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  1. I-131-MIBG therapies.

    PubMed

    Vöö, Stefan; Bucerius, Jan; Mottaghy, Felix M

    2011-11-01

    Metaiodobenzylguanidine (MIBG) is a tracer that selectively targets neuroendocrine cells. On this basis, radiolabeled iodinated-MIBG (I-131-MIBG) has been introduced as a molecular nuclear therapy in the management of neuroendocrine tumors, including neuroblastoma, pheochromocytoma, paraganglioma, neuroendocrine carcinomas, and other rare neuroendocrine tumors. Extensive work has been addressed to develop I-131-MIBG therapy: doses, therapeutic schemes, and efficiency. In this paper, we present an overview on I-131-MIBG therapy, with main focus on different aspects how to perform this treatment. Copyright © 2011 Elsevier Inc. All rights reserved.

  2. Radioactive Iodine (I-131) Therapy for Hyperthyroidism

    MedlinePlus

    ... Physician Resources Professions Site Index A-Z Radioactive Iodine (I-131) Therapy Radioiodine therapy is a nuclear ... thyroid cancer. When a small dose of radioactive iodine I-131 (an isotope of iodine that emits ...

  3. Recurrent thyrotoxicosis after I-131 induced hypothyroidism

    SciTech Connect

    Liu, L.; Borowski, G.D.; Shtasel, P.; Rose, L.I.

    1984-01-01

    The first clinically and biochemically documented case of recurrent thyrotoxicosis after I-131 induced hypothyroidism in a patient with Graves' disease is reported. Two months after the administration of 9.2 mCi of I-131, the subject developed hypothyroidism. One month later, the patient became euthyroid. Then, nine months following ablation, the patient again developed thyrotoxicosis. A second dose of I-131 of 12.5 mCi was required to finally produce permanent hypothyroidism. This case illustrates the recurrence of hypothyroidism after what had seemed to have been adequate I-131 radiation.

  4. Tositumomab and Iodine I 131 Tositumomab

    Cancer.gov

    This page contains brief information about tositumomab and iodine I 131 tositumomab and a collection of links to more information about the use of this drug combination, research results, and ongoing clinical trials.

  5. I-131 MIBG imaging of carcinoid tumors

    SciTech Connect

    Blinder, R.A.; Feldman, J.M.; Coleman, R.E.

    1985-05-01

    The potential of I-131 MIBG to image carcinoid tumors was evaluated in nine patients with pathologically proven carcinoid. Three patients with foregut carcinoid tumors (2 bronchial and one pancreatic), had abnormal urinary 5-HIAA, and one had the carcinoid syndrome. Six patients had midgut carcinoid tumors (5 ileal and 1 cecal), 5 had abnormal urinary 5-HIAA, and 4 had the carcinoid syndrome. All of the patients with midgut carcinoids had metestatic disease to the liver and/or mesentery. Two hundred microcuries of I-131 MIBG were injected intravenously and the patients were studied at 24 and 48 hours. In all patients except those with bronchial carcinoids Tc-99m sulfur colloid liver exams with computer subtraction were performed during the study. The patients with bronchial carcinoids showed no uptake in the tumors. The patient with a pancreatic carcinoid who had carcinoid syndrome demonstrated tumor uptake in hepatic metastases. Of the six patients with midgut carcinoids, 4 demonstrated MIBG uptake in tumors. One patient with mesenteric disease did not have definitive tumor uptake. A second patient with liver involvement at surgery was negative on the MIBG study. Hepatic CT and scintigraphy were negative and the patient's 5-HIAA was normal. The 4 patients with carcinoid syndrome had abnormal MIBG scans. I-131 MIBG demonstrated tumor in 4 of six patients with midgut carcinoids. MIBG was not concentrated in two carcinoids of bronchial origin. The five patients with carcinoid syndrome had positive scans. MIBG has potential as a diagnostic agent in carcinoid tumors.

  6. Scintigraphic imaging of neuroblastoma with I-131-meta-iodobenzylguanidine (I-131-MIBG)

    SciTech Connect

    Feine, U.; Treuner, J.; Schauenburg, W.M.; Niethammer, D.; Meinke, J.; Elbach, E.; Dopfer, R.; Klingebiel, T.

    1984-01-01

    I-131MIBG is commonly used for the scintigraphic localization of phaeochromocytoma. The authors present data which indicate that the neuroblastoma may show a similar or even higher accumulation of I-131-MIBG. Four children were examined quantitatively by 8'' crystal dual head whole body scanner interfaced to a computer. Scans were performed 4 h, to 21 dp.i. of 1-4 MBq (25-100 ..mu..Ci) I-131-MIBG. Three of the four children aged 2 months to 2.8 years had large tumor masses in the abdomen or diffuse infiltration of the enlarged liver and high catecholamine levels in 24 h urine samples. They showed high tumor uptake of the tracer already in the 4 h scans. The uptake level correlated well with the catecholamine excretion. The biological half live was in all three cases for about 4 days. In the following days contrast between tumor and non tumor tissues became excellent. The fourth child was clinically free of tumor one year after cytostatic treatment and had normal catecholamine levels. The MIBG-scans did not show any tumor uptake but the myocardium and the salivary glands show pronounced tracer uptake according to the results of a previous study. The authors conclude that MIBG may not be only a diagnostic-tracer for neuroblastoma but may perhaps permit therapy.

  7. Scintigraphic depiction of an insulinoma by I-131 metaiodobenzylguanidine

    SciTech Connect

    Geatti, O.; Shapiro, B.; Barillari, B. )

    1989-12-01

    Scintigraphy with I-131 metaiodobenzylguanidine (MIBG) was effective in depicting a pancreatic insulinoma in a patient suffering from intermittent hypoglycemia. This observation widens the range of neuroendocrine tumors that take up to I-131 MIBG and supports the concept that many tumors of the amine precursor uptake and decarboxylation system may be imaged in this way.

  8. [Efficacy of treatment with I(131) in paediatric Graves disease].

    PubMed

    Enes Romero, P; Martín-Frías, M; de Jesús, M; Caballero Loscos, C; Alonso Blanco, M; Barrio Castellanos, R

    2014-01-01

    Radioiodine is an important therapeutic option in young patients with Grave's disease (GD). In the United States it is a widespread therapy, but in Europe its use in paediatrics is still controversial. To report our experience in radioiodine therapy of paediatric GD patients and analyse its effectiveness and safety. We retrospectively studied our paediatric population (<18 years of age) with GD, diagnosed from 1982 to 2012. A curative option was offered to patients who did not respond to anti-thyroid drug (AT) at puberty. We analysed, the patient characteristics, TSH, T4, T3 and thyroid antibodies levels, AT response, remission post I(131), side effects, and hypothyroidism rates. A total of 50 patients were diagnosed with GD from 1982 to 2012. All patients received AT as initial treatment (mean duration: 35.3±25.9 months). Permanent remission was achieved in 46%. Thyroidectomy was performed in 5 patients, and 14 patients received I(131) (mean dose: 10.9±1.09 mCi). Remission with I(131) was obtained in 100%. The rate of permanent hypothyroidism was 90%. There was no progression of ophthalmopathy or side effects in any patients treated with I(131.) Radioiodine treatment of paediatric GD patients is safe, leads to complete remission at the expense of hypothyroidism, and does not exacerbate ophthalmopathy. It can be considered in patients older than 5 years, who do no not respond to AT or with significant side effects with this medication. Copyright © 2012 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.

  9. Scintigraphy of a neuroblastoma with I-131 meta-iodobenzylguanidine

    SciTech Connect

    Kimmig, B.; Brandeis, W.E.; Eisenhut, M.; Bubeck, B.; Hermann, H.J.; zum Winkel, K.

    1984-07-01

    Radioiodinated m-iodobenzylguanidine has been applied mainly for the diagnosis of pheochromocytoma and blastoma. In this paper the author shows that an ontogenetically related tumor, the neuroblastoma, is also scintigraphically visualized by its high uptake of I-131 MIBG. Because of the kinetic findings and the high uptake of more than 30% of the injected activity, it is likely that the neuroblastoma, by analogy with pheochromocytoma, is susceptible to specific radionuclide therapy.

  10. Scintigraphy of a neuroblastoma with I-131 meta-iodobenzylguanidine

    SciTech Connect

    Kimmig, B.; Brandeis, W.E.; Eisenhut, M.; Bubeck, B.; Hermann, H.J.; Zum Winkel, K.

    1984-07-01

    Radioiodinated m-iodobenzylguanidine has been applied mainly for the diagnosis of pheochromocytoma and blastoma. In this paper the authors show that an ontogenetically related tumor, the neuroblastoma, is also scintigraphically visualized by its high uptake of I-131 MIBG. Because of the kinetic findings and the high uptake of more than 30% of the injected activity, it is likely that the neuroblastoma, by analogy with pheochromocytoma, is susceptible to specific radionuclide therapy.

  11. Microwave assistance of labeling hippuric acid by I-131.

    PubMed

    Sherlock Huang, Lin-Chiang; Wu, Kou-Hung; Ko, Pi-Wen; Hsieh, Cheng-Ying; Pao, Kuan-Chuan; Chou, Shih-Ching; Shieh, Fa-Kuen; Sureshbabu, Radhakrishnan; Hsu, Ming-Hua

    2014-07-01

    This work presents a novel approach for labeling hippuric acid with I-131 using microwaves. It utilizes copper(II) acetate as a catalyst of the labeling. The process involves the use of this catalytic copper(II) acetate at low dilutions that were nevertheless sufficient to produce labeled hippuric acid with high radiochemical purity in a short time. Therefore, the novel technique overcomes the limitations of previously reported conventional methods that involve heating. Copyright © 2014 Elsevier Ltd. All rights reserved.

  12. The Purity of Radioiodide-I131 Assessed by in Vivo and in Vitro Methods

    PubMed Central

    Fawcett, D. M.; Olde, G. L.; McLeod, L. E.

    1962-01-01

    Between 41 and 94% of the radioactivity of 24 preparations of I131 supplied without cysteine preservative was non-iodide on chromatographic analysis. Extraneous radio-activity was essentially absent from I131 supplied with cysteine. It was converted to iodide-I131 by 10-3 M cysteine or iodide but not by incubation at pH 2. The average thyroid uptake of I131 containing extraneous radioactivity was significantly lower than the uptake of I131 free from non-iodide impurity in 16 human subjects measured under controlled conditions and in a random group of 669 patients. Incubation of samples of I131 containing non-iodide radioactivity with tyrosine and cupric chloride resulted in the non-enzymatic formation of monoiodotyrosine-I131 either in the presence or absence of thyroid homogenate. Enzymatic formation of monoiodotyrosine-I131 by thyroid homogenates could be demonstrated only when I131 free from extraneous activity was used. ImagesFig. 1Fig. 2 PMID:13891874

  13. The detection of thrombosis using I-131 labeled thrombospondin

    SciTech Connect

    Perlman, S.B.; Folts, J.D.; Hammes, R.J.; Besozzi, M.C.; Mosher, D.F.

    1985-05-01

    There are methods available for detecting intravascular thrombosis (IVT) but none are noninvasive, rapid and accurate. Iodine-131 labeled thrombospondin (I-TSP) is being evaluated as a method of detecting IVT. Thrombospondin is obtained from human platelet concentrate and labeled with I-131 using the chloramine-T technique. Anesthetized dogs are known to develop thrombi in stenosed arteries and veins with or without moderate initial damage. IVT is detected by blood flow declines as measured with an electromagnetic flow meter (EMF) probe on the vessel being studied. Undamaged comparable vessels were used as controls. After IVT is initiated, I-TSP is given IV. Vessels with thrombi are harvested at various times, weighed and counted in a gamma counter to determine if the thrombi accumulated labeled I-TSP. Vessels with thrombi harvested at 30, 45 or 60 minutes after injection of I-TSP did not accumulate I-TSP whereas vessels obtained at 90 and 150 minutes after injection did accumulate I-TSP when compared to their control vessels or whole blood. The ratios of I-TSP in the stenosed vessels with thrombi, compared to whole blood or the control undamaged vessels ranged from 2.33/1 to 6.92/1. The ratio of counts for vessels with intimal damage alone ranged from 0.88/1 to 1.05/1 while the ratio of counts from control vessels was 0.98/1 to 1.09/1.

  14. Impact of reconstruction parameters on quantitative I-131 SPECT

    NASA Astrophysics Data System (ADS)

    van Gils, C. A. J.; Beijst, C.; van Rooij, R.; de Jong, H. W. A. M.

    2016-07-01

    Radioiodine therapy using I-131 is widely used for treatment of thyroid disease or neuroendocrine tumors. Monitoring treatment by accurate dosimetry requires quantitative imaging. The high energy photons however render quantitative SPECT reconstruction challenging, potentially requiring accurate correction for scatter and collimator effects. The goal of this work is to assess the effectiveness of various correction methods on these effects using phantom studies. A SPECT/CT acquisition of the NEMA IEC body phantom was performed. Images were reconstructed using the following parameters: (1) without scatter correction, (2) with triple energy window (TEW) scatter correction and (3) with Monte Carlo-based scatter correction. For modelling the collimator-detector response (CDR), both (a) geometric Gaussian CDRs as well as (b) Monte Carlo simulated CDRs were compared. Quantitative accuracy, contrast to noise ratios and recovery coefficients were calculated, as well as the background variability and the residual count error in the lung insert. The Monte Carlo scatter corrected reconstruction method was shown to be intrinsically quantitative, requiring no experimentally acquired calibration factor. It resulted in a more accurate quantification of the background compartment activity density compared with TEW or no scatter correction. The quantification error relative to a dose calibrator derived measurement was found to be  <1%,-26% and 33%, respectively. The adverse effects of partial volume were significantly smaller with the Monte Carlo simulated CDR correction compared with geometric Gaussian or no CDR modelling. Scatter correction showed a small effect on quantification of small volumes. When using a weighting factor, TEW correction was comparable to Monte Carlo reconstruction in all measured parameters, although this approach is clinically impractical since this factor may be patient dependent. Monte Carlo based scatter correction including accurately simulated CDR

  15. Impact of reconstruction parameters on quantitative I-131 SPECT.

    PubMed

    van Gils, C A J; Beijst, C; van Rooij, R; de Jong, H W A M

    2016-07-21

    Radioiodine therapy using I-131 is widely used for treatment of thyroid disease or neuroendocrine tumors. Monitoring treatment by accurate dosimetry requires quantitative imaging. The high energy photons however render quantitative SPECT reconstruction challenging, potentially requiring accurate correction for scatter and collimator effects. The goal of this work is to assess the effectiveness of various correction methods on these effects using phantom studies. A SPECT/CT acquisition of the NEMA IEC body phantom was performed. Images were reconstructed using the following parameters: (1) without scatter correction, (2) with triple energy window (TEW) scatter correction and (3) with Monte Carlo-based scatter correction. For modelling the collimator-detector response (CDR), both (a) geometric Gaussian CDRs as well as (b) Monte Carlo simulated CDRs were compared. Quantitative accuracy, contrast to noise ratios and recovery coefficients were calculated, as well as the background variability and the residual count error in the lung insert. The Monte Carlo scatter corrected reconstruction method was shown to be intrinsically quantitative, requiring no experimentally acquired calibration factor. It resulted in a more accurate quantification of the background compartment activity density compared with TEW or no scatter correction. The quantification error relative to a dose calibrator derived measurement was found to be  <1%,-26% and 33%, respectively. The adverse effects of partial volume were significantly smaller with the Monte Carlo simulated CDR correction compared with geometric Gaussian or no CDR modelling. Scatter correction showed a small effect on quantification of small volumes. When using a weighting factor, TEW correction was comparable to Monte Carlo reconstruction in all measured parameters, although this approach is clinically impractical since this factor may be patient dependent. Monte Carlo based scatter correction including accurately simulated CDR

  16. 76 FR 81517 - Agency Information Collection Activities: Form I-131, Revision of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-28

    ... the Form/Collection: Application for Travel Document. (3) Agency form number, if any, and the... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-131... Collection Under Review: Form I- 131, Application for Travel Document. The Department of Homeland Security,...

  17. 77 FR 15787 - Agency Information Collection Activities: Form I-131, Revision of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-16

    ... the Form/Collection: Application for Travel Document. (3) Agency Form Number, if any, and the... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-131... Collection Under Review: Form I- 131, Application for Travel Document. The Department of Homeland Security,...

  18. Pregnancy Outcome After I-131 Therapy for Patients With Thyroid Cancer

    PubMed Central

    Ko, Kuan-Yin; Yen, Ruoh-Fang; Lin, Cheng-Li; Cheng, Mei-Fang; Huang, Wen-Sheng; Kao, Chia-Hung

    2016-01-01

    Abstract The aim of this study was to evaluate the influence of I-131 therapy on pregnancy outcome in patients that received therapeutic I-131 doses for thyroid cancer in Taiwan. This nationwide population-based cohort study was based on data from 1998 to 2010 obtained from the Taiwanese National Health Insurance Research Database. We identified 11,708 women with thyroid cancer (≥15 and ≤50 years of age) by International Classification of Diseases, Ninth Revision, Clinical Modification codes. Patients were divided into 2 cohorts: I-131 therapy cohort and non-I-131 therapy cohort. The mean follow-up period was 6.08 years for the I-131 cohort and 6.87 years for the non-I-131 cohort. The case cohort and the control cohort comprised 775 and 716 pregnant patients, respectively. The overall incidence of pregnancy was significantly lower in the I-131 cohort (adjusted HR = 0.77, 95% CI = 0.70–0.86) and it was also observed when the patients were stratified according to age (HR = 0.73, 95% CI = 0.64–0.83 in 25–34 years; HR = 0.63, 95% CI = 0.49–0.82 in 35–44 years). Patients in the I-131 cohort had a lower successful delivery rate, particularly among patients in 25 to 34 years (OR = 0.60, 95% CI = 0.45–0.80). No significant difference was observed for adverse pregnancy conditions between 2 cohorts. I-131 therapy is associated with decreased pregnancy and successful delivery rates. The underlying mechanism likely involves physician recommendation, patient's psychological issue, and potential impact of I-131 treatment on reproductive health. Further investigation is needed. PMID:26844507

  19. Clinical comparison of I-131 orthoiodohippurate and the kit formulation of Tc-99m mercaptoacetyltriglycine

    SciTech Connect

    Taylor, A. Jr.; Ziffer, J.A.; Steves, A.; Eshima, D.; Delaney, V.B.; Welchel, J.D.

    1989-03-01

    Previous studies in animals and humans have shown that technetium-99m mercaptoacetyltriglycine (MAG3) purified by high-performance liquid chromatography is a renal tubular agent with characteristics similar to those of iodine-131 orthoiodohippurate (OIH). A kit formulation for Tc-99m MAG3 has been developed and compared with I-131 OIH in 17 patients with suspected renal dysfunction and three potential kidney donors. There were no adverse reactions. Tc-99m MAG3 images were of good quality and consistently better than I-131 OIH images. There was no significant difference in the relative renal uptake of Tc-99m MAG3 and I-131 OIH. The 30-minute urinary excretion of Tc-99m MAG3 was 36.4%, versus 40.4% for I-131 OIH. The average plasma clearance of Tc-99m MAG3 (138 mL/min +/- 117) was less than that of I-131 OIH (272 mL/min +/- 205) (P less than .001); however, there was good correlation between the Tc-99m MAG3 and I-131 OIH clearances (r = .87). The volume of distribution of Tc-99m MAG3 (5.96 L +/- 1.94) was less than that of I-131 OIH (9.41 L +/- 3.73) (P less than .001). These characteristics and the advantages of a simple kit formulation should lead to widespread clinical use.

  20. Normal and abnormal distribution of the adrenomedullary imaging agent m-(I-131)iodobenzylguanidine (I-131 MIBG) in man; evaluation by scintigraphy

    SciTech Connect

    Nakajo, M.; Shapiro, B.; Copp, J.; Kalff, V.; Gross, M.D.; Sisson, J.C.; Beierwaltes, W.H.

    1983-08-01

    The scintigraphic distribution of m-(/sup 131/I)iodobenzylguanidine (I-131 MIBG), an adrenal medullary imaging agent, was studied to determine the patterns of uptake of this agent in man. The normal distribution of I-131 MIBG includes clear portrayal of the salivary glands, liver, spleen, and urinary bladder. The heart, middle and lower lung zones, and colon were less frequently or less clearly seen. The upper lung zones and kidneys were seldom visualized. The thyroid appeared only in cases of inadequate thyroidal blockade. The normal adrenal glands were seldom seen and faintly imaged in 2% at 24 h after injection and in 16% at 48 h, in patients shown not to have pheochromocytomas, whereas intra-adrenal, extra-adrenal, and malignant pheochromocytomas usually appeared as intense focal areas of I-131 MIBG uptake at 24 through 72 h.

  1. Cystic thyroid mass following I-131 treatment of papillary thyroid carcinoma: An unusual complication

    SciTech Connect

    Morrish, D.W.; Jackson, F.I.; Lalani, Z.H.; Catz, Z.; Sloboda, R. )

    1989-12-01

    Several unusual complications of I-131 therapy for thyroid carcinoma are known. Two patients who developed a further unusual event that consisted of a palpable mass and cystic degeneration are described.

  2. Late presentation of metastatic pheochromocytoma: A problem case solved by I-131 MIBG scintigraphy

    SciTech Connect

    Geatti, O.; Shapiro, B.; Virgolini, L. )

    1990-02-01

    A patient presented with recurrent pheochromocytoma 10 years following the apparently successful surgical cure of a right adrenal pheochromocytoma. Conventional medical imaging techniques, (chest radiograph, abdominal ultrasound, and abdominal CT) suggested local recurrence for which surgery was planned. I-131 MIBG scintigraphy revealed disseminated metastatic disease that rendered attempts at surgical cure futile. The patient was treated with three therapeutic doses of I-131 MIBG with good symptomatic palliation and improvement of some biochemical parameters.

  3. Role of gambogic acid and NaI131 in A549/DDP cells

    PubMed Central

    Huang, Jing; Zhu, Xiaoli; Wang, Huan; Han, Shuhua; Liu, Lu; Xie, Yan; Chen, Daozhen; Zhang, Qiang; Zhang, Li; Hu, Yue

    2017-01-01

    Resistance to platinum in tumor tissue is a considerable barrier against effective lung cancer treatment. Radionuclide therapy is the primary adjuvant treatment, however, the toxic side effects limit its dosage in the clinical setting. Therefore, the present study aimed to determine whether an NaI131 radiosensitizer could help reduce the toxic side effects of radionuclide therapy. In vitro experiments were conducted to determine whether NaI131 can inhibit platinum resistance in A549/DDP cells, which are cisplatin-resistant non-small cell lung cancer cells, and whether gambogic acid (GA) is an effective NaI131 radiosensitizer. Cell proliferation following drug intervention was analyzed using MTT and isobolographic analysis. Apoptosis was assessed by flow cytometry. In addition, the mechanisms of drug intervention were analyzed by measuring the expression of P-glycoprotein (P-gP), B cell lymphoma 2 (Bcl-2), Bcl2-associated X protein (Bax) and P53 using western blot analysis and immunocytochemistry. According to isobolographic analysis, a low concentration of NaI131 combined with GA had a synergistic effect on the inhibition of A549/DDP cell proliferation, which was consistent with an increased rate of apoptosis. Furthermore, the overexpression of Bax, and the downregulation of P-gP, P53 and Bcl-2 observed demonstrated the potential mechanism(s) of NaI131 and GA intervention. NaI131 may induce apoptosis in A549/DDP cells by regulating apoptosis-related proteins. A low concentration combination of NaI131 and GA was able to significantly inhibit A549/DDP cell proliferation and induce cell apoptosis. Thus, the two drugs appear to have a synergistic effect on apoptosis of A549/DDP cells. PMID:28123519

  4. Monte Carlo simulation of the RBE of I-131 radiation using DNA damage as biomarker.

    PubMed

    Ezzati, Ahad Ollah; Mahmoud-Pashazadeh, Ali; Studenski, Matthew T

    2017-04-10

    In general, a weighting factor of one is applied for low linear energy transfer radiations. However, several studies indicate that relative biological effectiveness (RBE) of low energy photons and electrons is greater than one. The aim of this current study was calculating the RBE of I-131 radiation relative to Co-60 gamma photons in 100 μm spheroid cells using Monte Carlo (MC) simulations. These calculations were compared to experimentally measured results. MCNPX2.6 was used to simulate the I-131 and Co-60 irradiation setups and calculate the secondary electron spectra at energies higher than 1 keV with varying oxygen concentrations. The electron spectra at energies lower than 1 keV were obtained by extrapolation (down to 10 eV). The calculated electron spectra were input into the MCDS micro-dosimetric Monte Carlo code to calculate the DSB induction and related RBE. The calculated RBE of I-131 radiation relative to Co-60 photons, as the reference radiation recommended by the International Commission on Radiation Protection (ICRP), was 1.06, 1.03 and 1.02 for oxygen concentrations of 0, 5 and 100%, respectively. Results of MC simulations indicate the RBE of I-131 is greater than one. This finding, despite a 10% discrepancy with the findings of the previous in vitro study of one of the authors of this paper, reemphasizes that I-131 radiation induces more severe biological damage than current ICRP recommendations.

  5. Is thyroid scintigraphy necessary before I-131 therapy for hyperthyroidism. Concise Communication

    SciTech Connect

    Ripley, S.D.; Freitas, J.E.; Nagle, C.E.

    1984-06-01

    To assess the value of routine thyroid scintigraphy in the differential diagnosis of hyperthyroidism and as a guide to I-131 therapy, the authors prospectively examined 100 consecutive hyperthyroid patients referred for a 24-hr radioiodine uptake and I-131 therapy. The nuclear medicine physician recorded his preimaging diagnostic impression and therapeutic plan for each patient. After the (/sup 99m/Tc) pertechnetate image, the patient was reassessed to determine whether the image induced any change in the diagnosis or therapeutic plan. Seventy-nine of 80 patients with diffuse goiter to palpation, had scintigrams demonstrating no discrete focal defects and were diagnosed as Graves' disease; thus the scintigram did not contribute useful information. In 17 of 20 patients with uninodular or multinodular goiters, the image was necessary to clarify the final diagnosis and therapeutic plan. Thus, selective use of thyroid scintigraphy should decrease the number of scintigrams performed before I-131 therapy for hyperthyroidism, without compromising diagnostic accuracy or therapeutic success.

  6. False positive I-131 MIBG due to dilated renal pelvis: a case report

    SciTech Connect

    Bahar, R.H.; Mahmoud, S.; Ibrahim, A.; al-Gazzar, A.H.

    1988-12-01

    A case of false positive I-131 MIBG imaging for detection of pheochromocytoma is presented. There was an area of increased tracer uptake in the left renal region that showed steadily reducing activity over a period of three days. This raised the suspicion of a dilated renal pelvis, which was later confirmed by Tc-99m DTPA imaging. It is advisable in cases of ambiguous I-131 MIBG imaging to use Tc-99m DTPA rather than Tc-99m DMSA for localizing the kidneys and renal pelvis.

  7. Pheochromocytoma in the organ of Zukerkandl: I-131 MIBG scintigraphic localization

    SciTech Connect

    el-Desouki, M.; al-Nuaim, A.; Mofti, A.; Shanna, A.

    1989-06-01

    Scintigraphic localization of an extra-adrenal pheochromocytoma in a 27 year-old female with clinical and biochemical evidence of the disease is presented. While both ultrasonography and computed tomography were negative, I-131 MIBG scintigraphy successfully localized the extra-adrenal lesion in the organ of Zukerkandl.

  8. Effects of Dosimetrically Guided I-131 Therapy on Hematopoiesis in Patients With Differentiated Thyroid Cancer

    PubMed Central

    Bikas, Athanasios; Schneider, Mark; Desale, Sameer; Atkins, Frank; Mete, Mihriye; Burman, Kenneth D.; Wartofsky, Leonard

    2016-01-01

    Objective: The objective of the study was to evaluate the effects of dosimetrically guided I-131 prescribed activities on hematopoiesis reflected by changes in complete blood counts (CBCs). Design: This was a retrospective analysis. Setting: The study was conducted at an academic center. Patients: A total of 152 patients with differentiated thyroid cancer who had 185 dosimetrically guided I-131 treatments. Interventions: There were no interventions. Main Outcome Measures: Repeated-measure ANOVA was used for the analysis of the differences in the averages of CBCs that were documented at baseline and 1, 6, 12, 24–36, and 48–60 months after I-131 treatment. Results: All parameters decreased to their respective nadir at 1 month and then gradually returned toward baseline values. White blood cells (WBCs) and platelets (PLTs) were the most significantly affected cells. At 1 month, the decrease was 29.6% (P < .0001) for WBCs and 25% (P < .0001) for PLTs, whereas at 12 months, the decrease was 15.5% (P < .0001) and 13% (P < .0001), respectively. Lymphocytes appeared to be more susceptible to I-131 than neutrophils (ANCs). The decreases were small in absolute numbers for red blood cells, hematocrit and hemoglobin not surpassing 10%. Multivariate analysis demonstrated that the ratio of administered prescribed activity-to-maximum tolerated activity was associated with the decreases in WBCs (P = .0038), ANCs (P = .0063), and red blood cells (P = .029), with borderline significance for PLTs (P = .057) and hemoglobin (P = .057). Conclusions: Dosimetrically guided I-131 resulted in statistically significant decreases in CBC parameters, which were more prominent in WBCs and PLTs. Lymphocytes were more severely affected than ANCs, whereas all parameters reached a nadir at 1 month and then gradually returned toward baseline values over the 5-year follow-up of our study. PMID:26900639

  9. Rapid thyroidal iodine turnover in hyperthyroid patients: Incidence and impact on outcome of I-131 therapy (Rx)

    SciTech Connect

    Aktay, R.; Rezai, K.; Kirchner, P.T.

    1995-05-01

    It has been suggested that rapid thyroidal iodine turnover (RTIT) may be frequent in hyperthyroid patients and that it could cause not only I-131 therapy failures but also high radiation doses to the blood from circulating protein bound I-131 (JNM 73;14:379A). We investigated the incidence and importance of this phenomenon by comparing 4 hr to 24 hr uptake ratios with the success of I-131 therapy (3.7-5.5 MBq/gm of thyroid). Of 525 hyperthyroid patients treated at our institution between 1980 and 1993, 460 had both 4 and 24 hr uptake measurements: 370 were female, 90 male, mean age 42 years. Clinical diagnosis was Graves` disease in 402, non-Graves` disease in 58. Of the 460, 27 patients were lost to follow-up after the first I-131 Rx, 6 after the second Rx. Defining rapid turnover as early uptake {ge} late uptake, we found 71 of 460 hyperthyroids (15%) to have rapid thyroidal I-131 turnover with all but 2 in patients with Graves` disease. Of 22 patients with RTIT who failed 1st I-131 Rx, 18 (82%) were successfully treated with 2nd I-131 Rx; and of 29 with nonrapid turnover, 27 (93%) had a successful 2nd I-131 Rx. 17 of 24 (71%) patients were converted to nonrapid after the 1st I-131 Rx. The results (a) confirm a relatively high incidence of rapid thyroidal iodine turnover in hyperthyroid patients, (b) reveal a near 50% failure rate for first I-131 Rx in such patients vs. 11% for non-RTIT, (c) demonstrate a reversion to non-RTIT for most RTIT patients after first I-131 Rx, (d) show the 4 to 24 hour uptake ratios to be a guide for treatment outcome.

  10. The therapeutic efficacy of I131-PSCA-mAb in orthotopic mouse models of prostate cancer

    PubMed Central

    2013-01-01

    Background Prostate stem cell antigen (PSCA) is upregulated in prostate cancer tissues. Here we aimed to study the therapeutic efficacy of a monoclonal antibody of PSCA-labeled I131 (I131-PSCA-mAb) in orthotopic mouse models of prostate cancer. Methods The proliferation, apoptosis and invasion abilities of PC-3 and LNCaP cells treated with I131-PSCA-mAb were measured by methyl thiazolyl tetrazolium assay, flow cytometry and transwell culture, respectively. The human prostate cancer models were established by orthotopic implantation of PC-3 and LNCaP cells in nude mice. I131-PSCA-mAb distribution and tumor cell apoptosis in the tumor-bearing nude mice were measured. Results The inhibitory and apoptosis rates of PC-3 and LNCaP cells treated with I131-PSCA-mAb reached a maximum of 84%, 80% and 50%, 46%, respectively, which were obviously higher than in the cells treated with I131-IgG or PSCA-mAb. The invaded number of PC-3 and LNCaP cells treated with I131-PSCA-mAbe was significantly reduced (P < 0.01) compared with the control group. The ratios of I131-PSCA-mAb in tumor to intramuscular I131-PSCA-mAb (T/NT) in tumor-bearing nude mice were increased with time and reached the highest level after 8 h. T/NT stayed above 3.0 after 12 h, and the tumor could still be developed after 24 h. The number of apoptotic cells in tumor tissue of nude mice treated with I131-PSCA-mAb was larger than that in the control group. Conclusion I131-PSCA-mAb has the potential to become a new targeted therapy drug for the treatment of prostate cancer. PMID:24330823

  11. Development of gamma-photon/Cerenkov-light hybrid system for simultaneous imaging of I-131 radionuclide

    NASA Astrophysics Data System (ADS)

    Yamamoto, Seiichi; Suzuki, Mayumi; Kato, Katsuhiko; Watabe, Tadashi; Ikeda, Hayato; Kanai, Yasukazu; Ogata, Yoshimune; Hatazawa, Jun

    2016-09-01

    Although iodine 131 (I-131) is used for radionuclide therapy, high resolution images are difficult to obtain with conventional gamma cameras because of the high energy of I-131 gamma photons (364 keV). Cerenkov-light imaging is a possible method for beta emitting radionuclides, and I-131 (606 MeV maximum beta energy) is a candidate to obtain high resolution images. We developed a high energy gamma camera system for I-131 radionuclide and combined it with a Cerenkov-light imaging system to form a gamma-photon/Cerenkov-light hybrid imaging system to compare the simultaneously measured images of these two modalities. The high energy gamma imaging detector used 0.85-mm×0.85-mm×10-mm thick GAGG scintillator pixels arranged in a 44×44 matrix with a 0.1-mm thick reflector and optical coupled to a Hamamatsu 2 in. square position sensitive photomultiplier tube (PSPMT: H12700 MOD). The gamma imaging detector was encased in a 2 cm thick tungsten shield, and a pinhole collimator was mounted on its top to form a gamma camera system. The Cerenkov-light imaging system was made of a high sensitivity cooled CCD camera. The Cerenkov-light imaging system was combined with the gamma camera using optical mirrors to image the same area of the subject. With this configuration, we simultaneously imaged the gamma photons and the Cerenkov-light from I-131 in the subjects. The spatial resolution and sensitivity of the gamma camera system for I-131 were respectively 3 mm FWHM and 10 cps/MBq for the high sensitivity collimator at 10 cm from the collimator surface. The spatial resolution of the Cerenkov-light imaging system was 0.64 mm FWHM at 10 cm from the system surface. Thyroid phantom and rat images were successfully obtained with the developed gamma-photon/Cerenkov-light hybrid imaging system, allowing direct comparison of these two modalities. Our developed gamma-photon/Cerenkov-light hybrid imaging system will be useful to evaluate the advantages and disadvantages of these two

  12. Is it safe to treat hyperthyroid patients with I-131 without fear of thyroid storm?

    PubMed

    Vijayakumar, Vani; Nusynowwitz, M L; Ali, S

    2006-07-01

    Thyroid storm is extremely rare. However, hyperthyroid patients with severe thyrotoxicosis are frequently not treated immediately with I-131 for fear of thyroid storm but are placed on thiouracil drugs for varying periods of time. We demonstrate herein that it is safe to treat these patients with 1-131, without pretreatment with thiouracil drugs, provided they do not have complicating intercurrent disease. Our definition of severe hyperthyroidism includes marked signs and symptoms of thyrotoxicosis, suppressed TSH, markedly elevated free T4 and/or free T3 and elevated radioactive iodine uptake (RAIU) (>30%) at 4 or 24 hours. Our diagnostic criteria for thyroid storm include two or more findings of fever (>38 degrees C, 100 degrees F), severe tachycardia, high pulse pressure, agitation with tremors, flushing, sweating, heart failure, nausea, vomiting, diarrhea, jaundice associated with high free T4 and/or free T3. Patients were selected retrospectively for the period between August 2003 and December 2004. One hundred and twenty-two patient visits were identified. These patients were treated with 370-740 MBq (10-20 mCi) of I-131 and were evaluated for any evidence of thyroid storm. Most of the patients were placed on beta blocker drugs at the time of initial I-131 therapy; these were continued for at least two months, when the first follow-up visit occurred. At the time of I-131 therapy, it is our policy to educate the patients to seek immediate medical attention for exacerbation of symptoms of thyrotoxicosis. Not one of these patients developed thyroid storm. A subset of 25% of these cases with higher potential for thyroid storm (RAIU more than 65%, very marked signs and symptoms, and very markedly elevated free T4 and/or free T3) also tolerated the I-131 therapy well with marked clinical improvement and no exacerbation of the thyrotoxic state. It is safe to administer I-131 to patients who are severely hyperthyroid without fear of thyroid storm, provided beta

  13. Comparison of image quality of different iodine isotopes (I-123, I-124, and I-131).

    PubMed

    Rault, Erwann; Vandenberghe, Stefaan; Van Holen, Roel; De Beenhouwer, Jan; Staelens, Steven; Lemahieu, Ignace

    2007-06-01

    I-131 is a frequently used isotope for radionuclide therapy. This technique for cancer treatment requires a pre-therapeutic dosimetric study. The latter is usually performed (for this radionuclide) by directly imaging the uptake of the therapeutic radionuclide in the body or by replacing it by one of its isotopes, which are more suitable for imaging. This study aimed to compare the image quality that can be achieved by three iodine isotopes: I-131 and I-123 for single-photon emission computed tomography imaging, and I-124 for positron emission tomography imaging. The imaging characteristics of each isotope were investigated by simulated data. Their spectrums, point-spread functions, and contrast-recovery curves were drawn and compared. I-131 was imaged with a high-energy all-purpose (HEAP) collimator, whereas two collimators were compared for I-123: low-energy high-resolution (LEHR) and medium energy (ME). No mechanical collimation was used for I-124. The influence of small high-energy peaks (>0.1%) on the main energy window contamination were evaluated. Furthermore, the effect of a scattering medium was investigated and the triple energy window (TEW) correction was used for spectral-based scatter correction. Results showed that I-123 gave the best results with a LEHR collimator when the scatter correction was applied. Without correction, the ME collimator reduced the effects of high-energy contamination. I-131 offered the worst results. This can be explained by the large amount of septal penetration from the photopeak and by the collimator, which gave a low spatial resolution. I-124 gave the best imaging properties owing to its electronic collimation (high sensitivity) and a short coincidence time window.

  14. Loss of immunoreactivity of I-131 labeled monoclonal antibody with storage is related to radiation damage

    SciTech Connect

    Reynolds, J.; Fejka, R.; Rotman, M.; Farkas, R.; Larson, S.

    1985-05-01

    In order to use a single preparation of I-131 monoclonal antibody on more than one day, it is important to determine the shelf life of these compounds. Fifteen I-131 (.128 to 15 mCi/ml) preparations of IgG or Fab fragments of antimelanoma antibody (96.5 or 48.7) were stored at 0-4/sup 0/C in pharmaceutical vials. Daily aliquots were tested for total immunoreactivity (IR) (JNM 24:123,1983), TCA precipitability and fractions using size exclusion HPLC. Loss of IR ranges from 0-54% during the first 24 hours to 0-92% over 6 days. Loss of IR occurred with both Fab and IgG. The rate of loss of IR correlated with the initial specific concentration (r = .8,p < .01) and specific activity (r = .78,p < .01) but dilution of the concentrated solution by 1000x or more stopped the deterioration process (p < .01) suggesting specific concentration to be the important variable. When mM cysteamine or cystamine were added to the concentrated solutions the loss of IR with time was inhibited (X/sup 2/,p < .001). TCA precipitation and HPLC analysis showed loss of antibody associated radioactivity but not to the extent of the change in IR. There can be significant loss of IR of I-131 monoclonal antibody during storage at 0-4/sup 0/C. and high concentration solutions (>5 mCi/ml.) must be used within 24 hours of labeling to assure an active preparation. The inhibition of IR loss by dilution or by addition of radioprotectors suggests that the process is due to radiation effects on the antibody.

  15. I-131 Dose Response for Incident Thyroid Cancers in Ukraine Related to the Chornobyl Accident

    PubMed Central

    Tronko, Mykola D.; Hatch, Maureen; Bogdanova, Tetyana I.; Oliynik, Valery A.; Lubin, Jay H.; Zablotska, Lydia B.; Tereschenko, Valery P.; McConnell, Robert J.; Zamotaeva, Galina A.; O’Kane, Patrick; Bouville, Andre C.; Chaykovskaya, Ludmila V.; Greenebaum, Ellen; Paster, Ihor P.; Shpak, Victor M.; Ron, Elaine

    2011-01-01

    Background: Current knowledge about Chornobyl-related thyroid cancer risks comes from ecological studies based on grouped doses, case–control studies, and studies of prevalent cancers. Objective: To address this limitation, we evaluated the dose–response relationship for incident thyroid cancers using measurement-based individual iodine-131 (I-131) thyroid dose estimates in a prospective analytic cohort study. Methods: The cohort consists of individuals < 18 years of age on 26 April 1986 who resided in three contaminated oblasts (states) of Ukraine and underwent up to four thyroid screening examinations between 1998 and 2007 (n = 12,514). Thyroid doses of I-131 were estimated based on individual radioactivity measurements taken within 2 months after the accident, environmental transport models, and interview data. Excess radiation risks were estimated using Poisson regression models. Results: Sixty-five incident thyroid cancers were diagnosed during the second through fourth screenings and 73,004 person-years (PY) of observation. The dose–response relationship was consistent with linearity on relative and absolute scales, although the excess relative risk (ERR) model described data better than did the excess absolute risk (EAR) model. The ERR per gray was 1.91 [95% confidence interval (CI), 0.43–6.34], and the EAR per 104 PY/Gy was 2.21 (95% CI, 0.04–5.78). The ERR per gray varied significantly by oblast of residence but not by time since exposure, use of iodine prophylaxis, iodine status, sex, age, or tumor size. Conclusions: I-131–related thyroid cancer risks persisted for two decades after exposure, with no evidence of decrease during the observation period. The radiation risks, although smaller, are compatible with those of retrospective and ecological post-Chornobyl studies. PMID:21406336

  16. Treatment of metastatic para-aortic paraganglioma by surgery, radiotherapy and I-131 mIBG.

    PubMed

    Ball, A B; Tait, D M; Fisher, C; Sinnett, H D; Harmer, C L

    1991-10-01

    A patient with a malignant, functioning, aortico-sympathetic paraganglioma and a solitary bone metastasis causing paraplegia was treated by spinal decompression, irradiation of the metastasis, surgical excision of the primary tumour and systemic I-131 meta-iodobenzyl-guanidine (mIBG). Sixteen months after treatment there was no clinical, radiological or biochemical evidence of residual disease and neurological function was restored. The case supports the use of combined treatment incorporating mIBG in patients with metastatic neuroendocrine tumours which demonstrate mIBG uptake.

  17. Severe hyponatremia in association with I(131) therapy in a patient with metastatic thyroid cancer.

    PubMed

    Nozu, Tsukasa; Yoshida, Yuri; Ohira, Masumi; Okumura, Toshikatsu

    2011-01-01

    Hyponatremia is a common clinical problem that results from various causes. Hypothyroidism is known to be one of the causes of this disorder. We report a case of metastatic thyroid cancer presenting with severe hyponatremia in association with hypothyroidism induced by pretreatment of I(131) therapy, such as a low-iodine diet and withdrawal of thyroid hormone. Serum arginine vasopressin (AVP) was elevated and urine osmolality was higher than that of serum. Saline infusion and thyroid hormone replacement normalized serum sodium and AVP. Inappropriate secretion of AVP in hypothyroid state was thought to be one of the causes of this hyponatremia.

  18. Calibration of the Accuscan II In Vivo System for I-131 Thyroid Counting

    SciTech Connect

    Orval R. Perry; David L. Georgeson

    2011-07-01

    This report describes the March 2011 calibration of the Accuscan II HpGe In Vivo system for I-131 thyroid counting. The source used for the calibration was an Analytics mixed gamma source 82834-121 distributed in an epoxy matrix in a Wheaton Liquid Scintillation Vial with energies from 88.0 keV to 1836.1 keV. The center of the detectors was position 64-feet from the vault floor. This position places the approximate center line of the detectors at the center line of the source in the thyroid tube. The calibration was performed using an RMC II phantom (Appendix J). Validation testing was performed using a Ba-133 source and an ANSI N44.3 Phantom (Appendix I). This report includes an overview introduction and records for the energy/FWHM and efficiency calibrations including verification counting. The Accuscan II system was successfully calibrated for counting the thyroid for I-131 and verified in accordance with ANSI/HPS N13.30-1996 criteria.

  19. Carcinoid tumors: CT and I-131 meta-iodo-benzylguanidine scintigraphy

    SciTech Connect

    Adolph, J.M.; Kimmig, B.N.; Georgi, P.; zum Winkel, K.

    1987-07-01

    The diagnostic value of computed tomography (CT) and iodine-131 meta-iodo-benzylguanidine (MIBG) scintiscanning was studied in nine patients with histologically proved carcinoid tumors of intestinal (n = 4), bronchial (n = 3), or thymic (n = 2) origin. CT scans clearly depicted the tumors and metastases in relation to surrounding vital structures but did not provide findings specific for carcinoids. The appearance on CT of an abdominal soft-tissue mass with a radiating pattern of linear densities was found to be highly suggestive of intestinal carcinoid tumors. I-131 MIBG scintiscans disclosed intense tracer uptake in the tumors and metastases in five patients. MIBG studies correctly depicted nine of nine tumor manifestations in intestinal carcinoids and four of six tumor manifestations in bronchus carcinoids. No MIBG concentration was found in thymus carcinoids. Because of its selective uptake mechanism, I-131 MIBG scintigraphy can allow specific detection and localization of neuroendocrine tumor tissue in patients with suspected carcinoid tumors. MIBG scintigraphy has diagnostic potential as a screening procedure in carcinoid tumors, especially those of intestinal origin.

  20. Neuroblastoma: Imaging evaluation by sequential Tc-99m MDP, I-131 MIBG, and Ga-67 citrate studies

    SciTech Connect

    Garty, I.; Friedman, A.; Sandler, M.P.; Kedar, A. )

    1989-07-01

    Fourteen children with histopathologically confirmed neuroblastoma underwent sequential correlative imaging studies using I-131 MIBG, Tc-99m MDP, and Ga-67 citrate during various stages of the disease. Of the patients 86% showed I-131 MIBG accumulation in the primary tumoral site, whereas 71% showed Tc-99m MDP and 79% Ga-67 citrate uptake. In 86% at least one of the two latter radiopharmaceuticals concentrated in the primary tumor. The use of all three radiopharmaceuticals raised the detection rate to 93%. Of the osseous or extraosseous metastases 100% were detected by Tc-99m MDP studies. The I-131 MIBG studies were positive in 71% of the osseous metastases and in 70% of the extraosseous metastases. No Ga-67 citrate uptake was demonstrated in osseous metastases, although one extraosseous lung metastasis concentrated this radiopharmaceutical. Tc-99m MDP bone imaging was the best method for diagnosing metastatic spread of the disease and for monitoring the results of treatment. Primary tumor uptake was best indicated by I-131 MIBG. Both Ga-67 citrate and I-131 MIBG were superior to Tc-99m MDP with regard to accurately demonstrating the extent of primary tumors. Only Tc-99m MDP indicated the relationship of these tumors to the kidneys and neighboring osseous structures, providing early screening of kidney compression. Ga-67 citrate study was mainly indicated in tumors with catecholamine depletion, which failed to concentrate the other two radiopharmaceuticals. I-131 MIBG proved especially useful in detecting neuroblastoma with negative Tc-99m MDP and Ga-67 citrate studies and also proved to be helpful with those cases in which I-131 MIBG was planned for therapy. The following strategy is suggested for evaluating neuroblastoma.

  1. Fetal radiation dose estimates for I-131 sodium iodide in cases where conception occurs after administration

    SciTech Connect

    Sparks, R.B.; Stabin, M.G.

    1999-01-01

    After administration of I-131 to the female patient, the possibility of radiation exposure of the embryo/fetus exists if the patient becomes pregnant while radioiodine remains in the body. Fetal radiation dose estimates for such cases were calculated. Doses were calculated for various maternal thyroid uptakes and time intervals between administration and conception, including euthyroid and hyperthyroid cases. The maximum fetal dose calculating was about 9.8E-03 mGy/MBq, which occurred with 100% maternal thyroid uptake and a 1 week interval between administration and conception. Placental crossover of the small amount of radioiodine remaining 90 days after conception was also considered. Such crossover could result in an additional fetal dose of 9.8E-05 mGy/MBq and a maximum fetal thyroid self dose of 3.5E-04 mGy/MBq.

  2. A PROGRESSIVE REACTION OCCURRING WITH A RADIOACTIVE HEMOLYSIN, SODIUM OLEATE-I131

    PubMed Central

    Ponder, Eric; Ponder, Ruth V.

    1958-01-01

    Sodium oleate reacts progressively with human red cells at pH 7. By progressive is meant a reaction which is not adequately described as reversible or irreversible; such reactions cannot be stopped once they are under way, and are probably associated with a more or less stable "internal" lysin phase at the cell surfaces. The uptake of the lysin and the effect of dilution on the uptake can be studied by converting sodium oleate into the radioactive form, sodium oleate-I131. The uptake is a parabolic function of the lysin initially present in the system, and the effect of a tenfold dilution of systems in which red cells have remained in contact with the lysin for 2 minutes is to reduce the lysin taken up at the cell surfaces twofold. The lysin rapidly forms a relatively stable layer at the cell interfaces, and this layer is little affected by the dilution of the system as a whole. PMID:13491825

  3. Medically-derived I-131: a potential tool for understanding the fate of wastewater nitrogen in aquatic systems

    NASA Astrophysics Data System (ADS)

    Rose, P. S.; Smith, J. P.; Aller, R. C.; Cochran, J. K.; Swanson, R. L.; Murthy, S. N.; Coffin, R. B.

    2010-12-01

    Iodine-131(t1/2 = 8 days) has been measured in Potomac River water and sediments in the vicinity of the Blue Plains Water Pollution Control Plant (WPCP), Washington, DC. The source of I-131 is medical, where it is commonly used to treat thyroid cancer and hyperthyroidism. Iodine is metabolized by patients and eliminated primarily in urine. While other medical radioisotopes may enter the environment via sewage effluent, the nature and quantity of treatments using I-131 cause it to account for much of the radioactivity in sewage effluent. Natural iodine in aquatic systems is biologically cycled similar to other nutrients, such as nitrogen. Iodine-131 concentrations measured in sewage effluent from Blue Plains WPCP and in the Potomac River suggest a relatively continuous discharge of this isotope. Dissolved I-131 shows a strong, positive correlation with δ15N values of nitrate in the river. The range of I-131 concentrations detected in surface waters is 0.18 ± 0.01 to 0.68 ± 0.02 Bq/L. Surface water δ15NO3 values ranged from 8.7 ± 0.3 to 33.4 ± 7.3 ‰ with NO3+NO2 concentrations between 0.38 ± 0.02 and 2.79 ± 0.13 mgN/L. Sediment profiles of particulate I-131 and δ15N indicate rapid mixing or sedimentation and in many cases remineralization of a heavy nitrogen source consistent with wastewater nitrogen. Iodine-131 concentrations in sediments ranged from 1.31 ± 0.8 to 117 ± 2 Bq/kg dry weight. Values of δ15N in sediments ranged from 4.7 ± 0.1 ‰ to 9.3 ± 0.1 ‰. We propose that I-131 coupled with δ15N can be an excellent tracer for the short-term fate of wastewater nitrogen in this system. However, the utility of I-131 as a tracer is not limited to use in the Potomac River. Other studies have documented the presence of I-131 in several aquatic systems and continuous discharges of this radioisotope in sewage effluent are likely to be widespread in urban environments.

  4. Use of fusion images of I-131 metaiodobenzylguanidine, SPECT, and magnetic resonance studies to identify a malignant pheochromocytoma.

    PubMed

    Fujita, A; Hyodoh, H; Kawamura, Y; Kanegae, K; Furuse, M; Kanazawa, K

    2000-06-01

    Pheochromocytoma is a chromaffin tumor in which 10% are extra-adrenal and 10% are malignant. I-131 metaiodobenzylguanidine (MIBG) scintigraphy has an important role in the identification of these tumors and investigation of metastatic lesions. The authors describe a 36-year-old woman who underwent resection of a malignant left adrenal pheochromocytoma who was thought to have metastases in the liver and para-aortic lymph nodes. Fusion images of I-131 MIBG SPECT and magnetic resonance studies were obtained to properly identify the metastatic lesions. These fusion images helped greatly in subsequent surgery.

  5. Sialadenitis following low dose I-131 diagnostic thyroid scan with Thyrogen® (recombinant human thyroid stimulating hormone - thyrotropin alfa)

    PubMed Central

    Gonzalez, Marta E; Muttikkal, Thomas Jose Eluvathingal; Rehm, Patrice K

    2015-01-01

    Salivary dysfunction and sialadenitis are well known complications of radioiodine treatment for thyroid cancer. The parotid gland is more frequently affected and the salivary gland injury is dose related. The symptoms may develop shortly after therapeutic Iodine 131(I-131) administration or months later and progress with time. The development of unilateral parotiditis following a low dose, diagnostic I-131 scan performed following Thyrogen stimulation in a patient without prior history of sialadenitis is rare in our experience, and has not been reported in the medical literature. PMID:26622936

  6. Iodine-131 metaiodobenzylguanidine (I-131 MIBG) diagnosis and therapy of pheochromocytoma and paraganglioma: current problems, critical issues and presentation of a sample case.

    PubMed

    Castellani, M R; Aktolun, C; Buzzoni, R; Seregni, E; Chiesa, C; Maccauro, M; Aliberti, G L; Vellani, C; Lorenzoni, A; Bombardieri, E

    2013-06-01

    Iodine-131 metaiodobenzylguanidine (I-131 MIBG) has been used for the diagnosis and treatment of malignant pheochromocytomas (PHEO) and paragangliomas (PGL) since 1980's. Despite increasing amount of experience with iodine-131 (I-131) MIBG therapy, many important questions still exist. In this article, we will discuss the current problems learned from clinical experience in diagnosis and therapy of PHEO/PGL with I-131 MIBG, and present a sample case to emphasize the critical aspects for an optimal treatment strategy.

  7. Implementation of iodine biokinetic model for interpreting I-131 contamination in breast milk after the Fukushima nuclear disaster

    NASA Astrophysics Data System (ADS)

    Tani, Kotaro; Kurihara, Osamu; Kim, Eunjoo; Yoshida, Satoshi; Sakai, Kazuo; Akashi, Makoto

    2015-07-01

    After the accident at the Fukushima Daiichi Nuclear Power Plant run by Tokyo Electric Power Company in 2011, breast milk samples obtained from volunteers living in Fukushima and neighboring prefectures were examined and small amounts of I-131 (2.2-36.3 Bq/kg) were detected in some samples. In this work, the I-131 concentrations in breast milk from nursing mothers in Ibaraki prefecture were calculated based on the iodine biokinetic model during lactation together with time-variable intake scenarios by inhalation of ambient air and ingestion of tap water, using the authors’ code. The calculated I-131 concentrations in breast milk generally agreed with those measured for the volunteers. Based on the results, thyroid equivalent doses to breast-fed infants were estimated for each place of residence of the volunteers on the assumption that these infants consumed 800 ml of breast milk every day, resulting in 10-11 mSv for Mito and Kasama cities and 1.1-1.8 mSv for Tsukuba and Moriya cities. It was suggested that breast milk consumption could be a major contributor to internal dose of breast-fed infants in areas with mild I-131 pollution; however, further studies considering personal behavior surveys would be necessary to estimate individual doses.

  8. Implementation of iodine biokinetic model for interpreting I-131 contamination in breast milk after the Fukushima nuclear disaster

    PubMed Central

    Tani, Kotaro; Kurihara, Osamu; Kim, Eunjoo; Yoshida, Satoshi; Sakai, Kazuo; Akashi, Makoto

    2015-01-01

    After the accident at the Fukushima Daiichi Nuclear Power Plant run by Tokyo Electric Power Company in 2011, breast milk samples obtained from volunteers living in Fukushima and neighboring prefectures were examined and small amounts of I-131 (2.2–36.3 Bq/kg) were detected in some samples. In this work, the I-131 concentrations in breast milk from nursing mothers in Ibaraki prefecture were calculated based on the iodine biokinetic model during lactation together with time-variable intake scenarios by inhalation of ambient air and ingestion of tap water, using the authors’ code. The calculated I-131 concentrations in breast milk generally agreed with those measured for the volunteers. Based on the results, thyroid equivalent doses to breast-fed infants were estimated for each place of residence of the volunteers on the assumption that these infants consumed 800 ml of breast milk every day, resulting in 10–11 mSv for Mito and Kasama cities and 1.1–1.8 mSv for Tsukuba and Moriya cities. It was suggested that breast milk consumption could be a major contributor to internal dose of breast-fed infants in areas with mild I-131 pollution; however, further studies considering personal behavior surveys would be necessary to estimate individual doses. PMID:26198990

  9. Empirical shielding design data for facilities administering I131 for thyroid carcinoma.

    PubMed

    Groth, M J

    1998-12-01

    Retrospective review of the records for 434 post thyroidectomy patients receiving I131 therapy for thyroid carcinoma revealed approximately 75% of the patients were discharged within 48 hours and 90% within 72 hours. Criterion for discharge was an external radiation dose below 25 muSv/hr, measured at one metre anterior to the patient's neck. The time-averaged average dose rate one metre anterior to the neck of a typical patient during the isolation period was 72 muSv/hr, with 90% of the patients below 82 muSv/hr. After correcting for the effects of patient size and scatter, the effective design dose rate from a patient in an isolation room treating two or three patients/week is 105 muSv.m2.hr-1, or 75 muSv.m.hr-1 where only one patient is treated each week. Concrete is the most economical shielding material, with 190 mm filled concrete block walls and 150 mm concrete floors as the minimum recommended shielding for a radioiodine therapy suite. Additional shielding will be required if the suite adjoins (including areas immediately above and below) areas with a high occupancy factor.

  10. Application of a medium-energy collimator for I-131 imaging after ablation treatment of differentiated thyroid cancer.

    PubMed

    Kobayashi, Masato; Wakabayashi, Hiroshi; Kayano, Daiki; Konishi, Takahiro; Kojima, Hironori; Yoneyama, Hiroto; Okuda, Koichi; Tsushima, Hiroyuki; Onoguchi, Masahisa; Kawai, Keiichi; Kinuya, Seigo

    2014-07-01

    High-energy (HE) collimators are usually applied for I-131 imaging after ablation treatment of differentiated thyroid cancer (DTC). However, purchase of HE collimators has been avoided in many nuclear medicine departments because the HE collimators are more expensive than other collimators. In this study, we compared the I-131 imaging using HE- and medium-energy (ME) collimators, which is more versatile than HE collimators. To simulate DTC patients with extra-thyroid beds, a phantom of acrylic containers containing I-131 was used. To simulate patients with thyroid beds, four phantoms representing extra-thyroid beds were arranged around the phantom representing normal thyroid tissues. Patients administered 1.11 or 3.70 GBq NaI-131 were also evaluated. Whole-body imaging and SPECT imaging of the phantoms and patients performed using HE-general-purpose (HEGP) and ME-low-penetration (MELP) collimators, and full-width at half maximum (FWHM) and percent coefficient of variation (%CV) were measured. In the extra-thyroid beds, FWHM and %CV with MELP were negligibly different from those with HEGP in whole-body imaging. Although FWHM with MELP was a little different from that with HEGP in SPECT imaging, %CV with MELP was significantly higher than that with HEGP. In the thyroid beds, only an extra-thyroid bed including higher radioactivity was identified in whole-body imaging with both collimators. Although SPECT images with MELP could not clarify extra-thyroid beds with low radioactivity, HEGP could identify them. In patients, although some whole-body images with MELP could not detect extra-thyroid beds, whole-body imaging with HEGP and SPECT imaging with both collimators could detect them. Although HEGP is the best collimator for I-131 imaging, MELP is applicable for not only whole-body imaging but also SPECT imaging.

  11. Use of radioactive iodine I-131 and monitoring of radioactivity in patients with chronic kidney disease on haemodialysis.

    PubMed

    Gallegos-Villalobos, Angel; García-López, Fernando; Escalada, Carmen; Ortiz, Juan J; Cardona, Jorge; Medina, Amparo; Portolés, José

    2014-05-21

    Thyroid carcinoma is a neoplasia with a higher incidence in patients with chronic kidney disease. In recent years advances have been made in diagnostic and therapeutic trials. Dialysis patients are a particular group, their cancer being detected indirectly in the study of secondary hyperparathyroidism and during the study prior to renal transplantation. Thyroidectomy is the definitive treatment, but in patients with risk of recurrence, ablative therapy is required using radioactive iodine I-131, which is predominantly eliminated by renal excretion, therefore its use in patients on dialysis poses a problem in terms of dosage. Two cases are presented of patients on haemodialysis undergoing radioablation with radioactive iodine I-131, which with multidisciplinary treatment had the expected results in the patients.

  12. Sialoendoscopy combined with an internal stent and postoperative massage as a comprehensive treatment of delayed I(131)-induced parotitis.

    PubMed

    Meng, Q; Fang, W; Long, X; Deng, M; Li, J; Ke, J

    2017-09-01

    A common complication of radioiodine (I(131)) treatment of thyroid cancer is parotitis. Here we describe our clinical experience in treating delayed I(131)-induced parotitis using sialoendoscopy together with an internal stent and postoperative massage. In this retrospective cohort study we reviewed 32 patients who were treated in that way under general anaesthesia between July 2010 and March 2015. Their age, sex, and the time to development of the parotitis were collected from the hospital's database. All patients were evaluated using a visual analogue scale (VAS), sialography, and computed tomography preoperatively. The analyses of VAS scores were made during postoperative follow-up visits. We used the paired Student's t test and one-way ANOVA to assess the significance of differences, and probabilities of < 0.05 were accepted as significant. The mean (SD) age of the 32 patients was 50 (11) years, and they developed symptoms of delayed parotitis after a mean (SD) of 12 (11) months. The mean time between treatment with I(131) and sialoendoscopy was 26 (10) months. Ductal stenosis was the most common sialoendoscopic feature, together with mucous plugs and fibrosis. Fifty of the 56 ducts were successfully dilated by sialoendoscopy, and VAS scores significantly decreased from a preoperative 7.3 (1.1) to a postoperative 3.3 (2.1) (p=0.000) during follow-up of 3 - 41 months. Sialoendoscopic interventions combined with an internal stent and postoperative massage may be optimal comprehensive treatment for delayed I(131)-induced parotitis. Copyright © 2017 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

  13. Three-dimensional cellular dosimetry of I-131 mIBG in neuroblastoma with EGS4 Monte Carlo code

    SciTech Connect

    Gouriou, J.; Ricard, M.; Lumbroso, J.; Aubert, B. |

    1995-05-01

    The adequate distribution of radiation dose to tumor cells is the most important factor for the outcome of internal (metabolic) radiotherapy. This study investigates the dosimetry of I-131 meta-iodobenzyl-guanidine at the cellular level in neuroblastoma. We developed a program based on the EGS4 Monte Carlo code allowing the computation of basic dosimetric parameters such as absorbed and cumulated fractions, scaled dose point kernels and dose rates, especially for radionuclides with therapeutic potential. It can be applied to various types of 3-D radionuclide tumor distributions. Geometrical parameters and mIBG uptake in xenografted tumors (nude mice, SK-N-SH) were obtained from micro-autoradiographies and SIMS microscopy images. The tumor could be simulated by a spheroid (500 {mu}m in radius) made up of spherical cells (9 {mu}m in radius) with a 1 {mu}m cytoplasm. Among this cell population, only 3% bound mIBG with local maximal rates of up to 16%. The radiation doses were calculated for I-131, since this radionuclide is the most widely used for labelling mIBG for a therapeutic potential. It can be applied to various types of 3-D radionuclide tumor distributions. Geometrical parameters and mIBG uptake in xenografted tumors (nude mice, SK-N-SH) were obtained from micro-autoradiographies and SIMS microscopy images.

  14. RET/PTC and PAX8/PPARγ chromosomal rearrangements in post-Chernobyl thyroid cancer and their association with I-131 radiation dose and other characteristics

    PubMed Central

    Leeman-Neill, Rebecca J.; Brenner, Alina V.; Little, Mark P.; Bogdanova, Tetiana I.; Hatch, Maureen; Zurnadzy, Liudmyla Y.; Mabuchi, Kiyohiko; Tronko, Mykola D.; Nikiforov, Yuri E.

    2012-01-01

    Background Childhood exposure to I-131 from the 1986 Chernobyl accident led to a sharp increase in papillary thyroid carcinoma (PTC) incidence in regions surrounding the reactor. Data concerning the association between genetic mutations in PTCs and individual radiation doses are limited. Methods We performed mutational analysis of 62 PTCs diagnosed in a Ukrainian cohort of patients who were <18 y.o. in 1986 and received 0.008-8.6 Gy of I-131 to the thyroid and explored associations between mutation types and I-131 dose and other characteristics. Results RET/PTC rearrangements were most common (35%), followed by BRAF (15%) and RAS (8%) point mutations. Two tumors carrying PAX8/PPARγ rearrangement were identified. We found a significant negative association with I-131 dose for BRAF and RAS point mutations and a significant concave association with I-131 dose, with an inflection point at 1.6 Gy and odds ratio 2.1, based on a linear-quadratic model for RET/PTC and PAX8/PPARγ rearrangements. The trends with dose were significantly different between tumors with point mutations and rearrangements. Compared to point mutations, rearrangements were associated with residence in the relatively iodine deficient Zhytomyr region, younger age at exposure or surgery, and male gender. Conclusions Our results provide the first demonstration of PAX8/PPARγ rearrangements in post-Chernobyl tumors and show different associations for point mutations and chromosomal rearrangements with I-131 dose and other factors. These data support the relationship between chromosomal rearrangements, but not point mutations, and I-131 exposure and point to a possible role of iodine deficiency in generation of RET/PTC rearrangements in these patients. PMID:23436219

  15. Marrow Ablative and Immunosuppressive Effects of I-131-anti-CD45 Antibody in Congenic and H2-Mismatched Murine Transplant Models

    SciTech Connect

    Matthews, D. C.; Martin, P J.; Nourigat, C.; Appelbaum, F. R.; Fisher, Darrell R. ); Bernstein, I. D.

    1998-12-01

    Targeted hematopoietic irradiation delivered by I-131-anti-CD45 antibody has been combined with conventional marrow transplant preparative regimens in an effort to decrease relapse. Before increasing the proportion of therapy delivered by radiolabeled antibody, the myeloablative and immunosuppressive effects of such low dose rate irradiation must be quantitated. We have examined the ability of I-131-anti-CD45 antibody to facilitate engraftment in Ly5-congenic and H2-mismatched murine marrow transplant models. Recipient B6-Ly5-a mice were treated with 30F11 antibody labeled with 0.1 to 1.5 mCi I-131 and/or total body irradiation (TBI), followed by T-cell-depleted marrow from Ly5-b-congenic (C57BL/6) or H2-mismatched (BALB/c) donors. Engraftment was achieved readily in the Ly5-congenic setting, with greater than 80% donor granulocytes and T cells after 0.5 mCi I-131 (estimated 17 Gy to marrow) or 8 Gy TBI. A higher TBI dose (14 Gy) was required to achieve engraftment of H2-mismatched mar row, and engraftment occurred in only 3 of 11 mice receiving 1.5 mCi I-131 delivered by anti-CD45 antibody. Engraftment of H2-mismatched marrow was achieved in 22 of 23 animals receiving 0.75 mCi I-131 delivered by anti-CD45 antibody combined with 8 Gy TBI. Thus, targeted radiation delivered via I-131-anti-CD45 antibody can enable engraftment of congenic marrow and can partially replace TBI when transplanting T-cell-depleted H2-mismatched marrow.

  16. Second malignancies in patients with differentiated thyroid carcinoma treated with low and medium activities of radioactive I-131

    PubMed Central

    PICIU, DOINA; PESTEAN, CLAUDIU; BARBUS, ELENA; LARG, MARIA IULIA; PICIU, ANDRA

    2016-01-01

    Background and aim This study aimed at determining whether there is a risk regarding the development of second primary malignancies after patient exposure to the low and medium radioiodine activity used during the treatment of differentiated thyroid cancers (DTC). Methods Second primary malignancies that occurred after DTC were detected in 1,990 patients treated between 1970 and 2003. The mean long-term follow-up period was 182 months. Results Radioiodine I-131was administrated at a mean dose of 63.2 mCi. There were 93 patients with at least one second primary malignancy. The relative risk of development of second malignancy in DTC patients was increased (p<0.0001) for breast, uterine and ovarian cancers compared with the general population. Conclusions The overall risk concerning the development of second primary malignancies was related to the presence of DTC, but not to exposure to the low and medium activities of radioiodine administered as adjuvant therapy. PMID:27547058

  17. Comparison of internal dosimetry factors for three classes of adult computational phantoms with emphasis on I-131 in the thyroid.

    PubMed

    Lamart, Stephanie; Bouville, Andre; Simon, Steven L; Eckerman, Keith F; Melo, Dunstana; Lee, Choonsik

    2011-11-21

    The S values for 11 major target organs for I-131 in the thyroid were compared for three classes of adult computational human phantoms: stylized, voxel and hybrid phantoms. In addition, we compared specific absorbed fractions (SAFs) with the thyroid as a source region over a broader photon energy range than the x- and gamma-rays of I-131. The S and SAF values were calculated for the International Commission on Radiological Protection (ICRP) reference voxel phantoms and the University of Florida (UF) hybrid phantoms by using the Monte Carlo transport method, while the S and SAF values for the Oak Ridge National Laboratory (ORNL) stylized phantoms were obtained from earlier publications. Phantoms in our calculations were for adults of both genders. The 11 target organs and tissues that were selected for the comparison of S values are brain, breast, stomach wall, small intestine wall, colon wall, heart wall, pancreas, salivary glands, thyroid, lungs and active marrow for I-131 and thyroid as a source region. The comparisons showed, in general, an underestimation of S values reported for the stylized phantoms compared to the values based on the ICRP voxel and UF hybrid phantoms and relatively good agreement between the S values obtained for the ICRP and UF phantoms. Substantial differences were observed for some organs between the three types of phantoms. For example, the small intestine wall of ICRP male phantom and heart wall of ICRP female phantom showed up to eightfold and fourfold greater S values, respectively, compared to the reported values for the ORNL phantoms. UF male and female phantoms also showed significant differences compared to the ORNL phantom, 4.0-fold greater for the small intestine wall and 3.3-fold greater for the heart wall. In our method, we directly calculated the S values without using the SAFs as commonly done. Hence, we sought to confirm the differences observed in our S values by comparing the SAFs among the phantoms with the thyroid as a

  18. Comparison of internal dosimetry factors for three classes of adult computational phantoms with emphasis on I-131 in the thyroid

    NASA Astrophysics Data System (ADS)

    Lamart, Stephanie; Bouville, Andre; Simon, Steven L.; Eckerman, Keith F.; Melo, Dunstana; Lee, Choonsik

    2011-11-01

    The S values for 11 major target organs for I-131 in the thyroid were compared for three classes of adult computational human phantoms: stylized, voxel and hybrid phantoms. In addition, we compared specific absorbed fractions (SAFs) with the thyroid as a source region over a broader photon energy range than the x- and gamma-rays of I-131. The S and SAF values were calculated for the International Commission on Radiological Protection (ICRP) reference voxel phantoms and the University of Florida (UF) hybrid phantoms by using the Monte Carlo transport method, while the S and SAF values for the Oak Ridge National Laboratory (ORNL) stylized phantoms were obtained from earlier publications. Phantoms in our calculations were for adults of both genders. The 11 target organs and tissues that were selected for the comparison of S values are brain, breast, stomach wall, small intestine wall, colon wall, heart wall, pancreas, salivary glands, thyroid, lungs and active marrow for I-131 and thyroid as a source region. The comparisons showed, in general, an underestimation of S values reported for the stylized phantoms compared to the values based on the ICRP voxel and UF hybrid phantoms and relatively good agreement between the S values obtained for the ICRP and UF phantoms. Substantial differences were observed for some organs between the three types of phantoms. For example, the small intestine wall of ICRP male phantom and heart wall of ICRP female phantom showed up to eightfold and fourfold greater S values, respectively, compared to the reported values for the ORNL phantoms. UF male and female phantoms also showed significant differences compared to the ORNL phantom, 4.0-fold greater for the small intestine wall and 3.3-fold greater for the heart wall. In our method, we directly calculated the S values without using the SAFs as commonly done. Hence, we sought to confirm the differences observed in our S values by comparing the SAFs among the phantoms with the thyroid as a

  19. Cellular and molecular effects of beta radiation from I-131 on human tumor cells: a comparison with gamma radiation.

    PubMed

    Kumar, Chandan; Jayakumar, Sundarraj; Pandey, Badri N; Samuel, Grace; Venkatesh, Meera

    2014-01-01

    To study the comparative effects of beta radiation emitted from Na(131)I with equivalent dose of (60)Co γ- radiation across a range of tumor types and underlying mechanism of cytotoxicity. Different tumor cell lines of various tissue origin viz. Raji, U937, A431 and MCF-7 were irradiated with beta radiation emitted from Na(131)I and equivalent dose of (60)Co γ- radiation (0.4 Gy). Cellular toxicity and apoptosis study were carried out in four cell lines and the effects were compared. Gene expression studies of P21, RAD51 and BAX genes were analyzed by q-PCR after β- and γ-irradiation. Cell viability (trypan blue assay) and apoptosis (DNA fragmentation and cleavage of PARP assays) studies for both types of radiation showed that among the four cell lines, A431 is most radio-resistant while MCF-7 and U937 are moderately radiation resistant and Raji cells showed maximum radiosensitivity. However, irradiation of cells with beta radiation from I-131 resulted in enhanced toxicity and apoptosis in tumor cells compared to equivalent dose of γ- rays. Gene expression studies in Raji cells showed difference in magnitude and kinetics of RAD51 and P21 expression after β- and γ-irradiation. Our results showed higher efficacy of beta radiation in induction of tumor cell cytotoxicity and apoptosis compared to an equivalent dose of γ-radiation, which may be associated with differential DNA damage and subsequent repair kinetics in tumor cells after these radiations.

  20. False Positive Findings on I-131 WBS and SPECT/CT in Patients with History of Thyroid Cancer: Case Series

    PubMed Central

    Hannoush, Zeina C.; Palacios, Juan D.; Kuker, Russ A.

    2017-01-01

    Introduction. Although whole body scan (WBS) with I-131 is a highly sensitive tool for detecting normal thyroid tissue and metastasis of differentiated thyroid cancer (DTC), it is not specific. Additional information, provided by single photon emission computed tomography combined with X-ray computed tomography (SPECT/CT) and by the serum thyroglobulin level, is extremely useful for the interpretation of findings. Case Presentation. We report four cases of false positive WBS in patients with DTC: ovarian uptake corresponding to an endometrioma, scrotal uptake due to a spermatocele, rib-cage uptake due to an old fracture, and hepatic and renal uptake secondary to a granuloma and simple cyst, respectively. Conclusions. Trapping, organification, and storage of iodine are more prominent in thyroid tissue but not specific. Physiologic sodium-iodine symporter expression in other tissues explains some, but not all, of the WBS false positive cases. Other proposed etiologies are accumulation of radioiodine in inflamed organs, metabolism of radiodinated thyroid hormone, presence of radioiodine in body fluids, and contamination. In our cases nonthyroidal pathologies were suspected since the imaging findings were not corroborated by an elevated thyroglobulin level, which is considered a reliable tumor marker for most well-differentiated thyroid cancers. Clinicians should be aware of the potential pitfalls of WBS in DTC to avoid incorrect management. PMID:28246564

  1. Radionuclide I-131 Labeled Albumin-Paclitaxel Nanoparticles for Synergistic Combined Chemo-radioisotope Therapy of Cancer

    PubMed Central

    Tian, Longlong; Chen, Qian; Yi, Xuan; Wang, Guanglin; Chen, Jie; Ning, Ping; Yang, Kai; Liu, Zhuang

    2017-01-01

    Development of biocompatible/biodegradable materials with multiple functionalities via simple methods for cancer combination therapy has attracted great attention in recent years. Herein, paclitaxel (PTX), a popular anti-tumor chemotherapeutic drug, is used to induce the self-assembly of human serum albumin (HSA) pre-labeled with radionuclide I-131, obtaining 131I-HSA-PTX nanoparticles for combined chemotherapy and radioisotope therapy (RIT) of cancer. Such 131I-HSA-PTX nanoparticles show prolonged blood circulation time, high tumor specific uptake and excellent intra-tumor penetration ability. Interestingly, as revealed by in vivo photoacoustic imaging and ex vivo immunofluorescence staining, PTX delivered into the tumor by HSA-nanoparticle transportation can remarkably enhance the tumor local oxygen level and suppress the expression of HIF-1α, leading to greatly relieved tumor hypoxia. As the results, the combined in vivo chemotherapy & RIT with 131I-HSA-PTX nanoparticles in the animal tumor model offers excellent synergistic therapeutic efficacy, likely owing to the greatly modulated tumor microenvironment associated with PTX-based chemotherapy. Therefore, in this work, a simple yet effective therapeutic agent is developed for synergistic chemo-RIT of cancer, promising for future clinic translations in cancer treatment. PMID:28255354

  2. Thymic uptake after high-dose I-131 treatment in patients with differentiated thyroid carcinoma: a brief review of possible causes and management.

    PubMed

    Arce, Manrique Borbón; Molina, Teresa Cambil; Hernández, Tomás Martín; de la Cinta Calvo Morón, María; Herrero, Cristina Hernández; De La Riva Pérez, Pablo Antonio; Montaño, Juan Castro

    2015-01-01

    To report five cases of patients diagnosed with differentiated thyroid carcinoma (DTC) with uptake in the thymic area after high-dose treatment with I-131 and to evaluate the potential causes and therapeutic management. Five cases of young female patients with a mean age of 36.6 years (24-43) who had been treated with a mean dose of 106 mCi of I-131 (100-150 mCi) showing tracer uptake in the thymic area are reported. An I-131 whole-body scan (131I-WBS) was performed 7 days after therapeutic dose administration to each patient. Anterior and posterior planar images, followed by SPECT/CT of the head, neck and superior mediastinum were acquired in all patients. Thyroglobulin levels were measured with and without hormone replacement therapy in all cases. Samples taken from the superior mediastinum were sent to pathology for analysis, which confirmed the presence of thymic tissue. Two patients underwent elective total thymectomy due to the gross characteristics of the gland, local 131-I uptake, and high thyroglobulin levels. The remaining three patients had already undergone thymectomy as part of neck dissection during initial surgery, and no further invasive interventions were therefore performed. Pathological examination revealed no metastases in these five patients. Thymus visualization in young patients after administration of therapeutic doses of I-131 seems to be a more common finding than usually thought. Absence of metastasis in the thymus despite high thyroglobulin levels was confirmed in all cases. Based on these results, we suggest that a more expectant and less aggressive therapeutic approach could be used. We also suggest that I-131 therapy for DTC should be considered in classification of the potential causes of true thymic hyperplasia in the subgroup of patients recovering from a stressor. Copyright © 2013 SEEN. Published by Elsevier Espana. All rights reserved.

  3. Comparison of I-131 radioimmunotherapy tumor dosimetry: unit density sphere model versus patient-specific Monte Carlo calculations.

    PubMed

    Howard, David M; Kearfott, Kimberlee J; Wilderman, Scott J; Dewaraja, Yuni K

    2011-10-01

    High computational requirements restrict the use of Monte Carlo algorithms for dose estimation in a clinical setting, despite the fact that they are considered more accurate than traditional methods. The goal of this study was to compare mean tumor absorbed dose estimates using the unit density sphere model incorporated in OLINDA with previously reported dose estimates from Monte Carlo simulations using the dose planning method (DPMMC) particle transport algorithm. The dataset (57 tumors, 19 lymphoma patients who underwent SPECT/CT imaging during I-131 radioimmunotherapy) included tumors of varying size, shape, and contrast. OLINDA calculations were first carried out using the baseline tumor volume and residence time from SPECT/CT imaging during 6 days post-tracer and 8 days post-therapy. Next, the OLINDA calculation was split over multiple time periods and summed to get the total dose, which accounted for the changes in tumor size. Results from the second calculation were compared with results determined by coupling SPECT/CT images with DPM Monte Carlo algorithms. Results from the OLINDA calculation accounting for changes in tumor size were almost always higher (median 22%, range -1%-68%) than the results from OLINDA using the baseline tumor volume because of tumor shrinkage. There was good agreement (median -5%, range -13%-2%) between the OLINDA results and the self-dose component from Monte Carlo calculations, indicating that tumor shape effects are a minor source of error when using the sphere model. However, because the sphere model ignores cross-irradiation, the OLINDA calculation significantly underestimated (median 14%, range 2%-31%) the total tumor absorbed dose compared with Monte Carlo. These results show that when the quantity of interest is the mean tumor absorbed dose, the unit density sphere model is a practical alternative to Monte Carlo for some applications. For applications requiring higher accuracy, computer-intensive Monte Carlo calculation is

  4. Immunoscintigraphy of human pancreatic carcinoma in nude mice with I-131-F(ab')/sub 2/-fragments of monoclonal antibodies

    SciTech Connect

    Senekowitsch, R.; Maul, F.D.; Wenisch, H.J.C.; Kriegel, H.; Hor, G.

    1985-05-01

    In the present study radioiodinated F(ab')/sub 2/-fragments of CA19-9 and antibody that reacts specifically with human gastrointestinal cancer were examined for their ability to detect human pancreatic carcinoma hosted in nude mice. Tumor-bearing mice received 80..mu..Ci of I-131-F(ab')/sub 2/ with a specific activity of 1.8..mu..Ci/..mu..g. All mice were imaged after the injection and every 24hr up to 6 days. The retained radioactivity was also registered with a whole-body counter immediately after imaging. As a control F(ab's)/sub 2/ of a nonspecific antibody were administered in parallel to another group of animals bearing the same tumor. Three animals of each group were killed at 1,2,4 and 8 days for determination of the distribution of both labeled antibody-fragments. On scintigraphic images obtained with the CA19-9-F(ab')/sub 2/ the tumors could be visualized 24hr after injection, the best dilineation however was achieved 96hr p.i.. The biodistribution data exhibited a more rapid blood clearance for the specific fragments compared to that for the unspecific ones. Tumors showed an increase in uptake up to 48hr reaching 1.7% of the injected dose per gram, declining to values of 0.08%/g at day 6 p.i.. The highest tumor-to-blood ratios were found after 96h. They were 7 for the CA19-9-fragments compared to 1.5 for the unspecific fragments. The whole body counting revealed a more rapid excretion for the fragments of the specific monoclonal antibodies than for the unspecific ones. In summary the authors were able to show that CA19-9-F(ab')/sub 2/-fragments can be used for immunodetection of human pancreatic carcinoma hosted in nude mice.

  5. Inverse relationship between cardiac accumulation of meta-(/sup 131/I)iodobenzylguanidine (I-131 MIBG) and circulation catecholamines in suspected pheochromocytoma

    SciTech Connect

    Nakajo, M.; Shapiro, B.; Glowniak, J.; Sisson, J.C.; Beierwaltes, W.H.

    1983-12-01

    Heart intensity (HI) in the 24- and 48-hr images of meta-(/sup 131/I)iodobenzylguanidine (I-131 MIBG), a pheochromocytoma-seeking guanethidine analog, were compared with concentrations of plasma and urinary catecholamines and their metabolites in nonpheochromocytoma and pheochromocytoma patients. HI was inversely related to plasma concentrations and urinary excretion rates of the hormones. Plasma norepinephrine had the highest inverse correlation with HI (r = -0.73 at 24 hr, -0.63 at 48 hr) and urinary metanephrine the lowest (r = -0.23 at 24 hr, -0.28 at 48 hr). A similar relationship was observed in the intensity of salivary-gland visualization, but with less marked variations. HI was much higher in ninpheochromocytoma patients than in pheochromocytoma patients. HI in an I-131 MIGB image provides useful information in the diagnosis of pheochromocytoma, and may provide a tool for the study of the influence of catecholamines on the heart.

  6. Tumor dosimetry for I-131 trastuzumab therapy in a Her2+ NCI N87 xenograft mouse model using the Siemens SYMBIA E gamma camera with a pinhole collimator

    NASA Astrophysics Data System (ADS)

    Lee, Young Sub; Kim, Jin Su; Deuk Cho, Kyung; Kang, Joo Hyun; Moo Lim, Sang

    2015-07-01

    We performed imaging and therapy using I-131 trastuzumab and a pinhole collimator attached to a conventional gamma camera for human use in a mouse model. The conventional clinical gamma camera with a 2-mm radius-sized pinhole collimator was used for monitoring the animal model after administration of I-131 trastuzumab The highest and lowest radiation-received organs were osteogenic cells (0.349 mSv/MBq) and skin (0.137 mSv/MBq), respectively. The mean coefficients of variation (%CV) of the effective dose equivalent and effective dose were 0.091 and 0.093 mSv/MBq respectively. We showed the feasibility of the pinholeattached conventional gamma camera for human use for the assessment of dosimetry. Mouse dosimetry and prediction of human dosimetry could be used to provide data for the safety and efficacy of newly developed therapeutic schemes.

  7. A simple low-cost of liquid I-131 dispenser for routine radiopharmaceutical dispensing at nuclear medicine department, Institut Kanser Negara

    SciTech Connect

    Said, M. A.; Suhaimi, N. E. F.; Ashhar, Z. N.; Zainon, R.

    2016-01-22

    In routine radiopharmaceutical Iodine-131 ({sup 131}I) dispensing, the amount of radiation dose received by the personnel depends on the distance between the personnel and the source, the time spent manipulating the source and the amount of shielding used to reduce the dose rate from the source. The novel iRAD-I131 dispenser using recycle {sup 131}I liquid lead pot will lead into low cost production, less maintenance and low dose received by the personnel that prepared the {sup 131}I. The new fabricated of low cost {sup 131}I dispenser was tested and the dose received by personnel were evaluated. The body of lead material is made from 2.5 cm lead shielded coated with epoxy paint to absorb the radiation dose up to 7.4 GBq of {sup 131} I. The lead pot was supported with two stainless steel rod. The Optically Stimulated Luminescence (OSL) nanodot was used in this study to measure the dose rate at both extremities for every personnel who prepared the {sup 131}I. Each OSL nanodot was attached at the fingertip. Three different personnel (experienced between one to ten years above in preparing the radiopharmaceuticals) were participated in this study. The average equivalent dose at right and left hand were 122.694 ± 121.637 µSv/GBq and 77.281 ± 62.146 µSv/GBq respectively. This study found that the dose exposure received using iRAD-I131 was less up to seven times compared to the conventional method. The comparison of experimental data using iRAD-I131 and established radiopharmaceutical dispenser was also discussed. The innovation of {sup 131}I dispenser is highly recommended in a small radiopharmaceutical facility with limited budget. The novel iRAD-I131 enables implementation of higher output liquid dispensing with low radiation dose to the personnel.

  8. A simple low-cost of liquid I-131 dispenser for routine radiopharmaceutical dispensing at nuclear medicine department, Institut Kanser Negara

    NASA Astrophysics Data System (ADS)

    Said, M. A.; Ashhar, Z. N.; Suhaimi, N. E. F.; Zainon, R.

    2016-01-01

    In routine radiopharmaceutical Iodine-131 (131I) dispensing, the amount of radiation dose received by the personnel depends on the distance between the personnel and the source, the time spent manipulating the source and the amount of shielding used to reduce the dose rate from the source. The novel iRAD-I131 dispenser using recycle 131I liquid lead pot will lead into low cost production, less maintenance and low dose received by the personnel that prepared the 131I. The new fabricated of low cost 131I dispenser was tested and the dose received by personnel were evaluated. The body of lead material is made from 2.5 cm lead shielded coated with epoxy paint to absorb the radiation dose up to 7.4 GBq of 131 I. The lead pot was supported with two stainless steel rod. The Optically Stimulated Luminescence (OSL) nanodot was used in this study to measure the dose rate at both extremities for every personnel who prepared the 131I. Each OSL nanodot was attached at the fingertip. Three different personnel (experienced between one to ten years above in preparing the radiopharmaceuticals) were participated in this study. The average equivalent dose at right and left hand were 122.694 ± 121.637 µSv/GBq and 77.281 ± 62.146 µSv/GBq respectively. This study found that the dose exposure received using iRAD-I131 was less up to seven times compared to the conventional method. The comparison of experimental data using iRAD-I131 and established radiopharmaceutical dispenser was also discussed. The innovation of 131I dispenser is highly recommended in a small radiopharmaceutical facility with limited budget. The novel iRAD-I131 enables implementation of higher output liquid dispensing with low radiation dose to the personnel.

  9. In Thyroidectomized Thyroid Cancer Patients, False-Positive I-131 Whole Body Scans Are Often Caused by Inflammation Rather Than Thyroid Cancer

    PubMed Central

    Garger, Yana Basis; Winfeld, Mathew; Friedman, Kent; Blum, Manfred

    2016-01-01

    Objective. To show that I-131 false-positive results on whole-body scans (WBSs) after thyroidectomy for thyroid cancer may be a result of inflammation unassociated with the cancer. Methods. We performed a retrospective image analysis of our database of thyroid cancer patients who underwent WBS from January 2008 to January 2012 to identify and stratify false positives. Results. A total of 564 patients underwent WBS during the study period; 96 patients were referred for 99 I-131 single-photon emission computed tomography (SPECT/CT) scans to better interpret cryptic findings. Among them, 73 scans were shown to be falsely positive; 40/73 or 54.7% of false-positive findings were a result of inflammation. Of the findings, 17 were in the head, 1 in the neck, 4 in the chest, 3 in the abdomen, and 14 in the pelvis; 1 had a knee abscess. Conclusions. In our series, inflammation caused the majority of false-positive WBSs. I-131 SPECT/CT is powerful in the differentiation of inflammation from thyroid cancer. By excluding metastatic disease, one can properly prognosticate outcome and avoid unnecessary, potentially harmful treatment of patients with thyroid cancer. PMID:26977418

  10. Long-Term Quality of Life and Pregnancy Outcomes of Differentiated Thyroid Cancer Survivors Treated by Total Thyroidectomy and I131 during Adolescence and Young Adulthood

    PubMed Central

    Metallo, Melanie; Groza, Lelia; Brunaud, Laurent; Klein, Marc; Weryha, Georges; Feigerlova, Eva

    2016-01-01

    Introduction. Differentiated thyroid cancer (DTC) is rare and confers good prognosis. Long-term health related quality of life (HRQoL) and pregnancy outcomes are not well known in subjects treated during adolescence and young adulthood. Methods. Cross-sectional analysis of HRQoL and global self-esteem, using SF-36 and ISP-25 surveys, and of pregnancy outcomes in female survivors of DTC treated by total thyroidectomy and I131 before age of 25 years. Results. Forty-five of 61 patients (74%) responded to the survey. Cumulative I131 activity was ≤3.85 GBq in 18 subjects and >3.85 GBq in 27 subjects. Mean time from diagnosis was 7.6 ± 5.2 years for the group ≤ 3.85 GBq versus 16.9 ± 11.6 years for the group > 3.85 GBq (P < 0.05). No significant alteration in long-term HRQoL and global self-esteem was observed. Thirty pregnancies after I131 were noted in patients from the group > 3.85 GBq and 10 in patients from the group ≤ 3.85 GBq. Frequency of miscarriages was of 17% (group > 3.85 GBq) and 10% (group ≤ 3.85 GBq) with 9 and 24 live births, respectively. No congenital malformations or first year mortality was noted. Conclusion. Long-term HRQoL, global self-esteem, and pregnancy outcomes are not affected in young female survivors of DTC. PMID:26977147

  11. Doses to the hand during the administration of radiolabeled antibodies containing Y-90, Tc-99m, I-131, and Lu-177

    SciTech Connect

    Barber, D.E.; Carsten, A.L.; Kaurin, D.G.L.; Baum, J.W.

    1997-02-01

    Exposure of the hands of medical personnel administering radiolabeled antibodies (RABs) was evaluated on the basis of (a) observing and photo-documenting administration techniques, and (b) experimental data on doses to thermoluminescent dosimeters (TLDs) on fingers of phantom hands holding syringes, and on syringes, with radionuclides in the syringes in each case. Actual exposure data for I-131 and Lu-177 were obtained in field studies. Variations in handling and administration techniques were identified. Dose rates measured using TLDs on the surface of loaded syringes were adjusted for differences in electronic stopping power, absorption coefficients, and attenuation between dosimeters and tissue to estimate dose-to-skin averaged over 1 cm{sup 2} at 7 mg cm{sup {minus}2} depth for Y-90, Tc-99m, I-131, and Lu-177. Dose rate coefficients to the skin, if in contact with the syringe wall, were 89, 1.9, 3.8, and 0.41 {micro}Sv s{sup {minus}1} per 37 MBq (1 mCi) for Y-90, Tc-99m, I-131, and Lu-177, respectively. For dose reduction, when using Y-90 the importance was clearly indicated of (a) avoiding direct contact with syringes containing RABs, if practical, and (b) using a beta-particle shield on the syringe. In using a syringe for injection, doses can best be approximated for the geometry studied by (a) wearing a finger dosimeter on the middle finger, toward the outside of the hand, on the hand operating the plunger, and (b) wearing finger dosimeters on the inner (palm) side of the finger on the hand that supports the syringe for energetic beta-particle emitters, such as Y-90 and Re-188.

  12. Utility of SPECT/CT as an adjunct to planar whole body I-131 imaging: liver metastasis from papillary thyroid cancer.

    PubMed

    Agriantonis, Demetrios J; Hall, Lance; Wilson, Michael A

    2009-04-01

    One of the major limitations of planar I-131 imaging is its lack of anatomic precision. SPECT/CT offers the benefit of precise anatomic localization that planar imaging lacks. Whether for confirmation of physiologic uptake or true pathology, SPECT/CT has an important role to play in clarifying equivocal findings. We present a case of papillary thyroid cancer metastatic to the liver, a relatively rare scenario. SPECT/CT allowed definitive lesion characterization at the time of the patient's visit to the nuclear medicine department.

  13. The standardization methods of radioactive sources (125I, 131I, 99mTc, and 18F) for calibrating nuclear medicine equipment in Indonesia

    NASA Astrophysics Data System (ADS)

    Wurdiyanto, G.; Candra, H.

    2016-03-01

    The standardization of radioactive sources (125I, 131I, 99mTc and 18F) to calibrate the nuclear medicine equipment had been carried out in PTKMR-BATAN. This is necessary because the radioactive sources used in the field of nuclear medicine has a very short half-life in other that to obtain a quality measurement results require special treatment. Besides that, the use of nuclear medicine techniques in Indonesia develop rapidly. All the radioactive sources were prepared by gravimetric methods. Standardization of 125I has been carried out by photon- photon coincidence methods, while the others have been carried out by gamma spectrometry methods. The standar sources are used to calibrate a Capintec CRC-7BT radionuclide calibrator. The results shows that calibration factor for Capintec CRC-7BT dose calibrator is 1,03; 1,02; 1,06; and 1,04 for 125I, 131I, 99mTc and 18F respectively, by about 5 to 6% of the expanded uncertainties.

  14. Effects of bone marrow cell transplant on thyroid function in an I131-induced low T4 and elevated TSH rat model

    PubMed Central

    Guajardo-Salinas, Gustavo E; Carvajal, Juan A; Gaytan-Ramos, Ángel A; Arroyo, Luis; López-Reyes, Alberto G; Islas, José F; Cano, Beiman G; Arroyo-Currás, Netzahualcoyótl; Dávalos, Alfredo; Madrid, Gloria; Moreno-Cuevas, Jorge E

    2007-01-01

    Background We developed a study using low dose radioactive iodine creating an animal model of transient elevation of thyroid stimulating hormone (TSH). Male derived bone marrow cells were transplanted to asses their effect on thyroid function and their capability to repair the thyroid parenchyma. Results At 40 an 80 days after I131 treatment, the study groups TSH and T4 serum values both increased and decreased significantly respectively compared to the negative control group. Eight weeks after cell transplantation, neither TSH nor T4 showed a significant difference in any group. The mean number of SRY gene copies found in group I (Left Intracardiac Transplant) was 523.3 and those in group II (Intrathyroid Transplant) were only 73. Group III (No Transplant) and IV had no copies. Group I presented a partial restore of the histological pattern of rat thyroid with approximately 20% – 30% of normal-sized follicles. Group II did not show any histological differences compared to group III (Positive control). Conclusion Both a significant increase of TSH and decrease of T4 can be induced as early as day 40 after a low dose of I131 in rats. Restore of normal thyroid function can be spontaneously achieved after using a low dose RAI in a rat model. The use of BM derived cells did not affect the re-establishment of thyroid function and might help restore the normal architecture after treatment with RAI. PMID:17233913

  15. Alerta De Insecto-Escarabajo asiatico de antenoas largas

    Treesearch

    Marco A. Fonseca; Ronald F. Billings

    Hay probablemente una sola generacion de ALB por a'o. Los escarabajos adultos por lo general estan presentes de mayo a octubre, pero se pueden encontrar mas temprano en la primavera o mas tarde en el oto?o si las temperaturas son calidas. Los adultos por lo general permanecen en el arbol del que emergieron o se pueden desplazar por distancias cortas hacia un...

  16. Seasonal Temperature Variations controlling Cave Ventilation Processes in Cueva Larga, Puerto Rico

    NASA Astrophysics Data System (ADS)

    Winter, A.; Vieten, R.; Warken, S. F.; Schrӧder-Ritzrau, A.; Miller, T. E.; Scholz, D.

    2016-12-01

    Two years of monthly monitoring result in much better understanding of ventilation processes in caves. Cueva Larga, a tropical cave in Puerto Rico is 1440 m long with a large main passage (about 116,000 m3). Cave air pCO2 in the main passage varied seasonally, between 600 ppm in winter and 1800 ppm in summer. The seasonal variability in cave pCO2 made it possible to estimate a cave air exchange time of 36±5 days and a winter ventilation rate of 3,200±800 m3/day for the main cave passage. Calculations of virtual temperature and differences between cave and surface temperature show that the seasonal temperature cycle is the main driver of the alternation between a well-ventilated winter mode and a near-stagnant summer mode. The winter mode is characterized by a positive buoyancy contrast at night leading to maximal cave ventilation, while during summer ventilation is at a minimum. Between winter and summer, a transitional mode of partial cave ventilation is observed. On shorter time scales (diurnal to weekly), cave pCO2 is also influenced by atmospheric pressure but this variation is one order of magnitude lower than the seasonal pCO2 change. The cave morphology of Cueva Larga including its large volume, tubular shape and the obstructed cave entrance geometry are important boundary conditions for the observed ventilation patterns. Our findings emphasize that cave systems with varying morphology have to be studied individually in order to correctly describe ventilation processes.

  17. Organ S values and effective doses for family members exposed to adult patients following I-131 treatment: A Monte Carlo simulation study

    SciTech Connect

    Han, Eun Young; Lee, Choonsik; Mcguire, Lynn; Brown, Tracy L. Y.; Bolch, Wesley E.

    2013-08-15

    Purpose: To calculate organ S values (mGy/Bq-s) and effective doses per time-integrated activity (mSv/Bq-s) for pediatric and adult family members exposed to an adult male or female patient treated with I-131 using a series of hybrid computational phantoms coupled with a Monte Carlo radiation transport technique.Methods: A series of pediatric and adult hybrid computational phantoms were employed in the study. Three different exposure scenarios were considered: (1) standing face-to-face exposures between an adult patient and pediatric or adult family phantoms at five different separation distances; (2) an adult female patient holding her newborn child, and (3) a 1-yr-old child standing on the lap of an adult female patient. For the adult patient model, two different thyroid-related diseases were considered: hyperthyroidism and differentiated thyroid cancer (DTC) with corresponding internal distributions of {sup 131}I. A general purpose Monte Carlo code, MCNPX v2.7, was used to perform the Monte Carlo radiation transport.Results: The S values show a strong dependency on age and organ location within the family phantoms at short distances. The S values and effective dose per time-integrated activity from the adult female patient phantom are relatively high at shorter distances and to younger family phantoms. At a distance of 1 m, effective doses per time-integrated activity are lower than those values based on the NRC (Nuclear Regulatory Commission) by a factor of 2 for both adult male and female patient phantoms. The S values to target organs from the hyperthyroid-patient source distribution strongly depend on the height of the exposed family phantom, so that their values rapidly decrease with decreasing height of the family phantom. Active marrow of the 10-yr-old phantom shows the highest S values among family phantoms for the DTC-patient source distribution. In the exposure scenario of mother and baby, S values and effective doses per time-integrated activity to

  18. Allogeneic hematopoietic cell transplantation after conditioning with I-131-anti-CD45 antibody plus fludarabine and low-dose total body irradiation for elderly patients with advanced acute myeloid leukemia or high-risk myelodysplastic syndrome.

    SciTech Connect

    Pagel, John M.; Gooley, T. A.; Rajendran, Joseph G.; Fisher, Darrell R.; Wilson, Wendy A.; Sandmaier, B. M.; Matthews, D. C.; Deeg, H. Joachim; Gopal, Ajay K.; Martin, P. J.; Storb, R.; Press, Oliver W.; Appelbaum, Frederick R.

    2009-12-24

    We conducted a study to estimate the maximum tolerated dose (MTD) of I-131-anti-CD45 antibody (Ab; BC8) that can be combined with a standard reduced-intensity conditioning regimen before allogeneic hematopoietic cell transplantation. Fifty-eight patients older than 50 years with advanced acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) were treated with (131)I-BC8 Ab and fludarabine plus 2 Gy total body irradiation. Eighty-six percent of patients had AML or MDS with greater than 5% marrow blasts at the time of transplantation. Treatment produced a complete remission in all patients, and all had 100% donor-derived CD3(+) and CD33(+) cells in the blood by day 28 after the transplantation. The MTD of I-131-BC8 Ab delivered to liver was estimated to be 24 Gy. Seven patients (12%) died of nonrelapse causes by day 100. The estimated probability of recurrent malignancy at 1 year is 40%, and the 1-year survival estimate is 41%. These results show that CD45-targeted radiotherapy can be safely combined with a reduced-intensity conditioning regimen to yield encouraging overall survival for older, high-risk patients with AML or MDS. This study was registered at www.clinicaltrials.gov as #NCT00008177.

  19. [Community structure of bivalves and gastropods in roots of red mangrove Rhizophora mangle (Rhizophoraceae) in isla Larga, Mochima Bay, Venezuela].

    PubMed

    Acosta Balbas, Vanessa; Betancourt Tineo, Rafael; Prieto Arcas, Antulio

    2014-06-01

    The Rhizophora mangle roots form a complex ecosystem where a wide range of organisms are permanently established, reproduce, and find refuge. In this study, we assessed the diversity of bivalves and gastropods that inhabit red mangrove roots, in isla Larga, Mochima, Venezuela Sucre state. Bimonthly collections were made from January 2007 to May 2008, in four study areas denominated: South, North, East and West. In each area, five mangrove roots were sampled, and the specimens were obtained. We analyzed a total of 180 roots and a total of 35 bivalve species and 25 gastropod species were found. The most abundant bivalves were: Isognomon alatus, Isognomon bicolor, Ostrea equestris, Crassostrea rhizophorae and Brachidontes exustus; among gastropods, the most common where: Littorina angulifera, (Cymatium pileare and Diodora cayenensis. The months with the highest abundances and number of individuals for both groups were January and July 2007, and March 2008. The mangrove ecosystem in isla Larga, presented a number of individuals and species higher than those reported for other regions in Venezuela and the Caribbean.

  20. [Radioactivity for 137Cs, 125I, 131I, 59Fe, y 57Co windows from foods included in the basic alimentary basket and in the water, consumed in the state of Carabobo, Venezuela].

    PubMed

    Torres, Annabell; Tovar, María; Malpica, Oscar; Eblen-Zajjur, Antonio

    2002-01-01

    One of the input ways of radionucleids into the organism is through food intake. The aim of the present study is to measure the radioactivity levels in food and water samples within energy windows corresponding to 137Cs, 125I, 131I, 59Fe, and 57Co. Samples were taken from local and imported food belonging to the venezuelan basic alimentary basket and included: beef meat, hen egg, chicken bone, tomato, black bean, rice, powder milk from local dealers or imported from Italy and New Zeeland, potable water from the Valencia city aqueduct and bottled water from local sources or imported from Portugal. Radioactivity was measured with a well type Nal (TI) scintillation counter. Analyzed foods and water presented levels lower than the minimal detectable activity for 137Cs, 131I, 59Fe, 57Co, but it was detected in the Valencia city aqueduct water and in bottled water imported from Portugal, levels greater than the minimal detectable activity for the 125I energy window. These results strongly suggest the need of repeated multienergy windows monitoring of radioactivity of basic alimentary basket foods and potable water.

  1. Radioactive Iodine (I-131) Therapy for Hyperthyroidism

    MedlinePlus

    ... of your treatment team. top of page What equipment is used? There is no equipment used during ... iodine therapy. top of page Who operates the equipment? There is no equipment used during radioactive iodine ...

  2. Paleoenvironmental reconstruction of the early Neolithic to middle Bronze Age Peña Larga rock shelter (Álava, Spain) from the small mammal record

    NASA Astrophysics Data System (ADS)

    Rofes, Juan; Zuluaga, Mari Cruz; Murelaga, Xabier; Fernández-Eraso, Javier; Bailon, Salvador; Iriarte, María José; Ortega, Luis Ángel; Alonso-Olazabal, Ainhoa

    2013-03-01

    The Peña Larga site, a rock shelter on the southern slopes of the Cantabrian cordillera (north Spain), is an archeological deposit covering nearly 4000 years, from the early Neolithic to the middle Bronze Age (Atlantic/Subboreal chronozones). It was used both as a household and as a stable, with a hiatus in the Chalcolithic when it was used as a collective sepulcher. Nearly twenty-eight thousand small vertebrate elements were recovered from its seven stratigraphic units, of which 2553 items were identified to the genus and/or species levels. The assemblage is composed of mammals, birds, reptiles, and amphibians. Of these, small mammals were used for paleoenvironmental reconstruction since they are very sensitive to climatic conditions, the sample sizes are large, and their preservation is good. Their distributions over time, measured in terms of relative abundance, serve as reliable proxies of habitat and climate change. The reconstruction of Peña Larga's past environments based on small mammals roughly coincides with the pollen and the amphibian/reptile records on the local scale, and with that of an ice core from Central Greenland on the global scale. This makes it a valuable tool for comparative purposes both in the regional and continental scales.

  3. Benthic foraminiferal biostratigraphy of the Aalenian-Bajocian (Middle Jurassic) boundary in the Barranco de Agua Larga section (Betic Cordillera, southern Spain)

    NASA Astrophysics Data System (ADS)

    Silva, Sílvia; Canales, María Luisa; Sandoval, José; Henriques, Maria Helena

    2016-04-01

    This work describes the benthic foraminiferal assemblages recorded across the Aalenian - Bajocian boundary in the Barranco de Agua Larga section (Betic Cordillera, SE of Spain), where the ammonite record has enabled the recognition of the Gigantea Subzone in the Bradfordensis Zone (Middle Aalenian), the Concavum and Limitatum subzones in the Concavum Zone (Upper Aalenian) and the Discites Zone (Lower Bajocian). This reference section is characterized by an alternation of limestones and marly limestones corresponding to distal marine environmental conditions, where a total of 17 samples have been collected. They have provided abundant and diverse foraminiferal assemblages, constituted by well-preserved specimens displaying close similarities to those already described for the Jurassic carbonate platforms of the Boreal Realm. From the study of the samples, a total of 3139 specimens have been obtained, corresponding to 5 suborders, 11 families, 25 genus and 80 species. The representatives of the Suborder Lagenina are the most abundant, Vaginulinidae is the most abundant family and Lenticulina is the most abundant genus. From a specific level, the most abundant species are Thurammina jurensis (Franke), Lenticulina muensteri (Roemer) and Prodentalina pseudocommunis (Franke). The occurrence of Astacolus dorbignyi (Roemer) in the Gigantea Subzone has enabled the recognition of the Astacolus dorbignyi Zone. The first occurrence of Lenticulina quenstedti (Gümbel) in the Concavum Subzone has allowed the recognition of the Lenticulina quenstedti Zone. In Barranco de Agua Larga section this species co-occur with Ramulina spandeli Paalzow, the index fossil used in the establishment of the Ramulina spandeli Zone. This zone was defined in the lower part of the Discites Zone in the Murtinheira section (the Bajocian GSSP) and related to distal platform conditions. In the Iberian Basin the Ramulina spandeli Zone was recognized in the Hontoria del Pinar section, but not in the

  4. Get the Facts About Exposure to I-131 Radiation

    MedlinePlus

    ... the U.S. government conducted about 100 nuclear weapons (atomic bomb) tests in the atmosphere at a test site ... important for Americans who grew up during the atomic bomb testing between 1945 and 1963 to be aware ...

  5. I-131 metaiodobenzylguanidine: diagnostic use in neuroblastoma patients in relapse

    SciTech Connect

    Heyman, S.; Evans, A.E.; D'Angio, G.J.

    1988-01-01

    Metaiodobenzylguanidine (MIBG) has been used for the detection and treatment of neuroectodermal tumors, including neuroblastoma. We report our experience with /sup 131/I-MIBG used diagnostically in neuroblastoma patients with relapse. Thirty-eight studies were performed in 26 patients. There were 24 children (range 3 months-14 years) and two adults. While the study was found to be both sensitive and specific for the presence of disease, there are instances of discordance. False-negative studies were found with a markedly anaplastic tumor and with two mature ganglioneuromas. A bone lesion was negative with /sup 131/I-MIBG, but positive on bone scan. A biopsy confirmed the presence of neuroblastoma. Caution should be exercised when scanning pretreated patients, and perhaps with newly diagnosed patients as well.

  6. Treatment of advanced neuroblastoma with I-131 meta-iodobenzylguanidine

    SciTech Connect

    Garaventa, A.; Guerra, P.; Arrighini, A.; Bertolazzi, L.; Bestagno, M.; De Bernardi, B.; Lanino, E.; Villavecchia, G.P.; Claudiani, F. )

    1991-02-15

    From February 1986 to December 1988, 31 children with advanced pretreated neuroblastoma were treated with 131-I meta-Iodobenzylguanidine (131-MIBG). Thirteen children had been resistant to first-line therapy, three had suffered a local relapse, and fourteen had suffered a disseminated relapse without over bone marrow infiltration. One child was treated initially because of resistance to first-line therapy, and subsequently for a local relapse. A total of 72 courses of 131-MIBG was administered, with doses ranging from 2.8 to 6.0 GBq (median, 3.7 GBq). One child received five courses, two four courses, 13 three courses, four two courses, and 12 one course of 131-MIBG. The most common toxic effect was thrombocytopenia, with a platelet level of less than 50,000/cmm occurring after 19 of 60 evaluable courses. A leukocyte count less than 1000/cmm was seen only once. There were six major responses (two complete) lasting 4 to 9 months, and two minor responses lasting longer than 38 and 44 months. Responses were seen more commonly in children whose only lesion was a residual primary tumor and in children who had not been pretreated who experienced disseminated relapse. Further studies of the role of 131-I meta-Iodobenzylguanidine in treatment of neuroblastoma are needed.

  7. Iodine Symporter Targeting with (124)I/(131)I Theranostics.

    PubMed

    Nagarajah, James; Janssen, Marcel; Hetkamp, Philipp; Jentzen, Walter

    2017-09-01

    Theranostics, a modern approach combining therapeutics and diagnostics, is among the most promising concepts in nuclear medicine for optimizing and individualizing treatments for many cancer entities. Theranostics has been used in clinical routines in nuclear medicine for more than 60 y-as (131)I for diagnostic and therapeutic purposes in thyroid diseases. In this minireview, we provide a survey of the use of 2 different radioiodine isotopes for targeting the sodium-iodine symporter in thyroid cancer and nonthyroidal neoplasms as well as a brief summary of theranostics for neuroendocrine neoplasms and metastatic castration-refractory prostate cancer. In particular, we discuss the role of (124)I-based dosimetry in targeting of the sodium-iodine symporter and describe the clinical application of (124)I dosimetry in a patient who had radioiodine-refractory thyroid cancer and who underwent a redifferentiation treatment with the mitogen-activated extracellular signal-related kinase kinase inhibitor trametinib. © 2017 by the Society of Nuclear Medicine and Molecular Imaging.

  8. Una visita en Sud America

    NASA Astrophysics Data System (ADS)

    1982-09-01

    Oisfrute de una estadfa en el Hotel La Silla, el mejor hotel de Sud America con su tan unica atmosfera extraterrestre! Los espera su calificado personal de experimentados hoteleros, jefes de cocina, etc., ansiosos todos de satisfacer sus deseos hasta el mas mfnimo detalle. Naturalmente nuestro espacioso restaurant de tres estrellas ofrece un completo surtido de exquisitas comidas y deliciosos tragos (conocedores usualmente eligen "Oelicia Orion" 0 "Centauro Especial"). EI servicio cempleto durante 24 horas incluye nuestra ya mundialmente famosa "Cena de medianoche para los miradores de estrellas", por eso - no olvide: No pierda la oportunidad de una estadfa en EL HOTEL LA SILLA - una experiencia maravillosa!

  9. Iodine I-131 With or Without Selumetinib in Treating Patients With Recurrent or Metastatic Thyroid Cancer

    ClinicalTrials.gov

    2017-03-15

    Poorly Differentiated Thyroid Gland Carcinoma; Recurrent Thyroid Gland Carcinoma; Stage IVA Thyroid Gland Follicular Carcinoma; Stage IVA Thyroid Gland Papillary Carcinoma; Stage IVB Thyroid Gland Follicular Carcinoma; Stage IVB Thyroid Gland Papillary Carcinoma; Stage IVC Thyroid Gland Follicular Carcinoma; Stage IVC Thyroid Gland Papillary Carcinoma

  10. Unilateral adrenal hyperplasia causing primary aldosteronism: limitations of I-131 norcholesterol scanning.

    PubMed

    Mansoor, George A; Malchoff, Carl D; Arici, Melih H; Karimeddini, Mozafareddin K; Whalen, Giles F

    2002-05-01

    Primary aldosteronism is a disorder that is commonly considered in patients referred to the hypertension clinic. The ease of measuring the random aldosterone-to-renin ratio in conjunction with an elevated serum aldosterone level has led to an increased screening for this disorder. Typically, patients undergo a confirmatory test after a positive screening test. However, once primary aldosteronism is confirmed, subtype delineation is critical to decide on the optimal treatment. We report a patient with resistant hypertension and primary aldosteronism with a normal computed tomographic scan of the adrenal glands, a left-sided uptake on adrenal scintigraphy, and a right-sided lateralization of aldosterone after adrenal vein sampling. A repeat adrenal vein sampling confirmed the aldosterone lateralization to the right adrenal gland, which was then removed laparoscopically. The patient had a good clinical and biochemical response, and unilateral adrenal hyperplasia was discovered at histology. Excessive reliance on adrenal scintigraphy without adrenal vein sampling may lead to serious errors in patient management.

  11. Thyrotoxicosis due to functioning metastatic follicular thyroid carcinoma after twelve I-131 therapies.

    PubMed

    Tan, Jian; Zhang, Guizhi; Xu, Wengui; Meng, Zhaowei; Dong, Feng; Zhang, Fuhai; Jia, Qiang; Liu, Xuehui

    2009-09-01

    We present a case of functioning metastatic follicular thyroid carcinoma (FTC) causing severe thyrotoxicosis despite four years 12 iodine-131 therapies (1.461 Ci cumulatively). Initially, the patient had ostalgia and fracture in the right femur. Surgery-confirmed metastatic bone FTC and thyroidectomy-confirmed FTC. One month later, iodine-131 treatment commenced. During the follow-up, different metastatic sites showed different outcomes. Lung metastases disappeared, a thigh metastasis persisted, a new metastasis in the head occurred and pelvic metastases deteriorated into a huge mass elevating thyroglobulin and causing thyrotoxicosis within 3 months. Presurgical PET/CT also demonstrated the massiveness of the pelvic metastases. Thyrotoxicosis disappeared after surgical removal of the pelvic lesion.

  12. Gonadal damage due to radioactive iodine (I131) treatment for thyroid carcinoma.

    PubMed Central

    Ahmed, S. R.; Shalet, S. M.

    1985-01-01

    Papillary carcinoma of the thyroid is the most common type of thyroid cancer and is associated with a good prognosis. Complications of treatment with surgery and radioiodine are uncommon. We report the case of a 13 year old boy who developed testicular damage following treatment with radioactive iodine 350 mCi for a papillary carcinoma of the thyroid. Four years after radioiodine treatment there has been no suggestion of recovery of spermatogenesis. Detailed follow-up studies of similarly treated young patients are required to define the incidence of this complication and to determine its reversibility. PMID:4022871

  13. Description of and link to the I-131 dose/risk calculator

    Cancer.gov

    This calculator estimates radiation dose received by the thyroid from radionuclides in fallout from nuclear tests conducted at the Nevada Test Site (NTS) and sites outside of the United States (global fallout); estimates risk of developing thyroid cancer from that exposure; and provides an estimate of probability of causation, sometimes called assigned share (PC/AS), for individuals who have been diagnosed with thyroid cancer.

  14. 77 FR 71432 - Agency Information Collection Activities: Application for Travel Document, Form Number I-131...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-30

    ... need to travel outside of the United States based on humanitarian, employment or education reasons will... humanitarian, educational and employment reasons. (5) An estimate of the total number of respondents and...

  15. Solution-reactor-produced Mo-99 using activated carbon to remore I-131

    SciTech Connect

    Kitten, S.; Cappiello, C.

    1998-06-01

    The production of {sup 99}Mo in a solution reactor was explored. Activated charcoal was used to filter the {sup 131}I contaminant from an irradiated fuel solution. Gamma spectroscopy confirmed that the activated carbon trapped a significant amount of {sup 131}I, as well as notable amounts of {sup 133}Xe, {sup 105}Rb, and {sup 140}Ba; the carbon trapped a diminutive amount of {sup 99}Mo. The results promote the idea of solution-reactor-produced {sup 99}Mo. Solution reactors are favorable both energetically and environmentally. A solution reactor could provide enough {sup 99}Mo/{sup 99m}Te to support both the current and future radiopharmaceutical needs of the U.S.

  16. Severe hyponatremia: a comorbidity with I131 therapy in a patient with papillary thyroid cancer.

    PubMed

    Kaewput, Chalermrat; Pusuwan, Pawana

    2014-08-01

    Hyponatremia is the most common electrolyte disorder in hospitalized patients, especially in elderly patients, in which morbidity varies widely in severity. A 64-year-old Thai woman with papillary thyroid cancer who developed hypothyroid state after thyroid hormone withdrawal for preparation of 1-131 treatment, had severe hyponatremia within the day of 1-131 administration. It is possible that the combination of old age, hypothyroidism, severe nausea and vomiting, and inappropriate secretion of antidiuretic hormone (SIADH) may all have precipitated the severe hyponatremia in the presented case.

  17. Iodine I 131 and Pazopanib Hydrochloride in Treating Patients With Recurrent and/or Metastatic Thyroid Cancer Previously Treated With Iodine I 131 That Cannot Be Removed By Surgery

    ClinicalTrials.gov

    2015-11-04

    Recurrent Thyroid Cancer; Stage IVA Follicular Thyroid Cancer; Stage IVA Papillary Thyroid Cancer; Stage IVB Follicular Thyroid Cancer; Stage IVB Papillary Thyroid Cancer; Stage IVC Follicular Thyroid Cancer; Stage IVC Papillary Thyroid Cancer

  18. Tositumomab and Iodine I 131 Tositumomab in Treating Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma in First Remission

    ClinicalTrials.gov

    2015-08-04

    Lymphoid Leukemia in Remission; Stage I Chronic Lymphocytic Leukemia; Stage II Chronic Lymphocytic Leukemia; Stage III Chronic Lymphocytic Leukemia; Stage III Small Lymphocytic Lymphoma; Stage IV Chronic Lymphocytic Leukemia; Stage IV Small Lymphocytic Lymphoma

  19. 10 CFR 35.394 - Training for the oral administration of sodium iodide I-131 requiring a written directive in...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ....394 Section 35.394 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL Unsealed Byproduct Material-Written Directive Required § 35.394 Training for the oral administration of sodium iodide... include— (i) Radiation physics and instrumentation; (ii) Radiation protection; (iii) Mathematics...

  20. 10 CFR 35.392 - Training for the oral administration of sodium iodide I-131 requiring a written directive in...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... millicuries). 35.392 Section 35.392 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL Unsealed Byproduct Material-Written Directive Required § 35.392 Training for the oral administration of... requiring a written directive. The training must include— (i) Radiation physics and instrumentation; (ii...

  1. 10 CFR 35.392 - Training for the oral administration of sodium iodide I-131 requiring a written directive in...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... millicuries). 35.392 Section 35.392 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL Unsealed Byproduct Material-Written Directive Required § 35.392 Training for the oral administration of... requiring a written directive. The training must include— (i) Radiation physics and instrumentation; (ii...

  2. 10 CFR 35.392 - Training for the oral administration of sodium iodide I-131 requiring a written directive in...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... millicuries). 35.392 Section 35.392 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL Unsealed Byproduct Material-Written Directive Required § 35.392 Training for the oral administration of... requiring a written directive. The training must include— (i) Radiation physics and instrumentation; (ii...

  3. 10 CFR 35.394 - Training for the oral administration of sodium iodide I-131 requiring a written directive in...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ....394 Section 35.394 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL Unsealed Byproduct Material-Written Directive Required § 35.394 Training for the oral administration of sodium iodide... include— (i) Radiation physics and instrumentation; (ii) Radiation protection; (iii) Mathematics...

  4. 10 CFR 35.394 - Training for the oral administration of sodium iodide I-131 requiring a written directive in...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ....394 Section 35.394 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL Unsealed Byproduct Material-Written Directive Required § 35.394 Training for the oral administration of sodium iodide... include— (i) Radiation physics and instrumentation; (ii) Radiation protection; (iii) Mathematics...

  5. 10 CFR 35.392 - Training for the oral administration of sodium iodide I-131 requiring a written directive in...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... millicuries). 35.392 Section 35.392 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL Unsealed Byproduct Material-Written Directive Required § 35.392 Training for the oral administration of... requiring a written directive. The training must include— (i) Radiation physics and instrumentation; (ii...

  6. 10 CFR 35.394 - Training for the oral administration of sodium iodide I-131 requiring a written directive in...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ....394 Section 35.394 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL Unsealed Byproduct Material-Written Directive Required § 35.394 Training for the oral administration of sodium iodide... include— (i) Radiation physics and instrumentation; (ii) Radiation protection; (iii) Mathematics...

  7. Decitabine in Treating Patients With Metastatic Papillary Thyroid Cancer or Follicular Thyroid Cancer Unresponsive to Iodine I 131

    ClinicalTrials.gov

    2014-08-20

    Recurrent Thyroid Cancer; Stage IVA Follicular Thyroid Cancer; Stage IVA Papillary Thyroid Cancer; Stage IVB Follicular Thyroid Cancer; Stage IVB Papillary Thyroid Cancer; Stage IVC Follicular Thyroid Cancer; Stage IVC Papillary Thyroid Cancer

  8. Potassium iodide (KI) to block the thyroid from exposure to I-131: current questions and answers to be discussed.

    PubMed

    Reiners, Christoph; Schneider, Rita

    2013-05-01

    Thyroid cancer in children and adolescents has to be considered as the most severe health consequence of a nuclear reactor emergency with release of radioiodine into the atmosphere. High doses of potassium iodide are effective to block radioiodine thyroid uptake and to prevent development of thyroid cancer years later. However, there are controversies concerning thyroid cancer risk induced by radioiodine exposure in adults. Further, the interaction of nutritional supply of potassium iodide and radioiodine uptake as well as the interaction of radioiodine with certain drugs has not been addressed properly in existing guidelines and recommendations. How to proceed in case of repeated release of radioiodine is an open, very important question which came up again recently during the Fukushima accident. Lastly, the side effects of iodine thyroid blocking and alternatives of this procedure have not been addressed systematically up to now in guidelines and recommendations. These questions can be answered as follows: in adults, the risk to develop thyroid cancer is negligible. In countries, where nutritional iodine deficiency is still an issue, the risk to develop thyroid cancer after a nuclear reactor emergency has to be considered higher because the thyroid takes up more radioiodine as in the replete condition. Similarly, in patients suffering from thyrotoxicosis, hypothyroidism or endemic goitre not being adequately treated radioiodine uptake is higher than in healthy people. In case of repeated or continued radioiodine release, more than one dose of potassium iodide may be necessary and be taken up to 1 week. Repeated iodine thyroid blocking obviously is not harmful. Side effects of iodine thyroid blocking should not be overestimated; there is little evidence for adverse effects in adults. Newborns and babies, however, may be more sensitive to side effects. In the rare case of iodine hypersensitivity, potassium perchlorate may be applied as an alternative to iodine for thyroid blocking.

  9. 10 CFR 35.394 - Training for the oral administration of sodium iodide I-131 requiring a written directive in...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...; and (v) Radiation biology; and (2) Has work experience, under the supervision of an authorized user... has achieved a level of competency sufficient to function independently as an authorized user...

  10. 10 CFR 35.392 - Training for the oral administration of sodium iodide I-131 requiring a written directive in...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) Chemistry of byproduct material for medical use; and (v) Radiation biology; and (2) Has work experience... has achieved a level of competency sufficient to function independently as an authorized user...

  11. Consentimiento informado: una praxis dialogica para la investigacion

    PubMed Central

    Mondragon-Barrios, Liliana

    2009-01-01

    El consentimiento informado es un proceso, en el que una persona acepta participar en una investigation, conociendo los riesgos, beneficios, consecuencias o problemas que se puedan presenter durante el desarrollo de la misma. El objetivo de este trabajo es reunir las caracteristicas del proceso de consentimiento informado (PCI) pare que su discernimiento y cumplimiento posibilite el ejercicio etc° dialogico, reflexivo y responsable del investigador. Se presentan los resultados de una extensa revision de les elementos del PCI, desde sus cornponentes hasta su fundamento etico y legal, incluyendo los mites y realidades que existen sobre el formato de consentimiento informado come recurso legal de protection. El consentimiento informado no es un formato establecido que los investigadores repliquen, se trata de que la praxis del PCI sea una tarea cotidiana dentro de la investigation con seres humanos, como comunicaciOn deliberative y critica, responsable y comprometida entre dos agentes morales, investigador-investigado. PMID:19507477

  12. Una búsqueda de la identidad regional em Astrometria

    NASA Astrophysics Data System (ADS)

    Abad, C.

    2003-11-01

    La idea sobre una reunión latino-americana que congregara a las personas que desarrollan su trabajo en el área de la astrometría, se gestó a partir de una de las reuniones que el proyecto QUEST realizaba anualmente en Mérida (Venezuela). El proyecto QUEST (Quasars Equatorial Survey Team) celebraba su IV Reunión Anual, en la cual se hacía una revisón de la marcha del proyecto durante el último año. Además, se exponían los logros científicos y técnicos alcanzados hasta el momento y se planificaba el futuro del mismo para el período anual siguiente.

  13. SU-E-CAMPUS-I-03: Dosimetric Comparison of the Hypoxia Agent Iodoazomycin Arabinoside (IAZA) Labeled with the Radioisotopes I-123, I-131 and I-124

    SciTech Connect

    Jans, H-S; Stypinski, D; Mcquarrie, S; Kumar, P; Mercer, J; McEwan, S; Wiebe, L

    2014-06-15

    Purpose: To compare the radiation dose to normal organs from the radio-iodinated, hypoxia-binding radiosensitizer iodoazomycin arabinoside (IAZA) for three different isotopes of iodine. Methods: Dosimety studies with normal volunteers had been carried out with [{sup 123}I]IAZA, a drug binding selectively to hypoxic sites. Two other isotopes of iodine, {sup 131}I and {sup 124}I, offer the opportunity to use IAZA as an agent for radioisotope therapy and as an imaging tracer for Positron Emission Tomography. Radioisotope dosimetry for {sup 131}I and {sup 124}I was performed by first deriving from the [{sup 123}I]IAZA studies biological uptake and excretion data. The cumulated activities for {sup 131}I or {sup 124}I where obtained by including their half-lives when integrating the biological data and then extrapolating to infinite time points considering a) physical decay only or b) physical and biological excretion. Doses were calculated using the Medical Internal Radiation Dose (MIRD) schema (OLINDA1.1 code, Vanderbilt 2007). Results: Compared to {sup 123}I, organ doses were elevated on average by a factor 6 and 9 for {sup 131}I and {sup 124}I, respectively, if both physical decay and biological excretion were modeled. If only physical decay is considered, doses increase by a factor 18 ({sup 131}I) and 19 ({sup 124}I). Highest organ doses were observed in intestinal walls, urinary bladder and thyroid. Effective doses increased by a factor 11 and 14 for {sup 131}I and {sup 124}I, respectively, if biological and physical decay are present. Purely physical decay yields a 23-fold increase over {sup 123}I for both, {sup 131}I and {sup 124}I. Conclusion: Owing to the significant dose increase, caused by their longer half life and the approximately 10 times larger electronic dose deposited in tissue per nuclear decay, normal tissue doses of IAZA labeled with {sup 131}I and {sup 124}I need to be carefully considered when designing imaging and therapy protocols for clinical trials. Effective blocking of iodine uptake in the thyroid is essential. Alberta Innovates - Health Solutions (AIHS) and Canadian Institutes of Health Research (CIHR)

  14. Iodine I 131 Monoclonal Antibody BC8 Before Autologous Stem Cell Transplant in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma

    ClinicalTrials.gov

    2016-06-10

    Recurrent B-Cell Non-Hodgkin Lymphoma; Recurrent Hodgkin Lymphoma; Recurrent T-Cell Non-Hodgkin Lymphoma; Refractory B-Cell Non-Hodgkin Lymphoma; Refractory Hodgkin Lymphoma; Refractory T-Cell Non-Hodgkin Lymphoma

  15. Improved targeting of 5-[125I/131I]iodo-2‧-deoxyuridine to rat hepatoma by using lipiodol emulsion

    NASA Astrophysics Data System (ADS)

    Yu, Hung-Man; Yeh, Hsin-Pei; Chang, Tien-Kui; Huang, Kuang-Liang; Chuang, Kuo-Tang; Liu, Ren-Shen; Wang, Shyh-Jen; Hwang, Jeng-Jong; Chi, Kwan-Hwa; Chen, Fu-Du; Lin, Wuu-Jyh; Chen, Chin-Hsiung; Wang, Hsin-Ell

    2006-12-01

    This study aims to assess whether emulsion of [ 125/131I]IUdR and lipiodol (IUdR/LP) can improve delivery of IUdR into hepatoma. MethodsIn vitro release profile of IUdR from IUdR/LP to serum was performed. IUdR/LP was injected into N1-S1 hepatoma-bearing SD rat via hepatic artery and IUdR/normal saline (IUdR/NS) was used for comparison. Biodistribution, autoradiography, imaging and tumor DNA incorporation assay were performed. The radioactive metabolites in plasma and urine were analyzed. Radiation doses to tumor and organs were estimated. ResultsIUdR released from lipiodol into serum was fast. There were longer retention, more DNA incorporation and higher radiation dose of IUdR in the tumor by using IUdR/LP. IUdR/LP deposited deep in the hepatomas. Only free iodide was found in the plasma and urine after injection of IUdR/LP. ConclusionsHepatic artery injection of IUdR/LP emulsion could definitely enhance the tumor cell uptake and incorporation to DNA of *IUdR, prolong the tumor retention time and increase radiation dose to tumor. IUdR/LP may be an effective therapeutic agent for the treatment of hepatic tumors.

  16. The usefulness of thyroid size and TSH receptor antibody (TRAb) determinations in predicting the effectiveness of tiamazole and I-131 treatment for Graves-Basedow's disease.

    PubMed

    Bojarska-Szmygin, Anna; Janicki, Krzysztof; Pietura, Radosław; Janicka, Lucyna

    2003-01-01

    The aim of the study was to assess the usefulness of determining the thyroid size, TRAb level and their correlation as markers for predicting the effectiveness of conservative treatment in Graves-Basedow's disease. The study included 100 patients with Graves-Basedow's disease; group I treated with thiamazole, group II treated with 131I. The biggest thyroid size, x -42.09+/-13.94ml, was found in the group unsuccessfully treated with thiamazole and was statistically significant compared to that in the euthyreosis group, x -31.65+/-11.74ml (p<0.01) and controls x -14.45+/-2.37ml (p<0.001). It is noteworthy that the initial TRAb level in the group with persistent hyperthyroidism was higher (x -54.39+/-31.21 U/I) than that in the euthyreosis group (x -29.13+/-19.44 U/I) and controls (x -2.75+/-2.06 U/l), p<0.001 for both parameters. Elevated antibody levels were also found after 12 and 18 months of treatment. Moreover, in the 131 I patients, the biggest thyroid size before iodine administration was found in the group with persistent hyperthyroidism, x -56.56+/-24.19 ml. It was statistically significantly different compared to the thyroid size in the euthyreosis patients x -37.922+/-20.69 ml (p<0.001) and in the hypothyreosis patients, x -43.47+/-18.09 ml (p<0.05). Before 131I administration, the highest antibody levels were observed in the group with persistent hyperthyroidism, x -103.61+/-43.90 U/I (p<0.001) compared to euthyreosis, hypothyreosis and control groups. The significance of differences in TRAb levels in the examined groups was still observed 18 months after 131I administration. In the groups of patients treated with thyreostatics and radioactive iodine, the positive correlation between the thyroid size and TRAb level was found before as well as 12 and 18 months after the onset of treatment. 1.The TRAb levels and thyroid sizes are important parameters that should be considered in predicting the effectiveness of treatment. 2. The TRAb level correlates with the thyroid size.

  17. Sunitinib in Treating Patients With Thyroid Cancer That Did Not Respond to Iodine I 131 and Cannot Be Removed by Surgery

    ClinicalTrials.gov

    2017-03-20

    Recurrent Thyroid Gland Carcinoma; Stage III Thyroid Gland Follicular Carcinoma; Stage III Thyroid Gland Medullary Carcinoma; Stage IV Thyroid Gland Follicular Carcinoma; Stage IV Thyroid Gland Medullary Carcinoma; Stage IV Thyroid Gland Papillary Carcinoma; Stage IVA Thyroid Gland Follicular Carcinoma; Stage IVA Thyroid Gland Medullary Carcinoma; Stage IVA Thyroid Gland Papillary Carcinoma; Stage IVB Thyroid Gland Follicular Carcinoma; Stage IVB Thyroid Gland Medullary Carcinoma; Stage IVB Thyroid Gland Papillary Carcinoma; Stage IVC Thyroid Gland Follicular Carcinoma; Stage IVC Thyroid Gland Medullary Carcinoma; Stage IVC Thyroid Gland Papillary Carcinoma; Thyroid Gland Oncocytic Follicular Carcinoma

  18. Iodine I 131 Tositumomab, Etoposide and Cyclophosphamide Followed by Autologous Stem Cell Transplant in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma

    ClinicalTrials.gov

    2017-07-21

    Anaplastic Large Cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Splenic Marginal Zone Lymphoma; Waldenström Macroglobulinemia

  19. Una técnica para filtrar patrones de fringing

    NASA Astrophysics Data System (ADS)

    Ostrov, P. G.

    Se presenta una nueva técnica para filtrar los patrones de fringing producidos en los CCDs tipo RCA. El método consiste en construir un mapa con los ángulos de inclinación de las franjas en cada punto de la imagen. Este mapa es ulteriormente utilizado para alinear con el patrón de interferencia una ventana estrecha, sobre la que se aplica un filtro de mediana. Este procedimiento permite eliminar la mayor parte del ruido del patrón de fringing sin destruirlo.

  20. Entropía de la información: una herramienta útil

    NASA Astrophysics Data System (ADS)

    Cincotta, P.

    En este trabajo se presenta una muy breve introducción al concepto de Entropía de la Información y se muestran distintas aplicaciones de una misma técnica para estudiar problemas tan variados como la determinación de periodicidad en una serie de tiempo arbitraria o de estimar el grado de caoticidad de una trayectoria en un sistema dinámico de N grados de libertad.

  1. UNA virus: first report of human infection in Argentina.

    PubMed

    Diaz, Luis Adrián; Spinsanti, Lorena Ivana; Almiron, Walter Ricardo; Contigiani, Marta Silvia

    2003-01-01

    Una virus (UNAV), Togaviridae family, is widely distributed in South America, where infections have been detected in mosquitoes and vertebrate hosts (humans, birds and horses). We analyzed human sera from Córdoba inhabitants aged 44 to 89 years and using a neutralization test, we found a prevalence of UNAV antibodies of 3.8% (3/79). The low titers detected suggest past infections probably acquired in rural areas of the Province of Córdoba (central Argentina). None sera were found positive for MAYV neutralizing antibodies. This is the first report of human infections by UNAV in Argentina.

  2. Radioastronomía: Una Mirada Más Amplia

    NASA Astrophysics Data System (ADS)

    Bianchi, Viviana

    2004-12-01

    The existence of the celestial bodies is known due to the light they emit. But light is a small part of a bigger phenomenon known as electromagnetic radiation. The representation of all kinds of electromagnetic radiation as a function of its frequency is called the electromagnetic spectrum. If we only studied the visible part of the spectrum, we would ignore a great deal of information. The celestial bodies emit radiation in all the regions of the electromagnetic spectrum, with very different intensity. To capture these data, astronomers design new types of telescopes that capture radiation at different wavelengths, among them the radiotelescopes that, as the name indicates, detect radio waves. The radiotelescope can be compared to a regular radio set. A radio station sends information by means of radio waves. The radio set captures these waves by means of its antenna, processes it and reproduces the information (music, etc.) in audible form. In the field of radioastronomy, interesting observations can be carried out: radio emission from stars, nebulas, pulsars, distant galaxies and stars, radiogalaxies, the Milky Way, the Sun, Jupiter, etc. La presencia de los cuerpos celestes se conoce gracias a que emiten luz. Pero la luz constituye solo una pequeña parte de un fenómeno mucho mas amplio conocido como radiación electromagnética. La representación de todas las clases de radiación como función de su frecuencia se denomina espectro electromagnético. Si solo estudiáramos la parte visual del espectro ignoraríamos una gran cantidad de información. Los cuerpos celestes emiten radiación en todas las regiones del espectro electromagnético, aunque con muy distinta intensidad. Para captar estos datos, los astrónomos deben diseñar nuevos tipos de telescopios que puedan captar la radiación de distintas longitudes de ondas, entre ellos los radiotelescopios, qué como su nombre lo indica detectan ondas de radio. El radiotelescopio puede compararse a un aparato

  3. Una propuesta para el desarrollo de un arreglo de síntesis de apertura

    NASA Astrophysics Data System (ADS)

    Arnal, E. M.

    Los estudios llevados a cabo en la transición del hidrógeno neutro a λ~21-cm han contribuído a incrementar nuestro conocimiento acerca de las propiedades globales del medio interestelar, sea este galáctico o extragaláctico. Avances en este campo han sido provocados, a menudo, por la puesta en servicio de radiotelescopios que poseen una mayor resolución angular. Aquí se presenta una propuesta para desarrollar un nuevo instrumento, un interferómetro, que permitirá abrir nuevas líneas de investigación. Este instrumento combinará la técnica de síntesis de apertura con la de espectroscopía de correlación digital, para alcanzar una resolución angular de 1' y un campo de visión de ~1o.7.

  4. Iodine I 131 Tositumomab and Fludarabine Phosphate in Treating Older Patients Who Are Undergoing an Autologous or Syngeneic Stem Cell Transplant for Relapsed or Refractory Non-Hodgkin's Lymphoma

    ClinicalTrials.gov

    2014-08-04

    Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Splenic Marginal Zone Lymphoma; Waldenström Macroglobulinemia

  5. RISK FACTORS FOR NONREMISSION AND PROGRESSION-FREE SURVIVAL AFTER I-131 THERAPY IN PATIENTS WITH LUNG METASTASIS FROM DIFFERENTIATED THYROID CANCER: A SINGLE-INSTITUTE, RETROSPECTIVE ANALYSIS IN SOUTHERN CHINA.

    PubMed

    Chen, Pan; Feng, Hui-Juan; Ouyang, Wei; Wu, Ju-Qing; Wang, Jing; Sun, Yun-Gang; Xian, Jia-Lang; Huang, Liu-Hua

    2016-09-01

    Prognostic factors related to progression-free survival (PFS) have not received much attention in the literature regarding iodine-131 ((131)I) therapy for patients with differentiated thyroid cancer and lung metastases. We sought to explore the factors associated with PFS and nonremission in a group of patients with differentiated thyroid cancer and pulmonary metastases at initial diagnosis and to investigate the impact of (131)I therapy on pulmonary function and peripheral blood counts in the same cohort of patients. The medical records of 1,050 patients with differentiated thyroid cancer treated at the Zhujiang Hospital of Southern Medical University from January 2006 to January 2015 were retrospectively reviewed. Among them, 107 patients fulfilled the inclusion criteria. Multivariate Cox regression analysis indicated that age ≥45 years and (131)I nonavidity were independent risk factors for disease progression. Multivariate logistic regression analysis revealed that pulmonary nodule size ≥1 cm and (131)I nonavidity were the strongest risk factors predicting nonremission. Varying cumulative (131)I dosage had no association with posttreatment pulmonary function or peripheral blood cell counts. Similar to earlier studies, our results confirm that (131)I nonavidity was associated with an increased risk of disease progression and greater odds of nonremission. In addition, patients with differentiated thyroid cancer and lung metastases with pulmonary nodules ≥1 cm had a reduced likelihood of achieving remission. Furthermore, special attention is needed when monitoring patients over 45 years at a higher risk of disease progression. CI = confidence interval DTC = differentiated thyroid cancer (18)F-FDG = fluoro-18 fluorodeoxyglucose FEF = forced expiratory flow FTC = follicular thyroid cancer FVC = forced vital capacity GR = granulocytes Hb = hemoglobin HR = hazard ratio (131)I = iodine-131 LN = lymph node OR = odds ratio OS = overall survival PET/CT = positive positron emission tomography/computed tomography PFS = progression-free survival PT = partial thyroidectomy PTC = papillary thyroid cancer RAI = radioactive iodine RBC = red blood cell Tg = thyroglobulin TgAb = thyroglobulin antibody TSH = thyroid-stimulating hormone TT = total thyroidectomy WBC = white blood cells WBS = whole body scan.

  6. Iodine I 131 Monoclonal Antibody BC8, Fludarabine Phosphate, Total Body Irradiation, and Donor Stem Cell Transplant Followed by Cyclosporine and Mycophenolate Mofetil in Treating Patients With Advanced Acute Myeloid Leukemia or Myelodysplastic Syndrome

    ClinicalTrials.gov

    2017-04-13

    Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Childhood Myelodysplastic Syndromes; Chronic Myelomonocytic Leukemia; Previously Treated Myelodysplastic Syndromes; Recurrent Adult Acute Myeloid Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Refractory Anemia With Excess Blasts; Refractory Anemia With Excess Blasts in Transformation; Refractory Anemia With Ringed Sideroblasts; Refractory Cytopenia With Multilineage Dysplasia; Secondary Acute Myeloid Leukemia; Secondary Myelodysplastic Syndromes

  7. Iodine I 131 Monoclonal Antibody BC8, Fludarabine Phosphate, Cyclophosphamide, Total-Body Irradiation and Donor Bone Marrow Transplant in Treating Patients With Advanced Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or High-Risk Myelodysplastic Syndrome

    ClinicalTrials.gov

    2016-12-06

    Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome; Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Myeloid Leukemia in Remission; CD45-Positive Neoplastic Cells Present; Chronic Myelomonocytic Leukemia; Previously Treated Myelodysplastic Syndrome; Refractory Anemia With Excess Blasts; Refractory Anemia With Ring Sideroblasts; Refractory Cytopenia With Multilineage Dysplasia; Refractory Cytopenia With Multilineage Dysplasia and Ring Sideroblasts

  8. Cultivating "Una Persona Educada: A Sentipensante" (Sensing/Thinking) Vision of Education

    ERIC Educational Resources Information Center

    Rendon, Laura I.

    2011-01-01

    This essay focuses on the need to educate the new "persona educada", a dignified, honorable person with a good measure of social and personal responsibility who also possesses the habits of the mind and heart. To cultivate "una persona educada" requires a newly formed vision of education and pedagogy. Examples of three entrenched agreements that…

  9. Landscape Terms and Place Names in the Trobriand Islands--The Kaile'una Subset

    ERIC Educational Resources Information Center

    Senft, Gunter

    2008-01-01

    After a brief introduction to the topic the paper first gives an overview of Kilivila landscape terms and then presents the inventory of names for villages, wells, island points, reef-channels and gardens on Kaile'una Island, one of the Trobriand Islands in the Milne Bay Province of Papua New Guinea. The data on the meaning of the place names…

  10. Landscape Terms and Place Names in the Trobriand Islands--The Kaile'una Subset

    ERIC Educational Resources Information Center

    Senft, Gunter

    2008-01-01

    After a brief introduction to the topic the paper first gives an overview of Kilivila landscape terms and then presents the inventory of names for villages, wells, island points, reef-channels and gardens on Kaile'una Island, one of the Trobriand Islands in the Milne Bay Province of Papua New Guinea. The data on the meaning of the place names…

  11. Cultivating "Una Persona Educada: A Sentipensante" (Sensing/Thinking) Vision of Education

    ERIC Educational Resources Information Center

    Rendon, Laura I.

    2011-01-01

    This essay focuses on the need to educate the new "persona educada", a dignified, honorable person with a good measure of social and personal responsibility who also possesses the habits of the mind and heart. To cultivate "una persona educada" requires a newly formed vision of education and pedagogy. Examples of three entrenched agreements that…

  12. Batkoa apiculata (Thaxter) Humber affecting Anopheles (Diptera: Culicidae) in the municipality of Una, Southern Bahia, Brazil

    USDA-ARS?s Scientific Manuscript database

    Surveys for fungal pathogens affecting adult mosquitoes from the genus Anopheles were conducted in flooded and swamp-like natural breeding sites near residences in the center and suburbs of the city of Una as well as the nearby village of Outeiro in southern Bahia. Surveys of 54 mosquito breeding si...

  13. Encendiendo una Llama. Bilingual Gifted and Talented Program: Overview, Identification of Students, and Instructional Approaches.

    ERIC Educational Resources Information Center

    Hartford Public Schools, CT.

    Three pamphlets describe facets of "Encendiendo Una Llama," a Hartford (Connecticut) demonstration program for bilingual gifted and talented students. An overview pamphlet summarizes key aspects of the model program: identification procedures, instructional services, teacher training, parent involvement, evidence of effectiveness, implementation…

  14. Year One Evaluation of "Encendiendo Una Llama" Bilingual Gifted and Talented Program. Report 80-12.

    ERIC Educational Resources Information Center

    Barstow, Daniel; Roby, Wallace R.

    The document reports activities of "Encendiendo Una Llama," a bilingual gifted and talented program serving 60 students in grades K through 6 in a school day resource room component or in an after school program. Twelve program objectives are outlined in terms of proposed activities, proposed evaluation, actual results, and…

  15. Additional lichens and some lichenicolous fungi from the Una National Park (Bosnia and Herzegovina)

    PubMed Central

    Bilovitz, Peter O.; Türk, Roman; Mayrhofer, Helmut

    2011-01-01

    A list of 62 taxa (61 species) of lichens and 7 species of lichenicolous fungi from the Una National Park in the north-western part of Bosnia and Herzegovina is presented. The lichens Caloplaca crenulatella, Dimerella pineti, Lecanora expallens, Lopadium disciforme, Placynthiella icmalea, Toninia athallina and the lichenicolous fungi Abrothallus bertianus, A. parmeliarum, Cornutispora lichenicola, Endococcus rugulosus, and Sphaerellothecium parmeliae are new to Bosnia and Herzegovina. PMID:22102780

  16. La binaria LSS 3074 y su entorno: ?`una nueva asociación OB?

    NASA Astrophysics Data System (ADS)

    Niemela, V.; Morrell, N.; Corti, M.

    En este trabajo presentamos un nuevo análisis orbital de LSS~3074, junto con tipos espectrales y velocidades radiales de estrellas que podrían constituir con ella una nueva asociación OB. La estrella O4f LSS3074 fue descubierta como binaria espectroscópica de corto período y líneas dobles por Morrell & Niemela (1990, ASP Conf. Ser. 7, 57). Posteriormente, Haefner et~al.(1994, IBVS 3969) encontraron variaciones fotométricas, estimando una inclinación orbital entre 50o y 55o. Teniendo en cuenta la importancia de obtener valores empíricos para las masas de estrellas O tempranas, y considerando la gran dispersión existente entre los valores observados y su discrepancia con los predichos por los modelos teóricos, hemos obtenido nuevas observaciones espectroscópicas de este sistema, con el propósito de mejorar los elementos orbitales derivados en la solución preliminar. Además, como las estrellas O tempranas suelen formar parte de cúmulos y asociaciones OB, hemos llevado a cabo una investigación espectroscópica de varias estrellas tempranas que podrían estar físicamente relacionadas con LSS~3074.

  17. Solution structure and functional importance of a conserved RNA hairpin of eel LINE UnaL2

    PubMed Central

    Nomura, Yusuke; Kajikawa, Masaki; Baba, Seiki; Nakazato, Shinta; Imai, Takayuki; Sakamoto, Taiichi; Okada, Norihiro; Kawai, Gota

    2006-01-01

    The eel long interspersed element (LINE) UnaL2 and its partner short interspersed element (SINE) share a conserved 3′ tail that is critical for their retrotransposition. The predicted secondary structure of the conserved 3′ tail of UnaL2 RNA contains a stem region with a putative internal loop. Deletion of the putative internal loop region abolishes UnaL2 mobilization, indicating that this putative internal loop is required for UnaL2 retrotransposition; the exact role of the putative internal loop in retrotransposition, however, has not been elucidated. To establish a structure-based foundation on which to address the issue of the putative internal loop function in retrotransposition, we used NMR to determine the solution structure of a 36 nt RNA derived from the 3′ conserved tail of UnaL2. The region forms a compact structure containing a single bulged cytidine and a U–U mismatch. The bulge and mismatch region have conformational flexibility and molecular dynamics simulation indicate that the entire stem of the 3′ conserved tail RNA can anisotropically fluctuate at the bulge and mismatch region. Our structural and mutational analyses suggest that stem flexibility contributes to UnaL2 function and that the bulged cytidine and the U–U mismatch are required for efficient retrotransposition. PMID:17000640

  18. Pasado, presente y futuro de la epidemiología. Una perspective latinoamericana

    PubMed Central

    Morabia, Alfredo

    2015-01-01

    Este artículo intenta contestar tres preguntas. Sobre el pasado: ¿Por qué no existió una epidemiología precolombina? Sobre el presente: ¿Cuáles son los orígenes de la epidemiología moderna, incluyendo sus raíces sudamericanas? Y sobre el futuro, escogí un título surrealista para enfatizar el hecho que estoy consciente de que es siempre delicado hacer predicciones: ¿Por qué fenómenos complejos son los “objetos oscuros del deseo” epidemiológico? PMID:25124247

  19. Observaciones del disco solar y de una protuberancia quiescente en radiación ultravioleta

    NASA Astrophysics Data System (ADS)

    Cirigliano, D.; Vial, J.-C.; Rovira, M.

    Observaciones del disco solar y de una protuberancia quiescente en el rango de longitudes de onda ultravioleta fueron obtenidas con el instrumento CDS (Coronal Diagnostic Spectrograph) y SUMER (Solar Ultraviolet Measurements of emitted radiation) a bordo de la sonda SOHO. El propósito es investigar las velocidades macroscópicas de varias especies metálicas que se observan tanto en el disco solar como en el plasma de las protuberancias. Para calcular las velocidades del disco solar aplicamos una técnica mixta para modelar la distribución de estructuras en UV en el Sol quieto. Las velocidades macroscópicas en las protuberancias se calcularon a partir de los corrimientos Doppler en cada línea espectral y luego se tomaron las del disco solar como referencia. Obtuvimos valores absolutos para las velocidades macroscópicas entre 5 y 40 km/seg. También detectamos comportamientos diferentes en las velocidades de las protuberancias en el centro con respecto a los bordes.

  20. Heterochromatin heterogeneity in Hypostomus prope unae (Steindachner, 1878) (Siluriformes, Loricariidae)from Northeastern Brazil

    PubMed Central

    Bitencourt, J.A.; Affonso, P.R.A.M.; Giuliano-Caetano, L.; Dias, A.L.

    2011-01-01

    Abstract Cytogenetic analyses using C-banding and chromosomal digestion by several restriction enzymes were carried out in four populations (named A, B, C and D) of Hypostomus prope unae (Loricariidae, Hypostominae) from Contas river basin, northeastern Brazil. These populations share 2n=76 and single NORs on the second metacentric pair but exclusive karyotype forms for each locality. Populations A and B presented conspicuous terminal and interstitial heterochromatic blocks on most of acrocentric chromosomes and equivalent to NORs with differences in both position and bearing pair. Population D showed evident marks at interstitial regions and interspersed with nucleolar region while population C presented interstitial and terminal heterochromatin segments, non-coincident with NORs. The banding pattern after digestion with the endonucleases Alu I, Bam HI, Hae III and Dde I revealed a remarkable heterogeneity within heterochromatin, allowing the identification of distinctive clusters of repeated DNA in the studied populations, besides specific patterns along euchromatic regions. The analysis using restriction enzymes has proved to be highly informative, characterizing population differences and peculiarities in the genome organization of Hypostomus prope unae. PMID:24260639

  1. Desarrollo curricular, conciencia ambiental y tecnologia para estudiantes de intermedia: Una investigacion en accion

    NASA Astrophysics Data System (ADS)

    Rodriguez Ramos, Teresita

    Se llevó a cabo una investigación en acción con los propósitos de 1) documentar las relaciones de las tecnologías de la información y la comunicación en las clases de ciencias de escuela intermedia como elemento de apoyo cuando se aborda el tema ambiental y sus conceptos pertinentes, a partir de las observaciones de la investigadora, así como las entrevistas y diarios reflexivos de los estudiantes de una escuela intermedia en la zona metropolitana, y luego 2) diseñar una unidad instruccional sobre el tema ambiental que integre actividades tecnologías para el curso de ciencias de la escuela intermedia según el modelo PROCIC y las observaciones que hayan iniciado los estudiantes participantes. Finalmente, se plantearon las implicaciones educativas para el currículo del Programa de Ciencias al instrumentar este modelo de unidad mediante PROCIC, e integrado la tecnología y el tema ambiental. Los hallazgos se analizaron y se categorizaron de acuerdo con las preguntas de investigación. El hallazgo principal de la investigación aborda las cuatro relaciones centrales en las que se articula la utilización de las tecnologías y sus aplicaciones en la clase de ciencias. Estas cuatro relaciones que recogen la posición de los estudiantes son: 1) Perspectiva de los estudiantes hacia la tecnología. 2) Participación de los estudiantes en los aspectos docentes. 3) Aprendizaje estudiantil sobre el ambiente, y 4) Conciencia ambiental en relación con la vida diaria. Estas relaciones ponen de manifiesto,cómo se plantea en las implicaciones, la necesidad de más investigación en acción en la sala de clases, la importancia—como tema transversal—de la conciencia ambiental mediante la tecnología al construir conocimientos significativos dentro y fuera de la escuela, asó como, valorar la investigación y la dialogicidad en la sala de clases como actividades que obligan al reexamen de la práctica didáctica en su formas curriculares de objetivos, recursos

  2. Implementation of a General Reform Plan in the Army of the Dominican Republic (IMPLEMENTACI N DE UNA REFORMA INTEGRAL EN EL EJ RCITO DE LA REPUBLICA DOMINICANA)

    DTIC Science & Technology

    2013-06-13

    IMPLEMENTACIÓN DE UNA REFORMA INTEGRAL EN EL EJÉRCITO DE LA REPÚBLICA DOMINICANA. Una tesis presentada a la Facultad de la...PAGINA DE APROBACION DE LA TESIS Nombre del Candidato: Teniente Coronel Manuel A. Carrasco Guerrero Titulo de la Tesis : Implementación de una...Reforma Integral en el Ejército de la República Dominicana Aprobado por: , Presidente del Comité de Tesis Prisco R. Hernandez, Ph.D

  3. In para totale...una cosa da panico...sulla lingua dei giovani in Italia (In para totale...una cosa da panico...The Language of Young People in Italy).

    ERIC Educational Resources Information Center

    Marcato, Carla

    1997-01-01

    Describes and analyzes the language of young people in Italy today. Particular focus is on the expressions using "para" (e.g., "in para totale" = to be very bored or worried) and the phrase "una cosa da panico" (something terrible or its opposite something wonderful). (CFM)

  4. In para totale...una cosa da panico...sulla lingua dei giovani in Italia (In para totale...una cosa da panico...The Language of Young People in Italy).

    ERIC Educational Resources Information Center

    Marcato, Carla

    1997-01-01

    Describes and analyzes the language of young people in Italy today. Particular focus is on the expressions using "para" (e.g., "in para totale" = to be very bored or worried) and the phrase "una cosa da panico" (something terrible or its opposite something wonderful). (CFM)

  5. 1981-82 Project Evaluation for Encendiendo Una Llama: A Program for Bilingual Gifted and Talented Students.

    ERIC Educational Resources Information Center

    Roby, Wallace

    The operation of "Encendiendo Una Llama," Hartford, Connecticut's program for bilingual gifted students, was evaluated for the 1981-82 school year. A total of 173 gifted children of limited English proficiency in grades 3 through 6 were served by the program at four locations. The program, staff, objectives, and target population are…

  6. [Influence of antioxidant phenovin and immunomodulator Una de gato on free radical oxidation at parodontitis].

    PubMed

    Gogebashvili, N N; Dzhashi, L M; Datunashvili, I V; Intskirveli, N A; Kiparoidze, L I

    2009-04-01

    The aim of the research: detection of changes in free radical oxidation at treatment of parodontitis with combination of preparations - antioxidant Phenovin and immunomodulator Una de gato. Reactive compounds of nitrogen, oxygen and lipids in saliva, blood and gingival tissue of patients suffering from moderate form of parodontitis has been studied by means of the electronic paramagnetic resonance (EPR) method and spin-traps (DETC, DMPO, PBN - Sigma). In patients with parodontitis content of free NO in saliva and blood increases, while in gingival tissue - decreases. In saliva, blood and gingival tissue of patients intense EPR signals of superoxidradicals (O2(-)) and lipoperoxides (LOO(-)) has been revealed indicating intensification of processes of lipid peroxidation in oral cavity, as well as in whole organism of patient. Exaggerated synthesis of NO in saliva and blood of patient is determined by high- expression of inducible NO-synthase triggered by oxidative stress, and increased activity of neuronal NO-synthase in saliva as a result of high concentrations of metacholine and P substance intensely secreted at parodontitis. Decreased content of free NO in gingival tissue of patients with parodontitis compared to control is the result of biological degradation of nitric oxide (conversion of NO into peroxinitrite on the background of intense oxidative stress in oral cavity) and nitrosylation of mitochondrial electron transport proteins of gingival tissue (characteristic for parodontitis) with further decrease in content of free oxide, suppression of intensity of mitochondrial respiration, energogenesis, development of ischemia in oral tissue leading to further initiation of destructive processes and progression of parodontitis. Treatment with combination of preparations - Phenovin and Una de gato decreased intensity of oxidative stress in organism of patients and reduced destructive processes of tissues in oral cavity. Relative normalization of oxidative metabolism

  7. eUnaG: a new ligand-inducible fluorescent reporter to detect drug transporter activity in live cells

    PubMed Central

    Yeh, Johannes T.-H.; Nam, Kwangho; Yeh, Joshua T.-H.; Perrimon, Norbert

    2017-01-01

    The absorption, distribution, metabolism and excretion (ADME) of metabolites and toxic organic solutes are orchestrated by the ATP-binding cassette (ABC) transporters and the organic solute carrier family (SLC) proteins. A large number of ABC and SLC transpoters exist; however, only a small number have been well characterized. To facilitate the analysis of these transporters, which is important for drug safety and physiological studies, we developed a sensitive genetically encoded bilirubin (BR)-inducible fluorescence sensor (eUnaG) to detect transporter-coupled influx/efflux of organic compounds. This sensor can be used in live cells to measure transporter activity, as excretion of BR depends on ABC and SLC transporters. Applying eUnaG in functional RNAi screens, we characterize l(2)03659 as a Drosophila multidrug resistant-associated ABC transporter. PMID:28176814

  8. Una Mano Amiga: Pilot Test of a Patient Navigator Program for Southwest New Mexico.

    PubMed

    Vilchis, Hugo; Onstad, Lynn E; Benavidez, Rachel; Castillo, Rebecca; Bush, Nigel; Sanchez, Janet; O'Connell, Mary; Thompson, Beti; Moinpour, Carol M

    2017-09-27

    We conducted a pilot test of a patient navigation intervention (Una Mano Amiga) to address cancer health disparities in three rural counties in southwest New Mexico. We trained two bilingual lay health workers (promotoras) as patient navigators (PNs) to help adult cancer patients and their participating families in Grant, Luna, and Hidalgo counties "navigate" the health care system, including appropriate access to social and financial services. Our hypothesized outcome was a reduction in time from diagnosis to treatment initiation compared to the average time without PNs in each of the three counties (2000-2009). We enrolled 85 eligible patients and 43 eligible family members who had completed psychosocial and demographic forms in this PN intervention. Mean time from cancer diagnosis to treatment initiation among 41 study patients was 59.6 days across the three counties. Mean time from non-intervention comparison data was 47.1 days. In the intervention group, on a 0-10 satisfaction scale (higher = more), patient mean scores for three items ranged from 9.3 to 9.6, family members, 8.9-9.3. Caregiver stress as measured by a Caregiver Self-Assessment score ≥ 10 (highest stress = 16) decreased from 23.8% of caregivers at study entry to 14.3% at follow-up (not statistically significantly different). Although the PN intervention did not decrease time from diagnosis to treatment initiation compared to three comparison counties, positive reactions of patients and family members support further research with larger samples.

  9. Genetic relationships among Mayaro and Una viruses suggest distinct patterns of transmission.

    PubMed

    Powers, Ann M; Aguilar, Patricia V; Chandler, Laura J; Brault, Aaron C; Meakins, Tiffany A; Watts, Douglas; Russell, Kevin L; Olson, James; Vasconcelos, Pedro F C; Da Rosa, Amelia Travassos; Weaver, Scott C; Tesh, Robert B

    2006-09-01

    Mayaro and Una viruses (MAYV, UNAV) are mosquito-borne alphaviruses that may cause an acute febrile illness characterized by headache, retro-orbital pain, and rash that may progress to a severe and prolonged arthralgia. MAYV was first isolated in Trinidad in 1954, and UNAV was first identified in northern Brazil in 1959. Since then, numerous isolates of these agents have been made from humans, wild vertebrates, and mosquitoes in several countries in northern South America. Serological evidence suggests that these viruses are also present in portions of Central America. Because little is known about the natural transmission cycle of MAYV and virtually nothing is known about UNAV transmission, 63 isolates covering the known geographic and temporal ranges were used in phylogenetic analyses to aid in understanding the molecular epidemiology. Approximately 2 kb from the E1 and E2 glycoprotein genes and the complete 3' non-coding region were sequenced. Phylogenetic analyses of these sequences indicated that two distinct genotypes of MAYV exist with a distinct clade consisting exclusively of UNAV (previously designated as a subtype of MAYV). One MAYV genotype (genotype D) contains isolates from Trinidad and the northcentral portion of South America including Peru, French Guiana, Surinam, Brazil, and Bolivia. All of these isolates are highly conserved with a nucleotide divergence of < 6%. The second MAYV genotype (genotype L) contains isolates only from Brazil that are highly conserved (< 4% nucleotide divergence) but are quite distinct (15-19%) from the first genotype isolates. These analyses provide possible explanations for the natural ecology and transmission of MAYV and UNAV.

  10. Evidencia de alta concentración de masa en la región nuclear de una galaxia liner

    NASA Astrophysics Data System (ADS)

    Díaz, R.; Carranza, G.; Dottori, H.; Goldes, G.

    Usando técnicas de espectroscopía bidimensional en el telescopio de 1.54 m de Bosque Alegre, se obtuvo el campo de velocidades de la región nuclear de NGC 1672, galaxia LINER con un anillo circumnuclear de regiones HII. La curva de rotación media para los 2 kpc centrales sugiere la presencia de una gran concentración de masa (ρc~ 1011Msolar /kpc3). Este resultado es respaldado por la presencia de ciertos caracteres morfológicos detectados en imágenes obtenidas con el mencionado telescopio. Según recientes simulaciones hidrodinámicas de galaxias barreadas, estos caracteres sugieren la presencia de altas densidades en las regiones nucleares. El análisis espectrofotométrico indicaría, además, la presencia de dos componentes en la emisión nuclear, con una diferencia de velocidades de ~ 200 km/s. La velocidad circular del gas ionizado a 125 pc del centro señalaría la existencia de una masa interior de ~ 7× 108Msolar .

  11. Infection by UNA virus (Alphavirus; Togaviridae) and risk factor analysis in black howler monkeys (Alouatta caraya) from Paraguay and Argentina.

    PubMed

    Díaz, Luis Adrián; Díaz, María del Pilar; Almirón, Walter Ricardo; Contigiani, Marta Silvia

    2007-10-01

    A neutralizing antibody (NTAb) survey on UNA and Mayaro viruses in black howler monkeys (Aloutta caraya) from subtropical regions of Argentina and Paraguay was carried out. Risk factors for infection in monkeys were analyzed. No positive sera for Mayaro virus were detected. A prevalence of 73% (61/84) of NTAb against UNAV was detected with titers ranging from 20 to 1280. According to the statistical analysis performed, the monkey's age was a significant risk factor, but not the origin or sex. This is the first report of Alouatta caraya infection by UNAV and the first record of its activity in Paraguay.

  12. Una conferencia de amnesia.

    PubMed

    Haas, G J

    1995-04-01

    The World Federation of Hemophilia held its 21st international meeting in Mexico City in April 1995. The crisis in current hemophilia care in developing countries is described as pathetic. One study reveals that countries not importing blood products or concentrates from the U.S. had little or no HIV transmission to persons with hemophilia, but many people were condemned to painful joint destruction. Numerous pharmaceutical, agricultural, and other companies have been caught dumping their substandard products overseas to avoid waste. The author suggests that if the fractitioners were to increase their production rate (which they could easily do), there would be enough recombinant factor concentrates to fully supply everyone in the U.S., as well as the rest of the world, at an even lower price than the intermediate-purity concentrates. Dumping inferior medical products into developing countries is viewed as irresponsible behavior. Further, the author contends that trust in the good intentions of the pharmaceutical industry, and the ability of the Federal regulatory structure, led to the ongoing death toll that the hemophilia community is now experiencing.

  13. "Una Luna Brilla."

    ERIC Educational Resources Information Center

    Teaching Music, 2002

    2002-01-01

    Focuses on the "World's Largest Concerts" listing various songs to be sung by students. Includes teaching tips in the form of quotes from music teachers on aspects of music education, such as teaching rhythm. Includes information on how to access the songs. (CMK)

  14. Dinámica y frecuencias características de una protuberancia solar observada con los instrumentos SUMER y CDS/SOHO

    NASA Astrophysics Data System (ADS)

    Rovira, M.; Costa, A.; Bocchialini, K.

    La estructura de la protuberancia estudiada puede dividirse en cuatro regiones. A partir del análisis de las imágenes del CDS y los espectros del SUMER utilizando técnicas de multiresolución con Wavelets se obtuvieron las frecuencias y velocidades relativas de cada una de las regiones. Se observan frecuencias características del orden de los 5 min y otras de largo período. Se obtuvo una fuerte anticorrelación entre las intensidades y las velocidades Doppler. La presencia de las oscilaciones de 5 min en todas las regiones sugieren el acoplamiento entre la estructura cromosférica y la protuberancia.

  15. Regiones de formación de la línea de He II λ 1640 en una atmósfera en expansión

    NASA Astrophysics Data System (ADS)

    Venero, R.; Cidale, L.; Ringuelet, A.

    Se calculan perfiles de la línea del He II λ1640 empleando un modelo de atmósfera en expansión con una estructura cromosférica para determinar la región de formación de la línea. El problema se trata en geometría esférica, fuera de equilibrio termodinámico. La ecuación de transporte radiativo se resuelve rigurosamente en el marco de referencia del fluído para distintas leyes de velocidad, monótonamente crecientes, y diferentes leyes de temperatura. Se buscan relaciones globales entre las características del perfil y los parámetros físicos atribuídos a la atmósfera estelar, con la finalidad de definir una herramienta de diagnóstico de las propiedades del medio.

  16. Geomorphological significance of the palaeodrainage network on a karst plateau: The Una-Korana plateau, Dinaric karst, Croatia

    NASA Astrophysics Data System (ADS)

    Bočić, Neven; Pahernik, Mladen; Mihevc, Andrej

    2015-10-01

    Karst plateaus often have a complex geological and geomorphological history. It is widely accepted that their development requires a long period of karst denudation. This study reconstructs the palaeodrainage network of a karst plateau, analyses its properties and establishes its geomorphological significance. The main purpose of this research was to deepen our understanding of a key stage in the evolution of karst plateaus - the transition from a fluvial land surface to one dominated by karst surface processes. The study was conducted on a large part of the Una-Korana plateau, the largest plateau in the Dinaric karst. The majority of the plateau is made of carbonate rocks of Triassic, Jurassic and Cretaceous age that set the conditions for the development of the karst. We have reconstructed the palaeodrainage network based on 1:25,000 topographic maps with 10 m contours. The transition of the surface drainage network to the underground karst drainage network is still in progress, so, depending on the degree of karstification, the drainage network was divided into three categories: active, dry and relict. It was found that 90.5% of the pre-existing drainage network has undergone some degree of karstification. The active surface drainage network gradually shifted to a dry network, then to a relict network. The surface drainage network is gradually replaced by a dense network of dolines. Today, the flat and karstified inter-fluvial area is drained underground towards the main watercourses and these drain the entire region over the surface towards the Pannonian basin. This is the largest known karst palaeodrainage network in the Dinaric karst that has been reconstructed in this way.

  17. Anthropization on the Cerrado biome in the Brazilian Uruçuí-Una Ecological Station estimated from orbital images.

    PubMed

    Pereira, A C; Gama, V F

    2010-11-01

    In this study we analysed the dynamics of deforestation and burnings during the dry seasons from 2003 to 2008 in the Uruçuí-Una Ecological Station (UUES) and its buffer zone, located in the Cerrado biome of the southwest of Piauí, a Brazil's State, based on images from the orbital sensors CCD/CBERS-2 and TM/Landsat-5. Two dates from each of the years were interpreted and analysed: one in the middle of the dry season and one at the end. The deforested areas were expanded through the period analysed and were larger in the buffer zone, suggesting a relative protection of the UUES. New cut-offs were predictable because of the early opening of roads that would become their limits. The burning scars were larger at the end of the dry season as a consequence of the management and implementation of agricultures and pastures. In 2004 and 2007 these scars were larger probably because of the increase of dry phytomass that every three years is big enough to spread the fire originated in the anthropogenic burnings through the native vegetation. This scenario reaffirms the need for: stronger enforcement in order to stop anthropisation in the UUES and a management plan, absent for this unit so far. These proceedings are urgent also because the UUES is located in one of the most preserved regions of the Cerrado and controversially where intense anthropisation in ongoing, which stresses the lack, need and urgency of biological conservation proceedings for the Piauí's southeastern Cerrado.

  18. Tratamiento Quirúrgico de los Meningiomas del Foramen Óptico, Técnicay Resultados de una Serie de 18 Pacientes

    PubMed Central

    Goldschmidt, Ezequiel; Ajler, Pablo; Campero, Álvaro; Landriel, Federico; Sposito, Maximiliano; Carrizo, Antonio

    2014-01-01

    Introducción: los meningiomas del foramen óptico producen un rápido deterioro de la función visual aún cuando su tamaño es pequeño, por eso su diagnóstico y manejo difiere del resto de los meningiomas clinoideos. El propósito de este estudio es presentar la técnica y los resultados de nuestro manejo quirúrgico de meningiomas foraminales (MF). Pacientes y Métodos: se llevó a cabo una revisión de las historias clínicas de 47 pacientes con meningiomas primarios intraorbitarios. Se realizaron 52 cirugías en los pacientes con MF. Se empleó una craneotomía fronto-orbitaria, seguida de una descompresión extradural del canal óptico, resección del componente intraorbitario y exploración intradural del nervio óptico. Resultados: de los 12 pacientes con MF que presentaban la visión conservada, la agudeza visual fue preservada en 7 casos, mejoró en 2, y empeoró en 3. En 18 pacientes, el principal síntoma fue exoftalmos y en 35 pacientes ceguera unilateral. Ocurrieron 6 recurrencias, 2 a 10 años después de la resección quirúrgica. Cinco de ellos fueron reoperados. Se indicó radioterapia después de la recurrencia en 3 pacientes. Conclusión: el manejo de los MF continúa siendo controvertido y frecuentemente se propone un tratamiento conservador. Basados en nuestros hallazgos de frecuente extensión intracraneal, proponemos realizar una resección total o subtotal del tumor, preservando el nervio óptico en pacientes con visión prequirúrgica conservada. PMID:25165616

  19. Determinación de la orientación global SAO-Hipparcos mediante una expansión en armónicos vectoriales

    NASA Astrophysics Data System (ADS)

    Cionco, R. G.; Vucetich, H.; Orellana, R.; Arias, E. F.

    En base a las diferencias de posición y movimientos propios de 101352 estrellas con posición SAO observadas por HIPPARCOS y utilizando la naturaleza vectorial de esas diferencias, determinamos 6 parámetros de orientación global (3 de rotación y 3 de desplazamiento axial), para los sistemas de referencia asociados a los marcos mencionados, mediante una descomposición en serie de armónicos vectoriales ortogonales.

  20. Seismicity in 2010 and major earthquakes recorded and located in Costa Rica from 1983 until 2012, by the local OVSICORI-UNA seismic network

    NASA Astrophysics Data System (ADS)

    Ronnie, Q.; Segura, J.; Burgoa, B.; Jimenez, W.; McNally, K. C.

    2013-05-01

    This work is the result of the analysis of existing information in the earthquake database of the Observatorio Sismológico y Vulcanológico de Costa Rica, Universidad Nacional (OVSICORI-UNA), and seeks disclosure of basic seismological information recorded and processed in 2010. In this year there was a transition between the software used to record, store and locate earthquakes. During the first three months of 2010, we used Earthworm (http://folkworm.ceri.memphis.edu/ew-doc), SEISAN (Haskov y Ottemoller, 1999) and Hypocenter (Lienert y Haskov, 1995) to capture, store and locate the earthquakes, respectively; in April 2010, ANTELOPE (http://www.brtt.com/software.html) start to be used for recording and storing and GENLOC (Fan at al, 2006) and LOCSAT (Bratt and Bache 1988), to locate earthquakes. GENLOC was used for local events and LOCSAT for regional and distant earthquakes. The local earthquakes were located using the 1D velocity model of Quintero and Kissling (2001) and for regional and distant earthquakes IASPEI91 (Kennett and Engdahl, 1991) was used. All the events for 2010 and shown in this work were rechecked by the authors. We located 3903 earthquakes in and around Costa Rica and 746 regional and distant seismic events were recorded (see Figure 1). In this work we also give a summary of major earthquakes recorded and located by OVSICORI-UNA network between 1983 and 2012. Seismicity recorded by OVSICORI-UNA network in 2010

  1. Diseno de una Actividad de Aprendizaje Basada en la Argumentacion Dialogica en un curso Virtual de Biotecnologia y su Incidencia en el Desarrollo de Competencias Cientificas

    NASA Astrophysics Data System (ADS)

    Ortiz Benavides, Fedra Lorena

    El proposito de la investigacion fue evaluar la efectividad de una actividad de aprendizaje basado en la argumentacion dialogica en linea y su incidencia en el desarrollo de competencias cientificas. Se fundamenta en la teoria del aprendizaje socio cultural de Vigotsky (1984), los principios del diseno instruccional de la cognicion situada por Hung y Der-Thang (2001) y como estrategia se aplico la argumentacion dialogica utilizando el Modelo Argumentativo de Toulmin MAT (1984). El diseno experimental comparo dos grupos de estudiantes A y B en el curso virtual de Biotecnologia. El grupo A (experimental) desarrollo la discusion a partir de la estrategia disenada para este estudio y el grupo B (control) realizo la discusion desde las actividades tradicionales. El desarrollo de la competencia argumentativa se valoro con el instrumento de evaluacion para argumentacion dialogica en linea propuesta por Clark y Sampson (2008). La evaluacion de las competencias cientificas se realizo a partir de una postprueba. Los datos fueron analizados con pruebas estadisticas no parametricas. Los resultados de la investigacion, indicaron diferencias significativas en el nivel de la competencia argumental en el grupo experimental en comparacion al grupo control. Igualmente se demostro que existe una relacion positiva entre el nivel de desarrollo de la competencia argumentativa y el nivel de desarrollo de las competencias cientificas.

  2. Estudio de nuevos vidrios y materiales vitrocristalinos del sistema Li2O-CdO-SiO2 con posible utilidad en la industria nuclear

    NASA Astrophysics Data System (ADS)

    Rincon Lopez, Jesus M.

    La electrodialisis es una tecnica que permite concentrar disoluciones salinas obteniendose como consecuencia de esta operacion dos corrientes acuosas: una concentrada en sales y otra diluida. La posibilidad de aplicar esta tecnica al tratamiento de residuos acuosos radiactivos ha sido puesta de manifiesto y en la actualidad existen instalaciones piloto en varios paises. Se ha estudiado el comportamiento de estroncio y cesio en el proceso por ser sus isotopos estroncio-90 y cesio-137 los productos de fision de vida mas larga producidos en los reactores de potencia.

  3. Identification of Suitable Water Harvesting Zones Based on Geomorphic Resources for Drought Areas: A Case Study of Una District, Himachal Pradesh, India.

    NASA Astrophysics Data System (ADS)

    Prakasam, D. C., Jr.; Zaman, B.

    2014-12-01

    Water is one of the most vital natural resource and its availability and quality determine ecosystem productivity, both for agricultural and natural systems. Una district is one of the major potential agricultural districts in Himachal Pradesh, India. More than 70% of the population of this district is engaged in agriculture and allied sectors and major crops grown are maize, wheat, rice, sugarcane, pulses and vegetables. The region faces drought every year and about 90 per cent of the area is water stressed. This has resulted in crop loss and shortage of food and fodder. The sources of drinking water, small ponds and bowlies dry-up during summer season resulting in scarcity of drinking water. Una district receives rainfall during monsoons from June to September and also during non-monsoon period (winter). The annual average rainfall in the area is about 1040 mm with 55 average rainy days. But due to heavy surface run-off the farmers not able to cultivate the crops more than once in a year. Past research indicate that the geomorphology of the Una district might be responsible for such droughts as it controls the surface as well as ground water resources. The research proposes to develop a water stress model for Una district using the geomorphic parameters, water resource and land use land cover data of the study area. Using Survey of India topographical maps (1:50000), the geomorphic parameters are extracted. The spatial layers of these parameters i.e. drainage density, slope, relative relief, ruggedness index, surface water body's frequency are created in GIS. A time series of normalized remotely sensed data of the study area is used for land use land cover classification and analyses. Based on the results from the water stress model, the drought/water stress areas and water harvesting zones are identified and documented. The results of this research will help the general population in resolving the drinking water problem to a certain extent and also the

  4. Reconexión magnética en una región activa en decaimiento

    NASA Astrophysics Data System (ADS)

    Mandrini, C. H.; Démoulin, P.; van Driel-Gesztelyi, L.; Schmieder, B.; Bagalá, L. G.; Rovira, M. G.

    Se han obtenido observaciones desde Tierra (Hα y magnetogramas) coordinadas con el Soft X-ray Telescope (SXT), a bordo del satélite japonés Yohkoh, de una región activa bipolar en decaimiento. Estos datos constituyen la base para el estudio de un punto brillante en rayos X (PBX) y de la actividad relacionada con el mismo en distintas capas de la atmósfera solar. Las observaciones muestran que el PBX está relacionado con la aparición de un bipolo menor (~ 1020 Mx) y que su abrillantamiento continuo, así como sus aumentos de brillo esporádicos (``fulguraciones"), son el resultado de la reconexión entre el pequeño arco emergente (visto en Hα como un sistema de filamentos arqueados, SFA) y arcos mayores asociados al campo facular preexistente. Se ha extrapolado el campo magnético observado en la aproximación libre de fuerzas lineal y se ha seguido su evolución a lo largo de la vida del PBX. Se ha calculado la posición de las cuasiseparatrices (CSs) a partir del campo modelado. Las líneas de campo extrapoladas, cuyas bases fotosféricas se encuentran a ambos lados de las CSs, están de acuerdo con las estructuras cromosféricas y coronales observadas. Se ha calculado el espesor de la CD ubicada a lo largo de la polaridad negativa emergente, encontrándose que su variación está de acuerdo con la evolución de la intensidad del PBX; la CS es muy delgada durante la vida del PBX (~ 100 m), mientras que su espesor aumenta considerablemente (>= 10^4 m) cuando el PBX desaparece de las imágenes del SXT. Estos resultados señalan que el abrillantamiento y las ``fulguraciones" de este PBX se deben al proceso de reconexión en 3D que tiene lugar en las CSs.

  5. EL PROGRAMA CITI: UNA ALTERNATIVA PARA LA CAPACITACIÓN EN ÉTICA DE LA INVESTIGACIÓN EN AMÉRICA LATINA

    PubMed Central

    Litewka, Sergio; Goodman, Kenneth; Braunschweiger, y Paul

    2011-01-01

    El Programa CITI (Collaborative Institutional Training Initiative) es un curso basado en Internet y desarrollado por voluntarios, que brinda material educacional sobre protección de sujetos humanos en investigaciones biomédicas y de conducta, buenas prácticas clínicas, conducta responsable de la investigación y trato humanitario a animales de laboratorio. Es un esfuerzo conjunto del Fred Hutchinson Cancer Research Center y la Universidad de Miami. Con la colaboración de expertos locales, gran parte del contenido se ha adaptado para América Latina, se ha traducido al español y portugués y se han establecido acuerdos de colaboración con instituciones especializadas en bioética en Chile, Brasil, Costa Rica y Perú. Los autores presentan una metodología accesible para la capacitación en ética de la investigación y una justificación de su uso y difusión en América Latina PMID:21687817

  6. Evolución de estrellas enanas blancas en el contexto de una constante de gravitación G variable en el tiempo

    NASA Astrophysics Data System (ADS)

    Benvenuto, O. G.; Althaus, L. G.; Torres, D. F.

    En este trabajo se estudia por primera vez de manera autoconsistente la evolución de las estrellas enanas blancas en el caso de una constante de gravitación G variable en el tiempo. Teniendo en cuenta que: 1) las enanas blancas son en general estrellas muy viejas y 2) su fuente de energía es básicamente de origen térmico y gravitacional, estos objetos son en principio muy adecuados para analizar distintas teorías de gravitación. Los cálculos que aquí presentamos fueron realizados utilizando nuestro código de evolución estelar, el cual calcula la evolución de estrellas enanas blancas por medio del esquema iterativo de Henyey. Dicho código, basado en una descripción física muy detallada, ha sido modificado para tener en cuenta la variación del valor de G. Encontramos que un G variable (decreciente en el tiempo) modifica fuertemente la evolución de las enanas blancas, conduciendo a un rápido enfriamiento de la estrella. Nuestros resultados son comparados con recientes datos observacionales sobre la función de luminosidad de las enanas blancas.

  7. Review of antiviral and immunomodulating properties of plants of the Peruvian rainforest with a particular emphasis on Una de Gato and Sangre de Grado.

    PubMed

    Williams, J E

    2001-12-01

    Viral diseases, including emerging and chronic viruses, are an increasing worldwide health concern. As a consequence, the discovery of new antiviral agents from plants has assumed more urgency than in the past. A number of native Amazonian medicines of plant origin are known to have antimicrobial and anti-inflammatory activity, although only a few have been studied for their antiviral properties and immunomodulating effects. Those most studied include: Sangre de Grado (drago) (Croton lechleri) in the Euphorbiaceae family and Una de Gato (Uncaria tomentosa) in the Rubiaceae family. This article reviews the chemical composition, pharmacological properties, state of current research, clinical use, and potential antiviral and immunomodulating activity of these and other plants from the Peruvian Amazon.

  8. Las propiedades de las estrellas extrañas en el marco de una nueva ecuación de estado para la materia extraña

    NASA Astrophysics Data System (ADS)

    Lugones, G.; Benvenuto, O. G.

    Se estudian las propiedades generales de las estrellas constituídas por materia extraña (ME) en el marco de una nueva ecuación de estado (EOS) en la que consideramos la masa de los quarks como dependiente del número medio de bariones por unidad de volumen. Se asume esta dependencia de forma que los quarks sean livianos (pesados) a densidades altas (bajas). En esta aproximación, la EOS de la ME es similar a la predicha por el modelo de la Bolsa del MIT, pero es significativamente mas dura a bajas densidades. Esta propiedad modifica las propiedades de las estrellas extrañas en forma notable. Encontramos que, con esta nueva EOS, los objetos pueden ser más masivos que en el caso de la EOS de la bolsa del MIT y que, además, pueden presentar mayores redshifts gravitatorios en hasta un 10%. En el caso de las oscilaciones radiales de estos objetos, calculamos la relación período vs. redshift gravitacional y encontramos una expresión analítica simple para el caso de las oscilaciones de objetos de baja masa. Encontramos que, aún con hipótesis muy diferentes en cuanto a la ecuación de estado de la materia extraña, las propiedades generales de estos objetos no se ve afectada en forma fundamental, y, por lo tanto, no deberían ser muy diferentes de las aquí expuestas.

  9. Síndrome del Outlet Torácico: ¿Una Patología Siempre Quirúrgica? Análisis de una Serie de 31 Cirugías Realizadas por Vía Supraclavicular Serie clínica

    PubMed Central

    Socolovsky, Mariano; Di Masi, Gilda; Binaghi, Daniela; Campero, Álvaro; Páez, Miguel Domínguez; Dubrovsky, Alberto

    2014-01-01

    Introducción: El síndrome de outlet torácico es una compresión del plexo braquial que suscita polémica. Se clasifica en Outlet Torácico Verdadero o neurogénico (OTV) y Outlet Torácico Disputado o no neurogénico (OTD). El primero presenta síntomas motores en la mano, mientras que el segundo sólo síntomas sensitivos en el miembro superior. El objetivo de este trabajo es analizar los resultados obtenidos en una serie de 31 cirugías. Métodos: Se analizaron las cirugías de nervios efectuadas entre 2003-2012, tomando los diagnósticos de outlet torácico cuyo período de seguimiento post-operatorio mínimo fuera de 6 meses. Se buscaron los siguientes datos: edad, sexo, presencia de síntomas sensitivos y/o motores, clasificación, resultado de los estudios neurofisiológicos y de imágenes, resultado de la cirugía, complicaciones post-operatorias y recidivas. Resultados: Se incluyeron 31 cirugías realizadas en 30 pacientes, 9 OTV (8 mujeres) de 24.3 años, y 21 con OTD (18 mujeres) de 37.4 años de edad en promedio. Un 90% presentaron alteraciones neurofisiológicas preoperatorias, y 66,6% imagenológicas. En el intraoperatorio, el 100% de los OTV presentó una alteración anatómica relacionada con la sintomatología, hecho observado sólo en el 36.7% de los OTD operados. El 87,5% de los OTV mejoraron sensitivamente, mientras que 77,7% mejoraron la atrofia. Por el contrario, 45.4% de los OTD mejoraron permanentemente, 36.3% no tuvieron cambios, 13.6% mejoraron transitoriamente y 4.5% (un caso) empeoró. Las complicaciones post-operatorias fueron más frecuentes aunque transitorias en el grupo de OTV (3 casos sobre 9 operados, 33.3%) que en los OTD (3 casos sobre 22, un 13.6%). Conclusión: El OTV suele mayormente mejorar luego de la cirugía, igual que el OTD aunque en una proporción mucho menor. Estos hallazgos coinciden con otros reportes recientes de esta patología. PMID:25165614

  10. 78 FR 63226 - GlaxoSmithKline LLC; Withdrawal of Approval of the Indication for Treatment of Patients With...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-23

    ... (tositumomab and iodine I 131 tositumomab) Injection held by GlaxoSmithKline LLP, P.O. Box 5089, 1250 South... and iodine I 131 tositumomab) Injection because the postmarketing study intended to verify clinical... rituximab-na ve indication for BEXXAR (tositumomab and iodine I 131 tositumomab) Injection from the...

  11. EPA se mueve hacia la prohibición de desengrasantes en aerosol y quitamanchas para lavado en seco como una de las primeras acciones reglamentarias conforme a la ley reformada de sustancias químicas

    EPA Pesticide Factsheets

    Comunicado de prensa de EPA: EPA se mueve hacia la prohibición de desengrasantes en aerosol y quitamanchas para lavado en seco como una de las primeras acciones reglamentarias conforme a la ley reformada de sustancias químicas

  12. CONTAMINACIÓN AMBIENTAL, VARIABILIDAD CLIMÁTICA Y CAMBIO CLIMÁTICO: UNA REVISIÓN DEL IMPACTO EN LA SALUD DE LA POBLACIÓN PERUANA

    PubMed Central

    Gonzales, Gustavo F.; Zevallos, Alisson; Gonzales-Castañeda, Cynthia; Nuñez, Denisse; Gastañaga, Carmen; Cabezas, César; Naeher, Luke; Levy, Karen; Steenland, Kyle

    2015-01-01

    RESUMEN El presente artículo es una revisión sobre la contaminación del agua, el aire y el efecto del cambio climático en la salud de la población peruana. Uno de los principales contaminantes del aire es el material particulado menor de 2,5 μ (PM 2,5), en la ciudad de Lima, anualmente 2300 muertes prematuras son atribuibles a este contaminante. Otro problema es la contaminación del aire domiciliario por el uso de cocinas con combustible de biomasa, donde la exposición excesiva a PM 2,5 dentro de las casas es responsable de aproximadamente 3000 muertes prematuras anuales entre adultos, con otro número desconocido de muertes entre niños debido a infecciones respiratorias. La contaminación del agua tiene como principales causas los desagües vertidos directamente a los ríos, minerales (arsénico) de varias fuentes, y fallas de las plantas de tratamiento. En el Perú, el cambio climático puede impactar en la frecuencia y severidad del fenómeno de El Niño oscilación del sur (ENSO) que se ha asociado con un incremento en los casos de enfermedades como cólera, malaria y dengue. El cambio climático incrementa la temperatura y puede extender las áreas afectadas por enfermedades transmitidas por vectores, además de tener efecto en la disponibilidad del agua y en la contaminación del aire. En conclusión, el Perú, pasa por una transición de factores de riesgo ambientales, donde coexisten riesgos tradicionales y modernos, y persisten los problemas infecciosos y crónicos, algunos de los cuales se asocian con problemas de contaminación de agua y de aire. PMID:25418656

  13. Actitud y conocimiento sobre donación de órganos de estudiantes de medicina de una universidad pública del noreste de México.

    PubMed

    Sebastián-Ruiz, María José; Guerra-Sáenz, Elda Karina; Vargas-Yamanaka, Anna Karen; Barboza-Quintana, Oralia; Ríos-Zambudio, Antonio; García-Cabello, Ricardo; Palacios-Saucedo, Gerardo Del Carmen

    2017-01-01

    Averiguar la actitud y el conocimiento que tienen los estudiantes de medicina de una universidad pública del noreste de México sobre la donación de órganos y tejidos. Estudio prolectivo, descriptivo, observacional y transversal. Se incluyeron 3056 encuestas de 34 reactivos realizadas a estudiantes de medicina durante el periodo 2013-2015 y se eliminaron aquellas con menos del 80% de los reactivos contestados. Análisis estadístico: frecuencias absolutas, porcentajes, medias, desviación estándar y prueba de ji al cuadrado. Se consideró significativo un valor de p < 0.05. El 74% de los estudiantes donaría sus órganos y el 41% lo haría por reciprocidad; del 26% que no donaría sus órganos, el 48% no lo haría por temor a que tomen sus órganos antes de estar muerto. Un 86% estaría dispuesto a donar los órganos de algún familiar. El 64% ha comentado el tema de la donación con su familia y el 67% con amigos. El 50% no ha recibido información alguna sobre el tema. El 68% entiende el concepto de muerte encefálica. Pocos estudiantes reciben información sobre donación de órganos al llegar a la universidad; pese a ello, la mayoría tiene una actitud positiva y estarían -dispuestos a -donar. The issue of organ donation is scarcely addressed during undergraduate medical studies. To evaluate the knowledge and attitude towards organ donation of medicine students of a Northwestern Mexico public university. A prolective, descriptive, observational, and cross-sectional study. A 34 items cross-sectional survey evaluating knowledge and attitude towards organ donation in 3056 medicine students during 2013-2015. Descriptive statistics were used as absolute frequencies, percentages, mean and standard deviation, as well as the Chi-square test. A p < 0.05 was considered significant. 74% of students would donate their own organs, mainly due to reciprocity (41%). 26% of students would not donate, 48% of them because of fear that their organs could be taken before death

  14. La preparacion en ciencia de los candidatos a maestros del nivel elemental primario segun la reforma de la educacion cientifica en Puerto Rico: Una propuesta de secuencia curricular

    NASA Astrophysics Data System (ADS)

    Rodriguez Plaza, Evelyn

    El proposito de esta investigacion fue identificar los componentes de la preparacion en ciencia que deben recibir los estudiantes del Bachillerato en Artes en Educacion Elemental, Nivel Primario, de acuerdo a los documentos que dirigen la reforma de la educacion cientifica en Puerto Rico. Tambien, se identificaron los componentes de los cursos que forman parte de la preparacion en ciencia de estos estudiantes. Se compararon los componentes de la preparacion en ciencia y los componentes de los cursos para determinar congruencias y discrepancias. Con los datos recopilados se identificaron los componentes de los cursos de una secuencia curricular para la preparacion en ciencia de los candidatos a maestros del nivel elemental primario. La secuencia curricular que se propone en esta investigacion incluye cursos de contenido cientifico y de metodologia en la ensenanza de la ciencia disenados para satisfacer las necesidades de los candidatos. Se recomienda que en los procesos para el diseno, la implantacion y la evaluacion de estos cursos participen profesores de ciencia, profesores de educacion y maestros del nivel elemental primario. Todos los cursos de la secuencia curricular deben tener un enfoque constructivista. Las experiencias educativas que se incluyan en los cursos deben aspirar a desarrollar en los candidatos los atributos de la cultura cientifica y actitudes positivas hacia la ciencia y hacia la ensenanza de esta disciplina. El modelaje por parte de los profesores que ensenen los cursos de la secuencia curricular es fundamental en el desarrollo profesional de los candidatos. Se recomienda que en los cursos de contenido cientifico se estudien los conceptos y los conocimientos cientificos que forman parte del curriculo de Kindergarten a tercer grado de forma integrada y con una profundidad universitaria. Estos cursos deben tener un enfoque interdisciplinario e incluir el estudio de la naturaleza de la ciencia y un componente de laboratorio para desarrollar los

  15. Cobertura de los sistemas de pensiones y factores asociados al acceso a una pensión de jubilación en México

    PubMed Central

    Murillo-López, Sandra; Venegas-Martínez, Francisco

    2016-01-01

    Resumen Objetivos: obtener estimaciones de indicadores de cobertura de las pensiones por jubilación o retiro para la población mexicana de 65 y más años, y evaluar el impacto que tienen los sistemas de pensiones en las transiciones al retiro de los adultos en edades medias y avanzadas en México. Para ello se utilizan datos microeconómicos provenientes de la Encuesta Nacional de Salud y Envejecimiento. Mediante análisis econométrico se identifican los factores sociodemográficos, económicos, laborales e institucionales que están asociados al acceso a una pensión de jubilación, o bien, a la dependencia de otras fuentes de ingresos. Se encontró que, en México, las transiciones al retiro del mercado de trabajo en las etapas avanzadas del ciclo de vida son limitadas debido a las características eminentemente contributivas de los esquemas de pensiones, los cuales favorecen a la población con trayectorias laborales formales y más estables asociadas a: características de género, oportunidades educativas y posibilidades de inserción en el mercado laboral. PMID:27524936

  16. EXPERIENCIAS RELACIONADAS A UNA INTERVENCIÓN PARA REDUCIR EL ESTIGMA RELACIONADO AL VIH/SIDA ENTRE ESTUDIANTES DE MEDICINA EN PUERTO RICO

    PubMed Central

    Cintrón-Bou, Francheska; Varas-Díaz, Nelson; Marzán-Rodríguez, Melissa; Neilands, Torsten B.

    2016-01-01

    Existe estigma relacionado al VIH. A las personas con VIH/SIDA-PCVS se les viola sus derechos y obstaculiza su bienestar mental/físico. Profesionales de la salud-PS son fuente de apoyo primordial, sin embargo estos/as le estigmatizan. Es útil adiestrar a PS en relación al estigma social. Implantamos la intervención para reducir el estigma relacionado al VIH/SIDA con 507 estudiantes de medicina. Resultó ser una intervención efectiva, hubo reducción en los niveles de estigma a partir de nuestra intervención y diferencias significativas con el grupo control (p≤.05). Generar espacios de adiestramiento para atender el estigma relacionado al VIH/SIDA es pertinente para la psicología comunitaria porque colaboramos en la reducción de actitudes estigmatizantes que afectan adversamente la prevención de nuevas infecciones, la adherencia al tratamiento antirretroviral y la calidad de vida. PMID:27829690

  17. Follow-up study using iodine-131 metaiodobenzylguanidine imaging in a patient with neuroblastoma

    SciTech Connect

    Ikekubo, K.; Habuchi, Y.; Jeong, S.; Yamaguchi, H.; Saiki, Y.; Ito, H.; Hino, M.; Higa, T.

    1986-11-01

    A new radiopharmaceutical, I-131 metaiodobenzylguanidine (I-131 MIBG) was used to determine the location and to follow-up tumors in a 13-month-old girl with neuroblastoma. I-131 MIBG imaging revealed both a primary abdominal tumor and a distant metastatic orbital tumor. Follow-up study with I-131 MIBG imaging demonstrated significant resolution of tumors after external radiotherapy and chemotherapy. I-131 MIBG imaging is a simple, safe, and specific method of determining the location of tumors and also is clinically useful in the evaluation and management of patients with neuroblastoma.

  18. Compressione gravitazionale in una dimensione

    NASA Astrophysics Data System (ADS)

    Ruffini, Remo; Sigismondi, Costantino

    2017-05-01

    The mass to produce mini black holes should surpass the repulsive force due to Pauli exclusion principle. The compression energy on the one dimensional case is calculated. The extra-mass in the mass energy balance rises as the added mass approaches the Schwarzschild radius.

  19. TEMAS PARA UNA BIOETICA LATINOAMERICANA

    PubMed Central

    Yunta, Eduardo Rodriguez

    2009-01-01

    El presente trabajo reflexiona sobre el fundamento filosófico de la bioética como disciplina, método y movimiento desde su contexto histórico y en relación con el contexto social y cultural de la vivencia latinoamericana. PMID:20209030

  20. A'Una ("Let's Go!")

    ERIC Educational Resources Information Center

    Brescia, Bill

    The guide, intended to aid students (grades four and above) in making their bodies a good home for their spirit, provides a variety of athletic activities and traditional Indian recipes for use in the classroom or in cultural programs. Apart from running (the major American Indian means of maintaining physical fitness), instructions are given for…

  1. A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

    PubMed Central

    Bramsen, Jesper B.; Pakula, Malgorzata M.; Hansen, Thomas B.; Bus, Claus; Langkjær, Niels; Odadzic, Dalibor; Smicius, Romualdas; Wengel, Suzy L.; Chattopadhyaya, Jyoti; Engels, Joachim W.; Herdewijn, Piet; Wengel, Jesper; Kjems, Jørgen

    2010-01-01

    Small interfering RNAs (siRNAs) are now established as the preferred tool to inhibit gene function in mammalian cells yet trigger unintended gene silencing due to their inherent miRNA-like behavior. Such off-target effects are primarily mediated by the sequence-specific interaction between the siRNA seed regions (position 2–8 of either siRNA strand counting from the 5′-end) and complementary sequences in the 3′UTR of (off-) targets. It was previously shown that chemical modification of siRNAs can reduce off-targeting but only very few modifications have been tested leaving more to be identified. Here we developed a luciferase reporter-based assay suitable to monitor siRNA off-targeting in a high throughput manner using stable cell lines. We investigated the impact of chemically modifying single nucleotide positions within the siRNA seed on siRNA function and off-targeting using 10 different types of chemical modifications, three different target sequences and three siRNA concentrations. We found several differently modified siRNAs to exercise reduced off-targeting yet incorporation of the strongly destabilizing unlocked nucleic acid (UNA) modification into position 7 of the siRNA most potently reduced off-targeting for all tested sequences. Notably, such position-specific destabilization of siRNA–target interactions did not significantly reduce siRNA potency and is therefore well suited for future siRNA designs especially for applications in vivo where siRNA concentrations, expectedly, will be low. PMID:20453030

  2. Diseno de una matriz de soporte compuesta de colageno de piel de tiburon-aloe para ingenier a tisular (Design of Shark Skin Collagen-Aloe Composite Scaffold for Tissue Engineering)

    DTIC Science & Technology

    2008-01-01

    atmósfera de nitrógeno. Análisis de resistencia a la tracción Las matrices de soporte se sometieron a aná- lisis de carga-deformación mediante un sistema ...única18. La unidad estructural básica del tejido colagenoso no es la molécula sola sino una asociación ordenada de moléculas en forma de unión

  3. Salivary gland accumulation of meta-(/sup 131/I)iodobenzylguanidine

    SciTech Connect

    Nakajo, M.; Shapiro, B.; Sisson, J.C.; Swanson, D.P.; Beierwaltes, W.H.

    1984-01-01

    Intense uptake of m-(/sup 131/I)iodobenzylguanidine (I-131 MIBG) has been observed in the salivary glands of patients undergoing scintigraphy for the location of suspected pheochromocytomas. This uptake of radioativity was not due to free I-131 derived from the I-131 MIBG but rather to uptake of I-131 MIBG by sympathetic neuronal elements in the salivary glands. In keeping with this, administration of tricycle antidepressants reversibly blocked salivary uptake of I-131 MIBG. Furthermore, I-131 MIBG uptake was markedly diminished by the ipsilateral salivary glands in a patient with Horner's syndrome, and was bilaterally diminished in a patient with severe idiopathic sympathetic autonomic neuropathy. The salivary gland uptake of I-131 MIBG may provide a means for the study of sympathetic innervation of these organs, and thus for the study of generalized disorders of autonomic innervation.

  4. Learning Astronomy by Playing in a Park. (Spanish Title: Aprender AstronoMía Jugando en Una Plaza.) Aprender Astronomia Brincando em Uma Praça

    NASA Astrophysics Data System (ADS)

    Camino, Néstor

    2012-12-01

    Some public-square games are presented in this paper, considered as didactic modules to help children imagine astronomical processes, based on the concept that learning in Astronomy should be developed to strengthen the relationship of our body with three-dimensional space and time, much in the same way we experience when observing the actual sky, holding a permanent "dialogue" between the actual world and what is to be learned. The games presented (merry-go-rounds and slides) were designed to work on the astronomical concepts related to the translation of the Earth around the Sun, the phases of the Moon and gravity, and on what is perceived by an observer about those phenomena. The description of each game, their physical and astronomical foundations, and a critical comment about their didactical importance are the key parts of the paper. Finally, a recommendation is given about the role teachers should play to be essential partners in the process of learning Astronomy by means of the interaction with these games. Se presentan en este trabajo algunos juegos de plaza, considerados como módulos didácticos para imaginar procesos astronómicos, a partir de la concepción de que el aprendizaje en Astronomía debe desarrollarse fortaleciendo la relación del propio cuerpo con el espacio tridimensional y con el tiempo, tal como se vive al observar el cielo, construyendo un "diálogo" entre el mundo real y los aprendizajes a construir. Los juegos presentados (calesitas y toboganes) fueron diseñados para trabajar sobre la traslación de la Tierra en torno al Sol, las fases de la Luna y la gravedad, y sobre lo que un observador percibe de los mismos. Se da la descripción de cada juego, se discuten sus fundamentos físicos y astronómicos, y se desarrolla una crítica didáctica de los mismos. Finalmente, se comenta el rol que deberían tener los docentes en el acompañamiento a los aprendices en el proceso de interacción con los juegos presentados. Apresentam-se neste

  5. Revision curricular a partir de un analisis comparativo de las discrepancias en los curriculos de una escuela de optometria en Puerto Rico con las competencias requeridas para las agencias de revalida y acreditacion 2004

    NASA Astrophysics Data System (ADS)

    Rivera Pacheco, Andres

    El proposito de esta investigacion, un estudio cualitativo de caso, fue comparar y contrastar el curriculo vigente de la Escuela de Optometria de la UIAPR con las competencias y estandares requeridos por las agencias de acreditacion y de revalida. Con este proposito, decidimos realizar una revision y un analisis de documentos: el prontuario de cada uno de los cursos de los curriculos implantados en el 1993 y en el 2001; las competencias y estandares establecidos por las agencias de revalida y de acreditacion; y las estadisticas en las que se analiza el porcentaje de estudiantes que aprueban cada una de las partes de los examenes de revalida entre el 1998 al 2003. Se realizaron entrevistas dirigidas para dar apoyo y complementar la revision y el analisis de estos documentos. Los participantes de las entrevistas fueron tres estudiantes de la clase de optometria del 2004 (ultima clase del curriculo del 1993); tres estudiantes de la clase de optometria del 2005 (primera clase graduanda del curriculo vigente) y tres profesores y/o directores de los Departamentos de Ciencias Basicas, Ciencias Clinicas y Cuidado al Paciente. Esta investigacion se enmarco en el modelo de evaluacion curricular de discrepancia de Malcolm Provus y en el modelo de desarrollo basado en competencias. Uno de los hallazgos mas importantes del estudio es que los cambios que se implantaron al curriculo del 2001 no han logrado que los estudiantes mejoren su ejecucion en los examenes de revalida. Por otro lado, se encontro que el curriculo vigente atiende completamente los estandares de la practica de Optometria, pero no las competencias. Esta informacion fue validada mediante el uso de una tabla de cotejo para el analisis de los cursos y de la informacion obtenida de las entrevistas. El estudio determina y concluye que existen discrepancias entre los prontuarios de los cursos del curriculo y las competencias requeridas por la agencia de revalida. Segundo, que el Departamento de Ciencias Basicas es el

  6. [Value of electroencephalography in the early detection of neonatal leucinosis].

    PubMed

    Pardal-Fernandez, J M; Carrascosa-Romero, M C; Grande, A; Martinez-Gonzalez, M; Godes-Medrano, B

    2016-08-16

    Introduccion. La leucinosis es una metabolopatia neonatal grave. Es consecuencia del deficit enzimatico determinado geneticamente del complejo descarboxilasa-dihidrolipoil transacilasa y dihidrolipoil deshidrogenasa, y del acumulo consecuente de los metabolitos precursores, aminoacidos ramificados de cadena larga y sus alfa-cetoacidos. Son potentes neurotoxicos, responsables del rapido establecimiento de edema y desmielinizacion cerebral difusa. La demora en el diagnostico suele provocar graves secuelas psicomotoras o incluso la muerte. Caso clinico. Se presenta una paciente neonata con encefalopatia neonatal grave, crisis epilepticas y un electroencefalograma (EEG) con unas caracteristicas especiales que oriento el diagnostico hacia una posible leucinosis. El diagnostico temprano permitio instaurar rapidamente el tratamiento especifico y conseguir una evolucion favorable de la paciente. Conclusiones. El EEG en pacientes con sospecha de encefalopatia neonatal ofrece informacion funcional de alta rentabilidad con un bajo coste, en especial por promover diagnosticos y tratamientos tempranos. El EEG en la leucinosis presenta signos peculiares, reconocibles en periodos tempranos en la mayor parte de los afectados, como ocurrio en el caso descrito. Parece recomendable integrar el EEG en el cribado de encefalopatias neonatales por ser una tecnica diagnostica valiosa, inocua y, por lo general, accesible y especialmente de ayuda en metabolopatias tratables, como la leucinosis.

  7. Adapting a Common Photographic Camera to Take Pictures of the Sky. (Spanish Title: Adaptando Una Camara Fotografica Comun Para Obtener Fotografias del Cielo.) Adaptando Uma Câmera Fotográfica Manual Simples Para Fotografar o Céu

    NASA Astrophysics Data System (ADS)

    Danhoni Neves, Marcos Cesar; Pereira, Ricardo Francisco

    2007-12-01

    In this paper will be introduced a method of astrophotography using a non-reflex photographic camera (a low-cost method). It will be revised some photographic processes commonly used nowadays for comparison with the aims of this paper. En este trabajo será introducido un método de astrofotografia que utiliza una cámara fotográfica non-reflex (un método de bajo costo). Serán revisados algunos procesos fotográficos comúnmente utilizados actualmente para comparación con los objetivos de este trabajo. O presente artigo procura introduzir um método de astrofotografia utilizando uma câmera fotográfica não reflex, de baixo custo. É feita uma revisão do processo fotográfico comumente empregado para fins de comparação com os objetivos pretendidos no presente trabalho.

  8. In vivo efficacy and off-target effects of locked nucleic acid (LNA) and unlocked nucleic acid (UNA) modified siRNA and small internally segmented interfering RNA (sisiRNA) in mice bearing human tumor xenografts.

    PubMed

    Mook, Orf; Vreijling, Jeroen; Wengel, Suzy L; Wengel, Jesper; Zhou, Chuanzheng; Chattopadhyaya, Jyoti; Baas, Frank; Fluiter, Kees

    2010-07-01

    The clinical use of small interfering RNA (siRNA) is hampered by poor uptake by tissues and instability in circulation. In addition, off-target effects pose a significant additional problem for therapeutic use of siRNA. Chemical modifications of siRNA have been reported to increase stability and reduce off-target effects enabling possible therapeutic use of siRNA. Recently a large scale direct comparison of the impact of 21 different types of novel chemical modifications on siRNA efficiency and cell viability was published.1 It was found that several types of chemical modifications could enhance siRNA activity beyond that of an unmodified siRNA in vitro. In addition, a novel siRNA design, termed small internally segmented interfering RNA (sisiRNA), composed of an intact antisense strand and segmented guide strand stabilized using LNA was shown to be effective in cell based assays. In the present study we examined the in vivo efficacy of the LNA and UNA modified siRNA and sisiRNA in a mouse model bearing human tumor xenografts. We studied the biodistribution and efficacy of target knockdown in the mouse model. In addition we used whole genome profiling to assess the off-target effects in the liver of the mouse and the tumor xenografts. We report that LNA and UNA modified siRNA and sisiRNA improve the efficacy in target knockdown as compared with unmodified siRNA in the tumor xenografts without formulation. However, the level of off-target gene regulation in both the tumor and the liver correlated with the increase in efficacy in target knockdown, unless the seed region of the siRNA was modified.

  9. Radioiodine therapy of hyperthyroidism precludes thallium-201 myocardial scintigraphy

    SciTech Connect

    Orzel, J.A.; Kruyer, W.B.; Borchert, R.D.

    1987-02-01

    The authors attempted to perform Tl-201 myocardial perfusion scintigraphy in a 42-year-old man 23 and 35 days after he received 9.8 mCi of oral I-131 for documented Graves' disease. Interference from primary and scattered photons from residual thyroid I-131 made Tl-201 myocardial scintigraphy technically impossible. A series of phantom and patient studies using I-131 and Tl-201 were performed, yielding guidelines for planning Tl-201 myocardial scintigraphy following radioiodine therapy.

  10. General Nuclear Medicine

    MedlinePlus

    ... Children's (Pediatric) Nuclear Medicine Radioactive Iodine (I-131) Therapy Biopsies - Overview Radioimmunotherapy (RIT) Alzheimer's Disease X-ray, Interventional Radiology and Nuclear Medicine ...

  11. Diagnosis and treatment of a carcinoid tumor using iodine-131 meta-iodobenzylguanidine

    SciTech Connect

    Hoefnagel, C.A.; Den Hartog Jager, F.C.; Van Gennip, A.H.; Marcuse, H.R.; Taal, B.G.

    1986-03-01

    Scintigraphy using I-131 meta-iodobenzylguanidine has been introduced as an effective method to detect pheochromocytomas and neuroblastomas, and the radiopharmaceutical also is applied in therapy of these tumors. The authors present a case of a metastatic gastric carcinoid tumor, another neural crest tumor, concentrating I-131 MIBG, which was documented by conventional scintigraphy and SPECT in correlation with CT scans and colloid scintigrams of the liver. Two therapeutic attempts in this patient, using I-131 MIBG, are described. The metabolic basis of this phenomenon is discussed, and the importance of I-131 MIBG imaging in the detection of neural crest tumors is underlined.

  12. The Moon Phases in a Paper Box. (Spanish Title: Las Fases de la Luna en Una Caja de Cartón.) As Fases da Lua Numa Caixa de Papelão

    NASA Astrophysics Data System (ADS)

    de Fátima O. Saraiva, Maria; Amador, Cláudio B.; Kemper, Érico; Goulart, Paulo; Muller, Angela

    2007-12-01

    We present a very simple concrete model to demonstrate the concept of phases of an illuminated body. The main objective of our model is to help the understanding of the Moon phases as viewed from the perspective of an observer on Earth. The material allows the visualization of two important effects: (1st) even though all the time half Moon is illuminated by the Sun, we see different fractions of the illuminated Moon surface, depending on our angle of sight; (2nd) the orientation of the convex part of the Moon in the crescent and waning phases on the sky also depends on our perspective from Earth. The use of a closed box allows one to see the contrast among the different phases with no need of a dark room. We also present a text on the Moon phases, emphasizing the dependence of the aspect of the bright part on the angle of sight. En este trabajo proponemos la construcción de material didáctico de bajo costo para demostración del concepto de fases de un cuerpo iluminado. El principal objetivo de nuestro material es facilitar la comprensión de las fases de la Luna desde la perspectiva de un observador en la Tierra. El material ayuda la visualización de dos efectos importantes: (1º) a pesar de tener siempre la mitad de la Luna (representada por una bolita de espuma plástica o de ping-pong), iluminada por el Sol ( representado por una fuente de luz natural o artificial), vemos diferentes fracciones de su superficie iluminada, dependiendo del ángulo por el cual la vemos; (2º) la orientación del borde convexo de la Luna en las fases Creciente y Menguante también depende de la perspectiva por la cual la miramos desde la Tierra. El uso de una caja cerrada permite observar el contraste entre las diferentes fases sin necesidad de estar en un recinto oscuro. Presentamos también un texto explicativo sobre las fases de la Luna, enfatizando la dependencia de la apariencia de la parte iluminada con el ángulo de visión. Neste trabalho propomos a construção de

  13. Autoreporte de exposición a publicidad y promoción de tabaco en una cohorte de fumadores mexicanos: Antes y durante la publicación de la Ley General para el Control del tabaco en 2008

    PubMed Central

    Hernández, Rosaura Pérez; Thrasher, James F.; Bolaños, Rosibel Rodríguez; Gutiérrez, Inti Barrientos; Hernández, Norma A Ibañez

    2015-01-01

    Resumen Objetivo Determinar en población fumadora el nivel de exposición a la mercadotecnia por parte de la Industria Tabacalera (IT), a través de diferentes métodos de promocionar sus productos de tabaco, antes y durante la publicación de la Ley General para el Control del Tabaco (LGCT) en 2008. Material y métodos Estudio de cohorte en fumadores adultos (n=941 pre-LGCT y n=1051 post-LGCT) de cuatro ciudades mexicanas. Se realizaron análisis multivariados mediante modelos de ecuaciones de estimación generalizada (GEE). Resultados Se incremento el autoreporte de recepción de muestras gratis de cigarros (3.7% a 8.1%), ropa o artículos con marcas o logos (3.6% a 6.4%), haber visto información sobre eventos especiales (1.9% a 4.7%), y bares, antros y discos para mayores de edad (21.4% a 28%). Se observaron decrementos de publicidad en exteriores (54.7% a 47.2%). Conclusión Es necesaria una política integral con prohibiciones totales de la publicidad y promoción de los productos de tabaco que integre mayor vigilancia y sanciones para lograr la disminución y prevención del consumo de tabaco. PMID:22689158

  14. Unas opciones para muestras de la naturaleza

    Treesearch

    Frank H. Wadsworth

    2009-01-01

    La ciencia, incluso la de Puerto Rico, aprende de muestras, su interpretación y extrapolación a situaciones más extensas. Las muestras de la naturaleza de Puerto Rico: las del suelo, la hojarasca, la sombra, la biomasa, los árboles, las aves, los reptiles y anfibios, o los insectos caracterizan los ecosistemas. [article in Spanish

  15. Suva Una? (What Is It Doing?)

    ERIC Educational Resources Information Center

    MacLean, Edna A.

    This primary level reader is part of a series of materials developed for beginning reading instruction in Barrow Inupiaq. Each page consists of a drawing and brief text. It is a revision of an earlier version of the same title. (AMH)

  16. Ciencia, Sociedad, Soluciones: Una Introduccion al USGS

    USGS Publications Warehouse

    ,

    2001-01-01

    El USGS sirve a la nacion de los Estados Unidos proveyendo informacion fidedigna para ? Describir y comprender la Tierra; ? Minimizar la perdida de vidas y propiedades por desastres naturales; ? Manejar los recursos hidrologicos, biologicos, energeticos y minerales; y ? Mejorar y proteger nuestra calidad de vida.

  17. Basic Concepts of Astronomy: a Methodological Proposal. (Spanish Title: Conceptos Básicos de Astronomía: Una Propuesta Metodológica.) Conceitos Básicos de Astronomia: Uma Proposta Metodológica

    NASA Astrophysics Data System (ADS)

    Darroz, Luiz Marcelo; Heineck, Renato; Samudio Pérez, Carlos Ariel

    2011-12-01

    In this report, the development of a methodological proposal which approaches basic concepts of astronomy-grounded pedagogically on Meaningful Learning is described. The proposal, which consists of four meetings, was developed by teachers and academics of the course of Professor in Physics of the University of Passo Fundo (UPF), through an extension course to a group of highschool students of a public school of the town of Passo Fundo, RS. The work was focused into basic concepts of astronomy. The signs of Meaningful Learning have been obtained by means of research and evaluation tools that were applied at the end of each meeting. The evaluation of the proposal has been conducted by means of a final questionnaire which was answered by the participants at the end ofthe development of activities. By means of the results obtained from the different instruments, and the comments made by the participants during the activities and by means of the high rates of approval obtained in the final questionnaire, we think that the proposal reached the established goals and it may be repeated with the certainty of success. En este relato se describe una propuesta de desarrollo metodológico que aborda conceptos básicos de astronomía fundamentada pedagógicamente en el Aprendizaje Significativo. La propuesta que comprende cuatro encuentros, fue desarrollada por profesores y académicos del curso de Licenciatura en Física de la Universidad de Passo Fundo (UPF), a través de un curso de extensión para un grupo de Liceo del 6º año de una Escuela Pública de la ciudad de Passo Fundo/RS. El trabajo tuvo como eje principal los "conceptos básicos de astronomía". Los indicios de Aprendizaje Significativo fueron obtenidos por instrumentos de pesquisa y evaluación, siempre aplicados después de cada encuentro. La evaluación de la propuesta fue hecha a través de un cuestionario final y contestado por los participantes al finalizar el desarrollo de actividades. Por los resultados

  18. A Proposed Activity for a Meaningful Learning about the Moon Phases. (Breton Title: Uma Proposta de Atividade Para a Aprendizagem Significativa sobre as Fases da Lua.) Una Actividad Propuesta Para EL Aprendizaje Significativo Acerca de Las Fases de la Luna

    NASA Astrophysics Data System (ADS)

    Martins, Bruno Andrade; Langhi, Rodolfo

    2012-12-01

    ínua avaliação durante o processo, culmina com a elaboração de uma história em quadrinhos envolvendo as fases da Lua. Portanto, o objetivo deste trabalho é apresentar uma proposta de atividade didática diferenciada sustentada pelos princípios teóricos da aprendizagem significativa aplicada ao ensino das fases da Lua durante as aulas de Física no ensino médio. En este trabajo se presenta uno de los contenidos de la Astronomía y el evidente fracaso en la enseñanza del tema en la escuela secundaria, a pesar del hecho que los documentos oficiales apuntan para la necesidad de trabajar contenidos de Astronomía en este nivel. Entre los conceptos alternativos en Astronomía que los alumnos secundarios llevan consigo, aún después de terminados los estudios, destacamos aquí el fenómeno de las fases de la Luna. El desarrollo de diferentes estrategias en relación con los métodos tradicionales, dirigidas al proceso de enseñanza-aprendizaje en este tema fue considerado en este trabajo como uno de los resultados obtenidos a la luz de los referenciales del aprendizaje significativo, tal como fueron fundamentados por Ausubel. Según la propuesta que aquí se presenta, la participación activa de los estudiantes en la ejecución de una actividad experimental y otras actividades educativas destinadas a la evaluación continua durante el proceso culminó en la elaboración de una historieta respecto de las fases de la Luna. Por lo tanto, el objetivo de este trabajo es presentar una propuesta de actividad de enseñanza diferenciada con el apoyo de los principios teóricos del aprendizaje significativo aplicado a la enseñanza de las fases de la luna durante las clases de física del ciclo secundario.

  19. Estudio epidemiológico de sucesos traumáticos, trastorno de estrés post-traumático y otros trastornos psiquiátricos en una muestra representativa de Chile

    PubMed Central

    Pérez Benítez, Carlos I.; Vicente, Benjamin; Zlotnick, Caron; Kohn, Robert; Johnson, Jennifer; Valdivia, Sandra; Rioseco, Pedro

    2010-01-01

    RESUMEN Durante la década de 1990 en los Estados Unidos (EU), el conocimiento sobre el trastorno de estrés post-traumático (TEPT) evolucionó de estudios específicos en un principio, sobre veteranos de guerra y sobre víctimas de desastres, a estudios epidemiológicos más tarde, sin embargo, la epidemiología del TEPT en países en desarrollo ha sido un área poco estudiada hasta ahora. Los expertos en el área de trauma han propuesto que los sucesos traumáticos que ocurren en la niñez son más perjudiciales para la salud mental que aquellos que ocurren más tarde en la vida. Este trabajo revisa los resultados de un estudio epidemiológico llevado a cabo en Chile. Específicamente, se revisan los resultados sobre las tasas de prevalencia del TEPT, traumas asociados más frecuentemente con él, así como la comorbilidad de este trastorno con otros trastornos psiquiátricos a lo largo de la vida. Igualmente se analizaron las diferencias del TEPT en cada sexo, así como la exposición a traumas en una muestra representativa de chilenos. Además se comparó la prevalencia de trastornos psiquiátricos en personas que sufrieron su primer trauma durante la niñez, durante la edad adulta, o que no reportaron traumas durante su vida. En estos estudios epidemiológicos se usaron módulos del TEPT y trastorno de personalidad antisocial (TPA) de la entrevista diagnóstica siguiendo los criterios del DSM-III-R (DIS–III-R). Para evaluar el resto de los trastornos psiquiátricos se usó la Entrevista Diagnóstica Internacional Compuesta (CIDI). Estos instrumentos fueron administrados en tres ciudades chilenas a 2390 personas mayores de 15 años. Para estimar los errores estándares (EE) debido al diseño de la muestra y a la necesidad de ajuste se usó el método Taylor de linearización seriada. También se usó un análisis de regresión logística para examinar la relación entre el TEPT, los factores demográficos de riesgo y el tipo de trauma. Además se utilizó la

  20. Short-Term Side Effects after Radioiodine Treatment in Patients with Differentiated Thyroid Cancer.

    PubMed

    Lu, Liyan; Shan, Fengling; Li, Wenbin; Lu, Hankui

    2016-01-01

    I-131 therapy for differentiated thyroid cancer (DTC) could induce adverse effects. The purpose of this study was to report and analyze symptoms after I-131 treatment within the hospitalization and present relevant medical intervention. I-131 doses ranging from 3.7 to 9.25 GBq (100-250 mCi) were administrated for thyroid remnant ablation or treating DTC metastases. 117 patients with DTC for I-131 therapy were monitored through the video and intercommunicating with standardized questionnaire at different time points after I-131 oral administration. Adverse effects were recorded and relevant clinical factors were analyzed. Among all the 117 patients, 55 cases complained of neck's pain or swelling and 79 cases presented with gastrointestinal symptoms. Pain or swelling of salivary gland occurred in 15 patients, headache and vertigo in 10, insomnia in 9, vocal cord paralysis in 6, fatigue or general malaise in 6, and foreign body sensation in 5. Body numbness and urinary symptoms were observed in only 1 case, respectively. Those side effects were related with sex, pre-I-131 treatment TSH levels, frequency of I-131 therapy, and lymph node metastases. Short-term side effects after I-131 therapy for DTC patients varied individually; severe symptoms were not uncommon but generally did not need emergent medical intervention.

  1. Radioactive Iodine Therapy Decreases Recurrence in Thyroid Papillary Microcarcinoma

    PubMed Central

    Creach, Kimberly M.; Siegel, Barry A.; Nussenbaum, Brian; Grigsby, Perry W.

    2012-01-01

    Background. The most appropriate therapy for papillary microcarcinoma (PMC) is controversial. Methods. We reviewed the therapy and outcome of 407 patients with PMC. Results. Three hundred-eighty patients underwent total thyroidectomy, and 349 patients received I-131 therapy. The median followup was 5.3 years. Forty patients developed recurrent disease. On univariate analysis, development of disease recurrence was correlated with histological tumor size > 0.8 cm (P = 0.0104), age < 45 years (P = 0.043), and no I-131 therapy (P < 0.0001). On multivariate analysis, histological tumor size > 0.8 cm, positive lymph nodes, and no I-131 therapy were significant. The 5-year RFS for patients treated with I-131 was 95.0% versus 78.6% (P < 0.0001) for patients not treated with I-131. Patients with lymph node metastasis who did not receive I-131 had a 5-year RFS of 42.9% versus 93.2% (P < 0.0001) for patients who received I-131. Conclusions. Recommend I-131 remnant ablation for patients with PMC, particularly patients with lymph node metastasis. PMID:22462017

  2. Diagnosis and treatment of neuroblastoma using metaiodobenzylguanidine

    SciTech Connect

    Edeling, C.J.; Frederiksen, P.B.; Kamper, J.; Jeppesen, P.

    1987-08-01

    Neuroblastoma is a lethal and not uncommon tumor in childhood. Early detection and display of the spread of the tumor is highly desirable for proper treatment. Nine children suspected of having neuroblastomas were examined by I-131 metaiodobenzylguanidine (I-131 MIBG) imaging. In two recent studies I-123 metaiodobenzylguanidine (I-123 MIBG) was used. A primary adrenal neuroblastoma was correctly identified in three cases. In two patients additional tumor sites were found. In one patient, who was in complete remission, no pathologic accumulation of I-131 MIBG was found. I-131 MIBG images were also normal in four patients with other types of neoplastic diseases. A boy with multiple metastases was treated with 100 mCi of I-131 MIBG. He developed transient gastrointestinal illness and there was no regression of the tumor deposits. In one girl with a large adrenal neuroblastoma high uptake of I-131 MIBG was observed. She received two therapy doses of I-131 MIBG (35 mCi and 75 mCi) with curative intention giving a total absorbed dose in the tumor of approximately 76 Gy. In spite of high retention of radioactivity in the tumor, regression did not occur, but her general condition was improved. In the present study, images of superior quality were obtained with I-123 MIBG imaging. It is concluded that imaging using I-131 MIBG or I-123 MIBG should be used in both the initial evaluation and the follow-up of children with neuroblastoma.

  3. El sistema ESO 296-IG 11

    NASA Astrophysics Data System (ADS)

    Agüero, E. L.; Paolantonio, S.

    El objeto ESO 296-IG 11 que se presenta en forma de ``V'' y posee destacadas condensaciones a lo largo de cada una de sus dos ramas, las que son de igual extensión (~ 1'), es estudiado en base a material espectroscópico obtenido en el CASLEO. Así se establecen las principales características espectrales, las condiciones físicas y los mecanismos de excitación dominantes de las zonas más notables de su estructura, como así también la distribución de su extinción interna y la variación del grado de excitación de las mismas. Del análisis de las velocidades radiales se determina que se trata de dos galaxias de tipo disco que se están interpenetrando y que conforman un sistema triple junto con una galaxia de contorno elíptico y tamaño considerablemente menor (0.2') que se encuentra a ~ 1.3' del punto de intersección de las dos primeras, ubicada sobre la dirección que contiene a una de éstas y hacia la que se extienden unas débiles y largas prolongaciones de la otra.

  4. Iodine-131 uptake in a patient with thyroid cancer and rheumatoid arthritis during acupuncture treatment

    SciTech Connect

    Otsuka, N.; Fukunaga, M.; Morita, K.; Ono, S.; Nagai, K.; Katagiri, M.; Harada, T.; Morita, R. )

    1990-01-01

    A patient with thyroid carcinoma had abnormal accumulation of I-131 in the areas of both feet and hands on whole body scan. The sites of abnormal accumulation of I-131 were similar to those on bone scintigraphy. The radiographic examination of the lesions showed characteristic findings of rheumatoid arthritis, and the presence of small gold needles for acupuncture treatment was demonstrated. There were no findings of bone metastases. Although the mechanism of accumulation of I-131 in this patient is unknown, interpreters of I-131 whole body scintigraphs should keep this case in mind when acupuncture treatment has been done. The authors can only speculate on a common blood flow mechanism for enhanced HMDP and I-131 uptake in this arthritic patient who had been treated by acupuncture.

  5. Plant iodine-131 uptake in relation to root concentration as measured in minirhizotron by video camera:

    SciTech Connect

    Moss, K.J.

    1990-09-01

    Glass viewing tubes (minirhizotrons) were placed in the soil beneath native perennial bunchgrass (Agropyron spicatum). The tubes provided access for observing and quantifying plant roots with a miniature video camera and soil moisture estimates by neutron hydroprobe. The radiotracer I-131 was delivered to the root zone at three depths with differing root concentrations. The plant was subsequently sampled and analyzed for I-131. Plant uptake was greater when I-131 was applied at soil depths with higher root concentrations. When I-131 was applied at soil depths with lower root concentrations, plant uptake was less. However, the relationship between root concentration and plant uptake was not a direct one. When I-131 was delivered to deeper soil depths with low root concentrations, the quantity of roots there appeared to be less effective in uptake than the same quantity of roots at shallow soil depths with high root concentration. 29 refs., 6 figs., 11 tabs.

  6. Radioiodine uptake following iodine-131 therapy for Graves' disease: an early indicator of need for retreatment

    SciTech Connect

    Carpentier, W.R.; Gilliland, P.F.; Piziak, V.K.; Petty, F.C.; McConnell, B.G.; Verdonk, C.A.; Ibarra, J.D.; Thompson, J.Q.

    1989-01-01

    Forty-five patients with Graves' disease were studied prospectively to determine if 24-hour I-131 uptake measurements alone or in combination with serum thyroid hormone levels at six weeks would determine the necessity for retreatment of the thyrotoxicosis. All patients with an I-131 uptake greater than 30% at six weeks required retreatment. No patient with an I-131 uptake of less than 15% required retreatment. Patients with uptakes between 15% and 30% were variable. An elevated free thyroxin index at 6 weeks is not helpful to determine which patients will remain thyrotoxic. Patients with a free thyroxin index within the normal range at six weeks can be predicted to be euthyroid by 12 weeks if their 24-hour I-131 uptake is between 15% and 30% and to be hypothyroid if their 24-hour I-131 uptake is below 15%. There was no difference between patient groups treated initially with antithyroid medication and those who were not.

  7. Desarrollo y validación de una nueva tecnología, basada en arginina al 1.5%, un compuesto de calcio insoluble y fluoruro, para el uso diario en la prevención y tratamiento de la caries dental.

    PubMed

    Cummins, D

    2013-10-22

    este artículo discute brevemente la prevalencia de caries, la naturaleza multifactorial de su etiología, el riesgo de caries y el papel y eficacia del fluoruro. Resalta también la investigación sobre el metabolismo bacteriano, que ha aportado conocimientos sobre la defensa natural oral contra la caries y la base para el desarrollo de una nueva tecnología para la prevención diaria y el tratamiento de la caries. Por último, se resume la evidencia que respalda que la tecnología complementa y mejora la eficacia anti-caries de la crema dental con fluoruro. los datos globales muestran que a pesar de la exitosa introducción del fluoruro, la caries dental es una enfermedad prevalente. La experiencia de caries depende del balance entre el consumo de azúcares, la higiene oral y el uso del fluoruro. Hay tres conceptos científicos que son fundamentales en las nuevas mediciones para detectar, tratar y monitorear la caries: (1) la caries dental es un proceso dinámico, (2) la caries dental es un proceso continuo de etapas que van desde reversible (pre-clínica) hasta irreversible (lesiones clínicamente detectables), y (3) el proceso de la caries es un balance de factores patológicos y protectores que pueden modularse para el manejo de la caries. El fluoruro funciona como factor protector al detener y revertir el proceso de la caries, pero el fluoruro no previene los factores patológicos que inician el proceso. Se ha identificado una tecnología novedosa, basada en arginina y un compuesto insoluble de calcio, que está dirigida a la placa dental para prevenir la iniciación del proceso de caries al reducir los factores patológicos. Como los mecanismos de acción de la arginina y el fluoruro son altamente complementarios, se ha desarrollado un nuevo dentífrico que combina la arginina y el fluoruro, y se ha probado clínicamente que brinda una prevención superior contra la caries. Copyright © 2013 Elsevier Ltd. All rights reserved.

  8. La formación de la Nube de Oort y el entorno galáctico primitivo

    NASA Astrophysics Data System (ADS)

    Fernández, J. A.

    Se analizan las condiciones de formación de la nube de Oort en el medio galáctico primitivo, bajo la suposición de que los objetos que alcanzaron la nube fueron planetesimales residuales eyectados por los planetas gigantes durante las etapas finales de su acreción. Los objetos que adquieren órbitas cuasiparabólicas están sujetos a las perturbaciones de estrellas vecinas y al potencial del disco galáctico, las que desacoplan sus perihelios de la región planetaria, dando a los objetos una larga estabilidad dinámica. Se demuestra que un entorno galáctico como el presente pudo, sin embargo, no ser suficiente para formar un reservorio cometario con una vida dinámica comparable a la vida del sistema solar. La existencia de la nube de Oort después de 4600 millones de años es, pues, una fuerte indicación de que el sistema solar se formó en un entorno galáctico mucho mas denso que el presente, tal vez en una nube molecular y/o un cúmulo abierto, que es el modo de producción de la mayoría de las estrellas. Se encuentra que un campo perturbador externo mas intenso, producto de un entorno galáctico mas denso, sería capaz de formar una nube de Oort mas compacta, con un radio del orden de 103- 104 UA. El campo externo mas intenso cesó de actuar una vez que la nube molecular y/o el cúmulo abierto se disiparon, previniendo entonces que ese mismo campo externo disolviera el reservorio cometario.

  9. Radioiodine-induced hypothyroidism in Graves' disease: factors associated with the increasing incidence

    SciTech Connect

    Cunnien, A.J.; Hy, I.D.; Gorman, C.A.; Offord, K.P.; Scanlon, P.W.

    1982-11-01

    A retrospective analysis was done of the records of 454 patients who received their first I-131 treatment for Graves' disease during six periods covering 1951 to 1978. In the earliest group, 3% of patients were hypothyroid 3 mo after I-131 use, and 40% were hypothyroid at 1 yr. In the most recent group, 36% of patients were hypothyroid at 3 mo and 91% were myxedematous at 1 yr. Although no obvious trends were noted, whether in the number of patients pretreated with thionamide drugs, in the mean 24-hr I-131 uptake, or in the calculated dose of I-131 (..mu..Ci/estimated gram of thyroid tissue) during the years of the study, the initial mean dose of I-131 administered increased from 8.1 mCi in the earliest group to 13.8 mCi in the latest group. Concurrently, estimates of gland size increased from a mean of 26 g in the first group to 43 g in the last. If, in patients with Graves' disease, the thyroid gland size did not truly increase during the years of the study, the increasing occurrence of early hypothyroidism seen after I-131 use may reflect the conscious or unconscious decision to use larger doses of I-131 calculated on the basis of inflated estimates of thyroid gland weight.

  10. Relationship between orally administered dose, surface emission rate for gamma radiation, and urine radioactivity in radioiodine-treated hyperthyroid cats.

    PubMed

    Feeney, Daniel A; Jessen, Carl R; Weichselbaum, Ralph C; Cronk, Daniel E; Anderson, Kari L

    2003-10-01

    To determine the relationship between surface emission rate of gamma radiation and urine concentration of I131 (urine radioactivity) during the period 7 to 21 days after oral or SC administration of I131 to hyperthyroid cats. 47 hyperthyroid cats administered I131 PO and 24 hyperthyroid cats administered I131 SC. A dose of I131 (1.78 to 2.04 X 10(2) MBq [4.8 to 5.5 mCi]) was administered orally. Surface emission at the skin adjacent to the thyroid gland on days 7, 10, 14, 18, and 21 and number of counts/30 s in a urine sample (1 mL, obtained via cystocentesis) on days 7, 14, and 21 after oral administration were measured. Effective half-life (T1/2E) was derived for each point. Surface emission thresholds for maximum urine radioactivity values were established. A dose of I131 (1.48 X 10(2) MBq [4.0 mCi]) was administered SC. Urine radioactivity and surface emission rates for SC administration were compared with values for oral administration. The T1/2E for surface emissions and urine radioactivity progressively increased toward values for physical T1/2 over time. The T1/2E for surface emissions was 2.19 to 4.70 days, and T1/2E for urine radioactivity was 2.16 to 3.67 days. Surface emission rates had a clinically useful threshold relationship to maximum urine concentrations of I131. Surface emission rates for cats administered I131 appeared useful in determining upper limits (threshold) of urine radioactivity and are a valid method to assess the time at which cats can be discharged after I131 administration.

  11. Incidence of hypothyroidism occurring long after iodine-131 therapy for hyperthyroidism

    SciTech Connect

    Holm, L.E.; Lundell, G.; Israelsson, A.; Dahlqvist, I.

    1982-02-01

    We have studied the long-term incidence of hypothyroidism in 4,473 formerly hyperthyroid patients given I-131 therapy between 1951 and 1975. The mean age at the first I-131 treatment was 56 yr. Six percent developed hypothyroidism within one year of therapy, and 72% within 26 yr. Prior antithyroid medication did not affect the incidence of hypothyroidism. Patients cured with one dose of I-131 had a lower cumulative long-term incidence of hypothyroidism than those requiring more than one dose.

  12. Meningococco B: controllo di due focolai epidemici mediante vaccinazione

    PubMed Central

    2014-01-01

    Riassunto La problematica di un efficace approccio vaccinale nei confronti del Meningococco B (MenB) è stata superata identificando con la metodica della "reverse vaccinology" alcuni antigeni capaci di indurre una risposta verso la maggior parte dei ceppi di MenB circolanti nel mondo. Il nuovo vaccino MenB a 4 componenti (4CMenB) è stato autorizzato in Europa, Australia e Canada, ed è entrato nei calendari di immunizzazione pediatrica internazionali: Australia, Canada, UK. In Italia, le prime regioni che hanno raccomandato la vaccinazione contro il MenB sono state Basilicata e Puglia. La gestione di epidemie/focolai epidemici richiede la messa in atto di una risposta rapida da parte delle autorità sanitarie nei confronti di una emergenza sanitaria ad elevato impatto, anche emotivo, sulla popolazione, come recentemente dimostrato in due università americane. Alla dichiarazione di focolaio epidemico in atto, in entrambi i contesti si è attivata una procedura per l'uso del vaccino 4CMenB non ancora autorizzato negli USA. È stato così possibile organizzare gli interventi di profilassi attiva nei due campus universitari, adottando il primo impiego su larga scala del nuovo vaccino 4CMenB e conseguendo, in tempi relativamente brevi, elevati tassi di copertura vaccinale. A fronte di circa 14000 studenti immunizzati con almeno una dose, non è stata segnalata alcuna problematica di eventi avversi conseguenti all'immunizzazione; ad oggi non si sono verificati casi nei soggetti che hanno ricevuto il vaccino. Come conseguenza dei due focolai descritti, è oggi in corso la valutazione da parte dell'FDA per l'estensione dell'uso del vaccino 4CMenB negli Stati Uniti negli adolescenti e giovani adulti. PMID:25916017

  13. 8 CFR 223.2 - Processing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., AND ADVANCE PAROLE DOCUMENTS § 223.2 Processing. (a) General. An application for a reentry permit, refugee travel document, or advance parole document must be filed on Form I-131, with the fee required...

  14. Portrayal of pheochromocytoma and normal human adrenal medulla by m-(123I)iodobenzylguanidine: concise communication

    SciTech Connect

    Lynn, M.D.; Shapiro, B.; Sisson, J.C.; Swanson, D.P.; Mangner, T.J.; Wieland, D.M.; Meyers, L.J.; Glowniak, J.V.; Beierwaltes, W.H.

    1984-04-01

    The radiopharmaceutical m-(131I)iodobenzylguanidine (I-131 MIBG), which is readily taken up by adrenergic vesicles, produces scintigraphic images of pheochromocytomas in man but rarely visualizes normal adrenal glands. Iodine-123 has many potential advantages over I-131 as a radiolabel for MIBG, including shorter half-life, freedom from beta emissions, and increased gamma-camera efficiency. In this study, diagnostic doses of MIBG labeled with I-131 and I-123, with nearly equivalent radiation dosimetry, were compared as imaging agents in eight patients with known or suspected pheochromocytoma. Images of superior quality were obtained with I-123 MIBG, and lesions not visualized using I-131 MIBG were portrayed. In addition, the normal adrenal medullae were visualized on the I-123 MIBG scintigrams in six out of eight patients.

  15. Treatment of neuroblastoma with /sup 131/I-metaiodobenzylguanidine: experience of the Muenster/Kassel Group

    SciTech Connect

    Fischer, M.; Wehinger, H.; Kraus, C.; Ritter, J.; Schroeter, W.

    1987-01-01

    I-131-metaiodobenzylguanidine was used for treatment of neuroblastoma stage IV in three children after surgery and or chemotherapy had failed to be effective. In two of the children with multilocular lesions, after an impressive improvement of clinical symptoms tumor progression was observed. Because in about 25% of children with relapsing neuroblastoma complete remission may be achieved by combining surgery, chemotherapy, and I-131-MIBG treatment, this therapeutic modality should be included in the therapeutic strategy of stage III and IV neuroblastoma.

  16. False-positive iodine-131 body scan caused by a large renal cyst

    SciTech Connect

    Brachman, M.B.; Rothman, B.J.; Ramanna, L.; Tanasescu, D.E.; Adelberg, H.; Waxman, A.D.

    1988-06-01

    Focal I-131 accumulation is generally a reliable indicator of functioning thyroid tissue or a differentiated thyroid cancer metastasis. Normal accumulation of activity may be seen in areas such as the intestinal tract, liver, and salivary glands. This report describes a patient with significant accumulation of I-131 in the right upper quadrant of the abdomen. The abnormality, first thought to represent metastatic thyroid carcinoma, was subsequently proven to be accumulation within a large renal cyst.

  17. Beers versus STOPP criteria in polyharmacy community-dwelling older patients.

    PubMed

    Nicieza-Garcia, Maria Luisa; Salgueiro-Vázquez, Maria Esther; Jimeno-Demuth, Francisco José; Manso, Gloria

    2016-05-01

    Objetivo: Evaluar la prescripcion potencialmente inapropiada (PPI) mediante la aplicacion de los criterios Beers (version 2012) y STOPP (version 2008) en pacientes mayores, polimedicados y residentes en la comunidad. Metodos: A partir de la informacion recogida en los datos de facturacion de recetas y de las historias clinicas electronicas se selecciono una muestra de 223 pacientes de 65 o mas anos, que tomaban simultaneamente 10 o mas medicamentos/dia. Se aplicaron separadamente los criterios de Beers y STOPP y se compararon los resultados obtenidos con ambos metodos. Resultados: Un total de 141 pacientes (63,2%) presentaban al menos un criterio de Beers. Los dos criterios de Beers independientes del diagnostico observados con mas frecuencia fueron el uso de benzodiazepinas y el uso de antiinflamatorios no esteroideos no selectivos de ciclooxigenasa-2. Con respecto a los criterios de Beers considerando el diagnostico, los mas frecuentes fueron el uso de anticolinergicos en pacientes con sintomas del tracto urinario inferior o con hiperplasia benigna de prostata y el uso de benzodiazepinas, antipsicoticos, zolpidem o antihistaminicos H2, en pacientes con demencia o deterioro cognitivo. Un total de 165 (73,9%) pacientes tenian al menos una PPI segun los criterios STOPP. La duplicidad terapeutica y el uso prolongado de benzodiazepinas de vida media larga fueron los dos criterios STOPP mas comunes. Discusion: Nuestro estudio identifico una alta frecuencia de PPI en pacientes mayores, polimedicados y residentes en la comunidad. La aplicacion simultanea de los criterios de Beers y STOPP constituye una herramienta util para mejorar la prescripcion en este grupo de poblacion.

  18. Cancer risk following radioactive iodine-131 exposures in medicine

    SciTech Connect

    Ron, E.

    1997-03-01

    Most types of cancer have been associated with external radiotherapy and exposures from the atomic bombs in Hiroshima and Nagasaki. Although epidemiologic, and some experimental studies, suggest that iodine-131 (I-131) may be less effective in inducing malignancies, the potential late health effects of I-131 remain a concern to both the general public and the medical community. Other radionuclides are currently used for diagnosis, but it is estimated that over 10 million adults have had I-131 treatment of choice for hyperthyroidism and is used frequently to treat thyroid cancer. Since 1942, when I-131 therapy for hyperthyroidism was introduced, millions of patients, almost all adults, have had this treatment. In contrast to the substantial medical use of iodine-131 in adults, its use in children and adolescents has been extremely limited because of concerns regarding its long-term carcinogenic and genetic effects. Some physicians, however, are advising re-evaluation of treatment for children because it is convenient, effective and relatively inexpensive. Over the last few decades, case reports and some small epidemiologic studies have linked medical exposure to I-131 with thyroid cancer and leukemia. Attention also has focused on breast cancer and cancers occuring in organs that concentrate appreciable quantities of iodine, i.e. salivary glands, stomach, kidney, and bladder. In this report, the author briefly summarizes the major epidemiologic studies of medical exposures to I-131 and compares the results with what is known about external radiation exposure.

  19. Thyroglobulin levels to follow-up patients with treated differentiated thyroid carcinoma

    SciTech Connect

    Moser, E.; Braun, S.; Bueell, U.; Kirsch, C.M.; Tosch, U.; Wendt, T.

    1984-01-01

    Serum thyroglobulin (hTg) measurements by commercial radioimmunoassay were performed in the follow-up of 118 patients with differentiated thyroid carcinoma undergoing I-131 local and whole-body scans following surgery and I-131 therapy. Patients with positive anti-hTg antibodies (23% of cases) were excluded. In all remaining I-131 accumulating residual, recurrent, or metastatic tumors, hTg levels were elevated (greater than 6.25 ng/ml, minimum detectable value). Twelve patients with neither recurrence nor metastases had elevate hTg levels. Sensitivity and specificity depended on the threshold used for elevate hTg levels. At an hTg-threshold of 6.25 ng/ml sensitivity has 100%, specificity has 82%. As hTg levels were reported to depend on endogenous TSH stimulation, it is not yet advisable to replace I-131 scans totally by hTg determination. After having determined an hTg ''baseline'' below detectable values (less than 6.25 ng/ml), we reduced the number of I-131 scans by half. However, elevated hTg levels were an indication for an I-131 scan. Therefore, on the basis of 23% of our patients who had anti-hTg antibodies the need exists to develop a commercial assay which is independent from antibodies.

  20. Adjuvant Iodine131 Lipiodol after Resection of Hepatocellular Carcinoma

    PubMed Central

    Furtado, Ruelan V.; Ha, Leo; Clarke, Stephen; Sandroussi, Charbel

    2015-01-01

    Background. Survival after liver resection for HCC is compromised by a high rate of intrahepatic recurrence. Adjuvant treatment with a single, postoperative dose of intra-arterial I131 lipiodol has shown promise, as a means of prolonging disease-free survival (DFS). Methodology. DFS and overall survival (OS) after a single dose of postoperative I131 lipiodol were compared to liver resection alone, for treatment of hepatocellular carcinoma (HCC). Data were collected retrospectively for patients who had a curative resection for HCC between December 1993 and September 2011. Seventy-two patients were given I131 lipiodol after surgery and 70 patients had surgery alone. Results. The DFS at 1, 3, and 5 years was 72%, 43%, and 26% in the surgery group and 70%, 39%, and 29% in the adjuvant I131 lipiodol group (p = 0.75). The 1-, 3-, and 5-year OS was 83%, 64%, and 52% in the surgery group and 96%, 72%, and 61% in the adjuvant I131 lipiodol group (p = 0.16). Conclusion. This retrospective study has found no significant benefit to survival, after adjuvant treatment with I131 lipiodol. PMID:26713092

  1. Recuerdos de una revolucion cultural (Memories of a Cultural Revolution)

    ERIC Educational Resources Information Center

    Carvalho-Neto, Paulo de

    1973-01-01

    Describes elements of the modernism movement in Brazil; paper read at a symposium commemorating the fiftieth anniversay of the Week of Modern Art of Sao Paulo'' held February 11-12, 1972, at the University of California, Los Angeles, California. (DS)

  2. Esercitazioni Matematiche: Una Rivista Ad uso Degli Studenti Universitari.

    ERIC Educational Resources Information Center

    Micale, Biagio

    1992-01-01

    The history of the journal "Esercitazioni Matematiche" (1921-43) edited by the "Circolo Matematico di Catania" for university students is described. A selection of proposed problems with some of their solutions is reported. (Author)

  3. La Ciencia de los Antiguos Mexicanos: Una Bibliografia Selecta

    ERIC Educational Resources Information Center

    Ortiz-Franco, Luis; Magana, Maria

    1973-01-01

    Fifty-five citations pertaining to the scientific and mathematic development of ancient Mexicans, particularly the Mayas, are given in this select bibliography. The introduction and descriptions of resource libraries in 8 States are in Spanish. (NQ)

  4. Una Perspectiva de Mexico: Its People, Places and History.

    ERIC Educational Resources Information Center

    Bianchi, Gary; Bianchi, Maria Eugenia Matute

    Evolving from a general commitment to the goals of cultural pluralism and bicultural education, this portfolio of 24 full color and halftone photographs aims to reinforce those curricular objectives which emphasize a respect for the value and individuality of different cultures and groups, affirm the right of an individual to maintain a bicultural…

  5. Suvali Una? (And What Is This One Doing?).

    ERIC Educational Resources Information Center

    MacLean, Edna Ahgeak

    This bilingual reader in the Barrow Inupiaq language and in English is intended for beginning readers on the elementary school level. Pen-and-ink drawings illustrate the text and a free English translation is appended. (NCR)

  6. Etimologia in una lingua pianificata (Etymology in a Planned Language).

    ERIC Educational Resources Information Center

    Minnaja, Carlo

    2002-01-01

    Discusses the fifth volume of the "Etimologia Vortaro de Esperanto" (Etymological Dictionary of Esperanto). The dictionary provides not only the etynom of each Esperanto term, but also the etymology of the ethnic language words from which the editor derived the terms in question. (Author/VWL)

  7. Una Perspectiva de Mexico: Its People, Places and History.

    ERIC Educational Resources Information Center

    Bianchi, Gary; Bianchi, Maria Eugenia Matute

    Evolving from a general commitment to the goals of cultural pluralism and bicultural education, this portfolio of 24 full color and halftone photographs aims to reinforce those curricular objectives which emphasize a respect for the value and individuality of different cultures and groups, affirm the right of an individual to maintain a bicultural…

  8. El Espanol, una Lengua "Familiar." (Spanish, an Informal Language)

    ERIC Educational Resources Information Center

    Criado de Val, Manuel

    1976-01-01

    This article describes what is perceived as a gradual relaxation of language usage norms in Spanish, and calls for the creation of a center to help modernize technical Spanish and to minimize the intrusion of English technical vocabulary. (Text is in Spanish.) (CLK)

  9. Esercitazioni Matematiche: Una Rivista Ad uso Degli Studenti Universitari.

    ERIC Educational Resources Information Center

    Micale, Biagio

    1992-01-01

    The history of the journal "Esercitazioni Matematiche" (1921-43) edited by the "Circolo Matematico di Catania" for university students is described. A selection of proposed problems with some of their solutions is reported. (Author)

  10. La Ciencia de los Antiguos Mexicanos: Una Bibliografia Selecta

    ERIC Educational Resources Information Center

    Ortiz-Franco, Luis; Magana, Maria

    1973-01-01

    Fifty-five citations pertaining to the scientific and mathematic development of ancient Mexicans, particularly the Mayas, are given in this select bibliography. The introduction and descriptions of resource libraries in 8 States are in Spanish. (NQ)

  11. The Understanding of Astronomy Concepts by Students from Basic Education of a Public School. (Spanish Title: El Entendimiento de Conceptos de Aastronmía Por Los Alumnos de Educación Básica en Una Escuela Pública.) O Entendimento de Conceitos de Astronomia Por Alunos da Educação Básica: O Caso de Uma Escola Pública Brasileira

    NASA Astrophysics Data System (ADS)

    Iria Machado, Daniel; dos Santos, Carlos

    2011-07-01

    We present the results obtained in a research on the comprehension of basic astronomical concepts, in which 561 students from fifth grade middle school to third grade high school of a public school of the city of Foz do Iguaçu (Brazil) took part. A test with 20 multiple-choice questions was applied to indentify the most common conceptions expressed by the students. This test was elaborated based on the literature about misconceptions and covered the following topics: the day-night cycle; the time zones; the seasons of the year; the phases of the Moon; the movement of the Moon; the apparent movement of the Sun in the celestial sphere; the eclipses; the dimensions and distances in the Universe; the brightness of the stars and its observation from Earth. Though a small progress was verified in the proportion of scientifically acceptable answers when comparing the eighth grade of middle school to the fifth, and the third grade of high school to the first, there was an overall predominance of alternative conceptions regarding most of the explored subjects, which persisted up to the last year of secondary school. The comparison to data found in this research made in other socio-cultural contexts revealed, in many aspects, similar notions and difficulties revealed by the students. Se presentan los resultados de una investigación sobre la comprensión de conceptos astronómicos básicos, en la cual participaron 561 estudiantes que cursaban entre el quinto grado de la enseñanza primaria y el tercer año de la enseñanza secundaria de una escuela pública de la ciudad de Foz do Iguaçu (Brasil). Se utilizó un test de 20 preguntas de opción múltiple para identificar las concepciones más comunes expresadas por los estudiantes. Este instrumento de recolección de datos se desarrolló en base a la literatura sobre las concepciones alternativas y trató los siguientes temas: el ciclo día-noche, los husos horarios, las estaciones del año, las fases de la Luna, el

  12. The Universe in a Box: Introduction to the Study of Astronomy in the Initial Formation of Physics Teachers. (Spanish Title: El Universo Representado en Una Caja: Introducción al Estudio de la Astronomía en la Formación Inicial de Profesores de Física.) O Universo Representado em Uma Caixa: Introdução ao Estudo da Astronomia NA Formação Inicial de Professores de Física

    NASA Astrophysics Data System (ADS)

    Longhini, Marcos Daniel

    2009-07-01

    This is a report of an activity of introduction to the study of Astronomy developed with a group of future Physics teachers at a Brazilian public university. Such activity had the goal of giving privileged emphasis to notions of spatiality, alternative conceptions of the participants and the process of interaction among peers, and consisted of the representation, in a three dimensional space, of the models of the universe that the participants had. The results, which were categorized as miscellaneous, geocentric, heliocentric and acentric models of the universe, were qualitatively analyzed. Analyses of the activity in the perspective of the participants are indicated and additional considerations are made regarding its use as a resource for teaching Astronomy and for teacher training. Este es el informe de una actividad para presentar un estudio introductorio de la Astronomía, desarrollado con una clase de futuros profesores de física en una universidad pública brasileña. Esta actividad tuvo como objetivo centrar las nociones de espacialidad, las concepciones alternativas de los participantes y el proceso de interacción entre pares, y consistió en la representación en un espacio tridimensional, de los modelos del universo que los participantes habían. Los resultados, que se clasificaron en universo miscelania, geocéntrico, heliocéntrico y acentrico, se analizaron cualitativamente. Son identificadas análisis de la actividad por los participantes, e hizo observaciones sobre su uso como recurso para la enseñanza de la astronomía y la formación de docentes. Trata-se do relato de uma atividade de introdução ao estudo da Astronomia, desenvolvida com uma turma de futuros professores de Física, em uma universidade pública brasileira. Tal atividade teve como meta privilegiar noções de espacialidade, as concepções alternativas dos participantes e o processo de interação entre pares e constou da representação, em um espaço tridimensional, dos

  13. ENDURANCE TRAINING IN FASTING CONDITIONS: BIOLOGICAL ADAPTATIONS AND BODY WEIGHT MANAGEMENT.

    PubMed

    Vicente-Salar, Néstor; Urdampilleta Otegui, Aritz; Roche Collado, Enrique

    2015-12-01

    Introducción: en la mayoría de las disciplinas deportivas, el deportista debe conseguir unas óptimas condiciones a nivel muscular y metabólico, así como de composición corporal, manteniendo un bajo porcentaje de grasa corporal. En este contexto se han propuesto diferentes protocolos de entrenamiento con el fin de reducir el porcentaje de grasa corporal incidiendo en un aumento de la utilización de las grasas en detrimento del glucógeno. Objetivo: comprobar si el entrenamiento en ayunas favorece el uso de ácidos grasos debido a los bajos niveles de glucógeno, permitiendo mejoras en el rendimiento y en el control del peso a partir de los estudios publicados. Resultados: los protocolos publicados difieren tanto en el periodo de trabajo como en la intensidad del ejercicio, así como respecto al análisis de una gran variedad de marcadores, desde la expresión de genes hasta parámetros circulantes. Discusión: a bajas intensidades de ejercicio aeróbico, los niveles de lipólisis y oxidación de grasas son mayores en el ejercicio en ayunas. Por otro lado, el metabolismo de la glucosa en condiciones de ayuno se adapta en relación al ahorro de las reservas de glucógeno. Finalmente, en condiciones de ayuno, la degradación de proteínas musculares se ve disminuida. Actualmente solo un estudio analiza los cambios en la composición corporal tras un protocolo de larga duración de ejercicio y ayuno, por lo que es necesario realizar más estudios con el fin de demostrar que se trata de una estrategia válida para el control del peso corporal.

  14. [Nutritional study of a third division soccer team].

    PubMed

    Martínez Reñón, Cristian; Sánchez Collado, Pilar

    2013-01-01

    Objetivo: Analizar los hábitos y actitudes nutricionales de un equipo de fútbol semiprofesional. Método: Se realizó el estudio nutricional de 21 jugadores semiprofesionales de fútbol (18-35 AÑOs) analizando la ingesta y gasto energético diario así como la distribución de los macro- y micronutrientes diferenciado el tipo de día (normal, entrenamiento y competición). Resultados: El balance energético es negativo en los tres días estudiados (-31%; -38 % y 31-% respectivamente). Se observan diferencias significativas en la ingesta calórica el día de la competición respecto al día normal y al de entrenamiento tanto en valores absolutos (2.438 kcal vs 2.127 y 2.221 kcal respectivamente) como referida al peso corporal (30,5 kcal/kg vs 27 y 28 kcal/kg respectivamente). Con respecto a la ingesta de macronutrientes la muestra ingiere una dieta con una cantidad insuficiente de hidratos de carbono (328 g vs 371 y 540 g recomendados según actividad física). No se obtuvieron diferencias significativas en la composición de micronutrientes Conclusiones: Los jugadores de fútbol estudiados presentan un balance energético negativo con una dieta pobre en hidratos de carbono. Este estado nutricional deficiente puede interferir en el desarrollo de su prestación deportiva y a la larga incrementar el riesgo de lesiones. Esto implica la necesidad de realizar un diseño e implementación de la dieta y la introducción de programas de educación nutricional para este tipo de deportistas.

  15. Retrospective reconstruction of Ioidne-131 distribution at the Fukushima Daiichi Nuclear Power Plant accident by analysis of Ioidne-129

    NASA Astrophysics Data System (ADS)

    Matsuzaki, Hiroyuki; Muramatsu, Yasuyuki; Toyama, Chiaki; Ohno, Takeshi; Kusuno, Haruka; Miyake, Yasuto; Honda, Maki

    2014-05-01

    Among various radioactive nuclides emitted from the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident, Iodine-131 displayed high radioactivity just after the accident. Moreover if taken into human body, Iodine-131 concentrates in the thyroid and may cause the thyroid cancer. The recognition about the risk of Iodine-131 dose originated from the experience of the Chernobyl accident based on the epidemiological study [1]. It is thus important to investigate the detailed deposition distribution of I-131 to evaluate the radiation dose due to I-131 and watch the influence on the human health. However I-131 decays so rapidly (half life = 8.02 d) that it cannot be detected several months after the accident. At the recognition of the risk of I-131 on the Chernobyl occasion, it had gone several years after the accident. The reconstruction of I-131 distribution from Cs-137 distribution was not successful because the behavior of iodine and cesium was different because they have different chemical properties. Long lived radioactive isotope I-129 (half life = 1.57E+7 yr,), which is also a fission product as well as I-131, is ideal proxy for I-131 because they are chemically identical. Several studies had tried to quantify I-129 in 1990's but the analytical technique, especially AMS (Accelerator Mass Spectrometry), had not been developed well and available AMS facility was limited. Moreover because of the lack of enough data on I-131 just after the accident, the isotopic ratio I-129/I-131 of the Chernobyl derived iodine could not been estimated precisely [2]. Calculated estimation of the isotopic ratio showed scattered results. On the other hand, at the FDNPP accident detailed I-131 distribution is going to be successfully reconstructed by the systematical I-129 measurements by our group. We measured soil samples selected from a series of soil collection taken from every 2 km (or 5km, in the distant area) meshed region around FDNPP conducted by the Japanese Ministry of

  16. [Evaluation of the nutritional status, insulin resistance and cardiovascular risk in a population of adolescents in the cities of Granada and Almeria (Spain)].

    PubMed

    Montero Alonso, Miguel A; González-Jiménez, Emilio

    2013-01-01

    Objetivos: Los objetivos de este estudio fueron evaluar el estado nutricional e índice de resistencia insulínica mediante HOMA en una población de adolescentes, así como establecer correlaciones entre el estado nutricional de los sujetos, la existencia o no de resistencia a la acción insulínica y el riesgo de padecer hipertensión arterial. Muestra y metodología: Una población de 1001 adolescentes de entre 9 y 17 años de edad, pertenecientes a 18 centros educativos de las provincias de Granada y Almería. Se realizó una valoración completa del estado nutricional de los alumnos mediante antropometría. Para el estudio metabólico, se practicó una extracción sanguínea mediante punción venosa a cada alumno, analizando glucosa basal, insulina basal, índice HOMAIR. Además, se valoró hemoglobina glicosilada (HBA1c), niveles séricos de lipoproteína (a) y ácidos grasos de cadena larga (NEFA). Para el cálculo del índice de resistencia a la insulina, se utilizó el modelo matemático propuesto por Matthews (Homeostasis Model Assessment - HOMAIR), aplicando la fórmula HOMAIR = (insulina x glucosa)/22,5. Resultados: La valoración del estado nutricional reveló un progresivo incremento en los valores de las variables antropométricas a medida que el estado nutricional de los sujetos empeoraba, describiéndose una prevalencia de normopeso del 85,01%, frente a una tasa de sobrepeso del 9,99% y de obesidad del 4,99% para ambos sexos y con independencia de la edad. El estudio metabólico evidenció niveles séricos significativamente más elevados (p < 0,0001) de HBA1c, insulina basal, glucemia basal, NEFA basal, lipoproteína (a) y HOMA IR entre adolescentes con obesidad frente a aquellos otros en situación de normopeso o sobrepeso. Conclusiones: La obesidad constituye un grave problema de salud entre la población de adolescentes estudiada, determinado el desarrollo precoz de trastornos metabólicos, hasta ahora propios de la etapa adulta circunstancia

  17. A Diagnostic Assessment for the Teaching of Astronomy. (Spanish Title: Una Evaluación Diagnóstica Para la Enseñanza de la Astronomia.) Uma Avaliação Diagnóstica Para o Ensino da Astronomia

    NASA Astrophysics Data System (ADS)

    Pacifico Ribeiro de Assis Silveira, Felipa; Soares Gomes de Sousa, Célia Maria; Moreira, Antonio

    2011-07-01

    This article aims to present the results of a diagnostic evaluation, used as a tool for collecting data on prior knowledge of scientific concepts needed to understand the topic "Earth and Universe", from a group comprised of 47 students of 6th grade. The educational method of diagnosing the student's prior knowledge before teaching them is founded on the Meaningful Learning theory, proposed by David Ausubel. The diagnostic evaluation consisted of 25 questions; the answers were analyzed and categorized, making possible their interpretation, which allows us to understand the meanings assigned by the student to these concepts. It follows from the diagnostic evaluation, that the majority of students surveyed had difficulties in exposing scientific concepts on the topic "Earth and Universe" when starting the 6th grade. However, we identified relevant ideas and representations that contributed to the re-signification of scientific concepts proposed for the teaching of the subject in this grade. The results of diagnostic evaluation served as reference to the organization of the syllabus, making possible the learning process by matching the sequence of teaching to the students" characteristics and context of the classroom. It is expected that other researchers in this topic can also use the instrument presented in this paper. Este artículo tiene como objetivo presentar los resultados de una evaluación diagnóstica, utilizada como una herramienta para recoger datos sobre el conocimiento previo de los conceptos científicos necesarios para comprender el tema "Tierra y Universo", de un grupo compuesto por 47 alumnos de 6º grado de la escuela primaria. La acción pedagógica del diagnóstico de los conocimientos previos del estudiante antes de enseñarles está justificada por la teoría del Aprendizaje Significativo, propuesta por David Ausubel. La evaluación de diagnóstico consistió en 25 preguntas, las respuestas fueron analizadas y clasificadas objetivando-se su

  18. Effect of decicurie doses of radioactive iodine 131 on parathyroid function

    SciTech Connect

    Glazebrook, G.A.

    1987-10-01

    Although parathyroid deficiency has been reported after administration of relatively small doses of iodine 131, reports of such deficiency after the much larger doses given in the management of thyroid cancer are notable by their absence in the literature. We observed one such patient, then instituted a prospective study. We observed a 58 percent incidence of apparently diminished parathyroid reserve among 53 patients given high doses of I 131. Susceptibility does not appear to be related to age, sex, extent of thyroid operation, operative technique, the amount of thyroidal I 131 uptake, the use of external radiation to the neck, or to the presence of parathyroid glands or of Hashimoto's disease in the operative specimen; however, susceptibility may be related to the anatomic location of the parathyroid glands in relation to the thyroid gland. The administered dose of I 131 almost reached significant levels (p = 0.1) in the present study. The initial pretreatment serum calcium levels were consistently lower among affected patients (p = 0.01), suggesting the presence of a preexisting latent impairment of parathyroid reserve which was subsequently unmasked after the administration of I 131. Thyroid cancer is compatible with very long-term survival, and therefore, there is a considerable risk of delayed chronic hypocalcemia among patients who have received large doses of I 131, particularly female patients in the premenopausal age group. These patients deserve special management surveillance.

  19. Iodine-131 Metaiodobenzylguanidine Therapy for Neuroblastoma: Reports So Far and Future Perspective

    PubMed Central

    Kayano, Daiki

    2015-01-01

    Neuroblastoma, which derives from neural crest, is the most common extracranial solid cancer in childhood. The tumors express the norepinephrine (NE) transporters on their cell membrane and take in metaiodobenzylguanidine (MIBG) via a NE transporter. Since iodine-131 (I-131) MIBG therapy was firstly reported, many trails of MIBG therapy in patients with neuroblastoma were performed. Though monotherapy with a low dose of I-131 MIBG could achieve high-probability pain reduction, the objective response was poor. In contrast, more than 12 mCi/kg I-131 MIBG administrations with or without hematopoietic cell transplantation (HCT) obtain relatively good responses in patients with refractory or relapsed neuroblastoma. The combination therapy with I-131 MIBG and other modalities such as nonmyeloablative chemotherapy and myeloablative chemotherapy with HCT improved the therapeutic response in patients with refractory or relapsed neuroblastoma. In addition, I-131 MIBG therapy incorporated in the induction therapy was proved to be feasible in patients with newly diagnosed neuroblastoma. To expand more the use of MIBG therapy for neuroblastoma, further studies will be needed especially in the use at an earlier stage from diagnosis, in the use with other radionuclide formations of MIBG, and in combined use with other therapeutic agents. PMID:25874239

  20. [Treatment with urea as an alternative to tolvaptan for the syndrome of inappropriate secretion of antidiuretic hormone].

    PubMed

    Gómez Valbuena, I; Alonso Pérez, L; Alioto, D; Cañamares Orbis, I; Ferrari Piquero, J M

    2014-07-01

    El síndrome de secreción inadecuada de la hormona antidiurética (SIADH) es una afectación que cursa con hiponatremia entre otros síntomas. Actualmente la familia de fármacos de elección para este síndrome son los vaptanes, entre ellos el tolvaptán, antagonistas de la vasopresina. La urea actúa como diurético osmótico produciendo la retención de sodio. Se presenta un caso en el que el cambio desde el tratamiento con tolvaptán a urea en el SIADH permitió mantener la respuesta, a un coste muy inferior. La paciente tenía 83 años, ingresó en nuestro Hospital al diagnosticarle una hiponatremia grave (108 mEq/L) durante una exploración por una caída en su casa. Durante el ingreso ante la sospecha de SIADH se le prescribió sucesivamente tres tipos de tratamientos: Restricción hídrica y suero salino, seguido de tolvaptán 15 mg y para finalizar se le prescribió 15 gr de urea cada 12 horas. Durante el primer tratamiento los niveles de sodio sérico no aumentaron lo suficiente, por lo que se cambió al tolvaptán, durante el cual los niveles de sodio sérico subieron a rangos normales. Al considerar que el tratamiento iba a ser de larga duración se decidió cambiar a la urea, durante el mismo los niveles de sodio sérico tuvo un ligero aumento. La paciente es dada de alta con la pauta de urea de forma indefinida. El coste diario del tratamiento de tolvaptán es de 66,91 euros; el de urea supone 0,30 euros. En casos como el descrito, el uso de urea preparada como fórmula magistral por el área de farmacotécnia del Servicio de Farmacia, es una alternativa al tolvaptán con un coste marcadamente inferior.

  1. Learning about the Sky from the Environment: An Experience Working Along One Year with Students of Elementary Education. (Spanish Title: Aprendiendo sobre EL Cielo Desde el Entorno: Una Experiencia Trabajando Durante un Año Junto a Estudiantes del Primario.) Aprendendo sobre o Céu a Partir do Entorno: Uma Experiência de Trabalho ao Longo de um Ano com Alunos de Ensino Fundamental

    NASA Astrophysics Data System (ADS)

    Longhini, Marcos Daniel; Gomide, Hanny Angeles

    2014-12-01

    Research developed with 95 students of the 6th year of elementary education in a public school of Uberlândia, Minas Gerais. It was a continuous work from February to December 2013, which led the students to participate in activities of observation of the environment, specifically the sky, analyzing the changes occurred. We focused on the study of variations in temperature, rainfall, day length, variations in the size of the shadows and changes in the aspect of the Moon. Our focus of analysis targeted the discussion of the knowledge that these students had about the topics indicated and as they entered the stage during the implementation of the proposal. The results showed a limited perception that students have of their environment, however, lately expanded due to the undertaken activities, especially in relation to the Moon. Working with systematic measure procedures reveals the careful handling of data so that they become understandable to students, and working with the shadows points towards the students first understand how shadows are formed, and then apply this knowledge to Astronomy. Finally, we conclude that the lived process consisted of an initial step of a work that should be encouraged for the subsequent years of training of these students. Proyecto de investigación desarrollado con 95 alumnos del sexto año de primaria en una escuela pública de Uberlândia, Minas Gerais. Fue un trabajo continuo, de febrero a diciembre de 2013, que llevó a los estudiantes a participar en actividades de observación de su entorno, entre ellas, el cielo, analizando los cambios ocurridos. Nos centramos en el estudio de las variaciones en la temperatura, las precipitaciones, la duración del día, las variaciones en el tamaño de las sombras y los cambios en los aspectos de la Luna. Nuestro foco de análisis se centró en discutir el conocimiento que estos estudiantes tenían sobre los temas indicados al inicio y término de la propuesta. Los resultados mostraron una

  2. [Prevalence of malnutrition in a mid-long term stay unit].

    PubMed

    Argente Pla, María; García Malpartida, Katherine; León De Zayas, Beatriz; Martín Sanchis, Silvia; Micó García, Andrea; Del Olmo García, Maria Isabel; Moral Moral, Pedro; Moreno Muñoz, Iván; Beseler Soto, Rosario; Ramos Prol, Agustín; Merino Torres, Juan Francisco

    2014-10-06

    Introducción: La desnutrición es un problema de salud frecuente, especialmente en el ámbito hospitalario donde se asocia con estancias más prolongadas y mayor tasa de morbi-mortalidad. Por otro lado, los avances científicos actuales y la mayor expectativa de vida, han producido un aumento progresivo de unidades de media y larga estancia (UMLE). Objetivos: Determinar la prevalencia de desnutrición en una UMLE mediante el uso del MNA y la VGS, así como analizar los factores/características clínicas asociadas a la misma y sus repercusiones. Métodos: Estudio transversal, descriptivo de una cohorte formada por 201 pacientes ingresados en la UMLE de un Hospital universitario de forma consecutiva durante 12 meses. Se recogieron variables clínicas, antropométricas, bioquímicas e historia nutricional, así como escala de comorbilidad de Charlson, escala cognitiva de Pfeiffer, escala funcional de Barthel y presencia de edemas, ascitis y úlceras por presión. El estado nutricional fue evaluado en las primeras 24-72 horas de ingreso mediante el MNA y la VGS. La presencia de disfagia se evaluó mediante el cuestionario EAT-10 y el MECV-V. Resultados: La prevalencia global de desnutrición fue del 76,6%, siendo la desnutrición mixta grave la más prevalente (20.4%). Los pacientes desnutridos tenían más edad (p=0,002), mayor grado de dependencia (p.

  3. [Metabolic myopathies].

    PubMed

    Papazian, Óscar; Rivas-Chacón, Rafael

    2013-09-06

    Objetivo. Revisar las miopatias metabolicas manifestadas solamente por crisis de mialgias, calambres y rigidez musculares con dificultad para contraer los musculos afectados y el examen neurologico normal entre las crisis en niños y adolescentes. Desarrollo. Estas miopatias metabolicas se deben a deficits enzimaticos heredados en forma autosomica recesiva del metabolismo de los carbohidratos y lipidos. El resultado final es una reduccion del trifosfato de adenosina principalmente a traves de la fosforilacion oxidativa mitocondrial con disminucion de la energia disponible para la contraccion muscular. Las secundarias a trastornos del metabolismo de los carbohidratos se producen por ejercicios de alta intensidad y breves (< 10 min) y las secundarias a trastornos de los lipidos, por ejercicios de baja intensidad y prolongados (> 10 min). Los deficits enzimaticos en el primer grupo son de miofosforilasa (glucogenosis V), fosfofructocinasa muscular (glucogenosis VII), fosfoglicerato mutasa 1 (glucogenosis X) y beta enolasa (glucogenosis XIII), y en el segundo, de carnitina palmitol transferasa tipo II y de acil-CoA deshidrogenasa de cadena muy larga. Conclusiones. Las caracteristicas diferenciales de los pacientes en cada grupo y dentro de cada grupo permitiran el diagnostico clinico presuntivo inicial en la mayoria y solicitar solamente los examenes necesarios para corroborar el diagnostico. El tratamiento de las crisis consiste en hidratacion, glucosa y alcalinizacion de la orina. Las medidas preventivas son evitar el tipo de ejercicio que induce las crisis y el ayuno. No existe cura o tratamiento especifico. El pronostico es bueno con la excepcion de casos raros de insuficiencia renal aguda debido a la elevacion sanguinea de la mioglobina producto de una rabdomiolisis grave.

  4. Lithium as an adjuvant of iodine-131 uptake when treating patients with well-differentiated thyroid carcinoma

    SciTech Connect

    Pons, F.; Carrio, I.; Estorch, M.; Ginjaume, M.; Pons, J.; Milian, R.

    1987-08-01

    Differences in the I-131 uptake by 14 metastatic lesions from well-differentiated thyroid carcinoma and 12 local remnants of normal thyroid tissue before and after an adjuvant therapy with lithium carbonate, were observed. After the adjuvant treatment and administration of an I-131 tracer dose, a considerable increase of radioiodine uptake in all metastatic lesions was found (P less than 0.001), but only a slight increase was found in 50% of the normal tissue. The response to lithium carbonate by neoplastic tissue seems to be different than that of the normal thyroid tissue, and produces a lengthening of the average I-131 biologic life that could be helpful when treating well-differentiated thyroid carcinoma.

  5. Effect of reserpine on salivary gland radioiodine uptake in thyroid cancer

    SciTech Connect

    Levy, H.A.; Park, C.H.

    1987-04-01

    Nine patients with thyroid cancer were treated with reserpine in an attempt to reduce radiation exposure to the salivary glands from 100-150 mCi doses of I-131 therapy to thyroid remnants or metastases. Three control patients were not treated with reserpine but did receive 100-150 mCi of I-131. Parotid/background ratios of activity after radioablative doses of I-131 in patients not treated with reserpine were significantly higher than the patients treated with reserpine, and this was also true seven days after the radioablative dose. Combined therapy with reserpine, chewing gum, lemon candies, and hydration is suggested for the prevention of sialadenitis and xerostomia due to large doses of radioiodine.

  6. Portrayal of pheochromocytoma and normal human adrenal medulla by m-(/sup 123/I)iodobenzylguanidine: concise communication

    SciTech Connect

    Lynn, M.D.; Shapiro, B.; Sisson, J.C.; Swanson, D.P.; Mangner, T.J.; Wieland, D.M.; Meyers, L.J.; Glowniak, J.V.; Beierwaltes, W.H.

    1984-04-01

    The radiopharmaceutical m-(/sup 131/I)iodobenzylguanidine (I-131 MIBG), which is readily taken up by adrenergic vesicles, produces scintigraphic images of pheochromocytomas in man but rarely visualizes normal adrenal glands. Iodine-123 has many potential advantages over I-131 as a radiolabel for MIBG, including shorter half-life, freedom from beta emissions, and increased gamma-camera efficiency. In this study, diagnostic doses of MIBG labeled with I-131 and I-123, with nearly equivalent radiation dosimetry, were compared as imaging agents in eight patients with known or suspected pheochromocytoma. Images of superior quality were obtained with I-123 MIBG. In addition, the normal adrenal medullae were visualized on the I-123 MIBG scintigrams in six out of eight patients.

  7. Three-dimensional Noninvasive Monitoring Iodine-131 Uptake in the Thyroid Using a Modified Cerenkov Luminescence Tomography Approach

    PubMed Central

    Qu, Xiaochao; Yang, Weidong; Liang, Jimin; Wang, Jing; Tian, Jie

    2012-01-01

    Background Cerenkov luminescence tomography (CLT) provides the three-dimensional (3D) radiopharmaceutical biodistribution in small living animals, which is vital to biomedical imaging. However, existing single-spectral and multispectral methods are not very efficient and effective at reconstructing the distribution of the radionuclide tracer. In this paper, we present a semi-quantitative Cerenkov radiation spectral characteristic-based source reconstruction method named the hybrid spectral CLT, to efficiently reconstruct the radionuclide tracer with both encouraging reconstruction results and less acquisition and image reconstruction time. Methodology/Principal Findings We constructed the implantation mouse model implanted with a 400 µCi Na131I radioactive source and the physiological mouse model received an intravenous tail injection of 400 µCi radiopharmaceutical Iodine-131 (I-131) to validate the performance of the hybrid spectral CLT and compared the reconstruction results, acquisition, and image reconstruction time with that of single-spectral and multispectral CLT. Furthermore, we performed 3D noninvasive monitoring of I-131 uptake in the thyroid and quantified I-131 uptake in vivo using hybrid spectral CLT. Results showed that the reconstruction based on the hybrid spectral CLT was more accurate in localization and quantification than using single-spectral CLT, and was more efficient in the in vivo experiment compared with multispectral CLT. Additionally, 3D visualization of longitudinal observations suggested that the reconstructed energy of I-131 uptake in the thyroid increased with acquisition time and there was a robust correlation between the reconstructed energy versus the gamma ray counts of I-131 (). The ex vivo biodistribution experiment further confirmed the I-131 uptake in the thyroid for hybrid spectral CLT. Conclusions/Significance Results indicated that hybrid spectral CLT could be potentially used for thyroid imaging to evaluate its function

  8. Higher cancer risk continues after Chernobyl

    Cancer.gov

    Nearly 25 years after the accident at the Chernobyl nuclear power plant in Ukraine, exposure to radioactive iodine-131(I-131, a radioactive isotope) from fallout may be responsible for thyroid cancers that are still occurring among people who lived in the Chernobyl area and were children or adolescents at the time of the accident, researchers say. An international team of researchers led by the NCI found a clear dose-response relationship, in which higher absorption of radiation from I-131 led to an increased risk for thyroid cancer that has not seemed to diminish over time.

  9. Artificial radionuclides in Russia due to the Fukushima NPP accident

    NASA Astrophysics Data System (ADS)

    Polianskaia, Olga; Vakulovsky, Sergey; Kim, Vera; Yahryushin, Valery; Volokitin, Andrey

    2013-04-01

    Radioactive emission into the atmosphere from the damaged reactors of the Fukushima Daiichi nuclear power plant (NPP) started on March 12th, 2011. The network of Federal Hydrometeorology and Environmental Monitoring Service (Rosgydromet) carries out supervision over a radiation situation on the territory of Russia. In Russia, the first radionuclides from Fukushima were detected on March 20th in the Far East by network. From March 20th to April 30th I-131 (particulate form), Cs-137 and Cs-134 were detected in samples of atmospheric aerosols at the 30 stations of networks and the same ones were detected in fallout at the 25 stations of networks. The first detection of I-131 in the European territory of Russia (ETR) occurred on March 23rd; and in the South and the North of Siberia - on March 26th. The volumetric activities of I-131 in the ETR sharply increased from March 28th to 30th. Along with the increasing content of I-131 cesium isotopes appeared in the air. The maximum values of radionuclides volume activity were observed between April 3rd and 4th: for I-131 - 4,0 mBq/m3, for Cs-137 - 1,15 mBq/m3, for Cs-134 - 1,04 mBq/m3. Observed in the Far East, the maximum values for I-131 were 2-4 times lower than in the ETR. The maximum values for I-131 in the Asian territory of Russia (ATR) were 2 - 8 times lower, than in the ETR. The Cs-137/Cs-134 ratio in samples of atmospheric aerosols was about 1. The ratio I-131/Cs-137 in air changed in a wide range. From March 23rd to April 5th the ratio fluctuated within 11 to 34, from April 5th to 20th of the ratio decreased and varied within 1,5 to 7,7, further it became less than 1. The value of cesium isotopes in second quarter of 2011 in fallout was lower than 2 Bq/m2. The addition to the density of soil contamination by Cs-137 by 2 to 3 orders of magnitude less than the decrease of the density of contamination with this isotope of the global origin due to radioactive decay. Based on the obtained experimental data we can

  10. Iodine-131 meta-iodobezylguanidine single photon emission computed tomography/computerized tomography in diagnosis of neuro-endocrine tumors

    PubMed Central

    Harisankar, Chidambaram Natrajan Balasubramanian; Mittal, Bhagwant Rai; Bhattacharya, Anish; Kashyap, Raghava; Bhansali, Anil

    2012-01-01

    Metaiodobenzyl guanidine (MIBG) is a derivative of guanethidine and acts as an analogue of nor-epinephrine and is widely used in the imaging of tumors of neuro-endocrine origin. Iodine-123 MIBG has ideal imaging characteristics but is expensive with limited availability. Iodine-131 MIBG is widely used in India and is cheap. Hybrid single photon emission computed tomography (SPECT)/computerized tomography (CT) allows for anatomico-functional imaging and is being tried in MIBG studies. However, the experience with I-131 MIBG is limited. We present a pictorial assay of I-131 MIBG SPECT/CT findings in various MIBG avid tumors. PMID:23599604

  11. Unusual locations of localized myxedema in Graves disease. Report of three cases

    SciTech Connect

    Noppakun, N.; Bancheun, K.; Chandraprasert, S.

    1986-01-01

    Three patients with Graves disease had very unusual locations of localized myxedema. One patient had localized myxedema on the pretibial and shoulder areas after sodium iodide I 131 therapy. The second patient had localized myxedema on his neck, shoulders, and upper part of the back as well as on the pretibial area. The third patient had localized myxedema on the pinnae, also following sodium iodide I 131 therapy. After surgical removal followed by intralesional triamcinolone acetonide injections, the first patient's lesions recurred. The lesions in the second case did not respond to topical steroid cream. The third patient had a partial response to intralesional steroid injections.

  12. Improvement of C peptide zero BMI 24-34 diabetic patients after tailored one anastomosis gastric bypass (BAGUA).

    PubMed

    Garciacaballero, M; Martínez-Moreno, J M; Toval, J A; Miralles, F; Mínguez, A; Osorio, D; Mata, J M; Reyes-Ortiz, A

    2013-03-01

    Introducción: Aunque la cirugía bariátrica ha demostrado ser un método muy eficaz en el tratamiento de pacientes diabéticos cuyo páncreas aún es capaz de producir insulina (diabetes tipo 2), así como del síndrome metabólico y las complicaciones relacionadas con la diabetes, no hay información sobre el efecto de este tipo de cirugía en pacientes IMC 24-34 cuando el páncreas no produce insulina en absoluto (tipo 1, tipo LADA y diabetes tipo 2 de larga evolución, entre otros). Métodos: Presentamos datos preliminares de una serie de 11 pacientes todos con valores de Péptido C < 0,0 ng/ml. El seguimiento postoperatorio varia de 6 y 60 meses (media 19 meses). Estudiamos los cambios en el control de la glucemia, evolución del síndrome metabólico y complicaciones relacionadas con la diabetes tras bypass de una anastomosis (BAGUA). Resultados: Mejoraron todos los valores relativos al control glucémico HbA1c (de 8,9 ± 0,6 a 6,7 ± 0,2%), FPG (Glucosa Plasmática Ayunas) (de 222,36 ± 16,87 a 94 ± 5 (mg/dl)) así como el requerimiento diario de insulina, tanto de insulina rápida (de 40,6 ± 12,8 a 0 U/día) como de insulina retardada (41,27 ± 7,3 U/día a 15,2 ± 3,3 U/día). Se resolvieron el 100% de las comorbilidades estudiadas y se mejoraron algunas complicaciones graves derivadas de la diabetes como retinopatía o nefropatía. Conclusiones: El bypass gástrico de una anastomosis adaptado a pacientes diabéticos IMC24-34 con péptido C cero elimina el uso de insulina de acción rápida, reduce a una sola inyección diaria la insulina retardada y mejora el control glucémico. Tras la cirugía desaparecen el síndrome metabólico y los episodios severos de hipoglucemia, y mejora significativamente la retinopatía, neuropatía, nefropatía, vasculopatía periférica y cardiopatía.

  13. [Eating habits, physical activity and socioeconomic level in university students of Chile].

    PubMed

    Rodríguez, Fernando; Palma, Ximen; Romo, Angela; Escobar, Daniela; Aragú, Bárbara; Espinoza, Luis; McMillan, Norman; Gálvez, Jorge

    2013-01-01

    Introducción: Los estudiantes universitarios son vulnerables a una mala nutrición, no consumen meriendas entre las comidas, no desayunan, ayunan por largas horas, prefieren la comida rápida y además no realizan ejercicios físicos. La población universitaria es considerada la población adulto joven clave para la promoción y prevención de salud para las futuras generaciones, por lo que es trascendental identificar la situación actual nutricional y la frecuencia de actividad física de los universitarios. Objetivos: Determinar los factores que intervienen en la elección de los alimentos y la frecuencia de actividad física en estudiantes universitarios. Métodos: Se evaluaron 799 voluntarios de cuatro universidades de la quinta región de Chile. Se aplicó un instrumento para determinar el nivel de actividad física y de hábitos alimentarios, el test kidmed para determinar la adherencia a la dieta mediterránea y un instrumento Adimark para determinar el nivel socioeconómico de los sujetos. Finalmente se realizó una evaluación antropométrica para determinar IMC, masa grasa y masa muscular. Resultados: La inactividad física es mayor en mujeres que en hombres y plantean que la principal razón para no hacer ejercicio es la falta de tiempo y la pereza. En ambos sexos no leen las etiquetas nutricionales y tienen una media adherencia a la dieta mediterránea. Discusión: Existen bajos conocimientos de nutrición que provocan una mala calidad en la alimentación de los sujetos y no existe motivación para realizar mayor actividad física. El nivel socioeconómico no tiene relación con los hábitos alimentarios ni con la actividad física, por lo que es necesario integrar programas regulares y permanentes de vida sana en todas las universidades.

  14. The Combine Project: An Experience in a Dual-Language Classroom = El proyecto de la cosechadora: una experiencia en una clase bilingue.

    ERIC Educational Resources Information Center

    Wilson, Rebecca

    This article, also available in Spanish, describes what happened when a bilingual kindergarten class in West Liberty, Iowa, investigated a combine. The dual-language Kindergarten program supports content area instruction in both Spanish and English. The first part of the article tells the story of the Combine Project, this class's first project…

  15. The Combine Project: An Experience in a Dual-Language Classroom = El proyecto de la cosechadora: una experiencia en una clase bilingue.

    ERIC Educational Resources Information Center

    Wilson, Rebecca

    This article, also available in Spanish, describes what happened when a bilingual kindergarten class in West Liberty, Iowa, investigated a combine. The dual-language Kindergarten program supports content area instruction in both Spanish and English. The first part of the article tells the story of the Combine Project, this class's first project…

  16. [Effects of diet and aerobic or anaerobic exercises on eating disorders].

    PubMed

    Martinez-Rodriguez, Alejandro

    2014-10-19

    Introducción: Actividades físicas de larga duración, con predominio aeróbico, requieren una práctica deportiva extensiva y continuada para obtener mejoras en el rendimiento. Mientras que las actividades anaeróbicas, requieren de un volumen de entrenamiento menor, aunque a intensidades más elevadas para alcanzar un buen estado de forma deportiva. La disminución del porcentaje graso dentro de la composición corporal, tanto de deportes aeróbicos como anaeróbicos, es una cuestión presente, sobretodo en estos último tiempos. Conseguir un adecuado estado nutricional, con estrategias inadecuadas, puede originar la aparición de trastornos de la conducta alimentaria. Objetivo: determinar las diferencias existentes entre dos grupos de deportistas en función de la práctica de deportes aeróbicos o anaeróbicos, en cuanto a la presencia de desórdenes alimentarios, adherencia a dieta baja en grasa y actividad física. Método: En este estudio participaron 206 sujetos varones entrenados que cumplimentaron los cuestionarios de actividad física en el tiempo libre de Minnesota abreviado, EAT-26 y Predimed de “Adherencia a dieta baja en grasa”. Resultados: Los deportistas que practican deportes aeróbicos muestran mayores puntuaciones en la mayoría de las subescalas y en el resultado total del cuestionario EAT-26. A mayor número de sesiones de práctica en deportes aeróbicos, aparecen puntuaciones superiores en el Control Oral. Dentro de esta población, el consumo de suplementos incrementa significativamente las puntuaciones del EAT-26 y la predisposición a un TCA, al igual que los planes de entrenamientos muy estrictos. Discusión: Los deportistas que practican deportes de corte más aeróbico parecen mostrar una mayor predisposición a la presencia de un TCA.

  17. [Onychomycosis frequency in psoriatic patients in a tertiary care hospital].

    PubMed

    Méndez-Tovar, Luis Javier; Arévalo-López, Alfredo; Domínguez-Aguilar, Sofía; Manzano-Gayosso, Patricia; Hernández-Hernández, Francisca; López Martínez, Rubén; Silva González, Israel

    2015-01-01

    Introducción: los cambios ungueales en los pacientes con psoriasis pueden ser muy parecidos a la onicomicosis y, por lo tanto, las infecciones fúngicas pueden ser subdiagnosticadas. Se investigó la frecuencia de onicomicosis en manos y pies de 150 pacientes con psoriasis de un servicio de dermatología. Métodos: se obtuvieron los datos clínicos de la psoriasis. Se cultivaron escamas de las uñas en agar dextrosa Sabouraud con y sin antibióticos y se hizo un examen directo con KOH. Resultados: de los 150 pacientes, 67 (45 %) presentaron uñas sanas; 42 (28 %) tuvieron onicomicosis, y 41 (27 %) onicopatía sin infección. Las alteraciones ungueales en las manos estuvieron más asociadas con onicopatía psoriásica (82.5 %); los cambios de las uñas de los pies se asociaron más frecuentemente a infección fúngica (26.4 frente a 9.45 % en psoriasis). De 20 cultivos positivos, se aislaron 22 agentes: 11 Candida spp. (50 %). Como factor de riesgo para desarrollar onicomicosis, el tiempo de evolución de la psoriasis mostró una diferencia significativa (p = 0.03). Conclusión: en los pacientes con psoriasis, las alteraciones ungueales de manos se deben principalmente a psoriasis, mientras que los cambios ungueales en los pies se asocian a onicomicosis. Esta fue causada principalmente por Candida sp. El único factor de riesgo asociado para onicomicosis fue la larga evolución de la psoriasis.

  18. Mecanismos cinéticos y distribuciones energéticas de iones (H3+, N2H+, CH3+...) en plasmas fríos de H2/N2/CH4

    NASA Astrophysics Data System (ADS)

    Tanarro, I.; Herrero, V. J.; Islyaikin, A.; Tabarés, F. L.; Tafalla, D.

    En este trabajo se presenta el estudio espectrométrico de los plasmas levemente ionizados generados en una descarga continua a baja presión de H2 con trazas de N2 y CH4, orientado principalmente a identificar la naturaleza y distribución energética de los iones que en ella se producen, y a asignar algunos de los mecanismos cinéticos elementales de formación y destrucción de tales especies. Alguno de los iones mayoritarios de estos plasmas, como el H3+, presenta gran interés desde el punto de vista de la Astrofísica por su prevista intervención en la química de las ionosferas planetarias y del medio interestelar, al actuar como sustancia intermedia en la formación de gran variedad de especies moleculares; si bien, dada su pequeña concentración, su observación real en el espacio se demoró hasta la pasada década de los años 90, cuando fue detectado por primera vez en la atmósfera de Júpiter y en otros objetos estelares. Del mismo modo que los trabajos espectroscópicos de laboratorio resultan indispensables para la posterior identificación de las especies observadas en el espacio, es de esperar que la asignación de los procesos cinéticos más importantes que tienen lugar en los plasmas generados en reactores de descarga, como los aquí presentados, permitan extrapolar los resultados así obtenidos al esclarecimiento de los mecanismos fisico-químicos participantes en otros medios observables únicamente a larga distancia.

  19. El Sistema de Referencia Celeste convencional de la IAU

    NASA Astrophysics Data System (ADS)

    Arias, E. F.

    La Unión Astronómica Internacional (IAU) recomendó la adopción de un nuevo sistema de referencia celeste baricéntrico cuyo plano fundamental y origen de ascensiones rectas estén próximos, respectivamente, al ecuador y equinoccio dinámicos J2000.0. El nuevo sistema de referencia estará materializado por las posiciones J2000.0 de radiofuentes extragalácticas determinadas con la técnica de interferometría de larga línea de base (VLBI). El Working Group on Reference Frames de la IAU (WGRF) decidió adoptar (Grasse, 1995) al sistema de referencia celeste extragaláctico del Servicio Internacional de la Rotación Terrestre (IERS) como futuro sistema de referencia celeste convencional bajo el nombre International Celestial Reference System (ICRS) y encomendó su mantenimiento futuro al IERS. El marco de referencia que materializará al ICRS contiene posiciones precisas J2000.0 de más de 600 radiofuentes extragalácticas. Las coordenadas fueron ajustadas en una única solución VLBI en la cual se incluyeron todas las observaciones realizadas hasta octubre de 1995 con la técnica de adquisición de datos VLBI Mark III. Para minimizar los errores sistemáticos que pueden afectar la calidad del marco de referencia se introdujeron mejoras sustanciales en la modelización y en la selección de datos. Un subconjunto de objetos del marco de referencia se utilizó para referir las posiciones estelares determinadas con el satélite astrométrico Hipparcos al ICRS.

  20. Análisis del futuro marco de referencia internacional

    NASA Astrophysics Data System (ADS)

    Cionco, G. R.; Arias, E. F.

    La técnica de interferometría de muy larga línea de base (VLBI) se aplica hoy a la astrometría para el cálculo de posiciones precisas de radiofuentes extragalácticas. Por tratarse de objetos lejanos, sus movimientos propios aparentes pueden considerarse nulos; esta propiedad hace que los catálogos de radiofuentes extragalácticas VLBI constituyan la mejor materialización de un sistema de referencia celeste inercial definido cinemáticamente. La Unión Astronómica Internacional (IAU) recomendó la adopción de un nuevo sistema de referencia celeste internacional materializado por las coordenadas ecuatoriales de objetos extragalácticos observados con le técnica VLBI. Para superar la precisión astrométrica actual es necesaria una mejora en la modelización de aquellos fenómenos que pueden introducir desviaciones sistemáticas en el marco de referencia celeste. El objetivo de este trabajo es poner de manifiesto las sistematicidades presentes en los distintos marcos de referencia elaborados con el próposito de materializar el nuevo sistema de referencia celeste de la IAU. Para la comparación de los distintos marcos de referencia se propone un modelo de tres rotaciones diferenciales más un término lineal que procura absorber los efectos sistemáticos presentes en las coordenadas. Se analiza igualmente la estabilidad de la solución cuando se utilizan distintos conjuntos de objetos de definición.

  1. Total number of planetary nebulae in different galaxies and the PN distance scale.

    NASA Astrophysics Data System (ADS)

    Peimbert, M.

    1990-12-01

    RESUMEN A partir de una muestra de quince galaxias se encuentra que la tasa de natalidad de nebulosas planetarias por unidad de luminosidad, , disminuye al aumentar la luminosidad y al aumentar (B - V)0. Se discuten posibles explicaciones para estos resultados. Se estima el valor de para la Galaxia y a partir de el se encuentra que el numero total de nebulosas planetarias en nuestra galaxia con R < 0.64 pc- es de 7200 j 1800. El valor galactico de implica que la mayorfa de las estrellas de masa intermedia pasa por la etapa de nebulosa planetaria. El valor galactico de , la tasa de mortalidad estelar por unidad de luminosidad y la tasa de natalidad de enanas blancas favorecen escalas de distancias largas para nebulosas planetarias, como la de Cudworth (1974) y la de Mallik y Peimbert (1988). ABSTRACT From a sample of fifteen galaxies it is found that the birth rate of PN per unit luminosity, , decreases with increasing luminosity and with increasing (B - V)0 possible reasons for these relationships are discussed. The value for the Galaxy is estimated and, from it, a total number of PN of 7200 # 1800 wid R < 0.64 pc is obtained. The galactic value implies that most of the intermediate mass stars go through the PN stage. The galactic value, the stellar death rate per unit luminosity and the white dwarf birth rate are in favor of long distance scales to PN like those of Cudworth (1974) and Mallik and (1988). Key wonis: NEBULAE.PLANETARY - STARS-EVOLUTION - STARS-SThLIAR STA. S

  2. Thyroid neoplasia risk is increased nearly 30 years after the Chernobyl accident.

    PubMed

    Tronko, Mykola; Brenner, Alina V; Bogdanova, Tetiana; Shpak, Victor; Oliynyk, Valeriy; Cahoon, Elizabeth K; Drozdovitch, Vladimir; Little, Mark P; Tereshchenko, Valeriy; Zamotayeva, Galyna; Terekhova, Galyna; Zurnadzhi, Lyudmila; Hatch, Maureen; Mabuchi, Kiyohiko

    2017-10-15

    To evaluate risk of thyroid neoplasia nearly 30 years following exposure to radioactive iodine (I-131) from the 1986 Chernobyl nuclear accident, we conducted a fifth cycle of thyroid screening of the Ukrainian-American cohort during 2012-2015, following four previous screening cycles started in 1998. We identified 47 thyroid cancers (TC) and 33 follicular adenomas (FA) among 10,073 individuals who were <18 years at the time of the accident and had a mean I-131 dose of 0.62 Gy. We found a significant I-131 dose response for both TC and FA, with an excess odd ratio per Gy of 1.36 (95% CI: 0.39-4.15) and 2.03 (95% CI: 0.55-6.69), respectively. The excess risk of malignant and benign thyroid neoplasia persists nearly three decades after exposure and underscores the importance of continued follow-up of this cohort to characterize long-term pattern of I-131 risk. © 2017 UICC.

  3. Identifying removable radioactivity on the surface of cats during the first week after treatment with iodine 131.

    PubMed

    Chalmers, H J; Scrivani, Peter V; Dykes, Nathan L; Erb, Hollis N; Hobbs, J M; Hubble, Lorna J

    2006-01-01

    Because radioiodine (1-131) is excreted in urine and saliva, treated cats can accumulate I-131 on their coats from contacting soiled litter and grooming. This could result in removable radioactivity, which is a potential source of human exposure to radiation and specifically to internal contamination. The purpose of this study was to determine if there is removable radioactivity on cats treated with I-131. Daily wipe tests were performed for 7 days at two sites (both flanks, one site; and all four paws, one site) on six hyperthyroid cats treated with I-131. A y counter was used to determine the counts per minute (cpm) of the samples, which were converted to disintegrations per minute (dpm) to estimate activity. The results were compared to the New York State limits of removable activity for a non-controlled area (<1000dpm/100 cm2) to determine if the amount of removable activity was acceptable for a member of the public. The median value of removable activity was 241 dpm (range from 34 to 4184 dpm) for the flanks, and 308 dpm (range from 60 to 1890 dpm) for the paws. The amount of removable radioactivity on the surface of hospitalized cats treated with I-131 during the first week after treatment, occasionally and without obvious pattern, exceeded the New York State limit. Sporadic activity as high as 4148 dpm was found. It is prudent to advise owners to observe routine hygiene when handling cats after discharge to minimize the risk of internal contamination.

  4. 75 FR 69851 - U.S. Citizenship and Immigration Services Fee Schedule; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-16

    ... refugee travel document for an adult age 16 or older should match the fee charged for the issuance of a... refugee travel document to $135 for an adult age 16 or older. The final rule inadvertently listed a fee of $165 for filing an Application for Travel Document, Form I-131, for a refugee travel document for an...

  5. Effect of prolonged hypokinesia on tissue blood flow

    NASA Technical Reports Server (NTRS)

    Levites, Z. P.; Fedotova, V. F.

    1979-01-01

    The influence of hypokinesia on the blood flow in the tissues of rabbits was studied. Motor activity of animals was restricted during 90 days and blood flow recorded through resorption rate of NaI-131. Perfusion of tissues under the influence of hypokinesia was found to be reduced.

  6. In vivo detection of prostatic carcinoma with antibodies against prostatic acid phosphatase

    SciTech Connect

    De Land, F.H.; Goldenberg, D.M.

    1984-01-01

    Serum prostatic acid phosphates (PAP) immunoassay is used to evaluate patients with prostatic carcinoma; however, as with other tumor markers, the enzyme levels do not necessarily reflect the presence or extent of tumor. The authors investigated the use of radiolabeled PAP antibodies for the in vivo detection of prostatic carcinoma by external scintillation imaging. Nine patients with prostatic carcinoma were entered into the study. Each received from 2.0 to 2.5 mCi of I-131 labeled antibody to PAP, administered i.v. The immunogen (PAP) was purified from normal human seminal fluid. Antiserum was prepared in rabbits by injecting the purified PAP. The antibodies were labeled with I-131 by chloramine-T method (10 to 20 Ci/g of IgG). Total body images were obtained at 24 and 48 hrs following administration of the labeled antibody. Nontarget I-131 activity was diminished by computer processing. Tumor sites detected by I-131 antibodies were correlated with other diagnostic procedures. In 7 of 9 patients primary and metastatic sites of cancer were detected by antibody imaging, however, no bone lesions were detected (6 cases). In 3 patients with concomitant pulmonary tumors, one was identified as of prostate origin. The serum PAP was normal in 4 patients; however, the primary tumor was identified in 3 of these. These findings suggest that the localization of prostatic carcinoma by means of in-vivo imaging of labeled antibodies to PAP is feasible and offers diagnostic opportunities based upon the functional characteristics.

  7. 8 CFR 245a.35 - Travel outside the United States.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Travel outside the United States. 245a.35... outside the United States. (a) An alien who departs the United States while his or her application for... travel outside the United States temporarily must apply for advance authorization using Form I-131....

  8. 10 CFR Appendix D to Part 835 - Surface Contamination Values

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... + Removable) 2,3 U-nat, U-235, U-238, and associated decay products 7 1,000 7 5,000 Transuranics, Ra-226, Ra..., I-126, I-131, I-133 200 1,000 Beta-gamma emitters (nuclides with decay modes other than alpha... to radioactive contamination deposited on, but not incorporated into the interior or matrix of,...

  9. 10 CFR Appendix D to Part 835 - Surface Contamination Values

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... + Removable) 2 3 U-nat, U-235, U-238, and associated decay products 7 1,000 7 5,000 Transuranics, Ra-226, Ra..., I-126, I-131, I-133 200 1,000 Beta-gamma emitters (nuclides with decay modes other than alpha... to radioactive contamination deposited on, but not incorporated into the interior or matrix of,...

  10. 10 CFR Appendix D to Part 835 - Surface Contamination Values

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... + Removable) 2,3 U-nat, U-235, U-238, and associated decay products 7 1,000 7 5,000 Transuranics, Ra-226, Ra..., I-126, I-131, I-133 200 1,000 Beta-gamma emitters (nuclides with decay modes other than alpha... to radioactive contamination deposited on, but not incorporated into the interior or matrix of,...

  11. 10 CFR Appendix D to Part 835 - Surface Contamination Values

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... + Removable) 2,3 U-nat, U-235, U-238, and associated decay products 7 1,000 7 5,000 Transuranics, Ra-226, Ra..., I-126, I-131, I-133 200 1,000 Beta-gamma emitters (nuclides with decay modes other than alpha... to radioactive contamination deposited on, but not incorporated into the interior or matrix of,...

  12. 10 CFR Appendix D to Part 835 - Surface Contamination Values

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... + Removable) 2,3 U-nat, U-235, U-238, and associated decay products 7 1,000 7 5,000 Transuranics, Ra-226, Ra..., I-126, I-131, I-133 200 1,000 Beta-gamma emitters (nuclides with decay modes other than alpha... to radioactive contamination deposited on, but not incorporated into the interior or matrix of,...

  13. SU-E-I-78: Establishing a Protocol for Quick Estimation of Thyroid Internal Contamination with 131I in Normal and Emergency Situations

    SciTech Connect

    Naderi, S Mehdizadeh; Karimipourfard, M; Lotfalizadeh, F; Zamani, E; Molaeimanesh, Z; Sadeghi, M; Sina, S; Faghihi, R; Entezarmahdi, M

    2015-06-15

    Purpose: I-131 is one of the most frequent radionuclides used in nuclear medicine departments. The radiation workers, who manipulate the unsealed radio-toxic iodine, should be monitored for internal contamination. In this study a protocol was established for estimating I-131 activity absorbed in the thyroid glands of the nuclear medicine staff in normal working condition and also in accidents. Methods: I-131 with the activity of 10 μCi was injected inside the thyroid gland of a home-made anthropomorphic neck phantom. The phantom is made up of PMMA as soft tissue, and Aluminium as bone. The dose rate at different distances from the surface of the neck phantom was measured using a scintillator detector for duration of two months. Then, calibration factors were obtained, for converting the dose rate at each distance to the iodine activity inside the thyroid. Results: According to the results of this study, the calibration factors for converting the dose rates (nSv/h) at distances of 0cm, 1cm, 6cm, 11cm, and 16cm to the activity (kBq) inside the thyroid were found to be 0.03, 0.04, 0.14, 0.29, and 0.49 . Conclusion: This method can be effectively used for quick estimation of the I-131 concentration inside the thyroid of the staff for daily checks in normal working conditions and also in accidents.

  14. Changing implications of renal non-visualization in azotemia

    SciTech Connect

    Zuckier, L.S.; Axelrod, M.S.; Wexler, J.P.; Heller, S.L.; Davis, L.P.; Milstein, D.M.; Chun, K.J.; Blaufox, M.D.

    1985-05-01

    It has been reported that poorly functioning kidneys are better imaged with I-131 Hippuran than Tc-99m DTPA. Recently 2 pts have been observed with non-visualization of the kidney on Hippuran imaging (serum creatinine 17.7 and 18.9 mg/dl) and 1 with poor visualization (serum creatinine 8.1 mg/dl) whose kidneys were well visualized with Tc-99m DTPA imaging. The inability to image these kidneys with Hippuran may be due to decreased I-131 resolution in newer gamma cameras. Imaging of I-131 and Tc-99m on old (8 yr) and new cameras was systematically studied using a kidney-body phantom and 7 kidney to background ratios (100/1 to 1.51/1), and 7 different count rates (lk to 100k). At low count rates, the I-131 phantom was more consistently identified by a blinded observer on the older camera images. This phenomenon was not detected at higher count rates. These data suggest that renal non-visualization with Hippuran on modern camera may not imply the same level of renal insufficiency as it did on older systems. Furthermore, the presence of a well defined kidney on DTPA imaging may suggest better renal function than is present.

  15. Castleman disease mimicking nodal recurrence of thyroid cancer.

    PubMed

    Zeng, Yi-Hong; Chen, Chi-Kuan; Lee, Chun-Chuan

    2016-02-01

    A 54-year-old woman who had undergone total thyroidectomy and radioactive iodine treatment for papillary thyroid cancer presented with elevated stimulated thyroglobulin levels and negative I-131 scan. Ultrasonography revealed suspicious lateral neck lymph nodes, which were FDG-avid. Neck dissection led to a diagnosis of Castleman disease.

  16. 8 CFR 245a.35 - Travel outside the United States.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Travel outside the United States. 245a.35... OF THE IMMIGRATION AND NATIONALITY ACT LIFE Act Amendments Family Unity Provisions § 245a.35 Travel... travel outside the United States temporarily must apply for advance authorization using Form I-131....

  17. 8 CFR 245a.35 - Travel outside the United States.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Travel outside the United States. 245a.35... OF THE IMMIGRATION AND NATIONALITY ACT LIFE Act Amendments Family Unity Provisions § 245a.35 Travel... travel outside the United States temporarily must apply for advance authorization using Form I-131....

  18. A large substernal goiter as a cause of a pulmonary perfusion defect

    SciTech Connect

    Balon, H.R.; Meier, D.A. )

    1990-11-01

    A pulmonary perfusion defect was caused by an extremely large anterior mediastinal mass subsequently proved by I-131 imaging to be an intrathoracic extension of a cervical goiter. Substernal goiter is not known to be reported previously as one of the causes of a perfusion defect in lung scanning.

  19. Analysis of Radionuclide Releases from the Fukushima Dai-ichi Nuclear Power Plant Accident Part II

    NASA Astrophysics Data System (ADS)

    Achim, Pascal; Monfort, Marguerite; Le Petit, Gilbert; Gross, Philippe; Douysset, Guilhem; Taffary, Thomas; Blanchard, Xavier; Moulin, Christophe

    2014-03-01

    The present part of the publication (Part II) deals with long range dispersion of radionuclides emitted into the atmosphere during the Fukushima Dai-ichi accident that occurred after the March 11, 2011 tsunami. The first part (Part I) is dedicated to the accident features relying on radionuclide detections performed by monitoring stations of the Comprehensive Nuclear Test Ban Treaty Organization network. In this study, the emissions of the three fission products Cs-137, I-131 and Xe-133 are investigated. Regarding Xe-133, the total release is estimated to be of the order of 6 × 1018 Bq emitted during the explosions of units 1, 2 and 3. The total source term estimated gives a fraction of core inventory of about 8 × 1018 Bq at the time of reactors shutdown. This result suggests that at least 80 % of the core inventory has been released into the atmosphere and indicates a broad meltdown of reactor cores. Total atmospheric releases of Cs-137 and I-131 aerosols are estimated to be 1016 and 1017 Bq, respectively. By neglecting gas/particulate conversion phenomena, the total release of I-131 (gas + aerosol) could be estimated to be 4 × 1017 Bq. Atmospheric transport simulations suggest that the main air emissions have occurred during the events of March 14, 2011 (UTC) and that no major release occurred after March 23. The radioactivity emitted into the atmosphere could represent 10 % of the Chernobyl accident releases for I-131 and Cs-137.

  20. In Utero Exposure to Iodine-131 from Chernobyl Fallout and Anthropometric Characteristics in Adolescence

    PubMed Central

    Neta, Gila; Hatch, Maureen; Kitahara, Cari M.; Ostroumova, Evgenia; Bolshova, Elena V.; Tereschenko, Valery P.; Tronko, Mykola D.; Brenner, Alina V.

    2014-01-01

    Prenatal exposure to external radiation has been linked to growth retardation among atomic bomb survivors in adolescence. It is unclear from previous studies whether in utero exposure to internal radiation such as iodine-131 (I-131), which concentrates in the thyroid gland, has an effect on physical growth. We examined the associations between estimated thyroid gland dose from prenatal exposure to I-131 and self-reported height and weight in a cohort of 2,460 individuals exposed to radioactive fallout from the 1986 Chernobyl nuclear accident [mean I-131 dose = 72 (mGy)] and screened for thyroid diseases in adolescence. Using multivariable linear regression models, we estimated the mean differences in height, weight and body mass index (BMI) per unit increase in dose (100 mGy) in models adjusted for gender, age at examination, type of residence (rural/urban) and presence of thyroid disease diagnosed at screening. All of the adjustment factors as well as the trimester of exposure were evaluated as potential modifiers of the dose response. Overall, no significant dose response was found for height (P = 0.29), weight (P = 0.14) or BMI (P = 0.16). We found significant modification of the dose response for weight and BMI by presence/absence of thyroid disease (P = 0.02 and P = 0.03, respectively), but not for other factors. In individuals without thyroid disease (n = 1,856), there was a weak, significant association between I-131 thyroid dose and higher weight (210 g per 100 mGy, P = 0.02) or BMI (70 g/m2 per 100 mGy, P = 0.02) that depended on individuals (n = 52) exposed to ≥500 mGy. In individuals with thyroid disease (n = 579, 67.4% with simple diffuse goiter) no significant association with I-131 for weight (P = 0.14) or BMI (P = 0.14) was found. These results do not support the hypothesis that in utero exposure to I-131 at levels experienced by a majority of study subjects may be associated with meaningful differences in adolescent anthropometry. However

  1. Nuclear medicine program progress report for quarter ending March 31, 1996

    SciTech Connect

    Knapp, F.F. Jr.; Ambrose, K.R.; Beets, A.L.; Guhlke, S.; Luo, H.; McPherson, D.W.; Mirzadeh, S.; Mokler, F.

    1996-10-01

    Biodistribution studies with the radioiodinated 3(R)- and 3(S)-BMIPP isomers in rats have shown that 3(R)-BMIPP has 20-25% higher heart uptake (15-180 min) than 3(S)-BMIPP, while uptake in other tissues examined is similar. To evaluate the possible differences in metabolic fate of the two isomers, a mixture of [I-125]-3(R)/[I-131]- 3(S)-BMIPP was administered to fasted female Fisher rats. Groups (n=3 rats per group) were sacrificed after 15, 60 and 180 min, and urine and feces collected from another group. Samples of blood, heart, liver, lungs, kidney, and urine were Folch-extracted. The distribution of I-125 and I-131 in the organic, aqueous, and pellet samples were determined. Organic samples were then analyzed by thin-layer chromatography (TLC) and high performance liquid chromatography (HPLC). The relative distribution of I-125/I-131 in the lipid, aqueous, and pellet samples was similar for both isomers. Distribution of I-125/I-131 in the various components of the lipid extracts observed by TLC was similar, with principal incorporation into the free fatty acid (FFA) and triglyceride (TG) pools. HPLC analyses (Cl8) of the FFA fraction showed similar I-125/I-131 profiles, corresponding to BMIPP, and the {alpha}-methyl-C,4 (PIPA) and C12, Cl0 and C6 carbon chain-length catabolites. By TLC, urine I-125/I-131 chromatographed with hippuric acid. HPLC analyses (Cl 8) of acid-hydrolyzed urine gave a single I-125/I-131 component with the same RRT as 2-({beta}-iodophenyl)acetic acid, the final {alpha}/{beta}-oxidative BMIPP catabolite. Unexpectedly, HPLC of lipids from base hydrolyzed TG from the heart tissue, showed I-125/I-125 co-chromatographing with short-chain fatty acids, with only levels in BMIPP. These unexpected results demonstrate that the 3(R)-BMIPP and 3(S)-BMIPP isomers are metabolized similarly in rat tissues, and that the higher myocardial extraction observed for the 3(R)-BMIPP may reflect differences in the relative membrane transport of the two isomers.

  2. PubMed

    Ocón Bretón, Maria Julia; Ilundain Gonzalez, Ana Isabel; Altemir Trallero, Jara; Agudo Tabuenca, Ana; Gimeno Orna, José Antonio

    2017-06-05

    Introducción:la nutrición parenteral total (NPT) es una modalidad de soporte nutricional indicada en aquellas situaciones donde el enfermo no puede cubrir sus requerimientos nutricionales por vía enteral. A pesar de ser una terapia segura y efi caz, no está exenta de complicaciones, entre las que cabe destacar, por su frecuencia, la hipertrigliceridemia. La etiología de esta complicación metabólica es compleja y multifactorial.Objetivos: el objetivo de este trabajo fue determinar los factores de riesgo asociados al desarrollo de hipertrigliceridemia en pacientes adultos hospitalizados no críticos que reciben NPT a corto plazo y evaluar el efecto que una emulsión lipídica enriquecida en ácidos grasos poliinsaturados omega-3 ejerce sobre esta complicación metabólica. Material y métodos: estudio observacional retrospectivo de cohortes donde se ha incluido a pacientes hospitalizados adultos no críticos que precisaron NPT durante un periodo superior a siete días. Se consideró la presencia de hipertrigliceridemia cuando los niveles plasmáticos de triglicéridos fueron superiores a 200 mg/dl. Las emulsiones lipídicas empleadas fueron una mezcla al 50% de triglicéridos de cadena larga (LCT) y de cadena media (MCT) o una combinación al 40% LCT/50% MCT/10% omega-3. Se recogieron variables clínicas, nutricionales y bioquímicas. Las determinaciones analíticas se realizaron antes del comienzo de la NPT y semanalmente hasta su retirada. Los factores predictores de la aparición de hipertrigliceridemia fueron identifi cados mediante modelos de regresión logística multivariante.Resultados: fueron incluidos 101 pacientes (61,4% varones), de los cuales el 33% desarrolló hipertrigliceridemia. En el análisis multivariante los factores de riesgo independientes asociados a la presencia de hipertrigliceridemia fueron los niveles plasmáticos iniciales de triglicéridos, el índice de masa corporal (IMC) y un aporte de glucosa en la NPT superior a 3,1 g

  3. A Screening Study of Thyroid Cancer and Other Thyroid Diseases among Individuals Exposed in Utero to Iodine-131 from Chernobyl Fallout

    PubMed Central

    Hatch, M.; Brenner, A.; Bogdanova, T.; Derevyanko, A.; Kuptsova, N.; Likhtarev, I.; Bouville, A.; Tereshchenko, V.; Kovgan, L.; Shpak, V.; Ostroumova, E.; Greenebaum, E.; Zablotska, L.; Ron, E.; Tronko, M.

    2009-01-01

    Background: Like stable iodine, radioiodines concentrate in the thyroid gland, increasing thyroid cancer risk in exposed children. Data on exposure to the embryonic/fetal thyroid are rare, raising questions about use of iodine 131 (I-131) in pregnant women. We present here estimated risks of thyroid disease from exposure in utero to I-131 fallout from the Chernobyl nuclear accident. Methods: We conducted a cross-sectional thyroid screening study (palpation, ultrasound, thyroid hormones, and, if indicated, fine needle aspiration) from 2003 to 2006. Participants were 2582 mother-child pairs from Ukraine in which the mother had been pregnant at the time of the accident on April 26, 1986, or 2 months after the time during which I-131 fallout was still present (1494 from contaminated areas, 1088 in the comparison group). Individual cumulative in utero thyroid dose estimates were derived from estimated I-131 activity in the mother’s thyroid (mean 72 mGy; range 0–3230 mGy). Results: There were seven cases of thyroid carcinoma and one case of Hurthle cell neoplasm identified as a result of the screening. Whereas the estimated excess odds ratio per gray for thyroid carcinoma was elevated (excess odds ratio per gray 11.66), it was not statistically significant (P = 0.12). No radiation risks were identified for other thyroid diseases. Conclusion: Our results suggest that in utero exposure to radioiodines may have increased the risk of thyroid carcinoma approximately 20 yr after the Chernobyl accident, supporting a conservative approach to medical uses of I-131 during pregnancy. PMID:19106267

  4. Radioimmunoimaging of osteogenic sarcoma xenografts in nude mice using monoclonal antibodies to osteogenic sarcoma

    SciTech Connect

    Sakahara, H.; Endo, K.; Nakashima, T.; Koizumi, M.; Ohta, H.; Kunimatsu, M.; Torizuka, K.; Nakamura, T.; Tanaka, H.; Kotoura, Y.

    1985-05-01

    The authors have developed several monoclonal antibodies against human osteogenic sarcoma, one of which; OST7 (IgGl) selectively localized in osteogenic sarcoma xenografts in nude mice. In the present study, F(ab')/sub 2/ fragment was compared with whole IgG and those labeled with In-111 as well as I-131 were used as a radiotracer for the scintigraphic imaging of tumors. IgC and F(ab')/sub 2/ were labeled with I-131 using chloramine-T method and injected into nude mice bearing human osteogenic sarcoma. Scintigrams at day 2 clearly delineated the site of tumors with almost no radioactivity in other organs with F(ab')/sub 2/, which yielded much better images than whole IgG. Tumor-to-blood ratio of 6.09-27.87 was obtained at day 2 using F(ab')/sub 2/, whereas it was 0.76-1.12 at day 2 and 2.05-3.27 at day 7 with IgG. I-131 labeled nonspecific F(ab')/sub 2/ or IgG resulted in no or very low tumor uptake with tumor-to-blood ratio of 0.94-1.18 at day 2 for F(ab')/sub 2/ and 0.67-0.76 at day 7 for IgG, respectively. In-111 labeled F(ab')/sub 2/ fragment of OST7, which was prepared using DTPA as a bifunctional chelate, also showed a high tumor accumulation with tumor-to-blood ratio of 11.67-17.54 at day 2, but higher background activity in the liver and kidney was observed than I-131 labeled one. These results indicate that F(ab')/sub 2/ fragment of OST7 labeled with either I-131 or In-111, has a great potential for the radioimmunoimaging of osteogenic sarcoma.

  5. Spatial Distributions of Iodine-131 and the Geochemical "Fingerprint" from the World Trade Center Terrorist Attack in New York Harbor Sediments

    NASA Astrophysics Data System (ADS)

    Oktay, S. D.; Smith, J. P.; Brabander, D. J.; Kada, J.; Olsen, C. R.

    2002-12-01

    The September 11, 2001 terrorist attack on the World Trade Center (WTC) in New York City introduced large amounts of ash and debris over an extensive area including New York Harbor (NYH) and the Lower Hudson Estuary. Previous results have identified a textural and elemental "fingerprint" for this ash/debris that can be seen as a quantifiable event horizon in NYH surface sediments. In addition, the short-lived radioisotope, I-131 (half-life, 8.04 days), was unexpectedly identified in the surface sediments, which corroborated that this sediment was recently deposited and anthropogenically influenced. On July 24-25, 2002, additional sediment cores were collected in the sites occupied in 2001 and in various locations throughout NYH (on both the Manhattan and New Jersey sides of the Hudson river) in order to determine the spatial extent of both the WTC "fingerprint" and the I-131 signal. Gamma spectrometric measurements of I-131 in surface sediments were used to determine its spatial distribution in NYH sediments and its potential use as an indicator of rapid sedimentary processes (days to weeks) initiated by urban input. Potential sources for the I-131 were evaluated, with initial evidence pointing to traces of human waste discharge related to medical treatments as the most likely source. The short-lived radionuclide, Be-7 (half-life, 53.12 days), and textural and elemental characterizations originally identified in the earlier research were examined in order to document the spatial distribution of the geochemical WTC "fingerprint" and investigate how short-to-medium term sediment dynamics (supply, deposition, re-suspension, and net accumulation) in New York Harbor may affect the spatial distribution and preservation of a sedimentological record associated with this event. This research should help delineate the geographical extent of the debris created from the WTC catastrophe and may predict where urban inputs of material such as I-131 can accumulate in NYH.

  6. Per una didattica con il laboratorio linguistico (Teaching with the Language Laboratory)

    ERIC Educational Resources Information Center

    Freddi, Giovanni

    1977-01-01

    Maintains that the language laboratory is the best way to aid language students in developing linguistic competence. The laboratory equipment needed is described and a pedagogical program for its effective use is outlined. (Text is in Italian.) (CFM)

  7. Una experiencia europea de innovacion pedagogica basada en la escritura de un ibro.

    ERIC Educational Resources Information Center

    Montane, Mireia; Roc, Merce

    2002-01-01

    Describes a European project based on writing a book from an educational perspective. Participants included 18 schools from 13 countries. The study originated in a Spanish Comenius 3.1 project, which determined that university teams would visit "book writing" schools, supporting teachers and analyzing and publishing their experiences.…

  8. Evolución de una protuberancia observada por el HASTA

    NASA Astrophysics Data System (ADS)

    Luoni, M. L.; Francile, C.

    Prominence eruptions are one of the most spectacular manifestations of solar activity; in addition to flares and coronal mass ejections. Both filaments and prominences are chromospheric material suspended in the corona by the magnetic field. Hence their importance as tracers of field ejections. Some parts of their magnetic structure are not well understood; especially with regard to the loss of stability. On 06 December 2010 the H-Alpha Telescope for Argentina (HASTA) observed a prominence in the eastern solar limb including when part of it was ejected. In this paper the evolution of the filament is analyzed; its structure before and after the eruption; determining parameters that characterize it from HASTA data. FULL TEXT IN SPANISH

  9. Habitos Alimentarios e Higiene Dental en una Poblacion Preescolar de Madrid.

    ERIC Educational Resources Information Center

    Lafarga, R. Tarazona; And Others

    1991-01-01

    Nutriment habits and oral hygiene in a preschool population in Madrid were studied by stratification in public or private schools. Significant differences were found only with regard to consumption of fish. Vegetable and fruit consumption was low in both groups, but not statistically significant. (SH)

  10. Como escoger una escuela para su hijo (Choosing a School for Your Child).

    ERIC Educational Resources Information Center

    Weston, Susan Perkins

    Step-by-step advice for Spanish-speaking parents on how to choose among available schools for their children is offered in this guidebook. Factors to consider in making the choice are discussed, as well as information on alternatives to the available choices, which include home schooling and working to create new options. After an introductory…

  11. Luchando por una educacion: A Qualitative Understanding of Undocumented Latina/o College Student Motivation

    ERIC Educational Resources Information Center

    Navarro, Elvia Lorena

    2013-01-01

    The current qualitative study explored the factors and resources that motivate undocumented Latino/a college students to persist in higher education. Through the data obtained from the four qualitative open-ended survey questions, a content analysis revealed specific codes, themes, and subthemes addressing the factors and resources that motivate…

  12. Community Resources Guide for Central Florida = Una Guia de Recursos en la Comunidad de Florida Central.

    ERIC Educational Resources Information Center

    Medina, Linda, Comp.

    Designed to orient Hispanic refugees to the services that are available in Central Florida, this bilingual guide consists of a section of general information on living and working in the United States and a section devoted to various public and private agencies. Provided first are addresses and phone numbers of various government agencies:…

  13. Predatory journals: una amenaza emergente para autores y editores de publicaciones biomédicas.

    PubMed

    Delgado-López, Pedro David; Corrales-García, Eva María

    2017-09-28

    So-called predatory publishing is a new and rising phenomenon presenting as an intellectual fraud that jeopardises the quality of scientific contribution, compromises the activity of authors, reviewers and editors of legitimate journals, damages the image of open access publications and is a very profitable business. In this paper, we review the concept and relevance of predatory journals and the characteristics that differentiate them from legitimate publications. Neurosurgical and general neuroscience journals are not immune to this problem. Academic institutions and ethics committees have a duty to raise awareness of this phenomenon and provide information and support to authors and the whole scientific community to avoid its propagation and potential control of biomedical publishing. Copyright © 2017 Sociedad Española de Neurocirugía. Publicado por Elsevier España, S.L.U. All rights reserved.

  14. Una Visita al Viejo San Juan (A Visit to Old San Juan).

    ERIC Educational Resources Information Center

    Cabello, Victor; And Others

    Written in Spanish, this black and white illustrated booklet provides a tour of Old San Juan, Puerto Rico's oldest and most historic city. Brief historical information is provided on the Perro de San Jeronimo, a statue of a barking dog found in front of the Castillo; Plaza de Colon, a small plaza dedicated to Christopher Columbus; the Catedral de…

  15. Una ricerca sul bilinguismo precoce italo-inglese (Research on Early Italian-English Bilingualism).

    ERIC Educational Resources Information Center

    Taeschner, Traute; And Others

    1978-01-01

    The purpose of this study was to attempt to verify the theory of Taeschner and Volterra (1976) that bilingual children pass through three distinct phases while becoming perfectly bilingual. The 12 subjects were English-Italian bilingual children between the ages of 1.6 and 4.6. (CFM)

  16. Diseno y desarrollo de una base de datos bibliograficos (Design and Development of a Bibliographic Database).

    ERIC Educational Resources Information Center

    Mattenella, L. E.; Velazco, J. W.

    1992-01-01

    This article briefly describes the development of bibliographic retrieval systems in the Instituto de Beneficio di Minerales (IN BE MI) in Salta, Argentina, using the Mini-micro CDS/ISIS software developed by Unesco. (LRW)

  17. Mediacion en educacion especial: Una guia para los padres (Special Education Mediation: A Guide for Parents).

    ERIC Educational Resources Information Center

    Consortium for Appropriate Dispute Resolution in Special Education (CADRE), Eugene, OR.

    Designed for Spanish-speaking parents of students with disabilities living in Oregon, this brochure describes the general mediation process that parents can use to resolve special education services disputes with schools. It begins by discussing what mediation is and the characteristics of a trained mediator. It addresses the requirement for…

  18. Chile: Una Vision Politica, Economica y Social (Chile: A Political, Economic, and Social View).

    ERIC Educational Resources Information Center

    Cortes-Hwang, Adriana

    1972-01-01

    This address seeks to explain in brief the historical background and political, economic, and social conditions leading to the democratic election of a Marxist president in Chile. A historical sketch of Chilean government from independence in 1810 is provided with a description of the situation just before Salvador Allende's election in 1969. Some…

  19. Historia de vidas de profesoras de ciencias: Hacia una ensenanza cientifica de calidad

    NASA Astrophysics Data System (ADS)

    Vega Osorio, Melba

    The purpose of this research was to capture the memories, practices, thoughts and philosophies of education that four experienced Science teachers have accumulated through the years. The life story qualitative research design was used in order to collect more meaningful information from the participants amenable to in depth analysis and interpretation. The life stories interviews were conducted using an interview protocol especially designed for the study. The interviews were recorded and transcribed. The questions that guided this research are: 1. What are the meanings that science teachers give to their educational practices? 2. How did the life experiences of the participants contribute to their success as science teachers? 3. How did the participants' educational practices change and evolve over time? 4. What does teaching science mean in the life of the participants? 5. Which reflections arise from the work of the participants that impact the teaching of science? 6. What are the participants' conceptions about teachers' professional development? 7. What are the participants' contributions to the field of scientific education? Wolcott's (1994) DAI analytical model was used for the analysis of the information and the narratives were written following the three dimensions of the model: description, analysis and interpretation. According to the life stories of the participants, being a teacher requires more than teaching the content. To be a successful and an exemplary science teacher, they have to live the teaching vocation, with dedication, passion, commitment and love for teaching, for students and science; teachers have to give their best for the students, even if it means making personal sacrifices; they should keep updated in knowledge (content) and in educational innovations (strategies); emphasizing both the theoretical and the practical aspects in the field of science, and being an inspirational guide for students.

  20. PREVENCIÓN DEL VIH/SIDA EN LOS CIRCUITOS DE LEVANTE HSH: UNA ASIGNATURA PENDIENTE.

    PubMed

    Barreda, Victoria; Carballo-Dieguez, Alex; Marone, Rubén; Balán, Iván; Pando, María Ángeles; Avila, María Mercedes

    2010-12-01

    A partir de un relevamiento de tipo etnográfico, se describen lugares de encuentro de HSH en la Ciudad de Buenos Aires y sus prácticas sexuales. El reconocimiento de tales espacios, así como las características que asumen en ellos los encuentros sexuales entre los HSH, plantean obstáculos específicos en la adopción de comportamientos preventivos y, asimismo, generan nuevos desafíos para las actividades de prevención. Se plantean las dificultades y debates conceptuales que la misma categoría presenta, y sus consecuencias en el abordaje preventivo y teórico-metodológico para las ciencias sociales. Además, se proponen nuevos interrogantes acerca de los alcances y las limitaciones del modelo preventivo del VIH/Sida para HSH.

  1. Una nina adoptada su conducta en el jardin de infantes (An Adopted Girl's Conduct in Preschool).

    ERIC Educational Resources Information Center

    Truscello de Mason, Marile

    1994-01-01

    Reports observations made by a preschool teacher in Argentina about a four-year-old adopted girl in her preschool. The teacher noticed problems between the girl and her adoptive mother, who tried to prevent the girl from remembering her past. The teacher particularly noticed changes in the girl's drawings. (AA)

  2. Una guia a los padres acerca del sistema educacional = A Parent's Guide to Education. Spanish Edition.

    ERIC Educational Resources Information Center

    Rowch, Nancy

    A guide for Spanish-speaking parents of elementary and secondary school students in Nebraska provides in Spanish, and then in English, information concerning education in the state. Topics covered include: state policy concerning enrolling children in school, medical requirements for enrollment and attendance, the school curriculum requirements…

  3. The complete chloroplast and mitochondrial genomes of the green macroalga Ulva sp. UNA00071828 (Ulvophyceae, Chlorophyta).

    PubMed

    Melton, James T; Leliaert, Frederik; Tronholm, Ana; Lopez-Bautista, Juan M

    2015-01-01

    Sequencing mitochondrial and chloroplast genomes has become an integral part in understanding the genomic machinery and the phylogenetic histories of green algae. Previously, only three chloroplast genomes (Oltmannsiellopsis viridis, Pseudendoclonium akinetum, and Bryopsis hypnoides) and two mitochondrial genomes (O. viridis and P. akinetum) from the class Ulvophyceae have been published. Here, we present the first chloroplast and mitochondrial genomes from the ecologically and economically important marine, green algal genus Ulva. The chloroplast genome of Ulva sp. was 99,983 bp in a circular-mapping molecule that lacked inverted repeats, and thus far, was the smallest ulvophycean plastid genome. This cpDNA was a highly compact, AT-rich genome that contained a total of 102 identified genes (71 protein-coding genes, 28 tRNA genes, and three ribosomal RNA genes). Additionally, five introns were annotated in four genes: atpA (1), petB (1), psbB (2), and rrl (1). The circular-mapping mitochondrial genome of Ulva sp. was 73,493 bp and follows the expanded pattern also seen in other ulvophyceans and trebouxiophyceans. The Ulva sp. mtDNA contained 29 protein-coding genes, 25 tRNA genes, and two rRNA genes for a total of 56 identifiable genes. Ten introns were annotated in this mtDNA: cox1 (4), atp1 (1), nad3 (1), nad5 (1), and rrs (3). Double-cut-and-join (DCJ) values showed that organellar genomes across Chlorophyta are highly rearranged, in contrast to the highly conserved organellar genomes of the red algae (Rhodophyta). A phylogenomic investigation of 51 plastid protein-coding genes showed that Ulvophyceae is not monophyletic, and also placed Oltmannsiellopsis (Oltmannsiellopsidales) and Tetraselmis (Chlorodendrophyceae) closely to Ulva (Ulvales) and Pseudendoclonium (Ulothrichales).

  4. Una Metodologia de Analisis de la Interaccion Alumno-Orgendaor en la Investigacion Sobre Informatica Educativa.

    ERIC Educational Resources Information Center

    Estepa, A.; And Others

    1992-01-01

    The recording of the interaction between pupil and computer is one of the data sources frequently used in research on the use of computers in teaching. Describes the analysis methodology of these recordings to determine the use of computers in statistics and its adaptation to other research work on the use of computers in education. (Author/MDH)

  5. Borders and Identity: A Resource Guide for Teachers = Identidad y Fronteras: Una Guia para Maestros.

    ERIC Educational Resources Information Center

    Belauus, Betty; Botein, Emily; Cadaval, Olivia

    The materials in this resource guide include a four-part video, a poster-size cultural map with additional exercises, and the five sections of this guide. The unit, presented in English and Spanish, intends to introduce students to the peoples and cultures of the U.S.-Mexico border, to explore the concept of borders in their own communities, to…

  6. Hacia una vision total del hablante espanol (Toward a Total View of the Spanish Speaker).

    ERIC Educational Resources Information Center

    Poyatos, Fernando

    To understand the Spanish speaker one must be aware of the many facets of Hispanic culture and the various means of communicating that language and that culture. The two main forms of communication, linguistics and paralinguistics, convey the speaker's behavior and identify him as a member of the Hispanic culture. Linguistic patterns in Spanish…

  7. Estrellas Wolf-Rayet y el medio interestelar: huellas de una fuerte interacción

    NASA Astrophysics Data System (ADS)

    Cichowolski, S.; Arnal, E. M.

    Se presentan resultados observacionales de un estudio de la distribución de hidrógeno neutro en los alrededores de estrellas Wolf-Rayet (WR) galácticas. Los datos de la línea de 21 cm provienen de observaciones de resolución angular intermedia (9') tomadas con el radiotelescopio de Effelsberg. La muestra está compuesta por cuatro WR de la serie del nitrógeno (WN): WR130, WR131, WR155, WR156 y tres WR de la serie del carbono (WC): WR154, WR117 y WR126. Este análisis ha permitido detectar cavidades y envolturas de HI en expansión presumiblemente vinculadas a dichas estrellas.

  8. "Una Nacion Acorralada": Southern Peruvian Quechua Language Planning and Politics in Historical Perspective.

    ERIC Educational Resources Information Center

    Mannheim, Bruce

    1984-01-01

    Outlines history of Spanish colonial policies toward Southern Peruvian Quechua and points out those issues under debate concerning the indigenous languages. The central issue of the "Andean language debate" continues to be whether or not the Quechua have a right to exist as a separate community. (SL)

  9. Una Metodologia de Analisis de la Interaccion Alumno-Orgendaor en la Investigacion Sobre Informatica Educativa.

    ERIC Educational Resources Information Center

    Estepa, A.; And Others

    1992-01-01

    The recording of the interaction between pupil and computer is one of the data sources frequently used in research on the use of computers in teaching. Describes the analysis methodology of these recordings to determine the use of computers in statistics and its adaptation to other research work on the use of computers in education. (Author/MDH)

  10. Una Red de Expertos en Salud Ambiental de Niños (2015)

    EPA Pesticide Factsheets

    Unidades Pediátricas de Especialidad en Salud Ambiental (PEHSU) tiene expertos en pediatria, alergias e inmunologia, desarrollo neural, toxicologia, y otras, ya que existen varios factores que afectan la salud de los ninos.

  11. Perspectiva sobre una Personalidad Senera: Carmen Fischer Ramirez (Perspective on a Singular Personality: Carmen Fischer Ramirez).

    ERIC Educational Resources Information Center

    Quezeda, Dina Alarcon

    1992-01-01

    Traces the career of Carmen Fischer Ramirez, focusing on her work in improving early childhood education in Chile. Reviews her university career, work with the World Organization for Early Childhood Education, and major publications. (AC)

  12. Tengo una Bomba: The Paralinguistic and Linguistic Conventions of the Oral Practice Chismeando.

    ERIC Educational Resources Information Center

    Hall, Joan Kelly

    1993-01-01

    This article offers a linguistic and paralinguistic explication of the oral practice of chismeando (gossiping) as engaged in by a group of women from the Dominican Republic. A culture-specific study of the structuring resources by which the participants construct, maintain, and/or modify their in-group identities in everyday oral practice is…

  13. Confieso que Divulgo. Reflexiones y Experiencias de una Astrofísica

    NASA Astrophysics Data System (ADS)

    Rodríguez Hidalgo, I.

    Este artículo presenta algunas reflexiones en torno a la popularización de la Ciencia, desarrolladas a lo largo de mi trayectoria profesional, un camino inacabado desde la intuición al oficio. Tras revisar las señas de identidad de la divulgación científica, se exponen ideas, experiencias y recursos, cribados por la práctica y su posterior análisis crítico. Se destacan las actividades relacionadas con la Astronomía, que se cuentan entre las más espectaculares y gratificantes. Confessions of a popularizer: This paper presents some author's thoughts about scientific outreach, developed along her professional path, an unfinished way from intuition to trade. First, identity signs of outreach are revised; then, ideas, experiences and resources, sifted by practice and further critical analysis, are reviewed. Activities related to Astronomy, being one of the most spectacular and rewarding, are remarked 1

  14. Una Visita al Viejo San Juan (A Visit to Old San Juan).

    ERIC Educational Resources Information Center

    Cabello, Victor; And Others

    Written in Spanish, this black and white illustrated booklet provides a tour of Old San Juan, Puerto Rico's oldest and most historic city. Brief historical information is provided on the Perro de San Jeronimo, a statue of a barking dog found in front of the Castillo; Plaza de Colon, a small plaza dedicated to Christopher Columbus; the Catedral de…

  15. Una guia para los padres a la educacion preescolar (A Parent's Guide to Preschool).

    ERIC Educational Resources Information Center

    Dodge, Diane Trister; Phinney, Joanna

    This booklet, in Spanish- and Japanese-language versions, offers parents guidance on how to partner with teachers to help their children acquire the skills, attitudes, and habits to do well in school and throughout life. The booklet begins with a description of how preschool children learn, and continues with a discussion of the goals of the…

  16. Una Experiencia Pedagogica en el Jardin Infantil "La Cabana" (A Teaching Experience in "La Cabana" Kindergarten).

    ERIC Educational Resources Information Center

    de la Vega, B.

    1992-01-01

    Reviews the history of La Cabana kindergarten, which provides preschool education and meals for 100 children and sewing classes for mothers in a working class neighborhood in Bogota, Colombia. Describes the implementation of a new curriculum which develops child creativity through free choice of activities around a common project. (AC)

  17. Una nina adoptada su conducta en el jardin de infantes (An Adopted Girl's Conduct in Preschool).

    ERIC Educational Resources Information Center

    Truscello de Mason, Marile

    1994-01-01

    Reports observations made by a preschool teacher in Argentina about a four-year-old adopted girl in her preschool. The teacher noticed problems between the girl and her adoptive mother, who tried to prevent the girl from remembering her past. The teacher particularly noticed changes in the girl's drawings. (AA)

  18. Areas Nacionales de Estudio Ambiental: Una Guia. (National Environmental Study Area: A Guide).

    ERIC Educational Resources Information Center

    National Park Service (Dept. of Interior), Washington, DC.

    This booklet, the Spanish version of SE 014 817, is a guide for teachers and resource managers who are interested in establishing National Environmental Study Areas (NESA) or interested in receiving NESA recognition for their on-going environmental study area programs. It outlines the characteristics and procedures of the program; the nature,…

  19. Modelo empirico integral de una plantacion de Eucalyptus grandis en Concordia, Entre Rios

    Treesearch

    Jorge Frangi; Carolina Perez; Juan Goya; Natalia Teson; Marcelo Barrera; Marcelo Arturi

    2016-01-01

    The Argentinian Mesopotamia is the core of fast-growing tree species plantations of the country. Eucalyptus grandis plantations constitute 90 % of the forested area with Eucalyptus spp. in NE Entre Rios. Based on previous studies on structural and functional features, a comprehensive model is here proposed on emergence of new properties linked to matter and ecosystem...

  20. Habitos Alimentarios e Higiene Dental en una Poblacion Preescolar de Madrid.

    ERIC Educational Resources Information Center

    Lafarga, R. Tarazona; And Others

    1991-01-01

    Nutriment habits and oral hygiene in a preschool population in Madrid were studied by stratification in public or private schools. Significant differences were found only with regard to consumption of fish. Vegetable and fruit consumption was low in both groups, but not statistically significant. (SH)

  1. Per una pedagogia della comprensione interculturale (A Method for Teaching Intercultural Understanding).

    ERIC Educational Resources Information Center

    Titone, Renzo

    1986-01-01

    Defines true bilingualism as biculturalism, explains what "understanding" another culture means, and describes how to evaluate the effectiveness of teaching methods for students from different cultures. Ideally, individuals learning a second language will acquire a "metacultural" consciousness that permits them to be comfortable in any cultural…

  2. The Puerto Ricans--Two Communities, One Culture. (Los Puertorriquenos--Dos Comunidades, Una Cultura.)

    ERIC Educational Resources Information Center

    Vivo, Paquita

    1980-01-01

    Puerto Rican roots stem from the ethnic mixture of Indians, Europeans, and Africans. This article describes the advent of each of the groups on the island, the historical and cultural impact each made, and the retention of heritage among Puerto Rican migrants to the U.S. (DS)

  3. Una guia a los padres acerca del sistema educacional = A Parent's Guide to Education. Spanish Edition.

    ERIC Educational Resources Information Center

    Rowch, Nancy

    A guide for Spanish-speaking parents of elementary and secondary school students in Nebraska provides in Spanish, and then in English, information concerning education in the state. Topics covered include: state policy concerning enrolling children in school, medical requirements for enrollment and attendance, the school curriculum requirements…

  4. "Necesita una vacuna": what Spanish-speakers want in text-message immunization reminders.

    PubMed

    Ahlers-Schmidt, Carolyn R; Chesser, Amy; Brannon, Jennifer; Lopez, Venessa; Shah-Haque, Sapna; Williams, Katherine; Hart, Traci

    2013-08-01

    Appointment reminders help parents deal with complex immunization schedules. Preferred content of text-message reminders has been identified for English-speakers. Spanish-speaking parents of children under three years old were recruited to develop Spanish text-message immunization reminders. Structured interviews included questions about demographic characteristics, use of technology, and willingness to receive text reminders. Each participant was assigned to one user-centered design (UCD) test: card sort, needs analysis or comprehension testing. Respondents (N=54) were female (70%) and averaged 27 years of age (SD=7). A card sort of 20 immunization-related statements resulted in identification of seven pieces of critical information, which were compiled into eight example texts. These texts were ranked in the needs assessment and the top two were assessed for comprehension. All participants were able to understand the content and describe intention to act. Utilizing UCD testing, Spanish-speakers identified short, specific text content that differed from preferred content of English-speaking parents.

  5. "Una etapa siempre dificil": Concepts of Adolescence and Secondary Education in Mexico.

    ERIC Educational Resources Information Center

    Levinson, Bradley A.

    1999-01-01

    Draws on ethnographic observations, historical sources, and official documents to examine the historical and contemporary connections among the Mexican "secundaria" (junior high school), the broader ideological and political-economic context of Mexican educational development, and concepts of adolescence in both expert discourse and…

  6. Per una pedagogia della comprensione interculturale (A Method for Teaching Intercultural Understanding).

    ERIC Educational Resources Information Center

    Titone, Renzo

    1986-01-01

    Defines true bilingualism as biculturalism, explains what "understanding" another culture means, and describes how to evaluate the effectiveness of teaching methods for students from different cultures. Ideally, individuals learning a second language will acquire a "metacultural" consciousness that permits them to be comfortable in any cultural…

  7. Luchando por una educacion: A Qualitative Understanding of Undocumented Latina/o College Student Motivation

    ERIC Educational Resources Information Center

    Navarro, Elvia Lorena

    2013-01-01

    The current qualitative study explored the factors and resources that motivate undocumented Latino/a college students to persist in higher education. Through the data obtained from the four qualitative open-ended survey questions, a content analysis revealed specific codes, themes, and subthemes addressing the factors and resources that motivate…

  8. Borders and Identity: A Resource Guide for Teachers = Identidad y Fronteras: Una Guia para Maestros.

    ERIC Educational Resources Information Center

    Belauus, Betty; Botein, Emily; Cadaval, Olivia

    The materials in this resource guide include a four-part video, a poster-size cultural map with additional exercises, and the five sections of this guide. The unit, presented in English and Spanish, intends to introduce students to the peoples and cultures of the U.S.-Mexico border, to explore the concept of borders in their own communities, to…

  9. Diseno y desarrollo de una base de datos bibliograficos (Design and Development of a Bibliographic Database).

    ERIC Educational Resources Information Center

    Mattenella, L. E.; Velazco, J. W.

    1992-01-01

    This article briefly describes the development of bibliographic retrieval systems in the Instituto de Beneficio di Minerales (IN BE MI) in Salta, Argentina, using the Mini-micro CDS/ISIS software developed by Unesco. (LRW)

  10. I Didn't Say a Word/No Dije una Palabra.

    ERIC Educational Resources Information Center

    Bielawski, Joseph G.; Pickens, Marjorie

    This bilingual English/Spanish book of captioned photographs and its related teaching manual were created as a joyful experience in nonverbal communication for children and adults. It is intended to sharpen awareness of nonverbal messages expressed by children in their everyday environment. To help develop self-understanding and to encourage oral…

  11. The Struggle for Mexico's First Gay-Straight Alliance: Como una Novela Real

    ERIC Educational Resources Information Center

    Macgillivray, Ian K.

    2006-01-01

    In 2004, a group of high school students at a private American school in Mexico City started the first gay-straight alliance in Mexico. A small group of conservative parents and a Mormon principal organized in opposition. This paper details the students' struggle to keep their club and offers lessons learned about student activism, school change,…

  12. Community Resources Guide for Central Florida = Una Guia de Recursos en la Comunidad de Florida Central.

    ERIC Educational Resources Information Center

    Medina, Linda, Comp.

    Designed to orient Hispanic refugees to the services that are available in Central Florida, this bilingual guide consists of a section of general information on living and working in the United States and a section devoted to various public and private agencies. Provided first are addresses and phone numbers of various government agencies:…

  13. Perspectiva sobre una Personalidad Senera: Carmen Fischer Ramirez (Perspective on a Singular Personality: Carmen Fischer Ramirez).

    ERIC Educational Resources Information Center

    Quezeda, Dina Alarcon

    1992-01-01

    Traces the career of Carmen Fischer Ramirez, focusing on her work in improving early childhood education in Chile. Reviews her university career, work with the World Organization for Early Childhood Education, and major publications. (AC)

  14. The Puerto Ricans--Two Communities, One Culture. (Los Puertorriquenos--Dos Comunidades, Una Cultura.)

    ERIC Educational Resources Information Center

    Vivo, Paquita

    1980-01-01

    Puerto Rican roots stem from the ethnic mixture of Indians, Europeans, and Africans. This article describes the advent of each of the groups on the island, the historical and cultural impact each made, and the retention of heritage among Puerto Rican migrants to the U.S. (DS)

  15. I Didn't Say a Word/No Dije una Palabra.

    ERIC Educational Resources Information Center

    Bielawski, Joseph G.; Pickens, Marjorie

    This bilingual English/Spanish book of captioned photographs and its related teaching manual were created as a joyful experience in nonverbal communication for children and adults. It is intended to sharpen awareness of nonverbal messages expressed by children in their everyday environment. To help develop self-understanding and to encourage oral…

  16. Historia Verdadera de Una Gota de Miel. (The True Story of a Drop of Honey).

    ERIC Educational Resources Information Center

    Galarza, Ernesto

    Part of the series "Coleccion Mini-Libros" (Mini-Book Collection), the booklet is a factual account of the life of a bee. Designed to provide a tool for education of the Spanish-speaking child, as well as to stimulate an interest in Spanish among the youth of our country, the publication is a compilation of photographs with a description of bees…

  17. Una Experiencia Pedagogica en el Jardin Infantil "La Cabana" (A Teaching Experience in "La Cabana" Kindergarten).

    ERIC Educational Resources Information Center

    de la Vega, B.

    1992-01-01

    Reviews the history of La Cabana kindergarten, which provides preschool education and meals for 100 children and sewing classes for mothers in a working class neighborhood in Bogota, Colombia. Describes the implementation of a new curriculum which develops child creativity through free choice of activities around a common project. (AC)

  18. Validacion de Una Version Preliminar del Child Abuse Potential Inventory para su Uso en Argentina.

    ERIC Educational Resources Information Center

    Bringiotti, Maria Ines; Barbich, Alejandra; De Paul, Joaquin

    1998-01-01

    The validity of the Child Abuse Potential (CAP) Inventory was tested with a sample of 40 child physical abusers and 40 nonabusers in Argentina. More than 97% of subjects were correctly classified as abusing or nonabusing individuals. The article is in Spanish. (CR)

  19. Una ricerca sul bilinguismo precoce italo-inglese (Research on Early Italian-English Bilingualism).

    ERIC Educational Resources Information Center

    Taeschner, Traute; And Others

    1978-01-01

    The purpose of this study was to attempt to verify the theory of Taeschner and Volterra (1976) that bilingual children pass through three distinct phases while becoming perfectly bilingual. The 12 subjects were English-Italian bilingual children between the ages of 1.6 and 4.6. (CFM)

  20. Una guia para los padres a la educacion preescolar (A Parent's Guide to Preschool).

    ERIC Educational Resources Information Center

    Dodge, Diane Trister; Phinney, Joanna

    This booklet, in Spanish- and Japanese-language versions, offers parents guidance on how to partner with teachers to help their children acquire the skills, attitudes, and habits to do well in school and throughout life. The booklet begins with a description of how preschool children learn, and continues with a discussion of the goals of the…

  1. Mi Vecina es una Mujer Colpeada (My Neighbor Is a Battered Woman).

    ERIC Educational Resources Information Center

    Howard, Melissa

    This book, the Spanish version of "My Neighbor is a Battered Woman," is intended as a general introduction to the problems of battered women. The format for part 1 consists of the presentation of facts about wife beating, i.e., who are victims, characteristics of batterers, the environment in which family violence exists, and services…

  2. "Una etapa siempre dificil": Concepts of Adolescence and Secondary Education in Mexico.

    ERIC Educational Resources Information Center

    Levinson, Bradley A.

    1999-01-01

    Draws on ethnographic observations, historical sources, and official documents to examine the historical and contemporary connections among the Mexican "secundaria" (junior high school), the broader ideological and political-economic context of Mexican educational development, and concepts of adolescence in both expert discourse and…

  3. "...Una Etapa Siempre Dificil": Concepts of Adolescence and Programs of Secondary Education in Mexico.

    ERIC Educational Resources Information Center

    Levinson, Bradley A.

    An American visiting a Mexican secundaria (equivalent to the U.S. junior high school) noted the strong presence of discourses on "adolescence." This prompted an ideological and historical review of the secundaria since its development in the postrevolutionary ethos of the 1920s-30s. Inspired by a U.S. model of adolescent education in the…

  4. Una experiencia europea de innovacion pedagogica basada en la escritura de un ibro.

    ERIC Educational Resources Information Center

    Montane, Mireia; Roc, Merce

    2002-01-01

    Describes a European project based on writing a book from an educational perspective. Participants included 18 schools from 13 countries. The study originated in a Spanish Comenius 3.1 project, which determined that university teams would visit "book writing" schools, supporting teachers and analyzing and publishing their experiences.…

  5. The Complete Chloroplast and Mitochondrial Genomes of the Green Macroalga Ulva sp. UNA00071828 (Ulvophyceae, Chlorophyta)

    PubMed Central

    Melton, James T.; Leliaert, Frederik; Tronholm, Ana; Lopez-Bautista, Juan M.

    2015-01-01

    Sequencing mitochondrial and chloroplast genomes has become an integral part in understanding the genomic machinery and the phylogenetic histories of green algae. Previously, only three chloroplast genomes (Oltmannsiellopsis viridis, Pseudendoclonium akinetum, and Bryopsis hypnoides) and two mitochondrial genomes (O. viridis and P. akinetum) from the class Ulvophyceae have been published. Here, we present the first chloroplast and mitochondrial genomes from the ecologically and economically important marine, green algal genus Ulva. The chloroplast genome of Ulva sp. was 99,983 bp in a circular-mapping molecule that lacked inverted repeats, and thus far, was the smallest ulvophycean plastid genome. This cpDNA was a highly compact, AT-rich genome that contained a total of 102 identified genes (71 protein-coding genes, 28 tRNA genes, and three ribosomal RNA genes). Additionally, five introns were annotated in four genes: atpA (1), petB (1), psbB (2), and rrl (1). The circular-mapping mitochondrial genome of Ulva sp. was 73,493 bp and follows the expanded pattern also seen in other ulvophyceans and trebouxiophyceans. The Ulva sp. mtDNA contained 29 protein-coding genes, 25 tRNA genes, and two rRNA genes for a total of 56 identifiable genes. Ten introns were annotated in this mtDNA: cox1 (4), atp1 (1), nad3 (1), nad5 (1), and rrs (3). Double-cut-and-join (DCJ) values showed that organellar genomes across Chlorophyta are highly rearranged, in contrast to the highly conserved organellar genomes of the red algae (Rhodophyta). A phylogenomic investigation of 51 plastid protein-coding genes showed that Ulvophyceae is not monophyletic, and also placed Oltmannsiellopsis (Oltmannsiellopsidales) and Tetraselmis (Chlorodendrophyceae) closely to Ulva (Ulvales) and Pseudendoclonium (Ulothrichales). PMID:25849557

  6. GERBERTVS una nuova rivista per l'astronomia e la scienza nell'alto medioevo

    NASA Astrophysics Data System (ADS)

    Sigismondi, C.

    GERBERTVS appears as an international e-journal on medieval science, namely astronomy. It has been created to gather all the studia promoted on Gerbert of Aurillac, the most prominent figure of the tenth century: astronomer, organ builder and music theoretician, mathematician, philosopher, and finally pope with the name of Silvester II (999-1003). Here is presented the first volume (2010) published in the institutional web site www.icra.it/gerbertus with the ISSN 2038-355X.

  7. Cuentos Faciles. Habia una vez.... (Simple Stories. There was a Time....) (Presenting Simple Stories in Spanish.)

    ERIC Educational Resources Information Center

    Arroyo, Nancy; And Others

    For Spanish-speaking children, simple stories in Spanish, told in a natural language suitable for their age, are not only entertaining, but a means of developing vocabulary and concepts. Non-Spanish-speaking children, too, need exposure to more language than they can understand word for word. However, the simple stories for the Spanish speaker…

  8. [Clip Sheets from BOCES. Opportunities. Health. Careers. = Oportunidades. Salud. Una Camera En...

    ERIC Educational Resources Information Center

    State Univ. of New York, Geneseo. Coll. at Geneseo. Migrant Center.

    This collection of 83 clip sheets, or classroom handouts, was created to help U.S. migrants learn more about health, careers, and general "opportunities" including education programs. They are written in both English and Spanish and are presented in an easily understandable format. Health clip-sheet topics include the following: Abuse; AIDS;…

  9. Renovando la Esperanza por una Educacion sin Exclusiones (Rekindling the Hope for an Education without Exclusion).

    ERIC Educational Resources Information Center

    Revista Interamericana de Educacion de Adultos, 2001

    2001-01-01

    Articles in this issue, written in Spanish, focus on the following: current status and outlook of youth and adult education; opening statement of the 50th anniversary commemoration; regional framework for the education of youth and adults in Latin America and the Caribbean; interculturalism and the education of youth and adults; participation of…

  10. The Struggle for Mexico's First Gay-Straight Alliance: Como una Novela Real

    ERIC Educational Resources Information Center

    Macgillivray, Ian K.

    2006-01-01

    In 2004, a group of high school students at a private American school in Mexico City started the first gay-straight alliance in Mexico. A small group of conservative parents and a Mormon principal organized in opposition. This paper details the students' struggle to keep their club and offers lessons learned about student activism, school change,…

  11. Guia Practica para una Evaluacion Alternativa (Practical Guide to Alternative Assessment).

    ERIC Educational Resources Information Center

    Herman, Joan L.; Aschbacher, Pamela R.; Winters, Lynn

    Guidance is offered in Spanish on the creation and use of alternative assessment, and a process model is presented that links assessment with curriculum and instruction, based on contemporary theories of learning and cognition. The introductory chapter provides background on the purposes of assessment and the need for new alternatives, with an…

  12. Historia Verdadera de Una Gota de Miel. (The True Story of a Drop of Honey).

    ERIC Educational Resources Information Center

    Galarza, Ernesto

    Part of the series "Coleccion Mini-Libros" (Mini-Book Collection), the booklet is a factual account of the life of a bee. Designed to provide a tool for education of the Spanish-speaking child, as well as to stimulate an interest in Spanish among the youth of our country, the publication is a compilation of photographs with a description of bees…

  13. Sistemas Eolicos Pequenos para Generacion de Electricidad: Una guia para consumidores en Nuevo Mexico

    SciTech Connect

    Not Available

    2007-09-01

    This Spanish version of the popular Small Wind Electric Systems: A New Mexico Consumer's Guide provides consumers with information to help them determine whether a small wind electric system can provide all or a portion of the energy they need for their home or business based on their wind resource, energy needs, and economics. Topics include how to make a home more energy efficient, how to choose the correct turbine size, the parts of a wind electric system, how to determine whether enough wind resource exists, how to choose the best site for a turbine, how to connect a system to the utility grid, and whether it's possible to become independent of the utility grid using wind energy. In addition, the cover of the guide contains a list of contacts for more information.

  14. Sistemas Eolicos Pequenos para Generacion de Electricidad; Una guia para consumidores en los EE.UU.

    SciTech Connect

    Not Available

    2007-09-01

    This Spanish version of the popular Small Wind Electric Systems: A U.S. Consumer's Guide provides consumers with information to help them determine whether a small wind electric system can provide all or a portion of the energy they need for their home or business based on their wind resource, energy needs, and economics. Topics include how to make a home more energy efficient, how to choose the correct turbine size, the parts of a wind electric system, how to determine whether enough wind resource exists, how to choose the best site for a turbine, how to connect a system to the utility grid, and whether it's possible to become independent of the utility grid using wind energy. In addition, the cover of the guide contains a list of contacts for more information.

  15. Tengo una Bomba: The Paralinguistic and Linguistic Conventions of the Oral Practice Chismeando.

    ERIC Educational Resources Information Center

    Hall, Joan Kelly

    1993-01-01

    This article offers a linguistic and paralinguistic explication of the oral practice of chismeando (gossiping) as engaged in by a group of women from the Dominican Republic. A culture-specific study of the structuring resources by which the participants construct, maintain, and/or modify their in-group identities in everyday oral practice is…

  16. Exploración del Sistema Solar -- Una mirada hacia el futuro

    NASA Image and Video Library

    ¿Piensas que ya sabemos todo acerca de nuestro sistema solar? La realidad es que apenas hemos comenzado con lo que hay para conocer. Únete a la NASA, en el envío de misiones a los confines del sist...

  17. Protegiendo a nuestros ninos: una guia de accion (Safeguarding Our Children: An Action Guide).

    ERIC Educational Resources Information Center

    American Institutes for Research, Washington, DC. Center for Effective Collaboration and Practice.

    Although most schools are safe, they all can be safer. Improving school safety requires the strategic investment of time and dollars--scarce resources for which there are competing demands. Fortunately, schools that strategically coordinate schoolwide efforts are more likely to improve academic performance as well as reduce behavior problems. This…

  18. Establishing the Empirical Relationship Between Non-Science Majoring Undergraduate Learners' Spatial Thinking Skills and Their Conceptual Astronomy Knowledge. (Spanish Title: Estableciendo Una Relación Empírica Entre el Razonamiento Espacial de los Estudiantes de Graduación de Carreras no Científicas y su Conocimento Conceptual de la Astronomía.) Estabelecendo Uma Relação Empírica Entre o RacioCínio Espacial dos Estudantes de Graduação EM Carreiras Não Científicas e Seu Conhecimento Conceitual da Astronomia

    NASA Astrophysics Data System (ADS)

    Heyer, Inge; Slater, Stephanie J.; Slater, Timothy F.

    2013-12-01

    The astronomy education community has tacitly assumed that learning astronomy is a conceptual domain resting upon spatial thinking skills. As a first step to formally identify an empirical relationship, undergraduate students in a non-major introductory astronomy survey class at a mediumsized, Ph.D. granting, mid-western US university were given pre- and post-astronomy conceptual diagnostics and spatial reasoning diagnostics, Instruments used were the "Test Of Astronomy Standards" and "What Do You Know?" Using only fully matched data for analysis, our sample consisted of 86 undergraduate non-science majors. Students' normalized gains for astronomy surveys were low at .26 and .13 respectively. Students' spatial thinking was measured using an instrument designed specifically for this study. Correlations between the astronomy instruments' pre- to post-course gain scores and the spatial assessment instrument show moderate to strong relationships suggesting the relationship between spatial reasoning and astronomy ability can explain about 25% of the variation in student achievement. La comunidad de educación en astronomía ha supuesto de forma tácita que el aprendizaje de la astronomía consiste en un dominio conceptual fundamentado en el razonamiento espacial. Como un primer paso para identificar formalmente una relación empírica entre estas dos cosas, utilizamos como muestra los estudantes de graduación de carreras no científicas de un curso experimental en una universidad norteamericana del medioeste de porte mediano con programa de Doctorado em curso, en el cual estos estudiantes se sometieron a un diagnóstico de razonamiento espacial y conceptos astronómicos antes e después del mismo. Las herramientas utilizadas fueron el Test Of Astronomy Standards (TOAST) y el cuestionario What do you know? Utilizando solo los datos completamente consistentes para este análisis, nuestra muestra consistió en 86 estudantes de graduación. Las mejoras, depués de

  19. Three-port colectomy: reduced port laparoscopy for general surgeons. A single center experience.

    PubMed

    Cocorullo, Gianfranco; Tutino, Roberta; Falco, Nicolò; Salamone, Giuseppe; Gulotta, Gaspare

    Le resezioni coliche laparoscopiche sia per patologie benigne che maligne sono state investigate da importanti RCT che ne hanno dimostrato la sovrapponibilità alla tecnica open convenzionale. La laparoscopia con un numero ridotto di trocar ha da quel momento trovato ampio sviluppo nell’ottica di massimizzare i benefici della mini-invasività. Proponiamo un’analisi dei nostri risultati nell’utilizzo della tecnica three-port nella emicolectomia sinistra attraverso un confronto con la classica resezione laparoscopica con quattro/ cinque accessi. Come è noto i laparoceli si sviluppano maggiormente su incisioni mediane mentre non vi è differenza tra lo sviluppo di questi dopo tecnica open o laparoscopica. Nell’ottica della chirurgia a numero ridotto di accessi, la tecnica single-port sembra dare vantaggi di minor traumatismo ma ciò a costo di aumentate difficoltà di esecuzione, aumento dei tempi operatori e dell’utilizzo di strumenti per lo più dedicati, con incisioni ombelicali che possono superare i 5 cm. Le resezioni coliche three port consentono di ridurre il numero di accessi e dunque delle complicanze a questi correlate con l’utilizzo di strumentazione standard e la possibilità di esecuzione su larga scala da parte di ogni chirurgo. L’analisi che abbiamo eseguito ha dimostrato nella nostra serie una riduzione dei tempi operatori nella tecnica three port e ciò può essere dovuto all’inserimento dei trocar addizionali ed al loro controllo ma soprattutto alla possibilità/ necessità del chirurgo esperto di essere meno influenzato da fattori quali una equipe non dedicata. Non sono stati evidenziati vantaggi nella riduzione della degenza operatoria. Il tasso di conversione è stato maggiore nella tecnica a ridotto numero di accessi, questo è possibile sia un bias legato alle conversioni precoci prima del posizionamento di restanti trocar in casi particolarmente complessi. In conclusione, la tecnica three port appare comparabile alla

  20. Male courtship behavior in Ceratitis Capitata (Diptera: Tephritidae) that have received Aromatherapy with ginger root oil

    SciTech Connect

    Briceno, D.; Eberhard, W.; Shelly, T.

    2007-03-15

    criados en masa fueron apareados con hembras criadas en masa; sin embargo, cuando ellos fueron apareados con hembras naturales, resultaron unas pequenas diferencias. Los estudios previos indicaron que la eficacia de la feromona atrayente de machos de larga distancia no esta afectada por la aromaterapia, pero estos estudios no consideran las feromonas sueltas en un rango corto durante el cortejo, cuando el analisis de comportamiento sugiere que puede ser diferente. Nosotros proponemos la explicacion siguiente para los efectos diferentes de la aromaterapia con las diferentes hembras. La seleccion de machos bajo condiciones de cria en masa puede haber alterado las feromonas de rango corto de manera que puede ser remediada por la aromaterapia; y solamente las hembras naturales responden por que tambien ha cambiado la respuesta de las hembras criadas en masa a la feromona. Nosotros indicamos observaciones que pueden probar estas ideas. (author)

  1. An approach to complicated diverticular disease. A retrospective study in an Acute Care Surgery service recently established.

    PubMed

    Occhionorelli, Savino; Zese, Monica; Tartarini, Daniela; Lacavalla, Domenica; Maccatrozzo, Stefano; Groppo, Giacomo; Sibilla, Maria Grazia; Stano, Rocco; Cappellari, Lorenzo; Vasquez, Giorgio

    2016-01-01

    anastomosi sta diventando una valida alternativa, specie in pazienti selezionati. Per quanto concerne il lavaggio peritoneale laparoscopico, i Trials sono ancora in corso ed i risultati preliminari attualmente contrastanti. Conclusioni: A nostro giudizio la resezione e consensuale anastomosi è il trattamento d’elezione in pazienti selezionati e con ASA score bassi, mentre riserviamo l’intervento secondo Hartmann per i casi associati a maggiori fattori di rischio, anche se il problema del successivo reintervento per ricanalizzazione e chiusura di colostomia rimane dibattuto. Per quanto concerne il lavagio peritoneale laparoscopico, attendiamo i risultati dei Trials clinici ma al momento non ci sembra una procedura applicabile su larga scala.

  2. ASSESSMENT OF THE FOOD PATTERNS OF IMMIGRANT ECUADORIAN POPULATION IN SOUTHERN SPAIN BASED ON A 24-H FOOD RECALL SURVEY.

    PubMed

    Neira-Mosquera, Juan Alejandro; Sanchez-Llaguno, Sungey; Pérez-Rodríguez, Fernando; Moreno-Rojas, Rafael

    2015-08-01

    Introducción: ecuador es un país con limitada información nutricional con la excepción de algunos estudios de carácter general realizados por FAO (Food Agriculture Organization). Objetivos: realizar una evaluación nutricional de la dieta de la población inmigrante ecuatoriana en el sur de España para determinar diferencias en los patrones alimentarios y posibles deficiencias nutricionales. Métodos: la evaluación nutricional se basa en un estudio de recordatorio de alimentos de 24 horas llevado acabo sobre la población ecuatoriana residente en Sevilla y Córdoba (España) en combinación con la aplicación de bases de datos nacionales e internacionales de composición de alimentos. Se estimaron los niveles de ingesta de nutrientes y el cumplimiento de las ingestas dietéticas de referencia (IDR) que se analizaron estadísticamente para los factores, genero, edad, profesión y ciudad. Resultados: según las IDR utilizadas, la distribución de macronutrientes y los niveles de ingesta de nutrientes fueron, en la mayoría de los casos, adecuadas. De manera destacada, se constató que los hábitos alimentarios ecuatorianos permanecieron en la población inmigrante, con el arroz como fuente principal de energía. Los niveles de ingesta fueron significativamente diferentes para diferentes nutrientes dependiendo del grupo de edad, sexo, lugar de residencia y ocupación profesional. Comparando estos datos con un estudio previo en Ecuador reveló que la población inmigrante en España presenta un mejor estado nutricional, si bien en ambas poblaciones se detectaron deficiencias en fibra, vitamina E, I y Se. En cuanto a estas deficiencias, los resultados no pueden considerarse concluyentes debido a limitaciones propias de las bases de datos (por ej. Se) y a la carencia de estudios adecuados que permitan una evaluación más precisa (por ej. estudios de larga duración para vitamina E). Conclusiones: estos resultados evidencian que la población inmigrante

  3. When Did the Swahili Become Maritime?

    PubMed Central

    Fleisher, Jeffrey; Lane, Paul; LaViolette, Adria; Horton, Mark; Pollard, Edward; Quintana Morales, Eréndira; Vernet, Thomas; Christie, Annalisa; Wynne-Jones, Stephanie

    2015-01-01

    esta sociedad costera entre el primer y segundo milenio. Éstas son la variabilidad y discontinuidad en la localización y permanencia de los asentamientos; evidencia de una conexión mayor con el mar a través de la tecnología de pesca y navegación; y desarrollos arquitectónicos especializados que incluyen instalaciones portuarias, mezquitas, y casas. Las implicaciones de este estudio indican que debemos considerar otros aspectos de una sociedad aparte de su localización costera para determinar su maritimidad. Hay que considerar cómo el mar y sus productos son parte de la vida social y evaluar si existe una influencia recíproca entre el ambiente marítimo y los patrones de organización sociocultural, las prácticas, y las creencias de los Swahili y otras sociedades. [marítimo, pesca y navegación, comercio a larga distancia, Swahili, África Oriental] PMID:25821235

  4. Iodine-131 imaging using 284 keV photons with a small animal CZT-SPECT system dedicated to low-medium-energy photon detection.

    PubMed

    Kojima, Akihiro; Gotoh, Kumiko; Shimamoto, Masako; Hasegawa, Koki; Okada, Seiji

    2016-02-01

    Iodine-131 is widely used for radionuclide therapy because of its β-particle and for diagnostic imaging employing its principal gamma ray. Since that principal gamma ray has the relatively high energy of 364 keV, small animal single-photon emission computed tomography (SPECT) imaging systems may be required to possess the ability to image such higher energy photons. The aim of this study was to investigate the possibility of imaging I-131 using its 284 keV photons instead of its 364 keV photons in a small animal SPECT imaging system dedicated to the detection of low-medium-energy photons (below 300 keV). The imaging system used was a commercially available preclinical SPECT instrument with CZT detectors that was equipped with multi-pinhole collimators and was accompanied by a CT imager. An energy window for I-131 imaging was set to a photopeak of 284 keV with a low abundance compared with 364 keV photons. Small line sources and two mice, one of each of two types, that were injected with NaI-131 were scanned. Although higher counts occurred at the peripheral region of the reconstructed images due to the collimator penetration by the 364 keV photons, the shape of the small line sources could be well visualized. The measured spatial resolution was relatively poor (~1.9 mm for full width at half maximum and ~3.9 mm for full width at tenth maximum). However, a good linear correlation between SPECT values and the level of I-131 radioactivity was observed. Furthermore, the uptake of NaI-131 to the thyroid gland for the two mice was clearly identified in the 3D-SPECT image fused with the X-ray CT image. We conclude that the use of an energy window set on the photopeak of 284 keV and the multi-pinhole collimator may permit I-131 imaging for a preclinical CZT-SPECT system that does not have the ability to acquire images using the 364 keV photons.

  5. Thrombus detection with a radiolabeled antiplatelet monoclonal antibody: Comparison with In-111-oxine technique in coronary and peripheral thrombi in dogs

    SciTech Connect

    Srivastava, S.C.; Esekowitz, M.D.; Meinken, G.E.; Lange, R.C.; Smith, E.; Carbo, P.; Scudder, L.E.; Coller, B.

    1985-05-01

    Platelets (P) labeled with low concentrations of an I-123 or In-111 labeled anti-P monoclonal antibody (7E3) were shown earlier to successfully image in-vivo thrombi. This study was carried out to compare this technique with In-111-oxine-P for localizing coronary and venous thrombi (CT and DVT) in dogs. Thrombi were induced using either transcatheter placement of a dacron pug, mechanical trauma, or electrocoagulation. 7E3 was labeled with I-131 in 70 +- 10% yield (labeling conditions: 100 ..mu..g 7E3; 5 ..mu..g chloramine T; I/sup -//7E3 less than or equal to1; 2 min reaction; 200 ..mu..l pH 7 phosphate buffer; Sp. act. 10-30 ..mu..Ci/..mu..g). Binding of I-131-7E3 to dog P was 75 +- 10% after 1 hr incubation with whole blood. The dogs were injected with 0.5 mCi In-111-oxine-P and 1 mCi I-131-7E3-P in quick succession and data (blood clearance and imaging) were collected for 4 hr. In one experiment, DVT were clearly imaged within 10 min and CT in 30-60 min with I-131-7E3-P. In contrast, In-oxine-P required at least 30 min for imaging DVT and CT were only faintly visualized at 3-4 hr. The DVT to blood and CT to blood ratios at 2.4 hr were 16 and 12.3 for I-131-7E3-P and 9.4 and 6.5 for In-111-oxine-P respectively. In these preliminary studies, I-131-7E3-P thus appears to be superior to In-oxine-P for imaging venous and coronary thrombi. Additionally, 7E3 can be labeled with Tc-99m and I-123 for reduced dose and better imaging properties.

  6. Radioablative therapy with Iodine-131 on a patient with thyroid cancer and chronic renal failure in hemodialysis first experience in Peru

    NASA Astrophysics Data System (ADS)

    Apaza Veliz, D. G.; Herrera Vera, R. D.; Cardenas Abarca, C. A.; Oporto Gonzales, C. A.; Aguilar Ramírez, C.; Vega Ramírez, J. L.; Urquizo Baldomero, R. M.

    2016-07-01

    The Iodine-131 (I-131) is a radioisotope used as a standard treatment for radioablation of thyroid remnants. Among thyroid cancer patients, the ones undergoing hemodialysis represent a specific group. The dose of I-131 is given orally to these patients, part of it is absorbed by the thyroid remnants and the rest of it, largely not incorporated, is excreted primarily by renal excretion. The use of a high dose of radioactivity in the process, and the inability of excretion, represents a high risk of exposure to the patient, medical staff and hemodialysis equipment. This work describes the procedure applied on the radioablation therapy for thyroid cancer while receiving hemodialysis, minimizing the risks for the patient and the staff involved. This clinical procedure will establish the dosimetric measures, a plan on radiation protection and a treatment protocol for this specific type of patients.

  7. Intrathoracic toxic thyroid nodule causing hyperthyroidism with a multinodular normal functional cervical thyroid gland

    PubMed Central

    Serim, Burcu Dirlik; Korkmaz, Ulku; Can, Unal; Altun, Gulay Durmus

    2016-01-01

    Radionuclide scintigraphy with I-131 and Tc-99m pertechnetate (99mTc04) has been widely used in detecting toxic nodules. Intrathoracic goiter usually presents as an anterior mediastinal mass. Mostly the connection between intrathoracic mass and the cervical thyroid gland is clearly and easily identified occurring as a result of inferior extension of thyroid tissue in the neck, which is called as secondary intrathoracic goiter. Completely separated, aberrant or in other words primary intrathoracic goiters arise as a result of abnormal embryologic migration of ectopic thyroid closely associated with aortic sac and descend into the mediastinum. Intrathoracic goiters are generally nontoxic nodules existing with mass effect without causing hyperthyroidism. However, mostly reported cases had enlarged thyroid glands in the neck. This report demonstrates the usefulness of I-131 and 99mTc04 scintigraphy for detecting intrathoracic goiter causing hyperthyroidism with a normal functioned cervical thyroid gland. PMID:27385899

  8. Detection of Fukushima plume within regular Slovenian environmental radioactivity surveillance.

    PubMed

    Glavič-Cindro, D; Benedik, L; Kožar Logar, J; Vodenik, B; Zorko, B

    2013-11-01

    After the Fukushima accident aerosol and rain water samples collected within regular national monitoring programmes were carefully analysed. In rain water samples, aerosol and iodine filters collected in the second half of March and in April 2011 I-131, Cs-134 and Cs-137 were detected. In May 2011 the activities of I-131 and Cs-134 were close or below the detection limit and Cs-137 reached values from the period before the Fukushima accident. Additionally plutonium and americium activity concentrations in aerosol filters were analysed. These measured data were compared with measured data after the Chernobyl contamination in Slovenia in 1986. We can conclude that with adequate regular monitoring programmes influences of radioactivity contamination due to nuclear accidents worldwide can be properly assessed. Copyright © 2013 Elsevier Ltd. All rights reserved.

  9. High-level iodination of monoclonal antibody fragments for radiotherapy

    SciTech Connect

    Ferens, J.M.; Krohn, K.A.; Beaumier, P.L.; Brown, J.P.; Hellstroem, I.; Hellstroem, K.E.; Carrasquillo, J.A.; Larson, S.M.

    1984-03-01

    Two different murine monoclonal antibody Fab fragments specific for p97, a melanoma-associated antigen, were labeled with I-131 at high activity levels without excessive chemical damage. Up to 20 mg of Fab were labeled with up to 300 mCi of I-131 using the chloramine-T method and large working volumes at room temperature. As much as 90% of the initial activity was recovered as labeled product. The labeled Fabs varied in their sensitivity to radioiodination damage, as measured by an in vitro cell-binding assay. Radioiodination was performed safely using a remote iodination apparatus. The final product was of radiopharmaceutical quality suitable for clinical diagnosis and experimental radiotherapy in humans.

  10. The kidney: Imaging with Tc-99m mercaptoacetyltriglycine, a technetium-labeled analog of iodohippurate

    SciTech Connect

    Russell, C.D.; Thorstad, B.L.; Stutzman, M.E.; Yester, M.V.; Fowler, D.; Dubovsky, E.V.

    1989-08-01

    A new renal imaging agent, technetium-99m mercaptoacetyltriglycine (MAG3, mertiatide), is currently undergoing clinical trials. Like iodine-131 orthoiodohippurate (OIH)--and unlike all other available agents--it is avidly secreted by the renal tubules. Fifty patients underwent simultaneous renal imaging studies with I-131 OIH and Tc-99m MAG3. The superior physical properties of the Tc-99m label led to better image quality in all cases, largely due to count rates that were 50-fold better. In two patients, lesions were seen with MAG3 that were not visible with OIH. The biological properties of the two agents were found to be so similar that conventional diagnostic criteria for I-131 OIH could be used for Tc-99m MAG3 with only minor modifications.

  11. Correlation between iodine-131 MIBG imaging and biological markers in advanced neuroblastoma

    SciTech Connect

    Yeh, S.D.; Helson, L.; Benua, R.S.

    1988-01-01

    I-131 metaiodobenzylguanidine (MIBG) imaging was performed in 38 patients with advanced neuroblastoma. Abnormal images were found in patients with elevations of urinary vanillylmandelic acid and dopamine and high serum neuron-specific enolase levels. Normal or minimal elevation of markers was seen in patients with negative images. In follow-up studies after chemotherapy, the disappearance of abnormal uptake was noted in those patients with normal marker values. A persistently abnormal uptake occurred in patients with high marker values. Conversion from a normal image to an abnormal image also occurred in patients whose markers became elevated. I-131 MIBG imaging is sensitive in detecting active foci of a neuroblastoma and is useful in monitoring chemotherapy in these patients.

  12. Radioablative therapy with Iodine-131 on a patient with thyroid cancer and chronic renal failure in hemodialysis first experience in Peru

    SciTech Connect

    Apaza Veliz, D. G.; Herrera Vera, R. D.; Cardenas Abarca, C. A.; Oporto Gonzales, C. A.; Aguilar Ramírez, C.; Urquizo Baldomero, R. M.; Vega Ramírez, J. L.

    2016-07-07

    The Iodine-131 (I-131) is a radioisotope used as a standard treatment for radioablation of thyroid remnants. Among thyroid cancer patients, the ones undergoing hemodialysis represent a specific group. The dose of I-131 is given orally to these patients, part of it is absorbed by the thyroid remnants and the rest of it, largely not incorporated, is excreted primarily by renal excretion. The use of a high dose of radioactivity in the process, and the inability of excretion, represents a high risk of exposure to the patient, medical staff and hemodialysis equipment. This work describes the procedure applied on the radioablation therapy for thyroid cancer while receiving hemodialysis, minimizing the risks for the patient and the staff involved. This clinical procedure will establish the dosimetric measures, a plan on radiation protection and a treatment protocol for this specific type of patients.

  13. Feasibility of an on-line fission-gas-leak detection system

    NASA Technical Reports Server (NTRS)

    Lustig, P. H.

    1973-01-01

    Calculations were made to determine if a cladding failure could be detected in a 100-kW zirconium hydride reactor primary system by monitoring the highly radioactive NaK coolant for the presence of I-131. The system is to be completely sealed. A leak of 0.01 percent from a single fuel pin was postulated. The 0.364-MeV gamma of I-131 could be monitored on an almost continuous basis, while its presence could be varified by using a longer counting time for the 0.638-MeV gamma. A lithium-drifted germanium detector would eliminate radioactive corrosion product interference that could occur with a sodium iodide scintillation detector.

  14. New radionuclide tracers for the diagnosis and therapy of medullary thyroid carcinoma

    SciTech Connect

    Hoefnagel, C.A.; Delprat, C.C.; Zanin, D.; van der Schoot, J.B.

    1988-03-01

    Medullary thyroid carcinoma (MTC), a calcitonin-producing tumor that occurs in familial and sporadic forms, can be monitored satisfactorily with measurements of calcitonin and CEA in serum. However, locating the tumor site may be difficult. In the current review of the experience with four new radionuclide tracers for MTC, the relative value of each of these procedures is outlined. Total body imaging using TI-201 chloride and Tc-99m(V) DMSA are both sensitive techniques that can be used for the detection and follow-up of MTC. Imaging using I-131 MIBG and I-131 anti-CEA antibodies/fragments should be performed once the diagnosis and the tumor site have been established, to evaluate if patients might be amenable for therapy with one of these radiopharmaceuticals.

  15. Serial thyroid iodine content in hyperthyroid patients treated with radioiodine

    SciTech Connect

    Lee, G.S.; Sandler, M.P.; Patton, J.A.; Brill, A.B.

    1986-02-01

    X-ray fluorescent scanning was used to measure initial thyroidal iodine content in 64 patients diagnosed as being hyperthyroid and selected for I-131 therapy, and serially in 48 of these patients after therapy in an attempt to determine those patients that were at high risk of becoming hypothyroid. Iodine content fell rapidly after therapy, reaching a nadir at about three months. Based on the population studied, the chance of early hypothyroidism (within 12 months) is about 80% if the iodine content measured at three months is less than 2 mg. If the iodine content is greater than 2 mg, the chance is only about 14%. The serial measurement of thyroidal iodine content (with x-ray fluorescent scanning) may allow early identification of those patients at high risk of developing permanent hypothyroidism following a therapeutic dose of I-131.

  16. Using public relations strategies to prompt populations at risk to seek health information: the Hanford Community Health Project.

    PubMed

    Thomas, Gregory D; Smith, Stephen M; Turcotte, Joseph A

    2009-01-01

    The Hanford Community Health Project (HCHP) addressed health concerns among "downwinders" exposed to releases of radioactive iodine (I-131) from the Hanford Nuclear Reservation in the 1940s and 1950s. After developing educational materials and conducting initial outreach, HCHP had to decide whether to apply its limited resources to an advertising or public relations approach. The decision to apply public relations strategies was effective in driving awareness of the risk communication message at the community level, reinvigorating the affected community, and ultimately increasing the number of people who sought information about their risk of exposure and related health issues. HCHP used a series of communication tools to reach out to local and regional media, medical and health professionals, and community organizations. The campaign was successful in increasing the number of unique visitors to HCHP Web site and educating and activating the medical community around the releases of I-131 and patient care choices.

  17. A 16-year experience of carotid artery stenting for carotid artery stenosis.

    PubMed

    Nano, Giovanni; Stegher, Silvia; Occhiuto, Maria Teresa; Muzzarelli, Lorenzo; Malacrida, Giovanni; Mazzaccaro, Daniela P

    2016-01-01

    Da più di 50 anni l’endoarteriectomia carotidea (CEA) è stata considerata il trattamento standard per le stenosi carotidee gravi asintomatiche e sintomatiche. Lo stenting carotideo (CAS) è progressivamente emerso negli ultimi 15 anni come alternativa alla chirurgia, specialmente nei pazienti ad alto rischio. Da allora, molti studi clinici randomizzati sono stati pubblicati per valutare la superiorità di un metodo rispetto all’altro, tuttavia i risultati dei trials hanno generato più dubbi che certezze nell’interpretazione dei loro risultati, gravati come sono da diverse limitazioni: la principale riguarda la ridotta competenza endovascolare richiesta per gli operatori che hanno eseguito lo stenting carotideo e partecipato ai trials. Inoltre questi trials sono stati eseguiti circa 10 anni fa, con materiali e farmaci differenti rispetto a quelli usati attualmente. Attualmente i registri su larga scala e le casistiche che riportano risultati a lungo termine sono maggiormente rappresentativi di una esperienza reale, che riflette ciò che accade di routine nella pratica clinica. Nella nostra Unità Operativa di Chirurgia Vascolare, il CAS è stato offerto dal 1999 come alternativa alla CEA per il trattamento delle stenosi carotidee sintomatiche e asintomatiche nei pazienti a rischio moderato-alto. Scopo del nostro lavoro è di riportare la nostra esperienza retrospettiva, con alcuni consigli e suggerimenti che derivano da ciò che abbiamo imparato in più di 16 anni. Abbiamo pertanto raccolto e analizzato retrospettivamente i dati di tutti i pazienti consecutivi che sono venuti per una stenosi carotidea significativa dal 1 ° gennaio 1999 al 31 agosto 2015. I risultati basilari sono stati la mortalità e la morbilità cerebrovascolare maggiore (MCE) sia a 30 giorni che a lungo termine. Lo studio è stato condotto su 1017 pazienti (677 maschi, 66.6%, età media 74 anni, IQR 69-79 anni) trattati sia per stenosi carotidea sintomatica (n=392, 38.5%) che

  18. Breakfast of champions or kiss of death? Survival and sexual performance of protein-fed, sterile Mediterranean fruit flies (Diptera: Tephritidae)

    SciTech Connect

    Yuval, B.; Maor, M.; Levy, K.; Kaspi, R.; Taylor, P.; Shelly, T.

    2007-03-15

    dieta sobre los obstaculos sucesivos que los machos tienen que superar para inseminar las hembras, i.e., unir con otros machos en areas para el apareamiento, copula de las hembras, almacenar esperma e inhibir el re-apareamiento de hembras. Ademas discutimos los efectos de la dieta sobre el exito de su actividad forrajera despues de ser liberados, la longevidad y la habilidad para aguantar la inanicion. Mientras que la alimentacion con proteina universalmente aumentan el exito sexual de los machos naturales, su efecto sobre los machos esteriles varia segun la raza, el lugar de los experimentos y las condiciones ambientales. En algunos casos, los tratamientos que resultaron con mejor desempeno sexual fueron asociados significativamente con el aumento de la vulnerabilidad a la inanicion. Sin embargo, ninguna dieta en particular afecto la habilidad de los machos esteriles para encontrar nutrientes en el campo cuando fueron disponibles. Nosotros sugerimos que puede ser mejor el liberar moscas que tienen una vida relativamente corta y que son mas competidoras, en vez de moscas que tienen una vida larga y sexualmente inefectiva. (author)

  19. The Role of Sex and Mating Status in the Expansion Process of Arhopalus rusticus (Coleoptera: Cerambycidae)-an Exotic Cerambycid in Argentina.

    PubMed

    Grilli, Mariano Pablo; Fachinetti, Romina

    2017-06-01

    ón potencial de esta especie. Utilizamos individuos recolectados de los bosques de pino implantados en la región centro oeste de la provincia de Córdoba (Argentina). La capacidad de dispersión de Arhopalus rusticus se determinó haciendo volar individuos recién emergidos en un molino de vuelo. Se registró el peso previo y posterior al vuelo, el largo del cuerpo y el tamaño del élitro. Las hembras fueron mejores voladoras, más largas, más pesadas, con élitros más largos que los machos. Observamos diferencias entre el potencial de dispersión dependiendo del estado de apareamiento de los individuos. Los individuos apareados volaron más rápido y mayores distancias que los individuos no apareados y consumieron una menor fracción de su peso corporal. Se observó una relación positiva entre el tamaño del élitro y la velocidad de vuelo. Se generó un mapa de las distancias de dispersión potencial de los machos y de las hembras para la región de estudio utilizando las distribuciones de las distancias obtenidas del molino de vuelo. La dispersión post copulación incrementa las chances de que la especie se establezca en zonas no ocupadas. © The Authors 2017. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  20. 77 FR 37000 - Marine Mammals; File No. 814-1899

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-20

    ....), the regulations governing the taking and importing of marine mammals (50 CFR part 216), the Endangered..., importing, and exporting of endangered and threatened species (50 CFR parts 222-226). The original permit... (Phoca larga), ribbon seal (Phoca fasciata), bowhead whale (Balaena mysticetus), beluga whale...

  1. Molecular fingerprinting of cacao (Theobroma cacao L.) genetic resources in the Dominican Republic

    USDA-ARS?s Scientific Manuscript database

    Cacao (Theobroma cacao L.) is a significant agricultural commodity in the Dominican Republic ranking 11th in the world and number one in organic cacao exports. Dominican cacao genetic resources are maintained, propagated and distributed nationally out of the IDIAF’s Mata Larga research stations. T...

  2. Retrospective Biological Dosimetry at Low and High Doses of Radiation and Radioiodine Impact on Individual Susceptibility to Ionizing Radiation

    PubMed Central

    Cebulska-Wasilewska, Antonina; Krzysiek, Mateusz; Krajewska, Grażyna; Stępień, Artur; Krajewski, Paweł

    2017-01-01

    Iodine-131 (I-131) is often used in thyroid diagnostics and therapy. External and internal exposure to radioiodine can lead to molecular and cellular damage in peripheral blood lymphocytes. The aim of this study was to explore the influence of low and high doses of I-131 on susceptibility to ionizing radiation. Study groups consisted of 30 individuals free of thyroid diseases, 41 patients exposed diagnostically to low doses of I-131, and 37 hyperthyroidism patients exposed therapeutically to high doses. The standardized DNA repair competence assay was used to test the efficacy of the fast DNA repair process in G0 cells. Cytogenetic preparations were made in fresh blood samples before and after challenging cells in vitro with X-ray dose. The frequency of sister chromatid exchanges (SCE) and percentage of cells with significantly elevated numbers of SCE were used as cytogenetic biomarkers associated to homologous recombination and compared to reported earlier cytogenetic biomarkers of cancer risk. Strong individual variation in the biomarkers is observed in all investigated groups before and after challenging. Nevertheless, the efficiency of post challenging fast repair is significantly high in the patients exposed to diagnostic I-131 doses than in unexposed control group and linked to decreased cytogenetic damage. However, 5 weeks after administration of therapeutic doses, significant increases of unrepaired post challenging DNA and cytogenetic damages were observed indicating a health risk. Results also suggest that the appearance of cancers in immediate families might influence DNA repair differently in patients exposed to low than to high doses. PMID:28250909

  3. Analysis of thyroid malignant pathologic findings identified during 3 rounds of screening (1997-2008) of a cohort of children and adolescents from belarus exposed to radioiodines after the Chernobyl accident.

    PubMed

    Zablotska, Lydia B; Nadyrov, Eldar A; Rozhko, Alexander V; Gong, Zhihong; Polyanskaya, Olga N; McConnell, Robert J; O'Kane, Patrick; Brenner, Alina V; Little, Mark P; Ostroumova, Evgenia; Bouville, Andre; Drozdovitch, Vladimir; Minenko, Viktor; Demidchik, Yuri; Nerovnya, Alexander; Yauseyenka, Vassilina; Savasteeva, Irina; Nikonovich, Sergey; Mabuchi, Kiyohiko; Hatch, Maureen

    2015-02-01

    Recent studies of children and adolescents who were exposed to radioactive iodine-131 (I-131) after the 1986 Chernobyl nuclear accident in Ukraine exhibited a significant dose-related increase in the risk of thyroid cancer, but the association of radiation doses with tumor histologic and morphologic features is not clear. A cohort of 11,664 individuals in Belarus who were aged ≤18 years at the time of the accident underwent 3 cycles of thyroid screening during 1997 to 2008. I-131 thyroid doses were estimated from individual thyroid activity measurements taken within 2 months after the accident and from dosimetric questionnaire data. Demographic, clinical, and tumor pathologic characteristics of the patients with thyroid cancer were analyzed using 1-way analysis of variance, chi-square tests or Fisher exact tests, and logistic regression. In total, 158 thyroid cancers were identified as a result of screening. The majority of patients had T1a and T1b tumors (93.7%), with many positive regional lymph nodes (N1; 60.6%) but few distant metastases (M1; <1%). Higher I-131 doses were associated with higher frequency of solid and diffuse sclerosing variants of thyroid cancer (P < .01) and histologic features of cancer aggressiveness, such as lymphatic vessel invasion, intrathyroidal infiltration, and multifocality (all P < .03). Latency was not correlated with radiation dose. Fifty-two patients with self-reported thyroid cancers which were diagnosed before 1997 were younger at the time of the accident and had a higher percentage of solid variant cancers compared with patients who had screening-detected thyroid cancers (all P < .0001). I-131 thyroid radiation doses were associated with a significantly greater frequency of solid and diffuse sclerosing variants of thyroid cancer and various features of tumor aggressiveness. © 2014 American Cancer Society.

  4. Analysis of thyroid malignant pathological findings identified during three rounds of screening (1997-2008) of a Belarusian cohort of children and adolescents exposed to radioiodines after the Chernobyl accident

    PubMed Central

    Zablotska, Lydia; Nadyrov, Eldar; Rozhko, Alexander; Gong, Zhihong; Polyanskaya, Olga; McConnell, Robert; O'Kane, Patrick; Brenner, Alina; Little, Mark P.; Ostroumova, Evgenia; Bouville, Andre; Drozdovitch, Vladimir; Minenko, Viktor; Demidchik, Yuri; Nerovnya, Alexander; Yauseyenka, Vassilina; Savasteeva, Irina; Nikonovich, Sergey; Mabuchi, Kiyohiko; Hatch, Maureen

    2015-01-01

    Background Recent studies of children and adolescents exposed to radioactive iodine-131 (I-131) after the 1986 Chernobyl nuclear accident in Ukraine showed significant dose-related increase in the risk of thyroid cancer, but the association of radiation doses with tumor histological and morphological features is not clear. Methods A cohort of 11,664 individuals in Belarus ≤18 years at the time of the accident underwent three cycles of thyroid screening in 1997-2008. I-131 thyroid doses were estimated from individual thyroid activity measurements taken within two months after the accident and dosimetric data from questionnaires. Demographic, clinical and pathological characteristics of thyroid cancer cases were analyzed using one-way analysis of variance, chi-square or Fisher's exact tests, and logistic regression. Results As a result of screening, 158 thyroid cancers were identified. The majority of cases had T1a and T1b tumors (93.7%), with many regional N1 (60.6%) but few distant M1 (<1%) metastases. Higher I-131 doses were associated with higher frequency of solid or diffuse sclerosing variants of thyroid cancer (P<0.01) and histological features of cancer aggressiveness, such as lymphatic vessel invasion, intrathyroidal infiltration, and multifocality (all P<0.03). Latency was not correlated with radiation dose. Fifty-two cases of self-reported thyroid cancers diagnosed prior to 1997 were younger at the time of the accident and had a higher percentage of solid variant cancers compared to screening-detected cases (all P<0.0001). Conclusions I-131 thyroid radiation doses were associated with significantly higher frequency of solid or diffuse sclerosing variants of thyroid cancer and various features of tumor aggressiveness. PMID:25351557

  5. Prevalence of Hyperthyroidism Following Exposure During Childhood or Adolescence to Radioiodines from the Chornobyl Nuclear Accident: Dose-Response Results from the Ukrainian-American Cohort Study

    PubMed Central

    Hatch, M.; Furukawa, K.; Brenner, A.; Olinjyk, V.; Ron, E.; Zablotska, L.; Terekhova, G.; McConnell, R.; Markov, V.; Shpak, V.; Ostroumova, E.; Bouville, A.; Tronko, M.

    2013-01-01

    Relatively few data are available on the prevalence of hyperthyroidism (TSH concentrations of < 0.3 mIU/L, with normal or elevated concentrations of free T4) in individuals exposed to radioiodines at low levels. The accident at the Chornobyl (Chernobyl) nuclear plant in Ukraine on April 26, 1986 exposed large numbers of residents to radioactive fallout, principally to iodine-131 (I-131) (mean and median doses = 0.6 Gray (Gy) and 0.2 Gy). We investigated the relationship of I-131 and prevalent hyperthyroidism among 11,853 individuals exposed as children or adolescents in Ukraine who underwent an in-depth, standardized thyroid gland screening examination 12–14 years later. Radioactivity measurements taken shortly after the accident were available for all subjects and were used to estimate individual thyroid doses. We identified 76 cases of hyperthyroidism (11 overt, 65 subclinical). Using logistic regression, we tested a variety of continuous risk models and conducted categorical analyses for all subjects combined and for females (53 cases, n=5,767) and males (23 cases, n=6,086) separately, but found no convincing evidence of a dose response relationship between I-131 and hyperthyroidism. There was some suggestion of elevated risk among females in an analysis based on a dichotomous dose model with a threshold of 0.5 Gy chosen empirically (OR=1.86, P=0.06), but the statistical significance level was reduced (P=0.13) in a formal analysis with an estimated threshold. In summary, after a thorough exploration of the data, we found no statistically significant dose response relationship between individual I-131 thyroid doses and prevalent hyperthyroidism. PMID:21128800

  6. Iodine-131 tositumomab (Bexxar) in a radiation oncology environment

    SciTech Connect

    Macklis, Roger M. . E-mail: macklir@ccf.org

    2006-10-01

    Iodine-131 (I-131) tositumomab (Bexxar; GlaxoSmithKline, Research Triangle Park, NC) is one of two recently approved radiolabeled antibodies directed against the CD20 surface antigen found on normal B cells and in more than 95% of B cell non-Hodgkin's lymphoma. The compound itself is formulated as an IgG2a immunoglobulin radiolabeled with the mixed beta/gamma emitter I-131. Multicenter clinical trials have repeatedly shown impressive clinical responses (20-40% complete response rates and 60-80% overall response rates) in the patient groups for whom this treatment is indicated. Treatment-related toxicity is generally extremely mild and typically involves only reversible hematopoietic suppression and (in some cases) a risk of treatment-induced hypothyroidism. Owing to Radiation safety concerns necessitated by the clinical use of this targeted radiopharmaceutical, it is important for radiation oncology departments wishing to participate in the care of these patients to establish methodologies and standard operating procedures for safe and efficient departmental use. This summary reviews the pertinent background information related to the current clinical experience with I-131 tositumomab and highlights some of the major opportunities for the participation of radiation oncology in the patient evaluation and treatment process. I-131 tositumomab provides an excellent example of the way in which the increasingly important new field of 'targeted therapy' intersects with the practice of clinical radiotherapy. The author contends that it will be worth the time and effort involved in establishing a firm basis for the development of a comprehensive program for systemic targeted radiopharmaceutical therapies (STaRT) within Radiation medicine domain.

  7. Retrospective evaluation of 131I deposition density and thyroid dose in Poland after the Chernobyl accident.

    PubMed

    Pietrzak-Flis, Zofia; Krajewski, Pawel; Radwan, Irena; Muramatsu, Yasuyuki

    2003-06-01

    The 131I deposition in Poland after the Chernobyl accident on 26 April 1986 was evaluated from the determined 129I deposition and the estimated 129I/131I ratio at the time of the arrival of fallout. Concentrations of 129I and 127I were determined by neutron activation analysis in uncultivated soils from 16 locations in Poland. Determination of 137Cs in soils was carried out by gamma spectrometry. The atomic ratio of 129I/131I at the time of fallout arrival was estimated using the 129I/131I ratio at the time of the accident, which, on the basis of the core inventory data, was assumed to be 22.8. It was estimated from the time of fallout arrival and from the weighed mean atomic ratio that the 129I/131I ratio for Poland was 32.8. The calculated 131I deposition ranged from 63.2 to 729 kBq m(-2). High deposition of 131I occurred in the locations with rainfall but occasionally also in locations without rainfall. Committed equivalent doses from 131I were evaluated for 5-y-old children, 10-y-old children, and adults using the computer model CLRP for the situations with and without countermeasures including iodine prophylaxis. The highest thyroid doses from inhalation and ingestion without countermeasures were 178 mSv, 120 mSv, and 45 mSv for 5-y-old children, 10-y-old children, and adults, respectively. The countermeasures reduced these doses by about 30%.

  8. Thyroid cancer in Graves' disease: is surgery the best treatment for Graves' disease?

    PubMed

    Tamatea, Jade A U; Tu'akoi, Kelson; Conaglen, John V; Elston, Marianne S; Meyer-Rochow, Goswin Y

    2014-04-01

    Graves' disease is a common cause of thyrotoxicosis. Treatment options include anti-thyroid medications or definitive therapy: thyroidectomy or radioactive iodine (I(131) ). Traditionally, I(131) has been the preferred definitive treatment for Graves' disease in New Zealand. Reports of concomitant thyroid cancer occurring in up to 17% of Graves' patients suggest surgery, if performed with low morbidity, may be the preferred option. The aim of this study was to determine the rate of thyroid cancer and surgical outcomes in a New Zealand cohort of patients undergoing thyroidectomy for Graves' disease. This study is a retrospective review of Waikato region patients undergoing thyroid surgery for Graves' disease during the 10-year period prior to 1 December 2011. A total of 833 patients underwent thyroid surgery. Of these, 117 were for Graves' disease. Total thyroidectomy was performed in 82, near-total in 33 and subtotal in 2 patients. Recurrent thyrotoxicosis developed in one subtotal patient requiring I(131) therapy. There were two cases of permanent hypoparathyroidism and one of permanent recurrent laryngeal nerve palsy. Eight patients (6.8%) had thyroid cancer detected, none of whom had overt nodal disease. Five were papillary microcarcinomas (one of which was multifocal), two were papillary carcinomas (11 mm and 15 mm) and one was a minimally invasive follicular carcinoma. Thyroid cancer was identified in approximately 7% of patients undergoing surgery for Graves' disease. A low complication rate (<2%) of permanent hypoparathyroidism and nerve injury (<1%) supports surgery being a safe alternative to I(131) especially for patients with young children, ophthalmopathy or compressive symptoms. © 2012 The Authors. ANZ Journal of Surgery © 2012 Royal Australasian College of Surgeons.

  9. Intercomparisons for quality assurance of activity measurements with radionuclide calibrators

    NASA Astrophysics Data System (ADS)

    Debertin, K.; Schrader, H.

    1992-02-01

    Several intercomparisons with up to 82 participants have been organized in order to obtain information on the quality of activity measurements of radiopharmaceuticals with radionuclide calibrators ("activimeters") in nuclear medicine. The following radionuclides were chosen: 99mTc, 99mTc(99.9%) + 99Mo(0.1%), 123I, 131I and 201Tl. The error limits given in the European Pharmacopoeia were exceeded in about one third of the reported activity values.

  10. Participation of the hypophyseal-adrenal cortex system in thrombin clearance during immobilization stress

    NASA Technical Reports Server (NTRS)

    Kudryashov, B. A.; Uljanov, A. M.; Shapiro, F. B.; Bazazyan, G. G.

    1981-01-01

    Thrombin marked with I-131 resulted in a considerable increase of the thrombined clearance rate in healthy male rats during stress caused by an immobilization lasting 30 minutes, and in an increase of thrombin clearance occurred by a combination of immobilization and administration of adrenocorticotropin (ACTH). Contrary to ACTH, the thrombin clearance is not stimulated in healthy animals by hydrocortisone. The results of the examination are presented.

  11. Indium-111 labeled monoclonal antibodies (Ab): The effect of DTPA conjugation on the Ab activity and tissue distribution

    SciTech Connect

    Sakahara, H.; Endo, K.; Nakashima, T.; Ohta, H.; Okada, K.; Yoshida, O.; Ohmomo, Y.; Horiuchi, K.; Yokoyama, A.; Torizuka, K.

    1984-01-01

    Monoclonal antibodies (Ab) to human ..cap alpha..-fetoprotein (AFP) were conjugated with diethylenetriaminepentaacetic acid (DTPA) using cyclic DTPA anhydride and the obtained conjugates, DTPA-Ab, were labeled with In-111. The effect of DTPA conjugation on the affinity constant and the maximum binding capacity of Ab was evaluated by radioimmunoassay and Scatchard plot analysis and In-111 labeled DTPA-Ab were used for the radioimmunodetection of tumor. Ab containing 1.0 DTPA molecule per Ab showed almost full retention of both the affinity constant and the maximum binding capacity. Then, 40 ..mu..Ci of In-111 labeled DTPA-Ab were injected intravenously to nude mice bearing AFP-producing human testicular tumor and the resulted were compared with I-131 labeled Ab. Scintigraphy clearly revealed transplanted tumor. Localization of In-111 labeled DTPA-Ab was significantly higher than I-131 labeled Ab. Tumor to blood ratio obtained at 4 days after injection was 2.59 with In-111 labeled DTPA-Ab compared to 0.99 with I-131 labeled Ab. When more than 1.9 DTPA molecules were incorporated per Ab, the maximum binding capacity decreased, although the affinity constant was less affected. These In-111 labeled DTPA-Ab caused significantly higher liver accumulation. These results indicate that In-111 labeled DTPA-Ab at a cojugated DTPA to Ab molar ratio of 1.0 may be superior to I-131 labeled Ab for tumor imaging, but the maximum binding capacity and tissue distribution of In-111 labeled DTPA-AB are greatly dependent upon the number of DTPA molecules incorporated per Ab molecule.

  12. Iodine-131 Therapy and Lacrimal Drainage System Toxicity: Nasal Localization Studies Using Whole Body Nuclear Scintigraphy and SPECT-CT.

    PubMed

    Ali, Mohammad Javed; Vyakaranam, Achyut Ram; Rao, Jyotsna Eleshwarapu; Prasad, Giri; Reddy, Palkonda Vijay Anand

    The objective of this study was to evaluate the influence of dose on nasal localization of radioactive iodine-131 (I-131) following therapy for differentiated thyroid carcinomas. Retrospective evaluation of all patients who underwent post-therapy I-131 whole body scintigraphy and single photon emission computed tomography was performed. Patients were divided into 2 groups; group A were treated with 100 millicurie (mCi) and group B with ≥150 mCi. Databases were reviewed for demographics, diagnosis, and administered dosage of I-131. Whole body scintigraphy images were retrieved and nasal uptake was analyzed and classified as nil to trace, low, moderate, and high uptake and corresponding single photon emission CTs were analyzed for radioactive nasal activity. A total of 100 patients were studied, 50 in each of the groups. The M:F ratio was 1.1:1 (27:23) in group A and 1.5:1 (30:20) in group B. The mean age was 43.12 years and 54.6 years in groups A and B, respectively. Papillary carcinoma of the thyroid was the most common type accounting for 82% (41/50) of patients in group A and 62% (31/50) in group B. Imaging studies revealed nil to trace nasal activity in 80% (40/50) in group A as compared with 56% (28/50) in group B. None of the patients in group A showed high nasal uptake, whereas 4% (2/50) in group B demonstrated such high activity. Intranasal localization of radioactive I-131 was significant in patients receiving a dose of ≥150 mCi. Intranasal localization may partly explain toxicity to nasolacrimal duct and may be a risk factor for subsequent development of nasolacrimal duct obstructions.

  13. Avid thyroid uptake of (Tc-99m) sodium pertechnetate in children with goitrous cretinism

    SciTech Connect

    Kim, E.E.; Domstad, P.A.; Choy, Y.C.; DeLand, F.H.

    1981-07-01

    Three children with goitrous hypothyroidism had thyroid scans with (Tc-99m) sodium pertechnetate, which showed symmetrically enlarged thyroid glands with uniformly increased activities compared to little activities in the salivary glands and low body background activities. These scan findings, simulating those of Graves' disease, reflect acid trapping of this tracer, analogous to that seen with I-131. Perchlorate discharge test was positive in two patients, indicating an organification defect.

  14. A phase I/II trial of iodine-131-tositumomab (anti-CD20), etoposide, cyclophosphamide, and autologous stem cell transplantation for relapsed B-cell lymphomas

    SciTech Connect

    Press, O. W.; Eary, Janet F.; Gooley, T; Gopal, A K.; Liu, Stephen; Rajendran, Joseph G.; Maloney, David G.; Petersdorf, Stephen; Bush, Sharon A.; Durack, L. D.; Martin, P J.; Fisher, Darrell R. ); Wood, Brent; Borrow, James W.; Porter, Bruce; Smith, Justin P.; Matthews, D. C.; Appelbaum, F. R.; Bernstein, I. D.

    1999-11-01

    Relapsed B-cell lymphomas are incurable with conventional chemotherapy and radiation therapy, although a fraction of patients can be cured with high-dose chemoradiotherapy and autologous stem-cell transplantation (ASCT). We conducted a phase I/II trial to estimate the maximum tolerated dose (MTD) of iodine 131 (I-131)-tositumomab (anti-CD20 antibody) that could be combined with etoposide and cyclophosphamide followed by ASCT in patients with relapsed B-cell lymphomas. Fifty-two patients received a trace-labeled infusion of 1.7 mg/kg I-131-tositumomab (185-370 MBq) followed by serial quantitative gamma-camera imaging and estimation of absorbed doses of radiation to tumor sites and normal organs. Ten days later, patients received a therapeutic infusion of 1.7 mg/kg tositumomab labeled with an amount of I-131 calculated to deliver the target dose of radiation (20-27 Gy) to critical normal organs (liver, kidneys, and lungs). Patients were maintained in radiation isolation until their total -body radioactivity was less than 0.07 mSv/h at 1 m. They were then given etoposide and cyclophosphamide followed by ASCT. The MTD of I-131-tositumomab that could be safely combined with 60 mg/kg etoposide and 100 mg/kg cyclophosphamide delivered 25 Gy to critical normal organs. The estimated overall survival (OS) and progression-free survival (PFS) of all treated patients at 2 years was 83% and 68%, respectively. These findings compare favorably with those in a nonrandomized control group of patients who underwent transplantation, external-beam total-body irradiation, and etoposide and cyclophosphamide therapy during the same period (OS of 53% and PFS of 36% at 2 years), even after adjustment for confounding variables in a multivariable analysis.

  15. Estimation of thyroid doses and health risks resulting from the intake of radioactive iodine in foods and drinking water by the citizens of Tokyo after the Fukushima nuclear accident.

    PubMed

    Murakami, Michio; Oki, Taikan

    2012-06-01

    The release of radioactive materials from the Fukushima nuclear power plant after the Great East Japan Earthquake on 11 March 2011 poses health risks. In this study, the intake of iodine 131 (I-131) in drinking water and foods (milk, dairy products, and vegetables) by citizens of Tokyo was estimated. The effects of countermeasures (restrictions on the distribution of foods and the distribution of bottled water for infants) on reducing intake were also evaluated. The average thyroid equivalent doses without countermeasures from 21 March 2011 were 0.42 mSv in adults, 1.49 mSv in children, and 2.08 mSv in infants. Those with countermeasures were 0.28, 0.97, and 1.14 mSv respectively, reductions of 33%, 35%, and 45%. Drinking water contributed more to intake by adults and children than foods. The intake of I-131 within the first 2 weeks was more than 80% of the estimated intake, owing to its short half-life, indicating that rapid countermeasures are important in reducing intake. The average risks of cancer incidence and mortality due to I-131 for infants were estimated to be 3×10(-5) and 0.2×10(-5), respectively, lower than the annual risks of traffic accidents, naturally occurring radioactive material (potassium 40), and environmental pollutants such as diesel exhaust particles.

  16. Thyroid doses for evacuees from the Fukushima nuclear accident

    NASA Astrophysics Data System (ADS)

    Tokonami, Shinji; Hosoda, Masahiro; Akiba, Suminori; Sorimachi, Atsuyuki; Kashiwakura, Ikuo; Balonov, Mikhail

    2012-07-01

    A primary health concern among residents and evacuees in affected areas immediately after a nuclear accident is the internal exposure of the thyroid to radioiodine, particularly I-131, and subsequent thyroid cancer risk. In Japan, the natural disasters of the earthquake and tsunami in March 2011 destroyed an important function of the Fukushima Daiichi Nuclear Power Plant (F1-NPP) and a large amount of radioactive material was released to the environment. Here we report for the first time extensive measurements of the exposure to I-131 revealing I-131 activity in the thyroid of 46 out of the 62 residents and evacuees measured. The median thyroid equivalent dose was estimated to be 4.2 mSv and 3.5 mSv for children and adults, respectively, much smaller than the mean thyroid dose in the Chernobyl accident (490 mSv in evacuees). Maximum thyroid doses for children and adults were 23 mSv and 33 mSv, respectively.

  17. Non-invasive measurement of thyroid hormone in feces of a diverse array of avian and mammalian species.

    PubMed

    Wasser, Samuel K; Azkarate, Jurgi Cristòbal; Booth, Rebecca K; Hayward, Lisa; Hunt, Kathleen; Ayres, Katherine; Vynne, Carly; Gobush, Kathleen; Canales-Espinosa, Domingo; Rodríguez-Luna, Ernesto

    2010-08-01

    We developed and validated a non-invasive thyroid hormone measure in feces of a diverse array of birds and mammals. An I(131) radiolabel ingestion study in domestic dogs coupled with High Pressure Liquid Chromatography (HPLC) analysis, showed that peak excretion in feces occurred at 24-48h post-ingestion, with I(131)-labelled thyroid hormone metabolites excreted primarily as triiodothyronine (T3) and relatively little thyroxine (T4), at all excretion times examined. The immunoreactive T3 profile across these same HPLC fractions closely corresponded with the I(131) radioactive profile. By contrast, the T4 immunoreactive profile was disproportionately high, suggesting that T4 excretion included a high percentage of T4 stores. We optimized and validated T3 and T4 extraction and assay methods in feces of wild northern spotted owls, African elephants, howler monkeys, caribou, moose, wolf, maned wolf, killer whales and Steller sea lions. We explained 99% of the variance in high and low T3 concentrations derived from species-specific sample pools, after controlling for species and the various extraction methods tested. Fecal T3 reflected nutritional deficits in two male and three female howler monkeys held in captivity for translocation from a highly degraded habitat. Results suggest that thyroid hormone can be accurately and reliably measured in feces, providing important indices for environmental physiology across a diverse array of birds and mammals. Copyright 2010 Elsevier Inc. All rights reserved.

  18. Scintigraphic portrayal of the syndrome of multiple endocrine neoplasia type-2B

    SciTech Connect

    Yobbagy, J.J.; Levatter, R.; Sisson, J.C.; Shulkin, B.L.; Polley, T.

    1988-06-01

    The scintigraphic appearance of the neoplasms in multiple endocrine neoplasia type 2B (MEN-2B) and the interpretations of the image patterns are described. An 18-year-old male patient with the MEN-2B syndrome underwent TI-201 imaging that showed concentrations of TI-201 in the primary medullary thyroid carcinoma (MTC) tumor and in cervical lymph node metastases. After total thyroidectomy and lymph node dissection, the TI-201 image was normal. Catecholamine levels in the blood and urine were only borderline elevated. Yet, greater than normal concentrations of I-131 metaiodobenzylguanidine (I-131 MIBG) were present in both adrenal glands. Computed tomography of the abdomen showed normal adrenal glands. These results were consistent with the diagnosis of adrenal medullary hyperplasia, a precursor of pheochromocytoma. No operation was indicated to remove the adrenal glands. Imaging with TI-201 appears to be useful in identifying sites of MTC in patients with the MEN-2B syndrome. I-131 MIBG imaging, in conjunction with computed tomography of the adrenal glands and appropriate catecholamine measurements, should be performed in patients with the MEN-2B syndrome to determine the status of the adrenal medullae, which then may be classified as normal, hyperplastic, or tumorous with pheochromocytoma.

  19. Thyroid storm following radioactive iodine (RAI) therapy for pediatric graves disease

    PubMed Central

    Rohrs, Henry J.; Silverstein, Janet H.; Weinstein, David A.; Amdur, Robert J.; Haller, Michael J.

    2014-01-01

    Patient: Female, 11 Final Diagnosis: Thyroid storm Symptoms: Diarrhea • tachycardia • tachypnea • tremor • wheezing Medication: — Clinical Procedure: — Specialty: — Objective: Rare disease Background: A growing number of pediatric endocrinologists treat Graves disease with radioactive iodine (RAI) therapy due to the typically definitive nature of I-131 therapy. Given the published benefits and perceived low risks of RAI when compared to surgery or long-term anti-thyroid medication, the trend towards therapy with RAI is likely to continue. Nevertheless, RAI is not without significant risk. Case Report: An 11-year-old girl with newly diagnosed Graves disease received RAI for definitive treatment of her hyperthyroidism. Within 24 hours of receiving I-131, she developed increasing sleepiness and eventually became unresponsive. Upon arrival at the emergency department she had a tonic-clonic seizure and was diagnosed with thyroid storm. Despite best efforts to manage her hyperthyroidism, she suffered a stroke of the left cerebral hemisphere that left her with persistent neurological deficits. Conclusions: Although thyroid storm after thyroid ablation is rare, the significant morbidity and potential mortality of pediatric thyroid storm warrant further studies to determine if children with markedly elevated thyroid hormone concentrations at diagnosis should receive prolonged pretreatment with anti-thyroid drugs. While such an approach may reduce the efficacy of I-131 ablation, it can also reduce and hopefully eliminate the risk of post-ablative thyroid storm. PMID:24847412

  20. Thyroid doses for evacuees from the Fukushima nuclear accident

    PubMed Central

    Tokonami, Shinji; Hosoda, Masahiro; Akiba, Suminori; Sorimachi, Atsuyuki; Kashiwakura, Ikuo; Balonov, Mikhail

    2012-01-01

    A primary health concern among residents and evacuees in affected areas immediately after a nuclear accident is the internal exposure of the thyroid to radioiodine, particularly I-131, and subsequent thyroid cancer risk. In Japan, the natural disasters of the earthquake and tsunami in March 2011 destroyed an important function of the Fukushima Daiichi Nuclear Power Plant (F1-NPP) and a large amount of radioactive material was released to the environment. Here we report for the first time extensive measurements of the exposure to I-131 revealing I-131 activity in the thyroid of 46 out of the 62 residents and evacuees measured. The median thyroid equivalent dose was estimated to be 4.2 mSv and 3.5 mSv for children and adults, respectively, much smaller than the mean thyroid dose in the Chernobyl accident (490 mSv in evacuees). Maximum thyroid doses for children and adults were 23 mSv and 33 mSv, respectively. PMID:22792439

  1. Thyroid storm following radioactive iodine (RAI) therapy for pediatric graves disease.

    PubMed

    Rohrs, Henry J; Silverstein, Janet H; Weinstein, David A; Amdur, Robert J; Haller, Michael J

    2014-01-01

    Female, 11 FINAL DIAGNOSIS: Thyroid storm Symptoms: Diarrhea • tachycardia • tachypnea • tremor • wheezing - Clinical Procedure: - Specialty: - Rare disease. A growing number of pediatric endocrinologists treat Graves disease with radioactive iodine (RAI) therapy due to the typically definitive nature of I-131 therapy. Given the published benefits and perceived low risks of RAI when compared to surgery or long-term anti-thyroid medication, the trend towards therapy with RAI is likely to continue. Nevertheless, RAI is not without significant risk. An 11-year-old girl with newly diagnosed Graves disease received RAI for definitive treatment of her hyperthyroidism. Within 24 hours of receiving I-131, she developed increasing sleepiness and eventually became unresponsive. Upon arrival at the emergency department she had a tonic-clonic seizure and was diagnosed with thyroid storm. Despite best efforts to manage her hyperthyroidism, she suffered a stroke of the left cerebral hemisphere that left her with persistent neurological deficits. Although thyroid storm after thyroid ablation is rare, the significant morbidity and potential mortality of pediatric thyroid storm warrant further studies to determine if children with markedly elevated thyroid hormone concentrations at diagnosis should receive prolonged pretreatment with anti-thyroid drugs. While such an approach may reduce the efficacy of I-131 ablation, it can also reduce and hopefully eliminate the risk of post-ablative thyroid storm.

  2. [Factors associated with mortality in patients with dysphagia help in making dietary and nutritional choices].

    PubMed

    Ferrero López, María Isabel; De la Rubia Ortí, José Enrique; Castellano Vela, Enrique; González Monte, Carmen; Sanchis-Bayarri Bernal, Vicente; Navarro Sanz, Ramón

    2014-01-01

    Objetivo: Conocer en los pacientes con disfagia ingresados en un Hospital de Media y Larga Estancia, qué factores, valorados al ingreso, están relacionados con fallecer durante su hospitalización y pueden orientar la intervención dietética y nutricional. Material y método: Estudio de cohorte retrospectivo, observacional y descriptivo de pacientes diagnosticados de disfagia por el Método de Exploración Clínica Volumen- Viscosidad (MECVV). Se recogieron variables demográficas y clínicas, estancia, éxitus, revaloraciones de disfagia y tratamientos. Resultados: Se incluyeron 182 pacientes, con edad media de 78 años, fallecieron el 50%. En el análisis univariante se asociaron significativamente con el éxitus: edad >= 85 años, diagnóstico previo de disfagia, padecer enfermedad oncológica, elevada comorbilidad (Charlson entre 2-5 y > 5 puntos), baja funcionalidad previa a hospitalización (Índice de Barthel < 40 puntos), MNA < 17 puntos, albúmina < 3 g/dl, alta puntuación del CONUT (de 5-12 puntos), tratamiento con: opioide, neuroléptico o antidepresivo al realizar el MECVV, y objetivo asistencial al ingreso. En análisis multivariante obtuvieron significación: edad, enfermedad oncológica, comorbilidad, y albúmina como factores de riesgo para fallecer, y llevar antidepresivo como factor protector. Se aplicó análisis de contraste con Curva ROC. El área bajo la curva fue 0,740 y el intervalo de confianza (IC) 0,668-0,811. Conclusiones: En pacientes con disfagia, los datos referidos valorados al ingreso, pueden ayudar a definir más adecuada y precozmente objetivos asistenciales. En los casos con mayor riesgo de fallecer se priorizará una ingesta segura y de confort, y en aquellos con bajo riesgo, además deberá ser eficaz para intentar mejorar al máximo su estado nutricional.

  3. [EFFECTS OF GREEN TEA ON THE NUTRITIONAL STATUS OF THE EXERCISE].

    PubMed

    Albert Pérez, Enrique José; Reig García-Galbis, Manuel

    2015-10-01

    Objetivo: evaluar el efecto del té verde o sus sucedáneos en el estado nutricional de los sujetos que realizan ejercicio físico. Metodología: las palabras clave son: “green tea” AND “exercise”, en cuatro bases de datos documentales: Pubmed, EBSCOHOST, OvidSP y Proquest. Criterios de inclusión (enero de 2010 y diciembre de 2014): edad adulta de la muestra (18-65 años, OMS); consumo de una cantidad cuantificada de té verde o sucedáneos, junto con la realización de ejercicio físico medible en intensidad. Resultados: de 260 artículos, se incluyeron el 5%. En el 69% se trata de estudios con un entrenamiento diseñado, y en el 92% se ha incluido un test de ejercicio para valorar parámetros. El 77% oscilan entre 20-40 años; las muestras varían entre 9 y 36 individuos. El 69% son de larga duración. El GTE ha sido el sucedáneo más utilizado (38%). El 92% de los ensayos han obtenido algún tipo de mejora (en el 92% fue significativa). Conclusiones: se recomienda aumentar las investigaciones sobre la clasificación de los ejercicios. Las mejoras significativas en el estado nutricional de los sujetos por la ingesta del té verde o sucedáneos son: IMC, peso, IGC, MM, INM, OM y MR. El GTE ha sido el que mayores resultados satisfactorios ha proporcionado. No existe homogeneidad en los resultados significativos. Se necesitan realizar nuevos ensayos clínicos. Las diferencias entre los ensayos clínicos revisados reflejan que las mejoras encontradas en el estado nutricional de los sujetos que realizan actividad física deben ser avaladas con nuevas investigaciones. Esto ayudará a crear evidencia en este tipo de aspectos.

  4. Incidental Vocabulary Learning in Second Language Acquisition: A Literature Review (Aprendizaje incidental de vocabulario en la adquisición de una segunda lengua: una revisión de literatura)

    ERIC Educational Resources Information Center

    Restrepo Ramos, Falcon Dario

    2015-01-01

    This literature review aims to analyze previous studies that address the incidental learning of vocabulary in second language acquisition. The articles included in this literature review look into the understanding of vocabulary learning through incidental means, the relationship of reading and incidental vocabulary learning, and the strategies…

  5. Peer Interaction: A Social Perspective towards the Development of Foreign Language Learning (Interacción entre pares: una perspectiva social hacia el desarrollo del aprendizaje en una lengua extranjera)

    ERIC Educational Resources Information Center

    Gómez Lobatón, July Carolina

    2011-01-01

    This pedagogical innovation aims at discovering new ways of interaction that go beyond the unidirectional relationship that is presented in the classrooms most of the times. The innovation considers peers to be active agents in the construction of knowledge and proposes new ways to arrange groups in the classroom so that the arrangement can…

  6. La Migracion Como Una Transicion Critica para la Persona en Su Ambiente. Una Interpretacion Organismico Evolutiva. (Migration as a Critical Person-in-Environment Transition: An Organismic-Developmental Interpretation.)

    ERIC Educational Resources Information Center

    Pacheco, Angel M.; And Others

    In order to explore some of the changes and stresses connected with migration and return migration, a study was conducted among migrants returning from the United States mainland to Puerto Rico. The sample consisted of 75 adolescents participating in a Bilingual Education program in Puerto Rico. Data were collected using Psychological Distance…

  7. Por Que Mami No Puede Cambiar una Goma? Tercer Modulo de una Serie para Maestros de Escuela Elemental. (Why Can't Mommy Change a Flat Tire? Third Module of a Series for Elementary School Teachers).

    ERIC Educational Resources Information Center

    Molina, Carmen Eneida, Ed.; And Others

    This guide for teachers, in English and Spanish, examines the role parents play in the socialization of sex roles. A pre-test and post test are included to measure the user's awareness of sexual stereotyping. Five object lessons cover the following topics: (1) stereotypes which exist prior to a baby's birth; (2) behavioral standards on which…

  8. La Migracion Como Una Transicion Critica para la Persona en Su Ambiente. Una Interpretacion Organismico Evolutiva. (Migration as a Critical Person-in-Environment Transition: An Organismic-Developmental Interpretation.)

    ERIC Educational Resources Information Center

    Pacheco, Angel M.; And Others

    In order to explore some of the changes and stresses connected with migration and return migration, a study was conducted among migrants returning from the United States mainland to Puerto Rico. The sample consisted of 75 adolescents participating in a Bilingual Education program in Puerto Rico. Data were collected using Psychological Distance…

  9. Por Que Mami No Puede Cambiar una Goma? Tercer Modulo de una Serie para Maestros de Escuela Elemental. (Why Can't Mommy Change a Flat Tire? Third Module of a Series for Elementary School Teachers).

    ERIC Educational Resources Information Center

    Molina, Carmen Eneida, Ed.; And Others

    This guide for teachers, in English and Spanish, examines the role parents play in the socialization of sex roles. A pre-test and post test are included to measure the user's awareness of sexual stereotyping. Five object lessons cover the following topics: (1) stereotypes which exist prior to a baby's birth; (2) behavioral standards on which…

  10. Una novedosa herramienta estadística para desentrañar las características intrínsecas de una distribución de datos astrofísicos

    NASA Astrophysics Data System (ADS)

    Ferrero, I.; Piatti, A. E.

    The statistical analysis of a sample of data includes the collection; the analysis and the interpretation of them. For example; the construction of histograms has proven to be a powerful tool in statistics; from which it is possible to obtain an overview of the distribution of the data sample considered. In some circumstances; however; the results often depend on the way they are constructed (e.g. size of the bins used; etc.) leading to a variety of possible interpretations. Specifically; this paper presents a statistical method that allows to unravel the intrinsic distribution of a n-dimensional data distribution from "adaptive bins" and the consideration of the errors of the data used. FULL TEXT IN SPANISH

  11. Una Escoba para Ana, Cien Oficios para Juan. Quinto Modulo de una Serie para Maestros de Escuela Elemental. (A Broom for Anna, A Hundred Jobs for John. Fifth Module of a Series for Elementary School Teachers).

    ERIC Educational Resources Information Center

    Molina, Carmen Eneida, Ed.; And Others

    This guide for teachers, in English and Spanish, examines the stereotyped work roles assigned to men and women. The guide examines educational materials that perpetuate these roles and presents teaching alternatives which reinforce students' self esteem and confidence. A pre-test and post-test are included to measure the user's awareness of…

  12. Una Nueva IDEA: Una Guia para Padres acerca de los Cambios en la Ley de Educacion Especial para Ninos con Incapacidades (A New IDEA: A Parent's Guide to the Changes in Social Education Law for Children with Disabilities).

    ERIC Educational Resources Information Center

    Seltzer, Tammy

    This guide for parents, in Spanish, explains the changes in the federal special education law resulting from the 1997 amendments to the Individuals with Disabilities Education Act (IDEA). Changes related to the parent's role in decisions about the child's education and in how schools can discipline special education students are highlighted. A…

  13. [Effects of branched amino acids in endurance sports: a review].

    PubMed

    Salinas-García, María Elia; Martínez-Sanz, José Miguel; Urdampilleta, Aritz; Mielgo-Ayuso, Juan; Norte Navarro, Aurora; Ortiz-Moncada, Rocio

    2014-11-16

    Introducción: El informe emitido por la Agencia Europea de Seguridad Alimentaria (EFSA) en 2010 sobre las declaraciones nutricionales y propiedades saludables, muestra que no existen evidencias científicas que apoyen la suplementación con aminoácidos ramificados (BCAAs). El objetivo de este estudio es analizar los efectos del consumo de suplementos de BCAAs en deportes de larga duración (DLD). Métodos: Estudio descriptivo de revisión bibliográfica sobre el estado actual del efecto del consumo de suplementos de BCAAs. Se realizó una búsqueda en la base de datos PubMed y estrategia de bola de nieve. Criterios de inclusión: Estudios realizados en humanos, ensayos clínicos controlados aleatorizados (ECCA) en castellano/inglés relacionados con el consumo de BCAAs, leucina, valina e isoleucina en DLD y sus efectos sobre el daño muscular, rendimiento deportivo, fatiga central, respuesta anabólica y sistema inmunológico publicados en cualquier país hasta mayo 2014. Resultados: De los 330 estudios identificados, 14 cumplieron los criterios de inclusión. La media de sujetos participantes en los estudio es igual a (11,36 ± 7,43). Sólo dos estudios incluyen un grupo de mujeres. Las disciplinas deportivas que se encontraron en los estudios fueron carrera a pie, ciclismo, combinación ciclismo y carrera a pie, triatlón distancia olímpica y un estudio que incluía 2 grupos de deportistas (triatlón distancia olímpica y carrera a pie). Se estudian los efectos de los BCAAs y daño muscular, rendimiento deportivo, fatiga central, respuesta anabólica en periodo de recuperación y respuesta inmunológica en periodos diferentes del entrenamiento: antes, durante y después o una combinación de éstos. Discusión: Se observa que existe un menor grado de dolor y daño muscular, menor percepción del esfuerzo y fatiga mental, mayor respuesta anabólica en periodo de recuperación y mejora de la respuesta inmunológica cuando se suplementa con BCAAs, no obstante su

  14. Una vision holistica de la educacion superior en contextos posmodernos (The Integrative Conception of Postmodern Higher Education).

    ERIC Educational Resources Information Center

    Zoreda, Margaret Lee; Zoreda-Lozano, Juan Jose

    This paper argues that current "postmodern" conditions demand a rethinking of higher education, especially in countries like Mexico. This would involve the rapprochement of science, technology, and the humanities, based on the belief that the chasm separating them, apart from being artificial, is no longer socially viable. Through a…

  15. Una Guia de Consejos Practicos Sobre la Lectura para los Padres (A Guide to Reading Tips for Parents).

    ERIC Educational Resources Information Center

    Department of Education, Washington, DC.

    The No Child Left Behind program changes the federal role in education by asking America's schools to describe their success in terms of what each student accomplishes. The information in this reading guide, presented in Spanish, was developed by the United States Department of Education to assist parents, caregivers, and teachers in understanding…

  16. INTRODUCCION A UNA COMPARACION FONOLOGICA DEL ESPANOL Y DEL INGLES. (INTRODUCTION TO A PHONOLOGICAL COMPARISON OF SPANISH AND ENGLISH).

    ERIC Educational Resources Information Center

    CARDENAS, DANIEL N.

    A PHONOLOGICAL COMPARISON WAS MADE BETWEEN ENGLISH AND SPANISH. THE PRINCIPAL REFERENCE USED FOR ENGLISH ANALYSIS WAS "AN OUTLINE OF ENGLISH STRUCTURE" BY TRAGER AND SMITH. THE PRINCIPAL REFERENCE USED FOR SPANISH ANALYSIS WAS "SPANISH JUNCTURE AND INTONATION" BY STOCKWELL, BOWEN, AND SILVA-FUENZALIDA. THE PRONUNCIATION PROBLEMS COMMON TO A…

  17. La trama celeste: por qué educar en astronomía. Una oportunidad de aprendizajes múltiples

    NASA Astrophysics Data System (ADS)

    García, B.

    2016-08-01

    Astronomy education at all levels has been an issue addressed by the International Astronomical Union as part of its 2010--2020 plan. The content on astronomical topics are in the curriculum at primary and secondary levels worldwide. Being a cross-discipline, astronomy is also a science that allows to introduce students to the study of the nature in a non-confrontational way: no one is indifferent to their concepts and discoveries. The International Astronomical Union, through its Commission on Education and Development of Astronomy, has implemented, sponsored and carried out over the past five years two special programs, one about didactics of astronomy for teachers of middle level and another one for the transmission of astronomical topics for the disabled. In this presentation, achievements and impact of these programs are shared.

  18. Bienvenido a los Estados Unidos. Una Guia para Refugiados (Welcome to the United States. A Guide for Refugees). First Edition.

    ERIC Educational Resources Information Center

    Economic and Social Research Council, Edinburgh (Scotland). Centre for Educational Sociology.

    This guidebook provides Spanish-speaking refugees being resettled in the United States with general information about what they will encounter and the services they can receive in their first months in the country. This is the Spanish version, and is available in several other languages. The book is distributed to overseas processing agencies,…

  19. Promoviendo una Alimentación Saludable (PAS) design and methods: engaging Latino families in eating disorder treatment.

    PubMed

    Reyes-Rodríguez, Mae Lynn; Bulik, Cynthia M; Hamer, Robert M; Baucom, Donald H

    2013-05-01

    The use of culturally sensitive intervention could improve mental health care for the eating disorder (ED) treatment in the Latino population. The aim of this report is to describe the rationale, design, and methods of the ongoing study entitled "Engaging Latino families in eating disorders treatment." The primary aim of the study is to compare (a) the combined effect of individual cognitive behavioral therapy for bulimia nervosa (CBT-BN) that has been previously adapted for the Latino population plus Family Enhanced (FE) modules, with (b) the standard adapted individual CBT-BN in a proof-of-principle study with 40 Latina adults with eating disorders and one relative or significant other per patient. We hypothesize that 1) the feasibility, acceptability, and adherence of participants in CBT-BN+FE will be superior to individual CBT-BN only; 2) relatives in CBT-BN+FE will report greater treatment satisfaction, greater reduction in family conflict, and greater decreases in caregiver burden than relatives in the individual CBT-BN only condition; and 3) patients who participate in CBT-BN+FE will show trends towards greater decreases in ED symptoms compared with patients in CBT-BN only; although power will be limited to detect this difference. However, we predict that they will show greater retention in treatment, greater treatment satisfaction, and greater decreases in family conflict than patients in CBT-BN only. The completion of this investigation will yield important information regarding the acceptability and feasibility of a culturally sensitive evidence-based treatment model for Latinos with eating disorders.

  20. How To Start a Family Day Care = Como Iniciar una Guarderia en El Hogar. [Videotape and Viewer's Guide].

    ERIC Educational Resources Information Center

    Raphael, Doris; Weisman, Douglas

    Being a family day care provider is work that requires professional responsibilities and attention to the physical, emotional, and educational well-being of children; listening and responding to parents; and running a business. This videotape, in English- and Spanish-language versions, explores the elements involved in starting up a family day…

  1. El Desarrollo Social de los Ninos: Una Lista de Cotejo. ERIC Digest. (Young Children's Social Development: A Checklist. ERIC Digest.)

    ERIC Educational Resources Information Center

    McClellan, Diane E.; Katz, Lilian G.

    The best childhood predictor of later adult adaptation is the adequacy with which a child gets along with other children. Because social development begins in the early years, it is appropriate that early childhood programs include regular formal and informal assessment of children's acquisition of social competence. This digest presents the…

  2. Si Su Hijo cartamudea: Una Guia para los Padres (If Your Child Stutters: A Guide for Parents). Publication No. 15.

    ERIC Educational Resources Information Center

    Speech Foundation of America, Memphis, TN.

    This Spanish language booklet is written for parents who are concerned about the speech of their young child. The goal of the booklet is to enable parents to begin working with their child, and a speech clinician if necessary, with a better understanding of the problem. The booklet discusses common parental questions such as: (1) Does my child…

  3. Hacia una adaptación cultural para el tratamiento de trastornos alimentarios en latinos en Estados Unidos

    PubMed Central

    Reyes-Rodríguez, Mae Lynn; Bulik, Cynthia M.

    2011-01-01

    Eating disorders affect all ethnic and socioeconomic groups. However, evidence based treatments for eating disorders have been developed and tested exclusively on Caucasian populations. With the purpose to develop a culturally sensitive framework for the eating disorders treatment in Latinos/as, the objectives of this work were: 1) identify and describe some of the relevant cultural elements for eating disorders in the Latino population and, 2) to draft a culturally sensitive intervention model for eating disorders in Latino population in the United States. Providing culturally sensitive treatments for Latinos with psychiatric disorders is essential to reverse public health disparities. PMID:22003472

  4. Grasslands of Mexico: A perspective on their conservation (Los pastizales del norte de Mexico: Una perspectiva para su conservacion)

    Treesearch

    Patricia Manzano; Rurik List

    2006-01-01

    Grasslands are areas dominated by grasses and herbs with few or no trees. Grasslands receive too much rain for a desert environment and too little for a forest. Temperate North American grasslands, especially, have undergone changes on a continental level. Their high productivity and fertility, added to their level topography and lack of trees, make them ideal sites...

  5. Puentes hacia una mejor vida (Bridges to a Better Life): Outcome of a Diabetes Control Peer Support Intervention

    PubMed Central

    Ayala, Guadalupe X.; Ibarra, Leticia; Cherrington, Andrea L.; Parada, Humberto; Horton, Lucy; Ji, Ming; Elder, John P.

    2015-01-01

    PURPOSE Peer support can promote diabetes control, yet research on feasible and effective peer support models is lacking. This randomized controlled trial tested a volunteer-based model of peer support for diabetes control. METHODS Thirty-four volunteer peer leaders were recruited and trained to provide support to 5 to 8 patients each through telephone contact, in-person, individual, and group support. Planned dose was 8 contacts, preferably in the first 6 months. Patients with uncontrolled diabetes were randomly sampled from the medical records of 3 community clinics. After a baseline interview and medical records review to obtain baseline values for the primary outcome, HbA1c, 336 patient participants were randomly assigned to a 12-month peer support intervention or usual care. The assessment protocol was repeated at 6 and 12 months after baseline. RESULTS Thirty peer leaders delivered an average of 4 contacts each per assigned participant (range 1–24). Despite the lack of intervention fidelity, the intervention was effective at reducing glycated hemoglobin (HbA1c) among intervention as compared with usual care participants (P=0.05). Similar trends were observed in frequency of meeting fruit and vegetable guidelines (P =0.09), a secondary outcome. Counterintuitively, usual care participants reported checking their feet more days out of 7 than intervention participants (P =0.03). CONCLUSIONS Given the modest changes we observed, combined with other evidence for peer support to promote diabetes control, additional research is needed on how to modify the system of care to increase the level of peer support delivered by volunteers. PMID:26304977

  6. Una prueba empírica de generadores de nümeros pseudoaleatorios mediante un proceso de decaimiento exponencial

    NASA Astrophysics Data System (ADS)

    Coronel-Brizio, H. F.; Hernández-Montoya, A. R.; Jiménez-Montaño, M. A.; Mora-Forsbach, L. E.

    2007-10-01

    Empirical tests for pseudorandom number generators based on the use of processes or physical models have been successfuly used and are considered as complementary to theoretical test of randomness. In this work a statistical methodology for evaluating the quality of pseudorandom number generators is presented. The method is illustrated in the context of the so-called exponential decay process, using some pseudorandom number generators commonly used in physics.

  7. Compartiendo la Ciencia con los Ninos: Una Guia para los Padres (Sharing Science with Children: A Guide for Parents).

    ERIC Educational Resources Information Center

    North Carolina Museum of Life and Science, Durham.

    This guide offers Spanish-speaking parents ways in which they can help their children learn about science at home and in the community. Science is a way of looking at the world. It uses everyday techniques such as observation and classification to give us information about things and how they work. Advice to parents that want to support their…

  8. Una Crisis para la Educacion Bilingue en Nuevo Mexico. (A Crisis for Bilingual Education in New Mexico)

    ERIC Educational Resources Information Center

    Benavides, Ezequiel

    1976-01-01

    Written in Spanish and English, this article briefly reviews the bilingual picture in New Mexico. If New Mexico is to succeed in attracting Federal monies for bilingual education, it must strive for unity in its efforts and objectives. (NQ)

  9. Bienvenido a los Estados Unidos. Una Guia para Refugiados (Welcome to the United States. A Guide for Refugees). First Edition.

    ERIC Educational Resources Information Center

    Economic and Social Research Council, Edinburgh (Scotland). Centre for Educational Sociology.

    This guidebook provides Spanish-speaking refugees being resettled in the United States with general information about what they will encounter and the services they can receive in their first months in the country. This is the Spanish version, and is available in several other languages. The book is distributed to overseas processing agencies,…

  10. Our Treasures: A Celebration of Nebraska's Mexican Heritage = Nuestros Tesoros: Una celebracion de la herencia mexicana de Nebraska.

    ERIC Educational Resources Information Center

    Nebraska State Historical Society, Lincoln.

    This publication is intended as a resource guide for teachers, students, and librarians interested in Mexican American culture, and for groups wishing to conduct local community research using oral histories. The Mexican American Traditions in Nebraska project was designed to document and preserve the richness of Nebraska's Mexican culture. The…

  11. Helping Your Child Learn: A Parent's Guide = Ayudando a Su Hijo a Aprender: Una Guia para los Padres.

    ERIC Educational Resources Information Center

    Cano, Luis R.

    This guide, in English and Spanish, presents ideas for parents to assist their child's progress at school. The contents include ten sections on the following topics: (1) getting started (the importance of attendance and health requirements); (2) report cards; (3) scheduling study time and developing study skills; (4) talking to the teacher; (5)…

  12. Desarrollo de una intervención grupal para la prevención del VIH en parejas heterosexuales.

    PubMed

    Pérez-Jiménez, David; Escabí Montalvo, Aracelis; Del Carmen Cabrera Aponte, María

    2010-01-01

    HIV preventive efforts with heterosexual couples are almost nonexistent. We designed a group intervention based on the Information-Motivation-Behavioral Skills model with the aim of increasing male condom use and promoting the practice of mutual masturbation as a safer sex alternative. We carried out a pilot study with four couples to evaluate the feasibility of the intervention and the aspects of content and format that needed to be modified. Findings reflect that participants were very satisfied with the intervention and they found it entertaining and innovative. They were very comfortable with its format, as well as with the activities. The findings confirm the feasibility of this intervention and the need to direct preventive efforts to this population.

  13. Educacion Ambiental en las Escuelas: Creando una Programa que Funcione! (Environmental Education in the Schools: Creating a Program That Works!).

    ERIC Educational Resources Information Center

    Braus, Judy A.; Wood, David

    This book is a manual that enables teachers to formulate an effective program of environmental education across multiple grade levels and cultural settings. A section provides tips for using the book, followed by nine chapters dealing with different aspects of developing and implementing an environmental education program. Chapter 1 presents a…

  14. Una Nacion En Peligro: La Necesidad Imperiosa de Reformar La Ensenanza. (A Nation at Risk: The Imperative for Educational Reform).

    ERIC Educational Resources Information Center

    National Commission on Excellence in Education (ED), Washington, DC.

    This report: (1) investigates the declining state of the educational system in America, as measured by high school student performance in the United States and other countries; (2) identifies specific problem areas; and (3) offers multiple recommendations for improvement. The five major recommendations arrived at appear, respectively, under the…

  15. Una Crisis para la Educacion Bilingue en Nuevo Mexico. (A Crisis for Bilingual Education in New Mexico)

    ERIC Educational Resources Information Center

    Benavides, Ezequiel

    1976-01-01

    Written in Spanish and English, this article briefly reviews the bilingual picture in New Mexico. If New Mexico is to succeed in attracting Federal monies for bilingual education, it must strive for unity in its efforts and objectives. (NQ)

  16. La Formacion Docente y la Educacion Primaria en Una Propuesta de Cambio (Teacher Training on Education: A Proposal for Change).

    ERIC Educational Resources Information Center

    Fernandez, Enrique Alonso, Ed.

    In order to raise the quality of teaching and teacher education in Uruguay, a program of innovation and change was considered at a 1986 educational conference. Conference goals included identifying ways to: (1) increase opportunities to promote innovation and change; (2) search for strategies to encourage creative problem solving; (3) increase…

  17. Azimut e altezza della Piramide Cestia in una sola osservazione del Sole e dell'ombra proiettata

    NASA Astrophysics Data System (ADS)

    Sigismondi, Costantino

    2016-07-01

    The astronomical azimut and heigth of the Cestia Pyramid in Rome have been measured as 205° and 36 m by observing the alignment of the Sun with the axis and the grazing shadow of the Pyramid on July 22nd.

  18. iPTF 13bvn: La primera evidencia de un progenitor binario para una supernova de tipo Ib

    NASA Astrophysics Data System (ADS)

    Bersten, M. C.; Benvenuto, O. G.; Folatelli, G.; Nomoto, K.

    2015-08-01

    The detection of an object in archival images of the Hubble space telescope at the position of supernova (SN) iPTF 13bvn may be the first direct evidence of a type Ib progenitor. The photometry of this object is compatible with a Wolf-Rayet star with a mass of M. However, hydrodynamical models show that the progenitor would most probably have a mass of M, while masses of the order of 8 M are not possible in the context of those models. We propose an interacting binary system as a progenitor of this SN and perform evolutionary calculations giving rise to a self consistent explanation of the shape of the light curve, the absence of hydrogen, as well as the photometry of the pre-SN. Finally, we present color-magnitude and color-color diagrams that will be useful to discern among the different proposed scenarios when a future detection of this object occurs.

  19. GS118+0144: una supercáscara de H I con contrapartida en el IR medio y lejano

    NASA Astrophysics Data System (ADS)

    Suad, L. A.; Cichowolski, S.; Noriega-Crespo, A.; Arnal, E. M.; Testori, J. C.; Flagey, N.

    2016-08-01

    GS118+0144 is a supershell detected in the neutral hydrogen (H i) emission distribution, centred at ()=(117.7, 1.4) with a systemic velocity of kms, an effective radius of pc, and it is located at a distance of kpc from the Sun. The total gaseous mass associated with the supershell is M, and its kinetic energy is erg. Using mid- and far-infrared data a good morphological coincidence with the H i structure was detected indicating that the dust components coexist with the gas. Carrying out infrared fluxes measurements at different far-infrared bands the dust associated with this structure could be characterized and it was concluded that cool temperatures dominate the area of the supershell.

  20. Ionización en una atmósfera de carbono deficiente en hidrógeno

    NASA Astrophysics Data System (ADS)

    Milone, L. A.; Merlo, D. C.

    Assuming that LTE prevails, the ionization stage was analyzed in the atmosphere of a hydrogen defficient carbon (HdC) star: Y = 0.928, Zc = 0.056, X = 7 × 10-5, and remaining elements in approximately solar abundance (Z = 0.072). It is shown that in the shallower atmospheric layers, electron density in HdC is similar to that found in normal stars (as a consequence of assuming a quite similar metal abundance); in intermediate layers, C is the principal electron-donor, resembling H in normal composition stars, but similarity is not complete, as C is not so abundant in these stars as H is in normal stars (0.70 <= X <= 0.75). In deeper layers, He is the principal electron contributor. These facts, as well as the chemical composition, bring some consequences on the absorption in the stellar atmosphere; in solar composition stars, population II and HdC stars of medium temperature (5000 <= T <= 8000 K), the importance of different absorbers was analyzed. It was found that in the visual region, the absorption in a HdC star atmosphere is smaller than in a normal star. This paper will be published in full elsewhere and further details will be given there.

  1. Intensive Behavioral Intervention for School-Aged Children with Autism: Una Breccia nel Muro (UBM)--A Comprehensive Behavioral Model

    ERIC Educational Resources Information Center

    Fava, Leonardo; Vicari, Stefano; Valeri, Giovanni; D'Elia, Lidia; Arima, Serena; Strauss, Kristin

    2012-01-01

    Although, reviews and outcome research supports empirical evidence for Early Intensive Behavior Intervention in pre-scholars, intensive behavioral service provision for school-aged children with autism spectrum disorders (ASD) are less subject to research studies. In order to provide effective behavioral interventions for school-aged children it…

  2. Distribución superficial de impactos en Iapetus originada por el remanente de una colisión

    NASA Astrophysics Data System (ADS)

    Zoppetti, F. A.; Leiva, A. M.; Briozzo, C. B.

    2015-08-01

    By means of Circular Restricted Three Body Problem Saturn--Iapetus, we analize potential impact distributions on the surface of Iapetus, originated from considering a low-energy population generated as remnants of a collisional event occurred in the past on the surface of this satellite. The results are analized in order to offer a new approach to explain the origin of the albedo dichotomy observed on Iapetus.

  3. Reconnaissance evaluation of Honduran geothermal sites. Una evaluacion por medio de reconocimiento de seis areas geotermicas en Honduras

    SciTech Connect

    Eppler, D.; Fakundiny, R.; Ritchie, A.

    1986-12-01

    Six geothermal spring sites were selected on the basis of preliminary investigations conducted in Honduras over the last decade and were evaluated in terms of their development potential. Of the six, the Platanares and San Ignacio sites have high base temperatures and high surface fluid discharge rates and appear to have the best potential for further development as sources of electrical power. A third site, Azacualpa, has a high enough base temperature and discharge rate to be considered as a back-up, but the logistical problems involved in geophysical surveys make it less attractive than the two primary sites. Of the remaining three sites, Pavana may be a source of direct-use heat for local agricultural processing. Sambo Creek and El Olivar have either severe logistical problems that would impede further investigation and development or base temperatures and flow rates that are too low to warrant detailed investigation at this time.

  4. A Guide for Parents about Retention and Promotion = Una Guia para los Padres de Familia sobre Retencion y Promocion.

    ERIC Educational Resources Information Center

    State Univ. of New York, Oneonta. Coll. at Oneonta. Eastern Stream Center on Resources and Training.

    This bilingual (English and Spanish) brochure explains why retention is common among migrant students and what parents can do to help their children succeed in school. By second grade, nearly 50 percent of migrant students in the nation are older than their classmates and only about 50 percent of migrant students graduate from high school.…

  5. Il volto della Luna da Plutarco a Newton. Storia di una teoria ellenistica della gravità

    NASA Astrophysics Data System (ADS)

    Cappi, Alberto

    2013-03-01

    In his dialogue "De Facie quae in Orbe Lunae apparet", Plutarch includes a discussion on a non-Aristotelian theory of gravity. I describe how this theory could be developed during the Hellenistic period and its influence on the cosmological debate along the centuries until the beginning of modern science. (Text in Italian)

  6. La Traduccion Simultanea como Materia en Una Carrera de Lenguas (Simultaneous Translation as a Course in a Foreign Language Program)

    ERIC Educational Resources Information Center

    Bradley, D.

    1977-01-01

    A description of the foreign language curriculum at the university level in which courses in simultaneous translation are required. The size and composition of the groups are described as well as methods used to develop skill in translating and interpreting. Results are assessed. (Text is in Spanish.) (AMH)

  7. Schoolwide Programs: Parents' Guide & Capacity-Building Materials = Programas Schoolwide: Una Guia para Padres y Materias de Capacitacion.

    ERIC Educational Resources Information Center

    WestEd, San Francisco, CA.

    The reauthorization of Title I (Improving America's Schools Act--IASA) made the Schoolwide Program (Schoolwide) a major strategy for schools with high poverty rates and stressed the importance of parent involvement. This guide was developed to provide professional development and parent education on Schoolwide implementation in California. The…

  8. Si Su Hijo cartamudea: Una Guia para los Padres (If Your Child Stutters: A Guide for Parents). Publication No. 15.

    ERIC Educational Resources Information Center

    Speech Foundation of America, Memphis, TN.

    This Spanish language booklet is written for parents who are concerned about the speech of their young child. The goal of the booklet is to enable parents to begin working with their child, and a speech clinician if necessary, with a better understanding of the problem. The booklet discusses common parental questions such as: (1) Does my child…

  9. Linguistica applicata e glottodidattica: Una collana per insegnanti (Applied Linguistics and Language Teaching: A Series for Teachers).

    ERIC Educational Resources Information Center

    Salvi, Rita

    1988-01-01

    A series on language teaching and learning for teachers includes books on the following topics: (1) psycholinguistics (Titone); (2) the role of the brain in language acquisition (Danesi); (3) the creative language of children (Crema & De Robertis); and (4) suggestopedia (Lozanov & Gateva). (CFM)

  10. Una formalizacion tentativa del problema de la barrera linguistica (A Tentative Formalization of the Problem of Linguistic Barriers).

    ERIC Educational Resources Information Center

    Zierer, Ernesto

    1971-01-01

    The formulas presented in this paper provide the means for showing the ease with which scientific information can be passed from one language into another. The formulas are based on several factors. The linguistic barrier can be measured to illustrate the relative degree of difference between two languages based on a comparison of vocabulary,…

  11. How To Start a Family Day Care = Como Iniciar una Guarderia en El Hogar. [Videotape and Viewer's Guide].

    ERIC Educational Resources Information Center

    Raphael, Doris; Weisman, Douglas

    Being a family day care provider is work that requires professional responsibilities and attention to the physical, emotional, and educational well-being of children; listening and responding to parents; and running a business. This videotape, in English- and Spanish-language versions, explores the elements involved in starting up a family day…

  12. Together! A Newsletter for Parents and Preschoolers = Juntos! Una circular para los Padres y los Pre-Escolares.

    ERIC Educational Resources Information Center

    Tucson Public Library, AZ.

    Designed for parents of preschoolers, this monthly bilingual (English/Spanish) newsletter contains information on local library programs, games and activities to play at home, reading readiness, and recommended books for preschoolers. A feature on disabled children includes a description of the library's special needs collection and a letter to…

  13. Books in Spanish for Children and Young Adults: An Annotated Guide (Libros Infantiles y Juveniles en Espanol: Una Guia Anotada).

    ERIC Educational Resources Information Center

    Schon, Isabel

    Intended to aid teachers, librarians, and others in the selection of Spanish-language books for children in grades K-12, the annotated guide includes books by Hispanic authors which highlight the lifestyle, folklore, heroes, history, fiction, poetry, theatre, and classical literature of Hispanic cultures. Most books included in the guide have been…

  14. Promoviendo una Alimentación Saludable (PAS) Design and Methods: Engaging Latino Families in Eating Disorder Treatment

    PubMed Central

    Reyes-Rodríguez, Mae Lynn; Bulik, Cynthia M.; Hamer, Robert M.; Baucom, Donald H.

    2013-01-01

    The use of culturally sensitive intervention could improve mental health care for the eating disorders treatment in the Latino population. The aim of this report is to describe the rationale, design, and methods of the ongoing study entitled “Engaging Latino families in eating disorders treatment.” The primary aim of the study is to compare (a) the combined effect of individual cognitive behavioral therapy for bulimia nervosa (CBT-BN) that has been previously adapted for the Latino population plus Family Enhanced (FE) modules, with (b) the standard adapted individual CBT-BN in a proof-of-principle study with 40 Latina adults with eating disorders and one relative or significant other per patient. We hypothesize that 1) the feasibility, acceptability, and adherence of participants in CBT-BN+ FE will be superior to individual CBT-BN only; 2) relatives in CBT-BN+ FE will report greater treatment satisfaction, greater reduction in family conflict, and greater decreases in caregiver burden than relatives in the individual CBT-BN only condition; and 3) patients who participate in CBT-BN+ FE will show trends towards greater decreases in ED symptoms compared with patients in CBT-BN only; although power will be limited to detect this difference. However, we predict that they will show greater retention in treatment, greater treatment satisfaction, and greater decreases in family conflict than patients in CBT-BN only. The completion of this investigation will yield important information regarding the acceptability and feasibility of a culturally sensitive evidence-based treatment model for Latinos with eating disorders. (Word Count=240) PMID:23376815

  15. Linguistica applicata e glottodidattica: Una collana per insegnanti (Applied Linguistics and Language Teaching: A Series for Teachers).

    ERIC Educational Resources Information Center

    Salvi, Rita

    1988-01-01

    A series on language teaching and learning for teachers includes books on the following topics: (1) psycholinguistics (Titone); (2) the role of the brain in language acquisition (Danesi); (3) the creative language of children (Crema & De Robertis); and (4) suggestopedia (Lozanov & Gateva). (CFM)

  16. Una formalizacion tentativa del problema de la barrera linguistica (A Tentative Formalization of the Problem of Linguistic Barriers).

    ERIC Educational Resources Information Center

    Zierer, Ernesto

    1971-01-01

    The formulas presented in this paper provide the means for showing the ease with which scientific information can be passed from one language into another. The formulas are based on several factors. The linguistic barrier can be measured to illustrate the relative degree of difference between two languages based on a comparison of vocabulary,…

  17. Estrellas híbridas: una aproximación analítica a temperatura finita

    NASA Astrophysics Data System (ADS)

    Mariani, M.; Orsaria, M.

    2016-08-01

    Starting from the semi-analytic construction of an equation of state which takes into account nuclear and quark matter at finite temperature, we study the possibility that proto-neutron stars, be proto-hybrid stars whose cores are composed of quark matter. We obtain the mass-radius relationship and discuss the latest constraints on masses and radii of neutron stars, considering the pulsars PSR J16142230 and PSR J03480432.

  18. Realidades Latinas: Una Communidad Vibrante Emerge en el Sur de Minneapolis = Latino Realities: A Vibrant Community Emerges in South Minneapolis.

    ERIC Educational Resources Information Center

    HACER: Hispanic Advocacy and Community Empowerment through Research, Minneapolis, MN.

    Findings from a study of the status of Hispanic Americans in South Minneapolis (Minnesota) are presented. Data are from interviews with 34 individuals identified as knowledgeable about the conditions of Latinos in Minneapolis, 4 focus group meetings with an additional 46 community residents, and information from published sources about the size…

  19. Una nueva estimación astrosismológica de la masa del axión

    NASA Astrophysics Data System (ADS)

    Córsico, A. H.; Althaus, L. G.; Romero, A. D.

    G117-B15A and R548 are the two pulsating white dwarf stars more studied within the class of ZZ Ceti variables (atmospheres rich in H). In this work, we present new asteroseismological models for G117-B15A and R548, and employ the rates of period changes with time for the dominant modes of these stars in order to place new constraints on the axion mass. FULL TEXT IN SPANISH

  20. Poblaciones estelares en una región de Carina: detección de estrellas masivas altamente enrojecidas

    NASA Astrophysics Data System (ADS)

    Molina-Lera, J. A.; Gamen, R.; Baume, G. L.; Carraro, G.; Costa, E.

    2016-08-01

    In this work, preliminary results corresponding to a region of the Galaxy close to the direction of the Carina arm are presented. The study was based on deep homogeneous photometric data ( ), obtained in the Inter-American Observatory Cerro Tololo. Data was complemented with 2MASS catalog infrared data, spectral classification of literature and own spectroscopic observations using Gemini. From our photometric analysis of the stars in the area, we could identify three stellar populations. Two of them are linked with young open clusters and the third one is characterized by a consistent set of objects with highly reddened early stars. The spectral types determined, for a sample of these stars, allowed us to confirm this hypothesis, since in all cases they were identified as massive OB type stars.

  1. PREVENCIÓN DEL VIH/SIDA EN LOS CIRCUITOS DE LEVANTE HSH: UNA ASIGNATURA PENDIENTE1

    PubMed Central

    Barreda, Victoria; Carballo-Dieguez, Alex; Marone, Rubén; Balán, Iván; Pando, María Ángeles; Ávila, María Mercedes

    2011-01-01

    Resumen A partir de un relevamiento de tipo etnográfico, se describen lugares de encuentro de HSH en la Ciudad de Buenos Aires y sus prácticas sexuales. El reconocimiento de tales espacios, así como las características que asumen en ellos los encuentros sexuales entre los HSH, plantean obstáculos específicos en la adopción de comportamientos preventivos y, asimismo, generan nuevos desafíos para las actividades de prevención. Se plantean las dificultades y debates conceptuales que la misma categoría presenta, y sus consecuencias en el abordaje preventivo y teórico-metodológico para las ciencias sociales. Además, se proponen nuevos interrogantes acerca de los alcances y las limitaciones del modelo preventivo del VIH/Sida para HSH. PMID:21874154

  2. Desarrollo de una intervención grupal para la prevención del VIH en parejas heterosexuales1

    PubMed Central

    Pérez-Jiménez, David; Escabí Montalvo, Aracelis; del Carmen Cabrera Aponte, María

    2012-01-01

    HIV preventive efforts with heterosexual couples are almost nonexistent. We designed a group intervention based on the Information-Motivation-Behavioral Skills model with the aim of increasing male condom use and promoting the practice of mutual masturbation as a safer sex alternative. We carried out a pilot study with four couples to evaluate the feasibility of the intervention and the aspects of content and format that needed to be modified. Findings reflect that participants were very satisfied with the intervention and they found it entertaining and innovative. They were very comfortable with its format, as well as with the activities. The findings confirm the feasibility of this intervention and the need to direct preventive efforts to this population. PMID:23847716

  3. Una Mejor Opportunidad para Aprender: La Educacion Bilingue Bicultural (A Better Chance to Learn: Bilingual-Bicultural Education).

    ERIC Educational Resources Information Center

    Commission on Civil Rights, Washington, DC.

    The effectiveness of bilingual bicultural education as a means of increasing the opportunities of language minority students is examined in this report, which is addressed to educators and the general public. First, an introduction defines key terms, briefly outlines controversies which surround bilingual education, and describes the contents of…

  4. Helping Your Child Learn: A Parent's Guide = Ayudando a Su Hijo a Aprender: Una Guia para los Padres.

    ERIC Educational Resources Information Center

    Cano, Luis R.

    This guide, in English and Spanish, presents ideas for parents to assist their child's progress at school. The contents include ten sections on the following topics: (1) getting started (the importance of attendance and health requirements); (2) report cards; (3) scheduling study time and developing study skills; (4) talking to the teacher; (5)…

  5. Hacia una adaptación cultural para el tratamiento de trastornos alimentarios en latinos en Estados Unidos.

    PubMed

    Reyes-Rodríguez, Mae Lynn; Bulik, Cynthia M

    2010-01-01

    Eating disorders affect all ethnic and socioeconomic groups. However, evidence based treatments for eating disorders have been developed and tested exclusively on Caucasian populations. With the purpose to develop a culturally sensitive framework for the eating disorders treatment in Latinos/as, the objectives of this work were: 1) identify and describe some of the relevant cultural elements for eating disorders in the Latino population and, 2) to draft a culturally sensitive intervention model for eating disorders in Latino population in the United States. Providing culturally sensitive treatments for Latinos with psychiatric disorders is essential to reverse public health disparities.

  6. Intensive Behavioral Intervention for School-Aged Children with Autism: Una Breccia nel Muro (UBM)--A Comprehensive Behavioral Model

    ERIC Educational Resources Information Center

    Fava, Leonardo; Vicari, Stefano; Valeri, Giovanni; D'Elia, Lidia; Arima, Serena; Strauss, Kristin

    2012-01-01

    Although, reviews and outcome research supports empirical evidence for Early Intensive Behavior Intervention in pre-scholars, intensive behavioral service provision for school-aged children with autism spectrum disorders (ASD) are less subject to research studies. In order to provide effective behavioral interventions for school-aged children it…

  7. Books in Spanish for Children and Young Adults: An Annotated Guide (Libros Infantiles y Juveniles en Espanol: Una Guia Anotada).

    ERIC Educational Resources Information Center

    Schon, Isabel

    Intended to aid teachers, librarians, and others in the selection of Spanish-language books for children in grades K-12, the annotated guide includes books by Hispanic authors which highlight the lifestyle, folklore, heroes, history, fiction, poetry, theatre, and classical literature of Hispanic cultures. Most books included in the guide have been…

  8. La Formacion Docente y la Educacion Primaria en Una Propuesta de Cambio (Teacher Training on Education: A Proposal for Change).

    ERIC Educational Resources Information Center

    Fernandez, Enrique Alonso, Ed.

    In order to raise the quality of teaching and teacher education in Uruguay, a program of innovation and change was considered at a 1986 educational conference. Conference goals included identifying ways to: (1) increase opportunities to promote innovation and change; (2) search for strategies to encourage creative problem solving; (3) increase…

  9. Personal Safety for Children: A Guide for Parents = Una guia para los padres sobre la seguridad personal de los ninos.

    ERIC Educational Resources Information Center

    Department of Justice, Washington, DC.

    Noting that parents and teachers have the responsibility of safeguarding children and teaching them the skills they need to be safe, this pamphlet, in Spanish and English versions, is designed to help parents talk to their children about how to protect themselves against abduction and exploitation. The pamphlet is organized into six sections.…

  10. Schoolwide Programs: Parents' Guide & Capacity-Building Materials = Programas Schoolwide: Una Guia para Padres y Materias de Capacitacion.

    ERIC Educational Resources Information Center

    WestEd, San Francisco, CA.

    The reauthorization of Title I (Improving America's Schools Act--IASA) made the Schoolwide Program (Schoolwide) a major strategy for schools with high poverty rates and stressed the importance of parent involvement. This guide was developed to provide professional development and parent education on Schoolwide implementation in California. The…

  11. Seizures, cysticercosis and rural-to-urban migration: the PERU MIGRANT study

    PubMed Central

    Gonzales, Isidro; Miranda, J Jaime; Rodriguez, Silvia; Vargas, Victor; Cjuno, Alfredo; Smeeth, Liam; Gonzalez, Armando E; Tsang, Victor C W; Gilman, Robert H; Garcia, Hector H

    2015-01-01

    équences neurologiques de l'infection par la cysticercose sont susceptibles de survivre à la réponse d'anticorps durant des années après la migration des zones rurales vers les zones urbaines. Objetivos Examinar la prevalencia de convulsiones, epilepsia, y seropositividad para cisticercosis entre población rural (de zonas endémicas para cisticercosis), inmigrantes provenientes de zonas rurales a tugurios urbanos no endémicos, y habitantes urbanos de los mismo tugurios urbanos no endémicos. Métodos Se estudiaron tres poblaciones peruanas (n=985) originalmente reclutadas en un estudio de enfermedades crónicas y migración. Estos grupos incluían habitantes rurales de una región endémica (n=200), inmigrantes de larga duración de zonas rurales a urbanas (n=589), e individuos que vivían en la misma zona urbana (n=196). Las convulsiones se detectaron mediante una encuesta y un neurólogo examinó a quienes habían respondido positivamente. Se procesaron muestras de suero de 981/985 individuos en busca de anticuerpos para cisticercosis mediante inmunoblot. Resultados La prevalencia de epilepsia (por 1,000 personas) era de 15.3 en el grupo urbano, 35.6 en inmigrantes y 25 en habitantes rurales. Se observó un gradiente en la seroprevalencia de los anticuerpos para cisticercosis: grupos urbano 2%, inmigrante 13.5% y rural 18% (p<0.05). Se observó un patrón de aumento similar de mayor seroprevalencia entre inmigrantes según la edad que tenían en el momento de emigrar. En pobladores rurales, había una evidencia importante de asociación entre tener una serología positiva y sufrir convulsiones (p=0.011), pero esta asociación no se observaba en inmigrantes de larga duración o residentes urbanos. En la población al completo, comparada con los participantes seronegativos, aquellos con una fuerte reactividad de anticuerpos (≥4 bandas de anticuerpos) tenían una mayor probabilidad de sufrir epilepsia (p<0.001). Conclusiones No solo la migración internacional afecta la

  12. Biogeochemical responses to nutrient inputs in a Cuban coastal lagoon: runoff, anthropogenic, and groundwater sources.

    PubMed

    González-De Zayas, R; Merino-Ibarra, M; Soto-Jiménez, M F; Castillo-Sandoval, F S

    2013-12-01

    Laguna Larga, a coastal lagoon in central Cuba, has been heavily altered by tourism infrastructure construction and sewage disposal. We hypothesize that this has decreased the circulation and caused eutrophication of the lagoon. To assess this, 12 bimonthly samplings were carried out in 2007-2008. Temperature, salinity, oxygen, nutrients and nitrogen, and phosphorous fractions (inorganic, organic, and total) were determined. Water and salt budgets, as well as biogeochemical fluxes of nitrogen and phosphorus were calculated using the LOICZ budget model for the three sections of the lagoon identified by morphological constrains and salinity patterns. Laguna Larga is a choked lagoon with restricted water circulation, low exchange, and high residence times that vary significantly along its sections. Residence time was estimated to be 0.1-0.7 years for the inner section and 1-9 days for the outer one. High levels of total nitrogen (annual means 126-137 μM, peaks up to 475 μM) and phosphorus (2.5-4.4 μM, peaks up to 14.5 μM) are evidence of eutrophication of Laguna Larga. During 2007, an average precipitation year, Laguna Larga exported water (703 m(3) d(-1)) and was a source of nitrogen (9.026 mmol m(-2) d(-1)) and phosphorus (0.112 mmol m(-2) d(-1)) to the adjacent sea. δ(15)N determinations in the seagrass Thalassia testudinum (-1.83 to +3.02 ‰) differed significantly between sites in the lagoon and offshore reference sites located W of the inlet, but were similar to those located E of the inlet. δ(15)N determinations in the seaweed Penicillus dumetosus (+1.02 to +4.2) did not show significant differences.

  13. Monte Carlo verification of polymer gel dosimetry applied to radionuclide therapy: a phantom study.

    PubMed

    Gear, J I; Charles-Edwards, E; Partridge, M; Flux, G D

    2011-11-21

    This study evaluates the dosimetric performance of the polymer gel dosimeter 'Methacrylic and Ascorbic acid in Gelatin, initiated by Copper' and its suitability for quality assurance and analysis of I-131-targeted radionuclide therapy dosimetry. Four batches of gel were manufactured in-house and sets of calibration vials and phantoms were created containing different concentrations of I-131-doped gel. Multiple dose measurements were made up to 700 h post preparation and compared to equivalent Monte Carlo simulations. In addition to uniformly filled phantoms the cross-dose distribution from a hot insert to a surrounding phantom was measured. In this example comparisons were made with both Monte Carlo and a clinical scintigraphic dosimetry method. Dose-response curves generated from the calibration data followed a sigmoid function. The gels appeared to be stable over many weeks of internal irradiation with a delay in gel response observed at 29 h post preparation. This was attributed to chemical inhibitors and slow reaction rates of long-chain radical species. For this reason, phantom measurements were only made after 190 h of irradiation. For uniformly filled phantoms of I-131 the accuracy of dose measurements agreed to within 10% when compared to Monte Carlo simulations. A radial cross-dose distribution measured using the gel dosimeter compared well to that calculated with Monte Carlo. Small inhomogeneities were observed in the dosimeter attributed to non-uniform mixing of monomer during preparation. However, they were not detrimental to this study where the quantitative accuracy and spatial resolution of polymer gel dosimetry were far superior to that calculated using scintigraphy. The difference between Monte Carlo and gel measurements was of the order of a few cGy, whilst with the scintigraphic method differences of up to 8 Gy were observed. A manipulation technique is also presented which allows 3D scintigraphic dosimetry measurements to be compared to polymer

  14. [Cancer therapy using unsealed radioisotopes-the present and future].

    PubMed

    Karasawa, Katsuyuki

    2014-12-01

    Iodine-131 (I-131) has been used for the ablation of residual thyroid remnants and cancer cells in well-differentiated thyroid cancers. It has also been used for metastatic well-differentiated thyroid cancers, especially lung and bone metastases. For small lung metastases, I-131 treatment has curative potential, particularly in young patients. Suppression of the thyroid stimulating hormone is also important for prolonging the survival of thyroid cancer patients. Strontium-89 (Sr-89) chloride has a mechanism similar to calcium, and it has been used for the treatment of bone metastases, especially osteoblastic metastases. It has been reported to have analgesic effects in an average of 76% of cases, and it is more effective if used in the early bone metastatic phase. Ibritumomab tiuxetan (Zevalin) is an anti-CD20 mouse monoclonal antibody labeled with Yttrium-90 (Y-90). It is used for treatment-resistant low grade or follicular B-cell non-Hodgkin's lymphomas and mantle lymphomas. Recently, radium-223 (Ra-223) has been used for bone metastases from castration resistant prostate cancers, and in a phase III trial, it has been proven to prolong survival of these patients. Cancer therapy using unsealed radioisotopes has been thought to be promising because it exhibits more targeted therapy than external beam irradiation. Therefore, if many more ideal targeting agents are developed in the future, this treatment might be used more commonly. As many agents such as I-131, Sr-89, and Ra-223 are available for treating bone metastasis, the combined use of other treatments such as high precision radiotherapy, bisphosphonates, hormonal agents, and molecular targeted agents should be investigated.

  15. Trends in Imaging after Thyroid Cancer Diagnosis

    PubMed Central

    Banerjee, Mousumi; Muenz, Daniel G.; Worden, Francis P.; Haymart, Megan R.

    2015-01-01

    Background The largest growth in differentiated thyroid cancer (DTC) diagnosis is in low-risk cancers. Trends in imaging after DTC diagnosis are understudied. Hypothesizing a reduction in imaging utilization due to rising low-risk disease, we evaluated post-diagnosis imaging patterns over time and patient characteristics that are associated with likelihood of imaging. Methods Using the Surveillance Epidemiology and End Results-Medicare database, we identified patients diagnosed with localized, regional or distant DTC between 1991 and 2009. We reviewed Medicare claims for neck ultrasound, I-131 scan, or PET scan within 3 years post-diagnosis. Using regression analyses we evaluated trends of imaging utilization. Multivariable logistic regression was used to estimate the likelihood of imaging based on patient characteristics. Results 23,669 patients were included. Patients diagnosed during 2001-2009, compared to 1991-2000, were more likely to have localized disease (p<0.001) and tumors less than 1cm (p<0.001). Use of neck ultrasound and I-131 scan increased in patients with localized disease (p=<0.001 and p=0.003, respectively), regional disease (p<0.001 and p<0.001), and distant metastasis (p=0.001 and p=0.015). Patients diagnosed after 2000 were more likely to undergo neck ultrasound (OR 2.15, 95% CI 2.02-2.28) and I-131 scan (OR 1.44, 95% CI 1.35-1.54). PET scan use from 2005-2009, compared to 1996-2004, increased 32.4-fold (p=<0.001) in localized patients, 13.1-fold (p<0.001) in regional disease patients, and 33.4-fold (p<0.001) in patients with distant DTC. Conclusion Despite a rise in low-risk disease, the use of post-diagnosis imaging increased in all stages of disease. The largest growth was in use of PET scan after 2004. PMID:25565063

  16. Monte Carlo verification of polymer gel dosimetry applied to radionuclide therapy: a phantom study

    NASA Astrophysics Data System (ADS)

    Gear, J. I.; Charles-Edwards, E.; Partridge, M.; Flux, G. D.

    2011-11-01

    This study evaluates the dosimetric performance of the polymer gel dosimeter 'Methacrylic and Ascorbic acid in Gelatin, initiated by Copper' and its suitability for quality assurance and analysis of I-131-targeted radionuclide therapy dosimetry. Four batches of gel were manufactured in-house and sets of calibration vials and phantoms were created containing different concentrations of I-131-doped gel. Multiple dose measurements were made up to 700 h post preparation and compared to equivalent Monte Carlo simulations. In addition to uniformly filled phantoms the cross-dose distribution from a hot insert to a surrounding phantom was measured. In this example comparisons were made with both Monte Carlo and a clinical scintigraphic dosimetry method. Dose-response curves generated from the calibration data followed a sigmoid function. The gels appeared to be stable over many weeks of internal irradiation with a delay in gel response observed at 29 h post preparation. This was attributed to chemical inhibitors and slow reaction rates of long-chain radical species. For this reason, phantom measurements were only made after 190 h of irradiation. For uniformly filled phantoms of I-131 the accuracy of dose measurements agreed to within 10% when compared to Monte Carlo simulations. A radial cross-dose distribution measured using the gel dosimeter compared well to that calculated with Monte Carlo. Small inhomogeneities were observed in the dosimeter attributed to non-uniform mixing of monomer during preparation. However, they were not detrimental to this study where the quantitative accuracy and spatial resolution of polymer gel dosimetry were far superior to that calculated using scintigraphy. The difference between Monte Carlo and gel measurements was of the order of a few cGy, whilst with the scintigraphic method differences of up to 8 Gy were observed. A manipulation technique is also presented which allows 3D scintigraphic dosimetry measurements to be compared to polymer

  17. Albumin uptake by renal lymphatics with and without obstruction of the renal vein

    SciTech Connect

    Threefoot, S.A.; Pearson, J.E. Jr.; Georgiardis, A. )

    1989-08-02

    Experiments involving injection of radio-iodinated albumin into the left renal arteries or left ureters of dogs indicate that the renal lymphatics are capable of a major contribution in returning to the circulation albumin (or other large molecules) escaping from renal capillaries. I-131-albumin was injected into the jugular vein of controls or into the left renal artery or in retrograde manner into the left ureter of female dogs. Experimental groups included those with no obstruction, occlusion of left renal veins or left renal lymphatics, or both. Collections were made from the right femoral artery, both renal veins, thoracic duct and both ureters at frequent intervals for 2 to 4 hours. Data analysis included I-131 concentration, specific activity, rate of recovery and selected ratios. After renal arterial injection, the percentage of I131 recovered in thoracic duct lymph of dogs without renal venous obstruction was 5 to 10 times that recovered in those that received injections into the jugular vein. In dogs with renal venous obstruction, recovery from the thoracic duct was 10 to 1,000 times that in control dogs. Most of the differences occurred during the first hour, after which time as recirculation and redistribution occurred the rates of appearance in thoracic duct lymph in each group were similar. The differences in the ratios of concentration in thoracic duct lymph to concentration in femoral arterial blood were also much greater when the renal vein was obstructed than in dogs with no obstruction. The greater return of albumin through the thoracic duct in those with impeded renal venous outflow was probably related to both sequestered concentration and increased intrarenal pressure.

  18. Iodination of Fab fragments: Effect of I/Fab molar ratio

    SciTech Connect

    Kishore, R.; Eary, J.F.; Beaumier, P.L.; Hellstrom, K.E.; Hellstrom, I.; Nelp, W.B.

    1985-05-01

    Radioisotopes of iodine covalently coupled to antibodies have formed the standard against which other radiolabeled antibody tracers are compared. Since the use of monoclonal antibodies (MoAb) for the diagnosis and therapy of malignant diseases is increasing rapidly the authors wished to investigate radiolabeling variables which affect the immunointegrity of radioiodinated antibodies. The authors studied the electrophilic (chloramine-T) iodination of the Fab fragment of a murine MoAb against the high molecular weight proteoglycan antigen of human melanoma. The immunoreactivity of the iodianted Fab was assessed using a cell binding assay with formaldehyde-fixed cells of a selected cell line (number 2669). The in vitro stability of the labeled fragment was studied electrophoretically. The results indicate that the reaction time and concentrations of chloramine-T were not critical within broad limits. On the other hand immunoreactivity and deiodination over time (shelf-life) were inversely related and very sensitive to I/Fab molar ratio even at concentrations below -0.1 atom of I per Fab molecule. This has important implications for the radiotherapy of malignant tumors using I-131 labeled immunoglobulins which often have higher I/Fab molar ratios (100 mCi I-131/10 mg Fab approx. = 0.5 I atoms/Fab) versus diagnostic preparations (10 mCi I-131/5 mg Fab approx. = 0.1 I atoms/Fab). Thus the authors conclude that to maintain high immunointegrity the I/Fab molar ratio should be kept low, especially for therapeutic preparations, by using correspondingly higher amounts of Fab.

  19. Considerations in the radioiodination and chelation labeling of an antiplatelet monoclonal antibody

    SciTech Connect

    Srivastava, S.C.; Meinken, G.E.; Scudder, L.E.; Coller, B.

    1985-05-01

    Radiolabeling of antibodies in particular with iodine nuclides frequently alters their biological behavior and compromises the specificity of binding to the in vivo antigens. Sensitivity to labeling chemistry however, is quite variable for different antibodies. This study was carried out to investigate the various factors affecting the binding to platelets (P) of an anti-P monoclonal antibody, 7E3, following iodination with I-123, I-125, I-131 and chelation labeling with In-111 and Tc-99m. Parameters such as the nature and amount of oxidant, reaction times, substitution level, specific activity etc., were studied. Results showed that each factor in addition to affecting chemical labeling yields also affected the binding of labeled 7E3 to P in whole blood and their blood clearance and clot uptake. With increasing I/7E3 or DTPA/7E3 molar ratios, a progressive decrease in binding to P resulted. Chloramine T (5-10 ..mu..g/100 ..mu..g 7E3) was superior to other oxidizing agents but the reaction times had to be less than or equal to2 min (labeling yields 70 +- 10%). 7E3 appeared unaffected by specific activities of up to 40 ..mu..Ci/..mu..g (I-131 and In-111) and 300 ..mu..Ci/..mu..g (I-123). Satisfactory In-111-, I-131-, or I-123-7E3-P preparations were obtained that show considerable promise for localizing in vivo thrombi. Results of this study and prior experience with other antibodies indicate that in order to achieve maximum efficacy in imaging or therapy applications, individual antibodies may require a careful optimization of labeling procedures with different radionuclides.

  20. Imaging of neuroendocrine tumors in 300 patients following injection of I-123 mIBG or 1-131 mIBG prepared from a {open_quotes}cold kit{close_quotes}

    SciTech Connect

    Karesh, S.M.; Henkin, R.E.

    1994-05-01

    During the past 6 years, we have performed approximately 300 scans for neuroendocrine tumors in an extremely varied patient base, with 65% of patients receiving I-123 mIBG and 35%, I-131 mIBG. Imaging was performed at 24-72 hr, depending upon the isotope used. The most common clinical indication was for pheochromocytoma (>90%), followed by neuroblastoma, paraganglioma, medullary carcinoma of the thyroid, and carcinoid tumors. Radiolabeling was performed by a modification of Mock`s procedure. The radioiodide was added to a very stable {open_quotes}cold kit{close_quotes} developed in-house. The kit contains 1 ml of water for injection, 2 mg of mIBG hemisulfate, and 12 mg of ammonium sulfate. After 2 heating cycles, a yield >85% and a radiochemical purity {>=}96% were routinely obtained. Overall preparation time, including determination of radiochemical purity, is approximately 2.5 hr. The only equipment required is a thermostatically controlled block heater. Biodistribution of our I-131 product was indistinguishable from that distributed by the Nuclear Pharmacy at the University of Michigan, as was the radiochemical purity; the diagnostic efficacy matched that reported in the literature. The image quality obtained using I-123 mIBG was definitely superior, due to both the much higher count rate and the ideal imaging energy of I-123. On one occasion, the I-131 scan was equivocal, whereas the I-123 scan in the same patient was clearly positive. Retrospectively, for studies performed with I-123 mIBG using the {open_quotes}cold kit{close_quotes} method, the specificity and sensitivity both exceed 90%, correlating well with multiple studies reported in the literature. The preparation of I-123 mIBG in-house using this technique is recommended.

  1. Tracking the Fukushima releases: from environmental monitoring to a showcase of CTBT verification

    NASA Astrophysics Data System (ADS)

    Steinhauser, Georg

    2013-04-01

    In the course of the Fukushima nuclear accident large amounts of antropogenic radionuclides relevant to the Comprehensive Nuclear-Test-Ban-Treaty (CTBT) were released and detected globally. Our group participated in the large European monitoring campaign and tracked fission products in various environmental media in Austria. We could show that the intake of environmental I-131 into the thyroids of wild animals can be used for verification of the CTBT. Due to continuous and highly specific accumulation of I-131, its apparent half-life in the thyroid biomonitor exceeds the physical one, thus making I-131 detectable three weeks longer than using conventional CTBT-grade high volume air samplers. This means an increase in sensitivity of almost one order of magnitude compared with conventional systems. In a second campaign we analysed the large data set of analyses of Japanese foods. Food was regarded as a geographically well localized environmental sample. The objective of this study was to determine the radiocesium activity ratio (Cs-134/137) in foods from each geographic area to possibly identify the radioactive signature of the four different reactors (i.e. four independent sources) in the distinct regions. No clear deviations from the average value (0.98) could be confirmed in the various regions. Hence, the releases from reactor No. 4 (carrying a significantly smaller activity ratio) are assumed to be small when compared with the other three reactor release. The individual radioisotopic signatures of reactors No. 1, 2, and 3 could not be identified in various Japanese regions using the food samples, indicating integral radiocesium contamination from these sources.

  2. Role of single photon emission computed tomography/computed tomography in diagnostic iodine-131 scintigraphy before initial radioiodine ablation in differentiated thyroid cancer

    PubMed Central

    Agrawal, Kanhaiyalal; Bhattacharya, Anish; Mittal, Bhagwant Rai

    2015-01-01

    Objectives: The study was performed to evaluate the incremental value of single photon emission computed tomography/computed tomography (SPECT/CT) over planar radioiodine imaging before radioiodine ablation in the staging, management and stratification of risk of recurrence (ROR) in differentiated thyroid cancer (DTC) patients. Materials and Methods: Totally, 83 patients (21 male, 62 female) aged 17–75 (mean 39.9) years with DTC were included consecutively in this prospective study. They underwent postthyroidectomy planar and SPECT/CT scans after oral administration of 37–114 MBq iodine-131 (I-131). The scans were interpreted as positive, negative or suspicious for tracer uptake in the thyroid bed, cervical lymph nodes and sites outside the neck. In each case, the findings on planar images were recorded first, without knowledge of SPECT/CT findings. Operative and pathological findings were used for postsurgical tumor–node–metastasis staging. The tumor staging was reassessed after each of these two scans. Results: Single photon emission computed tomography/computed tomography localized radioiodine uptake in the thyroid bed in 9/83 (10.8%) patients, neck nodes in 24/83 (28.9%) patients and distant metastases in 8/83 (9.6%) patients in addition to the planar study. Staging was changed in 8/83 (9.6%), ROR in 11/83 (13.2%) and management in 26/83 (31.3%) patients by the pretherapy SPECT/CT in comparison to planar imaging. SPECT/CT had incremental value in 32/83 patients (38.5%) over the planar scan. Conclusion: Single photon emission computed tomography/computed tomography is feasible during a diagnostic I-131 scan with a low amount of radiotracer. It improved the interpretation of pretherapy I-131 scintigraphy and changed the staging and subsequent patient management. PMID:26170564

  3. Iodine-131 dose dependent gene expression in thyroid cancers and corresponding normal tissues following the Chernobyl accident.

    PubMed

    Abend, Michael; Pfeiffer, Ruth M; Ruf, Christian; Hatch, Maureen; Bogdanova, Tetiana I; Tronko, Mykola D; Riecke, Armin; Hartmann, Julia; Meineke, Viktor; Boukheris, Houda; Sigurdson, Alice J; Mabuchi, Kiyohiko; Brenner, Alina V

    2012-01-01

    The strong and consistent relationship between irradiation at a young age and subsequent thyroid cancer provides an excellent model for studying radiation carcinogenesis in humans. We thus evaluated differential gene expression in thyroid tissue in relation to iodine-131 (I-131) doses received from the Chernobyl accident. Sixty three of 104 papillary thyroid cancers diagnosed between 1998 and 2008 in the Ukrainian-American cohort with individual I-131 thyroid dose estimates had paired RNA specimens from fresh frozen tumor (T) and normal (N) tissue provided by the Chernobyl Tissue Bank and satisfied quality control criteria. We first hybridized 32 randomly allocated RNA specimen pairs (T/N) on 64 whole genome microarrays (Agilent, 4×44 K). Associations of differential gene expression (log(2)(T/N)) with dose were assessed using Kruskall-Wallis and trend tests in linear mixed regression models. While none of the genes withstood correction for the false discovery rate, we selected 75 genes with a priori evidence or P kruskall/P trend <0.0005 for validation by qRT-PCR on the remaining 31 RNA specimen pairs (T/N). The qRT-PCR data were analyzed using linear mixed regression models that included radiation dose as a categorical or ordinal variable. Eleven of 75 qRT-PCR assayed genes (ACVR2A, AJAP1, CA12, CDK12, FAM38A, GALNT7, LMO3, MTA1, SLC19A1, SLC43A3, ZNF493) were confirmed to have a statistically significant differential dose-expression relationship. Our study is among the first to provide direct human data on long term differential gene expression in relation to individual I-131 doses and to identify a set of genes potentially important in radiation carcinogenesis.

  4. Recommendations to Minimize Timely Payment Problems of Subcontractors Involved in Private and Public Building Construction in Pennsylvania.

    DTIC Science & Technology

    1982-05-01

    mndatre’ Is I o on any amounts recovered in litigation will be covered under the bond. In New York, a recent ammendment to their law was passed with...Payments Made by Agencies of the Federal Government, Providing for the Elimination of Retainage in Certain Instances. S. 1782, 97th Congress, 1st Session...1981. 22. U.S. Congress. Senate. A Bill to Require the Federal Government to Pay Interest on Overdue Payments. S. i131, 97th Cong., 1st Sess., 1981. 23

  5. Patient-specific dosimetry based on quantitative SPECT imaging and 3D-DFT convolution

    SciTech Connect

    Akabani, G.; Hawkins, W.G.; Eckblade, M.B.; Leichner, P.K.

    1999-01-01

    The objective of this study was to validate the use of a 3-D discrete Fourier Transform (3D-DFT) convolution method to carry out the dosimetry for I-131 for soft tissues in radioimmunotherapy procedures. To validate this convolution method, mathematical and physical phantoms were used as a basis of comparison with Monte Carlo transport (MCT) calculations which were carried out using the EGS4 system code. The mathematical phantom consisted of a sphere containing uniform and nonuniform activity distributions. The physical phantom consisted of a cylinder containing uniform and nonuniform activity distributions. Quantitative SPECT reconstruction was carried out using the Circular Harmonic Transform (CHT) algorithm.

  6. Radionuclide therapy of adrenal tumors.

    PubMed

    Carrasquillo, Jorge A; Pandit-Taskar, Neeta; Chen, Clara C

    2012-10-01

    Adrenal tumors arising from chromaffin cells will often accumulate radiolabeled metaiodobenzylguanidine (MIBG) and thus are amenable to therapy with I-131 MIBG. More recently, therapy studies have targeted the somatostatin receptors using Lu-177 or Y-90 radiolabeled somatostatin analogs. Because pheochromocytoma (PHEO)/paraganglioma (PGL) and neuroblastoma (NB), which often arise from the adrenals, express these receptors, clinical trials have been performed with these reagents. We will review the experience using radionuclide therapy for targeting PHEO/PGL and NBs. Copyright © 2012 Wiley Periodicals, Inc.

  7. (131)I-Nimotuzumab - A potential radioimmunotherapeutic agent in treatment of tumors expressing EGFR.

    PubMed

    Kameswaran, Mythili; Samuel, Grace; Dev Sarma, Haladhar; Shinde, Swamirao N; Dash, Ashutosh; Venkatesh, Meera

    2015-08-01

    The anti-EGFR antibody Nimotuzumab was radioiodinated with I-131 by Chloramine T and Iodogen methods. The (131)I-Nimotuzumab was purified and characterized by HPLC. Purified (131)I-Nimotuzumab exhibited radiochemical purity of >95% and retained good in vitro stability upto 24h at room temperature by both the methods. Cell binding studies carried out in A431 cells expressing EGF receptors showed good immunoreactivity of the product upto 5 days post radioiodination. Biodistribution studies in normal Swiss mice showed fast clearance by both renal and gastrointestinal routes with minimal thyroid uptake. Copyright © 2015 Elsevier Ltd. All rights reserved.

  8. Analytics of Radioactive Materials Released in the Fukushima Daiichi Nuclear Accident

    SciTech Connect

    Egarievwe, Stephen U.; Coble, Jamie B.; Miller, Laurence F.

    2015-07-01

    The 2011 Fukushima Daiichi nuclear accident in Japan resulted in the release of radioactive materials into the atmosphere, the nearby sea, and the surrounding land. Following the accident, several meteorological models were used to predict the transport of the radioactive materials to other continents such as North America and Europe. Also of high importance is the dispersion of radioactive materials locally and within Japan. Based on the International Atomic Energy Agency (IAEA) Convention on Early Notification of a nuclear accident, several radiological data sets were collected on the accident by the Japanese authorities. Among the radioactive materials monitored, are I-131 and Cs-137 which form the major contributions to the contamination of drinking water. The radiation dose in the atmosphere was also measured. It is impractical to measure contamination and radiation dose in every place of interest. Therefore, modeling helps to predict contamination and radiation dose. Some modeling studies that have been reported in the literature include the simulation of transport and deposition of I-131 and Cs-137 from the accident, Cs-137 deposition and contamination of Japanese soils, and preliminary estimates of I-131 and Cs-137 discharged from the plant into the atmosphere. In this paper, we present statistical analytics of I-131 and Cs-137 with the goal of predicting gamma dose from the Fukushima Daiichi nuclear accident. The data sets used in our study were collected from the IAEA Fukushima Monitoring Database. As part of this study, we investigated several regression models to find the best algorithm for modeling the gamma dose. The modeling techniques used in our study include linear regression, principal component regression (PCR), partial least square (PLS) regression, and ridge regression. Our preliminary results on the first set of data showed that the linear regression model with one variable was the best with a root mean square error of 0.0133 μSv/h, compared

  9. 10 CFR 30.70 - Schedule A-Exempt concentrations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... concentration µCi/ml 1 Col. II Liquid and solid concentration µCi/ml 2 Antimony (51) Sb 122 3×10−4 Sb 124 2×10−4...×10−2 In 114m 2×10−4 Iodine (53) I 126 3×10−9 2×10−5 I 131 3×10−9 2×10−5 I 132 8×10−8 6×10−4 I 133...

  10. 10 CFR 30.70 - Schedule A-Exempt concentrations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... concentration µCi/ml 1 Col. II Liquid and solid concentration µCi/ml 2 Antimony (51) Sb 122 3×10−4 Sb 124 2×10−4...×10−2 In 114m 2×10−4 Iodine (53) I 126 3×10−9 2×10−5 I 131 3×10−9 2×10−5 I 132 8×10−8 6×10−4 I 133...

  11. 10 CFR 30.70 - Schedule A-Exempt concentrations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... concentration µCi/ml 1 Col. II Liquid and solid concentration µCi/ml 2 Antimony (51) Sb 122 3×10−4 Sb 124 2×10−4...×10−2 In 114m 2×10−4 Iodine (53) I 126 3×10−9 2×10−5 I 131 3×10−9 2×10−5 I 132 8×10−8 6×10−4 I 133...

  12. 10 CFR 30.70 - Schedule A-Exempt concentrations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... concentration µCi/ml 1 Col. II Liquid and solid concentration µCi/ml 2 Antimony (51) Sb 122 3×10−4 Sb 124 2×10−4...×10−2 In 114m 2×10−4 Iodine (53) I 126 3×10−9 2×10−5 I 131 3×10−9 2×10−5 I 132 8×10−8 6×10−4 I 133...

  13. 10 CFR 30.70 - Schedule A-Exempt concentrations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... concentration µCi/ml 1 Col. II Liquid and solid concentration µCi/ml 2 Antimony (51) Sb 122 3×10−4 Sb 124 2×10−4...×10−2 In 114m 2×10−4 Iodine (53) I 126 3×10−9 2×10−5 I 131 3×10−9 2×10−5 I 132 8×10−8 6×10−4 I 133...

  14. Practical solid and liquid phase markers for studying gastric emptying in man

    SciTech Connect

    Thomforde, G.M.; Brown, M.L.; Malagelada, J.R.

    1985-03-01

    This paper presents a method used to evaluate solid and liquid phase markers for radionuclide gastric emptying studies. The authors conducted in vitro and in vivo comparative experiments employing several radiolabeled markers. Among the solid phase markers tested, Tc-99m-sulfur colloid in vivo-labeled liver and I-131-fiber performed optimally. However, Tc-99M sulfur colloid in scrambled egg showed very acceptable performance and it is significantly easier to prepare. Among liquid phase markers, they found In-111-DTPA stabilized with 1% albumin to be a good agent and appropriate for dual isotope emptying studies.

  15. Sublingual pyramidal lobe. Complications of subtotal thyroidectomy for Graves' disease

    SciTech Connect

    Sternberg, J.L.

    1986-11-01

    A potential complication of subtotal thyroidectomy where a large pyramidal lobe is present is described. The pyramidal lobe normally is immobilized inferiorly by its attachment to the thyroidal isthmus. When the isthmus is removed and the pyramidal lobe is left in situ during subtotal thyroidectomy its superior attachments will allow the pyramidal lobe to become situated sublingually. This may produce gagging and nausea. To avoid the complication, it is recommended that the pyramidal lobe be removed during subtotal thyroidectomy. If the patient also is thyrotoxic, I-131 can be used to treat this complication successfully.

  16. Somatostatin receptor positron emission tomography/computed tomography (PET/CT) in the evaluation of opsoclonus-myoclonus ataxia syndrome

    PubMed Central

    Joshi, Prathamesh; Lele, Vikram

    2013-01-01

    Opsoclonus-myoclonus ataxia (OMA) syndrome is the most common paraneoplastic neurological syndrome of childhood, associated with occult neuroblastoma in 20%-50% of all cases. OMA is the initial presentation of neuroblastoma in 1%-3% of children. Conventional radiological imaging approaches include chest radiography and abdominal computed tomography (CT). Nuclear medicine techniques, in form of 123I/131I-metaiodobenzylguanidine (MIBG) scintigraphy have been incorporated in various diagnostic algorithms for evaluation of OMA. We describe use of somatostatin receptor PET/CT with 68Gallium- DOTA-DPhe1, Tyr3-octreotate (DOTATATE) in diagnosis of neuroblastoma in two cases of OMA. PMID:24163518

  17. Nondestructive measurement of environmental radioactive strontium

    NASA Astrophysics Data System (ADS)

    Saiba, Shuntaro; Okamiya, Tomohiro; Tanaka, Saki; Tanuma, Ryosuke; Totsuka, Yumi; Murata, Jiro

    2014-03-01

    The Fukushima Daiichi nuclear power plant accident was triggered by the 2011 Great East Japan Earthquake. The main radioactivity concerns after the accident are I-131 (half-life: 8.0 days), Cs-134 (2.1 years), Cs-137 (30 years), Sr-89 (51 days), and Sr-90 (29 years). We are aiming to establish a new nondestructive measurement and detection technique that will enable us to realize a quantitative evaluation of strontium radioactivity without chemical separation processing. This technique is needed to detect radiation contained in foods, environmental water, and soil, to prevent us from undesired internal exposure to radiation.

  18. Human radiation studies: Remembering the early years. Oral history of Dr. Nadine Foreman, M.D., August 19, 1994

    SciTech Connect

    1995-07-01

    Dr. Nadine Foreman was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). Dr. Foreman was selected for interview because of the position she held at the University of California, San Francisco. Following a brief biographical sketch, Dr. Foreman describes her work with Dr. Mayo Soley using I-131 in treatment of hyperthyroidism, selection criteria for patients in the radioiodine project, work with Dr. Earl Miller, work at Highland Hospital, radioiodine treatment of diffuse toxic goiter (myxedema), the radiophosphorus and radioiodine programs with Dr. Bert Low-Beer, and treatment of polycythemia vera.

  19. Radiochemical analysis of the first plateout probe from the Fort St. Vrain high-temperature gas-cooled reactor

    SciTech Connect

    Burnette, R.D.

    1982-06-01

    This report presents the analysis of radioactive elements on the first plateout probe from the Fort St. Vrain high-temperature gas-cooled reactor. The plateout probe is a device which samples the primary coolant for condensible fission products. Circuit inventories of individual radionuclides are estimated from the probe analysis. The analysis shows that the radioactive contamination in the primary circuit is remarkable low, with activation product concentrations much greater than that of fission products. The analysis demonstrates that the concentrations of the key fission products I-131 and Sr-90 are far below the limits allowed by the technical specification.

  20. Improved radioimmunotherapy of hematologic malignancies. Final technical report

    SciTech Connect

    Press, O.W.

    1996-08-15

    Experiments were performed to study the rates of endocytosis, intracellular routing, and metabolic degradation of radiolabeled monoclonal antibodies targeting tumor-associated antigens on human leukemia and lymphoma cells. An attempt was made to examine in vivo the effects of lysosomotropic amines and thioamides on the retention of radiolabeled monoclonal antibodies by tumor cells. Experiments also examined the impact of newer radioiodination techniques on the metabolic degradation of radioiodinated antibodies, and on the radioimmunoscintigraphy and radioimmunotherapy of neoplasms. The endocytosis, intracellular routing, and degradation of radioimmunoconjugates prepared with I-131, In-111, and Y-90 were compared. The utility of radioimmunoconjugates targeting oncogene products for the radioimmunotherapy and radioimmunoscintigraphy of cancer was investigated.