Science.gov

Sample records for human projected area

  1. Human Genome Project

    SciTech Connect

    Block, S.; Cornwall, J.; Dally, W.; Dyson, F.; Fortson, N.; Joyce, G.; Kimble, H. J.; Lewis, N.; Max, C.; Prince, T.; Schwitters, R.; Weinberger, P.; Woodin, W. H.

    1998-01-04

    The study reviews Department of Energy supported aspects of the United States Human Genome Project, the joint National Institutes of Health/Department of Energy program to characterize all human genetic material, to discover the set of human genes, and to render them accessible for further biological study. The study concentrates on issues of technology, quality assurance/control, and informatics relevant to current effort on the genome project and needs beyond it. Recommendations are presented on areas of the genome program that are of particular interest to and supported by the Department of Energy.

  2. The human genome project.

    PubMed Central

    Olson, M V

    1993-01-01

    The Human Genome Project in the United States is now well underway. Its programmatic direction was largely set by a National Research Council report issued in 1988. The broad framework supplied by this report has survived almost unchanged despite an upheaval in the technology of genome analysis. This upheaval has primarily affected physical and genetic mapping, the two dominant activities in the present phase of the project. Advances in mapping techniques have allowed good progress toward the specific goals of the project and are also providing strong corollary benefits throughout biomedical research. Actual DNA sequencing of the genomes of the human and model organisms is still at an early stage. There has been little progress in the intrinsic efficiency of DNA-sequence determination. However, refinements in experimental protocols, instrumentation, and project management have made it practical to acquire sequence data on an enlarged scale. It is also increasingly apparent that DNA-sequence data provide a potent means of relating knowledge gained from the study of model organisms to human biology. There is as yet little indication that the infusion of technology from outside biology into the Human Genome Project has been effectively stimulated. Opportunities in this area remain large, posing substantial technical and policy challenges. PMID:8506271

  3. Humane Education Projects Handbook.

    ERIC Educational Resources Information Center

    Junior League of Ogden, UT.

    This handbook was developed to promote interest in humane education and to encourage the adoption of humane education projects. Although specifically designed to assist Junior Leagues in developing such projects, the content should prove valuable to animal welfare organizations, zoos, aquariums, nature centers, and other project-oriented groups…

  4. The Human Variome Project Beijing meeting.

    PubMed

    Smith, Timothy D; Robinson, Helen M; Cotton, Richard G H

    2012-04-01

    The Human Variome Project Beijing Meeting, a joint meeting of the Human Variome Project Consortium and the Human Variome Project Chinese Node, was held in Beijing, 8th-12th of December, 2011. The aim of the Human Variome Project is to ensure that all information on genetic variation can be collected, curated, interpreted and shared freely and openly. The meeting officially welcomed the Human Variome Project Chinese Node as a partner of the Human Variome Project and focused on those areas where collaborations between China and the global Human Variome Project Consortium are required to develop and extend the coverage of international gene/disease specific databases.

  5. Project analysis and integration area

    NASA Technical Reports Server (NTRS)

    1986-01-01

    The objective of the Project Analysis and Integration Area (PA&I) is to support the planning, analysis, integration, and decision making activities of the Flat-plate Solar Array FSA) Project. Accordingly, PA&I supports the Project by developing and documenting Project plans based, in part, on the technical and economic assessments performed by PA&I of the various technical options. Goals for module technical performance and costs, derived from National Photovoltaics Program goals, are established by PA&I for each of the major technical activities in the Project. Assessments of progress toward achievement of goals are made to guide decision making within the Project.

  6. Visible Human Project

    MedlinePlus

    ... Toxicology Health Services Research & Public Health Health Information Technology NLM for You Grants & Funding Meaningful Use Tools Training & Outreach Network of Medical Libraries Regional Activities Careers @ NLM Mobile Gallery Site Navigation Home The Visible Human Project ® ...

  7. The Human Toxome Project

    EPA Science Inventory

    The Human Toxome project, funded as an NIH Transformative Research grant 2011--‐ 2016, is focused on developing the concepts and the means for deducing, validating, and sharing molecular Pathways of Toxicity (PoT). Using the test case of estrogenic endocrine disruption, the respo...

  8. [Projective identification in human relations].

    PubMed

    Göka, Erol; Yüksel, Fatih Volkan; Göral, F Sevinç

    2006-01-01

    Melanie Klein, one of the pioneers of Object Relations Theory, first defined "projective identification", which is regarded as one of the most efficacious psychoanalytic concepts after the discovery of the "unconscious". Examination of the literature on "projective identification" shows that there are various perspectives and theories suggesting different uses of this concept. Some clinicians argue that projective identification is a primitive defense mechanism observed in severe psychopathologies like psychotic disorder and borderline personality disorder, where the intra-psychic structure has been damaged severely. Others suggest it to be an indispensable part of the transference and counter-transference between the therapist and the patient during psychotherapy and it can be used as a treatment material in the therapy by a skillful therapist. The latter group expands the use of the concept through normal daily relationships by stating that projective identification is one type of communication and part of the main human relation mechanism operating in all close relationships. Therefore, they suggest that projective identification has benign forms experienced in human relations as well as malign forms seen in psychopathologies. Thus, discussions about the definition of the concept appear complex. In order to clarify and overcome the complexity of the concept, Melanie Klein's and other most important subsequent approaches are discussed in this review article. Thereby, the article aims to explain its important function in understanding the psychopathologies, psychotherapeutic relationships and different areas of normal human relations.

  9. Human Relations Education Project. Final Evaluation Report.

    ERIC Educational Resources Information Center

    Buffalo Board of Education, NY.

    This project did the planning and pilot phases of an effort to improve the teaching of human relations in grades K-12 of public and private schools in the Buffalo-Niagara Falls metropolitan area. In the pilot phase, the project furnished on-the-job training for approximately 70 schools. The training was given by teams of human relations…

  10. The Human Variome Project.

    PubMed

    Burn, John; Watson, Michael

    2016-06-01

    The practical realization of genomics has meant a growing realization that variant interpretation is a major barrier to practical use of DNA sequence data. The late Professor Dick Cotton devoted his life to innovation in molecular genetics and was a prime mover in the international response to the need to understand the "variome." His leadership resulted in the launch first of the Human Genetic Variation Society and then, in 2006, an international agreement to launch the Human Variome Project (HVP), aimed at data integration enabled by standards and infrastructure of the databases of variants being identified in families with a range of inherited disorders. The project attracted a network of affiliates across 81 countries and earned formal recognition by UNESCO, which now hosts its biennial meetings. It has also signed a Memorandum of Understanding with the World Health Organization. Future progress will depend on longer term secure funding and integration with the efforts of the genomics community where the rapid advances in sequencing technology have enabled variant capture on a previously unimaginable scale. Efforts are underway to integrate the efforts of HVP with those of the Global Alliance for Genomics and Health to provide a lasting legacy of Dick Cotton's vision.

  11. The Human Genome Diversity Project

    SciTech Connect

    Cavalli-Sforza, L.

    1994-12-31

    The Human Genome Diversity Project (HGD Project) is an international anthropology project that seeks to study the genetic richness of the entire human species. This kind of genetic information can add a unique thread to the tapestry knowledge of humanity. Culture, environment, history, and other factors are often more important, but humanity`s genetic heritage, when analyzed with recent technology, brings another type of evidence for understanding species` past and present. The Project will deepen the understanding of this genetic richness and show both humanity`s diversity and its deep and underlying unity. The HGD Project is still largely in its planning stages, seeking the best ways to reach its goals. The continuing discussions of the Project, throughout the world, should improve the plans for the Project and their implementation. The Project is as global as humanity itself; its implementation will require the kinds of partnerships among different nations and cultures that make the involvement of UNESCO and other international organizations particularly appropriate. The author will briefly discuss the Project`s history, describe the Project, set out the core principles of the Project, and demonstrate how the Project will help combat the scourge of racism.

  12. Project for Area Concentration Achievement Testing (PACAT).

    ERIC Educational Resources Information Center

    Austin Peay State Univ., Clarksville, TN.

    The history of the Project for Area Concentration Achievement Testing (PACAT), a university based national curriculum assessment project, is described in this report. The project performs surveys of academic curricula by content area, collects examination items from the faculty of participating departments, and constructs, distributes, and scores…

  13. The Digital Humanities as a Humanities Project

    ERIC Educational Resources Information Center

    Svensson, Patrik

    2012-01-01

    This article argues that the digital humanities can be seen as a humanities project in a time of significant change in the academy. The background is a number of scholarly, educational and technical challenges, the multiple epistemic traditions linked to the digital humanities, the potential reach of the field across and outside the humanities,…

  14. Ashland Area Support Substation Project

    SciTech Connect

    Not Available

    1992-06-01

    The Bonneville Power Administration (BPA) provides wholesale electric service to the City of Ashland (the City) by transferring power over Pacific Power Light Company's (PP L) 115-kilovolt (kV) transmission lines and through PP L's Ashland and Oak Knoll Substations. The City distributes power over a 12.5-kV system which is heavily loaded during winter peak periods and which has reached the limit of its ability to serve peak loads in a reliable manner. Peak loads under normal winter conditions have exceeded the ratings of the transformers at both the Ashland and Oak Knoll Substations. In 1989, the City modified its distribution system at the request of PP L to allow transfer of three megawatts (MW's) of electric power from the overloaded Ashland Substation to the Oak Knoll Substation. In cooperation with PP L, BPA installed a temporary 6-8 megavolt-amp (MVA) 115-12.5-kV transformer for this purpose. This additional transformer, however, is only a temporary remedy. BPA needs to provide additional, reliable long-term service to the Ashland area through additional transformation in order to keep similar power failures from occurring during upcoming winters in the Ashland area. The temporary installation of another 20-MVA mobile transformer at the Ashland Substation and additional load curtailment are currently being studied to provide for sustained electrical service by the peak winter period 1992. Two overall electrical plans-of-service are described and evaluated in this report. One of them is proposed for action. Within that proposed plan-of-service are location options for the substation. Note that descriptions of actions that may be taken by the City of Ashland are based on information provided by them.

  15. DSN human factors project

    NASA Technical Reports Server (NTRS)

    Chafin, R. L.; Martin, T. H.

    1980-01-01

    The project plan was to hold focus groups to identify the factors influencing the ease of use characteristics of software and to bond the problem. A questionnaire survey was conducted to evaluate those factors which were more appropriately measured with that method. The performance oriented factors were analyzed and relationships hypothesized. The hypotheses were put to test in the experimental phase of the project. In summary, the initial analysis indicates that there is an initial performance effect favoring computer controlled dialogue but the advantage fades fast as operators become experienced. The user documentation style is seen to have a significant effect on performance. The menu and prompt command formats are preferred by inexperienced operators. The short form mnemonic is least favored. There is no clear best command format but the short form mnemonic is clearly the worst.

  16. Driftless Area Initiative Biomass Energy Project

    SciTech Connect

    Wright, Angie; Bertjens, Steve; Lieurance, Mike; Berguson, Bill; Buchman, Dan

    2012-12-31

    The Driftless Area Initiative Biomass Energy Project evaluated the potential for biomass energy production and utilization throughout the Driftless Region of Illinois, Iowa, Minnesota and Wisconsin. The research and demonstration aspect of the project specifically focused on biomass energy feedstock availability and production potential in the region, as well as utilization potential of biomass feedstocks for heat, electrical energy production, or combined heat and power operations. The Driftless Region was evaluated because the topography of the area offers more acres of marginal soils on steep slopes, wooded areas, and riparian corridors than the surrounding “Corn Belt”. These regional land characteristics were identified as potentially providing opportunity for biomass feedstock production that could compete with traditional agriculture commodity crops economically. The project researched establishment methods and costs for growing switchgrass on marginal agricultural lands to determine the economic and quantitative feasibility of switchgrass production for biomass energy purposes. The project was successful in identifying the best management and establishment practices for switchgrass in the Driftless Area, but also demonstrated that simple economic payback versus commodity crops could not be achieved at the time of the research. The project also analyzed the availability of woody biomass and production potential for growing woody biomass for large scale biomass energy production in the Driftless Area. Analysis determined that significant resources exist, but costs to harvest and deliver to the site were roughly 60% greater than that of natural gas at the time of the study. The project contributed significantly to identifying both production potential of biomass energy crops and existing feedstock availability in the Driftless Area. The project also analyzed the economic feasibility of dedicated energy crops in the Driftless Area. High commodity crop prices

  17. St. Louis Area Earthquake Hazards Mapping Project

    USGS Publications Warehouse

    Williams, Robert A.; Steckel, Phyllis; Schweig, Eugene

    2007-01-01

    St. Louis has experienced minor earthquake damage at least 12 times in the past 200 years. Because of this history and its proximity to known active earthquake zones, the St. Louis Area Earthquake Hazards Mapping Project will produce digital maps that show variability of earthquake hazards in the St. Louis area. The maps will be available free via the internet. They can be customized by the user to show specific areas of interest, such as neighborhoods or transportation routes.

  18. Bridging Disciplines with the Riparian Area Management Project

    ERIC Educational Resources Information Center

    Cockerill, Kristan M.; Titus, Jonathan H.

    2004-01-01

    Faculty at Columbia University's Earth Semester created the interdisciplinary Riparian Area Management Project to help students integrate information and skills from life sciences, geosciences, social sciences, and humanities focused coursework. Structured as a "consulting" contract, students were required to make a policy recommendation…

  19. 78 FR 66695 - Loveland Area Projects, Colorado River Storage Project, Pacific Northwest-Pacific Southwest...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-06

    ... Area Power Administration Loveland Area Projects, Colorado River Storage Project, Pacific Northwest..., Colorado River Storage Project Manager, Colorado River Storage Project Management Center, 150 East Social.... Thomas Hackett, Rates Team Lead, Colorado River Storage Project Management Center, 150 East Social...

  20. CATSKILL AREA PROJECT IN SMALL SCHOOL DESIGN.

    ERIC Educational Resources Information Center

    Catskill Area Project in Small School Design, Oneonta, NY.

    CHARACTERISTICS OF THE SMALL SCHOOL, AS PROPOSED BY THE PROJECT, ARE LISTED. FIVE AREAS OF SCHOOL OPERATION ARE DISCUSSED IN DETAIL--(1) MULTIPLE CLASSES, INCLUDING SUPERVISED CORRESPONDENCE COURSES, (2) FLEXIBLE SCHEDULES, (3) USE OF SCHOOL AIDES, (4) USES OF ELECTRONIC COMMUNICATION, AND (5) SHARED SERVICES AND TALENTED YOUTH. A MAP LOCATING THE…

  1. Freihoelser Forst Local Training Area rehabilitation project

    SciTech Connect

    Hinchman, R.R.; Zellmer, S.D.; Johnson, D.O.; Severinghaus, W.D.; Brent, J.J. . Environmental Div.)

    1991-12-01

    Intensive and continued use of the Freihoelser Forst Local Training Area (LTA) for military training activities had resulted in serious environmental problems, exemplified by a lack of vegetative cover and severe erosion by water and wind. The project's goal was to develop and demonstrate rapid, cost-effective methods to stabilize the LTA's barren, eroding maneuver areas and make training conditions more realistic. The major factors limiting rehabilitation efforts were the sandy, infertile, and acidic soils. The project was conducted in two phases. Phase I demonstrated and evaluated three separate rehabilitation treatments ranging in cost from moderate to expensive. Each treatment used a different type of soil amendment (fertilizer and straw, compost, or chicken manure), but all used identical seedbed preparation methods and seed mixtures. Phase I was conducted on relatively small replicated plots and was monitored three times during each growing season. All three treatments satisfactorily reestablished vegetation and controlled erosion. Because of their small size, the Phase I demonstration plots had only a minor stabilizing effect on the erosion problems of the LTA as a whole. The Phase II treatment was based on lessons teamed from Phase I and from other revegetation projects in Germany. Phase II revegetated a large area of the LTA, which included nearly all of the most severely disturbed land. Phase II, which was monitored in the same way as Phase I but for a shorter period of time, was highly successful in stabilizing most areas treated. The revegetation plant community was dominated by native grasses and legumes that stabilized the loose, sandy soils and improved the training realism of a major portion of the LTA.

  2. The NIH Human Microbiome Project.

    PubMed

    Peterson, Jane; Garges, Susan; Giovanni, Maria; McInnes, Pamela; Wang, Lu; Schloss, Jeffery A; Bonazzi, Vivien; McEwen, Jean E; Wetterstrand, Kris A; Deal, Carolyn; Baker, Carl C; Di Francesco, Valentina; Howcroft, T Kevin; Karp, Robert W; Lunsford, R Dwayne; Wellington, Christopher R; Belachew, Tsegahiwot; Wright, Michael; Giblin, Christina; David, Hagit; Mills, Melody; Salomon, Rachelle; Mullins, Christopher; Akolkar, Beena; Begg, Lisa; Davis, Cindy; Grandison, Lindsey; Humble, Michael; Khalsa, Jag; Little, A Roger; Peavy, Hannah; Pontzer, Carol; Portnoy, Matthew; Sayre, Michael H; Starke-Reed, Pamela; Zakhari, Samir; Read, Jennifer; Watson, Bracie; Guyer, Mark

    2009-12-01

    The Human Microbiome Project (HMP), funded as an initiative of the NIH Roadmap for Biomedical Research (http://nihroadmap.nih.gov), is a multi-component community resource. The goals of the HMP are: (1) to take advantage of new, high-throughput technologies to characterize the human microbiome more fully by studying samples from multiple body sites from each of at least 250 "normal" volunteers; (2) to determine whether there are associations between changes in the microbiome and health/disease by studying several different medical conditions; and (3) to provide both a standardized data resource and new technological approaches to enable such studies to be undertaken broadly in the scientific community. The ethical, legal, and social implications of such research are being systematically studied as well. The ultimate objective of the HMP is to demonstrate that there are opportunities to improve human health through monitoring or manipulation of the human microbiome. The history and implementation of this new program are described here.

  3. The NIH Human Microbiome Project

    PubMed Central

    Peterson, Jane; Garges, Susan; Giovanni, Maria; McInnes, Pamela; Wang, Lu; Schloss, Jeffery A.; Bonazzi, Vivien; McEwen, Jean E.; Wetterstrand, Kris A.; Deal, Carolyn; Baker, Carl C.; Di Francesco, Valentina; Howcroft, T. Kevin; Karp, Robert W.; Lunsford, R. Dwayne; Wellington, Christopher R.; Belachew, Tsegahiwot; Wright, Michael; Giblin, Christina; David, Hagit; Mills, Melody; Salomon, Rachelle; Mullins, Christopher; Akolkar, Beena; Begg, Lisa; Davis, Cindy; Grandison, Lindsey; Humble, Michael; Khalsa, Jag; Little, A. Roger; Peavy, Hannah; Pontzer, Carol; Portnoy, Matthew; Sayre, Michael H.; Starke-Reed, Pamela; Zakhari, Samir; Read, Jennifer; Watson, Bracie; Guyer, Mark

    2009-01-01

    The Human Microbiome Project (HMP), funded as an initiative of the NIH Roadmap for Biomedical Research (http://nihroadmap.nih.gov), is a multi-component community resource. The goals of the HMP are: (1) to take advantage of new, high-throughput technologies to characterize the human microbiome more fully by studying samples from multiple body sites from each of at least 250 “normal” volunteers; (2) to determine whether there are associations between changes in the microbiome and health/disease by studying several different medical conditions; and (3) to provide both a standardized data resource and new technological approaches to enable such studies to be undertaken broadly in the scientific community. The ethical, legal, and social implications of such research are being systematically studied as well. The ultimate objective of the HMP is to demonstrate that there are opportunities to improve human health through monitoring or manipulation of the human microbiome. The history and implementation of this new program are described here. PMID:19819907

  4. All about the Human Genome Project (HGP)

    MedlinePlus

    ... Genome Resources Access to the full human sequence All About The Human Genome Project (HGP) The Human ... an international research effort to sequence and map all of the genes - together known as the genome - ...

  5. 78 FR 79444 - Loveland Area Projects-2025 Power Marketing Initiative

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... Area Power Administration Loveland Area Projects--2025 Power Marketing Initiative AGENCY: Western Area Power Administration, DOE. ACTION: Notice of Final 2025 Power Marketing Initiative. SUMMARY: Western Area Power Administration (Western), Rocky Mountain Region, a Federal power marketing agency of...

  6. Climate Change Projections for African Urban Areas

    NASA Astrophysics Data System (ADS)

    Simonis, Ingo; Engelbrecht, Francois; Bucchignani, Edoardo; Mercogliano, Paola; Naidoo, Mogesh

    2013-04-01

    Mainly driven by changes in the orbital characteristics of Earth around the sun, the planet's climate has been continuously changing over periods of tens of thousands of years. However, the warming that has been detected in the Earth's atmosphere over the last century is occurring at a rate that cannot be explained by any known natural cycle. Main-stream science has indeed reached consensus that the 'enhanced green house effect', caused by the interplay of incoming short-wave irradiation, outgoing long-wave radiation and the absorption of energy by enhanced levels of CO2 and water vapour in the troposphere, is the main forcing mechanism responsible for the phenomena of global warming. The enhanced greenhouse effect strengthens the 'natural green house effect' that results from the CO2 and water vapour occurring naturally in the atmosphere. The continuous burning of fossil fuels since the industrial revolution and the simultaneous degradation of large forests, are the main reasons for the increase in CO2 concentrations in the atmosphere. The availability of climate change projection data varies considerably for different areas on Earth. Whereas the data centres storing climate change projections for Europe and North America now store petabytes of data, regionally downscaled projections for Africa are rarely available. In the context of the research project CLUVA, (Assessing vulnerability of urban systems, populations and goods in relation to natural and man-made disasters in Africa, co-funded by the European Commission under grant agreement no: 265137), the Council for Industrial and Scientific Research (CSIR) in South Africa and the Centro Euro-Mediterraneo sui Cambiamenti Climatici (CMCC) in Italy have produced a large set of projections of climate change over Africa, covering the time period 1950 to 2100. Through the collaboration between CMCC and CSIR, a multi-model ensemble of eight high-resolution simulations of climate change over parts of West and East

  7. The Human Connectome Project's neuroimaging approach.

    PubMed

    Glasser, Matthew F; Smith, Stephen M; Marcus, Daniel S; Andersson, Jesper L R; Auerbach, Edward J; Behrens, Timothy E J; Coalson, Timothy S; Harms, Michael P; Jenkinson, Mark; Moeller, Steen; Robinson, Emma C; Sotiropoulos, Stamatios N; Xu, Junqian; Yacoub, Essa; Ugurbil, Kamil; Van Essen, David C

    2016-08-26

    Noninvasive human neuroimaging has yielded many discoveries about the brain. Numerous methodological advances have also occurred, though inertia has slowed their adoption. This paper presents an integrated approach to data acquisition, analysis and sharing that builds upon recent advances, particularly from the Human Connectome Project (HCP). The 'HCP-style' paradigm has seven core tenets: (i) collect multimodal imaging data from many subjects; (ii) acquire data at high spatial and temporal resolution; (iii) preprocess data to minimize distortions, blurring and temporal artifacts; (iv) represent data using the natural geometry of cortical and subcortical structures; (v) accurately align corresponding brain areas across subjects and studies; (vi) analyze data using neurobiologically accurate brain parcellations; and (vii) share published data via user-friendly databases. We illustrate the HCP-style paradigm using existing HCP data sets and provide guidance for future research. Widespread adoption of this paradigm should accelerate progress in understanding the brain in health and disease.

  8. 75 FR 48986 - Northwest Area Water Supply Project, North Dakota

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-12

    ... Bureau of Reclamation Northwest Area Water Supply Project, North Dakota AGENCY: Bureau of Reclamation... 1969 (NEPA) on a Supplemental Environmental Impact Statement (EIS) for the Northwest Area Water Supply..., Northwest Area Water Supply Project EIS, Bureau of Reclamation, Dakotas Area Office, P.O. Box 1017,...

  9. Spatial augmented reality based high accuracy human face projection

    NASA Astrophysics Data System (ADS)

    Li, Dong; Xie, Jinghui; Li, Yufeng; Weng, Dongdong; Liu, Yue

    2015-08-01

    This paper discusses the imaging principles and the technical difficulties of spatial augmented reality based human face projection. A novel geometry correction method is proposed to realize fast, high-accuracy face model projection. Using a depth camera to reconstruct the projected object, the relative position from the rendered model to the projector can be accessed and the initial projection image is generated. Then the projected image is distorted by using Bezier interpolation to guarantee that the projected texture matches with the object surface. The proposed method is under a simple process flow and can achieve high perception registration of virtual and real object. In addition, this method has a good performance in the condition that the reconstructed model is not exactly same with the rendered virtual model which extends its application area in the spatial augmented reality based human face projection.

  10. Project Approach: Celebrating Human Dimensions of Learning.

    ERIC Educational Resources Information Center

    Elliott, Mary Jane

    This paper presents reflections on the power of project work as it enhances the character development and self-awareness of the young child. Examples from projects illustrate the development of these human values based on project investigations of 4- and 5-year-old children from Hong Kong International School. The first set of investigations…

  11. 75 FR 49518 - Northwest Area Water Supply Project, North Dakota

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-13

    ... Bureau of Reclamation Northwest Area Water Supply Project, North Dakota AGENCY: Bureau of Reclamation... 1969 (NEPA) on a Supplemental Environmental Impact Statement (EIS) for the Northwest Area Water Supply... Water Supply Project EIS, Bureau of Reclamation, Dakotas Area Office, P.O. Box 1017, Bismarck, ND...

  12. Selecting Map Projections in Minimizing Area Distortions in GIS Applications.

    PubMed

    Yildirim, Faruk; Kaya, Ahmet

    2008-12-03

    Varioussoftware for Geographical Information Systems (GISs) have been developed and used in many different engineering projects. In GIS applications, map coverage is important in terms of performing reliable and meaningful queries. Map projections can be conformal, equal-area and equidistant. The goal of an application plays an important role in choosing one of those projections. Choosing the equal-area projection for an application in which area information is used (forestry, agriculture, ecosystem etc) reduces the amount of distortion on the area, but many users using GIS ignore this fact and continue to use applications with present map sheets no matter in what map projection it is. For example, extracting area information from data whose country system's map sheet is in conformal projection is relatively more distorted, compared to an equal-area projection one. The goal of this study is to make the best decision in choosing the most proper equal-area projection among the choices provided by ArcGIS 9.0, which is a popular GIS software package, and making a comparison on area errors when conformal projection is used. In this study, the area of parcels chosen in three different regions and geographic coordinates and whose sizes vary between 0.01 to 1,000,000 ha are calculated according to Transversal Mercator (TM, 3°), Universal Transversal Mercator (UTM, 6°) and 14 different equal-area projections existing in the ArcGIS 9.0 GIS software package. The parcel areas calculated with geographical coordinates are accepted as definite. The difference between the sizes calculated according to projection coordinates and real sizes of the parcels are determined. Consequently, the appropriate projections are decided for the areas smaller and equal than 1,000 ha and greater than 1,000 ha in the GIS software package.

  13. Standardizing immunophenotyping for the Human Immunology Project.

    PubMed

    Maecker, Holden T; McCoy, J Philip; Nussenblatt, Robert

    2012-02-17

    The heterogeneity in the healthy human immune system, and the immunological changes that portend various diseases, have been only partially described. Their comprehensive elucidation has been termed the 'Human Immunology Project'. The accurate measurement of variations in the human immune system requires precise and standardized assays to distinguish true biological changes from technical artefacts. Thus, to be successful, the Human Immunology Project will require standardized assays for immunophenotyping humans in health and disease. A major tool in this effort is flow cytometry, which remains highly variable with regard to sample handling, reagents, instrument setup and data analysis. In this Review, we outline the current state of standardization of flow cytometry assays and summarize the steps that are required to enable the Human Immunology Project.

  14. Epidemiology of fascioliasis in human endemic areas.

    PubMed

    Mas-Coma, S

    2005-09-01

    Considered a secondary zoonotic disease until the mid-1990s, human fascioliasis is at present emerging or re-emerging in many countries, including increases of prevalence and intensity and geographical expansion. Research in recent years has justified the inclusion of fascioliasis in the list of important human parasitic diseases. At present, fascioliasis is a vector-borne disease presenting the widest known latitudinal, longitudinal and altitudinal distribution. Fasciola hepatica has succeeded in expanding from its European original geographical area to colonize five continents, despite theoretical restrictions related to its biology and in turn dependent upon environmental and human activities. Among the different epidemiological situations, human hypo- to hyperendemic areas, including epidemics, are noteworthy. A global analysis of the distribution of human cases shows that the expected correlation between animal and human fascioliasis only appears at a basic level. Areas presenting very high human prevalences and intensities, especially in children and females, have been recently described. In hypo- to hyperendemic areas of Central and South America, Europe, Africa and Asia, human fascioliasis presents a range of epidemiological characteristics related to a wide diversity of environments. Thus far well-known epidemiological patterns of fascioliasis may not always explain the transmission characteristics in any given area and control measures should consider the results of ecoepidemiological studies undertaken in the zones concerned.

  15. Sediment Properties: E-Area Completion Project

    SciTech Connect

    Millings, M.; Bagwell, L.; Amidon, M.; Dixon, K.

    2011-04-29

    To accommodate a future need for additional waste disposal facilities at the Savannah River Site, the Solid Waste Management Division (SWMD) designated nine additional plots for development (Kasraii 2007; SRS 2010); these plots are collectively known as the E Area Completion Project (ECP). Subsurface samples were collected from ECP plots 6, 7, 8 and 9 (Figure 1) for chemical and physical property analyses to support Performance Assessment (PA) and Special Analyses (SA) modeling. This document summarizes the sampling and analysis scheme and the resultant data, and provides interpretations of the data particularly in reference to existing soil property data. Analytical data in this document include: gamma log, cone penetrometer log, grain size (sieve and hydrometer), water retention, saturated hydraulic conductivity (falling head permeameter), porosity, dry bulk density, total organic carbon, x-ray diffraction, and x-ray fluorescence data. SRNL provided technical and safety oversight for the fieldwork, which included completion of eight soil borings, four geophysical logs, and the collection of 522 feet of core and 33 Shelby tubes from ECP plots 6, 7, 8, and 9. Boart Longyear provided sonic drilling and logging services. Two soil borings were completed at each location. The first set of boreholes extended into (but did not fully penetrate) the Warley Hill Formation. These boreholes were continuously cored, then geophysically (gamma ray) logged. The recovered core was split, photographed, and described; one half of the core was archived at SRS's Core Lab facilities, and the remaining half was consumed as necessary for testing at SRS and off-site labs. Core descriptions and geophysical data were used to calculate target elevations for Shelby tube samples, which were obtained from the second set of boreholes. Shelby tubes were shipped to MACTEC Engineering and Consulting Inc. (MACTEC) in Atlanta for physical property testing. SRNL deployed their Site Characterization

  16. Human mast cell transcriptome project.

    PubMed

    Saito, H; Nakajima, T; Matsumoto, K

    2001-05-01

    After draft reading of the human genome sequence, systemic analysis of the transcriptome (the whole transcripts present in a cell) is progressing especially in commonly available cell types. Until recently, human mast cells were not commonly available. We have succeeded to generate a substantial number of human mast cells from umbilical cord blood and from adult peripheral blood progenitors. Then, we have examined messenger RNA selectively transcribed in these mast cells using high-density oligonucleotide probe arrays. Many unexpected but important transcripts were selectively expressed in human mast cells. We discuss the results obtained from transcriptome screening by introducing our data regarding mast-cell-specific genes.

  17. Attitudes towards the Human Genome Project.

    ERIC Educational Resources Information Center

    Shahroudi, Julie; Shaw, Geraldine

    Attitudes concerning the Human Genome Project were reported by faculty (N=40) and students (N=66) from a liberal arts college. Positive attitudes toward the project involved privacy, insurance and health, economic purposes, reproductive purposes, genetic counseling, religion and overall opinions. Negative attitudes were expressed regarding…

  18. JSC Human Life Sciences Project

    NASA Technical Reports Server (NTRS)

    1998-01-01

    This section of the Life and Microgravity Spacelab (LMS) publication includes articles entitled: (1) E029 - Magnetic Resonance Imaging after Exposure to Microgravity; (2) E030 - Extended Studies of Pulmonary Function in Weightlessness; (3) E074 - Direct Measurement of the Initial Bone Response to Spaceflight in Humans; (4) E401 - The Effects of Microgravity on Skeletal Muscle Contractile Properties; (5) E407 - Effects of Microgravity on the Biochemical and Bioenergetic Characteristics of Human Skeletal Muscle; (6) E410 - Torso Rotation Experiment; (7) E920 - Effect of Weightlessness on Human Single Muscle Fiber Function; (8) E948 - Human Sleep, Circadian Rhythms and Performance in Space; (9) E963 - Microgravity Effects on Standardized Cognitive Performance Measures; and (10) E971 - Measurement of Energy Expenditures During Spaceflight Using the Doubly Labeled Water Method

  19. Scientific Goals of the Human Genome Project.

    ERIC Educational Resources Information Center

    Wills, Christopher

    1993-01-01

    The Human Genome Project, an effort to sequence all the DNA of a human cell, is needed to better understand the behavior of chromosomes during cell division, with the ultimate goal of understanding the specific genes contributing to specific diseases and disabilities. (MSE)

  20. Information Presentation: Human Research Program - Space Human Factors and Habitability, Space Human Factors Engineering Project

    NASA Technical Reports Server (NTRS)

    Holden, Kristina L.; Sandor, Aniko; Thompson, Shelby G.; Kaiser, Mary K.; McCann, Robert S.; Begault, D. R.; Adelstein, B. D.; Beutter, B. R.; Wenzel, E. M.; Godfroy, M.; Stone, L. S.

    2010-01-01

    The goal of the Information Presentation Directed Research Project (DRP) is to address design questions related to the presentation of information to the crew. The major areas of work, or subtasks, within this DRP are: 1) Displays, 2) Controls, 3) Electronic Procedures and Fault Management, and 4) Human Performance Modeling. This DRP is a collaborative effort between researchers atJohnson Space Center and Ames Research Center. T

  1. South Carolina: Charleston County Area Project Impact Environmental Education Program (A Former EPA CARE Project)

    EPA Pesticide Factsheets

    The Charleston County Area Project Impact is the recipient of a Level II CARE cooperative agreement. The project is under the direction of the Charleston County Building Services Department, in Charleston, S.C.

  2. Implications of the Human Genome Project

    SciTech Connect

    Kitcher, P.

    1998-11-01

    The Human Genome Project (HGP), launched in 1991, aims to map and sequence the human genome by 2006. During the fifteen-year life of the project, it is projected that $3 billion in federal funds will be allocated to it. The ultimate aims of spending this money are to analyze the structure of human DNA, to identify all human genes, to recognize the functions of those genes, and to prepare for the biology and medicine of the twenty-first century. The following summary examines some of the implications of the program, concentrating on its scientific import and on the ethical and social problems that it raises. Its aim is to expose principles that might be used in applying the information which the HGP will generate. There is no attempt here to translate the principles into detailed proposals for legislation. Arguments and discussion can be found in the full report, but, like this summary, that report does not contain any legislative proposals.

  3. Projections from the 'cingular' vocalization area in the squirrel monkey.

    PubMed

    Müller-Preuss, P; Jürgens, U

    1976-02-13

    In 5 squirrel monkeys the anatomical projections from the 'cingular' vocalization area were studied by the autoradiographic tracing technique. The 'cingular' vocalization area lies around the sulcus cinguli at the level of the genu of the corpus callosum; its electrical stimulation yields purring and cackling calls. The following efferent connections were found: corticocortical fibers could be traced into the orbital cortex (areas 10 and 11), dorsomedial frontal cortex (areas 9, 8 and 6), limbic cortex (areas 25, 24 and 23), Broca's area (area 44), frontal operculum (area 50), insula (areas 13 and 14), and auditory association cortex (area 22). Subcortical terminal fields within the telencephalon were found in the nucleus caudatus, putamen, claustrum, globus pallidus, olfactory tubercle, preoptic region and nucleus centralis and basolateralis amygdalae. Fibers reached most of these structures along different trajectories. In the diencephalon terminal fields lay in the dorsal hypothalamus, the subthalamus, lateral habenular nucleus, and the following thalamic nuclei: nucleus reticularis, ventralis anterior, centralis medialis, centralis superior lateralis, centralis inferior, submedius, medialis dorsalis and centrum medianum. In the midbrain, the periaqueductal gray was the only projection area, extending into the parabrachial nuclei at the pontomesencephalic transition. The most caudal terminal field was found in the medial pontine gray. No terminals were detected in the nucleus ambiguus, nucleus n. hypoglossi or in any other cranial motor nucleus involved in phonation processes. A comparison of this projection system with the whole of structures producing vocalization when electrically stimulated yielded only partial overlap. Not all vocalization areas lie within the 'cingular' projection system, and inversely, not the whole projection system yielded vocalization. Overlap took place in the anterior limbic cortex, preoptic region, central amygdaloid nucleus

  4. Ashland Area Support Substation Project : Environmental Assessment.

    SciTech Connect

    United States. Bonneville Power Administration.

    1992-06-01

    The Bonneville Power Administration (BPA) provides wholesale electric service to the City of Ashland (the City) by transferring power over Pacific Power & Light Company`s (PP&L) 115-kilovolt (kV) transmission lines and through PP&L`s Ashland and Oak Knoll Substations. The City distributes power over a 12.5-kV system which is heavily loaded during winter peak periods and which has reached the limit of its ability to serve peak loads in a reliable manner. Peak loads under normal winter conditions have exceeded the ratings of the transformers at both the Ashland and Oak Knoll Substations. In 1989, the City modified its distribution system at the request of PP&L to allow transfer of three megawatts (MW`s) of electric power from the overloaded Ashland Substation to the Oak Knoll Substation. In cooperation with PP&L, BPA installed a temporary 6-8 megavolt-amp (MVA) 115-12.5-kV transformer for this purpose. This additional transformer, however, is only a temporary remedy. BPA needs to provide additional, reliable long-term service to the Ashland area through additional transformation in order to keep similar power failures from occurring during upcoming winters in the Ashland area. The temporary installation of another 20-MVA mobile transformer at the Ashland Substation and additional load curtailment are currently being studied to provide for sustained electrical service by the peak winter period 1992. Two overall electrical plans-of-service are described and evaluated in this report. One of them is proposed for action. Within that proposed plan-of-service are location options for the substation. Note that descriptions of actions that may be taken by the City of Ashland are based on information provided by them.

  5. Characterize Human Forward Contamination Project

    NASA Technical Reports Server (NTRS)

    Rucker, Michelle

    2015-01-01

    Let's face it: wherever we go, we will inevitably carry along the little critters that live in and on us. Conventional wisdom has long held that it's unlikely those critters could survive the space environment, but in 2007 microscopic animals called Tardigrades survived exposure to space and in 2008 Cyanobacteria lived for 548 days outside the International Space Station (ISS). But what about the organisms we might reasonably expect a crewed spacecraft to leak or vent? Do we even know what they are? How long might our tiny hitch-hikers survive in close proximity to a warm spacecraft that periodically leaks/vents water or oxygen-and how might they mutate with long-duration exposure? Unlike the Mars rovers that we cleaned once and sent on their way, crew members will provide a constantly regenerating contaminant source. Are we prepared to certify that we can meet forward contamination protocols as we search for life at new destinations? This project has four technical objectives: 1. TEST: Develop a test plan to leverage existing equipment (i.e. ISS) to characterize the kinds of organisms we can reasonably expect pressurized, crewed volumes to vent or leak overboard; 2. ANALYSIS: Develop an analysis plan to study those organisms in relevant destination environments, including spacecraft-induced conditions; 3. MODEL: Develop a modeling plan to model organism transport mechanisms in relevant destination environments; 4. SHARE: Develop a plan to disseminate findings and integrate recommendations into exploration requirements & ops. In short, we propose a system engineering approach to roadmap the necessary experiments, analysis, and modeling up front--rather than try to knit together disparate chunks of data into a sensible conclusion after the fact.

  6. Characterize Human Forward Contamination Project

    NASA Technical Reports Server (NTRS)

    Rucker, Michelle

    2015-01-01

    Let's face it: wherever we go, we will inevitably carry along the little critters that live in and on us. Conventional wisdom has long held that it's unlikely those critters could survive the space environment, but in 2007 microscopic animals called Tardigrades survived exposure to space and in 2008 Cyanobacteria lived for 548 days outside the International Space Station (ISS). But what about the organisms we might reasonably expect a crewed spacecraft to leak or vent? Do we even know what they are? How long might our tiny hitch-hikers survive in close proximity to a warm spacecraft that periodically leaks/vents water or oxygen-and how might they mutate with long-duration exposure? Unlike the Mars rovers that we cleaned once and sent on their way, crew members will provide a constantly regenerating contaminant source. Are we prepared to certify that we can meet forward contamination protocols as we search for life at new destinations? This project has four technical objectives: 1. TEST: Develop a test plan to leverage existing equipment (i.e. ISS) to characterize the kinds of organisms we can reasonably expect pressurized, crewed volumes to vent or leak overboard; as part of testing, we'll need to develop an Extravehicular Activity (EVA)-compatible tool that can withstand the pressure and temperature extremes of space, as well as collect, separate, and store multiple samples; 2. ANALYSIS: Develop an analysis plan to study those organisms in relevant destination environments, including spacecraft-induced conditions; 3. MODEL: Develop a modeling plan to model organism transport mechanisms in relevant destination environments; 4. SHARE: Develop a plan to disseminate findings and integrate recommendations into exploration requirements & ops. In short, we propose a system engineering approach to roadmap the necessary experiments, analysis, and modeling up front--rather than try to knit together disparate chunks of data into a sensible conclusion after the fact.

  7. First concept for a tropical area monitoring project

    NASA Technical Reports Server (NTRS)

    1976-01-01

    The first concept of a tropical area monitoring project is presented. The project would develop an operational system capable of monitoring land areas by machine processing of satellite data. LANDSAT images would be processed within a controlled isolable unit to detect changes in forest cover, rangeland, soil integrity, and other factors important to conservation of tropical ecology. An introductory developmental effort is described to demonstrate the use of LANDSAT data in this application. The independent unit, which functions as a user organization within the development project, assures that the technology will be transferable to a user organization through well defined, easily monitored interfaces with the rest of the world.

  8. Space Human Factors Engineering Gap Analysis Project Final Report

    NASA Technical Reports Server (NTRS)

    Hudy, Cynthia; Woolford, Barbara

    2006-01-01

    Humans perform critical functions throughout each phase of every space mission, beginning with the mission concept and continuing to post-mission analysis (Life Sciences Division, 1996). Space missions present humans with many challenges - the microgravity environment, relative isolation, and inherent dangers of the mission all present unique issues. As mission duration and distance from Earth increases, in-flight crew autonomy will increase along with increased complexity. As efforts for exploring the moon and Mars advance, there is a need for space human factors research and technology development to play a significant role in both on-orbit human-system interaction, as well as the development of mission requirements and needs before and after the mission. As part of the Space Human Factors Engineering (SHFE) Project within the Human Research Program (HRP), a six-month Gap Analysis Project (GAP) was funded to identify any human factors research gaps or knowledge needs. The overall aim of the project was to review the current state of human factors topic areas and requirements to determine what data, processes, or tools are needed to aid in the planning and development of future exploration missions, and also to prioritize proposals for future research and technology development.

  9. Daedalus Project's Light Eagle - Human powered aircraft

    NASA Technical Reports Server (NTRS)

    1987-01-01

    The Michelob Light Eagle is seen here in flight over Rogers Dry Lake at the NASA Dryden Flight Research Center, Edwards, California. The Light Eagle and Daedalus human powered aircraft were testbeds for flight research conducted at Dryden between January 1987 and March 1988. These unique aircraft were designed and constructed by a group of students, professors, and alumni of the Massachusetts Institute of Technology within the context of the Daedalus project. The construction of the Light Eagle and Daedalus aircraft was funded primarily by the Anheuser Busch and United Technologies Corporations, respectively, with additional support from the Smithsonian Air and Space Museum, MIT, and a number of other sponsors. To celebrate the Greek myth of Daedalus, the man who constructed wings of wax and feathers to escape King Minos, the Daedalus project began with the goal of designing, building and testing a human-powered aircraft that could fly the mythical distance, 115 km. To achieve this goal, three aircraft were constructed. The Light Eagle was the prototype aircraft, weighing 92 pounds. On January 22, 1987, it set a closed course distance record of 59 km, which still stands. Also in January of 1987, the Light Eagle was powered by Lois McCallin to set the straight distance, the distance around a closed circuit, and the duration world records for the female division in human powered vehicles. Following this success, two more aircraft were built, the Daedalus 87 and Daedalus 88. Each aircraft weighed approximately 69 pounds. The Daedalus 88 aircraft was the ship that flew the 199 km from the Iraklion Air Force Base on Crete in the Mediterranean Sea, to the island of Santorini in 3 hours, 54 minutes. In the process, the aircraft set new records in distance and endurance for a human powered aircraft. The specific areas of flight research conducted at Dryden included characterizing the rigid body and flexible dynamics of the Light Eagle, investigating sensors for an

  10. Think Big! The Human Condition Project

    ERIC Educational Resources Information Center

    Metcalfe, Gareth

    2014-01-01

    How can educators provide children with a genuine experience of carrying out an extended scientific investigation? And can teachers change the perception of what it means to be a scientist? These were key questions that lay behind "The Human Condition" project, an initiative funded by the Primary Science Teaching Trust to explore a new…

  11. The Human Genome Project and Biology Education.

    ERIC Educational Resources Information Center

    McInerney, Joseph D.

    1996-01-01

    Highlights the importance of the Human Genome Project in educating the public about genetics. Discusses four challenges that science educators must address: teaching for conceptual understanding, the nature of science, the personal and social impact of science and technology, and the principles of technology. Contains 45 references. (JRH)

  12. The Human Genome Project and eugenic concerns

    SciTech Connect

    Garver, K.L.; Garver, B. )

    1994-01-01

    The US Human Genome Project is the largest scientific project funded by the federal government since the Apollo Moon Project. The overall effect from this project should be of great benefit to humankind because it will provide a better understanding both of single gene defects and multifactorial or familial diseases such as diabetes, arteriosclerosis, and cancer. At first this will lead to more exact ways of screening and diagnosing genetic disease, and later it will lead, in many if not most instances, to specific genetic cures. However, in the past, in both the US and German eugenic movements genetic information has been misused. Hopefully, by remembering and understanding the past injustices and inhumanity of negative eugenics, further misuse of scientific information can be avoided. 142 refs.

  13. The Human Genome Project and eugenic concerns.

    PubMed

    Garver, K L; Garver, B

    1994-01-01

    The U.S. Human Genome project is the largest scientific project funded by the federal government since the Apollo Moon Project. The overall effect from this project should be of great benefit to humankind because it will provide a better understanding both of single gene defects and multifactorial or familial diseases such as diabetes, arteriosclerosis, and cancer. At first this will lead to more exact ways of screening and diagnosing genetic disease, and later it will lead, in many if not most instances, to specific genetic cures. However, in the past, in both the U.S. and German eugenic movements genetic information has been misused. Hopefully, by remembering and understanding the past injustices and inhumanity of negative eugenics, further misuse of scientific information can be avoided.

  14. The Human Genome Project and eugenic concerns.

    PubMed Central

    Garver, K. L.; Garver, B.

    1994-01-01

    The U.S. Human Genome project is the largest scientific project funded by the federal government since the Apollo Moon Project. The overall effect from this project should be of great benefit to humankind because it will provide a better understanding both of single gene defects and multifactorial or familial diseases such as diabetes, arteriosclerosis, and cancer. At first this will lead to more exact ways of screening and diagnosing genetic disease, and later it will lead, in many if not most instances, to specific genetic cures. However, in the past, in both the U.S. and German eugenic movements genetic information has been misused. Hopefully, by remembering and understanding the past injustices and inhumanity of negative eugenics, further misuse of scientific information can be avoided. PMID:8279465

  15. Space Mission Human Reliability Analysis (HRA) Project

    NASA Technical Reports Server (NTRS)

    Boyer, Roger

    2014-01-01

    The purpose of the Space Mission Human Reliability Analysis (HRA) Project is to extend current ground-based HRA risk prediction techniques to a long-duration, space-based tool. Ground-based HRA methodology has been shown to be a reasonable tool for short-duration space missions, such as Space Shuttle and lunar fly-bys. However, longer-duration deep-space missions, such as asteroid and Mars missions, will require the crew to be in space for as long as 400 to 900 day missions with periods of extended autonomy and self-sufficiency. Current indications show higher risk due to fatigue, physiological effects due to extended low gravity environments, and others, may impact HRA predictions. For this project, Safety & Mission Assurance (S&MA) will work with Human Health & Performance (HH&P) to establish what is currently used to assess human reliabiilty for human space programs, identify human performance factors that may be sensitive to long duration space flight, collect available historical data, and update current tools to account for performance shaping factors believed to be important to such missions. This effort will also contribute data to the Human Performance Data Repository and influence the Space Human Factors Engineering research risks and gaps (part of the HRP Program). An accurate risk predictor mitigates Loss of Crew (LOC) and Loss of Mission (LOM).The end result will be an updated HRA model that can effectively predict risk on long-duration missions.

  16. Projections of leaf area index in earth system models

    DOE PAGES

    Mahowald, Natalie; Lo, Fiona; Zheng, Yun; ...

    2016-03-09

    The area of leaves in the plant canopy, measured as leaf area index (LAI), modulates key land–atmosphere interactions, including the exchange of energy, moisture, carbon dioxide (CO2), and other trace gases and aerosols, and is therefore an essential variable in predicting terrestrial carbon, water, and energy fluxes. Here our goal is to characterize the LAI projections from the latest generation of earth system models (ESMs) for the Representative Concentration Pathway (RCP) 8.5 and RCP4.5 scenarios. On average, the models project increases in LAI in both RCP8.5 and RCP4.5 over most of the globe, but also show decreases in some partsmore » of the tropics. Because of projected increases in variability, there are also more frequent periods of low LAI across broad regions of the tropics. Projections of LAI changes varied greatly among models: some models project very modest changes, while others project large changes, usually increases. Modeled LAI typically increases with modeled warming in the high latitudes, but often decreases with increasing local warming in the tropics. The models with the most skill in simulating current LAI in the tropics relative to satellite observations tend to project smaller increases in LAI in the tropics in the future compared to the average of all the models. Using LAI projections to identify regions that may be vulnerable to climate change presents a slightly different picture than using precipitation projections, suggesting LAI may be an additional useful tool for understanding climate change impacts. Going forward, users of LAI projections from the CMIP5 ESMs evaluated here should be aware that model outputs do not exhibit clear-cut relationships to vegetation carbon and precipitation. Lastly, our findings underscore the need for more attention to LAI projections, in terms of understanding the drivers of projected changes and improvements to model skill.« less

  17. Projections of leaf area index in earth system models

    SciTech Connect

    Mahowald, Natalie; Lo, Fiona; Zheng, Yun; Harrison, Laura; Funk, Chris; Lombardozzi, Danica; Goodale, Christine

    2016-03-09

    The area of leaves in the plant canopy, measured as leaf area index (LAI), modulates key land–atmosphere interactions, including the exchange of energy, moisture, carbon dioxide (CO2), and other trace gases and aerosols, and is therefore an essential variable in predicting terrestrial carbon, water, and energy fluxes. Here our goal is to characterize the LAI projections from the latest generation of earth system models (ESMs) for the Representative Concentration Pathway (RCP) 8.5 and RCP4.5 scenarios. On average, the models project increases in LAI in both RCP8.5 and RCP4.5 over most of the globe, but also show decreases in some parts of the tropics. Because of projected increases in variability, there are also more frequent periods of low LAI across broad regions of the tropics. Projections of LAI changes varied greatly among models: some models project very modest changes, while others project large changes, usually increases. Modeled LAI typically increases with modeled warming in the high latitudes, but often decreases with increasing local warming in the tropics. The models with the most skill in simulating current LAI in the tropics relative to satellite observations tend to project smaller increases in LAI in the tropics in the future compared to the average of all the models. Using LAI projections to identify regions that may be vulnerable to climate change presents a slightly different picture than using precipitation projections, suggesting LAI may be an additional useful tool for understanding climate change impacts. Going forward, users of LAI projections from the CMIP5 ESMs evaluated here should be aware that model outputs do not exhibit clear-cut relationships to vegetation carbon and precipitation. Lastly, our findings underscore the need for more attention to LAI projections, in terms of understanding the drivers of projected changes and improvements to model skill.

  18. Human genome project and sickle cell disease.

    PubMed

    Norman, Brenda J; Miller, Sheila D

    2011-01-01

    Sickle cell disease is one of the most common genetic blood disorders in the United States that affects 1 in every 375 African Americans. Sickle cell disease is an inherited condition caused by abnormal hemoglobin in the red blood cells. The Human Genome Project has provided valuable insight and extensive research advances in the understanding of the human genome and sickle cell disease. Significant progress in genetic knowledge has led to an increase in the ability for researchers to map and sequence genes for diagnosis, treatment, and prevention of sickle cell disease and other chronic illnesses. This article explores some of the recent knowledge and advances about sickle cell disease and the Human Genome Project.

  19. Protected areas as frontiers for human migration.

    PubMed

    Zommers, Zinta; MacDonald, David W

    2012-06-01

    Causes of human population growth near protected areas have been much debated. We conducted 821 interviews in 16 villages around Budongo Forest Reserve, Masindi district, Uganda, to explore the causes of human migration to protected areas and to identify differences in forest use between migrant and nonmigrant communities. We asked subjects for information about birthplace, migration, household assets, household activities, and forest use. Interview subjects were categorized as nonmigrants (born in one of the interview villages), socioeconomic migrants (chose to emigrate for economic or social reasons) from within Masindi district (i.e., local migrants) and from outside the Masindi district (i.e., regional migrants), or forced migrants (i.e., refugees or internally displaced individuals who emigrated as a result of conflict, human rights abuses, or natural disaster). Only 198 respondents were born in interview villages, indicating high rates of migration between 1998 and 2008. Migrants were drawn to Budongo Forest because they thought land was available (268 individuals) or had family in the area (161 individuals). A greater number of regional migrants settled in villages near Lake Albert than did forced and local migrants. Migration category was also associated with differences in sources of livelihood. Of forced migrants 40.5% earned wages through labor, whereas 25.5% of local and 14.5% of regional migrants engaged in wage labor. Migrant groups appeared to have different effects on the environment. Of respondents that hunted, 72.7% were regional migrants. Principal component analyses indicated households of regional migrants were more likely to be associated with deforestation. Our results revealed gaps in current models of human population growth around protected areas. By highlighting the importance of social networks and livelihood choices, our results contribute to a more nuanced understanding of causes of migration and of the environmental effects of

  20. Human body surface area: a theoretical approach.

    PubMed

    Wang, Jianfeng; Hihara, Eiji

    2004-04-01

    Knowledge of the human body surface area has important applications in medical practice, garment design, and other engineering sizing. Therefore, it is not surprising that several expressions correlating body surface area with direct measurements of body mass and length have been reported in the literature. In the present study, based on the assumption that the exterior shape of the human body is the result of convex and concave deformations from a basic cylinder, we derive a theoretical equation minimizing body surface area (BSA) at a fixed volume (V): BSA=(9pi VL)(0.5), where L is the reference length of the body. Assuming a body density value of 1,000 kg.m(-3), the equation becomes BSA=(BM.BH/35.37)(0.5), where BSA is in square meters, BM is the body mass in kilograms, and BH is the body height in meters. BSA values calculated by means of this equation fall within +/-7% of the values obtained by means of the equations available in the literature, in the range of BSA from children to adults. It is also suggested that the above equation, which is obtained by minimizing the outer body surface at a fixed volume, implies a fundamental relation set by the geometrical constraints governing the growth and the development of the human body.

  1. McMinnville Area Support Transmission Project : Environmental Assessment.

    SciTech Connect

    United States. Bonneville Power Administration.

    1990-01-01

    This document discusses a project to provide continuing reliable electrical service to the McMinnville, Oregon, area. BPA proposes to participate with the City of McMinnville Water and Light Department in constructing a new 230-kilovolt transmission line and substation. BPA has prepared an environmental assessment evaluating the proposed project. Reasons that constructing the line and substation would not cause significant environmental impact include: consistency with local land use plans, consistency of appearance with existing transmission and manufacturing facilities in the area, only slight effect on farmland, and avoidance of wetlands and other environmentally sensitive areas. A finding is included that there is no practicable alternative to locating the project within a 100-year floodplain. 1 fig.

  2. ADP Analysis project for the Human Resources Management Division

    NASA Technical Reports Server (NTRS)

    Tureman, Robert L., Jr.

    1993-01-01

    The ADP (Automated Data Processing) Analysis Project was conducted for the Human Resources Management Division (HRMD) of NASA's Langley Research Center. The three major areas of work in the project were computer support, automated inventory analysis, and an ADP study for the Division. The goal of the computer support work was to determine automation needs of Division personnel and help them solve computing problems. The goal of automated inventory analysis was to find a way to analyze installed software and usage on a Macintosh. Finally, the ADP functional systems study for the Division was designed to assess future HRMD needs concerning ADP organization and activities.

  3. Human Genome Project and cystic fibrosis--a symbiotic relationship.

    PubMed

    Tolstoi, L G; Smith, C L

    1999-11-01

    When Watson and Crick determined the structure of DNA in 1953, a biological revolution began. One result of this revolution is the Human Genome Project. The primary goal of this international project is to obtain the complete nucleotide sequence of the human genome by the year 2005. Although molecular biologists and geneticists are most enthusiastic about the Human Genome Project, all areas of clinical medicine and fields of biology will be affected. Cystic fibrosis is the most common, inherited, lethal disease of white persons. In 1989, researchers located the cystic fibrosis gene on the long arm of chromosome 7 by a technique known as positional cloning. The most common mutation (a 3-base pair deletion) of the cystic fibrosis gene occurs in 70% of patients with cystic fibrosis. The knowledge gained from genetic research on cystic fibrosis will help researchers develop new therapies (e.g., gene) and improve standard therapies (e.g., pharmacologic) so that a patient's life span is increased and quality of life is improved. The purpose of this review is twofold. First, the article provides an overview of the Human Genome Project and its clinical significance in advancing interdisciplinary care for patients with cystic fibrosis. Second, the article includes a discussion of the genetic basis, pathophysiology, and management of cystic fibrosis.

  4. Human-Robot Interaction Directed Research Project

    NASA Technical Reports Server (NTRS)

    Rochlis, Jennifer; Ezer, Neta; Sandor, Aniko

    2011-01-01

    Human-robot interaction (HRI) is about understanding and shaping the interactions between humans and robots (Goodrich & Schultz, 2007). It is important to evaluate how the design of interfaces and command modalities affect the human s ability to perform tasks accurately, efficiently, and effectively (Crandall, Goodrich, Olsen Jr., & Nielsen, 2005) It is also critical to evaluate the effects of human-robot interfaces and command modalities on operator mental workload (Sheridan, 1992) and situation awareness (Endsley, Bolt , & Jones, 2003). By understanding the effects of interface design on human performance, workload, and situation awareness, interfaces can be developed that support the human in performing tasks with minimal errors and with appropriate interaction time and effort. Thus, the results of research on human-robot interfaces have direct implications for design. Because the factors associated with interfaces and command modalities in HRI are too numerous to address in 3 years of research, the proposed research concentrates on three manageable areas applicable to National Aeronautics and Space Administration (NASA) robot systems. These topic areas emerged from the Fiscal Year (FY) 2011 work that included extensive literature reviews and observations of NASA systems. The three topic areas are: 1) video overlays, 2) camera views, and 3) command modalities. Each area is described in detail below, along with relevance to existing NASA human-robot systems. In addition to studies in these three topic areas, a workshop is proposed for FY12. The workshop will bring together experts in human-robot interaction and robotics to discuss the state of the practice as applicable to research in space robotics. Studies proposed in the area of video overlays consider two factors in the implementation of augmented reality (AR) for operator displays during teleoperation. The first of these factors is the type of navigational guidance provided by AR symbology. In the proposed

  5. Underground Test Area Subproject Project Management Plan, Revision 1

    SciTech Connect

    1998-06-03

    This Project Management Plan (PMP) describes the manner in which the US Department of Energy Nevada Operations Office (DOE/NV) will manage the Underground Test Area (UGTA) Subproject at the Nevada Test Site (NTS). It provides the basic guidance for implementation and the organizational structure for meeting the UGTA objectives.

  6. 200 Area Deactivation Project Facilities Authorization Envelope Document

    SciTech Connect

    DODD, E.N.

    2000-03-28

    Project facilities as required by HNF-PRO-2701, Authorization Envelope and Authorization Agreement. The Authorization Agreements (AA's) do not identify the specific set of environmental safety and health requirements that are applicable to the facility. Therefore, the facility Authorization Envelopes are defined here to identify the applicable requirements. This document identifies the authorization envelopes for the 200 Area Deactivation.

  7. Nashville Area Employment and Training Needs. Vocational Education Exemplary Project.

    ERIC Educational Resources Information Center

    Nashville - Davidson County Metropolitan Public Schools, TN.

    A survey involving 1,142 Nashville, Tennessee, area businesses was conducted to assess current employment interest and future labor demands for entry-level jobs. Major objectives of the project component, part of a three-pronged effort to improve vocational education, were (1) to provide for greater involvement by business and industry in…

  8. Arts and Humanities: Perspectives. A First Report (1979) of Project H.E.L.P. (Humanities Education Liaison Program).

    ERIC Educational Resources Information Center

    Schwarz, Ira P., Comp.

    Project H.E.L.P. (Humanities Education Liaison Program) was initiated in 1976 to identify materials and programs in humanities and arts and to study various teaching methods. Investigation involved personal observations of the author, observations of area and state arts and humanities coordinators, and reports and observations by numerous teachers…

  9. Beyond the genomics blueprint: the 4th Human Variome Project Meeting, UNESCO, Paris, 2012.

    PubMed

    Kohonen-Corish, Maija R J; Smith, Timothy D; Robinson, Helen M

    2013-07-01

    The 4th Biennial Meeting of the Human Variome Project Consortium was held at the headquarters of the United Nations Educational, Scientific and Cultural Organization (UNESCO) in Paris, 11-15 June 2012. The Human Variome Project, a nongovernmental organization and an official partner of UNESCO, enables the routine collection, curation, interpretation, and sharing of information on all human genetic variation. This meeting was attended by more than 180 delegates from 39 countries and continued the theme of addressing issues of implementation in this unique project. The meeting was structured around the four main themes of the Human Variome Project strategic plan, "Project Roadmap 2012-2016": setting normative function, behaving ethically, sharing knowledge, and building capacity. During the meeting, the members held extensive discussions to formulate an action plan in the key areas of the Human Variome Project. The actions agreed on were promulgated at the Project's two Advisory Council and Scientific Advisory Committee postconference meetings.

  10. An overview of the human genome project

    SciTech Connect

    Batzer, M.A.

    1994-01-01

    The human genome project is one of the most ambitious scientific projects to date, with the ultimate goal being a nucleotide sequence for all four billion bases of human DNA. In the process of determining the nucleotide sequence for each base, the location, function, and regulatory regions from the estimated 100,000 human genes will be identified. The genome project itself relies upon maps of the human genetic code derived from several different levels of resolution. Genetic linkage analysis provides a low resolution genome map. The information for genetic linkage maps is derived from the analysis of chromosome specific markers such as Sequence Tagged Sites (STSs), Variable Number of Tandem Repeats (VNTRs) or other polymorphic (highly informative) loci in a number of different-families. Using this information the location of an unknown disease gene can be limited to a region comprised of one million base pairs of DNA or less. After this point, one must construct or have access to a physical map of the region of interest. Physical mapping involves the construction of an ordered overlapping (contiguous) set of recombinant DNA clones. These clones may be derived from a number of different vectors including cosmids, Bacterial Artificial Chromosomes (BACs), P1 derived Artificial Chromosomes (PACs), somatic cell hybrids, or Yeast Artificial Chromosomes (YACs). The ultimate goal for physical mapping is to establish a completely overlapping (contiguous) set of clones for the entire genome. After a gene or region of interest has been localized using physical mapping the nucleotide sequence is determined. The overlap between genetic mapping, physical mapping and DNA sequencing has proven to be a powerful tool for the isolation of disease genes through positional cloning.

  11. The Human Genome Project and biology education

    SciTech Connect

    McInerney, J.D.

    1995-12-01

    Within the last several years, biologists celebrated the fortieth anniversary of the Watson-Crick model of DNA and the fiftieth anniversary of the demonstration that DNA is the genetic material, discoveries that began a pervasive and ongoing revolution in biology and medicine. Nobelist Joshua Lederberg, for example, called the work of Avery`s group {open_quotes}the most important discovery in biology in the twentieth century.{close_quotes} This early work on DNA also contributed to a revolution in biology education, beginning in the 1960s. Like the biological revolution that is its counterpart, however, the educational revolution is incomplete, in part because the science continues to evolve, but primarily because scientists and science educators have not yet responded completely to the challenges of genetics and molecular biology. These challenges are made even more obvious by the scope and visibility of the Human Genome Project, the international project intended to map and sequence all human genes. Science educators face 4 challenges discussed in this article and using the Genome project as an example: teach for conceptual understanding; the nature of science; the personal and social impact of science and technology; the principles of technology.

  12. Origins of the Human Genome Project

    SciTech Connect

    Cook-Deegan, Robert

    1993-07-01

    The human genome project was borne of technology, grew into a science bureaucracy in the US and throughout the world, and is now being transformed into a hybrid academic and commercial enterprise. The next phase of the project promises to veer more sharply toward commercial application, harnessing both the technical prowess of molecular biology and the rapidly growing body of knowledge about DNA structure to the pursuit of practical benefits. Faith that the systematic analysis of DNA structure will prove to be a powerful research tool underlies the rationale behind the genome project. The notion that most genetic information is embedded in the sequence of CNA base pairs comprising chromosomes is a central tenet. A rough analogy is to liken an organism's genetic code to computer code. The coal of the genome project, in this parlance, is to identify and catalog 75,000 or more files (genes) in the software that directs construction of a self-modifying and self-replicating system -- a living organism.

  13. Origins of the Human Genome Project

    DOE R&D Accomplishments Database

    Cook-Deegan, Robert (Affiliation: Institute of Medicine, National Academy of Sciences)

    1993-07-01

    The human genome project was borne of technology, grew into a science bureaucracy in the United States and throughout the world, and is now being transformed into a hybrid academic and commercial enterprise. The next phase of the project promises to veer more sharply toward commercial application, harnessing both the technical prowess of molecular biology and the rapidly growing body of knowledge about DNA structure to the pursuit of practical benefits. Faith that the systematic analysis of DNA structure will prove to be a powerful research tool underlies the rationale behind the genome project. The notion that most genetic information is embedded in the sequence of CNA base pairs comprising chromosomes is a central tenet. A rough analogy is to liken an organism's genetic code to computer code. The coal of the genome project, in this parlance, is to identify and catalog 75,000 or more files (genes) in the software that directs construction of a self-modifying and self-replicating system -- a living organism.

  14. Project ATHENA Creates Surrogate Human Organ Systems

    SciTech Connect

    MacQueen, Luke; Knospel, Fanny; Sherrod, Stacy; Iyer, Rashi

    2015-06-15

    The development of miniature surrogate human organs, coupled with highly sensitive mass spectrometry technologies, could one day revolutionize the way new drugs and toxic agents are studied. “By developing this ‘homo minutus,’ we are stepping beyond the need for animal or Petri dish testing: There are huge benefits in developing drug and toxicity analysis systems that can mimic the response of actual human organs,” said Rashi Iyer, a senior scientist at Los Alamos National Laboratory. ATHENA, the Advanced Tissue-engineered Human Ectypal Network Analyzer project team, is nearing the full integration of four human organ constructs — liver, heart, lung and kidney — each organ component is about the size of a smartphone screen, and the whole ATHENA “body” of interconnected organs will fit neatly on a desk. A new video available on the Los Alamos National Laboratory YouTube channel updates the ATHENA project as it begins to integrate the various organ systems into a single system (link to video here). Some 40 percent of pharmaceuticals fail their clinical trials and there are thousands of chemicals whose effects on humans are simply unknown. Providing a realistic, cost-effective and rapid screening system such as ATHENA with high-throughput capabilities could provide major benefits to the medical field, screening more accurately and offering a greater chance of clinical trial success. ATHENA is funded by the Defense Threat Reduction Agency (DTRA) and is a collaboration of Los Alamos National Laboratory, Harvard University, Vanderbilt University, Charité Universitätsmedizin, Berlin, Germany, CFD Research Corporation, and the University of California San Francisco.

  15. Project ATHENA Creates Surrogate Human Organ Systems

    ScienceCinema

    MacQueen, Luke; Knospel, Fanny; Sherrod, Stacy; Iyer, Rashi

    2016-07-12

    The development of miniature surrogate human organs, coupled with highly sensitive mass spectrometry technologies, could one day revolutionize the way new drugs and toxic agents are studied. “By developing this ‘homo minutus,’ we are stepping beyond the need for animal or Petri dish testing: There are huge benefits in developing drug and toxicity analysis systems that can mimic the response of actual human organs,” said Rashi Iyer, a senior scientist at Los Alamos National Laboratory. ATHENA, the Advanced Tissue-engineered Human Ectypal Network Analyzer project team, is nearing the full integration of four human organ constructs — liver, heart, lung and kidney — each organ component is about the size of a smartphone screen, and the whole ATHENA “body” of interconnected organs will fit neatly on a desk. A new video available on the Los Alamos National Laboratory YouTube channel updates the ATHENA project as it begins to integrate the various organ systems into a single system (link to video here). Some 40 percent of pharmaceuticals fail their clinical trials and there are thousands of chemicals whose effects on humans are simply unknown. Providing a realistic, cost-effective and rapid screening system such as ATHENA with high-throughput capabilities could provide major benefits to the medical field, screening more accurately and offering a greater chance of clinical trial success. ATHENA is funded by the Defense Threat Reduction Agency (DTRA) and is a collaboration of Los Alamos National Laboratory, Harvard University, Vanderbilt University, Charité Universitätsmedizin, Berlin, Germany, CFD Research Corporation, and the University of California San Francisco.

  16. [Human genome project: a federator program of genomic medicine].

    PubMed

    Sfar, S; Chouchane, L

    2008-05-01

    The Human Genome Project improves our understanding of the molecular genetics basis of the inherited and complex diseases such as diabetes, schizophrenia, and cancer. Information from the human genome sequence is essential for several antenatal and neonatal screening programmes. The new genomic tools emerging from this project have revolutionized biology and medicine and have transformed our understanding of health and the provision of healthcare. Its implications pervade all areas of medicine, from disease prediction and prevention to the diagnosis and treatment of all forms of disease. Increasingly, it will be possible to drive predisposition testing into clinical practice, to develop new treatments or to adapt available treatments more specifically to an individual's genetic make-up. This genomic information should transform the traditional medications that are effective for every members of the population to personalized medicine and personalized therapy. The pharmacogenomics could give rise to a new generation of highly effective drugs that treat causes, not just symptoms.

  17. The Human Brain Project and neuromorphic computing

    PubMed Central

    Calimera, Andrea; Macii, Enrico; Poncino, Massimo

    Summary Understanding how the brain manages billions of processing units connected via kilometers of fibers and trillions of synapses, while consuming a few tens of Watts could provide the key to a completely new category of hardware (neuromorphic computing systems). In order to achieve this, a paradigm shift for computing as a whole is needed, which will see it moving away from current “bit precise” computing models and towards new techniques that exploit the stochastic behavior of simple, reliable, very fast, low-power computing devices embedded in intensely recursive architectures. In this paper we summarize how these objectives will be pursued in the Human Brain Project. PMID:24139655

  18. The Genome Project and human health

    SciTech Connect

    Collins, F.S. )

    1991-01-01

    The author claims that the positional cloning approach, whereby a gene is identified by its map position without making assumptions about its structure or function, has provided significant information about common inherited disorders. Genes responsible for cystic fibrosis, Duchenne muscular dystrophy, and neurofibromatosis have been cloned. However, this technology has been labor intensive and extremely expensive. The Human Genome Project will provide information that will drive research for at least the next 100 years and will likely transform medicine in the 21st century into the preventive mode.

  19. Justice and the Human Genome Project

    SciTech Connect

    Murphy, T.F.; Lappe, M.

    1992-12-31

    Most of the essays gathered in this volume were first presented at a conference, Justice and the Human Genome, in Chicago in early November, 1991. The goal of the, conference was to consider questions of justice as they are and will be raised by the Human Genome Project. To achieve its goal of identifying and elucidating the challenges of justice inherent in genomic research and its social applications the conference drew together in one forum members from academia, medicine, and industry with interests divergent as rate-setting for insurance, the care of newborns, and the history of ethics. The essays in this volume address a number of theoretical and practical concerns relative to the meaning of genomic research.

  20. Justice and the Human Genome Project

    SciTech Connect

    Murphy, T.F.; Lappe, M.

    1992-01-01

    Most of the essays gathered in this volume were first presented at a conference, Justice and the Human Genome, in Chicago in early November, 1991. The goal of the, conference was to consider questions of justice as they are and will be raised by the Human Genome Project. To achieve its goal of identifying and elucidating the challenges of justice inherent in genomic research and its social applications the conference drew together in one forum members from academia, medicine, and industry with interests divergent as rate-setting for insurance, the care of newborns, and the history of ethics. The essays in this volume address a number of theoretical and practical concerns relative to the meaning of genomic research.

  1. The Human Genome Diversity Project: past, present and future.

    PubMed

    Cavalli-Sforza, L Luca

    2005-04-01

    The Human Genome Project, in accomplishing its goal of sequencing one human genome, heralded a new era of research, a component of which is the systematic study of human genetic variation. Despite delays, the Human Genome Diversity Project has started to make progress in understanding the patterns of this variation and its causes, and also promises to provide important information for biomedical studies.

  2. The human genome project and international health

    SciTech Connect

    Watson, J.D.; Cook-Deegan, R.M. )

    1990-06-27

    The human genome project is designed to provide common resources for the study of human genetics, and to assist biomedical researchers in their assault on disease. The main benefit will be to provide several kinds of maps of the human genome, and those of other organisms, to permit rapid isolation of genes for further study about DNA structure and function. This article describes genome research programs in developed and developing countries, and the international efforts that have contributed to genome research programs. For example, the large-scale collaborations to study Duchenne's muscular dystrophy, Huntington's disease, Alzheimer's disease, cystic fibrosis involve collaborators from many nations and families spread throughout the world. In the USA, the US Department of Energy was first to start a dedicated genome research program in 1987. Since then, another major government program has begun at the National Center for Human Genome Research of the National Institutes of Health. Italy, China, Australia, France, Canada, and Japan have genome research programs also.

  3. Freihoelser Forst Local Training Area rehabilitation project. Final report

    SciTech Connect

    Hinchman, R.R.; Zellmer, S.D.; Johnson, D.O.; Severinghaus, W.D.; Brent, J.J.

    1991-12-01

    Intensive and continued use of the Freihoelser Forst Local Training Area (LTA) for military training activities had resulted in serious environmental problems, exemplified by a lack of vegetative cover and severe erosion by water and wind. The project`s goal was to develop and demonstrate rapid, cost-effective methods to stabilize the LTA`s barren, eroding maneuver areas and make training conditions more realistic. The major factors limiting rehabilitation efforts were the sandy, infertile, and acidic soils. The project was conducted in two phases. Phase I demonstrated and evaluated three separate rehabilitation treatments ranging in cost from moderate to expensive. Each treatment used a different type of soil amendment (fertilizer and straw, compost, or chicken manure), but all used identical seedbed preparation methods and seed mixtures. Phase I was conducted on relatively small replicated plots and was monitored three times during each growing season. All three treatments satisfactorily reestablished vegetation and controlled erosion. Because of their small size, the Phase I demonstration plots had only a minor stabilizing effect on the erosion problems of the LTA as a whole. The Phase II treatment was based on lessons teamed from Phase I and from other revegetation projects in Germany. Phase II revegetated a large area of the LTA, which included nearly all of the most severely disturbed land. Phase II, which was monitored in the same way as Phase I but for a shorter period of time, was highly successful in stabilizing most areas treated. The revegetation plant community was dominated by native grasses and legumes that stabilized the loose, sandy soils and improved the training realism of a major portion of the LTA.

  4. Human Factors Considerations for Area Navigation Departure and Arrival Procedures

    NASA Technical Reports Server (NTRS)

    Barhydt, Richard; Adams, Catherine A.

    2006-01-01

    Area navigation (RNAV) procedures are being implemented in the United States and around the world as part of a transition to a performance-based navigation system. These procedures are providing significant benefits and have also caused some human factors issues to emerge. Under sponsorship from the Federal Aviation Administration (FAA), the National Aeronautics and Space Administration (NASA) has undertaken a project to document RNAV-related human factors issues and propose areas for further consideration. The component focusing on RNAV Departure and Arrival Procedures involved discussions with expert users, a literature review, and a focused review of the NASA Aviation Safety Reporting System (ASRS) database. Issues were found to include aspects of air traffic control and airline procedures, aircraft systems, and procedure design. Major findings suggest the need for specific instrument procedure design guidelines that consider the effects of human performance. Ongoing industry and government activities to address air-ground communication terminology, design improvements, and chart-database commonality are strongly encouraged. A review of factors contributing to RNAV in-service errors would likely lead to improved system design and operational performance.

  5. Vestibular projections in the human cortex.

    PubMed

    de Waele, C; Baudonnière, P M; Lepecq, J C; Tran Ba Huy, P; Vidal, P P

    2001-12-01

    There is considerable evidence from studies on cats and monkeys that several cortical areas such as area 2v at the tip of the intraparietal sulcus, area 3av in the sulcus centralis, the parietoinsular vestibular cortex adjacent to the posterior insula (PIVC) and area 7 in the inferior parietal lobule are involved in the processing of vestibular information. Microelectrode recordings from these areas have shown that: (1) most of these cortical neurons are connected trisynaptically to the labyrinthine endorgans and (2) they receive converging vestibular, visual and somatosensory inputs. These data suggest that a multimodal cortical system is involved in postural and gaze control. In humans, recent positron emission tomography (PET) scans and functional magnetic resonance imaging (fMRI) studies have largely confirmed these data. However, because of the limited temporal resolution of these two methods, the minimum time of arrival of labyrinthine inputs from the vestibular hair cells to these cortical areas has not yet been determined. In this study, we used the evoked potential method to attempt to answer this question. Due to its excellent temporal resolution, this method is ideal for the investigation of the tri- or polysynaptic nature of the vestibulocortical pathways. Eleven volunteer patients, who underwent a vestibular neurectomy due to intractable Meniere's disease (MD) or acoustic neurinoma resection, were included in this experiment. Patients were anesthetized and the vestibular nerve was electrically stimulated. The evoked potentials were recorded by 30 subcutaneous active electrodes located on the scalp. The brain electrical source imaging (BESA) program (version 2.0, 1995) was used to calculate dipole sources. The latency period for the activation of five distinct cortical zones, including the prefrontal and/or the frontal lobe, the ipsilateral temporoparietal cortex, the anterior portion of the supplementary motor area (SMA) and the contralateral parietal

  6. Area recommendation report for the crystalline repository project: An evaluation. [Crystalline Repository Project

    SciTech Connect

    Beck, J E; Lowe, H; Yurkovich, S P

    1986-03-28

    An evaluation is given of DOE's recommendation of the Elk River complex in North Carolina for siting the second repository. Twelve recommendations are made including a strong suggestion that the Cherokee Tribe appeal both through political and legal avenues for inclusion as an affected area primarily due to projected impacts upon economy and public health as a consequence of the potential for reduced tourism.

  7. Ground-water resources of Riverton irrigation project area, Wyoming

    USGS Publications Warehouse

    Morris, Donald Arthur; Hackett, O.M.; Vanlier, K.E.; Moulder, E.A.; Durum, W.H.

    1959-01-01

    The Riverton irrigation project area is in the northwestern part of the Wind River basin in west-central Wyoming. Because the annual precipitation is only about 9 inches, agriculture, which is the principal occupation in the area, is dependent upon irrigation. Irrigation by surface-water diversion was begum is 1906; water is now supplied to 77,716 acres and irrigation has been proposed for an additional 31,344 acres. This study of the geology and ground-water resources of the Riverton irrigation project, of adjacent irrigated land, and of nearby land proposed for irrigation was begun during the summer of 1948 and was completed in 1951. The purpose of the investigation was to evaluate the ground-water resources of the area and to study the factors that should be considered in the solution of drainage and erosional problems within the area. The Riverton irrigation project area is characterized by flat to gently sloping stream terraces, which are flanked by a combination of badlands, pediment slopes, and broad valleys. These features were formed by long-continued erosion in an arid climate of the essentially horizontal, poorly consolidated beds of the Wind River formation. The principal streams of the area flow south-eastward. Wind River and Fivemile Creek are perennial streams and the others are intermittent. Ground-water discharge and irrigation return flow have created a major problem in erosion control along Fivemile Creek. Similar conditions might develop along Muddy and lower Cottonwood Creeks when land in their drainage basins is irrigated. The bedrock exposed in the area ranges in age from Late Cretaceous to early Tertiary (middle Eocene). The Wind River formation of early and middle Eocene age forms the uppermost bedrock formation in the greater part of the area. Unconsolidated deposits of Quaternary age, which consist of terrace gravel, colluvium, eolian sand and silt. and alluvium, mantle the Wind River formation in much of the area. In the irrigated parts

  8. Safe drinking water projects integrated information system for rural areas

    NASA Astrophysics Data System (ADS)

    Song, Xue-ling; Zhao, Ying-bao; Liu, Chao-ying; Song, Zhe-ying

    2009-07-01

    According to the water supply characteristics in rural areas, it designs a safe drinking water project in this paper. The whole system includes three parts. Those are communication part, automatic control and test part and video surveillance part. Communication part mainly realizes the data transfer between PLC controlled equipment, branch pipeline monitoring and control equipment in the water plant. Automatic control and test part adopts hierarchical, distributed, decentralized structure to remote control and dynamic detect the data on-site. Video Surveillance part can monitor the personnel and equipment condition to guarantee the safe of the whole system. The system takes Visual Studio .NET as the development platform and it entirely bases on the public network B/S structure. From the application, it can be seen that the whole system has the characters of using and maintaining easily, interface simple and friend and it can improve the drinking water condition in rural areas greatly.

  9. Project Management Methodology in Human Resource Management

    ERIC Educational Resources Information Center

    Josler, Cheryl; Burger, James

    2005-01-01

    When charged with overseeing a project, how can one ensure that the project will be completed on time, within budget, and to the satisfaction of everyone involved? In this article, the authors examine project management methodology as a means of ensuring that projects are conducted in a disciplined, well-managed and consistent manner that serves…

  10. The UK Human Genome Mapping Project online computing service.

    PubMed

    Rysavy, F R; Bishop, M J; Gibbs, G P; Williams, G W

    1992-04-01

    This paper presents an overview of computing and networking facilities developed by the Medical Research Council to provide online computing support to the Human Genome Mapping Project (HGMP) in the UK. The facility is connected to a number of other computing facilities in various centres of genetics and molecular biology research excellence, either directly via high-speed links or through national and international wide-area networks. The paper describes the design and implementation of the current system, a 'client/server' network of Sun, IBM, DEC and Apple servers, gateways and workstations. A short outline of online computing services currently delivered by this system to the UK human genetics research community is also provided. More information about the services and their availability could be obtained by a direct approach to the UK HGMP-RC.

  11. The Griffith area palliative care service: a pilot project.

    PubMed

    Hatton, Ian; McDonald, Keith; Nancarrow, Lynette; Fletcher, Keith

    2003-01-01

    In September 2000 the Commonwealth released, as part of its National Palliative Care Strategy under the Australian Health Care Agreements, a National Framework for Palliative Care Service Development. The new National Framework stressed an important set of values to guide models of palliative care delivery. It notes that the challenge is to secure the place of palliative care as an integral part of health care across Australia, routinely available within local communities to those people who need it. Care and support for people who are dying and their families need to be built not only into health care services, but also into the fabric of communities and their support networks. While few would disagree with this, little is known about how best to achieve it in rural Australia. The Griffith Area Palliative Care Service (GAPS) is a two-year pilot project delivering a palliative care service through a truly integrated approach to care for patients, their carers and families within the Griffith Local Government Area and Carrathool Shire areas. This paper describes how GAPS is successfully meeting the challenges of service provision to rural and remote areas.

  12. Minimal Technologies Application Project, Hohenfels Training Area, Germany: Final report

    SciTech Connect

    Zellmer, S.D.; Hinchman, R.R.; Johnson, D.O. . Energy Systems Div.); Severinghaus, W.D. ); Brent, J.J. )

    1991-12-01

    At the US Army Hohenfels Training Area in Germany, more than 30 years of continuous and intensive tactical training has caused extensive environmental damage because of the loss of vegetative cover and accelerated soil erosion. A project was conducted to evaluate the cost-effectiveness and relative benefits of various revegetation procedures. These procedures involved amendment and seedbed preparation options that were combined with three different durations of site closure. The point-intercept method was used to measure the types and amounts of vegetation established and changes in the vegetative community. Over three growing seasons, applications of fertilizer and seed increased the percent grass, legume, and total vegetative cover. The duration of site closure had no influence on the types or amounts of ground cover established. Materials made up only 10% of the total cost of the fertilization and seeding operations. The results of the research indicate that less expensive methods of amendment application should be evaluated. The data also show that site closure is not practical, economical, or necessary. The results of this project suggest that a regular maintenance program consisting of seeding and fertilization is required to maintain adequate vegetative cover and control erosion on tactical training areas.

  13. The Human Genome Project: An Imperative for International Collaboration.

    ERIC Educational Resources Information Center

    Allende, J. E.

    1989-01-01

    Discussed is the Human Genome Project which aims to decipher the totality of the human genetic information. The historical background, the objectives, international cooperation, ethical discussion, and the role of UNESCO are included. (KR)

  14. Societal and medical consequences of the Human Genome Project. Inter-disciplinary approaches to human genetics.

    PubMed

    Keilbart, M

    2000-09-01

    The Human Genome Project is a US-based molecular biological project, the results of which are likely to be implemented on humans. The sociopolitical dimension of this is highly neglected. The aim of the conference was to fill this gap by drawing together scientists of natural and political sciences to discuss the consequences of the Human Genome Project across the disciplines.

  15. Projections from the Subfornical Region of the Lateral Hypothalamic Area

    PubMed Central

    GOTO, MARINA; CANTERAS, NEWTON S.; BURNS, GULLY; SWANSON, LARRY W.

    2010-01-01

    The L-shaped anterior zone of the lateral hypothalamic area’s subfornical region (LHAsfa) is delineated by a pontine nucleus incertus input. Function evidence suggests the subfornical region and nucleus incertus modulate foraging and defensive behaviors, although subfornical region connections are poorly understood. A high resolution Phaseolus vulgaris-leucoagglutinin (PHAL) structural analysis is presented here of the LHAsfa neuron population’s overall axonal projection pattern. The strongest LHAsfa targets are in the interbrain and cerebral hemisphere. The former include inputs to anterior hypothalamic nucleus, dorsomedial part of the ventromedial nucleus, and ventral region of the dorsal premammillary nucleus (defensive behavior control system components), and to lateral habenula and dorsal region of the dorsal premammillary nucleus (foraging behavior control system components). The latter include massive inputs to lateral and medial septal nuclei (septo-hippocampal system components), and inputs to bed nuclei of the stria terminalis posterior division related to the defensive behavior system, intercalated amygdalar nucleus (projecting to central amygdalar nucleus), and posterior part of the basomedial amygdalar nucleus. LHAsfa vertical and horizontal limb basic projection patterns are similar, although each preferentially innervates certain terminal fields. Lateral hypothalamic area regions immediately medial, lateral, and caudal to the LHAsfa each generate quite distinct projection patterns. Combined with previous evidence that major sources LHAsfa neural inputs include the parabrachial nucleus (nociceptive information), defensive and foraging behavior system components, and the septo-hippocampal system, the present results suggest that the LHAsfa helps match adaptive behavioral responses (either defensive or foraging) to current internal motivational status and external environmental conditions. PMID:16261534

  16. Human-Robot Interaction Directed Research Project

    NASA Technical Reports Server (NTRS)

    Sandor, Aniko; Cross, Ernest V., II; Chang, M. L.

    2014-01-01

    Human-robot interaction (HRI) is a discipline investigating the factors affecting the interactions between humans and robots. It is important to evaluate how the design of interfaces and command modalities affect the human's ability to perform tasks accurately, efficiently, and effectively when working with a robot. By understanding the effects of interface design on human performance, workload, and situation awareness, interfaces can be developed to appropriately support the human in performing tasks with minimal errors and with appropriate interaction time and effort. Thus, the results of research on human-robot interfaces have direct implications for the design of robotic systems. This DRP concentrates on three areas associated with interfaces and command modalities in HRI which are applicable to NASA robot systems: 1) Video Overlays, 2) Camera Views, and 3) Command Modalities. The first study focused on video overlays that investigated how Augmented Reality (AR) symbology can be added to the human-robot interface to improve teleoperation performance. Three types of AR symbology were explored in this study, command guidance (CG), situation guidance (SG), and both (SCG). CG symbology gives operators explicit instructions on what commands to input, whereas SG symbology gives operators implicit cues so that operators can infer the input commands. The combination of CG and SG provided operators with explicit and implicit cues allowing the operator to choose which symbology to utilize. The objective of the study was to understand how AR symbology affects the human operator's ability to align a robot arm to a target using a flight stick and the ability to allocate attention between the symbology and external views of the world. The study evaluated the effects type of symbology (CG and SG) has on operator tasks performance and attention allocation during teleoperation of a robot arm. The second study expanded on the first study by evaluating the effects of the type of

  17. Robust human detection, tracking, and recognition in crowded urban areas

    NASA Astrophysics Data System (ADS)

    Chen, Hai-Wen; McGurr, Mike

    2014-06-01

    In this paper, we present algorithms we recently developed to support an automated security surveillance system for very crowded urban areas. In our approach for human detection, the color features are obtained by taking the difference of R, G, B spectrum and converting R, G, B to HSV (Hue, Saturation, Value) space. Morphological patch filtering and regional minimum and maximum segmentation on the extracted features are applied for target detection. The human tracking process approach includes: 1) Color and intensity feature matching track candidate selection; 2) Separate three parallel trackers for color, bright (above mean intensity), and dim (below mean intensity) detections, respectively; 3) Adaptive track gate size selection for reducing false tracking probability; and 4) Forward position prediction based on previous moving speed and direction for continuing tracking even when detections are missed from frame to frame. The Human target recognition is improved with a Super-Resolution Image Enhancement (SRIE) process. This process can improve target resolution by 3-5 times and can simultaneously process many targets that are tracked. Our approach can project tracks from one camera to another camera with a different perspective viewing angle to obtain additional biometric features from different perspective angles, and to continue tracking the same person from the 2nd camera even though the person moved out of the Field of View (FOV) of the 1st camera with `Tracking Relay'. Finally, the multiple cameras at different view poses have been geo-rectified to nadir view plane and geo-registered with Google- Earth (or other GIS) to obtain accurate positions (latitude, longitude, and altitude) of the tracked human for pin-point targeting and for a large area total human motion activity top-view. Preliminary tests of our algorithms indicate than high probability of detection can be achieved for both moving and stationary humans. Our algorithms can simultaneously track

  18. Human-Robot Interaction Directed Research Project

    NASA Technical Reports Server (NTRS)

    Sandor, Aniko; Cross, Ernest V., II; Chang, Mai Lee

    2014-01-01

    Human-robot interaction (HRI) is a discipline investigating the factors affecting the interactions between humans and robots. It is important to evaluate how the design of interfaces and command modalities affect the human's ability to perform tasks accurately, efficiently, and effectively when working with a robot. By understanding the effects of interface design on human performance, workload, and situation awareness, interfaces can be developed to appropriately support the human in performing tasks with minimal errors and with appropriate interaction time and effort. Thus, the results of research on human-robot interfaces have direct implications for the design of robotic systems. This DRP concentrates on three areas associated with interfaces and command modalities in HRI which are applicable to NASA robot systems: 1) Video Overlays, 2) Camera Views, and 3) Command Modalities. The first study focused on video overlays that investigated how Augmented Reality (AR) symbology can be added to the human-robot interface to improve teleoperation performance. Three types of AR symbology were explored in this study, command guidance (CG), situation guidance (SG), and both (SCG). CG symbology gives operators explicit instructions on what commands to input, whereas SG symbology gives operators implicit cues so that operators can infer the input commands. The combination of CG and SG provided operators with explicit and implicit cues allowing the operator to choose which symbology to utilize. The objective of the study was to understand how AR symbology affects the human operator's ability to align a robot arm to a target using a flight stick and the ability to allocate attention between the symbology and external views of the world. The study evaluated the effects type of symbology (CG and SG) has on operator tasks performance and attention allocation during teleoperation of a robot arm. The second study expanded on the first study by evaluating the effects of the type of

  19. The Perseus Project and Beyond: How Building a Digital Library Challenges the Humanities and Technology.

    ERIC Educational Resources Information Center

    Crane, Gregory

    1998-01-01

    The Perseus Project, a digital library in the humanities concentrating on ancient Greek culture, is expanding to cover Roman, Renaissance and various other areas of the humanities. Goals include helping traditional scholars research effectively and help humanists use technology to redefine the relationship between their work and the broader…

  20. Standard development at the Human Variome Project.

    PubMed

    Smith, Timothy D; Vihinen, Mauno

    2015-01-01

    The Human Variome Project (HVP) is a world organization working towards facilitating the collection, curation, interpretation and free and open sharing of genetic variation information. A key component of HVP activities is the development of standards and guidelines. HVP Standards are systems, procedures and technologies that the HVP Consortium has determined must be used by HVP-affiliated data sharing infrastructure and should be used by the broader community. HVP guidelines are considered to be beneficial for HVP affiliated data sharing infrastructure and the broader community to adopt. The HVP also maintains a process for assessing systems, processes and tools that implement HVP Standards and Guidelines. Recommended System Status is an accreditation process designed to encourage the adoption of HVP Standards and Guidelines. Here, we describe the HVP standards development process and discuss the accepted standards, guidelines and recommended systems as well as those under acceptance. Certain HVP Standards and Guidelines are already widely adopted by the community and there are committed users for the others.

  1. 77 FR 5489 - Identification of Human Cell Lines Project

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-03

    ... National Institute of Standards and Technology Identification of Human Cell Lines Project AGENCY: National... tandem repeat (STR) profiling up to 1500 human cell line samples as part of the Identification of Human... its intent to unambiguously identify by short tandem repeat (STR) profiling up to 1500 human cell...

  2. Advanced Large Area Plastic Scintillator Project (ALPS): Final Report

    SciTech Connect

    Jordan, David V.; Reeder, Paul L.; Todd, Lindsay C.; Warren, Glen A.; McCormick, Kathleen R.; Stephens, Daniel L.; Geelhood, Bruce D.; Alzheimer, James M.; Crowell, Shannon L.; Sliger, William A.

    2008-02-05

    The advanced Large-Area Plastic Scintillator (ALPS) Project at Pacific Northwest National Laboratory investigated possible technological avenues for substantially advancing the state-of-the-art in gamma-ray detection via large-area plastic scintillators. The three predominant themes of these investigations comprised the following: * Maximizing light collection efficiency from a single large-area sheet of plastic scintillator, and optimizing hardware event trigger definition to retain detection efficiency while exploiting the power of coincidence to suppress single-PMT "dark current" background; * Utilizing anti-Compton vetoing and supplementary spectral information from a co-located secondary, or "Back" detector, to both (1) minimize Compton background in the low-energy portion of the "Front" scintillator's pulse-height spectrum, and (2) sharpen the statistical accuracy of the front detector's low-energy response prediction as impelmented in suitable energy-windowing algorithms; and * Investigating alternative materials to enhance the intrinsic gamma-ray detection efficiency of plastic-based sensors.

  3. Encoding of Human Action in Broca's Area

    ERIC Educational Resources Information Center

    Fazio, Patrik; Cantagallo, Anna; Craighero, Laila; D'Ausilio, Alessandro; Roy, Alice C.; Pozzo, Thierry; Calzolari, Ferdinando; Granieri, Enrico; Fadiga, Luciano

    2009-01-01

    Broca's area has been considered, for over a century, as the brain centre responsible for speech production. Modern neuroimaging and neuropsychological evidence have suggested a wider functional role is played by this area. In addition to the evidence that it is involved in syntactical analysis, mathematical calculation and music processing, it…

  4. Groundwater Monitoring Report Project Shoal Area, Corrective Action Unit 447

    SciTech Connect

    2008-01-01

    This report presents the 2007 groundwater monitoring results collected by the U.S. Department of Energy (DOE) Office of Legacy Management (LM) at the Project Shoal Area (PSA) Corrective Action Unit (CAU) 447 located in Churchill County, Nevada. Responsibility for the environmental site restoration of the PSA was transferred from the DOE Office of Environmental Management (DOE-EM) to DOE-LM on October 1, 2006. Requirements for CAU 447, as specified in the Federal Facility Agreement and Consent Order (FFACO 2005) entered into by DOE, the U.S. Department of Defense (DOD), and the State of Nevada, includes groundwater monitoring in support of site closure. This is the first groundwater monitoring report prepared by DOE-LM for the PSA.

  5. Getting Ready for the Human Phenome Project: The 2012 Forum of the Human Variome Project

    PubMed Central

    Oetting, William S.; Robinson, Peter N.; Greenblatt, Marc S.; Cotton, Richard G.; Beck, Tim; Carey, John C.; Doelken, Sandra C.; Girdea, Marta; Groza, Tudor; Hamilton, Carol M.; Hamosh, Ada; Kerner, Berit; MacArthur, Jacqueline A. L.; Maglott, Donna R.; Mons, Barend; Rehm, Heidi L.; Schofield, Paul N.; Searle, Beverly A.; Smedley, Damian; Smith, Cynthia L.; Bernstein, Inge Thomsen; Zankl, Andreas; Zhao, Eric Y.

    2014-01-01

    A forum of the Human Variome Project (HVP) was held as a satellite to the 2012 Annual Meeting of the American Society of Human Genetics in San Francisco, California. The theme of this meeting was “Getting Ready for the Human Phenome Project.” Understanding the genetic contribution to both rare single-gene “Mendelian” disorders and more complex common diseases will require integration of research efforts among many fields and better defined phenotypes. The HVP is dedicated to bringing together researchers and research populations throughout the world to provide the resources to investigate the impact of genetic variation on disease. To this end, there needs to be a greater sharing of phenotype and genotype data. For this to occur, many databases that currently exist will need to become interoperable to allow for the combining of cohorts with similar phenotypes to increase statistical power for studies attempting to identify novel disease genes or causative genetic variants. Improved systems and tools that enhance the collection of phenotype data from clinicians are urgently needed. This meeting begins the HVP’s effort toward this important goal. PMID:23401191

  6. 7 CFR 275.18 - Project area/management unit corrective action plan.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Project area/management unit corrective action plan... SYSTEM Corrective Action § 275.18 Project area/management unit corrective action plan. (a) The State agency shall ensure that corrective action plans are prepared at the project area/management unit...

  7. 7 CFR 275.18 - Project area/management unit corrective action plan.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Project area/management unit corrective action plan... SYSTEM Corrective Action § 275.18 Project area/management unit corrective action plan. (a) The State agency shall ensure that corrective action plans are prepared at the project area/management unit...

  8. 7 CFR 275.18 - Project area/management unit corrective action plan.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Project area/management unit corrective action plan... SYSTEM Corrective Action § 275.18 Project area/management unit corrective action plan. (a) The State agency shall ensure that corrective action plans are prepared at the project area/management unit...

  9. 7 CFR 275.18 - Project area/management unit corrective action plan.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Project area/management unit corrective action plan... SYSTEM Corrective Action § 275.18 Project area/management unit corrective action plan. (a) The State agency shall ensure that corrective action plans are prepared at the project area/management unit...

  10. 7 CFR 275.18 - Project area/management unit corrective action plan.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Project area/management unit corrective action plan... SYSTEM Corrective Action § 275.18 Project area/management unit corrective action plan. (a) The State agency shall ensure that corrective action plans are prepared at the project area/management unit...

  11. 7 CFR 1468.4 - Establishing Conservation Farm Option (CFO) pilot project areas.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... project areas. 1468.4 Section 1468.4 Agriculture Regulations of the Department of Agriculture (Continued... FARM OPTION General Provisions § 1468.4 Establishing Conservation Farm Option (CFO) pilot project areas. (a) CCC may periodically solicit proposals from the public to establish pilot project areas in...

  12. 7 CFR 1468.4 - Establishing Conservation Farm Option (CFO) pilot project areas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... project areas. 1468.4 Section 1468.4 Agriculture Regulations of the Department of Agriculture (Continued... FARM OPTION General Provisions § 1468.4 Establishing Conservation Farm Option (CFO) pilot project areas. (a) CCC may periodically solicit proposals from the public to establish pilot project areas in...

  13. Large-scale data mining pilot project in human genome

    SciTech Connect

    Musick, R.; Fidelis, R.; Slezak, T.

    1997-05-01

    This whitepaper briefly describes a new, aggressive effort in large- scale data Livermore National Labs. The implications of `large- scale` will be clarified Section. In the short term, this effort will focus on several @ssion-critical questions of Genome project. We will adapt current data mining techniques to the Genome domain, to quantify the accuracy of inference results, and lay the groundwork for a more extensive effort in large-scale data mining. A major aspect of the approach is that we will be fully-staffed data warehousing effort in the human Genome area. The long term goal is strong applications- oriented research program in large-@e data mining. The tools, skill set gained will be directly applicable to a wide spectrum of tasks involving a for large spatial and multidimensional data. This includes applications in ensuring non-proliferation, stockpile stewardship, enabling Global Ecology (Materials Database Industrial Ecology), advancing the Biosciences (Human Genome Project), and supporting data for others (Battlefield Management, Health Care).

  14. Draft environmental assessment -- Test Area North pool stabilization project update

    SciTech Connect

    1997-06-01

    The purpose of this Environmental Assessment (EA) is to update the ``Test Area North Pool Stabilization Project`` EA (DOE/EA-1050) and finding of no significant impact (FONSI) issued May 6, 1996. This update analyzes the environmental and health impacts of a drying process for the Three Mile Island (TMI) nuclear reactor core debris canisters now stored underwater in a facility on the Idaho National Engineering and Environmental Laboratory (INEEL). A drying process was analyzed in the predecision versions of the EA released in 1995 but that particular process was determined to be ineffective and dropped form the Ea/FONSI issued May 6, 1996. The origin and nature of the TMI core debris and the proposed drying process are described and analyzed in detail in this EA. As did the 1996 EA, this update analyzes the environmental and health impacts of removing various radioactive materials from underwater storage, dewatering these materials, constructing a new interim dry storage facility, and transporting and placing the materials into the new facility. Also, as did the 1996 EA, this EA analyzes the removal, treatment and disposal of water from the pool, and placement of the facility into a safe, standby condition. The entire action would take place within the boundaries of the INEEL. The materials are currently stored underwater in the Test Area North (TAN) building 607 pool, the new interim dry storage facility would be constructed at the Idaho Chemical Processing Plant (ICPP) which is about 25 miles south of TAN.

  15. Environmental Assessment -- Test Area North pool stabilization project update

    SciTech Connect

    1997-08-01

    The purpose of this Environmental Assessment (EA) is to update the ``Test Area North Pool Stabilization Project`` EA (DOE/EA-1050) and finding of no significant impact (FONSI) issued May 6, 1996. This update analyzes the environmental and health impacts of a drying process for the Three Mile Island (TMI) nuclear reactor core debris canisters now stored underwater in a facility on the Idaho National Engineering and Environmental Laboratory (INEEL). A drying process was analyzed in the predecision versions of the EA released in 1995 but that particular process was determined to be ineffective and dropped from the EA/FONSI issued May 6, 1996. A new drying process was subsequently developed and is analyzed in Section 2.1.2 of this document. As did the 1996 EA, this update analyzes the environmental and health impacts of removing various radioactive materials from underwater storage, dewatering these materials, constructing a new interim dry storage facility, and transporting and placing the materials into the new facility. Also, as did the 1996 EA, this EA analyzes the removal, treatment and disposal of water from the pool, and placement of the facility into a safe, standby condition. The entire action would take place within the boundaries of the INEEL. The materials are currently stored underwater in the Test Area North (TAN) building 607 pool, the new interim dry storage facility would be constructed at the Idaho Chemical Processing Plant (ICPP) which is about 25 miles south of TAN.

  16. The Human Genome Project: how do we protect Australians?

    PubMed

    Stott Despoja, N

    It is the moon landing of the nineties: the ambitious Human Genome Project--identifying the up to 100,000 genes that make up human DNA and the sequences of the three billion base-pairs that comprise the human genome. However, unlike the moon landing, the effects of the genome project will have a fundamental impact on the way we see ourselves and each other.

  17. Non-Human Loss in Rural Areas.

    ERIC Educational Resources Information Center

    Holcomb, Ralph

    This paper examines non-human loss and its psychological effect upon rural people. It discusses the absence of any ritual response to loss, including farm loss, that would otherwise benefit the loss victims or the surrounding society. The dilemma is comparable to that of the "transitional person," the immigrant experience following World…

  18. Evansville Area Earthquake Hazards Mapping Project (EAEHMP) - Progress Report, 2008

    USGS Publications Warehouse

    Boyd, Oliver S.; Haase, Jennifer L.; Moore, David W.

    2009-01-01

    Maps of surficial geology, deterministic and probabilistic seismic hazard, and liquefaction potential index have been prepared by various members of the Evansville Area Earthquake Hazard Mapping Project for seven quadrangles in the Evansville, Indiana, and Henderson, Kentucky, metropolitan areas. The surficial geologic maps feature 23 types of surficial geologic deposits, artificial fill, and undifferentiated bedrock outcrop and include alluvial and lake deposits of the Ohio River valley. Probabilistic and deterministic seismic hazard and liquefaction hazard mapping is made possible by drawing on a wealth of information including surficial geologic maps, water well logs, and in-situ testing profiles using the cone penetration test, standard penetration test, down-hole shear wave velocity tests, and seismic refraction tests. These data were compiled and collected with contributions from the Indiana Geological Survey, Kentucky Geological Survey, Illinois State Geological Survey, United States Geological Survey, and Purdue University. Hazard map products are in progress and are expected to be completed by the end of 2009, with a public roll out in early 2010. Preliminary results suggest that there is a 2 percent probability that peak ground accelerations of about 0.3 g will be exceeded in much of the study area within 50 years, which is similar to the 2002 USGS National Seismic Hazard Maps for a firm rock site value. Accelerations as high as 0.4-0.5 g may be exceeded along the edge of the Ohio River basin. Most of the region outside of the river basin has a low liquefaction potential index (LPI), where the probability that LPI is greater than 5 (that is, there is a high potential for liquefaction) for a M7.7 New Madrid type event is only 20-30 percent. Within the river basin, most of the region has high LPI, where the probability that LPI is greater than 5 for a New Madrid type event is 80-100 percent.

  19. 76 FR 64083 - Loveland Area Projects-2025 Power Marketing Initiative Proposal

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-17

    ... Area Power Administration Loveland Area Projects--2025 Power Marketing Initiative Proposal AGENCY: Western Area Power Administration, DOE. ACTION: Notice of Proposed 2025 Power Marketing Initiative... marketing agency of the Department of Energy (DOE), is seeking comments on this proposed 2025...

  20. The Human Genome Project: big science transforms biology and medicine.

    PubMed

    Hood, Leroy; Rowen, Lee

    2013-01-01

    The Human Genome Project has transformed biology through its integrated big science approach to deciphering a reference human genome sequence along with the complete sequences of key model organisms. The project exemplifies the power, necessity and success of large, integrated, cross-disciplinary efforts - so-called 'big science' - directed towards complex major objectives. In this article, we discuss the ways in which this ambitious endeavor led to the development of novel technologies and analytical tools, and how it brought the expertise of engineers, computer scientists and mathematicians together with biologists. It established an open approach to data sharing and open-source software, thereby making the data resulting from the project accessible to all. The genome sequences of microbes, plants and animals have revolutionized many fields of science, including microbiology, virology, infectious disease and plant biology. Moreover, deeper knowledge of human sequence variation has begun to alter the practice of medicine. The Human Genome Project has inspired subsequent large-scale data acquisition initiatives such as the International HapMap Project, 1000 Genomes, and The Cancer Genome Atlas, as well as the recently announced Human Brain Project and the emerging Human Proteome Project.

  1. Growth of ice particle mass and projected area during riming

    NASA Astrophysics Data System (ADS)

    Erfani, Ehsan; Mitchell, David L.

    2017-01-01

    There is a long-standing challenge in cloud and climate models to simulate the process of ice particle riming realistically, partly due to the unrealistic parameterization of the growth of ice particle mass (m) and projected area (A) during riming. This study addresses this problem, utilizing ground-based measurements of m and ice particle maximum dimension (D) as well as theory to formulate simple expressions describing the dependence of m and A on riming. It was observed that β in the m - D power law m = α Dβ appears independent of riming during the phase 1 (before the formation of graupel), with α accounting for the ice particle mass increase due to riming. This semi-empirical approach accounts for the degree of riming and renders a gradual and smooth ice particle growth process from unrimed ice particles to graupel, and thus avoids discontinuities in m and A during accretional growth. Once the graupel with quasi-spherical shape forms, D increases with an increase in m and A (phase 2 of riming). The treatment for riming is explicit, and includes the parameterization of the ice crystal-cloud droplet collision efficiency (Ec) for hexagonal columns and plates using hydrodynamic theory. In particular, Ec for cloud droplet diameters less than 10 µm are estimated, and under some conditions observed in mixed-phase clouds, these droplets can account for roughly half of the mass growth rate from riming. These physically meaningful yet simple methods can be used in models to improve the riming process.

  2. The human genome project: an historical perspective for social workers.

    PubMed

    Saunders, Marlene

    2011-01-01

    Having mapped the human genome, the Human Genome Project maintains that certain genes can be linked to specific diseases and certain forms of human behavior. This breakthrough, it is hoped, will lead to the effective treatment, even the elimination of serious, debilitating illnesses for all groups of people. However, because the project conjures up memories of eugenics, the project raises concerns about its potential for identifying and linking diseases and social conditions (e.g., criminal behavior) to certain groups. This article places the Human Genome Project in historical context in terms of its resemblance to the eugenics movement in America and a period in social work history when the profession embraced eugenics and was guided by the movement's premises in its response to poor people.

  3. Project Heroes: A Humanities Curriculum for the Learning Disabled.

    ERIC Educational Resources Information Center

    Sharp, Linda Schaffner

    1981-01-01

    Project Heroes is a humanities program for learning disabled children which is designed to maximize four principles--appreciation of process, acknowledgement of independence, development of a sense of worth, and skill acquisition. (SB)

  4. [Discussion on water conservancy projects and schistosomiasis control in Poyang Lake area].

    PubMed

    Liu, Dao-Nan

    2013-02-01

    According to the schistosomiasis endemic situation in the Poyang Lake area, this paper analyzes the relationship between the water conservancy projects and schistosomiasis control, and reviews and discusses the effects of the Water Level Control Project of Poyang Lake, the Lake Dike Slope Hardening Project, and the Lifting Delta and Descending Beach Project on Oncomelania snail control.

  5. The Hammond Humane Education Project (Final Report).

    ERIC Educational Resources Information Center

    Vockell, Edward L.; Hodal, E. Frank

    The paper assesses an effort by the elementary school system of Hammond, Indiana, to develop and implement an educational program to improve children's attitudes toward animal life. Three levels of humane education treatment were introduced. The first level, introduced in seven schools, consisted of an intensive program involving humane education…

  6. Design Projects in Human Anatomy & Physiology

    ERIC Educational Resources Information Center

    Polizzotto, Kristin; Ortiz, Mary T.

    2008-01-01

    Very often, some type of writing assignment is required in college entry-level Human Anatomy and Physiology courses. This assignment can be anything from an essay to a research paper on the literature, focusing on a faculty-approved topic of interest to the student. As educators who teach Human Anatomy and Physiology at an urban community college,…

  7. The lawful uses of knowledge from the Human Genome Project

    SciTech Connect

    Grad, F.P.

    1994-04-15

    Part I of this study deals with the right to know or not to know personal genetic information, and examines available legal protections of the right of privacy and the adverse effect of the disclosure of genetic information both on employment and insurance interests and on self esteem and protection of personal integrity. The study examines the rationale for the legal protection of privacy as the protection of a public interest. It examines the very limited protections currently available for privacy interests, including genetic privacy interests, and concludes that there is a need for broader, more far-reaching legal protections. The second part of the study is based on the assumption that as major a project as the Human Genome Project, spending billions of dollars on science which is health related, will indeed be applied for preventive and therapeutic public health purposes, as it has been in the past. It also addresses the recurring fear that public health initiatives in the genetic area must evolve a new eugenic agenda, that we must not repeat the miserable discriminatory experiences of the past.

  8. Body mass scaling of projected frontal area in competitive cyclists.

    PubMed

    Heil, D P

    2001-08-01

    The primary purpose of this study was to evaluate the scaling relationship between body mass (mb) and projected frontal area (AP) of competitive male cyclists whilst allowing statistically for the influence of bicycle geometry. A group of 21 cyclists [mean mb 74.4 (SD 7.2) kg, mean height 1.82 (SD 0.06) m, mean age 23.6 (SD 5.1) years] volunteered to have AP determined from photographs at three trunk angles (TA: 5 degrees, 15 degrees, 25 degrees) for each of three seat-tube angles (STA: 70 degrees, 75 degrees, 80 degrees) using a modified cycle ergometer. Using multiple log-linear regression analysis procedures, the following equation was developed: Body AP (meters squared) = 0.00433 x (STA0.172) x (TA0.0965) x (mb0.762) (r2 = 0.73, SEE = 0.017 m2) (n = 183 images total). This equation indicates that after allowing for the independent influence of STA and TA on AP, AP was proportional to mb raised to the +0.762 power (i.e. Ap is directly proportional to 0.762). The 95% confidence interval for this exponent (0.670-0.854) barely included the theoretical two-thirds value but not the +0.55 value for AP or the +0.32 value for submaximal metabolic power (Ws) of outdoor cycling reported in the literature. Further analysis of wind tunnel data reported in the literature suggests that the coefficient of drag (CD) is proportional to mb raised to the -0.45 power. When combined with the present study findings, it is suggested that the drag area (CD x AP), which should be proportional to Ws at submaximal cycling velocities, is proportional to mb to the +0.312 power (i.e. CD x AP is directly proportional to mb-0.45) x (mb+0.762) = mb+0.312), which is consistent with the +0.32 exponent for Ws in the literature.

  9. Human liver proteome project: plan, progress, and perspectives.

    PubMed

    He, Fuchu

    2005-12-01

    The Human Liver Proteome Project is the first initiative of the human proteome project for human organs/tissues and aims at writing a modern Prometheus myth. Its global scientific objectives are to reveal the "solar system" of the human liver proteome, expression profiles, modification profiles, a protein linkage (protein-protein interaction) map, and a proteome localization map, and to define an ORFeome, physiome, and pathome. Since it was first proposed in April 2002, the Human Liver Proteome Project has attracted more than 100 laboratories from all over the world. In the ensuing 3 years, we set up a management infrastructure, identified reference laboratories, confirmed standard operating procedures, initiated international research collaborations, and finally achieved the first set of expression profile data.

  10. Genomics and the Human Genome Project: implications for psychiatry.

    PubMed

    Kelsoe, John R

    2004-11-01

    In the past decade the Human Genome Project has made extraordinary strides in understanding of fundamental human genetics. The complete human genetic sequence has been determined, and the chromosomal location of almost all human genes identified. Presently, a large international consortium, the HapMap Project, is working to identify a large portion of genetic variation in different human populations and the structure and relationship of these variants to each other. The Human Genome Project has approached human genetics on a scale not previously seen in biology. This has been made possible by dramatic advances in high throughput technology and bio-informatics. Tools such as gene chips and micro-arrays have spawned an entirely new strategy to examine the function and expression of genes in a massively parallel fashion. Together these tools have dramatically advanced our knowledge about the human genome. They promise powerful new approaches to complex genetic traits such as psychiatric illness. The goals and progress of the Human Genome Project and the technology involved are reviewed. The implications of this science for psychiatric genetics are discussed.

  11. Local Area Networks--The ENFI Project (Writing on the College Campus).

    ERIC Educational Resources Information Center

    Stine, Linda

    1989-01-01

    Describes Electronic Networks for Interaction (ENFI), a local area network project developed at Gallaudet University to empower students with hearing impairments. Notes that this project can be adapted easily for use with traditional students. (MM)

  12. 76 FR 64085 - Post-2014 Resource Pool-Loveland Area Projects, Final Power Allocation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-17

    ... Area Power Administration Post-2014 Resource Pool-Loveland Area Projects, Final Power Allocation AGENCY...), announces its Post-2014 Resource Pool-Loveland Area Projects, Final Power Allocation developed under the requirements of subpart C-Power Marketing Initiative of the Energy Planning and Management Program...

  13. Understanding earthquake hazards in urban areas - Evansville Area Earthquake Hazards Mapping Project

    USGS Publications Warehouse

    Boyd, Oliver S.

    2012-01-01

    The region surrounding Evansville, Indiana, has experienced minor damage from earthquakes several times in the past 200 years. Because of this history and the proximity of Evansville to the Wabash Valley and New Madrid seismic zones, there is concern among nearby communities about hazards from earthquakes. Earthquakes currently cannot be predicted, but scientists can estimate how strongly the ground is likely to shake as a result of an earthquake and are able to design structures to withstand this estimated ground shaking. Earthquake-hazard maps provide one way of conveying such information and can help the region of Evansville prepare for future earthquakes and reduce earthquake-caused loss of life and financial and structural loss. The Evansville Area Earthquake Hazards Mapping Project (EAEHMP) has produced three types of hazard maps for the Evansville area: (1) probabilistic seismic-hazard maps show the ground motion that is expected to be exceeded with a given probability within a given period of time; (2) scenario ground-shaking maps show the expected shaking from two specific scenario earthquakes; (3) liquefaction-potential maps show how likely the strong ground shaking from the scenario earthquakes is to produce liquefaction. These maps complement the U.S. Geological Survey's National Seismic Hazard Maps but are more detailed regionally and take into account surficial geology, soil thickness, and soil stiffness; these elements greatly affect ground shaking.

  14. Human Life and American Values Projection

    DTIC Science & Technology

    2013-03-01

    compelling evidence exists within multiple disciplines— science and biology, philosophy, religion, and law—that human life begins at conception...beyond national boundaries, and contributes to a global and universal understanding of values. Science and Biology Many within the scientific and...posture themselves above scientific findings.26 Science and biology emphasize that conception is the moment when the human DNA is established. At the

  15. Some Equal-area, Conformal and Conventional Map Projections: A Tutorial Review

    NASA Astrophysics Data System (ADS)

    Ghaderpour, Ebrahim

    2016-09-01

    Map projections have been widely used in many areas such as geography, oceanography, meteorology, geology, geodesy, photogrammetry and global positioning systems. Understanding different types of map projections is very crucial in these areas. This paper presents a tutorial review of various types of current map projections such as equal-area, conformal and conventional. We present these map projections from a model of the Earth to a flat sheet of paper or map and derive the plotting equations for them in detail. The first fundamental form and the Gaussian fundamental quantities are defined and applied to obtain the plotting equations and distortions in length, shape and size for some of these map projections.

  16. Large rainfall changes consistently projected over substantial areas of tropical land

    NASA Astrophysics Data System (ADS)

    Chadwick, Robin; Good, Peter; Martin, Gill; Rowell, David P.

    2016-02-01

    Many tropical countries are exceptionally vulnerable to changes in rainfall patterns, with floods or droughts often severely affecting human life and health, food and water supplies, ecosystems and infrastructure. There is widespread disagreement among climate model projections of how and where rainfall will change over tropical land at the regional scales relevant to impacts, with different models predicting the position of current tropical wet and dry regions to shift in different ways. Here we show that despite uncertainty in the location of future rainfall shifts, climate models consistently project that large rainfall changes will occur for a considerable proportion of tropical land over the twenty-first century. The area of semi-arid land affected by large changes under a higher emissions scenario is likely to be greater than during even the most extreme regional wet or dry periods of the twentieth century, such as the Sahel drought of the late 1960s to 1990s. Substantial changes are projected to occur by mid-century--earlier than previously expected--and to intensify in line with global temperature rise. Therefore, current climate projections contain quantitative, decision-relevant information on future regional rainfall changes, particularly with regard to climate change mitigation policy.

  17. Underground Test Area Project Waste Management Plan (Rev. No. 2, April 2002)

    SciTech Connect

    IT Corporation, Las Vegas

    2002-04-24

    The U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Operations Office (NNSA/NV) initiated the UGTA Project to characterize the risk posed to human health and the environment as a result of underground nuclear testing activities at the Nevada Test Site (NTS). The UGTA Project investigation sites have been grouped into Corrective Action Units (CAUs) in accordance with the most recent version of the Federal Facility Agreement and Consent Order. The primary UGTA objective is to gather data to characterize the groundwater aquifers beneath the NTS and adjacent lands. The investigations proposed under the UGTA program may involve the drilling and sampling of new wells; recompletion, monitoring, and sampling of existing wells; well development and hydrologic/ aquifer testing; geophysical surveys; and subsidence crater recharge evaluation. Those wastes generated as a result of these activities will be managed in accordance with existing federal and state regulations, DOE Orders, and NNSA/NV waste minimization and pollution prevention objectives. This Waste Management Plan provides a general framework for all Underground Test Area (UGTA) Project participants to follow for the characterization, storage/accumulation, treatment, and disposal of wastes generated by UGTA Project activities. The objective of this waste management plan is to provide guidelines to minimize waste generation and to properly manage wastes that are produced. Attachment 1 to this plan is the Fluid Management Plan and details specific strategies for management of fluids produced under UGTA operations.

  18. Terminal Area Productivity Program: Dynamic Spacing Human Factors

    NASA Technical Reports Server (NTRS)

    Kanki, Barbara G.

    1997-01-01

    Dynamic spacing human factors deals with the following human factors issues: define controller limits to incorporating dynamic changes in separation standards; identify timing, planning, and coordination strategies; and consider consistency with current practices, policies, and regulations. The AVOSS technologies will make it possible to reduce separation standards in the terminal area under certain meteorological conditions. This paper contains the following sections: Dynamic space human factors overview, Preliminary tests, and current research status & plans.

  19. Democratizing Human Genome Project Information: A Model Program for Education, Information and Debate in Public Libraries.

    ERIC Educational Resources Information Center

    Pollack, Miriam

    The "Mapping the Human Genome" project demonstrated that librarians can help whomever they serve in accessing information resources in the areas of biological and health information, whether it is the scientists who are developing the information or a member of the public who is using the information. Public libraries can guide library…

  20. A cell-based approach to the human proteome project.

    PubMed

    Kelleher, Neil L

    2012-10-01

    The general scope of a project to determine the protein molecules that comprise the cells within the human body is framed. By focusing on protein primary structure as expressed in specific cell types, this concept for a cell-based version of the Human Proteome Project (CB-HPP) is crafted in a manner analogous to the Human Genome Project while recognizing that cells provide a primary context in which to define a proteome. Several activities flow from this articulation of the HPP, which enables the definition of clear milestones and deliverables. The CB-HPP highlights major gaps in our knowledge regarding cell heterogeneity and protein isoforms, and calls for development of technology that is capable of defining all human cell types and their proteomes. The main activities will involve mapping and sorting cell types combined with the application of beyond the state-of-the art in protein mass spectrometry.

  1. Human Activity Recognition in AAL Environments Using Random Projections

    PubMed Central

    Damaševičius, Robertas; Vasiljevas, Mindaugas; Šalkevičius, Justas; Woźniak, Marcin

    2016-01-01

    Automatic human activity recognition systems aim to capture the state of the user and its environment by exploiting heterogeneous sensors attached to the subject's body and permit continuous monitoring of numerous physiological signals reflecting the state of human actions. Successful identification of human activities can be immensely useful in healthcare applications for Ambient Assisted Living (AAL), for automatic and intelligent activity monitoring systems developed for elderly and disabled people. In this paper, we propose the method for activity recognition and subject identification based on random projections from high-dimensional feature space to low-dimensional projection space, where the classes are separated using the Jaccard distance between probability density functions of projected data. Two HAR domain tasks are considered: activity identification and subject identification. The experimental results using the proposed method with Human Activity Dataset (HAD) data are presented. PMID:27413392

  2. Human Activity Recognition in AAL Environments Using Random Projections.

    PubMed

    Damaševičius, Robertas; Vasiljevas, Mindaugas; Šalkevičius, Justas; Woźniak, Marcin

    2016-01-01

    Automatic human activity recognition systems aim to capture the state of the user and its environment by exploiting heterogeneous sensors attached to the subject's body and permit continuous monitoring of numerous physiological signals reflecting the state of human actions. Successful identification of human activities can be immensely useful in healthcare applications for Ambient Assisted Living (AAL), for automatic and intelligent activity monitoring systems developed for elderly and disabled people. In this paper, we propose the method for activity recognition and subject identification based on random projections from high-dimensional feature space to low-dimensional projection space, where the classes are separated using the Jaccard distance between probability density functions of projected data. Two HAR domain tasks are considered: activity identification and subject identification. The experimental results using the proposed method with Human Activity Dataset (HAD) data are presented.

  3. A Cell-Based Approach to the Human Proteome Project

    NASA Astrophysics Data System (ADS)

    Kelleher, Neil L.

    2012-10-01

    The general scope of a project to determine the protein molecules that comprise the cells within the human body is framed. By focusing on protein primary structure as expressed in specific cell types, this concept for a cell-based version of the Human Proteome Project (CB-HPP) is crafted in a manner analogous to the Human Genome Project while recognizing that cells provide a primary context in which to define a proteome. Several activities flow from this articulation of the HPP, which enables the definition of clear milestones and deliverables. The CB-HPP highlights major gaps in our knowledge regarding cell heterogeneity and protein isoforms, and calls for development of technology that is capable of defining all human cell types and their proteomes. The main activities will involve mapping and sorting cell types combined with the application of beyond the state-of-the art in protein mass spectrometry.

  4. Human Sensing Fusion Project for Safety and Health Society

    NASA Astrophysics Data System (ADS)

    Maenaka, Kazusuke

    This paper introduces objectives and status of “Human sensing fusion project” in the Exploratory Research for Advanced Technology (ERATO) scheme produced by Japan Science and Technology Agency (JST). This project was started in December 2007 and the laboratory with 11 members opened on April 2008. The aim of this project is to realize a human activity-monitoring device with many kinds of sensors in ultimate small size so that the device can be pasted or patched to the human body, and to establish the algorism for understanding human condition including both physical and mental conditions from obtained data. This system can be used towards the prevention of the danger of accidents and the maintenance of health. The actual research has just begun and preparations for project are well under way.

  5. 76 FR 33333 - Use of Small Area Fair Market Rents for Project Base Vouchers in the Dallas TX Metropolitan Area

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT Use of Small Area Fair Market Rents for Project Base Vouchers in the Dallas TX Metropolitan Area AGENCY: Office of the Assistant Secretary for Public and Indian Housing, HUD. ACTION:...

  6. Tunnelling in Urbanised Areas - Geotechnical Case Studies at Different Project Stages

    NASA Astrophysics Data System (ADS)

    Eder, Stefan; Poscher, Gerhard; Kohl, Bernhard

    Tunnelling in urbanised areas is always a challenge for the client and the contractor as well as for the designers, the engineers, and the geologists. The high demand for space and the disturbance of existing infrastructures by construction measures increasingly forces future infrastructure projects to be carried out underground. At the same time, interferences with human, natural or water resources shall be reduced and noise, dust, as well as site traffic shall be minimised. Quite frequently, politics also come into play. All these factors may lead to pre-determined routes, with ground conditions which may not always be very favourable. This article presents examples of different projects at different stages and emphasizes the importance of engineering geology in the route selection process. The most promising options are routes located in ground, which is not sensitive to settlement and/or water ingress. A longer route in favourable ground conditions is to be given preference over a shorter route in adverse ground conditions. In case of no alternative, the risk of surface settlements and exploding construction costs have to be taken into account. The first project presented is the railway line in the Inn valley / Tyrol, comprising four sections in urbanised areas, which - due to environmental and political reasons - have to cross infrastructure facilities and traffic lines, often in unfavourable ground conditions. There is a variety of construction methods in the tender design to be applied in urbanised tunnelling ranging from NATM tunnels with local groundwater draw-down and jet grouting enclosure against water pressure, to TBM-driven tunnels with hydro-shield. The second project is a planned by-pass for the city of Linz, which is at the environmental impact assessment stage. The alignment is dominated by geological considerations, avoiding unfavourable ground conditions to the greatest possible extent.

  7. ESTCP Pilot Project Wide Area Assessment for Munitions Response

    DTIC Science & Technology

    2008-07-01

    and open , gradual slopes, and valleys between steep hills. Vegetation varies from sparse shrubs and trees to dense, continuous groves. The site...technologies that locate areas intentionally used for military activities such as impact areas, target areas, or other “ concentrations ” such as open ...number cannot be used to define an anomaly density that constitutes ‘ concentrated ,’ as the contrast between the site background anomaly density and the

  8. The human proteome project: current state and future direction.

    PubMed

    Legrain, Pierre; Aebersold, Ruedi; Archakov, Alexander; Bairoch, Amos; Bala, Kumar; Beretta, Laura; Bergeron, John; Borchers, Christoph H; Corthals, Garry L; Costello, Catherine E; Deutsch, Eric W; Domon, Bruno; Hancock, William; He, Fuchu; Hochstrasser, Denis; Marko-Varga, György; Salekdeh, Ghasem Hosseini; Sechi, Salvatore; Snyder, Michael; Srivastava, Sudhir; Uhlén, Mathias; Wu, Cathy H; Yamamoto, Tadashi; Paik, Young-Ki; Omenn, Gilbert S

    2011-07-01

    After the successful completion of the Human Genome Project, the Human Proteome Organization has recently officially launched a global Human Proteome Project (HPP), which is designed to map the entire human protein set. Given the lack of protein-level evidence for about 30% of the estimated 20,300 protein-coding genes, a systematic global effort will be necessary to achieve this goal with respect to protein abundance, distribution, subcellular localization, interaction with other biomolecules, and functions at specific time points. As a general experimental strategy, HPP research groups will use the three working pillars for HPP: mass spectrometry, antibody capture, and bioinformatics tools and knowledge bases. The HPP participants will take advantage of the output and cross-analyses from the ongoing Human Proteome Organization initiatives and a chromosome-centric protein mapping strategy, termed C-HPP, with which many national teams are currently engaged. In addition, numerous biologically driven and disease-oriented projects will be stimulated and facilitated by the HPP. Timely planning with proper governance of HPP will deliver a protein parts list, reagents, and tools for protein studies and analyses, and a stronger basis for personalized medicine. The Human Proteome Organization urges each national research funding agency and the scientific community at large to identify their preferred pathways to participate in aspects of this highly promising project in a HPP consortium of funders and investigators.

  9. Projected Allied Health and Nursing Training Needs for a Seven-County Area in West Virginia.

    ERIC Educational Resources Information Center

    Bertram, Charles L.; And Others

    This report describes a project that developed and field tested a model for projecting state-wide manpower needs in the allied health and nursing occupations in West Virginia and presents projections made for sixteen allied health and nursing occupations in the Charleston area. The content of the report is presented in three sections. The first…

  10. Aberdeen Area Final Evaluation Report, ESEA Title I Project, Fiscal Year 1974.

    ERIC Educational Resources Information Center

    Bureau of Indian Affairs (Dept. of Interior), Aberdeen, SD. Aberdeen Area Office.

    Compiled from the final evaluation reports of 36 direct instruction projects and 1 Area Technical Assistance project (94 percent of which were contracted and administered by American Indian tribes or Indian school boards), this report is a summative evaluation of 1974 Title I projects in North and South Dakota. A brief introduction describes the…

  11. NASA UAS Integration into the NAS Project: Human Systems Integration

    NASA Technical Reports Server (NTRS)

    Shively, Jay

    2016-01-01

    This presentation provides an overview of the work the Human Systems Integration (HSI) sub-project has done on detect and avoid (DAA) displays while working on the UAS (Unmanned Aircraft System) Integration into the NAS project. The most recent simulation on DAA interoperability with Traffic Collision Avoidance System (TCAS) is discussed in the most detail. The relationship of the work to the larger UAS community and next steps are also detailed.

  12. Lowell Area Council on Interlibrary Network Radio Project.

    ERIC Educational Resources Information Center

    Panciers, David J.

    In the fall of 1973, public, school, and college librarians in the Lowell, Massachusetts, area formed the Lowell Area Council on Interlibrary Networks (LACOIN). With a grant from the Library Services and Construction Act, Title III, LACOIN initiated library-sponsored public affairs radio broadcasting for its community. Utilizing the Lowell…

  13. 7 CFR 1450.202 - Project area selection criteria.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS BIOMASS CROP ASSISTANCE PROGRAM...) The dry tons of renewable biomass projected to be available from sources other than the eligible crops... opportunity for producers and local investors to participate in the ownership of the biomass...

  14. 7 CFR 1450.202 - Project area selection criteria.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS BIOMASS CROP ASSISTANCE PROGRAM...) The dry tons of renewable biomass projected to be available from sources other than the eligible crops... opportunity for producers and local investors to participate in the ownership of the biomass...

  15. 7 CFR 1450.202 - Project area selection criteria.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS BIOMASS CROP ASSISTANCE PROGRAM...) The dry tons of renewable biomass projected to be available from sources other than the eligible crops... opportunity for producers and local investors to participate in the ownership of the biomass...

  16. 7 CFR 1450.202 - Project area selection criteria.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS BIOMASS CROP ASSISTANCE PROGRAM...) The dry tons of renewable biomass projected to be available from sources other than the eligible crops... opportunity for producers and local investors to participate in the ownership of the biomass...

  17. The Human Genome Diversity (HGD) Project. Summary document

    SciTech Connect

    1993-12-31

    In 1991 a group of human geneticists and molecular biologists proposed to the scientific community that a world wide survey be undertaken of variation in the human genome. To aid their considerations, the committee therefore decided to hold a small series of international workshops to explore the major scientific issues involved. The intention was to define a framework for the project which could provide a basis for much wider and more detailed discussion and planning--it was recognized that the successful implementation of the proposed project, which has come to be known as the Human Genome Diversity (HGD) Project, would not only involve scientists but also various national and international non-scientific groups all of which should contribute to the project`s development. The international HGD workshop held in Sardinia in September 1993 was the last in the initial series of planning workshops. As such it not only explored new ground but also pulled together into a more coherent form much of the formal and informal discussion that had taken place in the preceding two years. This report presents the deliberations of the Sardinia workshop within a consideration of the overall development of the HGD Project to date.

  18. Los Alamos Science: The Human Genome Project. Number 20, 1992

    DOE R&D Accomplishments Database

    Cooper, N. G.; Shea, N. eds.

    1992-01-01

    This document provides a broad overview of the Human Genome Project, with particular emphasis on work being done at Los Alamos. It tries to emphasize the scientific aspects of the project, compared to the more speculative information presented in the popular press. There is a brief introduction to modern genetics, including a review of classic work. There is a broad overview of the Genome Project, describing what the project is, what are some of its major five-year goals, what are major technological challenges ahead of the project, and what can the field of biology, as well as society expect to see as benefits from this project. Specific results on the efforts directed at mapping chromosomes 16 and 5 are discussed. A brief introduction to DNA libraries is presented, bearing in mind that Los Alamos has housed such libraries for many years prior to the Genome Project. Information on efforts to do applied computational work related to the project are discussed, as well as experimental efforts to do rapid DNA sequencing by means of single-molecule detection using applied spectroscopic methods. The article introduces the Los Alamos staff which are working on the Genome Project, and concludes with brief discussions on ethical, legal, and social implications of this work; a brief glimpse of genetics as it may be practiced in the next century; and a glossary of relevant terms.

  19. Los Alamos Science: The Human Genome Project. Number 20, 1992

    SciTech Connect

    Cooper, N G; Shea, N

    1992-01-01

    This article provides a broad overview of the Human Genome Project, with particular emphasis on work being done at Los Alamos. It tries to emphasize the scientific aspects of the project, compared to the more speculative information presented in the popular press. There is a brief introduction to modern genetics, including a review of classic work. There is a broad overview of the Genome Project, describing what the project is, what are some of its major five-year goals, what are major technological challenges ahead of the project, and what can the field of biology, as well as society expect to see as benefits from this project. Specific results on the efforts directed at mapping chromosomes 16 and 5 are discussed. A brief introduction to DNA libraries is presented, bearing in mind that Los Alamos has housed such libraries for many years prior to the Genome Project. Information on efforts to do applied computational work related to the project are discussed, as well as experimental efforts to do rapid DNA sequencing by means of single-molecule detection using applied spectroscopic methods. The article introduces the Los Alamos staff which are working on the Genome Project, and concludes with brief discussions on ethical, legal, and social implications of this work; a brief glimpse of genetics as it may be practiced in the next century; and a glossary of relevant terms.

  20. Genes after the human genome project.

    PubMed

    Baetu, Tudor M

    2012-03-01

    While the Human Genome Nomenclature Committee (HGNC) concept of the gene can accommodate a wide variety of genomic sequences contributing to phenotypic outcomes, it fails to specify how sequences should be grouped when dealing with complex loci consisting of adjacent/overlapping sequences contributing to the same phenotype, distant sequences shown to contribute to the same gene product, and partially overlapping sequences identified by different techniques. The purpose of this paper is to review recently proposed concepts of the gene and critically assess how well they succeed in addressing the above problems while preserving the degree of generality achieved by the HGNC concept. I conclude that a dynamic interplay between mapping and syntax-based concepts is required in order to satisfy these desiderata.

  1. Estimation of projection errors in human ocular fundus imaging.

    PubMed

    Doelemeyer, A; Petrig, B L

    2000-03-01

    Photogrammetric analysis of features in human ocular fundus images is affected by various sources of errors, for example aberrations of the camera and eye optics. Another--usually disregarded--type of distortion arises from projecting the near spherical shape of the fundus onto a planar imaging device. In this paper we quantify such projection errors based on geometrical analysis of the reduced model eye imaged by a pinhole camera. The projection error found near the edge of a 50 degrees fundus image is 24%. In addition, the influence of axial ametropia is investigated for both myopia and hyperopia. The projection errors found in hyperopia are similar to those in emmetropia, but decrease in myopia. Spherical as well as ellipsoidal eye shapes were used in the above calculation and their effect was compared. Our results suggest that the simple spherical eye shape is sufficient for correcting projection distortions within a range of ametropia from -5 to +5 diopters.

  2. Libyan Military Power Projection in Sub-Saharan Area.

    DTIC Science & Technology

    1981-06-12

    credible. One pays attention to his great design to unify all the Arabic world. Can such a thing happen? And how could a military power in this area be...6th century. The Berber cultural substratem was totally submerged in Libya in the ninth and tenth centuries by large-scale immigration of Arabic ...speaking, nomadic tribes from central Arabia. That explains the heavy Arabic feeling of the modern inhabitants. It may be said of numerous areas that

  3. [The Human Genome Project, genetic viability and genetic epidemiology].

    PubMed

    Hagymási, Krisztina; Tulassay, Zsolt

    2005-12-18

    The goal of the Human Genome Project to elucidate the complete sequence of the human genome has been achieved. The aims of the "post-genome" era are explaining the genetic information, characterisation of functional elements encoded in the human genome and mapping the human genetic variability as well. Two unrelated human beings also share 99.9% of their genomic sequence. The difference of 0.1% is the result of genetic polymorphisms: single nucleotide polymorphisms, repetitive sequences and insertion/deletion. The genetic differences, coupled with environmental exposures will determine the phenotypic variation we observe in health or disease. The disease-causing genetic variants can be identified by linkage analysis or association studies. The knowledge of human genome and application of multiple biomarkers will improve our ability to identify individuals at risk, so that preventive interventions can be applied, earlier diagnosis can be made and treatment can be optimized.

  4. City of Huntsville Public Housing Areas STEM Initiative Project

    NASA Astrophysics Data System (ADS)

    Colon, Tomeka; Smith, Cydale; Pugh, Marcus; Budak, Satilmis; Muntele, Claudiu

    2012-02-01

    Students in high-poverty and high-minority schools are entering the classroom without the knowledge and skills they need to succeed. In order to bridge the gaps in opportunity and achievement that separate low-income students and students of color from other young Americans, we have introduced elementary and middle school students to the basic concepts of biology, chemistry, physics, and engineering. Within the project, we have provided students with excellent learning opportunities, engaging hands-on experiences, and outstanding advising and mentoring. We have assessed student development and impact before, during, and after the program.

  5. Discontinued drug projects in the respiratory therapeutic area during 2012.

    PubMed

    Snell, Noel J C

    2014-03-01

    During 2012, a number of respiratory drug projects and individual agents were discontinued, for a variety of reasons, including toxicity, lack of efficacy, commercial re-evaluation and change in corporate focus. These included three antagonists of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTh2), which had been evaluated in allergic respiratory disease and (in one case) chronic obstructive pulmonary disease (COPD), and other agents intended for the treatment of asthma, COPD, pulmonary hypertension and lung fibrosis. These have been reviewed against the background of a general reduction in respiratory research by the pharmaceutical industry.

  6. Head of Human Genome Project Retracts 5 Journal Articles.

    ERIC Educational Resources Information Center

    Haworth, Karla

    1996-01-01

    Five published leukemia studies have been retracted by the director of the Human Genome Project because they were based on falsified data from a graduate student, although some of the conclusions are still supported. Inconsistencies were discovered by a peer reviewer and were also found in the student's other work. (MSE)

  7. The Human Genome Project: Biology, Computers, and Privacy.

    ERIC Educational Resources Information Center

    Cutter, Mary Ann G.; Drexler, Edward; Gottesman, Kay S.; Goulding, Philip G.; McCullough, Laurence B.; McInerney, Joseph D.; Micikas, Lynda B.; Mural, Richard J.; Murray, Jeffrey C.; Zola, John

    This module, for high school teachers, is the second of two modules about the Human Genome Project (HGP) produced by the Biological Sciences Curriculum Study (BSCS). The first section of this module provides background information for teachers about the structure and objectives of the HGP, aspects of the science and technology that underlie the…

  8. Enhancing Biology Instruction with the Human Genome Project

    ERIC Educational Resources Information Center

    Buxeda, Rosa J.; Moore-Russo, Deborah A.

    2003-01-01

    The Human Genome Project (HGP) is a recent scientific milestone that has received notable attention. This article shows how a biology course is using the HGP to enhance students' experiences by providing awareness of cutting edge research, with information on new emerging career options, and with opportunities to consider ethical questions raised…

  9. The Human Brain Project: social and ethical challenges.

    PubMed

    Rose, Nikolas

    2014-06-18

    Focusing on the Human Brain Project, I discuss some social and ethical challenges raised by such programs of research: the possibility of a unified knowledge of "the brain," balancing privacy and the public good, dilemmas of "dual use," brain-computer interfaces, and "responsible research and innovation" in governance of emerging technologies.

  10. Landscaping Habitat for Humanity Homes: A Community Outreach Project

    ERIC Educational Resources Information Center

    Ramsay, Jodie L.

    2008-01-01

    The purpose of this project is to incorporate a community service component into a Biology course at Northern State University (NSU) in Aberdeen, SD. Students in an upper-level botany course (Plant Structure and Function) provide landscaping services to homeowners who have purchased homes through Habitat for Humanity. Homeowner satisfaction with…

  11. The Human Functional Genomics Project: Understanding Generation of Diversity.

    PubMed

    Pappalardo, Jenna L; Hafler, David A

    2016-11-03

    Generation of biologic diversity is a cornerstone of immunity, yet the tools to investigate the causal influence of genetic and environmental factors have been greatly limited. Studies from the Human Functional Genomics Project, presented in Cell and other Cell Press journals, integrate environmental and genetic factors with the direction and magnitude of immune responses to decipher inflammatory disease pathogenesis.

  12. 7 CFR 634.12 - Eligible project areas.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... agricultural portion of a 208 water quality management plan, or revised portions thereof, and have identified agricultural nonpoint source water quality problems are eligible for authorization under RCWP. Those critical areas or sources of pollutants significantly contributing to the water quality problems are eligible...

  13. 7 CFR 634.12 - Eligible project areas.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... agricultural portion of a 208 water quality management plan, or revised portions thereof, and have identified agricultural nonpoint source water quality problems are eligible for authorization under RCWP. Those critical areas or sources of pollutants significantly contributing to the water quality problems are eligible...

  14. 7 CFR 634.12 - Eligible project areas.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... agricultural portion of a 208 water quality management plan, or revised portions thereof, and have identified agricultural nonpoint source water quality problems are eligible for authorization under RCWP. Those critical areas or sources of pollutants significantly contributing to the water quality problems are eligible...

  15. 7 CFR 634.12 - Eligible project areas.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... agricultural portion of a 208 water quality management plan, or revised portions thereof, and have identified agricultural nonpoint source water quality problems are eligible for authorization under RCWP. Those critical areas or sources of pollutants significantly contributing to the water quality problems are eligible...

  16. 7 CFR 634.12 - Eligible project areas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... agricultural portion of a 208 water quality management plan, or revised portions thereof, and have identified agricultural nonpoint source water quality problems are eligible for authorization under RCWP. Those critical areas or sources of pollutants significantly contributing to the water quality problems are eligible...

  17. Projecting crop yield in northern high latitude area.

    PubMed

    Matsumura, Kanichiro

    2014-01-01

    Changing climatic conditions on seasonal and longer time scales influence agricultural production. Improvement of soil and fertilizer is a strong factor in agricultural production, but agricultural production is influenced by climate conditions even in highly developed countries. It is valuable if fewer predictors make it possible to conduct future projections. Monthly temperature and precipitation, wintertime 500hPa geopotential height, and the previous year's yield are used as predictors to forecast spring wheat yield in advance. Canadian small agricultural divisions (SAD) are used for analysis. Each SAD is composed of a collection of Canadian Agricultural Regions (CAR) of similar weather and growing conditions. Spring wheat yields in each CAR are forecast from the following variables: (a) the previous year's yield, (b) earlier stages of the growing season's climate conditions and, (c) the previous year's wintertime northern hemisphere 500hPa geopotential height field. Arctic outflow events in the Okanagan Valley in Canada are associated with episodes of extremely low temperatures during wintertime. Principal component analysis (PCA) is applied for wintertime northern hemisphere 500hPa geopotential height anomalies. The spatial PCA mode1 is defined as Arctic Oscillation and it influences prevailing westerlies. The prevailing westerlies meanders and influences climatic conditions. The spatial similarity between wintertime top 5 Arctic outflow event year's composites of 500hPa geopotential height anomalies and mode 3's spatial pattern is found. Mode 3's spatial pattern looks like the Pacific/North American (PNA) pattern which describes the variation of atmospheric circulation pattern over the Pacific Ocean and North America. Climate conditions from April to June, May to July, mode 3's time coefficients, and previous year's yield are used for forecasting spring wheat yield in each SAD. Cross-validation procedure which generates eight sets of models for the eight

  18. BLOCK TEACHING PROJECT, INTEGRATING HUMANITIES AND SOCIAL SCIENCE, FINAL REPORT.

    ERIC Educational Resources Information Center

    KREISMAN, ARTHUR

    A BLOCK TEACHING PROJECT BRINGING TOGETHER 100 STUDENTS AND 7 FACULTY MEMBERS, COVERING 6 AREAS OF SUBJECT MATTER FOR A TOTAL OF 12 CREDIT HOURS PER QUARTER FOR 3 QUARTERS, WAS SET UP. THE SUBJECT MATTER WAS MADE UP OF HISTORY OF WESTERN CIVILIZATION (3 CREDIT HOURS PER QUARTER), WORLD LITERATURE (3 CREDIT HOURS PER QUARTER), ENGLISH COMPOSITION…

  19. Convective heat transfer area of the human body.

    PubMed

    Kurazumi, Yoshihito; Tsuchikawa, Tadahiro; Matsubara, Naoki; Horikoshi, Tetsumi

    2004-12-01

    In order to clarify the heat transfer area involved in convective heat exchange for the human body, the total body surface area of six healthy subjects was measured, and the non-convective heat transfer area and floor and chair contact areas for the following nine common body positions were measured: standing, sitting on a chair, sitting in the seiza position, sitting cross-legged, sitting sideways, sitting with both knees erect, sitting with a leg out, and the lateral and supine positions. The main non-convective heat transfer areas were: the armpits (contact between the upper arm and trunk regions), contact between the two legs, contacts between the fingers and toes, and contact between the hands and the body surface. Also, when sitting on the floor with some degree of leg contact (sitting in the seiza position, cross-legged, or sideways), there was a large non-convective heat transfer area on the thighs and legs. Even when standing or sitting in a chair, about 6-8% of the body surface did not transfer heat by convection. The results showed that the effective thermal convective area factor for the naked whole body in the standing position was 0.942. While sitting in a chair this factor was 0.860, while sitting in a chair but excluding the chair contact area it was 0.918, when sitting in the seiza position 0.818, when sitting cross-legged 0.843, in the sideways sitting position 0.855, when sitting with both knees erect 0.887, in the leg-out sitting position 0.906, while in the lateral position it was 0.877 and the supine position 0.844. For all body positions, the effective thermal convective area factor was greater than the effective thermal radiation area factor, but smaller than the total body surface area.

  20. The Human Homologue of Macaque Area V6A

    PubMed Central

    Pitzalis, S.; Sereno, M.I.; Committeri, G.; Fattori, P.; Galati, G.; Tosoni, A.; Galletti, C.

    2013-01-01

    In macaque monkeys, V6A is a visuomotor area located in the anterior bank of the POs, dorsal and anterior to retinotopically-organized extrastriate area V6 (Galletti et al 1996). Unlike V6, V6A represents both contra- and ipsilateral visual fields and is broadly retinotopically organized (Galletti et al 1999b). The contralateral lower visual field is overrepresented in V6A. The central 20°–30° of the visual field are mainly represented dorsally (V6Ad) and the periphery ventrally (V6Av), at the border with V6. Both sectors of area V6A contain arm movement-related cells, active during spatially-directed reaching movements (Gamberini et al., 2011). In humans, we previously mapped the retinotopic organization of area V6 (Pitzalis et al., 2006). Here, using phase-encoded fMRI, cortical surface-based analysis and wide-field retinotopic mapping, we define a new cortical region that borders V6 anteriorly and shows a clear over-representation of the contralateral lower visual field and of the periphery. As with macaque V6A, the eccentricity increases moving ventrally within the area. The new region contains a non-mirror-image representation of the visual field. Functional mapping reveals that, as in macaque V6A, the new region, but not the nearby area V6, responds during finger pointing and reaching movements. Based on similarity in position, retinotopic properties, functional organization and relationship with the neighbouring extrastriate visual areas, we propose that the new cortical region is the human homologue of macaque area V6A. PMID:23770406

  1. The visual pulvinar in tree shrews II. Projections of four nuclei to areas of visual cortex.

    PubMed

    Lyon, David C; Jain, Neeraj; Kaas, Jon H

    2003-12-22

    Patterns of thalamocortical connections were related to architectonically defined subdivisions of the pulvinar complex and the dorsolateral geniculate nucleus (LGN) in tree shrews (Tupaia belangeri). Tree shrews are of special interest because they are considered close relatives of primates, and they have a highly developed visual system. Several distinguishable tracers were injected within and across cortical visual areas in individual tree shrews in order to reveal retinotopic patterns and cortical targets of subdivisions of the pulvinar. The results indicate that each of the three architectonic regions of the pulvinar has a distinctive pattern of cortical connections and that one of these divisions is further divided into two regions with different patterns of connections. Two of the pulvinar nuclei have similar retinotopic patterns of projections to caudal visual cortex. The large central nucleus of the pulvinar (Pc) projects to the first and second visual areas, V1 and V2, and an adjoining temporal dorsal area (TD) in retinotopic patterns indicating that the upper visual quadrant is represented dorsal to the lower quadrant in Pc. The smaller ventral nucleus (Pv) which stains darkly for the Cat-301 antigen, projects to these same cortical areas, with a retinotopic pattern. Pv also projects to a temporal anterior area, TA. The dorsal nucleus (Pd), which densely expresses AChE, projects to posterior and ventral areas of temporal extrastriate cortex, areas TP and TPI. A posterior nucleus, Pp, projects to anterior areas TAL and TI, of the temporal lobe, as well as TPI. Injections in different cortical areas as much as 6 mm apart labeled overlapping zones in Pp and double-labeled some cells. These results indicate that the visual pulvinar of tree shrews contains at least four functionally distinct subdivisions, or nuclei. In addition, the cortical injections revealed that the LGN projects topographically and densely to V1 and that a significant number of LGN neurons

  2. Sustaining Jamaica's forests: The protected areas resource conservation project

    NASA Astrophysics Data System (ADS)

    Berke, Philip R.; Beatley, Timothy

    1995-07-01

    This study examines Jamaica's attempt to protect a tropical forest reserve. The biophysical setting, and the types and magnitude of forest development pressures are reviewed. Next, Jamaica's approach to developing new land-use strategies and compatible environmental protection and economic development programs are examined. Finally, the practical and theoretical implications by which institutions can be designed to encourage planning for sustainable development are reviewed. The implications suggest how to provide an appropriate mix of cooperation and market competition, by which people acting in their own interests accomplish socially equitable economic development, while protecting the environment for the benefit of future generations. The experience illustrates that effective long-term protection of natural areas requires the building of local relationships and support, the development of local economic activities supportive of conservation, the defining of clear boundaries, and significant monitoring and enforcement. Long-term protection of the Blue and John Crow mountains, and other important natural areas of Jamaica, will also require the development of a workable and enforceable system of land-use planning for the island, and adjustments to the economic incentive structure so that sustainable, nonextractive uses of natural capital are placed on equal footing with other economic uses (e.g., coffee production).

  3. The mitochondrial Italian Human Proteome Project initiative (mt-HPP).

    PubMed

    Urbani, Andrea; De Canio, Michele; Palmieri, Ferdinando; Sechi, Salvatore; Bini, Luca; Castagnola, Massimo; Fasano, Mauro; Modesti, Alessandra; Roncada, Paola; Timperio, Anna Maria; Bonizzi, Luigi; Brunori, Maurizio; Cutruzzolà, Francesca; De Pinto, Vito; Di Ilio, Carmine; Federici, Giorgio; Folli, Franco; Foti, Salvatore; Gelfi, Cecilia; Lauro, Davide; Lucacchini, Antonio; Magni, Fulvio; Messana, Irene; Pandolfi, Pier Paolo; Papa, Sergio; Pucci, Piero; Sacchetta, Paolo

    2013-08-01

    Mitochondria carry maternally inherited genetic material, called the mitochondrial genome (mtDNA), which can be defined as the 25th human chromosome. The chromosome-centric Human Proteome Project (c-HPP) has initially focused its activities addressing the characterization and quantification of the nuclear encoded proteins. Following the last International HUPO Congress in Boston (September 2012) it was clear that however small the mitochondrial chromosome is, it plays an important role in many biological and physiopathological functions. Mutations in the mtDNA have been shown to be associated with dozens of unexplained disorders and the information contained in the mtDNA should be of major relevance to the understanding of many human diseases. Within this paper we describe the Italian initiative of the Human Proteome Project dedicated to mitochondria as part of both programs: chromosome-centric (c-HPP) and Biology/Disease (B/D-HPP). The mt-HPP has finally shifted the attention of the HUPO community outside the nuclear chromosomes with the general purpose to highlight the mitochondrial processes influencing the human health. Following this vision and considering the large interest and evidence collected on the non-Mendelian heredity of Homo sapiens associated with mt-chromosome and with the microbial commensal ecosystem constituting our organism we may speculate that this program will represent an initial step toward other HPP initiatives focusing on human phenotypic heredity.

  4. The Human Eye Proteome Project: perspectives on an emerging proteome.

    PubMed

    Semba, Richard D; Enghild, Jan J; Venkatraman, Vidya; Dyrlund, Thomas F; Van Eyk, Jennifer E

    2013-08-01

    There are an estimated 285 million people with visual impairment worldwide, of whom 39 million are blind. The pathogenesis of many eye diseases remains poorly understood. The human eye is currently an emerging proteome that may provide key insight into the biological pathways of disease. We review proteomic investigations of the human eye and present a catalogue of 4842 nonredundant proteins identified in human eye tissues and biofluids to date. We highlight the need to identify new biomarkers for eye diseases using proteomics. Recent advances in proteomics do now allow the identification of hundreds to thousands of proteins in tissues and fluids, characterization of various PTMs and simultaneous quantification of multiple proteins. To facilitate proteomic studies of the eye, the Human Eye Proteome Project (HEPP) was organized in September 2012. The HEPP is one of the most recent components of the Biology/Disease-driven Human Proteome Project (B/D-HPP) whose overarching goal is to support the broad application of state-of-the-art measurements of proteins and proteomes by life scientists studying the molecular mechanisms of biological processes and human disease. The large repertoire of investigative proteomic tools has great potential to transform vision science and enhance understanding of physiology and disease processes that affect sight.

  5. Archeological Investigations in the Lower Pool Area of the La Farge Lake Project Area,

    DTIC Science & Technology

    This is the area which would be flooded if aa cofferdam were built to enable the completion of the proposed Kickapoo dam. The Lower Pool area was...to the National Register of Historic Places. These sites have potential for yielding valuable archaeological information which would enhance our understanding of prehistoric settlement in the Upper Kickapoo Valley. (Author)

  6. 7. Photocopy of engineering drawing. PROJECT WS315A HELIUM STORAGE AREA: ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Photocopy of engineering drawing. PROJECT WS-315A HELIUM STORAGE AREA: PLAN AND DETAILS-MECHANICAL, APRIL 1956. - Cape Canaveral Air Station, Launch Complex 17, Facility 28419, East end of Lighthouse Road, Cape Canaveral, Brevard County, FL

  7. Linking with Community To Reclaim Natural Areas for Education: The McLane Elementary School Project.

    ERIC Educational Resources Information Center

    Spencer, Melinda; Smith, Kathy Kurtz

    2002-01-01

    Describes a project in which students, teachers, and the community work to reclaim neglected wetlands and forested areas for use as an environmental study site for interdisciplinary learning. (Author/MM)

  8. The National Map - Lake Tahoe Area Pilot Project

    USGS Publications Warehouse

    ,

    2001-01-01

    Governments depend on a common set of geographic base information as a tool for economic and community development, land and natural resource management, and health and safety services. Emergency management and defense operations rely on this information. Private industry, nongovernmental organizations, and individual citizens use the same geographic data. Geographic information underpins an increasingly large part of the Nation's economy. Available geographic data often have the following problems: * They do not align with each other because layers are frequently created or revised separately, * They do not match across administrative boundaries because each producing organization uses different methods and standards, and * They are not up to date because of the complexity and cost of revision. The U.S. Geological Survey (USGS) is developing The National Map to be a seamless, continuously maintained, and nationally consistent set of online, public domain, geographic base information to address these issues. The National Map will serve as a foundation for integrating, sharing, and using other data easily and consistently. In collaboration with other government agencies, the private sector, academia, and volunteer groups, the USGS will coordinate, integrate, and, where needed, produce and maintain base geographic data. The National Map will include digital orthorectified imagery; elevation data; vector data for hydrography, transportation, boundary, and structure features; geographic names; and land cover information. The data will be the source of revised paper topographic maps. Many technical and institutional issues must be resolved as The National Map is implemented. To begin the refinement of this new paradigm, pilot projects are being designed to identify and investigate these issues. The pilots are the foundation upon which future partnerships for data sharing and maintenance will be built.

  9. Research, demonstration, and extension: the ARS area-wide ecologically based invasive plant management project

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Area-wide project is a collaborative five year effort funded in 2008 by USDA-ARS that has brought together scientists with the USDA-ARS, universities, land managers, and policy makers throughout the Great Basin. A primary goal of the project is to develop and implement a comprehensive, regional...

  10. Project MACTAD, Mobile Area Committee for Training and Development. Periodic Report.

    ERIC Educational Resources Information Center

    Gilliard, R.W.; And Others

    The project was created to train the unemployed and underemployed in the Mobile area in skills qualifying them for jobs in Alabama's expanding industrial complex. Developments in the administration, recruiting, counseling, community service, training, job development and placement, and followup of the project from January 1, 1968 through February…

  11. A Project for Everyone: English Language Learners and Technology in Content-Area Classrooms.

    ERIC Educational Resources Information Center

    Egbert, Joy

    2002-01-01

    Discussion of student participation in classroom projects when learning English as a second language highlights conditions that support language and content learning; approaches that can facilitate language and content learning; and what technology and other resources support English language learners in content-area classrooms. Uses a project on…

  12. Aberdeen Area Final Evaluation Report, ESEA Title I Projects, Fiscal Year 1976.

    ERIC Educational Resources Information Center

    Bureau of Indian Affairs (Dept. of Interior), Aberdeen, SD. Aberdeen Area Office.

    The final evaluation report on the 37 Elementary Secondary Education Act (ESEA) Title I projects in the Bureau of Indian Affairs (BIA) Aberdeen Area, this report presents graphic and tabular descriptions for each of the 37 projects re: (1) Title I expenditures (graphic display of expenditures for reading, math, language, administration, area…

  13. USDA area-wide project for annual grasses: outcomes and impacts

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This document provides a record of the research, outreach, education and technology transfer that was completed as part of the area-wide project for invasive annual grasses from 2007-2012. The overall goal of the project was to catalyze a holistic integrated management program for invasive annual g...

  14. Fluid Management Plan for Corrective Action Unit 447: Project Shoal Area, Subsurface, Nevada, Rev. No.: 1

    SciTech Connect

    Findlay, Rick

    2006-01-01

    The U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (NNSA/NSO) initiated the Offsites Project to characterize the risk posed to human health and the environment as a result of testing at formerly used nuclear sites in Alaska, Colorado, Mississippi, Nevada, and New Mexico. The scope of this Fluid Management Plan (FMP) is to support the subsurface investigation at the Project Shoal Area (PSA) Corrective Action Unit (CAU) 447, Shoal - Subsurface, Nevada, in accordance with the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996). Corrective Action Unit 447 is located in the Sand Spring Range, south of Highway 50, about 39 miles southeast of Fallon, Nevada. (Figure 1-1). This FMP will be used at the PSA in lieu of an individual discharge permit for each well or a general water pollution control permit for management of all fluids produced during the drilling, construction, development, testing, experimentation, and/or sampling of wells conducted by the Offsites Project. The FMP provides guidance for the management of fluids generated during investigation activities and provides the standards by which fluids may be discharged on site. Although the Nevada Division of Environmental Protection (NDEP), Bureau of Federal Facilities (BoFF) is not a signatory to this FMP, it is involved in the negotiation of the contents of this plan and approves the conditions contained within. The major elements of this FMP include: (1) establishment of a well-site operations strategy; (2) site design/layout; (3) monitoring of contamination indicators (monitoring program); (4) sump characterization (sump sampling program); (5) fluid management decision criteria and fluid disposition; and (6) reporting requirements.

  15. Test Area North Pool Stabilization Project: Environmental assessment

    SciTech Connect

    1996-05-01

    The Test Area North (TAN) Pool is located within the fenced TAN facility boundaries on the Idaho National Engineering Laboratory (INEL). The TAN pool stores 344 canisters of core debris from the March, 1979, Three Mile Island (TMI) Unit 2 reactor accident; fuel assemblies from Loss-of-Fluid Tests (LOFT); and Government-owned commercial fuel rods and assemblies. The LOFT and government owned commercial fuel rods and assemblies are hereafter referred to collectively as {open_quotes}commercial fuels{close_quotes} except where distinction between the two is important to the analysis. DOE proposes to remove the canisters of TMI core debris and commercial fuels from the TAN Pool and transfer them to the Idaho Chemical Processing Plant (ICPP) for interim dry storage until an alternate storage location other than at the INEL, or a permanent federal spent nuclear fuel (SNF) repository is available. The TAN Pool would be drained and placed in an industrially and radiologically safe condition for refurbishment or eventual decommissioning. This environmental assessment (EA) identifies and evaluates environmental impacts associated with (1) constructing an Interim Storage System (ISS) at ICPP; (2) removing the TMI and commercial fuels from the pool and transporting them to ICPP for placement in an ISS, and (3) draining and stabilizing the TAN Pool. Miscellaneous hardware would be removed and decontaminated or disposed of in the INEL Radioactive Waste Management Complex (RWMC). This EA also describes the environmental consequences of the no action alternative.

  16. The Human Genome Project: ethical and social implications.

    PubMed

    Murray, T H; Livny, E

    1995-01-01

    This article explores some of the potential moral and social ramifications of the Human Genome Project. Research on the human genome is generating important ethical and social questions of at least three distinct kinds. First, what genetic information should be generated, and who should control its dissemination and use? Improved diagnostic techniques such as presymptomatic testing, carrier screening, and prenatal screening can provide information that poses significant ethical problems for individuals, employers and insurance companies, and the medical and counseling professions. Second, what genetic procedures should be employed? The burgeoning ability to manipulate human genotypes and phenotypes through procedures such as gene therapy and enzyme therapy are leading to difficult questions about which manipulations should be permitted and which should be prohibited. Third, how will this new information change lives? Increasing claims about the relationship of genetics to ethically and politically significant traits and behaviors are challenging human self-understanding and the capacity of social institutions to respond adequately.

  17. The Human Genome Project: ethical and social implications.

    PubMed Central

    Murray, T H; Livny, E

    1995-01-01

    This article explores some of the potential moral and social ramifications of the Human Genome Project. Research on the human genome is generating important ethical and social questions of at least three distinct kinds. First, what genetic information should be generated, and who should control its dissemination and use? Improved diagnostic techniques such as presymptomatic testing, carrier screening, and prenatal screening can provide information that poses significant ethical problems for individuals, employers and insurance companies, and the medical and counseling professions. Second, what genetic procedures should be employed? The burgeoning ability to manipulate human genotypes and phenotypes through procedures such as gene therapy and enzyme therapy are leading to difficult questions about which manipulations should be permitted and which should be prohibited. Third, how will this new information change lives? Increasing claims about the relationship of genetics to ethically and politically significant traits and behaviors are challenging human self-understanding and the capacity of social institutions to respond adequately. PMID:7703933

  18. Project NO REST: Addressing Human Trafficking in North Carolina.

    PubMed

    Duncan, Dean F

    Project NO REST (North Carolina Organizing and Responding to the Exploitation and Sexual Trafficking of Children) is a 5-year effort funded by the US Children's Bureau to address the trafficking of individuals age 25 years and younger in North Carolina. The project aims to increase awareness of human trafficking affecting children and youth, especially those in the child welfare system; to reduce the number of these youth who are trafficked; and to improve outcomes for those who are trafficked. In the project's first year, nearly 100 stakeholders statewide developed a comprehensive plan to address trafficking. Later, 5 communities were recruited to implement the plan at the local level. Their experiences will be used to develop a toolkit for future anti-trafficking efforts.

  19. Observed and Projected Climate Extremities in Chennai Metropolitan Area

    NASA Astrophysics Data System (ADS)

    Anushiya, j.; Andimuthu, R.

    2013-12-01

    Analyses of observed climate throughout world revealed some significant changes in the extremes. Any change in the frequency or severity of extreme climate events would have profound impacts on the resilience of nature and society. It is thus very important to analyze extreme events to reliably monitor and detect climate change. Chennai is the fourth largest metropolis in India and one of the fastest growing economic and Industrial growth centers in South Asia. Population has grown rapidly in the last 20 years due to its major industrialization and tremendous growth. Already Chennai's day and night time Temperature shows an increasing trend. The past incidence of catastrophic flooding was observed in the city due to heavy rains associated with depressions and cyclonic storm lead floods in major rivers. After 2000, the incidents were reported repeatedly. The effort has made in this study to find the observed climate extremities over the past years and in the future. For observed changes, IMD gridded data set, and station data are used. Future high resolution climate scenarios (0.220x0.220) are developed through RCM using PRECIS. The boundary data have provided by the UK Met office. The selected members are simulated under the A1B scenario (a mid range emission scenario) for a continuous run till 2100. Climate indices listed by Expert Team (ET) on Climate Change Detection and Indices (ETCCDI) by the CLIVAR are considered in this study. The indices were obtained using the software package RClimDex. Kendall's tau based slope estimator has been used to find the significance lavel. The results shows the significant increasing tendency of warm days (TX90P) in the past and in future. The trends in extreme wet days (R99P) are also increased. The growth in population, urban and industrial area, economic activities, depletion of natural resources along with changing climate are forced to develop the infrastructure includes climate friendly policies to adopt and to ensure the

  20. NASA Technology Area 07: Human Exploration Destination Systems Roadmap

    NASA Technical Reports Server (NTRS)

    Kennedy, Kriss J.; Alexander, Leslie; Landis, Rob; Linne, Diane; Mclemore, Carole; Santiago-Maldonado, Edgardo; Brown, David L.

    2011-01-01

    This paper gives an overview of the National Aeronautics and Space Administration (NASA) Office of Chief Technologist (OCT) led Space Technology Roadmap definition efforts. This paper will given an executive summary of the technology area 07 (TA07) Human Exploration Destination Systems (HEDS). These are draft roadmaps being reviewed and updated by the National Research Council. Deep-space human exploration missions will require many game changing technologies to enable safe missions, become more independent, and enable intelligent autonomous operations and take advantage of the local resources to become self-sufficient thereby meeting the goal of sustained human presence in space. Taking advantage of in-situ resources enhances and enables revolutionary robotic and human missions beyond the traditional mission architectures and launch vehicle capabilities. Mobility systems will include in-space flying, surface roving, and Extra-vehicular Activity/Extravehicular Robotics (EVA/EVR) mobility. These push missions will take advantage of sustainability and supportability technologies that will allow mission independence to conduct human mission operations either on or near the Earth, in deep space, in the vicinity of Mars, or on the Martian surface while opening up commercialization opportunities in low Earth orbit (LEO) for research, industrial development, academia, and entertainment space industries. The Human Exploration Destination Systems (HEDS) Technology Area (TA) 7 Team has been chartered by the Office of the Chief Technologist (OCT) to strategically roadmap technology investments that will enable sustained human exploration and support NASA s missions and goals for at least the next 25 years. HEDS technologies will enable a sustained human presence for exploring destinations such as remote sites on Earth and beyond including, but not limited to, LaGrange points, low Earth orbit (LEO), high Earth orbit (HEO), geosynchronous orbit (GEO), the Moon, near

  1. Human genome project: revolutionizing biology through leveraging technology

    NASA Astrophysics Data System (ADS)

    Dahl, Carol A.; Strausberg, Robert L.

    1996-04-01

    The Human Genome Project (HGP) is an international project to develop genetic, physical, and sequence-based maps of the human genome. Since the inception of the HGP it has been clear that substantially improved technology would be required to meet the scientific goals, particularly in order to acquire the complete sequence of the human genome, and that these technologies coupled with the information forthcoming from the project would have a dramatic effect on the way biomedical research is performed in the future. In this paper, we discuss the state-of-the-art for genomic DNA sequencing, technological challenges that remain, and the potential technological paths that could yield substantially improved genomic sequencing technology. The impact of the technology developed from the HGP is broad-reaching and a discussion of other research and medical applications that are leveraging HGP-derived DNA analysis technologies is included. The multidisciplinary approach to the development of new technologies that has been successful for the HGP provides a paradigm for facilitating new genomic approaches toward understanding the biological role of functional elements and systems within the cell, including those encoded within genomic DNA and their molecular products.

  2. Corrective action investigation plan for Project Shoal Area CAU No. 416

    SciTech Connect

    1996-08-01

    This Corrective Action Investigation Plan (CAIP) is part of an ongoing US Department of Energy (DOE)-funded project for the investigation of Corrective Action Unit (CAU) No. 416, Project Shoal Area (PSA). Project Shoal was conducted to determine whether seismic waves produced by underground nuclear testing could be differentiated from naturally occurring earthquakes. The PSA site is located approximately 30 miles southeast of Fallon, Nevada, in the northern portion of Sand Springs Mountains in Churchill County. This CAIP will be implemented in accordance with the Federal Facility Agreement and Consent Order, the Industrial Sites Quality Assurance Project Plan, and all applicable Nevada Division of Environmental Protection policies and regulations.

  3. Underground Test Area Quality Assurance Project Plan Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Irene Farnham

    2011-05-01

    This Quality Assurance Project Plan (QAPP) provides the overall quality assurance (QA) program requirements and general quality practices to be applied to the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (NNSA/NSO) Underground Test Area (UGTA) Sub-Project (hereafter the Sub-Project) activities. The requirements in this QAPP are consistent with DOE Order 414.1C, Quality Assurance (DOE, 2005); U.S. Environmental Protection Agency (EPA) Guidance for Quality Assurance Project Plans for Modeling (EPA, 2002); and EPA Guidance on the Development, Evaluation, and Application of Environmental Models (EPA, 2009). The QAPP Revision 0 supersedes DOE--341, Underground Test Area Quality Assurance Project Plan, Nevada Test Site, Nevada, Revision 4.

  4. Assessing human rights impacts in corporate development projects

    SciTech Connect

    Salcito, Kendyl; Utzinger, Jürg; Weiss, Mitchell G.; Münch, Anna K.; Singer, Burton H.; Krieger, Gary R.; Wielga, Mark

    2013-09-15

    Human rights impact assessment (HRIA) is a process for systematically identifying, predicting and responding to the potential impact on human rights of a business operation, capital project, government policy or trade agreement. Traditionally, it has been conducted as a desktop exercise to predict the effects of trade agreements and government policies on individuals and communities. In line with a growing call for multinational corporations to ensure they do not violate human rights in their activities, HRIA is increasingly incorporated into the standard suite of corporate development project impact assessments. In this context, the policy world's non-structured, desk-based approaches to HRIA are insufficient. Although a number of corporations have commissioned and conducted HRIA, no broadly accepted and validated assessment tool is currently available. The lack of standardisation has complicated efforts to evaluate the effectiveness of HRIA as a risk mitigation tool, and has caused confusion in the corporate world regarding company duties. Hence, clarification is needed. The objectives of this paper are (i) to describe an HRIA methodology, (ii) to provide a rationale for its components and design, and (iii) to illustrate implementation of HRIA using the methodology in two selected corporate development projects—a uranium mine in Malawi and a tree farm in Tanzania. We found that as a prognostic tool, HRIA could examine potential positive and negative human rights impacts and provide effective recommendations for mitigation. However, longer-term monitoring revealed that recommendations were unevenly implemented, dependent on market conditions and personnel movements. This instability in the approach to human rights suggests a need for on-going monitoring and surveillance. -- Highlights: • We developed a novel methodology for corporate human rights impact assessment. • We piloted the methodology on two corporate projects—a mine and a plantation. • Human

  5. A Computer Program for Projections of Vehicular Pollutant Emissions in Urban Areas

    ERIC Educational Resources Information Center

    Sauter, G. D.; Ott, W. R.

    1974-01-01

    Describes an algorithm for the determination of current and projected annual air pollution emissions from vehicles in any urban area. A computer program based on this algorithm, PAVE, has been developed. Results of applying the program to emissions from automobiles in the San Francisco Bay Area are presented and discussed. (Editor/JR)

  6. Cortical projection topography of the human splenium: hemispheric asymmetry and individual differences.

    PubMed

    Putnam, Mary Colvin; Steven, Megan S; Doron, Karl W; Riggall, Adam C; Gazzaniga, Michael S

    2010-08-01

    The corpus callosum is the largest white matter pathway in the human brain. The most posterior portion, known as the splenium, is critical for interhemispheric communication between visual areas. The current study employed diffusion tensor imaging to delineate the complete cortical projection topography of the human splenium. Homotopic and heterotopic connections were revealed between the splenium and the posterior visual areas, including the occipital and the posterior parietal cortices. In nearly one third of participants, there were homotopic connections between the primary visual cortices, suggesting interindividual differences in splenial connectivity. There were also more instances of connections with the right hemisphere, indicating a hemispheric asymmetry in interhemispheric connectivity within the splenium. Combined, these findings demonstrate unique aspects of human interhemispheric connectivity and provide anatomical bases for hemispheric asymmetries in visual processing and a long-described hemispheric asymmetry in speed of interhemispheric communication for visual information.

  7. Specificity of human cortical areas for reaches and saccades

    PubMed Central

    Levy, Ifat; Schluppeck, Denis; Heeger, David J.; Glimcher, Paul W.

    2007-01-01

    Electrophysiological studies in monkeys have identified effector-related regions in the posterior parietal cortex (PPC). The lateral intraparietal area (LIP), for example, responds preferentially for saccades whereas the parietal reach region (PRR) responds preferentially for arm movements. However, the degree of effector selectivity actually observed is limited; each area contains neurons selective for the non-preferred effector, and many neurons in both areas respond for both effectors. We used fMRI to assess the degree of effector preference at the population level, focusing on topographically organized regions in the human PPC (V7, IPS1 and IPS2). An event-related design adapted from monkey experiments was employed. In each trial, an effector cue preceded the appearance of a spatial target, after which a go-signal instructed subjects to produce the specified movement with the specified effector. Our results show that the degree of effector specificity is limited in many cortical areas, and transitions gradually from saccade to reach preference as one moves through the hierarchy of areas in the occipital, parietal, and frontal cortices. Saccade preference was observed in visual cortex, including early areas and V7. IPS1 exhibited balanced activation to saccades and reaches, whereas IPS2 showed a weak but significant preference for reaches. In frontal cortex, areas near the central sulcus showed a clear and absolute preference for reaches while the Frontal Eye Field (FEF) showed little or no effector selectivity. Although these results contradict many theoretical conclusions about effector specificity, they are compatible with the complex picture arising from electrophysiological studies and also with previous imaging studies that reported largely overlapping saccade and arm related activation. The results are also compatible with theories of efficient coding in cortex. PMID:17460081

  8. A Novel Human Body Area Network for Brain Diseases Analysis.

    PubMed

    Lin, Kai; Xu, Tianlang

    2016-10-01

    Development of wireless sensor and mobile communication technology provide an unprecedented opportunity for realizing smart and interactive healthcare systems. Designing such systems aims to remotely monitor the health and diagnose the diseases for users. In this paper, we design a novel human body area network for brain diseases analysis, which is named BABDA. Considering the brain is one of the most complex organs in the human body, the BABDA system provides four function modules to ensure the high quality of the analysis result, which includes initial data collection, data correction, data transmission and comprehensive data analysis. The performance evaluation conducted in a realistic environment with several criteria shows the availability and practicability of the BABDA system.

  9. Human impact on the coastal area of Ishem -Shengjin

    NASA Astrophysics Data System (ADS)

    Dollma, Merita

    2010-05-01

    Human impact on the coastal area of Ishem -Shengjin This paper is about the natural and human factors role impact on the geomorphology of the coastal area of Ishem -Shengjin. The morphotectonic and morphologic evolution of this zone is closely connected to the Adriatic sea and Mat, Ishem rivers activities. An important role in this evolution has also played the tectonic faults, where Mat and Ishem rivers flow. River delta advancing in this zone, besides the littoral cordons, is connected to the river solid loads (about 5380 ton/km2), which manage to compensate the continuous tectonic subsidents of its structural basement. The presence of the lagoons (Patok, Merxhan, Ceka), dead meanders and marshlands along a distance of 2-4 km of this zone, are the evidences of continues morphologic evolution of the present coastline, especially between these two rivers. The higher tectonic subsident values of the basement along Mat fault have also defined the smaller size of the alluvial field of this river compare to the alluvial field created by Ishem river. This tectonic phenomena is evidenced with the different thickness of the quaternary depositions along the Ishem river sector (30-80m) and along Mati river (250-290 m). Human impact on the geomorphologic evolution of this zone has caused the total destruction of Patok beach, due to the deviation of the Ishem river flow to the lagoon of Patok. The creation of the artificial reservoirs along Mat river (Ulez, Shkopet) and Ishem river (Bovilla), besides the extraction of the river inert materials along Mati riverbed and destruction of the river banks concretes, have decreased the solid river load. This has caused the beginning of the erosion process of the coastline in some sectors of this zone. Consequently the damages on the natural environment of this zone caused by the human impact are severe and their rehabilitation and management needs an integrated approach from different actors.

  10. Human factors in aviation: Terminal control area boundary conflicts

    NASA Technical Reports Server (NTRS)

    Monan, William P.

    1989-01-01

    Air-to-air conflicts in the vicinity of Terminal Control Area (TCA) boundaries were studied to obtain a better understanding of the causal dynamics of these events with particular focus on human factor issues. The study dataset consisted of 381 Instrument Flight Rules/Visual Flight Rules (IFR/VFR) traffic conflicts in airspace layers above TCA ceiling and below TCA floors; 213 reports of incursions in TCA terminal airspace by VFR aircraft, of which 123 resulted in conflicts; and an additional set of reports describing problems with Air Traffic Control (ATC) services in and around TCAs. Results and conclusions are detailed.

  11. The software analysis project for the Office of Human Resources

    NASA Technical Reports Server (NTRS)

    Tureman, Robert L., Jr.

    1994-01-01

    There were two major sections of the project for the Office of Human Resources (OHR). The first section was to conduct a planning study to analyze software use with the goal of recommending software purchases and determining whether the need exists for a file server. The second section was analysis and distribution planning for retirement planning computer program entitled VISION provided by NASA Headquarters. The software planning study was developed to help OHR analyze the current administrative desktop computing environment and make decisions regarding software acquisition and implementation. There were three major areas addressed by the study: current environment new software requirements, and strategies regarding the implementation of a server in the Office. To gather data on current environment, employees were surveyed and an inventory of computers were produced. The surveys were compiled and analyzed by the ASEE fellow with interpretation help by OHR staff. New software requirements represented a compilation and analysis of the surveyed requests of OHR personnel. Finally, the information on the use of a server represents research done by the ASEE fellow and analysis of survey data to determine software requirements for a server. This included selection of a methodology to estimate the number of copies of each software program required given current use and estimated growth. The report presents the results of the computing survey, a description of the current computing environment, recommenations for changes in the computing environment, current software needs, management advantages of using a server, and management considerations in the implementation of a server. In addition, detailed specifications were presented for the hardware and software recommendations to offer a complete picture to OHR management. The retirement planning computer program available to NASA employees will aid in long-range retirement planning. The intended audience is the NASA civil

  12. Bear Creek Valley characterization area mixed wastes passive in situ treatment technology demonstration project - status report

    SciTech Connect

    Watson, D.; Leavitt, M.; Moss, D.

    1997-03-01

    Historical waste disposal activities within the Bear Creek Valley (BCV) Characterization Area (CA), at the U.S. Department of Energy (DOE) Oak Ridge Y-12 plant, have contaminated groundwater and surface water above human health risk levels and impacted the ecology of Bear Creek. Contaminates include nitrate, radioisotopes, metals, volatile organic chemicals (VOCS), and common ions. This paper provides a status report on a technology demonstration project that is investigating the feasibility of using passive in situ treatment systems to remove these contaminants. Although this technology may be applicable to many locations at the Oak Ridge Y-12 Plant, the project focuses on collecting the information needed to take CERCLA removal actions in 1998 at the S-3 Disposal Ponds site. Phase 1 has been completed and included site characterization, laboratory screening of treatment media (sorbents; and iron), and limited field testing of biological treatment systems. Batch tests using different Y-12 Plant waters were conducted to evaluate the removal efficiencies of most of the media. Phase 1 results suggest that the most promising treatment media are Dowex 21 k resin, peat moss, zero-valent iron, and iron oxides. Phase 2 will include in-field column testing of these media to assess loading rates, and concerns with clogging, by-products, and long-term treatment efficiency and media stability. Continued testing of wetlands and algal mats (MATs) will be conducted to determine if they can be used for in-stream polishing of surface water. Hydraulic testing of a shallow trench and horizontal well will also be completed during Phase 2. 4 refs., 3 tabs.

  13. Rainwater Wildlife Area, Watershed Management Plan, A Columbia Basin Wildlife Mitigation Project, 2002.

    SciTech Connect

    Childs, Allen B.

    2002-03-01

    This Management Plan has been developed by the Confederated Tribes of the Umatilla Indian Reservation (CTUIR) to document how the Rainwater Wildlife Area (formerly known as the Rainwater Ranch) will be managed. The plan has been developed under a standardized planning process developed by the Bonneville Power Administration (BPA) for Columbia River Basin Wildlife Mitigation Projects (See Appendix A and Guiding Policies Section below). The plan outlines the framework for managing the project area, provides an assessment of existing conditions and key resource issues, and presents an array of habitat management and enhancement strategies. The plan culminates into a 5-Year Action Plan that will focus our management actions and prioritize funding during the Fiscal 2001-2005 planning period. This plan is a product of nearly two years of field studies and research, public scoping, and coordination with the Rainwater Advisory Committee. The committee consists of representatives from tribal government, state agencies, local government, public organizations, and members of the public. The plan is organized into several sections with Chapter 1 providing introductory information such as project location, purpose and need, project goals and objectives, common elements and assumptions, coordination efforts and public scoping, and historical information about the project area. Key issues are presented in Chapter 2 and Chapter 3 discusses existing resource conditions within the wildlife area. Chapter 4 provides a detailed presentation on management activities and Chapter 5 outlines a monitoring and evaluation plan for the project that will help assess whether the project is meeting the intended purpose and need and the goals and objectives. Chapter 6 displays the action plan and provides a prioritized list of actions with associated budget for the next five year period. Successive chapters contain appendices, references, definitions, and a glossary. The purpose of the project is

  14. Removal Action Plan for the Accelerated Retrieval Project for a Described Area within Pit 4

    SciTech Connect

    A. M. Tyson

    2006-08-01

    This Removal Action Plan documents the plan for implementation of the Comprehensive Environmental Response, Compenstion, and Liability Act non-time-critical removal action to be performed by the Accelerated Retrieval Project. The focus of the action is the limited excavation and retrieval of selected waste streams from a designated portion of the Radioactive Waste Management Complex Subsurface Disposal Area that are contaminated with volatile organic compounds, isotopes of uranium, or transuranic radionuclides. The selected retrieval area is approximately 0.2 ha (1/2 acre) and is located in the eastern portion of Pit 4. The proposed project is referred to as the Accelerated Retrieval Project. This Removal Action Plan details the major work elements, operations approach, and schedule, and summarizes the environmental, safety and health, and waste management considerations associated with the project.

  15. RECREATION Carrying Capacity Facts and Considerations. Report 1. Barkley Lock and Dam, Lake Barkley Project Area.

    DTIC Science & Technology

    1980-07-01

    Area Jul 1980 Acknowledgements We gratefully acknowledge the enthusiasm and excellent cooperation of the resource managers , rangers, and other Corps...recreation carrying capacity-related information for the Lake Barkley Project. The information is based upon: 1) user and management surveys conducted...WES was the Project Monitor. Dr. Adolph Anderson, WES, was Program Manager of the Environmental Laboratory (EL) Recreation Research Program. The

  16. Patterns and variability of projected bioclimatic habitat for Pinus albicaulis in the Greater Yellowstone Area.

    PubMed

    Chang, Tony; Hansen, Andrew J; Piekielek, Nathan

    2014-01-01

    Projected climate change at a regional level is expected to shift vegetation habitat distributions over the next century. For the sub-alpine species whitebark pine (Pinus albicaulis), warming temperatures may indirectly result in loss of suitable bioclimatic habitat, reducing its distribution within its historic range. This research focuses on understanding the patterns of spatiotemporal variability for future projected P.albicaulis suitable habitat in the Greater Yellowstone Area (GYA) through a bioclimatic envelope approach. Since intermodel variability from General Circulation Models (GCMs) lead to differing predictions regarding the magnitude and direction of modeled suitable habitat area, nine bias-corrected statistically down-scaled GCMs were utilized to understand the uncertainty associated with modeled projections. P.albicaulis was modeled using a Random Forests algorithm for the 1980-2010 climate period and showed strong presence/absence separations by summer maximum temperatures and springtime snowpack. Patterns of projected habitat change by the end of the century suggested a constant decrease in suitable climate area from the 2010 baseline for both Representative Concentration Pathways (RCPs) 8.5 and 4.5 climate forcing scenarios. Percent suitable climate area estimates ranged from 2-29% and 0.04-10% by 2099 for RCP 8.5 and 4.5 respectively. Habitat projections between GCMs displayed a decrease of variability over the 2010-2099 time period related to consistent warming above the 1910-2010 temperature normal after 2070 for all GCMs. A decreasing pattern of projected P.albicaulis suitable habitat area change was consistent across GCMs, despite strong differences in magnitude. Future ecological research in species distribution modeling should consider a full suite of GCM projections in the analysis to reduce extreme range contractions/expansions predictions. The results suggest that restoration strageties such as planting of seedlings and controlling

  17. Patterns and Variability of Projected Bioclimatic Habitat for Pinus albicaulis in the Greater Yellowstone Area

    PubMed Central

    Chang, Tony; Hansen, Andrew J.; Piekielek, Nathan

    2014-01-01

    Projected climate change at a regional level is expected to shift vegetation habitat distributions over the next century. For the sub-alpine species whitebark pine (Pinus albicaulis), warming temperatures may indirectly result in loss of suitable bioclimatic habitat, reducing its distribution within its historic range. This research focuses on understanding the patterns of spatiotemporal variability for future projected P.albicaulis suitable habitat in the Greater Yellowstone Area (GYA) through a bioclimatic envelope approach. Since intermodel variability from General Circulation Models (GCMs) lead to differing predictions regarding the magnitude and direction of modeled suitable habitat area, nine bias-corrected statistically down-scaled GCMs were utilized to understand the uncertainty associated with modeled projections. P.albicaulis was modeled using a Random Forests algorithm for the 1980–2010 climate period and showed strong presence/absence separations by summer maximum temperatures and springtime snowpack. Patterns of projected habitat change by the end of the century suggested a constant decrease in suitable climate area from the 2010 baseline for both Representative Concentration Pathways (RCPs) 8.5 and 4.5 climate forcing scenarios. Percent suitable climate area estimates ranged from 2–29% and 0.04–10% by 2099 for RCP 8.5 and 4.5 respectively. Habitat projections between GCMs displayed a decrease of variability over the 2010–2099 time period related to consistent warming above the 1910–2010 temperature normal after 2070 for all GCMs. A decreasing pattern of projected P.albicaulis suitable habitat area change was consistent across GCMs, despite strong differences in magnitude. Future ecological research in species distribution modeling should consider a full suite of GCM projections in the analysis to reduce extreme range contractions/expansions predictions. The results suggest that restoration strageties such as planting of seedlings and

  18. Freihoelser Forst Local Training Area Demonstration Project: Prescription development and installation

    SciTech Connect

    Hinchman, R.R.; Zellmer, S.D.; Severinghaus, W.D.; Brent, J.J.

    1989-04-01

    The Freiholser Forst Local Training Area (LTA) Rehabilitation Demonstration Project is part of the Integrated Training Area Management program being developed by the US Army Corps of Engineers` Construction Engineering Research Laboratory for the Seventh Army Training Command of the US Army in Europe. The rehabilitation demonstration project was begun in 1987 to develop and demonstrate rapid, cost-effective methods to stabilize the LTA`s barren, eroding maneuver areas and make training conditions more realistic. The sandy, infertile, and acidic soils at the LTA are considered the major factor limiting rehabilitation efforts there. The project involves the evaluation of three procedures to revegetate the soils, each incorporating identical methods for preparing the seedbed and a single seed mixture consisting of adapted, native species but using different soil amendments. All three treatments have satisfactorily reestablished vegetation and controlled erosion on the demonstration plots at the LTA, but their costs have varied widely.

  19. Freihoelser Forst Local Training Area Demonstration Project: Prescription development and installation

    SciTech Connect

    Hinchman, R.R.; Zellmer, S.D. . Energy Systems Div.); Severinghaus, W.D. ); Brent, J.J. )

    1989-04-01

    The Freiholser Forst Local Training Area (LTA) Rehabilitation Demonstration Project is part of the Integrated Training Area Management program being developed by the US Army Corps of Engineers' Construction Engineering Research Laboratory for the Seventh Army Training Command of the US Army in Europe. The rehabilitation demonstration project was begun in 1987 to develop and demonstrate rapid, cost-effective methods to stabilize the LTA's barren, eroding maneuver areas and make training conditions more realistic. The sandy, infertile, and acidic soils at the LTA are considered the major factor limiting rehabilitation efforts there. The project involves the evaluation of three procedures to revegetate the soils, each incorporating identical methods for preparing the seedbed and a single seed mixture consisting of adapted, native species but using different soil amendments. All three treatments have satisfactorily reestablished vegetation and controlled erosion on the demonstration plots at the LTA, but their costs have varied widely.

  20. St. Louis Area Earthquake Hazards Mapping Project - December 2008-June 2009 Progress Report

    USGS Publications Warehouse

    Williams, R.A.; Bauer, R.A.; Boyd, O.S.; Chung, J.; Cramer, C.H.; Gaunt, D.A.; Hempen, G.L.; Hoffman, D.; McCallister, N.S.; Prewett, J.L.; Rogers, J.D.; Steckel, P.J.; Watkins, C.M.

    2009-01-01

    This report summarizes the mission, the project background, the participants, and the progress of the St. Louis Area Earthquake Hazards Mapping Project (SLAEHMP) for the period from December 2008 through June 2009. During this period, the SLAEHMP held five conference calls and two face-to-face meetings in St. Louis, participated in several earthquake awareness public meetings, held one outreach field trip for the business and government community, collected and compiled new borehole and digital elevation data from partners, and published a project summary.

  1. Alaska Humans Factors Safety Study: The Northern Area

    NASA Technical Reports Server (NTRS)

    Connell, Linda; Reynard, William (Technical Monitor)

    1995-01-01

    At the request of the Alaska Air Carriers Association, researchers from the NASA Aviation Safety Reporting System, at NASA Ames Research Center, conducted a study on aspects of safety in Alaskan Part 135 air taxi operations. An interview form on human factors safety issues was created by a representative team from the FAA-Alaska, NTSB-Alaska, NASAASRS, and representatives of the Alaska Air Carriers Association which was subsequently used in the interviews of pilots and managers. Because of the climate and operational differences, the study was broken into two geographical areas, the southern coastal areas and the northern portion of the state. This presentation addresses the northern area, specifically: Bethel, Fairbanks, Nome, Kotzebue, and Barrow. The interview questions dealt with many of the potential pressures on pilots and managers associated with the daily air taxi operations in Alaska. The impact of the environmental factors such as the lack of available communication, navigation and weather information systems was evaluated. The results of this study will be used by government and industry working in Alaska. These findings will contribute important information on specific Alaska safety issues for eventual incorporation into training materials and policies that will help to assure the safe conduct of air taxi flights in Alaska.

  2. Alaska Humans Factors Safety Study: The Southern Coastal Area

    NASA Technical Reports Server (NTRS)

    Chappell, Sheryl L.; Reynard, William (Technical Monitor)

    1995-01-01

    At the request of the Alaska Air Carriers Association, researchers from the NASA Aviation Safety Reporting System, at NASA Ames Research Center, conducted a study on aspects of safety in Alaskan Part 135 air taxi operations. An interview form on human factors safety issues was created by a representative team from the FAA-Alaska, NTSB-Alaska, NASA-ASRS, and representatives of the Alaska Air Carriers Association which was subsequently used in the interviews of pilots and managers. Because of the climate and operational differences, the study was broken into two geographical areas, the southern coastal areas and the northern portion of the state. This presentation addresses the southern coastal areas, specifically: Anchorage, Dillingham, King Salmon, Kodiak, Cold Bay, Juneau, and Ketchikan. The interview questions dealt with many of the potential pressures on pilots and managers associated with the daily air taxi operations in Alaska. The impact of the environmental factors such as the lack of available communication, navigation and weather information systems was evaluated. The results of this study will be used by government and industry working in Alaska. These findings will contribute important information on specific Alaska safety issues for eventual incorporation into training materials and policies that will help to assure the safe conduct of air taxi flights in Alaska.

  3. Human migration, protected areas, and conservation outreach in Tanzania.

    PubMed

    Salerno, Jonathan D; Borgerhoff Mulder, Monique; Kefauver, Shawn C

    2014-06-01

    A recent discussion debates the extent of human in-migration around protected areas (PAs) in the tropics. One proposed argument is that rural migrants move to bordering areas to access conservation outreach benefits. A counter proposal maintains that PAs have largely negative effects on local populations and that outreach initiatives even if successful present insufficient benefits to drive in-migration. Using data from Tanzania, we examined merits of statistical tests and spatial methods used previously to evaluate migration near PAs and applied hierarchical modeling with appropriate controls for demographic and geographic factors to advance the debate. Areas bordering national parks in Tanzania did not have elevated rates of in-migration. Low baseline population density and high vegetation productivity with low interannual variation rather than conservation outreach explained observed migration patterns. More generally we argue that to produce results of conservation policy significance, analyses must be conducted at appropriate scales, and we caution against use of demographic data without appropriate controls when drawing conclusions about migration dynamics.

  4. Selectivity to Translational Egomotion in Human Brain Motion Areas

    PubMed Central

    Pitzalis, Sabrina; Sdoia, Stefano; Bultrini, Alessandro; Committeri, Giorgia; Di Russo, Francesco; Fattori, Patrizia; Galletti, Claudio; Galati, Gaspare

    2013-01-01

    The optic flow generated when a person moves through the environment can be locally decomposed into several basic components, including radial, circular, translational and spiral motion. Since their analysis plays an important part in the visual perception and control of locomotion and posture it is likely that some brain regions in the primate dorsal visual pathway are specialized to distinguish among them. The aim of this study is to explore the sensitivity to different types of egomotion-compatible visual stimulations in the human motion-sensitive regions of the brain. Event-related fMRI experiments, 3D motion and wide-field stimulation, functional localizers and brain mapping methods were used to study the sensitivity of six distinct motion areas (V6, MT, MST+, V3A, CSv and an Intra-Parietal Sulcus motion [IPSmot] region) to different types of optic flow stimuli. Results show that only areas V6, MST+ and IPSmot are specialized in distinguishing among the various types of flow patterns, with a high response for the translational flow which was maximum in V6 and IPSmot and less marked in MST+. Given that during egomotion the translational optic flow conveys differential information about the near and far external objects, areas V6 and IPSmot likely process visual egomotion signals to extract information about the relative distance of objects with respect to the observer. Since area V6 is also involved in distinguishing object-motion from self-motion, it could provide information about location in space of moving and static objects during self-motion, particularly in a dynamically unstable environment. PMID:23577096

  5. Human vocal attractiveness as signaled by body size projection.

    PubMed

    Xu, Yi; Lee, Albert; Wu, Wing-Li; Liu, Xuan; Birkholz, Peter

    2013-01-01

    Voice, as a secondary sexual characteristic, is known to affect the perceived attractiveness of human individuals. But the underlying mechanism of vocal attractiveness has remained unclear. Here, we presented human listeners with acoustically altered natural sentences and fully synthetic sentences with systematically manipulated pitch, formants and voice quality based on a principle of body size projection reported for animal calls and emotional human vocal expressions. The results show that male listeners preferred a female voice that signals a small body size, with relatively high pitch, wide formant dispersion and breathy voice, while female listeners preferred a male voice that signals a large body size with low pitch and narrow formant dispersion. Interestingly, however, male vocal attractiveness was also enhanced by breathiness, which presumably softened the aggressiveness associated with a large body size. These results, together with the additional finding that the same vocal dimensions also affect emotion judgment, indicate that humans still employ a vocal interaction strategy used in animal calls despite the development of complex language.

  6. Columbia Basin Wildlife Mitigation Project : Rainwater Wildlife Area Final Management Plan.

    SciTech Connect

    Childs, Allen

    2002-03-01

    This Draft Management Plan has been developed by the Confederated Tribes of the Umatilla Indian Reservation (CTUIR) to document how the Rainwater Wildlife Area (formerly known as the Rainwater Ranch) will be managed. The plan has been developed under a standardized planning process developed by the Bonneville Power Administration (BPA) for Columbia River Basin Wildlife Mitigation Projects (See Appendix A and Guiding Policies Section below). The plan outlines the framework for managing the project area, provides an assessment of existing conditions and key resource issues, and presents an array of habitat management and enhancement strategies. The plan culminates into a 5-Year Action Plan that will focus our management actions and prioritize funding during the Fiscal 2001-2005 planning period. This plan is a product of nearly two years of field studies and research, public scoping, and coordination with the Rainwater Advisory Committee. The committee consists of representatives from tribal government, state agencies, local government, public organizations, and members of the public. The plan is organized into several sections with Chapter 1 providing introductory information such as project location, purpose and need, project goals and objectives, common elements and assumptions, coordination efforts and public scoping, and historical information about the project area. Key issues are presented in Chapter 2 and Chapter 3 discusses existing resource conditions within the wildlife area. Chapter 4 provides a detailed presentation on management activities and Chapter 5 outlines a monitoring and evaluation plan for the project that will help assess whether the project is meeting the intended purpose and need and the goals and objectives. Chapter 6 displays the action plan and provides a prioritized list of actions with associated budget for the next five year period. Successive chapters contain appendices, references, definitions, and a glossary.

  7. Detection of human taeniases in Tibetan endemic areas, China.

    PubMed

    Li, Tiaoying; Chen, Xingwang; Yanagida, Tetsuya; Wang, Hao; Long, Changping; Sako, Yasuhito; Okamoto, Munehir; Wu, Yunfei; Giraudoux, Patrick; Raoul, Francis; Nkouawa, Agathe; Nakao, Minoru; Craig, Philip S; Ito, Akira

    2013-11-01

    Detection of taeniasis carriers of Taenia solium is essential for control of cysticercosis in humans and pigs. In the current study, we assessed the positive detection rate of a self-detection tool, stool microscopy with direct smear and coproPCR for taeniasis carriers in endemic Tibetan areas of northwest Sichuan. The self-detection tool through questioning about a history of proglottid expulsion within the previous one year showed an overall positive detection rate of more than 80% for Taenia saginata, T. solium and T. asiatica. The positive detection rate was similar for T. saginata and T. solium. In 132 taeniid tapeworm carriers, 68 (51·5%) were detected by microscopy and 92 (69·7%) were diagnosed by coproPCR. A combination of microscopy and coproPCR increased the positive detection rate to 77·3%. There remained 10 cases (7·6%) coproPCR negative but microscopy positive. Due to the high cost and complicated process, coproPCR is required for the identification of Taenia species only when necessary, though it had a significant higher positive detection rate than microscopy. Combined use of self-detection and stool microscopy are recommended in community-based mass screening for taeniases in this Tibetan area or in other situation-similar endemic regions.

  8. Content Area Bilingual Education: Project CABE 1988-89. OREA Report.

    ERIC Educational Resources Information Center

    Berney, Tomi D.; Lista, Carlos A.

    Project CABE (Content Area Bilingual Education) offered instruction in English as a Second Language (ESL) and Native Language Arts (NLA) to 823 limited English proficient Spanish-Speaking students in grades 1 through 9 in 34 schools in Manhattan, Brooklyn, and Queens (New York). All students were two or more years below level in mathematics and…

  9. Using the Gravity Model to Delineate a Trade Area: A Class Project.

    ERIC Educational Resources Information Center

    Dzik, Anthony J.

    1992-01-01

    Reports that students who might be bored or intimidated by economic geographic theory become enthusiastic when they can apply it to their own experiences. Describes a class project involving fieldwork and in-class analysis on delineating the retail trade area of a small Ohio city. Includes three maps and mathematical formulae for data analysis.…

  10. P.C.A.P. Project Profiles. Queensland Priority Country Area Program--Evaluation Series.

    ERIC Educational Resources Information Center

    Fowler, C. F.; Peters, J. E.

    Thirty-two projects designed to improve educational opportunities of rural Queensland children were funded as part of the Disadvantaged Schools Program in 1979 and 1980. This program resulted from a 1977-79 Schools Commission report which suggested that students in country areas may be disadvantaged compared to urban dwellers, with respect to…

  11. EPA Awards New Great Lakes Restoration Funding for Projects in the Clinton River Area of Concern

    EPA Pesticide Factsheets

    No. 15-OPA166 HARRISON TOWNSHIP, MICH. (Nov. 9, 2015) -- The U.S Environmental Protection Agency today announced the award of new funding for major Great Lakes Restoration Initiative projects in the Clinton River Area of Concern totaling nearly $20 m

  12. Evaluation of the USDA Northeast Area-wide Tick Control Project by Meta-analysis

    Technology Transfer Automated Retrieval System (TEKTRAN)

    As part of the Northeast Area-wide Tick Control Project (NEATCP), meta-analyses were performed using pooled data on the extent of tick-vector control achieved through seven concurrent studies, conducted within five states, using USDA ‘4-Poster’ devices to deliver targeted-acaricide to white-tailed d...

  13. D-Area Drip Irrigation/Phytoremediation Project: SRTC Report on Phase 1

    SciTech Connect

    Wilde, E.W.

    2001-09-11

    The overall objective of this project is to evaluate a novel drip irrigation-phytoremediation process for remediating volatile organic contaminants (VOCs), primarily trichloroethylene (TCE), from groundwater in D-Area at the Savannah River Site (SRS). The process is expected to be less expensive and more beneficial to the environment than alternative TCE remediation technologies.

  14. An Ecological Characterization and Landscape Assessment of the Muddy-Virgin River Project Area

    EPA Science Inventory

    The Muddy-Virgin River Project Area covers a large part of southern Nevada. Very little is known about the water quality of the entire Basin. The Muddy and Virgin Rivers drain into Lake Mead which provides drinking water for communities located in the Las Vegas Valley. The are...

  15. 76 FR 65493 - Draft Environmental Assessment; Giant Miscanthus in REPREVE Renewables, LLC Project Areas Under...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-21

    ... REPREVE Renewables, LLC Project Areas Under the Biomass Crop Assistance Program AGENCY: Commodity Credit... miscanthus (Miscanthus X giganteus) as a dedicated energy crop to be grown in the REPREVE Renewables, LLC... Biomass Crop Assistance Program (BCAP). This notice provides a means for the public to voice any...

  16. Delinquency Prevention in South Chicago. A Fifty-Year Assessment of the Chicago Area Project.

    ERIC Educational Resources Information Center

    Schlossman, Steven; And Others

    This report examines the Chicago Area Project (CAP), the first community-based delinquency prevention program, from both a historical and a contemporary perspective. The analysis is in three parts. The first part describes CAP's founding in the 1930s and analyzes the process through which it was established and the operation of its prevention…

  17. METHODOLOGY FOR PROJECTION OF OCCUPATIONAL TRENDS IN THE DENVER STANDARD METROPOLITAN STATISTICAL AREA.

    ERIC Educational Resources Information Center

    FISHMAN, LESLIE; AND OTHERS

    VARIOUS METHODS AVAILABLE FOR A PROJECTION OF OCCUPATIONAL REQUIREMENTS OF A STANDARD METROPOLITAN STATISTICAL AREA (SMSA) ARE REVIEWED, AS WELL AS THE DATA AVAILABLE TO IMPLEMENT THESE APPROACHES. TWO "NAIVE" MODELS ARE RECOMMENDED FOR USE AS BENCH MARKS AGAINST WHICH TO COMPARE MORE SOPHISTICATED APPROACHES--THE "NO CHANGE"…

  18. Business Marketing Information Systems Skills. Voc-Ed Project. Business Data Processing Career Area. Report.

    ERIC Educational Resources Information Center

    Milwaukee Area Technical Coll., WI.

    This report and research analysis relate to the Milwaukee Area Technical College Research Project, a study undertaken to determine a curriculum to meet the information processing/management training needs of individuals entering or continuing careers in the information marketing and business data processing occupational clusters. The report of…

  19. Underground test area quality assurance project plan, Nevada test site, Nevada. Revision 1

    SciTech Connect

    1997-04-01

    This Quality Assurance Project Plan (QAPP) is one of the planning documents used for the Underground Test Area (UGTA) Subproject at the Nevada Test Site (NTS) which falls under the oversight of the U.S. Department of Energy, Nevada Operations Office (DOE/NV) Nevada Environmental Restoration Project (NV ERP). The Nevada ERP consists of environmental restoration activities on the NTS, Tonopah Test Range, Nellis Air Force Range, and eight sites in five other states. The UGTA Subproject constitutes a component of the Nevada Environmental Restoration Project. The purposes of the UGTA Subproject are to define boundaries around each Corrective Action Unit (CAU), as defined by the Federal Facility Agreement and Consent Order (FFACO), that establish areas containing water that may be unsafe for domestic or municipal use and to establish monitoring programs for each CAU that will verify modeling upon which the boundaries are based.

  20. EPA Critical Path Science Plan Projects 19, 20 and 21: Human and Bovine Source Detection

    EPA Science Inventory

    The U.S. EPA Critical Path Science Plan Projects are: Project 19: develop novel bovine and human host-specific PCR assays and complete performance evaluation with other published methods. Project 20: Evaluate human-specific assays with water samples impacted with different lev...

  1. Adding dynamics to the Human Connectome Project with MEG

    PubMed Central

    Larson-Prior, L. J.; Oostenveld, R.; Della Penna, S.; Michalareas, G.; Prior, F.; Babajani-Feremi, A.; Schoffelen, J-M.; Marzetti, L.; de Pasquale, F.; Di Pompeo, F.; Stout, J.; Woolrich, M.; Luo, Q.; Bucholz, R.; Fries, P.; Pizzella, V.; Romani, G.L.; Corbetta, M.; Snyder, A. Z.

    2013-01-01

    The Human Connectome Project (HCP) seeks to map the structural and functional connections between network elements in the human brain. Magnetoencephalography (MEG) provides a temporally rich source of information on brain network dynamics and represents one source of functional connectivity data to be provided by the HCP. High quality MEG data will be collected from 50 twin pairs both in the resting state and during performance of motor, working memory and language tasks. These data will be available to the general community. Additionally, using the cortical parcellation scheme common to all imaging modalities, the HCP will provide processing pipelines for calculating connection matrices as a function of time and frequency. Together with structural and functional data generated using magnetic resonance imaging methods, these data represent a unique opportunity to investigate brain network connectivity in a large cohort of normal adult human subjects. The analysis pipeline software and the dynamic connectivity matrices that it generates will all be made freely available to the research community. PMID:23702419

  2. Evolution of mammalian sensorimotor cortex: thalamic projections to parietal cortical areas in Monodelphis domestica.

    PubMed

    Dooley, James C; Franca, João G; Seelke, Adele M H; Cooke, Dylan F; Krubitzer, Leah A

    2014-01-01

    The current experiments build upon previous studies designed to reveal the network of parietal cortical areas present in the common mammalian ancestor. Understanding this ancestral network is essential for highlighting the basic somatosensory circuitry present in all mammals, and how this basic plan was modified to generate species specific behaviors. Our animal model, the short-tailed opossum (Monodelphis domestica), is a South American marsupial that has been proposed to have a similar ecological niche and morphology to the earliest common mammalian ancestor. In this investigation, we injected retrograde neuroanatomical tracers into the face and body representations of primary somatosensory cortex (S1), the rostral and caudal somatosensory fields (SR and SC), as well as a multimodal region (MM). Projections from different architectonically defined thalamic nuclei were then quantified. Our results provide further evidence to support the hypothesized basic mammalian plan of thalamic projections to S1, with the lateral and medial ventral posterior thalamic nuclei (VPl and VPm) projecting to S1 body and S1 face, respectively. Additional strong projections are from the medial division of posterior nucleus (Pom). SR receives projections from several midline nuclei, including the medial dorsal, ventral medial nucleus, and Pom. SC and MM show similar patterns of connectivity, with projections from the ventral anterior and ventral lateral nuclei, VPm and VPl, and the entire posterior nucleus (medial and lateral). Notably, MM is distinguished from SC by relatively dense projections from the dorsal division of the lateral geniculate nucleus and pulvinar. We discuss the finding that S1 of the short-tailed opossum has a similar pattern of projections as other marsupials and mammals, but also some distinct projections not present in other mammals. Further we provide additional support for a primitive posterior parietal cortex which receives input from multiple modalities.

  3. Evolution of mammalian sensorimotor cortex: thalamic projections to parietal cortical areas in Monodelphis domestica

    PubMed Central

    Dooley, James C.; Franca, João G.; Seelke, Adele M. H.; Cooke, Dylan F.; Krubitzer, Leah A.

    2015-01-01

    The current experiments build upon previous studies designed to reveal the network of parietal cortical areas present in the common mammalian ancestor. Understanding this ancestral network is essential for highlighting the basic somatosensory circuitry present in all mammals, and how this basic plan was modified to generate species specific behaviors. Our animal model, the short-tailed opossum (Monodelphis domestica), is a South American marsupial that has been proposed to have a similar ecological niche and morphology to the earliest common mammalian ancestor. In this investigation, we injected retrograde neuroanatomical tracers into the face and body representations of primary somatosensory cortex (S1), the rostral and caudal somatosensory fields (SR and SC), as well as a multimodal region (MM). Projections from different architectonically defined thalamic nuclei were then quantified. Our results provide further evidence to support the hypothesized basic mammalian plan of thalamic projections to S1, with the lateral and medial ventral posterior thalamic nuclei (VPl and VPm) projecting to S1 body and S1 face, respectively. Additional strong projections are from the medial division of posterior nucleus (Pom). SR receives projections from several midline nuclei, including the medial dorsal, ventral medial nucleus, and Pom. SC and MM show similar patterns of connectivity, with projections from the ventral anterior and ventral lateral nuclei, VPm and VPl, and the entire posterior nucleus (medial and lateral). Notably, MM is distinguished from SC by relatively dense projections from the dorsal division of the lateral geniculate nucleus and pulvinar. We discuss the finding that S1 of the short-tailed opossum has a similar pattern of projections as other marsupials and mammals, but also some distinct projections not present in other mammals. Further we provide additional support for a primitive posterior parietal cortex which receives input from multiple modalities. PMID

  4. The 300 Area Integrated Field Research Challenge Quality Assurance Project Plan

    SciTech Connect

    Fix, N. J.

    2009-04-29

    Pacific Northwest National Laboratory and a group of expert collaborators are using the U.S. Department of Energy Hanford Site 300 Area uranium plume within the footprint of the 300-FF-5 groundwater operable unit as a site for an Integrated Field-Scale Subsurface Research Challenge (IFRC). The IFRC is entitled Multi-Scale Mass Transfer Processes Controlling Natural Attenuation and Engineered Remediation: An IFRC Focused on the Hanford Site 300 Area Uranium Plume Project. The theme is investigation of multi-scale mass transfer processes. A series of forefront science questions on mass transfer are posed for research that relate to the effect of spatial heterogeneities; the importance of scale; coupled interactions between biogeochemical, hydrologic, and mass transfer processes; and measurements/approaches needed to characterize and model a mass transfer-dominated system. This Quality Assurance Project Plan provides the quality assurance requirements and processes that will be followed by the 300 Area IFRC Project. This plan is designed to be used exclusively by project staff.

  5. Assessment of Flooded Areas Projections and Floods Potential Impacts Applying Remote Sensing Imagery and Demographic Data

    NASA Astrophysics Data System (ADS)

    Rodriguez, D. A.; Carriello, F.; Fernandes, P. J. F.; Garofolo Lopes, L.; Siqueira Júnior, J. L.

    2016-06-01

    Assessing vulnerability and potential impacts associated with extreme discharges requires an accurate topographic description in order to estimate the extension of flooded areas. However, in most populated regions, topographic data obtained by in-situ measurements is not available. In this case, digital elevation models derived from remote sensing date are usually applied. Moreover, this digital elevation models have intrinsic errors that introduce bigger uncertainty in results than the associated to hydrological projections. On the other hand, estimations of flooded areas through remote sensing images provide accurate information, which could be used for the construction of river level-flooded area relationships regarding vulnerability assessment. In this work, this approach is applied for the city of Porto Velho in the Brazilian Amazonia to assess potential vulnerability to floods associated with climate change projections. The approach is validated using census data, provided by the Brazilian Institute of Geography and Statistics, and information about socio-economical injuries associated to historical floods, provided by the Brazilian Civil Defence. Hydrological projections under climate change are carried out using several downscaling of climate projections as inputs in a hydrological model. Results show more accurate estimation of flood impacts than the obtained using digital elevation models derivate from remote sensing data. This reduces uncertainties in the assessment of vulnerability to floods associated with climate change in the region.

  6. 76 FR 16609 - Proposed Information Collection; Comment Request; Identification of Human Cell Lines Project

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-24

    ...; Identification of Human Cell Lines Project AGENCY: National Institute of Standards and Technology (NIST...) profiling up to 1500 human cell line samples as part of the Identification of Human Cell Lines Project. All... for Biotechnology Information (NCBI) and will be used to differentiate among cell lines, as...

  7. Evaluation of dredged material proposed for ocean disposal from Eastchester Project Area, New York

    SciTech Connect

    Antrim, L.D.; Pinza, M.R.; Barrows, E.S.; Gardiner, W.W.; Tokos, J.J.S.; Gruendell, B.D.; Word, J.Q.

    1996-07-01

    The objective of the Eastchester project (Federal Project [FP] No. 6) was to evaluate proposed dredged material from the Eastchester project area in the Hutchinson River to determine its suitability for unconfined ocean disposal at the Mud Dump Site. Eastchester was one of seven waterways that the U. S. Army Corps of Engineers-New York District (USACE-NYD) requested the Battelle/Marine Sciences Laboratory (MSL) to sample and evaluate for dredging and disposal in March 1994. The evaluation of proposed dredged material from the Eastchester project area consisted of bulk sediment chemical analyses, chemical analyses of dredging site water and elutriate, water- column and benthic acute toxicity tests, and bioaccumulation studies. Eighteen individual sediment core samples collected from the Eastchester project area were analyzed for grain size, moisture content, and total organic carbon (TOC). Two composite sediment samples, representing the upstream and lower reaches of the area proposed for dredging, were analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAHs), and 1,4- dichlorobenzene. Dredging site water and elutriate water, which is prepared from the suspended-particulate phase (SPP) of the two Eastchester sediment composites, were analyzed for metals, pesticides, and PCBS. An additional 1 1 composite samples were created for the USACE-New England Division (USACE-NED) using the same 18 Eastchester core samples but combined into different composites. These composites were analyzed for metals, chlorinated pesticides, PCB congeners, PAHS, and 1,4-dichlorobenzene. Water-column or SPP toxicity tests were performed along with bioaccumulation tests.

  8. Human Genome Teacher Networking Project, Final Report, April 1, 1992 - March 31, 1998

    SciTech Connect

    Collins, Debra

    1999-10-01

    Project to provide education regarding ethical legal and social implications of Human Genome Project to high school science teachers through two consecutive summer workshops, in class activities, and peer teaching workshops.

  9. Asymmetric projections of the arcuate fasciculus to the temporal cortex underlie lateralized language function in the human brain

    PubMed Central

    Takaya, Shigetoshi; Kuperberg, Gina R.; Liu, Hesheng; Greve, Douglas N.; Makris, Nikos; Stufflebeam, Steven M.

    2015-01-01

    The arcuate fasciculus (AF) in the human brain has asymmetric structural properties. However, the topographic organization of the asymmetric AF projections to the cortex and its relevance to cortical function remain unclear. Here we mapped the posterior projections of the human AF in the inferior parietal and lateral temporal cortices using surface-based structural connectivity analysis based on diffusion MRI and investigated their hemispheric differences. We then performed the cross-modal comparison with functional connectivity based on resting-state functional MRI (fMRI) and task-related cortical activation based on fMRI using a semantic classification task of single words. Structural connectivity analysis showed that the left AF connecting to Broca's area predominantly projected in the lateral temporal cortex extending from the posterior superior temporal gyrus to the mid part of the superior temporal sulcus and the middle temporal gyrus, whereas the right AF connecting to the right homolog of Broca's area predominantly projected to the inferior parietal cortex extending from the mid part of the supramarginal gyrus to the anterior part of the angular gyrus. The left-lateralized projection regions of the AF in the left temporal cortex had asymmetric functional connectivity with Broca's area, indicating structure-function concordance through the AF. During the language task, left-lateralized cortical activation was observed. Among them, the brain responses in the temporal cortex and Broca's area that were connected through the left-lateralized AF pathway were specifically correlated across subjects. These results suggest that the human left AF, which structurally and functionally connects the mid temporal cortex and Broca's area in asymmetrical fashion, coordinates the cortical activity in these remote cortices during a semantic decision task. The unique feature of the left AF is discussed in the context of the human capacity for language. PMID:26441551

  10. Asymmetric projections of the arcuate fasciculus to the temporal cortex underlie lateralized language function in the human brain.

    PubMed

    Takaya, Shigetoshi; Kuperberg, Gina R; Liu, Hesheng; Greve, Douglas N; Makris, Nikos; Stufflebeam, Steven M

    2015-01-01

    The arcuate fasciculus (AF) in the human brain has asymmetric structural properties. However, the topographic organization of the asymmetric AF projections to the cortex and its relevance to cortical function remain unclear. Here we mapped the posterior projections of the human AF in the inferior parietal and lateral temporal cortices using surface-based structural connectivity analysis based on diffusion MRI and investigated their hemispheric differences. We then performed the cross-modal comparison with functional connectivity based on resting-state functional MRI (fMRI) and task-related cortical activation based on fMRI using a semantic classification task of single words. Structural connectivity analysis showed that the left AF connecting to Broca's area predominantly projected in the lateral temporal cortex extending from the posterior superior temporal gyrus to the mid part of the superior temporal sulcus and the middle temporal gyrus, whereas the right AF connecting to the right homolog of Broca's area predominantly projected to the inferior parietal cortex extending from the mid part of the supramarginal gyrus to the anterior part of the angular gyrus. The left-lateralized projection regions of the AF in the left temporal cortex had asymmetric functional connectivity with Broca's area, indicating structure-function concordance through the AF. During the language task, left-lateralized cortical activation was observed. Among them, the brain responses in the temporal cortex and Broca's area that were connected through the left-lateralized AF pathway were specifically correlated across subjects. These results suggest that the human left AF, which structurally and functionally connects the mid temporal cortex and Broca's area in asymmetrical fashion, coordinates the cortical activity in these remote cortices during a semantic decision task. The unique feature of the left AF is discussed in the context of the human capacity for language.

  11. Asymmetric projections of the arcuate fasciculus to the temporal cortex underlie lateralized language function in the human brain

    DOE PAGES

    Takaya, Shigetoshi; Kuperberg, Gina R.; Liu, Hesheng; ...

    2015-09-15

    The arcuate fasciculus (AF) in the human brain has asymmetric structural properties. However, the topographic organization of the asymmetric AF projections to the cortex and its relevance to cortical function remain unclear. Here we mapped the posterior projections of the human AF in the inferior parietal and lateral temporal cortices using surface-based structural connectivity analysis based on diffusion MRI and investigated their hemispheric differences. We then performed the cross-modal comparison with functional connectivity based on resting-state functional MRI (fMRI) and task-related cortical activation based on fMRI using a semantic classification task of single words. Structural connectivity analysis showed that themore » left AF connecting to Broca's area predominantly projected in the lateral temporal cortex extending from the posterior superior temporal gyrus to the mid part of the superior temporal sulcus and the middle temporal gyrus, whereas the right AF connecting to the right homolog of Broca's area predominantly projected to the inferior parietal cortex extending from the mid part of the supramarginal gyrus to the anterior part of the angular gyrus. The left-lateralized projection regions of the AF in the left temporal cortex had asymmetric functional connectivity with Broca's area, indicating structure-function concordance through the AF. During the language task, left-lateralized cortical activation was observed. Among them, the brain responses in the temporal cortex and Broca's area that were connected through the left-lateralized AF pathway were specifically correlated across subjects. These results suggest that the human left AF, which structurally and functionally connects the mid temporal cortex and Broca's area in asymmetrical fashion, coordinates the cortical activity in these remote cortices during a semantic decision task. As a result, the unique feature of the left AF is discussed in the context of the human capacity for language.« less

  12. Asymmetric projections of the arcuate fasciculus to the temporal cortex underlie lateralized language function in the human brain

    SciTech Connect

    Takaya, Shigetoshi; Kuperberg, Gina R.; Liu, Hesheng; Greve, Douglas N.; Makris, Nikos; Stufflebeam, Steven M.

    2015-09-15

    The arcuate fasciculus (AF) in the human brain has asymmetric structural properties. However, the topographic organization of the asymmetric AF projections to the cortex and its relevance to cortical function remain unclear. Here we mapped the posterior projections of the human AF in the inferior parietal and lateral temporal cortices using surface-based structural connectivity analysis based on diffusion MRI and investigated their hemispheric differences. We then performed the cross-modal comparison with functional connectivity based on resting-state functional MRI (fMRI) and task-related cortical activation based on fMRI using a semantic classification task of single words. Structural connectivity analysis showed that the left AF connecting to Broca's area predominantly projected in the lateral temporal cortex extending from the posterior superior temporal gyrus to the mid part of the superior temporal sulcus and the middle temporal gyrus, whereas the right AF connecting to the right homolog of Broca's area predominantly projected to the inferior parietal cortex extending from the mid part of the supramarginal gyrus to the anterior part of the angular gyrus. The left-lateralized projection regions of the AF in the left temporal cortex had asymmetric functional connectivity with Broca's area, indicating structure-function concordance through the AF. During the language task, left-lateralized cortical activation was observed. Among them, the brain responses in the temporal cortex and Broca's area that were connected through the left-lateralized AF pathway were specifically correlated across subjects. These results suggest that the human left AF, which structurally and functionally connects the mid temporal cortex and Broca's area in asymmetrical fashion, coordinates the cortical activity in these remote cortices during a semantic decision task. As a result, the unique feature of the left AF is discussed in the context of the human capacity for language.

  13. Fluoride analysis of human milk in remote areas of Thailand.

    PubMed

    Chuckpaiwong, S; Nakornchai, S; Surarit, R; Soo-ampon, S

    2000-09-01

    The objective of this study was to measure the fluoride content in human milk collected from mothers living in remote areas of Thailand and to correlate it with fluoride concentrations in drinking water and water for domestic use. Four to five ml of breast milk were sampled from mothers living in villages where schools under the jurisdiction of the Department of Border Patrol Police were located. The schools were sampled by Multiple Stratified Cluster Random Sampling. Fluoride was determined by microdiffusion method. Statistical analysis were made by ANOVA and LSD test. Correlation between fluoride content in milk and water was assessed by Kendall's tau-b. The mean fluoride concentration in breast milk was 0.017+/-0.02 ppm. There was no difference in breast milk fluoride concentration between regions (p=0.6). No correlation was found between breast milk fluoride content and fluoride concentrations in either drinking water or water for domestic use (r(tau) = -0.09, p = 0.32, r(tau) = -0.04, p = 0.65 respectively).

  14. Human pluripotent stem cell differentiation into authentic striatal projection neurons.

    PubMed

    Delli Carri, Alessia; Onorati, Marco; Castiglioni, Valentina; Faedo, Andrea; Camnasio, Stefano; Toselli, Mauro; Biella, Gerardo; Cattaneo, Elena

    2013-08-01

    Here we present the principles and steps of a protocol that we have recently developed for the differentiation of hES/iPS cells into the authentic human striatal projection medium spiny neurons (MSNs) that die in Huntington's Disease (HD). Authenticity is judged by the convergence of multiple features within individual cells. Our procedure lasts 80 days and couples neural induction via BMP/TGF-β inhibition with exposure to the developmental factors sonic hedgehog (SHH) and dickkopf1 (DKK-1) to drive ventral telencephalic specification, followed by terminal differentiation [1]. Authenticity of the resulting neuronal population is monitored by the appearance of FOXG1(+)/GSX2(+) progenitor cells of the lateral ganglionic eminence (LGE) at day 15-25 of differentiation, followed by appearance of CTIP2-, FOXP1- and FOXP2-positive cells at day 45. These precursor cells then mature into MAP2(+)/GABA(+) neurons with 20 % of them ultimately co-expressing the DARPP-32 and CTIP2 diagnostic markers and carrying electrophysiological properties expected for fully functional MSNs.The protocol is characterized by its replicability in at least three human pluripotent cell lines. Altogether this protocol defines a useful platform for in vitro developmental neurobiology studies, drug screening, and regenerative medicine approaches.

  15. THE HETEROGENEITY OF VENTRAL TEGMENTAL AREA NEURONS: PROJECTION FUNCTIONS IN A MOOD-RELATED CONTEXT

    PubMed Central

    Walsh, J.J.; Han, M.H.

    2015-01-01

    The ventral tegmental area (VTA) in the brain’s reward circuitry is composed of a heterogeneous population of dopamine, GABA, and glutamate neurons that play important roles in mediating mood-related functions including depression. These neurons project to different brain regions, including the nucleus accumbens (NAc), the medial prefrontal cortex (mPFC), and the amygdala. The functional understanding of these projection pathways has been improved since the extensive use of advanced techniques such as viral-mediated gene transfer, cell-type specific neurophysiology and circuit-probing optogenetics. In this article, we will discuss the recent progress in understanding these VTA projection-specific functions, focusing on mood-related disorders. PMID:24931766

  16. Digital-model study of ground-water hydrology, Columbia Basin Irrigation Project Area, Washington

    USGS Publications Warehouse

    Tanaka, H.H.; Hansen, A.J.; Skrivan, J.A.

    1974-01-01

    Since 1952 water diverted from the Columbia River at Grand Coulee Dam has been used to irrigate parts of the Columbia Basin Irrigation Project area in eastern Washington, and as a result ground-water levels generally have risen in the area. The rapid increases in ground-water inflow, outflow, and storage from irrigation have created a need for a better understanding of the ground-water system before and after the start of irrigation to establish guidelines necessary for management of the area's ground-water resource. Data and information from previous geologic and hydrologic studies were used as a basis for quantitative analyses of ground-water inflow and outflow by means of digital computer models representing three major areas--Quincy Basin, Pasco Basin, and Royal Slope.

  17. Evaluation of dredged material proposed for ocean disposal from Hackensack River Project Area, New York

    SciTech Connect

    Gruendell, B.D.; Barrows, E.S.; Borde, A.B.

    1997-01-01

    The objective of the bioassay reevaluation of the Hackensack River Federal Project was to reperform toxicity testing on proposed dredged material with current ammonia reduction protocols. Hackensack River was one of four waterways sampled and evaluated for dredging and disposal in April 1993. Sediment samples were re-collected from the Hackensack River Project area in August 1995. Tests and analyses were conducted according to the manual developed by the USACE and the U.S. Environmental Protection Agency (EPA), Evaluation of Dredged Material Proposed for Ocean Disposal (Testing Manual), commonly referred to as the {open_quotes}Green Book,{close_quotes} and the regional manual developed by the USACE-NYD and EPA Region II, Guidance for Performing Tests on Dredged Material to be Disposed of in Ocean Waters. The reevaluation of proposed dredged material from the Hackensack River project area consisted of benthic acute toxicity tests. Thirty-three individual sediment core samples were collected from the Hackensack River project area. Three composite sediments, representing each reach of the area proposed for dredging, were used in benthic acute toxicity testing. Benthic acute toxicity tests were performed with the amphipod Ampelisca abdita and the mysid Mysidopsis bahia. The amphipod and mysid benthic toxicity test procedures followed EPA guidance for reduction of total ammonia concentrations in test systems prior to test initiation. Statistically significant acute toxicity was found in all three Hackensack River composites in the static renewal tests with A. abdita, but not in the static tests with M. bahia. Statistically significant acute toxicity and a greater than 20% increase in mortality over the reference sediment was found in the static renewal tests with A. abdita. Statistically significant mortality 10% over reference sediment was observed in the M. bahia static tests. 5 refs., 2 figs., 2 tabs.

  18. Evaluation of dredged material proposed for ocean disposal from Arthur Kill Project Area, New York

    SciTech Connect

    Gruendell, B.D.; Barrows, E.S.; Borde, A.B.

    1997-01-01

    The objective of the bioassay reevaluation of Arthur Kill Federal Project was to reperform toxicity testing on proposed dredged material following current ammonia reduction protocols. Arthur Kill was one of four waterways sampled and evaluated for dredging and disposal in April 1993. Sediment samples were recollected from the Arthur Kill Project areas in August 1995. Tests and analyses were conducted according to the manual developed by the USACE and the U.S. Environmental Protection Agency (EPA), Evaluation of Dredged Material Proposed for Ocean Disposal (Testing Manual), commonly referred to as the {open_quotes}Green Book,{close_quotes} and the regional manual developed by the USACE-NYD and EPA Region II, Guidance for Performing Tests on Dredged Material to be Disposed of in Ocean Waters. The reevaluation of proposed dredged material from the Arthur Kill project areas consisted of benthic acute toxicity tests. Thirty-three individual sediment core samples were collected from the Arthur Kill project area. Three composite sediments, representing each reach of the area proposed for dredging, was used in benthic acute toxicity testing. Benthic acute toxicity tests were performed with the amphipod Ampelisca abdita and the mysid Mysidopsis bahia. The amphipod and mysid benthic toxicity test procedures followed EPA guidance for reduction of total ammonia concentrations in test systems prior to test initiation. Statistically significant acute toxicity was found in all Arthur Kill composites in the static renewal tests with A. abdita, but not in the static tests with M. bahia. Statistically significant acute toxicity and a greater than 20% increase in mortality over the reference sediment was found in the static renewal tests with A. abdita. M. bahia did not show statistically significant acute toxicity or a greater than 10% increase in mortality over reference sediment in static tests. 5 refs., 2 figs., 2 tabs.

  19. Archaeological Investigation in the Perry Lake Project Area, Northeastern Kansas National Register Evaluation of 17 Sites

    DTIC Science & Technology

    1989-01-01

    a number of current research problems concerning the nature of the relationship among the various Plains Village populations in this part of the...Society devoted two seasons (1965 and 1967) to intensive excavations at a number of sites in the northern part of the project area under contract with the...The variability in the ceramic assemblage from the Bowies Branch site may provide answers to a number of current research problems concerning the

  20. Proposal to market Provo River Project power, Salt Lake City area

    SciTech Connect

    Not Available

    1995-01-01

    This report is an environmental assessment of the Western Area Power Administrations`s proposal to change the way in which the power produced by the Provo River Project (PRP) is marketed. The topics of the report include the alternatives to the proposed action that have been considered, a description of the environmental consequences of the proposed action and the alternatives that were considered, and other environmental considerations.

  1. Evaluation of dredged material proposed for ocean disposal from Bronx River Project Area, New York

    SciTech Connect

    Gruendell, B.D.; Gardiner, W.W.; Antrim, L.D.; Pinza, M.R.; Barrows, E.S.; Borde, A.B.

    1996-12-01

    The objective of the Bronx River project was to evaluate proposed dredged material from the Bronx River project area in Bronx, New York, to determine its suitability for unconfined ocean disposal at the Mud Dump Site. Bronx River was one of five waterways that the US Army Corps of Engineers-New York District (USAGE-NYD) requested the Battelle Marine Sciences Laboratory (MSL) to sample and to evaluate for dredging and disposal. Sediment samples were submitted for physical and chemical analyses, chemical analyses of dredging site water and elutriate, benthic and water-column acute toxicity tests, and bioaccumulation studies. Fifteen individual sediment core samples collected from the Bronx River project area were analyzed for grain size, moisture content, and total organic carbon (TOC). One composite sediment sample, representing the entire reach of the area proposed for dredging, was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAH), and 1,4- dichlorobenzene. Dredging site water and elutriate water, which was prepared from the suspended-particulate phase (SPP) of the Bronx River sediment composite, were analyzed for metals, pesticides, and PCBS.

  2. Area 5 Site Characterization Project: Report of hydraulic property analysis through August 1993

    SciTech Connect

    Estrella, R.; Tyler, S.; Chapman, J.; Miller, M.

    1993-12-01

    The Area 5 Site Characterization Project is designed to determine the suitability of the Radioactive Waste Management Site (RWMS) for disposal of low-level waste (LLW), mixed waste (MW) and transuranic waste (TRU). The Desert Research Institute (DRI) has supported the Area 5 Site Characterization Project for the US Department of Energy, Nevada Operations Office (DOE/NV), Environmental Restoration and Waste Management Division (ERWM), Waste Operations Branch (WOB). The purpose of DRI`s Area 5 Site Characterization project is to characterize important properties of the upper vadose zone which influence infiltration and redistribution of water and transport of solutes as well as to characterize the water quality and hydrologic conditions of the uppermost aquifer. This report describes methods and presents a summary of all data and results from laboratory physical and chemical testing from Pilot Wells and Science Trench borehole samples through August 1993. DRI laboratories performed soil water content, soil water potential, soil bulk density, soil water extract isotope analyses and soil water chemistry analyses.

  3. Optimizing hourly hydro operations at the Salt Lake City Area integrated projects

    SciTech Connect

    Veselka, T.D.; Hamilton, S.; McCoy, J.

    1995-06-01

    The Salt Lake City Area (SLCA) office of the Western Area Power Administration (Western) is responsible for marketing the capacity and energy generated by the Colorado Storage, Collbran, and Rio Grande hydropower projects. These federal resources are collectively called the Salt Lake City Area Integrated Projects (SLCA/IP). In recent years, stringent operational limitations have been placed on several of these hydropower plants including the Glen Canyon Dam, which accounts for approximately 80% of the SLCA/IP resources. Operational limitations on SLCA/IP hydropower plants continue to evolve as a result of decisions currently being made in the Glen Canyon Dam Environmental Impact Statement (EIS) and the Power Marketing EIS. To analyze a broad range of issues associated with many possible future operational restrictions, Argonne National Laboratory (ANL), with technical assistance from Western has developed the Hydro LP (Linear Program) Model. This model simulates hourly operations at SLCA/IP hydropower plants for weekly periods with the objective of maximizing Western`s net revenues. The model considers hydropower operations for the purpose of serving SLCA firm loads, loads for special projects, Inland Power Pool (IPP) spinning reserve requirements, and Western`s purchasing programs. The model estimates hourly SLCA/IP generation and spot market activities. For this paper, hourly SLCA/IP hydropower plant generation is simulated under three operational scenarios and three hydropower conditions. For each scenario an estimate of Western`s net revenue is computed.

  4. Project scheduling: A multi-objective evolutionary algorithm that optimizes the effectiveness of human resources and the project makespan

    NASA Astrophysics Data System (ADS)

    Yannibelli, Virginia; Amandi, Analía

    2013-01-01

    In this article, the project scheduling problem is addressed in order to assist project managers at the early stage of scheduling. Thus, as part of the problem, two priority optimization objectives for managers at that stage are considered. One of these objectives is to assign the most effective set of human resources to each project activity. The effectiveness of a human resource is considered to depend on its work context. The other objective is to minimize the project makespan. To solve the problem, a multi-objective evolutionary algorithm is proposed. This algorithm designs feasible schedules for a given project and evaluates the designed schedules in relation to each objective. The algorithm generates an approximation to the Pareto set as a solution to the problem. The computational experiments carried out on nine different instance sets are reported.

  5. 3-D diffusion tensor axonal tracking shows distinct SMA and pre-SMA projections to the human striatum.

    PubMed

    Lehéricy, Stéphane; Ducros, Mathieu; Krainik, Alexandre; Francois, Chantal; Van de Moortele, Pierre-François; Ugurbil, Kamil; Kim, Dae-Shik

    2004-12-01

    Studies in non-human primates have shown that medial premotor projections to the striatum are characterized as a set of distinct circuits conveying different type of information. This study assesses the anatomical projections from the supplementary motor area (SMA), pre-SMA and motor cortex (MC) to the human striatum using diffusion tensor imaging (DTI) axonal tracking. Eight right-handed volunteers were studied at 1.5 T using DTI axonal tracking. A connectivity matrix was computed, which tested for connections between cortical areas (MC, SMA and pre-SMA) and subcortical areas (posterior, middle and anterior putamen and the head of the caudate nucleus) in each hemisphere. Pre-SMA projections to the striatum were located rostral to SMA projections to the striatum. The SMA and the MC were similarly connected to the posterior and middle putamen and not to the anterior striatum. These data show that the MC and SMA have connections with similar parts of the sensorimotor compartment of the human striatum, whereas the pre-SMA sends connections to more rostral parts of the striatum, including the associative compartment.

  6. Human Genome Diversity Project. Summary of planning workshop 3(B): Ethical and human-rights implications

    SciTech Connect

    1993-12-31

    The third planning workshop of the Human Genome Diversity Project was held on the campus of the US National Institutes of Health in Bethesda, Maryland, from February 16 through February 18, 1993. The second day of the workshop was devoted to an exploration of the ethical and human-rights implications of the Project. This open meeting centered on three roundtables, involving 12 invited participants, and the resulting discussions among all those present. Attendees and their affiliations are listed in the attached Appendix A. The discussion was guided by a schedule and list of possible issues, distributed to all present and attached as Appendix B. This is a relatively complete, and thus lengthy, summary of the comments at the meeting. The beginning of the summary sets out as conclusions some issues on which there appeared to be widespread agreement, but those conclusions are not intended to serve as a set of detailed recommendations. The meeting organizer is distributing his recommendations in a separate memorandum; recommendations from others who attended the meeting are welcome and will be distributed by the meeting organizer to the participants and to the Project committee.

  7. 75 FR 27808 - Section 8 Housing Choice Voucher Program-Demonstration Project of Small Area Fair Market Rents in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-18

    ... the Housing Choice Voucher (HCV) program, to determine initial renewal rents for some expiring project... small area FMRs for the HCV program within certain metropolitan areas, and requests comments on several... calculated for the Demonstration projects will be used only in the Section 8 HCV program and will not...

  8. Region-to-area screening methodology for the Crystalline Repository Project

    SciTech Connect

    1985-04-01

    The purpose of this document is to describe the Crystalline Repository Project's (CRP) process for region-to-area screening of exposed and near-surface crystalline rock bodies in the three regions of the conterminous United States where crystalline rock is being evaluated as a potential host for the second nuclear waste repository (i.e., in the North Central, Northeastern, and Southeastern Regions). This document indicates how the US Department of Energy's (DOE) General Guidelines for the Recommendation of Sites for Nuclear Waste Repositories (10 CFR 960) were used to select and apply factors and variables for the region-to-area screening, explains how these factors and variable are to be applied in the region-to-area screening, and indicates how this methodology relates to the decision process leading to the selection of candidate areas. A brief general discussion of the screening process from the national survey through area screening and site recommendation is presented. This discussion sets the scene for detailed discussions which follow concerning the region-to-area screening process, the guidance provided by the DOE Siting Guidelines for establishing disqualifying factors and variables for screening, and application of the disqualifying factors and variables in the screening process. This document is complementary to the regional geologic and environmental characterization reports to be issued in the summer of 1985 as final documents. These reports will contain the geologic and environmental data base that will be used in conjunction with the methodology to conduct region-to-area screening.

  9. B-Vitamin Levels in Human Milk among Different Lactation Stages and Areas in China.

    PubMed

    Ren, Xiangnan; Yang, Zhenyu; Shao, Bing; Yin, Shi-An; Yang, Xiaoguang

    2015-01-01

    To determine the contents of B-vitamins in human milk in China, we analyzed 1778 human milk samples from the sample bank of the National High Technique R & D Program (863 Projects) which was a cross-sectional survey and covered 6419 human milk samples from healthy lactating mothers who were at different stages of lactation (0-330 days postpartum) in 11 provinces of China. The contents of free forms of six B-vitamins in these human milk samples were analyzed by using UPLC-MS/MS. The median concentrations of free form of 6 B-vitamins in colostrums, transitional milk, 15-180 d mature milk and 181-330 d mature milk were respectively as follows: thiamin 5.0 µg/L, 6.7 µg/L, 21.1 µg/L and 40.7 µg/L; riboflavin 29.3 µg/L, 40.6 µg/L, 33.6 µg/L and 29.6 µg/L; niacin 470.7 µg/L, 661.3 µg/L, 687.0 µg/L and 571.3 µg/L; vitamin B-6 4.6 µg/L, 16.1 µg/L, 62.7 µg/L and 80.7 µg/L; flavin adenine dinucleotide (FAD) 808.7 µg/L, 1162.8 µg/L, 1023.9 µg/L and 1057.2 µg/L; pantothenic acid 1770.9 µg/L, 2626.8 µg/L, 2213.0 µg/L and 1895.5 µg/L. The contents of 6 B-vitamins varied significantly among the different lactation stages and different areas (coastal area vs inland area, rural area vs urban area). The present study indicated that the concentrations of B-vitamins in colostrum were generally much lower than those in transitional milk and mature milk. Further studies are warranted for their roles and significance on B-vitamins in colostrum in nutrition and metabolism of neonates.

  10. Neurochemical, morphologic, and laminar characterization of cortical projection neurons in the cingulate motor areas of the macaque monkey

    NASA Technical Reports Server (NTRS)

    Nimchinsky, E. A.; Hof, P. R.; Young, W. G.; Morrison, J. H.; Bloom, F. E. (Principal Investigator)

    1996-01-01

    The primate cingulate gyrus contains multiple cortical areas that can be distinguished by several neurochemical features, including the distribution of neurofilament protein-enriched pyramidal neurons. In addition, connectivity and functional properties indicate that there are multiple motor areas in the cortex lining the cingulate sulcus. These motor areas were targeted for analysis of potential interactions among regional specialization, connectivity, and cellular characteristics such as neurochemical profile and morphology. Specifically, intracortical injections of retrogradely transported dyes and intracellular injection were combined with immunocytochemistry to investigate neurons projecting from the cingulate motor areas to the putative forelimb region of the primary motor cortex, area M1. Two separate groups of neurons projecting to area M1 emanated from the cingulate sulcus, one anterior and one posterior, both of which furnished commissural and ipsilateral connections with area M1. The primary difference between the two populations was laminar origin, with the anterior projection originating largely in deep layers, and the posterior projection taking origin equally in superficial and deep layers. With regard to cellular morphology, the anterior projection exhibited more morphologic diversity than the posterior projection. Commissural projections from both anterior and posterior fields originated largely in layer VI. Neurofilament protein distribution was a reliable tool for localizing the two projections and for discriminating between them. Comparable proportions of the two sets of projection neurons contained neurofilament protein, although the density and distribution of the total population of neurofilament protein-enriched neurons was very different in the two subareas of origin. Within a projection, the participating neurons exhibited a high degree of morphologic heterogeneity, and no correlation was observed between somatodendritic morphology and

  11. Evaluation of dredged material proposed for ocean disposal from Westchester Creek project area, New York

    SciTech Connect

    Pinza, M.R.; Gardiner, W.W.; Barrows, E.S.; Borde, A.B.

    1996-11-01

    The objective of the Westchester Creek project was to evaluate proposed dredged material from this area to determine its suitability for unconfined ocean disposal at the Mud Dump Site. Westchester Creek was one of five waterways that the US Army Corps of Engineers- New York District (USACE-NYD) requested the Battelle/Marine Sciences Laboratory (MSL) to sample and evaluate for dredging and disposal in May 1995. The evaluation of proposed dredged material from the Westchester Creek project area consisted of bulk sediment chemical analyses, chemical analyses of dredging site water and elutriate, benthic acute and water-column toxicity tests, and bioaccumulation studies. Thirteen individual sediment core samples were collected from this area and analyzed for grain size, moisture content, and total organic carbon (TOC). One composite sediment sample representing the Westchester Creek area to be dredged, was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAHs), and 1,4-dichlorobenzene. Dredging site water and elutriate water, which is prepared from the suspended- particulate phase (SPP) of the Westchester Creek sediment composite, was analyzed for metals, pesticides, and PCBS.

  12. Data dictionary services in XNAT and the Human Connectome Project.

    PubMed

    Herrick, Rick; McKay, Michael; Olsen, Timothy; Horton, William; Florida, Mark; Moore, Charles J; Marcus, Daniel S

    2014-01-01

    The XNAT informatics platform is an open source data management tool used by biomedical imaging researchers around the world. An important feature of XNAT is its highly extensible architecture: users of XNAT can add new data types to the system to capture the imaging and phenotypic data generated in their studies. Until recently, XNAT has had limited capacity to broadcast the meaning of these data extensions to users, other XNAT installations, and other software. We have implemented a data dictionary service for XNAT, which is currently being used on ConnectomeDB, the Human Connectome Project (HCP) public data sharing website. The data dictionary service provides a framework to define key relationships between data elements and structures across the XNAT installation. This includes not just core data representing medical imaging data or subject or patient evaluations, but also taxonomical structures, security relationships, subject groups, and research protocols. The data dictionary allows users to define metadata for data structures and their properties, such as value types (e.g., textual, integers, floats) and valid value templates, ranges, or field lists. The service provides compatibility and integration with other research data management services by enabling easy migration of XNAT data to standards-based formats such as the Resource Description Framework (RDF), JavaScript Object Notation (JSON), and Extensible Markup Language (XML). It also facilitates the conversion of XNAT's native data schema into standard neuroimaging vocabularies and structures.

  13. The chromosome-centric human proteome project at FEBS Congress.

    PubMed

    Ponomarenko, Elena; Baranova, Ancha; Lisitsa, Andrey; Albar, Juan Pablo; Archakov, Alexander

    2014-02-01

    In the summer of 2013, distinguished global representatives of proteome science gathered to discuss the futuristic visions of the chromosome-centric human proteome project (C-HPP) (Cochairs: Y. K. Paik, G. Omenn; hosted by A. Archakov, Institute of Biomedical Chemistry, Russia) that was broadcast to the annual Federation of European Biochemical Societies Congress (St. Petersburg, Russia, July 10-11, 2013). Technology breakthroughs presented included a new ultra-sensitive Tribrid mass-spectrometer from Thermo and SOMAmers-Slow Off-rate Modified Aptamers (SOMAlogic, USA), a new type of protein capture reagents. Professor Archakov's group introduced the "rectangle" concept of proteome size as a product of proteome width and depth. The discussion on proteome width culminated with the introduction of digital biomarkers-low-copied aberrant proteins that differ from their typical forms by PTMs, alternative splicing, or single amino acid polymorphisms. The aberrant proteoforms, a complement to whole-genome proteomic surveys, were presented as an ultimate goal for the proteomic community.

  14. Human Variome Project Quality Assessment Criteria for Variation Databases.

    PubMed

    Vihinen, Mauno; Hancock, John M; Maglott, Donna R; Landrum, Melissa J; Schaafsma, Gerard C P; Taschner, Peter

    2016-06-01

    Numerous databases containing information about DNA, RNA, and protein variations are available. Gene-specific variant databases (locus-specific variation databases, LSDBs) are typically curated and maintained for single genes or groups of genes for a certain disease(s). These databases are widely considered as the most reliable information source for a particular gene/protein/disease, but it should also be made clear they may have widely varying contents, infrastructure, and quality. Quality is very important to evaluate because these databases may affect health decision-making, research, and clinical practice. The Human Variome Project (HVP) established a Working Group for Variant Database Quality Assessment. The basic principle was to develop a simple system that nevertheless provides a good overview of the quality of a database. The HVP quality evaluation criteria that resulted are divided into four main components: data quality, technical quality, accessibility, and timeliness. This report elaborates on the developed quality criteria and how implementation of the quality scheme can be achieved. Examples are provided for the current status of the quality items in two different databases, BTKbase, an LSDB, and ClinVar, a central archive of submissions about variants and their clinical significance.

  15. Project Columbiad: Reestablishment of human presence on the Moon

    NASA Technical Reports Server (NTRS)

    Shea, Joseph; Weiss, Stanley; Alexander, Harold; Belobaba, Peter; Loboda, Greg; Berry, Maresi; Bower, Mark; Bruen, Charles; Cazeau, Patrick; Clarke, Michael

    1992-01-01

    In response to the Report of the Advisory Committee on the future of the U.S. Space Program and a request from NASA's Exploration Office, the MIT Hunsaker Aerospace Corporation (HAC) conducted a feasibility study, known as Project Columbiad, on reestablishing human presence on the Moon before the year 2000. The mission criteria established were to transport a four person crew to the lunar surface at any latitude and back to Earth with a 14-28 day stay on the lunar surface. Safety followed by cost of the Columbiad Mission were the top level priorities of HAC. The resulting design has a precursor mission that emplaces the required surface payloads before the piloted mission arrives. Both the precursor and piloted missions require two National Launch System (NLS) launches. Both the precursor and piloted missions have an Earth orbit rendezvous (EOR) with a direct transit to the Moon post-EOR. The piloted mission returns to Earth via a direct transit. Included among the surface payloads preemplaced are a habitat, solar power plant (including fuel cells for the lunar night), lunar rover, and mecanisms used to cover the habitat with regolith (lunar soil) in order to protect the crew members from severe solar flare radiation.

  16. Long-distance feedback projections to area V1: implications for multisensory integration, spatial awareness, and visual consciousness.

    PubMed

    Clavagnier, Simon; Falchier, Arnaud; Kennedy, Henry

    2004-06-01

    It is generally agreed that information flow through the cortex is constrained by a hierarchical architecture. Recent experimental evidence suggests that projections descending the hierarchy and targeting the primary visual cortex (area V1) may play an essential role in perceptual processes. We have, therefore, reexamined feedback projections to area V1, using retrograde tracer injections in this area In addition to well-known areas, quantification of labeling in higher cortical areas reveals a number of hitherto unknown long-distance feedback connections originating from auditory (A1), multisensory (STP) cortices, but also from a perirhinal area (36). These feedback projections from advanced cortical stations, a global feature shared by areas that belong to the ventral visual stream, could play an important role in early multisensory integration and spatial awareness and could provide the physical substrate for the involvement of area V1 in visual consciousness.

  17. Stormwater Pollution Prevention Plan (SWPPP) for Coal Storage Area Stabilization Project

    SciTech Connect

    Project and Design Engineering

    2011-03-01

    The scope of this project is to stabilize the abandoned coal storage area and redirect the storm water runoff from sanitary sewer system to the storm drain system. Currently, the existing storm water runoff is directed to a perimeter concrete drainage swale and collected in a containment basin. The collected water is then pumped to a treatment facility and after treatment, is discharged to the Y-12 sanitary sewer system. The existing drainage swale and collection basin along with silt fencing will be used during aggregate placement and grading to provide erosion and sediment control. Inlet protection will also be installed around existing structures during the storm water diversion construction. This project scope will include the installation of a non-woven geotextile fabric and compacted mineral aggregate base (paving optional) to stabilize the site. The geotextile specifications are provided on the vendor cut sheets in Appendix B. The installation of a storm water collection/retention area will also be installed on the southern side of the site in accordance with EPA Technical Guidance on Implementing the Stormwater Runoff Requirements for federal Projects under Section 438 of the Energy Independence and Security Act. The total area to be disturbed is approximately 2.5 acres. The order of activities for this Stormwater Pollution Prevention Plan (SWPPP) will be: (1) post notice of coverage (NOC) in a prominent display near entrance of the site; (2) install rain gauge on site or contact Y-12 Plant Shift Superintendent daily for Met tower rain gauge readings; (3) install stabilized construction exit on site; (4) install silt fencing along perimeter as indicated on the attached site plan; (5) regrade site; (6) install geotextile fabric and compacted mineral aggregate base; (7) install catch basin inlet protection where required; (8) excavate and lower existing catch basin tops, re-grade and asphalt to drain; and (9) when all disturbed areas are re-stabilized, remove

  18. Delayed response to animate implied motion in human motion processing areas.

    PubMed

    Lorteije, Jeannette A M; Kenemans, J Leon; Jellema, Tjeerd; van der Lubbe, Rob H J; de Heer, Frederiek; van Wezel, Richard J A

    2006-02-01

    Viewing static photographs of objects in motion evokes higher fMRI activation in the human medial temporal complex (MT+) than looking at similar photographs without this implied motion. As MT+ is traditionally thought to be involved in motion perception (and not in form perception), this finding suggests feedback from object-recognition areas onto MT+. To investigate this hypothesis, we recorded extracranial potentials evoked by the sight of photographs of biological agents with and without implied motion. The difference in potential between responses to pictures with and without implied motion was maximal between 260 and 400 msec after stimulus onset. Source analysis of this difference revealed one bilateral, symmetrical dipole pair in the occipital lobe. This area also showed a response to real motion, but approximately 100 msec earlier than the implied motion response. The longer latency of the implied motion response in comparison to the real motion response is consistent with a feedback projection onto MT+ following object recognition in higher-level temporal areas.

  19. Evaluation of dredged material proposed for ocean Disposal from Shoal Harbor/Compton Creek Project Area

    SciTech Connect

    Gardiner, W.W.; Borde, A.B.; Nieukirk, S.L.; Barrows, E.S.; Gruendell, B.D.; Word, J.Q.

    1996-10-01

    The objective of the Shoal Harbor/Compton Creek Project was to evaluate proposed dredged material from the Shoal harbor/Compton Creek Project Area in Belford and Monmouth, New Jersey to determine its suitability for unconfined ocean disposal at the Mud Dump Site. This was one of five waterways that the US Army Corps of Engineers- New York District requested the Battelle Marine Sciences Laboratory (MSL) to sample and evaluate for dredging and disposal in May 1995. The evaluation of proposed dredged material from the Shoal Harbor/Compton Creek Project area consisted of bulk chemical analyses, chemical analyses of dredging site water and elutriate, benthic and water-column acute toxicity tests and bioaccumulation studies. Eleven core samples were analyzed or grain size, moisture content, and total organic carbon. Other sediments were evaluated for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congers, polynuclear aromatic hydrocarbons, and 1,4- dichlorobenzene. Dredging site water and elutriate water were analyzed for metals, pesticides, and PCBs.

  20. Documentation of the Range 8C rehabilitation demonstration project at Hohenfels Training Area, West Germany

    SciTech Connect

    Zellmer, S.D.; Hinchman, R.R.; Carter, R.P.; Severinghaus, W.D.; Lacey, R.M.; Brent, J.J.

    1987-03-01

    Continued and intensive tactical training for the last 35 years at the Hohenfels Training Area (HTA), Federal Republic of Germany, has resulted in extensive environmental damage and reduced training realism. The US Corps of Engineers Construction Engineering Research Laboratory is developing an Integrated Training Area Management (ITAM) Program for the Seventh Army Training Command for use at HTA. Argonne National Laboratory was asked to assist in one element of the ITAM program, a training range rehabilitation demonstration project. The rehabilitation project was begun in 1986 on a 62-ha watershed that included about 16 ha of meadow with training damage typical of HTA. On the basis of amount of plant ground cover, type and degree of erosion, and soil properties, 10 rehabilitation prescriptions were developed to reestablish plant cover, control erosion, and improve training realism. Prescriptions were installed by a local contractor in September 1986. A monitoring program is under way to determine the effectiveness of this effort. Results and experience gained from this project will be used in the ITAM program and for rehabilitation training courses conducted at HTA.

  1. Impacts of China's Three Gorges Dam Project on net primary productivity in the reservoir area.

    PubMed

    Xu, Xibao; Tan, Yan; Yang, Guishan; Li, Hengpeng; Su, Weizhong

    2011-10-15

    China's Three Gorges Dam Project (TGP) is the world's largest hydroelectric power project, and as a consequence the reservoir area is at risk of ecological degradation. This study uses net primary productivity (NPP) as an important indicator of the reservoir ecosystem's productivity to estimate the impacts of the TGP in the local resettlement region of the Three Gorges Reservoir Area (TGRA) over the 2000-2010 period. The modeling method is based upon the Carnegie Ames Stanford Approach (CASA) terrestrial carbon model and uses Moderate Resolution Imaging Spectroradiometer (MODIS) remote sensing data for modeling simulation. The results demonstrate that total NPP in the resettlement region decreased by 8.0% (632.8Gg) from 2000 to 2010. The impact of the TGP on NPP is mainly mediated by land-use change brought about by the large-scale inundation of land and subsequent massive resettlement of both rural and urban residents. Nearby resettlement, land inundation, and relocation of old urban centers and affiliated urban dwellers are responsible for 54.3%, 28.0%, and 5.8% respectively of total NPP reduction in the resettlement region over the study period. The major national ecological projects implemented in the TGRA since 1998 have played a key role in offsetting the negative impacts of the TGP on NPP in the region.

  2. Efferent projection from the rostral ventrolateral medulla to the area postrema in rats.

    PubMed

    Frugière, A; Nunez, E; Pasaro, R; Gaytan, S; Barillot, J C

    1998-08-06

    The rostral ventrolateral medulla (RVLM) is a region of the brain primarily involved in cardiovascular control. It receives information from several areas of the brainstem, among which the area postrema (AP) and the nucleus of the solitary tract (NTS). The medial subnuclei of the solitary tract (TS) project towards the RVLM, providing cardiopulmonary information, and the AP serves information about circulatory hormones. Although the efferent pathways are well known, it is not the case for the connections from the RVLM towards the AP and the NTS. The present study was designed to examine the efferent connections from the RVLM onto the dorsal structures of the medulla: quantitatively by means of anatomical techniques, and functionally by means of electrophysiological techniques. Morphologically, Biocytin or Biotinylated dextran amine microinjections into the RVLM were followed by labelling of many fibres running towards the bulbar dorsomedial structures, with some pathways lying in the AP itself, or located in its caudal vicinity. Conversely, when microinjections of Fast Blue (FB) were made into the AP, FB-labelled cells could be observed within the RVLM. Electrophysiologically, single shock stimulation carried on AP allowed identification of axonal fibres issuing from somata located into the cardiovascular neuronal pool in the RVLM. From these results, we can assume: (1) the existence of dense efferent projection from RVLM to aspects of the dorsal vagal complex, including the AP and, among this dense projection, (2) the existence of some fibres terminating in, or crossing through the AP, and identified as conveying baroreceptor-related information, in the rat.

  3. The Human Genome Project: Information access, management, and regulation. Final report

    SciTech Connect

    McInerney, J.D.; Micikas, L.B.

    1996-08-31

    The Human Genome Project is a large, internationally coordinated effort in biological research directed at creating a detailed map of human DNA. This report describes the access of information, management, and regulation of the project. The project led to the development of an instructional module titled The Human Genome Project: Biology, Computers, and Privacy, designed for use in high school biology classes. The module consists of print materials and both Macintosh and Windows versions of related computer software-Appendix A contains a copy of the print materials and discs containing the two versions of the software.

  4. A Program to Strengthen Early Childhood Education in Poverty Area Schools; Project No. 0769. Evaluation of ESEA Title I Projects in New York City 1968-69.

    ERIC Educational Resources Information Center

    Almeida, Cynthia H.

    The Program to Strengthen Early Childhood Education in poverty area schools in New York City, a Title I ESEA project, was designed to continue the efforts of Project Headstart into the primary grades. The program attempted to improve the achievement level of primary grade pupils by introducing reduced class ratios, paraprofessional assistance, and…

  5. Eld's deer translocated to human-inhabited areas become nocturnal.

    PubMed

    Pan, Duo; Teng, Liwei; Cui, Fangjie; Zeng, Zhigao; Bravery, Benjamin D; Zhang, Qiong; Song, Yanling

    2011-02-01

    As human populations expand and nonhuman animals decline, understanding the interactions between people and wildlife is essential. For endangered species, appreciating the effect of human disturbance can be important for their conservation. However, a human disturbance angle is often absent from ecological research, despite growing evidence of the negative impact of nonfatal human interference. Here, we monitored Hainan Eld's deer living within a reserve and translocated animals living amongst villagers. We show that translocated deer deviated from a crepuscular activity pattern and became increas-. ingly nocturnal, and most active when villagers were not. It appears that translocated deer adapted over time to human disturbance and this pattern is similar to that of other species during periods of hunting. People do not pose an actual threat to Eld's deer, but their presence triggered a response akin to predator avoidance and may be interfering with broader aspects of their biology and conservation.

  6. Tackling five main problem areas found in science (ground segment) project developments

    NASA Astrophysics Data System (ADS)

    Lock, T.; Pérez-López, F.

    2014-08-01

    Science projects which require a large software development may use many scientists alongside a few professional software engineers. Such projects tend to show extreme cases of the general problems associated with software developments. After introducing an example of a large software development in a science project, the importance of a development management plan will be emphasised and sections of the plan highlighted and it is explained how these sections address and prepare for the expected problems throughout the life of the project. A positive, strongly proactive quality assurance, QA, approach is the common theme throughout. The role of QA is, therefore, more to guide, support and advise all members of the team rather than only to detect and react to problems. The top five problem areas addressed are: 1. Vague, late and missing requirements. 2. Few professional software engineers in a large software development. 3. A lack of testers with an appropriate test mentality. 4. Quality Assurance people cannot be everywhere, nor have in-depth skills in every subject. 5. Scientists will want to start coding and see writing documents as a waste of their time.

  7. Area-specific development of distinct projection neuron subclasses is regulated by postnatal epigenetic modifications.

    PubMed

    Harb, Kawssar; Magrinelli, Elia; Nicolas, Céline S; Lukianets, Nikita; Frangeul, Laura; Pietri, Mariel; Sun, Tao; Sandoz, Guillaume; Grammont, Franck; Jabaudon, Denis; Studer, Michele; Alfano, Christian

    2016-01-27

    During cortical development, the identity of major classes of long-distance projection neurons is established by the expression of molecular determinants, which become gradually restricted and mutually exclusive. However, the mechanisms by which projection neurons acquire their final properties during postnatal stages are still poorly understood. In this study, we show that the number of neurons co-expressing Ctip2 and Satb2, respectively involved in the early specification of subcerebral and callosal projection neurons, progressively increases after birth in the somatosensory cortex. Ctip2/Satb2 postnatal co-localization defines two distinct neuronal subclasses projecting either to the contralateral cortex or to the brainstem suggesting that Ctip2/Satb2 co-expression may refine their properties rather than determine their identity. Gain- and loss-of-function approaches reveal that the transcriptional adaptor Lmo4 drives this maturation program through modulation of epigenetic mechanisms in a time- and area-specific manner, thereby indicating that a previously unknown genetic program postnatally promotes the acquisition of final subtype-specific features.

  8. Area-specific development of distinct projection neuron subclasses is regulated by postnatal epigenetic modifications

    PubMed Central

    Harb, Kawssar; Magrinelli, Elia; Nicolas, Céline S; Lukianets, Nikita; Frangeul, Laura; Pietri, Mariel; Sun, Tao; Sandoz, Guillaume; Grammont, Franck; Jabaudon, Denis; Studer, Michèle; Alfano, Christian

    2016-01-01

    During cortical development, the identity of major classes of long-distance projection neurons is established by the expression of molecular determinants, which become gradually restricted and mutually exclusive. However, the mechanisms by which projection neurons acquire their final properties during postnatal stages are still poorly understood. In this study, we show that the number of neurons co-expressing Ctip2 and Satb2, respectively involved in the early specification of subcerebral and callosal projection neurons, progressively increases after birth in the somatosensory cortex. Ctip2/Satb2 postnatal co-localization defines two distinct neuronal subclasses projecting either to the contralateral cortex or to the brainstem suggesting that Ctip2/Satb2 co-expression may refine their properties rather than determine their identity. Gain- and loss-of-function approaches reveal that the transcriptional adaptor Lmo4 drives this maturation program through modulation of epigenetic mechanisms in a time- and area-specific manner, thereby indicating that a previously unknown genetic program postnatally promotes the acquisition of final subtype-specific features. DOI: http://dx.doi.org/10.7554/eLife.09531.001 PMID:26814051

  9. Large Area Projection Microstereolithography: Characterization and Optimization of 3D Printing Parameters

    SciTech Connect

    Ng, Melissa R.; Moran, Bryan; Bekker, Logan; Dudukovic, Nikola

    2016-08-12

    Large Area Projection Microstereolithography (LAPμSL) is a new technology that allows the additive manufacture of parts that have feature sizes spanning from centimeters to tens of microns. Knowing the accuracy of builds from a system like this is a crucial step in development. This project explored the capabilities of the second and newest LAPμSL system that was built by comparing the features of actual builds to the desired structures. The system was then characterized in order to achieve the best results. The photo polymeric resins that were used were Autodesk PR48 and HDDA. Build parameters for Autodesk PR48 were found that allowed the prints to progress while using the full capacity of the system to print quality parts in a relatively short amount of time. One of the larger prints in particular had a print time that was nearly eighteen times faster than it would have been had printed in the first LAPμSL system. The characterization of HDDA resin helped the understanding that the flux of the light projected into the resin also affected the quality of the builds, rather than just the dose of light given. Future work for this project includes exploring the use of other resins in the LAPμSL systems, exploring the use of Raman Spectroscopy to analyze builds, and completing the characterization of the LAPμSL system.

  10. Relationships between Western Area Power Administration`s power marketing program and hydropower operations at Salt Lake City area integrated projects

    SciTech Connect

    Veselka, T.D.; Folga, S.; Poch, L.A.

    1995-03-01

    This technical memorandum provides background information on the Western Area Power Administration (Western) and the physical characteristics of the Salt Lake City Area Integrated Projects (SLCA/IP) hydropower plants, which include the Colorado River Storage Project, the Rio Grande Project, and the Collbran Project. In addition, the history, electrical capacity, storage capacity, and flow restrictions at each dam are presented. An overview of Western`s current programs and services, including a review of statutory authorities, agency discretion, and obligations, is also provided. The variability of SLCA/IP hourly generation under various alternative marketing strategies and purchasing programs is discussed. The effects of Western`s services, such as area load control, outage assistance, and transmission, on SLCA/IP power plant operations are analyzed.

  11. Corrective Action Investigation Plan for Corrective Action Unit 447: Project Shoal Area, Nevada Subsurface Site

    SciTech Connect

    DOE /NV

    1998-11-01

    This Corrective Action Investigation Plan (CAIP) describes the US Department of Energy's (DOE's) continued environmental investigation of the subsurface Project Shoal Area (PSA) Corrective Action Unit (CAU) 447. The PSA is located in the Sand Springs Mountains in Churchill County, Nevada, about 48 kilometers (km) (30 miles [mi]) southeast of Fallon, Nevada. Project Shoal was part of the Vela Uniform Program which was conducted to improve the US' ability to detect, identify, and locate underground nuclear detonations. The test consisted of detonating a 12-kiloton nuclear device deep underground in granitic rock to determine whether seismic waves produced by an underground nuclear test could be differentiated from seismic waves produced by a naturally occurring earthquake. The test was a joint effort conducted by the US Atomic Energy Commission (AEC) and the US Department of Defense (DoD) in October 1963 (AEC, 1964).

  12. Projected impacts of climate change on a continent-wide protected area network.

    PubMed

    Hole, David G; Willis, Stephen G; Pain, Deborah J; Fishpool, Lincoln D; Butchart, Stuart H M; Collingham, Yvonne C; Rahbek, Carsten; Huntley, Brian

    2009-05-01

    Despite widespread concern, the continuing effectiveness of networks of protected areas under projected 21st century climate change is uncertain. Shifts in species' distributions could mean these resources will cease to afford protection to those species for which they were originally established. Using modelled projected shifts in the distributions of sub-Saharan Africa's entire breeding avifauna, we show that species turnover across the continent's Important Bird Area (IBA) network is likely to vary regionally and will be substantial at many sites (> 50% at 42% of IBAs by 2085 for priority species). Persistence of suitable climate space across the network as a whole, however, is notably high, with 88-92% of priority species retaining suitable climate space in >or= 1 IBA(s) in which they are currently found. Only 7-8 priority species lose climatic representation from the network. Hence, despite the likelihood of significant community disruption, we demonstrate that rigorously defined networks of protected areas can play a key role in mitigating the worst impacts of climate change on biodiversity.

  13. Personal genomes in progress: from the human genome project to the personal genome project.

    PubMed

    Lunshof, Jeantine E; Bobe, Jason; Aach, John; Angrist, Misha; Thakuria, Joseph V; Vorhaus, Daniel B; Hoehe, Margret R; Church, George M

    2010-01-01

    The cost of a diploid human genome sequence has dropped from about $70M to $2000 since 2007--even as the standards for redundancy have increased from 7x to 40x in order to improve call rates. Coupled with the low return on investment for common single-nucleotide polylmorphisms, this has caused a significant rise in interest in correlating genome sequences with comprehensive environmental and trait data (GET). The cost of electronic health records, imaging, and microbial, immunological, and behavioral data are also dropping quickly. Sharing such integrated GET datasets and their interpretations with a diversity of researchers and research subjects highlights the need for informed-consent models capable of addressing novel privacy and other issues, as well as for flexible data-sharing resources that make materials and data available with minimum restrictions on use. This article examines the Personal Genome Project's effort to develop a GET database as a public genomics resource broadly accessible to both researchers and research participants, while pursuing the highest standards in research ethics.

  14. Geological evaluation of San Diego Norte Pilot Project, Zuata area, Orinoco Oil Belt, Venezuela

    SciTech Connect

    De Rojas, I.

    1987-10-01

    The San Diego Norte Pilot Project consists of twelve inclined wells (7 producing wells 300 m (984 ft) apart, plus 5 observation wells) drilled from a cluster, to study the production and compaction behavior under steam soak (huff and puff) of the Tertiary heavy crude oil reservoirs of the Zuata area. This area is located within the Orinoco Heavy Oil belt of Venezuela. A geological model was needed as a base for the reservoir studies and to understand the geological setting. This model was constructed from extensive log information, seismic lines, well samples, and cores. The reservoir sands are friable with an average porosity of 34% and permeabilities ranging from 1 to 7 ..mu..m/sup 2/ (1 to 7 darcys). The sands were deposited in meander belts that stacked up forming multistory bodies. Point bars and channel fills account for 80-90% of the total sand. These sands are internally heterogeneous, sinuous and elongated, and larger than the 1 km/sup 2/ area covered by the project. The topmost two productive sands, which together average 22 m (72 ft), show the best porosities and permeabilities and are isolated by thick clays that make them suitable for selective steam injection. In the project, the oil has a density of about 1.0 g/cm/sup 3/ (10/sup 0/ API) and fills all the sands down to the oil-water contact. The depth of this contact is controlled by regional faults. Based on core compressibility tests, compaction is expected to be the principal production mechanism that could increase the expected primary recovery of 4 to 12% by huff and puff steam injection, leading to a possible recovery of 0.64 x 10/sup 6/ m/sup 3/ (4 million bbl) in six years with four cycles of steam injection. 16 figures, 2 tables.

  15. Rainwater Wildlife Area Management Plan Executive Summary : A Columbia Basin Wildlife Mitigation Project.

    SciTech Connect

    Childs, Allen B.

    2002-02-01

    This Executive Summary provides an overview of the Draft Rainwater Wildlife Area Management Plan. The comprehensive plan can be viewed on the Confederated Tribes of the Umatilla Indian Reservation (CTUIR) website at: www.umatilla.nsn.us or requested in hard copy from the CTUIR at the address below. The wildlife area was established in September 1998 when the CTUIR purchased the Rainwater Ranch through Bonneville Power Administration (BPA) for purposes of fish and wildlife mitigation for the McNary and John Day dams. The Management Plan has been developed under a standardized planning process developed by BPA for Columbia River Basin Wildlife Mitigation Projects (See Guiding Policies Section below). The plan outlines the framework for managing the project area, provides an assessment of existing conditions and key resource issues, and presents an array of habitat management and enhancement strategies. The plan culminates into a 5-Year Action Plan that will focus management actions and prioritize funding during the 2002-2006 planning period. Since acquisition of the property in late 1998, the CTUIR has conducted an extensive baseline resource assessment in preparation for the management plan, initiated habitat restoration in the Griffin Fork drainage to address road-related resource damage caused by roads constructed for forest practices and an extensive flood event in 1996, and initiated infrastructure developments associated with the Access and Travel Management Plan (i.e., installed parking areas, gates, and public information signs). In addition to these efforts, the CTUIR has worked to set up a long-term funding mechanism with BPA through the NPPC Fish and Wildlife Program. The CTUIR has also continued to coordinate closely with local and state government organizations to ensure consistency with local land use laws and maintain open lines of communication regarding important issues such as big game hunting, tribal member exercise of treaty rights, and public

  16. Project Work Plan: Hanford 100-D Area Treatability Demonstration - In Situ Biostimulation for Reducing Barrier

    SciTech Connect

    Fruchter, Jonathan S.; Truex, Michael J.; Vermeul, Vince R.; Long, Philip E.

    2006-05-31

    This work plan supports a new, integrated approach to accelerate cleanup of chromium in the Hanford 100 Areas. This new approach will provide supplemental treatment upgradient of the ISRM barrier by directly treating chromium and other oxidizing species in groundwater (i.e., nitrate and dissolved oxygen), thereby increasing the longevity of the ISRM barrier and protecting the ecological receptors and human health at the river boundary.

  17. St. Louis Area Earthquake Hazards Mapping Project - A PowerPoint Presentation

    USGS Publications Warehouse

    Williams, Robert A.

    2009-01-01

    This Open-File Report contains illustrative materials, in the form of PowerPoint slides, used for an oral presentation given at the Earthquake Insight St. Louis, Mo., field trip held on May 28, 2009. The presentation focused on summarizing the St. Louis Area Earthquake Hazards Mapping Project (SLAEHMP) justification, goals, achievements, and products, for an audience of business and public officials. The individual PowerPoint slides highlight, in an abbreviated format, the topics addressed; they are discussed below and are explained with additional text as appropriate.

  18. Procedures and results of the measurements on large area photomultipliers for the NEMO project

    NASA Astrophysics Data System (ADS)

    Aiello, S.; Leonora, E.; Aloisio, A.; Ameli, F.; Amore, I.; Anghinolfi, M.; Anzalone, A.; Barbarino, G.; Barbarito, E.; Battaglieri, M.; Bazzotti, M.; Bellotti, R.; Bersani, A.; Beverini, N.; Biagi, S.; Bonori, M.; Bouhdaef, B.; Cacopardo, G.; Calı, C.; Capone, A.; Caponetto, L.; Carminati, G.; Cassano, B.; Ceres, A.; Chiarusi, T.; Circella, M.; Cocimano, R.; Coniglione, R.; Cordelli, M.; Costa, M.; D'Amico, A.; DeBonis, G.; DeRosa, G.; DeRuvo, G.; DeVita, R.; Distefano, C.; Flaminio, V.; Fratini, K.; Gabrielli, A.; Galeotti, S.; Gandolfi, E.; Giacomelli, G.; Giorgi, F.; Giovanetti, G.; Grimaldi, A.; Grmek, A.; Habel, R.; Imbesi, M.; Lonardo, A.; LoPresti, D.; Lucarelli, F.; Margiotta, A.; Marinelli, A.; Martini, A.; Masullo, R.; Maugeri, F.; Migneco, E.; Minutoli, S.; Mongelli, M.; Morganti, M.; Musico, P.; Musumeci, M.; Orlando, A.; Osipenko, M.; Papaleo, R.; Pappalardo, V.; Piattelli, P.; Piombo, D.; Raffaelli, F.; Raia, G.; Randazzo, N.; Reito, S.; Ricco, G.; Riccobene, G.; Ripani, M.; Rovelli, A.; Ruppi, M.; Russo, G. V.; Russo, S.; Sapienza, P.; Sedita, M.; Shirokov, E.; Simeone, F.; Sciliberto, D.; Sipala, V.; Sollima, C.; Spurio, M.; Stefani, F.; Taiuti, M.; Terreni, G.; Trasatti, L.; Urso, S.; Vecchi, M.; Vicini, P.; Wischnewski, R.

    2010-03-01

    The selection of the photomultiplier plays a crucial role in the R&D activity related to a large-scale underwater neutrino telescope. This paper illustrates the main procedures and facilities used to characterize the performances of 72 large area photomultipliers, Hamamatsu model R7081 sel. The voltage to achieve a gain of 5×10 7, dark count rate and single photoelectron time and charge properties of the overall response were measured with a properly attenuated 410 nm pulsed laser. A dedicated study of the spurious pulses was also performed. The results prove that the photomultipliers comply with the general requirements imposed by the project.

  19. EUROSEISMOS 2002-2003 a project for saving and studying historical seismograms in the Eeuro-mediterranean area

    NASA Astrophysics Data System (ADS)

    Ferrari, G.; Pino, N. A.

    2003-04-01

    The study of the great earthquakes and the analysis of their tectonic significance are very important elements in the evaluation of seismic potential, seismic hazard and risk. The analysis of the seismograms of historical earthquakes plays a crucial role in understanding the patterns of deformation energy release, the characteristics of propagation and interaction of the seismic waves with the inhabited areas, in the areas affected by these events. The recovery and reproduction of historical seismograms and the indispensable information contained therein, on the instruments that recorded them and their related characteristics, often become difficult and laborious operations that deprive research of a disproportionate amount of human and economic resources in relation to the objective complexity of the matter. These difficulties have so far much reduced the number of study cases and have been a disincentive to researchers interested in dealing with this important research strand. In order to overcome these difficulties the EUROSEISMOS has been started up (http://80.117.141.2/Es_web); this is a project for collaboration between researchers and research bodies having a long tradition of seismic monitoring, with the following main objectives: 1) the recovery, with the reproduction at the SISMOS centre of the INGV, of the seismograms of the most important historical earthquakes (1895 1980) in the Euro-Mediterranean area in the 20th century; 2) benchmarking of experiences on the processing of seismographic historical data; 3) creation of a permanent workgroup on these aspects. So far 29 researchers belonging to 26 countries from Finland to Algeria, and from Georgia to Portugal, have joined the project. The approximately 300 earthquakes of primary interest for the researchers involved have been collected in a catalogue, and early in 2003 the first reproductions of seismograms were started.

  20. MORPHIN: a web tool for human disease research by projecting model organism biology onto a human integrated gene network.

    PubMed

    Hwang, Sohyun; Kim, Eiru; Yang, Sunmo; Marcotte, Edward M; Lee, Insuk

    2014-07-01

    Despite recent advances in human genetics, model organisms are indispensable for human disease research. Most human disease pathways are evolutionally conserved among other species, where they may phenocopy the human condition or be associated with seemingly unrelated phenotypes. Much of the known gene-to-phenotype association information is distributed across diverse databases, growing rapidly due to new experimental techniques. Accessible bioinformatics tools will therefore facilitate translation of discoveries from model organisms into human disease biology. Here, we present a web-based discovery tool for human disease studies, MORPHIN (model organisms projected on a human integrated gene network), which prioritizes the most relevant human diseases for a given set of model organism genes, potentially highlighting new model systems for human diseases and providing context to model organism studies. Conceptually, MORPHIN investigates human diseases by an orthology-based projection of a set of model organism genes onto a genome-scale human gene network. MORPHIN then prioritizes human diseases by relevance to the projected model organism genes using two distinct methods: a conventional overlap-based gene set enrichment analysis and a network-based measure of closeness between the query and disease gene sets capable of detecting associations undetectable by the conventional overlap-based methods. MORPHIN is freely accessible at http://www.inetbio.org/morphin.

  1. A Simplified Model of Human Alcohol Metabolism That Integrates Biotechnology and Human Health into a Mass Balance Team Project

    ERIC Educational Resources Information Center

    Yang, Allen H. J.; Dimiduk, Kathryn; Daniel, Susan

    2011-01-01

    We present a simplified human alcohol metabolism model for a mass balance team project. Students explore aspects of engineering in biotechnology: designing/modeling biological systems, testing the design/model, evaluating new conditions, and exploring cutting-edge "lab-on-a-chip" research. This project highlights chemical engineering's impact on…

  2. An aerial radiological survey of the project Rio Blanco and surrounding area

    SciTech Connect

    Singman, L.V.

    1994-11-01

    A team from the Remote Sensing Laboratory in Las Vegas, Nevada, conducted an aerial radiation survey of the area surrounding ground zero of Project Rio Blanco in the northwestern section of Colorado in June 1993. The object of the survey was to determine if there were man-made radioisotopes on or near the surface resulting from a nuclear explosion in 1972. No indications of surface contamination were found. A search for the cesium-137 radioisotope was negative. The Minimum Detectable Activity for cesium-137 is presented for several detection probabilities. The natural terrestrial exposure rates in units of Roentgens per hour were mapped and are presented in the form of a contour map over-laid on an aerial photograph. A second team made independent ground-based measurements in four places within the survey area. The average agreement of the ground-based with aerial measurements was six percent.

  3. St. Louis Area Earthquake Hazards Mapping Project - A Progress Report-November 2008

    USGS Publications Warehouse

    Karadeniz, D.; Rogers, J.D.; Williams, R.A.; Cramer, C.H.; Bauer, R.A.; Hoffman, D.; Chung, J.; Hempen, G.L.; Steckel, P.H.; Boyd, O.L.; Watkins, C.M.; McCallister, N.S.; Schweig, E.

    2009-01-01

    St. Louis has experienced minor earthquake damage at least 12 times in the past 200 years. Because of this history and its proximity to known active earthquake zones, the St. Louis Area Earthquake Hazards Mapping Project (SLAEHMP) is producing digital maps that show variability of earthquake hazards, including liquefaction and ground shaking, in the St. Louis area. The maps will be available free via the internet. Although not site specific enough to indicate the hazard at a house-by-house resolution, they can be customized by the user to show specific areas of interest, such as neighborhoods or transportation routes. Earthquakes currently cannot be predicted, but scientists can estimate how strongly the ground is likely to shake as the result of an earthquake. Earthquake hazard maps provide one way of conveying such estimates. The U.S. Geological Survey (USGS), which produces earthquake hazard maps for the Nation, is working with local partners to develop detailed maps for urban areas vulnerable to strong ground shaking. These partners, which along with the USGS comprise the SLAEHMP, include the Missouri University of Science and Technology-Rolla (Missouri S&T), Missouri Department of Natural Resources (MDNR), Illinois State Geological Survey (ISGS), Saint Louis University, Missouri State Emergency Management Agency, and URS Corporation. Preliminary hazard maps covering a test portion of the 29-quadrangle St. Louis study area have been produced and are currently being evaluated by the SLAEHMP. A USGS Fact Sheet summarizing this project was produced and almost 1000 copies have been distributed at several public outreach meetings and field trips that have featured the SLAEHMP (Williams and others, 2007). In addition, a USGS website focusing on the SLAEHMP, which provides links to project results and relevant earthquake hazard information, can be found at: http://earthquake.usgs.gov/regional/ceus/urban_map/st_louis/index.php. This progress report summarizes the

  4. Pilot project on the resettlement of out-migrant agricultural population in Yangtze Gorges Reservoir Area.

    PubMed

    Zhu, W

    1992-10-01

    A brief summary is provided of the pilot project on the resettlement of the agricultural population in Yangtze Reservoir Area, China. Population needed to be resettled from the area to be flooded by the construction of the Three Gorges Hydropower Station in the middle of the Yangtze River. The submerged area included 19 cities and counties of which 2 are county level cities, 11 county seats, 140 towns and market towns, 326 townships, and 1351 villages. The population to be evacuated totaled 725,500 residents, of whom 392,90 were urban residents and 332,600 were rural residents. The amount of cultivated land lost amounted to 3573 mu (1 mu = 17.5% of an acre). While the hydropower station is being constructed, the population will rise over 20 years to 1 million. The Chinese government has developed a program of resettlement, whereby displaced population receive financial support to develop the economy; the sum appropriated equaled 50 million yuan RMB. So far, the pilot project has been successful. Within the 326 townships affected, only part of the land lying below the highest water level of the reservoir would be affected; the remaining land could be used for resettlement, albeit the land is uncultivated grassland and barren mountains and hills. Resettlement in the area is preferred over long distance migration. The government program will help farmers make full use of the available lands. Suggested crops include mulberry trees, oranges, medical herbs, and other cash crops. Effort will be made to ensure each farmer will receive one mu of economic forest or one mu of cultivated land of high and stable yields. The program aims to guarantee sufficient food supplies and the same standard of living before displacement, as well as the opportunity to create better conditions for alleviating poverty and improvement through increased productivity.

  5. How is the Human Genome Project doing, and what have we learned so far?

    PubMed Central

    Guyer, M S; Collins, F S

    1995-01-01

    In this paper, we describe the accomplishments of the initial phase of the Human Genome Project, with particular attention to the progress made toward achieving the defined goals for constructing genetic and physical maps of the human genome and determining the sequence of human DNA, identifying the complete set of human genes, and analyzing the need for adequate policies for using the information about human genetics in ways that maximize the benefits for individuals and society. PMID:7479895

  6. Hydrologic Resources Management Program and Underground Test Area Project FY 2000 Progress Report

    SciTech Connect

    Davisson, M L; Eaton, G F; Hakemi, N L; Hudson, G B; Hutcheon, I D; Lau, C A; Kersting, A B; Kenneally, J M; Moran, J E; Phinney, D L; Rose, T P; Smith, D K; Sylwester, E R; Wang, L; Williams, R; Zavarin, M

    2001-07-01

    This report highlights the results of FY 2000 technical studies conducted by the Analytical and Nuclear Chemistry Division (ANCD) at Lawrence Livermore National Laboratory (LLNL) in support of the Hydrology and Radionuclide Migration Program (HRMP) and Underground Test Area (UGTA) Project. This is the latest in a series of annual reports published by LLNL-ANCD to document recent investigations of radionuclide migration and transport processes at the Nevada Test Site (NTS). The HRMP is sponsored by Defense Programs (DP) at the U.S. Department of Energy, Nevada Operations Office (DOENV), and supports DP operations at the NTS through studies of radiochemical and hydrologic processes that are relevant to the DP mission. Other organizations that support the HRMP include Los Alamos National Laboratory (LANL), the U.S. Geological Survey (USGS), the Desert Research Institute (DRI) of the University of Nevada, the U.S. Environmental Protection Agency (EPS), and Bechtel Nevada (BN). The UGTA Project is sponsored by the Environmental Management (EM) program at DOENV; its goal is to determine the extent of radionuclide contamination in groundwater resulting from underground nuclear testing at the NTS. The project strategy follows guidelines set forth in a Federal Facilities Agreement and Consent Order between the U.S. Department of Energy, the U.S. Department of Defense, and the State of Nevada. Participating contractors include LLNL (both ANCD and the Energy and Environmental Sciences Directorate), LANL, USGS, DRI, BN, and IT Corporation (with subcontract support from Geotrans Inc.).

  7. An Aerial Radiological Survey of the Yucca Mountain Project Proposed Land Withdrawal and Adjacent Areas

    SciTech Connect

    Craig Lyons, Thane Hendricks

    2006-07-01

    An aerial radiological survey of the Yucca Mountain Project (YMP) proposed land withdrawal was conducted from January to April 2006, and encompassed a total area of approximately 284 square miles (73,556 hectares). The aerial radiological survey was conducted to provide a sound technical basis and rigorous statistical approach for determining the potential presence of radiological contaminants in the Yucca Mountain proposed Land withdrawal area. The survey site included land areas currently managed by the Bureau of Land Management, the U.S. Air Force as part of the Nevada Test and Training Range or the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (NNSA/NSO) as part of the Nevada Test Site (NTS). The survey was flown at an approximate ground speed of 70 knots (36 meters per second), at a nominal altitude of 150 ft (46 m) above ground level, along a set of parallel flight lines spaced 250 ft (76 m) apart. The flight lines were oriented in a north-south trajectory. The survey was conducted by the DOE NNSA/NSO Remote Sensing Laboratory-Nellis, which is located in Las Vegas, Nevada. The aerial survey was conducted at the request of the DOE Office of Civilian Radioactive Waste Management. The primary contaminant of concern was identified by YMP personnel as cesium-137 ({sup 137}Cs). Due to the proposed land withdrawal area's proximity to the historical Nuclear Rocket Development Station (NRDS) facilities located on the NTS, the aerial survey system required sufficient sensitivity to discriminate between dispersed but elevated {sup 137}Cs levels from those normally encountered from worldwide fallout. As part of that process, the survey also measured and mapped the exposure-rate levels that currently existed within the survey area. The inferred aerial exposure rates of the natural terrestrial background radiation varied from less than 3 to 22 microroentgens per hour. This range of exposure rates was primarily due to the

  8. The approach of the PREFER project to wildfire prevention and damage assessment in the Mediterranean area

    NASA Astrophysics Data System (ADS)

    Laneve, Giovanni; Fusilli, Lorenzo; Tampellini, Maria Lucia; Vimercati, Marco; Hirn, Barbara; Sebastian-Lopez, Ana; Diagourtas, Dimitri; Eftychidis, Georgios; Clandillon, Stephen; Caspard, Mathilde; Oliveira, Sandra; Lourenco, Luciano

    2015-04-01

    PREFER is a Copernicus Emergency project funded from the 2012 FP7 Space Work Programme, and it is aimed at developing products and services that will contribute to improve the European capacity to respond to the preparedness, prevention, and recovery management steps in the case of forest fire emergency cycle, with focus on the Mediterranean area. It is well known from the most recent reports on state of Europe's forests that the Mediterranean area is particularly affected by uncontrolled forest fires, with a number of negative consequences on ecosystems, such as desertification and soil erosion, and on the local economy. Most likely, the current risks of forest fires will be exacerbated by climate change. In particular, the climate of Southern Europe and the Mediterranean basin is projected to warm at a rate exceeding the global average. Wild fires will therefore remain the most serious threat to Southern European forests. In this situation, the need to collect better information and more knowledge concerning future risks of forest fires and fire prevention in the Mediterranean area is widely recognized to be a major urgent one. As part of the Copernicus programme (i.e. the European Earth Observation Programme), PREFER is based on advanced geo-information products using in particular the earth observation data acquired and developed in the frame of Copernicus. The objective of the PREFER project, started at the end of 2012, 8 partners (from Italy, Portugal, Spain, France and Greece) involved and three years schedule, is the design, development and demonstration of a pre-operational "end-to-end" information service, fully exploiting satellite sensors data and able to support prevention/ preparedness and recovery phases of the Forest Fires emergency cycle in the EU Mediterranean Region. The PREFER information is as general as to be usable in the different countries of the Mediterranean Region, and acts in full complement to already existing services, such as the EC

  9. Range 8C Rehabilitation Demonstration Project, Hohenfels Training Area, Germany: Final report

    SciTech Connect

    Zellmer, S.D.; Hinchman, R.R.; Johnson, D.O. . Energy Systems Div.); Severinghaus, W.D. ); Brent, J.J. )

    1991-11-01

    More than 30 years of intensive and continual tactical training has caused extensive environmental damage at the US Army Hohenfels Training Area in Germany. The Range 8C Rehabilitation Demonstration Project, followed by a three-year monitoring effort, was conducted to develop and evaluate the environmental and economic effectiveness of seven revegetation and four erosion control prescriptions implemented at a 16-ha site. The point-intercept method was used to measure the types and amounts of vegetation established and the changes in the vegetative community during three years of military use on the seven areas treated with revegetation prescriptions. Field observations were made to determine the suitability and durability of four types of erosion control structures. Soil fertility and a source of seed appeared to be the most limiting factors in establishing vegetation, while seedbed preparation had only a minor influence. Grasses appeared to be more resistant to vehicle traffic than did other types of vegetation. Because grassed waterways were used as roads by military vehicles and a system of graded terraces was expensive, these erosion control prescriptions were unsuitable and uneconomical for use on training areas. Low-cost riprap waterbars and porous check dams slowed the velocity of runoff, trapped sediments, and were durable. Recommendations were formulated to improve the environmental and economic effectiveness of future rehabilitation efforts on tactical training areas.

  10. Assessing corporate project impacts in changeable contexts: A human rights perspective

    SciTech Connect

    Salcito, Kendyl; Singer, Burton H.; Krieger, Gary R.; Weiss, Mitchell G.; Wielga, Mark; Utzinger, Jürg

    2014-07-01

    Project-level impact assessment was originally conceived as a snapshot taken in advance of project implementation, contrasting current conditions with a likely future scenario involving a variety of predicted impacts. Current best practice guidance has encouraged a shift towards longitudinal assessments from the pre-project stage through the implementation and operating phases. Experience and study show, however, that assessment of infrastructure-intensive projects rarely endures past the project's construction phase. Negative consequences for environmental, social and health outcomes have been documented. Such consequences clarify the pressing need for longitudinal assessment in each of these domains, with human rights impact assessment (HRIA) as an umbrella over, and critical augmentation of, environmental, social and health assessments. Project impacts on human rights are more closely linked to political, economic and other factors beyond immediate effects of a company's policy and action throughout the project lifecycle. Delineating these processes requires an adequate framework, with strategies for collecting longitudinal data, protocols that provide core information for impact assessment and guidance for adaptive mitigation strategies as project-related effects change over time. This article presents general principles for the design and implementation of sustained, longitudinal HRIA, based on experience assessing and responding to human rights impact in a uranium mining project in Malawi. The case study demonstrates the value of longitudinal assessment both for limiting corporate risk and improving human welfare. - Graphical abstract: Assessing changes in human rights condition as affected by both project and context, over time. - Highlights: • Corporate capital projects affect human rights in myriad ways. • Ongoing, longitudinal impact assessment techniques are needed. • We present an approach for conducting longitudinal human rights impact assessment

  11. Natural resource dependency and decentralized conservation within Kanchenjunga Conservation Area Project, Nepal.

    PubMed

    Parker, Pete; Thapa, Brijesh

    2012-02-01

    Kanchenjunga Conservation Area Project (KCAP) in Nepal is among the first protected areas in the world to institute a completely decentralized system of conservation and development. Proponents of decentralized conservation claim that it increases management efficiency, enhances the responsiveness to local needs, and promotes greater equity among local residents. This study assessed local equity by evaluating the levels of dependencies on natural resources among households and the factors affecting that dependency. Data were collected via detailed surveys among 205 randomly selected households within the KCAP. Natural resource dependency was evaluated by comparing the ratio of total household income to income derived from access to natural resources. Economic, social, and access-related variables were employed to determine potential significant predictors of dependency. Overall, households were heavily dependent on natural resources for their income, especially households at higher elevations and those with more adult members. The households that received remittances were most able to supplement their income and, therefore, drastically reduced their reliance on the access to natural resources. Socio-economic variables, such as land holdings, education, caste, and ethnicity, failed to predict dependency. Household participation in KCAP-sponsored training programs also failed to affect household dependency; however, fewer than 20% of the households had any form of direct contact with KCAP personnel within the past year. The success of the KCAP as a decentralized conservation program is contingent on project capacity-building via social mobilization, training programs, and participatory inclusion in decision making to help alleviate the dependency on natural resources.

  12. Natural Resource Dependency and Decentralized Conservation Within Kanchenjunga Conservation Area Project, Nepal

    NASA Astrophysics Data System (ADS)

    Parker, Pete; Thapa, Brijesh

    2012-02-01

    Kanchenjunga Conservation Area Project (KCAP) in Nepal is among the first protected areas in the world to institute a completely decentralized system of conservation and development. Proponents of decentralized conservation claim that it increases management efficiency, enhances the responsiveness to local needs, and promotes greater equity among local residents. This study assessed local equity by evaluating the levels of dependencies on natural resources among households and the factors affecting that dependency. Data were collected via detailed surveys among 205 randomly selected households within the KCAP. Natural resource dependency was evaluated by comparing the ratio of total household income to income derived from access to natural resources. Economic, social, and access-related variables were employed to determine potential significant predictors of dependency. Overall, households were heavily dependent on natural resources for their income, especially households at higher elevations and those with more adult members. The households that received remittances were most able to supplement their income and, therefore, drastically reduced their reliance on the access to natural resources. Socio-economic variables, such as land holdings, education, caste, and ethnicity, failed to predict dependency. Household participation in KCAP-sponsored training programs also failed to affect household dependency; however, fewer than 20% of the households had any form of direct contact with KCAP personnel within the past year. The success of the KCAP as a decentralized conservation program is contingent on project capacity-building via social mobilization, training programs, and participatory inclusion in decision making to help alleviate the dependency on natural resources.

  13. Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Regulate Feeding and Reward

    PubMed Central

    Stamatakis, Alice M.; Van Swieten, Maaike; Basiri, Marcus L.; Blair, Grace A.; Kantak, Pranish

    2016-01-01

    The overconsumption of calorically dense, highly palatable foods is thought to be a major contributor to the worldwide obesity epidemic; however, the precise neural circuits that directly regulate hedonic feeding remain elusive. Here, we show that lateral hypothalamic area (LHA) glutamatergic neurons, and their projections to the lateral habenula (LHb), negatively regulate the consumption of palatable food. Genetic ablation of LHA glutamatergic neurons increased daily caloric intake and produced weight gain in mice that had access to a high-fat diet, while not altering general locomotor activity. Anterior LHA glutamatergic neurons send a functional glutamatergic projection to the LHb, a brain region involved in processing aversive stimuli and negative reward prediction outcomes. Pathway-specific, optogenetic stimulation of glutamatergic LHA-LHb circuit resulted in detectable glutamate-mediated EPSCs as well as GABA-mediated IPSCs, although the net effect of neurotransmitter release was to increase the firing of most LHb neurons. In vivo optogenetic inhibition of LHA-LHb glutamatergic fibers produced a real-time place preference, whereas optogenetic stimulation of LHA-LHb glutamatergic fibers had the opposite effect. Furthermore, optogenetic inhibition of LHA-LHb glutamatergic fibers acutely increased the consumption of a palatable liquid caloric reward. Collectively, these results demonstrate that LHA glutamatergic neurons are well situated to bidirectionally regulate feeding and potentially other behavioral states via their functional circuit connectivity with the LHb and potentially other brain regions. SIGNIFICANCE STATEMENT In this study, we show that the genetic ablation of LHA glutamatergic neurons enhances caloric intake. Some of these LHA glutamatergic neurons project to the lateral habenula, a brain area important for generating behavioral avoidance. Optogenetic stimulation of this circuit has net excitatory effects on postsynaptic LHb neurons. This is the

  14. Streamlined approach for environmental restoration plan for corrective action unit 416, Mud Pit, Project Shoal Area

    SciTech Connect

    1997-07-01

    This plan addresses the actions necessary for the restoration and closure of the Project Shoal Area (PSA), Surface Corrective Action Unit (CAU) 416, Mud Pit (Corrective Action Site No. 57-09-01), a pit that was used to store effluent produced during drilling of the Post-Shot Borehole PS-1 in 1963. This plan describes the activities that will occur at the site and the steps that will be taken to gather enough data to obtain a notice of completion from the Nevada Division of Environmental Protection (NDEP). This plan was prepared under the Streamlined Approach for Environmental Restoration (SAFER) concept, and it will be implemented with the Federal Facility Agreement and Consent Order (FFACO) (FFACO, 1996) and the Industrial Sites Quality Assurance Project Plan (DOE/NV, 1994). The SAFER process is being employed at this CAU where enough information exists about the nature and extent of contamination to propose an appropriate corrective action without completing a Corrective Action Decision Document and Corrective Action Plan. This process combines elements of the Data Quality Objective (DQO) process and the observational approach to help plan and conduct corrective actions. DQOs are used to identify the problem and define the type and quality of data needed to complete the investigation phase of the process. This has already been completed for the mud pit so it will not be repeated here. The DQOs for the mud pit are presented in the Corrective Action Investigation Plan for Project Shoal Area, CAU No. 416 (DOE/NV, 1996). This observational approach provides a framework for managing uncertainty and planning decision making.

  15. E-Area Vault Concrete Material Property And Vault Durability/Degradation Projection Recommendations

    SciTech Connect

    Phifer, M. A.

    2014-03-11

    Subsequent to the 2008 E-Area Low-Level Waste Facility (ELLWF) Performance Assessment (PA) (WSRC 2008), two additional E-Area vault concrete property testing programs have been conducted (Dixon and Phifer 2010 and SIMCO 2011a) and two additional E-Area vault concrete durability modeling projections have been made (Langton 2009 and SIMCO 2012). All the information/data from these reports has been evaluated and consolidated herein by the Savannah River National Laboratory (SRNL) at the request of Solid Waste Management (SWM) to produce E-Area vault concrete hydraulic and physical property data and vault durability/degradation projection recommendations that are adequately justified for use within associated Special Analyses (SAs) and future PA updates. The Low Activity Waste (LAW) and Intermediate Level (IL) Vaults structural degradation predictions produced by Carey 2006 and Peregoy 2006, respectively, which were used as the basis for the 2008 ELLWF PA, remain valid based upon the results of the E-Area vault concrete durability simulations reported by Langton 2009 and those reported by SIMCO 2012. Therefore revised structural degradation predictions are not required so long as the mean thickness of the closure cap overlying the vaults is no greater than that assumed within Carey 2006 and Peregoy 2006. For the LAW Vault structural degradation prediction (Carey 2006), the mean thickness of the overlying closure cap was taken as nine feet. For the IL Vault structural degradation prediction (Peregoy 2006), the mean thickness of the overlying closure cap was taken as eight feet. The mean closure cap thicknesses as described here for both E-Area Vaults will be included as a key input and assumption (I&A) in the next revision to the closure plan for the ELLWF (Phifer et al. 2009). In addition, it has been identified as new input to the PA model to be assessed in the ongoing update to the new PA Information UDQE (Flach 2013). Once the UDQE is approved, the SWM Key I

  16. Suitable Days for Plant Growth Disappear under Projected Climate Change: Potential Human and Biotic Vulnerability

    PubMed Central

    Mora, Camilo; Caldwell, Iain R.; Caldwell, Jamie M.; Fisher, Micah R.; Genco, Brandon M.; Running, Steven W.

    2015-01-01

    Ongoing climate change can alter conditions for plant growth, in turn affecting ecological and social systems. While there have been considerable advances in understanding the physical aspects of climate change, comprehensive analyses integrating climate, biological, and social sciences are less common. Here we use climate projections under alternative mitigation scenarios to show how changes in environmental variables that limit plant growth could impact ecosystems and people. We show that although the global mean number of days above freezing will increase by up to 7% by 2100 under “business as usual” (representative concentration pathway [RCP] 8.5), suitable growing days will actually decrease globally by up to 11% when other climatic variables that limit plant growth are considered (i.e., temperature, water availability, and solar radiation). Areas in Russia, China, and Canada are projected to gain suitable plant growing days, but the rest of the world will experience losses. Notably, tropical areas could lose up to 200 suitable plant growing days per year. These changes will impact most of the world’s terrestrial ecosystems, potentially triggering climate feedbacks. Human populations will also be affected, with up to ~2,100 million of the poorest people in the world (~30% of the world’s population) highly vulnerable to changes in the supply of plant-related goods and services. These impacts will be spatially variable, indicating regions where adaptations will be necessary. Changes in suitable plant growing days are projected to be less severe under strong and moderate mitigation scenarios (i.e., RCP 2.6 and RCP 4.5), underscoring the importance of reducing emissions to avoid such disproportionate impacts on ecosystems and people. PMID:26061091

  17. Suitable Days for Plant Growth Disappear under Projected Climate Change: Potential Human and Biotic Vulnerability.

    PubMed

    Mora, Camilo; Caldwell, Iain R; Caldwell, Jamie M; Fisher, Micah R; Genco, Brandon M; Running, Steven W

    2015-06-01

    Ongoing climate change can alter conditions for plant growth, in turn affecting ecological and social systems. While there have been considerable advances in understanding the physical aspects of climate change, comprehensive analyses integrating climate, biological, and social sciences are less common. Here we use climate projections under alternative mitigation scenarios to show how changes in environmental variables that limit plant growth could impact ecosystems and people. We show that although the global mean number of days above freezing will increase by up to 7% by 2100 under "business as usual" (representative concentration pathway [RCP] 8.5), suitable growing days will actually decrease globally by up to 11% when other climatic variables that limit plant growth are considered (i.e., temperature, water availability, and solar radiation). Areas in Russia, China, and Canada are projected to gain suitable plant growing days, but the rest of the world will experience losses. Notably, tropical areas could lose up to 200 suitable plant growing days per year. These changes will impact most of the world's terrestrial ecosystems, potentially triggering climate feedbacks. Human populations will also be affected, with up to ~2,100 million of the poorest people in the world (~30% of the world's population) highly vulnerable to changes in the supply of plant-related goods and services. These impacts will be spatially variable, indicating regions where adaptations will be necessary. Changes in suitable plant growing days are projected to be less severe under strong and moderate mitigation scenarios (i.e., RCP 2.6 and RCP 4.5), underscoring the importance of reducing emissions to avoid such disproportionate impacts on ecosystems and people.

  18. 33 CFR 165.T01-1130 - Regulated Navigation Area; S99 Alford Street Bridge rehabilitation project, Mystic River, MA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Alford Street Bridge rehabilitation project, Mystic River, MA. 165.T01-1130 Section 165.T01-1130... Street Bridge rehabilitation project, Mystic River, MA. (a) Location. The following area is a Regulated... to bottom, within 100 yards of any point on the S99 Alford Street Bridge. (b) Regulations. (1)...

  19. Outcomes from the USDA/ARS area-wide project for management of the Asian tiger mosquito, Aedes albopictus

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Asian tiger mosquito, Aedes albopictus, became established in the continental US in 1985 and now infests 30 states. In 2007 the USDA Agricultural Research Service funded an “area-wide” project focused on the management of this species. The project was a unique federal, state, local collaborati...

  20. Using Big Data to Understand the Human Condition: The Kavli HUMAN Project

    PubMed Central

    Azmak, Okan; Bayer, Hannah; Caplin, Andrew; Chun, Miyoung; Glimcher, Paul; Koonin, Steven; Patrinos, Aristides

    2015-01-01

    Abstract Until now, most large-scale studies of humans have either focused on very specific domains of inquiry or have relied on between-subjects approaches. While these previous studies have been invaluable for revealing important biological factors in cardiac health or social factors in retirement choices, no single repository contains anything like a complete record of the health, education, genetics, environmental, and lifestyle profiles of a large group of individuals at the within-subject level. This seems critical today because emerging evidence about the dynamic interplay between biology, behavior, and the environment point to a pressing need for just the kind of large-scale, long-term synoptic dataset that does not yet exist at the within-subject level. At the same time that the need for such a dataset is becoming clear, there is also growing evidence that just such a synoptic dataset may now be obtainable—at least at moderate scale—using contemporary big data approaches. To this end, we introduce the Kavli HUMAN Project (KHP), an effort to aggregate data from 2,500 New York City households in all five boroughs (roughly 10,000 individuals) whose biology and behavior will be measured using an unprecedented array of modalities over 20 years. It will also richly measure environmental conditions and events that KHP members experience using a geographic information system database of unparalleled scale, currently under construction in New York. In this manner, KHP will offer both synoptic and granular views of how human health and behavior coevolve over the life cycle and why they evolve differently for different people. In turn, we argue that this will allow for new discovery-based scientific approaches, rooted in big data analytics, to improving the health and quality of human life, particularly in urban contexts. PMID:26487987

  1. Using Big Data to Understand the Human Condition: The Kavli HUMAN Project.

    PubMed

    Azmak, Okan; Bayer, Hannah; Caplin, Andrew; Chun, Miyoung; Glimcher, Paul; Koonin, Steven; Patrinos, Aristides

    2015-09-01

    Until now, most large-scale studies of humans have either focused on very specific domains of inquiry or have relied on between-subjects approaches. While these previous studies have been invaluable for revealing important biological factors in cardiac health or social factors in retirement choices, no single repository contains anything like a complete record of the health, education, genetics, environmental, and lifestyle profiles of a large group of individuals at the within-subject level. This seems critical today because emerging evidence about the dynamic interplay between biology, behavior, and the environment point to a pressing need for just the kind of large-scale, long-term synoptic dataset that does not yet exist at the within-subject level. At the same time that the need for such a dataset is becoming clear, there is also growing evidence that just such a synoptic dataset may now be obtainable-at least at moderate scale-using contemporary big data approaches. To this end, we introduce the Kavli HUMAN Project (KHP), an effort to aggregate data from 2,500 New York City households in all five boroughs (roughly 10,000 individuals) whose biology and behavior will be measured using an unprecedented array of modalities over 20 years. It will also richly measure environmental conditions and events that KHP members experience using a geographic information system database of unparalleled scale, currently under construction in New York. In this manner, KHP will offer both synoptic and granular views of how human health and behavior coevolve over the life cycle and why they evolve differently for different people. In turn, we argue that this will allow for new discovery-based scientific approaches, rooted in big data analytics, to improving the health and quality of human life, particularly in urban contexts.

  2. Buffalo Metropolitan Area, New York Water Resources Management. Detailed Project Report for Flood Management in Cayuga Creek Watershed.

    DTIC Science & Technology

    1979-08-01

    plan is acceptable if it is, or will likely be, supported by a significant segment of the public. However, every attempt should be made to eliminate...protection from overbank flooding in the area. The level was chosen as the most likely to provide the greatest protection and be economically justified...and small mammals and reptiles . Again, no new development in the project area is expected to take place after project construction and the recommended

  3. Application of the Sketch Match method in Sulina coastal study area within PEGASO project

    NASA Astrophysics Data System (ADS)

    Marin, Eugenia; Nichersu, Iuliana; Mierla, Marian; Trifanov, Cristian; Nichersu, Iulian

    2013-04-01

    The Sketch Match approach for Sulina pilot case was carried out in the frame of the project "People for Ecosystem Based Governance in Assessing Sustainable Development of Ocean and Coast" - PEGASO, funded by the Seventh Framework Programme. The PEGASO project has been designed to identify common threats and solutions in relation to the long-term sustainable development and environmental protection of coastal zones bordering the Mediterranean and Black Seas in ways relevant to the implementation of the Integrated Coastal Zone Management Protocol (ICZM) for the Mediterranean. PEGASO will use the model of the existing ICZM Protocol for the Mediterranean and adjust it to the needs of the Black Sea through innovative actions, one of them being Refine and develop efficient and easy to use tools for making sustainability assessments in the coastal zone tested through a number of relevant pilot sites. Thus, for the Romania case study, the Sketch Match approach was selected, being an interactive public participation planning method, developed by the Dutch Government, and applied for Sulina area in order to stimulate support and involvement from stakeholders regarding Integrated Coastal Zone Management Protocol by consulting and involving these people in the planning process and making use of a coherent package of interactive methods. Participants were representatives of a wide range of stakeholders, varying from local fisherman to representatives of the Local and County council and Danube Delta Biosphere Reserve Authority. They participated in a two-day design session, focused on problems and potentials of the area, with the aim to work out possible solutions for an integrated coastal spatial planning, focusing on the parallel enhance of the various local functions in the spatial design (coastal area protection next to industry, tourism, nature, recreation, and other activities).

  4. Proposed Project Selection Method for Human Support Research and Technology Development (HSR&TD)

    NASA Technical Reports Server (NTRS)

    Jones, Harry

    2005-01-01

    The purpose of HSR&TD is to deliver human support technologies to the Exploration Systems Mission Directorate (ESMD) that will be selected for future missions. This requires identifying promising candidate technologies and advancing them in technology readiness until they are acceptable. HSR&TD must select an may of technology development projects, guide them, and either terminate or continue them, so as to maximize the resulting number of usable advanced human support technologies. This paper proposes an effective project scoring methodology to support managing the HSR&TD project portfolio. Researchers strongly disagree as to what are the best technology project selection methods, or even if there are any proven ones. Technology development is risky and outstanding achievements are rare and unpredictable. There is no simple formula for success. Organizations that are satisfied with their project selection approach typically use a mix of financial, strategic, and scoring methods in an open, established, explicit, formal process. This approach helps to build consensus and develop management insight. It encourages better project proposals by clarifying the desired project attributes. We propose a project scoring technique based on a method previously used in a federal laboratory and supported by recent research. Projects are ranked by their perceived relevance, risk, and return - a new 3 R's. Relevance is the degree to which the project objective supports the HSR&TD goal of developing usable advanced human support technologies. Risk is the estimated probability that the project will achieve its specific objective. Return is the reduction in mission life cycle cost obtained if the project is successful. If the project objective technology performs a new function with no current cost, its return is the estimated cash value of performing the new function. The proposed project selection scoring method includes definitions of the criteria, a project evaluation

  5. Human body area factors for radiation exchange analysis: standing and walking postures.

    PubMed

    Park, Sookuk; Tuller, Stanton E

    2011-09-01

    Effective radiation area factors (f (eff)) and projected area factors (f (p)) of unclothed Caucasians' standing and walking postures used in estimating human radiation exchange with the surrounding environment were determined from a sample of adults in Canada. Several three-dimensional (3D) computer body models were created for standing and walking postures. Only small differences in f (eff) and f (p) values for standing posture were found between gender (male or female) and body type (normal- or over-weight). Differences between this study and previous studies were much larger: ≤0.173 in f (p) and ≤0.101 in f (eff). Directionless f (p) values for walking posture also had only minor differences between genders and positions in a stride. However, the differences of mean directional f (p) values of the positions dependent on azimuth angles were large enough, ≤0.072, to create important differences in modeled radiation receipt. Differences in f (eff) values were small: 0.02 between the normal-weight male and female models and up to 0.033 between positions in a stride. Variations of directional f (p) values depending on solar altitudes for walking posture were narrower than those for standing posture. When both standing and walking postures are considered, the mean f (eff) value, 0.836, of standing (0.826) and walking (0.846) could be used. However, f (p) values should be selected carefully because differences between directional and directionless f (p) values were large enough that they could influence the estimated level of human thermal sensation.

  6. Electrophysiological and functional connectivity of the human supplementary motor area.

    PubMed

    Narayana, Shalini; Laird, Angela R; Tandon, Nitin; Franklin, Crystal; Lancaster, Jack L; Fox, Peter T

    2012-08-01

    Neuro-imaging methods for detecting functional and structural inter-regional connectivity are in a rapid phase of development. While reports of regional connectivity patterns based on individual methods are becoming common, studies comparing the results of two or more connectivity-mapping methods remain rare. In this study, we applied transcranial magnetic stimulation during PET imaging (TMS/PET), a stimulation-based method, and meta-analytic connectivity modeling (MACM), a task-based method to map the connectivity patterns of the supplementary motor area (SMA). Further, we drew upon the behavioral domain meta-data of the BrainMap® database to characterize the behavioral domain specificity of two maps. Both MACM and TMS/PET detected multi-synaptic connectivity patterns, with the MACM-detected connections being more extensive. Both MACM and TMS/PET detected connections belonging to multiple behavioral domains, including action, cognition and perception. Finally, we show that the two connectivity-mapping methods are complementary in that, the MACM informed on the functional nature of SMA connections, while TMS/PET identified brain areas electrophysiologically connected with the SMA. Thus, we demonstrate that integrating multimodal database and imaging techniques can derive comprehensive connectivity maps of brain areas.

  7. Ground-water investigations of the Project Gnome area, Eddy and Lea Counties, New Mexico

    USGS Publications Warehouse

    Cooper, J.B.

    1962-01-01

    The U.S. Atomic Energy Commission, through the Office of Test Operations, Albuquerque Operations Office, plans to detonate a nuclear device in a massive salt bed 1,200 feet beneath the land surface. The project, known as Project Gnome, is an element of the Plowshare program--a study of peacetime applications of nuclear fission. The location of the proposed underground shot is in a sparsely-populated area in southeastern Eddy County, N. Mex., east of the Pecos River and about 25 miles southeast of the city of Carlsbad. The area is arid to Semiarid and ground water is a vital factor in the economic utilization of the land, which is primarily used for stock raising. An investigation of the Project Gnome site and surrounding area for the purposes of evaluating the ground-water resources and the possible effect upon them from the detonation of the nuclear shot was desired by the Commission. This report describes work done by the U.S. Geological Survey on behalf of the Commission and presents results of the investigation of the ground-water resources and geology of the area. The most intensive investigations were made within a 15-mile radius of the site of Project Gnome and mainly on the east side of the Pecos River. The total area of study of over 1,200 square miles includes parts of Eddy and Lea Counties, N. Mex. The Project Gnome site is in the sedimentary Delaware Basin. It is underlain by about 18,000 feet of sedimentary rocks ranging in age from Ordovician to Recent. Upper Permian evaporitic rocks, which contain the principal source of potash available in the United States, are worked in nearby mines. The potash minerals are found in a massive salt bed about 1,400 feet thick in the Salado Formation of Permian age. The land surface of the area is covered mostly by a wind-blown sand and caliche; however, rocks of the Rustler Formation of Permian age and younger rocks of Permian, Triassic, Pleistocene(?) and Recent age crop out at several localities. Solution by

  8. Polybrominated diphenyl ethers in soils, sediments, and human hair in a plastic waste recycling area: a neglected heavily polluted area.

    PubMed

    Tang, Zhenwu; Huang, Qifei; Cheng, Jiali; Yang, Yufei; Yang, Jun; Guo, Wei; Nie, Zhiqiang; Zeng, Ning; Jin, Lu

    2014-01-01

    The release of pollutants during the recycling of contaminated plastics is a problem which has drawn worldwide attention; however, little information on the transfer of polybrominated diphenyl ethers (PBDEs) in these processes is available. We conducted a survey of PBDEs in soils, sediments, and human hair in a typical plastic waste recycling area in northern China. The total concentrations (ng/g) of 21 PBDEs were 1.25-5504 (average 600), 18.2-9889 (average 1619), and 1.50-861 (average 112) in soils, sediments, and hair, respectively. The PBDE concentrations were comparable to concentrations observed in e-waste recycling areas; however, the concentrations in soils and sediments were 1-3 orders of magnitude higher than in other areas, and the concentrations in hair were much higher than in other areas. This indicates that this area is highly polluted with PBDEs. BDE-209 was the dominant congener (representing 91.23%, 92.3%, and 91.5% of the total PBDEs observed in soils, sediments, and hair, respectively), indicating that the commercial deca-BDE product was dominant. The commercial penta- and octa-BDE products made small contributions to the total PBDE concentrations, unlike what has been found in some e-waste recycling areas. Our results show that crude plastic waste processing is a major contributor of PBDEs to the environment and humans, which should be of great concern.

  9. Hydrologic Resources Management Program and Underground Test Area Project FY2005 Progress Report

    SciTech Connect

    Eaton, G F; Genetti, V; Hu, Q; Hudson, G B; Kersting, A B; Lindvall, R E; Moran, J E; Nimz, G J; Ramon, E C; Rose, T P; Shuller, L; Williams, R W; Zavarin, M; Zhao, P

    2007-03-23

    This report describes FY 2005 technical studies conducted by the Chemical Biology and Nuclear Science Division (CBND) at Lawrence Livermore National Laboratory (LLNL) in support of the Hydrologic Resources Management Program (HRMP) and the Underground Test Area Project (UGTA). These programs are administered by the U.S. Department of Energy, National Nuclear Security Administration, Nevada Site Office (NNSA/NSO) through the Defense Programs and Environmental Restoration Divisions, respectively. HRMP-sponsored work is directed toward the responsible management of the natural resources at the Nevada Test Site (NTS), enabling its continued use as a staging area for strategic operations in support of national security. UGTA-funded work emphasizes the development of an integrated set of groundwater flow and contaminant transport models to predict the extent of radionuclide migration from underground nuclear testing areas at the NTS. The report is organized on a topical basis and contains five chapters that highlight technical work products produced by CBND. However, it is important to recognize that most of this work involves collaborative partnerships with the other HRMP and UGTA contract organizations. These groups include the Energy and Environment Directorate at LLNL (LLNL-E&E), Los Alamos National Laboratory (LANL), the Desert Research Institute (DRI), the U.S. Geological Survey (USGS), Stoller-Navarro Joint Venture (SNJV), and Bechtel Nevada (BN).

  10. Salt Lake City Area Integrated Projects Electric Power Marketing. Draft environmental impact statement: Volume 1, Summary

    SciTech Connect

    Not Available

    1994-02-01

    The Salt Lake City Area Office of the Western Area Power Administration (Western) markets electricity produced at hydroelectric facilities operated by the Bureau of Reclamation. The facilities are known collectively as the Salt Lake City Area Integrated Projects (SLCA/IP) and include dams equipped for power generation on the Green, Gunnison, Rio Grande, and Colorado rivers and on Deer and Plateau creeks in the states of Wyoming, Utah, Colorado, Arizona, and New Mexico. Of these facilities, only the Glen Canyon Unit, the Flaming Gorge Unit, and the Aspinall Unit (which includes Blue Mesa, Morrow Point, and Crystal dams) are influenced by Western`s power scheduling and transmission decisions. The EIS alternatives, called commitment-level alternatives, reflect combinations of capacity and energy that would feasibly and reasonably fulfill Western`s firm power marketing responsibilities, needs, and statutory obligations. The viability of these alternatives relates directly to the combination of generation capability of the SLCA/IP with energy purchases and interchange. The economic and natural resource assessments in this environmental impact statement (EIS) include an analysis of commitment-level alternatives. Impacts of the no-action altemative are also assessed. Supply options, which include combinations of electrical power purchases and hydropower operational scenarios reflecting different operations of the dams, are also assessed. The EIS evaluates the impacts of these scenarios relative to socioeconomics, air resources, water resources, ecological resources, cultural resources, land use, recreation, and visual resources.

  11. New Approach for forest inventory estimation and timber harvesting planning in mountain areas: the SLOPE project

    NASA Astrophysics Data System (ADS)

    Prandi, F.; Magliocchetti, D.; Poveda, A.; De Amicis, R.; Andreolli, M.; Devigili, F.

    2016-06-01

    Forests represent an important economic resource for mountainous areas being for a few region and mountain communities the main form of income. However, wood chain management in these contexts differs from the traditional schemes due to the limits imposed by terrain morphology, both for the operation planning aspects and the hardware requirements. In fact, forest organizational and technical problems require a wider strategic and detailed level of planning to reach the level of productivity of forest operation techniques applied on flatlands. In particular, a perfect knowledge of forest inventories improves long-term management sustainability and efficiency allowing a better understanding of forest ecosystems. However, this knowledge is usually based on historical parcel information with only few cases of remote sensing information from satellite imageries. This is not enough to fully exploit the benefit of the mountain areas forest stocks where the economic and ecological value of each single parcel depends on singletree characteristics. The work presented in this paper, based on the results of the SLOPE (Integrated proceSsing and controL systems fOr sustainable forest Production in mountain arEas) project, investigates the capability to generate, manage and visualize detailed virtual forest models using geospatial information, combining data acquired from traditional on-the-field laser scanning surveys technologies with new aerial survey through UAV systems. These models are then combined with interactive 3D virtual globes for continuous assessment of resource characteristics, harvesting planning and real-time monitoring of the whole production.

  12. Hydrologic Resources Management Program and Underground Tests Area Project FY 2003 Progress Report

    SciTech Connect

    J., B C; F., E G; K., E B; L., F D; J., H L; Max, H; Bryant, H G; B., K A; E., M J; A., P G; P., R T; K., S D; F.B., T A; W., W R; Mavrik, Z; Pihong, Z

    2004-08-17

    This report describes FY 2003 technical studies conducted by the Chemical Biology and Nuclear Science Division (CBND) at Lawrence Livermore National Laboratory (LLNL) in support of the Hydrologic Resources Management Program (HRMP) and the Underground Test Area (UGTA) Project. These programs are administered by the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) through the Defense Programs and Environmental Restoration Divisions, respectively. HRMP-sponsored work is directed toward the responsible management of the natural resources at the Nevada Test Site (NTS), enabling its continued use as a staging area for strategic operations in support of national security. UGTA-funded work emphasizes the development of an integrated set of groundwater flow and contaminant transport models to predict the extent of radionuclide migration from underground nuclear testing areas at the NTS. The present report is organized on a topical basis and contains five chapters that reflect the range of technical work performed by LLNL-CBND during FY 2003. Although we have emphasized investigations that were led by CBND, we also participated in a variety of collaborative studies with other UGTA and HRMP contract organizations including the Energy and Environment Directorate at LLNL (LLNL-E&E), Los Alamos National Laboratory (LANL), the Desert Research Institute (DRI), the U.S. Geological Survey (USGS), Stoller-Navarro Joint Venture (SNJV), and Bechtel Nevada (BN).

  13. Development of a Groundwater Management Model for the Project Shoal Area

    SciTech Connect

    G. Lamorey; S. Bassett; R. Schumer; D. Boyle; G. Pohll; J. Chapman

    2006-09-01

    This document describes the development of a user-friendly and efficient groundwater management model of the Project Shoal Area (PSA and surrounding area that will allow the U.S. Department of Energy and State of Nevada personnel to evaluate the impact of proposed water-use scenarios. The management model consists of a simple hydrologic model within an interactive groundwater management framework. This framework is based on an object user interface that was developed by the U.S. Geological Survey and has been used by the Desert Research Institute researchers and others to couple disparate environmental resource models, manage temporal and spatial data, and evaluate model results for management decision making. This framework was modified and applied to the PSA and surrounding Fairview Basin. The utility of the management model was demonstrated through the application of hypothetical future scenarios including mineral mining, regional expansion of agriculture, and export of water to large urban areas outside the region. While the results from some of the scenarios indicated potential impacts to groundwater levels near the PSA and others did not, together they demonstrate the utility of the management tool for the evaluation of proposed changes in groundwater use in or near the PSA.

  14. Human support issues and systems for the space exploration initiative: Results from Project Outreach

    NASA Technical Reports Server (NTRS)

    Aroesty, J.; Zimmerman, R.; Logan, J.

    1991-01-01

    The analyses and evaluations of the Human Support panel are discussed. The Human Support panel is one of eight panels created by RAND to screen and analyze submissions to the Space Exploration Initiative (SEI) Outreach Program. Submissions to the Human Support panel were in the following areas: radiation protection; microgravity; life support systems; medical care; and human factors (behavior and performance).

  15. March 10, 2006, Transportation Conformity Rule That Addresses Requirements for Project-level Conformity Determinations in PM2.5 and PM10 Nonattainment and Maintenance Areas

    EPA Pesticide Factsheets

    This final rule, published March 10, 2006, establishes requirements for project-level conformity determinations in particulate matter (PM) 2.5 nonattainment and maintenance areas, and revises existing requirements for projects in PM10 areas.

  16. Human Engineering Modeling and Performance Lab Study Project

    NASA Technical Reports Server (NTRS)

    Oliva-Buisson, Yvette J.

    2014-01-01

    The HEMAP (Human Engineering Modeling and Performance) Lab is a joint effort between the Industrial and Human Engineering group and the KAVE (Kennedy Advanced Visualiations Environment) group. The lab consists of sixteen camera system that is used to capture human motions and operational tasks, through te use of a Velcro suit equipped with sensors, and then simulate these tasks in an ergonomic software package know as Jac, The Jack software is able to identify the potential risk hazards.

  17. 78 FR 8192 - Agency Information Collection Activities: Comment Request; Education and Human Resources Project...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-05

    ... From the Federal Register Online via the Government Publishing Office NATIONAL SCIENCE FOUNDATION Agency Information Collection Activities: Comment Request; Education and Human Resources Project... study will assess the implementation of resources, models, and technologies to determine how and...

  18. MANAGEMENT OF TRANSURANIC (TRU) WASTE RETRIEVAL PROJECT RISKS SUCCESSES IN THE STARTUP OF THE HANFORD 200 AREA TRU WASTE RETRIEVAL PROJECT

    SciTech Connect

    GREENWLL, R.D.

    2005-01-20

    A risk identification and mitigation method applied to the Transuranic (TRU) Waste Retrieval Project performed at the Hanford 200 Area burial grounds is described. Retrieval operations are analyzed using process flow diagramming. and the anticipated project contingencies are included in the Authorization Basis and operational plans. Examples of uncertainties assessed include degraded container integrity, bulged drums, unknown containers, and releases to the environment. Identification and mitigation of project risks contributed to the safe retrieval of over 1700 cubic meters of waste without significant work stoppage and below the targeted cost per cubic meter retrieved. This paper will be of interest to managers, project engineers, regulators, and others who are responsible for successful performance of waste retrieval and other projects with high safety and performance risks.

  19. 2008 Groundwater Monitoring Report Project Shoal Area, Corrective Action Unit 447

    SciTech Connect

    2009-03-01

    This report presents the 2008 groundwater monitoring results collected by the U.S. Department of Energy (DOE) Office of Legacy Management (LM) at the Project Shoal Area (PSA) Subsurface Corrective Action Unit (CAU) 447 located in Churchill County, Nevada. Responsibility for the environmental site restoration of the PSA was transferred from the DOE Office of Environmental Management to LM on October 1, 2006. The environmental restoration process and corrective action strategy for CAU 447 are conducted in accordance with the Federal Facility Agreement and Consent Order (FFACO 1996, as amended February 2008) entered into by DOE, the U.S. Department of Defense, and the State of Nevada. The corrective action strategy for the site includes proof of concept monitoring in support of site closure. This report summarizes investigation activities associated with CAU 447 that were conducted at the site during 2008. This is the second groundwater monitoring report prepared by LM for the PSA

  20. 2010 Groundwater Monitoring Report Project Shoal Area, Corrective Action Unit 447

    SciTech Connect

    2011-02-01

    This report presents the 2010 groundwater monitoring results collected by the U.S. Department of Energy (DOE) Office of Legacy Management (LM) at the Project Shoal Area (PSA) Subsurface Corrective Action Unit (CAU) 447 in Churchill County, Nevada. Responsibility for the environmental site restoration of the PSA was transferred from the DOE Office of Environmental Management to LM on October 1, 2006. The environmental restoration process and corrective action strategy for CAU 447 are conducted in accordance with the Federal Facility Agreement and Consent Order (FFACO 1996, as amended March 2010) entered into by DOE, the U.S. Department of Defense, and the State of Nevada. The corrective action strategy for the site includes monitoring in support of site closure. This report summarizes the results from the groundwater monitoring program during fiscal year 2010.

  1. Late Miocene hominin teeth from the Gona Paleoanthropological Research Project area, Afar, Ethiopia.

    PubMed

    Simpson, Scott W; Kleinsasser, Lynnette; Quade, Jay; Levin, Naomi E; McIntosh, William C; Dunbar, Nelia; Semaw, Sileshi; Rogers, Michael J

    2015-04-01

    Since 2000, significant collections of Latest Miocene hominin fossils have been recovered from Chad, Kenya, and Ethiopia. These fossils have provided a better understanding of earliest hominin biology and context. Here, we describe five hominin teeth from two periods (ca. 5.4 Million-years-ago and ca. 6.3 Ma) that were recovered from the Adu-Asa Formation in the Gona Paleoanthropological Research Project area in the Afar, Ethiopia that we assign to either Hominina, gen. et sp. indet. or Ardipithecus kadabba. These specimens are compared with extant African ape and other Latest Miocene and Early Pliocene hominin teeth. The derived morphology of the large, non-sectorial maxillary canine and mandibular third premolar links them with later hominins and they are phenetically distinguishable and thus phyletically distinct from extant apes.

  2. 2009 Groundwater Monitoring Report Project Shoal Area, Corrective Action Unit 447

    SciTech Connect

    2010-03-01

    This report presents the 2009 groundwater monitoring results collected by the U.S. Department of Energy (DOE) Office of Legacy Management (LM) at the Project Shoal Area (PSA) Subsurface Corrective Action Unit (CAU) 447 in Churchill County, Nevada. Responsibility for the environmental site restoration of the PSA was transferred from the DOE Office of Environmental Management to LM on October 1, 2006. The environmental restoration process and corrective action strategy for CAU 447 are conducted in accordance with the Federal Facility Agreement and Consent Order (FFACO 1996, as amended February 2008) entered into by DOE, the U.S. Department of Defense, and the State of Nevada. The corrective action strategy for the site includes monitoring in support of site closure. This report summarizes investigation activities associated with CAU 447 that were conducted at the PSA during fiscal year 2009.

  3. YANGTZE project: Investigation of mass movements in the Three Gorges Reservoir Area (P. R. China)

    NASA Astrophysics Data System (ADS)

    Ehret, Dominik; Rohn, Joachim; Wiedenmann, Johannes; Rudolph, René; Otte, Karel; Ernstberger, Stefanie; Eckstein, Susan; Dumperth, Christian

    2010-05-01

    Within the German YANGTZE Project, mass movement hazard is investigated for the Xiangxi Catchment which is part of the Three Gorges Reservoir (P. R. China). The objective of our sub-project is to investigate the impact of the Three Gorges Reservoir on slope stability and (re-)activation of mass movements. Within this paper first results of investigations on mass movements in the Xiangxi Catchment that were started in summer 2008 are presented. They show a significant correlation between mass movement distribution and activity on the one hand and lithology and altitude on the other hand. In Xiangxi Catchment, correlation between geology and occurrence of mass movements can be studied ideally as most of the geological formations outcropping in the reservoir area can be found there. Furthermore, the mouth of Xiangxi River is quite close to the Three Gorges Dam so that the impact of the impoundment is distinctive in the Xiangxi Catchment. In 2008 and 2009, about 70 km² were mapped geotechnically. The mapping was done for (a) the backwater area of Xiangxi River influenced by the impoundment of the Three Gorges Reservoir (from Yangtze River to Gaoyang Town), (b) Quyuan Valley as a sub-catchment of Xiangxi Catchment, and (c) along the main roads from Gaoyang Town towards Gufu City and towards Shennongjia Nature Reserve. The investigated area comprises marine and continental sedimentary layers from Cambrian to Jurassic Period. The lithology of these layers is dominated by carbonates (limestone, dolostone and marlstone) on the one hand and clastic sediments (shale, mudstone, siltstone, sandstone, and conglomerate) on the other hand. A total of 180 mass movements was found and mapped. Mainly rotational or combined rotational-translational landslides, but also some rockslides and rockfalls were found. As expected, a strong correlation between lithology on the one side and occurrence and activity of mass movements on the other side could be found. In the study area, Jurassic

  4. Technical Area V (TA-V) transformation project close-out report.

    SciTech Connect

    Not Available

    2010-07-01

    Sandia National Laboratories (SNL) Technical Area V (TA-V) has provided unique nuclear experimental environments for decades. The technologies tested in TA-V facilities have furthered the United States Nuclear Weapons program and has contributed to the national energy and homeland security mission. The importance of TA-V working efficiently to produce an attractive and effective platform for experiments should not be underestimated. Throughout its brief history, TA-V has evolved to address multiple and diverse sets of requirements. These requirements evolved over many years; however, the requirements had not been managed nor communicated comprehensively or effectively. A series of programmatic findings over several years of external audits was evidence of this downfall. Today, these same requirements flow down through a new TA-V management system that produces consistently applied and reproducible approaches to work practices. In 2008, the TA-V department managers assessed the state of TA-V services and work activities to understand how to improve customer interfaces, stakeholders perceptions, and workforce efficiencies. The TA-V management team initiated the TA-V Transformation Project after they deemed the pre-June 2008 operational model to be ineffective in managing work and in providing integrated, continuous improvement to TA-V processes. This report summarizes the TA-V Transformation Project goals, activities, and accomplishments.

  5. Ethics Review of Research Projects Involving Human Subjects.

    ERIC Educational Resources Information Center

    Olivier, Steve

    2002-01-01

    Maltreatment of subjects has led to the introduction of an ethics review process for research involving humans. Institutional Review Boards (IRBs) require investigators to justify their human research to peers prior to recruiting participants. This paper describes the composition, functions, and duties of IRBs; the effectiveness and…

  6. The efferent projections of neurons in the white matter of different cortical areas of the adult rat.

    PubMed

    Meyer, G; Gonzalez-Hernandez, T; Galindo-Mireles, D; Castañeyra-Perdomo, A; Ferres-Torres, R

    1991-01-01

    Injection of Fast Blue into different cortical areas (frontal, parietal, anterior and posterior cingulate cortex) revealed that neurons in the white matter (interstitial neurons) give rise to association fibers which project mostly to the gray matter of the overlying cytoarchitectonic area, but which may extend also over different cytoarchitectonic areas. The rostrocaudal extent of the projecting axons was up to 1 mm in the frontal and parietal cortex, and up to 3.5 mm in the cingulate cortex. Concurrent processing for dihydronicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) histochemistry showed that 70% of cortically projecting interstitial neurons were NADPH-d-positive. An analysis of neuronal morphology suggests that the FasT-Blue-labeled, NADPH-d-negative neurons may represent displaced pyramidal neurons of layer VIb; the Fast-Blue-labeled and NADPH-d-positive neurons have bipolar or multipolar dendritic trees, constituting a population of nonpyramidal interstitial neurons that project into the cortical gray matter.

  7. Spotted hyaena space use in relation to human infrastructure inside a protected area

    PubMed Central

    Belton, Lydia E.; Cameron, Elissa Z.

    2016-01-01

    Increasing human population growth has led to elevated levels of human-carnivore conflict. However, some carnivore populations have adapted to urban environments and the resources they supply. Such associations may influence carnivore ecology, behaviour and life-history. Pockets of urbanisation sometimes occur within protected areas, so that anthropogenic influences on carnivore biology are not necessarily confined to unprotected areas. In this study we evaluated associations between human infrastructure and related activity and space use of spotted hyaenas within one of the largest protected areas in South Africa, the Kruger National Park. Home range size was smaller for the dominant female of a clan living in close proximity to humans than that of the dominant female of a clan without direct access to human infrastructure. The home range including human infrastructure was also used less evenly during the night, presumably when the animals were active. Within this home range, a village area was preferred during the night, when the least modified areas within the village were preferred and administration and highly modified areas were avoided. During the day, however, there were no preference or avoidance of the village area, but all habitats except unmodified habitats within the village area were avoided. We suggest that human infrastructure and associated activity influenced hyaena space use, primarily through alterations in the spatial distribution of food. However, these effects may have been indirectly caused by habitat modification that generated favourable hunting habitat rather than a direct effect caused by access to human food such as garbage. Because of the often pivotal effects of apex predators in terrestrial ecosystems, we encourage further work aimed to quantify how human presence influences large carnivores and associated ecosystem processes within protected areas. PMID:27781175

  8. Using Intergenerational Oral History Service-Learning Projects to Teach Human Behavior Concepts: A Qualitative Analysis

    ERIC Educational Resources Information Center

    Ames, Natalie; Diepstra, Stephene A.

    2006-01-01

    An intergenerational oral history project paired 63 students enrolled in human behavior in the social environment (HBSC) courses in a bachelor of social work (BSW) programs with older adults. The goal of the project was to provide contextual application of HBSE theories and concepts by engaging students in semester-long intentional interaction…

  9. A Collaborative Media Production Project on Human Rights: Bridging Everyday and Media Education

    ERIC Educational Resources Information Center

    Haydari, Nazan; Kara, Mustafa

    2015-01-01

    Given the importance of media institutions and universities as spaces of knowledge productions, development of "critical media pedagogy" becomes crucial for the establishment of a responsible and ethical media environment. Drawing from the collaborative project of The First Step into Human Rights: I do not do it!--A Short Film Project on…

  10. UNESCO and the Associated Schools Project: Symbolic Affirmation of World Community, International Understanding, and Human Rights

    ERIC Educational Resources Information Center

    Suarez, David F.; Ramirez, Francisco O.; Koo, Jeong-Woo

    2009-01-01

    The UNESCO Associated Schools Project emphasizes world community, human rights, and international understanding. This article investigates the emergence and global diffusion of the project from 1953 to 2001, estimating the influence of national, regional, and world characteristics on the likelihood of a country adopting a UNESCO school. It also…

  11. Human-motion energy harvester for autonomous body area sensors

    NASA Astrophysics Data System (ADS)

    Geisler, M.; Boisseau, S.; Perez, M.; Gasnier, P.; Willemin, J.; Ait-Ali, I.; Perraud, S.

    2017-03-01

    This paper reports on a method to optimize an electromagnetic energy harvester converting the low-frequency body motion and aimed at powering wireless body area sensors. This method is based on recorded accelerations, and mechanical and transduction models that enable an efficient joint optimization of the structural parameters. An optimized prototype of 14.8 mmØ × 52 mm, weighting 20 g, has generated up to 4.95 mW in a resistive load when worn at the arm during a run, and 6.57 mW when hand-shaken. Among the inertial electromagnetic energy harvesters reported so far, this one exhibits one of the highest power densities (up to 730 μW cm‑3). The energy harvester was finally used to power a bluetooth low energy wireless sensor node with accelerations measurements at 25 Hz.

  12. Mapping change in human pressure globally on land and within protected areas.

    PubMed

    Geldmann, Jonas; Joppa, Lucas N; Burgess, Neil D

    2014-12-01

    It is widely accepted that the main driver of the observed decline in biological diversity is increasing human pressure on Earth's ecosystems. However, the spatial patterns of change in human pressure and their relation to conservation efforts are less well known. We developed a spatially and temporally explicit map of global change in human pressure over 2 decades between 1990 and 2010 at a resolution of 10 km(2) . We evaluated 22 spatial data sets representing different components of human pressure and used them to compile a temporal human pressure index (THPI) based on 3 data sets: human population density, land transformation, and electrical power infrastructure. We investigated how the THPI within protected areas was correlated to International Union for Conservation of Nature (IUCN) management categories and the human development index (HDI) and how the THPI was correlated to cumulative pressure on the basis of the original human footprint index. Since the early 1990s, human pressure increased 64% of the terrestrial areas; the largest increases were in Southeast Asia. Protected areas also exhibited overall increases in human pressure, the degree of which varied with location and IUCN management category. Only wilderness areas and natural monuments (management categories Ib and III) exhibited decreases in pressure. Protected areas not assigned any category exhibited the greatest increases. High HDI values correlated with greater reductions in pressure across protected areas, while increasing age of the protected area correlated with increases in pressure. Our analysis is an initial step toward mapping changes in human pressure on the natural world over time. That only 3 data sets could be included in our spatio-temporal global pressure map highlights the challenge to measuring pressure changes over time.

  13. Helwan University Project Developing Primary School Pupils' Abilities and Skills at Some Egyptian Underprivileged Areas (Slums). (Field Study)

    ERIC Educational Resources Information Center

    El-Tayeb, Mahmoud N.; El Nashar, Mohamed; Zeid, Mai M.; El-Sayed, Magda; Ramadan, Mohamed A.; Hamdi, Safia M.; El-Affy, Nabila; Ebeid, Amina K.; El-Marasi, Sonia S.; Abou-Elmahty, Maher

    2010-01-01

    Through directing concerted efforts and educational services of seven Faculties of Helwan University towards socially underprivileged pupils in slum areas (EL-Marg area in big Cairo) this research project had two main aims: firstly, modifying a set of arbitrary behaviors of those pupils, in a trial to develop some behavior skills associated with…

  14. Human Variome Project country nodes: documenting genetic information within a country.

    PubMed

    Patrinos, George P; Smith, Timothy D; Howard, Heather; Al-Mulla, Fahd; Chouchane, Lotfi; Hadjisavvas, Andreas; Hamed, Sherifa A; Li, Xi-Tao; Marafie, Makia; Ramesar, Rajkumar S; Ramos, Feliciano J; de Ravel, Thomy; El-Ruby, Mona O; Shrestha, Tilak Ram; Sobrido, María-Jesús; Tadmouri, Ghazi; Witsch-Baumgartner, Martina; Zilfalil, Bin Alwi; Auerbach, Arleen D; Carpenter, Kevin; Cutting, Garry R; Dung, Vu Chi; Grody, Wayne; Hasler, Julia; Jorde, Lynn; Kaput, Jim; Macek, Milan; Matsubara, Yoichi; Padilla, Carmancita; Robinson, Helen; Rojas-Martinez, Augusto; Taylor, Graham R; Vihinen, Mauno; Weber, Tom; Burn, John; Qi, Ming; Cotton, Richard G H; Rimoin, David

    2012-11-01

    The Human Variome Project (http://www.humanvariomeproject.org) is an international effort aiming to systematically collect and share information on all human genetic variation. The two main pillars of this effort are gene/disease-specific databases and a network of Human Variome Project Country Nodes. The latter are nationwide efforts to document the genomic variation reported within a specific population. The development and successful operation of the Human Variome Project Country Nodes are of utmost importance to the success of Human Variome Project's aims and goals because they not only allow the genetic burden of disease to be quantified in different countries, but also provide diagnosticians and researchers access to an up-to-date resource that will assist them in their daily clinical practice and biomedical research, respectively. Here, we report the discussions and recommendations that resulted from the inaugural meeting of the International Confederation of Countries Advisory Council, held on 12th December 2011, during the 2011 Human Variome Project Beijing Meeting. We discuss the steps necessary to maximize the impact of the Country Node effort for developing regional and country-specific clinical genetics resources and summarize a few well-coordinated genetic data collection initiatives that would serve as paradigms for similar projects.

  15. Reconnaissance investigation of water quality, bottom sediment, and biota associated with irrigation drainage in the Dolores Project area, southwestern Colorado and southeastern Utah, 1990-91

    USGS Publications Warehouse

    Butler, D.L.; Krueger, R.P.; Osmundson, B.C.; Jensen, E.G.

    1995-01-01

    Water, bottom-sediment, and biota samples were collected in 1990-91 to identify water-quality problems associated with irrigation drainage in the Dolores Project area. Concentrations of cadmium, mercury, and selenium in some water samples exceeded aquatic-life criteria. Selenium was associated with irrigaton drainage from the Dolores Project, but other trace elements may be transported into the area in the irrigation water supply. Selenium concentrations exceeded the chronic aquatic-life criterion in water samples from lower McElmo Creek and Navajo Wash, which drain the Montezuma Valley, from newly irrigated areas, and from the Mancos River. The maximum selenium con- centration in water was 88 micrograms per liter from Navajo Wash. Concentrations of herbicides in water were less than concentrations harmful to aquatic life. Selenium concentrations in four bottom-sediment samples exceeded the baseline concentrations for soils in the Western United States. The largest selenium concentrations in biota were in samples from Navajo Wash, from newly irrigated areas north of the Montezuma Valley, and from the Mancos River basin. Selenium concentrations in aquatic-invertebrate samples from the newly irrigated areas exceeded a guideline for food items consumed by fish and wildlife. Selenium concen- trations in whole-body suckers were larger in the San Juan River downstream from the Dolores Project than upstream from the project at Four Corners. Selenium concentrations in fathead minnow samples from two sites were at adverse-effect levels. Mercury concentrations in warm-water game fish in reservoirs in the study area may be of concern to human health. Some concentrations of other trace elements exceeded background concentrations, but the concentrations were not toxicologically significant or the toxicologic significance is not known.

  16. Assessing Collembola biodiversity under human influence at Three Gorges Area, China.

    PubMed

    Huang, Cheng; Wang, Tianle; Luo, Yongzheng; Chen, Shi; Kim, Ke Chung

    2013-04-01

    In this study we comprehensively assessed Collembola biodiversity at Three Gorges Area, one of most diverse habitat regions in China. In total, 3,796 Collembola specimens comprising 9 families, 45 genera, and 103 species (including 14 new species and new records in China) were collected from three primary sampling areas: one nature reserve and two rural and urban areas representing different degrees of human influence. Each sampling area was further divided into nine sampling sites associated with different habitats and altitudes. Analyses of biodiversity data showed that individual abundance was highest in the nature reserve followed by mildly human influenced areas, and then highly influenced areas, and species richness was lowest in highly influenced areas. Hence, we suggest Collembola biodiversity is systematically lost after urbanization. In the nature reserve, altitude significantly influenced both the species richness and individual abundance, whereas in rural and urban areas, both altitude and the human-altered environmental gradient were influential. We also measured sampling efficiency and estimated potential species richness in these areas. This study serves as both a fundamental survey of Collembola biodiversity, as well as an assessment of human/environmental influence on the Collembola community, and can provide further insight into protecting the soil integrity of the Three Gorges Area.

  17. Characteristic Features of Innovation Project Management Aimed at University Human Resource Development

    ERIC Educational Resources Information Center

    Kalimullin, Aydar M.; Yungblud, Valery T.; Khodyreva, Elena A.

    2016-01-01

    The relevance of the studied issue is based on the need to develop theoretical approaches to project management at a higher educational institution taking into consideration the specifics of the subject area of the projects that ensure finding the "growth points" and addressing the long-term objectives of a university in the field of…

  18. Testosterone affects language areas of the adult human brain

    PubMed Central

    Hahn, Andreas; Kranz, Georg S.; Sladky, Ronald; Kaufmann, Ulrike; Ganger, Sebastian; Hummer, Allan; Seiger, Rene; Spies, Marie; Vanicek, Thomas; Winkler, Dietmar; Kasper, Siegfried; Windischberger, Christian; Swaab, Dick F.

    2016-01-01

    Abstract Although the sex steroid hormone testosterone is integrally involved in the development of language processing, ethical considerations mostly limit investigations to single hormone administrations. To circumvent this issue we assessed the influence of continuous high‐dose hormone application in adult female‐to‐male transsexuals. Subjects underwent magnetic resonance imaging before and after 4 weeks of testosterone treatment, with each scan including structural, diffusion weighted and functional imaging. Voxel‐based morphometry analysis showed decreased gray matter volume with increasing levels of bioavailable testosterone exclusively in Broca's and Wernicke's areas. Particularly, this may link known sex differences in language performance to the influence of testosterone on relevant brain regions. Using probabilistic tractography, we further observed that longitudinal changes in testosterone negatively predicted changes in mean diffusivity of the corresponding structural connection passing through the extreme capsule. Considering a related increase in myelin staining in rodents, this potentially reflects a strengthening of the fiber tract particularly involved in language comprehension. Finally, functional images at resting‐state were evaluated, showing increased functional connectivity between the two brain regions with increasing testosterone levels. These findings suggest testosterone‐dependent neuroplastic adaptations in adulthood within language‐specific brain regions and connections. Importantly, deteriorations in gray matter volume seem to be compensated by enhancement of corresponding structural and functional connectivity. Hum Brain Mapp 37:1738–1748, 2016. © 2016 Wiley Periodicals, Inc. PMID:26876303

  19. Human Factors Evaluation of Conflict Detection Tool for Terminal Area

    NASA Technical Reports Server (NTRS)

    Verma, Savita Arora; Tang, Huabin; Ballinger, Deborah; Chinn, Fay Cherie; Kozon, Thomas E.

    2013-01-01

    A conflict detection and resolution tool, Terminal-area Tactical Separation-Assured Flight Environment (T-TSAFE), is being developed to improve the timeliness and accuracy of alerts and reduce the false alert rate observed with the currently deployed technology. The legacy system in use today, Conflict Alert, relies primarily on a dead reckoning algorithm, whereas T-TSAFE uses intent information to augment dead reckoning. In previous experiments, T-TSAFE was found to reduce the rate of false alerts and increase time between the alert to the controller and a loss of separation over the legacy system. In the present study, T-TSAFE was tested under two meteorological conditions, 1) all aircraft operated under instrument flight regimen, and 2) some aircraft operated under mixed operating conditions. The tool was used to visually alert controllers to predicted Losses of separation throughout the terminal airspace, and show compression errors, on final approach. The performance of T-TSAFE on final approach was compared with Automated Terminal Proximity Alert (ATPA), a tool recently deployed by the FAA. Results show that controllers did not report differences in workload or situational awareness between the T-TSAFE and ATPA cones but did prefer T-TSAFE features over ATPA functionality. T-TSAFE will provide one tool that shows alerts in the data blocks and compression errors via cones on the final approach, implementing all tactical conflict detection and alerting via one tool in TRACON airspace.

  20. Testosterone affects language areas of the adult human brain.

    PubMed

    Hahn, Andreas; Kranz, Georg S; Sladky, Ronald; Kaufmann, Ulrike; Ganger, Sebastian; Hummer, Allan; Seiger, Rene; Spies, Marie; Vanicek, Thomas; Winkler, Dietmar; Kasper, Siegfried; Windischberger, Christian; Swaab, Dick F; Lanzenberger, Rupert

    2016-05-01

    Although the sex steroid hormone testosterone is integrally involved in the development of language processing, ethical considerations mostly limit investigations to single hormone administrations. To circumvent this issue we assessed the influence of continuous high-dose hormone application in adult female-to-male transsexuals. Subjects underwent magnetic resonance imaging before and after 4 weeks of testosterone treatment, with each scan including structural, diffusion weighted and functional imaging. Voxel-based morphometry analysis showed decreased gray matter volume with increasing levels of bioavailable testosterone exclusively in Broca's and Wernicke's areas. Particularly, this may link known sex differences in language performance to the influence of testosterone on relevant brain regions. Using probabilistic tractography, we further observed that longitudinal changes in testosterone negatively predicted changes in mean diffusivity of the corresponding structural connection passing through the extreme capsule. Considering a related increase in myelin staining in rodents, this potentially reflects a strengthening of the fiber tract particularly involved in language comprehension. Finally, functional images at resting-state were evaluated, showing increased functional connectivity between the two brain regions with increasing testosterone levels. These findings suggest testosterone-dependent neuroplastic adaptations in adulthood within language-specific brain regions and connections. Importantly, deteriorations in gray matter volume seem to be compensated by enhancement of corresponding structural and functional connectivity. Hum Brain Mapp 37:1738-1748, 2016. © 2016 Wiley Periodicals, Inc.

  1. Main contributions of the KfK nuclear safety project in the LWR safety area

    SciTech Connect

    Kuczera, B.

    1986-01-01

    The Nuclear Safety Project (PNS) was established at the Kernforschungszentrum Karlsruhe (KfK) in 1972. At that time, nuclear energy in the Federal Republic of Germany was in a transition phase proceeding from light water reactor (LWR) demonstration plants (300 MW(e)) to commercial size plants of 1200 to 1300 MW(e) which are standard units today. Simultaneously, general questions about LWR safety and reliability as well as questions on risk-oriented features became more pronounced in the public discussion. As a consequence, various already existing LWR safety activities were brought together and combined in the organizational framework of the PNS. The overriding objectives of PNS research and development (R and D) effort were at the quantification of safety margins of reactor systems and components, and the improvement of existing safety systems to avoid accident occurrence and to minimize accident consequences. In close cooperation with governmental authorities, manufacturers, and utilities, an R and D program was developed, comprised of four main areas: 1) dynamic behavior of reactor components; 2) fuel element behavior under accident conditions; 3) core meltdown accident analyses; and 4) retention of radioactive fission products and limitation of severe accident consequences. An overview on the KfK contribution to LWR safety research is given. It deals in a comprehensive matter with results obtained in the areas listed above.

  2. Evaluation of a Terminal Area In-Trail Approach Spacing, Project and Study

    NASA Technical Reports Server (NTRS)

    Shelden, Stephen; Johnson, Walter (Editor)

    2001-01-01

    Reported here are the results of work completed as a precursor to Distributed Air Ground (DAG), Concept Element 11 (CE11) research. CE11 is a NASA, Advanced Air Transportation Technologies (AATT) concept initiated to promote research on in-trail merging and spacing during approach in the terminal area environment, such that improvements to the National Air Space (NAS) may be realized. A description of the project concept, results of a preliminary study, and a literature review are presented. In terms of conclusions, study results, and reference material respectively: 1) the concept is supported as being significant to NAS capacity improvement, 2) the preliminary study indicated that having more than one downstream, in-trail aircraft present on a CDTI during approach may be advantageous, and that flying traditional Standard Terminal Arrival Routes (STAR) utilizing advanced decision support tools (DST) may be complicated by wake turbulence considerations, a lack of vertical awareness on the part of the flight crew, and the 'step-down' nature of many terminal area approaches, and 3) the results of a literature review are presented for future reference.

  3. Documentation assessment, Project C-018H, 200-E area effluent treatment facility

    SciTech Connect

    Peres, M.W.; Connor, M.D.; Mertelendy, J.I.

    1994-12-21

    Project C-018H is one of the fourteen subprojects to the Hanford Environmental Compliance (HEC) Project. Project C-018H provides treatment and disposal for the 242-A Evaporator and PUREX plant process condensate waste streams. This project used the Integrated Management Team (IMT) approach proposed by RL. The IMT approach included all affected organizations on the project team to coordinate and execute all required project tasks, while striving to integrate and satisfy all technical, operational, functional, and organizational objectives. The HEC Projects were initiated in 1989. Project C-018H began in early 1990, with completion of construction currently targeted for mid-1995. This assessment was performed to evaluate the effectiveness of the management control on design documents and quality assurance records developed and submitted for processing, use, and retention for the Project. The assessment focused primarily on the overall adequacy and quality of the design documentation currently being submitted to the project document control function.

  4. Next Generation Life Support Project: Development of Advanced Technologies for Human Exploration Missions

    NASA Technical Reports Server (NTRS)

    Barta, Daniel J.

    2012-01-01

    Next Generation Life Support (NGLS) is one of several technology development projects sponsored by the National Aeronautics and Space Administration s Game Changing Development Program. NGLS is developing life support technologies (including water recovery, and space suit life support technologies) needed for humans to live and work productively in space. NGLS has three project tasks: Variable Oxygen Regulator (VOR), Rapid Cycle Amine (RCA) swing bed, and Alternative Water Processing. The selected technologies within each of these areas are focused on increasing affordability, reliability, and vehicle self sufficiency while decreasing mass and enabling long duration exploration. The RCA and VOR tasks are directed at key technology needs for the Portable Life Support System (PLSS) for an Exploration Extravehicular Mobility Unit (EMU), with focus on prototyping and integrated testing. The focus of the Rapid Cycle Amine (RCA) swing-bed ventilation task is to provide integrated carbon dioxide removal and humidity control that can be regenerated in real time during an EVA. The Variable Oxygen Regulator technology will significantly increase the number of pressure settings available to the space suit. Current spacesuit pressure regulators are limited to only two settings while the adjustability of the advanced regulator will be nearly continuous. The Alternative Water Processor efforts will result in the development of a system capable of recycling wastewater from sources expected in future exploration missions, including hygiene and laundry water, based on natural biological processes and membrane-based post treatment. The technologies will support a capability-driven architecture for extending human presence beyond low Earth orbit to potential destinations such as the Moon, near Earth asteroids and Mars.

  5. West Valley Demonstration Project, Waste Management Area #3 -- Closure Alternative I

    SciTech Connect

    Marschke, Stephen F.

    2000-06-30

    The Draft Environmental Impact Statement for the completion of the West Valley Demonstration Project and closure and/or long-term management of facilities at the Western New York Nuclear Service Center divided the site into Waste Management Areas (WMAs), and for each WMA, presented the impacts associated with five potential closure alternatives. This report focuses on WMA 3 (the High-Level Waste (HLW) Storage Area (Tanks 8D-1 and 8D-2), the Vitrification Facility and other facilities) and closure Alternative I (the complete removal of all structures, systems and components and the release of the area for unrestricted use), and reestimates the impacts associated with the complete removal of the HLW tanks, and surrounding facilities. A 32-step approach was developed for the complete removal of Tanks 8D-1 and 8D-2, the Supernatant Treatment System Support Building, and the Transfer Trench. First, a shielded Confinement Structure would be constructed to reduce the shine dose rate and to control radioactivity releases. Similarly, the tank heels would be stabilized to reduce potential radiation exposures. Next, the tank removal methodology would include: 1) excavation of the vault cover soil, 2) removal of the vault roof, 3) cutting off the tank’s top, 4) removal of the stabilized heel remaining inside the tank, 5) cutting up the tank’s walls and floor, 6) removal of the vault’s walls, the perlite blocks, and vault floor, and 7) radiation surveying and backfilling the resulting hole. After the tanks are removed, the Confinement Structure would be decontaminated and dismantled, and the site backfilled and landscaped. The impacts (including waste disposal quantities, emissions, work-effort, radiation exposures, injuries and fatalities, consumable materials used, and costs) were estimated based on this 32 step removal methodology, and added to the previously estimated impacts for closure of the other facilities within WMA 3 to obtain the total impacts from

  6. Morphology of individual axons projecting from area V2 to MT in the macaque.

    PubMed

    Rockland, K S

    1995-04-24

    Efferent axons from area V2 to the middle temporal area (MT) were anterogradely labeled by Phaseolus vulgaris-leucoagglutinin (PHA-L) or biocytin and analyzed in serial reconstructions. Five of seven reconstructed axons had three arbors (each < or = 200 microns in diameter) in layers 3-4, separated by 200-600 microns. Two axons terminated in what was apparently a single focus in layers 3-4. Of 15 additional single arbors analyzed, 12 were concentrated in layers 3-4, and measured 200-250 microns across at their widest point. Three of these arbors were more columnar in shape (about 400 microns in diameter), and extended from layer 4 toward layer 1. This system differs in several features from MT-projecting axons originating from V1. Namely, V2 axons terminating in MT are thinner (approximately 1.0 microns vs. 3.0 microns), their terminal specializations are more delicate, and their arbors are concentrated in layer 4 and overlying layer 3, with no collaterals to layer 6. These differences may reflect the distinctive neuronal populations giving rise to these two connectional systems (different sizes of pyramidal neurons in layer 3 of V2, and a mix of pyramidal and spiny stellate cells in area V1). Differences may have implications for timing factors; that is, impulses from V1, subserved by large-caliber axons, may arrive in MT coincidentally with indirect connections via V2 to MT. Another consideration may be the functional architecture of MT. Regularly spaced clusters of neurons have been described in MT which have similar directionality preferences. The interarbor spacing of cortical efferents is consistent with a columnar organization, but the laminar specificity may indicate recruitment of different combinations of postsynaptic populations by V1 or V2 terminations.

  7. Somatotopic direct projections from orofacial areas of secondary somatosensory cortex to trigeminal sensory nuclear complex in rats.

    PubMed

    Haque, T; Akhter, F; Kato, T; Sato, F; Takeda, R; Higashiyama, K; Moritani, M; Bae, Y-C; Sessle, B J; Yoshida, A

    2012-09-06

    Little is known about the projections from the orofacial areas of the secondary somatosensory cortex (S2) to the pons and medulla including the second-order somatosensory neuron pools. To address this in rats, we first examined the distribution of S2 neurons projecting to the trigeminal principal nucleus (Vp) or oral subnucleus (Vo) of the trigeminal sensory nuclear complex (TSNC) after injections of a retrograde tracer, Fluorogold (FG), into five regions in the Vp/Vo which were responsive to stimulation of trigeminal nerves innervating the orofacial tissues. A large number of FG-labeled neurons were found with a somatotopic arrangement in the dorsal areas of S2 (orofacial S2 area). This somatotopic arrangement in the orofacial S2 area was shown to closely match that of the orofacial afferent inputs by recording cortical surface potentials evoked by stimulation of the trigeminal nerves. We then examined the morphology of descending projections from these electrophysiologically defined areas of the orofacial S2 to the pons and medulla after injections of an anterograde tracer, biotinylated dextranamine (BDA), into the areas. A large number of BDA-labeled axon fibers and terminals were seen only in some of the second-order somatosensory neuron pools, most notably in the contralateral TSNC, although the labeled terminals were not seen in certain rostrocaudal levels of the contralateral TSNC including the rostrocaudal middle level of the trigeminal interpolar subnucleus. The projections to the TSNC showed somatotopic arrangements in dorsoventral, superficial-deep and rostrocaudal directions. The somatotopic arrangements in the Vp/Vo closely matched those of the electrophysiologically defined central projection sites of the orofacial trigeminal afferents in the TSNC. The present results suggest that the orofacial S2 projects selectively to certain rostrocaudal levels of the contralateral TSNC, and the projections may allow the orofacial S2 to accurately modulate

  8. The Human Microbiome Project strategy for comprehensive sampling of the human microbiome and why it matters.

    PubMed

    Aagaard, Kjersti; Petrosino, Joseph; Keitel, Wendy; Watson, Mark; Katancik, James; Garcia, Nathalia; Patel, Shital; Cutting, Mary; Madden, Tessa; Hamilton, Holli; Harris, Emily; Gevers, Dirk; Simone, Gina; McInnes, Pamela; Versalovic, James

    2013-03-01

    The Human Microbiome Project used rigorous good clinical practice standards to complete comprehensive body site sampling in healthy 18- to 40-yr-old adults, creating an unparalleled reference set of microbiome specimens. To ensure that specimens represented minimally perturbed microbiomes, we first screened potential participants using exclusion criteria based on health history, including the presence of systemic diseases (e.g., hypertension, cancer, or immunodeficiency or autoimmune disorders), use of potential immunomodulators, and recent use of antibiotics or probiotics. Subsequent physical examinations excluded individuals based on body mass index (BMI), cutaneous lesions, and oral health. We screened 554 individuals to enroll 300 (149 men and 151 women, mean age 26 yr, mean BMI 24 kg/m, 20.0% racial minority, and 10.7% Hispanic). We obtained specimens from the oral cavity, nares, skin, gastrointestinal tract, and vagina (15 specimens from men and 18 from women). The study evaluated longitudinal changes in an individual's microbiome by sampling 279 participants twice (mean 212 d after the first sampling; range 30-359 d) and 100 individuals 3 times (mean 72 d after the second sampling; range 30-224 d). This sampling strategy yielded 11,174 primary specimens, from which 12,479 DNA samples were submitted to 4 centers for metagenomic sequencing. Our clinical design and well-defined reference cohort has laid a foundation for microbiome research.

  9. Sensitivity projections for dark matter dearches with the Fermi large area telescope

    DOE PAGES

    Charles, E.; M. Sanchez-Conde; Anderson, B.; ...

    2016-05-20

    The nature of dark matter is a longstanding enigma of physics; it may consist of particles beyond the Standard Model that are still elusive to experiments. Among indirect search techniques, which look for stable products from the annihilation or decay of dark matter particles, or from axions coupling to high-energy photons, observations of themore » $$\\gamma$$-ray sky have come to prominence over the last few years, because of the excellent sensitivity of the Large Area Telescope (LAT) on the Fermi Gamma-ray Space Telescope mission. The LAT energy range from 20 MeV to above 300 GeV is particularly well suited for searching for products of the interactions of dark matter particles. In this report we describe methods used to search for evidence of dark matter with the LAT, and review the status of searches performed with up to six years of LAT data. We also discuss the factors that determine the sensitivities of these searches, including the magnitudes of the signals and the relevant backgrounds, considering both statistical and systematic uncertainties. We project the expected sensitivities of each search method for 10 and 15 years of LAT data taking. In particular, we find that the sensitivity of searches targeting dwarf galaxies, which provide the best limits currently, will improve faster than the square root of observing time. Current LAT limits for dwarf galaxies using six years of data reach the thermal relic level for masses up to 120 GeV for the $$b\\bar{b}$$ annihilation channel for reasonable dark matter density profiles. With projected discoveries of additional dwarfs, these limits could extend to about 250 GeV. With as much as 15 years of LAT data these searches would be sensitive to dark matter annihilations at the thermal relic cross section for masses to greater than 400 GeV (200 GeV) in the $$b\\bar{b}$$ ($$\\tau^+ \\tau^-$$) annihilation channels.« less

  10. Leptin Responsive and GABAergic Projections to the Rostral Preoptic Area in Mice.

    PubMed

    Zuure, W A; Quennell, J H; Anderson, G M

    2016-03-01

    The adipocyte-derived hormone leptin plays a critical role in the control of reproduction via signalling in hypothalamic neurones. The drivers of the hypothalamic-pituitary-gonadal axis, the gonadotrophin-releasing hormone (GnRH) neurones, do not have the receptors for leptin. Therefore, intermediate leptin responsive neurones must provide leptin-to-GnRH signalling. We investigated the populations of leptin responsive neurones that provide input to the rostral preoptic area (rPOA) where GnRH cell bodies reside. Fluorescent retrograde tracer beads (RetroBeads; Lumafluor Inc., Naples, FL, USA) were injected into the rPOA of transgenic leptin receptor enhanced green fluorescent protein (Lepr-eGFP) reporter mice. Uptake of the RetroBeads by Lepr-eGFP neurones was assessed throughout the hypothalamus. RetroBead uptake was most evident in the medial arcuate nucleus (ARC), the dorsomedial nucleus (DMN) and the ventral premammillary nucleus (PMV) of the hypothalamus. The uptake of RetroBeads specifically by Lepr-eGFP neurones was highest in the medial ARC (18% of tracer-labelled neurones Lepr-eGFP-positive). Because neurones that are both leptin responsive and GABAergic play a critical role in the regulation of fertility by leptin, we next focussed on the location of these populations. To address whether GABAergic neurones in leptin-responsive hypothalamic regions project to the rPOA, the experiment was repeated in GABA neurone reporter mice (Vgat-tdTomato). Between 10% and 45% of RetroBead-labelled neurones in the ARC were GABAergic, whereas uptake of tracer by GABAergic neurones in the DMN and PMV was very low (< 5%). These results show that both leptin responsive and GABAergic neurones from the ARC project to the region of the GnRH cell bodies. Our findings suggest that LEPR-expressing GABA neurones from the ARC may be mediators of leptin-to-GnRH signalling.

  11. Sensitivity projections for dark matter dearches with the Fermi large area telescope

    SciTech Connect

    Charles, E.; M. Sanchez-Conde; Anderson, B.; Caputo, R.; Cuoco, A.; Di Mauro, M.; Drlica-Wagner, A.; Gomez-Vargas, G. A.; Meyer, M.; Tibaldo, L.; Wood, M.; Zaharijas, G.; Zimmer, S.; Ajello, M.; Albert, A.; Baldini, L.; Bechtol, K.; Bloom, E. D.; Ceraudo, F.; Cohen-Tanugi, J.; Gaskins, J.; Gustafsson, M.; Mirabal, N.; Razzano, M.

    2016-05-20

    The nature of dark matter is a longstanding enigma of physics; it may consist of particles beyond the Standard Model that are still elusive to experiments. Among indirect search techniques, which look for stable products from the annihilation or decay of dark matter particles, or from axions coupling to high-energy photons, observations of the $\\gamma$-ray sky have come to prominence over the last few years, because of the excellent sensitivity of the Large Area Telescope (LAT) on the Fermi Gamma-ray Space Telescope mission. The LAT energy range from 20 MeV to above 300 GeV is particularly well suited for searching for products of the interactions of dark matter particles. In this report we describe methods used to search for evidence of dark matter with the LAT, and review the status of searches performed with up to six years of LAT data. We also discuss the factors that determine the sensitivities of these searches, including the magnitudes of the signals and the relevant backgrounds, considering both statistical and systematic uncertainties. We project the expected sensitivities of each search method for 10 and 15 years of LAT data taking. In particular, we find that the sensitivity of searches targeting dwarf galaxies, which provide the best limits currently, will improve faster than the square root of observing time. Current LAT limits for dwarf galaxies using six years of data reach the thermal relic level for masses up to 120 GeV for the $b\\bar{b}$ annihilation channel for reasonable dark matter density profiles. With projected discoveries of additional dwarfs, these limits could extend to about 250 GeV. With as much as 15 years of LAT data these searches would be sensitive to dark matter annihilations at the thermal relic cross section for masses to greater than 400 GeV (200 GeV) in the $b\\bar{b}$ ($\\tau^+ \\tau^-$) annihilation channels.

  12. Advanced Solid State Lighting for Human Evaluation Project

    NASA Technical Reports Server (NTRS)

    Zeitlin, Nancy; Holbert, Eirik

    2015-01-01

    Lighting intensity and color have a significant impact on human circadian rhythms. Advanced solid state lighting was developed for the Advanced Exploration System (AES) Deep Space Habitat(DSH) concept demonstrator. The latest generation of assemblies using the latest commercially available LED lights were designed for use in the Bigelow Aerospace Environmental Control and Life Support System (ECLSS) simulator and the University of Hawaii's Hawaii Space Exploration Analog and Simulation (Hi-SEAS) habitat. Agreements with both these organizations will allow the government to receive feedback on the lights and lighting algorithms from long term human interaction.

  13. Through Human Eyes: A New Approach to the Problem of Workforces in Remote Areas.

    ERIC Educational Resources Information Center

    Simmonds, W. H. C.

    The often unstable workforce in remote areas can possibly be strengthened by stabilizing adjacent human settlements with community design which works from the inside out to emphasize the human, social, cultural, and environmental aspects of the settlements. Because stresses resulting from isolation, loss of social relationships, lack of…

  14. The Human Genome Project: Past, Present, and Future

    NASA Astrophysics Data System (ADS)

    Watson, James D.

    1990-04-01

    This article presents a short discussion of the development of the human genome program in the United States, a summary of the current status of the organization and administration of the National Institutes of Health component of the program, and some prospects for the future directions of the program and the applications of genome information.

  15. The Human Behavior Curriculum Project. Instructional Units and Teacher Handbooks.

    ERIC Educational Resources Information Center

    American Psychological Association, Washington, DC.

    Each of these eight units dealing with human behavior is designed for high school psychology courses and consists of a teacher handbook and a student booklet. The developers believe that the systematic study of behavior can increase students' understanding of the lives they lead. Each unit was prepared by a different team consisting of two high…

  16. Conceptual planning for Space Station life sciences human research project

    NASA Technical Reports Server (NTRS)

    Primeaux, Gary R.; Miller, Ladonna J.; Michaud, Roger B.

    1986-01-01

    The Life Sciences Research Facility dedicated laboratory is currently undergoing system definition within the NASA Space Station program. Attention is presently given to the Humam Research Project portion of the Facility, in view of representative experimentation requirement scenarios and with the intention of accommodating the Facility within the Initial Operational Capability configuration of the Space Station. Such basic engineering questions as orbital and ground logistics operations and hardware maintenance/servicing requirements are addressed. Biospherics, calcium homeostasis, endocrinology, exercise physiology, hematology, immunology, muscle physiology, neurosciences, radiation effects, and reproduction and development, are among the fields of inquiry encompassed by the Facility.

  17. A Cultural Resources Literature Search of the Bayou Du Chien Drainage Project Area in Fulton, Graves, and Hickman Counties, Kentucky

    DTIC Science & Technology

    1985-10-10

    Mary E., and Roger W. Barbour 1971 A Guide to the Wildflowers and Ferns of Kentucky . The University Press of Kentucky , Lexington. I. 59 I Wharton, Mary...DRAINAGE PROJECT AREA IN FULTON, GRAVES, AND HICKMAN COUNTIES, KENTUCKY I by ?amela A. Schenian October 10, 1985 - DTIC S APRL 9 19933 I E i Cultural... KENTUCKY by Pamela A. Schenian Pamela A.’ Schenia Principal Investigator and Project Archaeologist October 10, 1985 Prepared for: The Memphis

  18. Deactivation in the Sensorimotor Area during Observation of a Human Agent Performing Robotic Actions

    ERIC Educational Resources Information Center

    Shimada, Sotaro

    2010-01-01

    It is well established that several motor areas, called the mirror-neuron system (MNS), are activated when an individual observes other's actions. However, whether the MNS responds similarly to robotic actions compared with human actions is still controversial. The present study investigated whether and how the motor area activity is influenced by…

  19. Evaluation of the United States Department Of Agriculture Northeast Area-wide Tick Control Project by meta-analysis.

    PubMed

    Brei, Brandon; Brownstein, John S; George, John E; Pound, J Mathews; Miller, J Allen; Daniels, Thomas J; Falco, Richard C; Stafford, Kirby C; Schulze, Terry L; Mather, Thomas N; Carroll, John F; Fish, Durland

    2009-08-01

    As part of the Northeast Area-wide Tick Control Project (NEATCP), meta-analyses were performed using pooled data on the extent of tick-vector control achieved through seven concurrent studies, conducted within five states, using U.S. Department of Agriculture "4-Poster" devices to deliver targeted-acaricide to white-tailed deer. Although reductions in the abundance of all life-stages of Ixodes scapularis were the measured outcomes, this study focused on metrics associated with I. scapularis nymphal tick densities as this measure has consistently proven to directly correlate with human risk of acquiring Lyme disease. Since independent tick sampling schemes were undertaken at each of the five environmentally distinct study locations, a meta-analytic approach permitted estimation of a single true control-effect size for each treatment year of the NEATCP. The control-effect is expressed as the annual percent I. scapularis nymphal control most consistent with meta-analysis data for each treatment year. Our meta-analyses indicate that by the sixth treatment year, the NEATCP effectively reduced the relative density of I. scapularis nymphs by 71% on the 5.14 km(2) treatment sites, corresponding to a 71% lower relative entomologic risk index for acquiring Lyme disease.

  20. L-325 Sagebrush Habitat Mitigation Project: Final Compensation Area Monitoring Report

    SciTech Connect

    Durham, Robin E.; Becker, James M.

    2013-09-26

    This document provides a review and status of activities conducted in support of the Fluor Daniel Hanford Company (Fluor), now Mission Support Alliance (MSA), Mitigation Action Plan (MAP) for Project L-325, Electrical Utility Upgrades (2007). Three plantings have been installed on a 4.5-hectare mitigation area to date. This review provides a description and chronology of events, monitoring results, and mitigative actions through fiscal year (FY) 2012. Also provided is a review of the monitoring methods, transect layout, and FY 2012 monitoring activities and results for all planting years. Planting densities and performance criteria stipulated in the MAP were aimed at a desired future condition (DFC) of 10 percent mature sagebrush (Artemisia tridentata ssp wyomingensis) cover. Current recommendations for yielding this DFC are based upon a conceptual model planting of 1000 plants/ha (400/ac) exhibiting a 60-percent survival rate after 5 monitoring years (DOE 2003). Accordingly, a DFC after 5 monitoring years would not be less than 600 plants/ha (240/ac). To date, about 8700 sagebrush plants have been grown and transplanted onto the mitigation site. Harsh site conditions and low seedling survival have resulted in an estimated 489 transplants/ha on the mitigation site, which is 111 plants/ha short of the target DFC. Despite this apparent shortcoming, 71, 91, and 24 percent of the surviving seedlings planted in FY 2007 and FY 2008 and FY 2010, respectively, showed signs of blooming in FY 2012. Blooming status may be a positive indication of future sagebrush recruitment, and is therefore a potential source for reaching the target DFC of 600 plants/ha on this mitigation site over time. Because of the difficulty establishing small transplants on this site, we propose that no additional plantings be considered for this mitigation area and to rely upon the potential recruitment by established seedlings to achieve the mitigation commitment set forth in the MAP of 600 plants/ha.

  1. Toward Elimination of Dog-Mediated Human Rabies: Experiences from Implementing a Large-scale Demonstration Project in Southern Tanzania

    PubMed Central

    Mpolya, Emmanuel Abraham; Lembo, Tiziana; Lushasi, Kennedy; Mancy, Rebecca; Mbunda, Eberhard M.; Makungu, Selemani; Maziku, Matthew; Sikana, Lwitiko; Jaswant, Gurdeep; Townsend, Sunny; Meslin, François-Xavier; Abela-Ridder, Bernadette; Ngeleja, Chanasa; Changalucha, Joel; Mtema, Zacharia; Sambo, Maganga; Mchau, Geofrey; Rysava, Kristyna; Nanai, Alphoncina; Kazwala, Rudovick; Cleaveland, Sarah; Hampson, Katie

    2017-01-01

    A Rabies Elimination Demonstration Project was implemented in Tanzania from 2010 through to 2015, bringing together government ministries from the health and veterinary sectors, the World Health Organization, and national and international research institutions. Detailed data on mass dog vaccination campaigns, bite exposures, use of post-exposure prophylaxis (PEP), and human rabies deaths were collected throughout the project duration and project areas. Despite no previous experience in dog vaccination within the project areas, district veterinary officers were able to implement district-wide vaccination campaigns that, for most part, progressively increased the numbers of dogs vaccinated with each phase of the project. Bite exposures declined, particularly in the southernmost districts with the smallest dog populations, and health workers successfully transitioned from primarily intramuscular administration of PEP to intradermal administration, resulting in major cost savings. However, even with improved PEP provision, vaccine shortages still occurred in some districts. In laboratory diagnosis, there were several logistical challenges in sample handling and submission but compared to the situation before the project started, there was a moderate increase in the number of laboratory samples submitted and tested for rabies in the project areas with a decrease in the proportion of rabies-positive samples over time. The project had a major impact on public health policy and practice with the formation of a One Health Coordination Unit at the Prime Minister’s Office and development of the Tanzania National Rabies Control Strategy, which lays a roadmap for elimination of rabies in Tanzania by 2030 by following the Stepwise Approach towards Rabies Elimination (SARE). Overall, the project generated many important lessons relevant to rabies prevention and control in particular and disease surveillance in general. Lessons include the need for (1) a specific unit in the

  2. Human African trypanosomiasis in a Belgian traveller returning from the Masai Mara area, Kenya, February 2012.

    PubMed

    Clerinx, J; Vlieghe, E; Asselman, V; Van de Casteele, S; Maes, M B; Lejon, V

    2012-03-08

    A Belgian traveller was diagnosed with human African trypanosomiasis (HAT) due to Trypanosoma brucei rhodesiense nine days after visiting the Masai Mara area in Kenya. He presented with an inoculation chancre and was treated with suramin within four days of fever onset. Two weeks earlier, HAT was also reported in a German traveller who had visited the Masai Mara area. Because no cases have occurred in the area for over 12 years, this may indicate a focal cluster of HAT.

  3. Hydrologic Resources Management Program and Underground Test Area Project FY 2006 Progress Report

    SciTech Connect

    Culham, H W; Eaton, G F; Genetti, V; Hu, Q; Kersting, A B; Lindvall, R E; Moran, J E; Blasiyh Nuno, G A; Powell, B A; Rose, T P; Singleton, M J; Williams, R W; Zavarin, M; Zhao, P

    2008-04-08

    This report describes FY 2006 technical studies conducted by the Chemical Biology and Nuclear Science Division (CBND) at Lawrence Livermore National Laboratory (LLNL) in support of the Hydrologic Resources Management Program (HRMP) and the Underground Test Area Project (UGTA). These programs are administered by the U.S. Department of Energy, National Nuclear Security Administration, Nevada Site Office (NNSA/NSO) through the Defense Programs and Environmental Restoration Divisions, respectively. HRMP-sponsored work is directed toward the responsible management of the natural resources at the Nevada Test Site (NTS), enabling its continued use as a staging area for strategic operations in support of national security. UGTA-funded work emphasizes the development of an integrated set of groundwater flow and contaminant transport models to predict the extent of radionuclide migration from underground nuclear testing areas at the NTS. The report is organized on a topical basis and contains four chapters that highlight technical work products produced by CBND. However, it is important to recognize that most of this work involves collaborative partnerships with the other HRMP and UGTA contract organizations. These groups include the Energy and Environment Directorate at LLNL (LLNL-E&E), Los Alamos National Laboratory (LANL), the Desert Research Institute (DRI), the U.S. Geological Survey (USGS), Stoller-Navarro Joint Venture (SNJV), and National Security Technologies (NSTec). Chapter 1 is a summary of FY 2006 sampling efforts at near-field 'hot' wells at the NTS, and presents new chemical and isotopic data for groundwater samples from four near-field wells. These include PM-2 and U-20n PS 1DDh (CHESHIRE), UE-7ns (BOURBON), and U-19v PS No.1ds (ALMENDRO). Chapter 2 is a summary of the results of chemical and isotopic measurements of groundwater samples from three UGTA environmental monitoring wells. These wells are: ER-12-4 and U12S located in Area 12 on Rainier Mesa and

  4. 2015 Groundwater Monitoring Report Project Shoal Area: Subsurface Correction Unit 447

    SciTech Connect

    Findlay, Rick

    2016-04-01

    The Project Shoal Area in Nevada was the site of a 12-kiloton-yield underground nuclear test in 1963. Although the surface of the site has been remediated, investigation of groundwater contamination resulting from the test is still in the corrective action process. Annual sampling and hydraulic head monitoring are conducted at the site as part of the subsurface corrective action strategy. The corrective action strategy is currently focused on revising the site conceptual model (SCM) and evaluating the adequacy of the monitoring well network. Some aspects of the SCM are known; however, two major concerns are the uncertainty in the groundwater flow direction and the cause of rising water levels in site wells west of the shear zone. Water levels have been rising in the site wells west of the shear zone since the first hydrologic characterization wells were installed in 1996. Although water levels in wells west of the shear zone continue to rise, the rate of increase is less than in previous years. The SCM will be revised, and an evaluation of the groundwater monitoring network will be conducted when water levels at the site have stabilized to the agreement of both the U.S. Department of Energy Office of Legacy Management and the Nevada Division of Environmental Protection.

  5. Optimal pipe size design for looped irrigation water supply system using harmony search: Saemangeum project area.

    PubMed

    Yoo, Do Guen; Lee, Ho Min; Sadollah, Ali; Kim, Joong Hoon

    2015-01-01

    Water supply systems are mainly classified into branched and looped network systems. The main difference between these two systems is that, in a branched network system, the flow within each pipe is a known value, whereas in a looped network system, the flow in each pipe is considered an unknown value. Therefore, an analysis of a looped network system is a more complex task. This study aims to develop a technique for estimating the optimal pipe diameter for a looped agricultural irrigation water supply system using a harmony search algorithm, which is an optimization technique. This study mainly serves two purposes. The first is to develop an algorithm and a program for estimating a cost-effective pipe diameter for agricultural irrigation water supply systems using optimization techniques. The second is to validate the developed program by applying the proposed optimized cost-effective pipe diameter to an actual study region (Saemangeum project area, zone 6). The results suggest that the optimal design program, which applies an optimization theory and enhances user convenience, can be effectively applied for the real systems of a looped agricultural irrigation water supply.

  6. Optimal Pipe Size Design for Looped Irrigation Water Supply System Using Harmony Search: Saemangeum Project Area

    PubMed Central

    Lee, Ho Min; Sadollah, Ali

    2015-01-01

    Water supply systems are mainly classified into branched and looped network systems. The main difference between these two systems is that, in a branched network system, the flow within each pipe is a known value, whereas in a looped network system, the flow in each pipe is considered an unknown value. Therefore, an analysis of a looped network system is a more complex task. This study aims to develop a technique for estimating the optimal pipe diameter for a looped agricultural irrigation water supply system using a harmony search algorithm, which is an optimization technique. This study mainly serves two purposes. The first is to develop an algorithm and a program for estimating a cost-effective pipe diameter for agricultural irrigation water supply systems using optimization techniques. The second is to validate the developed program by applying the proposed optimized cost-effective pipe diameter to an actual study region (Saemangeum project area, zone 6). The results suggest that the optimal design program, which applies an optimization theory and enhances user convenience, can be effectively applied for the real systems of a looped agricultural irrigation water supply. PMID:25874252

  7. Aviation System Capacity Program Terminal Area Productivity Project: Ground and Airborne Technologies

    NASA Technical Reports Server (NTRS)

    Giulianetti, Demo J.

    2001-01-01

    Ground and airborne technologies were developed in the Terminal Area Productivity (TAP) project for increasing throughput at major airports by safely maintaining good-weather operating capacity during bad weather. Methods were demonstrated for accurately predicting vortices to prevent wake-turbulence encounters and to reduce in-trail separation requirements for aircraft approaching the same runway for landing. Technology was demonstrated that safely enabled independent simultaneous approaches in poor weather conditions to parallel runways spaced less than 3,400 ft apart. Guidance, control, and situation-awareness systems were developed to reduce congestion in airport surface operations resulting from the increased throughput, particularly during night and instrument meteorological conditions (IMC). These systems decreased runway occupancy time by safely and smoothly decelerating the aircraft, increasing taxi speed, and safely steering the aircraft off the runway. Simulations were performed in which optimal trajectories were determined by air traffic control (ATC) and communicated to flight crews by means of Center TRACON Automation System/Flight Management System (CTASFMS) automation to reduce flight delays, increase throughput, and ensure flight safety.

  8. Records available to September 30, 1956, on use of water in the Delaware Basin Project area

    USGS Publications Warehouse

    Kammerer, John C.

    1957-01-01

    The purpose of this report is to summarize data on the use of water in the Delaware Basin Project area (fig. 2) and to list the principal data sources that are available in published form. The tables and bibliography will assist Geological Survey personnel assigned to the Delaware Basin Project in evaluating the scope and deficiencies of previous studies of the basin. Information is also given on the use of water by public supplies in the New York-New Jersey region comprising the New York City Metropolitan Area and in the remaining north-central and south-eastern parts of New Jersey. These regions may depend increasingly on water from the Delaware River basin for part of their public supplies. The Geological Survey has the responsibility for appraising and describing the water resources of the Nation as a guide to use, development, control, and conservation of these resources. Cooperative Federal-State water-resources investigations in the Delaware Basin States have been carried on the the Geological Survey for more than 50 years. In July 1956 the Survey began the "Delaware Basin Project," a hydrologic study of the Delaware River basin in order to: 1) Determine present status and trends in water availability, quality, and use, 2) assess and improve the adequacy of the Survey's basic water data program in the basin, 3) interpret and evaluate the water-resources data in terms of past and possible future water-use and land-use practices, and 4) disseminate promptly the results of this investigation for the benefit of all interested agencies and the general public. The Geological Survey is working closely with the U.S. Corps of Engineers and other cooperating Federal and State agencies in providing water data which will contribute to the present coordinated investigation aimed at developing a plan for long-range water development in the Delaware River basin. Estimates of quantities of water used are given for water withdrawn from streams and aquifers during calendar

  9. Projecting Human Development and CO2 emissions employing correlations

    NASA Astrophysics Data System (ADS)

    Rybski, D.; Costa, L.; Kropp, J. P.

    2012-04-01

    We find positive and time dependent correlation between the Human Development Index (HDI) and per capita CO2 emissions from fossil fuel combustion. Based on this empirical relation, extrapolated HDI, and three population scenarios extracted from the Millennium Ecosystem Assessment report, we estimate future cumulative CO2 emissions. If current demographic and development trends are maintained, we estimate that by 2050 around 85% of the world's population will live in countries with high HDI (above 0.8) as defined in the United Nations Human Development Report 2009. In particular, we estimate that at least 300Gt of cumulative CO2 emissions between 2000 and 2050 are necessary for the development of developing countries in the year 2000. This value represents 30% of a previously calculated CO2 budget yielding a 75% probability of limiting global warming to 2°C. Since human development has been proved to be time and country dependent, we plead for future climate negotiations to consider a differentiated CO2 emissions reduction scheme for developing countries based on the achievement of concrete development goals.

  10. A decade of human genome project conclusion: Scientific diffusion about our genome knowledge.

    PubMed

    Moraes, Fernanda; Góes, Andréa

    2016-05-06

    The Human Genome Project (HGP) was initiated in 1990 and completed in 2003. It aimed to sequence the whole human genome. Although it represented an advance in understanding the human genome and its complexity, many questions remained unanswered. Other projects were launched in order to unravel the mysteries of our genome, including the ENCyclopedia of DNA Elements (ENCODE). This review aims to analyze the evolution of scientific knowledge related to both the HGP and ENCODE projects. Data were retrieved from scientific articles published in 1990-2014, a period comprising the development and the 10 years following the HGP completion. The fact that only 20,000 genes are protein and RNA-coding is one of the most striking HGP results. A new concept about the organization of genome arose. The ENCODE project was initiated in 2003 and targeted to map the functional elements of the human genome. This project revealed that the human genome is pervasively transcribed. Therefore, it was determined that a large part of the non-protein coding regions are functional. Finally, a more sophisticated view of chromatin structure emerged. The mechanistic functioning of the genome has been redrafted, revealing a much more complex picture. Besides, a gene-centric conception of the organism has to be reviewed. A number of criticisms have emerged against the ENCODE project approaches, raising the question of whether non-conserved but biochemically active regions are truly functional. Thus, HGP and ENCODE projects accomplished a great map of the human genome, but the data generated still requires further in depth analysis. © 2016 by The International Union of Biochemistry and Molecular Biology, 44:215-223, 2016.

  11. Project Management Meets Change Management - A Success Story. Focus Area: Tech Perspectives TI012SN

    NASA Technical Reports Server (NTRS)

    Hall, Wayne

    2011-01-01

    Utilizing the concepts and terminology from Project Management, the process of planning and executing a Change Management (CM) Infrastructure improvement project is described. The primary audience for this presentation includes both experienced and relatively new CM administrators and their managers. It also includes anyone with an interest in the application of project management knowledge to CM administration. There are several benefits: the complexity of the CM tool technology is more manageable, CM administrators get to use project management knowledge to complete a project (not "firefighting"), improve relations with your customers (that means developers and managers), and get the opportunity to do it again.

  12. An analysis of eco-environmental impacts of the south-to-north water transfer project on the receiving areas

    NASA Astrophysics Data System (ADS)

    Wang, Lin; Gan, Hong; Xiao, Yuquan; You, Jinjun

    2010-05-01

    The receiving areas of the Phase I projects of the eastern and central routes of the South-to-North Water Transfer Project cover 41 administrative regions at and above the prefecture level in the provincial level administrative regions of Beijing, Tianjin, Hebei, Shandong and Henan, and have a carrying capacity of water resources most unadaptive to the needs by the economic and social development. Those areas have densely distributed population, farmland and agricultural and industrial activities and are experiencing rapid urbanization, but suffer from high scarcity of water resources, with all the cities in the areas seeing water shortage to a varying extent. Most of the cities are relying on abstracting deep groundwater and occupying agricultural water for urban water supply. In December 2002, the State Council officially approved the General Plan on the South-to-North Water Transfer Project, which provides multiple measures to reduce groundwater over-abstraction and improve and gradually restore the eco-environment in the receiving areas by using transferred water to replace the agricultural water occupied by urban water supply and the eco-environmental water occupied by cities and agriculture. What changes have occurred to the eco-environment and urban water use in the receiving areas in recent years ? How much water can be returned from the cities to agriculture and ecology after the objectives of water supply are met? What can be achieved in the control of groundwater abstraction? What level of guarantee can the water transfer provide for agricultural water use in a dry year? All of those issues have been at the focus of public attention. In this paper, statistical analysis is made on the eco-environmental status and urban water use of 72 cities in the receiving areas of the Phase I projects since year 2000 and a conclusion is drawn that the renewal capacity of the eco-environment and groundwater in the receiving areas is deteriorating. Then the water

  13. Preservation of Records, Knowledge and Memory Across Generations. An emerging Multidisciplinary Work Area and an NEA Project - 12218

    SciTech Connect

    Schroeder, Jantine; Pescatore, Claudio

    2012-07-01

    Disposal in engineered facilities built in stable, deep geological formations is the reference means for permanently isolating long-lived radioactive waste from the human biosphere. This management method is designed to be intrinsically safe and final, i.e. not dependent on human presence and intervention in order to fulfil its safety goal. There is however no intention to forgo, at any time, knowledge and awareness either of the repository or of the waste that it contains. The preservation of Records, Knowledge and Memory (RK and M) is seen as an integral part of radioactive waste management, supporting lengthy and complex socio-technical processes across pre-operational, operational and post-operational lifetimes. Long-term preservation of RK and M is an emerging multidisciplinary work area in which much learning is expected over the coming years. Novel methods are being sought that are least vulnerable to both natural degradation and to changes in socio-economic conditions. Progress has been made in individual countries, but there is a need to internationalise the thinking, compare approaches, investigate potential solutions and share decisions. This is the task of the NEA RK and M project. A major outcome of the project will be a 'menu-driven document' that will allow people to identify the main elements of a strategic action plan for RK and M preservation. In sum, the preservation of RK and M is a unprecedented task in which technical, scientific and social information is interwoven and needs to be developed and preserved across generations and across specialist boundaries. Important studies have been undertaken in the past decades to explore a variety of approaches to preserving RK and M across different timescales, including archives and markers. The work of the past in this area is useful, but innovative thinking is also needed. Seen from today's perspective, very little work is available on for example the contextualization of data for later use; on the

  14. Human body and head characteristics as a communication medium for Body Area Network.

    PubMed

    Kifle, Yonatan; Hun-Seok Kim; Yoo, Jerald

    2015-01-01

    An in-depth investigation of the Body Channel Communication (BCC) under the environment set according to the IEEE 802.15.6 Body Area Network (BAN) standard is conducted to observe and characterize the human body as a communication medium. A thorough measurement of the human head as part of the human channel is also carried out. Human forehead, head to limb, and ear to ear channel is characterized. The channel gain of the human head follows the same bandpass profile of the human torso and limbs with the maximum channel gain occurring at 35MHz. The human body channel gain distribution histogram at given frequencies, while all the other parameters are held constant, exhibits a maximum variation of 2.2dB in the channel gain at the center frequency of the bandpass channel gain profile.

  15. Human genome education model project. Ethical, legal, and social implications of the human genome project: Education of interdisciplinary professionals

    SciTech Connect

    Weiss, J.O.; Lapham, E.V.

    1996-12-31

    This meeting was held June 10, 1996 at Georgetown University. The purpose of this meeting was to provide a multidisciplinary forum for exchange of state-of-the-art information on the human genome education model. Topics of discussion include the following: psychosocial issues; ethical issues for professionals; legislative issues and update; and education issues.

  16. "This Ever More Amorphous Thing called Digital Humanities": Whither the Humanities Project?

    ERIC Educational Resources Information Center

    Deegan, Marilyn

    2014-01-01

    In 2012, Digital Humanities became one of the most talked-about topics in the humanities and was suggested as a movement that could possibly help halt the decline in the traditional humanities. A flurry of books appeared, and "AHHE" produced two special issues, "Digital humanities," "digital futures" and "The…

  17. The somatotopic organization of cytoarchitectonic areas on the human parietal operculum.

    PubMed

    Eickhoff, Simon B; Grefkes, Christian; Zilles, Karl; Fink, Gereon R

    2007-08-01

    The secondary somatosensory cortex (SII) of nonhuman primates is located on the parietal operculum. In the monkey, electrophysiological and connectivity tracing studies as well as histological investigations provide converging evidence for 3 distinct cortical areas (SII, PV, and VS) within this region, each of which contains a complete somatotopic map. Although the equivalency of the parietal operculum as the location of SII between humans and nonhuman primates is undisputed, the internal organization of the human SII region is still largely unknown. Based on their topography, we have previously argued that the cytoarchitectonic areas OP 1, OP 4, and OP 3 may constitute the human homologues of areas SII, PV, and VS, respectively. To test this hypothesis, we here examined (using functional magnetic resonance imaging) the somatotopic organization of the human parietal operculum by applying tactile stimulation to the skin at 4 different locations on either side of the body (face, hands, trunk, and legs). The locations of the resulting activation foci were then compared with the cytoarchitectonic maps of this region. Data analysis revealed 2 somatotopic body representations on the lateral operculum in areas OP 1 and OP 4. The functional border between these 2 body maps was defined by a mirror reversal in the somatotopic arrangement and coincided with the cytoarchitectonically defined border between these 2 areas. This somatotopic arrangement closely matches that described for SII and PV in nonhuman primates. The data also suggested a third somatotopic map located deeper inside the Sylvian fissure in area OP 3. Based on the observed topographic arrangement and their functional response characteristics, we conclude that cytoarchitectonic areas OP1, OP 4, and OP 3 on the human parietal operculum constitute the human homologues of primate areas SII, PV, and VS, respectively.

  18. Faces in Motion: Selectivity of Macaque and Human Face Processing Areas for Dynamic Stimuli

    PubMed Central

    Polosecki, Pablo; Moeller, Sebastian; Schweers, Nicole; Romanski, Lizabeth M.; Tsao, Doris Y.

    2013-01-01

    Face recognition mechanisms need to extract information from static and dynamic faces. It has been hypothesized that the analysis of dynamic face attributes is performed by different face areas than the analysis of static facial attributes. To date, there is no evidence for such a division of labor in macaque monkeys. We used fMRI to determine specializations of macaque face areas for motion. Face areas in the fundus of the superior temporal sulcus responded to general object motion; face areas outside of the superior temporal sulcus fundus responded more to facial motion than general object motion. Thus, the macaque face-processing system exhibits regional specialization for facial motion. Human face areas, processing the same stimuli, exhibited specializations for facial motion as well. Yet the spatial patterns of facial motion selectivity differed across species, suggesting that facial dynamics are analyzed differently in humans and macaques. PMID:23864665

  19. Faces in motion: selectivity of macaque and human face processing areas for dynamic stimuli.

    PubMed

    Polosecki, Pablo; Moeller, Sebastian; Schweers, Nicole; Romanski, Lizabeth M; Tsao, Doris Y; Freiwald, Winrich A

    2013-07-17

    Face recognition mechanisms need to extract information from static and dynamic faces. It has been hypothesized that the analysis of dynamic face attributes is performed by different face areas than the analysis of static facial attributes. To date, there is no evidence for such a division of labor in macaque monkeys. We used fMRI to determine specializations of macaque face areas for motion. Face areas in the fundus of the superior temporal sulcus responded to general object motion; face areas outside of the superior temporal sulcus fundus responded more to facial motion than general object motion. Thus, the macaque face-processing system exhibits regional specialization for facial motion. Human face areas, processing the same stimuli, exhibited specializations for facial motion as well. Yet the spatial patterns of facial motion selectivity differed across species, suggesting that facial dynamics are analyzed differently in humans and macaques.

  20. [Provision of integrity and reliability in hygienic examination of investment projects for human capital development].

    PubMed

    Tarkhov, P V; Matsenko, A M; Krugliak, A P; Derkach, Zh V

    2012-01-01

    To reach normal competitiveness in world division of labour, investment projects should stimulate development of human capital towards advance of modern technologies and organizational development of all types of labour. At present time there are only separate calculations of certain types of people's health damage and completely disparate matters of damage compensation exceptionally for chemical contamination effects. The purpose of the paper is development of algorithms to provide hygienic welfare of human capital in investment projects. For this purpose in investments assessment and hygienic examination it is necessary to apply complete and comprehensive (systematic) evaluation of all factors that influence human capital welfare and practical hygienic and research institutions should be focused on systematic elimination of possible dangers and risks of investment projects.

  1. Projections of 21st Century African Climate: Implications for African Savanna Fire Dynamics, Human Health and Food Security

    NASA Astrophysics Data System (ADS)

    Adegoke, J. O.

    2015-12-01

    Fire is a key agent of change in the African savannas, which are shaped through the complex interactions between trees, C4 grasses, rainfall, temperature, CO2 and fire. These fires and their emitted smoke can have numerous direct and indirect effects on the environment, water resources, air quality, and climate. For instance, veld fires in southern Africa cause large financial losses to agriculture, livestock production and forestry on an annual basis. This study contributes to our understanding of the implications of projected surface temperature evolution in Africa for fire risk, human health and agriculture over the coming decades. We use an ensemble of high-resolution regional climate model simulations of African climate for the 21st century. Regional dowscalings and recent global circulation model projections obtained for Africa indicate that African temperatures are likely to rise at 1.5 times the global rate of temperature increase in the tropics, and at almost twice the global rate of increase in the subtropics. Warming is projected to occur during the 21st century, with increases of 4-6 °C over the subtropics and 3-5 °C over the tropics plausible by the end of the century relative to present-day climate under the A2 (low mitigation) scenario. We explore the significance of the projected warming by documenting increases in projected high fire danger days and heat-wave days. General drying is projected across the continent, even for areas (e.g. tropical Africa) where an increase in rainfall is plausible. This is due to the drastic increases in temperature that are projected, which leads to drier soils (through enhanced evaporation) despite the rainfall increases. This will likely impact negatively on crop yield, particularly on the maize crop that is of crucial importance in terms of African food security.

  2. Nevada Test Site Area 25, Radiological Survey and Cleanup Project, 1974-1983 (a revised final report). Revision 1

    SciTech Connect

    Miller, M.G.

    1984-12-01

    This report describes the radiological survey, decontamination and decommissioning (D and D) of the Nevada Test Site (NTS) Area 25 facilities and land areas incorporated in the Nuclear Rocket Development Station (NRDS). Buildings, facilities and support systems used after 1959 for nuclear reactor and engine testing were surveyed for the presence of radioactive contamination. The radiological survey portion of the project encompassed portable instrument surveys and removable contamination surveys (swipe) for beta plus gamma and alpha radioactive contamination of facilities, equipment and land areas. Soil sampling was also accomplished. The majority of Area 25 facilities and land areas have been returned to unrestricted use. Remaining radiologically contaminated areas are posted with warning signs and barricades. 9 references, 23 figures.

  3. Class 1 overview of cultural resources for the Western Area Power Administration Salt Lake City Area Integrated Projects electric power marketing environmental impact statement

    SciTech Connect

    Moeller, K.L.; Malinowski, L.M.; Hoffecker, J.F.; Walitschek, D.A.; Shogren, L.; Mathews, J.E.; Verhaaren, B.T.

    1993-11-01

    Argonne National Laboratory conducted an inventory of known archaeological and historic sites in areas that could be affected by the hydropower operation alternatives under analysis in the power marketing environmental impact statement for the Western Area Power Administration`s Salt Lake City Area Integrated Projects. The study areas included portions of the Green River (Flaming Gorge Dam to Cub Creek) in Utah and Colorado and the Gunnison River (Blue Mesa Reservoir to Crystal Dam) in Colorado. All previous archaeological surveys and previously recorded prehistoric and historic sites, structures, and features were inventoried and plotted on maps (only survey area maps are included in this report). The surveys were classified by their level of intensity, and the sites were classified according to their age, type, and contents. These data (presented here in tabular form) permit a general assessment of the character and distribution of archaeological remains in the study areas, as well as an indication of the sampling basis for such an assessment. To provide an adequate context for the descriptions of the archaeological and historic sites, this report also presents overviews of the environmental setting and the regional prehistory, history, and ethnography for each study area.

  4. Community based needs assessment in an urban area; A participatory action research project

    PubMed Central

    2012-01-01

    Background Community assessment is a core function of public health. In such assessments, a commitment to community participation and empowerment is at the heart of the WHO European Healthy Cities Network, reflecting its origins in health for all and the Ottawa Charter for Health Promotion. This study employs a participation and empowerment plan in order to conduct community assessment. Methods The method of participatory action research (PAR) was used. The study was carried out in an area of high socio-economic deprivation in Ardabil, a city in the northwest of Iran, which is currently served by a branch of the Social Development Center (SDC). The steering committee of the project was formed by some university faculty members, health officials and delegates form Farhikhteh non-governmental organization and representatives from twelve blocks or districts of the community. Then, the representatives were trained and then conducted focus groups in their block. The focus group findings informed the development of the questionnaire. About six hundred households were surveyed and study questionnaires were completed either during face-to-face interviews by the research team (in case of illiteracy) or via self-completion. The primary question for the residents was: 'what is the most important health problem in your community? Each health problem identified by the community was weighted based on the frequency it was selected on the survey, and steering committee perception of the problem's seriousness, urgency, solvability, and financial load. Results The main problems of the area appeared to be the asphalt problem, lack of easy access to medical centers, addiction among relatives and unemployment of youth. High participation rates of community members in the steering committee and survey suggest that the PAR approach was greatly appreciated by the community and that problems identified through this research truly reflect community opinion. Conclusions Participatory action

  5. P.C.A.P. Project Profiles and General Profilles. Queensland Priority Country Area Program-Evaluation Series.

    ERIC Educational Resources Information Center

    Saide, Tom, Ed.

    Thirty-eight projects designed to improve educational opportunities of rural Queensland children were initiated in 1977 and funded through the Disadvantaged Schools Program; the program was renamed the Country Area Program and made a permanent School Commission program in 1982. The program resulted from a 1977-79 Schools Commission report…

  6. Analysis of an Interactive Technology Supported Problem-Based Learning STEM Project Using Selected Learning Sciences Interest Areas (SLSIA)

    ERIC Educational Resources Information Center

    Kumar, David Devraj

    2017-01-01

    This paper reports an analysis of an interactive technology-supported, problem-based learning (PBL) project in science, technology, engineering and mathematics (STEM) from a Learning Sciences perspective using the Selected Learning Sciences Interest Areas (SLSIA). The SLSIA was adapted from the "What kinds of topics do ISLS [International…

  7. Differences and Commonalities: Farmer Stratifications in the San Luis Valley Research/Extension Project Area. ARE Research Report.

    ERIC Educational Resources Information Center

    Eckert, Jerry B.

    A research project in the San Luis Valley of Colorado sought to isolate a few unique farm types that could become target groups for the design and implementation of agricultural research and extension programs. Questionnaires were completed by 44 of 65 farmers in one watershed area of Conejos County. Analysis revealed a complex pattern of…

  8. Urban dogs in rural areas: Human-mediated movement defines dog populations in southern Chile.

    PubMed

    Villatoro, Federico J; Sepúlveda, Maximiliano A; Stowhas, Paulina; Silva-Rodríguez, Eduardo A

    2016-12-01

    Management strategies for dog populations and their diseases include reproductive control, euthanasia and vaccination, among others. However, the effectiveness of these strategies can be severely affected by human-mediated dog movement. If immigration is important, then the location of origin of dogs imported by humans will be fundamental to define the spatial scales over which population management and research should apply. In this context, the main objective of our study was to determine the spatial extent of dog demographic processes in rural areas and the proportion of dogs that could be labeled as immigrants at multiple spatial scales. To address our objective we conducted surveys in households located in a rural landscape in southern Chile. Interviews allowed us to obtain information on the demographic characteristics of dogs in these rural settings, human influence on dog mortality and births, the localities of origin of dogs living in rural areas, and the spatial extent of human-mediated dog movement. We found that most rural dogs (64.1%) were either urban dogs that had been brought to rural areas (40.0%), or adopted dogs that had been previously abandoned in rural roads (24.1%). Some dogs were brought from areas located as far as ∼700km away from the study area. Human-mediated movement of dogs, especially from urban areas, seems to play a fundamental role in the population dynamics of dogs in rural areas. Consequently, local scale efforts to manage dog populations or their diseases are unlikely to succeed if implemented in isolation, simply because dogs can be brought from surrounding urban areas or even distant locations. We suggest that efforts to manage or study dog populations and related diseases should be implemented using a multi-scale approach.

  9. The impact of the human genome project on complex disease.

    PubMed

    Bailey, Jessica N Cooke; Pericak-Vance, Margaret A; Haines, Jonathan L

    2014-07-16

    In the decade that has passed since the initial release of the Human Genome, numerous advancements in science and technology within and beyond genetics and genomics have been encouraged and enhanced by the availability of this vast and remarkable data resource. Progress in understanding three common, complex diseases: age-related macular degeneration (AMD), Alzheimer's disease (AD), and multiple sclerosis (MS), are three exemplars of the incredible impact on the elucidation of the genetic architecture of disease. The approaches used in these diseases have been successfully applied to numerous other complex diseases. For example, the heritability of AMD was confirmed upon the release of the first genome-wide association study (GWAS) along with confirmatory reports that supported the findings of that state-of-the art method, thus setting the foundation for future GWAS in other heritable diseases. Following this seminal discovery and applying it to other diseases including AD and MS, the genetic knowledge of AD expanded far beyond the well-known APOE locus and now includes more than 20 loci. MS genetics saw a similar increase beyond the HLA loci and now has more than 100 known risk loci. Ongoing and future efforts will seek to define the remaining heritability of these diseases; the next decade could very well hold the key to attaining this goal.

  10. GENCODE: the reference human genome annotation for The ENCODE Project.

    PubMed

    Harrow, Jennifer; Frankish, Adam; Gonzalez, Jose M; Tapanari, Electra; Diekhans, Mark; Kokocinski, Felix; Aken, Bronwen L; Barrell, Daniel; Zadissa, Amonida; Searle, Stephen; Barnes, If; Bignell, Alexandra; Boychenko, Veronika; Hunt, Toby; Kay, Mike; Mukherjee, Gaurab; Rajan, Jeena; Despacio-Reyes, Gloria; Saunders, Gary; Steward, Charles; Harte, Rachel; Lin, Michael; Howald, Cédric; Tanzer, Andrea; Derrien, Thomas; Chrast, Jacqueline; Walters, Nathalie; Balasubramanian, Suganthi; Pei, Baikang; Tress, Michael; Rodriguez, Jose Manuel; Ezkurdia, Iakes; van Baren, Jeltje; Brent, Michael; Haussler, David; Kellis, Manolis; Valencia, Alfonso; Reymond, Alexandre; Gerstein, Mark; Guigó, Roderic; Hubbard, Tim J

    2012-09-01

    The GENCODE Consortium aims to identify all gene features in the human genome using a combination of computational analysis, manual annotation, and experimental validation. Since the first public release of this annotation data set, few new protein-coding loci have been added, yet the number of alternative splicing transcripts annotated has steadily increased. The GENCODE 7 release contains 20,687 protein-coding and 9640 long noncoding RNA loci and has 33,977 coding transcripts not represented in UCSC genes and RefSeq. It also has the most comprehensive annotation of long noncoding RNA (lncRNA) loci publicly available with the predominant transcript form consisting of two exons. We have examined the completeness of the transcript annotation and found that 35% of transcriptional start sites are supported by CAGE clusters and 62% of protein-coding genes have annotated polyA sites. Over one-third of GENCODE protein-coding genes are supported by peptide hits derived from mass spectrometry spectra submitted to Peptide Atlas. New models derived from the Illumina Body Map 2.0 RNA-seq data identify 3689 new loci not currently in GENCODE, of which 3127 consist of two exon models indicating that they are possibly unannotated long noncoding loci. GENCODE 7 is publicly available from gencodegenes.org and via the Ensembl and UCSC Genome Browsers.

  11. Project ADAPT: A Program to Assess Depression and Provide Proactive Treatment in Rural Areas

    ERIC Educational Resources Information Center

    Luptak, Marilyn; Kaas, Merrie J.; Artz, Margaret; McCarthy, Teresa

    2008-01-01

    Purpose: We describe and evaluate a project designed to pilot test an evidence-based clinical intervention for assessing and treating depression in older adults in rural primary care clinics. Project ADAPT--Assuring Depression Assessment and Proactive Treatment--utilized existing primary care resources to overcome barriers to sustainability…

  12. The transverse and oblique cylindrical equal-area projection of the ellipsoid.

    USGS Publications Warehouse

    Snyder, J.P.

    1985-01-01

    The formulas for the ellipsoidal projection are derived for both forward and inverse computations and consist of modifying the formulas obtained by using the authalic sphere so that the scale along the central line of the projection is constant. Fourier series are used to eliminate recurring numerical integration and other lengthy trigonometric computations of co-ordinates.-from Author

  13. Fluid Management Plan for the Project Shoal Area, Off-sites Subproject, CAU 447, Revision 0 (with Record of Technical Change No. 1, 2, and 3)

    SciTech Connect

    USDOE /NV

    1999-04-01

    The U.S. Department of Energy, Nevada Operations Office (DOE/NV) has initiated the Off-Site Project to characterize the hazards posed to human health and the environment as a result of underground nuclear testing activities at facilities other than the Nevada Test Site (NTS). The Project Shoal Area (PSA) is one of the Off-Sites Project areas located off the NTS, but within the state of Nevada. The PSA is located approximately 48 kilometers (30 miles) southeast of Fallon, Nevada. Four wells were drilled at the PSA in 1996 as part of the site investigation administered through the Federal Facility Agreement and Consent Order (FFACO) (1996). The hydrogeologic data gathered from these wells was used to support the groundwater flow and contaminant transport modeling of the PSA. However, the subsequent evaluation of the groundwater model concluded that further delineation of the subsurface was required to reduce uncertainties in the model. In accordance with the FFACO, an addendum to the Corrective Action Investigation Plan (CAIP) for the proposed PSA subsurface investigation, Corrective Action Unit 447, was developed. The addendum proposed the drilling and construction of four additional wells and the conduct of hydrologic testing at the PSA. This Fluid Management Plan (FMP) provides guidance for the management of fluids generated from the well construction and testing activities at the PSA.

  14. Demographic and socio-economic determinants of post-neonatal deaths in a special project area of rural northern India.

    PubMed

    Kabir, Zubair

    2003-07-01

    The demographic and socio-economic determinants of post-neonatal deaths (n = 475) in a special project area of rural northern India (Ballabgarh) were ascertained from 1991 to 1999 using the electronic database system of the project area for data extraction, and were compared with the eligible living children of the same age using a matched population-based case-control study design. Similar determinants were also ascertained in neonatal deaths (n = 212) using the same study design. After controlling for the potential confounders using conditional logistic regression analyses, lower caste (a proxy measure for low socio-economic conditions in rural India) was found to be significantly associated with higher post-neonatal deaths (OR = 2.21). Higher maternal age (>30 years) and fathers' lower educational levels were significantly associated with higher neonatal deaths, in addition to higher post-neonatal deaths in the same area.

  15. An aerial radiological survey of the West Valley Demonstration Project and surrounding area, West Valley, New York

    SciTech Connect

    Berry, H.A.

    1991-09-01

    An aerial radiological survey of the West Valley Demonstration Project and the surrounding area was conducted from mid-August through early September 1984 by EG G Energy Measurements, Inc. for the United States Department of Energy. The radiological survey was part of the United States Department of Energy Comprehensive Integrated Remote Sensing (CIRS) program, which provides state-of-the-art remote sensing to support the needs of the various DOE facilities. The survey consisted of airborne measurements of both natural and man-made gamma radiation emanating from the terrestrial surface. These measurements allowed an estimate of the distribution of isotopic concentrations in the area surrounding the project site. Results are reported as isopleths superimposed on aerial photographs of the area. Gamma ray energy spectra are also presented for the net man-made radionuclides. 8 refs., 16 figs., 9 tabs.

  16. Human-Related Factors Regulate the Spatial Ecology of Domestic Cats in Sensitive Areas for Conservation

    PubMed Central

    Ferreira, Joaquim P.; Leitão, Inês; Santos-Reis, Margarida; Revilla, Eloy

    2011-01-01

    Background Domestic cats ranging freely in natural areas are a conservation concern due to competition, predation, disease transmission or hybridization with wildcats. In order to improve our ability to design effective control policies, we investigate the factors affecting their numbers and space use in natural areas of continental Europe. Methodology/Principal Findings We describe the patterns of cat presence, abundance and space use and analyse the associated environmental and human constraints in a well-preserved Mediterranean natural area with small scattered local farms. We failed in detecting cats in areas away from human settlements (trapping effort above 4000 trap-nights), while we captured 30 individuals near inhabited farms. We identified 130 cats, all of them in farms still in use by people (30% of 128 farms). All cats were free-ranging and very wary of people. The main factor explaining the presence of cats was the presence of people, while the number of cats per farm was mostly affected by the occasional food provisioning with human refuse and the presence of people. The home ranges of eight radio tagged cats were centred at inhabited farms. Males went furthest away from the farms during the mating season (3.8 km on average, maximum 6.3 km), using inhabited farms as stepping-stones in their mating displacements (2.2 km of maximum inter-farm distance moved). In their daily movements, cats notably avoided entering in areas with high fox density. Conclusions The presence, abundance and space use of cats were heavily dependent on human settlements. Any strategy aiming at reducing their impact in areas of conservation concern should aim at the presence of settlements and their spatial spread and avoid any access to human refuse. The movements of domestic cats would be limited in areas with large patches of natural vegetation providing good conditions for other carnivore mammals such as red foxes. PMID:22043298

  17. Interspecies activity correlations reveal functional correspondence between monkey and human brain areas.

    PubMed

    Mantini, Dante; Hasson, Uri; Betti, Viviana; Perrucci, Mauro G; Romani, Gian Luca; Corbetta, Maurizio; Orban, Guy A; Vanduffel, Wim

    2012-02-05

    Evolution-driven functional changes in the primate brain are typically assessed by aligning monkey and human activation maps using cortical surface expansion models. These models use putative homologous areas as registration landmarks, assuming they are functionally correspondent. For cases in which functional changes have occurred in an area, this assumption prohibits to reveal whether other areas may have assumed lost functions. Here we describe a method to examine functional correspondences across species. Without making spatial assumptions, we assessed similarities in sensory-driven functional magnetic resonance imaging responses between monkey (Macaca mulatta) and human brain areas by temporal correlation. Using natural vision data, we revealed regions for which functional processing has shifted to topologically divergent locations during evolution. We conclude that substantial evolution-driven functional reorganizations have occurred, not always consistent with cortical expansion processes. This framework for evaluating changes in functional architecture is crucial to building more accurate evolutionary models.

  18. Interim response action basin F liquid incineration project final draft human health risk assessment. Volume 1. Final draft report

    SciTech Connect

    1991-07-01

    This document is a comprehensive, multiple exposure pathway, human health risk assessment prepared for the proposed Basin F Liquid Incineration Project. The submerged quench incinerator will treat Basin F liquid and hydrazine rinse water. The objective of the risk assessment is to establish chemical emission limits which are protective of human health. Average and maximum lifetime daily intakes were calculated for adults, children, and infants in four maximum exposure scenarios under base case and sensitivity case emissions condition. It was concluded that the incineration facility poses neither carcinogenic nor noncarcinogenic risk to any sensitive population. The assessment is divided into: (1) Incineration facility description; (2) Description of surrounding area; (3) Process of pollutant identification and selection; and (4) Determination of emission rates from incineration facility.

  19. Project Notes

    ERIC Educational Resources Information Center

    School Science Review, 1977

    1977-01-01

    Listed and described are student A-level biology projects in the following areas: Angiosperm studies (e.g., factors affecting growth of various plants), 7; Bacterial studies, 1; Insect studies, 2; Fish studies, 1; Mammal studies, 1; Human studies, 1; Synecology studies, 2; Environmental studies, 2; and Enzyme studies, 1. (CS)

  20. Relationships between human population density and burned area at continental and global scales.

    PubMed

    Bistinas, Ioannis; Oom, Duarte; Sá, Ana C L; Harrison, Sandy P; Prentice, I Colin; Pereira, José M C

    2013-01-01

    We explore the large spatial variation in the relationship between population density and burned area, using continental-scale Geographically Weighted Regression (GWR) based on 13 years of satellite-derived burned area maps from the global fire emissions database (GFED) and the human population density from the gridded population of the world (GPW 2005). Significant relationships are observed over 51.5% of the global land area, and the area affected varies from continent to continent: population density has a significant impact on fire over most of Asia and Africa but is important in explaining fire over < 22% of Europe and Australia. Increasing population density is associated with both increased and decreased in fire. The nature of the relationship depends on land-use: increasing population density is associated with increased burned are in rangelands but with decreased burned area in croplands. Overall, the relationship between population density and burned area is non-monotonic: burned area initially increases with population density and then decreases when population density exceeds a threshold. These thresholds vary regionally. Our study contributes to improved understanding of how human activities relate to burned area, and should contribute to a better estimate of atmospheric emissions from biomass burning.

  1. Common Software Development Methods for Human, Vehicle and Mission Safety Critical Space Projects

    NASA Astrophysics Data System (ADS)

    Boudillet, Olivier; Peron, Thierry; McMahon, Barry

    2013-09-01

    This paper will address how the methods and tools used for the ATV project can be tailored to other projects to fit their specific needs and costs. The examples of the HOMER lander demonstrator project (and its successful free flight in October 2012) and the ExoMars Rover project will be used (from ASTRIUM ST and ASTRIUM Ltd).The paper will survey the major phases of the development by ASTRIUM of various safety critical softwares (either human, vehicle or mission level related):• The specification phase, with more particularly the use of the Model Driven Environment (MDE) approach with SCADE® from ANSYS.• The coding and Unit testing phase (both from manual coding or autocoding from MDE).• The validation phase, with more AGILE like approach, and how to perform fast and automated validation loops, thanks to specific tools.This paper will conclude on how the human safety critical software development approach can be profitable to vehicle or mission safety critical projects, even if no human life is directly at sake.

  2. Project Work Plan 100-N Area Strontium-90 Treatability Demonstration Project: Phytoremediation Along the 100-N Columbia River Riparian Zone

    SciTech Connect

    Ainsworth, Calvin C.

    2006-04-30

    The 100-N Area Innovative Treatment and Remediation Demonstration (ITRD) identified phyto¬remediation as a potential technology both for the removal of 90Sr from the soil of the riparian zone and as a filter for groundwater along the Columbia River. Recent greenhouse and growth chamber studies have demonstrated the viability of phytoextraction to remove 90Sr from this area’s soil/water; in conjunction with monitored natural attenuation and an apatite barrier the process would make an effective treatment for remediation of the 100-N Area 90Sr plume. All activities associated with the 100-NR-1 and 100-NR-2 Operable Units of the Hanford 100-N Area have had, and continue to have, significant regulatory and stakeholder participation. Beginning in 1998 with the ITRD process, presentations to the ITRD TAG were heavily attended by EPA, Washington State Department of Ecology, and stakeholders. In addition, three workshops have been held to receive regulatory and stakeholder feedback on monitored natural attenuation, the apatite barrier, and phytoremediation; these were held in Richland in August 2003, December 2004, and August 2005. The apatite injection treatability test plan (DOE 2005) describes phytoremediation as a technology to be evaluated during the March 2008 evaluation milestone as described in the Tri-Party Agreement change request (M-16-06-01 Change Control Form). If, during this evaluation milestone, phytoremediation is favorably evaluated it would be incorporated into the treatability test plan. The phytoremediation treatability test described in this proposal is strongly supported by the Washington State Department of Ecology.

  3. Large area projection liquid-crystal video display system with inherent grid pattern optically removed

    NASA Technical Reports Server (NTRS)

    Liu, Hua-Kuang (Inventor)

    1992-01-01

    A relatively small and low-cost system is provided for projecting a large and bright television image onto a screen. A miniature liquid crystal array is driven by video circuitry to produce a pattern of transparencies in the array corresponding to a television image. Light is directed against the rear surface of the array to illuminate it, while a projection lens lies in front of the array to project the image of the array onto a large screen. Grid lines in the liquid crystal array are eliminated by a spacial filter which comprises a negative of the Fourier transform of the grid.

  4. How to Catch All Those Mutations—The Report of the Third Human Variome Project Meeting, UNESCO Paris, May 2010

    PubMed Central

    Kohonen-Corish, Maija R.J.; Al-Aama, Jumana Y.; Auerbach, Arleen D.; Axton, Myles; Barash, Carol Isaacson; Bernstein, Inge; Béroud, Christophe; Burn, John; Cunningham, Fiona; Cutting, Garry R.; den Dunnen, Johan T.; Greenblatt, Marc S.; Kaput, Jim; Katz, Michael; Lindblom, Annika; Macrae, Finlay; Maglott, Donna; Möslein, Gabriela; Povey, Sue; Ramesar, Raj; Richards, Sue; Seminara, Daniela; Sobrido, María-Jesús; Tavtigian, Sean; Taylor, Graham; Vihinen, Mauno; Winship, Ingrid; Cotton, Richard G.H.

    2011-01-01

    The third Human Variome Project (HVP) Meeting “Integration and Implementation” was held under UNESCO Patronage in Paris, France, at the UNESCO Headquarters May 10–14, 2010. The major aims of the HVP are the collection, curation, and distribution of all human genetic variation affecting health. The HVP has drawn together disparate groups, by country, gene of interest, and expertise, who are working for the common good with the shared goal of pushing the boundaries of the human variome and collaborating to avoid unnecessary duplication. The meeting addressed the 12 key areas that form the current framework of HVP activities: Ethics; Nomenclature and Standards; Publication, Credit and Incentives; Data Collection from Clinics; Overall Data Integration and Access—Peripheral Systems/Software; Data Collection from Laboratories; Assessment of Pathogenicity; Country Specific Collection; Translation to Healthcare and Personalized Medicine; Data Transfer, Databasing, and Curation; Overall Data Integration and Access—Central Systems; and Funding Mechanisms and Sustainability. In addition, three societies that support the goals and the mission of HVP also held their own Workshops with the view to advance disease-specific variation data collection and utilization: the International Society for Gastrointestinal Hereditary Tumours, the Micronutrient Genomics Project, and the Neurogenetics Consortium. PMID:20960468

  5. Effects of Neighborhood Consensus on Services Delivery. Human Services Bibliography Series. Project SHARE.

    ERIC Educational Resources Information Center

    Aspen Systems Corp., Germantown, MD.

    This Project SHARE bibliography lists 43 documents that are representative of the literature concerning the effects of neighborhood consensus on human services delivery. It is divided into three sections: abstracts, an alphabetical list of personal or corporate authors, and a title index. The abstracts are preceded by citation data to aid in…

  6. The Human Genome Project and Eugenics: Identifying the Impact on Individuals with Mental Retardation.

    ERIC Educational Resources Information Center

    Kuna, Jason

    2001-01-01

    This article explores the impact of the mapping work of the Human Genome Project on individuals with mental retardation and the negative effects of genetic testing. The potential to identify disabilities and the concept of eugenics are discussed, along with ethical issues surrounding potential genetic therapies. (Contains references.) (CR)

  7. Reflections on Mental Retardation and Eugenics, Old and New: Mensa and the Human Genome Project.

    ERIC Educational Resources Information Center

    Smith, J. David

    1994-01-01

    This article addresses the moral and ethical issues of mental retardation and a continuing legacy of belief in eugenics. It discusses the involuntary sterilization of Carrie Buck in 1927, support for legalized killing of subnormal infants by 47% of respondents to a Mensa survey, and implications of the Human Genome Project for the field of mental…

  8. From Mendel to the Human Genome Project: The Implications for Nurse Education.

    ERIC Educational Resources Information Center

    Burton, Hilary; Stewart, Alison

    2003-01-01

    The Human Genome Project is brining new opportunities to predict and prevent diseases. Although pediatric nurses are the closest to these developments, most nurses will encounter genetic aspects of practice and must understand the basic science and its ethical, legal, and social dimensions. (Includes commentary by Peter Birchenall.) (SK)

  9. Audio-Tutorial Project: An Audio-Tutorial Approach to Human Anatomy and Physiology.

    ERIC Educational Resources Information Center

    Muzio, Joseph N.; And Others

    A two course sequence on human anatomy and physiology using the audiotutorial method of instruction was developed for use by nursing students and other students in the health or medical fields at the Kingsborough Community College in New York. The project was motivated by the problems of often underprepared students coming to learn a new field and…

  10. Habitat for Humanity: La Grange, Georgia, 2003 Jimmy Carter Work Project

    SciTech Connect

    Not Available

    2005-06-01

    The Troup-Chambers Habitat for Humanity built a Habitat house to ENERGY STAR standards in LaGrange, Georgia, in 2003. The project was so successfully that all Troup-Chambers houses will now be built to ENERGY STAR standards.

  11. The Davideon Project: Capitalizing the Possibilities of Streaming Video as Flexible Learning Objects for the Humanities

    ERIC Educational Resources Information Center

    Rosendaal, Andre; Oomen, Johan

    2005-01-01

    Streaming video is a potentially revolutionary tool in humanities courses. The Davideon project, a large-scale effort conducted by the University of Groningen in conjunction with the University of Amsterdam, Windesheim University, and the Netherlands Institute for Sound and Vision, focused on integrating audiovisual materials into pedagogically…

  12. 2012 Groundwater Monitoring Report Project Shoal Area Subsurface Corrective Action Unit 447

    SciTech Connect

    2013-03-01

    The Project Shoal Area (PSA) in Nevada was the site of a 12-kiloton underground nuclear test in 1963. Although the surface of the site has been remediated, investigation of groundwater contamination resulting from the test is still in the corrective action process. Annual sampling and hydraulic head monitoring are conducted at the site as part of the subsurface corrective action strategy. Analytical results from the 2012 monitoring are consistent with those of the previous years, with tritium detected only in well HC-4. The tritium concentration in groundwater from well HC-4 remains far below the U.S. Environmental Protection Agency-established maximum contaminant level of 20,000 picocuries per liter. Concentrations of total uranium and gross alpha were also detected during this monitoring period, with uranium accounting for nearly all the gross alpha activity. The total uranium concentrations obtained from this monitoring period were consistent with previous results and reflect a slightly elevated natural uranium concentration, consistent with the mineralized geologic terrain. Isotopic ratios of uranium also indicate a natural source of uranium in groundwater, as opposed to a nuclear-test-related source. Water level trends obtained from the 2012 water level data were consistent with those of previous years. The corrective action strategy for the PSA is currently focused on revising the site conceptual model (SCM) and evaluating the adequacy of the current monitoring well network. Some aspects of the SCM are known; however, two major concerns are the uncertainty in the groundwater flow direction and the cause of rising water levels in site wells west of the shear zone. Water levels have been rising in the site wells west of the shear zone since the first hydrologic characterization wells were installed in 1996. While water levels in wells west of the shear zone continue to rise, the rate of increase is less than in previous years. The SCM will be revised, and an

  13. The demonstration projects: creating the capacity for nursing health human resource planning in Ontario's healthcare organizations.

    PubMed

    Burkoski, Vanessa; Tepper, Joshua

    2010-05-01

    Timely access to healthcare services requires the right number, mix and distribution of appropriately educated nurses, physicians and other healthcare professionals. In Ontario, as in several other jurisdictions, changing demographics, patterns of health service utilization and an aging workforce have created challenges related to the supply of nurses available now and in the future to deliver quality patient care. From 2006 to 2009, the Nursing Secretariat (NS) of Ontario's Ministry of Health and Long-Term Care (the ministry) undertook a progressive and comprehensive approach to address the issue of nursing supply across the province through the introduction of 17 Nursing Health Human Resources Demonstration Projects (demonstration projects). The demonstration projects initiative has led to the creation of a unique collection of best practices, tools and resources aimed at improving organizational planning capacity. Evaluation of the initiative generated recommendations that may guide the ministry toward policy and program development to foster improved nursing health human resource planning capacity in Ontario healthcare organizations.

  14. CADYRI, a dynamic mapping tool of human risk associated with flooding in urban areas

    NASA Astrophysics Data System (ADS)

    Tanguy, M.; Chokmani, K.; Bernier, M.; Poulin, J.

    2013-12-01

    When a flood affects an urban area, the managers and services responsible for public safety need precise and real time information on the localization of the flooded areas, on the submersion heights in those areas, but also on the vulnerability of people exposed to this hazard. Such information is essential for an effective crisis management. Despite a growing interest in this topic over the last 15 years, the development of flood risk assessment tools mainly focused on quantitative modeling of the monetary damages caused by floods to residential buildings or to critical infrastructures. Little attention was paid to the vulnerability of people exposed to flooding but also to the effects of the failure or destruction of critical infrastructures and residential building on people health and security during the disaster. Moreover, these models do not integrate the dynamic features of the flood (extent, submersion heights) and the evolution of human vulnerability in the same mapping tool. Thus, an accurate and precise evaluation of human risk induced by urban flooding is hardly feasible using such models. This study presents CADYRI, a dynamic mapping tool of human risk associated with flooding in urban areas, which fills the actual needs in terms of flood risk evaluation and management. This innovative tool integrates a methodology of flood hazard mapping that simulates, for a given discharge, the associated water level, and subsequently determines the extent of the flooded area and the submersion heights at each point of the flooded area, using a DEM. The dynamics of human vulnerability is then mapped at the household level, according to the characteristics of the flood hazard. Three key components of human vulnerability have been identified and are integrated to CADYRI: 1, the intrinsic vulnerability of the population, estimated by specific socio-economic indicators; 2, the vulnerability of buildings, assessed by their structural features; 3, the vulnerability of

  15. [An automatic extraction algorithm for individual tree crown projection area and volume based on 3D point cloud data].

    PubMed

    Xu, Wei-Heng; Feng, Zhong-Ke; Su, Zhi-Fang; Xu, Hui; Jiao, You-Quan; Deng, Ou

    2014-02-01

    Tree crown projection area and crown volume are the important parameters for the estimation of biomass, tridimensional green biomass and other forestry science applications. Using conventional measurements of tree crown projection area and crown volume will produce a large area of errors in the view of practical situations referring to complicated tree crown structures or different morphological characteristics. However, it is difficult to measure and validate their accuracy through conventional measurement methods. In view of practical problems which include complicated tree crown structure, different morphological characteristics, so as to implement the objective that tree crown projection and crown volume can be extracted by computer program automatically. This paper proposes an automatic untouched measurement based on terrestrial three-dimensional laser scanner named FARO Photon120 using plane scattered data point convex hull algorithm and slice segmentation and accumulation algorithm to calculate the tree crown projection area. It is exploited on VC+6.0 and Matlab7.0. The experiments are exploited on 22 common tree species of Beijing, China. The results show that the correlation coefficient of the crown projection between Av calculated by new method and conventional method A4 reaches 0.964 (p<0.01); and the correlation coefficient of tree crown volume between V(VC) derived from new method and V(C) by the formula of a regular body is 0.960 (p<0.001). The results also show that the average of V(C) is smaller than that of V(VC) at the rate of 8.03%, and the average of A4 is larger than that of A(V) at the rate of 25.5%. Assumed Av and V(VC) as ture values, the deviations of the new method could be attributed to irregularity of the crowns' silhouettes. Different morphological characteristics of tree crown led to measurement error in forest simple plot survey. Based on the results, the paper proposes that: (1) the use of eight-point or sixteen-point projection with

  16. The Human Placenta Project: placental structure, development, and function in real time.

    PubMed

    Guttmacher, A E; Maddox, Y T; Spong, C Y

    2014-05-01

    Despite its crucial role in the health of both the fetus and the pregnant woman, the placenta is the least understood human organ. Since a growing body of evidence also underscores the importance of placental development in the lifelong health of both mother and offspring, this lack of knowledge about placental structure and function is particularly concerning. Given modern approaches and technologies and the ability to develop new methods, we propose a coordinated "Human Placenta Project", with the ultimate goal of understanding human placental structure, development, and function in real time.

  17. NASA Human Health and Performance Center: Open innovation successes and collaborative projects

    NASA Astrophysics Data System (ADS)

    Richard, Elizabeth E.; Davis, Jeffrey R.

    2014-11-01

    In May 2007, what was then the Space Life Sciences Directorate published the 2007 Space Life Sciences Strategy for Human Space Exploration, setting the course for development and implementation of new business models and significant advances in external collaboration over the next five years. The strategy was updated on the basis of these accomplishments and reissued as the NASA Human Health and Performance Strategy in 2012, and continues to drive new approaches to innovation for the directorate. This short paper describes the successful execution of the strategy, driving organizational change through open innovation efforts and collaborative projects, including efforts of the NASA Human Health and Performance Center (NHHPC).

  18. Towards data management of the HUPO Human Brain Proteome Project pilot phase.

    PubMed

    Blüggel, Martin; Bailey, Sonja; Körting, Gerhard; Stephan, Christian; Reidegeld, Kai A; Thiele, Herbert; Apweiler, Rolf; Hamacher, Michael; Meyer, Helmut E

    2004-08-01

    The pilot phase of the Human Brain Proteome Project as a part of the Human Proteome Organisation has just been started. In two pilot studies, 18 different laboratories are analyzing mouse brains of three age stages and human brain autopsy versus biopsy material, respectively. The overall aim is to elucidate the portfolio of available techniques as well as to elaborate common standards. As a first step, it was decided to use the common bioinformatics platform ProteinScape that was introduced to the participating groups in a two day course in Bochum, Germany.

  19. Evaluation of dredged material proposed for ocean disposal from Red Hook/Bay Ridge project areas, New York

    SciTech Connect

    Pinza, M.R.; Barrows, E.S.; Borde, A.B.

    1996-09-01

    The objective of the Red HookIBay Ridge project was to evaluate proposed dredged material from these two areas to determine its suitability for unconfined ocean disposal at the Mud Dump Site. Sediment samples were collected from the Red Hook/Bay Ridge project areas. Tests and analyses were conducted. The evaluation of proposed dredged material from the Red Hook/Bay Ridge project areas consisted of bulk sediment chemical analyses, chemical analyses of dredging site water and elutriate, water-column and benthic acute toxicity tests. Twenty-four individual sediment core samples were collected from these two areas and analyzed for grain size, moisture content, and total organic carbon (TOC). Three composite sediment samples, representing Red Hook Channel and the two Bay Ridge Reaches to be dredged, were analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAH), and 1,4-dichlorobenzene. Dredging site water and elutriate water, which is prepared from the suspended-particulate phase (SPP) of the three Red Hook Bay Ridge sediment composites, were analyzed for metals, pesticides, and PCBS. Benthic acute toxicity tests were performed. Water-column or SPP toxicity tests were performed. Bioaccumulation tests were also conducted.

  20. L-325 Sagebrush Habitat Mitigation Project: FY2008 Compensation Area Monitoring Report

    SciTech Connect

    Durham, Robin E.; Sackschewsky, Michael R.

    2008-09-30

    This document provides a review and status of activities conducted in support of the Fluor Daniel Hanford Company (Fluor) Mitigation Action Plan (MAP) for Project L-325, Electrical Utility Upgrades. It includes time-zero monitoring results for planting activities conducted in January 2008, annual survival monitoring for all planting years (2007 and 2008), and recommendations for the successful completion of DOE habitat mitigation commitments for this project.

  1. Implementing transnational telemedicine solutions: a connected health project in rural and remote areas of six Northern Periphery countries Series on European collaborative projects.

    PubMed

    Casey, Monica; Hayes, Patrick S; Heaney, David; Dowie, Lee; Ólaighin, Gearoid; Matero, Matti; Hun, Soo; Knarvik, Undine; Alrutz, Käte; Eadie, Leila; Glynn, Liam G

    2013-03-01

    This is the first article in a Series on collaborative projects between European countries, relevant for general practice/family medicine and primary healthcare. Telemedicine, in particular the use of the Internet, videoconferencing and handheld devices such as smartphones, holds the potential for further strides in the application of technology for the delivery of healthcare, particularly to communities in rural and remote areas within and without the European Union where this study is taking place. The Northern Periphery Programme has funded the 'Implementing Transnational Telemedicine Solutions' (ITTS) project from September 2011 to December 2013, led by the Centre for Rural Health in Inverness, Scotland. Ten sustainable projects based on videoconsultation (speech therapy, renal services, emergency psychiatry, diabetes), mobile patient self-management (physical activity, diabetes, inflammatory bowel disease) and home-based health services (medical and social care emergencies, rehabilitation, multi-morbidity) are being implemented by the six partner countries: Scotland, Finland, Ireland, Northern Ireland, Norway and Sweden. In addition, an International Telemedicine Advisory Service, created for the project, provides business expertise and advice. Community panels contribute feedback on the design and implementation of services and ensure 'user friendliness'. The project goals are to improve accessibility of healthcare in rural and remote communities, reducing unnecessary hospital visits and travel in a sustainable way. Opportunities will be provided for comparative research studies. This article provides an introduction to the ITTS project and how it aims to fulfil these needs. The ITTS team encourage all healthcare providers to at least explore possible technological solutions within their own context.

  2. The implementation of the Human Exploration Demonstration Project (HEDP), a systems technology testbed

    NASA Technical Reports Server (NTRS)

    Rosen, Robert; Korsmeyer, David J.

    1993-01-01

    The Human Exploration Demonstration Project (HEDP) is an ongoing task at the NASA's Ames Research Center to address the advanced technology requirements necessary to implement an integrated working and living environment for a planetary surface habitat. The integrated environment consists of life support systems, physiological monitoring of project crew, a virtual environment work station, and centralized data acquisition and habitat systems health monitoring. The HEDP is an integrated technology demonstrator, as well as an initial operational testbed. There are several robotic systems operational in a simulated planetary landscape external to the habitat environment, to provide representative work loads for the crew. This paper describes the evolution of the HEDP from initial concept to operational project; the status of the HEDP after two years; the final facilities composing the HEDP; the project's role as a NASA Ames Research Center systems technology testbed; and the interim demonstration scenarios that have been run to feature the developing technologies in 1993.

  3. Brain Response to a Humanoid Robot in Areas Implicated in the Perception of Human Emotional Gestures

    PubMed Central

    Chaminade, Thierry; Zecca, Massimiliano; Blakemore, Sarah-Jayne; Takanishi, Atsuo; Frith, Chris D.; Micera, Silvestro; Dario, Paolo; Rizzolatti, Giacomo; Gallese, Vittorio; Umiltà, Maria Alessandra

    2010-01-01

    Background The humanoid robot WE4-RII was designed to express human emotions in order to improve human-robot interaction. We can read the emotions depicted in its gestures, yet might utilize different neural processes than those used for reading the emotions in human agents. Methodology Here, fMRI was used to assess how brain areas activated by the perception of human basic emotions (facial expression of Anger, Joy, Disgust) and silent speech respond to a humanoid robot impersonating the same emotions, while participants were instructed to attend either to the emotion or to the motion depicted. Principal Findings Increased responses to robot compared to human stimuli in the occipital and posterior temporal cortices suggest additional visual processing when perceiving a mechanical anthropomorphic agent. In contrast, activity in cortical areas endowed with mirror properties, like left Broca's area for the perception of speech, and in the processing of emotions like the left anterior insula for the perception of disgust and the orbitofrontal cortex for the perception of anger, is reduced for robot stimuli, suggesting lesser resonance with the mechanical agent. Finally, instructions to explicitly attend to the emotion significantly increased response to robot, but not human facial expressions in the anterior part of the left inferior frontal gyrus, a neural marker of motor resonance. Conclusions Motor resonance towards a humanoid robot, but not a human, display of facial emotion is increased when attention is directed towards judging emotions. Significance Artificial agents can be used to assess how factors like anthropomorphism affect neural response to the perception of human actions. PMID:20657777

  4. Real-Time Estimation of Small-Area Populations with Human Biomarkers in Sewage

    EPA Science Inventory

    A totally new approach is conceptualized for measuring small-area human populations by using biomarkers in sewage. The basis for the concept (SCIM: Sewage Chemical-Information Mining) is supported by a comprehensive examination and synthesis of data published across several disc...

  5. Cortical surface area and cortical thickness demonstrate differential structural asymmetry in auditory-related areas of the human cortex.

    PubMed

    Meyer, Martin; Liem, Franziskus; Hirsiger, Sarah; Jäncke, Lutz; Hänggi, Jürgen

    2014-10-01

    This investigation provides an analysis of structural asymmetries in 5 anatomically defined regions (Heschl's gyrus, HG; Heschl's sulcus, HS; planum temporale, PT; planum polare, PP; superior temporal gyrus, STG) within the human auditory-related cortex. Volumetric 3-dimensional T1-weighted magnetic resonance imaging scans were collected from 104 participants (52 males). Cortical volume (CV), cortical thickness (CT), and cortical surface area (CSA) were calculated based on individual scans of these anatomical traits. This investigation demonstrates a leftward asymmetry for CV and CSA that is observed in the HG, STG, and PT regions. As regards CT, we note a rightward asymmetry in the HG and HS. A correlation analysis of asymmetry indices between measurements for distinct regions of interest (ROIs) yields significant correlations between CT and CV in 4 of 5 ROIs (HG, HS, PT, and STG). Significant correlation values between CSA and CV are observed for all 5 ROIs. The findings suggest that auditory-related cortical areas demonstrate larger leftward asymmetry with respect to the CSA, while a clear rightward asymmetry with respect to CT is salient in both the primary and the secondary auditory cortex only. In addition, we propose that CV is not an ideal neuromarker for anatomical measurements. CT and CSA should be considered independent traits of anatomical asymmetries in the auditory-related cortex.

  6. A brief review on the Human Encyclopedia of DNA Elements (ENCODE) project.

    PubMed

    Qu, Hongzhu; Fang, Xiangdong

    2013-06-01

    The ENCyclopedia Of DNA Elements (ENCODE) project is an international research consortium that aims to identify all functional elements in the human genome sequence. The second phase of the project comprised 1640 datasets from 147 different cell types, yielding a set of 30 publications across several journals. These data revealed that 80.4% of the human genome displays some functionality in at least one cell type. Many of these regulatory elements are physically associated with one another and further form a network or three-dimensional conformation to affect gene expression. These elements are also related to sequence variants associated with diseases or traits. All these findings provide us new insights into the organization and regulation of genes and genome, and serve as an expansive resource for understanding human health and disease.

  7. Inside SMP proteomics: six years German Human Brain Proteome Project (HBPP) - a summary.

    PubMed

    Hamacher, Michael; Hardt, Tanja; van Hall, Andre; Stephan, Christian; Marcus, Katrin; Meyer, Helmut E

    2008-03-01

    In 2001, the German Federal Ministry of Education and Research (BMBF) initiated the National Genome Research Network (NGFN; www.ngfn.de) as a nation-wide multidisciplinary networking platform aiming at the analysis of common human diseases and aging. Within the NGFN the Human Brain Proteome Project (HBPP; www.smp-proteomics.de) focuses on the analysis of the human brain in health and disease. The concept is based on two consecutive steps: (i) Elaborating and establishing the necessary technology platforms. (ii) Application of the established technologies for research in Alzheimer's disease and Parkinson's disease. In the first funding period, HBPP1, running from 2001 to 2004, necessary technologies were established and optimized. In HBPP2, which started 2004 and will end in May 2008, the developed technologies are used for large-scale experiments, offering new links for disease related research and therapies. The following overview describes structure, aims and outcome of this unique German Brain Proteome Project.

  8. The Human and Physical Determinants of Wildfires and Burnt Areas in Israel.

    PubMed

    Levin, Noam; Tessler, Naama; Smith, Andrew; McAlpine, Clive

    2016-09-01

    Wildfires are expected to increase in Mediterranean landscapes as a result of climate change and changes in land-use practices. In order to advance our understanding of human and physical factors shaping spatial patterns of wildfires in the region, we compared two independently generated datasets of wildfires for Israel that cover approximately the same study period. We generated a site-based dataset containing the location of 10,879 wildfires (1991-2011), and compared it to a dataset of burnt areas derived from MODIS imagery (2000-2011). We hypothesized that the physical and human factors explaining the spatial distribution of burnt areas derived from remote sensing (mostly large fires, >100 ha) will differ from those explaining site-based wildfires recorded by national agencies (mostly small fires, <10 ha). Small wildfires recorded by forestry agencies were concentrated within planted forests and near built-up areas, whereas the largest wildfires were located in more remote regions, often associated with military training areas and herbaceous vegetation. We conclude that to better understand wildfire dynamics, consolidation of wildfire databases should be achieved, combining field reports and remote sensing. As nearly all wildfires in Mediterranean landscapes are caused by human activities, improving the management of forest areas and raising public awareness to fire risk are key considerations in reducing fire danger.

  9. The Human and Physical Determinants of Wildfires and Burnt Areas in Israel

    NASA Astrophysics Data System (ADS)

    Levin, Noam; Tessler, Naama; Smith, Andrew; McAlpine, Clive

    2016-09-01

    Wildfires are expected to increase in Mediterranean landscapes as a result of climate change and changes in land-use practices. In order to advance our understanding of human and physical factors shaping spatial patterns of wildfires in the region, we compared two independently generated datasets of wildfires for Israel that cover approximately the same study period. We generated a site-based dataset containing the location of 10,879 wildfires (1991-2011), and compared it to a dataset of burnt areas derived from MODIS imagery (2000-2011). We hypothesized that the physical and human factors explaining the spatial distribution of burnt areas derived from remote sensing (mostly large fires, >100 ha) will differ from those explaining site-based wildfires recorded by national agencies (mostly small fires, <10 ha). Small wildfires recorded by forestry agencies were concentrated within planted forests and near built-up areas, whereas the largest wildfires were located in more remote regions, often associated with military training areas and herbaceous vegetation. We conclude that to better understand wildfire dynamics, consolidation of wildfire databases should be achieved, combining field reports and remote sensing. As nearly all wildfires in Mediterranean landscapes are caused by human activities, improving the management of forest areas and raising public awareness to fire risk are key considerations in reducing fire danger.

  10. Role of Demographic Dynamics and Conflict in the Population-Area Relationship for Human Languages

    PubMed Central

    Manrubia, Susanna C.; Axelsen, Jacob B.; Zanette, Damián H.

    2012-01-01

    Many patterns displayed by the distribution of human linguistic groups are similar to the ecological organization described for biological species. It remains a challenge to identify simple and meaningful processes that describe these patterns. The population size distribution of human linguistic groups, for example, is well fitted by a log-normal distribution that may arise from stochastic demographic processes. As we show in this contribution, the distribution of the area size of home ranges of those groups also agrees with a log-normal function. Further, size and area are significantly correlated: the number of speakers and the area spanned by linguistic groups follow the allometric relation , with an exponent varying accross different world regions. The empirical evidence presented leads to the hypothesis that the distributions of and , and their mutual dependence, rely on demographic dynamics and on the result of conflicts over territory due to group growth. To substantiate this point, we introduce a two-variable stochastic multiplicative model whose analytical solution recovers the empirical observations. Applied to different world regions, the model reveals that the retreat in home range is sublinear with respect to the decrease in population size, and that the population-area exponent grows with the typical strength of conflicts. While the shape of the population size and area distributions, and their allometric relation, seem unavoidable outcomes of demography and inter-group contact, the precise value of could give insight on the cultural organization of those human groups in the last thousand years. PMID:22815726

  11. Human detection in sensitive security areas through recognition of omega shapes using MACH filters

    NASA Astrophysics Data System (ADS)

    Rehman, Saad; Riaz, Farhan; Hassan, Ali; Liaquat, Muwahida; Young, Rupert

    2015-03-01

    Human detection has gained considerable importance in aggravated security scenarios over recent times. An effective security application relies strongly on detailed information regarding the scene under consideration. A larger accumulation of humans than the number of personal authorized to visit a security controlled area must be effectively detected, amicably alarmed and immediately monitored. A framework involving a novel combination of some existing techniques allows an immediate detection of an undesirable crowd in a region under observation. Frame differencing provides a clear visibility of moving objects while highlighting those objects in each frame acquired by a real time camera. Training of a correlation pattern recognition based filter on desired shapes such as elliptical representations of human faces (variants of an Omega Shape) yields correct detections. The inherent ability of correlation pattern recognition filters caters for angular rotations in the target object and renders decision regarding the existence of the number of persons exceeding an allowed figure in the monitored area.

  12. Well Completion Report for Corrective Action Unit 447, Project Shoal Area, Churchill County, Nevada, Rev. No.: 0

    SciTech Connect

    Rick Findlay

    2006-09-01

    This Well Completion Report is being provided as part of the implementation of the Corrective Action Decision Document (CADD)/Corrective Action Plan (CAP) for Corrective Action Unit (CAU) 447 (NNSA/NSO, 2006a). The CADD/CAP is part of an ongoing U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (NNSA/NSO) funded project for the investigation of CAU 447 at the Project Shoal Area (PSA). All work performed on this project was conducted in accordance with the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996), and all applicable Nevada Division of Environmental Protection (NDEP) policies and regulations. Investigation activities included the drilling, construction, and development of three monitoring/validation (MV) wells at the PSA. This report summarizes the field activities and data collected during the investigation.

  13. Simulation of five ground-water withdrawal projections for the Black Mesa area, Navajo and Hopi Indian Reservations, Arizona

    USGS Publications Warehouse

    Brown, J.G.; Eychaner, J.H.

    1988-01-01

    The N Aquifer is the main source of water in the 5,400 sq mi Black Mesa area in the Navajo and Hopi Indian Reservations in northeastern Arizona. Water in the aquifer is under confined conditions in the central 3,300 sq mi of the area. Maximum saturated thickness is about 1,050 ft. Annual groundwater withdrawals from 1972 through 1986 averaged 5,480 acre-ft and included 3,820 acre-ft used to operate a coal mine on Black Mesa. As a result, water levels have declined in a large part of the aquifer. The coal company has applied for a permanent permit under the Surface Mining Control and Reclamation Act of 1977. An existing mathematical model of the aquifer in the Black Mesa area was converted to a newer model program and recalibrated by using revised estimates of selected aquifer parameters and a finer spatial grid. The model was used to simulate four groundwater withdrawal alternatives that combined the existing and proposed mining plans with projected constant or increasing pumpage for nearby communities. A fifth alternative combined increasing community pumpage with no mine withdrawals and was used as a basis for comparison. Simulated water levels for the year 2031 in the coal-lease area are projected to be 60 ft lower than in 1985 for the proposed mining plan combined with growing community pumpage and > 100 ft lower than predevelopment water levels over an area of 1,660 sq mi. Groundwater would rise to within 100 ft of predevelopment levels < 10 yr after mine withdrawals cease. Withdrawals at the mine were a minor factor in determining simulated water levels at most communities in the study area. Water levels at Tuba City were not affected by mine pumpage in any projection. (Author 's abstract)

  14. The Integrative Human Microbiome Project: dynamic analysis of microbiome-host omics profiles during periods of human health and disease.

    PubMed

    2014-09-10

    Much has been learned about the diversity and distribution of human-associated microbial communities, but we still know little about the biology of the microbiome, how it interacts with the host, and how the host responds to its resident microbiota. The Integrative Human Microbiome Project (iHMP, http://hmp2.org), the second phase of the NIH Human Microbiome Project, will study these interactions by analyzing microbiome and host activities in longitudinal studies of disease-specific cohorts and by creating integrated data sets of microbiome and host functional properties. These data sets will serve as experimental test beds to evaluate new models, methods, and analyses on the interactions of host and microbiome. Here we describe the three models of microbiome-associated human conditions, on the dynamics of preterm birth, inflammatory bowel disease, and type 2 diabetes, and their underlying hypotheses, as well as the multi-omic data types to be collected, integrated, and distributed through public repositories as a community resource.

  15. Ventromedial mesencephalic tegmental (VMT) projections to ten functionally different cortical areas in the cat: topography and quantitative analysis.

    PubMed

    Scheibner, T; Törk, I

    1987-05-08

    The cortical projections of the ventromedial mesencephalic tegmentum (VMT) were studied in the cat by the retrograde transport of wheat germ agglutinin-conjugated HRP (WGA-HRP). The following cortical regions were injected: prefrontal, cingulate, motor, somatic sensory, auditory, primary visual, secondary visual, parasplenial, insular, and entorhinal. Labelled cells in the five component nuclei of the VMT (rostral linear, parabrachial pigmented, central linear, interfascicular, and paranigral nuclei) were counted and the numbers correlated with the total cell populations of the nuclei. In all experiments large numbers of cells were labelled in the VMT, particularly in the rostral linear and parabrachial pigmented nuclei. Following entorhinal cortical injections, significant labelling occurred in the interfascicular and central linear nucleus, although some cells of these nuclei were labelled in every experiment. The cells of the paranigral nucleus remained unlabelled in all experiments. Several hundred VMT cells were labelled in most experiments, over 1000 in the case of the parasplenial and over 2000 in the case of prefrontal injections. The most strongly labelled nucleus was the rostral linear, in which up to 36% of the total cell population could be labelled in a single experiment. These results indicate that the VMT of the cat is a major source of brainstem projections to the cerebral cortex and that all cortical areas are reached by this system. Although the projections to the prefrontal and limbic cortical areas are particularly prominent, there appears to be a consistent and significant projection to all areas. Further, the projection of the VMT to the cortex is topographically organized, indicating that the functional roles of the component nuclei of the VMT may be substantially different.

  16. Economic evaluations of four GRI (Gas Research Institute) unconventional-gas project areas. Annual report, September 1982-June 1983

    SciTech Connect

    Haas, S.M.; Marshalla, R.A.; Nesbitt, D.M.; Oman, D.B.

    1983-01-01

    Analysis shows that the value of economic benefit (measured at a five percent discount rate) specifically attributable to each of GRI's four unconventional gas research areas is computed as: western tight gas sands, 18 billion dollars; eastern Devonian gas shales, 5 billion dollars; methane from coal deposits, 8.6 billion dollars; and geopressured aquifers, zero (not likely to penetrate the market). The economic benefits calculation reflects the cost of fuel displaced relative to the cost of the gas provided. The magnitudes of economic benefits for these project areas far exceed the annual research budget for unconventional gas at GRI.

  17. L-325 Sagebrush Habitat Mitigation Project: FY2009 Compensation Area Monitoring Report

    SciTech Connect

    Durham, Robin E.; Sackschewsky, Michael R.

    2009-09-29

    Annual monitoring in support of the Fluor Daniel Hanford Company (Fluor) Mitigation Action Plan (MAP) for Project L-325, Electrical Utility Upgrades was conducted in June 2009. MAP guidelines defined mitigation success for this project as 3000 established sagebrush transplants on a 4.5 ha mitigation site after five monitoring years. Annual monitoring results suggest that an estimated 2130 sagebrush transplants currently grow on the site. Additional activities in support of this project included gathering sagebrush seed and securing a local grower to produce between 2250 and 2500 10-in3 tublings for outplanting during the early winter months of FY2010. If the minimum number of seedlings grown for this planting meets quality specifications, and planting conditions are favorable, conservative survival estimates indicate the habitat mitigation goals outlined in the MAP will be met in FY2014.

  18. Irrigated rice area estimation using remote sensing techniques: Project's proposal and preliminary results. [Rio Grande do Sul, Brazil

    NASA Technical Reports Server (NTRS)

    Parada, N. D. J. (Principal Investigator); Deassuncao, G. V.; Moreira, M. A.; Novaes, R. A.

    1984-01-01

    The development of a methodology for annual estimates of irrigated rice crop in the State of Rio Grande do Sul, Brazil, using remote sensing techniques is proposed. The project involves interpretation, digital analysis, and sampling techniques of LANDSAT imagery. Results are discussed from a preliminary phase for identifying and evaluating irrigated rice crop areas in four counties of the State, for the crop year 1982/1983. This first phase involved just visual interpretation techniques of MSS/LANDSAT images.

  19. The Drumchapel Project: A Study of ICT Usage by School Pupils and Teachers in a Secondary School in a Deprived Area of Glasgow

    ERIC Educational Resources Information Center

    McLelland, Dorothy; Crawford, John

    2004-01-01

    The Drumchapel Project was a joint exploratory project between Glasgow Caledonian University, a 1992 university, and Drumchapel High School, a secondary school in a deprived area of Glasgow. The initial aim was to explore ICT skill levels among the school pupils but an information literacy agenda emerged in the course of the Project. Focus groups…

  20. Comprehensive genome-wide proteomic analysis of human placental tissue for the Chromosome-Centric Human Proteome Project.

    PubMed

    Lee, Hyoung-Joo; Jeong, Seul-Ki; Na, Keun; Lee, Min Jung; Lee, Sun Hee; Lim, Jong-Sun; Cha, Hyun-Jeong; Cho, Jin-Young; Kwon, Ja-Young; Kim, Hoguen; Song, Si Young; Yoo, Jong Shin; Park, Young Mok; Kim, Hail; Hancock, William S; Paik, Young-Ki

    2013-06-07

    As a starting point of the Chromosome-Centric Human Proteome Project (C-HPP), we established strategies of genome-wide proteomic analysis, including protein identification, quantitation of disease-specific proteins, and assessment of post-translational modifications, using paired human placental tissues from healthy and preeclampsia patients. This analysis resulted in identification of 4239 unique proteins with high confidence (two or more unique peptides with a false discovery rate less than 1%), covering 21% of approximately 20, 059 (Ensembl v69, Oct 2012) human proteins, among which 28 proteins exhibited differentially expressed preeclampsia-specific proteins. When these proteins are assigned to all human chromosomes, the pattern of the newly identified placental protein population is proportional to that of the gene count distribution of each chromosome. We also identified 219 unique N-linked glycopeptides, 592 unique phosphopeptides, and 66 chromosome 13-specific proteins. In particular, protein evidence of 14 genes previously known to be specifically up-regulated in human placenta was verified by mass spectrometry. With respect to the functional implication of these proteins, 38 proteins were found to be involved in regulatory factor biosynthesis or the immune system in the placenta, but the molecular mechanism of these proteins during pregnancy warrants further investigation. As far as we know, this work produced the highest number of proteins identified in the placenta and will be useful for annotating and mapping all proteins encoded in the human genome.

  1. Photoreceptor projections and receptive fields in the dorsal rim area and main retina of the locust eye.

    PubMed

    Schmeling, Fabian; Tegtmeier, Jennifer; Kinoshita, Michiyo; Homberg, Uwe

    2015-05-01

    In many insect species, photoreceptors of a small dorsal rim area of the eye are specialized for sensitivity to the oscillation plane of polarized skylight and, thus, serve a role in sky compass orientation. To further understand peripheral mechanisms of polarized-light processing in the optic lobe, we have studied the projections of photoreceptors and their receptive fields in the main eye and dorsal rim area of the desert locust, a model system for polarization vision analysis. In both eye regions, one photoreceptor per ommatidium, R7, has a long visual fiber projecting through the lamina to the medulla. Axonal fibers from R7 receptors of the dorsal rim area have short side branches throughout the depth of the dorsal lamina and maintain retinotopic projections to the dorsal medulla following the first optic chiasma. Receptive fields of dorsal rim photoreceptors are considerably larger (average acceptance angle 33°) than those of the main eye (average acceptance angle 2.04°) and, taken together, cover almost the entire sky. The data challenge previous reports of two long visual fibers per ommatidium in the main eye of the locust and provide data for future analysis of peripheral networks underlying polarization opponency in the locust brain.

  2. High resolution climate projections to assess the future vulnerability of European urban areas to climatological extreme events

    NASA Astrophysics Data System (ADS)

    Fallmann, Joachim; Wagner, Sven; Emeis, Stefan

    2017-02-01

    Results from high resolution 7-km WRF regional climate model (RCM) simulations are used to analyse changes in the occurrence frequencies of heat waves, of precipitation extremes and of the duration of the winter time freezing period for highly populated urban areas in Central Europe. The projected climate change impact is assessed for 11 urban areas based on climate indices for a future period (2021-2050) compared to a reference period (1971-2000) using the IPCC AR4 A1B Scenario as boundary conditions. These climate indices are calculated from daily maximum, minimum and mean temperatures as well as precipitation amounts. By this, the vulnerability of these areas to future climate conditions is to be investigated. The number of heat waves, as well as the number of single hot days, tropical nights and heavy precipitation events is projected to increase in the near future. In addition, the number of frost days is significantly decreased. Probability density functions of monthly mean summer time temperatures show an increase of the 95th percentile of about 1-3 °C for the future compared with the reference period. The projected increase of cooling and decrease of heating degree days indicate the possible impact on urban energy consumption under future climate conditions.

  3. The Human Genome Project and Mental Retardation: An Educational Program. Final Progress Report

    SciTech Connect

    Davis, Sharon

    1999-05-03

    The Arc, a national organization on mental retardation, conducted an educational program for members, many of whom have a family member with a genetic condition causing mental retardation. The project informed members about the Human Genome scientific efforts, conducted training regarding ethical, legal and social implications and involved members in issue discussions. Short reports and fact sheets on genetic and ELSI topics were disseminated to 2,200 of the Arc's leaders across the country and to other interested individuals. Materials produced by the project can e found on the Arc's web site, TheArc.org.

  4. The Human Phenotype Ontology project: linking molecular biology and disease through phenotype data.

    PubMed

    Köhler, Sebastian; Doelken, Sandra C; Mungall, Christopher J; Bauer, Sebastian; Firth, Helen V; Bailleul-Forestier, Isabelle; Black, Graeme C M; Brown, Danielle L; Brudno, Michael; Campbell, Jennifer; FitzPatrick, David R; Eppig, Janan T; Jackson, Andrew P; Freson, Kathleen; Girdea, Marta; Helbig, Ingo; Hurst, Jane A; Jähn, Johanna; Jackson, Laird G; Kelly, Anne M; Ledbetter, David H; Mansour, Sahar; Martin, Christa L; Moss, Celia; Mumford, Andrew; Ouwehand, Willem H; Park, Soo-Mi; Riggs, Erin Rooney; Scott, Richard H; Sisodiya, Sanjay; Van Vooren, Steven; Wapner, Ronald J; Wilkie, Andrew O M; Wright, Caroline F; Vulto-van Silfhout, Anneke T; de Leeuw, Nicole; de Vries, Bert B A; Washingthon, Nicole L; Smith, Cynthia L; Westerfield, Monte; Schofield, Paul; Ruef, Barbara J; Gkoutos, Georgios V; Haendel, Melissa; Smedley, Damian; Lewis, Suzanna E; Robinson, Peter N

    2014-01-01

    The Human Phenotype Ontology (HPO) project, available at http://www.human-phenotype-ontology.org, provides a structured, comprehensive and well-defined set of 10,088 classes (terms) describing human phenotypic abnormalities and 13,326 subclass relations between the HPO classes. In addition we have developed logical definitions for 46% of all HPO classes using terms from ontologies for anatomy, cell types, function, embryology, pathology and other domains. This allows interoperability with several resources, especially those containing phenotype information on model organisms such as mouse and zebrafish. Here we describe the updated HPO database, which provides annotations of 7,278 human hereditary syndromes listed in OMIM, Orphanet and DECIPHER to classes of the HPO. Various meta-attributes such as frequency, references and negations are associated with each annotation. Several large-scale projects worldwide utilize the HPO for describing phenotype information in their datasets. We have therefore generated equivalence mappings to other phenotype vocabularies such as LDDB, Orphanet, MedDRA, UMLS and phenoDB, allowing integration of existing datasets and interoperability with multiple biomedical resources. We have created various ways to access the HPO database content using flat files, a MySQL database, and Web-based tools. All data and documentation on the HPO project can be found online.

  5. The Human Phenotype Ontology project: linking molecular biology and disease through phenotype data

    PubMed Central

    Köhler, Sebastian; Doelken, Sandra C.; Mungall, Christopher J.; Bauer, Sebastian; Firth, Helen V.; Bailleul-Forestier, Isabelle; Black, Graeme C. M.; Brown, Danielle L.; Brudno, Michael; Campbell, Jennifer; FitzPatrick, David R.; Eppig, Janan T.; Jackson, Andrew P.; Freson, Kathleen; Girdea, Marta; Helbig, Ingo; Hurst, Jane A.; Jähn, Johanna; Jackson, Laird G.; Kelly, Anne M.; Ledbetter, David H.; Mansour, Sahar; Martin, Christa L.; Moss, Celia; Mumford, Andrew; Ouwehand, Willem H.; Park, Soo-Mi; Riggs, Erin Rooney; Scott, Richard H.; Sisodiya, Sanjay; Vooren, Steven Van; Wapner, Ronald J.; Wilkie, Andrew O. M.; Wright, Caroline F.; Vulto-van Silfhout, Anneke T.; de Leeuw, Nicole; de Vries, Bert B. A.; Washingthon, Nicole L.; Smith, Cynthia L.; Westerfield, Monte; Schofield, Paul; Ruef, Barbara J.; Gkoutos, Georgios V.; Haendel, Melissa; Smedley, Damian; Lewis, Suzanna E.; Robinson, Peter N.

    2014-01-01

    The Human Phenotype Ontology (HPO) project, available at http://www.human-phenotype-ontology.org, provides a structured, comprehensive and well-defined set of 10,088 classes (terms) describing human phenotypic abnormalities and 13,326 subclass relations between the HPO classes. In addition we have developed logical definitions for 46% of all HPO classes using terms from ontologies for anatomy, cell types, function, embryology, pathology and other domains. This allows interoperability with several resources, especially those containing phenotype information on model organisms such as mouse and zebrafish. Here we describe the updated HPO database, which provides annotations of 7,278 human hereditary syndromes listed in OMIM, Orphanet and DECIPHER to classes of the HPO. Various meta-attributes such as frequency, references and negations are associated with each annotation. Several large-scale projects worldwide utilize the HPO for describing phenotype information in their datasets. We have therefore generated equivalence mappings to other phenotype vocabularies such as LDDB, Orphanet, MedDRA, UMLS and phenoDB, allowing integration of existing datasets and interoperability with multiple biomedical resources. We have created various ways to access the HPO database content using flat files, a MySQL database, and Web-based tools. All data and documentation on the HPO project can be found online. PMID:24217912

  6. The Content Area Reading Project: An Inservice Education Program for Junior High School Teachers and Teachers of Adults. Appendix C, Model Teaching Materials. Final Report.

    ERIC Educational Resources Information Center

    Dupuis, Mary M.; Askov, Eunice N.

    Materials developed by teacher participants in the Content Area Reading Project are presented in this appendix to the Project report. The first section provides group informal reading inventories developed for use in adult education, teaching English as a second language, and nine content areas; it then presents cloze tests developed for use in…

  7. Integrated Project Management: A Case Study in Integrating Cost, Schedule, Technical, and Risk Areas

    NASA Technical Reports Server (NTRS)

    Smith, Greg

    2004-01-01

    This viewgraph presentation describes a case study as a model for integrated project management. The ISS Program Office (ISSPO) developed replacement fluid filtration cartridges in house for the International Space Station (ISS). The presentation includes a step-by-step procedure and organizational charts for how the fluid filtration problem was approached.

  8. Using Interdisciplinary, Project-Based, Multimodal Activities to Facilitate Literacy across the Content Areas

    ERIC Educational Resources Information Center

    Hill, Archie E.

    2014-01-01

    Tour Across America is an interdisciplinary, project-based, multimodal (IPM) activity where students get the opportunity to apply what they learn to a real-life situation while illustrating the interdisciplinary nature of literacy. It provides students with a high-interest, creative platform to review, reinforce, and integrate learned literacy…

  9. School Age Multihandicapped Project: Capital Area Rehabilitation Center. Final Report 1977-1980.

    ERIC Educational Resources Information Center

    Capital Area Rehabilitation Center, Austin, TX.

    The document contains the final report of a model project to provide a therapeutically based educational program for severely handicapped, orthopedically impaired children (6 to 21 years old) utilizing the skills of teachers, aides, therapists, and a nurse to provide individualized hands on services. Section I contains an overview of the…

  10. Human dimension in scientific models in high-mountain climate change and risk projects: Peruvian-Swiss experiences

    NASA Astrophysics Data System (ADS)

    Vicuña, Luis; Jurt, Christine; Minan, Fiorella; Huggel, Christian

    2014-05-01

    Models in a range of scientific disciplines are increasingly seen as indispensable for successful adaptation. Governments as well as international organizations and cooperations put their efforts in basing their adaptation projects on scientific results. Thereby, it is critical that scientific models are first put into the particular context in which they will be applied. This paper addresses the experience of the project 'Glaciers 513- Climate change adaptation and disaster risk management for glacier retreat in the Andes' conducted in the districts of Carhuaz (Ancash region) and Santa Teresa (Cusco region) in Peru. The Peruvian and the Swiss governments put their joint efforts in an adaptation project in the context of climate change and the retreat of the glaciers. The project is led by a consortium of Care Peru and the University of Zurich with additional Swiss partners and its principal aim is to improve the capacity for integral adaptation and reduce the risk of disasters from glaciers and high-mountain areas, and effects of climate change, particularly in the regions of Cusco and Ancash. The paper shows how the so called "human dimension" on the one hand, and models from a range of disciplines, including climatology, glaciology, and hydrology on the other hand, were conceptualized and perceived by the different actors involved in the project. Important aspects have been, among others, the role of local knowledge including ancestral knowledge, demographic information, socio-economic indicators as well as the social, political and cultural framework and the historical background. Here we analyze the role and context of local knowledge and the historical background. The analysis of the implications of the differences and similarities of the perceptions of a range of actors contributes to the discussion about how, and to what extent scientific models can be contextualized, what kind of information can be helpful for the contextualization and how it can be

  11. Projected changes in wildlife habitats in Arctic natural areas of northwest Alaska

    USGS Publications Warehouse

    Marcot, Bruce G.; Jorgenson, M. Torre; Lawler, James P.; Handel, Colleen M.; DeGange, Anthony R.

    2015-01-01

    We project the effects of transitional changes among 60 vegetation and other land cover types (“ecotypes”) in northwest Alaska over the 21st century on habitats of 162 bird and 39 mammal species known or expected to occur regularly in the region. This analysis, encompassing a broad suite of arctic and boreal wildlife species, entailed building wildlife-habitat matrices denoting levels of use of each ecotype by each species, and projecting habitat changes under historic and expected accelerated future rates of change from increasing mean annual air temperature based on the average of 5 global climate models under the A1B emissions scenario, and from potential influence of a set of 23 biophysical drivers. Under historic rates of change, we project that 52 % of the 201 species will experience an increase in medium- and high-use habitats, 3 % no change, and 45 % a decrease, and that a greater proportion of mammal species (62 %) will experience habitat declines than will bird species (50 %). Outcomes become more dire (more species showing habitat loss) under projections made from effects of biophysical drivers and especially from increasing temperature, although species generally associated with increasing shrub and tree ecotypes will likely increase in distribution. Changes in wildlife habitats likely will also affect trophic cascades, ecosystem function, and ecosystem services; of particular significance are the projected declines in habitats of most small mammals that form the prey base for mesocarnivores and raptors, and habitat declines in 25 of the 50 bird and mammal species used for subsistence hunting and trapping.

  12. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project.

    PubMed

    Birney, Ewan; Stamatoyannopoulos, John A; Dutta, Anindya; Guigó, Roderic; Gingeras, Thomas R; Margulies, Elliott H; Weng, Zhiping; Snyder, Michael; Dermitzakis, Emmanouil T; Thurman, Robert E; Kuehn, Michael S; Taylor, Christopher M; Neph, Shane; Koch, Christoph M; Asthana, Saurabh; Malhotra, Ankit; Adzhubei, Ivan; Greenbaum, Jason A; Andrews, Robert M; Flicek, Paul; Boyle, Patrick J; Cao, Hua; Carter, Nigel P; Clelland, Gayle K; Davis, Sean; Day, Nathan; Dhami, Pawandeep; Dillon, Shane C; Dorschner, Michael O; Fiegler, Heike; Giresi, Paul G; Goldy, Jeff; Hawrylycz, Michael; Haydock, Andrew; Humbert, Richard; James, Keith D; Johnson, Brett E; Johnson, Ericka M; Frum, Tristan T; Rosenzweig, Elizabeth R; Karnani, Neerja; Lee, Kirsten; Lefebvre, Gregory C; Navas, Patrick A; Neri, Fidencio; Parker, Stephen C J; Sabo, Peter J; Sandstrom, Richard; Shafer, Anthony; Vetrie, David; Weaver, Molly; Wilcox, Sarah; Yu, Man; Collins, Francis S; Dekker, Job; Lieb, Jason D; Tullius, Thomas D; Crawford, Gregory E; Sunyaev, Shamil; Noble, William S; Dunham, Ian; Denoeud, France; Reymond, Alexandre; Kapranov, Philipp; Rozowsky, Joel; Zheng, Deyou; Castelo, Robert; Frankish, Adam; Harrow, Jennifer; Ghosh, Srinka; Sandelin, Albin; Hofacker, Ivo L; Baertsch, Robert; Keefe, Damian; Dike, Sujit; Cheng, Jill; Hirsch, Heather A; Sekinger, Edward A; Lagarde, Julien; Abril, Josep F; Shahab, Atif; Flamm, Christoph; Fried, Claudia; Hackermüller, Jörg; Hertel, Jana; Lindemeyer, Manja; Missal, Kristin; Tanzer, Andrea; Washietl, Stefan; Korbel, Jan; Emanuelsson, Olof; Pedersen, Jakob S; Holroyd, Nancy; Taylor, Ruth; Swarbreck, David; Matthews, Nicholas; Dickson, Mark C; Thomas, Daryl J; Weirauch, Matthew T; Gilbert, James; Drenkow, Jorg; Bell, Ian; Zhao, XiaoDong; Srinivasan, K G; Sung, Wing-Kin; Ooi, Hong Sain; Chiu, Kuo Ping; Foissac, Sylvain; Alioto, Tyler; Brent, Michael; Pachter, Lior; Tress, Michael L; Valencia, Alfonso; Choo, Siew Woh; Choo, Chiou Yu; Ucla, Catherine; Manzano, Caroline; Wyss, Carine; Cheung, Evelyn; Clark, Taane G; Brown, James B; Ganesh, Madhavan; Patel, Sandeep; Tammana, Hari; Chrast, Jacqueline; Henrichsen, Charlotte N; Kai, Chikatoshi; Kawai, Jun; Nagalakshmi, Ugrappa; Wu, Jiaqian; Lian, Zheng; Lian, Jin; Newburger, Peter; Zhang, Xueqing; Bickel, Peter; Mattick, John S; Carninci, Piero; Hayashizaki, Yoshihide; Weissman, Sherman; Hubbard, Tim; Myers, Richard M; Rogers, Jane; Stadler, Peter F; Lowe, Todd M; Wei, Chia-Lin; Ruan, Yijun; Struhl, Kevin; Gerstein, Mark; Antonarakis, Stylianos E; Fu, Yutao; Green, Eric D; Karaöz, Ulaş; Siepel, Adam; Taylor, James; Liefer, Laura A; Wetterstrand, Kris A; Good, Peter J; Feingold, Elise A; Guyer, Mark S; Cooper, Gregory M; Asimenos, George; Dewey, Colin N; Hou, Minmei; Nikolaev, Sergey; Montoya-Burgos, Juan I; Löytynoja, Ari; Whelan, Simon; Pardi, Fabio; Massingham, Tim; Huang, Haiyan; Zhang, Nancy R; Holmes, Ian; Mullikin, James C; Ureta-Vidal, Abel; Paten, Benedict; Seringhaus, Michael; Church, Deanna; Rosenbloom, Kate; Kent, W James; Stone, Eric A; Batzoglou, Serafim; Goldman, Nick; Hardison, Ross C; Haussler, David; Miller, Webb; Sidow, Arend; Trinklein, Nathan D; Zhang, Zhengdong D; Barrera, Leah; Stuart, Rhona; King, David C; Ameur, Adam; Enroth, Stefan; Bieda, Mark C; Kim, Jonghwan; Bhinge, Akshay A; Jiang, Nan; Liu, Jun; Yao, Fei; Vega, Vinsensius B; Lee, Charlie W H; Ng, Patrick; Shahab, Atif; Yang, Annie; Moqtaderi, Zarmik; Zhu, Zhou; Xu, Xiaoqin; Squazzo, Sharon; Oberley, Matthew J; Inman, David; Singer, Michael A; Richmond, Todd A; Munn, Kyle J; Rada-Iglesias, Alvaro; Wallerman, Ola; Komorowski, Jan; Fowler, Joanna C; Couttet, Phillippe; Bruce, Alexander W; Dovey, Oliver M; Ellis, Peter D; Langford, Cordelia F; Nix, David A; Euskirchen, Ghia; Hartman, Stephen; Urban, Alexander E; Kraus, Peter; Van Calcar, Sara; Heintzman, Nate; Kim, Tae Hoon; Wang, Kun; Qu, Chunxu; Hon, Gary; Luna, Rosa; Glass, Christopher K; Rosenfeld, M Geoff; Aldred, Shelley Force; Cooper, Sara J; Halees, Anason; Lin, Jane M; Shulha, Hennady P; Zhang, Xiaoling; Xu, Mousheng; Haidar, Jaafar N S; Yu, Yong; Ruan, Yijun; Iyer, Vishwanath R; Green, Roland D; Wadelius, Claes; Farnham, Peggy J; Ren, Bing; Harte, Rachel A; Hinrichs, Angie S; Trumbower, Heather; Clawson, Hiram; Hillman-Jackson, Jennifer; Zweig, Ann S; Smith, Kayla; Thakkapallayil, Archana; Barber, Galt; Kuhn, Robert M; Karolchik, Donna; Armengol, Lluis; Bird, Christine P; de Bakker, Paul I W; Kern, Andrew D; Lopez-Bigas, Nuria; Martin, Joel D; Stranger, Barbara E; Woodroffe, Abigail; Davydov, Eugene; Dimas, Antigone; Eyras, Eduardo; Hallgrímsdóttir, Ingileif B; Huppert, Julian; Zody, Michael C; Abecasis, Gonçalo R; Estivill, Xavier; Bouffard, Gerard G; Guan, Xiaobin; Hansen, Nancy F; Idol, Jacquelyn R; Maduro, Valerie V B; Maskeri, Baishali; McDowell, Jennifer C; Park, Morgan; Thomas, Pamela J; Young, Alice C; Blakesley, Robert W; Muzny, Donna M; Sodergren, Erica; Wheeler, David A; Worley, Kim C; Jiang, Huaiyang; Weinstock, George M; Gibbs, Richard A; Graves, Tina; Fulton, Robert; Mardis, Elaine R; Wilson, Richard K; Clamp, Michele; Cuff, James; Gnerre, Sante; Jaffe, David B; Chang, Jean L; Lindblad-Toh, Kerstin; Lander, Eric S; Koriabine, Maxim; Nefedov, Mikhail; Osoegawa, Kazutoyo; Yoshinaga, Yuko; Zhu, Baoli; de Jong, Pieter J

    2007-06-14

    We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational analyses. Together, our results advance the collective knowledge about human genome function in several major areas. First, our studies provide convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts, including non-protein-coding transcripts, and those that extensively overlap one another. Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. Third, a more sophisticated view of chromatin structure has emerged, including its inter-relationship with DNA replication and transcriptional regulation. Finally, integration of these new sources of information, in particular with respect to mammalian evolution based on inter- and intra-species sequence comparisons, has yielded new mechanistic and evolutionary insights concerning the functional landscape of the human genome. Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function.

  13. Mercury contamination in fish from gold mining areas in Indonesia and human health risk assessment.

    PubMed

    Castilhos, Zuleica C; Rodrigues-Filho, Saulo; Rodrigues, Ana Paula C; Villas-Bôas, Roberto C; Siegel, Shefa; Veiga, Marcello M; Beinhoff, Christian

    2006-09-01

    This study investigates the effects on fish and assesses human health hazards from mercury released in two gold mining areas in Indonesia: Tatelu (North Sulawesi Province) and Galangan (Katingan District, Central Kalimatan Province). In Tatelu, 154 fish specimens of 10 freshwater species were collected, as well as five marine species from the fish market. The mean concentration of total mercury in muscles of freshwater fish from this area was 0.58+/-0.44 microg/g, with more than 45% of fish having Hg levels above the WHO guideline for human consumption of 0.5 microg/g. In Galangan, where 263 fish specimens of 25 species were collected, the total mercury in muscles averaged 0.25+/-0.69 microg/g. Excluding data from flooded open pits in sub-area P4, mean Hg levels in fish from Galangan were 2 to 4 times lower than 0.5 microg/g, while fewer than 10% of fish from Galangan exceeded WHO guidelines. The Hazard Quotient (HQ) was applied to both areas to determine the threat of MeHg exposure for communities in both areas. The HQ is a risk assessment indicator which defines the ratio of exposure level to a single substance in relation to a reference dose. Samples from Tatelu (excluding marine species) had an HQ above one, while those from Galangan resulted in values of 2.4 for the whole area and 9.9 for sub-area P4, pointing to potentially harmful fish consumption for the local population. By using the single-compartment model to estimate mercury levels in blood and hair from daily intake dose, sub-area P4 showed the highest levels, higher than the upper limit guideline for pregnant women, but still lower than threshold levels associated with observed clinical effects.

  14. Defining Face Perception Areas in the Human Brain: A Large-Scale Factorial fMRI Face Localizer Analysis

    ERIC Educational Resources Information Center

    Rossion, Bruno; Hanseeuw, Bernard; Dricot, Laurence

    2012-01-01

    A number of human brain areas showing a larger response to faces than to objects from different categories, or to scrambled faces, have been identified in neuroimaging studies. Depending on the statistical criteria used, the set of areas can be overextended or minimized, both at the local (size of areas) and global (number of areas) levels. Here…

  15. NASA Human Health and Performance Center: Open Innovation Successes and Collaborative Projects

    NASA Technical Reports Server (NTRS)

    Davis, Jeffrey R.; Richard, Elizabeth E.

    2014-01-01

    In May 2007, what was then the Space Life Sciences Directorate published the 2007 Space Life Sciences Strategy for Human Space Exploration, which resulted in the development and implementation of new business models and significant advances in external collaboration over the next five years. The strategy was updated on the basis of these accomplishments and reissued as the NASA Human Health and Performance Strategy in 2012, and continues to drive new approaches to innovation for the directorate. This short paper describes the open innovation successes and collaborative projects developed over this timeframe, including the efforts of the NASA Human Health and Performance Center (NHHPC), which was established to advance human health and performance innovations for spaceflight and societal benefit via collaboration in new markets.

  16. Human Spermatozoa as a Model for Detecting Missing Proteins in the Context of the Chromosome-Centric Human Proteome Project.

    PubMed

    Jumeau, Fanny; Com, Emmanuelle; Lane, Lydie; Duek, Paula; Lagarrigue, Mélanie; Lavigne, Régis; Guillot, Laëtitia; Rondel, Karine; Gateau, Alain; Melaine, Nathalie; Guével, Blandine; Sergeant, Nicolas; Mitchell, Valérie; Pineau, Charles

    2015-09-04

    The Chromosome-Centric Human Proteome Project (C-HPP) aims at cataloguing the proteins as gene products encoded by the human genome in a chromosome-centric manner. The existence of products of about 82% of the genes has been confirmed at the protein level. However, the number of so-called "missing proteins" remains significant. It was recently suggested that the expression of proteins that have been systematically missed might be restricted to particular organs or cell types, for example, the testis. Testicular function, and spermatogenesis in particular, is conditioned by the successive activation or repression of thousands of genes and proteins including numerous germ cell- and testis-specific products. Both the testis and postmeiotic germ cells are thus promising sites at which to search for missing proteins, and ejaculated spermatozoa are a potential source of proteins whose expression is restricted to the germ cell lineage. A trans-chromosome-based data analysis was performed to catalog missing proteins in total protein extracts from isolated human spermatozoa. We have identified and manually validated peptide matches to 89 missing proteins in human spermatozoa. In addition, we carefully validated three proteins that were scored as uncertain in the latest neXtProt release (09.19.2014). A focus was then given to the 12 missing proteins encoded on chromosomes 2 and 14, some of which may putatively play roles in ciliation and flagellum mechanistics. The expression pattern of C2orf57 and TEX37 was confirmed in the adult testis by immunohistochemistry. On the basis of transcript expression during human spermatogenesis, we further consider the potential for discovering additional missing proteins in the testicular postmeiotic germ cell lineage and in ejaculated spermatozoa. This project was conducted as part of the C-HPP initiatives on chromosomes 14 (France) and 2 (Switzerland). The mass spectrometry proteomics data have been deposited with the Proteome

  17. Speech-associated gestures, Broca’s area, and the human mirror system

    PubMed Central

    Skipper, Jeremy I.; Goldin-Meadow, Susan; Nusbaum, Howard C.; Small, Steven L

    2009-01-01

    Speech-associated gestures are hand and arm movements that not only convey semantic information to listeners but are themselves actions. Broca’s area has been assumed to play an important role both in semantic retrieval or selection (as part of a language comprehension system) and in action recognition (as part of a “mirror” or “observation–execution matching” system). We asked whether the role that Broca’s area plays in processing speech-associated gestures is consistent with the semantic retrieval/selection account (predicting relatively weak interactions between Broca’s area and other cortical areas because the meaningful information that speech-associated gestures convey reduces semantic ambiguity and thus reduces the need for semantic retrieval/selection) or the action recognition account (predicting strong interactions between Broca’s area and other cortical areas because speech-associated gestures are goal-direct actions that are “mirrored”). We compared the functional connectivity of Broca’s area with other cortical areas when participants listened to stories while watching meaningful speech-associated gestures, speech-irrelevant self-grooming hand movements, or no hand movements. A network analysis of neuroimaging data showed that interactions involving Broca’s area and other cortical areas were weakest when spoken language was accompanied by meaningful speech-associated gestures, and strongest when spoken language was accompanied by self-grooming hand movements or by no hand movements at all. Results are discussed with respect to the role that the human mirror system plays in processing speech-associated movements. PMID:17533001

  18. Large Area Crop Inventory Experiment (LACIE). Review of LACIE methodology, a project evaluation of technical acceptability

    NASA Technical Reports Server (NTRS)

    1976-01-01

    The author has identified the following significant results. Results indicated that the LANDSAT data and the classification technology can estimate the small grains area within a sample segment accurately and reliably enough to meet the LACIE goals. Overall, the LACIE estimates in a 9 x 11 kilometer segment agree well with ground and aircraft determined area within these segments. The estimated c.v. of the random classification error was acceptably small. These analyses confirmed that bias introduced by various factors, such as LANDSAT spatial resolution, lack of spectral resolution, classifier bias, and repeatability, was not excessive in terms of the required performance criterion. Results of these tests did indicate a difficulty in differentiating wheat from other closely related small grains. However, satisfactory wheat area estimates were obtained through the reduction of the small grain area estimates in accordance with relative amounts of these crops as determined from historic data; these procedures are being further refined.

  19. Genetic modification of the human germ line: The reasons why this project has no future.

    PubMed

    Morange, Michel

    2015-01-01

    Modification of the human germ line has remained a distant but valuable objective for most biologists since the emergence of genetics (and even before). To study the historical transformations of this project, I have selected three periods - the 1930s, at the pinnacle of eugenics, around 1974 when molecular biology triumphed, and today - and have adopted three criteria to estimate the feasibility of this project: the state of scientific knowledge, the existence of suitable tools, and societal demands. Although the long-awaited techniques to modify the germ line are now available, I will show that most of the expectations behind this project have disappeared, or are considered as being reachable by highly different strategies.

  20. The development of the human exploration demonstration project (HEDP), a planetary systems testbed

    NASA Technical Reports Server (NTRS)

    Chevers, Edward S.; Korsmeyer, David J.

    1993-01-01

    The Human Exploration Demonstration Project (HEDP) is an ongoing task at the National Aeronautics and Space Administration's Ames Research Center to address the advanced technology requirements necessary to implement an integrated working and living environment for a planetary surface habitat. The integrated environment will consist of life support systems, physiological monitoring of project crew, a virtual environment workstation, and centralized data acquisition and habitat systems health monitoring. There will be several robotic systems on a simulated planetary landscape external to the habitat environment to provide representative work loads for the crew. This paper describes the status of the HEDP after one year, the major facilities composing the HEDP, the project's role as an Ames Research Center testbed, and the types of demonstration scenarios that will be run to showcase the technologies.

  1. Iranian human genome project: Overview of a research process among Iranian ethnicities.

    PubMed

    Banihashemi, Kambiz

    2009-09-01

    The Human Genome Project (HGP) refers to the international scientific research program, formally begun in October 1990 and completed in 2003, mainly designated to discover all the human genes, analyzing the structure of human DNA and determining the location of all human genes and also making them accessible for further biological and medical investigations. With the appropriate rationale approach, a similar study has been held in Iran. The study of human genome among Iranian ethnicities (IHGP) has been attempted formally in 2000 through a detailed and fully programmed research among all the major ethnic groups by more than 1,900 samples from all over Iran based on the main demographical and anthropological findings and formally known criteria considered for the international HGP. This paper overviewed the process of the research in the terms of program goals, primary data collection, research designation and methodology and also practical aspects and primary findings of the Iranian genome project and its progress during a nearly 5-year period.

  2. Sacramento River Flood Control Project, California Mid-Valley Area, Phase 3. Design Memorandum Volume 1

    DTIC Science & Technology

    1996-06-01

    hydraulic excavator, crane, concrete pumps , loader, transit mixer, water trucks, and miscellaneous equipment. g. For other construction items, drainage...Flood Control Acts of December 1944 and May 1950 and incorporated under Sacramento River and Major and Minor Tributaries. Although construction of the...project was initiated in 1918, many of the levees were originally constructed by local interests prior to that time and subsequently modified and

  3. Environmental Assessment for East Housing Area Solar Energy Project, Vandenberg Air Force Base, California

    DTIC Science & Technology

    2014-07-01

    rounded pebbles of quartzite, igneous rocks and Monterey chert and shale (Dibblee 1950). 3.4.1 Soils Soils within VAFB are characterized by coastal...sand dunes and alluvium (i.e., sediment deposited by flowing water). VAFB is underlain predominately by marine sedimentary rocks (e.g., shales and... rocks underlying VAFB is the Franciscan Formation, which consists of a series of sedimentary and volcanic rocks (Dibblee 1950). The project site is

  4. Recreation Carrying Capacity Facts and Considerations. Report 5. Lake Shelbyville Project Area.

    DTIC Science & Technology

    1980-07-01

    Acknowledgements We gratefully acknowledge the enthusiasm and excellent cooperation of the resource managers , rangers, and other Corps personnel at Lake...survey analysis, and development of methodologies. Mr. R. Scott Jackson, WES was the Project Monitor. Dr. Adolph Anderson, WES, was Program Manager of the...Waterways Experiment Station’s (WES) Recreational Carrying Capacity Design and Management Study reports, provides selected carrying capacity-related

  5. IDF Sagebrush Habitat Mitigation Project: FY2008 Compensation Area Monitoring Report

    SciTech Connect

    Durham, Robin E.; Sackschewsky, Michael R.

    2008-09-01

    This document provides a review and status of activities conducted in support of the CH2MHill Hanford Group (CHG) Compensatory Mitigation Implementation Plan (MIP) for the Integrated Disposal Facility (IDF). It includes time-zero monitoring results for planting activities conducted in December 2007, annual survival monitoring for all planting years, a summary of artificial burrow observations, and recommendations for the successful completion of DOE mitigation commitments for this project.

  6. Birds of the Savannah Harbor Navigation Project, Dredged Material Disposal Areas, 19942012

    DTIC Science & Technology

    2016-03-01

    additional mitigation requirement, another bird island was created nearshore called Tomkins Island. This island provides approxi- mately 5 acres of...use vocalizations (e.g., pishing sounds or a mimicked or recorded screech owl call , or a combination of both). If no birds were detected within 15...ER D C/ EL T R- 16 -4 Dredging Operations Technical Support Program Birds of the Savannah Harbor Navigation Project, Dredged Material

  7. Protocadherin-alpha family is required for serotonergic projections to appropriately innervate target brain areas.

    PubMed

    Katori, Shota; Hamada, Shun; Noguchi, Yukiko; Fukuda, Emi; Yamamoto, Toshifumi; Yamamoto, Hideko; Hasegawa, Sonoko; Yagi, Takeshi

    2009-07-22

    Serotonergic axons from the raphe nuclei in the brainstem project to every region of the brain, where they make connections through their extensive terminal arborizations. This serotonergic innervation contributes to various normal behaviors and psychiatric disorders. The protocadherin-alpha (Pcdha) family of clustered protocadherins consists of 14 cadherin-related molecules generated from a single gene cluster. We found that the Pcdhas were strongly expressed in the serotonergic neurons. To elucidate their roles, we examined serotonergic fibers in a mouse mutant (Pcdha(Delta CR/Delta CR)) lacking the Pcdha cytoplasmic region-encoding exons, which are common to the gene cluster. In the first week after birth, the distribution pattern of serotonergic fibers in Pcdha(Delta CR/Delta CR) mice was similar to wild-type, but by 3 weeks of age, when the serotonergic axonal termini complete their arborizations, the distribution of the projections was abnormal. In some target regions, notably the globus pallidus and substantia nigra, the normally even distribution of serotonin axonal terminals was, in the mutants, dense at the periphery of each region, but sparse in the center. In the stratum lacunosum-molecular of the hippocampus, the mutants showed denser serotonergic innervation than in wild-type, and in the dentate gyrus of the hippocampus and the caudate-putamen, the innervation was sparser. Together, the abnormalities suggested that Pcdha proteins are important in the late-stage maturation of serotonergic projections. Further examination of alternatively spliced exons encoding the cytoplasmic tail showed that the A-type (but not the B-type) cytoplasmic tail was essential for the normal development of serotonergic projections.

  8. Determining Industrial Comparative Advantages in Areas of Proposed Water Navigation Projects: An Industrial Location Analysis.

    DTIC Science & Technology

    1981-12-01

    indirect forward and backward linkage (6) Second order Impacts associated with agglomeration and scale economies and the attainment of minimum...Methodology 3 2.0 Regional Impact of Water Resources Development 5 3.0 Industrial Location Anilysis 10 3.1 The General Theory 10 3.2 Determinants of...establish a general framework of a cause-effect relationship of water navigation projects and their effect on regions’ economies . Within this framework

  9. Hydrologic Resources Management Program and Underground Test Area Project FY 2001-2002 Progress Report

    SciTech Connect

    Rose, T P; Kersting, A B; Harris, L J; Hudson, G B; Smith, D K; Williams, R W; Loewen, D R; Nelson, E J; Allen, P G; Ryerson, F J; Pawloski, G A; Laue, C A; Moran, J E

    2003-08-15

    This report contains highlights of FY 2001 and 2002 technical studies conducted by the Analytical and Nuclear Chemistry Division (ANCD) at Lawrence Livermore National Laboratory (LLNL) in support of the Hydrologic Resources Management Program (HRMP) and the Underground Test Area (UGTA) Project. These programs are administered by the U.S. Department of Energy, National Nuclear Security Administration, Nevada Site Office (NNSA/NSO) through the Defense Programs and Environmental Restoration Divisions, respectively. HRMP-sponsored work emphasizes the Defense Programs goal of responsible management of natural resources at the NTS, while UGTA-funded work focuses on defining the extent of radionuclide contamination in NTS groundwater resulting from underground nuclear testing. The report is organized on a topical basis, and contains eight chapters that reflect the range of technical work performed by LLNL-ANCD in support of HRMP and UGTA. Chapter 1 describes recent hot well sampling efforts at the NTS, and presents the results of chemical and isotopic analyses of groundwater samples from six near-field wells. These include the Cambric (UE-5n), Bilby (U-3cn PS No.2), Bourbon (UE-7nS), Nash (UE-2ce), Tybo/Benham (ER-20-5 No.3), and Almendro (U-19v PS No.1ds) sites. The data generated by the hot well program is vital to the development and validation of contaminant transport models at the NTS. Chapter 2 discusses the results of xenon isotope measurements of groundwater samples from the six near-field wells described in Chapter 1. This work demonstrates that fission xenon is present in the water at levels that are readily measurable and highlights the significant differences in xenon concentrations and isotopic abundances at different sites. These differences provide insight into the early cooling history of nuclear test cavities, and may assist in predicting the distribution of the source term in the near-field environment. Chapter 3 is an investigation of the distribution

  10. Epidemiology of human brucellosis in a defined area of Northwestern Greece.

    PubMed Central

    Avdikou, I.; Maipa, V.; Alamanos, Y.

    2005-01-01

    Despite a European co-financial programme for control and eradication of brucellosis in Southern Europe, there is evidence that foci of brucellosis still exists in Greece and other Southern European countries. Human brucellosis cases are probably underreported in these countries. A local surveillance system was implemented in a defined region of Northwestern Greece, in order to record and study all human brucellosis cases, using several sources of retrieval. A total of 152 newly diagnosed cases were recorded during a 2-year study period (from 1 April 2002 to 31 March 2004). The age- and sex-adjusted mean annual incidence rate for the population of the study area was 17.3 cases/10(5) inhabitants. Incomplete application of the control and eradication programme in livestock, and the possible illegal trafficking of animals and their products across the Greek-Albanian border could be responsible for the persistence of foci of brucellosis in the area. PMID:16181512

  11. Human factors considerations of IR sensors for the Canadian Integrated Soldier System Project (ISSP)

    NASA Astrophysics Data System (ADS)

    Frim, John; Bossi, Linda; Tack, Dave

    2009-05-01

    The Integrated Soldier System Project (ISSP) is the cornerstone of Canada's future soldier modernization effort, which seeks to "significantly enhance tactical level individual and team Lethality, Mobility and C4I performance in the complex, network-enabled, command-centric, effects-based digitized battlespace." This capital acquisition project is supported by a number of R&D Technology Demonstration Projects within Defence R&D Canada. Several of these projects focus on the human factors aspects of future technologies, such as IR sensors. The Soldier Information Requirements Technology Demonstration (SIREQ TD) project examined the performance impact of NVGs, LWIR imaging systems, and fused systems (both optical and digital fusion) on target detection, recognition and identification. NVGs were shown to provide good identification performance while LWIR systems excelled in detection tasks. Fused systems show promise of augmenting the respective stand alone capabilities of each sensor type, but more work is required to optimize fusion algorithms. The Soldier Integrated Headwear Technology Demonstration (SIHS TD) project is looking at the human factors aspects of mounting a range of vision enhancement sensors on a helmet, including optimal placement of both sensors and displays with respect to center of mass, total head borne weight, and visual offset and parallax issues. Overall headwear system weight should be less than 2.5 kg, and if an offset from the eye is required then a horizontal offset (vice vertical or oblique) of the sensor appears most acceptable. These findings have implications on the design of future IR and fused sensor systems for dismounted soldiers.

  12. [The Russian part of the human proteome project:first results and prospects].

    PubMed

    Ponomarenko, E A; Zgoda, V G; Kopylov, A T; Poverennaya, E V; Ilgisonis, E V; Lisitsa, A V; Archakov, A I

    2015-01-01

    The article summarizes the achievements of the pilot phase (2010-2014) of the Russian part of the international project "Human Proteome" and identifies the directions for further work on the study of the human chromosome 18 proteome in the framework of the project main phase (2015-2022). The pilot phase of the project was focused on the detection of at least one protein for each chromosome 18 protein-coding gene in three types of the biological material. The application of mass spectrometric detection of proteins by the methods of multiple reactions monitoring (MRM) and gene-centric approach made it possible to detect 95% of master forms of proteins, for 60% of which the quantitative assessment of the protein content was obtained in at least one type of the biological material. The task of the main phase of the project is to measure the proteome size of healthy individuals, taking into account the modified protein forms, providing for both the bioinformatics prediction of the quantity of proteins types and the selective experimental measurement of single proteoforms. Since the ranges of protein concentrations corresponding to the normal physiological state have not been identified, the work of the main phase of the project is focused on the study of clinically healthy individuals. The absence of these data complicates significantly the interpretation of the patients' blood proteomic profiles and prevents creating diagnostic tests. In the long term prospect, implementation of the project envisages development of a diagnostic test system based on multiple reactions monitoring (MRM) for quantitative measurement of the protein forms associated with some diseases. Development of such test systems will allow predicting the extent of risk of different diseases, diagnosing a disease at its early stage and monitoring the effectiveness of the treatment.

  13. Climate extremes in urban area and their impact on human health: the summer heat waves

    NASA Astrophysics Data System (ADS)

    Baldi, Marina

    2014-05-01

    In the period 1951-2012 the average global land and ocean temperature has increased by approximately 0.72°C [0.49-0.89] when described by a linear trend, and is projected to rapidly increase. Each of the past three decades has been warmer than all the previous decades, with the decade of the 2000's as the warmest, and, since 1880, nine of the ten warmest years are in the 21st century, the only exception being 1998, which was warmed by the strongest El Niño event of the past century. In parallel an increase in the frequency and intensity of extremely hot days is detected with differences at different scales, which represent an health risk specially in largely populated areas as documented for several regions in the world including the Euro-Mediterranean region. If it is still under discussion if heat wave episodes are a direct result of the warming of the lower troposphere, or if, more likely, they are a regional climate event, however heat episodes have been studied in order to define their correlation with large scale atmospheric patterns and with changes in the regional circulation. Whatever the causes and the spatio-temporal extension of the episodes, epidemiological studies show that these conditions pose increasing health risks inducing heat-related diseases including hyperthermia and heat stress, cardiovascular and respiratory illnesses in susceptible individuals with a significant increase in morbidity and mortality especially in densely populated urban areas. In several Mediterranean cities peaks of mortality associated with extremely high temperature (with simultaneous high humidity levels) have been documented showing that, in some cases, a large increase in daily mortality has been reached compared to the average for the period. The number of fatalities during the summer 2003 heat wave in Europe was estimated to largely exceed the average value of some between 22000 and 50000 cases. In the same summer it was also unusually hot across much of Asia, and

  14. Quality Improvement Project to Improve Patient Satisfaction With Pain Management: Using Human-Centered Design.

    PubMed

    Trail-Mahan, Tracy; Heisler, Scott; Katica, Mary

    2016-01-01

    In this quality improvement project, our health system developed a comprehensive, patient-centered approach to improving inpatient pain management and assessed its impact on patient satisfaction across 21 medical centers. Using human-centered design principles, a bundle of 6 individual and team nursing practices was developed. Patient satisfaction with pain management, as measured by the Hospital Consumer Assessment of Healthcare Providers and Systems pain composite score, increased from the 25th to just under the 75th national percentile.

  15. Fringe-projection method for three-dimensional digitization of human faces

    NASA Astrophysics Data System (ADS)

    Picos, Kenia; Juarez-Salazar, Rigoberto; Díaz-Ramírez, Víctor H.

    2016-09-01

    A reliable method for three-dimensional digitization of human faces based on the fringe projection technique is presented. The proposed method employs robust fringe analysis algorithms for robust phase computation. The quality of the resultant 3D face model is characterized in terms of accuracy of surface computation using objective metrics. We present experimental results obtained with real and synthetic laboratory objects. The potential of this method to be used in the field of face recognition is discussed.

  16. Projecting future grassland productivity to assess the sustainability of potential biofuel feedstock areas in the Greater Platte River Basin

    USGS Publications Warehouse

    Gu, Yingxin; Wylie, Bruce K.; Boyte, Stephen; Phyual, Khem

    2014-01-01

    This study projects future (e.g., 2050 and 2099) grassland productivities in the Greater Platte River Basin (GPRB) using ecosystem performance (EP, a surrogate for measuring ecosystem productivity) models and future climate projections. The EP models developed from a previous study were based on the satellite vegetation index, site geophysical and biophysical features, and weather and climate drivers. The future climate data used in this study were derived from the National Center for Atmospheric Research Community Climate System Model 3.0 ‘SRES A1B’ (a ‘middle’ emissions path). The main objective of this study is to assess the future sustainability of the potential biofuel feedstock areas identified in a previous study. Results show that the potential biofuel feedstock areas (the more mesic eastern part of the GPRB) will remain productive (i.e., aboveground grassland biomass productivity >2750 kg ha−1 year−1) with a slight increasing trend in the future. The spatially averaged EPs for these areas are 3519, 3432, 3557, 3605, 3752, and 3583 kg ha−1 year−1 for current site potential (2000–2008 average), 2020, 2030, 2040, 2050, and 2099, respectively. Therefore, the identified potential biofuel feedstock areas will likely continue to be sustainable for future biofuel development. On the other hand, grasslands identified as having no biofuel potential in the drier western part of the GPRB would be expected to stay unproductive in the future (spatially averaged EPs are 1822, 1691, 1896, 2306, 1994, and 2169 kg ha−1 year−1 for site potential, 2020, 2030, 2040, 2050, and 2099). These areas should continue to be unsuitable for biofuel feedstock development in the future. These future grassland productivity estimation maps can help land managers to understand and adapt to the expected changes in future EP in the GPRB and to assess the future sustainability and feasibility of potential biofuel feedstock areas.

  17. [MATCHE: Management Approach to Teaching Consumer and Homemaking Education.] Economically Depressed Areas Strand: Human Development. Module III-E-1: Characteristics of Economically Depressed Areas Families.

    ERIC Educational Resources Information Center

    California State Univ., Fresno. Dept. of Home Economics.

    This competency-based preservice home economics teacher education module on characteristics of economically depressed area families is the first in a set of three modules on human development in economically depressed areas (EDA). (This set is part of a larger set of sixty-seven modules on the Management Approach to Teaching Consumer and…

  18. [MATCHE: Management Approach to Teaching Consumer and Homemaking Education.] Economically Depressed Areas Strand: Human Development. Module III-E-2: The Child and the Economically Depressed Area Family.

    ERIC Educational Resources Information Center

    Boogaert, John

    This competency-based preservice home economics teacher education module on the child and the economically depressed area family is the second in a set of three modules on human development in economically depressed areas (EDA). (This set is part of a larger set of sixty-seven modules on the Management Approach to Teaching Consumer and Homemaking…

  19. Ventral visual cortex in humans: cytoarchitectonic mapping of two extrastriate areas.

    PubMed

    Rottschy, Claudia; Eickhoff, Simon B; Schleicher, Axel; Mohlberg, Hartmurt; Kujovic, Milenko; Zilles, Karl; Amunts, Katrin

    2007-10-01

    The extrastriate visual cortex forms a complex system enabling the analysis of visually presented objects. To gain deeper insight into the anatomical basis of this system, we cytoarchitectonically mapped the ventral occipital cortex lateral to BA 18/V2 in 10 human postmortem brains. The anatomical characterization of this part of the ventral stream was performed by examination of cell-body-stained histological sections using quantitative cytoarchitectonic analysis. First, the gray level index (GLI) was measured in the ventral occipital lobe. Cytoarchitectonic borders, i.e., significant changes in the cortical lamination pattern, were then identified using an observer-independent algorithm based on multivariate analysis of GLI profiles. Two distinct cytoarchitectonic areas (hOC3v, hOC4v) were characterized in the ventral extrastriate cortex lateral to BA 18/V2. Area hOC3v was found in the collateral sulcus. hOC4v was located in this sulcus and also covered the fusiform gyrus in more occipital sections. Topographically, these areas thus seem to represent the anatomical substrates of functionally defined areas, VP/V3v and V4/V4v. Following histological analysis, the delineated cytoarchitectonic areas were transferred to 3D reconstructions of the respective postmortem brains, which in turn were spatially normalized to the Montreal Neurological Institute reference space. A probabilistic map was generated for each area which describes how many brains had a representation of this area in a particular voxel. These maps can now be used to identify the anatomical correlates of functional activations observed in neuroimaging experiments to enable a more informed investigation into the many open questions regarding the organization of the human visual cortex.

  20. Documenting genomics: Applying archival theory to preserving the records of the Human Genome Project.

    PubMed

    Shaw, Jennifer

    2016-02-01

    The Human Genome Archive Project (HGAP) aimed to preserve the documentary heritage of the UK's contribution to the Human Genome Project (HGP) by using archival theory to develop a suitable methodology for capturing the results of modern, collaborative science. After assessing past projects and different archival theories, the HGAP used an approach based on the theory of documentation strategy to try to capture the records of a scientific project that had an influence beyond the purely scientific sphere. The HGAP was an archival survey that ran for two years. It led to ninety scientists being contacted and has, so far, led to six collections being deposited in the Wellcome Library, with additional collections being deposited in other UK repositories. In applying documentation strategy the HGAP was attempting to move away from traditional archival approaches to science, which have generally focused on retired Nobel Prize winners. It has been partially successful in this aim, having managed to secure collections from people who are not 'big names', but who made an important contribution to the HGP. However, the attempt to redress the gender imbalance in scientific collections and to improve record-keeping in scientific organisations has continued to be difficult to achieve.