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Sample records for human systems integration

  1. Human Systems Integration Introduction

    NASA Video Gallery

    This lecture provides an overview of Human Systems Integration (HSI), its implementation cost and return on investment, HSI domains, how HSI fits into the NASA organization structure, HSI roles and...

  2. Human Factors in Human-Systems Integration

    NASA Technical Reports Server (NTRS)

    Fitts, David J.; Sandor, Aniko; Litaker, Harry L., Jr.; Tillman, Barry

    2008-01-01

    Any large organization whose mission is to design and develop systems for humans, and train humans needs a well-developed integration and process plan to deal with the challenges that arise from managing multiple subsystems. Human capabilities, skills, and needs must be considered early in the design and development process, and must be continuously considered throughout the development lifecycle. This integration of human needs within system design is typically formalized through a Human-Systems Integration (HSI) program. By having an HSI program, an institution or organization can reduce lifecycle costs and increase the efficiency, usability, and quality of its products because human needs have been considered from the beginning.

  3. Human System Integration: Regulatory Analysis

    NASA Technical Reports Server (NTRS)

    2005-01-01

    This document was intended as an input to the Access 5 Policy Integrated Product team. Using a Human System Integration (HIS) perspective, a regulatory analyses of the FARS (specifically Part 91), the Airman s Information Manual (AIM) and the FAA Controllers Handbook (7110.65) was conducted as part of a front-end approach needed to derive HSI requirements for Unmanned Aircraft Systems (UAS) operations in the National Airspace System above FL430. The review of the above aviation reference materials yielded eighty-four functions determined to be necessary or highly desirable for flight within the Air Traffic Management System. They include categories for Flight, Communications, Navigation, Surveillance, and Hazard Avoidance.

  4. Human Systems Integration in the Federal Government

    NASA Technical Reports Server (NTRS)

    Jones, Patricia M.; Graves, Gaye L.; Allard, Terry; Blackhurst, Jack; Fitts, David J.; Peters, Sean; Piccione, Dino; Shattuck, Lawrence G.

    2010-01-01

    Human Systems Integration principles and methods can be used to help integrate people, technology, and organizations in an effective and efficient manner. Over the past decade, a wide range of tools, techniques, and technologies have been developed by federal agencies to achieve significant cost and performance benefits. In this discussion, we will explore trends in military human systems integration and learn about the critical role being played by human performance and effectiveness research. We will also examine case studies on the planning and design of future human space flight vehicles, the national air space system and the first nuclear reactors to be built in the United States in over 30 years. And with an eye toward sustaining the discipline s principles and methods, we ll take a look at educating and training the next generation of human systems integration practitioners.

  5. NASA UAS Integration into the NAS Project: Human Systems Integration

    NASA Technical Reports Server (NTRS)

    Shively, Jay

    2016-01-01

    This presentation provides an overview of the work the Human Systems Integration (HSI) sub-project has done on detect and avoid (DAA) displays while working on the UAS (Unmanned Aircraft System) Integration into the NAS project. The most recent simulation on DAA interoperability with Traffic Collision Avoidance System (TCAS) is discussed in the most detail. The relationship of the work to the larger UAS community and next steps are also detailed.

  6. Development of Human System Integration at NASA

    NASA Technical Reports Server (NTRS)

    Whitmore, Mihriban; McGuire, Kerry; Thompson, Shelby; Vos, Gordon

    2012-01-01

    Human Systems Integration seeks to design systems around the capabilities and limitations of the humans which use and interact with the system, ensuring greater efficiency of use, reduced error rates, and less rework in the design, manufacturing and operational deployment of hardware and software. One of the primary goals of HSI is to get the human factors practitioner involved early in the design process. In doing so, the aim is to reduce future budget costs and resources in redesign and training. By the preliminary design phase of a project nearly 80% of the total cost of the project is locked in. Potential design changes recommended by evaluations past this point will have little effect due to lack of funding or a huge cost in terms of resources to make changes. Three key concepts define an effective HSI program. First, systems are comprised of hardware, software, and the human, all of which operate within an environment. Too often, engineers and developers fail to consider the human capacity or requirements as part of the system. This leads to poor task allocation within the system. To promote ideal task allocation, it is critical that the human element be considered early in system development. Poor design, or designs that do not adequately consider the human component, could negatively affect physical or mental performance, as well as, social behavior. Second, successful HSI depends upon integration and collaboration of all the domains that represent acquisition efforts. Too often, these domains exist as independent disciplines due to the location of expertise within the service structure. Proper implementation of HSI through participation would help to integrate these domains and disciplines to leverage and apply their interdependencies to attain an optimal design. Via this process domain interests can be integrated to perform effective HSI through trade-offs and collaboration. This provides a common basis upon which to make knowledgeable decisions. Finally

  7. Human Systems Integration (HSI) Practitioner's Guide

    NASA Technical Reports Server (NTRS)

    Zumbado, Jennifer Rochlis

    2015-01-01

    The NASA/SP-2015-3709, Human Systems Integration (HSI) Practitioner's Guide, also known as the "HSIPG," provides a tool for implementing HSI activities within the NASA systems engineering framework. The HSIPG is written to aid the HSI practitioner engaged in a program or project (P/P), and serves as a knowledge base to allow the practitioner to step into an HSI lead or team member role for NASA missions. Additionally, this HSIPG is written to address the role of HSI in the P/P management and systems engineering communities and aid their understanding of the value added by incorporating good HSI practices into their programs and projects. Through helping to build a community of knowledgeable HSI practitioners, this document also hopes to build advocacy across the Agency for establishing strong, consistent HSI policies and practices. Human Systems Integration (HSI) has been successfully adopted (and adapted) by several federal agencies-most notably the U.S. Department of Defense (DoD) and the Nuclear Regulatory Commission (NRC)-as a methodology for reducing system life cycle costs (LCCs). These cost savings manifest themselves due to reductions in required numbers of personnel, the practice of human-centered design, decreased reliance on specialized skills for operations, shortened training time, efficient logistics and maintenance, and fewer safety-related risks and mishaps due to unintended human/system interactions. The HSI process for NASA establishes how cost savings and mission success can be realized through systems engineering. Every program or project has unique attributes. This HSIPG is not intended to provide one-size-fits-all recommendations for HSI implementation. Rather, HSI processes should be tailored to the size, scope, and goals of individual situations. The instructions and processes identified here are best used as a starting point for implementing human-centered system concepts and designs across programs and projects of varying types, including

  8. Integrating Spaceflight Human System Risk Research

    NASA Technical Reports Server (NTRS)

    Mindock, J.; Lumpkins, S.; Anton, W.; Havenhill, M.; Shelhamer, M.; Canga, M.

    2016-01-01

    NASA is working to increase the likelihoods of human health and performance success during exploration missions, and subsequent crew long-term health. To manage the risks in achieving these goals, a system modeled after a Continuous Risk Management framework is in place. "Human System Risks" (Risks) have been identified, and approximately 30 are being actively addressed by NASA's Human Research Program (HRP). Research plans for each of HRP's Risks have been developed and are being executed. Ties between the research efforts supporting each Risk have been identified, however, this has been in an ad hoc fashion. There is growing recognition that solutions developed to address the full set of Risks covering medical, physiological, behavioral, vehicle, and organizational aspects of the exploration missions must be integrated across Risks and disciplines. We will discuss how a framework of factors influencing human health and performance in space is being applied as the backbone for bringing together sometimes disparate information relevant to the individual Risks. The resulting interrelated information is allowing us to identify and visualize connections between Risks and research efforts in a systematic and standardized way. We will discuss the applications of the visualizations and insights to research planning, solicitation, and decision-making processes.

  9. Integrating Spaceflight Human System Risk Research

    NASA Technical Reports Server (NTRS)

    Mindock, Jennifer; Lumpkins, Sarah; Anton, Wilma; Havenhill, Maria; Shelhamer, Mark; Canga, Michael

    2016-01-01

    NASA is working to increase the likelihood of human health and performance success during exploration missions as well as to maintain the subsequent long-term health of the crew. To manage the risks in achieving these goals, a system modelled after a Continuous Risk Management framework is in place. "Human System Risks" (Risks) have been identified, and approximately 30 are being actively addressed by NASA's Human Research Program (HRP). Research plans for each of HRP's Risks have been developed and are being executed. Inter-disciplinary ties between the research efforts supporting each Risk have been identified; however, efforts to identify and benefit from these connections have been mostly ad hoc. There is growing recognition that solutions developed to address the full set of Risks covering medical, physiological, behavioural, vehicle, and organizational aspects of exploration missions must be integrated across Risks and disciplines. This paper discusses how a framework of factors influencing human health and performance in space is being applied as the backbone for bringing together sometimes disparate information relevant to the individual Risks. The resulting interrelated information enables identification and visualization of connections between Risks and research efforts in a systematic and standardized manner. This paper also discusses the applications of the visualizations and insights into research planning, solicitation, and decision-making processes.

  10. An Overview of the Human Systems Integration Division

    NASA Technical Reports Server (NTRS)

    Gore, Brian F.

    2015-01-01

    This presentation will provide an overview of the Human Systems Integration Division, and will highlight some of the human performance modeling efforts undertaken in previously presented MIDAS human performance modeling efforts.

  11. Human Systems Integration: Requirements and Functional Decomposition

    NASA Technical Reports Server (NTRS)

    Berson, Barry; Gershzohn, Gary; Boltz, Laura; Wolf, Russ; Schultz, Mike

    2005-01-01

    This deliverable was intended as an input to the Access 5 Policy and Simulation Integrated Product Teams. This document contains high-level pilot functionality for operations in the National Airspace System above FL430. Based on the derived pilot functions the associated pilot information and control requirements are given.

  12. Human Systems Integration in Practice: Constellation Lessons Learned

    NASA Technical Reports Server (NTRS)

    Zumbado, Jennifer Rochlis

    2012-01-01

    NASA's Constellation program provided a unique testbed for Human Systems Integration (HSI) as a fundamental element of the Systems Engineering process. Constellation was the first major program to have HSI mandated by NASA's Human Rating document. Proper HSI is critical to the success of any project that relies on humans to function as operators, maintainers, or controllers of a system. HSI improves mission, system and human performance, significantly reduces lifecycle costs, lowers risk and minimizes re-design. Successful HSI begins with sufficient project schedule dedicated to the generation of human systems requirements, but is by no means solely a requirements management process. A top-down systems engineering process that recognizes throughout the organization, human factors as a technical discipline equal to traditional engineering disciplines with authority for the overall system. This partners with a bottoms-up mechanism for human-centered design and technical issue resolution. The Constellation Human Systems Integration Group (HSIG) was a part of the Systems Engineering and Integration (SE&I) organization within the program office, and existed alongside similar groups such as Flight Performance, Environments & Constraints, and Integrated Loads, Structures and Mechanisms. While the HSIG successfully managed, via influence leadership, a down-and-in Community of Practice to facilitate technical integration and issue resolution, it lacked parallel top-down authority to drive integrated design. This presentation will discuss how HSI was applied to Constellation, the lessons learned and best practices it revealed, and recommendations to future NASA program and project managers. This presentation will discuss how Human Systems Integration (HSI) was applied to NASA's Constellation program, the lessons learned and best practices it revealed, and recommendations to future NASA program and project managers on how to accomplish this critical function.

  13. Integrated Reproduction of Human Motion Components by Motion Copying System

    NASA Astrophysics Data System (ADS)

    Tsunashima, Noboru; Katsura, Seiichiro

    Currently, the development of leading-edge technology for recording and loading human motion on the basis of haptic information is required in the field of manufacturing and human support. Human movement is an assembly of motion components. Since human movements should be supported by a robot in real time, it is necessary to integrate the morion components, which were saved earlier. Once such motion integration is realized, future technology for use in daily human life is developed. This paper proposes the integrated reproduction of the decomposed components of human motion by using a motion copying system. This system is the key technology for the realization of the acquisition, saving and reproduction of the real-world haptic information. By the proposed method, it is possible not only to achieve expert skill acquisition, skill transfer to robots, and power assist for each motion component but also to open up new areas of applications.

  14. Integrated human-machine intelligence in space systems

    NASA Technical Reports Server (NTRS)

    Boy, Guy A.

    1992-01-01

    The integration of human and machine intelligence in space systems is outlined with respect to the contributions of artificial intelligence. The current state-of-the-art in intelligent assistant systems (IASs) is reviewed, and the requirements of some real-world applications of the technologies are discussed. A concept of integrated human-machine intelligence is examined in the contexts of: (1) interactive systems that tolerate human errors; (2) systems for the relief of workloads; and (3) interactive systems for solving problems in abnormal situations. Key issues in the development of IASs include the compatibility of the systems with astronauts in terms of inputs/outputs, processing, real-time AI, and knowledge-based system validation. Real-world applications are suggested such as the diagnosis, planning, and control of enginnered systems.

  15. Cultural Development through Human Resource Systems Integration.

    ERIC Educational Resources Information Center

    Albert, Michael

    1985-01-01

    Discusses the framework for developing a cultural human resources management (HRM) perspective. Central to this framework is modifying HRM programs to reinforce the organization's preferred practices. Modification occurs through selection, orientation, training and development, performance appraisal, career development, and compensation and…

  16. Simulation of a steady-state integrated human thermal system.

    NASA Technical Reports Server (NTRS)

    Hsu, F. T.; Fan, L. T.; Hwang, C. L.

    1972-01-01

    The mathematical model of an integrated human thermal system is formulated. The system consists of an external thermal regulation device on the human body. The purpose of the device (a network of cooling tubes held in contact with the surface of the skin) is to maintain the human body in a state of thermoneutrality. The device is controlled by varying the inlet coolant temperature and coolant mass flow rate. The differential equations of the model are approximated by a set of algebraic equations which result from the application of the explicit forward finite difference method to the differential equations. The integrated human thermal system is simulated for a variety of combinations of the inlet coolant temperature, coolant mass flow rate, and metabolic rates.

  17. Human in the Loop Integrated Life Support Systems Ground Testing

    NASA Technical Reports Server (NTRS)

    Henninger, Donald L.; Marmolejo, Jose A.; Seaman, Calvin H.

    2012-01-01

    Human exploration missions beyond low earth orbit will be long duration with abort scenarios of days to months. This necessitates provisioning the crew with all the things they will need to sustain themselves while carrying out mission objectives. Systems engineering and integration is critical to the point where extensive integrated testing of life support systems on the ground is required to identify and mitigate risks. Ground test facilities (human-rated altitude chambers) at the Johnson Space Center are being readied to integrate all the systems for a mission along with a human test crew. The relevant environment will include deep space habitat human accommodations, sealed atmosphere capable of 14.7 to 8 psi total pressure and 21 to 32% oxygen concentration, life support systems (food, air, and water), communications, crew accommodations, medical, EVA, tools, etc. Testing periods will approximate those of the expected missions (such as a near Earth asteroid, Earth-Moon L2 or L1, the moon, Mars). This type of integrated testing is needed for research and technology development as well as later during the mission design, development, test, and evaluation (DDT&E) phases of an approved program. Testing will evolve to be carried out at the mission level fly the mission on the ground . Mission testing will also serve to inform the public and provide the opportunity for active participation by international, industrial and academic partners.

  18. An Integrated Simulation Tool for Modeling the Human Circulatory System

    NASA Astrophysics Data System (ADS)

    Asami, Ken'ichi; Kitamura, Tadashi

    This paper presents an integrated simulation of the circulatory system in physiological movement. The large circulatory system model includes principal organs and functional units in modules in which comprehensive physiological changes such as nerve reflexes, temperature regulation, acid/base balance, O2/CO2 balance, and exercise are simulated. A beat-by-beat heart model, in which the corresponding electrical circuit problems are solved by a numerical analytic method, enables calculation of pulsatile blood flow to the major organs. The integration of different perspectives on physiological changes makes this simulation model applicable for the microscopic evaluation of blood flow under various conditions in the human body.

  19. Unifying Human Centered Design and Systems Engineering for Human Systems Integration

    NASA Technical Reports Server (NTRS)

    Boy, Guy A.; McGovernNarkevicius, Jennifer

    2013-01-01

    Despite the holistic approach of systems engineering (SE), systems still fail, and sometimes spectacularly. Requirements, solutions and the world constantly evolve and are very difficult to keep current. SE requires more flexibility and new approaches to SE have to be developed to include creativity as an integral part and where the functions of people and technology are appropriately allocated within our highly interconnected complex organizations. Instead of disregarding complexity because it is too difficult to handle, we should take advantage of it, discovering behavioral attractors and the emerging properties that it generates. Human-centered design (HCD) provides the creativity factor that SE lacks. It promotes modeling and simulation from the early stages of design and throughout the life cycle of a product. Unifying HCD and SE will shape appropriate human-systems integration (HSI) and produce successful systems.

  20. Simulation of a steady-state integrated human thermal system.

    NASA Technical Reports Server (NTRS)

    Hsu, F. T.; Fan, L. T.; Hwang, C. L.

    1972-01-01

    The mathematical model of an integrated human thermal system is formulated. The system consists of an external thermal regulation device on the human body. The purpose of the device (a network of cooling tubes held in contact with the surface of the skin) is to maintain the human body in a state of thermoneutrality. The device is controlled by varying the inlet coolant temperature and coolant mass flow rate. The differential equations of the model are approximated by a set of algebraic equations which result from the application of the explicit forward finite difference method to the differential equations. The integrated human thermal system is simulated for a variety of combinations of the inlet coolant temperature, coolant mass flow rate, and metabolic rates. Two specific cases are considered: (1) the external thermal regulation device is placed only on the head and (2) the devices are placed on the head and the torso. The results of the simulation indicate that when the human body is exposed to hot environment, thermoneutrality can be attained by localized cooling if the operating variables of the external regulation device(s) are properly controlled.

  1. Tool for Human-Systems Integration Assessment: HSI Scorecard

    NASA Technical Reports Server (NTRS)

    Whitmore, Nihriban; Sandor, Aniko; McGuire, Kerry M.; Berdich, Debbie

    2009-01-01

    This paper describes the development and rationale for a human-systems integration (HSI) scorecard that can be used in reviews of vehicle specification and design. This tool can be used to assess whether specific HSI related criteria have been met as part of a project milestone or critical event, such as technical reviews, crew station reviews, mockup evaluations, or even review of major plans or processes. Examples of HSI related criteria include Human Performance Capabilities, Health Management, Human System Interfaces, Anthropometry and Biomechanics, and Natural and Induced Environments. The tool is not intended to evaluate requirements compliance and verification, but to review how well the human related systems have been considered for the specific event and to identify gaps and vulnerabilities from an HSI perspective. The scorecard offers common basis, and criteria for discussions among system managers, evaluators, and design engineers. Furthermore, the scorecard items highlight the main areas of system development that need to be followed during system lifecycle. The ratings provide a repeatable quantitative measure to what has been often seen as only subjective commentary. Thus, the scorecard is anticipated to be a useful HSI tool to communicate review results to the institutional and the project office management.

  2. Postmodernism and Humanism: A Proposed Integration of Perspectives That Value Human Meaning Systems

    ERIC Educational Resources Information Center

    Hansen, James T.

    2005-01-01

    Both postmodernism and humanism place a high value on individual differences in meaning systems. However, there are significant theoretical barriers to integrating these systems into a counseling orientation. A theoretical integration is proposed, along with implications for counseling practice. The purpose of this article is to explore the…

  3. Space Medicine in the Human System Integration Process

    NASA Technical Reports Server (NTRS)

    Scheuring, Richard A.

    2010-01-01

    This slide presentation reviews the importance of integration of space medicine in the human system of lunar exploration. There is a review of historical precedence in reference to lunar surface operations. The integration process is reviewed in a chart which shows the steps from research to requirements development, requirements integration, design, verification, operations and using the lessons learned, giving more information and items for research. These steps are reviewed in view of specific space medical issues. Some of the testing of the operations are undertaken in an environment that is an analog to the exploration environment. Some of these analog environments are reviewed, and there is some discussion of the benefits of use of an analog environment in testing the processes that are derived.

  4. NASA Space Flight Human System Standard, Volume 2, and HIDH (Human Integration Design Handbook)

    NASA Technical Reports Server (NTRS)

    Connolly, Janis; Fitts, David; Stroud, Kenneth; Boyer, Jennifer; Holubec, Keith; Tillman, Barry

    2009-01-01

    This viewgraph presentation reports on the review and re-issuance of the NASA Space Flight Human System Standard, Volume 2, and the Human Integration Design Handbook. These standards were last updated in 1995. The target date for the release is September 2009.

  5. Human-System Integration Scorecard Update to VB.Net

    NASA Technical Reports Server (NTRS)

    Sanders, Blaze D.

    2009-01-01

    The purpose of this project was to create Human-System Integration (HSI) scorecard software, which could be utilized to validate that human factors have been considered early in hardware/system specifications and design. The HSI scorecard is partially based upon the revised Human Rating Requirements (HRR) intended for NASA's Constellation program. This software scorecard will allow for quick appraisal of HSI factors, by using visual aids to highlight low and rapidly changing scores. This project consisted of creating a user-friendly Visual Basic program that could be easily distributed and updated, to and by fellow colleagues. Updating the Microsoft Word version of the HSI scorecard to a computer application will allow for the addition of useful features, improved easy of use, and decreased completion time for user. One significant addition is the ability to create Microsoft Excel graphs automatically from scorecard data, to allow for clear presentation of problematic areas. The purpose of this paper is to describe the rational and benefits of creating the HSI scorecard software, the problems and goals of project, and future work that could be done.

  6. NASA-STD-3001, Space Flight Human-System Standard and the Human Integration Design Handbook

    NASA Technical Reports Server (NTRS)

    Whitmore, Mihriban; Boyer, Jennifer; Holubec, Keith

    2012-01-01

    NASA-STD-3001 Space Flight Human-System Standard Volume 1, Crew Health, Volume 2, Human Factors, Habitability and Environmental Health, and the Human Integration Design Handbook (HIDH) have replaced the Man-Systems Integration Standards (MSIS), NASA-STD-3000. For decades, NASA-STD-3000 was a significant contribution to human spaceflight programs and to human-systems integration. However, with research program and project results being realized, advances in technology, and the availability of new information in a variety of topic areas, the time had arrived to update this extensive suite of standards and design information. NASA-STD-3001, Volume 2 contains the Agency level standards from the human and environmental factors disciplines that ensure human spaceflight operations are performed safely, efficiently, and effectively. The HIDH is organized in the same sequence and serves as the companion document to NASA-STD-3001, Volume 2, providing a compendium of human spaceflight history and knowledge. The HIDH is intended to aid interpretation of NASA-STD-3001, Volume 2 standards and to provide guidance for requirement writers and vehicle and habitat designers. Keywords Human Factors, Standards, Environmental Factors, NASA

  7. Temporal integration of light flashes by the human circadian system

    PubMed Central

    Najjar, Raymond P.; Zeitzer, Jamie M.

    2016-01-01

    BACKGROUND. Beyond image formation, the light that is detected by retinal photoreceptors influences subcortical functions, including circadian timing, sleep, and arousal. The physiology of nonimage-forming (NIF) photoresponses in humans is not well understood; therefore, the development of therapeutic interventions based on this physiology, such as bright light therapy to treat chronobiological disorders, remains challenging. METHODS. Thirty-nine participants were exposed to 60 minutes of either continuous light (n = 8) or sequences of 2-millisecond light flashes (n = 31) with different interstimulus intervals (ISIs; ranging from 2.5 to 240 seconds). Melatonin phase shift and suppression, along with changes in alertness and sleepiness, were assessed. RESULTS. We determined that the human circadian system integrates flash sequences in a nonlinear fashion with a linear rise to a peak response (ISI = 7.6 ± 0.53 seconds) and a power function decrease following the peak of responsivity. At peak ISI, flashes were at least 2-fold more effective in phase delaying the circadian system as compared with exposure to equiluminous continuous light 3,800 times the duration. Flashes did not change melatonin concentrations or alertness in an ISI-dependent manner. CONCLUSION. We have demonstrated that intermittent light is more effective than continuous light at eliciting circadian changes. These findings cast light on the phenomenology of photic integration and suggest a dichotomous retinohypothalamic network leading to circadian phase shifting and other NIF photoresponses. Further clinical trials are required to judge the practicality of light flash protocols. TRIAL REGISTRATION. Clinicaltrials.gov NCT01119365. FUNDING. National Heart, Lung, and Blood Institute (1R01HL108441-01A1) and Department of Veterans Affairs Sierra Pacific Mental Illness Research, Education, and Clinical Center. PMID:26854928

  8. Human system integration considerations for tactical head-mounted displays

    NASA Astrophysics Data System (ADS)

    Burnett, Gregory M.; Hoover, Jeffery L.; Racine, Matthew S.; Sedillo, Michael R.

    2010-04-01

    As computer-use propagates across the battlefield, the necessity to effectively integrate such system components challenges the system developer to find a balance between added functionality and system usability. The most significant challenge is ruggedizing and integrating these technologies in an acceptable manner that does not impede the users' combat capability, but instead significantly enhances it . In this paper, researchers at the Air Force Research Laboratory's Battlespace Acoustics Branch explored alternative Head Mounted Display (HMD) concepts, investigating field of view as well as ease of use concerns. Special Operations personnel prosecute mission objectives in dynamic environments requiring an agile integration solution that is equally accommodating. This report describes the research process as well as the unique concerns and results of integrating tactical HMDs for special operation forces. Issues involving variable use-cases, as well as cable management are also addressed.

  9. Human-technology Integration

    NASA Astrophysics Data System (ADS)

    Mullen, Katharine M.

    Human-technology integration is the replacement of human parts and extension of human capabilities with engineered devices and substrates. Its result is hybrid biological-artificial systems. We discuss here four categories of products furthering human-technology integration: wearable computers, pervasive computing environments, engineered tissues and organs, and prosthetics, and introduce examples of currently realized systems in each category. We then note that realization of a completely artificial sytem via the path of human-technology integration presents the prospect of empirical confirmation of an aware artificially embodied system.

  10. Integrated modeling of natural and human systems - problems and initiatives

    NASA Astrophysics Data System (ADS)

    Kessler, H.; Giles, J.; Gunnink, J.; Hughes, A.; Moore, R. V.; Peach, D.

    2009-12-01

    Governments and their executive agencies across the world are facing increasing pressure to make decisions about the management of resources in light of population growth and environmental change. In the UK and the Netherlands, for example, groundwater is becoming a scarce resource for large parts of its most densely populated areas. At the same time river and groundwater flooding resulting from high rainfall events are increasing in scale and frequency and sea level rise is threatening the defences of coastal cities. There is also a need for affordable housing, improved transport infrastructure and waste disposal as well as sources of renewable energy and sustainable food production. These challenges can only be resolved if solutions are based on sound scientific evidence. Although we have knowledge and understanding of many individual processes in the natural sciences it is clear that a single science discipline is unable to answer the questions and their inter-relationships. Modern science increasingly employs computer models to simulate the natural, economic and human system. Management and planning requires scenario modelling, forecasts and “predictions”. Although the outputs are often impressive in terms of apparent accuracy and visualisation, they are inherently not suited to simulate the response to feedbacks from other models of the earth system, such as the impact of human actions. Geological Survey Organisations (GSO) are increasingly employing advances in Information Technology to visualise and improve their understanding of geological systems. Instead of 2 dimensional paper maps and reports many GSOs now produce 3 dimensional geological framework models and groundwater flow models as their standard output. Additionally the British Geological Survey and the Geological Survey of the Netherlands have developed standard routines to link geological data to groundwater models, but these models are only aimed at solving one specific part of the earth

  11. Development of an integrated system for estimating human error probabilities

    SciTech Connect

    Auflick, J.L.; Hahn, H.A.; Morzinski, J.A.

    1998-12-01

    This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). This project had as its main objective the development of a Human Reliability Analysis (HRA), knowledge-based expert system that would provide probabilistic estimates for potential human errors within various risk assessments, safety analysis reports, and hazard assessments. HRA identifies where human errors are most likely, estimates the error rate for individual tasks, and highlights the most beneficial areas for system improvements. This project accomplished three major tasks. First, several prominent HRA techniques and associated databases were collected and translated into an electronic format. Next, the project started a knowledge engineering phase where the expertise, i.e., the procedural rules and data, were extracted from those techniques and compiled into various modules. Finally, these modules, rules, and data were combined into a nearly complete HRA expert system.

  12. Advancing coupled human-earth system models: The integrated Earth System Model Project

    NASA Astrophysics Data System (ADS)

    Thomson, A. M.; Edmonds, J. A.; Collins, W.; Thornton, P. E.; Hurtt, G. C.; Janetos, A. C.; Jones, A.; Mao, J.; Chini, L. P.; Calvin, K. V.; Bond-Lamberty, B. P.; Shi, X.

    2012-12-01

    As human and biogeophysical models develop, opportunities for connections between them evolve and can be used to advance our understanding of human-earth systems interaction in the context of a changing climate. One such integration is taking place with the Community Earth System Model (CESM) and the Global Change Assessment Model (GCAM). A multi-disciplinary, multi-institution team has succeeded in integrating the GCAM integrated assessment model of human activity into CESM to dynamically represent the feedbacks between changing climate and human decision making, in the context of greenhouse gas mitigation policies. The first applications of this capability have focused on the feedbacks between climate change impacts on terrestrial ecosystem productivity and human decisions affecting future land use change, which are in turn connected to human decisions about energy systems and bioenergy production. These experiments have been conducted in the context of the RCP4.5 scenario, one of four pathways of future radiative forcing being used in CMIP5, which constrains future human-induced greenhouse gas emissions from energy and land activities to stabilize radiative forcing at 4.5 W/m2 (~650 ppm CO2 -eq) by 2100. When this pathway is run in GCAM with the climate feedback on terrestrial productivity from CESM, there are implications for both the land use and energy system changes required for stabilization. Early findings indicate that traditional definitions of radiative forcing used in scenario development are missing a critical component of the biogeophysical consequences of land use change and their contribution to effective radiative forcing. Initial full coupling of the two global models has important implications for how climate impacts on terrestrial ecosystems changes the dynamics of future land use change for agriculture and forestry, particularly in the context of a climate mitigation policy designed to reduce emissions from land use as well as energy systems

  13. Access 5 - Step 1: Human Systems Integration Program Plan (HSIPP)

    NASA Technical Reports Server (NTRS)

    2005-01-01

    This report describes the Human System Interface (HSI) analysis, design and test activities that will be performed to support the development of requirements and design guidelines to facilitate the incorporation of High Altitude Long Endurance (HALE) Remotely Operated Aircraft (ROA) at or above FL400 in the National Airspace System (NAS). These activities are required to support the design and development of safe, effective and reliable ROA operator and ATC interfaces. This plan focuses on the activities to be completed for Step 1 of the ACCESS 5 program. Updates to this document will be made for each of the four ACCESS 5 program steps.

  14. "On the Augmented Cognition Approach to Early Warning Systems- Human System Integration NASA Experiance

    NASA Astrophysics Data System (ADS)

    Achimowicz, Jerzy; Bakowski, Rafal; Mazur, Andrzej

    2014-05-01

    The authors present results related to the implementation of augmented cognition approach to severe weather early warning systems in aviation and aerospace operational environment. The limitations of automation and adaptive approach in severe weather warning systems are discussed. Also the positive impact of HSI (Human System Integration) NASA approach will be shown, in the process of pilot training in minimal weather conditions. The flight safety procedures related to weather conditions will be analyzed and the meteorological general aviation weather support product developed at IMGW will be presented. Special emphasis will be put on the integration of the military and civilian weather radar/lighting detection systems and the impact of space weather on aerospace operations including the use of unmanned RPAS (Remotely Controlled Aircraf Systems). J.Z. Achimowicz is also affiliated with Flight Safety Division of Military Institute of Aviation Medicine, Warsaw, Poland.

  15. Human Systems Integration (HSI) Case Studies from the NASA Constellation Program

    NASA Technical Reports Server (NTRS)

    Baggerman, Susan; Berdich, Debbie; Whitmore, Mihriban

    2009-01-01

    The National Aeronautics and Space Administration (NASA) Constellation Program is responsible for planning and implementing those programs necessary to send human explorers back to the moon, onward to Mars and other destinations in the solar system, and to support missions to the International Space Station. The Constellation Program has the technical management responsibility for all Constellation Projects, including both human rated and non-human rated vehicles such as the Crew Exploration Vehicle, EVA Systems, the Lunar Lander, Lunar Surface Systems, and the Ares I and Ares V rockets. With NASA s new Vision for Space Exploration to send humans beyond Earth orbit, it is critical to consider the human as a system that demands early and continuous user involvement, inclusion in trade offs and analyses, and an iterative "prototype/test/ redesign" process. Personnel at the NASA Johnson Space Center are involved in the Constellation Program at both the Program and Project levels as human system integrators. They ensure that the human is considered as a system, equal to hardware and software vehicle systems. Systems to deliver and support extended human habitation on the moon are extremely complex and unique, presenting new opportunities to employ Human Systems Integration, or HSI practices in the Constellation Program. The purpose of the paper is to show examples of where human systems integration work is successfully employed in the Constellation Program and related Projects, such as in the areas of habitation and early requirements and design concepts.

  16. Constellation Program Human-System Integration Requirements. Revision E, Nov. 19, 2010

    NASA Technical Reports Server (NTRS)

    Dory, Jonathan

    2010-01-01

    The Human-Systems Integration Requirements (HSIR) in this document drive the design of space vehicles, their systems, and equipment with which humans interface in the Constellation Program (CxP). These requirements ensure that the design of Constellation (Cx) systems is centered on the needs, capabilities, and limitations of the human. The HSIR provides requirements to ensure proper integration of human-to-system interfaces. These requirements apply to all mission phases, including pre-launch, ascent, Earth orbit, trans-lunar flight, lunar orbit, lunar landing, lunar ascent, Earth return, Earth entry, Earth landing, post-landing, and recovery. The Constellation Program must meet NASA's Agency-level human rating requirements, which are intended to ensure crew survival without permanent disability. The HSIR provides a key mechanism for achieving human rating of Constellation systems.

  17. Integrating the human element into the systems engineering process and MBSE methodology.

    SciTech Connect

    Tadros, Michael Samir.

    2013-12-01

    In response to the challenges related to the increasing size and complexity of systems, organizations have recognized the need to integrate human considerations in the beginning stages of systems development. Human Systems Integration (HSI) seeks to accomplish this objective by incorporating human factors within systems engineering (SE) processes and methodologies, which is the focus of this paper. A representative set of HSI methods from multiple sources are organized, analyzed, and mapped to the systems engineering Vee-model. These methods are then consolidated and evaluated against the SE process and Models-Based Systems Engineering (MBSE) methodology to determine where and how they could integrate within systems development activities in the form of specific enhancements. Overall conclusions based on these evaluations are presented and future research areas are proposed.

  18. Systems integrated human engineering on the Navy's rapid acquisition of manufactured parts/test and integration facility

    NASA Technical Reports Server (NTRS)

    Gallaway, Glen R.

    1987-01-01

    Human Engineering in many projects is at best a limited support function. In this Navy project the Human Engineering function is an integral component of the systems design and development process. Human Engineering is a member of the systems design organization. This ensures that people considerations are: (1) identified early in the project; (2) accounted for in the specifications; (3) incorporated into the design; and (4) the tested product meets the needs and expectations of the people while meeting the overall systems requirements. The project exemplifies achievements that can be made by the symbiosis between systems designers, engineers and Human Engineering. This approach increases Human Engineering's effectiveness and value to a project because it becomes an accepted, contributing team member. It is an approach to doing Human Engineering that should be considered for most projects. The functional and organizational issues giving this approach strength are described.

  19. Human Systems Integration: Unmanned Aircraft Control Station Certification Plan Guidance

    NASA Technical Reports Server (NTRS)

    2005-01-01

    This document provides guidance to the FAA on important human factors considerations that can be used to support the certification of a UAS Aircraft Control Station (ACS). This document provides a synopsis of the human factors analysis, design and test activities to be performed to provide a basis for FAA certification. The data from these analyses, design activities, and tests, along with data from certification/qualification tests of other key components should be used to establish the ACS certification basis. It is expected that this information will be useful to manufacturers in developing the ACS Certification Plan,, and in supporting the design of their ACS.

  20. NASA's Man-Systems Integration Standards: A Human Factors Engineering Standard for Everyone in the Nineties

    NASA Technical Reports Server (NTRS)

    Booher, Cletis R.; Goldsberry, Betty S.

    1994-01-01

    During the second half of the 1980s, a document was created by the National Aeronautics and Space Administration (NASA) to aid in the application of good human factors engineering and human interface practices to the design and development of hardware and systems for use in all United States manned space flight programs. This comprehensive document, known as NASA-STD-3000, the Man-Systems Integration Standards (MSIS), attempts to address, from a human factors engineering/human interface standpoint, all of the various types of equipment with which manned space flight crew members must deal. Basically, all of the human interface situations addressed in the MSIS are present in terrestrially based systems also. The premise of this paper is that, starting with this already created standard, comprehensive documents addressing human factors engineering and human interface concerns could be developed to aid in the design of almost any type of equipment or system which humans interface with in any terrestrial environment. Utilizing the systems and processes currently in place in the MSIS Development Facility at the Johnson Space Center in Houston, TX, any number of MSIS volumes addressing the human factors / human interface needs of any terrestrially based (or, for that matter, airborne) system could be created.

  1. Human-in-the-Loop Integrated Life Support Systems Ground Testing

    NASA Technical Reports Server (NTRS)

    Henninger, Donald L.; Marmolejo, Jose A.; Westheimer, David T.

    2011-01-01

    Human exploration missions beyond low earth orbit will be long duration with abort scenarios of days to months. This necessitates provisioning the crew with all the things they will need to sustain themselves while carrying out mission objectives. Systems engineering and integration is critical to the point where extensive integrated testing of life support systems on the ground is required to identify and mitigate risks. Ground test facilities (human-rated altitude chamber) at the Johnson Space Center are being readied to integrate all the systems for a mission along with a human test crew. The relevant environment will include deep space habitat human accommodations, sealed atmosphere of 8 psi total pressure and 32% oxygen concentration, life support systems (food, air, water), communications, crew accommodations, medical, EVA, tools, etc. Testing periods will approximate those of the expected missions (such as a near Earth asteroid, Earth-Moon L2 or L1, the moon). This type of integrated testing is needed for research and technology development as well as later during the mission design, development, test, and evaluation (DDT&E) phases of an approved program. Testing will evolve to be carried out at the mission level fly the mission on the ground . Mission testing will also serve to inform the public and provide the opportunity for active participation by international partners.

  2. Space Flight Human System Standards (SFHSS). Volume 2; Human Factors, Habitability and Environmental Factors" and Human Integration Design Handbook (HIDH)

    NASA Technical Reports Server (NTRS)

    Davis, Jeffrey R.; Fitts, David J.

    2009-01-01

    This viewgraph presentation reviews the standards for space flight hardware based on human capabilities and limitations. The contents include: 1) Scope; 2) Applicable documents; 3) General; 4) Human Physical Characteristics and Capabilities; 5) Human Performance and Cognition; 6) Natural and Induced Environments; 7) Habitability Functions; 8) Architecture; 9) Hardware and Equipment; 10) Crew Interfaces; 11) Spacesuits; 12) Operatons: Reserved; 13) Ground Maintenance and Assembly: Reserved; 14) Appendix A-Reference Documents; 15) Appendix N-Acronyms and 16) Appendix C-Definition. Volume 2 is supported by the Human Integration Design Handbook (HIDH)s.

  3. Step 1: Human System Integration Simulation and Flight Test Progress Report

    NASA Technical Reports Server (NTRS)

    2005-01-01

    The Access 5 Human Systems Integration Work Package produced simulation and flight demonstration planning products for use throughout the program. These included: Test Objectives for Command, Control, Communications; Pilot Questionnaire for Command, Control, Communications; Air Traffic Controller Questionnaire for Command, Control, Communications; Test Objectives for Collision Avoidance; Pilot Questionnaire for Collision Avoidance; Plans for Unmanned Aircraft Systems Control Station Simulations Flight Requirements for the Airspace Operations Demonstration

  4. NASA's UAS Integration into the NAS: A Report on the Human Systems Integration Phase 1 Simulation Activities

    NASA Technical Reports Server (NTRS)

    Fern, Lisa; Rorie, R. Conrad; Shively, R. Jay

    2014-01-01

    In 2011 the National Aeronautics and Space Administration (NASA) began a five-year Project to address the technical barriers related to routine access of Unmanned Aerial Systems (UAS) in the National Airspace System (NAS). Planned in two phases, the goal of the first phase was to lay the foundations for the Project by identifying those barriers and key issues to be addressed to achieve integration. Phase 1 activities were completed two years into the five-year Project. The purpose of this paper is to review activities within the Human Systems Integration (HSI) subproject in Phase 1 toward its two objectives: 1) develop GCS guidelines for routine UAS access to the NAS, and 2) develop a prototype display suite within an existing Ground Control Station (GCS). The first objective directly addresses a critical barrier for UAS integration into the NAS - a lack of GCS design standards or requirements. First, the paper describes the initial development of a prototype GCS display suite and supporting simulation software capabilities. Then, three simulation experiments utilizing this simulation architecture are summarized. The first experiment sought to determine a baseline performance of UAS pilots operating in civil airspace under current instrument flight rules for manned aircraft. The second experiment examined the effect of currently employed UAS contingency procedures on Air Traffic Control (ATC) participants. The third experiment compared three GCS command and control interfaces on UAS pilot response times in compliance with ATC clearances. The authors discuss how the results of these and future simulation and flight-testing activities contribute to the development of GCS guidelines to support the safe integration of UAS into the NAS. Finally, the planned activities for Phase 2, including an integrated human-in-the-loop simulation and two flight tests are briefly described.

  5. Human Systems Integration and Automation Issues in Small Unmanned Aerial Vehicles

    NASA Technical Reports Server (NTRS)

    McCauley, Michael E.; Matsangas, Panagiotis

    2004-01-01

    The goal of this report is to identify Human System Integration (HSI) and automation issues that contribute to improved effectiveness and efficiency in the operation of U.S. military Small Unmanned Aerial Vehicles (SUAVs). HSI issues relevant to SUAV operations are reviewed and observations from field trials are summarized. Short-term improvements are suggested research issues are identified and an overview is provided of automation technologies applicable to future SUAV design.

  6. Human factors analysis and design methods for nuclear waste retrieval systems. Human factors design methodology and integration plan

    SciTech Connect

    Casey, S.M.

    1980-06-01

    The purpose of this document is to provide an overview of the recommended activities and methods to be employed by a team of human factors engineers during the development of a nuclear waste retrieval system. This system, as it is presently conceptualized, is intended to be used for the removal of storage canisters (each canister containing a spent fuel rod assembly) located in an underground salt bed depository. This document, and the others in this series, have been developed for the purpose of implementing human factors engineering principles during the design and construction of the retrieval system facilities and equipment. The methodology presented has been structured around a basic systems development effort involving preliminary development, equipment development, personnel subsystem development, and operational test and evaluation. Within each of these phases, the recommended activities of the human engineering team have been stated, along with descriptions of the human factors engineering design techniques applicable to the specific design issues. Explicit examples of how the techniques might be used in the analysis of human tasks and equipment required in the removal of spent fuel canisters have been provided. Only those techniques having possible relevance to the design of the waste retrieval system have been reviewed. This document is intended to provide the framework for integrating human engineering with the rest of the system development effort. The activities and methodologies reviewed in this document have been discussed in the general order in which they will occur, although the time frame (the total duration of the development program in years and months) in which they should be performed has not been discussed.

  7. In-vehicle human factors for integrated multi-function systems: Making ITS user-friendly

    SciTech Connect

    Spelt, P.F.; Scott, S.

    1998-04-01

    As more and more Intelligent Transportation System in-vehicle equipment enters the general consumer market, the authors are about to find out how different design engineers are from ordinary drivers. Driver information systems are being developed and installed in vehicles at an ever-increasing rate. These systems provide information on diverse topics of concern and convenience to the driver, such as routing and navigation, emergency and collision warnings, and a variety of motorists services, or yellow pages functions. Most of these systems are being developed and installed in isolation from each other, with separate means of gathering the information and of displaying it to the driver. The current lack of coordination among on-board systems threatens to create a situation in which different messages on separate displays will be competing with each other for the drivers attention. Urgent messages may go unnoticed, and the number of messages may distract the driver from the most critical task of controlling the vehicle. Thus, without good human factors design and engineering for integrating multiple systems in the vehicle, consumers may find ITS systems confusing and frustrating to use. The current state of the art in human factors research and design for in-vehicle systems has a number of fundamental gaps. Some of these gaps were identified during the Intelligent Vehicle Initiative Human Factors Technology Workshop, sponsored by the US Department of Transportation, in Troy, Michigan, December 10--11, 1997. One task for workshop participants was to identify needed research areas or topics relating to in-vehicle human factors. The top ten unmet research needs from this workshop are presented. Many of these gaps in human factors research knowledge indicate the need for standardization in the functioning of interfaces for safety-related devices such as collision avoidance systems (CAS) and adaptive cruise controls (ACC). Such standards and guidelines will serve to make

  8. Integrated human surveillance systems of West Nile virus infections in Italy: the 2012 experience.

    PubMed

    Napoli, Christian; Bella, Antonino; Declich, Silvia; Grazzini, Giuliano; Lombardini, Letizia; Nanni Costa, Alessandro; Nicoletti, Loredana; Pompa, Maria Grazia; Pupella, Simonetta; Russo, Francesca; Rizzo, Caterina

    2013-12-01

    In Italy, a West Nile virus (WNV) surveillance plan was firstly implemented in 2008 and 2009 in two affected regions and, since 2010, according to a national plan, a WNV neuroinvasive disease (WNND) surveillance has to be carried out each year during the period 15 June-30 November, in those regions where WNV circulation has been demonstrated among humans, animals or vectors. Moreover, since WNV can be transmitted to humans even by blood transfusions and organ transplants obtained from infected donors, the national surveillance integrates the blood transfusions and organs transplant surveillances too. The paper describes the results of this integrated human surveillance in Italy in 2012. Overall, in 2012, 28 autochthonous confirmed cases of WNND were reported, 14 blood donations were found WNV positive by Nucleic Acid Amplification Test and no solid organ donors tested positive for WNV. Moreover, 17 cases of WNV fever were confirmed in Veneto region. When comparing the number of WNND cases reported to the surveillance system in previous 4 years (43 cases during the period 2008-2011), with those reported in 2012 an important increase was observed in 2012. The geographic distribution of human cases was consistent with the WNV circulation among animals and vectors. Moreover, the implementation of preventive measures for WNV transmission through blood components allowed the detection of blood donors positive for WNV, avoiding the further spread of the disease. Since surveillance strategies and preventive measures are based on the integration among human, animal and vector control activities, the Italian experience could be considered a good example of collaboration among different sectors of public health in a "one health" perspective. PMID:24351740

  9. An integrated mathematical model of the human cardiopulmonary system: model development.

    PubMed

    Albanese, Antonio; Cheng, Limei; Ursino, Mauro; Chbat, Nicolas W

    2016-04-01

    Several cardiovascular and pulmonary models have been proposed in the last few decades. However, very few have addressed the interactions between these two systems. Our group has developed an integrated cardiopulmonary model (CP Model) that mathematically describes the interactions between the cardiovascular and respiratory systems, along with their main short-term control mechanisms. The model has been compared with human and animal data taken from published literature. Due to the volume of the work, the paper is divided in two parts. The present paper is on model development and normophysiology, whereas the second is on the model's validation on hypoxic and hypercapnic conditions. The CP Model incorporates cardiovascular circulation, respiratory mechanics, tissue and alveolar gas exchange, as well as short-term neural control mechanisms acting on both the cardiovascular and the respiratory functions. The model is able to simulate physiological variables typically observed in adult humans under normal and pathological conditions and to explain the underlying mechanisms and dynamics. PMID:26683899

  10. The telerobot workstation testbed for the shuttle aft flight deck: A project plan for integrating human factors into system design

    NASA Technical Reports Server (NTRS)

    Sauerwein, Timothy

    1989-01-01

    The human factors design process in developing a shuttle orbiter aft flight deck workstation testbed is described. In developing an operator workstation to control various laboratory telerobots, strong elements of human factors engineering and ergonomics are integrated into the design process. The integration of human factors is performed by incorporating user feedback at key stages in the project life-cycle. An operator centered design approach helps insure the system users are working with the system designer in the design and operation of the system. The design methodology is presented along with the results of the design and the solutions regarding human factors design principles.

  11. Implementation of the totally integrated hospital information system (Humane) in Osaka University Hospital.

    PubMed

    Matsumura, Y; Takeda, H; Inoue, M

    1995-01-01

    On September 1, 1993, in the new Osaka University Hospital, we implemented a new hospital information system named "HUMANE" (Human oriented Universal Medical Assessment system by Network Environment). We had planned to organize a more effective and efficient medical care system in the new hospital and improve the medical services to patients. To succeed in constructing a totally integrated hospital information system, the original data must be entered. Most of it would be entered by doctors who are not accustomed to the operation of a computer system, thus the production of a good man-machine interface is indispensable. For this reason, we adopted a micro-medium-main frame link system for the system configuration. The interface program and the copy of the master data about each subsystem are located on the microframe. Although, all patient data is stored on the mainframe, most of the active patients' data is delivered to the mediumframe before the data is requested. This system design makes it possible to shorten the response time and to use a comfortable user interface. On the basis of this system configuration, we made subsystems that support hospital management, for example, an ordering system, a reporting system, a reservation system, a supporting system for hospitalization, a nurse supporting system, and so on. These systems promote automation control in each central service division; pharmacy, radiology, laboratory for clinical investigation and accounting section, resulting in man-power being saved. At the same time, medical service to patients is improved, because waiting time is shortened and redundant examinations or prescription are avoided. PMID:8591271

  12. Human factors considerations of IR sensors for the Canadian Integrated Soldier System Project (ISSP)

    NASA Astrophysics Data System (ADS)

    Frim, John; Bossi, Linda; Tack, Dave

    2009-05-01

    The Integrated Soldier System Project (ISSP) is the cornerstone of Canada's future soldier modernization effort, which seeks to "significantly enhance tactical level individual and team Lethality, Mobility and C4I performance in the complex, network-enabled, command-centric, effects-based digitized battlespace." This capital acquisition project is supported by a number of R&D Technology Demonstration Projects within Defence R&D Canada. Several of these projects focus on the human factors aspects of future technologies, such as IR sensors. The Soldier Information Requirements Technology Demonstration (SIREQ TD) project examined the performance impact of NVGs, LWIR imaging systems, and fused systems (both optical and digital fusion) on target detection, recognition and identification. NVGs were shown to provide good identification performance while LWIR systems excelled in detection tasks. Fused systems show promise of augmenting the respective stand alone capabilities of each sensor type, but more work is required to optimize fusion algorithms. The Soldier Integrated Headwear Technology Demonstration (SIHS TD) project is looking at the human factors aspects of mounting a range of vision enhancement sensors on a helmet, including optimal placement of both sensors and displays with respect to center of mass, total head borne weight, and visual offset and parallax issues. Overall headwear system weight should be less than 2.5 kg, and if an offset from the eye is required then a horizontal offset (vice vertical or oblique) of the sensor appears most acceptable. These findings have implications on the design of future IR and fused sensor systems for dismounted soldiers.

  13. Step 1: Human System Integration Pilot-Technology Interface Requirements for Weather Management

    NASA Technical Reports Server (NTRS)

    2005-01-01

    This document involves definition of technology interface requirements for Hazardous Weather Avoidance. Technology concepts in use by the Access 5 Weather Management Work Package were considered. Beginning with the Human System Integration (HIS) high-level functional requirement for Hazardous Weather Avoidance, and Hazardous Weather Avoidance technology elements, HSI requirements for the interface to the pilot were identified. Results of the analysis describe (1) the information required by the pilot to have knowledge of hazardous weather, and (2) the control capability needed by the pilot to obtain hazardous weather information. Fundamentally, these requirements provide the candidate Hazardous Weather Avoidance technology concepts with the necessary human-related elements to make them compatible with human capabilities and limitations. The results of the analysis describe how Hazardous Weather Avoidance operations and functions should interface with the pilot to provide the necessary Weather Management functionality to the UA-pilot system. Requirements and guidelines for Hazardous Weather Avoidance are partitioned into four categories: (1) Planning En Route (2) Encountering Hazardous Weather En Route, (3) Planning to Destination, and (4) Diversion Planning Alternate Airport. Each requirement is stated and is supported with a rationale and associated reference(s).

  14. Integrated photoacoustic and diffuse optical tomography system for imaging of human finger joints in vivo.

    PubMed

    Xi, Lei; Jiang, Huabei

    2016-03-01

    In this study, we developed a dual-modality tomographic system that integrated photoacoustic imaging (PAI) and diffuse optical tomography (DOT) into a single platform for imaging human finger joints with fine structures and associated optical properties. In PAI, spherical focused transducers were utilized to collect acoustic signals, and the concept of virtual detector was applied in a conventional back-projection algorithm to improve the image quality. A finite-element based reconstruction algorithm was employed to quantitatively recover optical property distribution in the objects for DOT. The phantom results indicate that PAI has a maximum lateral resolution of 70 µm in resolving structures of targets. DOT was able to recover both optical absorption and reduced scattering coefficients of targets accurately. To validate the potential of this system in clinical diagnosis of joint diseases, the distal interphalangeal (DIP) joints of 4 healthy female volunteers were imaged. We successfully obtained high-resolution images of the phalanx and the surrounding soft tissue via PAI, and recovered both optical absorption and reduced scattering coefficients of phalanx using DOT. The in vivo results suggest that this dual-modality system has the potential for the early diagnosis of joint diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). Integrated PAI/DOT imaging interface (top) and typical reconstruction of structures and associated optical properties of a female finger joint via PAI and DOT (bottom). PMID:26431473

  15. The Work Compatibility Improvement Framework: an integrated perspective of the human-at-work system.

    PubMed

    Genaidy, Ash; Salem, Sam; Karwowski, Waldemar; Paez, Omar; Tuncel, Setenay

    2007-01-15

    The industrial revolution demonstrated the limitations of a pure mechanistic approach towards work design. Human work is now seen as a complex entity that involves different scientific branches and blurs the line between mental and physical activities. Job design has been a traditional concern of applied psychology, which has provided insight into the interaction between the individual and the work environment. The goal of this paper is to introduce the human-at-work system as a holistic approach to organizational design. It postulates that the well-being of workers and work outcomes are issues that need to be addressed jointly, moving beyond traditional concepts of job satisfaction and work stress. The work compatibility model (WCM) is introduced as an engineering approach that seeks to integrate previous constructs of job and organizational design. The WCM seeks a balance between energy expenditure and replenishment. The implementation of the WCM in industrial settings is described within the context of the Work Compatibility Improvement Framework. A sample review of six models (motivation-hygiene theory; job characteristics theory; person-environment fit; demand-control model; and balance theory) provides the foundation for the interaction between the individual and the work environment. A review of three workload assessment methods (position analysis questionnaire, job task analysis and NASA task load index) gives an example of the foundation for the taxonomy of work environment domains. Previous models have sought to identify a balance state for the human-at-work system. They differentiated between the objective and subjective effects of the environment and the worker. An imbalance between the person and the environment has been proven to increase health risks. The WCM works with a taxonomy of 12 work domains classified in terms of the direct (acting) or indirect (experienced) effect on the worker. In terms of measurement, two quantitative methods are proposed

  16. Design and fabrication of a sensor integrated MEMS/NANO-skin system for human physiological response measurement

    NASA Astrophysics Data System (ADS)

    Leng, Hongjie; Lin, Yingzi

    2010-04-01

    Human state in human-machine systems highly affects the system performance, and should be monitored. Physiological cues are more suitable for monitoring the human state in human-machine system. This study was focused on developing a new sensing system, i.e. NANO-Skin, to non-intrusively measure physiological cues from human-machine contact surfaces for human state recognition. The first part was to analyze the relation between human state and physiological cues. Generally, heart rate, skin conductance, skin temperature, operating force, blood alcohol concentration, sweat rate, and electromyography have close relation with human state, and can be measured from human skin. The second part was to compare common sensors, MEMS sensors, and NANO sensors. It was found that MEMS sensors and NANO sensors can offer unique contributions to the development of NANO-Skin. The third part was to discuss the design and manufacture of NANO-Skin. The NANO-Skin involves five components, the flexible substrate, sensors, special integrated circuit, interconnection between sensors and special integrated circuit, and protection layer. Experiments were performed to verify the measurement accuracy of NANO-Skin. It is feasible to use NANO-Skins to non-intrusively measure physiological cues from human-machine contact surfaces for human state recognition.

  17. Socio-Ecohydrologic Agents And Services: Integrating Human And Natural Components To Address Coupled System Resilience

    NASA Astrophysics Data System (ADS)

    Pavao-zuckerman, M.; Pope, A.; Chan, D.; Curl, K.; Gimblett, H. R.; Hough, M.; House-Peters, L.; Lee, R.; Scott, C. A.

    2012-12-01

    Riparian corridors in arid regions are highly valued for their relative scarcity, and because healthy riparian systems support high levels of biodiversity, can meet human demand for water and water-related resources and functions. Our team is taking a transdiciplinary social-ecological systems approach to assessing riparian corridor resilience in two watersheds (the San Pedro River in USA and Mexico, and the Rio San Miguel in Mexico) through a project funded by the NSF CNH program ("Strengthening Resilience of Arid Region Riparian Corridors"). Multiple perspectives are integrated in the project, including hydrology, ecology, institutional dynamics, and decision making (at the level of both policy and individual choice), as well as the perspectives of various stakeholder groups and individuals in the watersheds. Here we discuss initial findings that center around linking changes in ecohydrology and livelihoods related to decisions in response to climatic, ecological, and social change. The research team is implementing two approaches to integrate the disparate disciplines participating in the research (and the varied perspectives among the stakeholders in this binational riparian context): (1) ecosystem service assessment, and (2) agent based model simulation. We are developing an ecosystem service perspective that provides a bridge between ecological dynamics in the landscape and varied stakeholder perspectives on the implications of ecohydrology for well-being (economic, cultural, ecological). Services are linked on one hand to the spatial patterns of traits of individuals within species (allowing a more predictive application of ecosystem services as they vary with community change in time), and to stakeholder perspectives (facilitating integration of ecosystem services into our understanding of decision making processes) in a case study in the San Pedro River National Conservation Area. The agent- based model (ABM) approach incorporates the influence of human

  18. Postures and Motions Library Development for Verification of Ground Crew Human Systems Integration Requirements

    NASA Technical Reports Server (NTRS)

    Jackson, Mariea Dunn; Dischinger, Charles; Stambolian, Damon; Henderson, Gena

    2012-01-01

    Spacecraft and launch vehicle ground processing activities require a variety of unique human activities. These activities are being documented in a Primitive motion capture library. The Library will be used by the human factors engineering in the future to infuse real to life human activities into the CAD models to verify ground systems human factors requirements. As the Primitive models are being developed for the library the project has selected several current human factors issues to be addressed for the SLS and Orion launch systems. This paper explains how the Motion Capture of unique ground systems activities are being used to verify the human factors analysis requirements for ground system used to process the STS and Orion vehicles, and how the primitive models will be applied to future spacecraft and launch vehicle processing.

  19. Crew systems: integrating human and technical subsystems for the exploration of space

    NASA Technical Reports Server (NTRS)

    Connors, M. M.; Harrison, A. A.; Summit, J.

    1994-01-01

    Space exploration missions will require combining human and technical subsystems into overall "crew systems" capable of performing under the rigorous conditions of outer space. This report describes substantive and conceptual relationships among humans, intelligent machines, and communication systems, and explores how these components may be combined to complement and strengthen one another. We identify key research issues in the combination of humans and technology and examine the role of individual differences, group processes, and environmental conditions. We conclude that a crew system is, in effect, a social cyborg, a living system consisting of multiple individuals whose capabilities are extended by advanced technology.

  20. HPD: an online integrated human pathway database enabling systems biology studies

    PubMed Central

    2009-01-01

    Background Pathway-oriented experimental and computational studies have led to a significant accumulation of biological knowledge concerning three major types of biological pathway events: molecular signaling events, gene regulation events, and metabolic reaction events. A pathway consists of a series of molecular pathway events that link molecular entities such as proteins, genes, and metabolites. There are approximately 300 biological pathway resources as of April 2009 according to the Pathguide database; however, these pathway databases generally have poor coverage or poor quality, and are difficult to integrate, due to syntactic-level and semantic-level data incompatibilities. Results We developed the Human Pathway Database (HPD) by integrating heterogeneous human pathway data that are either curated at the NCI Pathway Interaction Database (PID), Reactome, BioCarta, KEGG or indexed from the Protein Lounge Web sites. Integration of pathway data at syntactic, semantic, and schematic levels was based on a unified pathway data model and data warehousing-based integration techniques. HPD provides a comprehensive online view that connects human proteins, genes, RNA transcripts, enzymes, signaling events, metabolic reaction events, and gene regulatory events. At the time of this writing HPD includes 999 human pathways and more than 59,341 human molecular entities. The HPD software provides both a user-friendly Web interface for online use and a robust relational database backend for advanced pathway querying. This pathway tool enables users to 1) search for human pathways from different resources by simply entering genes/proteins involved in pathways or words appearing in pathway names, 2) analyze pathway-protein association, 3) study pathway-pathway similarity, and 4) build integrated pathway networks. We demonstrated the usage and characteristics of the new HPD through three breast cancer case studies. Conclusion HPD http://bio.informatics.iupui.edu/HPD is a new

  1. Surface Support Systems for Co-Operative and Integrated Human/Robotic Lunar Exploration

    NASA Technical Reports Server (NTRS)

    Mueller, Robert P.

    2006-01-01

    Human and robotic partnerships to realize space goals can enhance space missions and provide increases in human productivity while decreasing the hazards that the humans are exposed to. For lunar exploration, the harsh environment of the moon and the repetitive nature of the tasks involved with lunar outpost construction, maintenance and operation as well as production tasks associated with in-situ resource utilization, make it highly desirable to use robotic systems in co-operation with human activity. A human lunar outpost is functionally examined and concepts for selected human/robotic tasks are discussed in the context of a lunar outpost which will enable the presence of humans on the moon for extended periods of time.

  2. Building Better Human Service Systems: Integrating Services for Income Support and Related Programs.

    ERIC Educational Resources Information Center

    Ragan, Mark

    Service integration attempts to provide coordinated service delivery systems for the uncoordinated mix of programs such as income support programs (food stamps, Medicaid, and Temporary Assistance for Needy Families) and employment, child care, child welfare, and training programs that exist at the local level throughout the United States by…

  3. PATHWAYS: A Human Support System Model for Integrated Handicapped Children and Their Families. Final Report.

    ERIC Educational Resources Information Center

    Carlson, Nancy A., Ed.

    The final report discusses achievements of a 3 year project to demonstrate the feasibility and effectiveness of integrating young handicapped children into existing early childhood programs. The project is conceptualized from a socioecological model, operationalized as a technical assistance support system, and located within an interdisciplinary…

  4. A 3D bioprinting system to produce human-scale tissue constructs with structural integrity.

    PubMed

    Kang, Hyun-Wook; Lee, Sang Jin; Ko, In Kap; Kengla, Carlos; Yoo, James J; Atala, Anthony

    2016-03-01

    A challenge for tissue engineering is producing three-dimensional (3D), vascularized cellular constructs of clinically relevant size, shape and structural integrity. We present an integrated tissue-organ printer (ITOP) that can fabricate stable, human-scale tissue constructs of any shape. Mechanical stability is achieved by printing cell-laden hydrogels together with biodegradable polymers in integrated patterns and anchored on sacrificial hydrogels. The correct shape of the tissue construct is achieved by representing clinical imaging data as a computer model of the anatomical defect and translating the model into a program that controls the motions of the printer nozzles, which dispense cells to discrete locations. The incorporation of microchannels into the tissue constructs facilitates diffusion of nutrients to printed cells, thereby overcoming the diffusion limit of 100-200 μm for cell survival in engineered tissues. We demonstrate capabilities of the ITOP by fabricating mandible and calvarial bone, cartilage and skeletal muscle. Future development of the ITOP is being directed to the production of tissues for human applications and to the building of more complex tissues and solid organs. PMID:26878319

  5. Development of an Integrated Human Factors Toolkit

    NASA Technical Reports Server (NTRS)

    Resnick, Marc L.

    2003-01-01

    An effective integration of human abilities and limitations is crucial to the success of all NASA missions. The Integrated Human Factors Toolkit facilitates this integration by assisting system designers and analysts to select the human factors tools that are most appropriate for the needs of each project. The HF Toolkit contains information about a broad variety of human factors tools addressing human requirements in the physical, information processing and human reliability domains. Analysis of each tool includes consideration of the most appropriate design stage, the amount of expertise in human factors that is required, the amount of experience with the tool and the target job tasks that are needed, and other factors that are critical for successful use of the tool. The benefits of the Toolkit include improved safety, reliability and effectiveness of NASA systems throughout the agency. This report outlines the initial stages of development for the Integrated Human Factors Toolkit.

  6. Step 1: Human System Integration (HSI) FY05 Pilot-Technology Interface Requirements for Command, Control, and Communications (C3)

    NASA Technical Reports Server (NTRS)

    2005-01-01

    The document provides the Human System Integration(HSI) high-level functional C3 HSI requirements for the interface to the pilot. Description includes (1) the information required by the pilot to have knowledge C3 system status, and (2) the control capability needed by the pilot to obtain C3 information. Fundamentally, these requirements provide the candidate C3 technology concepts with the necessary human-related elements to make them compatible with human capabilities and limitations. The results of the analysis describe how C3 operations and functions should interface with the pilot to provide the necessary C3 functionality to the UA-pilot system. Requirements and guidelines for C3 are partitioned into three categories: (1) Pilot-Air Traffic Control (ATC) Voice Communications (2) Pilot-ATC Data Communications, and (3) command and control of the unmanned aircraft (UA). Each requirement is stated and is supported with a rationale and associated reference(s).

  7. A new algorithm for integrated image quality measurement based on wavelet transform and human visual system

    NASA Astrophysics Data System (ADS)

    Wang, Haihui

    2006-01-01

    An essential determinant of the value of digital images is their quality. Over the past years, there have been many attempts to develop models or metrics for image quality that incorporate elements of human visual sensitivity. However, there is no current standard and objective definition of spectral image quality. This paper proposes a reliable automatic method for objective image quality measurement by wavelet transform and Human visual system. This way the proposed measure differentiates between the random and signal-dependant distortion, which have different effects on human observer. Performance of the proposed quality measure is illustrated by examples involving images with different types of degradation. The technique provides a means to relate the quality of an image to the interpretation and quantification throughout the frequency range, in which the noise level is estimated for quality evaluation. The experimental results of using this method for image quality measurement exhibit good correlation to subjective visual quality assessments.

  8. Integrating human and natural systems in community psychology: an ecological model of stewardship behavior.

    PubMed

    Moskell, Christine; Allred, Shorna Broussard

    2013-03-01

    Community psychology (CP) research on the natural environment lacks a theoretical framework for analyzing the complex relationship between human systems and the natural world. We introduce other academic fields concerned with the interactions between humans and the natural environment, including environmental sociology and coupled human and natural systems. To demonstrate how the natural environment can be included within CP's ecological framework, we propose an ecological model of urban forest stewardship action. Although ecological models of behavior in CP have previously modeled health behaviors, we argue that these frameworks are also applicable to actions that positively influence the natural environment. We chose the environmental action of urban forest stewardship because cities across the United States are planting millions of trees and increased citizen participation in urban tree planting and stewardship will be needed to sustain the benefits provided by urban trees. We used the framework of an ecological model of behavior to illustrate multiple levels of factors that may promote or hinder involvement in urban forest stewardship actions. The implications of our model for the development of multi-level ecological interventions to foster stewardship actions are discussed, as well as directions for future research to further test and refine the model. PMID:22722897

  9. Step 1:Human System Integration (HSI) FY05 Pilot-Technology Interface Requirements for Collision Avoidance

    NASA Technical Reports Server (NTRS)

    2007-01-01

    This document provides definition of technology human interface requirements for Collision Avoidance (CA). This was performed through a review of CA-related, HSI requirements documents, standards, and recommended practices. Technology concepts in use by the Access 5 CA work package were considered... Beginning with the HSI high-level functional requirement for CA, and CA technology elements, HSI requirements for the interface to the pilot were identified. Results of the analysis describe (1) the information required by the pilot to have knowledge CA system status, and (2) the control capability needed by the pilot to obtain CA information and affect an avoidance maneuver. Fundamentally, these requirements provide the candidate CA technology concepts with the necessary human-related elements to make them compatible with human capabilities and limitations. The results of the analysis describe how CA operations and functions should interface with the pilot to provide the necessary CA functionality to the UA-pilot system .Requirements and guidelines for CA are partitioned into four categories: (1) General, (2) Alerting, (3) Guidance, and (4) Cockpit Display of Traffic Information. Each requirement is stated and is supported with a rationale and associated reference(s).

  10. Human Exploration System Test-Bed for Integration and Advancement (HESTIA) Support of Future NASA Deep-Space Missions

    NASA Technical Reports Server (NTRS)

    Marmolejo, Jose; Ewert, Michael

    2016-01-01

    The Engineering Directorate at the NASA - Johnson Space Center is outfitting a 20-Foot diameter hypobaric chamber in Building 7 to support future deep-space Environmental Control & Life Support System (ECLSS) research as part of the Human Exploration System Test-bed for Integration and Advancement (HESTIA) Project. This human-rated chamber is the only NASA facility that has the unique experience, chamber geometry, infrastructure, and support systems capable of conducting this research. The chamber was used to support Gemini, Apollo, and SkyLab Missions. More recently, it was used to conduct 30-, 60-, and 90-day human ECLSS closed-loop testing in the 1990s to support the International Space Station and life support technology development. NASA studies show that both planetary surface and deep-space transit crew habitats will be 3-4 story cylindrical structures driven by human occupancy volumetric needs and launch vehicle constraints. The HESTIA facility offers a 3-story, 20-foot diameter habitat consistent with the studies' recommendations. HESTIA operations follow stringent processes by a certified test team that including human testing. Project management, analysis, design, acquisition, fabrication, assembly and certification of facility build-ups are available to support this research. HESTIA offers close proximity to key stakeholders including astronauts, Human Research Program (who direct space human research for the agency), Mission Operations, Safety & Mission Assurance, and Engineering Directorate. The HESTIA chamber can operate at reduced pressure and elevated oxygen environments including those proposed for deep-space exploration. Data acquisition, power, fluids and other facility resources are available to support a wide range of research. Recently completed HESTIA research consisted of unmanned testing of ECLSS technologies. Eventually, the HESTIA research will include humans for extended durations at reduced pressure and elevated oxygen to demonstrate

  11. Step 1: Human System Integration (HSI) FY05 Pilot-Technology Interface Requirements for Contingency Management

    NASA Technical Reports Server (NTRS)

    2005-01-01

    This document involves definition of technology interface requirements for Contingency Management. This was performed through a review of Contingency Management-related, HSI requirements documents, standards, and recommended practices. Technology concepts in use by the Contingency Management Work Package were considered. Beginning with HSI high-level functional requirements for Contingency Management, and Contingency Management technology elements, HSI requirements for the interface to the pilot were identified. Results of the analysis describe (1) the information required by the pilot to have knowledge of system failures and associated contingency procedures, and (2) the control capability needed by the pilot to obtain system status and procedure information. Fundamentally, these requirements provide the candidate Contingency Management technology concepts with the necessary human-related elements to make them compatible with human capabilities and limitations. The results of the analysis describe how Contingency Management operations and functions should interface with the pilot to provide the necessary Contingency Management functionality to the UA-pilot system. Requirements and guidelines for Contingency Management are partitioned into four categories: (1) Health and Status and (2) Contingency Management. Each requirement is stated and is supported with a rationale and associated reference(s).

  12. Uncovering the molecular machinery of the human spindle--an integration of wet and dry systems biology.

    PubMed

    Rojas, Ana M; Santamaria, Anna; Malik, Rainer; Jensen, Thomas Skøt; Körner, Roman; Morilla, Ian; de Juan, David; Krallinger, Martin; Hansen, Daniel Aaen; Hoffmann, Robert; Lees, Jonathan; Reid, Adam; Yeats, Corin; Wehner, Anja; Elowe, Sabine; Clegg, Andrew B; Brunak, Søren; Nigg, Erich A; Orengo, Christine; Valencia, Alfonso; Ranea, Juan A G

    2012-01-01

    The mitotic spindle is an essential molecular machine involved in cell division, whose composition has been studied extensively by detailed cellular biology, high-throughput proteomics, and RNA interference experiments. However, because of its dynamic organization and complex regulation it is difficult to obtain a complete description of its molecular composition. We have implemented an integrated computational approach to characterize novel human spindle components and have analysed in detail the individual candidates predicted to be spindle proteins, as well as the network of predicted relations connecting known and putative spindle proteins. The subsequent experimental validation of a number of predicted novel proteins confirmed not only their association with the spindle apparatus but also their role in mitosis. We found that 75% of our tested proteins are localizing to the spindle apparatus compared to a success rate of 35% when expert knowledge alone was used. We compare our results to the previously published MitoCheck study and see that our approach does validate some findings by this consortium. Further, we predict so-called "hidden spindle hub", proteins whose network of interactions is still poorly characterised by experimental means and which are thought to influence the functionality of the mitotic spindle on a large scale. Our analyses suggest that we are still far from knowing the complete repertoire of functionally important components of the human spindle network. Combining integrated bio-computational approaches and single gene experimental follow-ups could be key to exploring the still hidden regions of the human spindle system. PMID:22427808

  13. Integrated Modeling of the Human-Natural System to Improve Local Water Management and Planning

    NASA Astrophysics Data System (ADS)

    Gutowski, W. J., Jr.; Dziubanski, D.; Franz, K.; Goodwin, J.; Rehmann, C. R.; Simpkins, W. W.; Tesfastion, L.; Wanamaker, A. D.; Jie, Y.

    2015-12-01

    Communities across the world are experiencing the effects of unsustainable water management practices. Whether the problem is a lack of water, too much water, or water of degraded quality, finding acceptable solutions requires community-level efforts that integrate sound science with local needs and values. Our project develops both a software technology (agent-based hydrological modeling) and a social technology (a participatory approach to model development) that will allow communities to comprehensively address local water challenges. Using agent-based modeling (ABM), we are building a modeling system that includes a semi-distributed hydrologic process model coupled with agent (stakeholder) models. Information from the hydrologic model is conveyed to the agent models, which, along with economic information, determine appropriate agent actions that subsequently affect hydrology within the model. The iterative participatory modeling (IPM) process will assist with the continual development of the agent models. Further, IPM creates a learning environment in which all participants, including researchers, are co-exploring relevant data, possible scenarios and solutions, and viewpoints through continuous interactions. Our initial work focuses on the impact of flood mitigation and conservation efforts on reducing flooding in an urban area. We are applying all research elements above to the Squaw Creek watershed that flows through parts of four counties in central Iowa. The watershed offers many of the typical tensions encountered in Iowa, such as different perspectives on water management between upstream farmers and downstream urban areas, competition for various types of recreational services, and increasing absentee land ownership that may conflict with community values. Ultimately, climate change scenarios will be incorporated into the model to determine long term patterns that may develop within the social or natural system.

  14. Intelligent test integration system

    NASA Technical Reports Server (NTRS)

    Sztipanovits, J.; Padalkar, S.; Rodriguez-Moscoso, J.; Kawamura, K.; Purves, B.; Williams, R.; Biglari, H.

    1988-01-01

    A new test technology is described which was developed for space system integration. The ultimate purpose of the system is to support the automatic generation of test systems in real time, distributed computing environments. The Intelligent Test Integration System (ITIS) is a knowledge based layer above the traditional test system components which can generate complex test configurations from the specification of test scenarios.

  15. A Clinical Decision Support System for Integrating Tuberculosis and HIV Care in Kenya: A Human-Centered Design Approach

    PubMed Central

    Catalani, Caricia; Green, Eric; Owiti, Philip; Keny, Aggrey; Diero, Lameck; Yeung, Ada; Israelski, Dennis; Biondich, Paul

    2014-01-01

    With the aim of integrating HIV and tuberculosis care in rural Kenya, a team of researchers, clinicians, and technologists used the human-centered design approach to facilitate design, development, and deployment processes of new patient-specific TB clinical decision support system for medical providers. In Kenya, approximately 1.6 million people are living with HIV and have a 20-times higher risk of dying of tuberculosis. Although tuberculosis prevention and treatment medication is widely available, proven to save lives, and prioritized by the World Health Organization, ensuring that it reaches the most vulnerable communities remains challenging. Human-centered design, used in the fields of industrial design and information technology for decades, is an approach to improving the effectiveness and impact of innovations that has been scarcely used in the health field. Using this approach, our team followed a 3-step process, involving mixed methods assessment to (1) understand the situation through the collection and analysis of site observation sessions and key informant interviews; (2) develop a new clinical decision support system through iterative prototyping, end-user engagement, and usability testing; and, (3) implement and evaluate the system across 24 clinics in rural West Kenya. Through the application of this approach, we found that human-centered design facilitated the process of digital innovation in a complex and resource-constrained context. PMID:25170939

  16. Separate Brain Circuits Support Integrative and Semantic Priming in the Human Language System.

    PubMed

    Feng, Gangyi; Chen, Qi; Zhu, Zude; Wang, Suiping

    2016-07-01

    Semantic priming is a crucial phenomenon to study the organization of semantic memory. A novel type of priming effect, integrative priming, has been identified behaviorally, whereby a prime word facilitates recognition of a target word when the 2 concepts can be combined to form a unitary representation. We used both functional and anatomical imaging approaches to investigate the neural substrates supporting such integrative priming, and compare them with those in semantic priming. Similar behavioral priming effects for both semantic (Bread-Cake) and integrative conditions (Cherry-Cake) were observed when compared with an unrelated condition. However, a clearly dissociated brain response was observed between these 2 types of priming. The semantic-priming effect was localized to the posterior superior temporal and middle temporal gyrus. In contrast, the integrative-priming effect localized to the left anterior inferior frontal gyrus and left anterior temporal cortices. Furthermore, fiber tractography showed that the integrative-priming regions were connected via uncinate fasciculus fiber bundle forming an integrative circuit, whereas the semantic-priming regions connected to the posterior frontal cortex via separated pathways. The results point to dissociable neural pathways underlying the 2 distinct types of priming, illuminating the neural circuitry organization of semantic representation and integration. PMID:26209843

  17. Rapid detection and typing of live bacteria from human joint fluid samples by utilizing an integrated microfluidic system.

    PubMed

    Chang, Wen-Hsin; Wang, Chih-Hung; Lin, Chih-Lin; Wu, Jiunn-Jong; Lee, Mel S; Lee, Gwo-Bin

    2015-04-15

    Periprosthetic joint infection (PJI) is one of the most dreading complications that hinder the merits of an arthroplasty. A prerequisite for treatment of the above procedure is rapid detection of live bacteria to prevent its recurrence and proper choice of antibiotics. Conventional culture methods are time-consuming and associated with a high false negative rate. Amplification of bacterial genetic materials requires a tedious process but is associated with a high false positive rate. An integrated microfluidic system capable of molecular diagnosis for detecting live bacteria was reported in our previous work. However, the system could not provide detailed information about infectious bacteria for the subsequent antibiotic choices. Furthermore, it took at least 55min to finish the entire process. In this work, a microfluidic platform using ethidium monoazide (EMA) which can only penetrate into dead bacteria is presented for live bacteria detection and typing within a short period of time (30min for the detection of live bacteria and another 40min for the typing of bacteria strains). We tested the proposed system by using human joint fluid samples and found its limit of detection for bacterial detection equal to 10(2)CFU (colony formation unit) for live bacteria detection with gold nanoparticle probes and 10(2)-10(4)CFU for typing bacteria by an on-chip polymerase chain reaction. The whole procedure of the integrated microfluidic system is automated with little human intervention. Moreover, this is the first time that sequential live bacteria detection and typing are demonstrated on the same microfluidic platform. Based on the promising results, the proposed system may become in the near future an auxiliary tool for immediate medical decision and choice of antibiotics in routine arthroplasties or PJI's. PMID:25460896

  18. In-stream nitrate responses integrate human and climate systems in an intensively managed landscape

    NASA Astrophysics Data System (ADS)

    Ward, A. S.; Davis, C. A.; Burgin, A. J.; Loecke, T.; Riveros-Iregui, D. A.; Schnoebelen, D. J.; Just, C. L.; Thomas, S. A.; Weber, L. J.; St Clair, M. A.; Spak, S.; Dalrymple, K. E.; Li, Y.; Prior, K.

    2014-12-01

    Nitrogen (N) fertilization is a cornerstone of modern agriculture, but the practice also leads to eutrophication, hypoxia, and harmful algal blooms in both inland and coastal waters. Several studies identify Iowa, Illinois and Indiana as major source areas of N discharged by the Mississippi River to the Gulf of Mexico where large-scale hypoxia develops annually. Continental-scale management of nitrogen requires a comprehensive understanding of watershed-specific hydrologic dynamics and their consequences for nitrate flushing from agricultural landscapes. Spatiotemporal variation in nitrate fluxes is inherently complex due to the broad range of physicochemical and hydraulic properties that influence N movement through soils, groundwater, and rivers. In-stream N fluxes respond to both short- and long-term climactic forcing interacting with the cumulative human modification to both physical and biogeochemical systems in agricultural catchments. Here, we synthesize results from three individual studies in the Iowa River watershed. First, we demonstrate significant inter- and intra-annual variability in stream responses to rainfall events as a function of antecedent moisture conditions in three nested catchments (first through third-order). This study highlights the use of in-situ, high temporal resolution sensor networks as an emerging tool. Next, we leverage a catchment-wide synoptic study repeated in 2013 to demonstrate the landscape-scale impact of climate dynamics interacting with management decisions on the landscape. This study highlights the role of changes in extreme event frequency on water quality in agricultural landscapes. Finally, we extend results onto the landscape, using a numerical model to quantify heterogeneity of key controlling variables within the landscape (e.g., soil texture) and N retention or mobilization. We compare variability in key controls with variability driven by climate over a 60-yr period of record.

  19. Rapid isolation and diagnosis of live bacteria from human joint fluids by using an integrated microfluidic system.

    PubMed

    Chang, Wen-Hsin; Wang, Chih-Hung; Yang, Sung-Yi; Lin, Yi-Cheng; Wu, Jiunn-Jong; Lee, Mel S; Lee, Gwo-Bin

    2014-09-01

    Arthroplasty is a general approach for improving the life quality for patients with degenerative or injured joints. However, post-surgery complications including periprosthetic joint infection (PJI) poses a serious drawback to the procedure. Several methods are available for diagnosing PJI, but they are time-consuming or have poor sensitivity and specificity. Alternatively, reverse-transcription PCR can detect live bacteria and reduce false-positive results but cannot avoid the cumbersome RNA handling and human contamination issues. In response, an integrated microfluidic system capable of detecting live bacteria from clinical PJI samples within 55 minutes is developed in this study. This system employs an ethidium monoazide (EMA)-based assay and a PCR with universal bacterial primers and probes to isolate and detect only the live bacteria that commonly cause PJI. The experimental results indicated that the developed system can detect bacteria in human joint fluids with a detection limit of 10(4) colony formation unit mL(-1). Furthermore, nine clinical samples were analyzed using the microfluidic system. The results obtained from the microfluidic system were negative for all culture-negative cases, indicating that the proposed system can indeed reduce false-positive results. In addition, experimental results showed that the EMA sample pre-treatment process was crucial for successful detection of live bacteria. The culture-positive cases were diagnosed as positive by the proposed system only when the clinical samples were treated with EMA immediately after being sampled from patients. Based on these promising results, the developed microfluidic system can be a useful tool to detect PJI and potentially be applied in other clinical situations. PMID:25005800

  20. System integration report

    NASA Technical Reports Server (NTRS)

    Badler, N. I.; Korein, J. D.; Meyer, C.; Manoochehri, K.; Rovins, J.; Beale, J.; Barr, B.

    1985-01-01

    Several areas that arise from the system integration issue were examined. Intersystem analysis is discussed as it relates to software development, shared data bases and interfaces between TEMPUS and PLAID, shaded graphics rendering systems, object design (BUILD), the TEMPUS animation system, anthropometric lab integration, ongoing TEMPUS support and maintenance, and the impact of UNIX and local workstations on the OSDS environment.

  1. Avionics systems integration technology

    NASA Technical Reports Server (NTRS)

    Stech, George; Williams, James R.

    1988-01-01

    A very dramatic and continuing explosion in digital electronics technology has been taking place in the last decade. The prudent and timely application of this technology will provide Army aviation the capability to prevail against a numerically superior enemy threat. The Army and NASA have exploited this technology explosion in the development and application of avionics systems integration technology for new and future aviation systems. A few selected Army avionics integration technology base efforts are discussed. Also discussed is the Avionics Integration Research Laboratory (AIRLAB) that NASA has established at Langley for research into the integration and validation of avionics systems, and evaluation of advanced technology in a total systems context.

  2. Uncovering the Molecular Machinery of the Human Spindle—An Integration of Wet and Dry Systems Biology

    PubMed Central

    Körner, Roman; Morilla, Ian; de Juan, David; Krallinger, Martin; Hansen, Daniel Aaen; Hoffmann, Robert; Lees, Jonathan; Reid, Adam; Yeats, Corin; Wehner, Anja; Elowe, Sabine; Clegg, Andrew B.; Brunak, Søren; Nigg, Erich A.; Orengo, Christine; Valencia, Alfonso; Ranea, Juan A. G.

    2012-01-01

    The mitotic spindle is an essential molecular machine involved in cell division, whose composition has been studied extensively by detailed cellular biology, high-throughput proteomics, and RNA interference experiments. However, because of its dynamic organization and complex regulation it is difficult to obtain a complete description of its molecular composition. We have implemented an integrated computational approach to characterize novel human spindle components and have analysed in detail the individual candidates predicted to be spindle proteins, as well as the network of predicted relations connecting known and putative spindle proteins. The subsequent experimental validation of a number of predicted novel proteins confirmed not only their association with the spindle apparatus but also their role in mitosis. We found that 75% of our tested proteins are localizing to the spindle apparatus compared to a success rate of 35% when expert knowledge alone was used. We compare our results to the previously published MitoCheck study and see that our approach does validate some findings by this consortium. Further, we predict so-called “hidden spindle hub”, proteins whose network of interactions is still poorly characterised by experimental means and which are thought to influence the functionality of the mitotic spindle on a large scale. Our analyses suggest that we are still far from knowing the complete repertoire of functionally important components of the human spindle network. Combining integrated bio-computational approaches and single gene experimental follow-ups could be key to exploring the still hidden regions of the human spindle system. PMID:22427808

  3. Integrating Oracle Human Resources with Other Modules

    NASA Technical Reports Server (NTRS)

    Sparks, Karl; Shope, Shawn

    1998-01-01

    One of the most challenging aspects of implementing an enterprise-wide business system is achieving integration of the different modules to the satisfaction of diverse customers. The Jet Propulsion Laboratory's (JPL) implementation of the Oracle application suite demonstrates the need to coordinate Oracle Human Resources Management System (HRMS) decision across the Oracle modules.

  4. Multidisciplinary design optimization of a human occupied vehicle based on Bi-Level integrated system collaborative optimization

    NASA Astrophysics Data System (ADS)

    Zhao, Min; Cui, Wei-cheng; Li, Xiang

    2015-06-01

    The design of Human Occupied Vehicle (HOV) is a typical multidisciplinary problem, but heavily dependent on the experience of naval architects at present engineering design. In order to relieve the experience dependence and improve the design, a new Multidisciplinary Design Optimization (MDO) method "Bi-Level Integrated System Collaborative Optimization (BLISCO)" is applied to the conceptual design of an HOV, which consists of hull module, resistance module, energy module, structure module, weight module, and the stability module. This design problem is defined by 21 design variables and 23 constraints, and its objective is to maximize the ratio of payload to weight. The results show that the general performance of the HOV can be greatly improved by BLISCO.

  5. Small Unmanned Aircraft Systems Integration into the National Airspace System Visual-Line-of-Sight Human-in-the-Loop Experiment

    NASA Technical Reports Server (NTRS)

    Trujillo, Anna C.; Ghatas, Rania W.; Mcadaragh, Raymon; Burdette, Daniel W.; Comstock, James R.; Hempley, Lucas E.; Fan, Hui

    2015-01-01

    As part of the Unmanned Aircraft Systems (UAS) in the National Airspace System (NAS) project, research on integrating small UAS (sUAS) into the NAS was underway by a human-systems integration (HSI) team at the NASA Langley Research Center. Minimal to no research has been conducted on the safe, effective, and efficient manner in which to integrate these aircraft into the NAS. sUAS are defined as aircraft weighing 55 pounds or less. The objective of this human system integration team was to build a UAS Ground Control Station (GCS) and to develop a research test-bed and database that provides data, proof of concept, and human factors guidelines for GCS operations in the NAS. The objectives of this experiment were to evaluate the effectiveness and safety of flying sUAS in Class D and Class G airspace utilizing manual control inputs and voice radio communications between the pilot, mission control, and air traffic control. The design of the experiment included three sets of GCS display configurations, in addition to a hand-held control unit. The three different display configurations were VLOS, VLOS + Primary Flight Display (PFD), and VLOS + PFD + Moving Map (Map). Test subject pilots had better situation awareness of their vehicle position, altitude, airspeed, location over the ground, and mission track using the Map display configuration. This configuration allowed the pilots to complete the mission objectives with less workload, at the expense of having better situation awareness of other aircraft. The subjects were better able to see other aircraft when using the VLOS display configuration. However, their mission performance, as well as their ability to aviate and navigate, was reduced compared to runs that included the PFD and Map displays.

  6. Integrating the Advanced Human Eye Model (AHEM) and optical instrument models to model complete visual optical systems inclusive of the typical or atypical eye

    NASA Astrophysics Data System (ADS)

    Donnelly, William J., III

    2012-06-01

    PURPOSE: To present a commercially available optical modeling software tool to assist the development of optical instrumentation and systems that utilize and/or integrate with the human eye. METHODS: A commercially available flexible eye modeling system is presented, the Advanced Human Eye Model (AHEM). AHEM is a module that the engineer can use to perform rapid development and test scenarios on systems that integrate with the eye. Methods include merging modeled systems initially developed outside of AHEM and performing a series of wizard-type operations that relieve the user from requiring an optometric or ophthalmic background to produce a complete eye inclusive system. Scenarios consist of retinal imaging of targets and sources through integrated systems. Uses include, but are not limited to, optimization, telescopes, microscopes, spectacles, contact and intraocular lenses, ocular aberrations, cataract simulation and scattering, and twin eye model (binocular) systems. RESULTS: Metrics, graphical data, and exportable CAD geometry are generated from the various modeling scenarios.

  7. A study on airborne integrated display system and human information processing

    NASA Technical Reports Server (NTRS)

    Mizumoto, K.; Iwamoto, H.; Shimizu, S.; Kuroda, I.

    1983-01-01

    The cognitive behavior of pilots was examined in an experiment involving mock ups of an eight display electronic attitude direction indicator for an airborne integrated display. Displays were presented in digital, analog digital, and analog format to experienced pilots. Two tests were run, one involving the speed of memorization in a single exposure and the other comprising two five second exposures spaced 30 sec apart. Errors increased with the speed of memorization. Generally, the analog information was assimilated faster than the digital data, with regard to the response speed. Information processing was quantified as 25 bits for the first five second exposure and 15 bits during the second.

  8. Microfabricated Mammalian Organ Systems and Their Integration into Models of Whole Animals and Humans

    PubMed Central

    Sung, Jong H; Esch, Mandy B; Prot, Jean-Matthieu; Long, Christopher J; Smith, Alec; Hickman, James; Shuler, Michael L

    2013-01-01

    While in vitro cell based systems have been an invaluable tool in biology, they often suffer from a lack of physiological relevance. The discrepancy between the in vitro and in vivo systems has been a bottleneck in drug development process and biological sciences. The recent progress in microtechnology has enabled manipulation of cellular environment at a physiologically relevant length scale, which has led to the development of novel in vitro organ systems, often termed ‘organ-on-a-chip’ systems. By mimicking the cellular environment of in vivo tissues, various organ-on-a-chip systems have been reported to reproduce target organ functions better than conventional in vitro model systems. Ultimately, these organ-on-a-chip systems will converge into multi-organ ‘body-on-a-chip’ systems composed of functional tissues that reproduce the dynamics of the whole-body response. Such microscale in vitro systems will open up new possibilities in medical science and in the pharmaceutical industry. PMID:23388858

  9. Systems Integration (Fact Sheet)

    SciTech Connect

    DOE Solar Energy Technologies Program

    2011-10-13

    The Systems Integration (SI) subprogram works closely with industry, universities, and the national laboratories to overcome technical barriers to the large-scale deployment of solar technologies. To support these goals, the subprogram invests primarily in four areas: grid integration, technology validation, solar resource assessment, and balance of system development.

  10. Systems Integration (Fact Sheet)

    SciTech Connect

    Not Available

    2011-10-01

    The Systems Integration (SI) subprogram works closely with industry, universities, and the national laboratories to overcome technical barriers to the large-scale deployment of solar technologies. To support these goals, the subprogram invests primarily in four areas: grid integration, technology validation, solar resource assessment, and balance of system development.

  11. Academic Research Integration System

    ERIC Educational Resources Information Center

    Surugiu, Iula; Velicano, Manole

    2008-01-01

    This paper comprises results concluding the research activity done so far regarding enhanced web services and system integration. The objective of the paper is to define the software architecture for a coherent framework and methodology for enhancing existing web services into an integrated system. This document presents the research work that has…

  12. A Designated Odor–Language Integration System in the Human Brain

    PubMed Central

    Hurley, Robert S.; Bowman, Nicholas E.; Bao, Xiaojun; Mesulam, M.-Marsel; Gottfried, Jay A.

    2014-01-01

    Odors are surprisingly difficult to name, but the mechanism underlying this phenomenon is poorly understood. In experiments using event-related potentials (ERPs) and functional magnetic resonance imaging (fMRI), we investigated the physiological basis of odor naming with a paradigm where olfactory and visual object cues were followed by target words that either matched or mismatched the cue. We hypothesized that word processing would not only be affected by its semantic congruency with the preceding cue, but would also depend on the cue modality (olfactory or visual). Performance was slower and less precise when linking a word to its corresponding odor than to its picture. The ERP index of semantic incongruity (N400), reflected in the comparison of nonmatching versus matching target words, was more constrained to posterior electrode sites and lasted longer on odor-cue (vs picture-cue) trials. In parallel, fMRI cross-adaptation in the right orbitofrontal cortex (OFC) and the left anterior temporal lobe (ATL) was observed in response to words when preceded by matching olfactory cues, but not by matching visual cues. Time-series plots demonstrated increased fMRI activity in OFC and ATL at the onset of the odor cue itself, followed by response habituation after processing of a matching (vs nonmatching) target word, suggesting that predictive perceptual representations in these regions are already established before delivery and deliberation of the target word. Together, our findings underscore the modality-specific anatomy and physiology of object identification in the human brain. PMID:25378154

  13. Understanding coupled natural and human systems on fire prone landscapes: integrating wildfire simulation into an agent based planning system.

    NASA Astrophysics Data System (ADS)

    Barros, Ana; Ager, Alan; Preisler, Haiganoush; Day, Michelle; Spies, Tom; Bolte, John

    2015-04-01

    Agent-based models (ABM) allow users to examine the long-term effects of agent decisions in complex systems where multiple agents and processes interact. This framework has potential application to study the dynamics of coupled natural and human systems where multiple stimuli determine trajectories over both space and time. We used Envision, a landscape based ABM, to analyze long-term wildfire dynamics in a heterogeneous, multi-owner landscape in Oregon, USA. Landscape dynamics are affected by land management policies, actors decisions, and autonomous processes such as vegetation succession, wildfire, or at a broader scale, climate change. Key questions include: 1) How are landscape dynamics influenced by policies and institutions, and 2) How do land management policies and actor decisions interact to produce intended and unintended consequences with respect to wildfire on fire-prone landscapes. Applying Envision to address these questions required the development of a wildfire module that could accurately simulate wildfires on the heterogeneous landscapes within the study area in terms of replicating historical fire size distribution, spatial distribution and fire intensity. In this paper we describe the development and testing of a mechanistic fire simulation system within Envision and application of the model on a 3.2 million fire prone landscape in central Oregon USA. The core fire spread equations use the Minimum Travel Time algorithm developed by M Finney. The model operates on a daily time step and uses a fire prediction system based on the relationship between energy release component and historical fires. Specifically, daily wildfire probabilities and sizes are generated from statistical analyses of historical fires in relation to daily ERC values. The MTT was coupled with the vegetation dynamics module in Envision to allow communication between the respective subsystem and effectively model fire effects and vegetation dynamics after a wildfire. Canopy and

  14. Integrated design environment for human performance and human reliability analysis

    SciTech Connect

    Nelson, W.R.

    1997-05-01

    Work over the last few years at the Idaho National Engineering and Environmental Laboratory (INEEL) has included a major focus on applying human performance and human reliability knowledge and methods as an integral element of system design and development. This work has been pursued in programs in a wide variety of technical domains, beginning with nuclear power plant operations. Since the mid-1980`s the laboratory has transferred the methods and tools developed in the nuclear domain to military weapons systems and aircraft, offshore oil and shipping operations, and commercial aviation operations and aircraft design. Through these diverse applications the laboratory has developed an integrated approach and framework for application of human performance analysis, human reliability analysis (HRA), operational data analysis, and simulation studies of human performance to the design and development of complex systems. This approach was recently tested in the NASA Advanced Concepts Program {open_quotes}Structured Human Error Analysis for Aircraft Design.{close_quotes} This program resulted in the prototype software tool THEA (Tool for Human Error Analysis) for incorporating human error analysis in the design of commercial aircraft, focusing on airplane maintenance tasks. Current effort is directed toward applying this framework to the development of advanced Air Traffic Management (ATM) systems as part of NASA`s Advanced Air Transportation Technologies (AATT) program. This paper summarizes the approach, describes recent and current applications in commercial aviation, and provides perspectives on how the approach could be utilized in the nuclear power industry.

  15. Integrated Environmental Modelling: human decisions, human challenges

    USGS Publications Warehouse

    Glynn, Pierre D.

    2015-01-01

    Integrated Environmental Modelling (IEM) is an invaluable tool for understanding the complex, dynamic ecosystems that house our natural resources and control our environments. Human behaviour affects the ways in which the science of IEM is assembled and used for meaningful societal applications. In particular, human biases and heuristics reflect adaptation and experiential learning to issues with frequent, sharply distinguished, feedbacks. Unfortunately, human behaviour is not adapted to the more diffusely experienced problems that IEM typically seeks to address. Twelve biases are identified that affect IEM (and science in general). These biases are supported by personal observations and by the findings of behavioural scientists. A process for critical analysis is proposed that addresses some human challenges of IEM and solicits explicit description of (1) represented processes and information, (2) unrepresented processes and information, and (3) accounting for, and cognizance of, potential human biases. Several other suggestions are also made that generally complement maintaining attitudes of watchful humility, open-mindedness, honesty and transparent accountability. These suggestions include (1) creating a new area of study in the behavioural biogeosciences, (2) using structured processes for engaging the modelling and stakeholder communities in IEM, and (3) using ‘red teams’ to increase resilience of IEM constructs and use.

  16. Spaceflight Human System Standards

    NASA Technical Reports Server (NTRS)

    Holubec, Keith; Tillman, Barry; Connolly, Jan

    2009-01-01

    NASA created a new approach for human system integration and human performance standards. NASA created two documents a standard and a reference handbook. The standard is titled NASA Space Flight Human-System Standard (SFHSS) and consists of two-volumes: Volume 1- Crew Health This volume covers standards needed to support astronaut health (medical care, nutrition, sleep, exercise, etc.) Volume 2 Human Factors, Habitability and Environmental Health This volume covers the standards for system design that will maintain astronaut performance (ie., environmental factors, design of facilities, layout of workstations, and lighting requirements). It includes classic human factors requirements. The new standards document is written in terms so that it is applicable to a broad range of present and future NASA systems. The document states that all new programs prepare system-specific requirements that will meet the general standards. For example, the new standard does not specify a design should accommodate specific percentiles of a defined population. Rather, NASA-STD-3001, Volume 2 states that all programs shall prepare program-specific requirements that define the user population and their size ranges. The design shall then accommodate the full size range of those users. The companion reference handbook, Human Integration Design Handbook (HIDH), was developed to capture the design consideration information from NASA-STD-3000, and adds spaceflight lessons learned, gaps in knowledge, example solutions, and suggests research to further mature specific disciplines. The HIDH serves two major purposes: HIDH is the reference document for writing human factors requirements for specific systems. HIDH contains design guidance information that helps insure that designers create systems which safely and effectively accommodate the capabilities and limitations of space flight crews.

  17. Recent Progresses in Incorporating Human Land-Water Management into Global Land Surface Models Toward Their Integration into Earth System Models

    NASA Technical Reports Server (NTRS)

    Pokhrel, Yadu N.; Hanasaki, Naota; Wada, Yoshihide; Kim, Hyungjun

    2016-01-01

    The global water cycle has been profoundly affected by human land-water management. As the changes in the water cycle on land can affect the functioning of a wide range of biophysical and biogeochemical processes of the Earth system, it is essential to represent human land-water management in Earth system models (ESMs). During the recent past, noteworthy progress has been made in large-scale modeling of human impacts on the water cycle but sufficient advancements have not yet been made in integrating the newly developed schemes into ESMs. This study reviews the progresses made in incorporating human factors in large-scale hydrological models and their integration into ESMs. The study focuses primarily on the recent advancements and existing challenges in incorporating human impacts in global land surface models (LSMs) as a way forward to the development of ESMs with humans as integral components, but a brief review of global hydrological models (GHMs) is also provided. The study begins with the general overview of human impacts on the water cycle. Then, the algorithms currently employed to represent irrigation, reservoir operation, and groundwater pumping are discussed. Next, methodological deficiencies in current modeling approaches and existing challenges are identified. Furthermore, light is shed on the sources of uncertainties associated with model parameterizations, grid resolution, and datasets used for forcing and validation. Finally, representing human land-water management in LSMs is highlighted as an important research direction toward developing integrated models using ESM frameworks for the holistic study of human-water interactions within the Earths system.

  18. Integrating Data and Networks: Human Factors

    NASA Astrophysics Data System (ADS)

    Chen, R. S.

    2012-12-01

    The development of technical linkages and interoperability between scientific networks is a necessary but not sufficient step towards integrated use and application of networked data and information for scientific and societal benefit. A range of "human factors" must also be addressed to ensure the long-term integration, sustainability, and utility of both the interoperable networks themselves and the scientific data and information to which they provide access. These human factors encompass the behavior of both individual humans and human institutions, and include system governance, a common framework for intellectual property rights and data sharing, consensus on terminology, metadata, and quality control processes, agreement on key system metrics and milestones, the compatibility of "business models" in the short and long term, harmonization of incentives for cooperation, and minimization of disincentives. Experience with several national and international initiatives and research programs such as the International Polar Year, the Group on Earth Observations, the NASA Earth Observing Data and Information System, the U.S. National Spatial Data Infrastructure, the Global Earthquake Model, and the United Nations Spatial Data Infrastructure provide a range of lessons regarding these human factors. Ongoing changes in science, technology, institutions, relationships, and even culture are creating both opportunities and challenges for expanded interoperability of scientific networks and significant improvement in data integration to advance science and the use of scientific data and information to achieve benefits for society as a whole.

  19. Integrated Avionics System (IAS)

    NASA Technical Reports Server (NTRS)

    Hunter, D. J.

    2001-01-01

    As spacecraft designs converge toward miniaturization and with the volumetric and mass constraints placed on avionics, programs will continue to advance the 'state of the art' in spacecraft systems development with new challenges to reduce power, mass, and volume. Although new technologies have improved packaging densities, a total system packaging architecture is required that not only reduces spacecraft volume and mass budgets, but increase integration efficiencies, provide modularity and scalability to accommodate multiple missions. With these challenges in mind, a novel packaging approach incorporates solutions that provide broader environmental applications, more flexible system interconnectivity, scalability, and simplified assembly test and integration schemes. This paper will describe the fundamental elements of the Integrated Avionics System (IAS), Horizontally Mounted Cube (HMC) hardware design, system and environmental test results. Additional information is contained in the original extended abstract.

  20. Integrating Human Immunodeficiency Virus and Reproductive, Maternal and Child, and Tuberculosis Health Services Within National Health Systems.

    PubMed

    Joseph Davey, Dvora; Myer, Landon; Bukusi, Elizabeth; Ramogola-Masire, Doreen; Kilembe, William; Klausner, Jeffrey D

    2016-06-01

    Joint United Nations Programme on HIV/AIDS (UNAIDS) established 90-90-90 HIV treatment targets for 2020 including the following: 90 % of HIV-infected people know their HIV status, 90 % of HIV-infected people who know their status are on treatment, and 90 % of people on HIV treatment have a suppressed viral load. Integration of HIV and other programs into the national health system provides an important pathway to reach those targets. We examine the case for integrating HIV and other health services to ensure sustainability and improve health outcomes within national health systems. In this non-systematic review, we examined recent studies on integrating HIV, tuberculosis (TB), maternal-child health (MCH), and sexually transmitted infection (STI) programs. Existing evidence is limited about the effectiveness of integration of HIV and other services. Most studies found that service integration increased uptake of services, but evidence is mixed about the effect on health outcomes or quality of health services. More rigorous studies of different strategies to promote integration over a wider range of services and settings are needed. Research on how best to maximize benefits, including sustainability, of integrated services is necessary to help inform international and national policy. We recommend additional interventions to test how best to integrate HIV and MCH services, HIV and TB services, HIV testing and treatment, and STI testing and treatment. PMID:27221628

  1. Intelligent Human Tracking Based on Multimodal Integration

    NASA Astrophysics Data System (ADS)

    Nakamura, Keisuke; Nakadai, Kazuhiro; Asano, Futoshi; Nakajima, Hirofumi; Ince, Gökhan

    Localization and tracking of humans are essential research topics in robotics. In particular, Sound Source Localization (SSL) has been of great interest. Despite the numerous reported methods, SSL in a real environment had mainly three issues; robustness against noise with high power, no framework for selective listening to sound sources, and tracking of inactive and/or noisy sound sources. For the first issue, we extended Multiple SIgnal Classification by incorporating Generalized Eigen Value Decomposition (GEVD-MUSIC) so that it can deal with high power noise and can select target sound sources. For the second issue, we proposed Sound Source Identification (SSI) based on hierarchical Gaussian mixture models and integrated it with GEVD-MUSIC to realize a function to listen to a specific sound source according to the sort of the sound source. For the third issue, auditory and visual human tracking were integrated using particle filtering. These three techniques are integrated into an intelligent human tracking system. Experimental results showed that integration of SSL and SSI successfully achieved human tracking only by audition, and the audio-visual integration showed considerable improvement in tracking by compensating the loss of auditory or visual information.

  2. Modular integrated video system

    SciTech Connect

    Gaertner, K.J.; Heaysman, B.; Holt, R.; Sonnier, C.

    1986-01-01

    The Modular Integrated Video System (MIVS) is intended to provide a simple, highly reliable closed circuit television (CCTV) system capable of replacing the IAEA Twin Minolta Film Camera Systems in those safeguards facilities where mains power is readily available, and situations where it is desired to have the CCTV camera separated from the CCTV recording console. This paper describes the MIVS and the Program Plan which is presently being followed for the development, testing, and implementation of the system.

  3. Aviation Data Integration System

    NASA Technical Reports Server (NTRS)

    Kulkarni, Deepak; Wang, Yao; Windrem, May; Patel, Hemil; Keller, Richard

    2003-01-01

    During the analysis of flight data and safety reports done in ASAP and FOQA programs, airline personnel are not able to access relevant aviation data for a variety of reasons. We have developed the Aviation Data Integration System (ADIS), a software system that provides integrated heterogeneous data to support safety analysis. Types of data available in ADIS include weather, D-ATIS, RVR, radar data, and Jeppesen charts, and flight data. We developed three versions of ADIS to support airlines. The first version has been developed to support ASAP teams. A second version supports FOQA teams, and it integrates aviation data with flight data while keeping identification information inaccessible. Finally, we developed a prototype that demonstrates the integration of aviation data into flight data analysis programs. The initial feedback from airlines is that ADIS is very useful in FOQA and ASAP analysis.

  4. On Quantum Integrable Systems

    SciTech Connect

    Danilov, Viatcheslav; Nagaitsev, Sergei; /Fermilab

    2011-11-01

    Many quantum integrable systems are obtained using an accelerator physics technique known as Ermakov (or normalized variables) transformation. This technique was used to create classical nonlinear integrable lattices for accelerators and nonlinear integrable plasma traps. Now, all classical results are carried over to a nonrelativistic quantum case. In this paper we have described an extension of the Ermakov-like transformation to the Schroedinger and Pauli equations. It is shown that these newly found transformations create a vast variety of time dependent quantum equations that can be solved in analytic functions, or, at least, can be reduced to time-independent ones.

  5. Integrated work management system.

    SciTech Connect

    Williams, Edward J., Jr.; Henry, Karen Lynne

    2010-06-01

    Sandia National Laboratories develops technologies to: (1) sustain, modernize, and protect our nuclear arsenal (2) Prevent the spread of weapons of mass destruction; (3) Provide new capabilities to our armed forces; (4) Protect our national infrastructure; (5) Ensure the stability of our nation's energy and water supplies; and (6) Defend our nation against terrorist threats. We identified the need for a single overarching Integrated Workplace Management System (IWMS) that would enable us to focus on customer missions and improve FMOC processes. Our team selected highly configurable commercial-off-the-shelf (COTS) software with out-of-the-box workflow processes that integrate strategic planning, project management, facility assessments, and space management, and can interface with existing systems, such as Oracle, PeopleSoft, Maximo, Bentley, and FileNet. We selected the Integrated Workplace Management System (IWMS) from Tririga, Inc. Facility Management System (FMS) Benefits are: (1) Create a single reliable source for facility data; (2) Improve transparency with oversight organizations; (3) Streamline FMOC business processes with a single, integrated facility-management tool; (4) Give customers simple tools and real-time information; (5) Reduce indirect costs; (6) Replace approximately 30 FMOC systems and 60 homegrown tools (such as Microsoft Access databases); and (7) Integrate with FIMS.

  6. Systems Integration Challenges for a National Space Launch System

    NASA Technical Reports Server (NTRS)

    May, Todd A.

    2011-01-01

    System Integration was refined through the complexity and early failures experienced in rocket flight. System Integration encompasses many different viewpoints of the system development. System Integration must ensure consistency in development and operations activities. Human Space Flight tends toward large, complex systems. Understanding the system fs operational and use context is the guiding principle for System Integration: (1) Sizeable costs can be driven into systems by not fully understanding context (2). Adhering to the system context throughout the system fs life cycle is essential to maintaining efficient System Integration. System Integration exists within the System Architecture. Beautiful systems are simple in use and operation -- Block upgrades facilitate manageable steps in functionality evolution. Effective System Integration requires a stable system concept. Communication is essential to system simplicity

  7. Optical systems integrated modeling

    NASA Technical Reports Server (NTRS)

    Shannon, Robert R.; Laskin, Robert A.; Brewer, SI; Burrows, Chris; Epps, Harlan; Illingworth, Garth; Korsch, Dietrich; Levine, B. Martin; Mahajan, Vini; Rimmer, Chuck

    1992-01-01

    An integrated modeling capability that provides the tools by which entire optical systems and instruments can be simulated and optimized is a key technology development, applicable to all mission classes, especially astrophysics. Many of the future missions require optical systems that are physically much larger than anything flown before and yet must retain the characteristic sub-micron diffraction limited wavefront accuracy of their smaller precursors. It is no longer feasible to follow the path of 'cut and test' development; the sheer scale of these systems precludes many of the older techniques that rely upon ground evaluation of full size engineering units. The ability to accurately model (by computer) and optimize the entire flight system's integrated structural, thermal, and dynamic characteristics is essential. Two distinct integrated modeling capabilities are required. These are an initial design capability and a detailed design and optimization system. The content of an initial design package is shown. It would be a modular, workstation based code which allows preliminary integrated system analysis and trade studies to be carried out quickly by a single engineer or a small design team. A simple concept for a detailed design and optimization system is shown. This is a linkage of interface architecture that allows efficient interchange of information between existing large specialized optical, control, thermal, and structural design codes. The computing environment would be a network of large mainframe machines and its users would be project level design teams. More advanced concepts for detailed design systems would support interaction between modules and automated optimization of the entire system. Technology assessment and development plans for integrated package for initial design, interface development for detailed optimization, validation, and modeling research are presented.

  8. Evaluation of Adverse Drug Properties with Cryopreserved Human Hepatocytes and the Integrated Discrete Multiple Organ Co-culture (IdMOCTM) System

    PubMed Central

    2015-01-01

    Human hepatocytes, with complete hepatic metabolizing enzymes, transporters and cofactors, represent the gold standard for in vitro evaluation of drug metabolism, drug-drug interactions, and hepatotoxicity. Successful cryopreservation of human hepatocytes enables this experimental system to be used routinely. The use of human hepatocytes to evaluate two major adverse drug properties: drug-drug interactions and hepatotoxicity, are summarized in this review. The application of human hepatocytes in metabolism-based drug-drug interaction includes metabolite profiling, pathway identification, P450 inhibition, P450 induction, and uptake and efflux transporter inhibition. The application of human hepatocytes in toxicity evaluation includes in vitro hepatotoxicity and metabolism-based drug toxicity determination. A novel system, the Integrated Discrete Multiple Organ Co-culture (IdMOC) which allows the evaluation of nonhepatic toxicity in the presence of hepatic metabolism, is described. PMID:26191380

  9. Integrated system design report

    SciTech Connect

    Not Available

    1989-07-01

    The primary objective of the integrated system test phase is to demonstrate the commercial potential of a coal fueled diesel engine in its actual operating environment. The integrated system in this project is defined as a coal fueled diesel locomotive. This locomotive, shown on drawing 41D715542, is described in the separate Concept Design Report. The test locomotive will be converted from an existing oil fueled diesel locomotive in three stages, until it nearly emulates the concept locomotive. Design drawings of locomotive components (diesel engine, locomotive, flatcar, etc.) are included.

  10. Firefighters Integrated Response Equipment System

    NASA Technical Reports Server (NTRS)

    Kaplan, H.; Abeles, F.

    1978-01-01

    The Firefighters Integrated Response Equipment System (Project FIRES) is a joint National Fire Prevention and Control Administration (NFPCA)/National Aeronautics and Space Administration (NASA) program for the development of an 'ultimate' firefighter's protective ensemble. The overall aim of Project FIRES is to improve firefighter protection against hazards, such as heat, flame, smoke, toxic fumes, moisture, impact penetration, and electricity and, at the same time, improve firefighter performance by increasing maneuverability, lowering weight, and improving human engineering design of his protective ensemble.

  11. Motor-Auditory-Visual Integration: The Role of the Human Mirror Neuron System in Communication and Communication Disorders

    ERIC Educational Resources Information Center

    Le Bel, Ronald M.; Pineda, Jaime A.; Sharma, Anu

    2009-01-01

    The mirror neuron system (MNS) is a trimodal system composed of neuronal populations that respond to motor, visual, and auditory stimulation, such as when an action is performed, observed, heard or read about. In humans, the MNS has been identified using neuroimaging techniques (such as fMRI and mu suppression in the EEG). It reflects an…

  12. INTEGRITY -- Integrated Human Exploration Mission Simulation Facility

    NASA Astrophysics Data System (ADS)

    Henninger, D.; Tri, T.; Daues, K.

    It is proposed to develop a high -fidelity ground facil ity to carry out long-duration human exploration mission simulations. These would not be merely computer simulations - they would in fact comprise a series of actual missions that just happen to stay on earth. These missions would include all elements of an actual mission, using actual technologies that would be used for the real mission. These missions would also include such elements as extravehicular activities, robotic systems, telepresence and teleoperation, surface drilling technology--all using a simulated planetary landscape. A sequence of missions would be defined that get progressively longer and more robust, perhaps a series of five or six missions over a span of 10 to 15 years ranging in durat ion from 180 days up to 1000 days. This high-fidelity ground facility would operate hand-in-hand with a host of other terrestrial analog sites such as the Antarctic, Haughton Crater, and the Arizona desert. Of course, all of these analog mission simulations will be conducted here on earth in 1-g, and NASA will still need the Shuttle and ISS to carry out all the microgravity and hypogravity science experiments and technology validations. The proposed missions would have sufficient definition such that definitive requirements could be derived from them to serve as direction for all the program elements of the mission. Additionally, specific milestones would be established for the "launch" date of each mission so that R&D programs would have both good requirements and solid milestones from which to build their implementation plans. Mission aspects that could not be directly incorporated into the ground facility would be simulated via software. New management techniques would be developed for evaluation in this ground test facility program. These new techniques would have embedded metrics which would allow them to be continuously evaluated and adjusted so that by the time the sequence of missions is completed

  13. Power systems integration

    SciTech Connect

    Brantley, L.W.

    1982-06-01

    Power systems integration in large flexible space structures is discussed with emphasis upon body control. A solar array is discussed as a typical example of spacecraft configuration problems. Information on how electric batteries dominate life-cycle costs is presented in chart form. Information is given on liquid metal droplet generators and collectors, hot spot analysis, power dissipation in solar arrays, solar array protection optimization, and electromagnetic compatibility for a power system platform.

  14. The `What is a system' reflection interview as a knowledge integration activity for high school students' understanding of complex systems in human biology

    NASA Astrophysics Data System (ADS)

    Tripto, Jaklin; Ben-Zvi Assaraf, Orit; Snapir, Zohar; Amit, Miriam

    2016-03-01

    This study examined the reflection interview as a tool for assessing and facilitating the use of 'systems language' amongst 11th grade students who have recently completed their first year of high school biology. Eighty-three students composed two concept maps in the 10th grade-one at the beginning of the school year and one at its end. The first part of the interview is dedicated to guiding the students through comparing their two concept maps and by means of both explicit and non-explicit teaching. Our study showed that the explicit guidance in comparing the two concept maps was more effective than the non-explicit, eliciting a variety of different, more specific, types of interactions and patterns (e.g. 'hierarchy', 'dynamism', 'homeostasis') in the students' descriptions of the human body system. The reflection interview as a knowledge integration activity was found to be an effective tool for assessing the subjects' conceptual models of 'system complexity', and for identifying those aspects of a system that are most commonly misunderstood.

  15. INTEGRITY - Integrated Human Exploration Mission Simulation Facility

    NASA Technical Reports Server (NTRS)

    Henninger, Donald L.

    2002-01-01

    It is proposed to develop a high-fidelity ground facility to carry out long-duration human exploration mission simulations. These would not be merely computer simulations - they would in fact comprise a series of actual missions that just happen to stay on earth. These missions would include all elements of an actual mission, using actual technologies that would be used for the real mission. These missions would also include such elements as extravehicular activities, robotic systems, telepresence and teleoperation, surface drilling technology-all using a simulated planetary landscape. A sequence of missions would be defined that get progressively longer and more robust, perhaps a series of five or six missions over a span of 10 to 15 years ranging in duration from 180 days up to 1000 days. This high-fidelity ground facility would operate hand-in-hand with a host of other terrestrial analog sites such as the Antarctic, Haughton Crater, and the Arizona desert. Of course, all of these analog mission simulations will be conducted here on earth in 1-g, and NASA will still need the Shuttle and ISS to carry out all the microgravity and hypogravity science experiments and technology validations. The proposed missions would have sufficient definition such that definitive requirements could be derived from them to serve as direction for all the program elements of the mission. Additionally, specific milestones would be established for the "launch" date of each mission so that R&D programs would have both good requirements and solid milestones from which to .build their implementation plans. Mission aspects that could not be directly incorporated into the ground facility would be simulated via software. New management techniques would be developed for evaluation in this ground test facility program. These new techniques would have embedded metrics which would allow them to be continuously evaluated and adjusted so that by the time the sequence of missions is completed, the

  16. Integrated oxygen recovery system

    NASA Technical Reports Server (NTRS)

    Lee, M. Gene; Davenport, Ronald J.

    1993-01-01

    Life Systems has conceptualized an innovative Integrated Oxygen Recovery System (IORS) applicable to advanced mission air revitalization. The IORS provides the capability to electrochemically generate metabolic oxygen (O2) and recover O2 from the space habitat atmosphere via a carbon dioxide (CO2) reduction process within a single assembly. To achieve this capability, the IORS utilizes a Solid Metal Cathode (SMC) water electrolysis unit that simultaneously serves as the Sabatier CO2 reduction reactor. The IORS enables two major life support systems currently baselined in closed loop air revitalization systems to be combined into one smaller, less complex system. This concept reduces fluidic and electrical interface requirements and eliminates a hydrogen (H2) interface. Life Systems is performing an evaluation of the IORS process directed at demonstrating performance and quantifying key physical characteristics including power, weight, and volume. The results of the checkout, shakedown, and initial parametric tests are summarized.

  17. Integrated oxygen recovery system

    NASA Technical Reports Server (NTRS)

    Lee, M. Gene; Davenport, Ronald J.

    1993-01-01

    Life Systems has conceptualized an innovative Integrated Oxygen Recovery System (IORS) applicable to advanced mission air revitalization. The IORS provides the capability to electrochemically generate metabolic oxygen (O2) and recover O2 from the space habitat atmosphere via a carbon dioxide (CO2) reduction process within a single assembly. To achieve this capability, the IORS utilizes a Solid Metal Cathode (SMC) water electrolysis unit that simultaneously serves as the Sabatier CO2 reduction reactor. The IORS enables two major life support systems currently baselined in closed loop air revitalization systems to be combined into one smaller, less complex system. This concept reduces fluidic and electrical interface requirements and eliminates a hydrogen (H2) interface. Life Systems is performing an evaluation of the IORS process directed at demonstrating performance and quantifying key physical characteristics including power, weight, and volume. Technical progress achieved during the first two months of the program is summarized.

  18. Integrating and Interfacing Library Systems.

    ERIC Educational Resources Information Center

    Boss, Richard W.

    1985-01-01

    This overview of local library online systems that integrate several functions covers functional integration, benefits of integrated systems, turnkey systems, minicomputer and microcomputer-based systems, interfacing automated systems, types of interfaces, linking homogenous and heterogeneous systems, role of vendors, library applications, linking…

  19. [Regional integration, population health needs, and human resources for health systems and services: an approach to the concept of health care gap].

    PubMed

    Schweiger, Arturo Luis Francisco; Alvarez, Daniela Teresita

    2007-01-01

    The existence of gaps between the population's health needs and the human resources available for meeting them, as well as limitations in the methods to estimate such needs, constitute key factors to be tackled in the development and integration of health systems in Latin America. This aim of this study was to conduct an initial literature review on the tools and procedures used to estimate and plan human resources allocation in health and to use this review as the basis for identifying the advantages, limitations, and complementary characteristics of these tools, subsequently proposing the need for more in-depth studies on their applicability for designing regional health policies. The article then presents the concept of global public health goods, the generation and use of which results in a strategic alternative for improving both health systems integration in the region and quality of life for the population covered by such services. PMID:17625647

  20. NASA Space Flight Human System Standards

    NASA Technical Reports Server (NTRS)

    Tillman, Barry; Pickett, Lynn; Russo, Dane; Stroud, Ken; Connolly, Jan; Foley, Tico

    2007-01-01

    NASA has begun a new approach to human factors design standards. For years NASA-STD-3000, Manned Systems Integration Standards, has been a source of human factors design guidance for space systems. In order to better meet the needs of the system developers, NASA is revising its human factors standards system. NASA-STD-3000 will be replaced by two documents: set of broad human systems specifications (including both human factors and medical topics) and a human factors design handbook

  1. Slimplectic Integrators: Variational Integrators for Nonconservative systems

    NASA Astrophysics Data System (ADS)

    Tsang, David

    2016-05-01

    Symplectic integrators are widely used for long-term integration of conservative astrophysical problems due to their ability to preserve the constants of motion; however, they cannot in general be applied in the presence of nonconservative interactions. Here we present the “slimplectic” integrator, a new type of numerical integrator that shares many of the benefits of traditional symplectic integrators yet is applicable to general nonconservative systems. We utilize a fixed-time-step variational integrator formalism applied to a newly developed principle of stationary nonconservative action (Galley, 2013, Galley et al 2014). As a result, the generalized momenta and energy (Noether current) evolutions are well-tracked. We discuss several example systems, including damped harmonic oscillators, Poynting–Robertson drag, and gravitational radiation reaction, by utilizing our new publicly available code to demonstrate the slimplectic integrator algorithm. Slimplectic integrators are well-suited for integrations of systems where nonconservative effects play an important role in the long-term dynamical evolution. As such they are particularly appropriate for cosmological or celestial N-body dynamics problems where nonconservative interactions, e.g., gas interactions or dissipative tides, can play an important role.

  2. Slimplectic Integrators: Variational Integrators for Nonconservative systems

    NASA Astrophysics Data System (ADS)

    Tsang, David

    2016-01-01

    Symplectic integrators are widely used for long-term integration of conservative astrophysical problems due to their ability to preserve the constants of motion; however, they cannot in general be applied in the presence of nonconservative interactions. In this Letter, we develop the "slimplectic" integrator, a new type of numerical integrator that shares many of the benefits of traditional symplectic integrators yet is applicable to general nonconservative systems. We utilize a fixed-time-step variational integrator formalism applied to the principle of stationary nonconservative action developed in Galley et al. As a result, the generalized momenta and energy (Noether current) evolutions are well-tracked. We discuss several example systems, including damped harmonic oscillators, Poynting-Robertson drag, and gravitational radiation reaction, by utilizing our new publicly available code to demonstrate the slimplectic integrator algorithm. Slimplectic integrators are well-suited for integrations of systems where nonconservative effects play an important role in the long-term dynamical evolution. As such they are particularly appropriate for cosmological or celestial N-body dynamics problems where nonconservative interactions, e.g., gas interactions or dissipative tides, can play an important role.

  3. Integrating Human Performance and Technology

    SciTech Connect

    Ronald K. Farris; Heather Medema

    2012-05-01

    Human error is a significant factor in the cause and/or complication of events that occur in the commercial nuclear industry. In recent years, great gains have been made using Human Performance (HU) tools focused on targeting individual behaviors. However, the cost of improving HU is growing and resistance to add yet another HU tool certainly exists, particularly for those tools that increase the paperwork for operations. Improvements in HU that are the result of leveraging existing technology, such as hand-held mobile technologies, have the potential to reduce human error in controlling system configurations, safety tag-outs, and other verifications. Operator rounds, valve line-up verifications, containment closure verifications, safety & equipment protection, and system tagging can be supported by field-deployable wireless technologies. These devices can also support the availability of critical component data in the main control room and other locations. This research pilot project reviewing wireless hand-held technology is part of the Light Water Reactor Sustainability Program (LWRSP), a research and development (R&D) program sponsored by the U. S. Department of Energy (DOE). The project is being performed in close collaboration with industry R&D programs to provide the technical foundations for licensing, and managing the long-term, safe, and economical operation of current nuclear power plants. The LWRSP vision is to develop technologies and other solutions that can improve the reliability, sustain the safety, and extend the life of the current nuclear reactor fleet.

  4. INTEGRATING ECOLOGY, HUMAN HEALTH AND SOCIOECONOMICS

    EPA Science Inventory

    This research involves collaboration with other ORD Labs and Centers, as well as external collaborators, to foster integration of assessment approaches used to evaluate human health and ecological risks and to demonstrate integrated environmental socioeconomic approaches. Part...

  5. Integrated traffic system

    SciTech Connect

    Creighton, H. ); Allen, R.; Stewart, S.; Hayto, S. )

    1990-11-01

    The traffic congestion on our roads today is becoming a critical problem. There is increased fuel consumption as cars wait along poorly timed arterials. Safety is threatened as poor traffic flow leads to collisions. This paper reports that Transport Canada and the Ministry of Transportation Ontario has developed an integrated traffic system (ITS). The system is designed to enable the optimization of traffic flow on existing roadways. The ITS system contains a data-base management system for traffic data (including accidents, roadway volumes, and signal timing details) and links this data base to the traffic analysis programs. This will ease the data management situation within the municipalities and standardize the traffic operations and reduce duplication of computerization development efforts.

  6. Integrated Aeropropulsion Control System Design

    NASA Technical Reports Server (NTRS)

    Lin, C. -F.; Hurley, Francis X.; Huang, Jie; Hadaegh, F. Y.

    1996-01-01

    %T Integrated Aeropropulsion Control System Design%A C-F. Lin%A Francis X. Hurley%A Jie Huang%A F. Y. Hadaegh%J International Conference on Control and Information(psi)995%C Hong Kong%D June 1995%K aeropropulsion, control, system%U http://jpltrs.jpl.nasa.gov/1995/95-0658.pdfAn integrated intelligent control approach is proposed to design a high performance control system for aeropropulsion systems based on advanced sensor processing, nonlinear control and neural fuzzy control integration. Our approach features the following innovations:??e complexity and uncertainty issues are addressed via the distributed parallel processing, learning, and online reoptimization properties of neural networks.??e nonlinear dynamics and the severe coupling can be naturally incorporated into the design framework.??e knowledge base and decision making logic furnished by fuzzy systems leads to a human intelligence enhanced control scheme.In addition, fault tolerance, health monitoring and reconfigurable control strategies will be accommodated by this approach to ensure stability, graceful degradation and reoptimization in the case of failures, malfunctions and damage.!.

  7. Integrated cellular systems

    NASA Astrophysics Data System (ADS)

    Harper, Jason C.

    integrate cells and direct their behaviors. This process permits, for the first time, the selection and in situ isolation of a single target cell from a population of cells with mixed phenotypes, and the subsequent monitoring of its behavior, and that of its progeny, under well defined conditions. These techniques promise a new means to integrate biomolecules with nanostructures and macroscale systems, and to manipulate cellular behavior at the individual cell level, having significant implications towards development of practical and robust integrated cellular systems.

  8. The hippocampus is an integral part of the temporal limbic system during emotional processing. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    NASA Astrophysics Data System (ADS)

    Trost, Wiebke; Frühholz, Sascha

    2015-06-01

    The proposed quartet theory of human emotions by Koelsch and colleagues [1] identifies four different affect systems to be involved in the processing of particular types of emotions. Moreover, the theory integrates both basic emotions and more complex emotion concepts, which include also aesthetic emotions such as musical emotions. The authors identify a particular brain system for each kind of emotion type, also by contrasting them to brain structures that are generally involved in emotion processing irrespective of the type of emotion. A brain system that has been less regarded in emotion theories, but which represents one of the four systems of the quartet to induce attachment related emotions, is the hippocampus.

  9. The Integral System

    PubMed Central

    2011-01-01

    The Integral System is a total care management system based on the Integral Theory which states ‘prolapse and symptoms of urinary stress, urge, abnormal bowel & bladder emptying, and some forms of pelvic pain, mainly arise, for different reasons, from laxity in the vagina or its supporting ligaments, a result of altered connective tissue’. Normal function The organs are suspended by ligaments against which muscles contract to open or close the their outlet tubes, urethra and anus. These ligaments fall naturally into a three-zone zone classification, anterior, middle, and posterior. Dysfunction Damaged ligaments weaken the force of muscle contraction, causing prolapse and abnormal bladder and bowel symptoms Diagnosis A pictorial diagnostic algorithm relates specific symptoms to damaged ligaments in each zone. Treatment In mild cases, new pelvic floor muscle exercises based on a squatting principle strengthen the natural closure muscles and their ligamentous insertions, thereby improving the symptoms predicted by the Theory. With more severe cases, polypropylene tapes applied through “keyhole” incision using special instruments reinforce the damaged ligaments, restoring structure and function. Problems that can be potentially addressed by application of the Integral System Urinary stress incontinenceUrinary urge incontinenceAbnormal bladder emptyingFacal incontinence and “obstructed evacuation” (“constipation”)Pelvic pain, and some types of vulvodynia and interstitial cystitisOrgan prolapse Conclusions Organ prolapse and symptoms are related, and both are mainly caused by laxity in the four main suspensory ligaments and perineal body. Restoration of ligament/fascial length and tension is required to restore anatomy and function. PMID:24578877

  10. C5a alters blood–brain barrier integrity in a human in vitro model of systemic lupus erythematosus

    PubMed Central

    Mahajan, Supriya D; Parikh, Neil U; Woodruff, Trent M; Jarvis, James N; Lopez, Molly; Hennon, Teresa; Cunningham, Patrick; Quigg, Richard J; Schwartz, Stanley A; Alexander, Jessy J

    2015-01-01

    The blood–brain barrier (BBB) plays a crucial role in brain homeostasis, thereby maintaining the brain environment precise for optimal neuronal function. Its dysfunction is an intriguing complication of systemic lupus erythematosus (SLE). SLE is a systemic autoimmune disorder where neurological complications occur in 5–50% of cases and is associated with impaired BBB integrity. Complement activation occurs in SLE and is an important part of the clinical profile. Our earlier studies demonstrated that C5a generated by complement activation caused the loss of brain endothelial layer integrity in rodents. The goal of the current study was to determine the translational potential of these studies to a human system. To assess this, we used a two dimensional in vitro BBB model constructed using primary human brain microvascular endothelial cells and astroglial cells, which closely emulates the in vivo BBB allowing the assessment of BBB integrity. Increased permeability monitored by changes in transendothelial electrical resistance and cytoskeletal remodelling caused by actin fiber rearrangement were observed when the cells were exposed to lupus serum and C5a, similar to the observations in mice. In addition, our data show that C5a/C5aR1 signalling alters nuclear factor-κB translocation into nucleus and regulates the expression of the tight junction proteins, claudin-5 and zonula occludens 1 in this setting. Our results demonstrate for the first time that C5a regulates BBB integrity in a neuroinflammatory setting where it affects both endothelial and astroglial cells. In addition, we also demonstrate that our previous findings in a mouse model, were emulated in human cells in vitro, bringing the studies one step closer to understanding the translational potential of C5a/C5aR1 blockade as a promising therapeutic strategy in SLE and other neurodegenerative diseases. PMID:26059553

  11. Development of a Human Motor Model for the Evaluation of an Integrated Alerting and Notification Flight Deck System

    NASA Technical Reports Server (NTRS)

    Daiker, Ron; Schnell, Thomas

    2010-01-01

    A human motor model was developed on the basis of performance data that was collected in a flight simulator. The motor model is under consideration as one component of a virtual pilot model for the evaluation of NextGen crew alerting and notification systems in flight decks. This model may be used in a digital Monte Carlo simulation to compare flight deck layout design alternatives. The virtual pilot model is being developed as part of a NASA project to evaluate multiple crews alerting and notification flight deck configurations. Model parameters were derived from empirical distributions of pilot data collected in a flight simulator experiment. The goal of this model is to simulate pilot motor performance in the approach-to-landing task. The unique challenges associated with modeling the complex dynamics of humans interacting with the cockpit environment are discussed, along with the current state and future direction of the model.

  12. Integrated Extravehicular Activity Human Research Plan: 2016

    NASA Technical Reports Server (NTRS)

    Abercromby, Andrew F. J.; Ross, Amy J.; Cupples, J. Scott; Rajulu, Sudhakar; Norcross, Jason R.; Chappell, Steven P.

    2016-01-01

    Multiple organizations within NASA and outside of NASA fund and participate in research related to extravehicular activity (EVA). In October 2015, representatives of the EVA Office, the Crew and Thermal Systems Division (CTSD), and the Human Research Program (HRP) at NASA Johnson Space Center agreed on a formal framework to improve multi-year coordination and collaboration in EVA research. At the core of the framework is an Integrated EVA Human Research Plan and a process by which it will be annually reviewed and updated. The over-arching objective of the collaborative framework is to conduct multi-disciplinary cost-effective research that will enable humans to perform EVAs safely, effectively, comfortably, and efficiently, as needed to enable and enhance human space exploration missions. Research activities must be defined, prioritized, planned and executed to comprehensively address the right questions, avoid duplication, leverage other complementary activities where possible, and ultimately provide actionable evidence-based results in time to inform subsequent tests, developments and/or research activities. Representation of all appropriate stakeholders in the definition, prioritization, planning and execution of research activities is essential to accomplishing the over-arching objective. A formal review of the Integrated EVA Human Research Plan will be conducted annually. External peer review of all HRP EVA research activities including compilation and review of published literature in the EVA Evidence Report is will also continue at a frequency determined by HRP management. Coordination with stakeholders outside of the EVA Office, CTSD, and HRP is already in effect on a study-by-study basis; closer coordination on multi-year planning with other EVA stakeholders including academia is being actively pursued. Details of the current Integrated EVA Human Research Plan are presented including description of ongoing and planned research activities in the areas of

  13. Building a Formal Model of a Human-Interactive System: Insights into the Integration of Formal Methods and Human Factors Engineering

    NASA Technical Reports Server (NTRS)

    Bolton, Matthew L.; Bass, Ellen J.

    2009-01-01

    Both the human factors engineering (HFE) and formal methods communities are concerned with finding and eliminating problems with safety-critical systems. This work discusses a modeling effort that leveraged methods from both fields to use model checking with HFE practices to perform formal verification of a human-interactive system. Despite the use of a seemingly simple target system, a patient controlled analgesia pump, the initial model proved to be difficult for the model checker to verify in a reasonable amount of time. This resulted in a number of model revisions that affected the HFE architectural, representativeness, and understandability goals of the effort. If formal methods are to meet the needs of the HFE community, additional modeling tools and technological developments are necessary.

  14. Choosing the Right Systems Integration

    NASA Astrophysics Data System (ADS)

    Péči, Matúš; Važan, Pavel

    2014-12-01

    The paper examines systems integration and its main levels at higher levels of control. At present, the systems integration is one of the main aspects participating in the consolidation processes and financial flows of a company. Systems Integration is a complicated emotionconsuming process and it is often a problem to choose the right approach and level of integration. The research focused on four levels of integration, while each of them is characterized by specific conditions. At each level, there is a summary of recommendations and practical experience. The paper also discusses systems integration between the information and MES levels. The main part includes user-level integration where we describe an example of such integration. Finally, we list recommendations and also possible predictions of the systems integration as one of the important factors in the future.

  15. Man-systems integration and the man-machine interface

    NASA Technical Reports Server (NTRS)

    Hale, Joseph P.

    1990-01-01

    Viewgraphs on man-systems integration and the man-machine interface are presented. Man-systems integration applies the systems' approach to the integration of the user and the machine to form an effective, symbiotic Man-Machine System (MMS). A MMS is a combination of one or more human beings and one or more physical components that are integrated through the common purpose of achieving some objective. The human operator interacts with the system through the Man-Machine Interface (MMI).

  16. Derivation, Expansion, and Motor Neuron Differentiation of Human-Induced Pluripotent Stem Cells with Non-Integrating Episomal Vectors and a Defined Xenogeneic-free Culture System.

    PubMed

    Hu, Wentao; He, Yongpei; Xiong, Yongjie; Lu, Hong; Chen, Hong; Hou, Limin; Qiu, Zhandong; Fang, Yu; Zhang, Suming

    2016-04-01

    Induced pluripotent stem cells (iPSCs) generated from patient-derived somatic cells provides the opportunity for model development in order to study patient-specific disease states with the potential for drug discovery. However, use of lentivirus and exposure of iPSCs to animal-derived products limit their therapeutic utility and affect lineage differentiation and subsequent downstream functionality of iPSC derivatives. Within the context of this study, we describe a simple and practical protocol enabling the efficient reprogramming of terminally differentiated adult fibroblasts into integration-free human iPSCs (hiPSCs) using a combination of episomal plasmids with small molecules (SMs). Using this approach, there was a 10-fold increase in reprogramming efficiency over single plasmid vector-based methods. We obtained approximately 100 iPSCs colonies from 1 × 10(5) human adult dermal fibroblasts (HADFs) and achieved approximately 0.1% reprogramming efficiencies. Concurrently, we developed a highly conducive culture system using xeno-free media and human vitronectin. The resulting hiPSCs were free of DNA integration and had completely lost episomal vectors, maintained long-term self-renewal, featured a normal karyotype, expressed pluripotent stem cell markers, and possessed the capability of differentiating into components of all three germ layers in vivo. Finally, we demonstrate that the integration-free hiPSCs could be differentiated into motor neurons under xeno-free culture conditions. This induction method will promote the derivation of patient-specific integration-free and xeno-free iPSCs and improve the strategy for motor neuron derivation. Our approach provides a useful tool for human disease models, drug screen, and clinical applications. PMID:25663198

  17. Sustainability. Systems integration for global sustainability.

    PubMed

    Liu, Jianguo; Mooney, Harold; Hull, Vanessa; Davis, Steven J; Gaskell, Joanne; Hertel, Thomas; Lubchenco, Jane; Seto, Karen C; Gleick, Peter; Kremen, Claire; Li, Shuxin

    2015-02-27

    Global sustainability challenges, from maintaining biodiversity to providing clean air and water, are closely interconnected yet often separately studied and managed. Systems integration—holistic approaches to integrating various components of coupled human and natural systems—is critical to understand socioeconomic and environmental interconnections and to create sustainability solutions. Recent advances include the development and quantification of integrated frameworks that incorporate ecosystem services, environmental footprints, planetary boundaries, human-nature nexuses, and telecoupling. Although systems integration has led to fundamental discoveries and practical applications, further efforts are needed to incorporate more human and natural components simultaneously, quantify spillover systems and feedbacks, integrate multiple spatial and temporal scales, develop new tools, and translate findings into policy and practice. Such efforts can help address important knowledge gaps, link seemingly unconnected challenges, and inform policy and management decisions. PMID:25722418

  18. Integrated fluorescence analysis system

    DOEpatents

    Buican, Tudor N.; Yoshida, Thomas M.

    1992-01-01

    An integrated fluorescence analysis system enables a component part of a sample to be virtually sorted within a sample volume after a spectrum of the component part has been identified from a fluorescence spectrum of the entire sample in a flow cytometer. Birefringent optics enables the entire spectrum to be resolved into a set of numbers representing the intensity of spectral components of the spectrum. One or more spectral components are selected to program a scanning laser microscope, preferably a confocal microscope, whereby the spectrum from individual pixels or voxels in the sample can be compared. Individual pixels or voxels containing the selected spectral components are identified and an image may be formed to show the morphology of the sample with respect to only those components having the selected spectral components. There is no need for any physical sorting of the sample components to obtain the morphological information.

  19. NASA Human Integration Design Handbook (HIDH): Revitalization of Space-Related Human Factors, Environmental, and Habitability Data and Design Guidance

    NASA Technical Reports Server (NTRS)

    Stroud, Kenneth; Pickett, Lynn; Tillman, Barry

    2008-01-01

    This poster presentation reviews the Human Integration Design Handbook (HIDH). It provides guidance and data to aid vehicle / habitat designers in human-system integration It also aids requirements writers in development of human-system integration requirements from SFHSS Standards

  20. Advanced Integrated Traction System

    SciTech Connect

    Greg Smith; Charles Gough

    2011-08-31

    The United States Department of Energy elaborates the compelling need for a commercialized competitively priced electric traction drive system to proliferate the acceptance of HEVs, PHEVs, and FCVs in the market. The desired end result is a technically and commercially verified integrated ETS (Electric Traction System) product design that can be manufactured and distributed through a broad network of competitive suppliers to all auto manufacturers. The objectives of this FCVT program are to develop advanced technologies for an integrated ETS capable of 55kW peak power for 18 seconds and 30kW of continuous power. Additionally, to accommodate a variety of automotive platforms the ETS design should be scalable to 120kW peak power for 18 seconds and 65kW of continuous power. The ETS (exclusive of the DC/DC Converter) is to cost no more than $660 (55kW at $12/kW) to produce in quantities of 100,000 units per year, should have a total weight less than 46kg, and have a volume less than 16 liters. The cost target for the optional Bi-Directional DC/DC Converter is $375. The goal is to achieve these targets with the use of engine coolant at a nominal temperature of 105C. The system efficiency should exceed 90% at 20% of rated torque over 10% to 100% of maximum speed. The nominal operating system voltage is to be 325V, with consideration for higher voltages. This project investigated a wide range of technologies, including ETS topologies, components, and interconnects. Each technology and its validity for automotive use were verified and then these technologies were integrated into a high temperature ETS design that would support a wide variety of applications (fuel cell, hybrids, electrics, and plug-ins). This ETS met all the DOE 2010 objectives of cost, weight, volume and efficiency, and the specific power and power density 2015 objectives. Additionally a bi-directional converter was developed that provides charging and electric power take-off which is the first step

  1. Voice integrated systems

    NASA Technical Reports Server (NTRS)

    Curran, P. Mike

    1977-01-01

    The program at Naval Air Development Center was initiated to determine the desirability of interactive voice systems for use in airborne weapon systems crew stations. A voice recognition and synthesis system (VRAS) was developed and incorporated into a human centrifuge. The speech recognition aspect of VRAS was developed using a voice command system (VCS) developed by Scope Electronics. The speech synthesis capability was supplied by a Votrax, VS-5, speech synthesis unit built by Vocal Interface. The effects of simulated flight on automatic speech recognition were determined by repeated trials in the VRAS-equipped centrifuge. The relationship of vibration, G, O2 mask, mission duration, and cockpit temperature and voice quality was determined. The results showed that: (1) voice quality degrades after 0.5 hours with an O2 mask; (2) voice quality degrades under high vibration; and (3) voice quality degrades under high levels of G. The voice quality studies are summarized. These results were obtained with a baseline of 80 percent recognition accuracy with VCS.

  2. Human Resource Accounting System

    ERIC Educational Resources Information Center

    Cerullo, Michael J.

    1974-01-01

    Main objectives of human resource accounting systems are to satisfy the informational demands made by investors and by operating managers. The paper's main concern is with the internal uses of a human asset system. (Author)

  3. Symmetry and quaternionic integrable systems

    NASA Astrophysics Data System (ADS)

    Gaeta, G.; Rodríguez, M. A.

    2015-01-01

    Given a hyperkahler manifold M, the hyperkahler structure defines a triple of symplectic structures on M; with these, a triple of Hamiltonians defines a so-called hyperHamiltonian dynamical system on M. These systems are integrable when can be mapped to a system of quaternionic oscillators. We discuss the symmetry of integrable hyperHamiltonian systems, i.e. quaternionic oscillators, and conversely how these symmetries characterize, at least in the Euclidean case, integrable hyperHamiltonian systems.

  4. Reducing the Risk of Human Space Missions with INTEGRITY

    NASA Technical Reports Server (NTRS)

    Jones, Harry W.; Dillon-Merill, Robin L.; Tri, Terry O.; Henninger, Donald L.

    2003-01-01

    The INTEGRITY Program will design and operate a test bed facility to help prepare for future beyond-LEO missions. The purpose of INTEGRITY is to enable future missions by developing, testing, and demonstrating advanced human space systems. INTEGRITY will also implement and validate advanced management techniques including risk analysis and mitigation. One important way INTEGRITY will help enable future missions is by reducing their risk. A risk analysis of human space missions is important in defining the steps that INTEGRITY should take to mitigate risk. This paper describes how a Probabilistic Risk Assessment (PRA) of human space missions will help support the planning and development of INTEGRITY to maximize its benefits to future missions. PRA is a systematic methodology to decompose the system into subsystems and components, to quantify the failure risk as a function of the design elements and their corresponding probability of failure. PRA provides a quantitative estimate of the probability of failure of the system, including an assessment and display of the degree of uncertainty surrounding the probability. PRA provides a basis for understanding the impacts of decisions that affect safety, reliability, performance, and cost. Risks with both high probability and high impact are identified as top priority. The PRA of human missions beyond Earth orbit will help indicate how the risk of future human space missions can be reduced by integrating and testing systems in INTEGRITY.

  5. Integrative radiation systems biology.

    PubMed

    Unger, Kristian

    2014-01-01

    Maximisation of the ratio of normal tissue preservation and tumour cell reduction is the main concept of radiotherapy alone or combined with chemo-, immuno- or biologically targeted therapy. The foremost parameter influencing this ratio is radiation sensitivity and its modulation towards a more efficient killing of tumour cells and a better preservation of normal tissue at the same time is the overall aim of modern therapy schemas. Nevertheless, this requires a deep understanding of the molecular mechanisms of radiation sensitivity in order to identify its key players as potential therapeutic targets. Moreover, the success of conventional approaches that tried to statistically associate altered radiation sensitivity with any molecular phenotype such as gene expression proofed to be somewhat limited since the number of clinically used targets is rather sparse. However, currently a paradigm shift is taking place from pure frequentistic association analysis to the rather holistic systems biology approach that seeks to mathematically model the system to be investigated and to allow the prediction of an altered phenotype as the function of one single or a signature of biomarkers. Integrative systems biology also considers the data from different molecular levels such as the genome, transcriptome or proteome in order to partially or fully comprehend the causal chain of molecular mechanisms. An example for the application of this concept currently carried out at the Clinical Cooperation Group "Personalized Radiotherapy in Head and Neck Cancer" of the Helmholtz-Zentrum München and the LMU Munich is described. This review article strives for providing a compact overview on the state of the art of systems biology, its actual challenges, potential applications, chances and limitations in radiation oncology research working towards improved personalised therapy concepts using this relatively new methodology. PMID:24411063

  6. Arcjet system integration development

    NASA Technical Reports Server (NTRS)

    Zafran, Sidney

    1994-01-01

    Compatibility between an arcjet propulsion system and a communications satellite was verified by testing a Government-furnished, 1.4 kW hydrazine arcjet system with the FLTSATCOM qualification model satellite in a 9.1-meter (30-foot) diameter thermal-vacuum test chamber. Background pressure was maintained at 10(exp -5) torr during arcjet operation by cryopumping the thruster exhaust with an array of 5 K liquid helium cooled panels. Power for the arcjet system was obtained from the FLTSATCOM battery simulator. Spacecraft telemetry was monitored during each thruster firing period. No changes in telemetry data attributable to arcjet operation were detected in any of the tests. Electromagnetic compatibility data obtained included radiated emission measurements, conducted emission measurements, and cable coupling measurements. Significant noise was observed at lower frequencies. Above 500 MHz, radiated emissions were generally within limits, indicating that communication links at S-band and higher frequencies will not be affected. Other test data taken with a diagnostic array of calorimeters, radiometers, witness plates, and a residual gas analyzer evidenced compatible operation, and added to the data base for arcjet system integration. Two test series were conducted. The first series only included the arcjet and diagnostic array operating at approximately 0.1 torr background pressure. The second series added the qualification model spacecraft, a solar panel, and the helium cryopanels. Tests were conducted at 0.1 torr and 10(exp-5) torr. The arcjet thruster was canted 20 degrees relative to the solar panel axis, typical of the configuration used for stationkeeping thrusters on geosynchronous communications satellites.

  7. Arcjet system integration development

    NASA Astrophysics Data System (ADS)

    Zafran, Sidney

    1994-03-01

    Compatibility between an arcjet propulsion system and a communications satellite was verified by testing a Government-furnished, 1.4 kW hydrazine arcjet system with the FLTSATCOM qualification model satellite in a 9.1-meter (30-foot) diameter thermal-vacuum test chamber. Background pressure was maintained at 10(exp -5) torr during arcjet operation by cryopumping the thruster exhaust with an array of 5 K liquid helium cooled panels. Power for the arcjet system was obtained from the FLTSATCOM battery simulator. Spacecraft telemetry was monitored during each thruster firing period. No changes in telemetry data attributable to arcjet operation were detected in any of the tests. Electromagnetic compatibility data obtained included radiated emission measurements, conducted emission measurements, and cable coupling measurements. Significant noise was observed at lower frequencies. Above 500 MHz, radiated emissions were generally within limits, indicating that communication links at S-band and higher frequencies will not be affected. Other test data taken with a diagnostic array of calorimeters, radiometers, witness plates, and a residual gas analyzer evidenced compatible operation, and added to the data base for arcjet system integration. Two test series were conducted. The first series only included the arcjet and diagnostic array operating at approximately 0.1 torr background pressure. The second series added the qualification model spacecraft, a solar panel, and the helium cryopanels. Tests were conducted at 0.1 torr and 10(exp-5) torr. The arcjet thruster was canted 20 degrees relative to the solar panel axis, typical of the configuration used for stationkeeping thrusters on geosynchronous communications satellites.

  8. Integrated Management Tracking System

    2000-03-30

    The Integrated Management Tracking System (IMTS) is a "Web Enabled" Client/Server Business application that provides for the Identification and Resolution of commitments, situations, events and problems. The IMTS engine is written with Microsoft Active Server Pages (ASP) for IIS4. The system provides for reporting, entering, editing, closing and administration over a Intranet, Extranet or Internet. This Application facilitates: Electronic assignment, acceptance and tracking to completion. Email notifications of assigned action. Establishment of Due Dates. Electronicmore » search and retrieval based on keywords in combination with user specified database parameters (Document Type, Date Ranges, etc.). Coded for Trending and Reporting. User selected reports. Various levels of access for reports and administration. The "Server" side of this application consists of a Microsoft Access database running on a NT Server with Internet Information Server (IIS). As the "Client" side of the application runs on any Web browser, this solution is a cost effective, user friendly application that lends itself to organizations not physically colocated in one location providing information immediately available to everyone at once.« less

  9. Integrated Management Tracking System

    SciTech Connect

    Garrett, Terrance

    2000-03-30

    The Integrated Management Tracking System (IMTS) is a "Web Enabled" Client/Server Business application that provides for the Identification and Resolution of commitments, situations, events and problems. The IMTS engine is written with Microsoft Active Server Pages (ASP) for IIS4. The system provides for reporting, entering, editing, closing and administration over a Intranet, Extranet or Internet. This Application facilitates: Electronic assignment, acceptance and tracking to completion. Email notifications of assigned action. Establishment of Due Dates. Electronic search and retrieval based on keywords in combination with user specified database parameters (Document Type, Date Ranges, etc.). Coded for Trending and Reporting. User selected reports. Various levels of access for reports and administration. The "Server" side of this application consists of a Microsoft Access database running on a NT Server with Internet Information Server (IIS). As the "Client" side of the application runs on any Web browser, this solution is a cost effective, user friendly application that lends itself to organizations not physically colocated in one location providing information immediately available to everyone at once.

  10. Human factor integration into the development of a realistic tree-rendering system based on lidar remote sensing

    NASA Astrophysics Data System (ADS)

    Fujisaki, Ikuko; Evans, David L.; Moorhead, Robert J.; Mohammadi-Aragh, Mahnas Jean; Irby, Derek W.; Roberts, Scott D.

    2004-05-01

    This paper introduces application of the Cave Automatic Virtual Environment (CAVE) to forest visualization and user studies which were designed to gain insight into human factors for system development. This interdisciplinary research project was undertaken by the Visualization, Analysis, and Imaging Laboratory and the Department of Forestry at Mississippi State University (MSU). The purpose was to create a forest management tool for remote examination of stands in a stereoscopic environment which allows users to observe and interact with realistic virtual stands. The datasets used in this study include measurements such as total height, Diameter at the Breast Height (DBH), and crown radii. The datasets were directly and indirectly generated from Light Detection and Ranging (LiDAR) data. The datasets from immature (eight-years-old) high density and mature (40-years-old) low density loblolly pine (Pinus taeda) stands were used to generate three types of tree models. These three models represent trees in different graphic-complexities and thus interactivity. In general, higher fidelity is preferred in visualization. However, there is a trade-off between graphic details and interaction speed. To determine an optimal model, a user study was designed to examine the influence photo-reality and interactivity have on the viewer's perception. Human subjects recruited from MSU's Department of Forestry will explore virtual stands rendered with one of the tree models in the CAVE and estimate forest parameters.

  11. Integrated clinical information system.

    PubMed

    Brousseau, G

    1995-01-01

    SIDOCI (Système Informatisé de DOnnées Cliniques Intégrées) is a Canadian joint venture introducing newly-operating paradigms into hospitals. The main goal of SIDOCI is to maintain the quality of care in todayUs tightening economy. SIDOCI is a fully integrated paperless patient-care system which automates and links all information about a patient. Data is available on-line and instantaneously to doctors, nurses, and support staff in the format that best suits their specific requirements. SIDOCI provides a factual and chronological summary of the patient's progress by drawing together clinical information provided by all professionals working with the patient, regardless of their discipline, level of experience, or physical location. It also allows for direct entry of the patient's information at the bedside. Laboratory results, progress notes, patient history and graphs are available instantaneously on screen, eliminating the need for physical file transfers. The system, incorporating a sophisticated clinical information database, an intuitive graphical user interface, and customized screens for each medical discipline, guides the user through standard procedures. Unlike most information systems created for the health care industry, SIDOCI is longitudinal, covering all aspects of the health care process through its link to various vertical systems already in place. A multidisciplinary team has created a clinical dictionary that provides the user with most of the information she would normally use: symptoms, signs, diagnoses, allergies, medications, interventions, etc. This information is structured and displayed in such a manner that health care professionals can document the clinical situation at the touch of a finger. The data is then encoded into the patient's file. Once encoded, the structured data is accessible for research, statistics, education, and quality assurance. This dictionary complies with national and international nomenclatures. It also

  12. Buried waste integrated demonstration human engineered control station. Final report

    SciTech Connect

    Not Available

    1994-09-01

    This document describes the Human Engineered Control Station (HECS) project activities including the conceptual designs. The purpose of the HECS is to enhance the effectiveness and efficiency of remote retrieval by providing an integrated remote control station. The HECS integrates human capabilities, limitations, and expectations into the design to reduce the potential for human error, provides an easy system to learn and operate, provides an increased productivity, and reduces the ultimate investment in training. The overall HECS consists of the technology interface stations, supporting engineering aids, platform (trailer), communications network (broadband system), and collision avoidance system.

  13. Functional Micro-Dispensers based on Micro-Electro-Mechanical-Systems (MEMS) integrated with fabrics as functional materials to protect humans from mosquito feeding.

    PubMed

    Bernier, Ulrich R; Gurman, Pablo; Clark, Gary G; Elman, Noel

    2015-12-28

    Functional Micro-Dispensers (FMDs) based on Micro-Electro-Mechanical-Systems (MEMS) were designed to deliver spatial repellents that reduce the ability of mosquitoes to feed on humans. FMDs were integrated with fabrics as functional materials for protection against mosquito bites. The use of MEMS devices provides an unprecedented control over the release kinetics by means of integration with electronics for selective and timely activation of each device to perform controlled release of pesticides in air. In addition, because MEMS manufacturing techniques evolved from the microelectronic industry, FMDs can be mass produced at very low cost. Trials using FMDs that contained transfluthrin improved protection against mosquito feeding in human subjects above that of permethrin-treated uniform fabric worn on the arm of the volunteer. The overall reduction in feeding was approximately 90% compared to the untreated fabric control, and about 50% reduction compared to the permethrin-treated fabric control. The devices were efficacious over course of 32 days. FMDs have the potential for a simple and cost-effective implementation for mass adoption as wearable devices integrated in fabrics as active functional materials. PMID:26415856

  14. Integrated system checkout report

    SciTech Connect

    Not Available

    1991-08-14

    The planning and preparation phase of the Integrated Systems Checkout Program (ISCP) was conducted from October 1989 to July 1991. A copy of the ISCP, DOE-WIPP 90--002, is included in this report as an appendix. The final phase of the Checkout was conducted from July 10, 1991, to July 23, 1991. This phase exercised all the procedures and equipment required to receive, emplace, and retrieve contact handled transuranium (CH TRU) waste filled dry bins. In addition, abnormal events were introduced to simulate various equipment failures, loose surface radioactive contamination events, and personnel injury. This report provides a detailed summary of each days activities during this period. Qualification of personnel to safely conduct the tasks identified in the procedures and the abnormal events were verified by observers familiar with the Bin-Scale CH TRU Waste Test requirements. These observers were members of the staffs of Westinghouse WID Engineering, QA, Training, Health Physics, Safety, and SNL. Observers representing a number of DOE departments, the state of new Mexico, and the Defense Nuclear Facilities Safety Board observed those Checkout activities conducted during the period from July 17, 1991, to July 23, 1991. Observer comments described in this report are those obtained from the staff member observers. 1 figs., 1 tab.

  15. Integrating Workforce Planning, Human Resources, and Service Planning.

    ERIC Educational Resources Information Center

    O'Brien-Pallas, Linda; Birch, Stephen; Baumann, Andrea; Murphy, Gail Tomblin

    The feasibility of integrated health human resources planning (IHHRP) was examined. The analysis focused on the following topics: ways of integrating labor market indicators into service planning; whether planning is sufficiently responsive and flexible to retain relevance and validity in rapidly changing health systems; different models and…

  16. INTERCONNECTIONS BETWEEN HUMAN HEALTH AND ECOLOGICAL INTEGRITY

    EPA Science Inventory

    Interconnections between Human Health and Ecological Integrity emanates from a June 2000 Pellston Workshop in Snowbird, Utah, USA. Jointly sponsored by the Society of Environmental Toxicology and Chemistry (SETAC) and the Society of Toxicology (SOT), the workshop was motivated by...

  17. Advanced control room design review guidelines: Integration of the NUREG-0700 guidelines and development of new human-system interface guidelines

    SciTech Connect

    Carter, R.J.

    1997-07-01

    This report documents the work conducted in four tasks of the Nuclear Regulatory Commission (NRC) project entitled Review Criteria for Human Factors Aspects of Advanced Controls and Instrumentation. The purpose of the first task was to integrate the applicable sections of NUREG-0700 into the advanced control room design review (ACRDR) guidelines to ensure that all applicable guidelines are together in one document and conveniently accessible to users. The primary objective of the second task was to formulate a strategy for the development of new ACRDR guidelines that have not otherwise been identified. The main focus of the third task was to modify the individual ACRDR guidelines generated to date to ensure that they are suitable for the intended nuclear power plant (NPP) control station system application. The goal of the fourth task was to develop human factors guidelines for two human-system interface categories that are missing from the current ACRDR guidelines document. During the first task those areas in NUREG-0700 that are not addressed by the ACRDR guidelines document were identified, the areas were subsequently reviewed against six recent industry human factors engineering review guidelines, and the NUREG-0700 guidelines were updated as necessary. In the second task 13 general categories of human-system interface guidelines that are either missing from or not adequately addressed by the ACRDR document were discovered. An approach was derived for the development of new ACRDR guidelines, a preliminary assessment of the available sources that may be useful in the creation of new guidelines and their applicability to the identified human-system interface categories was performed, and an estimate was made of the amount of time and level of effort required to complete the development of needed new ACRDR guidelines. During the third task those NPP control station systems to which the NUREG-0700 and ACRDR guidelines apply were identified, matrices of such

  18. Noncommutative integrable systems and quasideterminants

    SciTech Connect

    Hamanaka, Masashi

    2010-03-08

    We discuss extension of soliton theories and integrable systems into noncommutative spaces. In the framework of noncommutative integrable hierarchy, we give infinite conserved quantities and exact soliton solutions for many noncommutative integrable equations, which are represented in terms of Strachan's products and quasi-determinants, respectively. We also present a relation to an noncommutative anti-self-dual Yang-Mills equation, and make comments on how 'integrability' should be considered in noncommutative spaces.

  19. The Human Subsystem - Definition and Integration

    NASA Technical Reports Server (NTRS)

    vonBengston, Kristian; Twyford, Evan

    2007-01-01

    This paper will discuss the use of the human subsystem in development phases of human space flight. Any space mission has clearly defined subsystems, managed by experts attached to these. Clearly defined subsystems and correct use provide easier and more efficient development for each independent subsystem and for the relation between these subsystems. Furthermore, this paper will argue that a defined subsystem related to humans in space has not always been clearly present, and that correct implementation is perhaps missing, based on experience and survey data. Finally, the authors will discuss why the human subsystem has not been fully integrated, why it must be a mandatory part of the programming, a re-definition of the human subsystem, and suggestions of methods to improve the integration of human factors in the development.

  20. Central Fan Integrated Ventilation Systems

    SciTech Connect

    2009-05-12

    This information sheet describes one example of a ventilation system design, a central fan integrated supply (CFIS) system, a mechanical ventilation and pollutant source control to ensure that there is reasonable indoor air quality inside the house.

  1. Energy Systems Integration Facility Overview

    ScienceCinema

    Arvizu, Dan; Chistensen, Dana; Hannegan, Bryan; Garret, Bobi; Kroposki, Ben; Symko-Davies, Martha; Post, David; Hammond, Steve; Kutscher, Chuck; Wipke, Keith

    2014-06-10

    The U.S. Department of Energy's Energy Systems Integration Facility (ESIF) is located at the National Renewable Energy Laboratory is the right tool, at the right time... a first-of-its-kind facility that addresses the challenges of large-scale integration of clean energy technologies into the energy systems that power the nation.

  2. Energy Systems Integration Facility Overview

    SciTech Connect

    Arvizu, Dan; Chistensen, Dana; Hannegan, Bryan; Garret, Bobi; Kroposki, Ben; Symko-Davies, Martha; Post, David; Hammond, Steve; Kutscher, Chuck; Wipke, Keith

    2014-02-28

    The U.S. Department of Energy's Energy Systems Integration Facility (ESIF) is located at the National Renewable Energy Laboratory is the right tool, at the right time... a first-of-its-kind facility that addresses the challenges of large-scale integration of clean energy technologies into the energy systems that power the nation.

  3. System integration test plan for HANDI 2000 business management system

    SciTech Connect

    Wilson, D.

    1998-08-24

    This document presents the system integration test plan for the Commercial-Off-The-Shelf, PassPort and PeopleSoft software, and custom software created to work with the COTS products. The PP software is an integrated application for AP, Contract Management, Inventory Management, Purchasing and Material Safety Data Sheet. The PS software is an integrated application for Project Costing, General Ledger, Human Resources/Training, Payroll, and Base Benefits.

  4. Systems Engineering and Integration for Technology Programs

    NASA Technical Reports Server (NTRS)

    Kennedy, Kruss J.

    2006-01-01

    The Architecture, Habitability & Integration group (AH&I) is a system engineering and integration test team within the NASA Crew and Thermal Systems Division (CTSD) at Johnson Space Center. AH&I identifies and resolves system-level integration issues within the research and technology development community. The timely resolution of these integration issues is fundamental to the development of human system requirements and exploration capability. The integration of the many individual components necessary to construct an artificial environment is difficult. The necessary interactions between individual components and systems must be approached in a piece-wise fashion to achieve repeatable results. A formal systems engineering (SE) approach to define, develop, and integrate quality systems within the life support community has been developed. This approach will allow a Research & Technology Program to systematically approach the development, management, and quality of technology deliverables to the various exploration missions. A tiered system engineering structure has been proposed to implement best systems engineering practices across all development levels from basic research to working assemblies. These practices will be implemented through a management plan across all applicable programs, projects, elements and teams. While many of the engineering practices are common to other industries, the implementation is specific to technology development. An accounting of the systems engineering management philosophy will be discussed and the associated programmatic processes will be presented.

  5. Integrated Learning Management Systems

    ERIC Educational Resources Information Center

    Clark, Sharon; Cossarin, Mary; Doxsee, Harry; Schwartz, Linda

    2004-01-01

    Four integrated learning management packages were reviewed: "CentraOne", "IntraLearn", "Lyceum", and "Silicon Chalk". These products provide different combinations of synchronous and asynchronous tools. The current report examines the products in relation to their specific value for distance educators and students.

  6. Unmanned Aircraft Systems (UAS) Integration in the National Airspace System (NAS) Project Subcommittee Final

    NASA Technical Reports Server (NTRS)

    Johnson, Chuck; Griner, James H.; Hayhurst, Kelly J.; Shively, Robert J.; Consiglio, Maria; Muller, Eric; Murphy, James; Kim, Sam

    2012-01-01

    UAS Integration in the NAS Project overview with details from each of the subprojects. Subprojects include: Communications, Certification, Integrated Test and Evaluation, Human Systems Integration, and Separation Assurance/Sense and Avoid Interoperability.

  7. Integrative analysis of 111 reference human epigenomes

    PubMed Central

    Kundaje, Anshul; Meuleman, Wouter; Ernst, Jason; Bilenky, Misha; Yen, Angela; Kheradpour, Pouya; Zhang, Zhizhuo; Heravi-Moussavi, Alireza; Liu, Yaping; Amin, Viren; Ziller, Michael J; Whitaker, John W; Schultz, Matthew D; Sandstrom, Richard S; Eaton, Matthew L; Wu, Yi-Chieh; Wang, Jianrong; Ward, Lucas D; Sarkar, Abhishek; Quon, Gerald; Pfenning, Andreas; Wang, Xinchen; Claussnitzer, Melina; Coarfa, Cristian; Harris, R Alan; Shoresh, Noam; Epstein, Charles B; Gjoneska, Elizabeta; Leung, Danny; Xie, Wei; Hawkins, R David; Lister, Ryan; Hong, Chibo; Gascard, Philippe; Mungall, Andrew J; Moore, Richard; Chuah, Eric; Tam, Angela; Canfield, Theresa K; Hansen, R Scott; Kaul, Rajinder; Sabo, Peter J; Bansal, Mukul S; Carles, Annaick; Dixon, Jesse R; Farh, Kai-How; Feizi, Soheil; Karlic, Rosa; Kim, Ah-Ram; Kulkarni, Ashwinikumar; Li, Daofeng; Lowdon, Rebecca; Mercer, Tim R; Neph, Shane J; Onuchic, Vitor; Polak, Paz; Rajagopal, Nisha; Ray, Pradipta; Sallari, Richard C; Siebenthall, Kyle T; Sinnott-Armstrong, Nicholas; Stevens, Michael; Thurman, Robert E; Wu, Jie; Zhang, Bo; Zhou, Xin; Beaudet, Arthur E; Boyer, Laurie A; De Jager, Philip; Farnham, Peggy J; Fisher, Susan J; Haussler, David; Jones, Steven; Li, Wei; Marra, Marco; McManus, Michael T; Sunyaev, Shamil; Thomson, James A; Tlsty, Thea D; Tsai, Li-Huei; Wang, Wei; Waterland, Robert A; Zhang, Michael; Chadwick, Lisa H; Bernstein, Bradley E; Costello, Joseph F; Ecker, Joseph R; Hirst, Martin; Meissner, Alexander; Milosavljevic, Aleksandar; Ren, Bing; Stamatoyannopoulos, John A; Wang, Ting; Kellis, Manolis

    2015-01-01

    The reference human genome sequence set the stage for studies of genetic variation and its association with human disease, but a similar reference has lacked for epigenomic studies. To address this need, the NIH Roadmap Epigenomics Consortium generated the largest collection to-date of human epigenomes for primary cells and tissues. Here, we describe the integrative analysis of 111 reference human epigenomes generated as part of the program, profiled for histone modification patterns, DNA accessibility, DNA methylation, and RNA expression. We establish global maps of regulatory elements, define regulatory modules of coordinated activity, and their likely activators and repressors. We show that disease and trait-associated genetic variants are enriched in tissue-specific epigenomic marks, revealing biologically-relevant cell types for diverse human traits, and providing a resource for interpreting the molecular basis of human disease. Our results demonstrate the central role of epigenomic information for understanding gene regulation, cellular differentiation, and human disease. PMID:25693563

  8. Integrative analysis of 111 reference human epigenomes.

    PubMed

    Kundaje, Anshul; Meuleman, Wouter; Ernst, Jason; Bilenky, Misha; Yen, Angela; Heravi-Moussavi, Alireza; Kheradpour, Pouya; Zhang, Zhizhuo; Wang, Jianrong; Ziller, Michael J; Amin, Viren; Whitaker, John W; Schultz, Matthew D; Ward, Lucas D; Sarkar, Abhishek; Quon, Gerald; Sandstrom, Richard S; Eaton, Matthew L; Wu, Yi-Chieh; Pfenning, Andreas R; Wang, Xinchen; Claussnitzer, Melina; Liu, Yaping; Coarfa, Cristian; Harris, R Alan; Shoresh, Noam; Epstein, Charles B; Gjoneska, Elizabeta; Leung, Danny; Xie, Wei; Hawkins, R David; Lister, Ryan; Hong, Chibo; Gascard, Philippe; Mungall, Andrew J; Moore, Richard; Chuah, Eric; Tam, Angela; Canfield, Theresa K; Hansen, R Scott; Kaul, Rajinder; Sabo, Peter J; Bansal, Mukul S; Carles, Annaick; Dixon, Jesse R; Farh, Kai-How; Feizi, Soheil; Karlic, Rosa; Kim, Ah-Ram; Kulkarni, Ashwinikumar; Li, Daofeng; Lowdon, Rebecca; Elliott, GiNell; Mercer, Tim R; Neph, Shane J; Onuchic, Vitor; Polak, Paz; Rajagopal, Nisha; Ray, Pradipta; Sallari, Richard C; Siebenthall, Kyle T; Sinnott-Armstrong, Nicholas A; Stevens, Michael; Thurman, Robert E; Wu, Jie; Zhang, Bo; Zhou, Xin; Beaudet, Arthur E; Boyer, Laurie A; De Jager, Philip L; Farnham, Peggy J; Fisher, Susan J; Haussler, David; Jones, Steven J M; Li, Wei; Marra, Marco A; McManus, Michael T; Sunyaev, Shamil; Thomson, James A; Tlsty, Thea D; Tsai, Li-Huei; Wang, Wei; Waterland, Robert A; Zhang, Michael Q; Chadwick, Lisa H; Bernstein, Bradley E; Costello, Joseph F; Ecker, Joseph R; Hirst, Martin; Meissner, Alexander; Milosavljevic, Aleksandar; Ren, Bing; Stamatoyannopoulos, John A; Wang, Ting; Kellis, Manolis

    2015-02-19

    The reference human genome sequence set the stage for studies of genetic variation and its association with human disease, but epigenomic studies lack a similar reference. To address this need, the NIH Roadmap Epigenomics Consortium generated the largest collection so far of human epigenomes for primary cells and tissues. Here we describe the integrative analysis of 111 reference human epigenomes generated as part of the programme, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression. We establish global maps of regulatory elements, define regulatory modules of coordinated activity, and their likely activators and repressors. We show that disease- and trait-associated genetic variants are enriched in tissue-specific epigenomic marks, revealing biologically relevant cell types for diverse human traits, and providing a resource for interpreting the molecular basis of human disease. Our results demonstrate the central role of epigenomic information for understanding gene regulation, cellular differentiation and human disease. PMID:25693563

  9. An Integrated Modeling Platform for Human and Ecological Exposure and Risk in Multimedia Environmental Systems (HE2RMES)

    EPA Science Inventory

    When considering potentially hazardous materials in the context of initial use, reuse, recycling, or ultimate disposal in the landscape, a crux of most decision will be understanding the cumulative contaminant exposure and risk of a given material to human health and well-being. ...

  10. The Chernobyl Tissue Bank — A Repository for Biomaterial and Data Used in Integrative and Systems Biology Modeling the Human Response to Radiation

    PubMed Central

    Thomas, Geraldine; Unger, Kristian; Krznaric, Marko; Galpine, Angela; Bethel, Jackie; Tomlinson, Christopher; Woodbridge, Mark; Butcher, Sarah

    2012-01-01

    The only unequivocal radiological effect of the Chernobyl accident on human health is the increase in thyroid cancer in those exposed in childhood or early adolescence. In response to the scientific interest in studying the molecular biology of thyroid cancer post Chernobyl, the Chernobyl Tissue Bank (CTB: www.chernobyltissuebank.com) was established in 1998. Thus far it is has collected biological samples from 3,861 individuals, and provided 27 research projects with 11,254 samples. The CTB was designed from its outset as a resource to promote the integration of research and clinical data to facilitate a systems biology approach to radiation related thyroid cancer. The project has therefore developed as a multidisciplinary collaboration between clinicians, dosimetrists, molecular biologists and bioinformaticians and serves as a paradigm for tissue banking in the omics era. PMID:24704918

  11. Quantifying the environmental impact of an integrated human/industrial-natural system using life cycle assessment; a case study on a forest and wood processing chain.

    PubMed

    Schaubroeck, Thomas; Alvarenga, Rodrigo A F; Verheyen, Kris; Muys, Bart; Dewulf, Jo

    2013-01-01

    Life Cycle Assessment (LCA) is a tool to assess the environmental sustainability of a product; it quantifies the environmental impact of a product's life cycle. In conventional LCAs, the boundaries of a product's life cycle are limited to the human/industrial system, the technosphere. Ecosystems, which provide resources to and take up emissions from the technosphere, are not included in those boundaries. However, similar to the technosphere, ecosystems also have an impact on their (surrounding) environment through their resource usage (e.g., nutrients) and emissions (e.g., CH4). We therefore propose a LCA framework to assess the impact of integrated Techno-Ecological Systems (TES), comprising relevant ecosystems and the technosphere. In our framework, ecosystems are accounted for in the same manner as technosphere compartments. Also, the remediating effect of uptake of pollutants, an ecosystem service, is considered. A case study was performed on a TES of sawn timber production encompassing wood growth in an intensively managed forest ecosystem and further industrial processing. Results show that the managed forest accounted for almost all resource usage and biodiversity loss through land occupation but also for a remediating effect on human health, mostly via capture of airborne fine particles. These findings illustrate the potential relevance of including ecosystems in the product's life cycle of a LCA, though further research is needed to better quantify the environmental impact of TES. PMID:24195778

  12. Human action recognition using integrated model

    NASA Astrophysics Data System (ADS)

    Yi, Yang; Lin, Yikun

    2013-07-01

    A novel action recognition framework based on integrated model is proposed in the paper. First, the covariance descriptor is utilized to extract features from video sequences, and then each class specific codebook is constructed and appended to the global codebook. A static model applying the template matching technique and a dynamic model employing the trigram model are learned to capture complementary information in an action. And lastly, an integrated model is used to estimate the confidence of the static and dynamic models and produces a reliable result. Comparative experiments show that our presented method achieves superior results over other state-of-the-art approaches. Keywords: human action recognition, covariance descriptor, integrated model

  13. Integrated Workforce Modeling System

    NASA Technical Reports Server (NTRS)

    Moynihan, Gary P.

    2000-01-01

    There are several computer-based systems, currently in various phases of development at KSC, which encompass some component, aspect, or function of workforce modeling. These systems may offer redundant capabilities and/or incompatible interfaces. A systems approach to workforce modeling is necessary in order to identify and better address user requirements. This research has consisted of two primary tasks. Task 1 provided an assessment of existing and proposed KSC workforce modeling systems for their functionality and applicability to the workforce planning function. Task 2 resulted in the development of a proof-of-concept design for a systems approach to workforce modeling. The model incorporates critical aspects of workforce planning, including hires, attrition, and employee development.

  14. Use of a combination of methods of biological and physicochemical utilization of vegetative waste products and the human's exometabolites for creation of integrated life support systems

    NASA Astrophysics Data System (ADS)

    Zolotukhin, I. G.; Tikhomirov, A. A.; Kudenko, Y. A.; Gribovskaya, I. V.

    Possibility of inclusion into internal mass exchange the human's exometabolites and an inedible biomass of the higher plants (on the example of wheat) due to combined use of methods of "biological" and "wet" combustion were estimated in this work. Wheat was grown on soil-like substrate (SLS) which was a product of processing of wheat inedible biomass (leaves, straw, roots) with the help of Californian worms and accompanying microflora. The inedible wheat biomass was restored to SLS where it was exposed to decomposition ("biological" combustion) up to mineral compounds which were assimilated by plants. Before accession in turnover the human's exometabolites were exposed to physicochemical processing according to special technology. Processed by this way the human's exometabolites proceeded in a nutrient solution for plants. Periodically (once in 60 - 70 days) the nutrient solution was partly desalinated (up to 50 %) by the way of electrodialysis. The received salt concentrate could be used in the human's nutrition by the way of NaCl extraction and return of the left elements into turnover through the human's liquid excretions. The grain output had oscillatory character and depended, basically, from value of returned to SLS inedible biomass and speed of its decomposition. After an outcome on a stationary mode the grain shortage in comparison with the control variant did not exceed 30 %, and in some cases was comparable with the control values. The most important parameter influencing efficiency of turnover was NaCl content in the system "a plant - SLS". According to Na Cl accumulation grain and straw appeared to be conservative to which average relative NaCl concentration counting upon dry matter made up 0,02 % and 0,18 % accordingly. Active NaCl accumulation was marked in roots (from 0,18 up to 0,41 % and in SLS (from 0,13 up to 0,24 %), and by the end of experiments the growth of NaCl concentration in these system components tended to saturation. In a nutrient

  15. Integrated multiplexed capillary electrophoresis system

    SciTech Connect

    Yeung, Edward S.; Tan, Hongdong

    2002-05-14

    The present invention provides an integrated multiplexed capillary electrophoresis system for the analysis of sample analytes. The system integrates and automates multiple components, such as chromatographic columns and separation capillaries, and further provides a detector for the detection of analytes eluting from the separation capillaries. The system employs multiplexed freeze/thaw valves to manage fluid flow and sample movement. The system is computer controlled and is capable of processing samples through reaction, purification, denaturation, pre-concentration, injection, separation and detection in parallel fashion. Methods employing the system of the invention are also provided.

  16. An Integrated Systems Approach is Needed to Ensure the Sustainability of Antibiotic Effectiveness for Both Humans and Animals.

    PubMed

    So, Anthony D; Shah, Tejen A; Roach, Steven; Ling Chee, Yoke; Nachman, Keeve E

    2015-01-01

    The growing demand for animal products and the widespread use of antibiotics in bringing food animals to market have heightened concerns over cross-species transmission of drug resistance. Both the biology and emerging epidemiology strongly support the need for global coordination in stemming the generation and propagation of resistance, and the patchwork of global and country-level regulations still leaves significant gaps. More importantly, discussing such a framework opens the door to taking modular steps towards solving these challenges - for example, beginning among targeted parties rather than all countries, tying accountability to financial and technical support, or taxing antibiotic use in animals to deter low-value usage of these drugs. An international agreement would allow integrating surveillance data collection, monitoring and enforcement, research into antibiotic alternatives and more sustainable approaches to agriculture, technical assistance and capacity building, and financing under the umbrella of a One Health approach. PMID:26243242

  17. Integrated simulations of human cognition and behavior

    NASA Astrophysics Data System (ADS)

    Cassimatis, Nicholas L.

    2005-05-01

    Cognitive architectures are promising tools for creating simulations of human behavior because they were designed to model the cognitive processes that choose that behavior. However, the fact that multiple factors - e.g. physical, social, moral, political, economic - influence the actions of human beings is an obstacle to using these architectures because the various mechanisms the mind uses to consider each factor are currently best modeled using many different computational methods and no single architecture can easily implement them all. This paper presents a cognitive architecture for integrating models based on many different computational methods. It is intended to enable more realistic models and simulations of human behavior.

  18. Integrating Humanities and Educational Travel Abroad Programs.

    ERIC Educational Resources Information Center

    Cornelius, Erwin C.

    Various materials are presented to provide guidelines for integrating humanities and travel abroad programs. After noting the long tradition of educational travel and the recent emergence of travel study programs for adult learners, the study-travel program at McHenry County College, a small rural community college in Illinois, is briefly…

  19. Integrated Humanities in Florida Community Colleges.

    ERIC Educational Resources Information Center

    Brown, Dion K.

    During October and November of 1975, course outlines were solicited from the sixteen Florida community colleges offering an integrated humanities course. Ten colleges provided outlines, which were subsequently reviewed in terms of the textual materials used, the teaching approach employed, and stated objectives. The review showed that all of the…

  20. Public humanization policies: integrative literature review.

    PubMed

    Moreira, Márcia Adriana Dias Meirelles; Lustosa, Abdon Moreira; Dutra, Fernando; Barros, Eveline de Oliveira; Batista, Jaqueline Brito Vidal; Duarte, Marcella Costa Souto

    2015-10-01

    The study aimed to investigate the scientific literature on Public Humanization Policies, available in online periodicals, from 2009 to 2012, in the health field. This is an integrative literature review conducted in the Virtual Health Library databases: Latin-America and Caribbean Health Sciences (Lilacs) and the Scientific Electronic Library Online (SciELO) and Portal Capes. Data were collected in July 2013. To this end, the following Health Sciences Descriptors (DeCS) were used: "Humanization of Care," "Public Policies," "National Humanization Policy". The sample consisted of 27 articles about the investigated theme. From the publications selected for the research, three categories emerged according to their respective approaches: National Human-ization Policy: history and processes involved in its implementation; National Humanization Policy: health professionals contribution; Humanization and in the care process. The study showed that the National Humanization Policy is an important benchmark in the development of health practices. For this reason, there is a pressing multiplication of related reflections on ways to promote human-ization in health services. PMID:26465863

  1. Digital system bus integrity

    NASA Technical Reports Server (NTRS)

    Eldredge, Donald; Hitt, Ellis F.

    1987-01-01

    This report summarizes and describes the results of a study of current or emerging multiplex data buses as applicable to digital flight systems, particularly with regard to civil aircraft. Technology for pre-1995 and post-1995 timeframes has been delineated and critiqued relative to the requirements envisioned for those periods. The primary emphasis has been an assured airworthiness of the more prevalent type buses, with attention to attributes such as fault tolerance, environmental susceptibility, and problems under continuing investigation. Additionally, the capacity to certify systems relying on such buses has been addressed.

  2. Integrated Communication Systems.

    ERIC Educational Resources Information Center

    Simpson, Ward

    2003-01-01

    Describes the Internet-based information system that has provided effective communications and reporting for the upgrade to K-12 schools in Scottsdale, Arizona. The Website and software applications created valuable communications in the construction process and improved reporting on progress. (SLD)

  3. Intelligent Integrated System Health Management

    NASA Technical Reports Server (NTRS)

    Figueroa, Fernando

    2012-01-01

    Intelligent Integrated System Health Management (ISHM) is the management of data, information, and knowledge (DIaK) with the purposeful objective of determining the health of a system (Management: storage, distribution, sharing, maintenance, processing, reasoning, and presentation). Presentation discusses: (1) ISHM Capability Development. (1a) ISHM Knowledge Model. (1b) Standards for ISHM Implementation. (1c) ISHM Domain Models (ISHM-DM's). (1d) Intelligent Sensors and Components. (2) ISHM in Systems Design, Engineering, and Integration. (3) Intelligent Control for ISHM-Enabled Systems

  4. Crew system dynamics - Combining humans and automation

    NASA Technical Reports Server (NTRS)

    Connors, Mary

    1989-01-01

    Some of the human factor issues involved in effectively combining human and automated systems are examined with particular reference to spaceflights. The concepts of the crew system and crew systems dynamics are defined, and the present status of crew systems is summarized. The possibilities and potential problems aasociated with the use of automated systems are discussed, as are unique capabilities and possible errors introduced by human participants. It is emphasized that the true integration of human and automated systems must allow for the characteristics of both.

  5. Integrated agricultural energy system

    NASA Astrophysics Data System (ADS)

    Taylor, R. M.

    1985-08-01

    The purpose of this program is to show New England farmers and other New England energy users how they can use alternative energy sources to reduce their energy cost and dependency on conventional sources. The project demonstrates alternative energy technologies in solar, alcohol and methane. Dissemination is planned through tours to be conducted by the Worcester County Extension Service. Most of these goals were completed as planned. A few things have yet to be completed. The solar panels and solar hot water tanks have to be installed. The fermenter's agitating and cooling system have to be secured inside the fermenter. Once these items are complete tours will begin early in the spring.

  6. Human Factors Interface with Systems Engineering for NASA Human Spaceflights

    NASA Technical Reports Server (NTRS)

    Wong, Douglas T.

    2009-01-01

    This paper summarizes the past and present successes of the Habitability and Human Factors Branch (HHFB) at NASA Johnson Space Center s Space Life Sciences Directorate (SLSD) in including the Human-As-A-System (HAAS) model in many NASA programs and what steps to be taken to integrate the Human-Centered Design Philosophy (HCDP) into NASA s Systems Engineering (SE) process. The HAAS model stresses systems are ultimately designed for the humans; the humans should therefore be considered as a system within the systems. Therefore, the model places strong emphasis on human factors engineering. Since 1987, the HHFB has been engaging with many major NASA programs with much success. The HHFB helped create the NASA Standard 3000 (a human factors engineering practice guide) and the Human Systems Integration Requirements document. These efforts resulted in the HAAS model being included in many NASA programs. As an example, the HAAS model has been successfully introduced into the programmatic and systems engineering structures of the International Space Station Program (ISSP). Success in the ISSP caused other NASA programs to recognize the importance of the HAAS concept. Also due to this success, the HHFB helped update NASA s Systems Engineering Handbook in December 2007 to include HAAS as a recommended practice. Nonetheless, the HAAS model has yet to become an integral part of the NASA SE process. Besides continuing in integrating HAAS into current and future NASA programs, the HHFB will investigate incorporating the Human-Centered Design Philosophy (HCDP) into the NASA SE Handbook. The HCDP goes further than the HAAS model by emphasizing a holistic and iterative human-centered systems design concept.

  7. Integrated Building Management System (IBMS)

    SciTech Connect

    Anita Lewis

    2012-07-01

    This project provides a combination of software and services that more easily and cost-effectively help to achieve optimized building performance and energy efficiency. Featuring an open-platform, cloud- hosted application suite and an intuitive user experience, this solution simplifies a traditionally very complex process by collecting data from disparate building systems and creating a single, integrated view of building and system performance. The Fault Detection and Diagnostics algorithms developed within the IBMS have been designed and tested as an integrated component of the control algorithms running the equipment being monitored. The algorithms identify the normal control behaviors of the equipment without interfering with the equipment control sequences. The algorithms also work without interfering with any cooperative control sequences operating between different pieces of equipment or building systems. In this manner the FDD algorithms create an integrated building management system.

  8. NASA Human Integration Design Handbook (HIDH): Revitalization of Space-Related Human Factors, Environmental and Habitability Data

    NASA Technical Reports Server (NTRS)

    Russo, Dane; Pickett, Lynn; Tillman, Barry; Foley, Tico

    2007-01-01

    This chart illustrates the contents for NASA's Human Integration Design Handbook, which is being developed as a new reference handbook for designing systems which accomodate the capabilities and limitations of the human crew.

  9. Integrated high power VCSEL systems

    NASA Astrophysics Data System (ADS)

    Moench, Holger; Conrads, Ralf; Gronenborn, Stephan; Gu, Xi; Miller, Michael; Pekarski, Pavel; Pollmann-Retsch, Jens; Pruijmboom, Armand; Weichmann, Ulrich

    2016-03-01

    High power VCSEL systems are a novel laser source used for thermal treatment in industrial manufacturing. These systems will be applied in many applications, which have not used a laser source before. This is enabled by the unique combination of efficiency, compactness and robustness. High power VCSEL system technology encompasses elements far beyond the VCSEL chip itself: i.e. heat sinks, bonding technology and integrated optics. This paper discusses the optimization of these components and processes specifically for building high-power laser systems with VCSEL arrays. New approaches help to eliminate components and process steps and make the system more robust and easier to manufacture. New cooler concepts with integrated electrical and mechanical interfaces have been investigated and offer advantages for high power system design. The bonding process of chips on sub-mounts and coolers has been studied extensively and for a variety of solder materials. High quality of the interfaces as well as good reliability under normal operation and thermal cycling have been realized. A viable alternative to soldering is silver sintering. The very positive results which have been achieved with a variety of technologies indicate the robustness of the VCSEL chips and their suitability for high power systems. Beam shaping micro-optics can be integrated on the VCSEL chip in a wafer scale process by replication of lenses in a polymer layer. The performance of VCSEL arrays with integrated collimation lenses has been positively evaluated and the integrated chips are fully compatible with all further assembly steps. The integrated high power systems make the application even easier and more robust. New examples in laser material processing and pumping of solid state lasers are presented.

  10. Symplectic integrators for spin systems.

    PubMed

    McLachlan, Robert I; Modin, Klas; Verdier, Olivier

    2014-06-01

    We present a symplectic integrator, based on the implicit midpoint method, for classical spin systems where each spin is a unit vector in R{3}. Unlike splitting methods, it is defined for all Hamiltonians and is O(3)-equivariant, i.e., coordinate-independent. It is a rare example of a generating function for symplectic maps of a noncanonical phase space. It yields a new integrable discretization of the spinning top. PMID:25019718

  11. Risk Interfaces to Support Integrated Systems Analysis and Development

    NASA Technical Reports Server (NTRS)

    Mindock, Jennifer; Lumpkins, Sarah; Shelhamer, Mark; Anton, Wilma; Havenhill, Maria

    2016-01-01

    Objectives for systems analysis capability: Develop integrated understanding of how a complex human physiological-socio-technical mission system behaves in spaceflight. Why? Support development of integrated solutions that prevent unwanted outcomes (Implementable approaches to minimize mission resources(mass, power, crew time, etc.)); Support development of tools for autonomy (need for exploration) (Assess and maintain resilience -individuals, teams, integrated system). Output of this exercise: -Representation of interfaces based on Human System Risk Board (HSRB) Risk Summary information and simple status based on Human Research Roadmap; Consolidated HSRB information applied to support communication; Point-of-Departure for HRP Element planning; Ability to track and communicate status of collaborations. 4

  12. The Systems Librarian: Re-Integrating the "Integrated" Library System

    ERIC Educational Resources Information Center

    Breeding, Marshall

    2005-01-01

    This article discusses the current environment of the ILS (Integrated Library System) plus add-ons tailored for electronic content and its future. It suggests that while the ILS may be mature, the supplemental products are not and the linkages among them are even less so. On the technical front, the recent interest in Web services gives reason to…

  13. Intelligent systems technology infrastructure for integrated systems

    NASA Technical Reports Server (NTRS)

    Lum, Henry, Jr.

    1991-01-01

    Significant advances have occurred during the last decade in intelligent systems technologies (a.k.a. knowledge-based systems, KBS) including research, feasibility demonstrations, and technology implementations in operational environments. Evaluation and simulation data obtained to date in real-time operational environments suggest that cost-effective utilization of intelligent systems technologies can be realized for Automated Rendezvous and Capture applications. The successful implementation of these technologies involve a complex system infrastructure integrating the requirements of transportation, vehicle checkout and health management, and communication systems without compromise to systems reliability and performance. The resources that must be invoked to accomplish these tasks include remote ground operations and control, built-in system fault management and control, and intelligent robotics. To ensure long-term evolution and integration of new validated technologies over the lifetime of the vehicle, system interfaces must also be addressed and integrated into the overall system interface requirements. An approach for defining and evaluating the system infrastructures including the testbed currently being used to support the on-going evaluations for the evolutionary Space Station Freedom Data Management System is presented and discussed. Intelligent system technologies discussed include artificial intelligence (real-time replanning and scheduling), high performance computational elements (parallel processors, photonic processors, and neural networks), real-time fault management and control, and system software development tools for rapid prototyping capabilities.

  14. The Human-Robot Interaction Operating System

    NASA Technical Reports Server (NTRS)

    Fong, Terrence; Kunz, Clayton; Hiatt, Laura M.; Bugajska, Magda

    2006-01-01

    In order for humans and robots to work effectively together, they need to be able to converse about abilities, goals and achievements. Thus, we are developing an interaction infrastructure called the "Human-Robot Interaction Operating System" (HRI/OS). The HRI/OS provides a structured software framework for building human-robot teams, supports a variety of user interfaces, enables humans and robots to engage in task-oriented dialogue, and facilitates integration of robots through an extensible API.

  15. Analyzing Human-Landscape Interactions: Tools That Integrate

    NASA Astrophysics Data System (ADS)

    Zvoleff, Alex; An, Li

    2014-01-01

    Humans have transformed much of Earth's land surface, giving rise to loss of biodiversity, climate change, and a host of other environmental issues that are affecting human and biophysical systems in unexpected ways. To confront these problems, environmental managers must consider human and landscape systems in integrated ways. This means making use of data obtained from a broad range of methods (e.g., sensors, surveys), while taking into account new findings from the social and biophysical science literatures. New integrative methods (including data fusion, simulation modeling, and participatory approaches) have emerged in recent years to address these challenges, and to allow analysts to provide information that links qualitative and quantitative elements for policymakers. This paper brings attention to these emergent tools while providing an overview of the tools currently in use for analysis of human-landscape interactions. Analysts are now faced with a staggering array of approaches in the human-landscape literature—in an attempt to bring increased clarity to the field, we identify the relative strengths of each tool, and provide guidance to analysts on the areas to which each tool is best applied. We discuss four broad categories of tools: statistical methods (including survival analysis, multi-level modeling, and Bayesian approaches), GIS and spatial analysis methods, simulation approaches (including cellular automata, agent-based modeling, and participatory modeling), and mixed-method techniques (such as alternative futures modeling and integrated assessment). For each tool, we offer an example from the literature of its application in human-landscape research. Among these tools, participatory approaches are gaining prominence for analysts to make the broadest possible array of information available to researchers, environmental managers, and policymakers. Further development of new approaches of data fusion and integration across sites or disciplines

  16. An integrative computational systems biology approach identifies differentially regulated dynamic transcriptome signatures which drive the initiation of human T helper cell differentiation

    PubMed Central

    2012-01-01

    Background A proper balance between different T helper (Th) cell subsets is necessary for normal functioning of the adaptive immune system. Revealing key genes and pathways driving the differentiation to distinct Th cell lineages provides important insight into underlying molecular mechanisms and new opportunities for modulating the immune response. Previous computational methods to quantify and visualize kinetic differential expression data of three or more lineages to identify reciprocally regulated genes have relied on clustering approaches and regression methods which have time as a factor, but have lacked methods which explicitly model temporal behavior. Results We studied transcriptional dynamics of human umbilical cord blood T helper cells cultured in absence and presence of cytokines promoting Th1 or Th2 differentiation. To identify genes that exhibit distinct lineage commitment dynamics and are specific for initiating differentiation to different Th cell subsets, we developed a novel computational methodology (LIGAP) allowing integrative analysis and visualization of multiple lineages over whole time-course profiles. Applying LIGAP to time-course data from multiple Th cell lineages, we identified and experimentally validated several differentially regulated Th cell subset specific genes as well as reciprocally regulated genes. Combining differentially regulated transcriptional profiles with transcription factor binding site and pathway information, we identified previously known and new putative transcriptional mechanisms involved in Th cell subset differentiation. All differentially regulated genes among the lineages together with an implementation of LIGAP are provided as an open-source resource. Conclusions The LIGAP method is widely applicable to quantify differential time-course dynamics of many types of datasets and generalizes to any number of conditions. It summarizes all the time-course measurements together with the associated uncertainty for

  17. Two integrable systems with integrals of motion of degree four

    NASA Astrophysics Data System (ADS)

    Tsiganov, A. V.

    2016-03-01

    We discuss the possibility of using second-order Killing tensors to construct Liouville-integrable Hamiltonian systems that are not Nijenhuis integrable. As an example, we consider two Killing tensors with a nonzero Haantjes torsion that satisfy weaker geometric conditions and also three-dimensional systems corresponding to them that are integrable in Euclidean space and have two quadratic integrals of motion and one fourth-order integral in momenta.

  18. Human Rights Education as an Integral Part of General Education

    NASA Astrophysics Data System (ADS)

    Hornberg, Sabine

    2002-07-01

    This article argues that human rights education should become an integral part of general education. The author discusses efforts to realise this aim within the German general educational system. She pays special attention to three areas. First, at the theoretical level, she examines how human rights education can be conceptualised within the context of general education and against the background of globalisation and multiculturalism. Second, she examines the political and administrative level, including questions of curriculum. Thirdly, she looks at the didactical aspect of human rights education. In conclusion she points out some of the implications for teacher training.

  19. Lunar materials processing system integration

    NASA Technical Reports Server (NTRS)

    Sherwood, Brent

    1992-01-01

    The theme of this paper is that governmental resources will not permit the simultaneous development of all viable lunar materials processing (LMP) candidates. Choices will inevitably be made, based on the results of system integration trade studies comparing candidates to each other for high-leverage applications. It is in the best long-term interest of the LMP community to lead the selection process itself, quickly and practically. The paper is in five parts. The first part explains what systems integration means and why the specialized field of LMP needs this activity now. The second part defines the integration context for LMP -- by outlining potential lunar base functions, their interrelationships and constraints. The third part establishes perspective for prioritizing the development of LMP methods, by estimating realistic scope, scale, and timing of lunar operations. The fourth part describes the use of one type of analytical tool for gaining understanding of system interactions: the input/output model. A simple example solved with linear algebra is used to illustrate. The fifth and closing part identifies specific steps needed to refine the current ability to study lunar base system integration. Research specialists have a crucial role to play now in providing the data upon which this refinement process must be based.

  20. Lunar materials processing system integration

    NASA Astrophysics Data System (ADS)

    Sherwood, Brent

    1992-02-01

    The theme of this paper is that governmental resources will not permit the simultaneous development of all viable lunar materials processing (LMP) candidates. Choices will inevitably be made, based on the results of system integration trade studies comparing candidates to each other for high-leverage applications. It is in the best long-term interest of the LMP community to lead the selection process itself, quickly and practically. The paper is in five parts. The first part explains what systems integration means and why the specialized field of LMP needs this activity now. The second part defines the integration context for LMP -- by outlining potential lunar base functions, their interrelationships and constraints. The third part establishes perspective for prioritizing the development of LMP methods, by estimating realistic scope, scale, and timing of lunar operations. The fourth part describes the use of one type of analytical tool for gaining understanding of system interactions: the input/output model. A simple example solved with linear algebra is used to illustrate. The fifth and closing part identifies specific steps needed to refine the current ability to study lunar base system integration. Research specialists have a crucial role to play now in providing the data upon which this refinement process must be based.

  1. Sensorimotor integration in human postural control

    NASA Technical Reports Server (NTRS)

    Peterka, R. J.

    2002-01-01

    It is generally accepted that human bipedal upright stance is achieved by feedback mechanisms that generate an appropriate corrective torque based on body-sway motion detected primarily by visual, vestibular, and proprioceptive sensory systems. Because orientation information from the various senses is not always available (eyes closed) or accurate (compliant support surface), the postural control system must somehow adjust to maintain stance in a wide variety of environmental conditions. This is the sensorimotor integration problem that we investigated by evoking anterior-posterior (AP) body sway using pseudorandom rotation of the visual surround and/or support surface (amplitudes 0.5-8 degrees ) in both normal subjects and subjects with severe bilateral vestibular loss (VL). AP rotation of body center-of-mass (COM) was measured in response to six conditions offering different combinations of available sensory information. Stimulus-response data were analyzed using spectral analysis to compute transfer functions and coherence functions over a frequency range from 0.017 to 2.23 Hz. Stimulus-response data were quite linear for any given condition and amplitude. However, overall behavior in normal subjects was nonlinear because gain decreased and phase functions sometimes changed with increasing stimulus amplitude. "Sensory channel reweighting" could account for this nonlinear behavior with subjects showing increasing reliance on vestibular cues as stimulus amplitudes increased. VL subjects could not perform this reweighting, and their stimulus-response behavior remained quite linear. Transfer function curve fits based on a simple feedback control model provided estimates of postural stiffness, damping, and feedback time delay. There were only small changes in these parameters with increasing visual stimulus amplitude. However, stiffness increased as much as 60% with increasing support surface amplitude. To maintain postural stability and avoid resonant behavior, an

  2. Integrated Systems Health Management for Intelligent Systems

    NASA Technical Reports Server (NTRS)

    Figueroa, Fernando; Melcher, Kevin

    2011-01-01

    The implementation of an integrated system health management (ISHM) capability is fundamentally linked to the management of data, information, and knowledge (DIaK) with the purposeful objective of determining the health of a system. It is akin to having a team of experts who are all individually and collectively observing and analyzing a complex system, and communicating effectively with each other in order to arrive at an accurate and reliable assessment of its health. In this paper, concepts, procedures, and approaches are presented as a foundation for implementing an intelligent systems ]relevant ISHM capability. The capability stresses integration of DIaK from all elements of a system. Both ground-based (remote) and on-board ISHM capabilities are compared and contrasted. The information presented is the result of many years of research, development, and maturation of technologies, and of prototype implementations in operational systems.

  3. Integrated Human Futures Modeling in Egypt

    SciTech Connect

    Passell, Howard D.; Aamir, Munaf Syed; Bernard, Michael Lewis; Beyeler, Walter E.; Fellner, Karen Marie; Hayden, Nancy Kay; Jeffers, Robert Fredric; Keller, Elizabeth James Kistin; Malczynski, Leonard A.; Mitchell, Michael David; Silver, Emily; Tidwell, Vincent C.; Villa, Daniel; Vugrin, Eric D.; Engelke, Peter; Burrow, Mat; Keith, Bruce

    2016-01-01

    The Integrated Human Futures Project provides a set of analytical and quantitative modeling and simulation tools that help explore the links among human social, economic, and ecological conditions, human resilience, conflict, and peace, and allows users to simulate tradeoffs and consequences associated with different future development and mitigation scenarios. In the current study, we integrate five distinct modeling platforms to simulate the potential risk of social unrest in Egypt resulting from the Grand Ethiopian Renaissance Dam (GERD) on the Blue Nile in Ethiopia. The five platforms simulate hydrology, agriculture, economy, human ecology, and human psychology/behavior, and show how impacts derived from development initiatives in one sector (e.g., hydrology) might ripple through to affect other sectors and how development and security concerns may be triggered across the region. This approach evaluates potential consequences, intended and unintended, associated with strategic policy actions that span the development-security nexus at the national, regional, and international levels. Model results are not intended to provide explicit predictions, but rather to provide system-level insight for policy makers into the dynamics among these interacting sectors, and to demonstrate an approach to evaluating short- and long-term policy trade-offs across different policy domains and stakeholders. The GERD project is critical to government-planned development efforts in Ethiopia but is expected to reduce downstream freshwater availability in the Nile Basin, fueling fears of negative social and economic impacts that could threaten stability and security in Egypt. We tested these hypotheses and came to the following preliminary conclusions. First, the GERD will have an important short-term impact on water availability, food production, and hydropower production in Egypt, depending on the short- term reservoir fill rate. Second, the GERD will have a very small impact on

  4. Fiber optic control system integration

    NASA Technical Reports Server (NTRS)

    Poppel, G. L.; Glasheen, W. M.; Russell, J. C.

    1987-01-01

    A total fiber optic, integrated propulsion/flight control system concept for advanced fighter aircraft is presented. Fiber optic technology pertaining to this system is identified and evaluated for application readiness. A fiber optic sensor vendor survey was completed, and the results are reported. The advantages of centralized/direct architecture are reviewed, and the concept of the protocol branch is explained. Preliminary protocol branch selections are made based on the F-18/F404 application. Concepts for new optical tools are described. Development plans for the optical technology and the described system are included.

  5. SSTAC/ARTS review of the draft Integrated Technology Plan (ITP). Volume 5: Human Support

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Viewgraphs of briefings from the Space Systems and Technology Advisory Committee (SSTAC)/ARTS review of the draft integrated technology plan (ITP) on human support are included. Topics covered include: human support program; human factors; life support technology; fire safety; medical support technology; advanced refrigeration technology; EVA suit system; advanced PLSS technology; and ARC-EVA systems research program.

  6. A Human-machine-interface Integrating Low-cost Sensors with a Neuromuscular Electrical Stimulation System for Post-stroke Balance Rehabilitation.

    PubMed

    Kumar, Deepesh; Das, Abhijit; Lahiri, Uttama; Dutta, Anirban

    2016-01-01

    A stroke is caused when an artery carrying blood from heart to an area in the brain bursts or a clot obstructs the blood flow to brain thereby preventing delivery of oxygen and nutrients. About half of the stroke survivors are left with some degree of disability. Innovative methodologies for restorative neurorehabilitation are urgently required to reduce long-term disability. The ability of the nervous system to reorganize its structure, function and connections as a response to intrinsic or extrinsic stimuli is called neuroplasticity. Neuroplasticity is involved in post-stroke functional disturbances, but also in rehabilitation. Beneficial neuroplastic changes may be facilitated with non-invasive electrotherapy, such as neuromuscular electrical stimulation (NMES) and sensory electrical stimulation (SES). NMES involves coordinated electrical stimulation of motor nerves and muscles to activate them with continuous short pulses of electrical current while SES involves stimulation of sensory nerves with electrical current resulting in sensations that vary from barely perceivable to highly unpleasant. Here, active cortical participation in rehabilitation procedures may be facilitated by driving the non-invasive electrotherapy with biosignals (electromyogram (EMG), electroencephalogram (EEG), electrooculogram (EOG)) that represent simultaneous active perception and volitional effort. To achieve this in a resource-poor setting, e.g., in low- and middle-income countries, we present a low-cost human-machine-interface (HMI) by leveraging recent advances in off-the-shelf video game sensor technology. In this paper, we discuss the open-source software interface that integrates low-cost off-the-shelf sensors for visual-auditory biofeedback with non-invasive electrotherapy to assist postural control during balance rehabilitation. We demonstrate the proof-of-concept on healthy volunteers. PMID:27166666

  7. Integrated nonthermal treatment system study

    SciTech Connect

    Biagi, C.; Bahar, D.; Teheranian, B.; Vetromile, J.; Quapp, W.J.; Bechtold, T.; Brown, B.; Schwinkendorf, W.; Swartz, G.

    1997-01-01

    This report presents the results of a study of nonthermal treatment technologies. The study consisted of a systematic assessment of five nonthermal treatment alternatives. The treatment alternatives consist of widely varying technologies for safely destroying the hazardous organic components, reducing the volume, and preparing for final disposal of the contact-handled mixed low-level waste (MLLW) currently stored in the US Department of Energy complex. The alternatives considered were innovative nonthermal treatments for organic liquids and sludges, process residue, soil and debris. Vacuum desorption or various washing approaches are considered for treatment of soil, residue and debris. Organic destruction methods include mediated electrochemical oxidation, catalytic wet oxidation, and acid digestion. Other methods studied included stabilization technologies and mercury separation of treatment residues. This study is a companion to the integrated thermal treatment study which examined 19 alternatives for thermal treatment of MLLW waste. The quantities and physical and chemical compositions of the input waste are based on the inventory database developed by the US Department of Energy. The Integrated Nonthermal Treatment Systems (INTS) systems were evaluated using the same waste input (2,927 pounds per hour) as the Integrated Thermal Treatment Systems (ITTS). 48 refs., 68 figs., 37 tabs.

  8. Human Exploration Spacecraft Testbed for Integration and Advancement (HESTIA)

    NASA Technical Reports Server (NTRS)

    Banker, Brian F.; Robinson, Travis

    2016-01-01

    The proposed paper will cover ongoing effort named HESTIA (Human Exploration Spacecraft Testbed for Integration and Advancement), led at the National Aeronautics and Space Administration (NASA) Johnson Space Center (JSC) to promote a cross-subsystem approach to developing Mars-enabling technologies with the ultimate goal of integrated system optimization. HESTIA also aims to develop the infrastructure required to rapidly test these highly integrated systems at a low cost. The initial focus is on the common fluids architecture required to enable human exploration of mars, specifically between life support and in-situ resource utilization (ISRU) subsystems. An overview of the advancements in both integrated technologies, in infrastructure, in simulation, and in modeling capabilities will be presented, as well as the results and findings of integrated testing,. Due to the enormous mass gear-ratio required for human exploration beyond low-earth orbit, (for every 1 kg of payload landed on Mars, 226 kg will be required on Earth), minimization of surface hardware and commodities is paramount. Hardware requirements can be minimized by reduction of equipment performing similar functions though for different subsystems. If hardware could be developed which meets the requirements of both life support and ISRU it could result in the reduction of primary hardware and/or reduction in spares. Minimization of commodities to the surface of mars can be achieved through the creation of higher efficiency systems producing little to no undesired waste, such as a closed-loop life support subsystem. Where complete efficiency is impossible or impractical, makeup commodities could be manufactured via ISRU. Although, utilization of ISRU products (oxygen and water) for crew consumption holds great promise of reducing demands on life support hardware, there exist concerns as to the purity and transportation of commodities. To date, ISRU has been focused on production rates and purities for

  9. Human-system Interfaces for Automatic Systems

    SciTech Connect

    OHara, J.M.; Higgins,J.; Fleger, S.; Barnes V.

    2010-11-07

    Automation is ubiquitous in modern complex systems, and commercial nuclear- power plants are no exception. Automation is applied to a wide range of functions including monitoring and detection, situation assessment, response planning, and response implementation. Automation has become a 'team player' supporting personnel in nearly all aspects of system operation. In light of its increasing use and importance in new- and future-plants, guidance is needed to conduct safety reviews of the operator's interface with automation. The objective of this research was to develop such guidance. We first characterized the important HFE aspects of automation, including six dimensions: levels, functions, processes, modes, flexibility, and reliability. Next, we reviewed literature on the effects of all of these aspects of automation on human performance, and on the design of human-system interfaces (HSIs). Then, we used this technical basis established from the literature to identify general principles for human-automation interaction and to develop review guidelines. The guidelines consist of the following seven topics: automation displays, interaction and control, automation modes, automation levels, adaptive automation, error tolerance and failure management, and HSI integration. In addition, our study identified several topics for additional research.

  10. Rendezvous Integration Complexities of NASA Human Flight Vehicles

    NASA Technical Reports Server (NTRS)

    Brazzel, Jack P.; Goodman, John L.

    2009-01-01

    Propellant-optimal trajectories, relative sensors and navigation, and docking/capture mechanisms are rendezvous disciplines that receive much attention in the technical literature. However, other areas must be considered. These include absolute navigation, maneuver targeting, attitude control, power generation, software development and verification, redundancy management, thermal control, avionics integration, robotics, communications, lighting, human factors, crew timeline, procedure development, orbital debris risk mitigation, structures, plume impingement, logistics, and in some cases extravehicular activity. While current and future spaceflight programs will introduce new technologies and operations concepts, the complexity of integrating multiple systems on multiple spacecraft will remain. The systems integration task may become more difficult as increasingly complex software is used to meet current and future automation, autonomy, and robotic operation requirements.

  11. Autonomous power system: Integrated scheduling

    NASA Technical Reports Server (NTRS)

    Ringer, Mark J.

    1992-01-01

    The Autonomous Power System (APS) project at NASA Lewis Research Center is designed to demonstrate the abilities of integrated intelligent diagnosis, control and scheduling techniques to space power distribution hardware. The project consists of three elements: the Autonomous Power Expert System (APEX) for fault diagnosis, isolation, and recovery (FDIR), the Autonomous Intelligent Power Scheduler (AIPS) to determine system configuration, and power hardware (Brassboard) to simulate a space-based power system. Faults can be introduced into the Brassboard and in turn, be diagnosed and corrected by APEX and AIPS. The Autonomous Intelligent Power Scheduler controls the execution of loads attached to the Brassboard. Each load must be executed in a manner that efficiently utilizes available power and satisfies all load, resource, and temporal constraints. In the case of a fault situation on the Brassboard, AIPS dynamically modifies the existing schedule in order to resume efficient operation conditions. A database is kept of the power demand, temporal modifiers, priority of each load, and the power level of each source. AIPS uses a set of heuristic rules to assign start times and resources to each load based on load and resource constraints. A simple improvement engine based upon these heuristics is also available to improve the schedule efficiency. This paper describes the operation of the Autonomous Intelligent Power Scheduler as a single entity, as well as its integration with APEX and the Brassboard. Future plans are discussed for the growth of the Autonomous Intelligent Power Scheduler.

  12. Information Security and Integrity Systems

    NASA Technical Reports Server (NTRS)

    1990-01-01

    Viewgraphs from the Information Security and Integrity Systems seminar held at the University of Houston-Clear Lake on May 15-16, 1990 are presented. A tutorial on computer security is presented. The goals of this tutorial are the following: to review security requirements imposed by government and by common sense; to examine risk analysis methods to help keep sight of forest while in trees; to discuss the current hot topic of viruses (which will stay hot); to examine network security, now and in the next year to 30 years; to give a brief overview of encryption; to review protection methods in operating systems; to review database security problems; to review the Trusted Computer System Evaluation Criteria (Orange Book); to comment on formal verification methods; to consider new approaches (like intrusion detection and biometrics); to review the old, low tech, and still good solutions; and to give pointers to the literature and to where to get help. Other topics covered include security in software applications and development; risk management; trust: formal methods and associated techniques; secure distributed operating system and verification; trusted Ada; a conceptual model for supporting a B3+ dynamic multilevel security and integrity in the Ada runtime environment; and information intelligence sciences.

  13. Integrated Deployment and the Energy Systems Integration Facility: Workshop Proceedings

    SciTech Connect

    Kroposki, B.; Werner, M.; Spikes, A.; Komomua, C.

    2013-01-01

    This report summarizes the workshop entitled: Integrated Deployment and the Energy Systems Integration Facility. In anticipation of the opening of the ESIF, NREL held the workshop August 21-23, 2012 and invited participants from utilities, government, industry, and academia to discuss renewable integration challenges and discover new ways to meet them by taking advantage of the ESIF's capabilities.

  14. Policy Interactions in Human-Landscape Systems

    NASA Astrophysics Data System (ADS)

    Gerlak, Andrea K.

    2014-01-01

    Given the heightened pace and extent of human interactions with landscapes, there is increasing recognition of the interdependence of hydrogeomorphological, ecological, and human systems in understanding human-landscape interactions. There is also widespread agreement for greater integration across disciplinary boundaries to generate new knowledge urgently needed for theory building to understand, predict, and respond to rapidly changing human-landscape systems. The development of new conceptual frameworks, methods, tools, and collaborations linking across the natural and social sciences are key elements to such integration. In an effort to contribute to a broader conceptual framework for human-landscape systems, this paper describes how environmental policy research has contributed to four integrative themes—thresholds and tipping points; spatial scales and boundaries; feedback loops; and time scales and lags—developed by participants in an NSF-sponsored interdisciplinary workshop. As a broad and heterogeneous body of literature, environmental policy research reflects a diversity of methodological and theoretical approaches around institutions, actors, processes, and ideas. We integrate across multiple subfields and research programs to help identify complementarities in research that may support future interdisciplinary collaborative work. We conclude with a discussion of future research questions to help advance greater interdisciplinary research around human-landscape systems.

  15. Integrated Energy System Dispatch Optimization

    SciTech Connect

    Firestone, Ryan; Stadler, Michael; Marnay, Chris

    2006-06-16

    On-site cogeneration of heat and electricity, thermal and electrical storage, and curtailing/rescheduling demand options are often cost-effective to commercial and industrial sites. This collection of equipment and responsive consumption can be viewed as an integrated energy system(IES). The IES can best meet the sites cost or environmental objectives when controlled in a coordinated manner. However, continuously determining this optimal IES dispatch is beyond the expectations for operators of smaller systems. A new algorithm is proposed in this paper to approximately solve the real-time dispatch optimization problem for a generic IES containing an on-site cogeneration system subject to random outages, limited curtailment opportunities, an intermittent renewable electricity source, and thermal storage. An example demonstrates how this algorithm can be used in simulation to estimate the value of IES components.

  16. Integrity in flight control systems

    NASA Technical Reports Server (NTRS)

    Kurzhals, P. R.; Deloach, R.

    1977-01-01

    In connection with advances in technology, mainly in the electronic area, aircraft flight control applications have evolved from simple pilot-relief autopilots to flight-critical and redundant fly-by-wire and active control systems. For flight-critical implementations which required accommodation of inflight failures, additional levels of redundancy were incorporated to provide fail-safe and fail-operative performance. The current status of flight control systems reliability is examined and high-reliability approaches are discussed. Attention is given to the design of ring laser gyros and magnetohydrodynamic rate sensors, redundancy configurations for component failure protection, improvements of hydraulic actuators made on the component level, integrated actuators, problems of software reliability, lightning considerations, and failure detection methods for component and system failures.

  17. Integrated risk information system (IRIS)

    SciTech Connect

    Tuxen, L.

    1990-12-31

    The Integrated Risk Information System (IRIS) is an electronic information system developed by the US Environmental Protection Agency (EPA) containing information related to health risk assessment. IRIS is the Agency`s primary vehicle for communication of chronic health hazard information that represents Agency consensus following comprehensive review by intra-Agency work groups. The original purpose for developing IRIS was to provide guidance to EPA personnel in making risk management decisions. This original purpose for developing IRIS was to guidance to EPA personnel in making risk management decisions. This role has expanded and evolved with wider access and use of the system. IRIS contains chemical-specific information in summary format for approximately 500 chemicals. IRIS is available to the general public on the National Library of Medicine`s Toxicology Data Network (TOXNET) and on diskettes through the National Technical Information Service (NTIS).

  18. Integrated Systems Health Management for Intelligent Systems

    NASA Technical Reports Server (NTRS)

    Figueroa, Fernando; Melcher, Kevin

    2011-01-01

    The implementation of an integrated system health management (ISHM) capability is fundamentally linked to the management of data, information, and knowledge (DIaK) with the purposeful objective of determining the health of a system. Management implies storage, distribution, sharing, maintenance, processing, reasoning, and presentation. ISHM is akin to having a team of experts who are all individually and collectively observing and analyzing a complex system, and communicating effectively with each other in order to arrive at an accurate and reliable assessment of its health. In this chapter, concepts, procedures, and approaches are presented as a foundation for implementing an ISHM capability relevant to intelligent systems. The capability stresses integration of DIaK from all elements of a system, emphasizing an advance toward an on-board, autonomous capability. Both ground-based and on-board ISHM capabilities are addressed. The information presented is the result of many years of research, development, and maturation of technologies, and of prototype implementations in operational systems.

  19. CLIPS: The C language integrated production system

    NASA Technical Reports Server (NTRS)

    Riley, Gary

    1994-01-01

    Expert systems are computer programs which emulate human expertise in well defined problem domains. The potential payoff from expert systems is high: valuable expertise can be captured and preserved, repetitive and/or mundane tasks requiring human expertise can be automated, and uniformity can be applied in decision making processes. The C Language Integrated Production System (CLIPS) is an expert system building tool, developed at the Johnson Space Center, which provides a complete environment for the development and delivery of rule and/or object based expert systems. CLIPS was specifically designed to provide a low cost option for developing and deploying expert system applications across a wide range of hardware platforms. The commercial potential of CLIPS is vast. Currently, CLIPS is being used by over 5,000 individuals throughout the public and private sector. Because the CLIPS source code is readily available, numerous groups have used CLIPS as the basis for their own expert system tools. To date, three commercially available tools have been derived from CLIPS. In general, the development of CLIPS has helped to improve the ability to deliver expert system technology throughout the public and private sectors for a wide range of applications and diverse computing environments.

  20. Integrated multisensor perimeter detection systems

    NASA Astrophysics Data System (ADS)

    Kent, P. J.; Fretwell, P.; Barrett, D. J.; Faulkner, D. A.

    2007-10-01

    The report describes the results of a multi-year programme of research aimed at the development of an integrated multi-sensor perimeter detection system capable of being deployed at an operational site. The research was driven by end user requirements in protective security, particularly in threat detection and assessment, where effective capability was either not available or prohibitively expensive. Novel video analytics have been designed to provide robust detection of pedestrians in clutter while new radar detection and tracking algorithms provide wide area day/night surveillance. A modular integrated architecture based on commercially available components has been developed. A graphical user interface allows intuitive interaction and visualisation with the sensors. The fusion of video, radar and other sensor data provides the basis of a threat detection capability for real life conditions. The system was designed to be modular and extendable in order to accommodate future and legacy surveillance sensors. The current sensor mix includes stereoscopic video cameras, mmWave ground movement radar, CCTV and a commercially available perimeter detection cable. The paper outlines the development of the system and describes the lessons learnt after deployment in a pilot trial.

  1. DENdb: database of integrated human enhancers

    PubMed Central

    Ashoor, Haitham; Kleftogiannis, Dimitrios; Radovanovic, Aleksandar; Bajic, Vladimir B.

    2015-01-01

    Enhancers are cis-acting DNA regulatory regions that play a key role in distal control of transcriptional activities. Identification of enhancers, coupled with a comprehensive functional analysis of their properties, could improve our understanding of complex gene transcription mechanisms and gene regulation processes in general. We developed DENdb, a centralized on-line repository of predicted enhancers derived from multiple human cell-lines. DENdb integrates enhancers predicted by five different methods generating an enriched catalogue of putative enhancers for each of the analysed cell-lines. DENdb provides information about the overlap of enhancers with DNase I hypersensitive regions, ChIP-seq regions of a number of transcription factors and transcription factor binding motifs, means to explore enhancer interactions with DNA using several chromatin interaction assays and enhancer neighbouring genes. DENdb is designed as a relational database that facilitates fast and efficient searching, browsing and visualization of information. Database URL: http://www.cbrc.kaust.edu.sa/dendb/ PMID:26342387

  2. Human portable preconcentrator system

    DOEpatents

    Linker, Kevin L.; Bouchier, Francis A.; Hannum, David W.; Rhykerd, Jr., Charles L.

    2003-01-01

    A preconcentrator system and apparatus suited to human portable use wherein sample potentially containing a target chemical substance is drawn into a chamber and through a pervious screen. The screen is adapted to capture target chemicals and then, upon heating, to release those chemicals into the chamber. Chemicals captured and then released in this fashion are then carried to a portable chemical detection device such as a portable ion mobility spectrometer. In the preferred embodiment, the means for drawing sample into the chamber comprises a reversible fan which, when operated in reverse direction, creates a backpressure that facilitates evolution of captured target chemicals into the chamber when the screen is heated.

  3. Human Factors, Habitability and Environmental Health and the Human Integration Design Handbook. Volume 2

    NASA Technical Reports Server (NTRS)

    Houbec, Keith; Tillman, Barry; Connolly, Janis

    2010-01-01

    For decades, Space Life Sciences and NASA as an Agency have considered NASA-STD-3000, Man-Systems Integration Standards, a significant contribution to human spaceflight programs and to human-systems integration in general. The document has been referenced in numerous design standards both within NASA and by organizations throughout the world. With research program and project results being realized, advances in technology and new information in a variety of topic areas now available, the time arrived to update this extensive suite of requirements and design information. During the past several years, a multi-NASA center effort has been underway to write the update to NASA-STD-3000 with standards and design guidance that would be applicable to all future human spaceflight programs. NASA-STD-3001 - Volumes 1 and 2 - and the Human Integration Design Handbook (HIDH) were created. Volume 1, Crew Health, establishes NASA s spaceflight crew health standards for the pre-flight, in-flight, and post-flight phases of human spaceflight. Volume 2, Human Factors, Habitability and Environmental Health, focuses on the requirements of human-system integration and how the human crew interacts with other systems, and how the human and the system function together to accomplish the tasks for mission success. The HIDH is a compendium of human spaceflight history and knowledge, and provides useful background information and research findings. And as the HIDH is a stand-alone companion to the Standards, the maintenance of the document has been streamlined. This unique and flexible approach ensures that the content is current and addresses the fundamental advances of human performance and human capabilities and constraints research. Current work focuses on the development of new sections of Volume 2 and collecting updates to the HIDH. The new sections in development expand the scope of the standard and address mission operations and support operations. This effort is again collaboration

  4. Integrated Human Test Facilities at NASA and the Role of Human Engineering

    NASA Technical Reports Server (NTRS)

    Tri, Terry O.

    2002-01-01

    Integrated human test facilities are a key component of NASA's Advanced Life Support Program (ALSP). Over the past several years, the ALSP has been developing such facilities to serve as a large-scale advanced life support and habitability test bed capable of supporting long-duration evaluations of integrated bioregenerative life support systems with human test crews. These facilities-targeted for evaluation of hypogravity compatible life support and habitability systems to be developed for use on planetary surfaces-are currently in the development stage at the Johnson Space Center. These major test facilities are comprised of a set of interconnected chambers with a sealed internal environment, which will be outfitted with systems capable of supporting test crews of four individuals for periods exceeding one year. The advanced technology systems to be tested will consist of both biological and physicochemical components and will perform all required crew life support and habitability functions. This presentation provides a description of the proposed test "missions" to be supported by these integrated human test facilities, the overall system architecture of the facilities, the current development status of the facilities, and the role that human design has played in the development of the facilities.

  5. Visuospatial integration and human evolution: the fossil evidence.

    PubMed

    Bruner, Emiliano; Lozano, Marina; Lorenzo, Carlos

    2016-06-20

    Visuospatial integration concerns the ability to coordinate the inner and outer environments, namely the central nervous system and the outer spatial elements, through the interface of the body. This integration is essential for every basic human activity, from locomotion and grasping to speech or tooling. Visuospatial integration is even more fundamental when dealing with theories on extended mind, embodiment, and material engagement. According to the hypotheses on extended cognition, the nervous system, the body and the external objects work as a single integrated unit, and what we call "mind" is the process resulting from such interaction. Because of the relevance of culture and material culture in humans, important changes in such processes were probably crucial for the evolution of Homo sapiens. Much information in this sense can be supplied by considering issues in neuroarchaeology and cognitive sciences. Nonetheless, fossils and their anatomy can also provide evidence according to changes involving physical and body aspects. In this article, we review three sources of morphological information concerning visuospatial management and fossils: evolutionary neuroanatomy, manipulative behaviors, and hand evolution. PMID:26829574

  6. Human Rights Education Can Be Integrated throughout the School Day

    ERIC Educational Resources Information Center

    Childhood Education, 2005

    2005-01-01

    Research indicates that few state departments of education have actually mandated human rights education in their schools. Clearly, individual teachers will need to take responsibility for the integration of peace education and human rights education. By integrating human rights education and peace education into the daily fabric of the school…

  7. Apollo cryogenic integrated systems program

    NASA Technical Reports Server (NTRS)

    Seto, R. K. M.; Cunningham, J. E.

    1971-01-01

    The integrated systems program is capable of simulating both nominal and anomalous operation of the Apollo cryogenics storage system (CSS). Two versions of the program exist; one for the Apollo 14 configuration and the other for J Type Mission configurations. The program consists of two mathematical models which are dynamically coupled. A model of the CSS components and lines determines the oxygen and hydrogen flowrate from each storage tank given the tank pressures and temperatures, and the electrical power subsystem and environmental control subsystem flow demands. Temperatures and pressures throughout the components and lines are also determined. A model of the CSS tankage determines the pressure and temperatures in the tanks given the flowrate from each tank and the thermal environment. The model accounts for tank stretch and includes simplified oxygen tank heater and stratification routines. The program is currently operational on the Univac 1108 computer.

  8. Integrated control system and method

    SciTech Connect

    Wang, Paul Sai Keat; Baldwin, Darryl; Kim, Myoungjin

    2013-10-29

    An integrated control system for use with an engine connected to a generator providing electrical power to a switchgear is disclosed. The engine receives gas produced by a gasifier. The control system includes an electronic controller associated with the gasifier, engine, generator, and switchgear. A gas flow sensor monitors a gas flow from the gasifier to the engine through an engine gas control valve and provides a gas flow signal to the electronic controller. A gas oversupply sensor monitors a gas oversupply from the gasifier and provides an oversupply signal indicative of gas not provided to the engine. A power output sensor monitors a power output of the switchgear and provide a power output signal. The electronic controller changes gas production of the gasifier and the power output rating of the switchgear based on the gas flow signal, the oversupply signal, and the power output signal.

  9. The "What Is a System" Reflection Interview as a Knowledge Integration Activity for High School Students' Understanding of Complex Systems in Human Biology

    ERIC Educational Resources Information Center

    Tripto, Jaklin; Ben-Zvi Assaraf, Orit; Snapir, Zohar; Amit, Miriam

    2016-01-01

    This study examined the reflection interview as a tool for assessing and facilitating the use of "systems language" amongst 11th grade students who have recently completed their first year of high school biology. Eighty-three students composed two concept maps in the 10th grade--one at the beginning of the school year and one at its end.…

  10. Integrated roof wind energy system

    NASA Astrophysics Data System (ADS)

    Suma, A. B.; Ferraro, R. M.; Dano, B.; Moonen, S. P. G.

    2012-10-01

    Wind is an attractive renewable source of energy. Recent innovations in research and design have reduced to a few alternatives with limited impact on residential construction. Cost effective solutions have been found at larger scale, but storage and delivery of energy to the actual location it is used, remain a critical issue. The Integrated Roof Wind Energy System is designed to overcome the current issues of urban and larger scale renewable energy system. The system is built up by an axial array of skewed shaped funnels that make use of the Venturi Effect to accelerate the wind flow. This inventive use of shape and geometry leads to a converging air capturing inlet to create high wind mass flow and velocity toward a vertical-axis wind turbine in the top of the roof for generation of a relatively high amount of energy. The methods used in this overview of studies include an array of tools from analytical modelling, PIV wind tunnel testing, and CFD simulation studies. The results define the main design parameters for an efficient system, and show the potential for the generation of high amounts of renewable energy with a novel and effective system suited for the built environment.

  11. Advanced integrated life support system update

    NASA Technical Reports Server (NTRS)

    Whitley, Phillip E.

    1994-01-01

    The Advanced Integrated Life Support System Program (AILSS) is an advanced development effort to integrate the life support and protection requirements using the U.S. Navy's fighter/attack mission as a starting point. The goal of AILSS is to optimally mate protection from altitude, acceleration, chemical/biological agent, thermal environment (hot, cold, and cold water immersion) stress as well as mission enhancement through improved restraint, night vision, and head-mounted reticules and displays to ensure mission capability. The primary emphasis to date has been to establish garment design requirements and tradeoffs for protection. Here the garment and the human interface are treated as a system. Twelve state-off-the-art concepts from government and industry were evaluated for design versus performance. On the basis of a combination of centrifuge, thermal manikin data, thermal modeling, and mobility studies, some key design parameters have been determined. Future efforts will concentrate on the integration of protection through garment design and the use of a single layer, multiple function concept to streamline the garment system.

  12. Simulating Humans as Integral Parts of Spacecraft Missions

    NASA Technical Reports Server (NTRS)

    Bruins, Anthony C.; Rice, Robert; Nguyen, Lac; Nguyen, Heidi; Saito, Tim; Russell, Elaine

    2006-01-01

    The Collaborative-Virtual Environment Simulation Tool (C-VEST) software was developed for use in a NASA project entitled "3-D Interactive Digital Virtual Human." The project is oriented toward the use of a comprehensive suite of advanced software tools in computational simulations for the purposes of human-centered design of spacecraft missions and of the spacecraft, space suits, and other equipment to be used on the missions. The C-VEST software affords an unprecedented suite of capabilities for three-dimensional virtual-environment simulations with plug-in interfaces for physiological data, haptic interfaces, plug-and-play software, realtime control, and/or playback control. Mathematical models of the mechanics of the human body and of the aforementioned equipment are implemented in software and integrated to simulate forces exerted on and by astronauts as they work. The computational results can then support the iterative processes of design, building, and testing in applied systems engineering and integration. The results of the simulations provide guidance for devising measures to counteract effects of microgravity on the human body and for the rapid development of virtual (that is, simulated) prototypes of advanced space suits, cockpits, and robots to enhance the productivity, comfort, and safety of astronauts. The unique ability to implement human-in-the-loop immersion also makes the C-VEST software potentially valuable for use in commercial and academic settings beyond the original space-mission setting.

  13. Intelligent systems technology infrastructure for integrated systems

    NASA Technical Reports Server (NTRS)

    Lum, Henry

    1991-01-01

    A system infrastructure must be properly designed and integrated from the conceptual development phase to accommodate evolutionary intelligent technologies. Several technology development activities were identified that may have application to rendezvous and capture systems. Optical correlators in conjunction with fuzzy logic control might be used for the identification, tracking, and capture of either cooperative or non-cooperative targets without the intensive computational requirements associated with vision processing. A hybrid digital/analog system was developed and tested with a robotic arm. An aircraft refueling application demonstration is planned within two years. Initially this demonstration will be ground based with a follow-on air based demonstration. System dependability measurement and modeling techniques are being developed for fault management applications. This involves usage of incremental solution/evaluation techniques and modularized systems to facilitate reuse and to take advantage of natural partitions in system models. Though not yet commercially available and currently subject to accuracy limitations, technology is being developed to perform optical matrix operations to enhance computational speed. Optical terrain recognition using camera image sequencing processed with optical correlators is being developed to determine position and velocity in support of lander guidance. The system is planned for testing in conjunction with Dryden Flight Research Facility. Advanced architecture technology is defining open architecture design constraints, test bed concepts (processors, multiple hardware/software and multi-dimensional user support, knowledge/tool sharing infrastructure), and software engineering interface issues.

  14. Morphological Integration of the Modern Human Mandible during Ontogeny

    PubMed Central

    Polanski, Joshua M.

    2011-01-01

    Craniofacial integration is prevalent in anatomical modernity research. Little investigation has been done on mandibular integration. Integration patterns were quantified in a longitudinal modern human sample of mandibles. This integration pattern is one of modularization between the alveolar and muscle attachment regions, but with age-specific differences. The ascending ramus and nonalveolar portions of the corpus remain integrated throughout ontogeny. The alveolar region is dynamic, becoming modularized according to the needs of the mandible at a particular developmental stage. Early in ontogeny, this modularity reflects the need for space for the developing dentition; later, modularity is more reflective of mastication. The overall pattern of modern human mandibular integration follows the integration pattern seen in other mammals, including chimpanzees. Given the differences in craniofacial integration patterns between humans and chimpanzees, but the similarities in mandibular integration, it is likely that the mandible has played the more passive role in hominin skull evolution. PMID:21716741

  15. WRATS Integrated Data Acquisition System

    NASA Technical Reports Server (NTRS)

    Piatak, David J.

    2008-01-01

    The Wing and Rotor Aeroelastic Test System (WRATS) data acquisition system (DAS) is a 64-channel data acquisition display and analysis system specifically designed for use with the WRATS 1/5-scale V-22 tiltrotor model of the Bell Osprey. It is the primary data acquisition system for experimental aeroelastic testing of the WRATS model for the purpose of characterizing the aeromechanical and aeroelastic stability of prototype tiltrotor configurations. The WRATS DAS was also used during aeroelastic testing of Bell Helicopter Textron s Quad-Tiltrotor (QTR) design concept, a test which received international attention. The LabVIEW-based design is portable and capable of powering and conditioning over 64 channels of dynamic data at sampling rates up to 1,000 Hz. The system includes a 60-second circular data archive, an integrated model swashplate excitation system, a moving block damping application for calculation of whirl flutter mode subcritical damping, a loads and safety monitor, a pilot-control console display, data analysis capabilities, and instrumentation calibration functions. Three networked computers running custom-designed LabVIEW software acquire data through National Instruments data acquisition hardware. The aeroelastic model (see figure) was tested with the DAS at two facilities at NASA Langley, the Transonic Dynamics Tunnel (TDT) and the Rotorcraft Hover Test Facility (RHTF). Because of the need for seamless transition between testing at these facilities, DAS is portable. The software is capable of harmonic analysis of periodic time history data, Fast Fourier Transform calculations, power spectral density calculations, and on-line calibration of test instrumentation. DAS has a circular buffer archive to ensure critical data is not lost in event of model failure/incident, as well as a sample-and-hold capability for phase-correct time history data.

  16. Human portable preconcentrator system

    DOEpatents

    Linker, Kevin L.; Brusseau, Charles A.; Hannum, David W.; Puissant, James G.; Varley, Nathan R.

    2003-08-12

    A preconcentrator system and apparatus suited to human portable use wherein sample potentially containing a target chemical substance is drawn into a chamber and through a pervious screen. The screen is adapted to capture target chemicals and then, upon heating, to release those chemicals into the chamber. Chemicals captured and then released in this fashion are then carried to a portable chemical detection device such as a portable ion mobility spectrometer. In the preferred embodiment, the means for drawing sample into the chamber comprises a reversible fan which, when operated in reverse direction, creates a backpressure that facilitates evolution of captured target chemicals into the chamber when the screen is heated. The screen can be positioned directly in front of the detector prior to heating to improve detection capability.

  17. Integrated delivery systems. Evolving oligopolies.

    PubMed

    Malone, T A

    1998-01-01

    The proliferation of Integrated Delivery Systems (IDSs) in regional health care markets has resulted in the movement of these markets from a monopolistic competitive model of behavior to an oligopoly. An oligopoly is synonymous with competition among the few, as a small number of firms supply a dominant share of an industry's total output. The basic characteristics of a market with competition among the few are: (1) A mutual interdependence among the actions and behaviors of competing firms; (2) competition tends to rely on the differentiation of products; (3) significant barriers to entering the market exist; (4) the demand curve for services may be kinked; and (5) firms can benefit from economies of scale. An understanding of these characteristics is essential to the survival of IDSs as regional managed care markets mature. PMID:10180497

  18. Integrated solar energy system optimization

    NASA Astrophysics Data System (ADS)

    Young, S. K.

    1982-11-01

    The computer program SYSOPT, intended as a tool for optimizing the subsystem sizing, performance, and economics of integrated wind and solar energy systems, is presented. The modular structure of the methodology additionally allows simulations when the solar subsystems are combined with conventional technologies, e.g., a utility grid. Hourly energy/mass flow balances are computed for interconnection points, yielding optimized sizing and time-dependent operation of various subsystems. The program requires meteorological data, such as insolation, diurnal and seasonal variations, and wind speed at the hub height of a wind turbine, all of which can be taken from simulations like the TRNSYS program. Examples are provided for optimization of a solar-powered (wind turbine and parabolic trough-Rankine generator) desalinization plant, and a design analysis for a solar powered greenhouse.

  19. Electronic integrated disease surveillance system and pathogen asset control system.

    PubMed

    Wahl, Tom G; Burdakov, Aleksey V; Oukharov, Andrey O; Zhilokov, Azamat K

    2012-01-01

    Electronic Integrated Disease Surveillance System (EIDSS) has been used to strengthen and support monitoring and prevention of dangerous diseases within One Health concept by integrating veterinary and human surveillance, passive and active approaches, case-based records including disease-specific clinical data based on standardised case definitions and aggregated data, laboratory data including sample tracking linked to each case and event with test results and epidemiological investigations. Information was collected and shared in secure way by different means: through the distributed nodes which are continuously synchronised amongst each other, through the web service, through the handheld devices. Electronic Integrated Disease Surveillance System provided near real time information flow that has been then disseminated to the appropriate organisations in a timely manner. It has been used for comprehensive analysis and visualisation capabilities including real time mapping of case events as these unfold enhancing decision making. Electronic Integrated Disease Surveillance System facilitated countries to comply with the IHR 2005 requirements through a data transfer module reporting diseases electronically to the World Health Organisation (WHO) data center as well as establish authorised data exchange with other electronic system using Open Architecture approach. Pathogen Asset Control System (PACS) has been used for accounting, management and control of biological agent stocks. Information on samples and strains of any kind throughout their entire lifecycle has been tracked in a comprehensive and flexible solution PACS.Both systems have been used in a combination and individually. Electronic Integrated Disease Surveillance System and PACS are currently deployed in the Republics of Kazakhstan, Georgia and Azerbaijan as a part of the Cooperative Biological Engagement Program (CBEP) sponsored by the US Defense Threat Reduction Agency (DTRA). PMID:23327375

  20. Advanced integrated solvent extraction systems

    SciTech Connect

    Horwitz, E.P.; Dietz, M.L.; Leonard, R.A.

    1997-10-01

    Advanced integrated solvent extraction systems are a series of novel solvent extraction (SX) processes that will remove and recover all of the major radioisotopes from acidic-dissolved sludge or other acidic high-level wastes. The major focus of this effort during the last 2 years has been the development of a combined cesium-strontium extraction/recovery process, the Combined CSEX-SREX Process. The Combined CSEX-SREX Process relies on a mixture of a strontium-selective macrocyclic polyether and a novel cesium-selective extractant based on dibenzo 18-crown-6. The process offers several potential advantages over possible alternatives in a chemical processing scheme for high-level waste treatment. First, if the process is applied as the first step in chemical pretreatment, the radiation level for all subsequent processing steps (e.g., transuranic extraction/recovery, or TRUEX) will be significantly reduced. Thus, less costly shielding would be required. The second advantage of the Combined CSEX-SREX Process is that the recovered Cs-Sr fraction is non-transuranic, and therefore will decay to low-level waste after only a few hundred years. Finally, combining individual processes into a single process will reduce the amount of equipment required to pretreat the waste and therefore reduce the size and cost of the waste processing facility. In an ongoing collaboration with Lockheed Martin Idaho Technology Company (LMITCO), the authors have successfully tested various segments of the Advanced Integrated Solvent Extraction Systems. Eichrom Industries, Inc. (Darien, IL) synthesizes and markets the Sr extractant and can supply the Cs extractant on a limited basis. Plans are under way to perform a test of the Combined CSEX-SREX Process with real waste at LMITCO in the near future.

  1. Sensorimotor Integration by Corticospinal System

    PubMed Central

    Moreno-López, Yunuen; Olivares-Moreno, Rafael; Cordero-Erausquin, Matilde; Rojas-Piloni, Gerardo

    2016-01-01

    The corticospinal (CS) tract is a complex system which targets several areas of the spinal cord. In particular, the CS descending projection plays a major role in motor command, which results from direct and indirect control of spinal cord pre-motor interneurons as well as motoneurons. But in addition, this system is also involved in a selective and complex modulation of sensory feedback. Despite recent evidence confirms that CS projections drive distinct segmental neural circuits that are part of the sensory and pre-motor pathways, little is known about the spinal networks engaged by the corticospinal tract (CST), the organization of CS projections, the intracortical microcircuitry, and the synaptic interactions in the sensorimotor cortex (SMC) that may encode different cortical outputs to the spinal cord. Here is stressed the importance of integrated approaches for the study of sensorimotor function of CS system, in order to understand the functional compartmentalization and hierarchical organization of layer 5 output neurons, who are key elements for motor control and hence, of behavior. PMID:27013985

  2. Preventing Integrator Windup In A Control System

    NASA Technical Reports Server (NTRS)

    Kaminer, Isaac

    1992-01-01

    Design concept for control system addresses how to prevent control inputs to plant from exceeding electrical limits imposed by mechanical limits of control actuators in plant, and prevent windup in integrators in control system. Concept consists of two parts. First, to rearrange terms of control equation to move integrators into output path of control system. Second, involves limiting inputs to integrators when one control input of plant reaches its limit. Concept applicable to control systems typical of aircraft autopilot systems.

  3. Human eye color difference threshold measurement system

    NASA Astrophysics Data System (ADS)

    Liu, Lin; Zhou, Taogeng

    2013-12-01

    The human eye has the ability to distinguish millions of colors, with this feature we can identify very subtle color differences, and the measurement of human eye color difference threshold can provide a visual function diagnosis for testee. In recent years, people begin to focus on studies on visual threshold diagnostic equipment. This paper proposes a human eye color difference threshold measurement system which is based on dual integrating sphere. The system includes two pairs of dual integrating sphere and color control module. Dual integrating sphere uses to mix and produce color, and palette unit which produces primary colors (red (R), green (G), blue (B)) is embedded in dual integrating sphere. At the same time, the embedded palette unit which produces cyan (C), magenta (M), and yellow (Y) expands color area that the system can generate. One optical path based on dual integrating sphere generates standard color, the other path produces the matching color which is similar to a standard color. In the high-precision closed-loop color control module, photoelectric switch records stepper motor's origin position and limits move displacement. Precision stepper motor pushes the light-blocking panel of the palette unit to a predetermined position, while real-time monitoring the position of the light-blocking panel and mixing the ideal controllable color. Two colors that the system generates are projected onto the same target area. Subjects make a judgment on color difference threshold by observing the target eventually.

  4. "Slimplectic" Integrators: Variational Integrators for General Nonconservative Systems

    NASA Astrophysics Data System (ADS)

    Tsang, David; Galley, Chad R.; Stein, Leo C.; Turner, Alec

    2015-08-01

    Symplectic integrators are widely used for long-term integration of conservative astrophysical problems due to their ability to preserve the constants of motion; however, they cannot in general be applied in the presence of nonconservative interactions. In this Letter, we develop the “slimplectic” integrator, a new type of numerical integrator that shares many of the benefits of traditional symplectic integrators yet is applicable to general nonconservative systems. We utilize a fixed-time-step variational integrator formalism applied to the principle of stationary nonconservative action developed in Galley et al. As a result, the generalized momenta and energy (Noether current) evolutions are well-tracked. We discuss several example systems, including damped harmonic oscillators, Poynting–Robertson drag, and gravitational radiation reaction, by utilizing our new publicly available code to demonstrate the slimplectic integrator algorithm. Slimplectic integrators are well-suited for integrations of systems where nonconservative effects play an important role in the long-term dynamical evolution. As such they are particularly appropriate for cosmological or celestial N-body dynamics problems where nonconservative interactions, e.g., gas interactions or dissipative tides, can play an important role.

  5. Systems integration of innate and adaptive immunity.

    PubMed

    Zak, Daniel E; Aderem, Alan

    2015-09-29

    The pathogens causing AIDS, malaria, and tuberculosis have proven too complex to be overcome by classical approaches to vaccination. The complexities of human immunology and pathogen-induced modulation of the immune system mandate new approaches to vaccine discovery and design. A new field, systems vaccinology, weds holistic analysis of innate and adaptive immunity within a quantitative framework to enable rational design of new vaccines that elicit tailored protective immune responses. A key step in the approach is to discover relationships between the earliest innate inflammatory responses to vaccination and the subsequent vaccine-induced adaptive immune responses and efficacy. Analysis of these responses in clinical studies is complicated by the inaccessibility of relevant tissue compartments (such as the lymph node), necessitating reliance upon peripheral blood responses as surrogates. Blood transcriptomes, although indirect to vaccine mechanisms, have proven very informative in systems vaccinology studies. The approach is most powerful when innate and adaptive immune responses are integrated with vaccine efficacy, which is possible for malaria with the advent of a robust human challenge model. This is more difficult for AIDS and tuberculosis, given that human challenge models are lacking and efficacy observed in clinical trials has been low or highly variable. This challenge can be met by appropriate clinical trial design for partially efficacious vaccines and by analysis of natural infection cohorts. Ultimately, systems vaccinology is an iterative approach in which mechanistic hypotheses-derived from analysis of clinical studies-are evaluated in model systems, and then used to guide the development of new vaccine strategies. In this review, we will illustrate the above facets of the systems vaccinology approach with case studies. PMID:26102534

  6. Systems Engineering and Integration for Advanced Life Support System and HST

    NASA Technical Reports Server (NTRS)

    Kamarani, Ali K.

    2005-01-01

    Systems engineering (SE) discipline has revolutionized the way engineers and managers think about solving issues related to design of complex systems: With continued development of state-of-the-art technologies, systems are becoming more complex and therefore, a systematic approach is essential to control and manage their integrated design and development. This complexity is driven from integration issues. In this case, subsystems must interact with one another in order to achieve integration objectives, and also achieve the overall system's required performance. Systems engineering process addresses these issues at multiple levels. It is a technology and management process dedicated to controlling all aspects of system life cycle to assure integration at all levels. The Advanced Integration Matrix (AIM) project serves as the systems engineering and integration function for the Human Support Technology (HST) program. AIM provides means for integrated test facilities and personnel for performance trade studies, analyses, integrated models, test results, and validated requirements of the integration of HST. The goal of AIM is to address systems-level integration issues for exploration missions. It will use an incremental systems integration approach to yield technologies, baselines for further development, and possible breakthrough concepts in the areas of technological and organizational interfaces, total information flow, system wide controls, technical synergism, mission operations protocols and procedures, and human-machine interfaces.

  7. Developing Metrics in Systems Integration (ISS Program COTS Integration Model)

    NASA Technical Reports Server (NTRS)

    Lueders, Kathryn

    2007-01-01

    This viewgraph presentation reviews some of the complications in developing metrics for systems integration. Specifically it reviews a case study of how two programs within NASA try to develop and measure performance while meeting the encompassing organizational goals.

  8. Assuring structural integrity in Army systems

    NASA Technical Reports Server (NTRS)

    1985-01-01

    The object of this study was to recommend possible improvements in the manner in which structural integrity of Army systems is assured. The elements of a structural integrity program are described, and relevant practices used in various industries and government organizations are reviewed. Some case histories of Army weapon systems are examined. The mandatory imposition of a structural integrity program patterned after the Air Force Aircraft Structural Integrity Program is recommended and the benefits of such an action are identified.

  9. Power Systems Integration Laboratory (Fact Sheet)

    SciTech Connect

    Not Available

    2011-10-01

    This fact sheet describes the purpose, lab specifications, applications scenarios, and information on how to partner with NREL's Power Systems Integration Laboratory at the Energy Systems Integration Facility. At NREL's Power Systems Integration Laboratory in the Energy Systems Integration Facility (ESIF), research focuses on developing and testing large-scale distributed energy systems for grid-connected, stand-alone, and microgrid applications. The laboratory can accommodate large power system components such as inverters for photovoltaic (PV) and wind systems, diesel and natural gas generators, battery packs, microgrid interconnection switchgear, and vehicles. Closely coupled with the research electrical distribution bus at the ESIF, the Power Systems Integration Laboratory will offer power testing capability of megawatt-scale DC and AC power systems, as well as advanced hardware-in-the-loop and model-in-the-loop simulation capabilities. Thermal heating and cooling loops and fuel also allow testing of combined heating/cooling and power systems (CHP).

  10. System integration of pattern recognition, adaptive aided, upper limb prostheses

    NASA Technical Reports Server (NTRS)

    Lyman, J.; Freedy, A.; Solomonow, M.

    1975-01-01

    The requirements for successful integration of a computer aided control system for multi degree of freedom artificial arms are discussed. Specifications are established for a system which shares control between a human amputee and an automatic control subsystem. The approach integrates the following subsystems: (1) myoelectric pattern recognition, (2) adaptive computer aiding; (3) local reflex control; (4) prosthetic sensory feedback; and (5) externally energized arm with the functions of prehension, wrist rotation, elbow extension and flexion and humeral rotation.

  11. Decentralized Multisensory Information Integration in Neural Systems

    PubMed Central

    Zhang, Wen-hao; Chen, Aihua

    2016-01-01

    How multiple sensory cues are integrated in neural circuitry remains a challenge. The common hypothesis is that information integration might be accomplished in a dedicated multisensory integration area receiving feedforward inputs from the modalities. However, recent experimental evidence suggests that it is not a single multisensory brain area, but rather many multisensory brain areas that are simultaneously involved in the integration of information. Why many mutually connected areas should be needed for information integration is puzzling. Here, we investigated theoretically how information integration could be achieved in a distributed fashion within a network of interconnected multisensory areas. Using biologically realistic neural network models, we developed a decentralized information integration system that comprises multiple interconnected integration areas. Studying an example of combining visual and vestibular cues to infer heading direction, we show that such a decentralized system is in good agreement with anatomical evidence and experimental observations. In particular, we show that this decentralized system can integrate information optimally. The decentralized system predicts that optimally integrated information should emerge locally from the dynamics of the communication between brain areas and sheds new light on the interpretation of the connectivity between multisensory brain areas. SIGNIFICANCE STATEMENT To extract information reliably from ambiguous environments, the brain integrates multiple sensory cues, which provide different aspects of information about the same entity of interest. Here, we propose a decentralized architecture for multisensory integration. In such a system, no processor is in the center of the network topology and information integration is achieved in a distributed manner through reciprocally connected local processors. Through studying the inference of heading direction with visual and vestibular cues, we show that

  12. Health systems, communicable diseases and integration.

    PubMed

    Shigayeva, Altynay; Atun, Rifat; McKee, Martin; Coker, Richard

    2010-11-01

    The HIV/AIDS, tuberculosis and malaria pandemics pose substantial challenges globally and to health systems in the countries they affect. This demands an institutional approach that can integrate disease control programmes within health and social care systems. Whilst integration is intuitively appealing, evidence of its benefits remains uncertain and evaluation is beset by lack of a common understanding of what it involves. The aim of this paper is to better define integration in health systems relevant to communicable disease control. We conducted a critical review of published literature on concepts, definitions, and analytical and methodological approaches to integration as applied to health system responses to communicable disease. We found that integration is understood and pursued in many ways in different health systems. We identified a variety of typologies that relate to three fundamental questions associated with integration: (1) why is integration a goal (that is, what are the driving forces for integration); (2) what structures and/or functions at different levels of health system are affected by integration (or the lack of); and (3) how does integration influence interactions between health system components or stakeholders. The frameworks identified were evaluated in terms of these questions, as well as the extent to which they took account of health system characteristics, the wider contextual environment in which health systems sit, and the roles of key stakeholders. We did not find any one framework that explicitly addressed all of these three questions and therefore propose an analytical framework to help address these questions, building upon existing frameworks and extending our conceptualization of the 'how' of integration to identify a continuum of interactions that extends from no interactions, to partial integration that includes linkage and coordination, and ultimately to integration. We hope that our framework may provide a basis for

  13. Integrated analysis environment for high impact systems

    SciTech Connect

    Martinez, M.; Davis, J.; Scott, J.; Sztipanovits, J.; Karsai, G.

    1998-02-01

    Modeling and analysis of high consequence, high assurance systems requires special modeling considerations. System safety and reliability information must be captured in the models. Previously, high consequence systems were modeled using separate, disjoint models for safety, reliability, and security. The MultiGraph Architecture facilitates the implementation of a model integrated system for modeling and analysis of high assurance systems. Model integrated computing allows an integrated modeling technique to be applied to high consequence systems. Among the tools used for analyzing safety and reliability are a behavioral simulator and an automatic fault tree generation and analysis tool. Symbolic model checking techniques are used to efficiently investigate the system models. A method for converting finite state machine models to ordered binary decision diagrams allows the application of symbolic model checking routines to the integrated system models. This integrated approach to modeling and analysis of high consequence systems ensures consistency between the models and the different analysis tools.

  14. Integrated System for Autonomous Science

    NASA Technical Reports Server (NTRS)

    Chien, Steve; Sherwood, Robert; Tran, Daniel; Cichy, Benjamin; Davies, Ashley; Castano, Rebecca; Rabideau, Gregg; Frye, Stuart; Trout, Bruce; Shulman, Seth; Doggett, Thomas; Ip, Felipe; Greeley, Ron; Baker, Victor; Dohn, James; Boyer, Darrell

    2006-01-01

    The New Millennium Program Space Technology 6 Project Autonomous Sciencecraft software implements an integrated system for autonomous planning and execution of scientific, engineering, and spacecraft-coordination actions. A prior version of this software was reported in "The TechSat 21 Autonomous Sciencecraft Experiment" (NPO-30784), NASA Tech Briefs, Vol. 28, No. 3 (March 2004), page 33. This software is now in continuous use aboard the Earth Orbiter 1 (EO-1) spacecraft mission and is being adapted for use in the Mars Odyssey and Mars Exploration Rovers missions. This software enables EO-1 to detect and respond to such events of scientific interest as volcanic activity, flooding, and freezing and thawing of water. It uses classification algorithms to analyze imagery onboard to detect changes, including events of scientific interest. Detection of such events triggers acquisition of follow-up imagery. The mission-planning component of the software develops a response plan that accounts for visibility of targets and operational constraints. The plan is then executed under control by a task-execution component of the software that is capable of responding to anomalies.

  15. Wearable smart systems: from technologies to integrated systems.

    PubMed

    Lymberis, A

    2011-01-01

    Wearable technology and integrated systems, so called Smart Wearable Systems (SWS) have demonstrated during the last 10-15 years significant advances in terms of, miniaturisation, seamless integration, data processing & communication, functionalisation and comfort. This is mainly due to the huge progress in sciences and technologies e.g. biomedical and micro & nano technologies, but also to a strong demand for new applications such as continuous personal health monitoring, healthy lifestyle support, human performance monitoring and support of professionals at risk. Development of wearable systems based of smart textile have, in addition, benefited from the eagerness of textile industry to develop new value-added apparel products like functionalized garments and smart clothing. Research and development in these areas has been strongly promoted worldwide. In Europe the major R&D activities were supported through the Information & Communication Technologies (ICT) priority of the R&D EU programs. The paper presents and discusses the main achievements towards integrated systems as well as future challenges to be met in order to reach a market with reliable and high value-added products. PMID:22255095

  16. Support Systems for Treatment Integrity

    ERIC Educational Resources Information Center

    Goense, Pauline Brigitta; Boendermaker, Leonieke; van Yperen, Tom

    2016-01-01

    Objective: This systematic review evaluates the content of effective support provided to practitioners of evidence-based interventions in order to establish and maintain treatment integrity. Method: Four articles covering six outcome studies are included in this review, these studies (1) adequately operationalized treatment integrity procedures…

  17. Airborne laser sensors and integrated systems

    NASA Astrophysics Data System (ADS)

    Sabatini, Roberto; Richardson, Mark A.; Gardi, Alessandro; Ramasamy, Subramanian

    2015-11-01

    The underlying principles and technologies enabling the design and operation of airborne laser sensors are introduced and a detailed review of state-of-the-art avionic systems for civil and military applications is presented. Airborne lasers including Light Detection and Ranging (LIDAR), Laser Range Finders (LRF), and Laser Weapon Systems (LWS) are extensively used today and new promising technologies are being explored. Most laser systems are active devices that operate in a manner very similar to microwave radars but at much higher frequencies (e.g., LIDAR and LRF). Other devices (e.g., laser target designators and beam-riders) are used to precisely direct Laser Guided Weapons (LGW) against ground targets. The integration of both functions is often encountered in modern military avionics navigation-attack systems. The beneficial effects of airborne lasers including the use of smaller components and remarkable angular resolution have resulted in a host of manned and unmanned aircraft applications. On the other hand, laser sensors performance are much more sensitive to the vagaries of the atmosphere and are thus generally restricted to shorter ranges than microwave systems. Hence it is of paramount importance to analyse the performance of laser sensors and systems in various weather and environmental conditions. Additionally, it is important to define airborne laser safety criteria, since several systems currently in service operate in the near infrared with considerable risk for the naked human eye. Therefore, appropriate methods for predicting and evaluating the performance of infrared laser sensors/systems are presented, taking into account laser safety issues. For aircraft experimental activities with laser systems, it is essential to define test requirements taking into account the specific conditions for operational employment of the systems in the intended scenarios and to verify the performance in realistic environments at the test ranges. To support the

  18. INTEGRATED HYDROGEN STORAGE SYSTEM MODEL

    SciTech Connect

    Hardy, B

    2007-11-16

    Hydrogen storage is recognized as a key technical hurdle that must be overcome for the realization of hydrogen powered vehicles. Metal hydrides and their doped variants have shown great promise as a storage material and significant advances have been made with this technology. In any practical storage system the rate of H2 uptake will be governed by all processes that affect the rate of mass transport through the bed and into the particles. These coupled processes include heat and mass transfer as well as chemical kinetics and equilibrium. However, with few exceptions, studies of metal hydrides have focused primarily on fundamental properties associated with hydrogen storage capacity and kinetics. A full understanding of the complex interplay of physical processes that occur during the charging and discharging of a practical storage system requires models that integrate the salient phenomena. For example, in the case of sodium alanate, the size of NaAlH4 crystals is on the order of 300nm and the size of polycrystalline particles may be approximately 10 times larger ({approx}3,000nm). For the bed volume to be as small as possible, it is necessary to densely pack the hydride particles. Even so, in packed beds composed of NaAlH{sub 4} particles alone, it has been observed that the void fraction is still approximately 50-60%. Because of the large void fraction and particle to particle thermal contact resistance, the thermal conductivity of the hydride is very low, on the order of 0.2 W/m-{sup o}C, Gross, Majzoub, Thomas and Sandrock [2002]. The chemical reaction for hydrogen loading is exothermic. Based on the data in Gross [2003], on the order of 10{sup 8}J of heat of is released for the uptake of 5 kg of H{sub 2}2 and complete conversion of NaH to NaAlH{sub 4}. Since the hydride reaction transitions from hydrogen loading to discharge at elevated temperatures, it is essential to control the temperature of the bed. However, the low thermal conductivity of the hydride

  19. Integrative analysis of 111 reference human epigenomes

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The reference human genome sequence set the stage for studies of genetic variation and its association with human disease, but epigenomic studies lack a similar reference. To address this need, the NIH Roadmap Epigenomics Consortium generated the largest collection so far of human epigenomes for pri...

  20. Feedbacks in human-landscape systems

    NASA Astrophysics Data System (ADS)

    Chin, Anne

    2015-04-01

    As human interactions with Earth systems intensify in the "Anthropocene", understanding the complex relationships among human activity, landscape change, and societal responses to those changes is increasingly important. Interdisciplinary research centered on the theme of "feedbacks" in human-landscape systems serves as a promising focus for unraveling these interactions. Deciphering interacting human-landscape feedbacks extends our traditional approach of considering humans as unidirectional drivers of change. Enormous challenges exist, however, in quantifying impact-feedback loops in landscapes with significant human alterations. This paper illustrates an example of human-landscape interactions following a wildfire in Colorado (USA) that elicited feedback responses. After the 2012 Waldo Canyon Fire, concerns for heightened flood potential and debris flows associated with post-fire hydrologic changes prompted local landowners to construct tall fences at the base of a burned watershed. These actions changed the sediment transport regime and promoted further landscape change and human responses in a positive feedback cycle. The interactions ultimately increase flood and sediment hazards, rather than dampening the effects of fire. A simple agent-based model, capable of integrating social and hydro-geomorphological data, demonstrates how such interacting impacts and feedbacks could be simulated. Challenges for fully capturing human-landscape feedback interactions include the identification of diffuse and subtle feedbacks at a range of scales, the availability of data linking impact with response, the identification of multiple thresholds that trigger feedback mechanisms, and the varied metrics and data needed to represent both the physical and human systems. By collaborating with social scientists with expertise in the human causes of landscape change, as well as the human responses to those changes, geoscientists could more fully recognize and anticipate the coupled

  1. Integrated Public Education, Fertility and Human Capital

    ERIC Educational Resources Information Center

    Azarnert, Leonid V.

    2014-01-01

    This paper analyzes the consequences of integration in public education. I show that the flight from the integrated multicultural public schools to private education increases private educational expenditures and, as a result, decreases fertility among more affluent parents whose children flee. In contrast, among less prosperous parents…

  2. Context in Models of Human-Machine Systems

    NASA Technical Reports Server (NTRS)

    Callantine, Todd J.; Null, Cynthia H. (Technical Monitor)

    1998-01-01

    All human-machine systems models represent context. This paper proposes a theory of context through which models may be usefully related and integrated for design. The paper presents examples of context representation in various models, describes an application to developing models for the Crew Activity Tracking System (CATS), and advances context as a foundation for integrated design of complex dynamic systems.

  3. CLARA: an integrated clinical research administration system.

    PubMed

    Bian, Jiang; Xie, Mengjun; Hogan, William; Hutchins, Laura; Topaloglu, Umit; Lane, Cheryl; Holland, Jennifer; Wells, Thomas

    2014-10-01

    Administration of human subject research is complex, involving not only the institutional review board but also many other regulatory and compliance entities within a research enterprise. Its efficiency has a direct and substantial impact on the conduct and management of clinical research. In this paper, we report on the Clinical Research Administration (CLARA) platform developed at the University of Arkansas for Medical Sciences. CLARA is a comprehensive web-based system that can streamline research administrative tasks such as submissions, reviews, and approval processes for both investigators and different review committees on a single integrated platform. CLARA not only helps investigators to meet regulatory requirements but also provides tools for managing other clinical research activities including budgeting, contracting, and participant schedule planning. PMID:24778201

  4. Integrated Modular Teaching of Human Biology for Primary Care Practitioners

    ERIC Educational Resources Information Center

    Glasgow, Michael S.

    1977-01-01

    Describes the use of integrated modular teaching of the human biology component of the Health Associate Program at Johns Hopkins University, where the goal is to develop an understanding of the sciences as applied to primary care. Discussion covers the module sequence, the human biology faculty, goals of the human biology faculty, laboratory…

  5. Integrating the Humanities and Business Education in Community Colleges.

    ERIC Educational Resources Information Center

    Monnin, Lloyd N.

    This three-part address comments upon the place of the humanities in the community college curriculum, summarizes the content of a summer institute sponsored by the Community College Humanities Association (CCHA), and considers the integration of the humanities and business education in community colleges. In the first section, comments by CCHA's…

  6. Integrated Computer System of Management in Logistics

    NASA Astrophysics Data System (ADS)

    Chwesiuk, Krzysztof

    2011-06-01

    This paper aims at presenting a concept of an integrated computer system of management in logistics, particularly in supply and distribution chains. Consequently, the paper includes the basic idea of the concept of computer-based management in logistics and components of the system, such as CAM and CIM systems in production processes, and management systems for storage, materials flow, and for managing transport, forwarding and logistics companies. The platform which integrates computer-aided management systems is that of electronic data interchange.

  7. The Integrated Space Weather Analysis System

    NASA Astrophysics Data System (ADS)

    Maddox, M. M.; Hesse, M.; Kuznetsova, M.; Rastaetter, L.; MacNeice, P. J.; Jain, P.; Garneau, J. W.; Berrios, D. H.; Pulkinnen, A.; Rowland, D.

    2008-12-01

    Space weather affects virtually all of NASA's endeavors, from robotic missions to human exploration. Knowledge and prediction of space weather conditions is therefore essential to NASA operations. The diverse nature of currently available space environment measurements and modeling products, along with the lack of single-portal access, renders its practical use for space weather analysis and forecasting unfeasible. There exists a compelling need for accurate real-time forecasting of both large-scale and local space environments - and their probable impacts for missions. A vital design driver for any system that is created to solve this problem lies in the fact that information needs to be presented in a form that is useful and as such, must be both easily accessible and understandable. The Integrated Space Weather Analysis System is a joint development project at NASA GSFC between the Space Weather Laboratory, Community Coordinated Modeling Center, Applied Engineering & Technology Directorate, and NASA HQ Office Of Chief Engineer. The iSWA system will be a turnkey, web-based dissemination system for NASA-relevant space weather information that combines forecasts based on the most advanced space weather models with concurrent space environment information. It will be customer configurable and adaptable for use as a powerful decision making tool offering an unprecedented ability to analyze the present and expected future space weather impacts on virtually all NASA human and robotic missions. We will discuss some of the key design considerations for the system and present some of the initial space weather analysis products that have been created to date.

  8. Disorder in Complex Human System

    NASA Astrophysics Data System (ADS)

    Akdeniz, K. Gediz

    2011-11-01

    Since the world of human and whose life becomes more and more complex every day because of the digital technology and under the storm of knowledge (media, internet, governmental and non-governmental organizations, etc...) the simulation is rapidly growing in the social systems and in human behaviors. The formation of the body and mutual interactions are left to digital technological, communication mechanisms and coding the techno genetics of the body. Deconstruction begins everywhere. The linear simulation mechanism with modern realities are replaced by the disorder simulation of human behaviors with awareness realities. In this paper I would like to introduce simulation theory of "Disorder Sensitive Human Behaviors". I recently proposed this theory to critique the role of disorder human behaviors in social systems. In this theory the principle of realty is the chaotic awareness of the complexity of human systems inside of principle of modern thinking in Baudrillard's simulation theory. Proper examples will be also considered to investigate the theory.

  9. NASA Human System Risk Assessment Process

    NASA Technical Reports Server (NTRS)

    Francisco, D.; Romero, E.

    2016-01-01

    NASA utilizes an evidence based system to perform risk assessments for the human system for spaceflight missions. The center of this process is the multi-disciplinary Human System Risk Board (HSRB). The HSRB is chartered from the Chief Health and Medical Officer (OCHMO) at NASA Headquarters. The HSRB reviews all human system risks via an established comprehensive risk and configuration management plan based on a project management approach. The HSRB facilitates the integration of human research (terrestrial and spaceflight), medical operations, occupational surveillance, systems engineering and many other disciplines in a comprehensive review of human system risks. The HSRB considers all factors that influence human risk. These factors include pre-mission considerations such as screening criteria, training, age, sex, and physiological condition. In mission factors such as available countermeasures, mission duration and location and post mission factors such as time to return to baseline (reconditioning), post mission health screening, and available treatments. All of the factors influence the total risk assessment for each human risk. The HSRB performed a comprehensive review of all potential inflight medical conditions and events and over the course of several reviews consolidated the number of human system risks to 30, where the greatest emphasis is placed for investing program dollars for risk mitigation. The HSRB considers all available evidence from human research and, medical operations and occupational surveillance in assessing the risks for appropriate mitigation and future work. All applicable DRMs (low earth orbit for 6 and 12 months, deep space for 30 days and 1 year, a lunar mission for 1 year, and a planetary mission for 3 years) are considered as human system risks are modified by the hazards associated with space flight such as microgravity, exposure to radiation, distance from the earth, isolation and a closed environment. Each risk has a summary

  10. Integrated Procurement Management System, Version II

    NASA Technical Reports Server (NTRS)

    Collier, L. J.

    1985-01-01

    Integrated Procurement Management System, Version II (IPMS II) is online/ batch system for collecting developing, managing and disseminating procurementrelated data at NASA Johnson Space Center. Portions of IPMS II adaptable to other procurement situations.

  11. An Integrated Framework for Human-Robot Collaborative Manipulation.

    PubMed

    Sheng, Weihua; Thobbi, Anand; Gu, Ye

    2015-10-01

    This paper presents an integrated learning framework that enables humanoid robots to perform human-robot collaborative manipulation tasks. Specifically, a table-lifting task performed jointly by a human and a humanoid robot is chosen for validation purpose. The proposed framework is split into two phases: 1) phase I-learning to grasp the table and 2) phase II-learning to perform the manipulation task. An imitation learning approach is proposed for phase I. In phase II, the behavior of the robot is controlled by a combination of two types of controllers: 1) reactive and 2) proactive. The reactive controller lets the robot take a reactive control action to make the table horizontal. The proactive controller lets the robot take proactive actions based on human motion prediction. A measure of confidence of the prediction is also generated by the motion predictor. This confidence measure determines the leader/follower behavior of the robot. Hence, the robot can autonomously switch between the behaviors during the task. Finally, the performance of the human-robot team carrying out the collaborative manipulation task is experimentally evaluated on a platform consisting of a Nao humanoid robot and a Vicon motion capture system. Results show that the proposed framework can enable the robot to carry out the collaborative manipulation task successfully. PMID:25373136

  12. Data Integration in Computer Distributed Systems

    NASA Astrophysics Data System (ADS)

    Kwiecień, Błażej

    In this article the author analyze a problem of data integration in a computer distributed systems. Exchange of information between different levels in integrated pyramid of enterprise process is fundamental with regard to efficient enterprise work. Communication and data exchange between levels are not always the same cause of necessity of different network protocols usage, communication medium, system response time, etc.

  13. Vector Product and an Integrable Dynamical System

    NASA Astrophysics Data System (ADS)

    Willi-Hans, Steeb; Yorick, Hardy; Igor, Tanski

    2011-12-01

    We study an autonomous system of first order ordinary differential equations based on the vector product. We show that the system is completely integrable by constructing the first integrals. The connection with Nambu mechanics is established. The extension to higher dimensions is also discussed.

  14. An Integrated Library System: Preliminary Considerations.

    ERIC Educational Resources Information Center

    Neroda, Edward

    Noting difficulties experienced by small to medium sized colleges in acquiring integrated library computer systems, this position paper outlines issues related to the subject with the intention of increasing familiarity and interest in integrated library systems. The report includes: a brief review of technological advances as they relate to…

  15. Integrative regulation of human brain blood flow

    PubMed Central

    Willie, Christopher K; Tzeng, Yu-Chieh; Fisher, Joseph A; Ainslie, Philip N

    2014-01-01

    Herein, we review mechanisms regulating cerebral blood flow (CBF), with specific focus on humans. We revisit important concepts from the older literature and describe the interaction of various mechanisms of cerebrovascular control. We amalgamate this broad scope of information into a brief review, rather than detailing any one mechanism or area of research. The relationship between regulatory mechanisms is emphasized, but the following three broad categories of control are explicated: (1) the effect of blood gases and neuronal metabolism on CBF; (2) buffering of CBF with changes in blood pressure, termed cerebral autoregulation; and (3) the role of the autonomic nervous system in CBF regulation. With respect to these control mechanisms, we provide evidence against several canonized paradigms of CBF control. Specifically, we corroborate the following four key theses: (1) that cerebral autoregulation does not maintain constant perfusion through a mean arterial pressure range of 60–150 mmHg; (2) that there is important stimulatory synergism and regulatory interdependence of arterial blood gases and blood pressure on CBF regulation; (3) that cerebral autoregulation and cerebrovascular sensitivity to changes in arterial blood gases are not modulated solely at the pial arterioles; and (4) that neurogenic control of the cerebral vasculature is an important player in autoregulatory function and, crucially, acts to buffer surges in perfusion pressure. Finally, we summarize the state of our knowledge with respect to these areas, outline important gaps in the literature and suggest avenues for future research. PMID:24396059

  16. Integrative regulation of human brain blood flow.

    PubMed

    Willie, Christopher K; Tzeng, Yu-Chieh; Fisher, Joseph A; Ainslie, Philip N

    2014-03-01

    Herein, we review mechanisms regulating cerebral blood flow (CBF), with specific focus on humans. We revisit important concepts from the older literature and describe the interaction of various mechanisms of cerebrovascular control. We amalgamate this broad scope of information into a brief review, rather than detailing any one mechanism or area of research. The relationship between regulatory mechanisms is emphasized, but the following three broad categories of control are explicated: (1) the effect of blood gases and neuronal metabolism on CBF; (2) buffering of CBF with changes in blood pressure, termed cerebral autoregulation; and (3) the role of the autonomic nervous system in CBF regulation. With respect to these control mechanisms, we provide evidence against several canonized paradigms of CBF control. Specifically, we corroborate the following four key theses: (1) that cerebral autoregulation does not maintain constant perfusion through a mean arterial pressure range of 60-150 mmHg; (2) that there is important stimulatory synergism and regulatory interdependence of arterial blood gases and blood pressure on CBF regulation; (3) that cerebral autoregulation and cerebrovascular sensitivity to changes in arterial blood gases are not modulated solely at the pial arterioles; and (4) that neurogenic control of the cerebral vasculature is an important player in autoregulatory function and, crucially, acts to buffer surges in perfusion pressure. Finally, we summarize the state of our knowledge with respect to these areas, outline important gaps in the literature and suggest avenues for future research. PMID:24396059

  17. ISSYS: An integrated synergistic Synthesis System

    NASA Technical Reports Server (NTRS)

    Dovi, A. R.

    1980-01-01

    Integrated Synergistic Synthesis System (ISSYS), an integrated system of computer codes in which the sequence of program execution and data flow is controlled by the user, is discussed. The commands available to exert such control, the ISSYS major function and rules, and the computer codes currently available in the system are described. Computational sequences frequently used in the aircraft structural analysis and synthesis are defined. External computer codes utilized by the ISSYS system are documented. A bibliography on the programs is included.

  18. An Integrated Hybrid Transportation Architecture for Human Mars Expeditions

    NASA Technical Reports Server (NTRS)

    Merrill, Raymond G.; Chai, Patrick R.; Qu, Min

    2015-01-01

    NASA's Human Spaceflight Architecture Team is developing a reusable hybrid transportation architecture that uses both chemical and electric propulsion systems on the same vehicle to send crew and cargo to Mars destinations such as Phobos, Deimos, the surface of Mars, and other orbits around Mars. By applying chemical and electrical propulsion where each is most effective, the hybrid architecture enables a series of Mars trajectories that are more fuel-efficient than an all chemical architecture without significant increases in flight times. This paper presents an integrated Hybrid in-space transportation architecture for piloted missions and delivery of cargo. A concept for a Mars campaign including orbital and Mars surface missions is described in detail including a system concept of operations and conceptual design. Specific constraints, margin, and pinch points are identified for the architecture and opportunities for critical path commercial and international collaboration are discussed.

  19. Integrating human stem cell expansion and neuronal differentiation in bioreactors

    PubMed Central

    Serra, Margarida; Brito, Catarina; Costa, Eunice M; Sousa, Marcos FQ; Alves, Paula M

    2009-01-01

    Background Human stem cells are cellular resources with outstanding potential for cell therapy. However, for the fulfillment of this application, major challenges remain to be met. Of paramount importance is the development of robust systems for in vitro stem cell expansion and differentiation. In this work, we successfully developed an efficient scalable bioprocess for the fast production of human neurons. Results The expansion of undifferentiated human embryonal carcinoma stem cells (NTera2/cl.D1 cell line) as 3D-aggregates was firstly optimized in spinner vessel. The media exchange operation mode with an inoculum concentration of 4 × 105 cell/mL was the most efficient strategy tested, with a 4.6-fold increase in cell concentration achieved in 5 days. These results were validated in a bioreactor where similar profile and metabolic performance were obtained. Furthermore, characterization of the expanded population by immunofluorescence microscopy and flow cytometry showed that NT2 cells maintained their stem cell characteristics along the bioreactor culture time. Finally, the neuronal differentiation step was integrated in the bioreactor process, by addition of retinoic acid when cells were in the middle of the exponential phase. Neurosphere composition was monitored and neuronal differentiation efficiency evaluated along the culture time. The results show that, for bioreactor cultures, we were able to increase significantly the neuronal differentiation efficiency by 10-fold while reducing drastically, by 30%, the time required for the differentiation process. Conclusion The culture systems developed herein are robust and represent one-step-forward towards the development of integrated bioprocesses, bridging stem cell expansion and differentiation in fully controlled bioreactors. PMID:19772662

  20. Integration Testing of Space Flight Systems

    NASA Technical Reports Server (NTRS)

    Honeycutt, Timothy; Sowards, Stephanie

    2008-01-01

    Based on the previous success' of Multi-Element Integration Testing (MEITs) for the International Space Station Program, these type of integrated tests have also been planned for the Constellation Program: MEIT (1) CEV to ISS (emulated) (2) CEV to Lunar Lander/EDS (emulated) (3) Future: Lunar Surface Systems and Mars Missions Finite Element Integration Test (FEIT) (1) CEV/CLV (2) Lunar Lander/EDS/CaL V Integrated Verification Tests (IVT) (1) Performed as a subset of the FEITs during the flight tests and then performed for every flight after Full Operational Capability (FOC) has been obtained with the flight and ground Systems.

  1. Open architecture in control system integration

    SciTech Connect

    Wysor, R.W.; Carnal, C.L.; Igou, R.E.

    1993-09-01

    Open architecture offers the manufacturing community a number of advantages in the integration of future machine control systems. Among these advantages is the ability to upgrade and take advantage of innovative new control strategies. A key enabling technology in open architecture control systems is the digital signal processor (DSP). DSPs can be used to provide a complete control system or can enhance the computational capability of larger control systems. The use of DSPs in the integration of open architecture control systems is discussed, including their impact on reliability and control system functionality. In addition, the role of DSPs in control system architecture is addressed.

  2. Human Frontal Lobes and AI Planning Systems

    NASA Technical Reports Server (NTRS)

    Levinson, Richard; Lum, Henry Jr. (Technical Monitor)

    1994-01-01

    Human frontal lobes are essential for maintaining a self-regulating balance between predictive and reactive behavior. This paper describes a system that integrates prediction and reaction based on neuropsychological theories of frontal lobe function. In addition to enhancing our understanding of deliberate action in humans' the model is being used to develop and evaluate the same properties in machines. First, the paper presents some background neuropsychology in order to set a general context. The role of frontal lobes is then presented by summarizing three theories which formed the basis for this work. The components of an artificial frontal lobe are then discussed from both neuropsychological and AI perspectives. The paper concludes by discussing issues and methods for evaluating systems that integrate planning and reaction.

  3. Human Error In Complex Systems

    NASA Technical Reports Server (NTRS)

    Morris, Nancy M.; Rouse, William B.

    1991-01-01

    Report presents results of research aimed at understanding causes of human error in such complex systems as aircraft, nuclear powerplants, and chemical processing plants. Research considered both slips (errors of action) and mistakes (errors of intention), and influence of workload on them. Results indicated that: humans respond to conditions in which errors expected by attempting to reduce incidence of errors; and adaptation to conditions potent influence on human behavior in discretionary situations.

  4. Integrating IR detector imaging systems

    NASA Technical Reports Server (NTRS)

    Bailey, G. C. (Inventor)

    1984-01-01

    An integrating IR detector array for imaging is provided in a hybrid circuit with InSb mesa diodes in a linear array, a single J-FET preamplifier for readout, and a silicon integrated circuit multiplexer. Thin film conductors in a fan out pattern deposited on an Al2O3 substrate connect the diodes to the multiplexer, and thick film conductors also connect the reset switch and preamplifier to the multiplexer. Two phase clock pulses are applied with a logic return signal to the multiplexer through triax comprised of three thin film conductors deposited between layers. A lens focuses a scanned image onto the diode array for horizontal read out while a scanning mirror provides vertical scan.

  5. SUBSURFACE REPOSITORY INTEGRATED CONTROL SYSTEM DESIGN

    SciTech Connect

    C.J. Fernado

    1998-09-17

    The purpose of this document is to develop preliminary high-level functional and physical control system architectures for the proposed subsurface repository at Yucca Mountain. This document outlines overall control system concepts that encompass and integrate the many diverse systems being considered for use within the subsurface repository. This document presents integrated design concepts for monitoring and controlling the diverse set of subsurface operations. The subsurface repository design will be composed of a series of diverse systems that will be integrated to accomplish a set of overall functions and objectives. The subsurface repository contains several Instrumentation and Control (I&C) related systems including: waste emplacement systems, ventilation systems, communication systems, radiation monitoring systems, rail transportation systems, ground control monitoring systems, utility monitoring systems (electrical, lighting, water, compressed air, etc.), fire detection and protection systems, retrieval systems, and performance confirmation systems. Each of these systems involve some level of I&C and will typically be integrated over a data communication network. The subsurface I&C systems will also integrate with multiple surface-based site-wide systems such as emergency response, health physics, security and safeguards, communications, utilities and others. The scope and primary objectives of this analysis are to: (1) Identify preliminary system level functions and interface needs (Presented in the functional diagrams in Section 7.2). (2) Examine the overall system complexity and determine how and on what levels these control systems will be controlled and integrated (Presented in Section 7.2). (3) Develop a preliminary subsurface facility-wide design for an overall control system architecture, and depict this design by a series of control system functional block diagrams (Presented in Section 7.2). (4) Develop a series of physical architectures that

  6. Guest editorial. Integrated healthcare information systems.

    PubMed

    Li, Ling; Ge, Ri-Li; Zhou, Shang-Ming; Valerdi, Ricardo

    2012-07-01

    The use of integrated information systems for healthcare has been started more than a decade ago. In recent years, rapid advances in information integration methods have spurred tremendous growth in the use of integrated information systems in healthcare delivery. Various techniques have been used for probing such integrated systems. These techniques include service-oriented architecture (SOA), EAI, workflow management, grid computing, and others. Many applications require a combination of these techniques, which gives rise to the emergence of enterprise systems in healthcare. Development of the techniques originated from different disciplines has the potential to significantly improve the performance of enterprise systems in healthcare. This editorial paper briefly introduces the enterprise systems in the perspective of healthcare informatics. PMID:22760931

  7. Health systems integration: state of the evidence

    PubMed Central

    Armitage, Gail D.; Suter, Esther; Oelke, Nelly D.; Adair, Carol E.

    2009-01-01

    Introduction Integrated health systems are considered a solution to the challenge of maintaining the accessibility and integrity of healthcare in numerous jurisdictions worldwide. However, decision makers in a Canadian health region indicated they were challenged to find evidence-based information to assist with the planning and implementation of integrated healthcare systems. Methods A systematic literature review of peer-reviewed literature from health sciences and business databases, and targeted grey literature sources. Results Despite the large number of articles discussing integration, significant gaps in the research literature exist. There was a lack of high quality, empirical studies providing evidence on how health systems can improve service delivery and population health. No universal definition or concept of integration was found and multiple integration models from both the healthcare and business literature were proposed in the literature. The review also revealed a lack of standardized, validated tools that have been systematically used to evaluate integration outcomes. This makes measuring and comparing the impact of integration on system, provider and patient level challenging. Discussion and conclusion Healthcare is likely too complex for a one-size-fits-all integration solution. It is important for decision makers and planners to choose a set of complementary models, structures and processes to create an integrated health system that fits the needs of the population across the continuum of care. However, in order to have evidence available, decision makers and planners should include evaluation for accountability purposes and to ensure a better understanding of the effectiveness and impact of health systems integration. PMID:19590762

  8. The integrated Earth system model version 1: formulation and functionality

    NASA Astrophysics Data System (ADS)

    Collins, W. D.; Craig, A. P.; Truesdale, J. E.; Di Vittorio, A. V.; Jones, A. D.; Bond-Lamberty, B.; Calvin, K. V.; Edmonds, J. A.; Kim, S. H.; Thomson, A. M.; Patel, P.; Zhou, Y.; Mao, J.; Shi, X.; Thornton, P. E.; Chini, L. P.; Hurtt, G. C.

    2015-07-01

    The integrated Earth system model (iESM) has been developed as a new tool for projecting the joint human/climate system. The iESM is based upon coupling an integrated assessment model (IAM) and an Earth system model (ESM) into a common modeling infrastructure. IAMs are the primary tool for describing the human-Earth system, including the sources of global greenhouse gases (GHGs) and short-lived species (SLS), land use and land cover change (LULCC), and other resource-related drivers of anthropogenic climate change. ESMs are the primary scientific tools for examining the physical, chemical, and biogeochemical impacts of human-induced changes to the climate system. The iESM project integrates the economic and human-dimension modeling of an IAM and a fully coupled ESM within a single simulation system while maintaining the separability of each model if needed. Both IAM and ESM codes are developed and used by large communities and have been extensively applied in recent national and international climate assessments. By introducing heretofore-omitted feedbacks between natural and societal drivers, we can improve scientific understanding of the human-Earth system dynamics. Potential applications include studies of the interactions and feedbacks leading to the timing, scale, and geographic distribution of emissions trajectories and other human influences, corresponding climate effects, and the subsequent impacts of a changing climate on human and natural systems. This paper describes the formulation, requirements, implementation, testing, and resulting functionality of the first version of the iESM released to the global climate community.

  9. Integrated System Health Management Development Toolkit

    NASA Technical Reports Server (NTRS)

    Figueroa, Jorge; Smith, Harvey; Morris, Jon

    2009-01-01

    This software toolkit is designed to model complex systems for the implementation of embedded Integrated System Health Management (ISHM) capability, which focuses on determining the condition (health) of every element in a complex system (detect anomalies, diagnose causes, and predict future anomalies), and to provide data, information, and knowledge (DIaK) to control systems for safe and effective operation.

  10. Integrated Collision Avoidance System for Air Vehicle

    NASA Technical Reports Server (NTRS)

    Lin, Ching-Fang (Inventor)

    2013-01-01

    Collision with ground/water/terrain and midair obstacles is one of the common causes of severe aircraft accidents. The various data from the coremicro AHRS/INS/GPS Integration Unit, terrain data base, and object detection sensors are processed to produce collision warning audio/visual messages and collision detection and avoidance of terrain and obstacles through generation of guidance commands in a closed-loop system. The vision sensors provide more information for the Integrated System, such as, terrain recognition and ranging of terrain and obstacles, which plays an important role to the improvement of the Integrated Collision Avoidance System.

  11. Integration of mobile satellite and cellular systems

    NASA Technical Reports Server (NTRS)

    Drucker, Elliott H.; Estabrook, Polly; Pinck, Deborah; Ekroot, Laura

    1993-01-01

    By integrating the ground based infrastructure component of a mobile satellite system with the infrastructure systems of terrestrial 800 MHz cellular service providers, a seamless network of universal coverage can be established. Users equipped for both cellular and satellite service can take advantage of a number of features made possible by such integration, including seamless handoff and universal roaming. To provide maximum benefit at lowest posible cost, the means by which these systems are integrated must be carefully considered. Mobile satellite hub stations must be configured to efficiently interface with cellular Mobile Telephone Switching Offices (MTSO's), and cost effective mobile units that provide both cellular and satellite capability must be developed.

  12. Hyperelliptic Prym Varieties and Integrable Systems

    NASA Astrophysics Data System (ADS)

    Fernandes, Rui Loja; Vanhaecke, Pol

    We introduce two algebraic completely integrable analogues of the Mumford systems which we call hyperelliptic Prym systems, because every hyperelliptic Prym variety appears as a fiber of their momentum map. As an application we show that the general fiber of the momentum map of the periodic Volterra lattice is an affine part of a hyperelliptic Prym variety, obtained by removing n translates of the theta divisor, and we conclude that this integrable system is algebraic completely integrable.

  13. Lax operator algebras and integrable systems

    NASA Astrophysics Data System (ADS)

    Sheinman, O. K.

    2016-02-01

    A new class of infinite-dimensional Lie algebras, called Lax operator algebras, is presented, along with a related unifying approach to finite-dimensional integrable systems with a spectral parameter on a Riemann surface such as the Calogero-Moser and Hitchin systems. In particular, the approach includes (non-twisted) Kac-Moody algebras and integrable systems with a rational spectral parameter. The presentation is based on quite simple ideas about the use of gradings of semisimple Lie algebras and their interaction with the Riemann-Roch theorem. The basic properties of Lax operator algebras and the basic facts about the theory of the integrable systems in question are treated (and proved) from this general point of view. In particular, the existence of commutative hierarchies and their Hamiltonian properties are considered. The paper concludes with an application of Lax operator algebras to prequantization of finite-dimensional integrable systems. Bibliography: 51 titles.

  14. Capability for Integrated Systems Risk-Reduction Analysis

    NASA Technical Reports Server (NTRS)

    Mindock, J.; Lumpkins, S.; Shelhamer, M.

    2016-01-01

    NASA's Human Research Program (HRP) is working to increase the likelihoods of human health and performance success during long-duration missions, and subsequent crew long-term health. To achieve these goals, there is a need to develop an integrated understanding of how the complex human physiological-socio-technical mission system behaves in spaceflight. This understanding will allow HRP to provide cross-disciplinary spaceflight countermeasures while minimizing resources such as mass, power, and volume. This understanding will also allow development of tools to assess the state of and enhance the resilience of individual crewmembers, teams, and the integrated mission system. We will discuss a set of risk-reduction questions that has been identified to guide the systems approach necessary to meet these needs. In addition, a framework of factors influencing human health and performance in space, called the Contributing Factor Map (CFM), is being applied as the backbone for incorporating information addressing these questions from sources throughout HRP. Using the common language of the CFM, information from sources such as the Human System Risk Board summaries, Integrated Research Plan, and HRP-funded publications has been combined and visualized in ways that allow insight into cross-disciplinary interconnections in a systematic, standardized fashion. We will show examples of these visualizations. We will also discuss applications of the resulting analysis capability that can inform science portfolio decisions, such as areas in which cross-disciplinary solicitations or countermeasure development will potentially be fruitful.

  15. Control architecture for human-robot integration: application to a robotic wheelchair.

    PubMed

    Galindo, Cipriano; Gonzalez, Javier; Fernández-Madrigal, Juan-Antonio

    2006-10-01

    Completely autonomous performance of a mobile robot within noncontrolled and dynamic environments is not possible yet due to different reasons including environment uncertainty, sensor/software robustness, limited robotic abilities, etc. But in assistant applications in which a human is always present, she/he can make up for the lack of robot autonomy by helping it when needed. In this paper, the authors propose human-robot integration as a mechanism to augment/improve the robot autonomy in daily scenarios. Through the human-robot-integration concept, the authors take a further step in the typical human-robot relation, since they consider her/him as a constituent part of the human-robot system, which takes full advantage of the sum of their abilities. In order to materialize this human integration into the system, they present a control architecture, called architecture for human-robot integration, which enables her/him from a high decisional level, i.e., deliberating a plan, to a physical low level, i.e., opening a door. The presented control architecture has been implemented to test the human-robot integration on a real robotic application. In particular, several real experiences have been conducted on a robotic wheelchair aimed to provide mobility to elderly people. PMID:17036812

  16. [Human resources for local health systems].

    PubMed

    Linger, C

    1989-01-01

    The economic and social crises affecting Latin America have had a profound social and political effect on its structures. This paper analyzes this impact from 2 perspectives: 1) the impact on the apparatus of the state, in particular on its health infra-structures; and 2) the direction of the democratic process in the continent and the participatory processes of civil societies. The institutionalization of the Local Health Systems (SILOS) is an effort to analyze the problem from within the health sector and propose solutions. This paper discusses the issues of human resource development in health systems; training in human resource development and human resource development in local health care systems. There are 3 strategies used to change health systems: 1) The judicial-political system: The state's apparatus 2) The political-administrative system: the national health care system; and 3) the political-operative system: local health care systems. To assure implementation of SILOS there are 4 steps to be followed: 1) create political conditions that allow the transformation and development of local health systems; 2) development of high-level institutional and political initiatives to develop health care networks; 3) offer key players institutional space and social action to develop the SILOS process; 4) rapidly develop SILOS in regions to assure its integration with other development efforts. The labor force in the health sector and organized communities play critical roles in proposing and institutionalizing health programs. PMID:2766984

  17. Partial Automated Alignment and Integration System

    NASA Technical Reports Server (NTRS)

    Kelley, Gary Wayne (Inventor)

    2014-01-01

    The present invention is a Partial Automated Alignment and Integration System (PAAIS) used to automate the alignment and integration of space vehicle components. A PAAIS includes ground support apparatuses, a track assembly with a plurality of energy-emitting components and an energy-receiving component containing a plurality of energy-receiving surfaces. Communication components and processors allow communication and feedback through PAAIS.

  18. Human Message Systems.

    ERIC Educational Resources Information Center

    Hopper, Robert

    A long-standing dispute over the best way to teach communication involves two major positions: teaching communication through practice/performance and teaching communication through theories and principles. This book describes both theories and practices, offering ideas within a systems framework so that each chapter introduces interacting…

  19. HGDBMS: a human genetics database management system.

    PubMed

    Seuchter, S A; Skolnick, M H

    1988-10-01

    Human genetics research involves a large number of complex data sets naturally organized in hierarchical structures. Data collection is performed on different levels, e.g., the project level, pedigree level, individual level, and sample level. Different aspects of a study utilize different views of the data, requiring a flexible database management system (DBMS) which satisfies these different needs for data collection and retrieval. We describe HGDBMS, a comprehensive relational DBMS, implemented as an application of the GENISYS I DBMS, which allows embedding the hierarchical structure of pedigrees in a relational structure. The system's file structure is described in detail. Currently our Melanoma and Chromosome 17 map studies are managed with HGDBMS. Our initial experience demonstrates the value of a flexible system which supports the needs for data entry, update, storage, reporting, and analysis required during different phases of genetic research. Further developments will focus on the integration of HGDBMS with a human genetics expert system shell and analysis programs. PMID:3180747

  20. An integrated model of human-wildlife interdependence

    USGS Publications Warehouse

    John, Kun H.; Walsh, Richard G.; Johnson, R. L.

    1994-01-01

    This paper attempts to integrate wildlife-related ecologic and economic variables into an econometric model. The model reveals empirical evidence of the presumed interdependence of human-wildlife and the holistic nature of humanity's relationship to the ecosystem. Human use of biologic resources varies not only with income, education, and population, but also with sustainability of humankind's action relative to the quality and quantity of the supporting ecological base.

  1. Human gesture recognition using three-dimensional integral imaging.

    PubMed

    Javier Traver, V; Latorre-Carmona, Pedro; Salvador-Balaguer, Eva; Pla, Filiberto; Javidi, Bahram

    2014-10-01

    Three-dimensional (3D) integral imaging allows one to reconstruct a 3D scene, including range information, and provides sectional refocused imaging of 3D objects at different ranges. This paper explores the potential use of 3D passive sensing integral imaging for human gesture recognition tasks from sequences of reconstructed 3D video scenes. As a preliminary testbed, the 3D integral imaging sensing is implemented using an array of cameras with the appropriate algorithms for 3D scene reconstruction. Recognition experiments are performed by acquiring 3D video scenes of multiple hand gestures performed by ten people. We analyze the capability and performance of gesture recognition using 3D integral imaging representations at given distances and compare its performance with the use of standard two-dimensional (2D) single-camera videos. To the best of our knowledge, this is the first report on using 3D integral imaging for human gesture recognition. PMID:25401260

  2. Integrability of Hamiltonian systems with algebraic potentials

    NASA Astrophysics Data System (ADS)

    Maciejewski, Andrzej J.; Przybylska, Maria

    2016-01-01

    Problem of integrability for Hamiltonian systems with potentials that are algebraic thus multivalued functions of coordinates is discussed. Introducing potential as a new variable the original Hamiltonian system on 2n dimensional phase space is extended to 2 n + 1 dimensional system with rational right-hand sides. For extended system its non-canonical degenerated Poisson structure of constant rank 2n and rational Hamiltonian is identified. For algebraic homogeneous potentials of non-zero rational homogeneity degree necessary integrability conditions are formulated. These conditions are deduced from an analysis of the differential Galois group of variational equations around particular solutions of a straight line type. Obtained integrability obstructions are applied to the class of monomial homogeneous potentials. Some integrable potentials satisfying these conditions are found.

  3. INTEGRATED WATER TREATMENT SYSTEM PERFORMANCE EVALUATION

    SciTech Connect

    SEXTON RA; MEEUWSEN WE

    2009-03-12

    This document describes the results of an evaluation of the current Integrated Water Treatment System (IWTS) operation against design performance and a determination of short term and long term actions recommended to sustain IWTS performance.

  4. Energy Systems Integration: NREL + Solectria (Fact Sheet)

    SciTech Connect

    Not Available

    2015-02-01

    This fact sheet describes the collaboration between NREL and Solectria at the Energy Systems Integration Facility (ESIF) to to develop 500- and 750-kilowatt photovoltaic (PV) inverters with advanced features that can support the electric grid.

  5. Chip scale integrated microresonator sensing systems.

    PubMed

    Jokerst, Nan; Royal, Matthew; Palit, Sabarni; Luan, Lin; Dhar, Sulochana; Tyler, Talmage

    2009-04-01

    Medicine, environmental monitoring, and security are application areas for miniaturized, portable sensing systems. The emerging integration of sensors with other components (electronic, photonic, fluidic) is moving sensing toward higher levels of portability through the realization of self-contained chip scale sensing systems. Planar optical sensors, and in particular, microresonator sensors, are attractive components for chip scale integrated sensing systems because they are small, have high sensitivity, can be surface customized, and can be integrated singly or in arrays in a planar format with other components using conventional semiconductor fabrication technologies. This paper will focus on the progress and prospects for the integration of microresonator sensors at the chip scale with photonic input/output components and with sample preparation microfluidics, toward self-contained, portable sensing systems. PMID:19367589

  6. Integrative System of Fast Photoacoustic Imaging

    NASA Astrophysics Data System (ADS)

    Yi, Tan

    An integrative fast (Photoacoustic) PA imaging system based on multi-element linear ultrasonic transducer array was developed, which integrates laser delivery, photoacoustic excitation and photoacoustic detection into a portable system. It collects PA signals by a multi-element linear transducer array in a reflection mode. The PA images with high spatial resolution and high contrast were obtained. Compared to other existing PA imaging methods, the integrative PA imaging system is characterized by rapidness, convenience and high practicality. The integrative system is mobile and portable, and it is suitable for imaging samples in natural condition with various different shapes. It will provide a novel and effective PA imaging approach for clinic diagnosis of neoplasm and tissue functional imaging in vivo, and has potential to be developed into a practical apparatus used in the early non-invasive detection of breast-cancer.

  7. Integrated restructurable flight control system demonstration results

    NASA Technical Reports Server (NTRS)

    Weiss, Jerold L.; Hsu, John Y.

    1987-01-01

    The purpose of this study was to examine the complementary capabilities of several restructurable flight control system (RFCS) concepts through the integration of these technologies into a complete system. Performance issues were addressed through a re-examination of RFCS functional requirements, and through a qualitative analysis of the design issues that, if properly addressed during integration, will lead to the highest possible degree of fault-tolerant performance. Software developed under previous phases of this contract and under NAS1-18004 was modified and integrated into a complete RFCS subroutine for NASA's B-737 simulation. The integration of these modules involved the development of methods for dealing with the mismatch between the outputs of the failure detection module and the input requirements of the automatic control system redesign module. The performance of this demonstration system was examined through extensive simulation trials.

  8. Human performance modeling for system of systems analytics :soldier fatigue.

    SciTech Connect

    Lawton, Craig R.; Campbell, James E.; Miller, Dwight Peter

    2005-10-01

    The military has identified Human Performance Modeling (HPM) as a significant requirement and challenge of future systems modeling and analysis initiatives as can be seen in the Department of Defense's (DoD) Defense Modeling and Simulation Office's (DMSO) Master Plan (DoD 5000.59-P 1995). To this goal, the military is currently spending millions of dollars on programs devoted to HPM in various military contexts. Examples include the Human Performance Modeling Integration (HPMI) program within the Air Force Research Laboratory, which focuses on integrating HPMs with constructive models of systems (e.g. cockpit simulations) and the Navy's Human Performance Center (HPC) established in September 2003. Nearly all of these initiatives focus on the interface between humans and a single system. This is insufficient in the era of highly complex network centric SoS. This report presents research and development in the area of HPM in a system-of-systems (SoS). Specifically, this report addresses modeling soldier fatigue and the potential impacts soldier fatigue can have on SoS performance.

  9. SUBSURFACE REPOSITORY INTEGRATED CONTROL SYSTEM DESIGN

    SciTech Connect

    D.C. Randle

    2000-01-07

    The primary purpose of this document is to develop a preliminary high-level functional and physical control system architecture for the potential repository at Yucca Mountain. This document outlines an overall control system concept that encompasses and integrates the many diverse process and communication systems being developed for the subsurface repository design. This document presents integrated design concepts for monitoring and controlling the diverse set of subsurface operations. The Subsurface Repository Integrated Control System design will be composed of a series of diverse process systems and communication networks. The subsurface repository design contains many systems related to instrumentation and control (I&C) for both repository development and waste emplacement operations. These systems include waste emplacement, waste retrieval, ventilation, radiological and air monitoring, rail transportation, construction development, utility systems (electrical, lighting, water, compressed air, etc.), fire protection, backfill emplacement, and performance confirmation. Each of these systems involves some level of I&C and will typically be integrated over a data communications network throughout the subsurface facility. The subsurface I&C systems will also interface with multiple surface-based systems such as site operations, rail transportation, security and safeguards, and electrical/piped utilities. In addition to the I&C systems, the subsurface repository design also contains systems related to voice and video communications. The components for each of these systems will be distributed and linked over voice and video communication networks throughout the subsurface facility. The scope and primary objectives of this design analysis are to: (1) Identify preliminary system-level functions and interfaces (Section 6.2). (2) Examine the overall system complexity and determine how and on what levels the engineered process systems will be monitored, controlled, and

  10. Fundamentals of fuel cell system integration

    NASA Astrophysics Data System (ADS)

    Krumpelt, Michael; Kumar, Romesh; Myles, Kevin M.

    1994-04-01

    Fuel cells are theoretically very efficient energy conversion devices that have the potential of becoming a commercial product for numerous uses in the civilian economy. We have analyzed several fuel cell system designs with regard to thermal and chemical integration of the fuel cell stack into the rest of the system. Thermal integration permits the use of the stack waste heat for the endothermic steps of fuel reforming. Chemical integration provides the steam needed for fuel reforming from the water produced by the electrochemical cell reaction. High-temperature fuel cells, such as the molten carbonate and the solid oxide fuel cells, permit this system integration in a relatively simple manner. Lower temperature fuel cells, such as the polymer electrolyte and phosphoric acid systems, require added system complexity to achieve such integration. The system economics are affected by capital and fuel costs and technical parameters, such as electrochemical fuel utilization, current density, and system complexity. At today's low fuel prices and the high fuel cell costs (in part, because of the low rates of production of the early prototypes), fuel cell systems are not cost competitive with conventional power generation. With the manufacture and sale of larger numbers of fuel cell systems, the total costs will decrease from the current several thousand dollars per kW, to perhaps less than $100 per kW as production volumes approa ch a million units per year.

  11. Exact quantization conditions for cluster integrable systems

    NASA Astrophysics Data System (ADS)

    Franco, Sebastián; Hatsuda, Yasuyuki; Mariño, Marcos

    2016-06-01

    We propose exact quantization conditions for the quantum integrable systems of Goncharov and Kenyon, based on the enumerative geometry of the corresponding toric Calabi–Yau manifolds. Our conjecture builds upon recent results on the quantization of mirror curves, and generalizes a previous proposal for the quantization of the relativistic Toda lattice. We present explicit tests of our conjecture for the integrable systems associated to the resolved {{{C}}3}/{{{Z}}5} and {{{C}}3}/{{{Z}}6} orbifolds.

  12. Vehicle Systems Integration Laboratory Accelerates Powertrain Development

    SciTech Connect

    2014-04-15

    ORNL's Vehicle Systems Integration (VSI) Laboratory accelerates the pace of powertrain development by performing prototype research and characterization of advanced systems and hardware components. The VSI Lab is capable of accommodating a range of platforms from advanced light-duty vehicles to hybridized Class 8 powertrains with the goals of improving overall system efficiency and reducing emissions.

  13. The Integrated Library System: A Historical Overview.

    ERIC Educational Resources Information Center

    Dick, Richard S.

    1984-01-01

    Discusses evolution of Integrated Library System (ILS) since its beginning at National Library of Medicine, highlighting events leading to ILS development; formative design stages, formation of Online Computer System; installation of ILS version 1.0 at Pentagon library; development of version 2.0, formation of Avatar Systems; OCLC's acquisition of…

  14. Vehicle Systems Integration Laboratory Accelerates Powertrain Development

    ScienceCinema

    None

    2014-06-25

    ORNL's Vehicle Systems Integration (VSI) Laboratory accelerates the pace of powertrain development by performing prototype research and characterization of advanced systems and hardware components. The VSI Lab is capable of accommodating a range of platforms from advanced light-duty vehicles to hybridized Class 8 powertrains with the goals of improving overall system efficiency and reducing emissions.

  15. Integration Testing of Space Flight Systems

    NASA Technical Reports Server (NTRS)

    Sowards, Stephanie; Honeycutt, Timothy

    2008-01-01

    This paper discusses the benefits of conducting multi-system integration testing of space flight elements in lieu of merely shipping and shooting to the launch site and launching. "Ship and shoot" is a philosophy that proposes to transport flight elements directly from the factory to the launch site and begin the mission without further testing. Integration testing, relevant to validation testing in this context, is a risk mitigation effort that builds upon the individual element and system levels of qualification and acceptance tests, greatly improving the confidence of operations in space. The International Space Station Program (ISSP) experience is the focus of most discussions from a historical perspective, while proposed integration testing of the Constellation Program is also discussed. The latter will include Multi-Element Integration Testing (MElT) and Flight Element Integration Testing (FElT).

  16. Coal Integrated Gasification Fuel Cell System Study

    SciTech Connect

    Chellappa Balan; Debashis Dey; Sukru-Alper Eker; Max Peter; Pavel Sokolov; Greg Wotzak

    2004-01-31

    This study analyzes the performance and economics of power generation systems based on Solid Oxide Fuel Cell (SOFC) technology and fueled by gasified coal. System concepts that integrate a coal gasifier with a SOFC, a gas turbine, and a steam turbine were developed and analyzed for plant sizes in excess of 200 MW. Two alternative integration configurations were selected with projected system efficiency of over 53% on a HHV basis, or about 10 percentage points higher than that of the state-of-the-art Integrated Gasification Combined Cycle (IGCC) systems. The initial cost of both selected configurations was found to be comparable with the IGCC system costs at approximately $1700/kW. An absorption-based CO2 isolation scheme was developed, and its penalty on the system performance and cost was estimated to be less approximately 2.7% and $370/kW. Technology gaps and required engineering development efforts were identified and evaluated.

  17. NASA Docking System (NDS) Technical Integration Meeting

    NASA Technical Reports Server (NTRS)

    Lewis, James L.

    2010-01-01

    This slide presentation reviews the NASA Docking System (NDS) as NASA's implementation of the International Docking System Standard (IDSS). The goals of the NDS, is to build on proven technologies previously demonstrated in flight and to advance the state of the art of docking systems by incorporating Low Impact Docking System (LIDS) technology into the NDS. A Hardware Demonstration was included in the meeting, and there was discussion about software, NDS major system interfaces, integration information, schedule, and future upgrades.

  18. Human factors in underwater systems.

    PubMed

    Crosson, D

    1993-10-01

    Applications of human factors to undersea engineering and the relationship to aerospace science are explored. Cooperative ventures include the TEKTITE underwater habitat and development of better procedures to prevent decompression sickness. Other research involved the use of alternate gases in diving systems, remote-operation vehicles, and diving system tests. PMID:11541030

  19. Advanced optical manufacturing digital integrated system

    NASA Astrophysics Data System (ADS)

    Tao, Yizheng; Li, Xinglan; Li, Wei; Tang, Dingyong

    2012-10-01

    It is necessarily to adapt development of advanced optical manufacturing technology with modern science technology development. To solved these problems which low of ration, ratio of finished product, repetition, consistent in big size and high precision in advanced optical component manufacturing. Applied business driven and method of Rational Unified Process, this paper has researched advanced optical manufacturing process flow, requirement of Advanced Optical Manufacturing integrated System, and put forward architecture and key technology of it. Designed Optical component core and Manufacturing process driven of Advanced Optical Manufacturing Digital Integrated System. the result displayed effective well, realized dynamic planning Manufacturing process, information integration improved ratio of production manufactory.

  20. Seal system with integral detector

    DOEpatents

    Fiarman, Sidney

    1985-01-01

    There is disclosed a seal system for materials where security is of the essence, such as nuclear materials, which is tamper-indicating, which indicates changes in environmental conditions that evidence attempts to by-pass the seal, which is unique and cost effective, said seal system comprised of a seal where an optical signal is transmitted through a loop, with a detector to read said signal, and one or more additional detectors designed to detect environmental changes, these detectors being operatively associated with the seal so that detection of a break in the optical signal or detection of environmental changes will cause an observable change in the seal.

  1. Seal system with integral detector

    DOEpatents

    Fiarman, S.

    1982-08-12

    A seal system is disclosed for materials where security is of the essence, such as nuclear materials. The seal is tamper-indicating, indicates changes in environmental conditions that evidence attempts to bypass the seal, is unique and cost effective. The seal system is comprised of a seal where an optical signal is transmitted through a loop, with a detector to read said signal, and one or more additional detectors designed to detect environmental changes, these detectors being operatively associated with the seal so that detection of a break in the optical signal or detection of environmental changes will cause an observable change in the seal.

  2. Development of an Integrated Distribution Management System

    SciTech Connect

    Schatz, Joe E.

    2010-10-20

    This final report details the components, functionality, costs, schedule and benefits of developing an Integrated Distribution Management System (IDMS) for power distribution system operation. The Distribution Automation (DA) and Supervisory Control and Data Acquisition (SCADA) systems used by electric power companies to manage the distribution of electric power to retail energy consumers are vital components of the Nation’s critical infrastructure. Providing electricity is an essential public service and a disruption in that service, if not quickly restored, could threaten the public safety and the Nation’s economic security. Our Nation’s economic prosperity and quality of life have long depended on the essential services that utilities provide; therefore, it is necessary to ensure that electric utilities are able to conduct their operations safely and efficiently. A fully integrated technology of applications is needed to link various remote sensing, communications and control devices with other information tools that help guide Power Distribution Operations personnel. A fully implemented IDMS will provide this, a seamlessly integrated set of applications to raise electric system operating intelligence. IDMS will enhance DA and SCADA through integration of applications such as Geographic Information Systems, Outage Management Systems, Switching Management and Analysis, Operator Training Simulator, and other Advanced Applications, including unbalanced load flow and fault isolation/service restoration. These apps are capable of utilizing and obtaining information from appropriately installed DER, and by integrating disparate systems, the Distribution Operators will benefit from advanced capabilities when analyzing, controlling and operating the electric system.

  3. Robust Integrated Neurocontroller for Complex Dynamic Systems

    NASA Technical Reports Server (NTRS)

    Zein-Sabatto, S.; Marpaka, D.; Hwang, W.

    1996-01-01

    The goal of this research effort is to develop an integrated control software environment for the purpose of creating an intelligent neurocontrol system. The system will be capable of estimating states, identifying parameters, diagnosing conditions, planning control strategies, and producing intelligent control actions. The distinct features of such control system are: adaptability and on-line learning capability. The proposed system will be flexible to allow structure adaptability to account for changes in the dynamic system such as: sensory failures and/or component degradations. The developed system should learn system uncertainties and changes, as they occur, while maintaining minimal control level on the dynamic system. The research activities set to achieve the research objective are summarized by the following general items: (1) Development of a system identifier or diagnostic system, (2) Development of a robust neurocontroller system, and 3. Integration of above systems to create a Robust Integrated Control system (RIC-system). Two contrary approaches are investigated in this research: classical (traditional) design approach, and the simultaneous design approach. However, in both approaches neural network is the base for the development of different functions of the system. The two resulting designs will be tested and simulation results will be compared for better possible implementation.

  4. Robust integrated neurocontroller for complex dynamic systems

    NASA Technical Reports Server (NTRS)

    Zein-Sabbato, S.; Marpaka, D.; Hwang, W.

    1995-01-01

    The goal of this research effort is to develop an integrated control software environment for the purpose of creating an intelligent neurocontrol system. The system will be capable of estimating states, identifying parameters, diagnosing conditions, planning control strategies, and producing intelligent control actions. The distinct features of such control system are adaptability and on-line learning capability. The proposed system will be flexible to allow structure adaptability to account for changes in the dynamic system such as sensory failures and/or component degradations. The developed system should learn system uncertainties and changes, as they occur, while maintaining minimal control level on the dynamic system. The research activities set to achieve the research objective are summarized by the following general items: (1) Development of a system identifier or diagnostic system; (2) Development of a robust neurocontroller system, and; (3) Integration of above systems to create a robust Integration Control system (RIC-system). Two contrary approaches are investigated in this research: classical (traditional) design approach, and the simultaneous design approach. However, in both approaches neural network is the base for the development of different functions of the system. The two resulting designs will be tested and simulation results will be compared for better possible implementation.

  5. Integrated support systems for electric utility operations

    SciTech Connect

    Hong, H.W.; Imparato, C.F.; Becker, D.L.; Malinowski, J.H. )

    1992-01-01

    Power system dispatch, the real-time monitoring and coordination of transmission and generation facilities, is the focal point of power system operations. However, dispatch is just one of the many duties of the typical power system operations department. Many computer-based tools and systems are used in support of these duties. Energy management systems (EMS), the centralized, mainframe-, or mini-computer-based systems that support dispatch, have been widely publicized, but few of the other support systems have been given much notice. This article provides an overview of these support tools and systems, frames the major issues faced in systems integration, and describes the path taken to integrate EMS, workstations, desktop computers, networks and applications. Network architecture enables the distribution of real-time operations data throughout the company, from EMS to power plants to district offices, on an unprecedented scale.

  6. Energy Systems Integration: A Convergence of Ideas

    SciTech Connect

    Kroposki, B.; Garrett, B.; MacMillan, S.; Rice, B.; Komomua, C.; O'Malley, M.; Zimmerle, D.

    2012-07-01

    Energy systems integration (ESI) enables the effective analysis, design, and control of these interactions and interdependencies along technical, economic, regulatory, and social dimensions. By focusing on the optimization of energy from all systems, across all pathways, and at all scales, we can better understand and make use of the co-benefits that result to increase reliability and performance, reduce cost, and minimize environmental impacts. This white paper discusses systems integration and the research in new control architectures that are optimized at smaller scales but can be aggregated to optimize energy systems at any scale and would allow replicable energy solutions across boundaries of existing and new energy pathways.

  7. An integrated multimedia medical information network system.

    PubMed

    Yamamoto, K; Makino, J; Sasagawa, N; Nagira, M

    1998-01-01

    An integrated multimedia medical information network system at Shimane Medical university has been developed to organize medical information generated from each section and provide information services useful for education, research and clinical practice. The report describes the outline of our system. It is designed to serve as a distributed database for electronic medical records and images. We are developing the MML engine that is to be linked to the world wide web (WWW) network system. To the users, this system will present an integrated multimedia representation of the patient records, providing access to both the image and text-based data required for an effective clinical decision making and medical education. PMID:10384445

  8. VA's Integrated Imaging System on three platforms.

    PubMed

    Dayhoff, R E; Maloney, D L; Majurski, W J

    1992-01-01

    The DHCP Integrated Imaging System provides users with integrated patient data including text, image and graphics data. This system has been transferred from its original two screen DOS-based MUMPS platform to an X window workstation and a Microsoft Windows-based workstation. There are differences between these various platforms that impact on software design and on software development strategy. Data structures and conventions were used to isolate hardware, operating system, imaging software, and user-interface differences between platforms in the implementation of functionality for text and image display and interaction. The use of an object-oriented approach greatly increased system portability. PMID:1482983

  9. INTEGRATED ROBOT-HUMAN CONTROL IN MINING OPERATIONS

    SciTech Connect

    George Danko

    2005-04-01

    This report contains a detailed description of the work conducted in the first year of the project on Integrated Robot-Human Control in Mining Operations at University of Nevada, Reno. This project combines human operator control with robotic control concepts to create a hybrid control architecture, in which the strengths of each control method are combined to increase machine efficiency and reduce operator fatigue. The kinematics reconfiguration type differential control of the excavator implemented with a variety of ''software machine kinematics'' is the key feature of the project. This software re-configured excavator is more desirable to execute a given digging task. The human operator retains the master control of the main motion parameters, while the computer coordinates the repetitive movement patterns of the machine links. These repetitive movements may be selected from a pre-defined family of trajectories with different transformations. The operator can make adjustments to this pattern in real time, as needed, to accommodate rapidly-changing environmental conditions. A Bobcat{reg_sign} 435 excavator was retrofitted with electro-hydraulic control valve elements. The modular electronic control was tested and the basic valve characteristics were measured for each valve at the Robotics Laboratory at UNR. Position sensors were added to the individual joint control actuators, and the sensors were calibrated. An electronic central control system consisting of a portable computer, converters and electronic driver components was interfaced to the electro-hydraulic valves and position sensors. The machine is operational with or without the computer control system depending on whether the computer interface is on or off. In preparation for emulated mining tasks tests, typical, repetitive tool trajectories during surface mining operations were recorded at the Newmont Mining Corporation's ''Lone Tree'' mine in Nevada.

  10. Integrating automated systems with modular architecture

    SciTech Connect

    Salit, M.L.; Guenther, F.R.; Kramer, G.W. ); Griesmeyer, J.M. )

    1994-03-15

    The modularity project of the Consortium for Automated Analytical Laboratory Systems, or CAALS, has been working to define and produce specifications with which manufacturers of analytical equipment can produce products suited for integration into automated systems. A set of standards that will allow subsystems to be configured into robust, useful, controllable systems in a stylized, consistent manner will facilitate the development and integration process. Such standards could ultimately allow an analytical chemist to select devices from a heterogeneous set of vendors and integrate those devices into a work cell to perform chemical methods without further invention, computer programming, or engineering. Our approach to this formidable task is to view analytical chemistry in an abstract fashion, forming a generic model from the understanding of what it is we do. In this article, we report on the generic model and the integration architecture we have developed to implement it. 6 refs., 3 figs.

  11. Integrated Evaluation of Closed Loop Air Revitalization System Components

    NASA Technical Reports Server (NTRS)

    Murdock, K.

    2010-01-01

    NASA s vision and mission statements include an emphasis on human exploration of space, which requires environmental control and life support technologies. This Contractor Report (CR) describes the development and evaluation of an Air Revitalization System, modeling and simulation of the components, and integrated hardware testing with the goal of better understanding the inherent capabilities and limitations of this closed loop system. Major components integrated and tested included a 4-Bed Modular Sieve, Mechanical Compressor Engineering Development Unit, Temperature Swing Adsorption Compressor, and a Sabatier Engineering and Development Unit. The requisite methodolgy and technical results are contained in this CR.

  12. Lean Big Data Integration in Systems Biology and Systems Pharmacology

    PubMed Central

    Ma’ayan, Avi; Rouillard, Andrew D.; Clark, Neil R.; Wang, Zichen; Duan, Qiaonan; Kou, Yan

    2014-01-01

    Datasets from recent large-scale projects can be integrated into one unified puzzle that can provide new insights into how drugs and genetic perturbations applied to human cells are linked to whole organism phenotypes. Data that report how drugs affect the phenotype of human cell-lines, and how drugs induce changes in gene and protein expression in human cell-lines, can be combined with knowledge about human disease, side effects induced by drugs, and mouse phenotypes. Such data integration effort can be achieved through the conversion of data from the various resources into single-node-type networks, gene-set libraries, or multi-partite graphs. This approach can lead us to the identification of more relationships between genes, drugs and phenotypes, as well as benchmark computational and experimental methods. Overall this lean “Big Data” integration strategy will bring us closer toward the goal of realizing personalized medicine. PMID:25109570

  13. Vertically integrated analysis of human DNA. Final technical report

    SciTech Connect

    Olson, M.

    1997-10-01

    This project has been oriented toward improving the vertical integration of the sequential steps associated with the large-scale analysis of human DNA. The central focus has been on an approach to the preparation of {open_quotes}sequence-ready{close_quotes} maps, which is referred to as multiple-complete-digest (MCD) mapping, primarily directed at cosmid clones. MCD mapping relies on simple experimental steps, supported by advanced image-analysis and map-assembly software, to produce extremely accurate restriction-site and clone-overlap maps. We believe that MCD mapping is one of the few high-resolution mapping systems that has the potential for high-level automation. Successful automation of this process would be a landmark event in genome analysis. Once other higher organisms, paving the way for cost-effective sequencing of these genomes. Critically, MCD mapping has the potential to provide built-in quality control for sequencing accuracy and to make possible a highly integrated end product even if there are large numbers of discontinuities in the actual sequence.

  14. Human Research Program Integrated Research Plan. Revision A January 2009

    NASA Technical Reports Server (NTRS)

    2009-01-01

    The Integrated Research Plan (IRP) describes the portfolio of Human Research Program (HRP) research and technology tasks. The IRP is the HRP strategic and tactical plan for research necessary to meet HRP requirements. The need to produce an IRP is established in HRP-47052, Human Research Program - Program Plan, and is under configuration management control of the Human Research Program Control Board (HRPCB). Crew health and performance is critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) is essential to enabling extended periods of space exploration because it provides knowledge and tools to mitigate risks to human health and performance. Risks include physiological and behavioral effects from radiation and hypogravity environments, as well as unique challenges in medical support, human factors, and behavioral or psychological factors. The Human Research Program (HRP) delivers human health and performance countermeasures, knowledge, technologies and tools to enable safe, reliable, and productive human space exploration. Without HRP results, NASA will face unknown and unacceptable risks for mission success and post-mission crew health. This Integrated Research Plan (IRP) describes HRP s approach and research activities that are intended to address the needs of human space exploration and serve HRP customers and how they are integrated to provide a risk mitigation tool. The scope of the IRP is limited to the activities that can be conducted with the resources available to the HRP; it does not contain activities that would be performed if additional resources were available. The timescale of human space exploration is envisioned to take many decades. The IRP illustrates the program s research plan through the timescale of early lunar missions of extended duration.

  15. The integration hypothesis of human language evolution and the nature of contemporary languages

    PubMed Central

    Miyagawa, Shigeru; Ojima, Shiro; Berwick, Robert C.; Okanoya, Kazuo

    2014-01-01

    How human language arose is a mystery in the evolution of Homo sapiens. Miyagawa et al. (2013) put forward a proposal, which we will call the Integration Hypothesis of human language evolution, that holds that human language is composed of two components, E for expressive, and L for lexical. Each component has an antecedent in nature: E as found, for example, in birdsong, and L in, for example, the alarm calls of monkeys. E and L integrated uniquely in humans to give rise to language. A challenge to the Integration Hypothesis is that while these non-human systems are finite-state in nature, human language is known to require characterization by a non-finite state grammar. Our claim is that E and L, taken separately, are in fact finite-state; when a grammatical process crosses the boundary between E and L, it gives rise to the non-finite state character of human language. We provide empirical evidence for the Integration Hypothesis by showing that certain processes found in contemporary languages that have been characterized as non-finite state in nature can in fact be shown to be finite-state. We also speculate on how human language actually arose in evolution through the lens of the Integration Hypothesis. PMID:24936195

  16. Integrated Intermodal Passenger Transportation System

    NASA Technical Reports Server (NTRS)

    Klock, Ryan; Owens, David; Schwartz, Henry; Plencner, Robert

    2012-01-01

    Modern transportation consists of many unique modes of travel. Each of these modes and their respective industries has evolved independently over time, forming a largely incoherent and inefficient overall transportation system. Travelers today are forced to spend unnecessary time and efforts planning a trip through varying modes of travel each with their own scheduling, pricing, and services; causing many travelers to simply rely on their relatively inefficient and expensive personal automobile. This paper presents a demonstration program system to not only collect and format many different sources of trip planning information, but also combine these independent modes of travel in order to form optimal routes and itineraries of travel. The results of this system show a mean decrease in inter-city travel time of 10 percent and a 25 percent reduction in carbon dioxide emissions over personal automobiles. Additionally, a 55 percent reduction in carbon dioxide emissions is observed for intra-city travel. A conclusion is that current resources are available, if somewhat hidden, to drastically improve point to point transportation in terms of time spent traveling, the cost of travel, and the ecological impact of a trip. Finally, future concepts are considered which could dramatically improve the interoperability and efficiency of the transportation infrastructure.

  17. Integrated Project Management System description. [UMTRAP Project

    SciTech Connect

    Not Available

    1987-03-01

    The Uranium Mill Tailings Remedial Action (UMTRA) Project is a Department of Energy (DOE) designated Major System Acquisition (MSA). To execute and manage the Project mission successfully and to comply with the MSA requirements, the UMTRA Project Office ( Project Office'') has implemented and operates an Integrated Project Management System (IPMS). The Project Office is assisted by the Technical Assistance Contractor's (TAC) Project Integration and Control (PIC) Group in system operation. Each participant, in turn, provides critical input to system operation and reporting requirements. The IPMS provides a uniform structured approach for integrating the work of Project participants. It serves as a tool for planning and control, workload management, performance measurement, and specialized reporting within a standardized format. This system description presents the guidance for its operation. Appendices 1 and 2 contain definitions of commonly used terms and abbreviations and acronyms, respectively. 17 figs., 5 tabs.

  18. Integrated Renewable Hydrogen Utility System

    SciTech Connect

    Proton Energy Systems

    2003-04-01

    Products based on Proton Exchange Membrane (PEM) technology offer a unique solution to today's energy conversion storage needs. PEM products have undergone continual development since the late 1950's for many diverse applications. Rooted in rigorous aerospace applications, this technology is now ''breaking away'' to provide commercial solutions to common power, energy, and industrial gas feedstock problems. Important developments in PEM electrolyzers and various energy conversion devices (e.g. engines and fuel cells) can now be combined to form the basis for a revolutionary energy storage system that provides a much needed link to renewable resources, and offers a credible alternative for off-grid power applications. This technology operates by converting electrical energy into chemical energy in the form of hydrogen as part of a water electrolysis process when excess power is available. When the primary source of power is unavailable, chemical energy is converted into electrical energy through an external combustion heat engine or other energy conversion device. The Phase II portion of this program began in May of 2000. The goal of Phase II of the project was to cost reduce the hydrogen generator as a critical link to having a fully sustainable hydrogen energy system. The overall goal is to enable the link to sustainability by converting excess renewable power into hydrogen and having that hydrogen available for conversion back to power, on demand. Furthermore, the cost of the capability must be less the $1,000 per kW (electrical power into the generator) and allow for a variety of renewable technology inputs. This cost target is based on a production volume of 10,000 units per year. To that end, Proton undertook an aggressive approach to cost reduction activities surrounding the 6kW, 40 standard cubic foot per hour (scfh) HOGEN hydrogen generator. The electrical side of the system targeted a number of areas that included approaches to reduce the cost of the power

  19. GeneCards Version 3: the human gene integrator

    PubMed Central

    Safran, Marilyn; Dalah, Irina; Alexander, Justin; Rosen, Naomi; Iny Stein, Tsippi; Shmoish, Michael; Nativ, Noam; Bahir, Iris; Doniger, Tirza; Krug, Hagit; Sirota-Madi, Alexandra; Olender, Tsviya; Golan, Yaron; Stelzer, Gil; Harel, Arye; Lancet, Doron

    2010-01-01

    GeneCards (www.genecards.org) is a comprehensive, authoritative compendium of annotative information about human genes, widely used for nearly 15 years. Its gene-centric content is automatically mined and integrated from over 80 digital sources, resulting in a web-based deep-linked card for each of >73 000 human gene entries, encompassing the following categories: protein coding, pseudogene, RNA gene, genetic locus, cluster and uncategorized. We now introduce GeneCards Version 3, featuring a speedy and sophisticated search engine and a revamped, technologically enabling infrastructure, catering to the expanding needs of biomedical researchers. A key focus is on gene-set analyses, which leverage GeneCards’ unique wealth of combinatorial annotations. These include the GeneALaCart batch query facility, which tabulates user-selected annotations for multiple genes and GeneDecks, which identifies similar genes with shared annotations, and finds set-shared annotations by descriptor enrichment analysis. Such set-centric features address a host of applications, including microarray data analysis, cross-database annotation mapping and gene-disorder associations for drug targeting. We highlight the new Version 3 database architecture, its multi-faceted search engine, and its semi-automated quality assurance system. Data enhancements include an expanded visualization of gene expression patterns in normal and cancer tissues, an integrated alternative splicing pattern display, and augmented multi-source SNPs and pathways sections. GeneCards now provides direct links to gene-related research reagents such as antibodies, recombinant proteins, DNA clones and inhibitory RNAs and features gene-related drugs and compounds lists. We also portray the GeneCards Inferred Functionality Score annotation landscape tool for scoring a gene’s functional information status. Finally, we delineate examples of applications and collaborations that have benefited from the GeneCards suite

  20. GeneCards Version 3: the human gene integrator.

    PubMed

    Safran, Marilyn; Dalah, Irina; Alexander, Justin; Rosen, Naomi; Iny Stein, Tsippi; Shmoish, Michael; Nativ, Noam; Bahir, Iris; Doniger, Tirza; Krug, Hagit; Sirota-Madi, Alexandra; Olender, Tsviya; Golan, Yaron; Stelzer, Gil; Harel, Arye; Lancet, Doron

    2010-01-01

    GeneCards (www.genecards.org) is a comprehensive, authoritative compendium of annotative information about human genes, widely used for nearly 15 years. Its gene-centric content is automatically mined and integrated from over 80 digital sources, resulting in a web-based deep-linked card for each of >73,000 human gene entries, encompassing the following categories: protein coding, pseudogene, RNA gene, genetic locus, cluster and uncategorized. We now introduce GeneCards Version 3, featuring a speedy and sophisticated search engine and a revamped, technologically enabling infrastructure, catering to the expanding needs of biomedical researchers. A key focus is on gene-set analyses, which leverage GeneCards' unique wealth of combinatorial annotations. These include the GeneALaCart batch query facility, which tabulates user-selected annotations for multiple genes and GeneDecks, which identifies similar genes with shared annotations, and finds set-shared annotations by descriptor enrichment analysis. Such set-centric features address a host of applications, including microarray data analysis, cross-database annotation mapping and gene-disorder associations for drug targeting. We highlight the new Version 3 database architecture, its multi-faceted search engine, and its semi-automated quality assurance system. Data enhancements include an expanded visualization of gene expression patterns in normal and cancer tissues, an integrated alternative splicing pattern display, and augmented multi-source SNPs and pathways sections. GeneCards now provides direct links to gene-related research reagents such as antibodies, recombinant proteins, DNA clones and inhibitory RNAs and features gene-related drugs and compounds lists. We also portray the GeneCards Inferred Functionality Score annotation landscape tool for scoring a gene's functional information status. Finally, we delineate examples of applications and collaborations that have benefited from the GeneCards suite. Database

  1. The integrated Earth System Model Version 1: formulation and functionality

    SciTech Connect

    Collins, William D.; Craig, Anthony P.; Truesdale, John E.; Di Vittorio, Alan; Jones, Andrew D.; Bond-Lamberty, Benjamin; Calvin, Katherine V.; Edmonds, James A.; Kim, Son H.; Thomson, Allison M.; Patel, Pralit L.; Zhou, Yuyu; Mao, Jiafu; Shi, Xiaoying; Thornton, Peter E.; Chini, Louise M.; Hurtt, George C.

    2015-07-23

    The integrated Earth System Model (iESM) has been developed as a new tool for pro- jecting the joint human/climate system. The iESM is based upon coupling an Integrated Assessment Model (IAM) and an Earth System Model (ESM) into a common modeling in- frastructure. IAMs are the primary tool for describing the human–Earth system, including the sources of global greenhouse gases (GHGs) and short-lived species, land use and land cover change, and other resource-related drivers of anthropogenic climate change. ESMs are the primary scientific tools for examining the physical, chemical, and biogeochemical impacts of human-induced changes to the climate system. The iESM project integrates the economic and human dimension modeling of an IAM and a fully coupled ESM within a sin- gle simulation system while maintaining the separability of each model if needed. Both IAM and ESM codes are developed and used by large communities and have been extensively applied in recent national and international climate assessments. By introducing heretofore- omitted feedbacks between natural and societal drivers, we can improve scientific under- standing of the human–Earth system dynamics. Potential applications include studies of the interactions and feedbacks leading to the timing, scale, and geographic distribution of emissions trajectories and other human influences, corresponding climate effects, and the subsequent impacts of a changing climate on human and natural systems. This paper de- scribes the formulation, requirements, implementation, testing, and resulting functionality of the first version of the iESM released to the global climate community.

  2. The integrated Earth system model version 1: formulation and functionality

    DOE PAGESBeta

    Collins, W. D.; Craig, A. P.; Truesdale, J. E.; Di Vittorio, A. V.; Jones, A. D.; Bond-Lamberty, B.; Calvin, K. V.; Edmonds, J. A.; Kim, S. H.; Thomson, A. M.; et al

    2015-07-23

    The integrated Earth system model (iESM) has been developed as a new tool for projecting the joint human/climate system. The iESM is based upon coupling an integrated assessment model (IAM) and an Earth system model (ESM) into a common modeling infrastructure. IAMs are the primary tool for describing the human–Earth system, including the sources of global greenhouse gases (GHGs) and short-lived species (SLS), land use and land cover change (LULCC), and other resource-related drivers of anthropogenic climate change. ESMs are the primary scientific tools for examining the physical, chemical, and biogeochemical impacts of human-induced changes to the climate system. Themore » iESM project integrates the economic and human-dimension modeling of an IAM and a fully coupled ESM within a single simulation system while maintaining the separability of each model if needed. Both IAM and ESM codes are developed and used by large communities and have been extensively applied in recent national and international climate assessments. By introducing heretofore-omitted feedbacks between natural and societal drivers, we can improve scientific understanding of the human–Earth system dynamics. Potential applications include studies of the interactions and feedbacks leading to the timing, scale, and geographic distribution of emissions trajectories and other human influences, corresponding climate effects, and the subsequent impacts of a changing climate on human and natural systems. This paper describes the formulation, requirements, implementation, testing, and resulting functionality of the first version of the iESM released to the global climate community.« less

  3. Integrating homoeopathy in health systems.

    PubMed Central

    Poitevin, B.

    1999-01-01

    Homoeopathy is a therapy which involves many components and three main agents: the patient, with his or her condition and personal characteristics; the medication used, with its composition and manufacturing procedure; and the physician, with his or her approach to treatment and concepts of health. The development of research and evaluation structures, combined with a critical education in the discipline, would help to improve practices and define homoeopathy's potential role in relation to the other therapies, both conventional and unconventional, used in Western health systems. PMID:10083716

  4. Examining human-system interactions: The HSYS (Human SYStem) methodology

    SciTech Connect

    Hill, S.G.; Harbour, J.L.; Sullivan, C.; Hallbert, B.P. )

    1990-01-01

    HSYS is a model-based methodology developed to examine the many factors which influence Human-SYStem interactions. HSYS is built around a linear model of human performance, called the Input-Action model, which describes five sequential steps: Input Detection, Input Understanding, Action Selection, Action Planning, and Action Execution. HSYS is structured in an hierarchical tree which presents a logical structure for examining potential areas where human performance, hardware or other system components are less than adequate. The HSYS tree consists of five major branches which correspond to the five major components of the Input-Action model. Initial validation was begun by studying accident reports via HSYS and identifying sources of error. The validation process has continued with accident investigations in operational settings. 9 refs., 3 figs.

  5. Project ATHENA Creates Surrogate Human Organ Systems

    SciTech Connect

    MacQueen, Luke; Knospel, Fanny; Sherrod, Stacy; Iyer, Rashi

    2015-06-15

    The development of miniature surrogate human organs, coupled with highly sensitive mass spectrometry technologies, could one day revolutionize the way new drugs and toxic agents are studied. “By developing this ‘homo minutus,’ we are stepping beyond the need for animal or Petri dish testing: There are huge benefits in developing drug and toxicity analysis systems that can mimic the response of actual human organs,” said Rashi Iyer, a senior scientist at Los Alamos National Laboratory. ATHENA, the Advanced Tissue-engineered Human Ectypal Network Analyzer project team, is nearing the full integration of four human organ constructs — liver, heart, lung and kidney — each organ component is about the size of a smartphone screen, and the whole ATHENA “body” of interconnected organs will fit neatly on a desk. A new video available on the Los Alamos National Laboratory YouTube channel updates the ATHENA project as it begins to integrate the various organ systems into a single system (link to video here). Some 40 percent of pharmaceuticals fail their clinical trials and there are thousands of chemicals whose effects on humans are simply unknown. Providing a realistic, cost-effective and rapid screening system such as ATHENA with high-throughput capabilities could provide major benefits to the medical field, screening more accurately and offering a greater chance of clinical trial success. ATHENA is funded by the Defense Threat Reduction Agency (DTRA) and is a collaboration of Los Alamos National Laboratory, Harvard University, Vanderbilt University, Charité Universitätsmedizin, Berlin, Germany, CFD Research Corporation, and the University of California San Francisco.

  6. Topical protection of human esophageal mucosal integrity.

    PubMed

    Woodland, P; Batista-Lima, F; Lee, C; Preston, S L; Dettmar, P; Sifrim, D

    2015-06-15

    Patients with nonerosive reflux disease exhibit impaired esophageal mucosal integrity, which may underlie enhanced reflux perception. In vitro topical application of an alginate solution can protect mucosal biopsies against acid-induced changes in transepithelial electrical resistance (TER). We aimed to confirm this finding in a second model using 3D cell cultures and to assess prolonged protection in a biopsy model. We assessed the protective effect of a topically applied alginate solution 1 h after application. 3D cell cultures were grown by using an air-liquid interface and were studied in Ussing chambers. The apical surface was "protected" with 200 μl of either alginate or viscous control or was unprotected. The tissue was exposed to pH 3 + bile acid solution for 30 min and TER change was calculated. Distal esophageal mucosal biopsies were taken from 12 patients and studied in Ussing chambers. The biopsies were coated with either alginate or viscous control solution. The biopsies were then bathed in pH 7.4 solution for 1 h. The luminal chamber solution was replaced with pH 2 solution for 30 min. Percentage changes in TER were recorded. In five biopsies fluorescein-labeled alginate solution was used to allow immunohistological localization of the alginate after 1 h. In the cell culture model, alginate solution protected tissue against acid-induced change in TER. In biopsies, 60 min after protection with alginate solution, the acidic exposure caused a -8.3 ± 2.2% change in TER compared with -25.1 ± 4.5% change after protection with the viscous control (P < 0.05). Labeled alginate could be seen coating the luminal surface in all cases. In vitro, alginate solutions can adhere to the esophageal mucosa for up to 1 h and exert a topical protectant effect. Durable topical protectants can be further explored as first-line/add-on therapies for gastroesophageal reflux disease. PMID:25907692

  7. Distributed Access View Integrated Database (DAVID) system

    NASA Technical Reports Server (NTRS)

    Jacobs, Barry E.

    1991-01-01

    The Distributed Access View Integrated Database (DAVID) System, which was adopted by the Astrophysics Division for their Astrophysics Data System, is a solution to the system heterogeneity problem. The heterogeneous components of the Astrophysics problem is outlined. The Library and Library Consortium levels of the DAVID approach are described. The 'books' and 'kits' level is discussed. The Universal Object Typer Management System level is described. The relation of the DAVID project with the Small Business Innovative Research (SBIR) program is explained.

  8. Air quality data systems integration

    SciTech Connect

    Row, V.K.; Wilson, J.F.

    1998-12-31

    Traditionally, data used for compliance with air quality programs are obtained from various sources within the plant, on site lab, or perhaps from a product movement accounting program. For the most part, the data processing and subsequent calculations and reports were handled individually, thus generating huge spreadsheets and mounds of process data in paper format. The natural reaction to this overwhelming data management problem is to search for an off-the-shelf software package that will hopefully cover all of the plant`s needs for compliance with air quality regulations. Rather than searching for or trying to custom build a single electronic system, the authors suggest using internet browsing software to create links between existing repositories of air quality data and related information.

  9. Human Research Program Integrated Research Plan. Revision C

    NASA Technical Reports Server (NTRS)

    Steinberg, Susan

    2011-01-01

    Crew health and performance are critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) is essential to enabling extended periods of space exploration because it provides knowledge and tools to mitigate risks to human health and performance. Risks include physiological effects from radiation and hypogravity environments, as well as unique challenges in medical support, human factors, and behavioral or psychological factors. The Human Research Program (HRP) delivers human health and performance countermeasures, knowledge, technologies and tools to enable safe, reliable, and productive human space exploration. Without HRP results, NASA will face unknown and unacceptable risks for mission success and post-mission crew health. This Integrated Research Plan (IRP) describes (1) HRP's approach and research activities that are intended to address the needs of human space exploration and serve HRP customers and (2) the method of integration for risk mitigation. The scope of the IRP is limited to the activities that can be conducted with the resources available to the HRP; it does not contain activities that would be performed if additional resources were available. The timescale of human space exploration is envisioned to take many decades. The IRP illustrates the program s research plan through the timescale of early lunar missions of extended duration.

  10. Coal Integrated Gasification Fuel Cell System Study

    SciTech Connect

    Gregory Wotzak; Chellappa Balan; Faress Rahman; Nguyen Minh

    2003-08-01

    The pre-baseline configuration for an Integrated Gasification Fuel Cell (IGFC) system has been developed. This case uses current gasification, clean-up, gas turbine, and bottoming cycle technologies together with projected large planar Solid Oxide Fuel Cell (SOFC) technology. This pre-baseline case will be used as a basis for identifying the critical factors impacting system performance and the major technical challenges in implementing such systems. Top-level system requirements were used as the criteria to evaluate and down select alternative sub-systems. The top choice subsystems were subsequently integrated to form the pre-baseline case. The down-selected pre-baseline case includes a British Gas Lurgi (BGL) gasification and cleanup sub-system integrated with a GE Power Systems 6FA+e gas turbine and the Hybrid Power Generation Systems planar Solid Oxide Fuel Cell (SOFC) sub-system. The overall efficiency of this system is estimated to be 43.0%. The system efficiency of the pre-baseline system provides a benchmark level for further optimization efforts in this program.

  11. Modeling for Integrated Science Management and Resilient Systems Development

    NASA Technical Reports Server (NTRS)

    Shelhamer, M.; Mindock, J.; Lumpkins, S.

    2014-01-01

    Many physiological, environmental, and operational risks exist for crewmembers during spaceflight. An understanding of these risks from an integrated perspective is required to provide effective and efficient mitigations during future exploration missions that typically have stringent limitations on resources available, such as mass, power, and crew time. The Human Research Program (HRP) is in the early stages of developing collaborative modeling approaches for the purposes of managing its science portfolio in an integrated manner to support cross-disciplinary risk mitigation strategies and to enable resilient human and engineered systems in the spaceflight environment. In this talk, we will share ideas being explored from fields such as network science, complexity theory, and system-of-systems modeling. Initial work on tools to support these explorations will be discussed briefly, along with ideas for future efforts.

  12. Fast integral methods for integrated optical systems simulations: a review

    NASA Astrophysics Data System (ADS)

    Kleemann, Bernd H.

    2015-09-01

    -functional profiles, very deep ones, very large ones compared to wavelength, or simple smooth profiles. This integral method with either trigonometric or spline collocation, iterative solver with O(N2) complexity, named IESMP, was significantly improved by an efficient mesh refinement, matrix preconditioning, Ewald summation method, and an exponentially convergent quadrature in 2006 by G. Schmidt and A. Rathsfeld from Weierstrass-Institute (WIAS) Berlin. The so-called modified integral method (MIM) is a modification of the IEM of D. Maystre and has been introduced by L. Goray in 1995. It has been improved for weak convergence problems in 2001 and it was the only commercial available integral method for a long time, known as PCGRATE. All referenced integral methods so far are for in-plane diffraction only, no conical diffraction was possible. The first integral method for gratings in conical mounting was developed and proven under very weak conditions by G. Schmidt (WIAS) in 2010. It works for separated interfaces and for inclusions as well as for interpenetrating interfaces and for a large number of thin and thick layers in the same stable way. This very fast method has then been implemented for parallel processing under Unix and Windows operating systems. This work gives an overview over the most important BIMs for grating diffraction. It starts by presenting the historical evolution of the methods, highlights their advantages and differences, and gives insight into new approaches and their achievements. It addresses future open challenges at the end.

  13. Integration of social information by human groups

    PubMed Central

    Granovskiy, Boris; Gold, Jason M.; Sumpter, David; Goldstone, Robert L.

    2015-01-01

    We consider a situation in which individuals search for accurate decisions without direct feedback on their accuracy but with information about the decisions made by peers in their group. The “wisdom of crowds” hypothesis states that the average judgment of many individuals can give a good estimate of, for example, the outcomes of sporting events and the answers to trivia questions. Two conditions for the application of wisdom of crowds are that estimates should be independent and unbiased. Here, we study how individuals integrate social information when answering trivia questions with answers that range between 0 and 100% (e.g., ‘What percentage of Americans are left-handed?’). We find that, consistent with the wisdom of crowds hypothesis, average performance improves with group size. However, individuals show a consistent bias to produce estimates that are insufficiently extreme. We find that social information provides significant, albeit small, improvement to group performance. Outliers with answers far from the correct answer move towards the position of the group mean. Given that these outliers also tend to be nearer to 50% than do the answers of other group members, this move creates group polarization away from 50%. By looking at individual performance over different questions we find that some people are more likely to be affected by social influence than others. There is also evidence that people differ in their competence in answering questions, but lack of competence is not significantly correlated with willingness to change guesses. We develop a mathematical model based on these results that postulates a cognitive process in which people first decide whether to take into account peer guesses, and if so, to move in the direction of these guesses. The size of the move is proportional to the distance between their own guess and the average guess of the group. This model closely approximates the distribution of guess movements and shows how

  14. Integration of Social Information by Human Groups.

    PubMed

    Granovskiy, Boris; Gold, Jason M; Sumpter, David J T; Goldstone, Robert L

    2015-07-01

    We consider a situation in which individuals search for accurate decisions without direct feedback on their accuracy, but with information about the decisions made by peers in their group. The "wisdom of crowds" hypothesis states that the average judgment of many individuals can give a good estimate of, for example, the outcomes of sporting events and the answers to trivia questions. Two conditions for the application of wisdom of crowds are that estimates should be independent and unbiased. Here, we study how individuals integrate social information when answering trivia questions with answers that range between 0% and 100% (e.g., "What percentage of Americans are left-handed?"). We find that, consistent with the wisdom of crowds hypothesis, average performance improves with group size. However, individuals show a consistent bias to produce estimates that are insufficiently extreme. We find that social information provides significant, albeit small, improvement to group performance. Outliers with answers far from the correct answer move toward the position of the group mean. Given that these outliers also tend to be nearer to 50% than do the answers of other group members, this move creates group polarization away from 50%. By looking at individual performance over different questions we find that some people are more likely to be affected by social influence than others. There is also evidence that people differ in their competence in answering questions, but lack of competence is not significantly correlated with willingness to change guesses. We develop a mathematical model based on these results that postulates a cognitive process in which people first decide whether to take into account peer guesses, and if so, to move in the direction of these guesses. The size of the move is proportional to the distance between their own guess and the average guess of the group. This model closely approximates the distribution of guess movements and shows how outlying

  15. Intelligent Integrated Health Management for a System of Systems

    NASA Technical Reports Server (NTRS)

    Smith, Harvey; Schmalzel, John; Figueroa, Fernando

    2008-01-01

    implemented in the present IIHMS, is to enable automated analysis of physical phenomena in imitation of human reasoning, including the use of qualitative methods. Intelligent integration is said to occur in a system in which all elements are intelligent and can acquire, maintain, and share knowledge and information. In the HDNIE of the present IIHMS, an SoS is represented as being operationally organized in a hierarchical-distributed format. The elements of the SoS are considered to be intelligent in that they determine their own conditions within an integrated scheme that involves consideration of data, information, knowledge bases, and methods that reside in all elements of the system. The conceptual framework of the HDNIE and the methodologies of implementing it enable the flow of information and knowledge among the elements so as to make possible the determination of the condition of each element. The necessary information and knowledge is made available to each affected element at the desired time, satisfying a need to prevent information overload while providing context-sensitive information at the proper level of detail. Provision of high-quality data is a central goal in designing this or any IIHMS. In pursuit of this goal, functionally related sensors are logically assigned to groups denoted processes. An aggregate of processes is considered to form a system. Alternatively or in addition to what has been said thus far, the HDNIE of this IIHMS can be regarded as consisting of a framework containing object models that encapsulate all elements of the system, their individual and relational knowledge bases, generic methods and procedures based on models of the applicable physics, and communication processes (Figure 2). The framework enables implementation of a paradigm inspired by how expert operators monitor the health of systems with the help of (1) DIaK from various sources, (2) software tools that assist in rapid visualization of the condition of the system, (3

  16. System integration of a Telerobotic Demonstration System (TDS) testbed

    NASA Technical Reports Server (NTRS)

    Myers, John K.

    1987-01-01

    The concept for and status of a telerobotic demonstration system testbed that integrates teleoperation and robotics is described. The components of the telerobotic system are described and the ongoing projects are discussed. The system can be divided into two sections: the autonomous subsystems, and the additional interface and support subsystems including teleoperations. The workings of each subsystem by itself and how the subsystems integrate into a complete system is discussed.

  17. Integrated waste and water management system

    NASA Technical Reports Server (NTRS)

    Murray, R. W.; Sauer, R. L.

    1986-01-01

    The performance requirements of the NASA Space Station have prompted a reexamination of a previously developed integrated waste and water management system that used distillation and catalytic oxydation to purify waste water, and microbial digestion and incineration for waste solids disposal. This system successfully operated continuously for 206 days, for a 4-man equivalent load of urine, feces, wash water, condensate, and trash. Attention is given to synergisms that could be established with other life support systems, in the cases of thermal integration, design commonality, and novel technologies.

  18. Reactor power system/spacecraft integration

    NASA Technical Reports Server (NTRS)

    Elms, R. V.

    1985-01-01

    The new national initiative in space reactor technology evaluation and development is strongly tied to mission applications and to spacecraft and space transportation system (STS) compatibility. This paper discusses the power system integration interfaces with potential using spacecraft and the STS, and the impact of these requirements on the design. The integration areas of interest are mechanical, thermal, electrical, attitude control, and mission environments. The mission environments include space vacuum, solar input, heat sink, space radiation, weapons effects, and reactor power system radiation environments. The natural, reactor, and weapons effects radiation must be evaluated and combined to define the design requirements for spacecraft electronic equipment.

  19. Space Station Information System integrated communications concept

    NASA Technical Reports Server (NTRS)

    Muratore, J.; Bigham, J.; Whitelaw, V.; Marker, W.

    1987-01-01

    This paper presents a model for integrated communications within the Space Station Information System (SSIS). The SSIS is generally defined as the integrated set of space and ground information systems and networks which will provide required data services to the Space Station flight crew, ground operations personnel, and customer communities. This model is based on the International Standards Organization (ISO) layered model for Open Systems Interconnection (OSI). The requirements used to develop the model are presented, and the various elements of the model described.

  20. Engineering the System and Technical Integration

    NASA Technical Reports Server (NTRS)

    Blair, J. C.; Ryan, R. S.; Schutzenhofer, L. A.

    2011-01-01

    Approximately 80% of the problems encountered in aerospace systems have been due to a breakdown in technical integration and/or systems engineering. One of the major challenges we face in designing, building, and operating space systems is: how is adequate integration achieved for the systems various functions, parts, and infrastructure? This Contractor Report (CR) deals with part of the problem of how we engineer the total system in order to achieve the best balanced design. We will discuss a key aspect of this question - the principle of Technical Integration and its components, along with management and decision making. The CR will first provide an introduction with a discussion of the Challenges in Space System Design and meeting the challenges. Next is an overview of Engineering the System including Technical Integration. Engineering the System is expanded to include key aspects of the Design Process, Lifecycle Considerations, etc. The basic information and figures used in this CR were presented in a NASA training program for Program and Project Managers Development (PPMD) in classes at Georgia Tech and at Marshall Space Flight Center (MSFC). Many of the principles and illustrations are extracted from the courses we teach for MSFC.

  1. Develop Education Systems that Integrate All Levels

    ERIC Educational Resources Information Center

    Kiker, Jason

    2007-01-01

    During the last few years, the development of seamless education systems to promote students' postsecondary success has been discussed by policymakers at the local, state and federal levels as well as reform-minded individuals. Florida, Washington, Iowa, Georgia and California either have statewide integrated systems or are moving quickly toward…

  2. CTBT integrated verification system evaluation model supplement

    SciTech Connect

    EDENBURN,MICHAEL W.; BUNTING,MARCUS; PAYNE JR.,ARTHUR C.; TROST,LAWRENCE C.

    2000-03-02

    Sandia National Laboratories has developed a computer based model called IVSEM (Integrated Verification System Evaluation Model) to estimate the performance of a nuclear detonation monitoring system. The IVSEM project was initiated in June 1994, by Sandia's Monitoring Systems and Technology Center and has been funded by the U.S. Department of Energy's Office of Nonproliferation and National Security (DOE/NN). IVSEM is a simple, ''top-level,'' modeling tool which estimates the performance of a Comprehensive Nuclear Test Ban Treaty (CTBT) monitoring system and can help explore the impact of various sensor system concepts and technology advancements on CTBT monitoring. One of IVSEM's unique features is that it integrates results from the various CTBT sensor technologies (seismic, in sound, radionuclide, and hydroacoustic) and allows the user to investigate synergy among the technologies. Specifically, IVSEM estimates the detection effectiveness (probability of detection), location accuracy, and identification capability of the integrated system and of each technology subsystem individually. The model attempts to accurately estimate the monitoring system's performance at medium interfaces (air-land, air-water) and for some evasive testing methods such as seismic decoupling. The original IVSEM report, CTBT Integrated Verification System Evaluation Model, SAND97-25 18, described version 1.2 of IVSEM. This report describes the changes made to IVSEM version 1.2 and the addition of identification capability estimates that have been incorporated into IVSEM version 2.0.

  3. Integrated Postsecondary Education Data System (IPEDS).

    ERIC Educational Resources Information Center

    Broyles, Susan

    This booklet introduces the Integrated Postsecondary Education Data System (IPEDS) surveys administered by the Bureau of the Census for the National Center for Education Statistics (NCES). It contains a general description of the survey forms and their uses. IPEDS is a system of surveys designed to collect data from all providers of postsecondary…

  4. System-Level Integration of Mass Memory

    NASA Technical Reports Server (NTRS)

    Cox, Brian; Mellstrom, Jeffrey; Wysocky, Terry

    2008-01-01

    A report discusses integrating multiple memory modules on the high-speed serial interconnect (IEEE 1393) that is used by a spacecraft?s inter-module communications in order to ease data congestion and provide for a scalable, strong, flexible system that can meet new system-level mass memory requirements.

  5. Human System Risk Management for Space Flight

    NASA Technical Reports Server (NTRS)

    Davis, Jeffrey

    2015-01-01

    2004 of evaluating the tolerance limits and safe operating bands called for in the Bioastronautics Strategy. Over the next several years, the concept of the "operating bands" were turned into Space Flight Human System Standards (SFHSS), developed by the technical resources of the SLSD at the NASA Johnson Space Center (JSC). These standards were developed and reviewed at the SLSD and then presented to the OCHMO for acceptance. The first set of standards was published in 2007 as the NASA-STD-3001, Volume 1, Crew Health that elaborated standards for several physiological areas such as cardiovascular, musculoskeletal, radiation exposure and nutrition. Volume 2, Human Factors, Habitability and Human Health was published in 2011, along with development guidance in the Human Integration Design Handbook (HIDH). Taken together, the SFHSS Volumes 1 and 2, and the HIDH replaced the NASA-STD-3000 with new standards and revisions of the older document. Three other changes were also taking place that facilitated the development of the human system risk management approach. In 2005, the life sciences research and development portfolio underwent a comprehensive review through the Exploration Systems Architecture Study (ESAS) that resulted in the reformulation of the Bioastronautics Program into Human Research Program (HRP) that was focused on appropriate mitigation results for high priority human health risks. The baseline HRP budget was established in August 2005. In addition, the OCHMO formulated the Health and Medical Technical Authority (HMTA) in 2006 that established the position of the Chief Medical Officer (CMO) at the NASA JSC along with other key technical disciplines, and the OCHMO became the responsible office for the SFHSS as noted above. The final change was the establishment in 2008 of the Human System Risk Board (HSRB), chaired by the CMO with representation from the HRP, SLSD management and technical experts. The HSRB then began to review all human system risks

  6. Bay integrated power system control and diagnostics

    SciTech Connect

    Beierl, O.

    1996-03-01

    The paper presents new concepts for control and diagnostic systems for high voltage switchgear (123-kV and above). Air insulated and gas insulated (SF6) switchgear is considered. The new aspect is the integration of monitoring and diagnostic concepts in digital control and protection systems. Communication concepts for sensors and actuators with digital process busses at bay level are discussed. The paper covers integration concepts for circuit breaker monitoring (AIS, GIS) and for GIS the integration of on-line partial discharge measurement, on-line arc detection and on-line monitoring of the gas conditions. Finally, the advantages, disadvantages and the applicability of integrated diagnostic and control concepts are discussed by means of technical and commercial aspects.

  7. Earth System Science: An Integrated Approach.

    ERIC Educational Resources Information Center

    Environment, 2001

    2001-01-01

    Details how an understanding of the role played by human activities in global environmental change has emerged. Presents information about the earth system provided by research programs. Speculates about the direction of future research. (DDR)

  8. Flight testing an integrated synthetic vision system

    NASA Astrophysics Data System (ADS)

    Kramer, Lynda J.; Arthur, Jarvis J., III; Bailey, Randall E.; Prinzel, Lawrence J., III

    2005-05-01

    NASA's Synthetic Vision Systems (SVS) project is developing technologies with practical applications to eliminate low visibility conditions as a causal factor to civil aircraft accidents while replicating the operational benefits of clear day flight operations, regardless of the actual outside visibility condition. A major thrust of the SVS project involves the development/demonstration of affordable, certifiable display configurations that provide intuitive out-the-window terrain and obstacle information with advanced pathway guidance for transport aircraft. The SVS concept being developed at NASA encompasses the integration of tactical and strategic Synthetic Vision Display Concepts (SVDC) with Runway Incursion Prevention System (RIPS) alerting and display concepts, real-time terrain database integrity monitoring equipment (DIME), and Enhanced Vision Systems (EVS) and/or improved Weather Radar for real-time object detection and database integrity monitoring. A flight test evaluation was jointly conducted (in July and August 2004) by NASA Langley Research Center and an industry partner team under NASA's Aviation Safety and Security, Synthetic Vision System project. A Gulfstream G-V aircraft was flown over a 3-week period in the Reno/Tahoe International Airport (NV) local area and an additional 3-week period in the Wallops Flight Facility (VA) local area to evaluate integrated Synthetic Vision System concepts. The enabling technologies (RIPS, EVS and DIME) were integrated into the larger SVS concept design. This paper presents experimental methods and the high level results of this flight test.

  9. Flight Testing an Integrated Synthetic Vision System

    NASA Technical Reports Server (NTRS)

    Kramer, Lynda J.; Arthur, Jarvis J., III; Bailey, Randall E.; Prinzel, Lawrence J., III

    2005-01-01

    NASA's Synthetic Vision Systems (SVS) project is developing technologies with practical applications to eliminate low visibility conditions as a causal factor to civil aircraft accidents while replicating the operational benefits of clear day flight operations, regardless of the actual outside visibility condition. A major thrust of the SVS project involves the development/demonstration of affordable, certifiable display configurations that provide intuitive out-the-window terrain and obstacle information with advanced pathway guidance for transport aircraft. The SVS concept being developed at NASA encompasses the integration of tactical and strategic Synthetic Vision Display Concepts (SVDC) with Runway Incursion Prevention System (RIPS) alerting and display concepts, real-time terrain database integrity monitoring equipment (DIME), and Enhanced Vision Systems (EVS) and/or improved Weather Radar for real-time object detection and database integrity monitoring. A flight test evaluation was jointly conducted (in July and August 2004) by NASA Langley Research Center and an industry partner team under NASA's Aviation Safety and Security, Synthetic Vision System project. A Gulfstream GV aircraft was flown over a 3-week period in the Reno/Tahoe International Airport (NV) local area and an additional 3-week period in the Wallops Flight Facility (VA) local area to evaluate integrated Synthetic Vision System concepts. The enabling technologies (RIPS, EVS and DIME) were integrated into the larger SVS concept design. This paper presents experimental methods and the high level results of this flight test.

  10. Rocket Testing and Integrated System Health Management

    NASA Technical Reports Server (NTRS)

    Figueroa, Fernando; Schmalzel, John

    2005-01-01

    Integrated System Health Management (ISHM) describes a set of system capabilities that in aggregate perform: determination of condition for each system element, detection of anomalies, diagnosis of causes for anomalies, and prognostics for future anomalies and system behavior. The ISHM should also provide operators with situational awareness of the system by integrating contextual and timely data, information, and knowledge (DIaK) as needed. ISHM capabilities can be implemented using a variety of technologies and tools. This chapter provides an overview of ISHM contributing technologies and describes in further detail a novel implementation architecture along with associated taxonomy, ontology, and standards. The operational ISHM testbed is based on a subsystem of a rocket engine test stand. Such test stands contain many elements that are common to manufacturing systems, and thereby serve to illustrate the potential benefits and methodologies of the ISHM approach for intelligent manufacturing.

  11. Exploring the Decision Landscape: Integration of Human and Natural Systems Using the Driver-Pressure-State-Impact-Response Framework and Dynamic Web Application

    EPA Science Inventory

    Making decisions to increase community or regional sustainability requires a comprehensive understanding of the linkages between environmental, social, and economic systems. We present a visualization tool that can improve decision processes and improve interdisciplinary research...

  12. Human Services Course Delivery Systems.

    ERIC Educational Resources Information Center

    Soong, Robert K.; And Others

    This paper deals with various teaching methods and techniques currently is use in junior colleges in the Chicago area including traditional as well as innovative methods. The basic assumption is that teaching and learning are both essential aspects of the same system. The human services field is defined as encompassing the basic area of social…

  13. Integrating Systems Thinking Into Nursing Education.

    PubMed

    Phillips, Janet M; Stalter, Ann M

    2016-09-01

    A critical need exists for nursing leadership in current complex health care settings. Systems thinking can be incorporated into nursing education at all levels by using evidence-based principles in education. Teaching tips are provided using a systems awareness model to guide nurse educators in the assessment and integration of systems thinking and engaging learners in interprofessional education and practice. J Contin Educ Nurs. 2016;47(9):395-397. PMID:27580505

  14. The Habitat Demonstration Unit System Integration

    NASA Technical Reports Server (NTRS)

    Gill, Tracy R.; Kennedy, Kriss J.; Tri, Terry O.; Howe, Alan S.

    2010-01-01

    The Lunar Surface System Habitat Demonstration Unit (HDU) will require a project team to integrate a variety of contributions from National Aeronautics and Space Administration (NASA) centers and potential outside collaborators and poses a challenge in integrating these disparate efforts into a cohesive architecture. To accomplish the development of the first version of the HDU, the Pressurized Excursion Module (PEM), from conception in June 2009 to rollout for operations in July 2010, the HDU project team is using several strategies to mitigate risks and bring the separate efforts together. First, a set of design standards is being developed to define the interfaces between the various systems of PEM and to the payloads, such as the Geology Laboratory, that those systems will support. Scheduled activities such as early fit-checks and the utilization of a habitat avionics test bed prior to equipment installation into HDU PEM are planned to facilitate the integration process. A coordinated effort to establish simplified Computer Aided Design (CAD) standards and the utilization of a modeling and simulation systems will aid in design and integration concept development. Finally, decision processes on the shell development including the assembly sequence and the transportation have been fleshed out early on HDU design to maximize the efficiency of both integration and field operations.

  15. Multiloop integral system test (MIST): Final report

    SciTech Connect

    Gloudemans, J.R. . Nuclear Power Div.)

    1991-04-01

    The Multiloop Integral System Test (MIST) is part of a multiphase program started in 1983 to address small-break loss-of-coolant accidents (SBLOCAs) specific to Babcock and Wilcox designed plants. MIST is sponsored by the US Nuclear Regulatory Commission, the Babcock Wilcox Owners Group, the Electric Power Research Institute, and Babcock and Wilcox. The unique features of the Babcock and Wilcox design, specifically the hot leg U-bends and steam generators, prevented the use of existing integral system data or existing integral facilities to address the thermal-hydraulic SBLOCA questions. MIST was specifically designed and constructed for this program, and an existing facility -- the Once Through Integral System (OTIS) -- was also used. Data from MIST and OTIS are used to benchmark the adequacy of system codes, such as RELAP5 and TRAC, for predicting abnormal plant transients. The MIST program is reported in 11 volumes. Volumes 2 through 8 pertain to groups of Phase 3 tests by type; Volume 9 presents inter-group comparisons; Volume 10 provides comparisons between the RELAP5/MOD2 calculations and MIST observations, and Volume 11 (with addendum) presents the later Phase 4 tests. This is Volume 1 of the MIST final report, a summary of the entire MIST program. Major topics include, Test Advisory Group (TAG) issues, facility scaling and design, test matrix, observations, comparison of RELAP5 calculations to MIST observations, and MIST versus the TAG issues. MIST generated consistent integral-system data covering a wide range of transient interactions. MIST provided insight into integral system behavior and assisted the code effort. The MIST observations addressed each of the TAG issues. 11 refs., 29 figs., 9 tabs.

  16. Vitrification Facility integrated system performance testing report

    SciTech Connect

    Elliott, D.

    1997-05-01

    This report provides a summary of component and system performance testing associated with the Vitrification Facility (VF) following construction turnover. The VF at the West Valley Demonstration Project (WVDP) was designed to convert stored radioactive waste into a stable glass form for eventual disposal in a federal repository. Following an initial Functional and Checkout Testing of Systems (FACTS) Program and subsequent conversion of test stand equipment into the final VF, a testing program was executed to demonstrate successful performance of the components, subsystems, and systems that make up the vitrification process. Systems were started up and brought on line as construction was completed, until integrated system operation could be demonstrated to produce borosilicate glass using nonradioactive waste simulant. Integrated system testing and operation culminated with a successful Operational Readiness Review (ORR) and Department of Energy (DOE) approval to initiate vitrification of high-level waste (HLW) on June 19, 1996. Performance and integrated operational test runs conducted during the test program provided a means for critical examination, observation, and evaluation of the vitrification system. Test data taken for each Test Instruction Procedure (TIP) was used to evaluate component performance against system design and acceptance criteria, while test observations were used to correct, modify, or improve system operation. This process was critical in establishing operating conditions for the entire vitrification process.

  17. Human Factors Considerations in System Design

    NASA Technical Reports Server (NTRS)

    Mitchell, C. M. (Editor); Vanbalen, P. M. (Editor); Moe, K. L. (Editor)

    1983-01-01

    Human factors considerations in systems design was examined. Human factors in automated command and control, in the efficiency of the human computer interface and system effectiveness are outlined. The following topics are discussed: human factors aspects of control room design; design of interactive systems; human computer dialogue, interaction tasks and techniques; guidelines on ergonomic aspects of control rooms and highly automated environments; system engineering for control by humans; conceptual models of information processing; information display and interaction in real time environments.

  18. Integrating human impacts and ecological integrity into a risk-based protocol for conservation planning

    USGS Publications Warehouse

    Mattson, K.M.; Angermeier, P.L.

    2007-01-01

    Conservation planning aims to protect biodiversity by sustainng the natural physical, chemical, and biological processes within representative ecosystems. Often data to measure these components are inadequate or unavailable. The impact of human activities on ecosystem processes complicates integrity assessments and might alter ecosystem organization at multiple spatial scales. Freshwater conservation targets, such as populations and communities, are influenced by both intrinsic aquatic properties and the surrounding landscape, and locally collected data might not accurately reflect potential impacts. We suggest that changes in five major biotic drivers-energy sources, physical habitat, flow regime, water quality, and biotic interactions-might be used as surrogates to inform conservation planners of the ecological integrity of freshwater ecosystems. Threats to freshwater systems might be evaluated based on their impact to these drivers to provide an overview of potential risk to conservation targets. We developed a risk-based protocol, the Ecological Risk Index (ERI), to identify watersheds with least/most risk to conservation targets. Our protocol combines risk-based components, specifically the frequency and severity of human-induced stressors, with biotic drivers and mappable land- and water-use data to provide a summary of relative risk to watersheds. We illustrate application of our protocol with a case study of the upper Tennessee River basin, USA. Differences in risk patterns among the major drainages in the basin reflect dominant land uses, such as mining and agriculture. A principal components analysis showed that localized, moderately severe threats accounted for most of the threat composition differences among our watersheds. We also found that the relative importance of threats is sensitive to the spatial grain of the analysis. Our case study demonstrates that the ERI is useful for evaluating the frequency and severity of ecosystemwide risk, which can

  19. Integrating Action Theory and Human Agency in Career Development.

    ERIC Educational Resources Information Center

    Chen, Charles P.

    2002-01-01

    Paper discusses and analyzes the correlation between action theory and the notion of human agency in a life career development context. Theoretical and research background of the two perspectives are discussed. Connections between the two perspectives are identified. Career counseling implications that enhance integration of individuals' action…

  20. The Astonishing Curriculum: Integrating Science and Humanities through Language.

    ERIC Educational Resources Information Center

    Tchudi, Stephen, Ed.

    This book probes the possibilities of interdisciplinary learning and integrated curriculum through the structuring and expressive powers of language. The 15 essays in the book explore the issues of bridging the gap between the two cultures of science and humanities, demystifying science for learners, teaching students to construct and explain…

  1. INTEGRATED HUMAN EXPOSURE SOURCE-TO-DOSE MODELING

    EPA Science Inventory

    The NERL human exposure research program is designed to provide a sound, scientifically-based approach to understanding how people are actually exposed to pollutants and the factors and pathways influencing exposure and dose. This research project serves to integrate and incorpo...

  2. How Do Volcanoes Affect Human Life? Integrated Unit.

    ERIC Educational Resources Information Center

    Dayton, Rebecca; Edwards, Carrie; Sisler, Michelle

    This packet contains a unit on teaching about volcanoes. The following question is addressed: How do volcanoes affect human life? The unit covers approximately three weeks of instruction and strives to present volcanoes in an holistic form. The five subject areas of art, language arts, mathematics, science, and social studies are integrated into…

  3. Driving Performance Improvements by Integrating Competencies with Human Resource Practices

    ERIC Educational Resources Information Center

    Lee, Jin Gu; Park, Yongho; Yang, Gi Hun

    2010-01-01

    This study explores the issues in the development and application of a competency model and provides implications for more precise integration of competencies into human resource (HR) functions driving performance improvement. This research is based on a case study from a Korean consumer corporation. This study employed document reviews,…

  4. Photonic crystal technology for terahertz system integration

    NASA Astrophysics Data System (ADS)

    Fujita, Masayuki; Nagatsuma, Tadao

    2016-04-01

    Developing terahertz integration technology is essential for practical use of terahertz electromagnetic waves (0.1-10 THz) in various applications including broadband wireless communication, spectroscopic sensing, and nondestructive imaging. In this paper, we present our recent challenges towards terahertz system integration based on photonic crystal technology such as the development of terahertz transceivers. We use photonic-crystal slabs consisting of a twodimensional lattice of air holes formed in a silicon slab to develop low loss compact terahertz components in planar structures. The demonstration of ultralow loss (< 0.1 dB/cm) waveguides and integrated transceiver devices in the 0.3 THz band shows the potential for the application of photonic crystals to terahertz integration technology. Improving the coupling efficiency between the photonic crystal waveguide and resonant tunneling diode is important to take full advantage of the ultralow loss photonic crystal waveguides.

  5. CTBT Integrated Verification System Evaluation Model

    SciTech Connect

    Edenburn, M.W.; Bunting, M.L.; Payne, A.C. Jr.

    1997-10-01

    Sandia National Laboratories has developed a computer based model called IVSEM (Integrated Verification System Evaluation Model) to estimate the performance of a nuclear detonation monitoring system. The IVSEM project was initiated in June 1994, by Sandia`s Monitoring Systems and Technology Center and has been funded by the US Department of Energy`s Office of Nonproliferation and National Security (DOE/NN). IVSEM is a simple, top-level, modeling tool which estimates the performance of a Comprehensive Nuclear Test Ban Treaty (CTBT) monitoring system and can help explore the impact of various sensor system concepts and technology advancements on CTBT monitoring. One of IVSEM`s unique features is that it integrates results from the various CTBT sensor technologies (seismic, infrasound, radionuclide, and hydroacoustic) and allows the user to investigate synergy among the technologies. Specifically, IVSEM estimates the detection effectiveness (probability of detection) and location accuracy of the integrated system and of each technology subsystem individually. The model attempts to accurately estimate the monitoring system`s performance at medium interfaces (air-land, air-water) and for some evasive testing methods such as seismic decoupling. This report describes version 1.2 of IVSEM.

  6. Which coordinate system for modelling path integration?

    PubMed

    Vickerstaff, Robert J; Cheung, Allen

    2010-03-21

    Path integration is a navigation strategy widely observed in nature where an animal maintains a running estimate, called the home vector, of its location during an excursion. Evidence suggests it is both ancient and ubiquitous in nature, and has been studied for over a century. In that time, canonical and neural network models have flourished, based on a wide range of assumptions, justifications and supporting data. Despite the importance of the phenomenon, consensus and unifying principles appear lacking. A fundamental issue is the neural representation of space needed for biological path integration. This paper presents a scheme to classify path integration systems on the basis of the way the home vector records and updates the spatial relationship between the animal and its home location. Four extended classes of coordinate systems are used to unify and review both canonical and neural network models of path integration, from the arthropod and mammalian literature. This scheme demonstrates analytical equivalence between models which may otherwise appear unrelated, and distinguishes between models which may superficially appear similar. A thorough analysis is carried out of the equational forms of important facets of path integration including updating, steering, searching and systematic errors, using each of the four coordinate systems. The type of available directional cue, namely allothetic or idiothetic, is also considered. It is shown that on balance, the class of home vectors which includes the geocentric Cartesian coordinate system, appears to be the most robust for biological systems. A key conclusion is that deducing computational structure from behavioural data alone will be difficult or impossible, at least in the absence of an analysis of random errors. Consequently it is likely that further theoretical insights into path integration will require an in-depth study of the effect of noise on the four classes of home vectors. PMID:19962387

  7. Multiloop Integral System Test (MIST): Final report

    SciTech Connect

    Klingenfus, J.A.; Parece, M.V.

    1989-12-01

    The multiloop integral system test (MIST) facility is part of a multiphase program started in 1983 to address small-break loss-of- coolant accidents (SBLOCAs) specific to Babcock Wilcox (B W) designed plants. MIST is sponsored by the US Nuclear Regulatory Commission, the B W Owners group, the Electric Power Research Institute, and B W. The unique features of the B W design, specifically the hot leg U-bends and steam generators, prevented the use of existing integral system data or existing integral system facilities to address the thermal-hydraulic SBLOCA questions. MIST and two other supporting facilities were specifically designed and constructed for this program, and an existing facility -- the once-through integral system (OTIS) -- was also used. Data from MIST and the other facilities will be used to benchmark the adequacy of system codes, such a RELAP5/MOD2 and TRAC-PF1, for predicting abnormal plant transients. The MIST program included funding for seven individual RELAP pre- and post-test predictions. The comparisons against data and final conclusions are the subject of this volume of the MIST Final Report. 15 refs., 227 figs., 17 tabs.

  8. MIST (multiloop integral system test) final report

    SciTech Connect

    Klingenfus, J.A.; Parece, M.V. . Engineering and Plant Services Div.)

    1990-04-01

    The multiloop integral system test (MIST) facility is part of a multiphase program started in 1983 to address small-break loss-of- coolant accidents (SBLOCAs) specific to Babcock Wilcox (B W) designed plants. MIST is sponsored by the US Nuclear Regulatory Commission, the B W Owners Group, the Electric Power Research Institute, and B W. The unique features of the B W design, specifically the hot leg U-bends and steam generators, prevented the use of existing integral system data or existing integral system facilities to address the thermal-hydraulic SBLOCA questions. MIST and two other supporting facilities were specifically designed and constructed for this program, and an existing facility --- the once-through integral system (OTIS) --- was also used. Data from MIST and the other facilities will be used to benchmark the adequacy of system codes, such as RELAP5/MOD2 and TRAC-PF1, for predicting abnormal plant transients. The MIST program included funding for seven individual RELAP pre- and post-test predictions. The comparisons against data and final conclusions are the subject of this volume of the MIST Final Report. 15 refs., 227 figs., 18 tabs.

  9. Outcome mapping for health system integration

    PubMed Central

    Tsasis, Peter; Evans, Jenna M; Forrest, David; Jones, Richard Keith

    2013-01-01

    Health systems around the world are implementing integrated care strategies to improve quality, reduce or maintain costs, and improve the patient experience. Yet few practical tools exist to aid leaders and managers in building the prerequisites to integrated care, namely a shared vision, clear roles and responsibilities, and a common understanding of how the vision will be realized. Outcome mapping may facilitate stakeholder alignment on the vision, roles, and processes of integrated care delivery via participative and focused dialogue among diverse stakeholders on desired outcomes and enabling actions. In this paper, we describe an outcome-mapping exercise we conducted at a Local Health Integration Network in Ontario, Canada, using consensus development conferences. Our preliminary findings suggest that outcome mapping may help stakeholders make sense of a complex system and foster collaborative capital, a resource that can support information sharing, trust, and coordinated change toward integration across organizational and professional boundaries. Drawing from the theoretical perspectives of complex adaptive systems and collaborative capital, we also outline recommendations for future outcome-mapping exercises. In particular, we emphasize the potential for outcome mapping to be used as a tool not only for identifying and linking strategic outcomes and actions, but also for studying the boundaries, gaps, and ties that characterize social networks across the continuum of care. PMID:23526058

  10. Outcome mapping for health system integration.

    PubMed

    Tsasis, Peter; Evans, Jenna M; Forrest, David; Jones, Richard Keith

    2013-01-01

    Health systems around the world are implementing integrated care strategies to improve quality, reduce or maintain costs, and improve the patient experience. Yet few practical tools exist to aid leaders and managers in building the prerequisites to integrated care, namely a shared vision, clear roles and responsibilities, and a common understanding of how the vision will be realized. Outcome mapping may facilitate stakeholder alignment on the vision, roles, and processes of integrated care delivery via participative and focused dialogue among diverse stakeholders on desired outcomes and enabling actions. In this paper, we describe an outcome-mapping exercise we conducted at a Local Health Integration Network in Ontario, Canada, using consensus development conferences. Our preliminary findings suggest that outcome mapping may help stakeholders make sense of a complex system and foster collaborative capital, a resource that can support information sharing, trust, and coordinated change toward integration across organizational and professional boundaries. Drawing from the theoretical perspectives of complex adaptive systems and collaborative capital, we also outline recommendations for future outcome-mapping exercises. In particular, we emphasize the potential for outcome mapping to be used as a tool not only for identifying and linking strategic outcomes and actions, but also for studying the boundaries, gaps, and ties that characterize social networks across the continuum of care. PMID:23526058

  11. An integrative transcriptomic atlas of organogenesis in human embryos.

    PubMed

    Gerrard, Dave T; Berry, Andrew A; Jennings, Rachel E; Piper Hanley, Karen; Bobola, Nicoletta; Hanley, Neil A

    2016-01-01

    Human organogenesis is when severe developmental abnormalities commonly originate. However, understanding this critical embryonic phase has relied upon inference from patient phenotypes and assumptions from in vitro stem cell models and non-human vertebrates. We report an integrated transcriptomic atlas of human organogenesis. By lineage-guided principal components analysis, we uncover novel relatedness of particular developmental genes across different organs and tissues and identified unique transcriptional codes which correctly predicted the cause of many congenital disorders. By inference, our model pinpoints co-enriched genes as new causes of developmental disorders such as cleft palate and congenital heart disease. The data revealed more than 6000 novel transcripts, over 90% of which fulfil criteria as long non-coding RNAs correlated with the protein-coding genome over megabase distances. Taken together, we have uncovered cryptic transcriptional programs used by the human embryo and established a new resource for the molecular understanding of human organogenesis and its associated disorders. PMID:27557446

  12. Humane Letters: Notes on the Concept of Integrity and the Meanings of Humanism

    ERIC Educational Resources Information Center

    Higgins, Chris

    2009-01-01

    In this article, the author calls for an analysis of integrity and contends that attempting to describe wholeness precisely and incisively is not necessarily a contradiction in terms. The author makes some distinctions about integrity using two moves, one inspired by Plato, and one by Aristotle. The author uses the phrase "humane letters" to name…

  13. Integrating Medical Humanities into a Pharmaceutical Care Seminar on Dementia

    PubMed Central

    2013-01-01

    Objective. To design, integrate, and assess the effectiveness of a medical humanities teaching module that focuses on pharmaceutical care for dementia patients. Design. Visual and textual dementia narratives were presented using a combination of teacher and learner-centered approaches with the aim being to highlight patients’ and caregivers’ needs for empathy and counselling. Assessment. As gauged from pre- and post-experience questionnaires, students highly rated this approach to teaching medical humanities. In-class presentations demonstrated students’ increased sensitivity to patient and caregiver needs, while objective learning outcomes demonstrated students’ increased knowledge and awareness. Conclusions. Pharmacy students were open to and successfully learned from reading and discussing patient and caregiver narratives, which furthers the discussion on the value of integrating the medical humanities into the curricula of pharmacy and other health sciences. PMID:23459365

  14. Integrating medical humanities into a pharmaceutical care seminar on dementia.

    PubMed

    Zimmermann, Martina

    2013-02-12

    Objective. To design, integrate, and assess the effectiveness of a medical humanities teaching module that focuses on pharmaceutical care for dementia patients.Design. Visual and textual dementia narratives were presented using a combination of teacher and learner-centered approaches with the aim being to highlight patients' and caregivers' needs for empathy and counselling.Assessment. As gauged from pre- and post-experience questionnaires, students highly rated this approach to teaching medical humanities. In-class presentations demonstrated students' increased sensitivity to patient and caregiver needs, while objective learning outcomes demonstrated students' increased knowledge and awareness.Conclusions. Pharmacy students were open to and successfully learned from reading and discussing patient and caregiver narratives, which furthers the discussion on the value of integrating the medical humanities into the curricula of pharmacy and other health sciences. PMID:23459365

  15. Microdisplay modules for enhanced system integration

    NASA Astrophysics Data System (ADS)

    Edwards, Tim; Hogan, Tim

    2013-06-01

    Kopin's recently introduced low-power "Jewel Module" family of plug-and-play integrated AMLCD microdisplay modules are fully-tested, off-the-shelf assemblies that can be easily integrated into customer products without the need for an expensive application-specific development. The "Jewel Module" is the culmination of many years of technology advancement that has reduced the size and power for all of the elements of the display system: microdisplay, LED backlight, display driver ASIC, video FPGA, heater and display controller. This paper presents the performance characteristics of both current and planned modules with display resolutions from 640x480 to 1280x1024 as well as development roadmap. Applications of the "Ruby Module" with SVGA microdisplay are described with examples of its integration into display system products.

  16. Perspectives for integrating human and environmental exposure assessments.

    PubMed

    Ciffroy, P; Péry, A R R; Roth, N

    2016-10-15

    Integrated Risk Assessment (IRA) has been defined by the EU FP7 HEROIC Coordination action as "the mutual exploitation of Environmental Risk Assessment for Human Health Risk Assessment and vice versa in order to coherently and more efficiently characterize an overall risk to humans and the environment for better informing the risk analysis process" (Wilks et al., 2015). Since exposure assessment and hazard characterization are the pillars of risk assessment, integrating Environmental Exposure assessment (EEA) and Human Exposure assessment (HEA) is a major component of an IRA framework. EEA and HEA typically pursue different targets, protection goals and timeframe. However, human and wildlife species also share the same environment and they similarly inhale air and ingest water and food through often similar overlapping pathways of exposure. Fate models used in EEA and HEA to predict the chemicals distribution among physical and biological media are essentially based on common properties of chemicals, and internal concentration estimations are largely based on inter-species (i.e. biota-to-human) extrapolations. Also, both EEA and HEA are challenged by increasing scientific complexity and resources constraints. Altogether, these points create the need for a better exploitation of all currently existing data, experimental approaches and modeling tools and it is assumed that a more integrated approach of both EEA and HEA may be part of the solution. Based on the outcome of an Expert Workshop on Extrapolations in Integrated Exposure Assessment organized by the HEROIC project in January 2014, this paper identifies perspectives and recommendations to better harmonize and extrapolate exposure assessment data, models and methods between Human Health and Environmental Risk Assessments to support the further development and promotion of the concept of IRA. Ultimately, these recommendations may feed into guidance showing when and how to apply IRA in the regulatory decision

  17. NIF Integrated Computer Controls System Description

    SciTech Connect

    VanArsdall, P.

    1998-01-26

    This System Description introduces the NIF Integrated Computer Control System (ICCS). The architecture is sufficiently abstract to allow the construction of many similar applications from a common framework. As discussed below, over twenty software applications derived from the framework comprise the NIF control system. This document lays the essential foundation for understanding the ICCS architecture. The NIF design effort is motivated by the magnitude of the task. Figure 1 shows a cut-away rendition of the coliseum-sized facility. The NIF requires integration of about 40,000 atypical control points, must be highly automated and robust, and will operate continuously around the clock. The control system coordinates several experimental cycles concurrently, each at different stages of completion. Furthermore, facilities such as the NIF represent major capital investments that will be operated, maintained, and upgraded for decades. The computers, control subsystems, and functionality must be relatively easy to extend or replace periodically with newer technology.

  18. Facility Requirements for Integrated Learning Systems.

    ERIC Educational Resources Information Center

    Knirk, Frederick G.

    1992-01-01

    Discusses features in the physical environment that need to be considered for integrated learning systems (ILSs). Highlights include ergonomics; lighting, including contrast and colors; space, furniture, and equipment, including keyboard, monitor, software, and printer; ambient noise and acoustics; temperature, humidity, and air quality control;…

  19. Monolithically integrated absolute frequency comb laser system

    DOEpatents

    Wanke, Michael C.

    2016-07-12

    Rather than down-convert optical frequencies, a QCL laser system directly generates a THz frequency comb in a compact monolithically integrated chip that can be locked to an absolute frequency without the need of a frequency-comb synthesizer. The monolithic, absolute frequency comb can provide a THz frequency reference and tool for high-resolution broad band spectroscopy.

  20. Knowledge-based approach to system integration

    NASA Technical Reports Server (NTRS)

    Blokland, W.; Krishnamurthy, C.; Biegl, C.; Sztipanovits, J.

    1988-01-01

    To solve complex problems one can often use the decomposition principle. However, a problem is seldom decomposable into completely independent subproblems. System integration deals with problem of resolving the interdependencies and the integration of the subsolutions. A natural method of decomposition is the hierarchical one. High-level specifications are broken down into lower level specifications until they can be transformed into solutions relatively easily. By automating the hierarchical decomposition and solution generation an integrated system is obtained in which the declaration of high level specifications is enough to solve the problem. We offer a knowledge-based approach to integrate the development and building of control systems. The process modeling is supported by using graphic editors. The user selects and connects icons that represent subprocesses and might refer to prewritten programs. The graphical editor assists the user in selecting parameters for each subprocess and allows the testing of a specific configuration. Next, from the definitions created by the graphical editor, the actual control program is built. Fault-diagnosis routines are generated automatically as well. Since the user is not required to write program code and knowledge about the process is present in the development system, the user is not required to have expertise in many fields.

  1. Energy Integrated Lighting-Heating-Cooling System.

    ERIC Educational Resources Information Center

    Meckler, Gershon; And Others

    1964-01-01

    Energy balance problems in the design of office buildings are analyzed. Through the use of integrated systems utilizing dual purpose products, a controlled environment with minimum expenditure of energy, equipment and space can be provided. Contents include--(1) office building occupancy loads, (2) office building heating load analysis, (3) office…

  2. The Habitat Demonstration Unit System Integration

    NASA Technical Reports Server (NTRS)

    Kennedy, Kriss J.; Gill, Tracy; Tri, Terry; Howe, Scott

    2009-01-01

    The Lunar Surface System Habitat Demonstration Unit (HDU) will require the project team to integrate a variety of contributions from NASA centers and potential outside collaborators and poses a challenge in integrating these disparate efforts into a cohesive architecture. To accomplish the development of the HDU from conception in June 2009 to rollout for operations in July 2010, the HDU team is using several strategies to mitigate risks and bring the separate efforts together. First, a set of design standards is being developed to define the interfaces between the various systems of HDU and to the payloads, such as the Geology Lab, that those systems will support. Scheduled activities such as early fit-checks and the utilization of a Habitat avionics test bed prior to equipment installation into HDU. A coordinated effort to establish simplified Computer Aided Design standards and the utilization of a modeling and simulation systems will aid in design and integration concept development. Finally, decision processes on the shell development including the assembly sequence and the transportation have been fleshed out early on HDU to maximize the efficiency of both integration and field operations.

  3. Software design of missile integrated test system

    NASA Astrophysics Data System (ADS)

    Dai, Jing; Zhang, Ping; Li, Xingshan; Liao, Canxing; Wang, Zongli

    2006-11-01

    Based on virtual instrument, software design precept of missile integrated test system is proposed in this paper. The integrated test system software was developed under modular, intelligent and structured precept. In this way, the expansion capability of the test software is improved, and it is very convenient for second-development and maintenance. This test software is of higher-degree automation, its integrated test environment gives full play to the hardware platform of the missile integrated test system. In response to the specific hardware configuration of the test system and special missile test requirements, the application of test resources was optimized in the test procedure to improve test speed greatly and satisfy the power-on time limit for missile test. At the same time, by applying multithreading and hardware clock on a data acquisition card, accurate data acquisition, data calculating and data injecting can be completed in a millisecond to satisfy the harsh missile test requirement. This automatic test equipment can automatically test the nose cabin and control cabin only of a missile and a training missile; all the missile test items can be accomplished in a short period of time to enhance the efficiency and reliability of the test.

  4. Integrated Propulsion Data System Public Web Site

    NASA Technical Reports Server (NTRS)

    Hamilton, Kimberly

    2001-01-01

    The Integrated Propulsion Data System's (IPDS) focus is to provide technologically-advanced philosophies of doing business at SSC that will enhance the existing operations, engineering and management strategies and provide insight and metrics to assess their daily impacts, especially as related to the Propulsion Test Directorate testing scenarios for the 21st Century.

  5. The system integration of image processing

    NASA Astrophysics Data System (ADS)

    Chen, Qi-xing; Wu, Qin-zhang; Gao, Xiao-dong; Ren, Guo-qiang

    2008-03-01

    An integration system was designed to apply to the remote communication of optics and electronics detection systems, which was integrated with programmable DSP and FPGA chirps in addition to a few Application Specific Integrated Circuits (ASICs). It could achieve image binarization, image enhancement, data encryption, image compression encoding, channel encoding, data interleaving, etc., and the algorithms of these functions might be renewed or updated easily. The CCD color camera being a signal source, experiments had been done on the platform with a DSP chirp and a FPGA one. The FPGA chirp mainly realized the reconstruction of image's brightness signal and the production of various timing signals, and the DSP chirp mainly accomplished the other functions. The algorithms to compress image data were based on discrete cosine transformation (DCT) and discrete wavelet transformation (DWT), respectively. The experiment results showed that the developed platform was characterized by flexibility, programmability and reconfigurability. The integration system is well suitable for the remote communication of optics and electronics detection systems.

  6. Extracting Data From Integrated Student Information Systems.

    ERIC Educational Resources Information Center

    Yost, Michael

    An integrated student information system (ISIS) at Trinity University (Texas) is described with attention to how data are entered and how data are extracted for purposes of institutional research. The structure of the original ISIS files, the extract files, and the Statistical Package for the Social Sciences (SPSS) files is examined. An outline is…

  7. The Bright Future of Integrated Learning Systems.

    ERIC Educational Resources Information Center

    Bracey, Gerald W.

    1992-01-01

    Considers the future of integrated learning systems (ILSs) and examines hypermedia as the most promising new interactive technology for education. Topics discussed include changes in technology; the use of computers in schools; the value of video games; the impact of ILSs on schools; and cognitive science and cognitive psychology. (LRW)

  8. Integrated communications and optical navigation system

    NASA Astrophysics Data System (ADS)

    Mueller, J.; Pajer, G.; Paluszek, M.

    2013-12-01

    The Integrated Communications and Optical Navigation System (ICONS) is a flexible navigation system for spacecraft that does not require global positioning system (GPS) measurements. The navigation solution is computed using an Unscented Kalman Filter (UKF) that can accept any combination of range, range-rate, planet chord width, landmark, and angle measurements using any celestial object. Both absolute and relative orbit determination is supported. The UKF employs a full nonlinear dynamical model of the orbit including gravity models and disturbance models. The ICONS package also includes attitude determination algorithms using the UKF algorithm with the Inertial Measurement Unit (IMU). The IMU is used as the dynamical base for the attitude determination algorithms. This makes the sensor a more capable plug-in replacement for a star tracker, thus reducing the integration and test cost of adding this sensor to a spacecraft. Recent additions include an integrated optical communications system which adds communications, and integrated range and range rate measurement and timing. The paper includes test results from trajectories based on the NASA New Horizons spacecraft.

  9. The Self-System in Integral Counseling

    ERIC Educational Resources Information Center

    Ingersoll, R. Elliott; Cook-Greuter, Susanne R.

    2007-01-01

    The authors introduce the integral model of the self-system and, using that model, describe the dynamics of healthy growth and the development of psychogenic pathology. Self-identification is described as "sliding" in nature, and stage theories for self-related lines are outlined to help clinicians understand the characteristics of each stage the…

  10. Multiloop Integral System Test (MIST): Final report

    SciTech Connect

    Geissler, G.O. . Nuclear Power Div. Babcock and Wilcox Co., Alliance, OH . Research and Development Div.)

    1990-08-01

    The Multiloop Integral System Test (MIST) is part of a multiphase program started in 1983 to address small-break loss-of-coolant accidents (SBLOCAs) specific to Babcock Wilcox designed plants. MIST is sponsored by the US Nuclear Regulatory Commission, the Babcock Wilcox Owners Group, the Electric Power Research Institute, and Babcock and Wilcox. The unique features of the Babcock Wilcox design, specifically the hot leg U-bends and steam generators, prevented the use of existing integral system data or existing integral facilities to address the thermal-hydraulic SBLOCA questions. MIST and two other supporting facilities were specifically designed and constructed for this program, and an existing facility--the Once-Through Integral System (OTIS)--was also used. Data from MIST and the other facilities will be used to benchmark the adequacy of system codes, such as RELAP5 and TRAC, for predication abnormal plant transients. The MIST Program is reported in 11 volumes. The program is summarized in Volume 1; Volumes 2 through 8 describes groups of tests by test type, Volume 9 presents inter-group comparisons, Volume 10 provides comparisons between the calculations of RELAP5/MOD2 and MIST observations, and Volume 11 presents the later Phase 4 tests. This Volume 11 pertains to MIST Phase IV tests performed to investigate risk dominant transients and non-LOCA events. 12 refs., 229 figs., 36 tabs.

  11. Multiloop Integral System Test (MIST): Final report

    SciTech Connect

    Geissler, G.O.

    1990-08-01

    The Multiloop Integral System Test (MIST) is part of a multiphase program started in 1983 to address small-break loss-of-coolant accidents (SBLOCAs) specific to Babcock Wilcox designed plants. MIST is sponsored by the US Nuclear Regulatory Commission, the Babcock Wilcox Owners Group, the Electric Power Research Institute, and Babcock Wilcox. The unique features of the Babcock Wilcox design, specifically the hot leg U-bends and steam generators, prevented the use of existing integral system data or existing integral facilities to address the thermal-hydraulic SBLOCA questions. MIST and two supporting facilities were specifically designed and constructed for this program, and an existing facility -- the Once-Through Integral System (OTIS) -- was also used. Data from MIST and the other facilities will be used to benchmark the adequacy of system codes, such as RELAP5 and TRAC, for predicting abnormal plant transients. The MIST Program is reported in 11 volumes. The program is summarized in Volume 1; Volumes 2 through 8 describes groups of tests by test type, Volume 9 presents inter-group comparisons; Volume 10 provides comparisons between the calculations of RELAP5/MOD 2 and MIST observations, and Volume 11 presents the later Phase 4 tests. This Volume 11 addendum pertains to MIST natural circulation tests. 2 refs., 161 figs., 8 tabs.

  12. 78 FR 39280 - Integrated System Power Rates

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-01

    .... 888, 61 FR 21,540 (5/10/1996), FERC Stats. & Regs. ] 31,036 (1996), order on reh'g, Order No. 888-A, 62 FR 12,274 (3/14/ 1997), FERC Stats. & Regs. ] 31,048 (1997), order on reh'g, Order No. 888-B, 81... Southwestern Power Administration Integrated System Power Rates AGENCY: Southwestern Power Administration,...

  13. 75 FR 1363 - Integrated System Power Rates

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-11

    ... schedule. On September 23, 2009, Southwestern published notice in the Federal Register, (74 FR 48527), of a... Register, September 23, 2009, (74 FR 48527). The consultation and comment period was shortened from the 90... Southwestern Power Administration Integrated System Power Rates AGENCY: Southwestern Power Administration,...

  14. 78 FR 62616 - Integrated System Power Rates

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-22

    ..., Southwestern published notice in the Federal Register (78 FR 39280) of a 60-day comment period, together with a..., 2013, (78 FR 39280). The consultation and comment period was shortened from the 90 days provided for in... Southwestern Power Administration Integrated System Power Rates AGENCY: Southwestern Power Administration,...

  15. 77 FR 2521 - Integrated System Power Rates

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-18

    ..., Southwestern published notice in the Federal Register, (76 FR 48159), of a 60-day comment period, together with... were announced by notice published in the Federal Register, August 8, 2011, (76 FR 48159). The... Southwestern Power Administration Integrated System Power Rates AGENCY: Southwestern Power Administration,...

  16. 76 FR 48159 - Integrated System Power Rates

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-08

    ... by Public Utilities and Transmitting Utilities, Order No. 888, 61 FR 21,540 (5/10/1996), FERC Stats. & Regs. ] 31,036 (1996), order on reh'g, Order No. 888-A, 62 FR 12,274 (3/14/ 1997), FERC Stats. & Regs... Southwestern Power Administration Integrated System Power Rates AGENCY: Southwestern Power Administration,...

  17. Agent Architecture for Aviation Data Integration System

    NASA Technical Reports Server (NTRS)

    Kulkarni, Deepak; Wang, Yao; Windrem, May; Patel, Hemil; Wei, Mei

    2004-01-01

    This paper describes the proposed agent-based architecture of the Aviation Data Integration System (ADIS). ADIS is a software system that provides integrated heterogeneous data to support aviation problem-solving activities. Examples of aviation problem-solving activities include engineering troubleshooting, incident and accident investigation, routine flight operations monitoring, safety assessment, maintenance procedure debugging, and training assessment. A wide variety of information is typically referenced when engaging in these activities. Some of this information includes flight recorder data, Automatic Terminal Information Service (ATIS) reports, Jeppesen charts, weather data, air traffic control information, safety reports, and runway visual range data. Such wide-ranging information cannot be found in any single unified information source. Therefore, this information must be actively collected, assembled, and presented in a manner that supports the users problem-solving activities. This information integration task is non-trivial and presents a variety of technical challenges. ADIS has been developed to do this task and it permits integration of weather, RVR, radar data, and Jeppesen charts with flight data. ADIS has been implemented and used by several airlines FOQA teams. The initial feedback from airlines is that such a system is very useful in FOQA analysis. Based on the feedback from the initial deployment, we are developing a new version of the system that would make further progress in achieving following goals of our project.

  18. Integrated computer control system architectural overview

    SciTech Connect

    Van Arsdall, P.

    1997-06-18

    This overview introduces the NIF Integrated Control System (ICCS) architecture. The design is abstract to allow the construction of many similar applications from a common framework. This summary lays the essential foundation for understanding the model-based engineering approach used to execute the design.

  19. UAS-NAS Integrated Human in the Loop: Test Environment Report

    NASA Technical Reports Server (NTRS)

    Murphy, Jim; Otto, Neil; Jovic, Srba

    2015-01-01

    The desire and ability to fly Unmanned Aircraft Systems (UAS) in the National Airspace System (NAS) is of increasing urgency. The application of unmanned aircraft to perform national security, defense, scientific, and emergency management are driving the critical need for less restrictive access by UAS to the NAS. UAS represent a new capability that will provide a variety of services in the government (public) and commercial (civil) aviation sectors. The growth of this potential industry has not yet been realized due to the lack of a common understanding of what is required to safely operate UAS in the NAS. NASA's UAS Integration in the NAS Project is conducting research in the areas of Separation Assurance/Sense and Avoid Interoperability (SSI), Human Systems Integration (HSI), and Communication to support reducing the barriers of UAS access to the NAS. This research was broken into two research themes namely, UAS Integration and Test Infrastructure. UAS Integration focuses on airspace integration procedures and performance standards to enable UAS integration in the air transportation system, covering Sense and Avoid (SAA) performance standards, command and control performance standards, and human systems integration. The focus of the Test Infrastructure theme was to enable development and validation of airspace integration procedures and performance standards, including the execution of integrated test and evaluation. In support of the integrated test and evaluation efforts, the Project developed an adaptable, scalable, and schedulable relevant test environment incorporating live, virtual, and constructive elements capable of validating concepts and technologies for unmanned aircraft systems to safely operate in the NAS. To accomplish this task, the Project planned to conduct three integrated events: a Human-in-the-Loop simulation and two Flight Test series that integrated key concepts, technologies and/or procedures in a relevant air traffic environment. Each of

  20. Integrated voice and visual systems research topics

    NASA Technical Reports Server (NTRS)

    Williams, Douglas H.; Simpson, Carol A.

    1986-01-01

    A series of studies was performed to investigate factors of helicopter speech and visual system design and measure the effects of these factors on human performance, both for pilots and non-pilots. The findings and conclusions of these studies were applied by the U.S. Army to the design of the Army's next generation threat warning system for helicopters and to the linguistic functional requirements for a joint Army/NASA flightworthy, experimental speech generation and recognition system.

  1. Integrative Genomics and Computational Systems Medicine

    SciTech Connect

    McDermott, Jason E.; Huang, Yufei; Zhang, Bing; Xu, Hua; Zhao, Zhongming

    2014-01-01

    The exponential growth in generation of large amounts of genomic data from biological samples has driven the emerging field of systems medicine. This field is promising because it improves our understanding of disease processes at the systems level. However, the field is still in its young stage. There exists a great need for novel computational methods and approaches to effectively utilize and integrate various omics data.

  2. Integration of pyrotechnics into aerospace systems

    NASA Technical Reports Server (NTRS)

    Bement, Laurence J.; Schimmel, Morry L.

    1993-01-01

    The application of pyrotechnics to aerospace systems has been resisted because normal engineering methods cannot be used in design and evaluation. Commonly used approaches for energy sources, such as electrical, hydraulic and pneumatic, do not apply to explosive and pyrotechnic devices. This paper introduces the unique characteristics of pyrotechnic devices, describes how functional evaluations can be conducted, and demonstrates an engineering approach for pyrotechnic integration. Logic is presented that allows evaluation of two basic types of pyrotechnic systems to demonstrate functional margin.

  3. Utility integration issues of residential photovoltaic systems

    NASA Astrophysics Data System (ADS)

    Yamayee, Z. A.; Peschon, J.

    1981-05-01

    The economic aspects of residential solar photovoltaic (SPV) systems are discussed from the electric utility perspective. The following schemes of SPV integration are considered: (1) SPV with complete utility buy-back and backup; (2) SPV with utility system storage; and (3) SPV with residential storage. Estimates are made of the price that the utility might pay for SPV owner's surplus energy compared to what it would charge for deficits by evaluating economic savings of SVP to the utility.

  4. Integrated Management System - Scope, Possibilities And Methodology

    NASA Astrophysics Data System (ADS)

    Čekanová, Katarína

    2015-06-01

    Organizations are becoming more aware of the importance of integrated management systems (IMS). Interest in this subject indicates that IMS are seen as "management systems of the future". Based on this, the aim of this articles characterizes the possibility of building IMS through the identification of common elements and specific requirements in accordance with the ISO 9001, ISO 14001 and OHSAS 18001 professional references. Part of the article is the methodology of building IMS in the organization.

  5. Integrating commercial and legacy systems with EPICS

    SciTech Connect

    Hill, J.O.; Kasemir, K.U.; Kowalkowski, J.B.

    1997-09-01

    The Experimental Physics and Industrial Control System (EPICS) is a software toolkit, developed by a worldwide collaboration, which significantly reduces the level of effort required to implement a new control system. Recent developments now also significantly reduce the level of effort required to integrate commercial, legacy and/or site-authored control systems with EPICS. This paper will illustrate with an example both the level and type of effort required to use EPICS with other control system components as well as the benefits that may arise.

  6. Video Guidance Sensor System With Integrated Rangefinding

    NASA Technical Reports Server (NTRS)

    Book, Michael L. (Inventor); Bryan, Thomas C. (Inventor); Howard, Richard T. (Inventor); Roe, Fred Davis, Jr. (Inventor); Bell, Joseph L. (Inventor)

    2006-01-01

    A video guidance sensor system for use, p.g., in automated docking of a chase vehicle with a target vehicle. The system includes an integrated rangefinder sub-system that uses time of flight measurements to measure range. The rangefinder sub-system includes a pair of matched photodetectors for respectively detecting an output laser beam and return laser beam, a buffer memory for storing the photodetector outputs, and a digitizer connected to the buffer memory and including dual amplifiers and analog-to-digital converters. A digital signal processor processes the digitized output to produce a range measurement.

  7. Integration of historical aerial photography and a geographic information system to evaluate the impact of human activities in a cypress-tupelo swamp

    SciTech Connect

    Jensen, J.R.; Burkhalter, S.; Althausen, J.D.; Narumalani, S.; Mackey, H.E. Jr.

    1993-12-31

    The Savannah River Site (SRS) is a 78,000 ha Department of Energy (DOE) facility that borders the Savannah River in the south-west portion of South Carolina. It includes a 3,800 ha cypress-tupelo swamp where commercial lumbering activities took place prior to the purchase of the land by the federal government in 1951. Since then, the DOE commenced nuclear production operations which resulted in the release of thermal effluent into the streams entering the Savannah River swamp system. The thermal effluent also had an impact on the swamp through the creation of sedimentation deltas. The purpose of this research is to identify areas of anthropogenic impact on the swamp and to delineate any areas that may still be considered pristine. Large-scale historical aerial photography of the swamp for 1938, 1943, 1951, and 1973 were photo-interpreted and used to develop a geographic information system (GIS) database. Logging features such as haul lines, drag points, harvest areas and roads were identified from black-and-white aerial photographs (1938-1973) and converted into a digital format. Sediment deltas were interpreted from 1976, 1981 and 1988 color aerial photography. Geometric transformations and GIS data analysis operations were performed to delineate areas impacted by man`s activities over the 48-year time period. Only 1391 ha of swamp can still can be considered pristine. Approximately 63% of the swamp has been altered from its original state, either by logging practices or the effects of sediment loading from thermal effluent. This method of mapping the pristine areas of the swamp allows SRS environmental scientists the opportunity to have a priori knowledge about undisturbed swamp forest environments, which they may use as a baseline for restoration or wetland mitigation projects.

  8. [A research on healthcare integrating model of medical information system].

    PubMed

    Lü, Xudong; Duan, Huilong

    2005-02-01

    System integration is inevitable since there are lots of heterogeneous medical information systems in the complicated medical environment. The current medical communication standards often focus on one aspect of the integration and do not provide a general scheme. Based on the analysis of the application of medical integration, the medical integration model HIM (Healthcare integrating model) is put forward, and the dataflow integration framework, function integration framework and interface integration framework in the HIM are designed subsequently. HIM provides a 3-D scheme for the integration of medical information systems, which not only contains the three aspects of integration application vertically, but covers the whole medical area horizontally. PMID:15762128

  9. An integrated practical implementation of continuous aqueous two-phase systems for the recovery of human IgG: From the microdevice to a multistage bench-scale mixer-settler device.

    PubMed

    Espitia-Saloma, Edith; Vâzquez-Villegas, Patricia; Rito-Palomares, Marco; Aguilar, Oscar

    2016-05-01

    Aqueous two-phase systems (ATPS) are a liquid-liquid extraction technology with clear process benefits; however, its lack of industrial embracement is still a challenge to overcome. Antibodies are a potential product to be recovered by ATPS in a commercial context. The objective of this work is to present a more integral approach of the different isolated strategies that have arisen in order to enable a practical, generic implementation of ATPS, using human immunoglobulin G (IgG) as experimental model. A microfluidic device is used for ATPS parameters preselection for product recovery. ATPS were continuously operated in a mixer-settler device in one stage, multistage and multistage with recirculation configuration. Single-stage pure IgG extraction with a polyethylene glycol (PEG) 3350-phophates ATPS within continuous operation allowed a 65% recovery. Further implementation of a multistage platform promoted a higher particle partitioning reaching a 90% recovery. The processing of IgG from a cell supernatant culture harvest in a multistage system with top phase recirculation resulted in 78% IgG recovery in bottom phase. This work conjugates three not widely spread methodologies for ATPS: microfluidics, continuous and multistage operation. PMID:26848821

  10. Orion ECLSS/Suit System - Ambient Pressure Integrated Suit Test

    NASA Technical Reports Server (NTRS)

    Barido, Richard A.

    2012-01-01

    The Ambient Pressure Integrated Suit Test (APIST) phase of the integrated system testing of the Orion Vehicle Atmosphere Revitalization System (ARS) technology was conducted for the Multipurpose Crew Vehicle (MPCV) Program within the National Aeronautics and Space Administration (NASA) Exploration Systems Mission Directorate. Crew and Thermal Systems Division performed this test in the eleven-foot human-rated vacuum chamber at the NASA Johnson Space Center. This testing is the first phase of suit loop testing to demonstrate the viability of the Environmental Control and Life Support System (ECLSS) being developed for Orion. APIST is the first in a series, which will consist of testing development hardware including the Carbon dioxide and Moisture Removal Amine Swing-bed (CAMRAS) and the air revitalization loop fan with human test subjects in pressure suits at varying suit pressures. Follow-on testing, to be conducted in 2013, will utilize the CAMRAS and a development regulator with human test subjects in pressure suits at varying cabin and suit pressures. This paper will discuss the results and findings of APIST and will also discuss future testing.

  11. Energy Systems Integration Facility (ESIF): Golden, CO - Energy Integration

    SciTech Connect

    Sheppy, Michael; VanGeet, Otto; Pless, Shanti; Gaul, Chris

    2015-03-01

    At NREL's Energy Systems Integration Facility (ESIF) in Golden, Colo., scientists and engineers work to overcome challenges related to how the nation generates, delivers and uses energy by modernizing the interplay between energy sources, infrastructure, and data. Test facilities include a megawatt-scale ac electric grid, photovoltaic simulators and a load bank. Additionally, a high performance computing data center (HPCDC) is dedicated to advancing renewable energy and energy efficient technologies. A key design strategy is to use waste heat from the HPCDC to heat parts of the building. The ESIF boasts an annual EUI of 168.3 kBtu/ft2. This article describes the building's procurement, design and first year of performance.

  12. Clinical and laboratory features of human herpesvirus 6 chromosomal integration.

    PubMed

    Clark, D A

    2016-04-01

    Human herpesvirus 6 (HHV-6) comprises two separate viruses, HHV-6A and HHV-6B, although this distinction is not commonly made. HHV-6B is ubiquitous in the population with primary infection usually occurring in early childhood, and often resulting in febrile illness. HHV-6B is also recognized as a pathogen in the immunocompromised host, particularly in transplant recipients. HHV-6A is less well characterized and may have a more restricted prevalence. Both viruses are unique among the human herpesviruses in that the entire viral genome can be found integrated into the telomeric regions of host cell chromosomes. Approximately 1% of persons have inherited integrated viral sequences through the germline, and these individuals characteristically have very high viral loads in blood and other sample types. Emerging evidence suggests that HHV-6A and HHV-6B chromosomal integration may not just be an uncommon biological observation, but more likely a characteristic of the replication properties of these viruses. The integrated viral genome appears capable of excision from the chromosomal site and potentially allows viral replication. The clinical consequences of inherited chromosomally integrated HHV-6 have yet to be fully appreciated. PMID:26802216

  13. Activities of Human Immunodeficiency Virus (HIV) Integration Protein In vitro: Specific Cleavage and Integration of HIV DNA

    NASA Astrophysics Data System (ADS)

    Bushman, Frederic D.; Craigie, Robert

    1991-02-01

    Growth of human immunodeficiency virus (HIV) after infection requires the integration of a DNA copy of the viral RNA genome into a chromosome of the host. Here we present a simple in vitro system that carries out the integration reaction and the use of this system to probe the mechanism of integration. The only HIV protein necessary is the integration (IN) protein, which has been overexpressed in insect cells and then partially purified. DNA substrates are supplied as oligonucleotides that match the termini of the linear DNA product of reverse transcription. In the presence of HIV IN protein, oligonucleotide substrates are cleaved to generate the recessed 3' ends that are the precursor for integration, and the cleaved molecules are efficiently inserted into a DNA target. Analysis of reaction products reveals that HIV IN protein joins 3' ends of the viral DNA to 5' ends of cuts made by IN protein in the DNA target. We have also used this assay to characterize the sequences at the ends of the viral DNA involved in integration. The assay provides a simple screen for testing candidate inhibitors of HIV IN protein; some such inhibitors might have useful antiviral activity.

  14. Integrated monitoring and surveillance system for SNM.

    SciTech Connect

    Aumeier, S.; Brush, B.; Ewing, T.; Gross, K.; Kotter, D.; Laurin-Kovitz, K.; Walters, G.; Wegerich, S.

    1999-08-04

    Complex special nuclear material (SNM) storage systems can benefit from automated monitoring and data integration systems that maximize safety and security and optimize system maintainability. Current methods of verification, which rely on physical access, are costly and labor intensive. A prototype data analysis. system for nuclear material monitoring is being developed through a joint effort by Argonne National Laboratory (ANL) and Lockheed Martin Idaho Technologies Company (LMITCO). The system synthesizes information from various sources and applies advanced data analysis to predict sensor faults and detect material instabilities and security/safeguards problems. The system makes use of Argonne's Multivariate State Estimation Technique, or MSET, to provide an early warning system for the performance of sensors and processes, The system is being implemented and tested at the Safeguard Technology Evaluation Laboratory (STEL) at ANL-W. The STEL was installed at a Fuel Manufacturing Facility (FMF) special nuclear materials vault at ANL-W in 1997 as part of a DOE Plutonium Focus Area Project. The STEL provides the infrastructure for the demonstration and integration of technologies for monitoring plutonium-bearing materials in various storage configurations. Real sensors located within the STEL are being used to ''calibrate'' and validate. software while simulated sensors are used to mockup larger-scale problems. Preliminary system design and testing results are discussed.

  15. Human nervous system function emulator.

    PubMed

    Frenger, P

    2000-01-01

    This paper describes a modular, extensible, open-systems design for a multiprocessor network which emulates the major functions of the human nervous system. Interchangeable hardware/software components, a socketed software bus with plug-and-play capability and self diagnostics are included. The computer hardware is based on IEEE P996.1 bus cards. Its operating system utilizes IEEE 1275 standard software. Object oriented design techniques and programming are featured. A machine-independent high level script-based command language was created for this project. Neural anatomical structures which were emulated include the cortex, brainstem, cerebellum, spinal cord, autonomic and peripheral nervous systems. Motor, sensory, autoregulatory, and higher cognitive artificial intelligence, behavioral and emotional functions are provided. The author discusses how he has interfaced this emulator to machine vision, speech recognition/speech synthesis, an artificial neural network and a dexterous hand to form an android robotic platform. PMID:10834247

  16. Integrated online job-shop scheduling system

    NASA Astrophysics Data System (ADS)

    Zhao, Xing; Chen, Kuan H.; Luh, Peter B.; Chiueh, T. D.; Chang, ShihChang; Thakur, Lakshman S.

    1999-11-01

    The rapid development of information technology and e- commerce requires fast response form scheduling systems. Based on the Lagrangian relaxation approach for job shop scheduling, this paper present an integrated system that will generate schedules quickly. The Lagrangian relaxation approach is an iterative optimization process, where dynamic programming is solved in each iteration. Since dynamic programming is computational expensive especially for large problems, this paper develops the simplified dynamic programming, which will cut the computation time of each iteration by one order. Furthermore, a digital circuit to be embedded in PC is designed to implement the iterative optimization algorithm, leading to another order of speed improvement. The resulting integrated scheduling system consists of the hardware for optimization and the related software. It is estimated that two orders of magnitude gain in speed can be obtained, which will make on-line scheduling for practical job shops possible.

  17. Integrated computer-aided retinal photocoagulation system

    NASA Astrophysics Data System (ADS)

    Barrett, Steven F.; Wright, Cameron H. G.; Oberg, Erik D.; Rockwell, Benjamin A.; Cain, Clarence P.; Jerath, Maya R.; Rylander, Henry G., III; Welch, Ashley J.

    1996-05-01

    Successful retinal tracking subsystem testing results in vivo on rhesus monkeys using an argon continuous wave laser and an ultra-short pulse laser are presented. Progress on developing an integrated robotic retinal laser surgery system is also presented. Several interesting areas of study have developed: (1) 'doughnut' shaped lesions that occur under certain combinations of laser power, spot size, and irradiation time complicating measurements of central lesion reflectance, (2) the optimal retinal field of view to achieve simultaneous tracking and lesion parameter control, and (3) a fully digital versus a hybrid analog/digital tracker using confocal reflectometry integrated system implementation. These areas are investigated in detail in this paper. The hybrid system warrants a separate presentation and appears in another paper at this conference.

  18. Ultra Small Integrated Optical Fiber Sensing System

    PubMed Central

    Van Hoe, Bram; Lee, Graham; Bosman, Erwin; Missinne, Jeroen; Kalathimekkad, Sandeep; Maskery, Oliver; Webb, David J.; Sugden, Kate; Van Daele, Peter; Van Steenberge, Geert

    2012-01-01

    This paper introduces a revolutionary way to interrogate optical fiber sensors based on fiber Bragg gratings (FBGs) and to integrate the necessary driving optoelectronic components with the sensor elements. Low-cost optoelectronic chips are used to interrogate the optical fibers, creating a portable dynamic sensing system as an alternative for the traditionally bulky and expensive fiber sensor interrogation units. The possibility to embed these laser and detector chips is demonstrated resulting in an ultra thin flexible optoelectronic package of only 40 μm, provided with an integrated planar fiber pigtail. The result is a fully embedded flexible sensing system with a thickness of only 1 mm, based on a single Vertical-Cavity Surface-Emitting Laser (VCSEL), fiber sensor and photodetector chip. Temperature, strain and electrodynamic shaking tests have been performed on our system, not limited to static read-out measurements but dynamically reconstructing full spectral information datasets.

  19. Integrated safety management system verification: Volume 2

    SciTech Connect

    Christensen, R.F.

    1998-08-10

    Department of Energy (DOE) Policy (P) 450.4, Safety Management System Policy, commits to institutionalization of an Integrated Safety Management System (ISMS) throughout the DOE complex. The DOE Acquisition Regulations (DEAR, 48 CFR 970) requires contractors to manage and perform work in accordance with a documented Integrated Safety Management System (ISMS). Guidance and expectations have been provided to PNNL by incorporation into the operating contract (Contract DE-ACM-76FL0 1830) and by letter. The contract requires that the contractor submit a description of their ISMS for approval by DOE. PNNL submitted their proposed Safety Management System Description for approval on November 25,1997. RL tentatively approved acceptance of the description pursuant to a favorable recommendation from this review. The Integrated Safety Management System Verification is a review of the adequacy of the ISMS description in fulfilling the requirements of the DEAR and the DOE Policy. The purpose of this review is to provide the Richland Operations Office Manager with a recommendation for approval of the ISMS description of the Pacific Northwest Laboratory based upon compliance with the requirements of 49 CFR 970.5204(-2 and -78); and to verify the extent and maturity of ISMS implementation within the Laboratory. Further the review will provide a model for other DOE laboratories managed by the Office of Assistant Secretary for Energy Research.

  20. Turnkey CAD/CAM systems' integration with IPAD systems

    NASA Technical Reports Server (NTRS)

    Blauth, R. E.

    1980-01-01

    Today's commercially available turnkey CAD/CAM systems provide a highly interactive environment, and support many specialized application functions for the design/drafting/manufacturing process. This paper presents an overview of several aerospace companies which have successfully integrated turnkey CAD/CAM systems with their own company wide engineering and manufacturing systems. It also includes a vendor's view of the benefits as well as the disadvantages of such integration efforts. Specific emphasis is placed upon the selection of standards for representing geometric engineering data and for communicating such information between different CAD/CAM systems.

  1. Performance of Integrated Hydronic Heating Systems.

    SciTech Connect

    BUTCHER,T.A.

    2007-12-20

    A variety of system configurations are used in North America to meet the heating and domestic hot water needs of single-family homes. This includes, for example: warm air furnaces with electric water heaters; boilers with integrated hot water coils; and boilers with 'indirect' hot water storage tanks. Integrated hydronic systems which provide both heat and hot water are more popular only in the Northeast and mid-Atlantic regions. For those making decisions about configurations of these integrated hydronic systems, including control options, little information is available concerning the annual energy cost implications of these decisions. This report presents results of a project to use a direct load emulation approach to measure the performance of hydronic systems, develop performance curves, and to provide decision tools to consumers. This is a laboratory measurement system involving direct energy input and output measurements under different load patterns. These results are then used to develop performance correlations for specific systems that can be used to predict energy use in specific applications. A wide range of system types have been tested under this project including conventional boilers with 'tankless' internal coils for domestic hot water production, boilers with indirect external storage tanks, tank type water heaters which may also be used for space heating, condensing oil- and gas-fired systems, and systems with custom control features. It is shown that low load and idle energy losses can have a very large impact on the total annual energy use and that the potential energy savings associated with replacing old equipment with newer, high efficiency equipment with low losses at idle or low load can be in the 25% range. These savings are larger than simple combustion efficiency measurements would indicate.

  2. Current advances in systems and integrative biology

    PubMed Central

    Robinson, Scott W.; Fernandes, Marco; Husi, Holger

    2014-01-01

    Systems biology has gained a tremendous amount of interest in the last few years. This is partly due to the realization that traditional approaches focusing only on a few molecules at a time cannot describe the impact of aberrant or modulated molecular environments across a whole system. Furthermore, a hypothesis-driven study aims to prove or disprove its postulations, whereas a hypothesis-free systems approach can yield an unbiased and novel testable hypothesis as an end-result. This latter approach foregoes assumptions which predict how a biological system should react to an altered microenvironment within a cellular context, across a tissue or impacting on distant organs. Additionally, re-use of existing data by systematic data mining and re-stratification, one of the cornerstones of integrative systems biology, is also gaining attention. While tremendous efforts using a systems methodology have already yielded excellent results, it is apparent that a lack of suitable analytic tools and purpose-built databases poses a major bottleneck in applying a systematic workflow. This review addresses the current approaches used in systems analysis and obstacles often encountered in large-scale data analysis and integration which tend to go unnoticed, but have a direct impact on the final outcome of a systems approach. Its wide applicability, ranging from basic research, disease descriptors, pharmacological studies, to personalized medicine, makes this emerging approach well suited to address biological and medical questions where conventional methods are not ideal. PMID:25379142

  3. Integrated communication and control systems. I - Analysis

    NASA Technical Reports Server (NTRS)

    Halevi, Yoram; Ray, Asok

    1988-01-01

    The paper presents the results of an ICCS analysis focusing on discrete-time control systems subject to time-varying delays. The present analytical technique is applicable to integrated dynamic systems such as those encountered in advanced aircraft, spacecraft, and the real-time control of robots and machine tools via a high-speed network within an autonomous manufacturing environment. The significance of data latency and missynchronization between individual system components in ICCS networks is discussed in view of the time-varying delays.

  4. Clinical information systems for integrated healthcare networks.

    PubMed Central

    Teich, J. M.

    1998-01-01

    In the 1990's, a large number of hospitals and medical practices have merged to form integrated healthcare networks (IHN's). The nature of an IHN creates new demands for information management, and also imposes new constraints on information systems for the network. Important tradeoffs must be made between homogeneity and flexibility, central and distributed governance, and access and confidentiality. This paper describes key components of clinical information systems for IHN's, and examines important design decisions that affect the value of such systems. Images Figure 1 PMID:9929178

  5. A geometrical formulation of fermionic integrable systems

    SciTech Connect

    Das, A.; Huang, W.; Roy, S. )

    1991-10-01

    A fermionic Hamiltonian system is formulated on a supermanifold. It is shown that if the system possesses a bi-Hamiltonian structure, one can naturally define a Lax equation associated with a (1,1) tensor on this supermanifold and this allows one to construct a set of conserved quantities. Furthermore, if the corresponding Nijenhuis tensor vanishes, it is shown that all these conserved quantities would be in involution which is a sufficient condition for integrability of the system. The fermionic extension of the KdV equation with a bi-Hamiltonian structure within this geometrical approach is studied.

  6. Addressing System Reconfiguration and Incremental Integration within IMA Systems

    NASA Astrophysics Data System (ADS)

    Ferrero, F.; Rodríques, A. I.

    2009-05-01

    Recently space industry is paying special attention to Integrated Modular Avionics (IMA) systems due to the benefits that modular concepts could bring to the development of space applications, especially in terms of interoperability, flexibility and software reuse. Two important IMA goals to be highlighted are system reconfiguration, and incremental integration of new functionalities into a pre-existing system. The purpose of this paper is to show how system reconfiguration is conducted based on Allied Standard Avionics Architecture Council (ASAAC) concepts for IMA Systems. Besides, it aims to provide a proposal for addressing the incremental integration concept supported by our experience gained during European Technology Acquisition Program (ETAP) TDP1.7 programme. All these topics will be discussed taking into account safety issues and showing the blueprint as an appropriate technique to support these concepts.

  7. The Integrated Space Weather Analysis System

    NASA Astrophysics Data System (ADS)

    Maddox, M. M.; Mullinix, R. E.; Jain, P.; Berrios, D.; Hesse, M.; Rastaetter, L.; MacNeice, P. J.; Kuznetsova, M. M.; Taktakishvili, A.; Garneau, J. W.; Conti-Vock, J.

    2009-12-01

    The Integrated Space Weather Analysis System is a joint development project at NASA GSFC between the Space Weather Laboratory, Community Coordinated Modeling Center, Applied Engineering & Technology Directorate, and NASA HQ Office Of Chief Engineer. The iSWA system is a turnkey, web-based dissemination system for NASA-relevant space weather information that combines forecasts based on the most advanced space weather models with concurrent space environment information. A key design driver for the iSWA system is to generate and present vast amounts of space weather resources in an intuitive, user-configurable, and adaptable format - thus enabling users to respond to current and future space weather impacts as well as enabling post-imact analysis. This presentation will highlight several technical aspects of the iSWA system implementation including data collection methods, database design, customizable user interfaces, interactive system components, and innovative displays of quantitative information.

  8. Social network diversity and white matter microstructural integrity in humans.

    PubMed

    Molesworth, Tara; Sheu, Lei K; Cohen, Sheldon; Gianaros, Peter J; Verstynen, Timothy D

    2015-09-01

    Diverse aspects of physical, affective and cognitive health relate to social integration, reflecting engagement in social activities and identification with diverse roles within a social network. However, the mechanisms by which social integration interacts with the brain are unclear. In healthy adults (N = 155), we tested the links between social integration and measures of white matter microstructure using diffusion tensor imaging. Across the brain, there was a predominantly positive association between a measure of white matter integrity, fractional anisotropy (FA), and social network diversity. This association was particularly strong in a region near the anterior corpus callosum and driven by a negative association with the radial component of the diffusion signal. This callosal region contained projections between bilateral prefrontal cortices, as well as cingulum and corticostriatal pathways. FA within this region was weakly associated with circulating levels of the inflammatory cytokine interleukin-6 (IL-6), but IL-6 did not mediate the social network and FA relationship. Finally, variation in FA indirectly mediated the relationship between social network diversity and intrinsic functional connectivity of medial corticostriatal pathways. These findings suggest that social integration relates to myelin integrity in humans, which may help explain the diverse aspects of health affected by social networks. PMID:25605966

  9. Integrated monitoring and surveillance system demonstration project

    SciTech Connect

    Aumeier, S.E.; Walters, G.; Kotter, D.; Walrath, W.M.; Zamecnik, R.J.

    1997-07-01

    We present a summary of efforts associated with the installation of an integrated system for the surveillance and monitoring of stabilized plutonium metals and oxides in long-term storage. The product of this effort will include a Pu storage requirements document, baseline integrated monitoring and surveillance system (IMSS) prototype and test bed that will be installed in the Fuel Manufacturing Facility (FMF) nuclear material vault at Argonne National Laboratory - West (ANL-W), and a Pu tracking database including data analysis capabilities. The prototype will be based on a minimal set of vault and package monitoring requirements as derived from applicable DOE documentation and guidelines, detailed in the requirements document, including DOE-STD-3013-96. The use of standardized requirements will aid individual sites in the selection of sensors that best suit their needs while the prototype IMSS, located at ANL-W, will be used as a test bed to compare and contrast sensor performance against a baseline integrated system (the IMSS), demonstrate system capabilities, evaluate potential technology gaps, and test new hardware and software designs using various storage configurations. With efforts currently underway to repackage and store a substantial quantity of plutonium and plutonium-bearing material within the DOE complex, this is an opportune time to undertake such a project. 4 refs.

  10. Information survey for microcomputer systems integration

    SciTech Connect

    Hake, K.A.

    1991-12-01

    One goal of the PM-AIM is to provide US Army Project Managers (PMs) and Project Executive Officers (PEOs) with a fundamental microcomputing resource to help perform acquisition information management and its concomitant reporting requirements. Providing key application software represents one means of accomplishing this goal. This workstation would furnish a broad range of capabilities needed in the PM and PEO office settings as well as software tools for specific project management and acquisition information. Although still in the conceptual phase, the practical result of this exercise in systems integration will likely be a system called the Project Manager's Information System (PMIS) or the AIM workstation. It would include such software as, Project Manager's System Software (PMSS), Defense Acquisition Executive Summary (DAES), and Consolidated Acquisition Reporting System (CARS) and would conform to open systems architecture as accepted by the Department of Defense. ORNL has assisted PM-AIM in the development of technology ideas for the PMIS workstation concept. This paper represents the compilation of information gained during this process. This information is presented as a body of knowledge (or knowledge domain) defining the complex technology of microcomputing. The concept of systems integration or tying together all hardware and software components reflects the nature of PM-AIM's task in attempting to field a PMIS or AIM workstation.

  11. Information survey for microcomputer systems integration

    SciTech Connect

    Hake, K.A.

    1991-12-01

    One goal of the PM-AIM is to provide US Army Project Managers (PMs) and Project Executive Officers (PEOs) with a fundamental microcomputing resource to help perform acquisition information management and its concomitant reporting requirements. Providing key application software represents one means of accomplishing this goal. This workstation would furnish a broad range of capabilities needed in the PM and PEO office settings as well as software tools for specific project management and acquisition information. Although still in the conceptual phase, the practical result of this exercise in systems integration will likely be a system called the Project Manager`s Information System (PMIS) or the AIM workstation. It would include such software as, Project Manager`s System Software (PMSS), Defense Acquisition Executive Summary (DAES), and Consolidated Acquisition Reporting System (CARS) and would conform to open systems architecture as accepted by the Department of Defense. ORNL has assisted PM-AIM in the development of technology ideas for the PMIS workstation concept. This paper represents the compilation of information gained during this process. This information is presented as a body of knowledge (or knowledge domain) defining the complex technology of microcomputing. The concept of systems integration or tying together all hardware and software components reflects the nature of PM-AIM`s task in attempting to field a PMIS or AIM workstation.

  12. Integrated Reliability and Risk Analysis System (IRRAS)

    SciTech Connect

    Russell, K D; McKay, M K; Sattison, M.B. Skinner, N.L.; Wood, S T; Rasmuson, D M

    1992-01-01

    The Integrated Reliability and Risk Analysis System (IRRAS) is a state-of-the-art, microcomputer-based probabilistic risk assessment (PRA) model development and analysis tool to address key nuclear plant safety issues. IRRAS is an integrated software tool that gives the user the ability to create and analyze fault trees and accident sequences using a microcomputer. This program provides functions that range from graphical fault tree construction to cut set generation and quantification. Version 1.0 of the IRRAS program was released in February of 1987. Since that time, many user comments and enhancements have been incorporated into the program providing a much more powerful and user-friendly system. This version has been designated IRRAS 4.0 and is the subject of this Reference Manual. Version 4.0 of IRRAS provides the same capabilities as Version 1.0 and adds a relational data base facility for managing the data, improved functionality, and improved algorithm performance.

  13. An integrated system for genetic analysis

    PubMed Central

    Fiddy, Simon; Cattermole, David; Xie, Dong; Duan, Xiao Yuan; Mott, Richard

    2006-01-01

    Background Large-scale genetic mapping projects require data management systems that can handle complex phenotypes and detect and correct high-throughput genotyping errors, yet are easy to use. Description We have developed an Integrated Genotyping System (IGS) to meet this need. IGS securely stores, edits and analyses genotype and phenotype data. It stores information about DNA samples, plates, primers, markers and genotypes generated by a genotyping laboratory. Data are structured so that statistical genetic analysis of both case-control and pedigree data is straightforward. Conclusion IGS can model complex phenotypes and contain genotypes from whole genome association studies. The database makes it possible to integrate genetic analysis with data curation. The IGS web site contains further information. PMID:16623936

  14. ITER Construction--Plant System Integration

    SciTech Connect

    Tada, E.; Matsuda, S.

    2009-02-19

    This brief paper introduces how the ITER will be built in the international collaboration. The ITER Organization plays a central role in constructing ITER and leading it into operation. Since most of the ITER components are to be provided in-kind from the member countries, integral project management should be scoped in advance of real work. Those include design, procurement, system assembly, testing, licensing and commissioning of ITER.

  15. Integrated soldier power and data system (ISPDS)

    NASA Astrophysics Data System (ADS)

    Ostroumov, Roman; Forrester, Thomas; Lee, Kang; Stephens, Robert; Lai, Anthony; Zahzah, Mohamad

    2014-06-01

    Physical Optics Corporation (POC) developed the body-worn Integrated Soldier Power and Data System (ISPDS), a configurable node for plug-in wired or wireless server/client or peer-to-peer computing with accommodations for power, sensor I/O interfaces, and energy harvesting. The enabling technology increases the efficacy of uniformed personnel and first responders and provides an option for reducing force structure associated with the need for hardware network infrastructure to enable a mobile digital communications architecture for dismounted troops. The ISPDS system addresses the DoD's need for an "intelligent" power control system in an effort to increase mission duration and maximize the first responders and warfighter's effectiveness without concern for the available energy resources (i.e., batteries). ISPDS maximizes durability and survivability, assesses influences that affect performance, and provides the network backbone and mobile node hardware. POC is producing two vest-integrated variants, one each for the U.S. Army PEO Ground Soldier and the Air Soldier, with each including state-of-the-art low-profile and robust wearable connectors, cabling, and harnesses, and an integrated low-profile power manager and conformal battery for data and power distribution. The innovative intelligent power controller (IPC), in the form of the ISPDS firmware and power sensing and control electronics, will enable ISPDS to optimize power levels both automatically and in accordance with manually set preferences. The IPC module is power dense and efficient, and adaptively provides lossless transfer of available harvested photovoltaic energy to the battery. The integrated systems were tested for suitable electrical, electromagnetic interference (EMI), and environmental performance as outlined in military standards such as MIL-STD- 810G and MIL STD-461F.

  16. Making Technology Ready: Integrated Systems Health Management

    NASA Technical Reports Server (NTRS)

    Malin, Jane T.; Oliver, Patrick J.

    2007-01-01

    This paper identifies work needed by developers to make integrated system health management (ISHM) technology ready and by programs to make mission infrastructure ready for this technology. This paper examines perceptions of ISHM technologies and experience in legacy programs. Study methods included literature review and interviews with representatives of stakeholder groups. Recommendations address 1) development of ISHM technology, 2) development of ISHM engineering processes and methods, and 3) program organization and infrastructure for ISHM technology evolution, infusion and migration.

  17. Integrated System Test of an Airbreathing Rocket

    NASA Technical Reports Server (NTRS)

    Mack, Gregory; Beaudry, Charles; Ketchum, Andrew; McArthur, J. Craig (Technical Monitor)

    2002-01-01

    This viewgraph presentation provides information on NASA's attempts to develop an air-breathing propulsion in an effort to make future space transportation safer, more reliable and significantly less expensive than today's missions. Spacecraft powered by air-breathing rocket engines would be completely reusable, able to take off and land at airport runways and ready to fly again within days. A radical new engine project is called the Integrated System Tests of an Air-breathing Rocket, or ISTAR.

  18. Note on quantum groups and integrable systems

    NASA Astrophysics Data System (ADS)

    Popolitov, A.

    2016-01-01

    The free-field formalism for quantum groups [preprint ITEP-M3/94, CRM-2202 hep-th/9409093] provides a special choice of coordinates on a quantum group. In these coordinates the construction of associated integrable system [arXiv:1207.1869] is especially simple. This choice also fits into general framework of cluster varieties [math.AG/0311245]—natural changes in coordinates are cluster mutations.

  19. System design and integration analysis for the Integrated Booking System (IBS)

    SciTech Connect

    Truett, L.F.; Wheeler, V.V.; Grubb, J.W.; Grubb, J.W.; Faby, E.Z.

    1995-11-01

    In accordance with tasking for the Military Traffic Management Command (MTMC), the Oak Ridge National Laboratory (ORNL) investigated design and integration issues and identified specific options for MTMC`s Integrated Booking System (IBS). Three system designs are described: the single-server, stand-alone IBS; the area-based IBS; and the fully-integrated IBS. Because of the functional and technical requirements of IBS and because of the MTMC strategy of sharing resources, ORNL recommends the fully-integrated design. This option uses the excess computing resources provided through the architectural components of the Integrated Cargo Database (ICDB) and provides visibility over the cargo record from initial request through final delivery.

  20. Integrated Robot-Human Control in Mining Operations

    SciTech Connect

    George Danko

    2007-09-30

    This report contains a detailed description of the work conducted for the project on Integrated Robot-Human Control in Mining Operations at University of Nevada, Reno. This project combines human operator control with robotic control concepts to create a hybrid control architecture, in which the strengths of each control method are combined to increase machine efficiency and reduce operator fatigue. The kinematics reconfiguration type differential control of the excavator implemented with a variety of 'software machine kinematics' is the key feature of the project. This software re-configured excavator is more desirable to execute a given digging task. The human operator retains the master control of the main motion parameters, while the computer coordinates the repetitive movement patterns of the machine links. These repetitive movements may be selected from a pre-defined family of trajectories with different transformations. The operator can make adjustments to this pattern in real time, as needed, to accommodate rapidly-changing environmental conditions. A working prototype has been developed using a Bobcat 435 excavator. The machine is operational with or without the computer control system depending on whether the computer interface is on or off. In preparation for emulated mining tasks tests, typical, repetitive tool trajectories during surface mining operations were recorded at the Newmont Mining Corporation's 'Lone Tree' mine in Nevada. Analysis of these working trajectories has been completed. The motion patterns, when transformed into a family of curves, may serve as the basis for software-controlled machine kinematics transformation in the new human-robot control system. A Cartesian control example has been developed and tested both in simulation and on the experimental excavator. Open-loop control is robustly stable and free of short-term dynamic problems, but it allows for drifting away from the desired motion kinematics of the machine. A novel, closed

  1. System specification for the integrated monitoring and surveillance system

    SciTech Connect

    1997-09-01

    This System Specification establishes the requirements for the Plutonium Focus Area (PFA) Integrated Monitoring and Surveillance System (IMSS). In this document, ``Integrated Monitoring and Surveillance System`` is used to describe the concept of integrated sensors, computers, personnel, and systems that perform the functions of sensing conditions, acquiring data, monitoring environmental safety and health, controlling and accounting for materials, monitoring material stability, monitoring container integrity, transferring data, and analyzing, reporting, and storing data. This concept encompasses systems (e.g. sensors, personnel, databases, etc.) that are already in place at the sites but may require modifications or additions to meet all identified surveillance requirements. The purpose of this System Specification is to provide Department of Energy (DOE) sites that store plutonium materials with a consolidation of all known requirements for the storage and surveillance of 3013 packages of stabilized plutonium metals and oxides. This compilation may be used (1) as a baseline for surveillance system design specifications where 3013 packages of stabilized plutonium metals and oxides will be stored and monitored; (2) as a checklist for evaluating existing surveillance systems to ensure that all requirements are met for the storage and surveillance of 3013 packages of stabilized plutonium metals and oxides; and (3) as a baseline for preparing procurement specifications tailored for site specific storage and surveillance of 3013 packages of stabilized plutonium metals and oxides.

  2. Toward an integrated system of clade names.

    PubMed

    de Queiroz, Kevin

    2007-12-01

    Although the proposition that higher taxa should correspond to clades is widely accepted, current nomenclature does not distinguish clearly between different clades in nested series. In particular, the same name is often applied to a total clade, its crown clade, and clades originating with various nodes, branches, and apomorphies in between. An integrated system of clade names is described based on categories of clades defined with respect to lineages that have survived to the present time. In this system, the most widely known names are applied to crown clades, the names of total clades are formed by adding a standard prefix to the names of the corresponding crowns, and the names of apomorphy clades describe the specific apomorphies with which they originated. Relative to traditional approaches, this integrated approach to naming clades is both more precise concerning the associations of names with particular clades and more efficient with regard to the cognitive effort required to recognize the names of corresponding crown and total clades. It also seems preferable to five alternatives that could be used to make the same distinctions. The integrated system of clade names has several advantages, including the facilitation of communication among biologists who study distantly related clades, promoting a broader conceptualization of the origins of distinctive clades of extant organisms and emphasizing the continuous nature of evolution. PMID:18066930

  3. Overview of integrative tools and methods in assessing ecological integrity in estuarine and coastal systems worldwide.

    PubMed

    Borja, Angel; Bricker, Suzanne B; Dauer, Daniel M; Demetriades, Nicolette T; Ferreira, João G; Forbes, Anthony T; Hutchings, Pat; Jia, Xiaoping; Kenchington, Richard; Carlos Marques, João; Zhu, Changbo

    2008-09-01

    In recent years, several sets of legislation worldwide (Oceans Act in USA, Australia or Canada; Water Framework Directive or Marine Strategy in Europe, National Water Act in South Africa, etc.) have been developed in order to address ecological quality or integrity, within estuarine and coastal systems. Most such legislation seeks to define quality in an integrative way, by using several biological elements, together with physico-chemical and pollution elements. Such an approach allows assessment of ecological status at the ecosystem level ('ecosystem approach' or 'holistic approach' methodologies), rather than at species level (e.g. mussel biomonitoring or Mussel Watch) or just at chemical level (i.e. quality objectives) alone. Increasing attention has been paid to the development of tools for different physico-chemical or biological (phytoplankton, zooplankton, benthos, algae, phanerogams, fishes) elements of the ecosystems. However, few methodologies integrate all the elements into a single evaluation of a water body. The need for such integrative tools to assess ecosystem quality is very important, both from a scientific and stakeholder point of view. Politicians and managers need information from simple and pragmatic, but scientifically sound methodologies, in order to show to society the evolution of a zone (estuary, coastal area, etc.), taking into account human pressures or recovery processes. These approaches include: (i) multidisciplinarity, inherent in the teams involved in their implementation; (ii) integration of biotic and abiotic factors; (iii) accurate and validated methods in determining ecological integrity; and (iv) adequate indicators to follow the evolution of the monitored ecosystems. While some countries increasingly use the establishment of marine parks to conserve marine biodiversity and ecological integrity, there is awareness (e.g. in Australia) that conservation and management of marine ecosystems cannot be restricted to Marine Protected

  4. Intelligent Sensors: An Integrated Systems Approach

    NASA Technical Reports Server (NTRS)

    Mahajan, Ajay; Chitikeshi, Sanjeevi; Bandhil, Pavan; Utterbach, Lucas; Figueroa, Fernando

    2005-01-01

    The need for intelligent sensors as a critical component for Integrated System Health Management (ISHM) is fairly well recognized by now. Even the definition of what constitutes an intelligent sensor (or smart sensor) is well documented and stems from an intuitive desire to get the best quality measurement data that forms the basis of any complex health monitoring and/or management system. If the sensors, i.e. the elements closest to the measurand, are unreliable then the whole system works with a tremendous handicap. Hence, there has always been a desire to distribute intelligence down to the sensor level, and give it the ability to assess its own health thereby improving the confidence in the quality of the data at all times. This paper proposes the development of intelligent sensors as an integrated systems approach, i.e. one treats the sensors as a complete system with its own sensing hardware (the traditional sensor), A/D converters, processing and storage capabilities, software drivers, self-assessment algorithms, communication protocols and evolutionary methodologies that allow them to get better with time. Under a project being undertaken at the NASA Stennis Space Center, an integrated framework is being developed for the intelligent monitoring of smart elements. These smart elements can be sensors, actuators or other devices. The immediate application is the monitoring of the rocket test stands, but the technology should be generally applicable to the Intelligent Systems Health Monitoring (ISHM) vision. This paper outlines some fundamental issues in the development of intelligent sensors under the following two categories: Physical Intelligent Sensors (PIS) and Virtual Intelligent Sensors (VIS).

  5. Integrated Neural Flight and Propulsion Control System

    NASA Technical Reports Server (NTRS)

    Kaneshige, John; Gundy-Burlet, Karen; Norvig, Peter (Technical Monitor)

    2001-01-01

    This paper describes an integrated neural flight and propulsion control system. which uses a neural network based approach for applying alternate sources of control power in the presence of damage or failures. Under normal operating conditions, the system utilizes conventional flight control surfaces. Neural networks are used to provide consistent handling qualities across flight conditions and for different aircraft configurations. Under damage or failure conditions, the system may utilize unconventional flight control surface allocations, along with integrated propulsion control, when additional control power is necessary for achieving desired flight control performance. In this case, neural networks are used to adapt to changes in aircraft dynamics and control allocation schemes. Of significant importance here is the fact that this system can operate without emergency or backup flight control mode operations. An additional advantage is that this system can utilize, but does not require, fault detection and isolation information or explicit parameter identification. Piloted simulation studies were performed on a commercial transport aircraft simulator. Subjects included both NASA test pilots and commercial airline crews. Results demonstrate the potential for improving handing qualities and significantly increasing survivability rates under various simulated failure conditions.

  6. Integrated microfluidic systems for DNA analysis.

    PubMed

    Njoroge, Samuel K; Chen, Hui-Wen; Witek, Małgorzata A; Soper, Steven A

    2011-01-01

    The potential utility of genome-related research in terms of evolving basic discoveries in biology has generated widespread use of DNA diagnostics and DNA forensics and driven the accelerated development of fully integrated microfluidic systems for genome processing. To produce a microsystem with favorable performance characteristics for genetic-based analyses, several key operational elements must be strategically chosen, including device substrate material, temperature control, fluidic control, and reaction product readout. As a matter of definition, a microdevice is a chip that performs a single processing step, for example microchip electrophoresis. Several microdevices can be integrated to a single wafer, or combined on a control board as separate devices to form a microsystem. A microsystem is defined as a chip composed of at least two microdevices. Among the many documented analytical microdevices, those focused on the ability to perform the polymerase chain reaction (PCR) have been reported extensively due to the importance of this processing step in most genetic-based assays. Other microdevices that have been detailed in the literature include those for solid-phase extractions, microchip electrophoresis, and devices composed of DNA microarrays used for interrogating DNA primary structure. Great progress has also been made in the areas of chip fabrication, bonding and sealing to enclose fluidic networks, evaluation of different chip substrate materials, surface chemistries, and the architecture of reaction conduits for basic processing steps such as mixing. Other important elements that have been developed to realize functional systems include miniaturized readout formats comprising optical or electrochemical transduction and interconnect technologies. These discoveries have led to the development of fully autonomous and functional integrated systems for genome processing that can supply "sample in/answer out" capabilities. In this chapter, we focus on

  7. Integration of the TDWR and LLWAS wind shear detection system

    NASA Technical Reports Server (NTRS)

    Cornman, Larry

    1991-01-01

    Operational demonstrations of a prototype TDWR/LLWAS (Terminal Doppler Weather Radar/Low Level Wind shear Alarm System) integrated wind shear detection system were conducted. The integration of wind shear detection systems is needed to provide end-users with a single, consensus source of information. A properly implemented integrated system provides wind shear warnings of a higher quality than stand-alone LLWAS or TDWR systems. The algorithmic concept used to generate the TDWR/LLWAS integrated products and several case studies are discussed, indicating the viability and potential of integrated wind shear detection systems. Implications for integrating ground and airborne wind shear detection systems are briefly examined.

  8. Opportunities for Launch Site Integrated System Health Engineering and Management

    NASA Technical Reports Server (NTRS)

    Waterman, Robert D.; Langwost, Patricia E.; Waterman, Susan J.

    2005-01-01

    The launch site processing flow involves operations such as functional verification, preflight servicing and launch. These operations often include hazards that must be controlled to protect human life and critical space hardware assets. Existing command and control capabilities are limited to simple limit checking durig automated monitoring. Contingency actions are highly dependent on human recognition, decision making, and execution. Many opportunities for Integrated System Health Engineering and Management (ISHEM) exist throughout the processing flow. This paper will present the current human-centered approach to health management as performed today for the shuttle and space station programs. In addition, it will address some of the more critical ISHEM needs, and provide recommendations for future implementation of ISHEM at the launch site.

  9. Integrating a geographic information system, a scientific visualization system, and a precipitation model

    USGS Publications Warehouse

    Hay, L.E.; Knapp, L.K.

    1996-01-01

    Investigating natural, potential, and human-induced impacts on hydrologic systems commonly requires complex modeling with overlapping data requirements, plus massive amounts of one- to four-dimensional data at multiple scales and formats. Given the complexity of most hydrologic studies, the requisite software infrastructure must incorporate many components including simulation modeling and spatial analysis with a flexible, intuitive display. Integrating geographic information systems (GIS) and scientific visualization systems (SVS) provides such an infrastructure. This paper describes an integrated system consisting of an orographic precipitation model, a GIS, and an SVS. The results of this study provide a basis for improving the understanding of hydro-climatic processes in mountainous regions. An additional benefit of the integrated system, the value of which is often underestimated, is the improved ability to communicate model results, leading to a broader understanding of the model assumptions, sensitivities, and conclusions at a management level.Investigating natural, potential, and human-induced impacts on hydrologic systems commonly requires complex modeling with overlapping data requirements, plus massive amounts of one- to four-dimensional data at multiple scales and formats. Given the complexity of most hydrologic studies, the requisite software infrastructure must incorporate many components including simulation modeling and spatial analysis with a flexible, intuitive display. Integrating geographic information systems (GIS) and scientific visualization systems (SVS) provides such an infrastructure. This paper describes an integrated system consisting of an orographic precipitation model, a GIS, and an SVS. The results of this study provide a basis for improving the understanding of hydro-climatic processes in mountainous regions. An additional benefit of the integrated system, the value of which is often underestimated, is the improved ability to

  10. An Integrated Health Monitoring System for Fission Surface Power

    NASA Astrophysics Data System (ADS)

    Hashemian, H. M.; Shumaker, B. D.; McCulley, J. R.; Morton, G. W.

    Based on such criteria as safety and mission success, programmatic risk, affordability, and extensibility/flexibility, the National Aeronautics and Space Administration (NASA) has chosen fission surface power (FSP) as the primary energy source for building a sustained human presence on the Moon, exploring Mars, and extremely long-duration space missions. The current benchmark FSP system has a mission life of at least 8 years during which time there is no opportunity for repair, sensor calibrations, or periodic maintenance tasks that are normally performed on terrestrial-based nuclear power plants during scheduled outages. Current technology relies heavily on real-time human interaction, monitoring and control. However; due to the long communication times between the Earth and Moon, or Mars, real-time human control is not possible, resulting in a critical need to develop autonomous health monitoring technology for FSP systems.This paper describes the design and development of an autonomous health monitoring system that will (1) provide on-line calibration monitoring, (2) reduce uncertainties in sensor measurements, and (3) provide sensor validation and fault detection capabilities for the control systems of various FSP subsystems. The health monitoring system design integrates a number of signal processing algorithms and techniques such as cross-calibration, empirical modeling using neural networks, and physical modeling under a modular signal processing platform that will enable robust sensor and system monitoring without the need for human interaction. Prototypes of the health monitoring system have been tested and validated on data acquired from preliminary subsystem testing of NASA's FSP Technology Demonstration Unit (TDU) as well as simulated laboratory data. Results from this testing have demonstrated the utility and benefits that such autonomous health monitoring systems can provide to FSP subsystems and other potential applications within NASA such as launch

  11. Orion ECLSS/Suit System Intermediate Pressure Integrated Suit Test

    NASA Technical Reports Server (NTRS)

    Barido, Richard A.

    2014-01-01

    The Intermediate Pressure Integrated Suit Test (IPIST) phase of the integrated system testing of the Orion Vehicle Atmosphere Revitalization System (ARS) technology was conducted for the Multipurpose Crew Vehicle (MPCV) Program within the National Aeronautics and Space Administration (NASA) Exploration Systems Mission Directorate. This test was performed in the eleven-foot human-rated vacuum chamber at the NASA Johnson Space Center by the Crew and Thermal Systems Division. This testing is the second phase of suit loop testing to demonstrate the viability of the Environmental Control and Life Support System (ECLSS) being developed for Orion. The IPIST configuration consisted of development hardware that included the CAMRAS, air revitalization loop fan and suit loop regulator. Two test subjects were in pressure suits at varying suit pressures. Follow-on testing, to be conducted in 2014, will utilize the same hardware with human test subjects in pressure suits at vacuum. This paper will discuss the results and findings of IPIST and will also discuss future testing.

  12. Systems Engineering and Integration (SE and I)

    NASA Technical Reports Server (NTRS)

    Chevers, ED; Haley, Sam

    1990-01-01

    The issue of technology advancement and future space transportation vehicles is addressed. The challenge is to develop systems which can be evolved and improved in small incremental steps where each increment reduces present cost, improves, reliability, or does neither but sets the stage for a second incremental upgrade that does. Future requirements are interface standards for commercial off the shelf products to aid in the development of integrated facilities; enhanced automated code generation system slightly coupled to specification and design documentation; modeling tools that support data flow analysis; and shared project data bases consisting of technical characteristics cast information, measurement parameters, and reusable software programs. Topics addressed include: advanced avionics development strategy; risk analysis and management; tool quality management; low cost avionics; cost estimation and benefits; computer aided software engineering; computer systems and software safety; system testability; and advanced avionics laboratories - and rapid prototyping. This presentation is represented by viewgraphs only.

  13. Pacs: Part Of An Integrated Communications System

    NASA Astrophysics Data System (ADS)

    Thompson, B. G.; Brenton, Bradley C.; Staab, Edward V.; Perry, J. Randolph; Parrish, Denise; Johnston, R. Eugene; Creasy, Jeffrey L.

    1985-09-01

    The Department of Radiology at the University of North Carolina-Chapel Hill (UNC) has developed the concept for an integrated picture archiving and communications system. A communications network has been installed, and computer facilities are being interfaced within radiology areas. Other projects include the establishment of a computer simulation model of departmental operations and assembly of a limited picture archival and communication system (PACS) beginning with the CT and NMR Modalities. While this approach may provide immediate clinical benefits, the initial thrust has been towards evaluation of prototype systems with flexibility for modifications. PACS operational parameters are being studied for their acceptability in support of radiology clinical services. The goal is to provide objective operational data as a basis for planning system improvements.

  14. The Modular Integrated Video System (MIVS)

    NASA Astrophysics Data System (ADS)

    Schneider, S. L.; Sonnier, C. S.

    The Modular Integrated Video System (MIVS) is being developed for the International Atomic Energy Agency (IAEA) for use in facilities where mains power is available and the separation of the Camera and Recording Control Unit is desirable. The system is being developed under the US Program for Technical Assistance to the IAEA Safeguards (POTAS). The MIVS is designed to be a user friendly system allowing operation with minimal effort and training. The system software, through the use of a Liquid Crystal Display (LCD) and four soft keys, leads the inspector through the setup procedures to accomplish the intended surveillance or maintenance task. Review of surveillance data is accomplished with the use of a Portable Review Station. This Review Station will aid the inspector in the review process and determine the number of missed video scenes during a surveillance period.

  15. An integrated radiation physics computer code system.

    NASA Technical Reports Server (NTRS)

    Steyn, J. J.; Harris, D. W.

    1972-01-01

    An integrated computer code system for the semi-automatic and rapid analysis of experimental and analytic problems in gamma photon and fast neutron radiation physics is presented. Such problems as the design of optimum radiation shields and radioisotope power source configurations may be studied. The system codes allow for the unfolding of complex neutron and gamma photon experimental spectra. Monte Carlo and analytic techniques are used for the theoretical prediction of radiation transport. The system includes a multichannel pulse-height analyzer scintillation and semiconductor spectrometer coupled to an on-line digital computer with appropriate peripheral equipment. The system is geometry generalized as well as self-contained with respect to material nuclear cross sections and the determination of the spectrometer response functions. Input data may be either analytic or experimental.

  16. Integration of genomic and medical data into a 3D atlas of human anatomy.

    PubMed

    Turinsky, Andrei L; Fanea, Elena; Trinh, Quang; Dong, Xiaoli; Stromer, Julie N; Shu, Xueling; Wat, Stephen; Hallgrímsson, Benedikt; Hill, Jonathan W; Edwards, Carol; Grosenick, Brenda; Yajima, Masumi; Sensen, Christoph W

    2008-01-01

    We have developed a framework for the visual integration and exploration of multi-scale biomedical data, which includes anatomical and molecular components. We have also created a Java-based software system that integrates molecular information, such as gene expression data, into a three-dimensional digital atlas of the male adult human anatomy. Our atlas is structured according to the Terminologia Anatomica. The underlying data-indexing mechanism uses open standards and semantic ontology-processing tools to establish the associations between heterogeneous data types. The software system makes an extensive use of virtual reality visualization. PMID:18391362

  17. Enhanced integrated nonthermal treatment system study

    SciTech Connect

    Biagi, C.; Schwinkendorf, B.; Teheranian, B.

    1997-02-01

    The purpose of the Enhanced Nonthermal Treatment Systems (ENTS) study is to evaluate alternative configurations of one of the five systems evaluated in the Integrated Nonthermal Treatment Systems (INTS) study. Five alternative configurations are evaluated. Each is designed to enhance the final waste form performance by replacing grout with improved stabilization technologies, or to improve system performance by improving the destruction efficiency for organic contaminants. AU enhanced systems are alternative configurations of System NT-5, which has the following characteristics: Nonthermal System NT-5: (1) catalytic wet oxidation (CWO) to treat organic material including organic liquids, sludges, and soft (or combustible) debris, (2) thermal desorption of inorganic sludge and process residue, (3) washing of soil and inorganic debris with treatment by CWO of removed organic material, (4) metal decontamination by abrasive blasting, (5) stabilization of treated sludge, soil, debris, and untreated debris with entrained contamination in grout, and (6) stabilization of inorganic sludge, salts and secondary waste in polymer. System NT-5 was chosen because it was designed to treat combustible debris thereby minimizing the final waste form volume, and because it uses grout for primary stabilization. The enhanced nonthermal systems were studied to determine the cost and performance impact of replacing grout (a commonly used stabilization agent in the DOE complex) with improved waste stabilization methods such as vitrification and polymer.

  18. Energy integrated farm system technical summary report

    SciTech Connect

    Breckenridge, R.P.; Price, D.R.; Sherwood, R.K.; Thompson, W.N.

    1987-03-01

    The Energy Integrated Farm System program was established by the Department of Energy in 1980 in response to the hardship imposed on US farmers by high fuel costs and unreliable fuel supplies. The program investigated the feasibility of integrating energy conservation practices with on-farm energy production to reduce farm energy consumption and make farms more energy self-sufficient. Seven farms located in various geographical regions in the US and Puerto Rico participated in the program. Each of these farms developed an energy integrated farm system project that used a unique combination of energy production and energy conservation methods to supply energy to the farm and reduce the farm's dependence on energy produced from nonrenewable sources such as coal and oil. Methods used at these projects included conservation tillage, solar heating, waste heat recovery, methane digestion, electricity production from biogas, alcohol fuel production, fluidized-bed combustion of crop wastes, and computer-aided conservation irrigation. This report is a summary of the seven technical manuals prepared at the conclusion of the projects. It presents highlights and results, provides an overview of successes and problems, and lists recommendations.

  19. Integrated forward osmosis-membrane distillation process for human urine treatment.

    PubMed

    Liu, Qianliang; Liu, Caihong; Zhao, Lei; Ma, Weichao; Liu, Huiling; Ma, Jun

    2016-03-15

    This study demonstrated a forward osmosis-membrane distillation (FO-MD) hybrid system for real human urine treatment. A series of NaCl solutions at different concentrations were adopted for draw solutions in FO process, which were also the feed solutions of MD process. To establish a stable and continuous integrated FO-MD system, individual FO process with different NaCl concentrations and individual direct contact membrane distillation (DCMD) process with different feed temperatures were firstly investigated separately. Four stable equilibrium conditions were obtained from matching the water transfer rates of individual FO and MD processes. It was found that the integrated system is stable and sustainable when the water transfer rate of FO subsystem is equal to that of MD subsystem. The rejections to main contaminants in human urine were also investigated. Although individual FO process had relatively high rejection to Total Organic Carbon (TOC), Total Nitrogen (TN) and Ammonium Nitrogen (NH4(+)-N) in human urine, these contaminants could also accumulate in draw solution after long term performance. The MD process provided an effective rejection to contaminants in draw solution after FO process and the integrated system revealed nearly complete rejection to TOC, TN and NH4(+)-N. This work provided a potential treatment process for human urine in some fields such as water regeneration in space station and water or nutrient recovery from source-separated urine. PMID:26773483

  20. Genic insights from integrated human proteomics in GeneCards.

    PubMed

    Fishilevich, Simon; Zimmerman, Shahar; Kohn, Asher; Iny Stein, Tsippi; Olender, Tsviya; Kolker, Eugene; Safran, Marilyn; Lancet, Doron

    2016-01-01

    GeneCards is a one-stop shop for searchable human gene annotations (http://www.genecards.org/). Data are automatically mined from ∼120 sources and presented in an integrated web card for every human gene. We report the application of recent advances in proteomics to enhance gene annotation and classification in GeneCards. First, we constructed the Human Integrated Protein Expression Database (HIPED), a unified database of protein abundance in human tissues, based on the publically available mass spectrometry (MS)-based proteomics sources ProteomicsDB, Multi-Omics Profiling Expression Database, Protein Abundance Across Organisms and The MaxQuant DataBase. The integrated database, residing within GeneCards, compares favourably with its individual sources, covering nearly 90% of human protein-coding genes. For gene annotation and comparisons, we first defined a protein expression vector for each gene, based on normalized abundances in 69 normal human tissues. This vector is portrayed in the GeneCards expression section as a bar graph, allowing visual inspection and comparison. These data are juxtaposed with transcriptome bar graphs. Using the protein expression vectors, we further defined a pairwise metric that helps assess expression-based pairwise proximity. This new metric for finding functional partners complements eight others, including sharing of pathways, gene ontology (GO) terms and domains, implemented in the GeneCards Suite. In parallel, we calculated proteome-based differential expression, highlighting a subset of tissues that overexpress a gene and subserving gene classification. This textual annotation allows users of VarElect, the suite's next-generation phenotyper, to more effectively discover causative disease variants. Finally, we define the protein-RNA expression ratio and correlation as yet another attribute of every gene in each tissue, adding further annotative information. The results constitute a significant enhancement of several Gene

  1. Genic insights from integrated human proteomics in GeneCards

    PubMed Central

    Fishilevich, Simon; Zimmerman, Shahar; Kohn, Asher; Iny Stein, Tsippi; Olender, Tsviya; Kolker, Eugene; Safran, Marilyn; Lancet, Doron

    2016-01-01

    GeneCards is a one-stop shop for searchable human gene annotations (http://www.genecards.org/). Data are automatically mined from ∼120 sources and presented in an integrated web card for every human gene. We report the application of recent advances in proteomics to enhance gene annotation and classification in GeneCards. First, we constructed the Human Integrated Protein Expression Database (HIPED), a unified database of protein abundance in human tissues, based on the publically available mass spectrometry (MS)-based proteomics sources ProteomicsDB, Multi-Omics Profiling Expression Database, Protein Abundance Across Organisms and The MaxQuant DataBase. The integrated database, residing within GeneCards, compares favourably with its individual sources, covering nearly 90% of human protein-coding genes. For gene annotation and comparisons, we first defined a protein expression vector for each gene, based on normalized abundances in 69 normal human tissues. This vector is portrayed in the GeneCards expression section as a bar graph, allowing visual inspection and comparison. These data are juxtaposed with transcriptome bar graphs. Using the protein expression vectors, we further defined a pairwise metric that helps assess expression-based pairwise proximity. This new metric for finding functional partners complements eight others, including sharing of pathways, gene ontology (GO) terms and domains, implemented in the GeneCards Suite. In parallel, we calculated proteome-based differential expression, highlighting a subset of tissues that overexpress a gene and subserving gene classification. This textual annotation allows users of VarElect, the suite’s next-generation phenotyper, to more effectively discover causative disease variants. Finally, we define the protein–RNA expression ratio and correlation as yet another attribute of every gene in each tissue, adding further annotative information. The results constitute a significant enhancement of several Gene

  2. Integrated Formation Optical Communication and Estimation System

    NASA Technical Reports Server (NTRS)

    Scharf, Daniel; Kuhnert, Andreas; Kovalik, Joseph; Hadaegh, Fred; Shaddock, Daniel

    2008-01-01

    An architecture has been designed that integrates formation estimation methodologies, precision formation sensing, and high-bandwidth formation communication into a robust, strap-on system that meets knowledge and communication requirements for the majority of planned, precision formation missions. Specifically, the integrated system supports (a) sub-millimeter metrology, (b) multiple greater than 10 Mbps communication channels over a large, 10 deg field-of-view (FOV), and (c) generalized formation estimation methodologies. The sensing sub-system consists of several absolute, metrology gauges with up to 0.1 mm precision that use amplitude-modulated lasers and a LISA-heritage phase meter. Since amplitude modulation is used, inexpensive and robust diode lasers may be used instead of complex, frequency-stabilized lasers such as for nanometer-level metrology. The metrology subsystem laser transceivers consist of a laser diode, collecting optics, and an avalanche photo diode (APD) for detecting incoming laser signals. The APD is necessary since received power is small due to the large (for optical applications) FOV. The phase meter determines the phase of the incoming amplitude modulations as measured by the APD. This phase is equivalent to time-of-flight and, therefore, distance. By placing three laser transceivers on each spacecraft, 18 clock-offset-corrupted distances are calculated. These measurements are communicated and averaged to obtain nine correct distances between the transceivers. From these correct distances, the range and bearing between spacecraft and their relative attitude are determined. Next, communication is integrated on the laser carrier through spectral separation. Metrology amplitude modulations are limited to the 45-50 MHz band, leaving 0-45 MHz for communication. Through careful design of coding scheme, error correction, and filters, six independent 10 Mbps receive channels are possible. Hence, a spacecraft can simultaneously broadcast at 10

  3. Integrated Systems Health Management for Space Exploration

    NASA Technical Reports Server (NTRS)

    Uckun, Serdar

    2005-01-01

    Integrated Systems Health Management (ISHM) is a system engineering discipline that addresses the design, development, operation, and lifecycle management of components, subsystems, vehicles, and other operational systems with the purpose of maintaining nominal system behavior and function and assuring mission safety and effectiveness under off-nominal conditions. NASA missions are often conducted in extreme, unfamiliar environments of space, using unique experimental spacecraft. In these environments, off-nominal conditions can develop with the potential to rapidly escalate into mission- or life-threatening situations. Further, the high visibility of NASA missions means they are always characterized by extraordinary attention to safety. ISHM is a critical element of risk mitigation, mission safety, and mission assurance for exploration. ISHM enables: In-space maintenance and repair; a) Autonomous (and automated) launch abort and crew escape capability; b) Efficient testing and checkout of ground and flight systems; c) Monitoring and trending of ground and flight system operations and performance; d) Enhanced situational awareness and control for ground personnel and crew; e) Vehicle autonomy (self-sufficiency) in responding to off-nominal conditions during long-duration and distant exploration missions; f) In-space maintenance and repair; and g) Efficient ground processing of reusable systems. ISHM concepts and technologies may be applied to any complex engineered system such as transportation systems, orbital or planetary habitats, observatories, command and control systems, life support systems, safety-critical software, and even the health of flight crews. As an overarching design and operational principle implemented at the system-of-systems level, ISHM holds substantial promise in terms of affordability, safety, reliability, and effectiveness of space exploration missions.

  4. Systems integration of lunar Campsite vehicles

    NASA Technical Reports Server (NTRS)

    Capps, Stephen; Ruff, Theron

    1992-01-01

    This paper describes the configuration design and subsystems integration resolution for lunar Campsite vehicles and the crew vehicles (CVs) which support them. This concept allows early return to the moon while minimizing hardware development. Once in place, the Campsite can be revisited for extended periods. Configuration and operations issues are addressed, and explanations of the parametric subsystem analysis, as well as descriptions of the hardware concept and performance data, are provided. Within an assumed set of launch and mission constraints, a common vehicle stage design for both the Campsite and the CV landers was the chief design driver. Accommodation of a heat-shielded, ballistic crew transportation/return vehicle, scars for later system growth and upgrades, landing the crew in close proximity to the Campsite, and appropriate kinds of robotic systems were all secondary design drivers. Physical integration of the crew module and airlock, structural system, thermal radiators, power production and storage systems, external life support consumables, and payloads are covered. The vehicle performance data were derived using a Boeing lunar transportation sizing code to optimize vehicle stage sizes and commonality. Configuration trades were conducted and detailed sketches were produced.

  5. Solar energy grid integration systems "SEGIS"

    SciTech Connect

    None, None

    2007-10-01

    The inevitable transformation of the electrical grid to a more distributed generation configuration requires solar system capabilities well beyond simple net-metered, grid-connected approaches. Time-of-use and peak-demand rate structures will require more sophisticated systems designs that integrate energy management and/or energy storage into the system architecture. Controlling power flow into and from the utility grid will be required to ensure grid reliability and power quality. Alternative protection strategies will also be required to accommodate large numbers of distributed energy sources. This document provides an overview of the R&D needs and describes some pathways to promising solutions. The solutions will, in many cases, require R&D of new components, innovative inverter/controllers, energy management systems, innovative energy storage and a suite of advanced control algorithms, technical methodologies, protocols and the associated communications. It is expected that these solutions will help to push the “advanced integrated system” and “smart grid” evolutionary processes forward in a faster but focused manner.

  6. Tracking-integrated systems for concentrating photovoltaics

    NASA Astrophysics Data System (ADS)

    Apostoleris, Harry; Stefancich, Marco; Chiesa, Matteo

    2016-04-01

    Concentrating photovoltaic (CPV) systems, which use optical elements to focus light onto small-area solar cells, have the potential to minimize the costs, while improving efficiency, of photovoltaic technology. However, CPV is limited by the need to track the apparent motion of the Sun. This is typically accomplished using high-precision mechanical trackers that rotate the entire module to maintain normal light incidence. These machines are large, heavy and expensive to build and maintain, deterring commercial interest and excluding CPV from the residential market. To avoid this issue, some attention has recently been devoted to the development of tracking-integrated systems, in which tracking is performed inside the CPV module itself. This creates a compact system geometry that could be less expensive and more suitable for rooftop installation than existing CPV trackers. We review the basic tracking principles and concepts exploited in these systems, describe and categorize the existing designs, and discuss the potential impact of tracking integration on CPV cost models and commercial potential.

  7. The space station integrated refuse management system

    NASA Technical Reports Server (NTRS)

    Anderson, Loren A.

    1988-01-01

    The design and development of an Integrated Refuse Management System for the proposed International Space Station was performed. The primary goal was to make use of any existing potential energy or material properties that refuse may possess. The secondary goal was based on the complete removal or disposal of those products that could not, in any way, benefit astronauts' needs aboard the Space Station. The design of a continuous living and experimental habitat in space has spawned the need for a highly efficient and effective refuse management system capable of managing nearly forty-thousand pounds of refuse annually. To satisfy this need, the following four integrable systems were researched and developed: collection and transfer; recycle and reuse; advance disposal; and propulsion assist in disposal. The design of a Space Station subsystem capable of collecting and transporting refuse from its generation site to its disposal and/or recycling site was accomplished. Several methods of recycling or reusing refuse in the space environment were researched. The optimal solution was determined to be the method of pyrolysis. The objective of removing refuse from the Space Station environment, subsequent to recycling, was fulfilled with the design of a jettison vehicle. A number of jettison vehicle launch scenarios were analyzed. Selection of a proper disposal site and the development of a system to propel the vehicle to that site were completed. Reentry into the earth atmosphere for the purpose of refuse incineration was determined to be the most attractive solution.

  8. Systems integration of lunar Campsite vehicles

    NASA Astrophysics Data System (ADS)

    Capps, Stephen; Ruff, Theron

    This paper describes the configuration design and subsystems integration resolution for lunar Campsite vehicles and the crew vehicles (CVs) which support them. This concept allows early return to the moon while minimizing hardware development. Once in place, the Campsite can be revisited for extended periods. Configuration and operations issues are addressed, and explanations of the parametric subsystem analysis, as well as descriptions of the hardware concept and performance data, are provided. Within an assumed set of launch and mission constraints, a common vehicle stage design for both the Campsite and the CV landers was the chief design driver. Accommodation of a heat-shielded, ballistic crew transportation/return vehicle, scars for later system growth and upgrades, landing the crew in close proximity to the Campsite, and appropriate kinds of robotic systems were all secondary design drivers. Physical integration of the crew module and airlock, structural system, thermal radiators, power production and storage systems, external life support consumables, and payloads are covered. The vehicle performance data were derived using a Boeing lunar transportation sizing code to optimize vehicle stage sizes and commonality. Configuration trades were conducted and detailed sketches were produced.

  9. Guidance for Human-system Interfaces to Automatic Systems

    SciTech Connect

    O'Hara, J.M.; Higgins, J.; Stephen Fleger; Valerie Barnes

    2010-09-27

    Automation is ubiquitous in modern complex systems, and commercial nuclear- power plants are no exception. Automation is applied to a wide range of functions, including monitoring and detection, situation assessment, response planning, and response implementation. Automation has become a 'team player' supporting personnel in nearly all aspects of system operation. In light of its increasing use and importance in new- and future-plants, guidance is needed to conduct safety reviews of the operator's interface with automation. The objective of this research was to develop such guidance. We first characterized the important HFE aspects of automation, including six dimensions: Levels, functions, processes, modes, flexibility, and reliability. Next, we reviewed literature on the effects of all of these aspects of automation on human performance, and on the design of human-system interfaces (HSIs). Then, we used this technical basis established from the literature to identify general principles for human-automation interaction and to develop review guidelines. The guidelines consist of the following seven topics: Automation displays, interaction and control, automation modes, automation levels, adaptive automation, error tolerance and failure management, and HSI integration.

  10. Generating action descriptions from statistically integrated representations of human motions and sentences.

    PubMed

    Takano, Wataru; Kusajima, Ikuo; Nakamura, Yoshihiko

    2016-08-01

    It is desirable for robots to be able to linguistically understand human actions during human-robot interactions. Previous research has developed frameworks for encoding human full body motion into model parameters and for classifying motion into specific categories. For full understanding, the motion categories need to be connected to the natural language such that the robots can interpret human motions as linguistic expressions. This paper proposes a novel framework for integrating observation of human motion with that of natural language. This framework consists of two models; the first model statistically learns the relations between motions and their relevant words, and the second statistically learns sentence structures as word n-grams. Integration of these two models allows robots to generate sentences from human motions by searching for words relevant to the motion using the first model and then arranging these words in appropriate order using the second model. This allows making sentences that are the most likely to be generated from the motion. The proposed framework was tested on human full body motion measured by an optical motion capture system. In this, descriptive sentences were manually attached to the motions, and the validity of the system was demonstrated. PMID:27138360

  11. An integrative transcriptomic atlas of organogenesis in human embryos

    PubMed Central

    Gerrard, Dave T; Berry, Andrew A; Jennings, Rachel E; Piper Hanley, Karen; Bobola, Nicoletta; Hanley, Neil A

    2016-01-01

    Human organogenesis is when severe developmental abnormalities commonly originate. However, understanding this critical embryonic phase has relied upon inference from patient phenotypes and assumptions from in vitro stem cell models and non-human vertebrates. We report an integrated transcriptomic atlas of human organogenesis. By lineage-guided principal components analysis, we uncover novel relatedness of particular developmental genes across different organs and tissues and identified unique transcriptional codes which correctly predicted the cause of many congenital disorders. By inference, our model pinpoints co-enriched genes as new causes of developmental disorders such as cleft palate and congenital heart disease. The data revealed more than 6000 novel transcripts, over 90% of which fulfil criteria as long non-coding RNAs correlated with the protein-coding genome over megabase distances. Taken together, we have uncovered cryptic transcriptional programs used by the human embryo and established a new resource for the molecular understanding of human organogenesis and its associated disorders. DOI: http://dx.doi.org/10.7554/eLife.15657.001 PMID:27557446

  12. Integrated Assessment Systems for Chemical Warfare Material

    SciTech Connect

    A. M. Snyder; D. A. Verrill; G. L. Thinnes; K. D. Watts; R. J. McMorland

    1999-05-27

    The US Army must respond to a variety of situations involving suspect discovered, recovered, stored, and buried chemical warfare materiel (CWM). In some cases, the identity of the fill materiel and the status of the fusing and firing train cannot be visually determined due to aging of the container, or because the item is contained in an over-pack. In these cases, non-intrusive assessments are required to provide information to allow safe handling, storage, and disposal of the materiel. This paper will provide an overview of the integrated mobile and facility-based CWM assessment system prototypes that have been, and are being developed, at the Idaho National Engineering and Environmental Laboratory (INEEL) for the US Army Non-Stockpile Chemical Materiel Project. In addition, this paper will discuss advanced sensors being developed to enhance the capability of the existing and future assessment systems. The Phase I Mobile Munitions Assessment System (MMAS) is currently being used by the Army's Technical Escort Unit (TEU) at Dugway Proving Ground, Utah. This system includes equipment for non-intrusively identifying the munitions fill materiel and for assessing the condition and stability of the fuzes, firing trains, and other potential safety hazards. The system provides a self-contained, integrated command post including an on-board computer system, communications equipment, video and photographic equipment, weather monitoring equipment, and miscellaneous safety-related equipment. The Phase II MMAS is currently being tested and qualified for use by the INEEL and the US Army. The Phase II system contains several new assessment systems that significantly enhance the ability to assess CWM. A facility-based munitions assessment system prototype is being developed for the assessment of CWM stored in igloos at Pine Bluff Arsenal, Arkansas. This system is currently in the design and fabrication stages. Numerous CWM advanced sensors are being developed and tested, and

  13. Integrated Human-Robotic Missions to the Moon and Mars: Mission Operations Design Implications

    NASA Technical Reports Server (NTRS)

    Korth, David; LeBlanc, Troy; Mishkin, Andrew; Lee, Young

    2006-01-01

    For most of the history of space exploration, human and robotic programs have been independent, and have responded to distinct requirements. The NASA Vision for Space Exploration calls for the return of humans to the Moon, and the eventual human exploration of Mars; the complexity of this range of missions will require an unprecedented use of automation and robotics in support of human crews. The challenges of human Mars missions, including roundtrip communications time delays of 6 to 40 minutes, interplanetary transit times of many months, and the need to manage lifecycle costs, will require the evolution of a new mission operations paradigm far less dependent on real-time monitoring and response by an Earthbound operations team. Robotic systems and automation will augment human capability, increase human safety by providing means to perform many tasks without requiring immediate human presence, and enable the transfer of traditional mission control tasks from the ground to crews. Developing and validating the new paradigm and its associated infrastructure may place requirements on operations design for nearer-term lunar missions. The authors, representing both the human and robotic mission operations communities, assess human lunar and Mars mission challenges, and consider how human-robot operations may be integrated to enable efficient joint operations, with the eventual emergence of a unified exploration operations culture.

  14. Integrated Human-Robotic Missions to the Moon and Mars: Mission Operations Design Implications

    NASA Technical Reports Server (NTRS)

    Mishkin, Andrew; Lee, Young; Korth, David; LeBlanc, Troy

    2007-01-01

    For most of the history of space exploration, human and robotic programs have been independent, and have responded to distinct requirements. The NASA Vision for Space Exploration calls for the return of humans to the Moon, and the eventual human exploration of Mars; the complexity of this range of missions will require an unprecedented use of automation and robotics in support of human crews. The challenges of human Mars missions, including roundtrip communications time delays of 6 to 40 minutes, interplanetary transit times of many months, and the need to manage lifecycle costs, will require the evolution of a new mission operations paradigm far less dependent on real-time monitoring and response by an Earthbound operations team. Robotic systems and automation will augment human capability, increase human safety by providing means to perform many tasks without requiring immediate human presence, and enable the transfer of traditional mission control tasks from the ground to crews. Developing and validating the new paradigm and its associated infrastructure may place requirements on operations design for nearer-term lunar missions. The authors, representing both the human and robotic mission operations communities, assess human lunar and Mars mission challenges, and consider how human-robot operations may be integrated to enable efficient joint operations, with the eventual emergence of a unified exploration operations culture.

  15. SOA approach for integration of departmental systems.

    PubMed

    Itälä, Timo; Ukkola, Jari; Virtanen, Aino; Mykkänen, Juha

    2008-01-01

    In this paper a unified method for integration of departmental systems into the main systems of a healthcare organization is described. The approach is based on combining Business Process Modeling (BPM) and Service Oriented Architecture (SOA) methods and technologies. A top-down approach is used for modeling the care process and supporting care services which in turn are decomposed down to such a level of granularity that they can be described and implemented as web services described with Web Services Description Language (WSDL) documents. Then a bottom-up approach is used for wrapping the existing departmental systems and their interfaces into web services using Enterprise Service Bus (ESB). Finally the orchestration of the services is described using executable Business Process Execution Language (BPEL) code. PMID:18487817

  16. Video integrated measurement system. [Diagnostic display devices

    SciTech Connect

    Spector, B.; Eilbert, L.; Finando, S.; Fukuda, F.

    1982-06-01

    A Video Integrated Measurement (VIM) System is described which incorporates the use of various noninvasive diagnostic procedures (moire contourography, electromyography, posturometry, infrared thermography, etc.), used individually or in combination, for the evaluation of neuromusculoskeletal and other disorders and their management with biofeedback and other therapeutic procedures. The system provides for measuring individual diagnostic and therapeutic modes, or multiple modes by split screen superimposition, of real time (actual) images of the patient and idealized (ideal-normal) models on a video monitor, along with analog and digital data, graphics, color, and other transduced symbolic information. It is concluded that this system provides an innovative and efficient method by which the therapist and patient can interact in biofeedback training/learning processes and holds considerable promise for more effective measurement and treatment of a wide variety of physical and behavioral disorders.

  17. Integrated tools for control-system analysis

    NASA Technical Reports Server (NTRS)

    Ostroff, Aaron J.; Proffitt, Melissa S.; Clark, David R.

    1989-01-01

    The basic functions embedded within a user friendly software package (MATRIXx) are used to provide a high level systems approach to the analysis of linear control systems. Various control system analysis configurations are assembled automatically to minimize the amount of work by the user. Interactive decision making is incorporated via menu options and at selected points, such as in the plotting section, by inputting data. There are five evaluations such as the singular value robustness test, singular value loop transfer frequency response, Bode frequency response, steady-state covariance analysis, and closed-loop eigenvalues. Another section describes time response simulations. A time response for random white noise disturbance is available. The configurations and key equations used for each type of analysis, the restrictions that apply, the type of data required, and an example problem are described. One approach for integrating the design and analysis tools is also presented.

  18. Liquid Metal Integrated Test System (LIMITS).

    SciTech Connect

    McDonald, James Maurice; Troncosa, Kenneth P.; Bauer, Frederick J.; Nygren, Richard Einar; Youchison, Dennis Lee; Lutz, Thomas Joseph; Ulrickson, Michael Andrew; Tanaka, Tina Joan

    2003-08-01

    This paper describes the liquid metal integrated test system (LIMITS) at Sandia National Laboratories. This system was designed to study the flow of molten metals and salts in a vacuum as a preliminary study for flowing liquid surfaces inside of magnetic fusion reactors. The system consists of a heated furnace with attached centrifugal pump, a vacuum chamber, and a transfer chamber for storage and addition of fresh material. Diagnostics include an electromagnetic flow meter, a high temperature pressure transducer, and an electronic level meter. Many ports in the vacuum chamber allow testing the thermal behavior of the flowing liquids heated with an electron beam or study of the effect of a magnetic field on motion of the liquid. Some preliminary tests have been performed to determine the effect of a static magnetic field on stream flow from a nozzle.

  19. The Space Station integrated refuse management system

    NASA Technical Reports Server (NTRS)

    1988-01-01

    The University of Central Florida's design of an Integrated Refuse Management System for the proposed International Space Station is addressed. Four integratable subsystems capable of handling an estimated Orbiter shortfall of nearly 40,000 lbs of refuse produced annually are discussed. The subsystems investigated were: (1) collection and transfer; (2) recycle and reuse; (3) advanced disposal; and (4) propulsion assist in disposal. Emphasis is placed on the recycling or reuse of those materials ultimately providing a source of Space Station refuse. Special consideration is given to various disposal methods capable of completely removing refuse from close proximity of the Space Station. There is evidence that pyrolysis is the optimal solution for disposal of refuse through employment of a Rocket Jettison Vehicle. Additionally, design considerations and specifications of the Refuse Management System are discussed. Optimal and alternate design solutions for each of the four subsystems are summarized. Finally, the system configuration is described and reviewed.

  20. 46 CFR 111.105-5 - System integrity.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false System integrity. 111.105-5 Section 111.105-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Hazardous Locations § 111.105-5 System integrity. In order to maintain system integrity, each individual electrical installation in...