astrophysics Data System (ADS)

    Napoli, V.; Yoo, S. H.; Russell, D. R.

    2017-12-01

    To improve discrimination of small explosions and earthquakes, we developed a new magnitude scale based on the standard Ms:mb discrimination method. In place of 20 second Ms measurements we developed a unified Rayleigh and Love wave magnitude scale (MsU) that is designed to maximize available information from single stations and then combine magnitude estimates into network averages. Additionally, in place of mb(P) measurements we developed an mb(P-Coda) magnitude scale as the properties of the coda make sparse network mb(P-Coda) more robust and less variable than network mb(P) estimates. A previous mb:MsU study conducted in 2013 in the Korean Peninsula shows that the use of MsU in place of standard 20 second Ms, leads to increased population separation and reduced scattering. The goals of a combined mb(P-coda):MsU scale are reducing scatter, ensuring applicability at small magnitudes with sparse networks, and improving the overall distribution for mb:Ms earthquake and explosion populations. To test this method we are calculating mb(P-coda)and MsU for a catalog earthquakes located in and near the Korean Peninsula, for the six North Korean nuclear tests (4.1 < mb < 6.3) and for the 3 aftershocks to date that occurred after the sixth test (2.6 < ML < 4.0). Compared to the previous 2013 study, we expect to see greater separation in the populations and less scattering with the inclusion of mb(P-coda) and with the implementation of additional filters for MsU to improve signal-to-noise levels; this includes S-transform filtering for polarization and off-azimuth signal reduction at regional distances. As we are expanding our database of mb(P-coda):MsU measurements in the Korean Peninsula to determine the earthquake and explosion distribution, this research will address the limitations and potential for discriminating small magnitude events using sparse networks.

  16. A mechanistic review on vermifiltration of wastewater: Design, operation and performance.

    PubMed

    Singh, Rajneesh; Bhunia, Puspendu; Dash, Rajesh R

    2017-07-15

    With global population explosion, the available water resources are slowly being polluted due to the excessive human interference. To encounter this, it is the need of this hour to find out sustainable pollution remediating technologies to meet the stringent discharge standards for domestic as well as industrial wastewaters. In addition, those techniques should have the capabilities for effective implementation even in developing countries. Based on the available literatures, one such technique, named vermifilter, has been identified which takes care of almost all the sustainable and economical criteria for its effective implementation even in developing countries. The aim of this meta-analysis is to provide a comprehensive review on assessment mechanisms involved, factors affecting the process and performance of vermifiltration under different scenarios. The present review envisages the current state of the knowledge regarding physical, chemical and biological aspects related to the treatment mechanisms and effective functioning of earthworms. This review has also proposed several suggestive plans on its application at any proposed site. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. Mediterranean Diet and Prevention of Chronic Diseases

    PubMed Central

    Romagnolo, Donato F.; Selmin, Ornella I.

    2017-01-01

    A large body of research data suggests that traditional dietary habits and lifestyle unique to the Mediterranean region (Mediterranean diet, MD) lower the incidence of chronic diseases and improve longevity. These data contrast with troubling statistics in the United States and other high income countries pointing to an increase in the incidence of chronic diseases and the projected explosion in cost of medical care associated with an aging population. In 2013, the MD was inscribed by UNESCO in the “Representative List of the Intangible Cultural Heritage of Humanity.” The 2015–2020 Dietary Guidelines for Americans included the MD as a healthy dietary pattern. Therefore, specific objectives of this article are to provide an overview of the nutritional basis of this healthful diet, its metabolic benefits, and its role in multiple aspects of disease prevention and healthy aging. Whereas recommendations about the MD often focus on specific foods or bioactive compounds, we suggest that the eating pattern as a whole likely contributes to the health promoting effects of the MD. PMID:29051674

  18. Pancreatic Cancer, Inflammation and Microbiome

    PubMed Central

    Zambirinis, Constantinos P.; Pushalkar, Smruti; Saxena, Deepak; Miller, George

    2014-01-01

    Pancreatic cancer is one of the most lethal cancers worldwide. No effective screening methods exist and available treatment modalities do not effectively treat the disease. Inflammatory conditions such as pancreatitis represent a well-known risk for pancreatic cancer development. Yet only in the past two decades has pancreatic cancer been recognized as an inflammation-driven cancer, and the precise mechanisms underlying the pathogenic role of inflammation are beginning to be explored in detail. A substantial amount of preclinical and clinical evidence suggests that bacteria are likely to influence this process by activating immune receptors and perpetuating cancer-associated inflammation. The recent explosion of investigations into the human microbiome have highlighted how perturbations of commensal bacterial populations can promote inflammation and promote disease processes, including carcinogenesis. The elucidation of the interplay between inflammation and microbiome in the context of pancreatic carcinogenesis will provide novel targets for intervention in order to both prevent and treat pancreatic cancer more efficiently. Further studies towards this direction are urgently needed. PMID:24855007

  19. Air pollution: a smoking gun for cancer.

    PubMed

    Zhang, Wei; Qian, Chao-Nan; Zeng, Yi-Xin

    2014-04-01

    Once considered a taboo topic or stigma, cancer is the number one public health enemy in the world. Once a product of an almost untouchable industry, tobacco is indisputably recognized as a major cause of cancer and a target for anticancer efforts. With the emergence of new economic powers in the world, especially in highly populated countries such as China, air pollution has rapidly emerged as a smoking gun for cancer and has become a hot topic for public health debate because of the complex political, economic, scientific, and technologic issues surrounding the air pollution problem. This editorial and the referred articles published in this special issue of the Chinese Journal of Cancer discuss these fundamental questions. Does air pollution cause a wide spectrum of cancers? Should air pollution be considered a necessary evil accompanying economic transformation in developing countries? Is an explosion of cancer incidence coming to China and how soon will it arrive? What must be done to prevent this possible human catastrophe? Finally, the approaches for air pollution control are also discussed.

  20. YouTube, Critical Pedagogy, and Media Activism

    ERIC Educational Resources Information Center

    Kellner, Douglas; Kim, Gooyong

    2010-01-01

    Critical pedagogy believes education to be a form of cultural politics that is fundamental to social transformation aiming to cultivate human agency and transformative activity. The explosion of information and communication technologies (ICTs) has provided ordinary people with unprecedented opportunities to take on the ruling educational power…

  1. Cry Havoc and Let Slip the Dogs of War

    DTIC Science & Technology

    2001-01-01

    disasters or other endemic conditions such as human pain, disease, hunger , or privation that might present a serious threat to life or that can result...1987. Weinstein, Sidney, Ph.D., et al., Neuropsychological Procedures for the Detection of Explosives, U.S. Army Mobility Equipment Research and

  2. Tiny plastic lung mimics human pulmonary function

    Science.gov Websites

    Los Alamos National Laboratory Search Site submit About Mission Business Newsroom Publications Los Innovation in New Mexico Los Alamos Collaboration for Explosives Detection (LACED) SensorNexus Exascale Computing Project (ECP) User Facilities Center for Integrated Nanotechnologies (CINT) Los Alamos Neutron

  3. Liberal Education, Human Development, and Social Vision.

    ERIC Educational Resources Information Center

    Gregory, Marshall W.

    1982-01-01

    Examines the effects of the post-Sputnik knowledge explosion. Critizes universities for teaching facts and information without values and applications and faults apathetic students who narrowly focus on job openings, pay scales, and retirement plans. Urges colleges to develop intellectual autonomy and the powers of imagination, sensitivity, and…

  4. DARPA challenge: developing new technologies for brain and spinal injuries

    NASA Astrophysics Data System (ADS)

    Macedonia, Christian; Zamisch, Monica; Judy, Jack; Ling, Geoffrey

    2012-06-01

    The repair of traumatic injuries to the central nervous system remains among the most challenging and exciting frontiers in medicine. In both traumatic brain injury and spinal cord injuries, the ultimate goals are to minimize damage and foster recovery. Numerous DARPA initiatives are in progress to meet these goals. The PREventing Violent Explosive Neurologic Trauma program focuses on the characterization of non-penetrating brain injuries resulting from explosive blast, devising predictive models and test platforms, and creating strategies for mitigation and treatment. To this end, animal models of blast induced brain injury are being established, including swine and non-human primates. Assessment of brain injury in blast injured humans will provide invaluable information on brain injury associated motor and cognitive dysfunctions. The Blast Gauge effort provided a device to measure warfighter's blast exposures which will contribute to diagnosing the level of brain injury. The program Cavitation as a Damage Mechanism for Traumatic Brain Injury from Explosive Blast developed mathematical models that predict stresses, strains, and cavitation induced from blast exposures, and is devising mitigation technologies to eliminate injuries resulting from cavitation. The Revolutionizing Prosthetics program is developing an avant-garde prosthetic arm that responds to direct neural control and provides sensory feedback through electrical stimulation. The Reliable Neural-Interface Technology effort will devise technologies to optimally extract information from the nervous system to control next generation prosthetic devices with high fidelity. The emerging knowledge and technologies arising from these DARPA programs will significantly improve the treatment of brain and spinal cord injured patients.

  5. Towards an Employment-Oriented Training Policy: An Agenda for Action. Discussion Paper No. 60.

    ERIC Educational Resources Information Center

    Kanawaty, George; Castro, Claudio de Moura

    Training systems are facing three basic considerations: (1) adjustment to demographic trends such as the population explosion in developing countries, the aging of the work force in developed countries, and the increased participation of women in economic activities; (2) changing patterns of demand, such as lower rates of growth, restructuring of…

  6. "Limited Access" Programs: Exceptions that Threaten the Florida Higher Education Articulation Agreement.

    ERIC Educational Resources Information Center

    Williams, Elizabeth Grace

    Florida's Higher Education Articulation Agreement, established in 1959, has long been recognized as a model of a state-coordinated, integrated system of public higher education. But explosive population growth combined with three years of state budget crises, resulting in $155 million of cuts to higher education, have threatened this system of 28…

  7. Challenges and Prospects of Staff Development Programmes in Nigeria's Secondary School System: An Overview

    ERIC Educational Resources Information Center

    Asaya, Samuel Adetunji

    2011-01-01

    The vices rampant now among students in Nigeria secondary schools, such as acts of indiscipline, stealing, cheating, truancy, rioting, cultism, and raping, together with population explosion, call for special skills on the part of the school administrators to be able to cope with these challenges. Consequently, this paper examines the uniqueness…

  8. Fingerprints of nucleosynthesis in the local spiral arm

    NASA Technical Reports Server (NTRS)

    Knoedlseder, J.; Bennett, K.; Bloemen, H.; Diehl, R.; Hermsen, W.; Oberlack, U.; Ryan, J.; Schoenfelder, V.; vonBallmoos, P.

    1997-01-01

    The local spiral arm with its inherent massive star population is a natural site of recent nucleosynthesis activity. The features found in 1.8 MeV observation of candidate Al-26 sources situated in this structure are discussed. The emphasis is on Loop 1, a nearby superbubble which is possibly the site of a recent supernova explosion.

  9. ESR dosimetry study of population in the vicinity of the Semipalatinsk Nuclear Test Site

    PubMed Central

    Zhumadilov, Kassym; Ivannikov, Alexander; Stepanenko, Valeriy; Zharlyganova, Dinara; Toyoda, Shin; Zhumadilov, Zhaxybay; Hoshi, Masaharu

    2013-01-01

    A tooth enamel electron spin resonance (ESR) dosimetry study was carried out with the purpose of obtaining the individual absorbed radiation doses of population from settlements in the Semipalatinsk region of Kazakhstan, which was exposed to radioactive fallout traces from nuclear explosions in the Semipalatinsk Nuclear Test Site and Lop Nor test base, China. Most of the settlements are located near the central axis of radioactive fallout trace from the most contaminating surface nuclear test, which was conducted on 29 August 1949, with the maximum detected excess dose being 430 ± 93 mGy. A maximum dose of 268 ± 79 mGy was determined from the settlements located close to radioactive fallout trace resulting from surface nuclear tests on 24 August 1956 (Ust-Kamenogorsk, Znamenka, Shemonaikha, Glubokoe, Tavriya and Gagarino). An accidental dose of 56 ± 42 mGy was found in Kurchatov city residents located close to fallout trace after the nuclear test on 7 August 1962. This method was applied to human tooth enamel to obtain individual absorbed doses of residents of the Makanchi, Urdzhar and Taskesken settlements located near the Kazakhstan–Chinese border due to the influence of nuclear tests (1964–1981) at Lop Nor. The highest dose was 123 ± 32 mGy. PMID:23404205

  10. ESR dosimetry study of population in the vicinity of the Semipalatinsk Nuclear Test Site.

    PubMed

    Zhumadilov, Kassym; Ivannikov, Alexander; Stepanenko, Valeriy; Zharlyganova, Dinara; Toyoda, Shin; Zhumadilov, Zhaxybay; Hoshi, Masaharu

    2013-07-01

    A tooth enamel electron spin resonance (ESR) dosimetry study was carried out with the purpose of obtaining the individual absorbed radiation doses of population from settlements in the Semipalatinsk region of Kazakhstan, which was exposed to radioactive fallout traces from nuclear explosions in the Semipalatinsk Nuclear Test Site and Lop Nor test base, China. Most of the settlements are located near the central axis of radioactive fallout trace from the most contaminating surface nuclear test, which was conducted on 29 August 1949, with the maximum detected excess dose being 430 ± 93 mGy. A maximum dose of 268 ± 79 mGy was determined from the settlements located close to radioactive fallout trace resulting from surface nuclear tests on 24 August 1956 (Ust-Kamenogorsk, Znamenka, Shemonaikha, Glubokoe, Tavriya and Gagarino). An accidental dose of 56 ± 42 mGy was found in Kurchatov city residents located close to fallout trace after the nuclear test on 7 August 1962. This method was applied to human tooth enamel to obtain individual absorbed doses of residents of the Makanchi, Urdzhar and Taskesken settlements located near the Kazakhstan-Chinese border due to the influence of nuclear tests (1964-1981) at Lop Nor. The highest dose was 123 ± 32 mGy.

  11. 40 CFR 267.31 - What are the general design and operation standards?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... possibility of a fire, explosion, or any unplanned sudden or non-sudden release of hazardous waste or hazardous waste constituents to air, soil, or surface water that could threaten human health or the... (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE FACILITIES...

  12. 40 CFR 264.51 - Purpose and implementation of contingency plan.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND... plan must be designed to minimize hazards to human health or the environment from fires, explosions, or any unplanned sudden or non-sudden release of hazardous waste or hazardous waste constituents to air...

  13. 40 CFR 265.51 - Purpose and implementation of contingency plan.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT... contingency plan must be designed to minimize hazards to human health or the environment from fires, explosions, or any unplanned sudden or non-sudden release of hazardous waste or hazardous waste constituents...

  14. 40 CFR 265.51 - Purpose and implementation of contingency plan.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT... contingency plan must be designed to minimize hazards to human health or the environment from fires, explosions, or any unplanned sudden or non-sudden release of hazardous waste or hazardous waste constituents...

  15. 40 CFR 265.51 - Purpose and implementation of contingency plan.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT... contingency plan must be designed to minimize hazards to human health or the environment from fires, explosions, or any unplanned sudden or non-sudden release of hazardous waste or hazardous waste constituents...

  16. 40 CFR 267.31 - What are the general design and operation standards?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... possibility of a fire, explosion, or any unplanned sudden or non-sudden release of hazardous waste or hazardous waste constituents to air, soil, or surface water that could threaten human health or the... (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE FACILITIES...

  17. 40 CFR 264.51 - Purpose and implementation of contingency plan.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND... plan must be designed to minimize hazards to human health or the environment from fires, explosions, or any unplanned sudden or non-sudden release of hazardous waste or hazardous waste constituents to air...

  18. 40 CFR 267.31 - What are the general design and operation standards?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... possibility of a fire, explosion, or any unplanned sudden or non-sudden release of hazardous waste or hazardous waste constituents to air, soil, or surface water that could threaten human health or the... (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE FACILITIES...

  19. 40 CFR 267.31 - What are the general design and operation standards?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... possibility of a fire, explosion, or any unplanned sudden or non-sudden release of hazardous waste or hazardous waste constituents to air, soil, or surface water that could threaten human health or the... (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE FACILITIES...

  20. 40 CFR 264.51 - Purpose and implementation of contingency plan.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND... plan must be designed to minimize hazards to human health or the environment from fires, explosions, or any unplanned sudden or non-sudden release of hazardous waste or hazardous waste constituents to air...

  1. A Pedagogical Experiment in Crowdsourcing and Enumerative Bibliography

    ERIC Educational Resources Information Center

    Pionke, A. D.

    2013-01-01

    Faced with increasing marginalization within English studies by the explosion of literary criticism in the 1970s, professional bibliographers began to defend their subdiscipline on pedagogical grounds. More recently, the digital revolution in the academic humanities has prompted a further revaluation of methods and outcomes in training graduate…

  2. 40 CFR 264.51 - Purpose and implementation of contingency plan.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Purpose and implementation of contingency plan. 264.51 Section 264.51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... plan must be designed to minimize hazards to human health or the environment from fires, explosions, or...

  3. 40 CFR 265.56 - Emergency procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... FACILITIES Contingency Plan and Emergency Procedures § 265.56 Emergency procedures. (a) Whenever there is an... with designated response roles if their help is needed. (b) Whenever there is a release, fire, or... possible hazards to human health or the environment that may result from the release, fire, or explosion...

  4. 40 CFR 265.56 - Emergency procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... FACILITIES Contingency Plan and Emergency Procedures § 265.56 Emergency procedures. (a) Whenever there is an... with designated response roles if their help is needed. (b) Whenever there is a release, fire, or... possible hazards to human health or the environment that may result from the release, fire, or explosion...

  5. 40 CFR 265.56 - Emergency procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... FACILITIES Contingency Plan and Emergency Procedures § 265.56 Emergency procedures. (a) Whenever there is an... with designated response roles if their help is needed. (b) Whenever there is a release, fire, or... possible hazards to human health or the environment that may result from the release, fire, or explosion...

  6. 40 CFR 265.56 - Emergency procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... FACILITIES Contingency Plan and Emergency Procedures § 265.56 Emergency procedures. (a) Whenever there is an... with designated response roles if their help is needed. (b) Whenever there is a release, fire, or... possible hazards to human health or the environment that may result from the release, fire, or explosion...

  7. A model for evaluation of satellite population management alternatives

    NASA Astrophysics Data System (ADS)

    Penny, R. E., Jr.; Jones, R. K.

    1983-12-01

    A Q-GERT model was developed to simulate the satellite environment, including the untracked man-made population, and to calculate a probability of collision for any satellite of interest. Provision for launches, explosions, collisions (including ASAT), retrieval, reposition, and decay was made. The model is structured to easily vary the rates at which these activities occur and to observe changes in the satellite population through which a satellite of interest must travel. Variance of the rates, and the resultant change in probability of collision allows evaluation of satellite population management alternatives such as reducing launch rates or increasing retrieval of spent, but still capable of exploding, satellites. The model is proposed for use by both the USAF SPACE COMMAND and NASA.

  8. Explosive Detection in Aviation Applications Using CT

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Martz, H E; Crawford, C R

    2011-02-15

    CT scanners are deployed world-wide to detect explosives in checked and carry-on baggage. Though very similar to single- and dual-energy multi-slice CT scanners used today in medical imaging, some recently developed explosives detection scanners employ multiple sources and detector arrays to eliminate mechanical rotation of a gantry, photon counting detectors for spectral imaging, and limited number of views to reduce cost. For each bag scanned, the resulting reconstructed images are first processed by automated threat recognition algorithms to screen for explosives and other threats. Human operators review the images only when these automated algorithms report the presence of possible threats.more » The US Department of Homeland Security (DHS) has requirements for future scanners that include dealing with a larger number of threats, higher probability of detection, lower false alarm rates and lower operating costs. One tactic that DHS is pursuing to achieve these requirements is to augment the capabilities of the established security vendors with third-party algorithm developers. A third-party in this context refers to academics and companies other than the established vendors. DHS is particularly interested in exploring the model that has been used very successfully by the medical imaging industry, in which university researchers develop algorithms that are eventually deployed in commercial medical imaging equipment. The purpose of this paper is to discuss opportunities for third-parties to develop advanced reconstruction and threat detection algorithms.« less

  9. Identifying hazards associated with lava deltas

    USGS Publications Warehouse

    Poland, Michael P.; Orr, Tim R.

    2014-01-01

    Lava deltas, formed where lava enters the ocean and builds a shelf of new land extending from the coastline, represent a significant local hazard, especially on populated ocean island volcanoes. Such structures are unstable and prone to collapse—events that are often accompanied by small explosions that can deposit boulders and cobbles hundreds of meters inland. Explosions that coincide with collapses of the East Lae ‘Apuki lava delta at Kīlauea Volcano, Hawai‘i, during 2005–2007 followed an evolutionary progression mirroring that of the delta itself. A collapse that occurred when the lava–ocean entry was active was associated with a blast of lithic blocks and dispersal of spatter and fine, glassy tephra. Shortly after delta growth ceased, a collapse exposed hot rock to cold ocean water, resulting in an explosion composed entirely of lithic blocks and lapilli. Further collapse of the delta after several months of inactivity, by which time it had cooled significantly, resulted in no recognizable explosion deposit. Seaward displacement and subsidence of the coastline immediately inland of the delta was measured by both satellite and ground-based sensors and occurred at rates of several centimeters per month even after the lava–ocean entry had ceased. The anomalous deformation ended only after complete collapse of the delta. Monitoring of ground deformation may therefore provide an indication of the potential for delta collapse, while the hazard associated with collapse can be inferred from the level of activity, or the time since the last activity, on the delta.

  10. Violent Mergers

    NASA Astrophysics Data System (ADS)

    Pakmor, Rüdiger

    The progenitor systems and explosion scenarios of Type Ia supernovae (SNe Ia) are still heavily debated. The violent merger scenario is a recent addition to explosion scenarios for SNe Ia. Here, two white dwarfs (WDs) in a binary system approach each other owing to the emission of gravitational waves. The interaction between the two WDs preluding or during the merger creates a hotspot on the surface of the primary, more massive, WD that ignites a detonation. If the detonation is a carbon detonation, it completely burns the primary WD leading to a SN Ia. If instead the detonation is a helium detonation in the helium shell of a carbon-oxygen WD, it burns around the primary WD in its helium shell and sends a shock wave into its core that ignites a carbon detonation. Again the primary WD is fully burned. Synthetic observables for explosion models of SNe Ia in the violent merger scenario show good agreement with normal SNe Ia and the subclass of faint, slowly evolving 02es-like SNe Ia for different masses of the primary WD. The violent merger scenario can also explain the delay time distribution and brightness distribution of normal SNe Ia. This chapter discusses in detail the mechanism that leads to ignition in the violent merger scenario, summarizes the properties of explosions in the violent merger scenario and compares to observations. It ends with a summary of the main properties of the population of normal SNe Ia and discusses to which degree they can be explained in the violent merger scenario.

  11. THE BIGGEST EXPLOSIONS IN THE UNIVERSE. II

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Whalen, Daniel J.; Smidt, Joseph; Johnson, Jarrett L.

    2013-11-10

    One of the leading contenders for the origin of supermassive black holes (SMBHs) at z ∼> 7 is catastrophic baryon collapse in atomically cooled halos at z ∼ 15. In this scenario, a few protogalaxies form in the presence of strong Lyman-Werner UV backgrounds that quench H{sub 2} formation in their constituent halos, preventing them from forming stars or blowing heavy elements into the intergalactic medium prior to formation. At masses of 10{sup 8} M{sub ☉} and virial temperatures of 10{sup 4} K, gas in these halos rapidly cools by H lines, in some cases forming 10{sup 4}-10{sup 6} M{submore » ☉} Population III stars and, a short time later, the seeds of SMBHs. Instead of collapsing directly to black holes (BHs), some of these stars died in the most energetic thermonuclear explosions in the universe. We have modeled the explosions of such stars in the dense cores of line-cooled protogalaxies in the presence of cosmological flows. In stark contrast to the explosions in diffuse regions in previous simulations, these supernovae briefly engulf the protogalaxy, but then collapse back into its dark matter potential. Fallback drives turbulence that efficiently distributes metals throughout the interior of the halo and fuels the rapid growth of nascent BHs at its center. The accompanying starburst and X-ray emission from these line-cooled galaxies easily distinguish them from more slowly evolving neighbors and might reveal the birthplaces of SMBHs on the sky.« less

  12. Lower limb explosive strength capacity in elderly women: effects of resistance training and healthy diet.

    PubMed

    Edholm, Peter; Strandberg, Emelie; Kadi, Fawzi

    2017-07-01

    The effects of 24 wk of resistance training combined with a healthy diet on lower limb explosive strength capacity were investigated in a population of healthy elderly women. Participants ( n = 63; 67.5 ± 0.4 yr) were randomized into three groups; resistance training (RT), resistance training and healthy diet (RT-HD), and control (CON). Progressive resistance training was performed at a load of 75-85% one-repetition maximum. A major adjustment in the healthy dietary approach was an n-6/n-3 polyunsaturated fatty acid (PUFA) ratio below 2. Lower limb maximal strength, explosive force capacity during dynamic and isometric movements, whole body lean mass, and physical function were assessed. Whole body lean mass significantly increased by 1.5 ± 0.5% in RT-HD only. Isometric strength performance during knee extension as well as the performance in the five sit-to-stand and single-leg-stance tests increased similarly in RT and RT-HD. Improvements in dynamic peak power and time to reach peak power (i.e shorter time) during knee extension occurred in both RT (+15.7 ± 2.6 and -11.0 ± 3.8%, respectively) and RT-HD (+24.6 ± 2.6 and -20.3 ± 2.7%, respectively); however, changes were significantly larger in RT-HD. Similarly, changes in peak force and rate of force development during squat jump were higher in RT-HD (+58.5 ± 8.4 and +185.4 ± 32.9%, respectively) compared with RT (+35.7 ± 6.9 and +105.4 ± 22.4%, respectively). In conclusion, a healthy diet rich in n-3 PUFA can optimize the effects of resistance training on dynamic explosive strength capacity during isolated lower limb movements and multijoint exercises in healthy elderly women. NEW & NOTEWORTHY Age-related decline in lower limb explosive strength leads to impaired ability to perform daily living tasks. The present randomized controlled trial demonstrates that a healthy diet rich in n-3 polyunsaturated fatty acid (n-3 PUFA) enhances resistance training-induced gains in dynamic explosive strength capacity during isolated lower limb movements and multijoint exercises in healthy elderly women. This supports the use of strategies combining resistance training and dietary changes to mitigate the decline in explosive strength capacity in older adults. Copyright © 2017 the American Physiological Society.

  13. Particle transport in subaqueous eruptions: An experimental investigation

    NASA Astrophysics Data System (ADS)

    Verolino, A.; White, J. D. L.; Zimanowski, B.

    2018-01-01

    Subaqueous volcanic eruptions are natural events common under the world's oceans. Here we report results from bench-scale underwater explosions that entrain and eject particles into a water tank. Our aim was to examine how particles are transferred to the water column and begin to sediment from it, and to visualize and interpret evolution of the 'eruption' cloud. Understanding particle transfer to water is a key requirement for using deposit characteristics to infer behaviour and evolution of an underwater eruption. For the experiments here, we used compressed argon to force different types of particles, under known driving pressures, into water within a container, and recorded the results at 1 MPx/frame and 1000 fps. Three types of runs were completed: (1) particles within water were driven into a water-filled container; (2) dry particles were driven into water; (3) dry particles were driven into air at atmospheric pressure. Across the range of particles used for all subaqueous runs, we observed: a) initial doming, b) a main expansion of decompressing gas, and c) a phase of necking, when a forced plume separated from the driving jet. Phase c did not take place for the subaerial runs. A key observation is that none of the subaqueous explosions produced a single, simple, open cavity; in all cases, multiphase mixtures of gas bubbles, particles and water were formed. Explosions in which the expanding argon ejects particles in air, analogous to delivery of particles created in an explosion, produce jets and forced plumes that release particles into the tank more readily than do those in which particles in water are driven into the tank. The latter runs mimic propulsion of an existing vent slurry by an explosion. Explosions with different particle types also yielded differences in behaviour controlled primarily by particle mass, particle density, and particle-population homogeneity. Particles were quickly delivered into the water column during plume rise following necking, with minor transfer along initial-jet margins, and for breaching explosions additional delivery from splashdown of tephra jets. Plume rise after necking also draws upward and re-entrains some groups of particles. Most delivered particles participate in initiating vertical sediment-gravity flows, some of which reached the tank floor and began lateral flow within the short duration of our experiments. Particles transferred from plume margins locally were sufficiently well-separated to settle independently from suspension.

  14. 27 CFR 555.182 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... testing of new or modified explosive materials; (2) Training in explosives detection or development or testing of explosives detection equipment; or (3) Forensic science purposes; or (b) Was plastic explosive... EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Marking of Plastic Explosives § 555.182...

  15. 27 CFR 555.182 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... testing of new or modified explosive materials; (2) Training in explosives detection or development or testing of explosives detection equipment; or (3) Forensic science purposes; or (b) Was plastic explosive... EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Marking of Plastic Explosives § 555.182...

  16. Impact of explosive volcanic eruptions around Vesuvius: a story of resilience in Roman time

    NASA Astrophysics Data System (ADS)

    Scarpati, Claudio; Perrotta, Annamaria; De Simone, Girolamo Ferdinando

    2016-03-01

    Large explosive eruptions have reshaped the landscape around Vesuvius many times in prehistoric and historical times. Previous stratigraphic surveys suggested that people living in this area have probably abandoned their settlements (in the Bronze Age) or towns and villas (in the Roman period) for centuries after each major plinian eruption. New archaeological excavations on the northern slope of Vesuvius suggest a much more intriguing scenario. At Pollena Trocchia, an ongoing excavation has shown the superimposition of three different Roman structures, sandwiched between the deposits of the AD 79, AD 472, and AD 512 Vesuvius eruptions. Each of these eruptions more or less completely destroyed and buried the buildings under meters of volcanic products. Surprisingly, after a few years or decades, a new settlement was established exactly on the top of the buried one, indicating the immediate recovery of part of the devastated area. Our research documents the destruction of Roman buildings by volcanic eruptions over a period of five centuries (first to sixth century AD) and provides new insight into human behavior after major explosive eruptions.

  17. The very young resolved stellar populations around stripped-envelope supernovae

    NASA Astrophysics Data System (ADS)

    Maund, Justyn R.

    2018-05-01

    The massive star origins for Type IIP supernovae (SNe) have been established through direct detection of their red supergiants progenitors in pre-explosion observations; however, there has been limited success in the detection of the progenitors of H-deficient SNe. The final fate of more massive stars, capable of undergoing a Wolf-Rayet phase, and the origins of Type Ibc SNe remain debated, including the relative importance of single massive star progenitors or lower mass stars stripped in binaries. We present an analysis of the ages and spatial distributions of massive stars around the sites of 23 stripped-envelope SNe, as observed with the Hubble Space Telescope, to probe the possible origins of the progenitors of these events. Using a Bayesian stellar populations analysis scheme, we find characteristic ages for the populations observed within 150 pc of the target Type IIb, Ib, and Ic SNe to be log (t) = 7.20, 7.05, and 6.57, respectively. The Type Ic SNe in the sample are nearly all observed within 100 pc of young, dense stellar populations. The environment around SN 2002ap is an important exception both in terms of age and spatial properties. These findings may support the hypothesis that stars with Minit > 30 M⊙ produce a relatively large proportion of Type Ibc SNe, and that these SN subtypes arise from progressively more massive progenitors. Significantly higher extinctions are derived towards the populations hosting these SNe than previously used in analysis of constraints from pre-explosion observations. The large initial masses inferred for the progenitors are in stark contrast with the low ejecta masses estimated from SN light curves.

  18. Long-term prospects: Mitigation of supernova and gamma-ray burst threat to intelligent beings

    NASA Astrophysics Data System (ADS)

    Ćirković, Milan M.; Vukotić, Branislav

    2016-12-01

    We consider global catastrophic risks due to cosmic explosions (supernovae, magnetars and gamma-ray bursts) and possible mitigation strategies by humans and other hypothetical intelligent beings. While by their very nature these events are so huge to daunt conventional thinking on mitigation and response, we wish to argue that advanced technological civilizations would be able to develop efficient responses in the domain of astroengineering within their home planetary systems. In particular, we suggest that construction of shielding swarms of small objects/particles confined by electromagnetic fields could be one way of mitigating the risk of cosmic explosions and corresponding ionizing radiation surges. Such feats of astroengineering could, in principle, be detectable from afar by advanced Dysonian SETI searches.

  19. Airway symptoms and lung function in the local population after the oil tank explosion in Gulen, Norway.

    PubMed

    Granslo, Jens-Tore; Bråtveit, Magne; Hollund, Bjørg Eli; Irgens, Ågot; Svanes, Cecilie; Magerøy, Nils; Moen, Bente Elisabeth

    2012-12-12

    Oil tanks containing a mixture of hydrocarbons, including sulphuric compounds, exploded and caught fire in an industrial harbour. This study assesses airway symptoms and lung function in the nearby population 1½ years after the explosion. A cross-sectional study included individuals ≥18 years old. Individuals living <6 km (sub-groups <3km and 3-6 km) from the accident site formed the exposed group, individuals living >20 km away formed a control group. A questionnaire and spirometry tests were completed by 223 exposed individuals (response rate men 70%, women 75%) and 179 control individuals (response rate men 51%, women 65%). Regression analyses included adjustment for smoking, occupational exposure, atopy, infection in the preceding month and age. Analyses of symptoms were also adjusted for stress reactions related to the accident. Exposed individuals experienced significantly more blocked nose (odds ratio 1.7 [95% confidence interval 1.0, 2.8]), rhinorrhoea (1.6 [1.1, 3.3]), nose irritation (3.4 [2.0, 5.9]), sore throat (3.1 [1.8, 5.5]), morning cough (3.5 [2.0, 5.5]), daily cough (2.2 [1.4, 3.7]), cough >3 months a year (2.9 [1.5, 5.3]) and cough with phlegm (1.9 [1.2, 3.1]) than control individuals. A significantly increasing trend was found for nose symptoms and cough, depending on the proximity of home address to explosion site (daily cough, 3-6km 1.8 [1.0, 3.1], <3km 3.0 [1.7, 6.4]). Lung function measurements were significantly lower in the exposed group than in the control group, FEV1 adjusted mean difference -123 mL [95% confidence interval -232, -14]), FEV1% predicted -2.5 [-5.5, 0.5], FVC -173 mL [- 297, -50], FVC% predicted -3.1 [- 5.9, -0.4], and airway obstruction (GOLD II/III). Based on cross sectional analyses, individuals living in an area with air pollution from an oil tank explosion had more airway symptoms and lower lung function than a control group 1½ years after the incident.

  20. Conformers of CL-20 explosive and ab initio refinement using perturbation theory: implications to detonation mechanisms.

    PubMed

    Molt, Robert W; Bartlett, Rodney J; Watson, Thomas; Bazanté, Alexandre P

    2012-12-13

    We have identified the major conformers of CL-20 explosive, otherwise known as 2,4,6,8,10,12-hexanitrohexaazaisowurtzitane, more formally known as 2,4,6,8,10,12-hexanitrohexaazatetracyclo[5.5.0.0]-dodecane, via Monte Carlo search in conformational space through molecular mechanics and subsequent quantum mechanical refinement using perturbation theory. Our search produced enough conformers to account for all of the various forms of CL-20 found in crystals. This suggests that our methodology will be useful in studying the conformational landscape of other nitramines. The energy levels of the conformers found are all within 0.25 eV of one another based on MBPT(2)/6-311G(d,p); consequently, without further refinement from a method such as coupled cluster theory, all conformers may reasonably be populated at STP in the gas phase. We also report the harmonic vibrational frequencies of conformers, including the implications on the mechanism of detonation. In particular, we establish that the weakest N-N nitramine of CL-20 is the cyclohexane equatorial nitramine. This preliminary mapping of the conformers of CL-20 makes it possible to study the mechanism of detonation of this explosive rigorously in future work.

  1. Disease-induced resource constraints can trigger explosive epidemics

    NASA Astrophysics Data System (ADS)

    Böttcher, L.; Woolley-Meza, O.; Araújo, N. A. M.; Herrmann, H. J.; Helbing, D.

    2015-11-01

    Advances in mathematical epidemiology have led to a better understanding of the risks posed by epidemic spreading and informed strategies to contain disease spread. However, a challenge that has been overlooked is that, as a disease becomes more prevalent, it can limit the availability of the capital needed to effectively treat those who have fallen ill. Here we use a simple mathematical model to gain insight into the dynamics of an epidemic when the recovery of sick individuals depends on the availability of healing resources that are generated by the healthy population. We find that epidemics spiral out of control into “explosive” spread if the cost of recovery is above a critical cost. This can occur even when the disease would die out without the resource constraint. The onset of explosive epidemics is very sudden, exhibiting a discontinuous transition under very general assumptions. We find analytical expressions for the critical cost and the size of the explosive jump in infection levels in terms of the parameters that characterize the spreading process. Our model and results apply beyond epidemics to contagion dynamics that self-induce constraints on recovery, thereby amplifying the spreading process.

  2. GPS Signal Feature Analysis to Detect Volcanic Plume on Mount Etna

    NASA Astrophysics Data System (ADS)

    Cannavo', Flavio; Aranzulla, Massimo; Scollo, Simona; Puglisi, Giuseppe; Imme', Giuseppina

    2014-05-01

    Volcanic ash produced during explosive eruptions can cause disruptions to aviation operations and to population living around active volcanoes. Thus, detection of volcanic plume becomes a crucial issue to reduce troubles connected to its presence. Nowadays, the volcanic plume detection is carried out by using different approaches such as satellites, radars and lidars. Recently, the capability of GPS to retrieve volcanic plumes has been also investigated and some tests applied to explosive activity of Etna have demonstrated that also the GPS may give useful information. In this work, we use the permanent and continuous GPS network of the Istituto Nazionale di Geofisica e Vulcanologia, Osservatorio Etneo (Italy) that consists of 35 stations located all around volcano flanks. Data are processed by the GAMIT package developed by Massachusetts Institute of Technology. Here we investigate the possibility to quantify the volcanic plume through the GPS signal features and to estimate its spatial distribution by means of a tomographic inversion algorithm. The method is tested on volcanic plumes produced during the lava fountain of 4-5 September 2007, already used to confirm if weak explosive activity may or may not affect the GPS signals.

  3. Disease-induced resource constraints can trigger explosive epidemics

    PubMed Central

    Böttcher, L.; Woolley-Meza, O.; Araújo, N. A. M.; Herrmann, H. J.; Helbing, D.

    2015-01-01

    Advances in mathematical epidemiology have led to a better understanding of the risks posed by epidemic spreading and informed strategies to contain disease spread. However, a challenge that has been overlooked is that, as a disease becomes more prevalent, it can limit the availability of the capital needed to effectively treat those who have fallen ill. Here we use a simple mathematical model to gain insight into the dynamics of an epidemic when the recovery of sick individuals depends on the availability of healing resources that are generated by the healthy population. We find that epidemics spiral out of control into “explosive” spread if the cost of recovery is above a critical cost. This can occur even when the disease would die out without the resource constraint. The onset of explosive epidemics is very sudden, exhibiting a discontinuous transition under very general assumptions. We find analytical expressions for the critical cost and the size of the explosive jump in infection levels in terms of the parameters that characterize the spreading process. Our model and results apply beyond epidemics to contagion dynamics that self-induce constraints on recovery, thereby amplifying the spreading process. PMID:26568377

  4. [The tragic doubt].

    PubMed

    Musial, G

    2001-01-01

    Starting with two statements made by two great artists and witnesses of the XXth century - Joseph Brodsky and the Polish poet, Tadeusz Rozewicz - the author discusses the roots of our current moral crisis to which we ourselves bear witness: in the unchecked population explosion (Brodsky), and in the sinister legacy of World War II, the effects of which we witness on a daily basis (Rozewicz). The author recalls a third witness: Czeslaw Milosz, who wrote that the world's progress exhibits an inevitable tendency toward nihilism. In his discourse with the three statements mentioned, the author refers to certain XXth century intellectuals - Ortega y Gasset, Cardinal Joseph Ratzinger, Mircea Eliade, Herbert Read - who confirm and develop the thesis of man s spiritual fall and rejection of transcendence through technology. The author further illustrates his thesis with examples taken from the scientific research concerning IT, cloning, euthanasia, as well as from the world of the arts from the apocalyptic works of Hieronymous Bosch and Pieter Bruegel the Elder to the latest performers. He invokes a worldview which, by rejecting the metaphysics of man s birth, aging, and death, also rejects the judeo-christian taboo of the human body as a "dwelling place for the spirit" (porno festivals, exhibitions of human corpses by Prof. von Hagens in Germany).

  5. Biostimulation and microbial community profiling reveal insights on RDX transformation in groundwater

    DOE PAGES

    Wang, Dongping; Boukhalfa, Hakim; Marina, Oana; ...

    2016-11-17

    Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) is a high explosive released to the environment as a result of weapons manufacturing and testing worldwide. At Los Alamos National Laboratory, the Technical Area (TA) 16 260 Outfall discharged high-explosives-bearing water from a high-explosives-machining facility to Cañon de Valle during 1951 through 1996. These discharges served as a primary source of high-explosives and inorganic-element contamination in the area. Data indicate that springs, surface water, alluvial groundwater, and perched-intermediate groundwater contain explosive compounds, including RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine); HMX (octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine); and TNT (2,4,6-trinitrotoluene). RDX has been detected in the regional aquifer in several wells, and a corrective measures evaluation ismore » planned to identify remedial alternatives to protect the regional aquifer. Perched-intermediate groundwater at Technical Area 16 is present at depths from 650 ft to 1200 ft bgs. In this study, we examined the microbial diversity in a monitoring well completed in perched-intermediate groundwater contaminated by RDX, and examined the response of the microbial population to biostimulation under varying geochemical conditions. Results show that the groundwater microbiome was dominated by Actinobacteria and Proteobacteria. A total of 1,605 operational taxonomic units (OTUs) in 96 bacterial genera were identified. Rhodococcus was the most abundant genus (30.6%) and a total of 46 OTUs were annotated as Rhodococcus. One OTU comprising 25.2% of total sequences was closely related to a RDX -degrading strain R. erythropolis HS4. A less abundant OTU from the Pseudomonas family closely related to RDX-degrading strain P. putida II-B was also present. Biostimulation significantly enriched Proteobacteria but decreased/eliminated the population of Actinobacteria. Consistent with RDX degradation, the OTU closely related to the RDX-degrading P. putida strain II-B was specifically enriched in the RDX-degrading samples. Analysis of the accumulation of RDX-degradation products reveals that during active RDX degradation, there is a transient increase in the concentration of the degradation products MNX, DNX, TNX, and NDAB. The accumulation of these degradation products suggests that RDX is degraded via sequential reduction of the nitro functional groups followed by abiotic ring-cleavage. Here, the results suggest that strict anaerobic conditions are needed to stimulate RDX degradation under the TA-16 site-specific conditions.« less

  6. Biostimulation and microbial community profiling reveal insights on RDX transformation in groundwater

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang, Dongping; Boukhalfa, Hakim; Marina, Oana

    Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) is a high explosive released to the environment as a result of weapons manufacturing and testing worldwide. At Los Alamos National Laboratory, the Technical Area (TA) 16 260 Outfall discharged high-explosives-bearing water from a high-explosives-machining facility to Cañon de Valle during 1951 through 1996. These discharges served as a primary source of high-explosives and inorganic-element contamination in the area. Data indicate that springs, surface water, alluvial groundwater, and perched-intermediate groundwater contain explosive compounds, including RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine); HMX (octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine); and TNT (2,4,6-trinitrotoluene). RDX has been detected in the regional aquifer in several wells, and a corrective measures evaluation ismore » planned to identify remedial alternatives to protect the regional aquifer. Perched-intermediate groundwater at Technical Area 16 is present at depths from 650 ft to 1200 ft bgs. In this study, we examined the microbial diversity in a monitoring well completed in perched-intermediate groundwater contaminated by RDX, and examined the response of the microbial population to biostimulation under varying geochemical conditions. Results show that the groundwater microbiome was dominated by Actinobacteria and Proteobacteria. A total of 1,605 operational taxonomic units (OTUs) in 96 bacterial genera were identified. Rhodococcus was the most abundant genus (30.6%) and a total of 46 OTUs were annotated as Rhodococcus. One OTU comprising 25.2% of total sequences was closely related to a RDX -degrading strain R. erythropolis HS4. A less abundant OTU from the Pseudomonas family closely related to RDX-degrading strain P. putida II-B was also present. Biostimulation significantly enriched Proteobacteria but decreased/eliminated the population of Actinobacteria. Consistent with RDX degradation, the OTU closely related to the RDX-degrading P. putida strain II-B was specifically enriched in the RDX-degrading samples. Analysis of the accumulation of RDX-degradation products reveals that during active RDX degradation, there is a transient increase in the concentration of the degradation products MNX, DNX, TNX, and NDAB. The accumulation of these degradation products suggests that RDX is degraded via sequential reduction of the nitro functional groups followed by abiotic ring-cleavage. Here, the results suggest that strict anaerobic conditions are needed to stimulate RDX degradation under the TA-16 site-specific conditions.« less

  7. Biostimulation and microbial community profiling reveal insights on RDX transformation in groundwater.

    PubMed

    Wang, Dongping; Boukhalfa, Hakim; Marina, Oana; Ware, Doug S; Goering, Tim J; Sun, Fengjie; Daligault, Hajnalka E; Lo, Chien-Chi; Vuyisich, Momchilo; Starkenburg, Shawn R

    2017-04-01

    Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) is a high explosive released to the environment as a result of weapons manufacturing and testing worldwide. At Los Alamos National Laboratory, the Technical Area (TA) 16 260 Outfall discharged high-explosives-bearing water from a high-explosives-machining facility to Cañon de Valle during 1951 through 1996. These discharges served as a primary source of high-explosives and inorganic-element contamination in the area. Data indicate that springs, surface water, alluvial groundwater, and perched-intermediate groundwater contain explosive compounds, including RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine); HMX (octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine); and TNT (2,4,6-trinitrotoluene). RDX has been detected in the regional aquifer in several wells, and a corrective measures evaluation is planned to identify remedial alternatives to protect the regional aquifer. Perched-intermediate groundwater at Technical Area 16 is present at depths from 650 ft to 1200 ft bgs. In this study, we examined the microbial diversity in a monitoring well completed in perched-intermediate groundwater contaminated by RDX, and examined the response of the microbial population to biostimulation under varying geochemical conditions. Results show that the groundwater microbiome was dominated by Actinobacteria and Proteobacteria. A total of 1,605 operational taxonomic units (OTUs) in 96 bacterial genera were identified. Rhodococcus was the most abundant genus (30.6%) and a total of 46 OTUs were annotated as Rhodococcus. One OTU comprising 25.2% of total sequences was closely related to a RDX -degrading strain R. erythropolis HS4. A less abundant OTU from the Pseudomonas family closely related to RDX-degrading strain P. putida II-B was also present. Biostimulation significantly enriched Proteobacteria but decreased/eliminated the population of Actinobacteria. Consistent with RDX degradation, the OTU closely related to the RDX-degrading P. putida strain II-B was specifically enriched in the RDX-degrading samples. Analysis of the accumulation of RDX-degradation products reveals that during active RDX degradation, there is a transient increase in the concentration of the degradation products MNX, DNX, TNX, and NDAB. The accumulation of these degradation products suggests that RDX is degraded via sequential reduction of the nitro functional groups followed by abiotic ring-cleavage. The results suggest that strict anaerobic conditions are needed to stimulate RDX degradation under the TA-16 site-specific conditions. © 2016 The Authors. MicrobiologyOpen published by John Wiley & Sons Ltd.

  8. Laser photoacoustic spectroscopy helps fight terrorism: High sensitivity detection of chemical Warfare Agent and explosives

    NASA Astrophysics Data System (ADS)

    Patel, C. K. N.

    2008-01-01

    Tunable laser photoacoustic spectroscopy is maturing rapidly in its applications to real world problems. One of the burning problems of the current turbulent times is the threat of terrorist acts against civilian population. This threat appears in two distinct forms. The first is the potential release of chemical warfare agents (CWA), such as the nerve agents, in a crowded environment. An example of this is the release of Sarin by Aum Shinrikyo sect in a crowded Tokyo subway in 1995. An example of the second terrorist threat is the ever-present possible suicide bomber in crowded environment such as airports, markets and large buildings. Minimizing the impact of both of these threats requires early detection of the presence of the CWAs and explosives. Photoacoustic spectroscopy is an exquisitely sensitive technique for the detection of trace gaseous species, a property that Pranalytica has extensively exploited in its CO2 laser based commercial instrumentation for the sub-ppb level detection of a number of industrially important gases including ammonia, ethylene, acrolein, sulfur hexafluoride, phosphine, arsine, boron trichloride and boron trifluoride. In this presentation, I will focus, however, on our recent use of broadly tunable single frequency high power room temperature quantum cascade lasers (QCL) for the detection of the CWAs and explosives. Using external grating cavity geometry, we have developed room temperature QCLs that produce continuously tunable single frequency CW power output in excess of 300 mW at wavelengths covering 5 μm to 12 μm. I will present data that show a CWA detection capability at ppb levels with false alarm rates below 1:108. I will also show the capability of detecting a variety of explosives at a ppb level, again with very low false alarm rates. Among the explosives, we have demonstrated the capability of detecting homemade explosives such as triacetone triperoxide and its liquid precursor, acetone which is a common household liquid. This capability, deployed at airports and other public places, will go a long way towards increasing public safety and minimizing inconveniences faced in airline travel.

  9. Medical geology in the framework of the sustainable development goals.

    PubMed

    Bundschuh, Jochen; Maity, Jyoti Prakash; Mushtaq, Shahbaz; Vithanage, Meththika; Seneweera, Saman; Schneider, Jerusa; Bhattacharya, Prosun; Khan, Nasreen Islam; Hamawand, Ihsan; Guilherme, Luiz R G; Reardon-Smith, Kathryn; Parvez, Faruque; Morales-Simfors, Nury; Ghaze, Sara; Pudmenzky, Christa; Kouadio, Louis; Chen, Chien-Yen

    2017-03-01

    Exposure to geogenic contaminants (GCs) such as metal(loid)s, radioactive metals and isotopes as well as transuraniums occurring naturally in geogenic sources (rocks, minerals) can negatively impact on environmental and human health. The GCs are released into the environment by natural biogeochemical processes within the near-surface environments and/or by anthropogenic activities such as mining and hydrocarbon exploitation as well as exploitation of geothermal resources. They can contaminate soil, water, air and biota and subsequently enter the food chain with often serious health impacts which are mostly underestimated and poorly recognized. Global population explosion and economic growth and the associated increase in demand for water, energy, food, and mineral resources result in accelerated release of GCs globally. The emerging science of "medical geology" assesses the complex relationships between geo-environmental factors and their impacts on humans and environments and is related to the majority of the 17 Sustainable Development Goals in the 2030 Agenda of the United Nations for Sustainable Development. In this paper, we identify multiple lines of evidence for the role of GCs in the incidence of diseases with as yet unknown etiology (causation). Integrated medical geology promises a more holistic understanding of the occurrence, mobility, bioavailability, bio-accessibility, exposure and transfer mechanisms of GCs to the food-chain and humans, and the related ecotoxicological impacts and health effects. Scientific evidence based on this approach will support adaptive solutions for prevention, preparedness and response regarding human and environmental health impacts originating from exposure to GCs. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. Exploiting the explosion of information associated with whole genome sequencing to tackle Shiga toxin-producing Escherichia coli (STEC) in global food production systems

    USDA-ARS?s Scientific Manuscript database

    The rates of foodborne disease caused by gastrointestinal pathogens continue to be a concern in both the developed and developing worlds. The growing world population, the increasing complexity of agri-food networks and the wide range of foods now associated with STEC are potential drivers for incre...

  11. Neutron-star–black-hole binaries produced by binary-driven hypernovae

    DOE PAGES

    Fryer, Chris L.; Oliveira, F. G.; Rueda, Jorge A.; ...

    2015-12-04

    Here, binary-driven hypernovae (BdHNe) within the induced gravitational collapse paradigm have been introduced to explain energetic (E iso ≳10 52 erg), long gamma-ray bursts (GRBs) associated with type Ic supernovae (SNe). The progenitor is a tight binary composed of a carbon-oxygen (CO) core and a neutron-star (NS) companion, a subclass of the newly proposed “ultrastripped” binaries. The CO-NS short-period orbit causes the NS to accrete appreciable matter from the SN ejecta when the CO core collapses, ultimately causing it to collapse to a black hole (BH) and producing a GRB. These tight binaries evolve through the SN explosion very differentlymore » than compact binaries studied in population synthesis calculations. First, the hypercritical accretion onto the NS companion alters both the mass and the momentum of the binary. Second, because the explosion time scale is on par with the orbital period, the mass ejection cannot be assumed to be instantaneous. This dramatically affects the post-SN fate of the binary. Finally, the bow shock created as the accreting NS plows through the SN ejecta transfers angular momentum, braking the orbit. These systems remain bound even if a large fraction of the binary mass is lost in the explosion (well above the canonical 50% limit), and even large kicks are unlikely to unbind the system. Indeed, BdHNe produce a new family of NS-BH binaries unaccounted for in current population synthesis analyses and, although they may be rare, the fact that nearly 100% remain bound implies that they may play an important role in the compact merger rate, important for gravitational waves that, in turn, can produce a new class of ultrashort GRBs.« less

  12. Neutron-Star-Black-Hole Binaries Produced by Binary-Driven Hypernovae.

    PubMed

    Fryer, Chris L; Oliveira, F G; Rueda, J A; Ruffini, R

    2015-12-04

    Binary-driven hypernovae (BdHNe) within the induced gravitational collapse paradigm have been introduced to explain energetic (E_{iso}≳10^{52}  erg), long gamma-ray bursts (GRBs) associated with type Ic supernovae (SNe). The progenitor is a tight binary composed of a carbon-oxygen (CO) core and a neutron-star (NS) companion, a subclass of the newly proposed "ultrastripped" binaries. The CO-NS short-period orbit causes the NS to accrete appreciable matter from the SN ejecta when the CO core collapses, ultimately causing it to collapse to a black hole (BH) and producing a GRB. These tight binaries evolve through the SN explosion very differently than compact binaries studied in population synthesis calculations. First, the hypercritical accretion onto the NS companion alters both the mass and the momentum of the binary. Second, because the explosion time scale is on par with the orbital period, the mass ejection cannot be assumed to be instantaneous. This dramatically affects the post-SN fate of the binary. Finally, the bow shock created as the accreting NS plows through the SN ejecta transfers angular momentum, braking the orbit. These systems remain bound even if a large fraction of the binary mass is lost in the explosion (well above the canonical 50% limit), and even large kicks are unlikely to unbind the system. Indeed, BdHNe produce a new family of NS-BH binaries unaccounted for in current population synthesis analyses and, although they may be rare, the fact that nearly 100% remain bound implies that they may play an important role in the compact merger rate, important for gravitational waves that, in turn, can produce a new class of ultrashort GRBs.

  13. Source discrimination between Mining blasts and Earthquakes in Tianshan orogenic belt, NW China

    NASA Astrophysics Data System (ADS)

    Tang, L.; Zhang, M.; Wen, L.

    2017-12-01

    In recent years, a large number of quarry blasts have been detonated in Tianshan Mountains of China. It is necessary to discriminate those non-earthquake records from the earthquake catalogs in order to determine the real seismicity of the region. In this study, we have investigated spectral ratios and amplitude ratios as discriminants for regional seismic-event identification using explosions and earthquakes recorded at Xinjiang Seismic Network (XJSN) of China. We used a data set that includes 1071 earthquakes and 2881 non-earthquakes as training data recorded by the XJSN between years of 2009 and 2016, with both types of events in a comparable local magnitude range (1.5 to 2.9). The non-earthquake and earthquake groups were well separated by amplitude ratios of Pg/Sg, with the separation increasing with frequency when averaged over three stations. The 8- to 15-Hz Pg/Sg ratio was proved to be the most precise and accurate discriminant, which works for more than 90% of the events. In contrast, the P spectral ratio performed considerably worse with a significant overlap (about 60% overlap) between the earthquake and explosion populations. The comparison results show amplitude ratios between compressional and shear waves discriminate better than low-frequency to high-frequency spectral ratios for individual phases. In discriminating between explosions and earthquakes, none of two discriminants were able to completely separate the two populations of events. However, a joint discrimination scheme employing simple majority voting reduces misclassifications to 10%. In the region of the study, 44% of the examined seismic events were determined to be non-earthquakes and 55% to be earthquakes. The earthquakes occurring on land are related to small faults, while the blasts are concentrated in large quarries.

  14. Presenting Numerical Modelling of Explosive Volcanic Eruption to a General Public

    NASA Astrophysics Data System (ADS)

    Demaria, C.; Todesco, M.; Neri, A.; Blasi, G.

    2001-12-01

    Numerical modeling of explosive volcanic eruptions has been widely applied, during the last decades, to study pyroclastic flows dispersion along volcano's flanks and to evaluate their impact on urban areas. Results from these transient multi-phase and multi-component simulations are often reproduced in form of computer animations, representing the spatial and temporal evolution of relevant flow variables (such as temperature, or particle concentration). Despite being a sophisticated, technical tool to analyze and share modeling results within the scientific community, these animations truly look like colorful cartoons showing an erupting volcano and are especially suited to be shown to a general public. Thanks to their particular appeal, and to the large interest usually risen by exploding volcanoes, these animations have been presented several times on television and magazines and are currently displayed in a permanent exposition, at the Vesuvius Observatory in Naples. This work represents an effort to produce an accompanying tool for these animations, capable of explaining to a large audience the scientific meaning of what can otherwise look as a graphical exercise. Dealing with research aimed at the study of dangerous, explosive volcanoes, improving the general understanding of these scientific results plays an important role as far as risk perception is concerned. An educated population has better chances to follow an appropriate behavior, i.e.: one that could lead, on the long period, to a reduction of the potential risk. In this sense, a correct divulgation of scientific results, while improving the confidence of the population in the scientific community, should belong to the strategies adopted to mitigate volcanic risk. Due to the relevance of the long term final goal of such divulgation experiment, this work represents an interdisciplinary effort, combining scientific expertise and specific competence from the modern communication science and risk perception studies.

  15. Effects of ethanol-based fuel contamination: microbial community changes, production of regulated compounds, and methane generation.

    PubMed

    Nelson, Denice K; Lapara, Timothy M; Novak, Paige J

    2010-06-15

    Ethanol-based fuels are becoming more heavily used, increasing the likelihood of ethanol-based fuel spills during transportation and storage. Although ethanol is well-known to be readily biodegradable, very little is known about the effects that such a spill might have on an indigenous microbial community. Of particular concern is that ethanol contamination could stimulate the growth of organisms that can generate regulated compounds and/or produce explosive quantities of methane gas. A column-based study was performed to elucidate the potential impacts of ethanol-based fuel (E85) on the indigenous microbial community during a simulated fuel spill. A continuous dilute supply of E85 resulted in profound shifts in both the bacterial and archaeal communities. The shift was accompanied by the production of high concentrations of volatile fatty acids and butanol, a compound that is regulated in groundwater by some states. Results also indicated that a continuous feed of dilute E85 generated explosive levels of methane within one month of column operation. Quantitative PCR data showed a statistically significant increase in methanogenic populations when compared to a control column. The elevated population numbers correlated to areas of the column receiving a sustained carbon load. Toxicity data indicated that microbial growth was completely inhibited (as evidenced by absence of ethanol breakdown products) at ethanol levels above 6% (v/v). These data suggest that ethanol from ethanol-based fuel can be readily degraded, but can also produce metabolic products that are regulated as well as explosive levels of methane. The core of an E85 spill may serve as a long-term source of contamination as it cannot be degraded until significant dilution has occurred.

  16. Neutron-Star-Black-Hole Binaries Produced by Binary-Driven Hypernovae

    NASA Astrophysics Data System (ADS)

    Fryer, Chris L.; Oliveira, F. G.; Rueda, J. A.; Ruffini, R.

    2015-12-01

    Binary-driven hypernovae (BdHNe) within the induced gravitational collapse paradigm have been introduced to explain energetic (Eiso≳1052 erg ), long gamma-ray bursts (GRBs) associated with type Ic supernovae (SNe). The progenitor is a tight binary composed of a carbon-oxygen (CO) core and a neutron-star (NS) companion, a subclass of the newly proposed "ultrastripped" binaries. The CO-NS short-period orbit causes the NS to accrete appreciable matter from the SN ejecta when the CO core collapses, ultimately causing it to collapse to a black hole (BH) and producing a GRB. These tight binaries evolve through the SN explosion very differently than compact binaries studied in population synthesis calculations. First, the hypercritical accretion onto the NS companion alters both the mass and the momentum of the binary. Second, because the explosion time scale is on par with the orbital period, the mass ejection cannot be assumed to be instantaneous. This dramatically affects the post-SN fate of the binary. Finally, the bow shock created as the accreting NS plows through the SN ejecta transfers angular momentum, braking the orbit. These systems remain bound even if a large fraction of the binary mass is lost in the explosion (well above the canonical 50% limit), and even large kicks are unlikely to unbind the system. Indeed, BdHNe produce a new family of NS-BH binaries unaccounted for in current population synthesis analyses and, although they may be rare, the fact that nearly 100% remain bound implies that they may play an important role in the compact merger rate, important for gravitational waves that, in turn, can produce a new class of ultrashort GRBs.

  17. Seismo-volcanic monitoring at Furnas Volcano (Azores): radon (222Rn) concentration in groundwater

    NASA Astrophysics Data System (ADS)

    Silva, Catarina; Virgílio Cruz, José; Ferreira, Teresa; Viveiros, Fátima; Freire, Pedro; Allard, Patrick

    2017-04-01

    The Azores archipelago, located in the middle of the North Atlantic Ocean, is composed of nine volcanic islands that formed at the triple junction of the North American, Eurasian and African (Nubian) tectonic plates. These volcanic islands were the sites of several eruptions and destructive earthquakes since human settlement in the 15th century. S. Miguel Island, the largest and most densely populated island of the Azores, hosts three active strato-volcanoes with calderas. Furnas Volcano is one of these. Its eruptive activity has been essentially explosive, involving magmas with trachytic (s.l.) composition. In the last 5000 years at least 10 explosive eruptions occurred inside the caldera of Furnas. The last one occurred in 1630 and was subplinian in character. Since then an intense hydrothermal activity has persisted, involving four main fumarolic fields, thermal springs, CO2-rich springs, several soil diffuse degassing areas (CO2 and 222Rn), as well as occasional hydrothermal explosions. In the past decade we have developed a radon survey of Furnas hydrothermal manifestations. Here we report on the radon survey of twelve water springs, located inside the caldera, and representative of the different water types encountered at the volcano (orthothermal, thermal and CO2-rich springs). Bimonthly sampling and determination of radon activity and water temperature was performed in the selected springs between years 2007 and 2011. At each sampling point two water samples were collected for radon dosing in laboratory with the RAD7 equipment. A decay correction was applied to each sample. The average radon activities were found to vary between 1.15 Bq/L and 29.77 Bq/L, while water temperatures ranged between 16.5 °C and 76.2 °C. As a whole radon activities inversely correlate with water temperature, with orthothermal springs showing higher radon activity than thermal springs. Temporal variations in both parameters appear to be mainly determined by seasonal variations of environmental conditions as soil temperature, rainfall and soil water content, rather than by volcanic activity, with the exception of one spring where radon activity seems to change more closely relate to the seismic activity of Furnas Volcano. Because some of the surveyed waters are often drunk by the local population and tourists, our results are also useful in a public health perspective. We conclude that the measured radon activities do not pose any health problem, as they remain under the safety threshold (100 Bq/L) defined by the World Health Organization. The research performed allowed to define the radon background for each one of the groundwater discharges sampled and to identify the environmental parameters that can influence the radon concentration in the groundwater of Furnas Volcano, allowing more easily to identify a future reactivation of this volcanic system.

  18. Geology of the Ugashik-Mount Peulik Volcanic Center, Alaska

    USGS Publications Warehouse

    Miller, Thomas P.

    2004-01-01

    The Ugashik-Mount Peulik volcanic center, 550 km southwest of Anchorage on the Alaska Peninsula, consists of the late Quaternary 5-km-wide Ugashik caldera and the stratovolcano Mount Peulik built on the north flank of Ugashik. The center has been the site of explosive volcanism including a caldera-forming eruption and post-caldera dome-destructive activity. Mount Peulik has been formed entirely in Holocene time and erupted in 1814 and 1845. A large lava dome occupies the summit crater, which is breached to the west. A smaller dome is perched high on the southeast flank of the cone. Pyroclastic-flow deposits form aprons below both domes. One or more sector-collapse events occurred early in the formation of Mount Peulik volcano resulting in a large area of debris-avalanche deposits on the volcano's northwest flank. The Ugashik-Mount Peulik center is a calcalkaline suite of basalt, andesite, dacite, and rhyolite, ranging in SiO2 content from 51 to 72 percent. The Ugashik-Mount Peulik magmas appear to be co-genetic in a broad sense and their compositional variation has probably resulted from a combination of fractional crystallization and magma-mixing. The most likely scenario for a future eruption is that one or more of the summit domes on Mount Peulik are destroyed as new magma rises to the surface. Debris avalanches and pyroclastic flows may then move down the west and, less likely, east flanks of the volcano for distances of 10 km or more. A new lava dome or series of domes would be expected to form either during or within some few years after the explosive disruption of the previous dome. This cycle of dome disruption, pyroclastic flow generation, and new dome formation could be repeated several times in a single eruption. The volcano poses little direct threat to human population as the area is sparsely populated. The most serious hazard is the effect of airborne volcanic ash on aircraft since Mount Peulik sits astride heavily traveled air routes connecting the U.S. and Europe to Asia. Activity of the type described could produce eruption columns to heights of 15 km and result in significant amounts of ash 250-300 km downwind.

  19. Sonoran pronghorn habitat use on landscapes disturbed by military activities

    USGS Publications Warehouse

    Krausman, P.R.; Harris, L.K.; Haas, S.K.; Koenen, Kiana K. G.; Devers, P.; Bunting, D.; Barb, M.

    2005-01-01

    The Sonoran pronghorn (Antilocapra americana sonoriensis) population in the United States declined to ???33 animals in January 2003. Low population numbers and unstable recruitment are concerns for biologists managing this subspecies. We examined habitat use by pronghorn from 1999 to 2002 on a portion of the Barry M. Goldwater Range (BMGR) used for military exercises. We overlaid locations of pronghorn (n= 1,203) on 377 1-km2 blocks within the North (NTAC) and South Tactical Ranges (STAC), BMGR; we classified vegetation associations and disturbance status (e.g., airfields, targets, roads) for each block. Locations of pronghorn were distributed in proportion to vegetation associations on NTAC and STAC. Sightings of pronghorns were biased toward disturbed blocks, with 73% of locations of pronghorn occurring in proximity to mock airfields, high-explosive hills (e.g., targets for live high-explosive bombs and rockets), other targets, and roads. Disturbed landscapes on the BMGR may attract Sonoran pronghorn by creating favorable forage. Habitat manipulations simulating the effects of military disturbances on the landscape (e.g., improved forage) may improve remaining Sonoran pronghorn habitat. Antilocapra americana sonoriensis, Barry M. Goldwater Air Force Range, disturbed habitat, habitat availability, habitat use, military activity, Sonoran pronghorn.

  20. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Luketa, Anay; Rudeen, David Keith

    The objective of this work is to assess dispersion distances of a vapor mixture of species released from a railcar containing a tight crude oil. Tight crude oils can have higher levels of light ends as compared to conventional crude oils [1], which if released and dispersed could pose a potential hazard with regards to a flash fire, explosion, and/or asphyxiation. A historical accident involving rail transport in Viareggio, Italy illustrates how the spillage of LPG can lead to severe damage as a result of a propagating vapor cloud [2]. One of 14 railcars was punctured after derailment, releasing aboutmore » 110 m 3 of LPG into a densely populated area (2000 persons/km 2 ). The resulting vapor cloud propagated and infiltrated nearby buildings and houses which were an average of 10 m in height. Ignition of the cloud occurred approximately 100 to 300 seconds after the start of the spill. A flash fire and explosions resulted, killing 31 people. Evidence suggests that most deaths occurred due to the asphyxiation and thermal hazards from the flash fire. Thus, the motivation for this work is to assess if significant vapors can develop from a railcar carrying a tight crude oil and if this cloud could disperse potentially to nearby populations.« less

  1. Terrorist Material Support: An Overview of 18 U.S.C. 2339A and 2339B

    DTIC Science & Technology

    2010-07-19

    child (which also is not a violent act), is an ‘act dangerous to human life.’ And it violates ... 18 U.S.C. §2339A(a), which provides that ‘whoever...United States. Giving money to Hamas, like giving a loaded gun to a child (which also is not a violent act), is an ‘act dangerous to human life.’ And...explosive or incendiary devices, or endangerment of human life by means of weapons, on an aircraft within U.S. jurisdiction) 49 U.S.C. 46506 (homicide or

  2. Space station crew safety alternatives study. Volume 3: Safety impact of human factors

    NASA Technical Reports Server (NTRS)

    Rockoff, L. A.; Raasch, R. F.; Peercy, R. L., Jr.

    1985-01-01

    The first 15 years of accumulated space station concepts for Initial Operational Capability (IOC) during the early 1990's was considered. Twenty-five threats to the space station are identified and selected threats addressed as impacting safety criteria, escape and rescue, and human factors safety concerns. Of the 25 threats identified, eight are discussed including strategy options for threat control: fire, biological or toxic contamination, injury/illness, explosion, loss of pressurization, radiation, meteoroid penetration and debris. Of particular interest here is volume three (of five volumes) pertaining to the safety impact of human factors.

  3. Hydroarchaeology: Measuring the Ancient Human Impact on the Palenque Watershed

    NASA Astrophysics Data System (ADS)

    French, K. D.; Duffy, C. J.

    2010-03-01

    Palenque, one of the best known Classic Maya centers, has what is arguably the most unique and intricate system of water management known anywhere in the Maya Lowlands. Years of archaeological research, including intensive mapping between 1997 and 2000, reveal that this major center, situated on a narrow escarpment at the base of a high mountain range in northern Chiapas, Mexico, began as a modest settlement about AD 100. Then, during the seventh and eighth centuries, Palenque experienced explosive growth, mushrooming into a dense community with an estimated population of 6000 and approximately 1500 structures — residences, palaces, and temples¬ - under a series of powerful rulers. This process of "urban" growth led to obvious changes in landcover. In order to better understand the effects that landcover and climate change have on the availability of water for an ancient city a new approach is required. In this paper we explore a hydroarchaeological approach that utilizes simulated daily paleoclimate data, watershed modeling, and traditional archaeology to view the response of ancient human impact within the watershed surrounding Palenque. There is great potential for watershed-climate modeling in developing plausible scenarios of water use and supply, and the effect of extreme conditions (flood and drought), all of which cannot be fully represented by atmosphere-based climate and weather projections. The first objective of the paper is to test the hypothesis that drought was a major cause for Palenque’s collapse. Did the Maya abandon Palenque in search of water? Secondly, we evaluate the hydraulic design of the water management features at Palenque against extreme meteorological events. How successful was the hydraulic engineering of the Maya in coping with droughts and floods? The archaeological implications for this non-invasive "virtual" method are many, including detecting periods of stress within a community, estimating population by developing caps based on the availability of water, understanding settlement patterns, as well as assisting present local populations in understanding the water cycle of Palenque.

  4. "Fooling fido"--chemical and behavioral studies of pseudo-explosive canine training aids.

    PubMed

    Kranz, William D; Strange, Nicholas A; Goodpaster, John V

    2014-12-01

    Genuine explosive materials are traditionally employed in the training and testing of explosive-detecting canines so that they will respond reliably to these substances. However, challenges arising from the acquisition, storage, handling, and transportation of explosives have given rise to the development of "pseudo-explosive" training aids. These products attempt to emulate the odor of real explosives while remaining inert. Therefore, a canine trained on a pseudo-explosive should respond to its real-life analog. Similarly, a canine trained on an actual explosive should respond to the pseudo-explosive as if it was real. This research tested those assumptions with a focus on three explosives: single-base smokeless powder, 2,4,6-trinitrotoluene (TNT), and a RDX-based plastic explosive (Composition C-4). Using gas chromatography-mass spectrometry with solid phase microextraction as a pre-concentration technique, we determined that the volatile compounds given off by pseudo-explosive products consisted of various solvents, known additives from explosive formulations, and common impurities present in authentic explosives. For example, simulated smokeless powders emitted terpenes, 2,4-dinitrotoluene, diphenylamine, and ethyl centralite. Simulated TNT products emitted 2,4- and 2,6-dinitrotoluene. Simulated C-4 products emitted cyclohexanone, 2-ethyl-1-hexanol, and dimethyldinitrobutane. We also conducted tests to determine whether canines trained on pseudo-explosives are capable of alerting to genuine explosives and vice versa. The results show that canines trained on pseudo-explosives performed poorly at detecting all but the pseudo-explosives they are trained on. Similarly, canines trained on actual explosives performed poorly at detecting all but the actual explosives on which they were trained.

  5. 78 FR 38574 - Technical Amendments to Counter-Terrorism Sanctions Regulations Implemented by OFAC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-27

    ... relieve human suffering, such as food, clothing, or medicine, may be made by, to, or for the benefit of...; explosives; false documentation or identification; communications equipment; computers; electronic or other... medicine, may be made by, to, or for the benefit of, or received from, any specially designated terrorist...

  6. From parasite genomes to one healthy world; are we having fun yet?

    USDA-ARS?s Scientific Manuscript database

    In 1990, the Human Genome Sequencing Project was established. This laid the ground work for an explosion of sequence data that has since followed. As a result of this effort, the first complete genome of an animal, Caenorhabditis elegans was published in 1998. The sequence of Drosophila melanogaster...

  7. Multimedia Learning: Cognitive Individual Differences and Display Design Techniques Predict Transfer Learning with Multimedia Learning Modules

    ERIC Educational Resources Information Center

    Austin, Katherine A.

    2009-01-01

    In the wake of the information explosion and rapidly progressing technology [Mayer, R. E. (2001). "Multimedia learning". Cambridge: University Press] formulated a theory that focused on human cognition, rather than technology capacity and features. By measuring the effect of cognitive individual differences and display design manipulations on…

  8. The Psychology of Learning

    ERIC Educational Resources Information Center

    Rangaswamy, A.; Balasubramanian, P.; Nirmala, R. Sweety

    2007-01-01

    Psychology plays a significant role in the life of each and every human being. Starting from childhood, if psychology of learning is utilized positively it would play a vital role in the building up of a bright career of a child. The explosion of information technology has been exercising far reaching influence on the area of educational…

  9. An Explosion of Creativity in a Remote Egyptian Village.

    ERIC Educational Resources Information Center

    Osman, Siham A.

    1985-01-01

    The Egyptian architect Wissa Wassef believed artistry in crafts to be an innate human characteristic that would be universally expressed under the right conditions, i.e., the practice of the craft from early childhood. When he had Egyptian peasant children with no previous art experience weave tapestries, the results astounded the world. (RM)

  10. EARS: An Online Bibliographic Search and Retrieval System Based on Ordered Explosion.

    ERIC Educational Resources Information Center

    Ramesh, R.; Drury, Colin G.

    1987-01-01

    Provides overview of Ergonomics Abstracts Retrieval System (EARS), an online bibliographic search and retrieval system in the area of human factors engineering. Other online systems are described, the design of EARS based on inverted file organization is explained, and system expansions including a thesaurus are discussed. (Author/LRW)

  11. From ontology selection and semantic web to the integrated information system of food-borne diseases and food safety

    USDA-ARS?s Scientific Manuscript database

    Over the last three decades, the rapid explosion of information and resources on human food-borne diseases and food safety has provided the ability to rapidly determine and interpret the mechanisms of survival and pathogenesis of food-borne pathogens. However, several factors have hindered effective...

  12. [Genotoxicity and toxicity assay of water sampled from the underground nuclear explosion site in the north of the Perm region (Russia)].

    PubMed

    Evseeva, T I; Geras'kin, S A; Shuktomova, I I; Taskaev, A I

    2004-01-01

    The results of our study revealed a local biologically relevant surface water contamination in the radionuclide anomaly in the north of Russia (Perm region) by means of Allium shoenoprasum L. the anaphase-telophase chromosome aberration assay. This radionuclide anomaly was formed in 1971 as a result of an underground nuclear explosion with soil excavation. Specific activities of main dose-forming radionuclides in all examined reservoirs are below intervention levels officially adopted in Russia for drinking water. We found that 90Sr significantly contribute to induction of cytogenetic disturbances. Our previous and described here data suggest that metal ions and radionuclides combined exposure on the various biota species (with the dose below permissible exposure limits for human) may cause substantial biological effects in part be due to synergic response. The findings described here indicated that development of a new concept of radiation protection for humans and biota should be based on the clear understanding of biological effects of low doses of radiation in chronic exposure to multi-pollutant mixtures.

  13. Genotoxicity and cytotoxicity assay of water sampled from the underground nuclear explosion site in the north of the Perm region (Russia).

    PubMed

    Evseeva, Tatiana I; Geras'kin, Stanislav A; Shuktomova, Ida I; Taskaev, Anatoliy I

    2005-01-01

    The results of our study revealed a local biologically relevant surface water contamination in the radionuclide anomaly in the north of Russia (Perm region) by means of Allium schoenoprasum L. anaphase-telophase chromosome aberration assay. This radionuclide anomaly was formed in 1971 as a result of an underground nuclear explosion with soil excavation. Specific activities of main dose-forming radionuclides in all examined reservoirs are below intervention levels officially adopted in Russia for drinking water. We found that (90)Sr significantly contributes to induction of cytogenetic disturbances. Our previous data and the data described here suggest that metal and radionuclide combined exposure (with the dose below permissible exposure limits for human) may cause substantial biological effects. These effects are in part due to synergic response. The findings described here indicated that development of a new concept of radiation protection for humans and biota should be based on the clear understanding of biological effects of low doses of radiation in chronic exposure to multi-pollutant mixtures.

  14. The effect of explosive percentage on underwater explosion energy release of hexanitrohexaazaisowurtzitane and octogen based aluminized explosives

    NASA Astrophysics Data System (ADS)

    Jiao, Qingjie; Wang, Qiushi; Nie, Jianxin; Guo, Xueyong; Zhang, Wei; Fan, Wenqi

    2018-03-01

    To control the explosion energy output by optimizing explosive components is a key requirement in a number of different application areas. The effect of different Al/O Ratio on underwater explosion of aluminized explosives has been studied detailedly. However, the effect of explosive percentage in the same Al/O Ratio is rarely researched, especially for Hexanitrohexaazaisowurtzitane (CL-20) based aluminized explosives. In this study, we performed the underwater explosion experiments with 1.2-kilogram explosives in order to investigate the explosion energy released from CL-20 and Octogen (HMX) based aluminized explosives. The percentage of the explosive varied from 5% to 30% and it is shown that: the shockwave peak pressure (pm) grows gradually; shock wave energy (Es) continues increasing, bubble energy (Eb) increases then decreases peaking at 15% for both formulas, and the total energy (E) and energy release rate (η) peak at 20% for CL-20 and 15% for HMX. This paper outlines the physical mechanism of Eb change under the influence of an aluminium initial reaction temperature and reaction active detonation product percentage coupling. The result shows that CL-20 is superior as a new high explosive and has promising application prospects in the regulation of explosive energy output for underwater explosives.

  15. Computer simulation of explosion crater in dams with different buried depths of explosive

    NASA Astrophysics Data System (ADS)

    Zhang, Zhichao; Ye, Longzhen

    2018-04-01

    Based on multi-material ALE method, this paper conducted a computer simulation on the explosion crater in dams with different buried depths of explosive using LS-DYNA program. The results turn out that the crater size increases with the increase of buried depth of explosive at first, but closed explosion cavity rather than a visible crater is formed when the buried depth of explosive increases to some extent. The soil in the explosion cavity is taken away by the explosion products and the soil under the explosion cavity is compressed with its density increased. The research can provide some reference for the anti-explosion design of dams in the future.

  16. Understanding the Complexities of Food Safety Using a "One Health" Approach.

    PubMed

    Kniel, Kalmia E; Kumar, Deepak; Thakur, Siddhartha

    2018-02-01

    The philosophy of One Health is growing in concept and clarity. The interdependence of human, animal, and environmental health is the basis for the concept of One Health. One Health is a comprehensive approach to ensure the health of people, animals, and the environment through collaborative efforts. Preharvest food safety issues align with the grand concept of One Health. Imagine any food production system, and immediately, parallel images from One Health emerge: for example, transmission of zoonotic diseases, antibiotic residues, or resistance genes in the environment; environmental and animal host reservoirs of disease; challenges with rearing animals and growing fresh produce on the same farm; application and transport of manure or diseased animals. During a recent celebration of #OneHealthDay, information was shared around the globe concerning scientists dedicated to One Health research systems. An ever-growing trade and global commerce system mixed with our incessant desire for food products during the whole year makes it all the more important to take a global view through the One Health lens to solve these growing challenges. The recent explosion of Zika virus around the globe renewed the need for assessing transmissible diseases through the eyes of One Health. It is not good enough to know how a disease affects the human population without a thorough understanding of the environment and vector reservoirs. If 60 to 75% of infectious diseases affecting humans are of animal origin, the need for better One Health research strategies and overdue solutions is imperative.

  17. The Las Vegas Valley Seismic Response Project: Ground Motions in Las Vegas Valley from Nuclear Explosions at the Nevada Test Site

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rodgers, A; Tkalcic, H; McCallen, D

    2005-03-18

    Between 2001-2004 the Las Vegas Seismic Response Project has sought to understand the response of Las Vegas Valley (LVV) to seismic excitation. In this study, the author report the findings of this project with an emphasis on ground motions in LVV from nuclear explosions at the Nevada Test Site (NTS). These ground motions are used to understand building structural response and damage as well as human perception. Historical nuclear explosion observations are augmented with earthquake recordings from a temporary deployment of seismometers to improve spatial coverage of LVV. The nuclear explosions were conducted between 1968 and 1989 and were recordedmore » at various sites within Las Vegas. The data from past nuclear tests were used to constrain ground motions in LVV and to gain a predictive capability of ground motions for possible future nuclear tests at NTS. Analysis of ground motion data includes peak ground motions (accelerations and velocities) and amplification of basin sites relative to hard rock sites (site response). Site response was measured with the Standard Spectral Ratios (SSR) technique relative to hard rock reference sites on the periphery of LVV. The site response curves indicate a strong basin amplification of up to a factor of ten at frequencies between 0.5-2 Hz. Amplifications are strongest in the central and northern portions of LVV, where the basin is deeper than 1 km based on the reported basin depths of Langenheim et al (2001a). They found a strong correlation between amplification and basin depth and shallow shear wave velocities. Amplification below 1 Hz is strongly controlled by slowness-averaged shear velocities to depths of 30 and 100 meters. Depth averaged shear velocities to 10 meters has modest control of amplifications between 1-3 Hz. Modeling reveals that low velocity material in the shallow layers (< 200 m) effectively controls amplification. They developed a method to scale nuclear explosion ground motion time series to sites around LVV that have no historical record of explosions. The method is also used to scale nuclear explosion ground motions to different yields. They also present a range of studies to understand basin structure and response performed on data from the temporary deployment.« less

  18. 27 CFR 555.183 - Importation of plastic explosives on or after April 24, 1997.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... explosives on or after April 24, 1997. 555.183 Section 555.183 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Marking of Plastic Explosives § 555.183 Importation of plastic explosives on or after April 24...

  19. 27 CFR 555.183 - Importation of plastic explosives on or after April 24, 1997.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... explosives on or after April 24, 1997. 555.183 Section 555.183 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Marking of Plastic Explosives § 555.183 Importation of plastic explosives on or after April 24...

  20. 27 CFR 555.183 - Importation of plastic explosives on or after April 24, 1997.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... explosives on or after April 24, 1997. 555.183 Section 555.183 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Marking of Plastic Explosives § 555.183 Importation of plastic explosives on or after April 24...

  1. 27 CFR 555.183 - Importation of plastic explosives on or after April 24, 1997.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... explosives on or after April 24, 1997. 555.183 Section 555.183 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Marking of Plastic Explosives § 555.183 Importation of plastic explosives on or after April 24...

  2. Seismicity and infrasound associated with explosions at Mount St. Helens, 2004-2005: Chapter 6 in A volcano rekindled: the renewed eruption of Mount St. Helens, 2004-2006

    USGS Publications Warehouse

    Moran, Seth C.; McChesney, Patrick J.; Lockhart, Andrew B.; Sherrod, David R.; Scott, William E.; Stauffer, Peter H.

    2008-01-01

    Six explosions occurred during 2004-5 in association with renewed eruptive activity at Mount St. Helens, Washington. Of four explosions in October 2004, none had precursory seismicity and two had explosion-related seismic tremor that marked the end of the explosion. However, seismicity levels dropped following each of the October explosions, providing the primary instrumental means for explosion detection during the initial vent-clearing phase. In contrast, explosions on January 16 and March 8, 2005, produced noticeable seismicity in the form of explosion-related tremor, infrasonic signals, and, in the case of the March 8 explosion, an increase in event size ~2 hours before the explosion. In both 2005 cases seismic tremor appeared before any infrasonic signals and was best recorded on stations located within the crater. These explosions demonstrated that reliable explosion detection at volcanoes like Mount St. Helens requires seismic stations within 1-2 km of the vent and stations with multiple acoustic sensors.

  3. Noise-induced shifts in the population model with a weak Allee effect

    NASA Astrophysics Data System (ADS)

    Bashkirtseva, Irina; Ryashko, Lev

    2018-02-01

    We consider the Truscott-Brindley system of interacting phyto- and zooplankton populations with a weak Allee effect. We add a random noise to the parameter of the prey carrying capacity, and study how the noise affects the dynamic behavior of this nonlinear prey-predator model. Phenomena of the stochastic excitement and noise-induced shifts in zones of the Andronov-Hopf bifurcation and Canard explosion are analyzed on the base of the direct numerical simulation and stochastic sensitivity functions technique. A relationship of these phenomena with transitions between order and chaos is discussed.

  4. Geriatric restorative care - the need, the demand and the challenges

    PubMed Central

    Nadig, Roopa R; Usha, G; Kumar, Vinod; Rao, Raghoothama; Bugalia, Anupriya

    2011-01-01

    Increased life expectancy is causing an explosion of the aging population that will continue now and in the foreseeable future. Improved quality of life at old age will demand tooth retention and consequently the need for restorative care. Retaining teeth disease free and maintaining them amidst multitude of risk factors associated with old age, is a multi- faceted challenge. This review article discusses the etiology of various dental diseases seen in older dentate population and their management keeping in mind the special needs of these matured people, so as to render a professional service that is sensitive and caring. PMID:22025819

  5. A follow-up study of airway symptoms and lung function among residents and workers 5.5 years after an oil tank explosion.

    PubMed

    Granslo, Jens-Tore; Bråtveit, Magne; Hollund, Bjørg Eli; Lygre, Stein Håkon Låstad; Svanes, Cecilie; Moen, Bente Elisabeth

    2017-01-17

    Assess if people who lived or worked in an area polluted after an oil tank explosion had persistent respiratory health impairment as compared to a non-exposed population 5.5 years after the event. A follow-up study 5.5 years after the explosion, 330 persons aged 18-67 years, compared lung function, lung function decline and airway symptoms among exposed persons (residents <6 km from the accident site or working in the industrial harbour at the time of the explosion) with a non-exposed group (residence >20 km away). Also men in the exposed group who had participated in accident related tasks (firefighting or clean-up of pollution) were compared with men who did not. Data were analysed using Poisson regression, adjusted for smoking, occupational exposure, atopy and age. Exposed men who had participated in accident related tasks had higher prevalence of lower airway symptoms after 5.5 years (n = 24 [73%]) than non-exposed men (28 [48%]), (adjusted relative risk 1.51 [95% confidence interval 1.07, 2.14]). Among men who participated in accident related tasks FEV 1 decline was 48 mL per year, and 12 mL among men who did not (adjusted difference -34 mL per year [-67 mL, -1 mL]), and at follow-up FEV 1 /FVC ratio was 71.4 and 74.2% respectively, (adjusted difference -3.0% [-6.0, 0.0%]). Residents and workers had more airway symptoms and impaired lung function 5.5 years after an oil tank explosion, most significant for a group of men engaged in firefighting and clean-up of pollution after the accident. Public health authorities should be aware of long-term consequences after such accidents.

  6. Rootless Cones on Mars: A Consequence of Lava-Ground Ice Interaction

    NASA Technical Reports Server (NTRS)

    Fagents, S. A.; Greeley, R.; Lanagan, P.

    2002-01-01

    Fields of small cratered cones on Mars are interpreted to have formed by rootless eruptions due to explosive interaction of lava with ground ice contained within the regolith beneath the flow. Melting and vaporization of the ice, and subsequent explosive expansion of the vapour, act to excavate the lava and construct a rootless cone around the explosion site. Similar features are found in Iceland, where flowing lava encountered water-saturated substrates. The martian cones have basal diameters of c. 30-1000 m and are located predominantly in the northern volcanic plains. High-resolution Mars Orbiter Camera images offer significant improvements over Viking data for interpretation of cone origins. A new model of the dynamics of cone formation indicates that very modest amounts of water ice are required to initiate and sustain the explosive interactions that produced the observed features. This is consistent with the likely low availability of water ice in the martian regolith. The scarcity of impact craters on many of the host lava flows indicates very young ages, suggesting that ground ice was present as recently as less than 10 - l00 Ma, and may persist today. Rootless cones therefore act as a spatial and temporal probe of the distribution of ground ice on Mars, which is of key significance in understanding the evolution of the martian climate. The location of water in liquid or solid form is of great importance to future robotic and human exploration strategies, and to the search for extraterrestrial life.

  7. Numerical Simulation using VolcFlow for Pyroclastic Density Currents by Explosive Eruption of Mt. Baekdu, Korea

    NASA Astrophysics Data System (ADS)

    Yun, S. H.; Chang, C.

    2015-12-01

    It is the numerical simulation using a VolcFlow model to determine the runout range of pyroclastic density currents where an eruption column had been formed by the explosive Plinian eruption and the collapse of the column had caused to occur on Mt. Baekdu. We assumed that the most realistic way for the simulation of a sustained volcanic column is to modify the topography with a cone above the crater to follow expert advice from Dr. Karim Kelfoun, the developer of VolcFlow. Then we set the radius and height of the cone, the volume of pyroclastic flow, and the duration and simulation time accoding to the volcanic explosivity index (VEI). Also we set the yield stress as 5,000 Pa, 10,000 Pa, 15,000 Pa, the basal friction angle as 3°, 5°, 10°, respectively. As the simulation results, the longest runout range was 2.3 km, 9.1 km, 14.4 km, 18.6 km, 23.4 km from VEI 3 to VEI 7, respectively. It can be used as a very important material to predict the impact range of pyroclastic density currents and to minimize human and material damages caused by pyroclastic density currents derived from the future explosive eruption of Mt. Baekdu. This research was supported by a grant 'Development of Advanced Volcanic Disaster Response System considering Potential Volcanic Risk around Korea' [MPSS-NH-2015-81] from the Natural Hazard Mitigation Research Group, National Emergency Management Agency of Korea.

  8. Enzymatic redox properties of novel nitrotriazole explosives implications for their toxicity.

    PubMed

    Sarlauskas, Jonas; Nemeikaite-Ceniene, Ausra; Anusevicius, Zilvinas; Miseviciene, Lina; Maroziene, Audrone; Markevicius, Arvydas; Cenas, Narimantas

    2004-01-01

    The toxicity of conventional nitroaromatic explosives like 2,4,6-trinitrotoluene (TNT) is caused by their enzymatic free radical formation with the subsequent oxidative stress, the formation of alkylating nitroso and/or hydroxylamino metabolites, and oxyhemoglobin oxidation into methemoglobin. In order to get an insight into the mechanisms of toxicity of the novel explosives NTO (5-nitro-1,2,4-triazol-3-one) and ANTA (5-nitro-1,2,4-triazol-3-amine), we examined their reactions with the single-electron transferring flavoenzymes NADPH: cytochrome P-450 reductase and ferredoxin:NADP+ reductase, two-electron transferring flavoenzymes mammalian NAD(P)H:quinone oxidoreductase (DT-diaphorase), and Enterobacter cloacae NAD(P)H:nitroreductase, and their reactions with oxyhemoglobin. The reactivity of NTO and ANTA in the above reactions was markedly lower than that of TNT. The toxicity of NTO and ANTA in bovine leukemia virus-transformed lamb kidney fibroblasts (line FLK) was partly prevented by desferrioxamine and the antioxidant N,N'-diphenyl-p-phenylene diamine, and potentiated by 1,3-bis-(2-chloroethyl)-1-nitrosourea. This points to the involvement of oxidative stress in their cytotoxicity, presumably to the redox cycling of free radicals. The FLK cell line cytotoxicity and the methemoglobin formation in isolated human erythrocytes of NTO and ANTA were also markedly lower than those of TNT, and similar to those of nitrobenzene. Taken together, our data demonstrate that the low toxicity of nitrotriazole explosives may be attributed to their low electron-accepting properties.

  9. Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences.

    PubMed

    Nasser, Waleed; Beres, Stephen B; Olsen, Randall J; Dean, Melissa A; Rice, Kelsey A; Long, S Wesley; Kristinsson, Karl G; Gottfredsson, Magnus; Vuopio, Jaana; Raisanen, Kati; Caugant, Dominique A; Steinbakk, Martin; Low, Donald E; McGeer, Allison; Darenberg, Jessica; Henriques-Normark, Birgitta; Van Beneden, Chris A; Hoffmann, Steen; Musser, James M

    2014-04-29

    We sequenced the genomes of 3,615 strains of serotype Emm protein 1 (M1) group A Streptococcus to unravel the nature and timing of molecular events contributing to the emergence, dissemination, and genetic diversification of an unusually virulent clone that now causes epidemic human infections worldwide. We discovered that the contemporary epidemic clone emerged in stepwise fashion from a precursor cell that first contained the phage encoding an extracellular DNase virulence factor (streptococcal DNase D2, SdaD2) and subsequently acquired the phage encoding the SpeA1 variant of the streptococcal pyrogenic exotoxin A superantigen. The SpeA2 toxin variant evolved from SpeA1 by a single-nucleotide change in the M1 progenitor strain before acquisition by horizontal gene transfer of a large chromosomal region encoding secreted toxins NAD(+)-glycohydrolase and streptolysin O. Acquisition of this 36-kb region in the early 1980s into just one cell containing the phage-encoded sdaD2 and speA2 genes was the final major molecular event preceding the emergence and rapid intercontinental spread of the contemporary epidemic clone. Thus, we resolve a decades-old controversy about the type and sequence of genomic alterations that produced this explosive epidemic. Analysis of comprehensive, population-based contemporary invasive strains from seven countries identified strong patterns of temporal population structure. Compared with a preepidemic reference strain, the contemporary clone is significantly more virulent in nonhuman primate models of pharyngitis and necrotizing fasciitis. A key finding is that the molecular evolutionary events transpiring in just one bacterial cell ultimately have produced millions of human infections worldwide.

  10. Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences

    PubMed Central

    Nasser, Waleed; Beres, Stephen B.; Olsen, Randall J.; Dean, Melissa A.; Rice, Kelsey A.; Long, S. Wesley; Kristinsson, Karl G.; Gottfredsson, Magnus; Vuopio, Jaana; Raisanen, Kati; Caugant, Dominique A.; Steinbakk, Martin; Low, Donald E.; McGeer, Allison; Darenberg, Jessica; Henriques-Normark, Birgitta; Van Beneden, Chris A.; Hoffmann, Steen; Musser, James M.

    2014-01-01

    We sequenced the genomes of 3,615 strains of serotype Emm protein 1 (M1) group A Streptococcus to unravel the nature and timing of molecular events contributing to the emergence, dissemination, and genetic diversification of an unusually virulent clone that now causes epidemic human infections worldwide. We discovered that the contemporary epidemic clone emerged in stepwise fashion from a precursor cell that first contained the phage encoding an extracellular DNase virulence factor (streptococcal DNase D2, SdaD2) and subsequently acquired the phage encoding the SpeA1 variant of the streptococcal pyrogenic exotoxin A superantigen. The SpeA2 toxin variant evolved from SpeA1 by a single-nucleotide change in the M1 progenitor strain before acquisition by horizontal gene transfer of a large chromosomal region encoding secreted toxins NAD+-glycohydrolase and streptolysin O. Acquisition of this 36-kb region in the early 1980s into just one cell containing the phage-encoded sdaD2 and speA2 genes was the final major molecular event preceding the emergence and rapid intercontinental spread of the contemporary epidemic clone. Thus, we resolve a decades-old controversy about the type and sequence of genomic alterations that produced this explosive epidemic. Analysis of comprehensive, population-based contemporary invasive strains from seven countries identified strong patterns of temporal population structure. Compared with a preepidemic reference strain, the contemporary clone is significantly more virulent in nonhuman primate models of pharyngitis and necrotizing fasciitis. A key finding is that the molecular evolutionary events transpiring in just one bacterial cell ultimately have produced millions of human infections worldwide. PMID:24733896

  11. Youngest Stellar Explosion in Our Galaxy Discovered

    NASA Astrophysics Data System (ADS)

    2008-05-01

    Astronomers have found the remains of the youngest supernova, or exploded star, in our Galaxy. The supernova remnant, hidden behind a thick veil of gas and dust, was revealed by the National Science Foundation's Very Large Array (VLA) and NASA's Chandra X-Ray Observatory, which could see through the murk. The object is the first example of a "missing population" of young supernova remnants. 1985 and 2008 VLA Images Move cursor over image to blink. VLA Images of G1.9+0.3 in 1985 and 2008: Circle for size comparison. CREDIT: Green, et al., NRAO/AUI/NSF From observing supernovae in other galaxies, astronomers have estimated that about three such stellar explosions should occur in our Milky Way every century. However, the most recent one known until now occurred around 1680, creating the remnant called Cassiopeia A. The newly-discovered object is the remnant of an explosion only about 140 years ago. "If the supernova rate estimates are correct, there should be the remnants of about 10 supernova explosions in the Milky Way that are younger than Cassiopeia A," said David Green of the University of Cambridge in the UK, who led the VLA study. "It's great to finally track one of them down." Supernova explosions, which mark the violent death of a star, release tremendous amounts of energy and spew heavy elements such as calcium and iron into interstellar space. They thus seed the clouds of gas and dust from which new stars and planets are formed and, through their blast shocks, can even trigger such formation. The lack of evidence for young supernova remnants in the Milky Way had caused astronomers to wonder if our Galaxy, which appears otherwise normal, differed in some unknown way from others. Alternatively, scientists thought that the "missing" Milky Way supernovae perhaps indicated that their understanding of the relationship between supernovae and other galactic processes was in error. The astronomers made their discovery by measuring the expansion of the debris from the star's explosion. They did this by comparing images of the object, called G1.9+0.3, made more than two decades apart. In 1985, astronomers led by Green observed G1.9+0.3 with the VLA and identified it as a supernova remnant. At that time, they estimated its age as between 400 and 1,000 years. It is near the center of our Galaxy, roughly 25,000 light-years from Earth. In 2007, another team of astronomers, led by Stephen Reynolds of North Carolina State University, observed the object with the Chandra X-Ray Observatory. To their surprise, their image showed the object to be about 16 percent larger than in the 1985 VLA image. "This is a huge difference. It means the explosion debris is expanding very quickly, which in turn means the object is much younger than we originally thought," Reynolds explained. However, this expansion measurement came from comparing a radio image to an X-ray image. To make an "apples to apples" comparison, the scientists sought and were quickly granted observing time on the VLA. "I've never seen a large astronomical institution move so fast," said Reynolds. Their new VLA observations confirmed the supernova remnant's rapid expansion. The discovery provides scientists with a valuable source of new information about exploding stars. "Our previous situation was as if someone studying humans could look at babies and at adults, but could not study teenagers. Now, we're filling in that gap," said Reynolds. The object already has provided surprises. The velocities of its explosion debris and extreme energies of its particles are unprecedented. "No other object in the Galaxy has properties like this," said Reynolds. "Finding G1.9+0.3 is extremely important for learning more about how some stars explode and what happens in the aftermath," he added. The discovery was possible because radio and X-ray telescopes, unlike visible-light telescopes, can penetrate the thick clouds of gas and dust in our Galaxy. "Looking out of the Milky Way, we can see some supernova explosions with optical telescopes across half of the Universe, but when they're in this murk, we can miss them in our own cosmic back yard," Reynolds said. "Fortunately, the expanding gas cloud from the explosion shines brightly in radio waves and X-rays for thousands of years. X-ray and radio telescopes can see through all that obscuration and show us what we've been missing," he added. Because of the obscuration, no one could have seen the original explosion 140 years ago. The astronomers are reporting their results in papers published in the Astrophysical Journal Letters and Monthly Notices of the Royal Astronomical Society. Background Information: Supernova Explosions Supernova explosions are the violent death throes of stars. These explosions release in one event as much energy as is being released by all the rest of the stars in a galaxy -- typically 100 billion or so. Supernovae seen in other galaxies can outshine the rest of their galaxy for days. The supernovae that have occurred in our own Galaxy and were not obscured by the gas and dust that obscured G1.9+0.3 have often provided a spectacular sight. Historical records indicate that ancient astronomers noted supernova explosions at least as early as A.D. 393, and probably earlier. The pre-telescopic astronomers Tycho Brahe and Johannes Kepler made extensive observations of supernovae in 1572 and 1604. Chinese astronomers noted that a supernova in 1054 was bright enough to be seen in the daytime. A supernova in 1006 remained visible for two years. Supernovae that result from the deaths of stars much more massive than the Sun enrich the galaxy with chemical elements that are produced in the cores of those stars before they explode. The heavy elements, such as carbon, oxygen, iron, siicon and calcium, that make up planets and their inhabitants were made available by supernova explosions. In addition to enriching the material between stars with heavy elements, supernovae stir up that material through the shock energy of the explosion. This is thought to help trigger the process of star formation in interstellar clouds of gas and dust. Many astronomers believe that our own Solar System is the result of such a supernova shock. The National Radio Astronomy Observatory is a facility of the National Science Foundation, operated under cooperative agreement by Associated Universities, Inc.

  12. Mass retention efficiencies of He accretion onto carbon-oxygen white dwarfs and type Ia supernovae

    NASA Astrophysics Data System (ADS)

    Wu, C.; Wang, B.; Liu, D.; Han, Z.

    2017-07-01

    Context. Type Ia supernovae (SNe Ia) play a crucial role in studying cosmology and galactic chemical evolution. They are thought to be thermonuclear explosions of carbon-oxygen white dwarfs (CO WDs) when their masses reach the Chandrasekar mass limit in binaries. Previous studies have suggested that He novae may be progenitor candidates of SNe Ia. However, the mass retention efficiencies during He nova outbursts are still uncertain. Aims: In this article, we aim to study the mass retention efficiencies of He nova outbursts and to investigate whether SNe Ia can be produced through He nova outbursts. Methods: Using the stellar evolution code Modules for Experiments in Stellar Astrophysics, we simulated a series of multicycle He-layer flashes, in which the initial WD masses range from 0.7 to 1.35 M⊙ with various accretion rates. Results: We obtained the mass retention efficiencies of He nova outbursts for various initial WD masses, which can be used in the binary population synthesis studies. In our simulations, He nova outbursts can increase the mass of the WD to the Chandrasekar mass limit and the explosive carbon burning can be triggered in the center of the WD; this suggests that He nova outbursts can produce SNe Ia. Meanwhile, the mass retention efficiencies in the present work are lower than those of previous studies, which leads to a lower birthrates of SNe Ia through the WD + He star channel. Furthermore, we obtained the elemental abundances distribution at the moment of explosive carbon burning, which can be used as the initial input parameters in studying explosion models of SNe Ia.

  13. Instruction at the Hopkins Marine Station

    DTIC Science & Technology

    1989-09-07

    SEM observation on refertilization of sea urchin eggs. 3:30-3:45 Navdeep Jaikaria Effect of aphidicolin on chromosomal replication and condensation. 3...9:15 Bll Pavan Electropermeabilization and introduction of inhibitors into sea urchin embryos. 9:15-9:30 Robert Padgett Population explosion in the...David Nagajski Hydrostatic pressure effects on sea urchin development 10:15-10:30 Emily Carrington Thermal and osmotic stress in the intertidal red

  14. Assessing Irregular Warfare: A Framework for Intelligence Analysis

    DTIC Science & Technology

    2008-01-01

    AND HEALTH CARE INTERNATIONAL AFFAIRS NATIONAL SECURITY POPULATION AND AGING PUBLIC SAFETY SCIENCE AND TECHNOLOGY SUBSTANCE ABUSE TERRORISM AND...Interim FSTC Foreign Science and Technology Center GMI general military intelligence IED improvised explosive device INSCOM Intelligence and Security...ground forces intelligence in the Department of Defense (DoD).1 NGIC was created in March 1995, when the U.S. Army Foreign Science and Technology

  15. Conflict with China: Prospects, Consequences, and Strategies for Deterrence

    DTIC Science & Technology

    2011-01-01

    Burma / Myanmar . Above and beyond the dangers posed by a clash between the world’s two most populous countries, the presence of nuclear weapons on...Reconnaissance CBRNE Chemical, Biological, Radiological, Nuclear , High-Yield Explosives DMZ Demilitarized Zone DPRK Democratic People’s Republic of Korea EEZ...most concern to the United States. 2 Conflict with China: Prospects, Consequences, and Strategies for Deterrence Occasions for Conflict North Korea

  16. The Post-9/11 G.I. Bill: A Catalyst to Change Service Voluntary Education Programs

    DTIC Science & Technology

    2011-06-17

    another significant consequence to the enrollment explosion. In many instances classroom spaces, dormitories and laboratories had to be expanded to...meet demand. Classrooms filled to capacity and dormitories were inadequate for this new population of students (including the addition of married...even in Afghanistan.5 Whether VolEd participation occurs in a classroom or through Distance Learning, education is a

  17. Chemical analysis kit for the presence of explosives

    DOEpatents

    Eckels, Joel Del [Livermore, CA; Nunes,; Peter, J [Danville, CA; Alcaraz, Armando [Livermore, CA; Whipple, Richard E [Livermore, CA

    2011-05-10

    A tester for testing for explosives associated with a test location comprising a first explosives detecting reagent; a first reagent holder, the first reagent holder containing the first explosives detecting reagent; a second explosives detecting reagent; a second reagent holder, the second reagent holder containing the second explosives detecting reagent; a sample collection unit for exposure to the test location, exposure to the first explosives detecting reagent, and exposure to the second explosives detecting reagent; and a body unit containing a heater for heating the sample collection unit for testing the test location for the explosives.

  18. Threshold Monitoring Maps for Under-Water Explosions

    NASA Astrophysics Data System (ADS)

    Arora, N. S.

    2014-12-01

    Hydro-acoustic energy in the 1-100 Hz range from under-water explosions can easily spread for thousands of miles due to the unique properties of the deep sound channel. This channel, aka SOFAR channel, exists almost everywhere in the earth's oceans where the water has at least 1500m depth. Once the energy is trapped in this channel it spreads out cylindrically, and hence experiences very little loss, as long as there is an unblocked path from source to receiver. Other losses such as absorption due to chemicals in the ocean (mainly boric acid and magnesium sulphate) are also quite minimal at these low frequencies. It is not surprising then that the International Monitoring System (IMS) maintains a global network of hydrophone stations listening on this particular frequency range. The overall objective of our work is to build a probabilistic model to detect and locate under-water explosions using the IMS network. A number of critical pieces for this model, such as travel time predictions, are already well known. We are extending the existing knowledge-base by building the remaining pieces, most crucially the models for transmission losses and detection probabilities. With a complete model for detecting under-water explosions we are able to combine it with our existing model for seismic events, NET-VISA. In the conference we will present threshold monitoring maps for explosions in the earth's oceans. Our premise is that explosive sources release an unknown fraction of their total energy into the SOFAR channel, and this trapped energy determines their detection probability at each of the IMS hydrophone stations. Our threshold monitoring maps compute the minimum amount of energy at each location that must be released into the deep sound channel such that there is a ninety percent probability that at least two of the IMS stations detect the event. We will also present results of our effort to detect and locate hydro-acoustic events. In particular, we will show results from a recent under-water volcanic eruption at the Ahyl Seamount (April-May 2014), and compare our work with the current processing, both automated and human, at the IDC.

  19. Intermittent explosive disorder amongst women in conflict affected Timor-Leste: associations with human rights trauma, ongoing violence, poverty, and injustice.

    PubMed

    Rees, Susan; Silove, Derrick; Verdial, Teresa; Tam, Natalino; Savio, Elisa; Fonseca, Zulmira; Thorpe, Rosamund; Liddell, Belinda; Zwi, Anthony; Tay, Kuowei; Brooks, Robert; Steel, Zachary

    2013-01-01

    Women in conflict-affected countries are at risk of mental disorders such as posttraumatic stress disorder and depression. No studies have investigated the association between experiences of abuse and injustice and explosive anger amongst women in these settings, and the impact of anger on women's health, family relationships and ability to participate in development. A mixed methods study including an epidemiological survey (n = 1513, 92.6% response) and qualitative interviews (n = 77) was conducted in Timor-Leste. The indices measured included Intermittent Explosive Disorder, posttraumatic stress disorder; severe distress; days out of role (the number of days that the person was unable to undertake normal activities); gender-specific trauma; conflict/violence; poverty; and preoccupations with injustice. Women with Intermittent Explosive Disorder (n = 184, 12.2%) were more disabled than those without the disorder (for >5 days out of role, 40.8% versus 31.5%, X(2) (2) = 12.93 p = 0.0016). Multivariable associations with Intermittent Explosive Disorder, controlling for the presence of PTSD, psychological distress and other predictors in the model, included the sense of being sick (OR 1.73; 95% CI 1.08-2.77); victimization as a result of helping the resistance movement (OR 2.33, 95% CI 1.48-3.68); war-related trauma specific to being a woman (OR 1.95, 95%, CI 1.09-3.50); ongoing family violence and community conflict (OR 1.88, 95% CI 1.27-2.77); extreme poverty (OR 1.23, 95%, CI 1.08-1.39); and distressing preoccupations with injustice (relating to 2/3 historical periods, OR 2.10, 95% CI 1.35-3.28). In the qualitative study, women elaborated on the determinants of anger and its impact on their health, family and community functioning, child-rearing, and capacity to engage in development. Women reflected on the strategies that might help them overcome their anger. Intermittent Explosive Disorder is prevalent and disabling amongst women in conflict-affected Timor-Leste, impacting on their health, child-rearing and ability to participate fully in socio-economic development.

  20. Explosive simulants for testing explosive detection systems

    DOEpatents

    Kury, John W.; Anderson, Brian L.

    1999-09-28

    Explosives simulants that include non-explosive components are disclosed that facilitate testing of equipment designed to remotely detect explosives. The simulants are non-explosive, non-hazardous materials that can be safely handled without any significant precautions. The simulants imitate real explosives in terms of mass density, effective atomic number, x-ray transmission properties, and physical form, including moldable plastics and emulsions/gels.

  1. Non-detonable and non-explosive explosive simulators

    DOEpatents

    Simpson, Randall L.; Pruneda, Cesar O.

    1997-01-01

    A simulator which is chemically equivalent to an explosive, but is not detonable or explodable. The simulator is a combination of an explosive material with an inert material, either in a matrix or as a coating, where the explosive has a high surface ratio but small volume ratio. The simulator has particular use in the training of explosives detecting dogs, calibrating analytical instruments which are sensitive to either vapor or elemental composition, or other applications where the hazards associated with explosives is undesirable but where chemical and/or elemental equivalence is required. The explosive simulants may be fabricated by different techniques. A first method involves the use of standard slurry coatings to produce a material with a very high binder to explosive ratio without masking the explosive vapor, and a second method involves coating inert substrates with thin layers of explosive.

  2. The Expansion of Explosives Safety Education for the 21st Century

    DTIC Science & Technology

    2010-07-01

    shape charges, explosive welding, thermite reaction – Sensitivity testing: drop hammer, electrospark discharge, friction – Physics of explosives, history... ATF ) • Phytoremediation workers use plants to remove explosives from soil and render the explosives harmless • Sales of explosives detection

  3. Quantitative understanding of explosive stimulus transfer

    NASA Technical Reports Server (NTRS)

    Schimmel, M. L.

    1973-01-01

    The mechanisms of detonation transfer across hermetically sealed interfaces created by necessary interruptions in high explosive trains, such as at detonators to explosive columns, field joints in explosive columns, and components of munitions fuse trains are demostrated. Reliability of detonation transfer is limited by minimizing explosive quantities, the use of intensitive explosives for safety, and requirements to propagate across gaps and angles dictated by installation and production restraints. The major detonation transfer variables studied were: explosive quanity, sensitivity, and thickness, and the separation distances between donor and acceptor explosives.

  4. The characterization and evaluation of accidental explosions

    NASA Technical Reports Server (NTRS)

    Strehlow, R. A.; Baker, W. E.

    1975-01-01

    Accidental explosions are discussed from a number of viewpoints. First, all accidental explosions, intentional explosions and natural explosions are characterized by type. Second, the nature of the blast wave produced by an ideal (point source or HE) explosion is discussed to form a basis for describing how other explosion processes yield deviations from ideal blast wave behavior. The current status blast damage mechanism evaluation is also discussed. Third, the current status of our understanding of each different category of accidental explosions is discussed in some detail.

  5. Quantitative Risk Analysis on the Transport of Dangerous Goods Through a Bi-Directional Road Tunnel.

    PubMed

    Caliendo, Ciro; De Guglielmo, Maria Luisa

    2017-01-01

    A quantitative risk analysis (QRA) regarding dangerous goods vehicles (DGVs) running through road tunnels was set up. Peak hourly traffic volumes (VHP), percentage of heavy goods vehicles (HGVs), and failure of the emergency ventilation system were investigated in order to assess their impact on the risk level. The risk associated with an alternative route running completely in the open air and passing through a highly populated urban area was also evaluated. The results in terms of social risk, as F/N curves, show an increased risk level with an increase the VHP, the percentage of HGVs, and a failure of the emergency ventilation system. The risk curves of the tunnel investigated were found to lie both above and below those of the alternative route running in the open air depending on the type of dangerous goods transported. In particular, risk was found to be greater in the tunnel for two fire scenarios (no explosion). In contrast, the risk level for the exposed population was found to be greater for the alternative route in three possible accident scenarios associated with explosions and toxic releases. Therefore, one should be wary before stating that for the transport of dangerous products an itinerary running completely in the open air might be used if the latter passes through a populated area. The QRA may help decisionmakers both to implement additional safety measures and to understand whether to allow, forbid, or limit circulation of DGVs. © 2016 Society for Risk Analysis.

  6. Impact of Stellar Convection Criteria on the Nucleosynthetic Yields of Population III Supernovae.

    NASA Astrophysics Data System (ADS)

    Teffs, Jacob; Young, Tim; Lawlor, Tim

    2018-01-01

    A grid of 15-80 solar mass Z=0 stellar models are evolved to pre-core collapse using the stellar evolution code BRAHAMA. Each initial zero-age main sequence mass model star is evolved with two different convection criteria, Ledoux and Schwarzchild. The choice of convection produces significant changes in the evolutionary model tracks on the HR diagram, mass loss, and interior core and envelope structures. At onset of core collapse, a SNe explosion is initiated using a one-dimensional radiation-hydrodynamics code and followed for 400 days. The explosion energy is varied between 1-10 foes depending on the model as there are no observationally determined energies for population III supernovae. Due to structure differences, the Schwarzchild models resemble Type II-P SNe in their lightcurve while the Ledoux models resemble SN1987a, a Type IIpec. The nucleosynthesis is calculated using TORCH, a 3,208 isotope network, in a post process method using the hydrodynamic history. The Ledoux models have, on average, higher yields for elements above Fe compared to the Schwarzchild. Using a Salpeter IMF and other recently published population III IMF’s, the net integrated yields per solar mass are calculated and compared to published theoretical results and to published observations of extremely metal poor halo stars of [Fe/H] < -3. Preliminary results show the lower mass models of both criteria show similar trends to the extremely metal poor halo stars but more work and analysis is required.

  7. A Rose by Naming: How We May Learn How to Do It

    ERIC Educational Resources Information Center

    Greer, R. Douglas; Longano, Jennifer

    2010-01-01

    Naming appears to be the source of the explosion in language development and involves the integration of the initially separate listener and speaker responses. This integration has a role in the development of reading, writing, and the following and construction of verbal algorithms that make types of complex human behavior possible. Considerable…

  8. 40 CFR 267.51 - What is the purpose of the contingency plan and how do I use it?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE... facility. You must design the plan to minimize hazards to human health or the environment from fires, explosions, or any unplanned sudden or non-sudden release of hazardous waste or hazardous waste constituents...

  9. 40 CFR 267.51 - What is the purpose of the contingency plan and how do I use it?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE... facility. You must design the plan to minimize hazards to human health or the environment from fires, explosions, or any unplanned sudden or non-sudden release of hazardous waste or hazardous waste constituents...

  10. 40 CFR 267.51 - What is the purpose of the contingency plan and how do I use it?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE... facility. You must design the plan to minimize hazards to human health or the environment from fires, explosions, or any unplanned sudden or non-sudden release of hazardous waste or hazardous waste constituents...

  11. 40 CFR 267.51 - What is the purpose of the contingency plan and how do I use it?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE... facility. You must design the plan to minimize hazards to human health or the environment from fires, explosions, or any unplanned sudden or non-sudden release of hazardous waste or hazardous waste constituents...

  12. Applying Digital Sensor Technology: A Problem-Solving Approach

    ERIC Educational Resources Information Center

    Seedhouse, Paul; Knight, Dawn

    2016-01-01

    There is currently an explosion in the number and range of new devices coming onto the technology market that use digital sensor technology to track aspects of human behaviour. In this article, we present and exemplify a three-stage model for the application of digital sensor technology in applied linguistics that we have developed, namely,…

  13. US Geological Survey begins seismic ground response experiments in Washington State

    USGS Publications Warehouse

    Tarr, A.C.; King, K.W.

    1988-01-01

    This article briefly describes the experimental monitoring of minor seismic features caused by distant nuclear explosions, mining blasts and rhythmic human pushing against wooden homes. Some means of response prediction are outlined in Washington State and some effects of seismic amplification by weak clayey sediments are described. The results of several experiments are described. -A.Scarth

  14. The Promise of New Ideas and New Technology for Improving Teaching and Learning

    ERIC Educational Resources Information Center

    Novak, Joseph D.

    2003-01-01

    There have been enormous advances in our understanding of human learning in the past three decades. There have also been important advances in our understanding of the nature of knowledge and new knowledge creation. These advances, when combined with the explosive development of the Internet and other technologies, permit advances in educational…

  15. Real-time detection and characterization of nuclear explosion using broadband analyses of regional seismic stations

    NASA Astrophysics Data System (ADS)

    Prastowo, T.; Madlazim

    2018-01-01

    This preliminary study aims to propose a new method of real-time detection and characterization of nuclear explosions by analyzing broadband seismic waveforms acquired from a network of regional seismic stations. Signal identification generated by a nuclear test was differentiated from natural sources of either earthquakes or other natural seismo-tectonic events by verifying crucial parameters, namely source depth, type of first motion, and P-wave domination of the broadband seismic wavesunder consideration. We examined and analyzed a recently hypothetical nuclear test performed by the North Koreangovernment that occurred on September 3, 2017 as a vital point to study. From spectral analyses, we found that the source of corresponding signals associated with detonations of the latest underground nuclear test was at a much shallower depth below the surface relatively compared with that of natural earthquakes, the suspected nuclear explosions produced compressional waves with radially directed outward from the source for their first motions, and the waves were only dominated by P-components. The results are then discussed in the context of potential uses of the proposed methodology for human-induced disaster early warning system and/or the need of rapid response purposes for minimizing the disaster risks.

  16. Convolutional neural network based side attack explosive hazard detection in three dimensional voxel radar

    NASA Astrophysics Data System (ADS)

    Brockner, Blake; Veal, Charlie; Dowdy, Joshua; Anderson, Derek T.; Williams, Kathryn; Luke, Robert; Sheen, David

    2018-04-01

    The identification followed by avoidance or removal of explosive hazards in past and/or present conflict zones is a serious threat for both civilian and military personnel. This is a challenging task as variability exists with respect to the objects, their environment and emplacement context, to name a few factors. A goal is the development of automatic or human-in-the-loop sensor technologies that leverage signal processing, data fusion and machine learning. Herein, we explore the detection of side attack explosive hazards (SAEHs) in three dimensional voxel space radar via different shallow and deep convolutional neural network (CNN) architectures. Dimensionality reduction is performed by using multiple projected images versus the raw three dimensional voxel data, which leads to noteworthy savings in input size and associated network hyperparameters. Last, we explore the accuracy and interpretation of solutions learned via random versus intelligent network weight initialization. Experiments are provided on a U.S. Army data set collected over different times, weather conditions, target types and concealments. Preliminary results indicate that deep learning can perform as good as, if not better, than a skilled domain expert, even in light of limited training data with a class imbalance.

  17. Non-detonable and non-explosive explosive simulators

    DOEpatents

    Simpson, R.L.; Pruneda, C.O.

    1997-07-15

    A simulator which is chemically equivalent to an explosive, but is not detonable or explodable is disclosed. The simulator is a combination of an explosive material with an inert material, either in a matrix or as a coating, where the explosive has a high surface ratio but small volume ratio. The simulator has particular use in the training of explosives detecting dogs, calibrating analytical instruments which are sensitive to either vapor or elemental composition, or other applications where the hazards associated with explosives is undesirable but where chemical and/or elemental equivalence is required. The explosive simulants may be fabricated by different techniques. A first method involves the use of standard slurry coatings to produce a material with a very high binder to explosive ratio without masking the explosive vapor, and a second method involves coating inert substrates with thin layers of explosive. 11 figs.

  18. Thermal explosion violence of HMX-based explosives -- effect of composition, confinement and phase transition using the scaled thermal explosion experiment

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Maienschein, J L; Wardell, J F; Reaugh, J E

    We developed the Scaled Thermal Explosion Experiment (STEX) to provide a database of reaction violence from thermal explosion of explosives of interest. A cylinder of explosive, 1, 2 or 4 inches in diameter, is confined in a steel cylinder with heavy end caps, and heated under controlled conditions until it explodes. Reaction violence is quantified by micropower radar measurement of the cylinder wall velocity, and by strain gauge data at reaction onset. Here we describe the test concept and design, show that the conditions are well understood, and present initial data with HMX-based explosives. The HMX results show that anmore » explosive with high binder content yields less-violent reactions that an explosive with low binder content, and that the HMX phase at the time of explosion plays a key role in reaction violence.« less

  19. Biomonitoring of 2,4,6-trinitrotoluene and degradation products in the marine environment with transplanted blue mussels (M. edulis).

    PubMed

    Strehse, Jennifer S; Appel, Daniel; Geist, Catharina; Martin, Hans-Jörg; Maser, Edmund

    2017-09-01

    Since World War I considerable amounts of warfare material have been dumped at sea worldwide, but little is known about the fate of the explosive components in the marine environment. Sea dumped munitions are able to contaminate the surroundings because of the release of explosive chemicals due to corrosion and breaching or by detonation after blast-operations. This implies the risk of accumulation of toxic compounds in human and wildlife food chains. With the help of divers, we performed an active biomonitoring study with transplanted blue mussels (M. edulis) in a burdened area (Kolberger Heide, Germany) with explosive compounds near blast craters over an exposure time of 93days. With this biomonitoring system, we could show that blue mussels accumulate 2,4,6-trinitrotoluene (TNT) and its metabolites 2-amino-4,6-dinitrotoluene (2-ADNT) and 4-amino-2,6-dinitrotoluene (4-ADNT) in their tissues. In all mussels deployed at the ground, we found a body burden with 2-ADNT of 103.75±12.77ng/g wet weight and with 4-ADNT of 131.31±9.53ng/g wet weight. TNT itself has been found in six mussels with an average concentration of 31.04±3.26ng/g mussel wet weight. In the mussels positioned at one meter above the ground no TNT nor 2-ADNT could be detected, but 4-ADNT was found in all samples with an average concentration of 8.71±2.88ng/g mussel wet weight. To the best of our knowledge, this is the first study using blue mussels M. edulis as an active biomonitoring system for TNT and its metabolites 2-ADNT and 4-ADNT in a free field experiment in a burdened area. Moreover, with this system, we unequivocally proved that these toxic explosives accumulate in the marine biota resp. in the marine food chain, thereby posing a possible risk to the marine ecosphere and human health. Copyright © 2017 Elsevier B.V. All rights reserved.

  20. A New and Improved Model of the Near-Earth Object Population

    NASA Astrophysics Data System (ADS)

    Bottke, W. F., Jr.; Granvik, M.; Morbidelli, A.; Jedicke, R.; Bolin, B.; Beshore, E. C.; Vokrouhlicky, D.; Nesvorny, D.; Michel, P.

    2014-12-01

    This is a golden age for near-Earth Object (NEO) research. We have discovered some 90% of the most threatening NEOs, while ongoing surveys are finding many sub-km NEOs as well. NEO physical characterization studies by missions, space- and ground-based observatories are also revolutionizing our ideas about what NEOs are like. President Obama announced on April 15, 2010 that NASA would send astronauts to an NEA by 2025; this remains Administration policy. The Feb. 15, 2013 explosion of an NEO over Chelyabinsk, Russia, has further boosted interest in NEOs. This increasing interest, and a vast array of new data, have led us to re-investigate the debiased orbital and absolute magnitude distribution of the NEO population. Such models are asboluetly needed to make accurate predictions about NEOs that are likely exploration targets for human and robotic spacecraft. Using the methods of Bottke et al. (2002), we numerically tracked a large unbiased sample of asteroids escaping the main belt and TNO populations in order to locate all possible NEO source regions. From here, we recorded the orbital evolution of the bodies that entering the NEO region; their evolutionary pathways were used to create so-called NEO residence-time distributions. They were combined with the calculated observational selection effects for the Catalina Sky Survey, with the model fit to 4,550 NEOs (15 < H < 25) detected by the Catalina Sky Survey's Mt. Lemmon (G96) and Catalina (703) stations between 2005-2012. Our best fit case beautifully reproduces observations and provides us with a new and improved NEO model population. We find our results are in good agreement with the Bottke et al. (2002) model, but we also find many intriguing differences as well: (i) There is an increasing preference for small NEOs to come from the central main belt; (ii) Many low-perihelion-distance NEOs are apparently missing -- we suspect many were removed by a physical destruction mechanism; (iii) We are largely complete in H < 18 Atens and Amors, but we are still missing a good fraction of Apollo NEOs. In our talk, we will discuss our latest findings and will describe the nature of the NEO populations accessible by both ARM and human missions.

  1. Leveraging Game Consoles for the Delivery of TBI Rehabilitation

    NASA Technical Reports Server (NTRS)

    Super, Taryn; Mastaglio, Thomas; Shen, Yuzhong; Walker, Robert

    2011-01-01

    Military personnel are at a greater risk for traumatic brain injury (TBI) than the civilian population. In addition, the increase in exposure to explosives, i.e. , improvised explosive devices, in the Afghanistan and Iraq wars, along with more effective body armor, has resulted in far more surviving casualties suffering from TBI than in previous wars. This effort presents the results of a feasibility study and early prototype of a brain injury rehabilitation delivery system (BIRDS). BIRDS is designed to provide medical personnel treating TBI with a capability to prescribe game activities for patients to execute using a commercially available game console, either in a clinical setting or in their homes. These therapeutic activities will contribute to recovery or remediation of the patients' cognitive dysfunctions. Solutions such as this that provide new applications for existing platforms have significant potential to address the growing incidence of TBI today.

  2. High-sensitivity detection of triacetone triperoxide (TATP) and its precursor acetone

    NASA Astrophysics Data System (ADS)

    Dunayevskiy, Ilya; Tsekoun, Alexei; Prasanna, Manu; Go, Rowel; Patel, C. Kumar N.

    2007-09-01

    Triacetone triperoxide (C9H18O6, molecular mass of 222.24 g/mol) (TATP) is a powerful explosive that is easy to synthesize using commonly available household chemicals, acetone, and hydrogen peroxide 1 2. Because of the simplicity of its synthesis, TATP is often the explosive of choice for terrorists, including suicide bombers. For providing safety to the population, early detection of TATP and isolation of such individuals are essential. We report unambiguous, high-sensitivity detection of TATP and its precursor, acetone, using room-temperature quantum cascade laser photoacoustic spectroscopy (QCL-PAS). The available sensitivity is such that TATP, carried on a person (at a nominal body temperature of 37 °C), should be detectable at some distance. The combination of demonstrated detection of TATP and acetone should be ideal for screening at airports and other public places for providing increased public safety.

  3. Supernova Explosions, Nucleosynthesis, and Cosmic Chemical Evolution

    NASA Astrophysics Data System (ADS)

    Truran, James W.

    2006-08-01

    The Universe emerged from its first three minutes with a composition consisting of hydrogen, deuterium, 3He, 4He, and 7Li. These isotopes constitute the primordial compositions of galaxies. Within galaxies, the synthesis of heavier elements from carbon through uranium is understood to occur during the normal evolution of stars and in supernova explosions of Types I and II. This history is written in the compositions of the stars and gas in our Milky Way Galaxy and other galaxies. The contributions both from massive stars (M>10 Msolar) and associated Type II supernovae and from Type Ia (thermonuclear) supernovae are particularly noteworthy. We review both the nuclear processes by which this occurs and the compositions of the stellar components of our Galaxy as a function of time which reflect these nucleosynthesis processes. We then discuss how such observations inform us of the nature of the earliest stellar populations and of the abundance history of the Cosmos.

  4. Species-specific differences in peroxisome proliferation, catalase, and SOD2 upregulation as well as toxicity in human, mouse, and rat hepatoma cells induced by the explosive and environmental pollutant 2,4,6-trinitrotoluene.

    PubMed

    Naumenko, Ekaterina Anatolevna; Ahlemeyer, Barbara; Baumgart-Vogt, Eveline

    2017-03-01

    2,4,6-Trinitrotoluene (TNT) has been widely used as an explosive substance and its toxicity is still of interest as it persisted in polluted areas. TNT is metabolized in hepatocytes which are prone to its toxicity. Since analysis of the human liver or hepatocytes is restricted due to ethical reasons, we investigated the effects of TNT on cell viability, reactive oxygen species (ROS) production, peroxisome proliferation, and antioxidative enzymes in human (HepG2), mouse (Hepa 1-6), and rat (H4IIEC3) hepatoma cell lines. Under control conditions, hepatoma cells of all three species were highly comparable exhibiting identical proliferation rates and distribution of their cell cycle phases. However, we found strong differences in TNT toxicity with the lowest IC 50 values (highest cell death rate) for rat cells, whereas human and mouse cells were three to sevenfold less sensitive. Moreover, a strong decrease in cellular dehydrogenase activity (MTT assay) and increased ROS levels were noted. TNT caused peroxisome proliferation with rat hepatoma cells being most responsive followed by those from mouse and human. Under control conditions, rat cells contained fivefold higher peroxisomal catalase and mitochondrial SOD2 activities and a twofold higher capacity to reduce MTT than human and mouse cells. TNT treatment caused an increase in catalase and SOD2 mRNA and protein levels in human and mouse, but not in rat cells. Similarly, human and mouse cells upregulated SOD2 activity, whereas rat cells failed therein. We conclude that TNT induced oxidative stress, peroxisome proliferation and mitochondrial damage which are highest in rat cells rendering them most susceptible toward TNT. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 989-1006, 2017. © 2016 Wiley Periodicals, Inc.

  5. Steam explosion pretreatment of softwood: the effect of the explosive decompression on enzymatic digestibility.

    PubMed

    Pielhop, Thomas; Amgarten, Janick; von Rohr, Philipp Rudolf; Studer, Michael H

    2016-01-01

    Steam explosion pretreatment has been examined in many studies for enhancing the enzymatic digestibility of lignocellulosic biomass and is currently the most common pretreatment method in commercial biorefineries. The information available about the effect of the explosive decompression on the biochemical conversion is, however, very limited, and no studies prove that the latter is actually enhanced by the explosion. Hence, it is of great value to discern between the effect of the explosion on the one hand and the steaming on the other hand, to identify their particular influences on enzymatic digestibility. The effect of the explosive decompression in the steam explosion pretreatment of spruce wood chips on their enzymatic cellulose digestibility was studied systematically. The explosion had a high influence on digestibility, improving it by up to 90 % compared to a steam pretreatment without explosion. Two factors were identified to be essentially responsible for the effect of the explosion on enzymatic digestibility: pretreatment severity and pressure difference of the explosion. A higher pretreatment severity can soften up and weaken the lignocellulose structure more, so that the explosion can better break up the biomass and decrease its particle size, which enhances its digestibility. In particular, increasing the pressure difference of the explosion leads to more defibration, a smaller particle size and a better digestibility. Though differences were found in the micro- and nanostructure of exploded and non-exploded biomass, the only influence of the explosion on digestibility was found to be the macroscopic particle size reduction. Steam explosion treatments with a high severity and a high pressure difference of the explosion lead to a comparatively high cellulose digestibility of the-typically very recalcitrant-softwood biomass. This is the first study to show that explosion can enhance the enzymatic digestibility of lignocellulosic biomass. If the enhancing effect of the explosion is thoroughly exploited, even very recalcitrant biomass like softwood can be made enzymatically digestible.

  6. [Acoustic trauma generated by exposure to gun powder].

    PubMed

    Arch-Tirado, Emilio; Garnica-Escamilla, Marco Antonio; Delgado-Hernández, Alhelí; Campos-Muñoz, Teodora; Rodríguez-Rodríguez, Lourdes; Verduzco-Mendoza, Antonio

    2014-01-01

    Noise-induced hearing loss has increased due to factors such as industrialization. It is estimated that one third of the world's population suffers from some degree of hearing loss caused by exposure to high-intensity noise. Exposure to noise can cause disease of various ear structures, especially destruction of outer hair cells, causing varying degrees of hearing lossObjective: To describe the audiological findings in a group of subjects who were exposed to a source of fireworks explosion in the state of Tlaxcala Mexico. We carried out an audiometric study in eight patients admitted to CENIAQ-INR who were exposed to a firecracker explosion. In each subject, airway with conventional pure tone audiometry from 125 to 8000 Hz was assessed using a clinical audiometer (model 622, Minimate, Madsen) Clinical case: Hearing loss at all frequencies was found in all eight patients, from mild to severe in both ears. Audiogram showed decreases from 4000 Hz, diagnosing third-degree acoustic trauma in all patients. The main symptom was reported by patients with tinnitus. Other scenarios in which patients report the presence of tinnitus are acoustic trauma due to use of audio players in symphony orchestra musicians and detonating military firearms. Audiometric assessment is recommended after an explosive accident as an accurate method to determine if there is any hearing impairment.

  7. β-delayed p-decay of proton-rich nuclei ^23Al and ^31Cl and explosive H-burning in novae

    NASA Astrophysics Data System (ADS)

    Trache, L.; Banu, A.; Hardy, J. C.; McCleskey, M.; Simmons, E.; Tabacaru, G.; Tribble, R. E.; Aysto, J.; Jokinen, A.; Saastamoinen, A.; Davinson, T.; Woods, P. J.; Achouri, L.; Roeder, B.

    2008-10-01

    We developed a technique to measure β-delayed proton-decay of proton-rich nuclei produced and separated with MARS at TAMU. In particular, we studied the decay of ^23Al and ^31Cl, both important for understanding explosive H-burning in novae. We have pulsed the beam, implanting the source nuclei moving at about 40 MeV/u in a thin Si strip detector, and then measured β-p and β-γ coincidences simultaneously. The states populated above the proton threshold in ^23Mg and ^31S, respectively, may proton decay. They are resonances in the reaction ^22Na(p,γ)^23Mg (crucial for the depletion of ^22Na in ONe novae) and in ^30P(p,γ)^31S (critical point in explosive H-burning in novae), but the protons emitted have very low energies, starting at about 200 keV, an experimental challenge. The setup and the results are described. The β-decay schemes were established for both nuclei, and IAS identified. The technique has shown a remarkable selectivity to β-delayed charged particle emission and shown to work even at radioactive beam rates of a few pps, for rare isotopes with lifetimes as low as 10s msec.

  8. 27 CFR 70.445 - Commerce in explosives.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2013-04-01 2013-04-01 false Commerce in explosives. 70... Cartridges, and Explosives § 70.445 Commerce in explosives. Part 555 of title 27 CFR contains the regulations..., explosives, (b) Permits for users who buy or transport explosives in interstate or foreign commerce, (c...

  9. 27 CFR 70.445 - Commerce in explosives.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true Commerce in explosives. 70... Cartridges, and Explosives § 70.445 Commerce in explosives. Part 555 of title 27 CFR contains the regulations..., explosives, (b) Permits for users who buy or transport explosives in interstate or foreign commerce, (c...

  10. 27 CFR 70.445 - Commerce in explosives.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Commerce in explosives. 70... Cartridges, and Explosives § 70.445 Commerce in explosives. Part 555 of title 27 CFR contains the regulations..., explosives, (b) Permits for users who buy or transport explosives in interstate or foreign commerce, (c...

  11. 27 CFR 70.445 - Commerce in explosives.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2011-04-01 2011-04-01 false Commerce in explosives. 70... Cartridges, and Explosives § 70.445 Commerce in explosives. Part 555 of title 27 CFR contains the regulations..., explosives, (b) Permits for users who buy or transport explosives in interstate or foreign commerce, (c...

  12. 27 CFR 70.445 - Commerce in explosives.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Commerce in explosives. 70... Cartridges, and Explosives § 70.445 Commerce in explosives. Part 55 of title 27 CFR contains the regulations..., explosives, (b) Permits for users who buy or transport explosives in interstate or foreign commerce, (c...

  13. 27 CFR 555.186 - Seizure or forfeiture.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Marking of Plastic Explosives § 555.186 Seizure or forfeiture. Any plastic explosive that does not contain a detection agent in violation of 18 U... of this chapter for regulations on summary destruction of plastic explosives that do not contain a...

  14. 27 CFR 555.186 - Seizure or forfeiture.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Marking of Plastic Explosives § 555.186 Seizure or forfeiture. Any plastic explosive that does not contain a detection agent in violation of 18 U... of this chapter for regulations on summary destruction of plastic explosives that do not contain a...

  15. 27 CFR 555.186 - Seizure or forfeiture.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Marking of Plastic Explosives § 555.186 Seizure or forfeiture. Any plastic explosive that does not contain a detection agent in violation of 18 U... of this chapter for regulations on summary destruction of plastic explosives that do not contain a...

  16. 27 CFR 555.186 - Seizure or forfeiture.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Marking of Plastic Explosives § 555.186 Seizure or forfeiture. Any plastic explosive that does not contain a detection agent in violation of 18 U... of this chapter for regulations on summary destruction of plastic explosives that do not contain a...

  17. 27 CFR 555.186 - Seizure or forfeiture.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Marking of Plastic Explosives § 555.186 Seizure or forfeiture. Any plastic explosive that does not contain a detection agent in violation of 18 U... of this chapter for regulations on summary destruction of plastic explosives that do not contain a...

  18. 27 CFR 555.181 - Reporting of plastic explosives.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2011-04-01 2010-04-01 true Reporting of plastic..., FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Marking of Plastic Explosives § 555.181 Reporting of plastic explosives. All persons, other than an agency of the United States...

  19. 27 CFR 555.181 - Reporting of plastic explosives.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Reporting of plastic..., FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Marking of Plastic Explosives § 555.181 Reporting of plastic explosives. All persons, other than an agency of the United States...

  20. 27 CFR 555.181 - Reporting of plastic explosives.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2013-04-01 2013-04-01 false Reporting of plastic..., FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Marking of Plastic Explosives § 555.181 Reporting of plastic explosives. All persons, other than an agency of the United States...

  1. 27 CFR 555.181 - Reporting of plastic explosives.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2014-04-01 2014-04-01 false Reporting of plastic..., FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Marking of Plastic Explosives § 555.181 Reporting of plastic explosives. All persons, other than an agency of the United States...

  2. 27 CFR 555.181 - Reporting of plastic explosives.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2012-04-01 2010-04-01 true Reporting of plastic..., FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Marking of Plastic Explosives § 555.181 Reporting of plastic explosives. All persons, other than an agency of the United States...

  3. Depth Discrimination Using Rg-to-Sg Spectral Amplitude Ratios for Seismic Events in Utah Recorded at Local Distances

    DOE PAGES

    Tibi, Rigobert; Koper, Keith D.; Pankow, Kristine L.; ...

    2018-03-20

    Most of the commonly used seismic discrimination approaches are designed for regional data. Relatively little attention has focused on discriminants for local distances (< 200 km), the range at which the smallest events are recorded. We take advantage of the variety of seismic sources and the existence of a dense regional seismic network in the Utah region to evaluate amplitude ratio seismic discrimination at local distances. First, we explored phase-amplitude Pg-to-Sg ratios for multiple frequency bands to classify events in a dataset that comprises populations of single-shot surface explosions, shallow and deep ripple-fired mining blasts, mining-induced events, and tectonic earthquakes.more » We achieved a limited success. Then, for the same dataset, we combined the Pg-to-Sg phase-amplitude ratios with Sg-to-Rg spectral amplitude ratios in a multivariate quadratic discriminant function (QDF) approach. For two-category, pairwise classification, seven out of ten population pairs show misclassification rates of about 20% or less, with five pairs showing rates of about 10% or less. The approach performs best for the pair involving the populations of single-shot explosions and mining-induced events. By combining both Pg-to-Sg and Rg-to-Sg ratios in the multivariate QDFs, we are able to achieve an average improvement of about 4–14% in misclassification rates compared to Pg-to-Sg ratios alone. When all five event populations are considered simultaneously, as expected, the potential for misclassification increases and our QDF approach using both Pg-to-Sg and Rg-to-Sg ratios achieves an average success rate of about 74%, compared to the rate of about 86% for two-category, pairwise classification.« less

  4. Partitioning of pyroclasts between ballistic transport and a convective plume: Kīlauea volcano, 19 March 2008

    NASA Astrophysics Data System (ADS)

    Houghton, B. F.; Swanson, D. A.; Biass, S.; Fagents, S. A.; Orr, T. R.

    2017-05-01

    We describe the discrete ballistic and wind-advected products of a small, but exceptionally well-characterized, explosive eruption of wall-rock-derived pyroclasts from Kīlauea volcano on 19 March 2008 and, for the first time, integrate the size distribution of the two subpopulations to reconstruct the true size distribution of a population of pyroclasts as it exited from the vent. Based on thinning and fining relationships, the wind-advected fraction had a mass of 6.1 × 105 kg and a thickness half distance of 110 m, placing it at the bottom end of the magnitude and intensity spectra of pyroclastic falls. The ballistic population was mapped, in the field and by using structure-from-motion techniques, to a diameter of > 10-20 cm over an area of 0.1 km2, with an estimated mass of 1 × 105 kg. Initial ejection velocities of 50-80 m/s were estimated from inversion of isopleths. The total grain size distribution was estimated by using a mass partitioning of 98% of wind-advected material and 2% of ballistics, resulting in median and sorting values of -1.7ϕ and 3.1ϕ. It is markedly broader than those calculated for the products of magmatic explosive eruptions, because the grain size of 19 March 2008 clast population is unrelated to a volcanic fragmentation event and instead was "inherited" from a population of talus clasts that temporary blocked the vent prior to the eruption. Despite a conspicuous near-field presence, the ballistic subpopulation has only a minor influence on the grain size distribution because of its rapid thinning and fining away from source.

  5. Depth Discrimination Using Rg-to-Sg Spectral Amplitude Ratios for Seismic Events in Utah Recorded at Local Distances

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tibi, Rigobert; Koper, Keith D.; Pankow, Kristine L.

    Most of the commonly used seismic discrimination approaches are designed for regional data. Relatively little attention has focused on discriminants for local distances (< 200 km), the range at which the smallest events are recorded. We take advantage of the variety of seismic sources and the existence of a dense regional seismic network in the Utah region to evaluate amplitude ratio seismic discrimination at local distances. First, we explored phase-amplitude Pg-to-Sg ratios for multiple frequency bands to classify events in a dataset that comprises populations of single-shot surface explosions, shallow and deep ripple-fired mining blasts, mining-induced events, and tectonic earthquakes.more » We achieved a limited success. Then, for the same dataset, we combined the Pg-to-Sg phase-amplitude ratios with Sg-to-Rg spectral amplitude ratios in a multivariate quadratic discriminant function (QDF) approach. For two-category, pairwise classification, seven out of ten population pairs show misclassification rates of about 20% or less, with five pairs showing rates of about 10% or less. The approach performs best for the pair involving the populations of single-shot explosions and mining-induced events. By combining both Pg-to-Sg and Rg-to-Sg ratios in the multivariate QDFs, we are able to achieve an average improvement of about 4–14% in misclassification rates compared to Pg-to-Sg ratios alone. When all five event populations are considered simultaneously, as expected, the potential for misclassification increases and our QDF approach using both Pg-to-Sg and Rg-to-Sg ratios achieves an average success rate of about 74%, compared to the rate of about 86% for two-category, pairwise classification.« less

  6. Effect of type of explosives and physical-mechanical properties of explosive rock on formation of toxic gases in atmosphere of shafts

    NASA Technical Reports Server (NTRS)

    Mindeli, E. O.; Khudyakov, M. Y.

    1981-01-01

    The quality of toxic gases formed during explosive work in underground shafts depends upon the type of explosives and the conditions of explosion. Several types of explosives and rocks were examined. All remaining conditions were maintained the same (sandy-argillaceous stemming, electrical method of explosions, diameter of blast holes, and the direct triggering of charges).

  7. Air pollution: a smoking gun for cancer

    PubMed Central

    Zhang, Wei; Qian, Chao-Nan; Zeng, Yi-Xin

    2014-01-01

    Once considered a taboo topic or stigma, cancer is the number one public health enemy in the world. Once a product of an almost untouchable industry, tobacco is indisputably recognized as a major cause of cancer and a target for anticancer efforts. With the emergence of new economic powers in the world, especially in highly populated countries such as China, air pollution has rapidly emerged as a smoking gun for cancer and has become a hot topic for public health debate because of the complex political, economic, scientific, and technologic issues surrounding the air pollution problem. This editorial and the referred articles published in this special issue of the Chinese Journal of Cancer discuss these fundamental questions. Does air pollution cause a wide spectrum of cancers? Should air pollution be considered a necessary evil accompanying economic transformation in developing countries? Is an explosion of cancer incidence coming to China and how soon will it arrive? What must be done to prevent this possible human catastrophe? Finally, the approaches for air pollution control are also discussed. PMID:24636233

  8. The role of selective predation in harmful algal blooms

    NASA Astrophysics Data System (ADS)

    Solé, Jordi; Garcia-Ladona, Emilio; Estrada, Marta

    2006-08-01

    A feature of marine plankton communities is the occurrence of rapid population explosions. When the blooming species are directly or indirectly noxious for humans, these proliferations are denoted as harmful algal blooms (HAB). The importance of biological interactions for the appearance of HABs, in particular when the proliferating microalgae produce toxins that affect other organisms in the food web, remains still poorly understood. Here we analyse the role of toxins produced by a microalgal species and affecting its predators, in determining the success of that species as a bloom former. A three-species predator-prey model is used to define a criterion that determines whether a toxic microalga will be able to initiate a bloom in competition against a non-toxic one with higher growth rate. Dominance of the toxic species depends on a critical parameter that defines the degree of feeding selectivity by grazers. The criterion is applied to a particular simplified model and to numerical simulations of a full marine ecosystem model. The results suggest that the release of toxic compounds affecting predators may be a plausible biological factor in allowing the development of HABs.

  9. Numerical Simulation on Smoke Spread and Temperature Distribution in a Corn Starch Explosion

    NASA Astrophysics Data System (ADS)

    Lin, CherngShing; Hsu, JuiPei

    2018-01-01

    It is discovered from dust explosion accidents in recent years that deep causes of the accidents lies in insufficient cognition of dust explosion danger, and no understanding on danger and information of the dust explosion. In the study, Fire Dynamics Simulator (FDS) evaluation tool is used aiming at Taiwan Formosa Fun Coast explosion accidents. The calculator is used for rebuilding the explosion situation. The factors affecting casualties under explosion are studied. The injured personnel participating in the party are evaluated according to smoke diffusion and temperature distribution for numerical simulation results. Some problems noted in the fire disaster after actual explosion are proposed, rational site analysis is given, thereby reducing dust explosion risk grade.

  10. Non-detonable explosive simulators

    DOEpatents

    Simpson, Randall L.; Pruneda, Cesar O.

    1994-01-01

    A simulator which is chemically equivalent to an explosive, but is not detonable. The simulator has particular use in the training of explosives detecting dogs and calibrating sensitive analytical instruments. The explosive simulants may be fabricated by different techniques, a first involves the use of standard slurry coatings to produce a material with a very high binder to explosive ratio without masking the explosive vapor, and the second involves coating inert beads with thin layers of explosive molecules.

  11. 32 CFR 644.531 - Warning to public of danger in handling explosive missiles.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... explosive missiles. 644.531 Section 644.531 National Defense Department of Defense (Continued) DEPARTMENT OF... handling explosive missiles. When any land which has been contaminated with explosive objects, or chemical..., in the event of the discovery of an explosive missile, or an object resembling an explosive missile...

  12. 32 CFR 644.531 - Warning to public of danger in handling explosive missiles.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... explosive missiles. 644.531 Section 644.531 National Defense Department of Defense (Continued) DEPARTMENT OF... handling explosive missiles. When any land which has been contaminated with explosive objects, or chemical..., in the event of the discovery of an explosive missile, or an object resembling an explosive missile...

  13. 29 CFR 1926.905 - Loading of explosives or blasting agents.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 8 2010-07-01 2010-07-01 false Loading of explosives or blasting agents. 1926.905 Section... Explosives § 1926.905 Loading of explosives or blasting agents. (a) Procedures that permit safe and efficient... have contained explosives or blasting agents. (g) No explosives or blasting agents shall be left...

  14. Prediction of the explosion effect of aluminized explosives

    NASA Astrophysics Data System (ADS)

    Zhang, Qi; Xiang, Cong; Liang, HuiMin

    2013-05-01

    We present an approach to predict the explosion load for aluminized explosives using a numerical calculation. A code to calculate the species of detonation products of high energy ingredients and those of the secondary reaction of aluminum and the detonation products, velocity of detonation, pressure, temperature and JWL parameters of aluminized explosives has been developed in this study. Through numerical calculations carried out with this code, the predicted JWL parameters for aluminized explosives have been compared with those measured by the cylinder test. The predicted JWL parameters with this code agree with those measured by the cylinder test. Furthermore, the load of explosion for the aluminized explosive was calculated using the numerical simulation by using the JWL equation of state. The loads of explosion for the aluminized explosive obtained using the predicted JWL parameters have been compared with those using the measured JWL parameters. Both of them are almost the same. The numerical results using the predicted JWL parameters show that the explosion air shock wave is the strongest when the mass fraction of aluminum powder in the explosive mixtures is 30%. This result agrees with the empirical data.

  15. Effectiveness of quality-control aids in verifying K-9-team explosive detection performance

    NASA Astrophysics Data System (ADS)

    Hallowell, Susan F.; Fischer, Douglas S.; Brasher, Jeffrey D.; Malone, Robert L.; Gresham, Garold L.; Rae, Cathy

    1997-02-01

    The Federal Aviation Administration (FAA) and supporting agencies conducted a developmental test and evaluation (DTE) to determine if quality control aids (QCAs) could be developed that would provide effective surrogates to actual explosives used for training and testing K-9 explosives detection teams. Non-detonable surrogates are required to alleviate logistics and contamination issues with explosives used sa training aids. Comparative K-9 team detection performance for explosives used as training aids and QCAs configurations of each explosive type were evaluated to determine the optimal configuration for the QCA configuration of each explosive type were evaluated to determine the optimal configuration for the QCAs. The configurations were a paper patch impregnated with a solution of the explosive, a cloth pouch filed with small amounts of solid explosive, and the non-hazardous explosive for security training and testing material. The DTE was conducted at Lackland Air Force Base in San Antonio, Texas, where the K-9 teams undergo initial training. Six FAA certified operational teams participated. All explosives and QCAs were presented to the K-9 teams using a 10 scent box protocol. The results show that K-9 team as are more sensitive to explosives than the candidate QCAs. More importantly, it was discovered that the explosives at Lackland AFB are cross-contaminated, meaning that explosives possessed volatile artifacts from other explosives. There are two potential hypotheses explaining why the dogs did not detect the QCAs. First, the cross-contamination of Lackland training explosives may mean that K-9 teams are only trained to detect the explosives with the most volatile chemical signatures. Alternatively, the QCA configurations may have been below the trained detection threshold of the K-9s. It is recommended that K-9 teams train on uncontaminated odors from properly designed QCAs to ensure that dogs respond to the appropriate explosive components, and not some other constituent or contaminant.

  16. Research: the third dimension of librarianship.

    PubMed Central

    Love, E

    1980-01-01

    The rapid accumulation of data through increasingly sophisticated computer technology has created an unprecedented information explosion which might better be called an ignorance explosion. Data gathering emphasizing quantity rather than quality, speed of transmission rather than reliability or relevance, poses a challenge to the future of librarianship. Two concerns are discussed: (1) Relationship of technology to the information age. Librarians must be concerned with the methodology used in data collection, including the value judgments reflected in this activity. (2) Preparation of medical librarianship for the future. The profession will grow only as a result of individual effort, the recognition of people, and an appreciation of human values. Thus far, attempts to evaluate needs focus on technology while neglecting research into the human aspect. The author proposes that dimensions of the total professional model for medical librarianship must include research, as well as education and practice. The need to aid in the development of library researchers at the Ph.D. level through a National Library of Medicine program similar to that offered to researchers by the National Institutes of Health is stressed. By way of federal assistance and scholarships made available through national library associations, library research can become the vital and effective third dimension that will redefine the traditional concept of information storage and service in human terms, thus introducing a new relevance into the area of medical librarianship during the coming decades. PMID:7356492

  17. Optically detonated explosive device

    NASA Technical Reports Server (NTRS)

    Yang, L. C.; Menichelli, V. J. (Inventor)

    1974-01-01

    A technique and apparatus for optically detonating insensitive high explosives, is disclosed. An explosive device is formed by containing high explosive material in a house having a transparent window. A thin metallic film is provided on the interior surface of the window and maintained in contact with the high explosive. A laser pulse provided by a Q-switched laser is focussed on the window to vaporize the metallic film and thereby create a shock wave which detonates the high explosive. Explosive devices may be concurrently or sequentially detonated by employing a fiber optic bundle to transmit the laser pulse to each of the several individual explosive devices.

  18. Method for fabricating non-detonable explosive simulants

    DOEpatents

    Simpson, Randall L.; Pruneda, Cesar O.

    1995-01-01

    A simulator which is chemically equivalent to an explosive, but is not detonable. The simulator has particular use in the training of explosives detecting dogs and calibrating sensitive analytical instruments. The explosive simulants may be fabricated by different techniques, a first involves the use of standard slurry coatings to produce a material with a very high binder to explosive ratio without masking the explosive vapor, and the second involves coating inert beads with thin layers of explosive molecules.

  19. Non-detonable explosive simulators

    DOEpatents

    Simpson, R.L.; Pruneda, C.O.

    1994-11-01

    A simulator which is chemically equivalent to an explosive, but is not detonable. The simulator has particular use in the training of explosives detecting dogs and calibrating sensitive analytical instruments. The explosive simulants may be fabricated by different techniques, a first involves the use of standard slurry coatings to produce a material with a very high binder to explosive ratio without masking the explosive vapor, and the second involves coating inert beads with thin layers of explosive molecules. 5 figs.

  20. KLEPSUDRA: How the Rio Grande Treaty Increased Instability in Mexico

    DTIC Science & Technology

    2008-05-09

    Projected changes in trade patterns, population growth, consumer preferences and climate change will require a reassessment of American policies towards...land (which increased by 44%) shifted towards water intensive crops to accommodate market demands in the United States, Canada and shifts in consumer ... preferences in Mexico.20 NAFTA triggered explosive growth in fruit and produce exports to the United States and represents a sizeable “virtual” water

  1. Textural evidence for high-grade ignimbrites formed by low-explosivity eruptions, Paraná Magmatic Province, southern Brazil

    NASA Astrophysics Data System (ADS)

    Luchetti, Ana Carolina F.; Gravley, Darren M.; Gualda, Guilherme A. R.; Nardy, Antonio J. R.

    2018-04-01

    The Paraná-Etendeka Province is a Lower Cretaceous huge bimodal tholeiitic volcanic province (1 million·km3) that predated the Gondwana breakup. Its silicic portion makes up a total volume of at least 20,000 km3 and in southern Brazil it comprises the Chapecó porphyritic high-Ti trachydacites-dacites and the Palmas microporphyritic-aphyric low-Ti dacites-rhyolites. The widespread silicic sheets are debated in the literature because they bear similarities between lavas and high grade ignimbrites. Here we provide new observations and interpretations for flow units with large, dark, and vesicle-poor lens-shaped blobs surrounded by a light-colored matrix. The textural features (macro- to micro-scale) of these blobs are different from typical pumice and/or fiamme and support a low explosivity pyroclastic origin, possibly low-column fountain eruptions with discharge rates high enough to produce laterally extensive high-grade ignimbrites. Such an interpretation, combined with a conspicuous absence of lithic fragments in the deposits, is aligned with a lack of identified calderas in the Paraná-Etendeka Province. Maximum timescales of crystallization associated with the juvenile blobs and estimated from CSD slopes are on the order of millennia for phenocryst populations and on the order of decades for microphenocryst populations.

  2. Host Galaxy Spectra of Stripped SN from the Palomar Transient Factory: SN Progenitor Diagnostics and the SN-GRB Connection

    NASA Astrophysics Data System (ADS)

    Modjaz, Maryam; Gal-Yam, Avishay; Arcavi, Iair

    2012-02-01

    Stripped core-collapse supernovae (Stripped SNe) are powerful cosmic engines that energize and enrich the ISM and that sometimes accompany GRBs, but the exact mass and metallicity range of their massive progenitors is not known, nor the detailed physics of the explosion. We propose to continue conducting the first uniform and statistically significant study of host galaxies of 60 stripped SNe from the same innovative, homogeneous and galaxy-unbiased survey Palomar Transient Factory in order to determine the environmental conditions that influence the various kinds of massive stellar deaths. By obtaining spectra of the immediate host environments of our sample of stripped SN, we will (1) measure local abundances in order to differentiate between the two progenitor scenarios for stripped SN and (2) derive stellar population ages, masses and star formation histories via detailed stellar population synthesis models. Moreover, we will test if natal chemical abundance has effects on basic SN characteristics, such as peak luminosity. Any observed trends will have ramifications on SN and GRB explosion models and imply important demographic SN considerations. Our dataset will provide a crucial complimentary set to host galaxy studies of long-duration GRBs and pave the way for host studies of transients and SN found via upcoming surveys such as LSST.

  3. Host Galaxy Spectra of Stripped SN from the Palomar Transient Factory: SN Progenitor Diagnostics and the SN-GRB Connection

    NASA Astrophysics Data System (ADS)

    Modjaz, Maryam; Gal-Yam, Avishay; Arcavi, Iair

    2011-02-01

    Stripped core-collapse supernovae (Stripped SN) are powerful cosmic engines that energize and enrich the ISM and that sometimes accompany GRBs, but the exact mass and metallicity range of their massive progenitors is not known, nor the detailed physics of the explosion. With the harvest of 50 stripped SN from the innovative survey Palomar Transient Factory, we propose to conduct the first uniform and statistically significant study with SN from the same homogeneous and galaxy-unbiased survey in order to determine the environmental conditions that influence the various kinds of massive stellar deaths. By obtaining spectra of the immediate host environments of our sample of stripped SN, we will (1) measure local abundances in order to differentiate between the two progenitor scenarios for stripped SN and (2) derive stellar population ages, masses and star formation histories via detailed stellar population synthesis models. Moreover, we will test if natal chemical abundance has effects on basic SN characteristics, such as peak luminosity. Any observed trends will have ramifications on SN and GRB explosion models and imply important demographic SN considerations. Our dataset will provide a crucial complimentary set to host galaxy studies of long-duration GRBs and pave the way for host studies of transients and SN found via upcoming surveys such as LSST.

  4. The 16 August 1997 Novaya Zemlya seismic event as viewed from GSN stations KEV and KBS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hartse, H.E.

    1997-11-01

    Using current and historic seismic records from Global Seismic Network stations KEV and KBS, the authors find that S minus P arrival time comparisons between nuclear explosions and the 16 August 1997 seismic event (m{sub b} {approx} 3.6) from near Novaya Zemlya clearly indicate that (relative to KEV) the 16 August event occurred at least 80 km east of the Russian test site. Including S minus P arrival times from KBS constrains the location to beneath the Kara Sea and in good agreement with previously reported locations, over 100 km southeast of the test site. From an analysis of P{submore » n}/S{sub n} waveform ratios at frequencies above 4 Hz, they find that the 16 August event falls within the population of regional earthquakes and is distinctly separated from Novaya Zemlya and other northern Eurasian nuclear explosion populations. Thus, given its location and waveform characteristics, they conclude the 16 August event was an earthquake. The 16 August event was not detected at teleseismic distances, and thus, this event provides a good example of the regional detection, location, and identification efforts that will be required to monitor the Comprehensive Test Ban Treaty below m{sub b} {approx} 4.« less

  5. Electronic properties of RDX and HMX: Compton scattering experiment and first-principles calculation.

    PubMed

    Ahuja, B L; Jain, Pradeep; Sahariya, Jagrati; Heda, N L; Soni, Pramod

    2013-07-11

    The first-ever electron momentum density (EMD) measurements of explosive materials, namely, RDX (1,3,5-trinitro-1,3,5-triazacyclohexane, (CH2-N-NO2)3) and HMX (1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane, (CH2-N-NO2)4), have been reported using a 740 GBq (137)Cs Compton spectrometer. Experimental Compton profiles (CPs) are compared with the EMDs derived from linear combination of atomic orbitals with density functional theory. It is found that the CPs deduced from generalized gradient approximation (GGA) with Wu-Cohen exchange energies give a better agreement with the corresponding experimental profiles than those from local density approximation and other schemes of GGA. Further, Mulliken population, energy bands, partial and total density of states, and band gap have also been reported using GGA calculations. Present ground state calculations unambiguously show large band gap semiconductor nature of both RDX and HMX. A similar type of bonding in these materials is uniquely established using Compton data and density of states. It is also outstandingly consistent with the Mulliken population, which predicts almost equal amount of charge transfer (0.84 and 0.83 e(-)) from H1 + H2 + N2 to C1 + N1 + O1 + O2 in both the explosives.

  6. Controls on Explosive Eruptions along the Pacific-Antarctic Ridge

    NASA Astrophysics Data System (ADS)

    Lewis, M.; Asimow, P. D.; Lund, D. C.

    2016-12-01

    Sediment core OC170-26-159 was retrieved at 38.967°S, 111.35°W, a location that was 8-9km away from the Pacific-Antarctic Ridge (PAR) axis at the time of Glacial Termination II (T-II), 130ka, a period characterized by enhanced flux of hydrothermal metals to the near-ridge sediments on the East Pacific Rise (Lund et. al. 2016). An interval of enhanced Ti content in OC170-26-159 during T-II is rich in basaltic glass shards that we interpret to be the products of explosive submarine volcanic eruptions. Explosive eruptions of this scale are rare at mid-ocean ridges, so we studied the glass to evaluate whether sea level driven modulation in magmatic flux might be related to the frequency of such events though emplacement of distinct compositions or volatile contents. We report major element and volatile content data for the basaltic glasses and compare the results to literature data (PetDB) from on-axis sampling of the nearest ridge segment, to assess whether the glass was derived from the ridge axis and if it is unusual compared to the axial samples. Major element compositional data show that the glasses are a nearly homogenous population (MgO 5.8 to 6.5%). The heterogeneity is similar to that in single flows in Iceland (Maclennan et. al. 2003) and Hawaii (Garcia et. al. 2000), but the shards are dispersed across a gradient in δ18O, suggesting a closely spaced series of similar eruptions. The glasses are more evolved than any effusively erupted basalts on the PAR, yet are consistent with the same liquid line of descent, linking the explosive products to the axial magmatic system. The MELTS thermodynamic model allows us to calculate the changes in multiple variables along the liquid line of descent between the axial and explosive liquid compositions. Comparison of H2O and CO2 contents to those from axial flows will constrain whether variations in these components are related to eruption styles. These results will constrain the connection between sea level driven variations in magma supply rate, hydrothermal activity, thermal state of the axial magma chamber, volatile exsolution, and the potential for explosive submarine eruptions.

  7. Return on Investment (ROI) Framework Case Study: CTH.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Corro, Janna L.

    CTH is a Eulerian code developed at Sandia National Laboratories capable of modeling the hydrodynamic response of explosives, liquids, gases, and solids. The code solves complex multi-dimensional problems characterized by large deformations and strong shocks that are composed of various material configurations. CTH includes models for material strength, fracture, porosity, and high explosive detonation and initiation. The code is an acronym for a complex series of names relating to its origin. A full explanation can be seen in Appendix A. The software breaks penetration simulations into millions of grid-like “cells”. As a modeled projectile impacts and penetrates a target, progressivelymore » smaller blocks of cells are placed around the projectile, which show in detail deformations and breakups. Additionally, the code is uniquely suited to modeling blunt impact and blast loading leading to human body injury.« less

  8. Ammonium nitrate explosive systems

    DOEpatents

    Stinecipher, Mary M.; Coburn, Michael D.

    1981-01-01

    Novel explosives which comprise mixtures of ammonium nitrate and an ammonium salt of a nitroazole in desired ratios are disclosed. A preferred nitroazole is 3,5-dinitro-1,2,4-triazole. The explosive and physical properties of these explosives may readily be varied by the addition of other explosives and oxidizers. Certain of these mixtures have been found to act as ideal explosives.

  9. Effects of lunar phases on short-term, explosive physical performance among young trained athletes.

    PubMed

    Yousfi, Narimen; Mejri, Mohamed Arbi; Rouissi, Mehdi; Hammami, Amri; Tabben, Montassar; Chaouachi, Anis; Haddad, Monoem; Chamari, Karim

    2018-04-01

    Beliefs that lunar phases affect human physiology started in ancient times. Research has recently revealed that a physical fitness index increased in sedentary students at the new moon (NM) and full moon (FM) compared to other moon phases. However, the effect of lunar cycle (moon illumination and gravitational pull) on physical performance in athletes was not examined. Therefore, this study aimed to evaluate whether short-term explosive performance can be influenced by the different phases of the lunar cycle. Fourteen young male Taekwondo athletes (age: 16.9 ± 0.7 years, height: 159.7 ± 50.6 cm, body mass: 62.85 ± 7.84 kg) performed the following tests to assess the explosive physical performance during the different phases of the lunar cycle (NM, FQ (first quarter), FM, and LQ (last quarter)): maximal isometric manual contraction (dominant hand (MIMCD) and non-dominant hand (MIMCND)), maximal back isometric contraction (MBIC), squat jump (SJ), countermovement jump (CMJ), and 10-m sprint (10 m). The testing sessions during the different moon phases were performed in a counterbalanced order. The order of tests remained the same (MIMCD, MIMCND, MBIC, SJ, CMJ, and 10 m), and all sessions were performed in the evening (6:00 to 8:00 p.m.) on the first day of each evaluated lunar phase. Each parameter was measured over two consecutive lunar months in the calendar. Analysis of variance tests showed that there was no significant effect of lunar cycle on all explosive test measures, p > 0.05. Our results failed to identify any effect of lunar phase on evening explosive performance (mainly involving phosphagen pathway-based efforts) among young trained athletes. Therefore, it appears that moon phase/illumination does not affect short-term physical performance in young trained adolescents.

  10. Seismic Analysis of Three Bomb Explosions in Turkey

    NASA Astrophysics Data System (ADS)

    Necmioglu, O.; Semin, K. U.; Kocak, S.; Destici, C.; Teoman, U.; Ozel, N. M.

    2016-12-01

    Seismic analysis of three vehicle-installed bomb explosions occurred on 13 March 2016 in Ankara, 12 May 2016 in Diyarbakır and 9 July 2016 in Mardin have been conducted using data from the nearest stations (LOD, DYBB and MAZI) of the Boğaziçi University - Kandilli Observatory and Earthquake Research Institute's (KOERI) seismic network and compared with low-magnitude earthquakes in similar distance based on phase readings and frequency content. Amplitude spectra has been compared through Fourier transformation and earthquake-explosion frequency discrimination has been performed using various filter bands. Time-domain and spectral analysis have been performed using Geotool software provided by CTBTO. Local magnitude (ML) values have been calculated for each explosion by removing instrument-response and adding Wood-Anderson type instrument response. Approximate amount of explosives used in these explosions have been determined using empirical methods of Koper (2002). Preliminary results indicated that 16 tons TNT equivalent explosives have been used in 12 May 2016 Diyarbakır explosion, which is very much in accordance with the media reports claiming 15 tons of TNT. Our analysis for 9 July 2016 Mardin explosion matched the reported 5 tons of explosives. Results concerning 13 March 2016 Ankara explosion indicated that approximately 1,7 ton of TNT equivalent explosives were used in the attack whereas security and intelligence reports claimed 300 kg explosives as a combination of TNT, RDX and ammonium nitrate. The overestimated results obtained in our analysis for the Ankara explosion may be related due to i) high relative effectiveness factor of the RDX component of the explosive ii) inefficiency of Koper (2002) method in lower yields (since the method was developed using explosions with yields of 3-12 tons of TNT), iii) combination of both.

  11. 49 CFR 172.411 - EXPLOSIVE 1.1, 1.2, 1.3, 1.4, 1.5 and 1.6 labels, and EXPLOSIVE Subsidiary label.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false EXPLOSIVE 1.1, 1.2, 1.3, 1.4, 1.5 and 1.6 labels..., 1.2, 1.3, 1.4, 1.5 and 1.6 labels, and EXPLOSIVE Subsidiary label. (a) Except for size and color....5 and EXPLOSIVE 1.6 labels must be as follows: EXPLOSIVE 1.4: EC02MR91.016 EXPLOSIVE 1.5: EC02MR91...

  12. Insensitive fuze train for high explosives

    DOEpatents

    Cutting, Jack L.; Lee, Ronald S.; Von Holle, William G.

    1994-01-01

    A generic insensitive fuze train to initiate insensitive high explosives, such as PBXW-124. The insensitive fuze train uses a slapper foil to initiate sub-gram quantities of an explosive, such as HNS-IV or PETN. This small amount of explosive drives a larger metal slapper onto a booster charge of an insensitive explosive, such as UF-TATB. The booster charge initiates a larger charge of an explosive, such as LX-17, which in turn, initiates the insensitive high explosive, such as PBXW-124.

  13. Method for fabricating non-detonable explosive simulants

    DOEpatents

    Simpson, R.L.; Pruneda, C.O.

    1995-05-09

    A simulator is disclosed which is chemically equivalent to an explosive, but is not detonable. The simulator has particular use in the training of explosives detecting dogs and calibrating sensitive analytical instruments. The explosive simulants may be fabricated by different techniques, a first involves the use of standard slurry coatings to produce a material with a very high binder to explosive ratio without masking the explosive vapor, and the second involves coating inert beads with thin layers of explosive molecules. 5 figs.

  14. Insensitive fuze train for high explosives

    DOEpatents

    Cutting, J.L.; Lee, R.S.; Von Holle, W.G.

    1994-01-04

    A generic insensitive fuze train to initiate insensitive high explosives, such as PBXW-124 is described. The insensitive fuze train uses a slapper foil to initiate sub-gram quantities of an explosive, such as HNS-IV or PETN. This small amount of explosive drives a larger metal slapper onto a booster charge of an insensitive explosive, such as UF-TATB. The booster charge initiates a larger charge of an explosive, such as LX-17, which in turn, initiates the insensitive high explosive, such as PBXW-124. 3 figures.

  15. Invited Commentary: Cassel's "The Contribution of the Social Environment to Host Resistance"-A Modern Classic.

    PubMed

    James, Sherman A

    2017-06-01

    John Cassel's 1976 paper "The Contribution of the Social Environment to Host Resistance" (Am J Epidemiol. 1976;104(2):107-123) is widely regarded as a classic in epidemiology. He makes the compelling argument that the quality of a person's social relationships, that is, the degree to which her relationships are more stressful than supportive (or vice versa) influences her susceptibility to disease independent of genetic endowment, diet, physical activity, etc. Cassel's provocative thesis was anchored in a cogent synthesis of findings from animal experiments and observational studies on diverse human populations. Beginning in the late 1970s, the paper stimulated an explosion of epidemiologic research on social support and human health. Beyond advancing epidemiologic theory, Cassel showed how findings from various epidemiologic study designs could be marshalled to build a persuasive causal argument that impaired social bonds increase the risk of premature disease and death. The paper also foreshadowed core ideas of later theoretical constructs, such as weathering and allostatic load, regarding the power of chronic environmental stressors to accelerate biological aging across multiple organ systems. Cassel's assessment of the research and practice implications of his conclusions has remarkable contemporary resonance for the field of epidemiology. © The Author 2017. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  16. Saving Coalition Lives and Limbs: Disrupting the Improvised Explosive Device Network in Iraq with Center of Gravity Analysis and Social Network Viral Targeting

    DTIC Science & Technology

    2008-12-21

    63, 73. 64. Evelin Gerda Lindner, ―In Times of In Times of Globalization and Human Rights: Does Humiliation Become the Most Disruptive Force...Force-Protection Issue, General Says.‖ American Forces Press Service, 14 February 2007. Lindner, Evelin Gerda . ―In Times of In Times of

  17. SEVESO WOMEN'S HEALTH STUDY: A STUDY OF THE EFFECTS OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN ON REPRODUCTIVE HEALTH. (R824761)

    EPA Science Inventory

    Abstract

    Although reproductive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure have been reported in numerous investigations of animals, studies of this association in humans are limited. In 1976, an explosion in Seveso, Italy exposed the surround...

  18. The wings of Daedalus: The convergence of myth and technology in 20th century culture

    NASA Technical Reports Server (NTRS)

    Kowitt, Mark E.; Kaplan, Michael S.

    1993-01-01

    In the second half of the 20th century, age-old human fantasies of leaving the Earth and touching the stars have been fulfilled by advances in space science and technology, whose roots are threaded through our history. Current advances are so explosive that the fundamental orientation of Western culture is being radically altered.

  19. Overcoming an obstacle in expanding a UMLS semantic type extent.

    PubMed

    Chen, Yan; Gu, Huanying; Perl, Yehoshua; Geller, James

    2012-02-01

    This paper strives to overcome a major problem encountered by a previous expansion methodology for discovering concepts highly likely to be missing a specific semantic type assignment in the UMLS. This methodology is the basis for an algorithm that presents the discovered concepts to a human auditor for review and possible correction. We analyzed the problem of the previous expansion methodology and discovered that it was due to an obstacle constituted by one or more concepts assigned the UMLS Semantic Network semantic type Classification. A new methodology was designed that bypasses such an obstacle without a combinatorial explosion in the number of concepts presented to the human auditor for review. The new expansion methodology with obstacle avoidance was tested with the semantic type Experimental Model of Disease and found over 500 concepts missed by the previous methodology that are in need of this semantic type assignment. Furthermore, other semantic types suffering from the same major problem were discovered, indicating that the methodology is of more general applicability. The algorithmic discovery of concepts that are likely missing a semantic type assignment is possible even in the face of obstacles, without an explosion in the number of processed concepts. Copyright © 2011 Elsevier Inc. All rights reserved.

  20. Overcoming an Obstacle in Expanding a UMLS Semantic Type Extent

    PubMed Central

    Chen, Yan; Gu, Huanying; Perl, Yehoshua; Geller, James

    2011-01-01

    This paper strives to overcome a major problem encountered by a previous expansion methodology for discovering concepts highly likely to be missing a specific semantic type assignment in the UMLS. This methodology is the basis for an algorithm that presents the discovered concepts to a human auditor for review and possible correction. We analyzed the problem of the previous expansion methodology and discovered that it was due to an obstacle constituted by one or more concepts assigned the UMLS Semantic Network semantic type Classification. A new methodology was designed that bypasses such an obstacle without a combinatorial explosion in the number of concepts presented to the human auditor for review. The new expansion methodology with obstacle avoidance was tested with the semantic type Experimental Model of Disease and found over 500 concepts missed by the previous methodology that are in need of this semantic type assignment. Furthermore, other semantic types suffering from the same major problem were discovered, indicating that the methodology is of more general applicability. The algorithmic discovery of concepts that are likely missing a semantic type assignment is possible even in the face of obstacles, without an explosion in the number of processed concepts. PMID:21925287

  1. Spatial Rule-Based Modeling: A Method and Its Application to the Human Mitotic Kinetochore

    PubMed Central

    Ibrahim, Bashar; Henze, Richard; Gruenert, Gerd; Egbert, Matthew; Huwald, Jan; Dittrich, Peter

    2013-01-01

    A common problem in the analysis of biological systems is the combinatorial explosion that emerges from the complexity of multi-protein assemblies. Conventional formalisms, like differential equations, Boolean networks and Bayesian networks, are unsuitable for dealing with the combinatorial explosion, because they are designed for a restricted state space with fixed dimensionality. To overcome this problem, the rule-based modeling language, BioNetGen, and the spatial extension, SRSim, have been developed. Here, we describe how to apply rule-based modeling to integrate experimental data from different sources into a single spatial simulation model and how to analyze the output of that model. The starting point for this approach can be a combination of molecular interaction data, reaction network data, proximities, binding and diffusion kinetics and molecular geometries at different levels of detail. We describe the technique and then use it to construct a model of the human mitotic inner and outer kinetochore, including the spindle assembly checkpoint signaling pathway. This allows us to demonstrate the utility of the procedure, show how a novel perspective for understanding such complex systems becomes accessible and elaborate on challenges that arise in the formulation, simulation and analysis of spatial rule-based models. PMID:24709796

  2. High resolution 3D confocal microscope imaging of volcanic ash particles.

    PubMed

    Wertheim, David; Gillmore, Gavin; Gill, Ian; Petford, Nick

    2017-07-15

    We present initial results from a novel high resolution confocal microscopy study of the 3D surface structure of volcanic ash particles from two recent explosive basaltic eruptions, Eyjafjallajökull (2010) and Grimsvötn (2011), in Iceland. The majority of particles imaged are less than 100μm in size and include PM 10 s, known to be harmful to humans if inhaled. Previous studies have mainly used 2D microscopy to examine volcanic particles. The aim of this study was to test the potential of 3D laser scanning confocal microscopy as a reliable analysis tool for these materials and if so to what degree high resolution surface and volume data could be obtained that would further aid in their classification. First results obtained using an Olympus LEXT scanning confocal microscope with a ×50 and ×100 objective lens are highly encouraging. They reveal a range of discrete particle types characterised by sharp or concave edges consistent with explosive formation and sudden rupture of magma. Initial surface area/volume ratios are given that may prove useful in subsequent modelling of damage to aircraft engines and human tissue where inhalation has occurred. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. Totally confined explosive welding. [apparatus to reduce noise level and protect personnel during explosive bonding

    NASA Technical Reports Server (NTRS)

    Bement, L. J. (Inventor)

    1974-01-01

    A method and associated apparatus for confining the undesirable by-products and limiting noise of explosive welding are discussed. The apparatus consists fo a simple enclosure into which the explosive is placed and within which the explosion occurs. The shape of the enclosure, the placement of the explosive, and the manner in which the enclosure is placed upon the material to be welded determine the force of the explosion transmitted to the proposed bond area. The explosion is totally confined within the enclosure thus reducing the noise level and preventing debris from being strewn about to contaminate the weld area or create personnel hazards.

  4. Prospects for infrasound bolide detections from balloon-borne platforms

    NASA Astrophysics Data System (ADS)

    Young, Eliot; Bowman, Daniel; Arrowsmith, Stephen; Boslough, Marc; Klein, Viliam; Ballard, Courtney; Lees, Jonathan

    2017-04-01

    We report on an experiment to assess whether balloon-borne instruments can improve sensitivities to bolides exploding in the Earth's atmosphere (essentially using the atmosphere as a witness plate to characterize the small end of the NEO (Near Earth Object) population). The CTBTO's infrasound network regularly detects infrasound disturbances caused by bolides, including the 15-FEB-2013 Chelybinsk impact. Balloon-borne infrasound sensors should have two important advantages over ground-based infrasound stations: there should be virtually no wind noise on a free-floating platform, and a sensor in the stratosphere should benefit from its location within the stratospheric duct. Balloon-borne sensors also have the disadvantage that the amplitude of infrasound waves will decrease as they ascend with altitude. To test the performance of balloon-borne sensors, we conducted an experiment on a NASA high altitude (35 km) balloon launched from Ft Sumner, NM on 28-SEP-2016. We were able to put two independent infrasound payloads on this flight. We arranged for three 3000-lb ANFO explosions to be detonated from Socorro, NM at 12:00, 14:00 and 16:29:59 MST. The first two explosions were detected from the NASA balloon, with the first explosion showing three separate waveforms arriving within a 25-s span. The peak-to-peak amplitude of the waveforms was about 0.06 Pa, and the cleanest microphone channel detected this waveform with an SNR greater than 20. A second balloon at 15 km altitude also detected the second explosion. We have signals from a dozen ground stations at various positions from Socorro to Ft Sumner. We will report on wave propagation models and how they compare with observations from the two balloons and the various ground-stations.

  5. Neutrino-Driven Explosions

    NASA Astrophysics Data System (ADS)

    Janka, Hans-Thomas

    The question why and how core-collapse supernovae (SNe) explode is one of the central and most long-standing riddles of stellar astrophysics. Solving this problem is crucial for deciphering the supernova (SN) phenomenon; for predicting its observable signals such as light curves and spectra, nucleosynthesis yields, neutrinos, and gravitational waves; for defining the role of SNe in the dynamical and chemo-dynamical evolution of galaxies; and for explaining the birth conditions and properties of neutron stars (NSs) and stellar-mass black holes. Since the formation of such compact remnants releases over hundred times more energy in neutrinos than the kinetic energy of the SN explosion, neutrinos can be the decisive agents for powering the SN outburst. According to the standard paradigm of the neutrino-driven mechanism, the energy transfer by the intense neutrino flux to the medium behind the stagnating core bounce shock, assisted by violent hydrodynamic mass motions (sometimes subsumed by the term "turbulence"), revives the outward shock motion and thus initiates the SN explosion. Because of the weak coupling of neutrinos in the region of this energy deposition, detailed, multidimensional hydrodynamic models including neutrino transport and a wide variety of physics are needed to assess the viability of the mechanism. Owing to advanced numerical codes and increasing supercomputer power, considerable progress has been achieved in our understanding of the physical processes that have to act in concert for the success of neutrino-driven explosions. First studies begin to reveal observational implications and avenues to test the theoretical picture by data from individual SNe and SN remnants but also from population-integrated observables. While models will be further refined, a real breakthrough is expected through the next galactic core-collapse SN, when neutrinos and gravitational waves can be used to probe the conditions deep inside the dying star.

  6. Development of mine explosion ground truth smart sensors

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Taylor, Steven R.; Harben, Phillip E.; Jarpe, Steve

    Accurate seismo-acoustic source location is one of the fundamental aspects of nuclear explosion monitoring. Critical to improved location is the compilation of ground truth data sets for which origin time and location are accurately known. Substantial effort by the National Laboratories and other seismic monitoring groups have been undertaken to acquire and develop ground truth catalogs that form the basis of location efforts (e.g. Sweeney, 1998; Bergmann et al., 2009; Waldhauser and Richards, 2004). In particular, more GT1 (Ground Truth 1 km) events are required to improve three-dimensional velocity models that are currently under development. Mine seismicity can form themore » basis of accurate ground truth datasets. Although the location of mining explosions can often be accurately determined using array methods (e.g. Harris, 1991) and from overhead observations (e.g. MacCarthy et al., 2008), accurate origin time estimation can be difficult. Occasionally, mine operators will share shot time, location, explosion size and even shot configuration, but this is rarely done, especially in foreign countries. Additionally, shot times provided by mine operators are often inaccurate. An inexpensive, ground truth event detector that could be mailed to a contact, placed in close proximity (< 5 km) to mining regions or earthquake aftershock regions that automatically transmits back ground-truth parameters, would greatly aid in development of ground truth datasets that could be used to improve nuclear explosion monitoring capabilities. We are developing an inexpensive, compact, lightweight smart sensor unit (or units) that could be used in the development of ground truth datasets for the purpose of improving nuclear explosion monitoring capabilities. The units must be easy to deploy, be able to operate autonomously for a significant period of time (> 6 months) and inexpensive enough to be discarded after useful operations have expired (although this may not be part of our business plan). Key parameters to be automatically determined are event origin time (within 0.1 sec), location (within 1 km) and size (within 0.3 magnitude units) without any human intervention. The key parameter ground truth information from explosions greater than magnitude 2.5 will be transmitted to a recording and transmitting site. Because we have identified a limited bandwidth, inexpensive two-way satellite communication (ORBCOMM), we have devised the concept of an accompanying Ground-Truth Processing Center that would enable calibration and ground-truth accuracy to improve over the duration of a deployment.« less

  7. 27 CFR 555.182 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... or modified explosive materials; (2) Training in explosives detection or development or testing of explosives detection equipment; or (3) Forensic science purposes; or (b) Was plastic explosive that, by April... 555.182 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES...

  8. 27 CFR 555.182 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... or modified explosive materials; (2) Training in explosives detection or development or testing of explosives detection equipment; or (3) Forensic science purposes; or (b) Was plastic explosive that, by April... 555.182 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES...

  9. Investigating Degassing in Felsic and Mafic Magmas by 3-D Imaging of Vesicle Pathways

    NASA Astrophysics Data System (ADS)

    Polacci, M.; Baker, D. R.; Piochi, M.; Mancini, L.

    2009-12-01

    Volatiles are the motor of volcanic eruptions. Studies of vesiculation in erupted products can provide information on how volatiles exsolve, grow and are lost from magmas as lava and tephra fragments bear the fingerprints of such processes in vesicle and crystal textures. We summarize here the results of a series of X-ray computed microtomographic experiments that were performed on about 70 volcanic specimens of mainly basaltic and trachytic compositions. A first sample suite comprises samples collected from explosive activity at persistently degassing basaltic volcanoes, namely Stromboli (Aeolian Islands), Etna (Eastern Sicily) and Ambrym (Vanuatu Islands); a second suite consists of pumice and scoria clasts from Plinian to Subplinian to Vulcanian eruptions that occurred in the Campi Flegrei caldera (Southern Italy). The tomographic images provide us with a complete 3-D view of our sampled material through which it is possible to reconstruct the geometry of the vesicle network and explore how gas was transported in the investigated magmas. We find that basaltic scoriae exhibit two types of vesicles: large (~ mm^3), coalescing vesicles with complex, convoluted shapes and small-to-intermediate sized (<~1x10^-3 mm^3), spherical to sub-spherical, poorly connected or isolated vesicles. The former vesicles were interpreted as percolation pathways for gas to flow non-explosively to the volcano crater and thought to sustain the persistent passive gas release that characterizes these volcanoes. The fact that such vesicles were found in products erupted from active basaltic volcanoes located in different tectonic settings and characterized by different explosivity strongly suggests that basaltic systems appear to follow a common degassing pathway. However, not all explosive basaltic rocks contain large, coalescing vesicles. Pumice clasts from the much more violent, dangerous and less frequent paroxysmal explosions at Stromboli do not have this type of vesicles, demonstrating that basaltic volcanoes develop different vesicle textures and therefore degassing dynamics with increasing explosive activity. Trachytic pumices from highly explosive eruptions display a much finer structure in comparison to scoriae having sub-spherical to slightly deformed large vesicles and a large population of small spherical vesicles (1x10^-3 - <1x10^-5 mm^3). These two vesicle textures were mainly ascribed to the rapid ascent of a supersaturated magma under closed-system degassing, in comparison to the open-system conditions of basaltic magmas. Large interconnected vesicles that form micro-cracks are, however, found in some denser pyroclasts from Campi Flegrei. This suggests that gas was percolating in the conduit system before the eruption and that open-system degassing may be an effective way through which gas is lost in a moderately violent manner at the crater surface in some explosive felsic eruptions. Ultimately this study reveals that 3-D imaging of volcanic rocks is an essential tool for investigating degassing conditions in erupted magmas.

  10. Yield Determination of Underground and Near Surface Explosions

    NASA Astrophysics Data System (ADS)

    Pasyanos, M.

    2015-12-01

    As seismic coverage of the earth's surface continues to improve, we are faced with signals from a wide variety of explosions from various sources ranging from oil train and ordnance explosions to military and terrorist attacks, as well as underground nuclear tests. We present on a method for determining the yield of underground and near surface explosions, which should be applicable for many of these. We first review the regional envelope method that was developed for underground explosions (Pasyanos et al., 2012) and more recently modified for near surface explosions (Pasyanos and Ford, 2015). The technique models the waveform envelope templates as a product of source, propagation (geometrical spreading and attenuation), and site terms, while near surface explosions include an additional surface effect. Yields and depths are determined by comparing the observed envelopes to the templates and minimizing the misfit. We then apply the method to nuclear and chemical explosions for a range of yields, depths, and distances. We will review some results from previous work, and show new examples from ordnance explosions in Scandinavia, nuclear explosions in Eurasia, and chemical explosions in Nevada associated with the Source Physics Experiments (SPE).

  11. Genetic polymorphisms and expression of minisatellite mutations in a 3-generation population around the Semipalatinsk nuclear explosion test-site, Kazakhstan.

    PubMed

    Bolegenova, N K; Bekmanov, B O; Djansugurova, L B; Bersimbaev, R I; Salama, S A; Au, W W

    2009-11-01

    We have reported previously that a population near the Semipalatinsk nuclear explosion test site had significantly increased minisatellite mutations (MM), suggesting increased germ-line mutation rates from the exposure in 3 generations. We hypothesize that the MM can be used as a surrogate biomarker for functional genetic alterations, e.g. gene mutations and chromosome aberrations. Therefore, we have investigated the influence of polymorphisms in genes on the expression of MM in the same two populations (247 and 172 individuals, for exposed and control, respectively, in 3 generations), and their relationships with radiation exposure. We have chosen the analyses of three polymorphic DNA - repair genes (XRCC1, XRCC1 and XRCC3) and two xenobiotic detoxification genes (GSTT1 and GSTM1). Among the exposed and in comparison with the wild-type gene, the functionally active XRCC1 Arg194Trp was significantly associated with low MM and over-represented in the exposed compared with the control populations. In a similar analysis, the functionally deficient XRCC1 Arg399Glu and XRCC3 Trp241Met were associated with increased and significantly reduced MM, respectively, but these variant genes were under-represented in the exposed population. Both GSTT1 and GSTM1 nulls were significantly associated with increased MM. The former was under-represented but the latter was significantly over-represented in the exposed compared with the control populations. In summary, the data indicate that the expected enzymatic functions of the polymorphic genes are consistent with the MM expression, except the XRCC1 Arg399Glu variant gene. In addition, the variant genes were retained in the three generations in association with their useful function, except for the GSTM1 null. However, the MM frequencies in the exposed were not consistently and significantly higher than those in the control populations, radiation exposure may therefore not have been the only cause for the high MM frequency among the exposed individuals. Since we studied three generations of citizens, the over- and under-representations of variant genes in the exposed population indicate their persistence and elimination, respectively, from the exposed individuals, suggesting their functional influence on survivability. The latter observation also indicates the complexity of gene and environmental interactions, e.g. the GSTM1 null was significantly over-represented in the exposed population.

  12. A non-imaging polarized terahertz passive system for detecting and identifying concealed explosives

    NASA Astrophysics Data System (ADS)

    Karam, Mostafa A.; Meyer, Doug

    2011-06-01

    Existing terahertz THz systems for detecting concealed explosives are not capable of identifying explosive type which leads to higher false alarm rates. Moreover, some of those systems are imaging systems that invade personal privacy, and require more processing and computational resources. Other systems have no polarization preference which makes them incapable of capturing the geometric features of an explosive. In this study a non-imaging polarized THz passive system for detecting and identifying concealed explosives overcoming the forgoing shortcomings is developed. The system employs a polarized passive THz sensor in acquiring emitted data from a scene that may have concealed explosives. The acquired data are decomposed into their natural resonance frequencies, and the number of those frequencies is used as criteria in detecting the explosive presence. If the presence of an explosive is confirmed, a set of physically based retrieval algorithms is used in extracting the explosive dielectric constant/refractive index value from natural resonance frequencies and amplitudes of associated signals. Comparing the refractive index value against a database of refractive indexes of known explosives identifies the explosive type. As an application, a system having a dual polarized radiometer operating within the frequency band of 0.62- 0.82 THz is presented and used in detecting and identifying person borne C-4 explosive concealed under a cotton garment. The system showed higher efficiencies in detecting and identifying the explosive.

  13. New directions in the science and technology of advanced sheet explosive formulations and the key energetic materials used in the processing of sheet explosives: Emerging trends.

    PubMed

    Talawar, M B; Jangid, S K; Nath, T; Sinha, R K; Asthana, S N

    2015-12-30

    This review presents the work carried out by the international community in the area of sheet explosive formulations and its applications in various systems. The sheet explosive is also named as PBXs and is a composite material in which solid explosive particles like RDX, HMX or PETN are dispersed in a polymeric matrix, forms a flexible material that can be rolled/cut into sheet form which can be applied to any complex contour. The designed sheet explosive must possess characteristic properties such as flexible, cuttable, water proof, easily initiable, and safe handling. The sheet explosives are being used for protecting tanks (ERA), light combat vehicle and futuristic infantry carrier vehicle from different attacking war heads etc. Besides, sheet explosives find wide applications in demolition of bridges, ships, cutting and metal cladding. This review also covers the aspects such as risks and hazard analysis during the processing of sheet explosive formulations, effect of ageing on sheet explosives, detection and analysis of sheet explosive ingredients and the R&D efforts of Indian researchers in the development of sheet explosive formulations. To the best of our knowledge, there has been no review article published in the literature in the area of sheet explosives. Copyright © 2015 Elsevier B.V. All rights reserved.

  14. Explosion risk evaluation during production of coating powder.

    PubMed

    Li, Gang; Yuan, Chunmiao; Chen, Baozhi

    2007-10-22

    Powder coating is widely used in industry to prevent equipment corrosion. More than 600 companies produce coating powder in China, but most do not understand the explosion hazard of such products. In the present investigation the explosibility parameters of a coating powder were determined. Results showed that the coating powder is explosible, though the ignition energy is higher than those of normal dusts such as coal powder and corn starch. Based on these experimental findings, a systematic explosion protection method is proposed, with explosion isolation and explosion venting being adopted as the main protective methods.

  15. Advancing Explosion Source Theory through Experimentation: Results from Seismic Experiments Since the Moratorium on Nuclear Testing

    NASA Astrophysics Data System (ADS)

    Bonner, J. L.; Stump, B. W.

    2011-12-01

    On 23 September 1992, the United States conducted the nuclear explosion DIVIDER at the Nevada Test Site (NTS). It would become the last US nuclear test when a moratorium ended testing the following month. Many of the theoretical explosion seismic models used today were developed from observations of hundreds of nuclear tests at NTS and around the world. Since the moratorium, researchers have turned to chemical explosions as a possible surrogate for continued nuclear explosion research. This talk reviews experiments since the moratorium that have used chemical explosions to advance explosion source models. The 1993 Non-Proliferation Experiment examined single-point, fully contained chemical-nuclear equivalence by detonating over a kiloton of chemical explosive at NTS in close proximity to previous nuclear explosion tests. When compared with data from these nearby nuclear explosions, the regional and near-source seismic data were found to be essentially identical after accounting for different yield scaling factors for chemical and nuclear explosions. The relationship between contained chemical explosions and large production mining shots was studied at the Black Thunder coal mine in Wyoming in 1995. The research led to an improved source model for delay-fired mining explosions and a better understanding of mining explosion detection by the International Monitoring System (IMS). The effect of depth was examined in a 1997 Kazakhstan Depth of Burial experiment. Researchers used local and regional seismic observations to conclude that the dominant mechanism for enhanced regional shear waves was local Rg scattering. Travel-time calibration for the IMS was the focus of the 1999 Dead Sea Experiment where a 10-ton shot was recorded as far away as 5000 km. The Arizona Source Phenomenology Experiments provided a comparison of fully- and partially-contained chemical shots with mining explosions, thus quantifying the reduction in seismic amplitudes associated with partial confinement. The Frozen Rock Experiment in 2006 found only minor differences in seismic coupling for explosions in frozen and unfrozen rock. The seismo-acoustic source function was the focus of the above- and below-ground Humble Redwood explosions (2007, 2009 ) in New Mexico and detonations of rocket motor explosions in Utah. Acoustic travel time calibration for the IMS was accomplished with the 2009 and 2011 100-ton surface explosions in southern Israel. The New England Damage Experiment in 2009 correlated increased shear wave generation with increased rock damage from explosions. Damage from explosions continues to be an important research topic at Nevada's National Center for Nuclear Security with the ongoing Source Physics Experiment. A number of exciting experiments are already planned for the future and thus continue the effort to improve global detection, location, and identification of nuclear explosions.

  16. Nucleoprotein from the unique human infecting Orthobunyavirus of Simbu serogroup (Oropouche virus) forms higher order oligomers in complex with nucleic acids in vitro.

    PubMed

    Murillo, Juliana Londoño; Cabral, Aline Diniz; Uehara, Mabel; da Silva, Viviam Moura; Dos Santos, Juliete Vitorino; Muniz, João Renato Carvalho; Estrozi, Leandro Farias; Fenel, Daphna; Garcia, Wanius; Sperança, Márcia Aparecida

    2018-06-01

    Oropouche virus (OROV) is the unique known human pathogen belonging to serogroup Simbu of Orthobunyavirus genus and Bunyaviridae family. OROV is transmitted by wild mosquitoes species to sloths, rodents, monkeys and birds in sylvatic environment, and by midges (Culicoides paraensis and Culex quinquefasciatus) to man causing explosive outbreaks in urban locations. OROV infection causes dengue fever-like symptoms and in few cases, can cause clinical symptoms of aseptic meningitis. OROV contains a tripartite negative RNA genome encapsidated by the viral nucleocapsid protein (NP), which is essential for viral genome encapsidation, transcription and replication. Here, we reported the first study on the structural properties of a recombinant NP from human pathogen Oropouche virus (OROV-rNP). OROV-rNP was successfully expressed in E. coli in soluble form and purified using affinity and size-exclusion chromatographies. Purified OROV-rNP was analyzed using a series of biophysical tools and molecular modeling. The results showed that OROV-rNP formed stable oligomers in solution coupled with endogenous E. coli nucleic acids (RNA) of different sizes. Finally, electron microscopy revealed a total of eleven OROV-rNP oligomer classes with tetramers (42%) and pentamers (43%) the two main populations and minor amounts of other bigger oligomeric states, such as hexamers, heptamers or octamers. The different RNA sizes and nucleotide composition may explain the diversity of oligomer classes observed. Besides, structural differences among bunyaviruses NP can be used to help in the development of tools for specific diagnosis and epidemiological studies of this group of viruses.

  17. System for fracturing an underground geologic formation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mace, Jonathan L.; Tappan, Bryce C.; Seitz, Gerald J.

    2017-03-14

    An explosive system for fracturing an underground geologic formation adjacent to a wellbore can comprise a plurality of explosive units comprising an explosive material contained within the casing, and detonation control modules electrically coupled to the plurality of explosive units and configured to cause a power pulse to be transmitted to at least one detonator of at least one of the plurality of explosive units for detonation of the explosive material. The explosive units are configured to be positioned within a wellbore in spaced apart positions relative to one another along a string with the detonation control modules positioned adjacentmore » to the plurality of explosive units in the wellbore, such that the axial positions of the explosive units relative to the wellbore are at least partially based on geologic properties of the geologic formation adjacent the wellbore.« less

  18. Explosion Generated Seismic Waves and P/S Methods of Discrimination from Earthquakes with Insights from the Nevada Source Physics Experiments

    NASA Astrophysics Data System (ADS)

    Walter, W. R.; Ford, S. R.; Pitarka, A.; Pyle, M. L.; Pasyanos, M.; Mellors, R. J.; Dodge, D. A.

    2017-12-01

    The relative amplitudes of seismic P-waves to S-waves are effective at identifying underground explosions among a background of natural earthquakes. These P/S methods appear to work best at frequencies above 2 Hz and at regional distances ( >200 km). We illustrate this with a variety of historic nuclear explosion data as well as with the recent DPRK nuclear tests. However, the physical basis for the generation of explosion S-waves, and therefore the predictability of this P/S technique as a function of path, frequency and event properties such as size, depth, and geology, remains incompletely understood. A goal of current research, such as the Source Physics Experiments (SPE), is to improve our physical understanding of the mechanisms of explosion S-wave generation and advance our ability to numerically model and predict them. The SPE conducted six chemical explosions between 2011 and 2016 in the same borehole in granite in southern Nevada. The explosions were at a variety of depths and sizes, ranging from 0.1 to 5 tons TNT equivalent yield. The largest were observed at near regional distances, with P/S ratios comparable to much larger historic nuclear tests. If we control for material property effects, the explosions have very similar P/S ratios independent of yield or magnitude. These results are consistent with explosion S-waves coming mainly from conversion of P- and surface waves, and are inconsistent with source-size based models. A dense sensor deployment for the largest SPE explosion allowed this conversion to be mapped in detail. This is good news for P/S explosion identification, which can work well for very small explosions and may be ultimately limited by S-wave detection thresholds. The SPE also showed explosion P-wave source models need to be updated for small and/or deeply buried cases. We are developing new P- and S-wave explosion models that better match all the empirical data. Historic nuclear explosion seismic data shows that the media in which the explosion takes place is quite important. These material property effects can surprisingly degrade the seismic waveform correlation of even closely spaced explosions in different media. The next phase of the SPE will contrast chemical explosions in dry alluvium with the prior SPE explosions in granite and historic nuclear tests in a variety of media.

  19. DoD Contractors’ Safety Manual for Ammunition and Explosives.

    DTIC Science & Technology

    1997-09-01

    grit, and other foreign material into operating buildings. 9. Windows and skylights . Non-shatterable glazing is preferred where an explosion...with the explosives being processed. Dull or damaged tools shall not be used for machining high explosives. k. The explosives products resulting from

  20. 30 CFR 57.6201 - Separation of transported explosive material.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Separation of transported explosive material... MINES Explosives Transportation-Surface and Underground § 57.6201 Separation of transported explosive material. Detonators shall not be transported on the same vehicle or conveyance with other explosives...

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