Sample records for ibc design types

  1. A relativistic type Ibc supernova without a detected gamma-ray burst.

    PubMed

    Soderberg, A M; Chakraborti, S; Pignata, G; Chevalier, R A; Chandra, P; Ray, A; Wieringa, M H; Copete, A; Chaplin, V; Connaughton, V; Barthelmy, S D; Bietenholz, M F; Chugai, N; Stritzinger, M D; Hamuy, M; Fransson, C; Fox, O; Levesque, E M; Grindlay, J E; Challis, P; Foley, R J; Kirshner, R P; Milne, P A; Torres, M A P

    2010-01-28

    Long duration gamma-ray bursts (GRBs) mark the explosive death of some massive stars and are a rare sub-class of type Ibc supernovae. They are distinguished by the production of an energetic and collimated relativistic outflow powered by a central engine (an accreting black hole or neutron star). Observationally, this outflow is manifested in the pulse of gamma-rays and a long-lived radio afterglow. Until now, central-engine-driven supernovae have been discovered exclusively through their gamma-ray emission, yet it is expected that a larger population goes undetected because of limited satellite sensitivity or beaming of the collimated emission away from our line of sight. In this framework, the recovery of undetected GRBs may be possible through radio searches for type Ibc supernovae with relativistic outflows. Here we report the discovery of luminous radio emission from the seemingly ordinary type Ibc SN 2009bb, which requires a substantial relativistic outflow powered by a central engine. A comparison with our radio survey of type Ibc supernovae reveals that the fraction harbouring central engines is low, about one per cent, measured independently from, but consistent with, the inferred rate of nearby GRBs. Independently, a second mildly relativistic supernova has been reported.

  2. 49 CFR 173.35 - Hazardous materials in IBCs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., cracks, cuts, or other damage which would render it unable to pass the prescribed design type test to... metal, rigid plastic, or composite IBC that is appropriately resistant to an increase in internal pressure likely to develop during transportation. (1) A rigid plastic or composite IBC may only be filled...

  3. 49 CFR 173.35 - Hazardous materials in IBCs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., cracks, cuts, or other damage which would render it unable to pass the prescribed design type test to... plastic or composite IBC may only be filled with a liquid having a vapor pressure less than or equal to... -57 portable tanks. (j) No IBC may be filled with a Packing Group I liquid. Rigid plastic, composite...

  4. 49 CFR 178.706 - Standards for rigid plastic IBCs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Standards for rigid plastic IBCs. 178.706 Section... Performance-Oriented Standards § 178.706 Standards for rigid plastic IBCs. (a) The provisions in this section apply to rigid plastic IBCs intended to contain solids or liquids. Rigid plastic IBC types are...

  5. 49 CFR 178.706 - Standards for rigid plastic IBCs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Standards for rigid plastic IBCs. 178.706 Section... Performance-Oriented Standards § 178.706 Standards for rigid plastic IBCs. (a) The provisions in this section apply to rigid plastic IBCs intended to contain solids or liquids. Rigid plastic IBC types are...

  6. 49 CFR 178.706 - Standards for rigid plastic IBCs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Standards for rigid plastic IBCs. 178.706 Section... Performance-Oriented Standards § 178.706 Standards for rigid plastic IBCs. (a) The provisions in this section apply to rigid plastic IBCs intended to contain solids or liquids. Rigid plastic IBC types are...

  7. 49 CFR 178.706 - Standards for rigid plastic IBCs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Standards for rigid plastic IBCs. 178.706 Section... Performance-Oriented Standards § 178.706 Standards for rigid plastic IBCs. (a) The provisions in this section apply to rigid plastic IBCs intended to contain solids or liquids. Rigid plastic IBC types are...

  8. 49 CFR 178.710 - Standards for flexible IBCs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... used in the manufacture of the tested design type, retesting may be omitted if the carbon black content... material. (6) No used material other than production residues or regrind from the same manufacturing process may be used in the manufacture of plastic flexible IBCs. This does not preclude the re-use of...

  9. A comparison of IBC with 1997 UBC for modal response spectrum analysis in standard-occupancy buildings

    NASA Astrophysics Data System (ADS)

    Nahhas, Tariq M.

    2011-03-01

    This paper presents a comparison of the seismic forces generated from a Modal Response Spectrum Analysis (MRSA) by applying the provisions of two building codes, the 1997 Uniform Building Code (UBC) and the 2000-2009 International Building Code (IBC), to the most common ordinary residential buildings of standard occupancy. Considering IBC as the state of the art benchmark code, the primary concern is the safety of buildings designed using the UBC as compared to those designed using the IBC. A sample of four buildings with different layouts and heights was used for this comparison. Each of these buildings was assumed to be located at four different geographical sample locations arbitrarily selected to represent various earthquake zones on a seismic map of the USA, and was subjected to code-compliant response spectrum analyses for all sample locations and for five different soil types at each location. Response spectrum analysis was performed using the ETABS software package. For all the cases investigated, the UBC was found to be significantly more conservative than the IBC. The UBC design response spectra have higher spectral accelerations, and as a result, the response spectrum analysis provided a much higher base shear and moment in the structural members as compared to the IBC. The conclusion is that ordinary office and residential buildings designed using UBC 1997 are considered to be overdesigned, and therefore they are quite safe even according to the IBC provisions.

  10. Multilayer limb quasi-static electromagnetic modeling with experiments for Galvanic coupling type IBC.

    PubMed

    Pun, S H; Gao, Y M; Mou, P A; Mak, P U; Vai, M I; Du, M

    2010-01-01

    Intra-body communication (IBC) is a new, emerging, short-range and human body based communication methodology. It is a technique to network various devices on human body, by utilizing the conducting properties of human tissues. For currently fast developed Body area network(BAN)/Body sensor network(BSN), IBC is believed to have advantages in power consumption, electromagnetic radiation, interference from external electromagnetic noise, security, and restriction in spectrum resource. In this article, the authors propose an improved mathematical model, which includes both electrical properties and proportion of human tissues, for IBC on a human limb. By solving the mathematical model analytically on four-layer system (skin, fat, muscle, and bone) and conducting in-vivo experiment, a comparison has been conducted.

  11. 49 CFR 178.710 - Standards for flexible IBCs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) Definitions for flexible IBCs: (1) Flexible IBCs consist of a body constructed of film, woven plastic, woven... body of the IBC or formed from a continuation of the IBC body material. (c) Construction requirements... in previous use. (7) When flexible IBCs are filled, the ratio of height to width may not be more than...

  12. 49 CFR 178.710 - Standards for flexible IBCs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) Definitions for flexible IBCs: (1) Flexible IBCs consist of a body constructed of film, woven plastic, woven... body of the IBC or formed from a continuation of the IBC body material. (c) Construction requirements... in previous use. (7) When flexible IBCs are filled, the ratio of height to width may not be more than...

  13. 49 CFR 178.710 - Standards for flexible IBCs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) Definitions for flexible IBCs: (1) Flexible IBCs consist of a body constructed of film, woven plastic, woven... body of the IBC or formed from a continuation of the IBC body material. (c) Construction requirements... in previous use. (7) When flexible IBCs are filled, the ratio of height to width may not be more than...

  14. 49 CFR 178.710 - Standards for flexible IBCs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) Definitions for flexible IBCs: (1) Flexible IBCs consist of a body constructed of film, woven plastic, woven... body of the IBC or formed from a continuation of the IBC body material. (c) Construction requirements... in previous use. (7) When flexible IBCs are filled, the ratio of height to width may not be more than...

  15. 49 CFR 178.707 - Standards for composite IBCs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Standards for composite IBCs. 178.707 Section 178... PACKAGINGS IBC Performance-Oriented Standards § 178.707 Standards for composite IBCs. (a) The provisions in this section apply to composite IBCs intended to contain solids and liquids. To complete the marking...

  16. 49 CFR 178.707 - Standards for composite IBCs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... designed to bear the entire stacking load. The inner receptacle and outer packaging form an integral... outer packaging. (2) A composite IBC with a fully enclosing outer packaging must be designed to permit assessment of the integrity of the inner container following the leakproofness and hydraulic tests. The outer...

  17. 49 CFR 178.802 - Preparation of fiberboard IBCs for testing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SPECIFICATIONS... IBCs and composite IBCs with fiberboard outer packagings must be conditioned for at least 24 hours in..., fiberboard IBCs or composite IBCs with fiberboard outer packagings may be at ambient conditions. [Amdt. 178...

  18. 49 CFR 180.352 - Requirements for retest and inspection of IBCs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... inspections for metal, rigid plastic, and composite IBCs. Each IBC is subject to the following test and... proper examination of the IBC body. (3) Each metal, rigid plastic and composite IBC must be internally... from cuts, tears and punctures. Additionally, fabric must be free from scoring which may render the IBC...

  19. 49 CFR 180.352 - Requirements for retest and inspection of IBCs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... inspections for metal, rigid plastic, and composite IBCs. Each IBC is subject to the following test and... proper examination of the IBC body. (3) Each metal, rigid plastic and composite IBC must be internally... from cuts, tears and punctures. Additionally, fabric must be free from scoring which may render the IBC...

  20. 49 CFR 180.352 - Requirements for retest and inspection of IBCs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... inspections for metal, rigid plastic, and composite IBCs. Each IBC is subject to the following test and... proper examination of the IBC body. (3) Each metal, rigid plastic and composite IBC must be internally... from cuts, tears and punctures. Additionally, fabric must be free from scoring which may render the IBC...

  1. 49 CFR 180.352 - Requirements for retest and inspection of IBCs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... inspections for metal, rigid plastic, and composite IBCs. Each IBC is subject to the following test and... proper examination of the IBC body. (3) Each metal, rigid plastic and composite IBC must be internally... from cuts, tears and punctures. Additionally, fabric must be free from scoring which may render the IBC...

  2. 49 CFR 178.703 - Marking of IBCs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...). For metal IBCs on which the marking is stamped or embossed, the capital letters “UN” may be applied... the allocation of the mark. The letters ‘USA’ indicate that the IBC is manufactured and marked in the...

  3. 49 CFR 178.704 - General IBC standards.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... materials must be sift-proof and water-resistant. (b) All service equipment must be so positioned or... withstand, without loss of hazardous materials, the internal pressure of the contents and the stresses of... stress in any part of the IBC. (d) An IBC consisting of a packaging within a framework must be so...

  4. 49 CFR 173.35 - Hazardous materials in IBCs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... part 180 of this subchapter is past due, may not be filled and offered for transportation until the... this subchapter.) An IBC other than a multiwall paper IBC (13M1 and 13M2) may be reused. If an inner...

  5. The Double-peaked SN 2013ge: A Type Ib/c SN with an Asymmetric Mass Ejection or an Extended Progenitor Envelope

    NASA Astrophysics Data System (ADS)

    Drout, M. R.; Milisavljevic, D.; Parrent, J.; Margutti, R.; Kamble, A.; Soderberg, A. M.; Challis, P.; Chornock, R.; Fong, W.; Frank, S.; Gehrels, N.; Graham, M. L.; Hsiao, E.; Itagaki, K.; Kasliwal, M.; Kirshner, R. P.; Macomb, D.; Marion, G. H.; Norris, J.; Phillips, M. M.

    2016-04-01

    We present extensive multiwavelength (radio to X-ray) observations of the Type Ib/c supernova (SN Ib/c) SN 2013ge from -13 to +457 days relative to maximum light, including a series of optical spectra and Swift UV-optical photometry beginning 2-4 days post-explosion. This data set makes SN 2013ge one of the best-observed normal SNe Ib/c at early times—when the light curve is particularly sensitive to the progenitor configuration and mixing of radioactive elements—and reveals two distinct light curve components in the UV bands. The first component rises over 4-5 days and is visible for the first week post-explosion. Spectra of the first component have blue continua and show a plethora of moderately high velocity (˜15,000 km s-1) but narrow (˜3500 km s-1) spectroscopic features, indicating that the line-forming region is restricted. The explosion parameters estimated for the bulk explosion ({M}{{ej}} ˜ 2-3 {M}⊙ ; {E}{{K}} ˜ (1-2) × 1051 erg) are standard for SNe Ib/c, and there is evidence for weak He features at early times—in an object that would have otherwise been classified as Type Ic. In addition, SN 2013ge exploded in a low-metallicity environment (˜0.5 {Z}⊙ ), and we have obtained some of the deepest radio and X-ray limits for an SN Ib/c to date, which constrain the progenitor mass-loss rate to be \\dot{M} < 4 × 10-6 {M}⊙ yr-1. We are left with two distinct progenitor scenarios for SN 2013ge, depending on our interpretation of the early emission. If the first component is cooling envelope emission, then the progenitor of SN 2013ge either possessed an extended (≳30 {R}⊙ ) envelope or ejected a portion of its envelope in the final ≲ 1 yr before core collapse. Alternatively, if the first component is due to outwardly mixed 56Ni, then our observations are consistent with the asymmetric ejection of a distinct clump of nickel-rich material at high velocities. Current models for the collision of an SN shock with a binary companion cannot

  6. A cluster of inflammatory breast cancer (IBC) in an office setting: additional evidence of the importance of environmental factors in IBC etiology.

    PubMed

    Duke, Tina J; Jahed, Nasreen C; Veneroso, Carmela C; Da Roza, Ricardo; Johnson, Owen; Hoffman, Daniel; Barsky, Sanford H; Levine, Paul H

    2010-11-01

    We investigated a cluster of three cases of inflammatory breast cancer (IBC) diagnosed within 10 months in an office setting of 24 people. Information about medical history, pregnancy history, family history of breast cancer, oral contraceptive use/hormone replacement therapy, exposure to possible oncogenic agents and tumor promoters were obtained to determine whether there were differences in risk factors for IBC between cases and controls. The physical environment and location of the cases' office raised concern about air and water quality as well as radiation as being contributory risk factors for developing IBC. Of the three women with IBC, two had high exposures to pesticides/herbicides, all three used oral contraceptives and two used hormone replacement therapy at the time of diagnosis, two had a family history of breast cancer, and two were obese. Among fifteen controls four had pesticide/herbicide exposure, one had a family history of breast cancer, nine used oral contraceptives, seven used hormone replacement therapy, and five were obese. No specific environmental causes were established for this cluster. Several promoting factors have been suggested that could result in subclinical breast cancer emerging as IBC. Among them are exogenous hormones and exposure to herbicides/pesticides.

  7. 49 CFR 178.709 - Standards for wooden IBCs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... IBC. (i) Natural wood used in the construction of an IBC must be well-seasoned, commercially dry, and... be used for the construction of structural equipment of the outer packaging. (iii) Reconstituted wood used in construction of bodies must be water resistant reconstituted wood such as hardboard or particle...

  8. 49 CFR 173.35 - Hazardous materials in IBCs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... plastic or composite IBC may only be filled with a liquid having a vapor pressure less than or equal to... -57 portable tanks. (j) No IBC may be filled with a Packing Group I liquid. Rigid plastic, composite... point of 60 °C (140 °F) (closed cup) or lower, or powders with the potential for dust explosion...

  9. A Carcinogenicity Bioassay of Isobutyl 2-Cyanoacrylate (IBC) in Fischer-344 Rats

    DTIC Science & Technology

    1990-01-23

    subcutaneous mass M Control 084 24 Oct 85 Pallor, weak, depressed M Low IBC 080 24 Oct 85 Died in cage M High IBC 203 24 Oct 85 Pallor, large M Low IBC intra...abdominal mass 424 25 Oct 85 Weight loss, dehydrated, F High IBC depressed * Animals were sacrificed to conserve tissues in face of imminent death...bioassays due to its low incidence of spontaneous mammary gland and liver cancer . This strain is recommended by the NCI Carcinogenesis Bioassay Program

  10. The Double-Peaked SN 2013ge: A Type Ib/c Sn with an Asymmetric Mass Ejection or an Extended Progenitor Envelope

    NASA Technical Reports Server (NTRS)

    Drout, M. R.; Milisavjlevic, D.; Parrent, J.; Margutti, R.; Kamble, A.; Soderberg, A.M.; Challis, P.; Chornock, P.; Fong, W.; Frank, S.; hide

    2016-01-01

    We present extensive multiwavelength (radio to X-ray) observations of the Type Ib/c supernova (SN Ib c) SN 2013ge from -13 to +457 days relative to maximum light, including a series of optical spectra and Swift UV-optical photometry beginning 2-4 days post-explosion. This data set makes SN 2013ge one of the best-observed normal SNe Ib/c at early times-when the light curve is particularly sensitive to the progenitor configuration and mixing of radioactive elements -and reveals two distinct light curve components in the UV bands. The first component rises over 4-5 days and is visible for the first week post-explosion. Spectra of the first component have blue continua and show a plethora of moderately high velocity (approximately 15,000 km/s) but narrow (approximately 3500 km/s)spectroscopic features, indicating that the line-forming region is restricted. The explosion parameters estimated for the bulk explosion (M(sub ej) approximately 23 solar mass; E(subK) approximately (1-2) x 10(exp 51) erg) are standard for SNe Ib/c, and there is evidence forweak He features at early times-in an object that would have otherwise been classified as Type Ic. In addition,SN 2013ge exploded in a low-metallicity environment (approximately 0.5 atomic mass), and we have obtained some of the deepest radio and X-ray limits for an SN Ib/c to date, which constrain the progenitor mass-loss rate to be M less than 4 x 10(exp -6) solar mass/yr. We are left with two distinct progenitor scenarios for SN 2013ge, depending on our interpretation of the early emission. If the first component is cooling envelope emission, then the progenitor of SN 2013ge either possessed an extended (greater than or approximately 30 solar radius) envelope or ejected a portion of its envelope in the final less than or approximately 1 yr before core collapse. Alternatively, if the first component is due to outwardly mixed Ni-56, then our observations are consistent with the asymmetric ejection of a distinct clump of

  11. 49 CFR 180.352 - Requirements for retest and inspection of IBCs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... qualification tests. The IBC must be externally inspected for cracks, warpage, corrosion or any other damage... IBC must be internally inspected for cracks, warpage, and corrosion or any other defect that might.... Inner protrusions which could puncture or abrade the liner must be covered. (d) Requirements applicable...

  12. 49 CFR 178.803 - Testing and certification of IBCs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Vibration 6 X 6 X 6 X 6 X 6 X 1.5 X Bottom lift 2 X X X X X Top lift 2 X 2 X 2 X 2 5 X Stacking 7 X 7 X 7 X... X Righting 2 5 X Tear 5 X 1 Flexible IBCs must be capable of withstanding the vibration test. 2 This... each test. 6 The vibration test may be performed in another order for IBCs manufactured and tested...

  13. 49 CFR 178.803 - Testing and certification of IBCs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Vibration 6 X 6 X 6 X 6 X 6 X 1.5 X Bottom lift 2 X X X X X Top lift 2 X 2 X 2 X 2,5 X Stacking 7 X 7 X 7 X... X Righting 2,5 X Tear 5 X 1 Flexible IBCs must be capable of withstanding the vibration test. 2 This... each test. 6 The vibration test may be performed in another order for IBCs manufactured and tested...

  14. 49 CFR 178.803 - Testing and certification of IBCs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Vibration 6 X 6 X 6 X 6 X 6 X 1.5 X Bottom lift 2 X X X X X Top lift 2 X 2 X 2 X 2 5 X Stacking 7 X 7 X 7 X... X Righting 2 5 X Tear 5 X 1 Flexible IBCs must be capable of withstanding the vibration test. 2 This... each test. 6 The vibration test may be performed in another order for IBCs manufactured and tested...

  15. Ion Implantation with in-situ Patterning for IBC Solar Cells

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Graff, John W.

    2014-10-24

    Interdigitated back-side Contact (IBC) solar cells are the highest efficiency silicon solar cells currently on the market. Unfortunately the cost to produce these solar cells is also very high, due to the large number of processing steps required. Varian believes that only the combination of high efficiency and low cost can meet the stated goal of $1/Wp. The core of this program has been to develop an in-situ patterning capability for an ion implantation system capable of producing patterned doped regions for IBC solar cells. Such a patterning capable ion implanter can reduce the number of process steps required tomore » manufacture IBC cells, and therefore significantly reduce the cost. The present program was organized into three phases. Phase I was to select a patterning approach and determine the patterning requirements for IBC cells. Phase II consists of construction of a Beta ion implantation system containing in-situ patterning capability. Phase III consists of shipping and installation of the ion implant system in a customer factory where it will be tested and proven in a pilot production line.« less

  16. 49 CFR 178.703 - Marking of IBCs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... marking is stamped or embossed, the capital letters “UN” may be applied instead of the symbol. (ii) The.... The letters ‘USA’ indicate that the IBC is manufactured and marked in the United States in compliance...

  17. 49 CFR 178.703 - Marking of IBCs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... marking is stamped or embossed, the capital letters “UN” may be applied instead of the symbol. (ii) The.... The letters ‘USA’ indicate that the IBC is manufactured and marked in the United States in compliance...

  18. 49 CFR 178.703 - Marking of IBCs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... marking is stamped or embossed, the capital letters “UN” may be applied instead of the symbol. (ii) The.... The letters ‘USA’ indicate that the IBC is manufactured and marked in the United States in compliance...

  19. 49 CFR 178.703 - Marking of IBCs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... marking is stamped or embossed, the capital letters “UN” may be applied instead of the symbol. (ii) The.... The letters ‘USA’ indicate that the IBC is manufactured and marked in the United States in compliance...

  20. 49 CFR 178.704 - General IBC standards.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., deterioration due to exposure to the external environment. IBCs intended for solid hazardous materials must be... must be constructed in such a way as to be bottom-lifted or top-lifted as specified in §§ 178.811 and...

  1. 49 CFR 178.704 - General IBC standards.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., deterioration due to exposure to the external environment. IBCs intended for solid hazardous materials must be... must be constructed in such a way as to be bottom-lifted or top-lifted as specified in §§ 178.811 and...

  2. Large Format Si:As IBC Array Performance for NGST and Future IR Space Telescope Applications

    NASA Technical Reports Server (NTRS)

    Ennico, Kimberly; Johnson, Roy; Love, Peter; Lum, Nancy; McKelvey, Mark; McCreight, Craig; McMurray, Robert, Jr.; DeVincenzi, D. (Technical Monitor)

    2002-01-01

    A mid-IR (5-30micrometer) instrument aboard a cryogenic space telescope can have an enormous impact in resolving key questions in astronomy and cosmology. A space platform's greatly reduced thermal backgrounds (compared to airborne or ground-based platforms), allow for more sensitive observations of dusty young galaxies at high redshifts, star formation of solar-type stars in the local universe, and formation and evolution of planetary disks and systems. The previous generation's largest, in sensitive IR detectors at these wavelengths are 256x256 pixel Si:As Impurity Band Conduction (IBC) devices built by Raytheon Infrared Operations (RIO) for the Space Infrared Telescope Facility/Infrared Array Camera (SIRTF)/(IRAC) instrument. RIO has successfully enhanced these devices, increasing the pixel count by a factor of 16 while matching or exceeding SIRTF/IRAC device performance. NASA-ARC in collaboration with RIO has tested the first high performance large format (1024x 1024) Si:As IBC arrays for low background applications, such as for the middle instrument on Next Generation Space Telescope (NGST) and future IR Explorer missions. These hybrid devices consist of radiation hard SIRTF/IRAC-type Si:As IBC material mated to a readout multiplexer that has been specially processed for operation at low cryogenic temperatures (below 10K), yielding high device sensitivity over a wavelength range of 5-28 micrometers. We present laboratory testing results from these benchmark, devices. Continued development in this technology is essential for conducting large-area surveys of the local and early universe through observation and for complementing future missions such as NGST, Terrestrial Planet Finder (TPF), and Focal Plane Instruments and Requirement Science Team (FIRST).

  3. 49 CFR 178.705 - Standards for metal IBCs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... metal lattice-work casing. (c) Construction requirements for metal IBCs are as follows: (1) Body. The... minimum elongation (as a percentage) of the reference steel to be used on fracture under tensile stress...

  4. 49 CFR 178.705 - Standards for metal IBCs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... metal lattice-work casing. (c) Construction requirements for metal IBCs are as follows: (1) Body. The... minimum elongation (as a percentage) of the reference steel to be used on fracture under tensile stress...

  5. 49 CFR 178.705 - Standards for metal IBCs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY...-work casing. (c) Construction requirements for metal IBCs are as follows: (1) Body. The body must be... minimum elongation (as a percentage) of the reference steel to be used on fracture under tensile stress...

  6. 49 CFR 178.705 - Standards for metal IBCs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY...-work casing. (c) Construction requirements for metal IBCs are as follows: (1) Body. The body must be... minimum elongation (as a percentage) of the reference steel to be used on fracture under tensile stress...

  7. 49 CFR 178.705 - Standards for metal IBCs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... a frame with a metal lattice-work casing. (c) Construction requirements for metal IBCs are as... used on fracture under tensile stress (Rm × Ao = 10,000 × 145; if tensile strength is in U.S. Standard...

  8. 78 FR 54485 - Interstate Brands Corporation (IBC); a Wholly Owned Subsidiary of Hostess Brands, Inc.; Including...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-04

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-82,165D] Interstate Brands Corporation (IBC); a Wholly Owned Subsidiary of Hostess Brands, Inc.; Including On-Site Leased Workers From... Brands Corporation (IBC), a wholly owned subsidiary of Hostess Brands, Inc., operating at locations...

  9. 49 CFR 178.708 - Standards for fiberboard IBCs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) Construction requirements for fiberboard IBCs are as follows: (1) Top lifting devices are prohibited in... foot-pounds of energy) measured according to ISO 3036 (IBR, see § 171.7 of this subchapter). (ii.... Where a detachable pallet is used, its top surface must be free from sharp protrusions that might damage...

  10. 49 CFR 178.708 - Standards for fiberboard IBCs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) Construction requirements for fiberboard IBCs are as follows: (1) Top lifting devices are prohibited in... foot-pounds of energy) measured according to ISO 3036 (IBR, see § 171.7 of this subchapter). (ii.... Where a detachable pallet is used, its top surface must be free from sharp protrusions that might damage...

  11. 49 CFR 178.708 - Standards for fiberboard IBCs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) Construction requirements for fiberboard IBCs are as follows: (1) Top lifting devices are prohibited in... foot-pounds of energy) measured according to ISO 3036 (IBR, see § 171.7 of this subchapter). (ii.... Where a detachable pallet is used, its top surface must be free from sharp protrusions that might damage...

  12. 49 CFR 178.708 - Standards for fiberboard IBCs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) Construction requirements for fiberboard IBCs are as follows: (1) Top lifting devices are prohibited in... foot-pounds of energy) measured according to ISO 3036 (IBR, see § 171.7 of this subchapter). (ii.... Where a detachable pallet is used, its top surface must be free from sharp protrusions that might damage...

  13. 49 CFR 178.708 - Standards for fiberboard IBCs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... part of it. (c) Construction requirements for fiberboard IBCs are as follows: (1) Top lifting devices... puncture resistance of 15 Joules (11 foot-pounds of energy) measured according to ISO 3036 (IBR, see § 171... stability in handling and transport. Where a detachable pallet is used, its top surface must be free from...

  14. 49 CFR 178.803 - Testing and certification of IBCs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... IBCs Vibration 6 X 6 X 6 X 6 X 6 X 1.5 X Bottom lift 2 X X X X X Top lift 2 X 2 X 2 X 2,5 X Stacking 7... one of the bottom lift or top lift tests must be performed. 3 The leakproofness and hydrostatic...

  15. 49 CFR 174.63 - Portable tanks, IM portable tanks, IBCs, Large Packagings, cargo tanks, and multi-unit tank car...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Portable tanks, IM portable tanks, IBCs, Large Packagings, cargo tanks, and multi-unit tank car tanks. 174.63 Section 174.63 Transportation Other....63 Portable tanks, IM portable tanks, IBCs, Large Packagings, cargo tanks, and multi-unit tank car...

  16. 49 CFR 174.63 - Portable tanks, IM portable tanks, IBCs, Large Packagings, cargo tanks, and multi-unit tank car...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Portable tanks, IM portable tanks, IBCs, Large Packagings, cargo tanks, and multi-unit tank car tanks. 174.63 Section 174.63 Transportation Other....63 Portable tanks, IM portable tanks, IBCs, Large Packagings, cargo tanks, and multi-unit tank car...

  17. 49 CFR 174.63 - Portable tanks, IM portable tanks, IBCs, Large Packagings, cargo tanks, and multi-unit tank car...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Portable tanks, IM portable tanks, IBCs, Large Packagings, cargo tanks, and multi-unit tank car tanks. 174.63 Section 174.63 Transportation Other....63 Portable tanks, IM portable tanks, IBCs, Large Packagings, cargo tanks, and multi-unit tank car...

  18. 49 CFR 174.63 - Portable tanks, IM portable tanks, IBCs, Large Packagings, cargo tanks, and multi-unit tank car...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Portable tanks, IM portable tanks, IBCs, Large Packagings, cargo tanks, and multi-unit tank car tanks. 174.63 Section 174.63 Transportation Other....63 Portable tanks, IM portable tanks, IBCs, Large Packagings, cargo tanks, and multi-unit tank car...

  19. 49 CFR 174.63 - Portable tanks, IM portable tanks, IBCs, Large Packagings, cargo tanks, and multi-unit tank car...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false Portable tanks, IM portable tanks, IBCs, Large Packagings, cargo tanks, and multi-unit tank car tanks. 174.63 Section 174.63 Transportation Other....63 Portable tanks, IM portable tanks, IBCs, Large Packagings, cargo tanks, and multi-unit tank car...

  20. Anaplastic Lymphoma Kinase Gene Copy Number Gain in Inflammatory Breast Cancer (IBC): Prevalence, Clinicopathologic Features and Prognostic Implication

    PubMed Central

    Kim, Min Hwan; Lee, Soohyeon; Koo, Ja Seung; Jung, Kyung Hae; Park, In Hae; Jeong, Joon; Kim, Seung Il; Park, Seho; Park, Hyung Seok; Park, Byeong-Woo; Kim, Joo-Hang; Sohn, Joohyuk

    2015-01-01

    Background Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer, and its molecular pathogenesis still remains to be elucidated. This study aimed to evaluate the prevalence and implication of anaplastic lymphoma kinase (ALK) copy number change in IBC patients. Methods We retrospectively collected formalin-fixed, paraffin-embedded tumor tissues and medical records of IBC patients from several institutes in Korea. ALK gene copy number change and rearrangement were assessed by fluorescence in situ hybridization (FISH) assay, and ALK expression status was evaluated by immunohistochemical (IHC) staining. Results Thirty-six IBC patients including those with HER2 (+) breast cancer (16/36, 44.4%) and triple-negative breast cancer (13/36, 36.1%) were enrolled in this study. ALK copy number gain (CNG) was observed in 47.2% (17/36) of patients, including one patient who harbored ALK gene amplification. ALK CNG (+) patients showed significantly worse overall survival compared to ALK CNG (-) patients in univariate analysis (24.9 months vs. 38.1 months, p = 0.033). Recurrence free survival (RFS) after curative mastectomy was also significantly shorter in ALK CNG (+) patients than in ALK CNG (-) patients (n = 22, 12.7 months vs. 43.3 months, p = 0.016). Multivariate Cox regression analysis with adjustment for HER2 and ER statuses showed significantly poorer RFS for ALK CNG (+) patients (HR 5.63, 95% CI 1.11–28.44, p = 0.037). Conclusion This study shows a significant presence of ALK CNG in IBC patients, and ALK CNG was associated with significantly poorer RFS. PMID:25803816

  1. Anaplastic lymphoma kinase gene copy number gain in inflammatory breast cancer (IBC): prevalence, clinicopathologic features and prognostic implication.

    PubMed

    Kim, Min Hwan; Lee, Soohyeon; Koo, Ja Seung; Jung, Kyung Hae; Park, In Hae; Jeong, Joon; Kim, Seung Il; Park, Seho; Park, Hyung Seok; Park, Byeong-Woo; Kim, Joo-Hang; Sohn, Joohyuk

    2015-01-01

    Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer, and its molecular pathogenesis still remains to be elucidated. This study aimed to evaluate the prevalence and implication of anaplastic lymphoma kinase (ALK) copy number change in IBC patients. We retrospectively collected formalin-fixed, paraffin-embedded tumor tissues and medical records of IBC patients from several institutes in Korea. ALK gene copy number change and rearrangement were assessed by fluorescence in situ hybridization (FISH) assay, and ALK expression status was evaluated by immunohistochemical (IHC) staining. Thirty-six IBC patients including those with HER2 (+) breast cancer (16/36, 44.4%) and triple-negative breast cancer (13/36, 36.1%) were enrolled in this study. ALK copy number gain (CNG) was observed in 47.2% (17/36) of patients, including one patient who harbored ALK gene amplification. ALK CNG (+) patients showed significantly worse overall survival compared to ALK CNG (-) patients in univariate analysis (24.9 months vs. 38.1 months, p = 0.033). Recurrence free survival (RFS) after curative mastectomy was also significantly shorter in ALK CNG (+) patients than in ALK CNG (-) patients (n = 22, 12.7 months vs. 43.3 months, p = 0.016). Multivariate Cox regression analysis with adjustment for HER2 and ER statuses showed significantly poorer RFS for ALK CNG (+) patients (HR 5.63, 95% CI 1.11-28.44, p = 0.037). This study shows a significant presence of ALK CNG in IBC patients, and ALK CNG was associated with significantly poorer RFS.

  2. A Novel Field-Circuit FEM Modeling and Channel Gain Estimation for Galvanic Coupling Real IBC Measurements.

    PubMed

    Gao, Yue-Ming; Wu, Zhu-Mei; Pun, Sio-Hang; Mak, Peng-Un; Vai, Mang-I; Du, Min

    2016-04-02

    Existing research on human channel modeling of galvanic coupling intra-body communication (IBC) is primarily focused on the human body itself. Although galvanic coupling IBC is less disturbed by external influences during signal transmission, there are inevitable factors in real measurement scenarios such as the parasitic impedance of electrodes, impedance matching of the transceiver, etc. which might lead to deviations between the human model and the in vivo measurements. This paper proposes a field-circuit finite element method (FEM) model of galvanic coupling IBC in a real measurement environment to estimate the human channel gain. First an anisotropic concentric cylinder model of the electric field intra-body communication for human limbs was developed based on the galvanic method. Then the electric field model was combined with several impedance elements, which were equivalent in terms of parasitic impedance of the electrodes, input and output impedance of the transceiver, establishing a field-circuit FEM model. The results indicated that a circuit module equivalent to external factors can be added to the field-circuit model, which makes this model more complete, and the estimations based on the proposed field-circuit are in better agreement with the corresponding measurement results.

  3. 49 CFR 180.350 - Applicability and definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... metal, rigid plastic or composite IBCs produced as a UN type from a non-UN type, or are converted from... subchapter for design type definition). (b) Repaired IBCs are metal, rigid plastic or composite IBCs that, as a result of impact or for any other cause (such as corrosion, embrittlement or other evidence of...

  4. 49 CFR 178.811 - Bottom lift test.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... passing the test. For all IBC design types designed to be lifted from the base, there may be no permanent deformation which renders the IBC unsafe for transportation and no loss of contents. [Amdt. 178-103, 59 FR... bottom lift test. The IBC must be loaded to 1.25 times its maximum permissible gross mass, the load being...

  5. 49 CFR 178.819 - Vibration test.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Vibration test. 178.819 Section 178.819... Vibration test. (a) General. The vibration test must be conducted for the qualification of all rigid IBC design types. Flexible IBC design types must be capable of withstanding the vibration test. (b) Test...

  6. 49 CFR 178.819 - Vibration test.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Vibration test. 178.819 Section 178.819... Vibration test. (a) General. The vibration test must be conducted for the qualification of all rigid IBC design types. Flexible IBC design types must be capable of withstanding the vibration test. (b) Test...

  7. 49 CFR 178.819 - Vibration test.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Vibration test. 178.819 Section 178.819... Vibration test. (a) General. The vibration test must be conducted for the qualification of all rigid IBC design types. Flexible IBC design types must be capable of withstanding the vibration test. (b) Test...

  8. 49 CFR 178.819 - Vibration test.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Vibration test. 178.819 Section 178.819... Vibration test. (a) General. The vibration test must be conducted for the qualification of all rigid IBC design types. Flexible IBC design types must be capable of withstanding the vibration test. (b) Test...

  9. Low temperature surface passivation of crystalline silicon and its application to interdigitated back contact silicon heterojunction (ibc-shj) solar cell

    NASA Astrophysics Data System (ADS)

    Shu, Zhan

    With the absence of shading loss together with improved quality of surface passivation introduced by low temperature processed amorphous silicon crystalline silicon (a-Si:H/c-Si) heterojunction, the interdigitated back contact silicon heterojunction (IBC-SHJ) solar cell exhibits a potential for higher conversion efficiency and lower cost than a traditional front contact diffused junction solar cell. In such solar cells, the front surface passivation is of great importance to achieve both high open-circuit voltage (Voc) and short-circuit current (Jsc). Therefore, the motivation of this work is to develop a low temperature processed structure for the front surface passivation of IBC-SHJ solar cells, which must have an excellent and stable passivation quality as well as a good anti-reflection property. Four different thin film materials/structures were studied and evaluated for this purpose, namely: amorphous silicon nitride (a-SiNx:H), thick amorphous silicon film (a-Si:H), amorphous silicon/silicon nitride/silicon carbide (a-Si:H/a-SiN x:H/a-SiC:H) stack structure with an ultra-thin a-Si:H layer, and zinc sulfide (ZnS). It was demonstrated that the a-Si:H/a-SiNx:H/a-SiC:H stack surpasses other candidates due to both of its excellent surface passivation quality (SRV<5 cm/s) and lower absorption losses. The low recombination rate at the stack structure passivated c-Si surface is found to be resulted from (i) field effect passivation due to the positive fixed charge (Q fix~1x1011 cm-2 with 5 nm a-Si:H layer) in a-SiNx:H as measured from capacitance-voltage technique, and (ii) reduced defect state density (mid-gap Dit~4x1010 cm-2eV-1) at a-Si:H/c-Si interface provided by a 5 nm thick a-Si:H layer, as characterized by conductance-frequency measurements. Paralleled with the experimental studies, a computer program was developed in this work based on the extended Shockley-Read-Hall (SRH) model of surface recombination. With the help of this program, the experimental

  10. 49 CFR 178.801 - General requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... which differs in surface treatment; (ii) A rigid plastic IBC or composite IBC which differs with regard to additives used to comply with §§ 178.706(c), 178.707(c) or 178.710(c); (iii) A packaging which... representative of the type of service equipment that will be fitted to any finished IBC body under the design...

  11. 49 CFR 178.801 - General requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... which differs in surface treatment; (ii) A rigid plastic IBC or composite IBC which differs with regard to additives used to comply with §§ 178.706(c), 178.707(c) or 178.710(c); (iii) A packaging which... representative of the type of service equipment that will be fitted to any finished IBC body under the design...

  12. STS-40 crewmembers use inflight blood collection system (IBCS) kit on middeck

    NASA Technical Reports Server (NTRS)

    1991-01-01

    STS-40 crewmembers follow procedures for Experiment No. 261, The Influence of Space Flight on Erythrokinetics in Man, while on the middeck of Columbia, Orbiter Vehicle (OV) 102. Payload Specialist F. Drew Gaffney (center) draws blood from Payload Specialist Millie Hughes-Fulford (left) as Mission Specialist (MS) James P. Bagian looks on. The crewmembers are using the inflight blood collection system (IBCS) kit in front of the forward lockers and the orbiter refrigerator freezer (ORF). Displayed on the forward lockers are decals representing the Air Force, the Air Force Reserves (AFRES), University of Tennessee, Colorado State, and Stanford University.

  13. 49 CFR 178.811 - Bottom lift test.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... design types designed to be lifted from the base, there may be no permanent deformation which renders the IBC unsafe for transportation and no loss of contents. [Amdt. 178-103, 59 FR 38074, July 26, 1994, as... IBC must be loaded to 1.25 times its maximum permissible gross mass, the load being evenly distributed...

  14. 49 CFR 178.811 - Bottom lift test.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... design types designed to be lifted from the base, there may be no permanent deformation which renders the IBC unsafe for transportation and no loss of contents. [Amdt. 178-103, 59 FR 38074, July 26, 1994, as... IBC must be loaded to 1.25 times its maximum permissible gross mass, the load being evenly distributed...

  15. 49 CFR 178.811 - Bottom lift test.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... design types designed to be lifted from the base, there may be no permanent deformation which renders the IBC unsafe for transportation and no loss of contents. [Amdt. 178-103, 59 FR 38074, July 26, 1994, as... IBC must be loaded to 1.25 times its maximum permissible gross mass, the load being evenly distributed...

  16. 49 CFR 178.811 - Bottom lift test.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... design types designed to be lifted from the base, there may be no permanent deformation which renders the IBC unsafe for transportation and no loss of contents. [Amdt. 178-103, 59 FR 38074, July 26, 1994, as... IBC must be loaded to 1.25 times its maximum permissible gross mass, the load being evenly distributed...

  17. STS-40 crewmembers use inflight blood collection system (IBCS) kit on middeck

    NASA Technical Reports Server (NTRS)

    1991-01-01

    STS-40 crewmembers follow procedures for Experiment No. 261, The Influence of Space Flight on Erythrokinetics in Man, while on the middeck of Columbia, Orbiter Vehicle (OV) 102. Mission Specialist (MS) James P. Bagian (right) draws blood from Payload Specialist F. Drew Gaffney (center) as the second Spacelab Life Sciences 1 (SLS-1) Payload Specialist Millie Hughes-Fulford looks on. The crewmembers are using the inflight blood collection system (IBCS) kit in front of the forward lockers and the orbiter refrigerator freezer (ORF). Displayed on the forward lockers are decals representing the University of Tennessee, Colorado State, and Stanford University and several drink containers.

  18. Design guideline for Si/organic hybrid solar cell with interdigitated back contact structure

    NASA Astrophysics Data System (ADS)

    Bimo Prakoso, Ari; Rusli; Li, Zeyu; Lu, Chenjin; Jiang, Changyun

    2018-03-01

    We study the design of Si/organic hybrid (SOH) solar cells with interdigitated back contact (IBC) structure. SOH solar cells formed between n-Si and poly(3,4-ethylenedioxythiophene): polystyrenesulphonate (PEDOT:PSS) is a promising concept that combines the excellent electronic properties of Si with the solution-based processing advantage of an organic polymer. The IBC cell structure is employed to minimize parasitic absorption losses in the organic polymer, eliminate grid shadowing losses, and allow excellent passivation of the front Si surface in one step over a large area. The influence of Si thickness, doping concentration and contact geometry are simulated in this study to optimize the performance of the SOH-IBC solar cell. We found that a high power conversion efficiency of >20% can be achieved for optimized SOH-IBC cell based on a thin c-Si substrate of 40 μm thickness.

  19. 49 CFR 178.812 - Top lift test.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... renders the IBC, including the base pallets when applicable, unsafe for transportation, and no loss of... twice the maximum permissible gross mass with the load being evenly distributed. (2) Flexible IBC design types must be filled to six times the maximum net mass, the load being evenly distributed. (c) Test...

  20. 49 CFR 178.812 - Top lift test.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... renders the IBC, including the base pallets when applicable, unsafe for transportation, and no loss of... twice the maximum permissible gross mass with the load being evenly distributed. (2) Flexible IBC design types must be filled to six times the maximum net mass, the load being evenly distributed. (c) Test...

  1. 49 CFR 178.812 - Top lift test.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... renders the IBC, including the base pallets when applicable, unsafe for transportation, and no loss of... twice the maximum permissible gross mass with the load being evenly distributed. (2) Flexible IBC design types must be filled to six times the maximum net mass, the load being evenly distributed. (c) Test...

  2. 49 CFR 178.812 - Top lift test.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... renders the IBC, including the base pallets when applicable, unsafe for transportation, and no loss of... twice the maximum permissible gross mass with the load being evenly distributed. (2) Flexible IBC design types must be filled to six times the maximum net mass, the load being evenly distributed. (c) Test...

  3. European project RETAIN: new approach for IBC in teleradiology and PACS based on full ATM network

    NASA Astrophysics Data System (ADS)

    Cordonnier, Emmanuel; Jensch, Peter F.; Piqueras, Joachim; Gandon, Yves

    1995-05-01

    This paper describes the RETAIN project (radiological examination transfer on ATM Integrated Network), which is supported by the European Community, in the frame of the TEN-IBC program (trans-European networks integrated broad band communication). It links together three European sites in France (Rennes), Spain (Barcelona), and Germany (Oldenburg) and involves a partnership between the public national operators France Telecom, Telefonica, and Telekom. One important reason to explicitly consider asynchronous transfer mode (ATM) for medical imaging is that multimedia applications on such networks allow integration of digital data and person-to-person communication. The RETAIN project includes trials of teleworking sessions between radiologists of Rennes and Barcelona within a clinical and/or scientific context based on ATM equipments performing DICOM transfer on examination, digital remote manipulation within a comprehensive dialogue, and high quality visiophony on ATM adaptation layer (AAL) type 1. The project includes also visiophony trials with Oldenburg and preparation of harmonized regional experimentation within an emergency context. The network used is a full 10 Mbits/s ATM network directly connected to local PACSs.

  4. 49 CFR 178.810 - Drop test.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Drop test. 178.810 Section 178.810 Transportation... Drop test. (a) General. The drop test must be conducted for the qualification of all IBC design types... the drop test. (1) Metal, rigid plastic, and composite IBCs intended to contain solids must be filled...

  5. 49 CFR 178.818 - Tear test.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Tear test. 178.818 Section 178.818 Transportation... Tear test. (a) General. The tear test must be conducted for the qualification of all flexible IBC design types. (b) Special preparation for the tear test. The flexible IBC must be filled to not less than...

  6. 49 CFR 178.818 - Tear test.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Tear test. 178.818 Section 178.818 Transportation... § 178.818 Tear test. (a) General. The tear test must be conducted for the qualification of all flexible IBC design types. (b) Special preparation for the tear test. The flexible IBC must be filled to not...

  7. A Carcinogenicity Bioassay of Isobutyl 2-Cyanoacrylate (IBC) in Fischer- 344-Rats--One Year Interim Sacrifice Report. Volume 1

    DTIC Science & Technology

    1988-03-01

    adhesive for use in sutureless wound ial surgery, and in other surgical modality could provide a time-saving and ion to the management of combat... wounds . Dental Research (USAIDR) has been assigned e therapeutic potential of IBC. As part tasked the Toxicology Branch, Letter^an LAIR), to...caged individually in stainless steel wire- mesh cages in racks equipped with automatically flushing dumptanks. No bedding was used in any of the

  8. Warehouse hazardous and toxic waste design in Karingau Balikpapan

    NASA Astrophysics Data System (ADS)

    Pratama, Bayu Rendy; Kencanawati, Martheana

    2017-11-01

    PT. Balikpapan Environmental Services (PT. BES) is company that having core business in Hazardous and Toxic Waste Management Services which consisting storage and transporter at Balikpapan. This research starting with data collection such as type of waste, quantity of waste, dimension area of existing building, waste packaging (Drum, IBC tank, Wooden Box, & Bulk Bag). Processing data that will be done are redesign for warehouse dimension and layout of position waste, specify of capacity, specify of quantity, type and detector placement, specify of quantity, type and fire extinguishers position which refers to Bapedal Regulation No. 01 In 1995, SNI 03-3985-2000, Employee Minister Regulation RI No. Per-04/Men/1980. Based on research that already done, founded the design for warehouse dimension of waste is 23 m × 22 m × 5 m with waste layout position appropriate with type of waste. The necessary of quantity for detector on this waste warehouse design are 56 each. The type of fire extinguisher that appropriate with this design is dry powder which containing natrium carbonate, alkali salts, with having each weight of 12 Kg about 18 units.

  9. 49 CFR 173.35 - Hazardous materials in IBCs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., cracks, cuts, or other damage which would render it unable to pass the prescribed design type test to... of this subchapter. Additional marking allowed for each design type may be present. Required markings... percent of its water capacity. (e) Where two or more closure systems are fitted in series, the system...

  10. 49 CFR 178.706 - Standards for rigid plastic IBCs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... than production residues or regrind from the same manufacturing process may be used in the manufacture... those used in the manufacture of the tested design type, retesting may be omitted if changes in the... types are designated: (1) 11H1 fitted with structural equipment designed to withstand the whole load...

  11. Implementation of a Helicopter Flight Simulator with Individual Blade Control

    NASA Astrophysics Data System (ADS)

    Zinchiak, Andrew G.

    2011-12-01

    Nearly all modern helicopters are designed with a swashplate-based system for control of the main rotor blades. However, the swashplate-based approach does not provide the level of redundancy necessary to cope with abnormal actuator conditions. For example, if an actuator fails (becomes locked) on the main rotor, the cyclic inputs are consequently fixed and the helicopter may become stuck in a flight maneuver. This can obviously be seen as a catastrophic failure, and would likely lead to a crash. These types of failures can be overcome with the application of individual blade control (IBC). IBC is achieved using the blade pitch control method, which provides complete authority of the aerodynamic characteristics of each rotor blade at any given time by replacing the normally rigid pitch links between the swashplate and the pitch horn of the blade with hydraulic or electronic actuators. Thus, IBC can provide the redundancy necessary for subsystem failure accommodation. In this research effort, a simulation environment is developed to investigate the potential of the IBC main rotor configuration for fault-tolerant control. To examine the applications of IBC to failure scenarios and fault-tolerant controls, a conventional, swashplate-based linear model is first developed for hover and forward flight scenarios based on the UH-60 Black Hawk helicopter. The linear modeling techniques for the swashplate-based helicopter are then adapted and expanded to include IBC. Using these modified techniques, an IBC based mathematical model of the UH-60 helicopter is developed for the purposes of simulation and analysis. The methodology can be used to model and implement a different aircraft if geometric, gravimetric, and general aerodynamic data are available. Without the kinetic restrictions of the swashplate, the IBC model effectively decouples the cyclic control inputs between different blades. Simulations of the IBC model prove that the primary control functions can be manually

  12. 49 CFR 178.702 - IBC codes.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... solids, discharged by gravity Under pressure of more than 10 kPa (1.45 psig) For liquids Rigid 11 21 31 Flexible 13 (2) Intermediate bulk container code letter designations are as follows: “A” means steel (all types and surface treatments). “B” means aluminum. “C” means natural wood. “D” means plywood. “F” means...

  13. SN 1994I in M51 and the nature of type Ibc supernovae

    NASA Technical Reports Server (NTRS)

    Wheeler, J. C.; Harkness, R. P.; Clocchiatti, A.; Benetti, S.; Brotherton, M. S.; Depoy, D. L.; Elias, J.

    1994-01-01

    Early spectra of SN 1994I in M51 (NGC 5194) are presented along with arguments that is a member of the class of helium-poor Type Ic supernovae. The issue of H and He in the spectra of Type Ib and Ic events is reexamined with the conclusion that Type Ib eject substantially less H than even transition events like SN 1993J and that Type Ic eject substantially less He than Type Ib and their optical spectra are consistent with no H or He. Type Ic show and absorption of the Si II lambda 6355 blend that characterizes Type Ia. This feature requires only a solar abundance of Si. Some Type Ic show an absorption that is probably C II lambda 6580. IR spectra are presented of SN 1990W which show the line of He I lambda 10830. The strength of this feature and the rather slow decay of the late time light curve suggest that this event could be better classified as a Type Ib. Even if trace abundances of H are present in Type Ib and of He in Type Ic the spectral differences still imply a distinctly different evolution for the progenitors of Type Ib from Type Ic and events like SN 1993J.

  14. Scaled accelerographs for design of structures in Quetta, Baluchistan, Pakistan

    NASA Astrophysics Data System (ADS)

    Bhatti, Abdul Qadir

    2016-12-01

    Structural design for seismic excitation is usually based on peak values of forces and deformations over the duration of earthquake. In determining these peak values dynamic analysis is done which requires either response history analysis (RHA), also called time history analysis, or response spectrum analysis (RSA), both of which depend upon ground motion severity. In the past, PGA has been used to describe ground motion severity, because seismic force on a rigid body is proportional to the ground acceleration. However, it has been pointed out that single highest peak on accelerograms is a very unreliable description of the accelerograms as a whole. In this study, we are considering 0.2- and 1-s spectral acceleration. Seismic loading has been defined in terms of design spectrum and time history which will lead us to two methods of dynamic analysis. Design spectrum for Quetta will be constructed incorporating the parameters of ASCE 7-05/IBC 2006/2009, which is being used by modern codes and regulation of the world like IBC 2006/2009, ASCE 7-05, ATC-40, FEMA-356 and others. A suite of time history representing design earthquake will also be prepared, this will be a helpful tool to carryout time history dynamic analysis of structures in Quetta.

  15. Human cardiovascular disease IBC chip-wide association with weight loss and weight regain in the look AHEAD trial.

    PubMed

    McCaffery, Jeanne M; Papandonatos, George D; Huggins, Gordon S; Peter, Inga; Erar, Bahar; Kahn, Steven E; Knowler, William C; Lipkin, Edward W; Kitabchi, Abbas E; Wagenknecht, Lynne E; Wing, Rena R

    2013-01-01

    The present study identified genetic predictors of weight change during behavioral weight loss treatment. Participants were 3,899 overweight/obese individuals with type 2 diabetes from Look AHEAD, a randomized controlled trial to determine the effects of intensive lifestyle intervention (ILI), including weight loss and physical activity, relative to diabetes support and education, on cardiovascular outcomes. Analyses focused on associations of single nucleotide polymorphisms (SNPs) on the Illumina CARe iSelect (IBC) chip (minor allele frequency >5%; n = 31,959) with weight change at year 1 and year 4, and weight regain at year 4, among individuals who lost ≥ 3% at year 1. Two novel regions of significant chip-wide association with year-1 weight loss in ILI were identified (p < 2.96E-06). ABCB11 rs484066 was associated with 1.16 kg higher weight per minor allele at year 1, whereas TNFRSF11A, or RANK, rs17069904 was associated with 1.70 kg lower weight per allele at year 1. This study, the largest to date on genetic predictors of weight loss and regain, indicates that SNPs within ABCB11, related to bile salt transfer, and TNFRSF11A, implicated in adipose tissue physiology, predict the magnitude of weight loss during behavioral intervention. These results provide new insights into potential biological mechanisms and may ultimately inform weight loss treatment. © 2013 S. Karger AG, Basel.

  16. 49 CFR 178.813 - Leakproofness test.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... vent must be sealed. For metal IBC design types, the initial test must be carried out before the... the seams and joints with a heavy oil, a soap solution and water, or other methods suitable for the...

  17. Modeling for intra-body communication with bone effect.

    PubMed

    Pun, S H; Gao, Y M; Mak, P U; Du, M; Vai, M I

    2009-01-01

    Intra-body communication (IBC) is a new, different "wireless" communication technique based on the human tissue. This short range "wireless" communication technology provides an alternative solution to wearable sensors, home health system, telemedicine and implanted devices. The development of the IBC enables the possibilities of providing less complexity and convenient communication methodologies for these devices. By regarding human tissue as communication channel, IBC making use of the conductivities properties of human tissue to send electrical signal from transmitter to receiver. In this paper, the authors proposed a new mathematical model for galvanic coupling type IBC based on a human limb. Starting from the electromagnetic theory, the authors treat human tissue as volume conductor, which is in analogous with the bioelectric phenomena analysis. In order to explain the mechanism of galvanic coupling type technique of IBC, applying the quasi-static approximation, the governing equation can be reduced to Laplace Equation. Finally, the analytical model is evaluated with on-body measurement for testing its performance. The comparison result shows that the developed mathematical model can provide good approximation for galvanic coupling type IBC on human limb under low operating frequencies.

  18. Technology computer aided design of 29.5% efficient perovskite/interdigitated back contact silicon heterojunction mechanically stacked tandem solar cell for energy-efficient applications

    NASA Astrophysics Data System (ADS)

    Pandey, Rahul; Chaujar, Rishu

    2017-04-01

    A 29.5% efficient perovskite/SiC passivated interdigitated back contact silicon heterojunction (IBC-SiHJ) mechanically stacked tandem solar cell device has been designed and simulated. This is a substantial improvement of 40% and 15%, respectively, compared to the transparent perovskite solar cell (21.1%) and Si solar cell (25.6%) operated individually. The perovskite solar cell has been used as a top subcell, whereas 250- and 25-μm-thick IBC-SiHJ solar cells have been used as bottom subcells. The realistic technology computer aided design analysis has been performed to understand the physical processes in the device and to make reliable predictions of the behavior. The performance of the top subcell has been obtained for different acceptor densities and hole mobility in Spiro-MeOTAD along with the impact of counter electrode work function. To incorporate the effect of material quality, the influence of carrier lifetimes has also been studied for perovskite top and IBC-SiHJ bottom subcells. The optical and electrical behavior of the devices has been obtained for both standalone as well as tandem configuration. Results reported in this study reveal that the proposed four-terminal tandem device may open a new door for cost-effective and energy-efficient applications.

  19. 14 CFR 21.31 - Type design.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Type design. 21.31 Section 21.31... PROCEDURES FOR PRODUCTS AND PARTS Type Certificates § 21.31 Type design. The type design consists of— (a) The... configuration and the design features of the product shown to comply with the requirements of that part of this...

  20. BIM-EL localization: The key to understanding anoikis resistance in inflammatory breast cancer cells.

    PubMed

    Buchheit, Cassandra L; Schafer, Zachary T

    2016-01-01

    Inflammatory breast cancer (IBC) is a highly metastatic and rare type of breast cancer, accounting for 2-6% of newly diagnosed breast cancer cases each year. The highly metastatic nature of IBC cells remains poorly understood. Here we describe our recent data regarding the ability of IBC cells to overcome anoikis.

  1. Simple electrical model and initial experiments for intra-body communications.

    PubMed

    Gao, Y M; Pun, S H; Du, M; Mak, P U; Vai, M I

    2009-01-01

    Intra-Body Communication(IBC) is a short range "wireless" communication technique appeared in recent years. This technique relies on the conductive property of human tissue to transmit the electric signal among human body. This is beneficial for devices networking and sensors among human body, and especially suitable for wearable sensors, telemedicine system and home health care system as in general the data rates of physiologic parameters are low. In this article, galvanic coupling type IBC application on human limb was investigated in both its mathematical model and related experiments. The experimental results showed that the proposed mathematical model was capable in describing the galvanic coupling type IBC under low frequency. Additionally, the calculated result and experimental result also indicated that the electric signal induced by the transmitters of IBC can penetrate deep into human muscle and thus, provide an evident that IBC is capable of acting as networking technique for implantable devices.

  2. 49 CFR 178.812 - Top lift test.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... no loss of contents. [Amdt. 178-103, 59 FR 38074, July 26, 1994, as amended at 66 FR 33452, June 21... types must be loaded to twice the maximum permissible gross mass with the load being evenly distributed. (2) Flexible IBC design types must be filled to six times the maximum net mass, the load being evenly...

  3. Association of Inflammatory and Non-Inflammatory Breast Cancer with Socioeconomic Characteristics in the Surveillance, Epidemiology, and End Results Database, 2000–2007

    PubMed Central

    Schlichting, Jennifer A.; Soliman, Amr S.; Schairer, Catherine; Banerjee, Mousumi; Rozek, Laura S.; Schottenfeld, David; Harford, Joe B.; Merajver, Sofia D.

    2011-01-01

    Background Inflammatory breast cancer (IBC) is a rare and highly aggressive form of primary breast cancer. Little is known regarding risk factors for IBC, specifically the association with socioeconomic position (SEP). Methods The association between breast cancer type (IBC vs. non-IBC) with county-level SEP in the Surveillance, Epidemiology, and End Results database for cases diagnosed from 2000–2007 was examined. County-level SEP characteristics included metropolitan vs. non- metropolitan residence, percent below the poverty level, percent less than high school graduate,and an index combining the poverty and high school variables. IBC and non-IBC age-adjusted incidence rates (IRs) were calculated, stratified on SEP and race/ethnicity. The odds of IBC vs. non-IBC given a particular SEP characteristic, adjusting for age and race/ethnicity, was examined through fitting of hierarchical logistic regression models (HLMs). Results IRs for IBC generally increased as SEP decreased, while the opposite was found for non-IBC. HLM results showed low SEP is associated with higher odds of IBC: Highest (≥ 20%) vs. lowest (<10%) persons below the poverty level Odds Ratio (95% Confidence Interval) = 1.25 (1.09–1.43); Highest (>28.76%) vs. lowest (≤15.99%) persons less than high school graduate = 1.25 (1.10–1.42); Low SEP as measured by poverty-high school index vs. high SEP = 1.26 (1.11–1.44). Conclusion Overall breast cancer has been found to be positively associated with SEP, whereas in this analysis IBC was associated with decreasing SEP. Impact Studies focused on understanding the disparity in IBC incidence, as well as interventions to eliminate these differences are needed. PMID:22028401

  4. Hyperactivated mTOR and JAK2/STAT3 Pathways: Molecular Drivers and Potential Therapeutic Targets of Inflammatory and Invasive Ductal Breast Cancers After Neoadjuvant Chemotherapy.

    PubMed

    Jhaveri, Komal; Teplinsky, Eleonora; Silvera, Deborah; Valeta-Magara, Amanda; Arju, Rezina; Giashuddin, Shah; Sarfraz, Yasmeen; Alexander, Melissa; Darvishian, Farbod; Levine, Paul H; Hashmi, Salman; Zolfaghari, Ladan; Hoffman, Heather J; Singh, Baljit; Goldberg, Judith D; Hochman, Tsivia; Formenti, Silvia; Esteva, Francisco J; Moran, Meena S; Schneider, Robert J

    2016-04-01

    Inflammatory breast cancer (IBC) is an aggressive and rare cancer with a poor prognosis and a need for novel targeted therapeutic strategies. Preclinical IBC data showed strong activation of the phosphatidylinositide-3-kinase/mammalian target of rapamycin (mTOR) and Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways, and expression of inflammatory cytokines and tumor-associated macrophages (TAMs). Archival tumor tissue from 3 disease types (IBC treated with neoadjuvant chemotherapy [NAC], n = 45; invasive ductal carcinoma [IDC] treated with NAC [n = 24; 'treated IDC'; and untreated IDC [n = 27; 'untreated IDC']) was analyzed for the expression of biomarkers phospho-S6 (pS6) (mTOR), phospho-JAK2 (pJAK2), pSTAT3, interleukin (IL)-6, CD68 (monocytes, macrophages), and CD163 (TAMs). Surrounding nontumor tissue was also analyzed. Biomarker levels and surrogate activity according to site-specific phosphorylation were shown in the tumor tissue of all 3 disease types but were greatest in IBC and treated IDC and least in untreated IDC for pS6, pJAK2, pSTAT3, and IL-6. Of 37 IBC patients with complete biomarker data available, 100% were pS6-positive and 95% were pJAK2-positive. In nontumor tissue, biomarker levels were observed in all groups but were generally greatest in untreated IDC and least in IBC, except for JAK2. IBC and treated IDC display similar levels of mTOR and JAK2 biomarker activation, which suggests a potential mechanism of resistance after NAC. Biomarker levels in surrounding nontumor tissue suggested that the stroma might be activated by chemotherapy and resembles the oncogenic tumor-promoting environment. Activation of pS6 and pJAK2 in IBC might support dual targeting of the mTOR and JAK/STAT pathways, and the need for prospective studies to investigate combined targeted therapies in IBC. Copyright © 2016 Elsevier Inc. All rights reserved.

  5. All-back-Schottky-contact thin-film photovoltaics

    NASA Astrophysics Data System (ADS)

    Nardone, Marco

    2016-02-01

    The concept of All-Back-Schottky-Contact (ABSC) thin-film photovoltaic (TFPV) devices is introduced and evaluated using 2D numerical simulation. Reach-through Schottky junctions due to two metals of different work functions in an alternating, side-by-side pattern along the non-illuminated side generate the requisite built-in field. It is shown that our simulation method quantitatively describes existing data for a recently demonstrated heterojunction thin-film cell with interdigitated back contacts (IBCs) of one metal type. That model is extended to investigate the performance of ABSC devices with bimetallic IBCs within a pertinent parameter space. Our calculations indicate that 20% efficiency is achievable with micron-scale features and sufficient surface passivation. Bimetallic, micron-scale IBCs are readily fabricated using photo-lithographic techniques and the ABSC design allows for optically transparent surface passivation layers that need not be electrically conductive. The key advantages of the ABSC-TFPV architecture are that window layers, buffer layers, heterojunctions, and module scribing are not required because both contacts are located on the back of the device.

  6. Anoikis evasion in inflammatory breast cancer cells is mediated by Bim-EL sequestration

    PubMed Central

    Buchheit, C L; Angarola, B L; Steiner, A; Weigel, K J; Schafer, Z T

    2015-01-01

    Inflammatory breast cancer (IBC) is a rare and highly invasive type of breast cancer, and patients diagnosed with IBC often face a very poor prognosis. IBC is characterized by the lack of primary tumor formation and the rapid accumulation of cancerous epithelial cells in the dermal lymphatic vessels. Given that normal epithelial cells require attachment to the extracellular matrix (ECM) for survival, a comprehensive examination of the molecular mechanisms underlying IBC cell survival in the lymphatic vessels is of paramount importance to our understanding of IBC pathogenesis. Here we demonstrate that, in contrast to normal mammary epithelial cells, IBC cells evade ECM-detachment-induced apoptosis (anoikis). ErbB2 and EGFR knockdown in KPL-4 and SUM149 cells, respectively, causes decreased colony growth in soft agar and increased caspase activation following ECM detachment. ERK/MAPK signaling was found to operate downstream of ErbB2 and EGFR to protect cells from anoikis by facilitating the formation of a protein complex containing Bim-EL, LC8, and Beclin-1. This complex forms as a result of Bim-EL phosphorylation on serine 59, and thus Bim-EL cannot localize to the mitochondria and cause anoikis. These results reveal a novel mechanism that could be targeted with innovative therapeutics to induce anoikis in IBC cells. PMID:25526094

  7. Anoikis evasion in inflammatory breast cancer cells is mediated by Bim-EL sequestration.

    PubMed

    Buchheit, C L; Angarola, B L; Steiner, A; Weigel, K J; Schafer, Z T

    2015-08-01

    Inflammatory breast cancer (IBC) is a rare and highly invasive type of breast cancer, and patients diagnosed with IBC often face a very poor prognosis. IBC is characterized by the lack of primary tumor formation and the rapid accumulation of cancerous epithelial cells in the dermal lymphatic vessels. Given that normal epithelial cells require attachment to the extracellular matrix (ECM) for survival, a comprehensive examination of the molecular mechanisms underlying IBC cell survival in the lymphatic vessels is of paramount importance to our understanding of IBC pathogenesis. Here we demonstrate that, in contrast to normal mammary epithelial cells, IBC cells evade ECM-detachment-induced apoptosis (anoikis). ErbB2 and EGFR knockdown in KPL-4 and SUM149 cells, respectively, causes decreased colony growth in soft agar and increased caspase activation following ECM detachment. ERK/MAPK signaling was found to operate downstream of ErbB2 and EGFR to protect cells from anoikis by facilitating the formation of a protein complex containing Bim-EL, LC8, and Beclin-1. This complex forms as a result of Bim-EL phosphorylation on serine 59, and thus Bim-EL cannot localize to the mitochondria and cause anoikis. These results reveal a novel mechanism that could be targeted with innovative therapeutics to induce anoikis in IBC cells.

  8. New "Risk-Targeted" Seismic Maps Introduced into Building Codes

    USGS Publications Warehouse

    Luco, Nicholas; Garrett, B.; Hayes, J.

    2012-01-01

    Throughout most municipalities of the United States, structural engineers design new buildings using the U.S.-focused International Building Code (IBC). Updated editions of the IBC are published every 3 years. The latest edition (2012) contains new "risk-targeted maximum considered earthquake" (MCER) ground motion maps, which are enabling engineers to incorporate a more consistent and better defined level of seismic safety into their building designs.

  9. Flood type specific construction of synthetic design hydrographs

    NASA Astrophysics Data System (ADS)

    Brunner, Manuela I.; Viviroli, Daniel; Sikorska, Anna E.; Vannier, Olivier; Favre, Anne-Catherine; Seibert, Jan

    2017-02-01

    Accurate estimates of flood peaks, corresponding volumes, and hydrographs are required to design safe and cost-effective hydraulic structures. In this paper, we propose a statistical approach for the estimation of the design variables peak and volume by constructing synthetic design hydrographs for different flood types such as flash-floods, short-rain floods, long-rain floods, and rain-on-snow floods. Our approach relies on the fitting of probability density functions to observed flood hydrographs of a certain flood type and accounts for the dependence between peak discharge and flood volume. It makes use of the statistical information contained in the data and retains the process information of the flood type. The method was tested based on data from 39 mesoscale catchments in Switzerland and provides catchment specific and flood type specific synthetic design hydrographs for all of these catchments. We demonstrate that flood type specific synthetic design hydrographs are meaningful in flood-risk management when combined with knowledge on the seasonality and the frequency of different flood types.

  10. Characterization of Impulse Radio Intrabody Communication System for Wireless Body Area Networks.

    PubMed

    Cai, Zibo; Seyedi, MirHojjat; Zhang, Weiwei; Rivet, Francois; Lai, Daniel T H

    2017-01-01

    Intrabody communication (IBC) is a promising data communication technique for body area networks. This short-distance communication approach uses human body tissue as the medium of signal propagation. IBC is defined as one of the physical layers for the new IEEE 802.15.6 or wireless body area network (WBAN) standard, which can provide a suitable data rate for real-time physiological data communication while consuming lower power compared to that of radio-frequency protocols such as Bluetooth. In this paper, impulse radio (IR) IBC (IR-IBC) is examined using a field-programmable gate array (FPGA) implementation of an IBC system. A carrier-free pulse position modulation (PPM) scheme is implemented using an IBC transmitter in an FPGA board. PPM is a modulation technique that uses time-based pulse characteristics to encode data based on IR concepts. The transmission performance of the scheme was evaluated through signal propagation measurements of the human arm using 4- and 8-PPM transmitters, respectively. 4 or 8 is the number of symbols during modulations. It was found that the received signal-to-noise ratio (SNR) decreases approximately 8.0 dB for a range of arm distances (5-50 cm) between the transmitter and receiver electrodes with constant noise power and various signal amplitudes. The SNR for the 4-PPM scheme is approximately 2 dB higher than that for the 8-PPM one. In addition, the bit error rate (BER) is theoretically analyzed for the human body channel with additive white Gaussian noise. The 4- and 8-PPM IBC systems have average BER values of 10 -5 and 10 -10 , respectively. The results indicate the superiority of the 8-PPM scheme compared to the 4-PPM one when implementing the IBC system. The performance evaluation of the proposed IBC system will improve further IBC transceiver design.

  11. Design and application of ion-implanted polySi passivating contacts for interdigitated back contact c-Si solar cells

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yang, Guangtao; Ingenito, Andrea; Hameren, Nienke van

    2016-01-18

    Ion-implanted passivating contacts based on poly-crystalline silicon (polySi) are enabled by tunneling oxide, optimized, and used to fabricate interdigitated back contact (IBC) solar cells. Both n-type (phosphorous doped) and p-type (boron doped) passivating contacts are fabricated by ion-implantation of intrinsic polySi layers deposited via low-pressure chemical vapor deposition and subsequently annealed. The impact of doping profile on the passivation quality of the polySi doped contacts is studied for both polarities. It was found that an excellent surface passivation could be obtained by confining as much as possible the implanted-and-activated dopants within the polySi layers. The doping profile in the polySimore » was controlled by modifying the polySi thickness, the energy and dose of ion-implantation, and the temperature and time of annealing. An implied open-circuit voltage of 721 mV for n-type and 692 mV for p-type passivating contacts was achieved. Besides the high passivating quality, the developed passivating contacts exhibit reasonable high conductivity (R{sub sh n-type} = 95 Ω/□ and R{sub sh p-type} = 120 Ω/□). An efficiency of 19.2% (V{sub oc} = 673 mV, J{sub sc} = 38.0 mA/cm{sup 2}, FF = 75.2%, and pseudo-FF = 83.2%) was achieved on a front-textured IBC solar cell with polySi passivating contacts as both back surface field and emitter. By improving the front-side passivation, a V{sub OC} of 696 mV was also measured.« less

  12. 49 CFR 178.817 - Righting test.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Righting test. 178.817 Section 178.817... Righting test. (a) General. The righting test must be conducted for the qualification of all flexible IBCs designed to be lifted from the top or side. (b) Special preparation for the righting test. The flexible IBC...

  13. Polysaccharide capsule and sialic acid-mediated regulation promote biofilm-like intracellular bacterial communities during cystitis.

    PubMed

    Anderson, Gregory G; Goller, Carlos C; Justice, Sheryl; Hultgren, Scott J; Seed, Patrick C

    2010-03-01

    Uropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections (UTIs). A murine UTI model has revealed an infection cascade whereby UPEC undergoes cycles of invasion of the bladder epithelium, intracellular proliferation in polysaccharide-containing biofilm-like masses called intracellular bacterial communities (IBC), and then dispersal into the bladder lumen to initiate further rounds of epithelial colonization and invasion. We predicted that the UPEC K1 polysaccharide capsule is a key constituent of the IBC matrix. Compared to prototypic E. coli K1 strain UTI89, a capsule assembly mutant had a fitness defect in functionally TLR4(+) and TLR4(-) mice, suggesting a protective role of capsule in inflamed and noninflamed hosts. K1 capsule assembly and synthesis mutants had dramatically reduced IBC formation, demonstrating the common requirement for K1 polysaccharide in IBC development. The capsule assembly mutant appeared dispersed in the cytoplasm of the bladder epithelial cells and failed to undergo high-density intracellular replication during later stages of infection, when the wild-type strain continued to form serial generations of IBC. Deletion of the sialic acid regulator gene nanR partially restored IBC formation in the capsule assembly mutant. These data suggest that capsule is necessary for efficient IBC formation and that aberrant sialic acid accumulation, resulting from disruption of K1 capsule assembly, produces a NanR-mediated defect in intracellular proliferation and IBC development. Together, these data demonstrate the complex but important roles of UPEC polysaccharide encapsulation and sialic acid signaling in multiple stages of UTI pathogenesis.

  14. Investigation of Rotor Performance and Loads of a UH-60A Individual Blade Control System

    NASA Technical Reports Server (NTRS)

    Yeo, Hyeonsoo; Romander, Ethan A.; Norman, Thomas R.

    2010-01-01

    A full-scale wind tunnel test was recently conducted (March 2009) in the National Full-Scale Aerodynamics Complex (NFAC) 40- by 80-FootWind Tunnel to evaluate the potential of an individual blade control (IBC) system to improve rotor performance and reduce vibrations, loads, and noise for a UH-60A rotor system [1]. This test was the culmination of a long-termcollaborative effort between NASA, U.S. Army, Sikorsky Aircraft Corporation, and ZF Luftfahrttechnik GmbH (ZFL) to demonstrate the benefits of IBC for a UH-60Arotor. Figure 1 shows the UH-60Arotor and IBC system mounted on the NFAC Large Rotor Test Apparatus (LRTA). The IBC concept used in the current study utilizes actuators placed in the rotating frame, one per blade. In particular, the pitch link of the rotor blade was replacedwith an actuator, so that the blade root pitch can be changed independently. This concept, designed for a full-scale UH-60A rotor, was previously tested in the NFAC 80- by 120-FootWind Tunnel in September 2001 at speeds up to 85 knots [2]. For the current test, the same UH-60A rotor and IBC system were tested in the 40- by 80-FootWind Tunnel at speeds up to 170 knots. Figure 2 shows the servo-hydraulic IBC actuator installed between the swashplate and the blade pitch horn. Although previous wind tunnel experiments [3, 4] and analytical studies on IBC [5, 6] have shown the promise to improve the rotor s performance, in-depth correlation studies have not been performed. Thus, the current test provides a unique resource that can be used to assess the accuracy and reliability of prediction methods and refine theoretical models, with the ultimate goal of providing the technology for timely and cost-effective design and development of new rotors. In this paper, rotor performance and loads calculations are carried out using the analyses CAMRAD II and coupled OVERFLOW-2/CAMRAD II and the results are compared with these UH-60A/IBC wind tunnel test data.

  15. Design of a finger base-type pulse oximeter

    NASA Astrophysics Data System (ADS)

    Lin, Bor-Shyh; Huang, Cheng-Yang; Chen, Chien-Yue; Lin, Jiun-Hung

    2016-01-01

    A pulse oximeter is a common medical instrument used for noninvasively monitoring arterial oxygen saturation (SpO2). Currently, the fingertip-type pulse oximeter is the prevalent type of pulse oximeter used. However, it is inconvenient for long-term monitoring, such as that under motion. In this study, a wearable and wireless finger base-type pulse oximeter was designed and implemented using the tissue optical simulation technique and the Monte Carlo method. The results revealed that a design involving placing the light source at 135°-165° and placing the detector at 75°-90° or 90°-105° yields the optimal conditions for measuring SpO2. Finally, the wearable and wireless finger base-type pulse oximeter was implemented and compared with the commercial fingertip-type pulse oximeter. The experimental results showed that the proposed optimal finger base-type pulse oximeter design can facilitate precise SpO2 measurement.

  16. Design of a finger base-type pulse oximeter.

    PubMed

    Lin, Bor-Shyh; Huang, Cheng-Yang; Chen, Chien-Yue; Lin, Jiun-Hung

    2016-01-01

    A pulse oximeter is a common medical instrument used for noninvasively monitoring arterial oxygen saturation (SpO2). Currently, the fingertip-type pulse oximeter is the prevalent type of pulse oximeter used. However, it is inconvenient for long-term monitoring, such as that under motion. In this study, a wearable and wireless finger base-type pulse oximeter was designed and implemented using the tissue optical simulation technique and the Monte Carlo method. The results revealed that a design involving placing the light source at 135°-165° and placing the detector at 75°-90° or 90°-105° yields the optimal conditions for measuring SpO2. Finally, the wearable and wireless finger base-type pulse oximeter was implemented and compared with the commercial fingertip-type pulse oximeter. The experimental results showed that the proposed optimal finger base-type pulse oximeter design can facilitate precise SpO2 measurement.

  17. 14 CFR 21.93 - Classification of changes in type design.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Classification of changes in type design... TRANSPORTATION AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Changes to Type Certificates § 21.93 Classification of changes in type design. (a) In addition to changes in type design specified in paragraph (b) of...

  18. Inflammatory breast cancer in North Africa: Comparison of clinical and molecular epidemiologic characteristics of patients from Egypt, Tunisia, and Morocco

    PubMed Central

    Soliman, Amr S.; Kleer, Celina G.; Mrad, Karima; Karkouri, Mehdi; Omar, Sherif; Khaled, Hussein M.; Benider, Abdel-Latif; Ayed, Farhat Ben; Eissa, Saad S.; Eissa, Mohab S.; McSpadden, Erin J.; Lo, An-Chi; Toy, Kathy; Kantor, Elizabeth D.; Xiao, Quin; Hampton, Claire; Merajver, Sofia D.

    2014-01-01

    Understanding molecular characteristics that distinguish inflammatory breast cancer (IBC) from non-IBC is crucial for elucidating breast cancer etiology and management. We included 3 sets of patients from Egypt (48 IBC and 64 non-IBC), Tunisia (24 IBC and 40 non-IBC), and Morocco (42 IBC and 41 non-IBC). Egyptian IBC patients had the highest combined erythema, edema, peau d'orange, and metastasis among the 3 IBC groups. Egyptian IBC tumors had the highest RhoC expression than Tunisians and Moroccan IBCs (87% vs. 50%, vs. 38.1, for the 3 countries, respectively). Tumor emboli were more frequent in Egyptian IBC than non-IBC (Mean ±SD: 14.1 ± 14.0 vs. 7.0 ± 12.9, respectively) (P < 0.001) and Tunisians (Mean ± SD: 3.4 ± 2.5 vs. 1.9 ± 2.0, respectively) (P < 0.01). There was no difference of emboli in Moroccan tumors (1.7 ± 1.2 vs. 1.8 ± 1.2 for IBC and non-IBC, respectively (P = 0.66). This study illustrates that RhoC overexpression and tumor emboli are more frequent in IBC relative to non-IBC from Egypt and Tunisia. Tumors of Moroccans were significantly different from Egyptian and Tunisian tumors for RhoC expression and emboli. Future studies should focus on relating epidemiologic factors and clinical pictures to molecular features of IBC in these and other populations. PMID:23001584

  19. Uncovering the molecular secrets of inflammatory breast cancer biology: an integrated analysis of three distinct affymetrix gene expression datasets.

    PubMed

    Van Laere, Steven J; Ueno, Naoto T; Finetti, Pascal; Vermeulen, Peter; Lucci, Anthony; Robertson, Fredika M; Marsan, Melike; Iwamoto, Takayuki; Krishnamurthy, Savitri; Masuda, Hiroko; van Dam, Peter; Woodward, Wendy A; Viens, Patrice; Cristofanilli, Massimo; Birnbaum, Daniel; Dirix, Luc; Reuben, James M; Bertucci, François

    2013-09-01

    Inflammatory breast cancer (IBC) is a poorly characterized form of breast cancer. So far, the results of expression profiling in IBC are inconclusive due to various reasons including limited sample size. Here, we present the integration of three Affymetrix expression datasets collected through the World IBC Consortium allowing us to interrogate the molecular profile of IBC using the largest series of IBC samples ever reported. Affymetrix profiles (HGU133-series) from 137 patients with IBC and 252 patients with non-IBC (nIBC) were analyzed using unsupervised and supervised techniques. Samples were classified according to the molecular subtypes using the PAM50-algorithm. Regression models were used to delineate IBC-specific and molecular subtype-independent changes in gene expression, pathway, and transcription factor activation. Four robust IBC-sample clusters were identified, associated with the different molecular subtypes (P<0.001), all of which were identified in IBC with a similar prevalence as in nIBC, except for the luminal A subtype (19% vs. 42%; P<0.001) and the HER2-enriched subtype (22% vs. 9%; P<0.001). Supervised analysis identified and validated an IBC-specific, molecular subtype-independent 79-gene signature, which held independent prognostic value in a series of 871 nIBCs. Functional analysis revealed attenuated TGF-β signaling in IBC. We show that IBC is transcriptionally heterogeneous and that all molecular subtypes described in nIBC are detectable in IBC, albeit with a different frequency. The molecular profile of IBC, bearing molecular traits of aggressive breast tumor biology, shows attenuation of TGF-β signaling, potentially explaining the metastatic potential of IBC tumor cells in an unexpected manner. ©2013 AACR.

  20. 49 CFR 451.12 - Application for approval by design type.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 6 2013-10-01 2013-10-01 false Application for approval by design type. 451.12... Approval of New Containers § 451.12 Application for approval by design type. (a) For approval of new containers by design type, each application must include the following: (1) Engineering drawings and plans...

  1. 49 CFR 451.12 - Application for approval by design type.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 6 2014-10-01 2014-10-01 false Application for approval by design type. 451.12... Approval of New Containers § 451.12 Application for approval by design type. (a) For approval of new containers by design type, each application must include the following: (1) Engineering drawings and plans...

  2. 49 CFR 451.12 - Application for approval by design type.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 6 2012-10-01 2012-10-01 false Application for approval by design type. 451.12... Approval of New Containers § 451.12 Application for approval by design type. (a) For approval of new containers by design type, each application must include the following: (1) Engineering drawings and plans...

  3. 49 CFR 451.12 - Application for approval by design type.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false Application for approval by design type. 451.12... Approval of New Containers § 451.12 Application for approval by design type. (a) For approval of new containers by design type, each application must include the following: (1) Engineering drawings and plans...

  4. 49 CFR 451.12 - Application for approval by design type.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 6 2011-10-01 2011-10-01 false Application for approval by design type. 451.12... Approval of New Containers § 451.12 Application for approval by design type. (a) For approval of new containers by design type, each application must include the following: (1) Engineering drawings and plans...

  5. Molecular gas in supernova local environments unveiled by EDGE

    NASA Astrophysics Data System (ADS)

    Galbany, L.; Mora, L.; González-Gaitán, S.; Bolatto, A.; Dannerbauer, H.; López-Sánchez, Á. R.; Maeda, K.; Pérez, S.; Pérez-Torres, M. A.; Sánchez, S. F.; Wong, T.; Badenes, C.; Blitz, L.; Marino, R. A.; Utomo, D.; Van de Ven, G.

    2017-06-01

    CO observations allow estimation of the gas content of molecular clouds, which trace the reservoir of cold gas fuelling star formation, as well as determination of extinction via H2 column density, N(H2). Here, we study millimetric and optical properties at 26 supernovae (SNe) locations of different types in a sample of 23 nearby galaxies, by combining molecular 12C16O (J = 1 → 0) resolved maps from the Extragalactic Database for Galaxy Evolution (EDGE) survey and optical Integral Field Spectroscopy (IFS) from the Calar Alto Legacy Integral Field Area (CALIFA) survey. We found an even clearer separation between type II and type Ibc SNe in terms of molecular gas than is found in the optical using Hα emission as a proxy for the current star formation (SF) rate, which reinforces the fact that SNe Ibc are more associated with SF environments. While AV at SN locations is similar for SNe II and SNe Ibc and higher than for SNe Ia, N(H2) is significantly higher for SNe Ibc than for SNe II and Ia. When compared with alternative extinction estimations made directly from SN photometry and spectroscopy, we find that our SNe Ibc also have redder colour excess, but showed standard Na I D absorption pseudo-equivalent widths (˜1 Å). In some cases, we find no extinction when IT is estimated from the environment but high amounts of extinction when measured from SN observations, which suggests that circumstellar material or dust sublimation may be playing a role. This work serves as a benchmark for future studies combining last-generation millimetre and optical IFS instruments to reveal the local environmental properties of extragalactic SNe.

  6. The RACE (Research and Development in Advanced Technologies for Europe) Program: A 1989 Update

    DTIC Science & Technology

    1989-12-15

    Definition TV (HDTV) Expcrimcntal Usage . A......a.d..r Dist special 1081 - Broadband User Network Interface (BUNI)..................... 4 1082 ...develop man/machine which will provide a traffic analyzer and generator. interfaces that are consistent across a wide range of ap-plications. 1082 ... 1082 are to provide usage reference models for the different types of e Define IBC quality of service rquiremnts by usage design issue. It deals with

  7. Mammary stem cell and macrophage markers are enriched in normal tissue adjacent to inflammatory breast cancer.

    PubMed

    Reddy, Jay P; Atkinson, Rachel L; Larson, Richard; Burks, Jared K; Smith, Daniel; Debeb, Bisrat G; Ruffell, Brian; Creighton, Chad J; Bambhroliya, Arvind; Reuben, James M; Van Laere, Steven J; Krishnamurthy, Savitri; Symmans, William F; Brewster, Abenaa M; Woodward, Wendy A

    2018-06-01

    We hypothesized that breast tissue not involved by tumor in inflammatory breast cancer (IBC) patients contains intrinsic differences, including increased mammary stem cells and macrophage infiltration, which may promote the IBC phenotype. Normal breast parenchyma ≥ 5 cm away from primary tumors was obtained from mastectomy specimens. This included an initial cohort of 8 IBC patients and 60 non-IBC patients followed by a validation cohort of 19 IBC patients and 25 non-IBC patients. Samples were immunostained for either CD44 + CD49f + CD133/2 + mammary stem cell markers or the CD68 macrophage marker and correlated with IBC status. Quantitation of positive cells was determined using inForm software from PerkinElmer. We also examined the association between IBC status and previously published tumorigenic stem cell and IBC tumor signatures in the validation cohort samples. 8 of 8 IBC samples expressed isolated CD44 + CD49f + CD133/2 + stem cell marked cells in the initial cohort as opposed to 0/60 non-IBC samples (p = 0.001). Similarly, the median number of CD44 + CD49f + CD133/2 + cells was significantly higher in the IBC validation cohort as opposed to the non-IBC validation cohort (25.7 vs. 14.2, p = 0.007). 7 of 8 IBC samples expressed CD68 + histologically confirmed macrophages in initial cohort as opposed to 12/48 non-IBC samples (p = 0.001). In the validation cohort, the median number of CD68 + cells in IBC was 3.7 versus 1.0 in the non-IBC cohort (p = 0.06). IBC normal tissue was positively associated with a tumorigenic stem cell signature (p = 0.02) and with a 79-gene IBC signature (p < 0.001). Normal tissue from IBC patients is enriched for both mammary stem cells and macrophages and has higher association with both a tumorigenic stem cell signature and IBC-specific tumor signature. Collectively, these data suggest that IBC normal tissue differs from non-IBC tissue. Whether these changes occur before the tumor develops or

  8. 14 CFR 21.97 - Approval of major changes in type design.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... necessary descriptive data for inclusion in the type design the other configurations of the same engine type... for approval of a major change in type design must— (1) Provide substantiating data and necessary descriptive data for inclusion in the type design; (2) Show that the changed product complies with the...

  9. Long-Term Outcome of Inflammatory Breast Cancer Compared to Non-Inflammatory Breast Cancer in the Setting of High-Dose Chemotherapy with Autologous Hematopoietic Cell Transplantation

    PubMed Central

    Cheng, Yee Chung; Shi, Yushu; Zhang, Mei-Jie; Brazauskas, Ruta; Hemmer, Michael T.; Bishop, Michael R.; Nieto, Yago; Stadtmauer, Edward; Ayash, Lois; Gale, Robert Peter; Lazarus, Hillard; Holmberg, Leona; Lill, Michael; Olsson, Richard F.; Wirk, Baldeep Mona; Arora, Mukta; Hari, Parameswaran; Ueno, Naoto

    2017-01-01

    Introduction: Inflammatory breast cancer (IBC) is a rare aggressive form of breast cancer. It is well known that the long-term survival and progression-free survival of IBC are worse than that of non-IBC. We report the long term outcomes of patients with IBC and non-IBC who had undergone high-dose chemotherapy (HDC) with autologous hematopoietic cell transplantation (AHCT). Methods: All 3387 patients with IBC or non-IBC who underwent HDC with AHCT between1990-2002 and registered with CIBMTR were included in this analysis. Transplant-related mortality (TRM), disease relapse/progression, progression-free survival (PFS) and overall survival (OS) were compared between the two cohorts. Multivariate Cox regression model was used to determine the independent impact of stage on outcomes. Results: 527 patients with IBC and 2,860 patients with non-IBC were included; the median age at transplantation (47 vs 46 years old) and median follow-up period in the 2 groups (167 vs 168 months) were similar. The most common conditioning regimen was cyclophosphamide and carboplatin based in both groups (54% in IBC and 50% in non-IBC). AHCT was well tolerated in both groups. TRM was similar in both groups (one year TRM was 2% for IBC and 3% for non-IBC, p=0.16). The most common cause of death was disease progression or relapse (81% in IBC and 75% in non-IBC). The median survival for both IBC and non-IBC was the same at 40 months. The PFS at 10 years was 27% (95% CI: 23-31%) for IBC and 24% (95% CI: 22-26%) for non-IBC (p=0.21), and the OS at 10 years was 31% (95% CI: 27-35%) for IBC and 28% (95% CI: 26-30%) for non-IBC (p=0.16). In univariate analysis, patients with stage III IBC and no active diseases at transplantation had lower PFS and OS than that in non-IBC. In multivariate analysis, controlling for age, disease status at AHCT, hormonal receptor status, time from diagnosis to AHCT, and performance status at AHCT, patients with stage III IBC had higher mortality (HR 1.16, 95% CI: 1

  10. 14 CFR 21.95 - Approval of minor changes in type design.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Approval of minor changes in type design... TRANSPORTATION AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Changes to Type Certificates § 21.95 Approval of minor changes in type design. Minor changes in a type design may be approved under a method...

  11. 14 CFR 21.95 - Approval of minor changes in type design.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Approval of minor changes in type design... TRANSPORTATION AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Changes to Type Certificates § 21.95 Approval of minor changes in type design. Minor changes in a type design may be approved under a method...

  12. 14 CFR 21.95 - Approval of minor changes in type design.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Approval of minor changes in type design... TRANSPORTATION AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Changes to Type Certificates § 21.95 Approval of minor changes in type design. Minor changes in a type design may be approved under a method...

  13. 14 CFR 21.95 - Approval of minor changes in type design.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Approval of minor changes in type design... TRANSPORTATION AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Changes to Type Certificates § 21.95 Approval of minor changes in type design. Minor changes in a type design may be approved under a method...

  14. 14 CFR 21.95 - Approval of minor changes in type design.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Approval of minor changes in type design... TRANSPORTATION AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Changes to Type Certificates § 21.95 Approval of minor changes in type design. Minor changes in a type design may be approved under a method...

  15. Combined wind turbine fatigue and ultimate load reduction by individual blade control

    NASA Astrophysics Data System (ADS)

    Han, Y.; Leithead, W. E.

    2014-06-01

    If each blade of the wind turbine has individual pitch actuator, there is possibility of employing the pitch system to mitigate structural loads through advanced control methods. Previously, considerable reduction of blade lifetime equivalent fatigue loads has been achieved by Individual Blade Control (IBC) and in addition, it has also been shown the potential in blade ultimate loads reduction. However, both fatigue and ultimate loads impact on the design and life of wind turbine blades. In this paper, the design and application of IBC that concurrently reduce both blade fatigue and ultimate loads is investigated. The contributions of blade load spectral components, which are 1P, 2P and edgewise mode from blade in-plane and/or out-of-plane bending moments, are firstly explored. Four different control options for reducing various combinations of these load components are compared. In response to the different spectral peaks of both fatigue and ultimate loads, the controller has been designed so that it can act on different frequency components which vary with wind speed. The performance of the IBC controller on fatigue and ultimate load reduction is assessed by simulating a 5MW exemplar wind turbine. Simulation results show that with a proper selection of controlling inputs at different wind speed, the use of a single combined IBC can achieve satisfactory reduction on both fatigue and ultimate loads.

  16. 14 CFR 21.97 - Approval of major changes in type design.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    .... (a) An applicant for approval of a major change in type design must— (1) Provide substantiating data and necessary descriptive data for inclusion in the type design; (2) Show that the changed product... the necessary descriptive data for inclusion in the type design the other configurations of the same...

  17. 14 CFR 21.97 - Approval of major changes in type design.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... must submit substantiating data and necessary descriptive data for inclusion in the type design. (b... major change in type design must— (1) Provide substantiating data and necessary descriptive data for... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Approval of major changes in type design...

  18. Population Dynamics and Niche Distribution of Uropathogenic Escherichia coli during Acute and Chronic Urinary Tract Infection ▿ †

    PubMed Central

    Schwartz, Drew J.; Chen, Swaine L.; Hultgren, Scott J.; Seed, Patrick C.

    2011-01-01

    Urinary tract infections (UTIs) have complex dynamics, with uropathogenic Escherichia coli (UPEC), the major causative agent, capable of colonization from the urethra to the kidneys in both extracellular and intracellular niches while also producing chronic persistent infections and frequent recurrent disease. In mouse and human bladders, UPEC invades the superficial epithelium, and some bacteria enter the cytoplasm to rapidly replicate into intracellular bacterial communities (IBCs) comprised of ∼104 bacteria each. Through IBC formation, UPEC expands in numbers while subverting aspects of the innate immune response. Within 12 h of murine bladder infection, half of the bacteria are intracellular, with 3 to 700 IBCs formed. Using mixed infections with green fluorescent protein (GFP) and wild-type (WT) UPEC, we discovered that each IBC is clonally derived from a single bacterium. Genetically tagged UPEC and a multiplex PCR assay were employed to investigate the distribution of UPEC throughout urinary tract niches over time. In the first 24 h postinfection (hpi), the fraction of tags dramatically decreased in the bladder and kidney, while the number of CFU increased. The percentage of tags detected at 6 hpi correlated to the number of IBCs produced, which closely matched a calculated multinomial distribution based on IBC clonality. The fraction of tags remaining thereafter depended on UTI outcome, which ranged from resolution of infection with or without quiescent intracellular reservoirs (QIRs) to the development of chronic cystitis as defined by persistent bacteriuria. Significantly more tags remained in mice that developed chronic cystitis, arguing that during the acute stages of infection, a higher number of IBCs precedes chronic cystitis than precedes QIR formation. PMID:21807904

  19. Reoperation Rates in Ductal Carcinoma In Situ vs Invasive Breast Cancer After Wire-Guided Breast-Conserving Surgery.

    PubMed

    Langhans, Linnea; Jensen, Maj-Britt; Talman, Maj-Lis M; Vejborg, Ilse; Kroman, Niels; Tvedskov, Tove F

    2017-04-01

    New techniques for preoperative localization of nonpalpable breast lesions may decrease the reoperation rate in breast-conserving surgery (BCS) compared with rates after surgery with the standard wire-guided localization. However, a valid reoperation rate for this procedure needs to be established for comparison, as previous studies on this procedure include a variety of malignant and benign breast lesions. To determine the reoperation rate after wire-guided BCS in patients with histologically verified nonpalpable invasive breast cancer (IBC) or ductal carcinoma in situ (DCIS) and to examine whether the risk of reoperation is associated with DCIS or histologic type of the IBC. This nationwide study including women with histologically verified IBC or DCIS having wire-guided BCS performed between January 1, 2010, and December 31, 2013, used data from the Danish National Patient Registry that were cross-checked with the Danish Breast Cancer Group database and the Danish Pathology Register. Reoperation rate after wire-guided BCS in patients with IBC or DCIS. Wire-guided BCS was performed in 4118 women (mean [SD] age, 60.9 [8.7] years). A total of 725 patients (17.6%) underwent a reoperation: 593 were reexcisions (14.4%) and 132 were mastectomies (3.2%). Significantly more patients with DCIS (271 of 727 [37.3%]) than with IBC (454 of 3391 [13.4%]) underwent a reoperation (adjusted odds ratio, 3.82; 95% CI, 3.19-4.58; P < .001). After the first reexcision, positive margins were still present in 97 patients (16.4%). The risk of repeated positive margins was significantly higher in patients with DCIS vs those with IBC (unadjusted odds ratio, 2.21; 95% CI, 1.42-3.43; P < .001). The risk of reoperation was significantly increased in patients with lobular carcinoma vs those with ductal carcinoma (adjusted odds ratio, 1.44; 95% CI 1.06-1.95; P = .02). A total of 202 patients (4.9%) had a subsequent completion mastectomy, but no difference was found in the type of

  20. Clinical characteristics and outcome of bone-only metastasis in inflammatory and noninflammatory breast cancers.

    PubMed

    Kai, Megumi; Kogawa, Takahiro; Liu, Diane D; Fouad, Tamer M; Kai, Kazuharu; Niikura, Naoki; Hsu, Limin; Willey, Jie S; Theriault, Richard L; Valero, Vicente; Ueno, Naoto T

    2015-02-01

    Inflammatory breast cancer is a rare and aggressive presentation of breast cancer. Bone is a common metastatic site in breast cancer, and bone-only metastatic disease is clinically considered to have a better prognosis than visceral metastasis. However, bone-only metastasis in IBC (bone-only IBC) has not been compared with bone-only metastasis in non-IBC (bone-only non-IBC) in terms of clinical features and outcome. Because of the intrinsically aggressive nature of IBC, we hypothesized that bone-only IBC has a poorer prognosis than does bone-only non-IBC. We retrospectively identified patients with stage III primary diagnosed breast cancer who, between January 1997 and December 2012, had a first recurrence located only in the bone. Among the 197 patients that we defined as a study cohort, 50 patients had IBC and 147 patients had non-IBC. Progression-free survival (PFS) and overall survival (OS) from the date of recurrence were estimated using the Kaplan-Meier method, and patient characteristic groups were compared using the log-rank test. OS did not differ significantly between the 2 groups (P = .2467), but a shorter PFS was seen in patients with bone-only IBC than in patients with bone-only non-IBC (P = .0357). Among patients with estrogen receptor (ER)-positive disease, a much shorter PFS was seen in bone-only IBC than in bone-only non-IBC (P = .0159). Bone-only IBC has a poorer prognosis than does bone-only non-IBC, particularly in those with ER-positive tumors. We might need to consider more aggressive intervention (e.g., chemotherapy) for IBC patients with ER-positive bone-only metastatic disease. Copyright © 2015 Elsevier Inc. All rights reserved.

  1. Overall survival differences between patients with inflammatory and noninflammatory breast cancer presenting with distant metastasis at diagnosis.

    PubMed

    Fouad, Tamer M; Kogawa, Takahiro; Liu, Diane D; Shen, Yu; Masuda, Hiroko; El-Zein, Randa; Woodward, Wendy A; Chavez-MacGregor, Mariana; Alvarez, Ricardo H; Arun, Banu; Lucci, Anthony; Krishnamurthy, Savitri; Babiera, Gildy; Buchholz, Thomas A; Valero, Vicente; Ueno, Naoto T

    2015-07-01

    Inflammatory breast cancer (IBC) is a rare and aggressive disease. Previous studies have shown that among patients with stage III breast cancer, IBC is associated with a worse prognosis than noninflammatory breast cancer (non-IBC). Whether this difference holds true among patients with stage IV breast cancer has not been studied. We tested the hypothesis that overall survival (OS) is worse in patients with IBC than in those with non-IBC among patients with distant metastasis at diagnosis (stage IV disease). We reviewed the records of 1504 consecutive patients with stage IV breast cancer (IBC: 206; non-IBC: 1298) treated at our institution from 1987 through 2012. Survival curves for IBC and non-IBC subcohorts were compared. The Cox proportional hazards model was used to determine predictors of OS. The median follow-up period was 4.7 years. IBC was associated with shorter median OS time than non-IBC (2.27 vs. 3.40 years; P = 0.0128, log-rank test). In a multicovariate Cox model that included 1389 patients, the diagnosis of IBC was a significant independent predictor of worse OS (hazard ratio = 1.431, P = 0.0011). Other significant predictors of worse OS included Black (vs. White) ethnicity, younger age at diagnosis, negative HER2 status, and visceral (vs. nonvisceral) site of metastasis. IBC is associated with shorter OS than non-IBC in patients with distant metastasis at diagnosis. The prognostic impact of IBC should be taken into consideration among patients with stage IV breast cancer.

  2. Optimal hydraulic design of new-type shaft tubular pumping system

    NASA Astrophysics Data System (ADS)

    Zhu, H. G.; Zhang, R. T.; Zhou, J. R.

    2012-11-01

    Based on the characteristics of large flow rate, low-head, short annual operation time and high reliability of city flood-control pumping stations, a new-type shaft tubular pumping system featuring shaft suction box, siphon-type discharge passage with vacuum breaker as cutoff device was put forward, which possesses such advantages as simpler structure, reliable cutoff and higher energy performance. According to the design parameters of a city flood control pumping station, a numerical computation model was set up including shaft-type suction box, siphon-type discharge passage, pump impeller and guide vanes. By using commercial CFD software Fluent, RNG κ-epsilon turbulence model was adopted to close the three-dimensional time-averaged incompressible N-S equations. After completing optimal hydraulic design of shaft-type suction box, and keeping the parameters of total length, maximum width and outlet section unchanged, siphon-type discharge passages of three hump locations and three hump heights were designed and numerical analysis on the 9 hydraulic design schemes of pumping system were proceeded. The computational results show that the changing of hump locations and hump heights directly affects the internal flow patterns of discharge passages and hydraulic performances of the system, and when hump is located 3.66D from the inlet section and hump height is about 0.65D (D is the diameter of pump impeller), the new-type shaft tubular pumping system achieves better energy performances. A pumping system model test of the optimal designed scheme was carried out. The result shows that the highest pumping system efficiency reaches 75.96%, and when at design head of 1.15m the flow rate and system efficiency were 0.304m3/s and 63.10%, respectively. Thus, the validity of optimal design method was verified by the model test, and a solid foundation was laid for the application and extension of the new-type shaft tubular pumping system.

  3. Robustness of controllers designed using Galerkin type approximations

    NASA Technical Reports Server (NTRS)

    Morris, K. A.

    1990-01-01

    One of the difficulties in designing controllers for infinite-dimensional systems arises from attempting to calculate a state for the system. It is shown that Galerkin type approximations can be used to design controllers which will perform as designed when implemented on the original infinite-dimensional system. No assumptions, other than those typically employed in numerical analysis, are made on the approximating scheme.

  4. The effect of ilmenite viscosity on the dynamics and evolution of an overturned lunar cumulate mantle

    NASA Astrophysics Data System (ADS)

    Zhang, Nan; Dygert, Nick; Liang, Yan; Parmentier, E. M.

    2017-07-01

    Lunar cumulate mantle overturn and the subsequent upwelling of overturned mantle cumulates provide a potential framework for understanding the first-order thermochemical evolution of the Moon. Upwelling of ilmenite-bearing cumulates (IBCs) after the overturn has a dominant influence on the dynamics and long-term thermal evolution of the lunar mantle. An important parameter determining the stability and convective behavior of the IBC is its viscosity, which was recently constrained through rock deformation experiments. To examine the effect of IBC viscosity on the upwelling of overturned lunar cumulate mantle, here we conduct three-dimensional mantle convection models with an evolving core superposed by an IBC-rich layer, which resulted from mantle overturn after magma ocean solidification. Our modeling shows that a reduction of mantle viscosity by 1 order of magnitude, due to the presence of ilmenite, can dramatically change convective planform and long-term lunar mantle evolution. Our model results suggest a relatively stable partially molten IBC layer that has surrounded the lunar core to the present day.type="synopsis">type</span>="main">Plain Language SummaryThe Moon's mantle is locally ilmenite rich. Previous models exploring the convective evolution of the lunar mantle did not consider the effects of ilmenite viscosity. Recent rock deformation experiments demonstrate that Fe-Ti oxide (ilmenite) is a low viscosity phase compared to olivine and other silicate minerals. Our modeling shows that ilmenite changes the lunar mantle plume process. An ilmenite-rich layer around the lunar core would be highly stable throughout geologic time, consistent with a partially molten, low viscosity layer around the core inferred from seismic attenuation and tidal dissipation.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=Layout+AND+Design&id=EJ889544','ERIC'); return false;" href="https://eric.ed.gov/?q=Layout+AND+Design&id=EJ889544"><span>European <span class="hlt">Design</span> <span class="hlt">Types</span> for 21st Century Schools: An Overview</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Rigolon, Alessandro</p> <p>2010-01-01</p> <p>This article presents a critical overview of European school building <span class="hlt">design</span> <span class="hlt">types</span>, based on an analysis of morphologies and spatial layouts. The different <span class="hlt">design</span> <span class="hlt">types</span> are evaluated in function of specific didactic and social needs. (Contains 1 figure, 18 footnotes, a bibliography and 2 online resources.)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title14-vol1/pdf/CFR-2014-title14-vol1-sec21-97.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title14-vol1/pdf/CFR-2014-title14-vol1-sec21-97.pdf"><span>14 CFR 21.97 - Approval of major changes in <span class="hlt">type</span> <span class="hlt">design</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-01-01</p> <p>... must— (1) Provide substantiating data and necessary descriptive data for inclusion in the <span class="hlt">type</span> <span class="hlt">design</span>... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Approval of major changes in <span class="hlt">type</span> <span class="hlt">design</span>... TRANSPORTATION AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Changes to <span class="hlt">Type</span> Certificates § 21.97...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20100026825','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20100026825"><span>Development and Operation of an Automatic Rotor Trim Control System for the UH-60 Individual Blade Control Wind Tunnel Test</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Theodore, Colin R.; Tischler, Mark B.</p> <p>2010-01-01</p> <p>An automatic rotor trim control system was developed and successfully used during a wind tunnel test of a full-scale UH-60 rotor system with Individual Blade Control (<span class="hlt">IBC</span>) actuators. The trim control system allowed rotor trim to be set more quickly, precisely and repeatably than in previous wind tunnel tests. This control system also allowed the rotor trim state to be maintained during transients and drift in wind tunnel flow, and through changes in <span class="hlt">IBC</span> actuation. The ability to maintain a consistent rotor trim state was key to quickly and accurately evaluating the effect of <span class="hlt">IBC</span> on rotor performance, vibration, noise and loads. This paper presents details of the <span class="hlt">design</span> and implementation of the trim control system including the rotor system hardware, trim control requirements, and trim control hardware and software implementation. Results are presented showing the effect of <span class="hlt">IBC</span> on rotor trim and dynamic response, a validation of the rotor dynamic simulation used to calculate the initial control gains and tuning of the control system, and the overall performance of the trim control system during the wind tunnel test.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title14-vol1/pdf/CFR-2012-title14-vol1-sec21-97.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title14-vol1/pdf/CFR-2012-title14-vol1-sec21-97.pdf"><span>14 CFR 21.97 - Approval of major changes in <span class="hlt">type</span> <span class="hlt">design</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-01-01</p> <p>... must— (1) Provide substantiating data and necessary descriptive data for inclusion in the <span class="hlt">type</span> <span class="hlt">design</span>... is made unless the applicant identifies in the necessary descriptive data for inclusion in the <span class="hlt">type</span>... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Approval of major changes in <span class="hlt">type</span> <span class="hlt">design</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22661315-searching-expelled-hydrogen-envelope-type-supernovae-via-late-time-emission','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22661315-searching-expelled-hydrogen-envelope-type-supernovae-via-late-time-emission"><span>Searching for the Expelled Hydrogen Envelope in <span class="hlt">Type</span> I Supernovae via Late-Time H α Emission</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Vinko, J.; Silverman, J. M.; Wheeler, J. C.</p> <p>2017-03-01</p> <p>We report the first results from our long-term observational survey aimed at discovering late-time interaction between the ejecta of hydrogen-poor <span class="hlt">Type</span> I supernovae (SNe I) and the hydrogen-rich envelope expelled from the progenitor star several decades/centuries before explosion. The expelled envelope, moving with a velocity of ∼10–100 km s{sup −1}, is expected to be caught up by the fast-moving SN ejecta several years/decades after explosion, depending on the history of the mass-loss process acting in the progenitor star prior to explosion. The collision between the SN ejecta and the circumstellar envelope results in net emission in the Balmer lines, especiallymore » H α . We look for signs of late-time H α emission in older SNe Ia/<span class="hlt">Ibc</span>/IIb with hydrogen-poor ejecta via narrowband imaging. Continuum-subtracted H α emission has been detected for 13 point sources: 9 SN <span class="hlt">Ibc</span>, 1 SN IIb, and 3 SN Ia events. Thirty-eight SN sites were observed on at least two epochs, from which three objects (SN 1985F, SN 2005kl, and SN 2012fh) showed significant temporal variation in the strength of their H α emission in our Direct Imaging Auxiliary Functions Instrument (DIAFI) data. This suggests that the variable emission is probably not due to nearby H ii regions unassociated with the SN and hence is an important additional hint that ejecta–circumstellar medium interaction may take place in these systems. Moreover, we successfully detected the late-time H α emission from the <span class="hlt">Type</span> Ib SN 2014C, which was recently discovered as a strongly interacting SN in various (radio, infrared, optical, and X-ray) bands.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27791177','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27791177"><span>Towards a transcriptome-based theranostic platform for unfavorable breast cancer phenotypes.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Dobroff, Andrey S; D'Angelo, Sara; Eckhardt, Bedrich L; Ferrara, Fortunato; Staquicini, Daniela I; Cardó-Vila, Marina; Staquicini, Fernanda I; Nunes, Diana N; Kim, Kisu; Driessen, Wouter H P; Hajitou, Amin; Lomo, Lesley C; Barry, Marc; Krishnamurthy, Savitri; Sahin, Aysegul; Woodward, Wendy A; Prossnitz, Eric R; Anderson, Robin L; Dias-Neto, Emmanuel; Brown-Glaberman, Ursa A; Royce, Melanie E; Ueno, Naoto T; Cristofanilli, Massimo; Hortobagyi, Gabriel N; Marchiò, Serena; Gelovani, Juri G; Sidman, Richard L; Arap, Wadih; Pasqualini, Renata</p> <p>2016-10-24</p> <p>Inflammatory breast carcinoma (<span class="hlt">IBC</span>) is one of the most lethal forms of human breast cancer, and effective treatment for <span class="hlt">IBC</span> is an unmet clinical need in contemporary oncology. Tumor-targeted theranostic approaches are emerging in precision medicine, but only a few specific biomarkers are available. Here we report up-regulation of the 78-kDa glucose-regulated protein (GRP78) in two independent discovery and validation sets of specimens derived from <span class="hlt">IBC</span> patients, suggesting translational promise for clinical applications. We show that a GRP78-binding motif displayed on either bacteriophage or adeno-associated virus/phage (AAVP) particles or loop-grafted onto a human antibody fragment specifically targets orthotopic <span class="hlt">IBC</span> and other aggressive breast cancer models in vivo. To evaluate the theranostic value, we used GRP78-targeting AAVP particles to deliver the human Herpes simplex virus thymidine kinase <span class="hlt">type</span>-1 (HSVtk) transgene, obtaining simultaneous in vivo diagnosis through PET imaging and tumor treatment by selective activation of the prodrug ganciclovir at tumor sites. Translation of this AAVP system is expected simultaneously to image, monitor, and treat the <span class="hlt">IBC</span> phenotype and possibly other aggressive (e.g., invasive and/or metastatic) subtypes of breast cancer, based on the inducible cell-surface expression of the stress-response chaperone GRP78, and possibily other cell-surface receptors in human tumors.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23701774','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23701774"><span>Does an isolated benign choledochal stricture hide a PSC?</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>De Angelis, Paola; Tambucci, Renato; Romeo, Erminia; Rea, Francesca; Caloisi, Claudia; Caldaro, Tamara; di Abriola, Giovanni Federici; Foschia, Francesca; Torroni, Filippo; Monti, L; Dall'Oglio, Luigi</p> <p>2013-05-01</p> <p>Strictures of the extra-hepatic biliary tree are rare in children and have a benign non-traumatic inflammatory origin or are related to idiopathic fibrosing pancreatitis. Primary sclerosing cholangitis (PSC) can manifest as multiple biliary strictures or as a single dominant stricture. We describe the presentation, treatment, and outcome of six cases of isolated benign choledochal stricture (<span class="hlt">IBCS</span>). All patients underwent magnetic resonance cholangiography (MRC). Five patients underwent diagnostic and therapeutic ERCP, and 4 patients underwent intra-choledochal mini-probe EUS and biopsy. Colonoscopy was performed in suspected ulcerative colitis (UC). We report 6 patients (mean age at diagnosis: four males, 12.1 years; two females, 14.2 years) with <span class="hlt">IBCS</span>. Clinical onset included 3 cases of acute biliary pancreatitis and obstructive jaundice, one obstructive jaundice, one cholestasis, and one pancreatitis. At diagnosis, MRC confirmed <span class="hlt">IBCS</span> in all patients. Biliary sphincterotomy, stricture dilation, and stenting were performed in 4 patients. One child underwent hepaticojejunostomy for a <span class="hlt">type</span> I choledocal cyst. During follow-up (mean: 21 months; range: 1-3 years), all patients were asymptomatic. Four patients developed UC (three pancolitis, one descending colitis). One child developed PSC. <span class="hlt">IBCS</span> can be successfully treated by therapeutic ERCP. The occurrence of UC could suggest that <span class="hlt">IBCS</span> is a form of PSC. Copyright © 2013 Elsevier Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23733378','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23733378"><span>Detection of intracellular bacterial communities in a child with Escherichia coli recurrent urinary tract infections.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Robino, Luciana; Scavone, Paola; Araujo, Lucia; Algorta, Gabriela; Zunino, Pablo; Vignoli, Rafael</p> <p>2013-08-01</p> <p>The formation of intracellular bacterial communities (<span class="hlt">IBC</span>) has been proposed as a new pathogenic model for urinary tract infections. Scarce reports describe this phenomenon in humans. We describe the presence of <span class="hlt">IBC</span> in uroepithelial cells of a child with recurrent urinary infections. Urine specimen was collected from a child with Escherichia coli UTI and analyzed by light and confocal laser scanning microscopy (CLSM). The capability of this strain to produce intracellular infection in bladder tissue was confirmed in mice models. Escherichia coli phylogenetic group, presence of virulence factors genes, and its multiple locus sequence <span class="hlt">type</span> were determined. CLSM showed large collections of morphologically coccoid and rod bacteria in eukaryotic cells cytoplasm, even seemingly protruding from the cells. Escherichia coli EC7U, ST3626, harbored <span class="hlt">type</span> 1, P, and S/F1C fimbriae and K1 capsule genes. In this report, we confirm the presence of <span class="hlt">IBC</span> in children with UTI, as it has been described before in women. © 2013 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016PhDT........23B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016PhDT........23B"><span><span class="hlt">Design</span> and optimization of membrane-<span class="hlt">type</span> acoustic metamaterials</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Blevins, Matthew Grant</p> <p></p> <p>One of the most common problems in noise control is the attenuation of low frequency noise. Typical solutions require barriers with high density and/or thickness. Membrane-<span class="hlt">type</span> acoustic metamaterials are a novel <span class="hlt">type</span> of engineered material capable of high low-frequency transmission loss despite their small thickness and light weight. These materials are ideally suited to applications with strict size and weight limitations such as aircraft, automobiles, and buildings. The transmission loss profile can be manipulated by changing the micro-level substructure, stacking multiple unit cells, or by creating multi-celled arrays. To date, analysis has focused primarily on experimental studies in plane-wave tubes and numerical modeling using finite element methods. These methods are inefficient when used for applications that require iterative changes to the structure of the material. To facilitate <span class="hlt">design</span> and optimization of membrane-<span class="hlt">type</span> acoustic metamaterials, computationally efficient dynamic models based on the impedance-mobility approach are proposed. Models of a single unit cell in a waveguide and in a baffle, a double layer of unit cells in a waveguide, and an array of unit cells in a baffle are studied. The accuracy of the models and the validity of assumptions used are verified using a finite element method. The remarkable computational efficiency of the impedance-mobility models compared to finite element methods enables implementation in <span class="hlt">design</span> tools based on a graphical user interface and in optimization schemes. Genetic algorithms are used to optimize the unit cell <span class="hlt">design</span> for a variety of noise reduction goals, including maximizing transmission loss for broadband, narrow-band, and tonal noise sources. The tools for <span class="hlt">design</span> and optimization created in this work will enable rapid implementation of membrane-<span class="hlt">type</span> acoustic metamaterials to solve real-world noise control problems.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018ATel11163....1B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018ATel11163....1B"><span>Spectroscopic classification of ASASSN-17rl as <span class="hlt">type</span> <span class="hlt">Ib/c</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Bose, S.; Chen, P.; Dong, Subo; Bersier, David; Prieto, J. L.</p> <p>2018-01-01</p> <p>We report optical spectroscopic observations of supernova candidate ASASSN-17rl / 2017jea (ATel #11103) done on UT 2017-12-28.47 with DBSP mounted on the Hale 5m telescope at Palomar Observatory and on 2018-01-11.92 with SPRAT mounted on the 2m Liverpool Telescope.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=DNA+AND+formation&pg=3&id=EJ309066','ERIC'); return false;" href="https://eric.ed.gov/?q=DNA+AND+formation&pg=3&id=EJ309066"><span>Institutional Biosafety Committees and the Inadequacies of Risk Regulation.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Bereano, Philip L.</p> <p>1984-01-01</p> <p>Discusses institutional biosafety committees (<span class="hlt">IBC</span>) which provide quasi-independent reviews of recombinant DNA work done at an institution. Considers the nature of <span class="hlt">IBC</span> operation, the National Institutes of Health "Guidelines for Recombinant DNA Research," the composition of <span class="hlt">IBCs</span>, the intellectual content of <span class="hlt">IBC</span> deliberations, and issues…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title49-vol3/pdf/CFR-2013-title49-vol3-sec178-815.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title49-vol3/pdf/CFR-2013-title49-vol3-sec178-815.pdf"><span>49 CFR 178.815 - Stacking test.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-10-01</p> <p>... deformation, which renders the <span class="hlt">IBC</span> unsafe for transportation, and no loss of contents. (2) For fiberboard and wooden <span class="hlt">IBCs</span>, there may be no loss of contents and no permanent deformation, which renders the whole <span class="hlt">IBC</span>..., which renders the <span class="hlt">IBC</span> unsafe for transportation, and no loss of contents. (4) For the dynamic...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title49-vol3/pdf/CFR-2011-title49-vol3-sec178-815.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title49-vol3/pdf/CFR-2011-title49-vol3-sec178-815.pdf"><span>49 CFR 178.815 - Stacking test.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-10-01</p> <p>... deformation, which renders the <span class="hlt">IBC</span> unsafe for transportation, and no loss of contents. (2) For fiberboard and wooden <span class="hlt">IBCs</span>, there may be no loss of contents and no permanent deformation, which renders the whole <span class="hlt">IBC</span>..., which renders the <span class="hlt">IBC</span> unsafe for transportation, and no loss of contents. (4) For the dynamic...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title49-vol3/pdf/CFR-2012-title49-vol3-sec178-815.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title49-vol3/pdf/CFR-2012-title49-vol3-sec178-815.pdf"><span>49 CFR 178.815 - Stacking test.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-10-01</p> <p>... deformation, which renders the <span class="hlt">IBC</span> unsafe for transportation, and no loss of contents. (2) For fiberboard and wooden <span class="hlt">IBCs</span>, there may be no loss of contents and no permanent deformation, which renders the whole <span class="hlt">IBC</span>..., which renders the <span class="hlt">IBC</span> unsafe for transportation, and no loss of contents. (4) For the dynamic...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title49-vol3/pdf/CFR-2014-title49-vol3-sec178-815.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title49-vol3/pdf/CFR-2014-title49-vol3-sec178-815.pdf"><span>49 CFR 178.815 - Stacking test.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-10-01</p> <p>... deformation, which renders the <span class="hlt">IBC</span> unsafe for transportation, and no loss of contents. (2) For fiberboard and wooden <span class="hlt">IBCs</span>, there may be no loss of contents and no permanent deformation, which renders the whole <span class="hlt">IBC</span>..., which renders the <span class="hlt">IBC</span> unsafe for transportation, and no loss of contents. (4) For the dynamic...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27036361','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27036361"><span>Predictive Factors of the Survival of Women With Invasive Breast Cancer in French Guiana: The Burden of Health Inequalities.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Roué, Tristan; Labbé, Sylvain; Belliardo, Sophie; Plenet, Juliette; Douine, Maylis; Nacher, Mathieu</p> <p>2016-08-01</p> <p>The prognosis of patients with breast cancer in French Guiana is worse than in France, with 23 deaths per 100 incident cases versus 17 per 100 in metropolitan France. This study aimed to compare the relative survival of patients with invasive breast cancer (<span class="hlt">IBC</span>) between women from French Guiana and metropolitan France and to determine risk factors influencing breast cancer survival in French Guiana. Data were collected from the Cancer Registry of French Guiana. We compared the relative survival of women with <span class="hlt">IBC</span> between French Guiana and metropolitan France. We used the Cox proportional hazard regression to evaluate the effect of prognostic factors on cancer-specific mortality in French Guiana. We included all 269 cases of <span class="hlt">IBC</span> in women diagnosed in French Guiana between 2003 and 2009. The overall 5-year relative survival rate of patients with <span class="hlt">IBC</span> was 79% in French Guiana and 86% in metropolitan France. The place of birth (foreign country vs. French territory), the tumor stage at the time of diagnosis, the mode of diagnosis (symptoms vs. screening), the presence of hormone receptors in the tumor, and the histologic <span class="hlt">type</span> were the variables associated with survival differences. None of the other study variables were significantly associated with prognosis. Access to care for migrants is challenging, which leads to health inequalities. Early detection through prevention programs is crucial to increase <span class="hlt">IBC</span> survival, notably for foreign-born patients. Copyright © 2016 Elsevier Inc. All rights reserved.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li class="active"><span>8</span></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_8 --> <div id="page_9" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li class="active"><span>9</span></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="161"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5004075','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5004075"><span>The proteome signature of the inflammatory breast cancer plasma membrane identifies novel molecular markers of disease</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Suárez-Arroyo, Ivette J; Feliz-Mosquea, Yismeilin R; Pérez-Laspiur, Juliana; Arju, Rezina; Giashuddin, Shah; Maldonado-Martínez, Gerónimo; Cubano, Luis A; Schneider, Robert J; Martínez-Montemayor, Michelle M</p> <p>2016-01-01</p> <p>Inflammatory Breast Cancer (<span class="hlt">IBC</span>) is the most lethal form of breast cancer with a 35% 5-year survival rate. The accurate and early diagnosis of <span class="hlt">IBC</span> and the development of targeted therapy against this deadly disease remain a great medical challenge. Plasma membrane proteins (PMPs) such as E-cadherin and EGFR, play an important role in the progression of <span class="hlt">IBC</span>. Because the critical role of PMPs in the oncogenic processes they are the perfect candidates as molecular markers and targets for cancer therapies. In the present study, Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC) followed by mass spectrometry analysis was used to compare the relative expression levels of membrane proteins (MP) between non-cancerous mammary epithelial and <span class="hlt">IBC</span> cells, MCF-10A and SUM-149, respectively. Six of the identified PMPs were validated by immunoblotting using the membrane fractions of non-<span class="hlt">IBC</span> and <span class="hlt">IBC</span> cell lines, compared with MCF-10A cells. Immunohistochemical analysis using <span class="hlt">IBC</span>, invasive ductal carcinoma or normal mammary tissue samples was carried out to complete the validation method in nine of the PMPs. We identified and quantified 278 MPs, 76% of which classified as PMPs with 1.3-fold or higher change. We identified for the first time the overexpression of the novel plasminogen receptor, PLGRKT in <span class="hlt">IBC</span> and of the carrier protein, SCAMP3. Furthermore, we describe the positive relationship between L1CAM expression and metastasis in <span class="hlt">IBC</span> patients and the role of SCAMP3 as a tumor-related protein. Overall, the membrane proteomic signature of <span class="hlt">IBC</span> reflects a global change in cellular organization and suggests additional strategies for cancer progression. Together, this study provides insight into the specialized <span class="hlt">IBC</span> plasma membrane proteome with the potential to identify a number of novel therapeutic targets for <span class="hlt">IBC</span>. PMID:27648361</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2140087','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2140087"><span>Detection of Intracellular Bacterial Communities in Human Urinary Tract Infection</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Rosen, David A; Hooton, Thomas M; Stamm, Walter E; Humphrey, Peter A; Hultgren, Scott J</p> <p>2007-01-01</p> <p>Background Urinary tract infections (UTIs) are one of the most common bacterial infections and are predominantly caused by uropathogenic Escherichia coli (UPEC). While UTIs are typically considered extracellular infections, it has been recently demonstrated that UPEC bind to, invade, and replicate within the murine bladder urothelium to form intracellular bacterial communities (<span class="hlt">IBCs</span>). These <span class="hlt">IBCs</span> dissociate and bacteria flux out of bladder facet cells, some with filamentous morphology, and ultimately establish quiescent intracellular reservoirs that can seed recurrent infection. This <span class="hlt">IBC</span> pathogenic cycle has not yet been investigated in humans. In this study we sought to determine whether evidence of an <span class="hlt">IBC</span> pathway could be found in urine specimens from women with acute UTI. Methods and Findings We collected midstream, clean-catch urine specimens from 80 young healthy women with acute uncomplicated cystitis and 20 asymptomatic women with a history of UTI. Investigators were blinded to culture results and clinical history. Samples were analyzed by light microscopy, immunofluorescence, and electron microscopy for evidence of exfoliated <span class="hlt">IBCs</span> and filamentous bacteria. Evidence of <span class="hlt">IBCs</span> was found in 14 of 80 (18%) urines from women with UTI. Filamentous bacteria were found in 33 of 80 (41%) urines from women with UTI. None of the 20 urines from the asymptomatic comparative group showed evidence of <span class="hlt">IBCs</span> or filaments. Filamentous bacteria were present in all 14 of the urines with <span class="hlt">IBCs</span> compared to 19 (29%) of 66 samples with no evidence of <span class="hlt">IBCs</span> (p < 0.001). Of 65 urines from patients with E. coli infections, 14 (22%) had evidence of <span class="hlt">IBCs</span> and 29 (45%) had filamentous bacteria, while none of the gram-positive infections had <span class="hlt">IBCs</span> or filamentous bacteria. Conclusions The presence of exfoliated <span class="hlt">IBCs</span> and filamentous bacteria in the urines of women with acute cystitis suggests that the <span class="hlt">IBC</span> pathogenic pathway characterized in the murine model may occur in humans. The findings</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27706216','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27706216"><span>Clinical and Economic Impact of a Digital, Remotely-Delivered Intensive Behavioral Counseling Program on Medicare Beneficiaries at Risk for Diabetes and Cardiovascular Disease.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Chen, Fang; Su, Wenqing; Becker, Shawn H; Payne, Mike; Castro Sweet, Cynthia M; Peters, Anne L; Dall, Timothy M</p> <p>2016-01-01</p> <p><span class="hlt">Type</span> 2 diabetes and cardiovascular disease impose substantial clinical and economic burdens for seniors (age 65 and above) and the Medicare program. Intensive Behavioral Counseling (<span class="hlt">IBC</span>) interventions like the National Diabetes Prevention Program (NDPP), have demonstrated effectiveness in reducing excess body weight and lowering or delaying morbidity onset. This paper estimated the potential health implications and medical savings of a digital version of <span class="hlt">IBC</span> modeled after the NDPP. Participants in this digital <span class="hlt">IBC</span> intervention, the Omada program, include 1,121 overweight or obese seniors with additional risk factors for diabetes or heart disease. Weight changes were objectively measured via participant use of a networked weight scale. Participants averaged 6.8% reduction in body weight within 26 weeks, and 89% of participants completed 9 or more of the 16 core phase lessons. We used a Markov-based microsimulation model to simulate the impact of weight loss on future health states and medical expenditures over 10 years. Cumulative per capita medical expenditure savings over 3, 5 and 10 years ranged from $1,720 to 1,770 (3 years), $3,840 to $4,240 (5 years) and $11,550 to $14,200 (10 years). The range reflects assumptions of weight re-gain similar to that seen in the DPP clinical trial (lower bound) or minimal weight re-gain aligned with age-adjusted national averages (upper bound). The estimated net economic benefit after <span class="hlt">IBC</span> costs is $10,250 to $12,840 cumulative over 10 years. Simulation outcomes suggest reduced incidence of diabetes by 27-41% for participants with prediabetes, and stroke by approximately 15% over 5 years. A digital, remotely-delivered <span class="hlt">IBC</span> program can help seniors at risk for diabetes and cardiovascular disease achieve significant weight loss, reduces risk for diabetes and cardiovascular disease, and achieve meaningful medical cost savings. These findings affirm recommendations for <span class="hlt">IBC</span> coverage by the U.S. Preventive Services Task Force.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25997452','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25997452"><span>Anti-HER2 CD4(+) T-helper <span class="hlt">type</span> 1 response is a novel immune correlate to pathologic response following neoadjuvant therapy in HER2-positive breast cancer.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Datta, Jashodeep; Berk, Erik; Xu, Shuwen; Fitzpatrick, Elizabeth; Rosemblit, Cinthia; Lowenfeld, Lea; Goodman, Noah; Lewis, David A; Zhang, Paul J; Fisher, Carla; Roses, Robert E; DeMichele, Angela; Czerniecki, Brian J</p> <p>2015-05-23</p> <p>A progressive loss of circulating anti-human epidermal growth factor receptor-2/neu (HER2) CD4(+) T-helper <span class="hlt">type</span> 1 (Th1) immune responses is observed in HER2(pos)-invasive breast cancer (<span class="hlt">IBC</span>) patients relative to healthy controls. Pathologic complete response (pCR) following neoadjuvant trastuzumab and chemotherapy (T + C) is associated with decreased recurrence and improved prognosis. We examined differences in anti-HER2 Th1 responses between pCR and non-pCR patients to identify modifiable immune correlates to pathologic response following neoadjuvant T + C. Anti-HER2 Th1 responses in 87 HER2(pos)-<span class="hlt">IBC</span> patients were examined using peripheral blood mononuclear cells pulsed with 6 HER2-derived class II peptides via IFN-γ ELISPOT. Th1 response metrics were anti-HER2 responsivity, repertoire (number of reactive peptides), and cumulative response across 6 peptides (spot-forming cells [SFC]/10(6) cells). Anti-HER2 Th1 responses of non-pCR patients (n = 4) receiving adjuvant HER2-pulsed <span class="hlt">type</span> 1-polarized dendritic cell (DC1) vaccination were analyzed pre- and post-immunization. Depressed anti-HER2 Th1 responses observed in treatment-naïve HER2(pos)-<span class="hlt">IBC</span> patients (n = 22) did not improve globally in T + C-treated HER2(pos)-<span class="hlt">IBC</span> patients (n = 65). Compared with adjuvant T + C receipt, neoadjuvant T + C - utilized in 61.5 % - was associated with higher anti-HER2 Th1 repertoire (p = 0.048). While pCR (n = 16) and non-pCR (n = 24) patients did not differ substantially in demographic/clinical characteristics, pCR patients demonstrated dramatically higher anti-HER2 Th1 responsivity (94 % vs. 33 %, p = 0.0002), repertoire (3.3 vs. 0.3 peptides, p < 0.0001), and cumulative response (148.2 vs. 22.4 SFC/10(6), p < 0.0001) versus non-pCR patients. After controlling for potential confounders, anti-HER2 Th1 responsivity remained independently associated with pathologic response (odds ratio 8.82, p = 0.016). This IFN-γ(+) immune disparity was mediated by anti-HER2 CD4(+)T</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=Qatar&pg=4&id=EJ1127983','ERIC'); return false;" href="https://eric.ed.gov/?q=Qatar&pg=4&id=EJ1127983"><span>Addressing Sustainable International Branch Campus Development through an Organizational Structure Lens: A Comparative Analysis of China, Qatar, and the United Arab Emirates</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Borgos, Jill</p> <p>2016-01-01</p> <p>The growth of international branch campuses (<span class="hlt">IBCs</span>) in China, Qatar, and the United Arab Emirates (UAE) accounts for a significant portion of the overall growth of <span class="hlt">IBCs</span> globally. Conversely the largest exporter of <span class="hlt">IBCs</span> globally is the United States, with several U.S. <span class="hlt">IBCs</span> located in each of these importing countries. With the intention of focusing…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title14-vol1/pdf/CFR-2010-title14-vol1-sec25-3.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title14-vol1/pdf/CFR-2010-title14-vol1-sec25-3.pdf"><span>14 CFR 25.3 - Special provisions for ETOPS <span class="hlt">type</span> <span class="hlt">design</span> approvals.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-01-01</p> <p>... 180 minutes, an applicant must comply with § 25.1535, except that it need not comply with the... ETOPS <span class="hlt">type</span> <span class="hlt">design</span> approval of an airplane beyond 180 minutes an applicant must comply with § 25.1535. (c) Airplanes with more than two engines. An applicant for ETOPS <span class="hlt">type</span> <span class="hlt">design</span> approval must comply with § 25.1535...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title14-vol1/pdf/CFR-2014-title14-vol1-sec25-3.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title14-vol1/pdf/CFR-2014-title14-vol1-sec25-3.pdf"><span>14 CFR 25.3 - Special provisions for ETOPS <span class="hlt">type</span> <span class="hlt">design</span> approvals.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-01-01</p> <p>... 180 minutes, an applicant must comply with § 25.1535, except that it need not comply with the... ETOPS <span class="hlt">type</span> <span class="hlt">design</span> approval of an airplane beyond 180 minutes an applicant must comply with § 25.1535. (c) Airplanes with more than two engines. An applicant for ETOPS <span class="hlt">type</span> <span class="hlt">design</span> approval must comply with § 25.1535...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title14-vol1/pdf/CFR-2011-title14-vol1-sec25-3.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title14-vol1/pdf/CFR-2011-title14-vol1-sec25-3.pdf"><span>14 CFR 25.3 - Special provisions for ETOPS <span class="hlt">type</span> <span class="hlt">design</span> approvals.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-01-01</p> <p>... 180 minutes, an applicant must comply with § 25.1535, except that it need not comply with the... ETOPS <span class="hlt">type</span> <span class="hlt">design</span> approval of an airplane beyond 180 minutes an applicant must comply with § 25.1535. (c) Airplanes with more than two engines. An applicant for ETOPS <span class="hlt">type</span> <span class="hlt">design</span> approval must comply with § 25.1535...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title14-vol1/pdf/CFR-2012-title14-vol1-sec25-3.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title14-vol1/pdf/CFR-2012-title14-vol1-sec25-3.pdf"><span>14 CFR 25.3 - Special provisions for ETOPS <span class="hlt">type</span> <span class="hlt">design</span> approvals.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-01-01</p> <p>... 180 minutes, an applicant must comply with § 25.1535, except that it need not comply with the... ETOPS <span class="hlt">type</span> <span class="hlt">design</span> approval of an airplane beyond 180 minutes an applicant must comply with § 25.1535. (c) Airplanes with more than two engines. An applicant for ETOPS <span class="hlt">type</span> <span class="hlt">design</span> approval must comply with § 25.1535...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title14-vol1/pdf/CFR-2013-title14-vol1-sec25-3.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title14-vol1/pdf/CFR-2013-title14-vol1-sec25-3.pdf"><span>14 CFR 25.3 - Special provisions for ETOPS <span class="hlt">type</span> <span class="hlt">design</span> approvals.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-01-01</p> <p>... 180 minutes, an applicant must comply with § 25.1535, except that it need not comply with the... ETOPS <span class="hlt">type</span> <span class="hlt">design</span> approval of an airplane beyond 180 minutes an applicant must comply with § 25.1535. (c) Airplanes with more than two engines. An applicant for ETOPS <span class="hlt">type</span> <span class="hlt">design</span> approval must comply with § 25.1535...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED014970.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED014970.pdf"><span>FORUM-<span class="hlt">TYPE</span> ROOMS--AN INNOVATION IN CLASSROOM <span class="hlt">DESIGN</span> AND UTILIZATION.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>HASKELL, BARRY S.</p> <p></p> <p>A FORUM-<span class="hlt">TYPE</span> ROOM IS ONE <span class="hlt">DESIGNED</span> TO PROVIDE EFFECTIVE, LARGE GROUP INSTRUCTION AT LOWER COST THAN IN REGULAR CLASSROOMS. INSTRUCTION BECOMES MORE EFFECTIVE THROUGH COORDINATED USE OF ALL <span class="hlt">TYPES</span> OF AUDIOVISUAL MEDIA, SUBPROFESSIONAL SUPPORTING STAFF, DETAILED PLANNING AND REHEARSAL, AND THE FACILITY ITSELF. A PROPOSED MODEL OF A FORUM-<span class="hlt">TYPE</span> ROOM…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20485429','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20485429"><span>A faint <span class="hlt">type</span> of supernova from a white dwarf with a helium-rich companion.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Perets, H B; Gal-Yam, A; Mazzali, P A; Arnett, D; Kagan, D; Filippenko, A V; Li, W; Arcavi, I; Cenko, S B; Fox, D B; Leonard, D C; Moon, D-S; Sand, D J; Soderberg, A M; Anderson, J P; James, P A; Foley, R J; Ganeshalingam, M; Ofek, E O; Bildsten, L; Nelemans, G; Shen, K J; Weinberg, N N; Metzger, B D; Piro, A L; Quataert, E; Kiewe, M; Poznanski, D</p> <p>2010-05-20</p> <p>Supernovae are thought to arise from two different physical processes. The cores of massive, short-lived stars undergo gravitational core collapse and typically eject a few solar masses during their explosion. These are thought to appear as <span class="hlt">type</span> <span class="hlt">Ib/c</span> and <span class="hlt">type</span> II supernovae, and are associated with young stellar populations. In contrast, the thermonuclear detonation of a carbon-oxygen white dwarf, whose mass approaches the Chandrasekhar limit, is thought to produce <span class="hlt">type</span> Ia supernovae. Such supernovae are observed in both young and old stellar environments. Here we report a faint <span class="hlt">type</span> Ib supernova, SN 2005E, in the halo of the nearby isolated galaxy, NGC 1032. The 'old' environment near the supernova location, and the very low derived ejected mass ( approximately 0.3 solar masses), argue strongly against a core-collapse origin. Spectroscopic observations and analysis reveal high ejecta velocities, dominated by helium-burning products, probably excluding this as a subluminous or a regular <span class="hlt">type</span> Ia supernova. We conclude that it arises from a low-mass, old progenitor, likely to have been a helium-accreting white dwarf in a binary. The ejecta contain more calcium than observed in other <span class="hlt">types</span> of supernovae and probably large amounts of radioactive (44)Ti.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4890726','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4890726"><span>Rational <span class="hlt">Design</span> of Peptide Vaccines Against Multiple <span class="hlt">Types</span> of Human Papillomavirus</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Dey, Sumanta; De, Antara; Nandy, Ashesh</p> <p>2016-01-01</p> <p>Human papillomavirus (HPV) occurs in many <span class="hlt">types</span>, some of which cause cervical, genital, and other cancers. While vaccination is available against the major cancer-causing HPV <span class="hlt">types</span>, many others are not covered by these preventive measures. Herein, we present a bioinformatics study for the <span class="hlt">designing</span> of multivalent peptide vaccines against multiple HPV <span class="hlt">types</span> as an alternative strategy to the virus-like particle vaccines being used now. Our technique of rational <span class="hlt">design</span> of peptide vaccines is expected to ensure stability of the vaccine against many cycles of mutational changes, elicit immune response, and negate autoimmune possibilities. Using the L1 capsid protein sequences, we identified several peptides for potential vaccine <span class="hlt">design</span> for HPV 16, 18, 33, 35, 45, and 11 <span class="hlt">types</span>. Although there are concerns about the epitope-binding affinities for the peptides identified in this process, the technique indicates possibilities of multivalent, adjuvanted, peptide vaccines against a wider range of HPV <span class="hlt">types</span>, and tailor-made different combinations of the peptides to address frequency variations of <span class="hlt">types</span> over different population groups as required for prophylaxis and at lower cost than are in use at the present time. PMID:27279731</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018E%26ES..108d2054X','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018E%26ES..108d2054X"><span>Low Carbon <span class="hlt">Design</span> Research on the Space Layout <span class="hlt">Types</span> of Office Buildings</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Xia, Bing</p> <p>2018-01-01</p> <p>It is beneficial to find out the relationship of the spatial layout and low-carbon <span class="hlt">design</span> in order to reduce buildings’ carbon emissions in the conceptual <span class="hlt">design</span> phase. This paper analyzes and compares shape coefficient values, annual energy consumption and lighting performance of office buildings of different space layout <span class="hlt">types</span> in Shanghai. Based on morphological characteristics of different <span class="hlt">types</span>, the study also analyzes and presents low-carbon <span class="hlt">design</span> strategies for each single <span class="hlt">type</span>. This study assumes that architects should conduct passive and active <span class="hlt">design</span> according to the specific building space layout, so that to make best use of the advantages and bypassing the disadvantages, in order to maximally reduce buildings’ carbon emissions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol2/pdf/CFR-2010-title49-vol2-sec178-801.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol2/pdf/CFR-2010-title49-vol2-sec178-801.pdf"><span>49 CFR 178.801 - General requirements.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>...: (i) A packaging which differs in surface treatment; (ii) A rigid plastic <span class="hlt">IBC</span> or composite <span class="hlt">IBC</span> which... equipment, etc.); maximum <span class="hlt">IBC</span> capacity; characteristics of test contents; test descriptions and results...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/EJ846728.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/EJ846728.pdf"><span><span class="hlt">Design</span> Patterns for Digital Item <span class="hlt">Types</span> in Higher Education</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Draaijer, S.; Hartog, R. J. M.</p> <p>2007-01-01</p> <p>A set of <span class="hlt">design</span> patterns for digital item <span class="hlt">types</span> has been developed in response to challenges identified in various projects by teachers in higher education. The goal of the projects in question was to <span class="hlt">design</span> and develop formative and summative tests, and to develop interactive learning material in the form of quizzes. The subject domains involved…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017MS%26E..278a2148H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017MS%26E..278a2148H"><span><span class="hlt">Design</span> and test of the Stirling-<span class="hlt">type</span> pulse tube cryocooler</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Hong, Yong-Ju; Ko, Junseok; Kim, Hyo-Bong; Yeom, Han-Kil; In, Sehwan; Park, Seong-Je</p> <p>2017-12-01</p> <p>Stirling <span class="hlt">type</span> pulse tube cryocoolers are very attractive for cooling of diverse application because it has it has several inherent advantages such as no moving part in the cold end, low manufacturing cost and long operation life. To develop the Stirling-<span class="hlt">type</span> pulse tube cryocooler, we need to <span class="hlt">design</span> a linear compressor to drive the pulse tube cryocooler. A moving magnet <span class="hlt">type</span> linear motor of dual piston configuration is <span class="hlt">designed</span> and fabricated, and this compressor could be operated with the electric power of 100 W and the frequency up to 60 Hz. A single stage coaxial <span class="hlt">type</span> pulse tube cold finger aiming at over 1.5 W at 80K is built and tested with the linear compressor. Experimental investigations have been conducted to evaluate their performance characteristics with respect to several parameters such as the phase shifter, the charging pressure and the operating frequency of the linear compressor.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5503225','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5503225"><span>Individual ball possession in soccer</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Hoernig, Martin</p> <p>2017-01-01</p> <p>This paper describes models for detecting individual and team ball possession in soccer based on position data. The <span class="hlt">types</span> of ball possession are classified as Individual Ball Possession (<span class="hlt">IBC</span>), Individual Ball Action (IBA), Individual Ball Control (<span class="hlt">IBC</span>), Team Ball Possession (TBP), Team Ball Control (TBC) und Team Playmaking (TPM) according to different starting points and endpoints and the <span class="hlt">type</span> of ball control involved. The machine learning approach used is able to determine how long the ball spends in the sphere of influence of a player based on the distance between the players and the ball together with their direction of motion, speed and the acceleration of the ball. The degree of ball control exhibited during this phase is classified based on the spatio-temporal configuration of the player controlling the ball, the ball itself and opposing players using a Bayesian network. The evaluation and application of this approach uses data from 60 matches in the German Bundesliga season of 2013/14, including 69,667 IBA intervals. The identification rate was F = .88 for IBA and F = .83 for IBP, and the classification rate for <span class="hlt">IBC</span> was κ = .67. Match analysis showed the following mean values per match: TBP 56:04 ± 5:12 min, TPM 50:01 ± 7:05 min and TBC 17:49 ± 8:13 min. There were 836 ± 424 <span class="hlt">IBC</span> intervals per match and their number was significantly reduced by -5.1% from the 1st to 2nd half. The analysis of ball possession at the player level indicates shortest accumulated <span class="hlt">IBC</span> times for the central forwards (0:49 ± 0:43 min) and the longest for goalkeepers (1:38 ± 0:58 min), central defenders (1:38 ± 1:09 min) and central midfielders (1:27 ± 1:08 min). The results could improve performance analysis in soccer, help to detect match events automatically, and allow discernment of higher value tactical structures, which is based on individual ball possession. PMID:28692649</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2002JCAMD..16..245B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2002JCAMD..16..245B"><span><span class="hlt">Design</span> and synthesis of <span class="hlt">type</span>-III mimetics of ShK toxin</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Baell, Jonathan B.; Harvey, Andrew J.; Norton, Raymond S.</p> <p>2002-04-01</p> <p>ShK toxin is a structurally defined, 35-residue polypeptide which blocks the voltage-gated Kv1.3 potassium channel in T-lymphocytes and has been identified as a possible immunosuppressant. Our interest lies in the rational <span class="hlt">design</span> and synthesis of <span class="hlt">type</span>-III mimetics of protein and polypeptide structure and function. ShK toxin is a challenging target for mimetic <span class="hlt">design</span> as its binding epitope consists of relatively weakly binding residues, some of which are discontinuous. We discuss here our investigations into the <span class="hlt">design</span> and synthesis of 1st generation, small molecule mimetics of ShK toxin and highlight any principles relevant to the generic <span class="hlt">design</span> of <span class="hlt">type</span>-III mimetics of continuous and discontinuous binding epitopes. We complement our approach with attempted pharmacophore-based database mining.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/2065157','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/2065157"><span>Retrofit <span class="hlt">designs</span> for small bench-<span class="hlt">type</span> blood cell counters.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ferris, C D</p> <p>1991-01-01</p> <p>This paper describes several retrofit <span class="hlt">designs</span> to correct operational problems associated with small bench-<span class="hlt">type</span> blood cell counters. Replacement electronic circuits as well as modifications to the vacuum systems are discussed.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li class="active"><span>9</span></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_9 --> <div id="page_10" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li class="active"><span>10</span></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="181"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017CoPhC.217....1J','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017CoPhC.217....1J"><span>Efficient computation of turbulent flow in ribbed passages using a non-overlapping near-wall domain decomposition method</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Jones, Adam; Utyuzhnikov, Sergey</p> <p>2017-08-01</p> <p>Turbulent flow in a ribbed channel is studied using an efficient near-wall domain decomposition (NDD) method. The NDD approach is formulated by splitting the computational domain into an inner and outer region, with an interface boundary between the two. The computational mesh covers the outer region, and the flow in this region is solved using the open-source CFD code Code_Saturne with special boundary conditions on the interface boundary, called interface boundary conditions (<span class="hlt">IBCs</span>). The <span class="hlt">IBCs</span> are of Robin <span class="hlt">type</span> and incorporate the effect of the inner region on the flow in the outer region. <span class="hlt">IBCs</span> are formulated in terms of the distance from the interface boundary to the wall in the inner region. It is demonstrated that up to 90% of the region between the ribs in the ribbed passage can be removed from the computational mesh with an error on the friction factor within 2.5%. In addition, computations with NDD are faster than computations based on low Reynolds number (LRN) models by a factor of five. Different rib heights can be studied with the same mesh in the outer region without affecting the accuracy of the friction factor. This is tested with six different rib heights in an example of a <span class="hlt">design</span> optimisation study. It is found that the friction factors computed with NDD are almost identical to the fully-resolved results. When used for inverse problems, NDD is considerably more efficient than LRN computations because only one computation needs to be performed and only one mesh needs to be generated.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=appliances&pg=5&id=EJ666517','ERIC'); return false;" href="https://eric.ed.gov/?q=appliances&pg=5&id=EJ666517"><span>Use and Rationale of Media <span class="hlt">Types</span> in Performance-Centered <span class="hlt">Design</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Schubert, Dave</p> <p>2002-01-01</p> <p>Focuses on the convergent rationale and use of media within performance centered <span class="hlt">design</span> and how that can affect user performance using real-time electronic performance support system appliance <span class="hlt">design</span>. Discusses the more effective time-based, interactive, and synchronized media <span class="hlt">types</span> that have become viable with technological advancements.…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015MS%26E...99a2028R','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015MS%26E...99a2028R"><span>Health Monitoring System Based on Intra-Body Communication</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Razak, A. H. A.; Ibrahim, I. W.; Ayub, A. H.; Amri, M. F.; Hamzi, M. H.; Halim, A. K.; Ahmad, A.; Junid, S. A. M. Al</p> <p>2015-11-01</p> <p>This paper presents a model of a Body Area Network (BAN) health monitoring system based on Intra-Body Communication. Intra-body Communication (<span class="hlt">IBC</span>) is a communication technique that uses the human body as a medium for electrical signal communication. One of the visions in the health care industry is to provide autonomous and continuous self and the remote health monitoring system. This can be achieved via BAN, LAN and WAN integration. The BAN technology itself consists of short range data communication modules, sensors, controller and actuators. The information can be transmitted to the LAN and WAN via the RF technology such as Bluetooth, ZigBee and ANT. Although the implementations of RF communication have been successful, there are still limitations in term of power consumption, battery lifetime, interferences and signal attenuations. One of the solutions for Medical Body Area Network (MBANs) to overcome these issues is by using an <span class="hlt">IBC</span> technique because it can operate at lower frequencies and power consumption compared to the existing techniques. The first objective is to <span class="hlt">design</span> the <span class="hlt">IBC</span>'s transmitter and receiver modules using the off the shelf components. The specifications of the modules such as frequency, data rate, modulation and demodulation coding system were defined. The individual module were <span class="hlt">designed</span> and tested separately. The modules was integrated as an <span class="hlt">IBC</span> system and tested for functionality then was implemented on PCB. Next objective is to model and implement the digital parts of the transmitter and receiver modules on the Altera's FPGA board. The digital blocks were interfaced with the FPGA's on board modules and the discrete components. The signals that have been received from the transmitter were converted into a proper waveform and it can be viewed via external devices such as oscilloscope and Labview. The signals such as heartbeats or pulses can also be displayed on LCD. In conclusion, the <span class="hlt">IBC</span> project presents medical health monitoring model</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28766916','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28766916"><span>Interleukin-18 (IL-18) is equally expressed in inflammatory breast cancer and noninflammatory locally advanced breast cancer: A possible association with chemotherapy response.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Aguiar, Marco Antonio Nasser; Wanderley, Carlos Wagner S; Nobre, Lívia Maria Soares; Alencar, Mateus Rolim Mendes; Saldanha, Maria do Perpétuo Socorro; Souza, Alceu Machado; Wong, Deysi Viviana Tenazoa; Barros, Paulo Goberlânio; Almeida, Paulo Roberto Carvalho; Lima-Júnior, Roberto Cesar Pereira; Ribeiro, Ronaldo Albuquerque</p> <p>2018-04-01</p> <p>Inflammatory breast cancer (<span class="hlt">IBC</span>) is the most aggressive form of locally advanced breast cancer. The signs of inflammation such as hyperemia and hyperthermia might suggest the possible participation of inflammatory mediators. This study investigates stromal and tumor expression of nuclear factor-kappa B (NF-κB) and interleukin-18 (IL-18) in samples obtained from <span class="hlt">IBC</span> and noninflammatory locally advanced breast cancer (LABC) and the influence of these markers on patients' prognosis. Demographic data, tumor molecular characteristics and overall survival in both groups were also assessed. Furthermore, in this study, we evaluated the expression of IL-18 and p50 nuclear fraction of NF-κB by immunohistochemistry in specimens from <span class="hlt">IBC</span> and LABC (T4b). We observed that 24.6% of women were diagnosed with <span class="hlt">IBC</span> up to age 40. In addition, the patients with <span class="hlt">IBC</span> showed a lower overall survival when compared to LABC. In regard to molecular markers, ER + , C-erbB2 - or triple negative <span class="hlt">IBC</span> patients showed a significantly reduced overall survival. In addition, a higher IL-18 immunostaining in stroma of <span class="hlt">IBC</span> and LABC was observed in comparison with tumor cells, but stromal immunoexpression was similar between <span class="hlt">IBC</span> and LABC. Besides, IL-18 positivity seemed be related with a better clinical response to neoadjuvant chemotherapy. However, NF-κB expression was identical in both groups. The IL-18 is present in tumor stroma of <span class="hlt">IBC</span> and LABC and seems to be associated with the complete response to neoadjuvant chemotherapy. © 2017 John Wiley & Sons Australia, Ltd.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28420119','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28420119"><span>The Modeling and Simulation of the Galvanic Coupling Intra-Body Communication via Handshake Channel.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Li, Maoyuan; Song, Yong; Li, Wansong; Wang, Guangfa; Bu, Tianpeng; Zhao, Yufei; Hao, Qun</p> <p>2017-04-14</p> <p>Intra-body communication (<span class="hlt">IBC</span>) is a technology using the conductive properties of the body to transmit signal, and information interaction by handshake is regarded as one of the important applications of <span class="hlt">IBC</span>. In this paper, a method for modeling the galvanic coupling intra-body communication via handshake channel is proposed, while the corresponding parameters are discussed. Meanwhile, the mathematical model of this kind of <span class="hlt">IBC</span> is developed. Finally, the validity of the developed model has been verified by measurements. Moreover, its characteristics are discussed and compared with that of the <span class="hlt">IBC</span> via single body channel. Our results indicate that the proposed method will lay a foundation for the theoretical analysis and application of the <span class="hlt">IBC</span> via handshake channel.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2013-03-11/pdf/2013-04198.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2013-03-11/pdf/2013-04198.pdf"><span>78 FR 15303 - Hazardous Materials; Miscellaneous Amendments (RRR)</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2013-03-11</p> <p>..., <span class="hlt">designated</span> as sharps, in non-DOT specification containers fitted into wheeled racks. Revise the requirements... regulated medical wastes, <span class="hlt">designated</span> as sharps, in non-DOT specification containers fitted into wheeled... Code Amendment 35-10, section 5.4.1.4.3.2 requires empty uncleaned packagings, <span class="hlt">IBCs</span>, bulk containers...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20040172651&hterms=bacterial+growth&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D20%26Ntt%3Dbacterial%2Bgrowth','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20040172651&hterms=bacterial+growth&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D20%26Ntt%3Dbacterial%2Bgrowth"><span>Two genes with similarity to bacterial response regulators are rapidly and specifically induced by cytokinin in Arabidopsis</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Brandstatter, I.; Kieber, J. J.; Evans, M. L. (Principal Investigator)</p> <p>1998-01-01</p> <p>Cytokinins are central regulators of plant growth and development, but little is known about their mode of action. By using differential display, we identified a gene, <span class="hlt">IBC</span>6 (for induced by cytokinin), from etiolated Arabidopsis seedlings, that is induced rapidly by cytokinin. The steady state level of <span class="hlt">IBC</span>6 mRNA was elevated within 10 min by the exogenous application of cytokinin, and this induction did not require de novo protein synthesis. <span class="hlt">IBC</span>6 was not induced by other plant hormones or by light. A second Arabidopsis gene with a sequence highly similar to <span class="hlt">IBC</span>6 was identified. This <span class="hlt">IBC</span>7 gene also was induced by cytokinin, although with somewhat slower kinetics and to a lesser extent. The pattern of expression of the two genes was similar, with higher expression in leaves, rachises, and flowers and lower transcript levels in roots and siliques. Sequence analysis revealed that <span class="hlt">IBC</span>6 and <span class="hlt">IBC</span>7 are similar to the receiver domain of bacterial two-component response regulators. This homology, coupled with previously published work on the CKI1 histidine kinase homolog, suggests that these proteins may play a role in early cytokinin signaling.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20120006553','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20120006553"><span>Investigation of Rotor Performance and Loads of a UH-60A Individual Blade Control System</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Yeo, Hyeonsoo; Romander, Ethan A.; Norman, Thomas R.</p> <p>2011-01-01</p> <p>Wind tunnel measurements of performance, loads, and vibration of a full-scale UH-60A Black Hawk main rotor with an individual blade control (<span class="hlt">IBC</span>) system are compared with calculations obtained using the comprehensive helicopter analysis CAMRAD II and a coupled CAMRAD II/OVERFLOW 2 analysis. Measured data show a 5.1% rotor power reduction (8.6% rotor lift to effective-drag ratio increase) using 2/rev <span class="hlt">IBC</span> actuation with 2.0 amplitude at = 0.4. At the optimum <span class="hlt">IBC</span> phase for rotor performance, <span class="hlt">IBC</span> actuator force (pitch link force) decreased, and neither flap nor chord bending moments changed significantly. CAMRAD II predicts the rotor power variations with the <span class="hlt">IBC</span> phase reasonably well at = 0.35. However, the correlation degrades at = 0.4. Coupled CAMRAD II/OVERFLOW 2 shows excellent correlation with the measured rotor power variations with the <span class="hlt">IBC</span> phase at both = 0.35 and = 0.4. Maximum reduction of <span class="hlt">IBC</span> actuator force is better predicted with CAMRAD II, but general trends are better captured with the coupled analysis. The correlation of vibratory hub loads is generally poor by both methods, although the coupled analysis somewhat captures general trends.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20100033695','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20100033695"><span>Investigation of Rotor Performance and Loads of a UH-60A Individual Blade Control System</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Yeo, Hyeonsoo; Romander, Ethan A.; Norman, Thomas R.</p> <p>2011-01-01</p> <p>Wind tunnel measurements of performance, loads, and vibration of a full-scale UH-60A Black Hawk main rotor with an individual blade control (<span class="hlt">IBC</span>) system are compared with calculations obtained using the comprehensive helicopter analysis CAMRAD II and a coupled CAMRAD II/OVERFLOW 2 analysis. Measured data show a 5.1% rotor power reduction (8.6% rotor lift to effective-drag ratio increase) using 2/rev <span class="hlt">IBC</span> actuation with 2.0. amplitude at u = 0.4. At the optimum <span class="hlt">IBC</span> phase for rotor performance, <span class="hlt">IBC</span> actuator force (pitch link force) decreased, and neither flap nor chord bending moments changed significantly. CAMRAD II predicts the rotor power variations with <span class="hlt">IBC</span> phase reasonably well at u = 0.35. However, the correlation degrades at u = 0.4. Coupled CAMRAD II/OVERFLOW 2 shows excellent correlation with the measured rotor power variations with <span class="hlt">IBC</span> phase at both u = 0.35 and u = 0.4. Maximum reduction of <span class="hlt">IBC</span> actuator force is better predicted with CAMRAD II, but general trends are better captured with the coupled analysis. The correlation of vibratory hub loads is generally poor by both methods, although the coupled analysis somewhat captures general trends.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/1356649-selective-current-collecting-design-spring-type-energy-harvesters','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/1356649-selective-current-collecting-design-spring-type-energy-harvesters"><span>Selective current collecting <span class="hlt">design</span> for spring-<span class="hlt">type</span> energy harvesters</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Kim, Dongjin; Roh, Hee Seok; Kim, Yeontae</p> <p>2015-01-01</p> <p>Here we present a high performance spring-<span class="hlt">type</span> piezoelectric energy harvester that selectively collects current from the inner part of a spring shell. We analyzed themain reason behind the low efficiency of the initial <span class="hlt">design</span> using finite element models and proposed a selective current collecting <span class="hlt">design</span> that can considerably improve the electrical conversion efficiency of the energy harvester. We found that the newly <span class="hlt">designed</span> energy harvester increases the output voltage by 8 times leading to an output power of 2.21 mW under an impulsive load of 2.18 N when compared with the conventional <span class="hlt">design</span>. We envision that selective current collecting designmore » will be used in spring-based self-powered active sensors and energy scavenging devices.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017SPIE10375E..0TP','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017SPIE10375E..0TP"><span>Contact lens <span class="hlt">design</span> with slope-constrained Q-<span class="hlt">type</span> aspheres for myopia correction</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Peng, Wei-Jei; Cheng, Yuan-Chieh; Hsu, Wei-Yao; Yu, Zong-Ru; Ho, Cheng-Fang; Abou-El-Hossein, Khaled</p> <p>2017-08-01</p> <p>The <span class="hlt">design</span> of the rigid contact lens (CL) with slope-constrained Q-<span class="hlt">type</span> aspheres for myopia correction is presented in this paper. The spherical CL is the most common <span class="hlt">type</span> for myopia correction, however the spherical aberration (SA) caused from the pupil dilation in dark leads to the degradation of visual acuity which cannot be corrected by spherical surface. The spherical and aspheric CLs are <span class="hlt">designed</span> respectively based on Liou's schematic eye model, and the criterion is the modulation transfer function (MTF) at the frequency of 100 line pair per mm, which corresponds to the normal vision of one arc-minute. After optimization, the MTF of the aspheric <span class="hlt">design</span> is superior to that of the spherical <span class="hlt">design</span>, because the aspheric surface corrects the SA for improving the visual acuity in dark. For avoiding the scratch caused from the contact profilometer, the aspheric surface is <span class="hlt">designed</span> to match the measurability of the interferometer. The Q-<span class="hlt">type</span> aspheric surface is employed to constrain the root-mean-square (rms) slope of the departure from a best-fit sphere directly, because the fringe density is limited by the interferometer. The maximum sag departure from a best-fit sphere is also controlled according to the measurability of the aspheric stitching interferometer (ASI). The inflection point is removed during optimization for measurability and appearance. In this study, the aspheric CL is successfully <span class="hlt">designed</span> with Q-<span class="hlt">type</span> aspheres for the measurability of the interferometer. It not only corrects the myopia but also eliminates the SA for improving the visual acuity in dark based on the schematic eye model.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27350472','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27350472"><span>Serious Game Co-<span class="hlt">Design</span> for Children with <span class="hlt">Type</span> 1 Diabetes.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Chomutare, Taridzo; Johansen, Svein-Gunnar; Hartvigsen, Gunnar; Årsand, Eirik</p> <p>2016-01-01</p> <p>Co-<span class="hlt">design</span> or participatory <span class="hlt">design</span> has emerged as a useful concept where stakeholders and end-users have a greater stake in <span class="hlt">designing</span> the end product. To date, few accounts exist of the use of the concept in serious game <span class="hlt">design</span>, especially for children with chronic diseases. We report initial steps in serious game co-<span class="hlt">design</span> for children with <span class="hlt">type</span> 1 diabetes. Participants included 14 children (mean age 8.6 years, range of 4-13) who were invited to sketch a diabetes game. The most prevalent themes that emerged from the sketches (N=17) include blood glucose monitoring (n=12), nutrition (n=8) and insulin (n=8); all of which are consistent with diabetes education guidelines. Co-<span class="hlt">design</span> is a promising concept for understanding children's world-view when <span class="hlt">designing</span> healthcare games.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol2/pdf/CFR-2010-title49-vol2-sec178-810.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol2/pdf/CFR-2010-title49-vol2-sec178-810.pdf"><span>49 CFR 178.810 - Drop test.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... preparation for the drop test. (1) Metal, rigid plastic, and composite <span class="hlt">IBCs</span> intended to contain solids must be.... (4) Rigid plastic <span class="hlt">IBCs</span> and composite <span class="hlt">IBCs</span> with plastic inner receptacles must be conditioned for... material having essentially the same physical characteristics. (3) The specific gravity and viscosity of a...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title19-vol1/pdf/CFR-2011-title19-vol1-sec115-30.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title19-vol1/pdf/CFR-2011-title19-vol1-sec115-30.pdf"><span>19 CFR 115.30 - Technical requirements for containers by <span class="hlt">design</span> <span class="hlt">type</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-04-01</p> <p>... SECURITY; DEPARTMENT OF THE TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO INTERNATIONAL CUSTOMS CONVENTIONS Procedures for Approval of Containers by <span class="hlt">Design</span> <span class="hlt">Type</span> § 115.30 Technical... 19 Customs Duties 1 2011-04-01 2011-04-01 false Technical requirements for containers by <span class="hlt">design</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title19-vol1/pdf/CFR-2012-title19-vol1-sec115-30.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title19-vol1/pdf/CFR-2012-title19-vol1-sec115-30.pdf"><span>19 CFR 115.30 - Technical requirements for containers by <span class="hlt">design</span> <span class="hlt">type</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-04-01</p> <p>... SECURITY; DEPARTMENT OF THE TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO INTERNATIONAL CUSTOMS CONVENTIONS Procedures for Approval of Containers by <span class="hlt">Design</span> <span class="hlt">Type</span> § 115.30 Technical... 19 Customs Duties 1 2012-04-01 2012-04-01 false Technical requirements for containers by <span class="hlt">design</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title19-vol1/pdf/CFR-2014-title19-vol1-sec115-30.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title19-vol1/pdf/CFR-2014-title19-vol1-sec115-30.pdf"><span>19 CFR 115.30 - Technical requirements for containers by <span class="hlt">design</span> <span class="hlt">type</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-04-01</p> <p>... SECURITY; DEPARTMENT OF THE TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO INTERNATIONAL CUSTOMS CONVENTIONS Procedures for Approval of Containers by <span class="hlt">Design</span> <span class="hlt">Type</span> § 115.30 Technical... 19 Customs Duties 1 2014-04-01 2014-04-01 false Technical requirements for containers by <span class="hlt">design</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title19-vol1/pdf/CFR-2010-title19-vol1-sec115-30.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title19-vol1/pdf/CFR-2010-title19-vol1-sec115-30.pdf"><span>19 CFR 115.30 - Technical requirements for containers by <span class="hlt">design</span> <span class="hlt">type</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-04-01</p> <p>... SECURITY; DEPARTMENT OF THE TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO INTERNATIONAL CUSTOMS CONVENTIONS Procedures for Approval of Containers by <span class="hlt">Design</span> <span class="hlt">Type</span> § 115.30 Technical... 19 Customs Duties 1 2010-04-01 2010-04-01 false Technical requirements for containers by <span class="hlt">design</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title19-vol1/pdf/CFR-2013-title19-vol1-sec115-30.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title19-vol1/pdf/CFR-2013-title19-vol1-sec115-30.pdf"><span>19 CFR 115.30 - Technical requirements for containers by <span class="hlt">design</span> <span class="hlt">type</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-04-01</p> <p>... SECURITY; DEPARTMENT OF THE TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO INTERNATIONAL CUSTOMS CONVENTIONS Procedures for Approval of Containers by <span class="hlt">Design</span> <span class="hlt">Type</span> § 115.30 Technical... 19 Customs Duties 1 2013-04-01 2013-04-01 false Technical requirements for containers by <span class="hlt">design</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5424740','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5424740"><span>The Modeling and Simulation of the Galvanic Coupling Intra-Body Communication via Handshake Channel</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Li, Maoyuan; Song, Yong; Li, Wansong; Wang, Guangfa; Bu, Tianpeng; Zhao, Yufei; Hao, Qun</p> <p>2017-01-01</p> <p>Intra-body communication (<span class="hlt">IBC</span>) is a technology using the conductive properties of the body to transmit signal, and information interaction by handshake is regarded as one of the important applications of <span class="hlt">IBC</span>. In this paper, a method for modeling the galvanic coupling intra-body communication via handshake channel is proposed, while the corresponding parameters are discussed. Meanwhile, the mathematical model of this kind of <span class="hlt">IBC</span> is developed. Finally, the validity of the developed model has been verified by measurements. Moreover, its characteristics are discussed and compared with that of the <span class="hlt">IBC</span> via single body channel. Our results indicate that the proposed method will lay a foundation for the theoretical analysis and application of the <span class="hlt">IBC</span> via handshake channel. PMID:28420119</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19890006960','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19890006960"><span>Some <span class="hlt">design</span> constraints required for the assembly of software components: The incorporation of atomic abstract <span class="hlt">types</span> into generically structured abstract <span class="hlt">types</span></span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Johnson, Charles S.</p> <p>1986-01-01</p> <p>It is nearly axiomatic, that to take the greatest advantage of the useful features available in a development system, and to avoid the negative interactions of those features, requires the exercise of a <span class="hlt">design</span> methodology which constrains their use. A major <span class="hlt">design</span> support feature of the Ada language is abstraction: for data, functions processes, resources, and system elements in general. Atomic abstract <span class="hlt">types</span> can be created in packages defining those private <span class="hlt">types</span> and all of the overloaded operators, functions, and hidden data required for their use in an application. Generically structured abstract <span class="hlt">types</span> can be created in generic packages defining those structured private <span class="hlt">types</span>, as buildups from the user-defined data <span class="hlt">types</span> which are input as parameters. A study is made of the <span class="hlt">design</span> constraints required for software incorporating either atomic or generically structured abstract <span class="hlt">types</span>, if the integration of software components based on them is to be subsequently performed. The impact of these techniques on the reusability of software and the creation of project-specific software support environments is also discussed.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li class="active"><span>10</span></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_10 --> <div id="page_11" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li class="active"><span>11</span></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="201"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1369116','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1369116"><span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Warren, Emily L.; Deceglie, Michael G.; Stradins, Paul</p> <p></p> <p>Three-terminal (3T) tandem cells fabricated by combining an interdigitated back contact (<span class="hlt">IBC</span>) Si device with a wider bandgap top cell have the potential to provide a robust operating mechanism to efficiently capture the solar spectrum without the need to current match sub-cells or fabricate complicated metal interconnects between cells. Here we develop a two dimensional device physics model to study the behavior of <span class="hlt">IBC</span> Si solar cells operated in a 3T configuration. We investigate how different cell <span class="hlt">designs</span> impact device performance and discuss the analysis protocol used to understand and optimize power produced from a single junction, 3T device.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22458683-high-density-very-low-density-lipoproteinhave-opposing-roles-regulating-tumor-initiating-cells-sensitivity-radiation-inflammatory-breast-cancer','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22458683-high-density-very-low-density-lipoproteinhave-opposing-roles-regulating-tumor-initiating-cells-sensitivity-radiation-inflammatory-breast-cancer"><span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Wolfe, Adam R.; Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, University of Texas MD Anderson Cancer Center, Houston, Texas; Atkinson, Rachel L.</p> <p></p> <p>Purpose: We previously demonstrated that cholesterol-lowering agents regulate radiation sensitivity of inflammatory breast cancer (<span class="hlt">IBC</span>) cell lines in vitro and are associated with less radiation resistance among <span class="hlt">IBC</span> patients who undergo postmastectomy radiation. We hypothesized that decreasing <span class="hlt">IBC</span> cellular cholesterol induced by treatment with lipoproteins would increase radiation sensitivity. Here, we examined the impact of specific transporters of cholesterol (ie lipoproteins) on the responses of <span class="hlt">IBC</span> cells to self-renewal and to radiation in vitro and on clinical outcomes in <span class="hlt">IBC</span> patients. Methods and Materials: Two patient-derived <span class="hlt">IBC</span> cell lines, SUM 149 and KPL4, were incubated with low-density lipoproteins (LDL), very-low-density lipoproteins (VLDL),more » or high-density lipoproteins (HDL) for 24 hours prior to irradiation (0-6 Gy) and mammosphere formation assay. Cholesterol panels were examined in a cohort of patients with primary <span class="hlt">IBC</span> diagnosed between 1995 and 2011 at MD Anderson Cancer Center. Lipoprotein levels were then correlated to patient outcome, using the log rank statistical model, and examined in multivariate analysis using Cox regression. Results: VLDL increased and HDL decreased mammosphere formation compared to untreated SUM 149 and KPL4 cells. Survival curves showed enhancement of survival in both of the <span class="hlt">IBC</span> cell lines when pretreated with VLDL and, conversely, radiation sensitization in all cell lines when pretreated with HDL. In <span class="hlt">IBC</span> patients, higher VLDL values (>30 mg/dL) predicted a lower 5-year overall survival rate than normal values (hazard ratio [HR] = 1.9 [95% confidence interval [CI]: 1.05-3.45], P=.035). Lower-than-normal patient HDL values (<60 mg/dL) predicted a lower 5-year overall survival rate than values higher than 60 mg/dL (HR = 3.21 [95% CI: 1.25-8.27], P=.015). Conclusions: This study discovered a relationship among the plasma levels of lipoproteins, overall patient response, and radiation resistance in <span class="hlt">IBC</span></p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23420611','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23420611"><span>Characterizing inflammatory breast cancer among Arab Americans in the California, Detroit and New Jersey Surveillance, Epidemiology and End Results (SEER) registries (1988-2008).</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hirko, Kelly A; Soliman, Amr S; Banerjee, Mousumi; Ruterbusch, Julie; Harford, Joe B; Chamberlain, Robert M; Graff, John J; Merajver, Sofia D; Schwartz, Kendra</p> <p>2013-12-01</p> <p>Inflammatory breast cancer (<span class="hlt">IBC</span>) is characterized by an apparent geographical distribution in incidence, being more common in North Africa than other parts of the world. Despite the rapid growth of immigrants to the United States from Arab nations, little is known about disease patterns among Arab Americans because a racial category is rarely considered for this group. The aim of this study was to advance our understanding of the burden of <span class="hlt">IBC</span> in Arab ethnic populations by describing the proportion of <span class="hlt">IBC</span> among different racial groups, including Arab Americans from the Detroit, New Jersey and California Surveillance, Epidemiology and End Results (SEER) registries. We utilized a validated Arab surname algorithm to identify women of Arab descent from the SEER registries. Differences in the proportion of <span class="hlt">IBC</span> out of all breast cancer and <span class="hlt">IBC</span> characteristics by race and menopausal status were evaluated using chi-square tests for categorical variables, t-tests and ANOVA tests for continuous variables, and log-rank tests for survival data. We modeled the association between race and <span class="hlt">IBC</span> among all women with breast cancer using hierarchical logistic regression models, adjusting for individual and census tract-level variables. Statistically significant differences in the proportion of <span class="hlt">IBC</span> out of all breast cancers by race were evident. In a hierarchical model, adjusting for age, estrogen and progesterone receptor, human epidermal growth receptor 2, registry and census-tract level education, Arab-Americans (OR=1.5, 95% CI=1.2,1.9), Hispanics (OR=1.2, 95% CI=1.1,1.3), Non-Hispanic Blacks (OR=1.3, 95% CI=1.2, 1.4), and American Indians/Alaskans (OR=1.9, 95% CI=1.1, 3.4) had increased odds of <span class="hlt">IBC</span>, while Asians (OR=0.6, 95% CI=0.6, 0.7) had decreased odds of <span class="hlt">IBC</span> as compared to Non-Hispanic Whites. <span class="hlt">IBC</span> may be more common among certain minority groups, including Arab American women. Understanding the descriptive epidemiology of <span class="hlt">IBC</span> by race may generate hypotheses about risk</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=methodological+AND+design&pg=4&id=EJ1056680','ERIC'); return false;" href="https://eric.ed.gov/?q=methodological+AND+design&pg=4&id=EJ1056680"><span>Estimating Intervention Effects across Different <span class="hlt">Types</span> of Single-Subject Experimental <span class="hlt">Designs</span>: Empirical Illustration</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Moeyaert, Mariola; Ugille, Maaike; Ferron, John M.; Onghena, Patrick; Heyvaert, Mieke; Beretvas, S. Natasha; Van den Noortgate, Wim</p> <p>2015-01-01</p> <p>The purpose of this study is to illustrate the multilevel meta-analysis of results from single-subject experimental <span class="hlt">designs</span> of different <span class="hlt">types</span>, including AB phase <span class="hlt">designs</span>, multiple-baseline <span class="hlt">designs</span>, ABAB reversal <span class="hlt">designs</span>, and alternating treatment <span class="hlt">designs</span>. Current methodological work on the meta-analysis of single-subject experimental designs…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title14-vol1/pdf/CFR-2012-title14-vol1-sec21-93.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title14-vol1/pdf/CFR-2012-title14-vol1-sec21-93.pdf"><span>14 CFR 21.93 - Classification of changes in <span class="hlt">type</span> <span class="hlt">design</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-01-01</p> <p>... (a) of this section) for the following aircraft: (1) Transport category large airplanes. (2) Jet... chapter, any voluntary change in the <span class="hlt">type</span> <span class="hlt">design</span> of the airplane or engine which may increase fuel venting...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title14-vol1/pdf/CFR-2011-title14-vol1-sec21-93.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title14-vol1/pdf/CFR-2011-title14-vol1-sec21-93.pdf"><span>14 CFR 21.93 - Classification of changes in <span class="hlt">type</span> <span class="hlt">design</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-01-01</p> <p>... (a) of this section) for the following aircraft: (1) Transport category large airplanes. (2) Jet... chapter, any voluntary change in the <span class="hlt">type</span> <span class="hlt">design</span> of the airplane or engine which may increase fuel venting...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title14-vol1/pdf/CFR-2013-title14-vol1-sec21-93.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title14-vol1/pdf/CFR-2013-title14-vol1-sec21-93.pdf"><span>14 CFR 21.93 - Classification of changes in <span class="hlt">type</span> <span class="hlt">design</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-01-01</p> <p>... (a) of this section) for the following aircraft: (1) Transport category large airplanes. (2) Jet... chapter, any voluntary change in the <span class="hlt">type</span> <span class="hlt">design</span> of the airplane or engine which may increase fuel venting...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title14-vol3/pdf/CFR-2010-title14-vol3-sec121-162.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title14-vol3/pdf/CFR-2010-title14-vol3-sec121-162.pdf"><span>14 CFR 121.162 - ETOPS <span class="hlt">Type</span> <span class="hlt">Design</span> Approval Basis.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-01-01</p> <p>... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false ETOPS <span class="hlt">Type</span> <span class="hlt">Design</span> Approval Basis. 121.162 Section 121.162 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS AND OPERATORS FOR COMPENSATION OR HIRE: CERTIFICATION AND OPERATIONS OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28302157','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28302157"><span>Reliability of medical records in diagnosing inflammatory breast cancer in Egypt.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Le, Lynne; Schairer, Catherine; Hablas, Ahmed; Meza, Jane; Watanabe-Galloway, Shinobu; Ramadan, Mohamed; Merajver, Sofia D; Seifeldin, Ibrahim A; Soliman, Amr S</p> <p>2017-03-16</p> <p>Inflammatory breast cancer (<span class="hlt">IBC</span>) is a rare, aggressive breast cancer diagnosed clinically by the presence of diffuse erythema, peau d'orange, and edema that arise quickly in the affected breast. This study evaluated the validity of medical records in Gharbiah, Egypt in identifying clinical signs/symptoms of <span class="hlt">IBC</span>. For 34 <span class="hlt">IBC</span> cases enrolled in a case-control study at the Gharbiah Cancer Society and Tanta Cancer Center, Egypt (2009-2010), we compared signs/symptoms of <span class="hlt">IBC</span> noted in medical records to those recorded on a standardized form at the time of <span class="hlt">IBC</span> diagnosis by clinicians participating in the case-control study. We calculated the sensitivity and specificity of medical records as compared to the case-control study for recording these signs/symptoms. We also performed McNemar's tests. In the case-control study, 32 (94.1%) <span class="hlt">IBC</span> cases presented with peau d'orange, 30 (88.2%) with erythema, and 31 (91.2%) with edema. The sensitivities of the medical records as compared to the case-control study were 0.8, 0.5, and 0.2 for peau d'orange, erythema, and edema, respectively. Corresponding specificities were 1.0, 0.5, and 1.0. p values for McNemar's test were <0.05 for all signs. Medical records had data on the extent and duration of signs for at most 27% of cases for which this information was recorded in the case-control study. Twenty-three of the 34 cases (67.6%) had confirmed diagnosis of <span class="hlt">IBC</span> in their medical records. Medical records lacked information on signs/symptoms of <span class="hlt">IBC</span>, especially erythema and edema, when compared to the case-control study. Deficient medical records could have implications for diagnosis and treatment of <span class="hlt">IBC</span> and proper documentation of cases in cancer registries.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26797453','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26797453"><span>Epidemiological risk factors associated with inflammatory breast cancer subtypes.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Atkinson, Rachel L; El-Zein, Randa; Valero, Vicente; Lucci, Anthony; Bevers, Therese B; Fouad, Tamer; Liao, Weiqin; Ueno, Naoto T; Woodward, Wendy A; Brewster, Abenaa M</p> <p>2016-03-01</p> <p>In this single-institution case-control study, we identified risk factors associated with inflammatory breast cancer (<span class="hlt">IBC</span>) subtypes based on staining of estrogen receptor (ER), progesterone receptor (PR) and expression of human epidermal growth factor 2 (HER2neu) to determine distinct etiologic pathways. We identified 224 women with <span class="hlt">IBC</span> and 396 cancer-free women seen at the MD Anderson Cancer Center. Multinomial logistic regression was used to estimate odds ratios (ORs) and 95 % confidence intervals (CIs) for associations between breast cancer risk factors and the <span class="hlt">IBC</span> tumor subtypes: luminal (ER+ and/or PR+/HER2neu-), HER2neu+ (any ER and PR, HER2neu+), and triple-negative (ER-/PR-/HER2neu-). In multivariable analysis, compared with women age ≥26 at first pregnancy, women age <26 had a higher risk of triple-negative <span class="hlt">IBC</span> (OR 3.32, 95% CI 1.37-8.05). Women with a history of breast-feeding had a lower risk of triple-negative (OR 0.30; 95% CI 0.15-0.62) and luminal <span class="hlt">IBC</span> (OR 0.35, 95% CI 0.18-0.68). A history of smoking was associated with an increased risk of luminal <span class="hlt">IBC</span> (OR 2.37; 95% CI 1.24-4.52). Compared with normal-weight women, those who were overweight or obese (body mass index ≥25 kg/m(2)) had a higher risk of all three tumor subtypes (p < 0.01 for all subtypes). Overweight or obese status is important modifiable risk factor for <span class="hlt">IBC</span> of any subtype. Modifiable risk factors, age at first pregnancy (≥26), breast-feeding, and smoking may be associated with specific <span class="hlt">IBC</span> subtypes. These results highlight the importance of evaluating epidemiologic risk factors for <span class="hlt">IBC</span> for the identification of subtype-specific prevention strategies.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=Local+AND+impacts+AND+environment&id=EJ946019','ERIC'); return false;" href="https://eric.ed.gov/?q=Local+AND+impacts+AND+environment&id=EJ946019"><span>Global Expansion of International Branch Campuses: Managerial and Leadership Challenges</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Lane, Jason E.</p> <p>2011-01-01</p> <p>In this chapter, the author outlines the growth of international branch campuses (<span class="hlt">IBCs</span>) over the past fifty years and discusses some of the major management and leadership challenges associated with creating and sustaining <span class="hlt">IBCs</span>. Part one of the chapter provides a discussion of the global expansion of <span class="hlt">IBCs</span>. The second part focuses on the…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=international+AND+branch+AND+campuse&pg=2&id=EJ1019884','ERIC'); return false;" href="https://eric.ed.gov/?q=international+AND+branch+AND+campuse&pg=2&id=EJ1019884"><span>Legitimacy in Cross-Border Higher Education: Identifying Stakeholders of International Branch Campuses</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Farrugia, Christine A.; Lane, Jason E.</p> <p>2013-01-01</p> <p>When colleges and universities set up outposts such as international branch campuses (<span class="hlt">IBCs</span>) in foreign countries, the literature suggests that the success of that outpost can be tied to its ability to build its own legitimacy. This article investigates the process of legitimacy building by <span class="hlt">IBCs</span> through identifying who <span class="hlt">IBCs</span> view as their salient…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/18386970','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/18386970"><span>An evaluation of the role and effectiveness of institutional biosafety committees in providing oversight and security at biocontainment laboratories.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Race, Margaret S; Hammond, Edward</p> <p>2008-03-01</p> <p>Institutional biosafety committees (<span class="hlt">IBCs</span>) have been charged with the oversight and review of biosafety at thousands of biocontainment labs nationwide, hundreds of which are high-level BSL-3 and BSL-4 labs. In light of the recent rapid proliferation of BSL-3 and BSL-4 facilities and the increases in research in the areas of biodefense, select agents, recombinant DNA, and synthetic biology and dual-use research, questions have been raised about whether <span class="hlt">IBCs</span> are fulfilling their oversight responsibilities. This article reviews information on the responsibilities and expectations of <span class="hlt">IBCs</span> as currently constituted and provides an analysis of <span class="hlt">IBC</span> performance from survey data of hundreds of research institutions over the past several years. The findings highlight serious ongoing problems with <span class="hlt">IBCs</span>' adherence to NIH Guidelines. This raises questions about the current voluntary governance framework as an effective system to monitor and oversee U.S. research facilities, including high-containment facilities, and their research activities. The findings strongly suggest the need for immediate improvement or replacement of the <span class="hlt">IBC</span> system.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title27-vol1/pdf/CFR-2010-title27-vol1-sec4-28.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title27-vol1/pdf/CFR-2010-title27-vol1-sec4-28.pdf"><span>27 CFR 4.28 - <span class="hlt">Type</span> <span class="hlt">designations</span> of varietal significance.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-04-01</p> <p>... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false <span class="hlt">Type</span> <span class="hlt">designations</span> of varietal significance. 4.28 Section 4.28 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND... and separated by the required appellation of origin, the name(s) of the grape variety or varieties...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=international+AND+branch+AND+campuse&pg=4&id=EJ946021','ERIC'); return false;" href="https://eric.ed.gov/?q=international+AND+branch+AND+campuse&pg=4&id=EJ946021"><span>Institutional Ethos: Replicating the Student Experience</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Wood, Cynthia Howman</p> <p>2011-01-01</p> <p>International branch campuses (<span class="hlt">IBCs</span>) have been established in significant numbers over the past ten years. A common criticism of <span class="hlt">IBCs</span> is that they cannot recreate the student culture of the home campus. While this is true, some <span class="hlt">IBCs</span> have gone to great lengths not only to create a comparable culture for their students, but also to integrate their…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=alien&pg=2&id=EJ1087017','ERIC'); return false;" href="https://eric.ed.gov/?q=alien&pg=2&id=EJ1087017"><span>The Challenges of Leading an International Branch Campus: The "Lived Experience" of In-Country Senior Managers</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Healey, Nigel M.</p> <p>2016-01-01</p> <p>In recent years, an increasing number of major universities have set up international branch campuses (<span class="hlt">IBCs</span>). There are now more than 200 <span class="hlt">IBCs</span>, with more under development. Little is known about the unique challenges that face <span class="hlt">IBC</span> managers, who are normally seconded from the home university to set up and operate the satellite campus in a new and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=stakeholder+AND+interest&pg=4&id=EJ1077750','ERIC'); return false;" href="https://eric.ed.gov/?q=stakeholder+AND+interest&pg=4&id=EJ1077750"><span>Managing International Branch Campuses: What Do We Know?</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Healey, Nigel</p> <p>2015-01-01</p> <p>Over the last decade, the growth of the international branch campus (<span class="hlt">IBC</span>) has been one of the most striking developments in the internationalisation of higher education. There are now over 200 <span class="hlt">IBCs</span> across the world, mostly in the Middle East and East and South-east Asia. Despite the growing numbers of <span class="hlt">IBCs</span> and the considerable financial and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title49-vol2/pdf/CFR-2013-title49-vol2-sec173-247.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title49-vol2/pdf/CFR-2013-title49-vol2-sec173-247.pdf"><span>49 CFR 173.247 - Bulk packaging for certain elevated temperature materials.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-10-01</p> <p>... motor vehicles; and non-DOT specification cargo tank motor vehicles equivalent in structural <span class="hlt">design</span> and...; metal <span class="hlt">IBCs</span> and non-specification portable tanks equivalent in structural <span class="hlt">design</span> and accident damage...; Class DOT 106, 110 multi-unit tank car tanks; AAR Class 203W, 206W, 211W tank car tanks; and non-DOT...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title49-vol2/pdf/CFR-2011-title49-vol2-sec173-247.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title49-vol2/pdf/CFR-2011-title49-vol2-sec173-247.pdf"><span>49 CFR 173.247 - Bulk packaging for certain elevated temperature materials.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-10-01</p> <p>... motor vehicles; and non-DOT specification cargo tank motor vehicles equivalent in structural <span class="hlt">design</span> and...; metal <span class="hlt">IBCs</span> and non-specification portable tanks equivalent in structural <span class="hlt">design</span> and accident damage...; Class DOT 106, 110 multi-unit tank car tanks; AAR Class 203W, 206W, 211W tank car tanks; and non-DOT...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol2/pdf/CFR-2010-title49-vol2-sec173-247.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol2/pdf/CFR-2010-title49-vol2-sec173-247.pdf"><span>49 CFR 173.247 - Bulk packaging for certain elevated temperature materials.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... motor vehicles; and non-DOT specification cargo tank motor vehicles equivalent in structural <span class="hlt">design</span> and...; metal <span class="hlt">IBCs</span> and non-specification portable tanks equivalent in structural <span class="hlt">design</span> and accident damage...; Class DOT 106, 110 multi-unit tank car tanks; AAR Class 203W, 206W, 211W tank car tanks; and non-DOT...</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li class="active"><span>11</span></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_11 --> <div id="page_12" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li class="active"><span>12</span></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="221"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title49-vol2/pdf/CFR-2014-title49-vol2-sec173-247.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title49-vol2/pdf/CFR-2014-title49-vol2-sec173-247.pdf"><span>49 CFR 173.247 - Bulk packaging for certain elevated temperature materials.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-10-01</p> <p>... motor vehicles; and non-DOT specification cargo tank motor vehicles equivalent in structural <span class="hlt">design</span> and...; metal <span class="hlt">IBCs</span> and non-specification portable tanks equivalent in structural <span class="hlt">design</span> and accident damage...; Class DOT 106, 110 multi-unit tank car tanks; AAR Class 203W, 206W, 211W tank car tanks; and non-DOT...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22446725','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22446725"><span>Irregular breakfast consumption in adolescence and the family environment: underlying causes by family structure.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Levin, Kate A; Kirby, Joanna</p> <p>2012-08-01</p> <p>Data from the 2002, 2006 and 2010 Scottish Health Behaviour in School-aged Children (HBSC) surveys were analysed using logistic multilevel regression for outcome variable irregular breakfast consumption (<span class="hlt">IBC</span>). <span class="hlt">IBC</span> prevalence in Scotland was higher among young people from reconstituted and single parent families, and particularly single father families. Family characteristics, found previously to be associated with breakfast consumption, such as number of siblings, perceived parenting, parental involvement and family affluence, differed by family structure. Family structure inequalities in <span class="hlt">IBC</span> existed, also after adjustment for year and child's sex, age, grade and ethnicity. Across all family structures, <span class="hlt">IBC</span> was more prevalent at the older age groups, among those who had difficult communication with their parents, and where household routines were infrequent. Greater number of siblings and lower family affluence were associated with higher odds of <span class="hlt">IBC</span> in single mother and both parent families, while having a second home was associated with higher odds in reconstituted households. Fair parenting and being close to at least one parent was associated with reduced odds of <span class="hlt">IBC</span> in single mother households, while being close to all parents was in single father households. In single mother homes, having a working mother was also positively associated with <span class="hlt">IBC</span>. Family structure differences should be considered when addressing irregular breakfast consumption in adolescence. Copyright © 2012 Elsevier Ltd. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=design+AND+experiments&pg=4&id=EJ1152231','ERIC'); return false;" href="https://eric.ed.gov/?q=design+AND+experiments&pg=4&id=EJ1152231"><span>Role of Cultural Inspiration with Different <span class="hlt">Types</span> in Cultural Product <span class="hlt">Design</span> Activities</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Luo, Shi-Jian; Dong, Ye-Nan</p> <p>2017-01-01</p> <p>Inspiration plays an important role in the <span class="hlt">design</span> activities and <span class="hlt">design</span> education. This paper describes "ancient cultural artefacts" as "cultural inspiration," consisting of two <span class="hlt">types</span> called "cultural-pictorial inspiration" (CPI) and "cultural-textual inspiration" (CTI). This study aims to test the important…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1982pvsp.conf..828S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1982pvsp.conf..828S"><span>The <span class="hlt">design</span> and development of a rectangular, shingle-<span class="hlt">type</span> photovoltaic module</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Shepard, N. F., Jr.</p> <p></p> <p>A shingle-<span class="hlt">type</span> photovoltaic module has been <span class="hlt">designed</span> and developed to meet the requirements of specifications for residential applications. The module is ideally suited for installation directly to the sheathing of a sloping, south-facing roof of a residential, industrial, or commercial building. The <span class="hlt">design</span> requirements are examined, taking into account also module safety requirements. Aspects of module <span class="hlt">design</span> and analysis are discussed, giving attention to installation details, solar cells and electrical circuit <span class="hlt">design</span>, the encapsulation system, substrate lamination, and the module-to-module interconnecting cable. Details of module assembly experience and test and outdoor exposure experience are also considered.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19840040280&hterms=solar+shingles&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3Dsolar%2Bshingles','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19840040280&hterms=solar+shingles&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3Dsolar%2Bshingles"><span>The <span class="hlt">design</span> and development of a rectangular, shingle-<span class="hlt">type</span> photovoltaic module</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Shepard, N. F., Jr.</p> <p>1982-01-01</p> <p>A shingle-<span class="hlt">type</span> photovoltaic module has been <span class="hlt">designed</span> and developed to meet the requirements of specifications for residential applications. The module is ideally suited for installation directly to the sheathing of a sloping, south-facing roof of a residential, industrial, or commercial building. The <span class="hlt">design</span> requirements are examined, taking into account also module safety requirements. Aspects of module <span class="hlt">design</span> and analysis are discussed, giving attention to installation details, solar cells and electrical circuit <span class="hlt">design</span>, the encapsulation system, substrate lamination, and the module-to-module interconnecting cable. Details of module assembly experience and test and outdoor exposure experience are also considered.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/6421028-development-tf-coil-support-concepts-design-methodology-case-bitter-type-magnet-bitter-type-magnets','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/6421028-development-tf-coil-support-concepts-design-methodology-case-bitter-type-magnet-bitter-type-magnets"><span>Development of tf coil support concepts by <span class="hlt">design</span> methodology in the case of a Bitter-<span class="hlt">type</span> magnet. [Bitter-<span class="hlt">type</span> magnets</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Brossmann, U.B.</p> <p>1981-01-01</p> <p>The application of the methodological <span class="hlt">design</span> is demonstrated for the development of support concepts in the case of a Bitter-<span class="hlt">type</span> magnet <span class="hlt">designed</span> for a compact tokamak experimentat aiming at ignition of a DT plasma. With this methodology all boundary conditions and <span class="hlt">design</span> criteria are more easily satisfied in a technical and economical way.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19902352','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19902352"><span>GPR30 and estrogen receptor expression: new insights into hormone dependence of inflammatory breast cancer.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Arias-Pulido, Hugo; Royce, Melanie; Gong, Yun; Joste, Nancy; Lomo, Lesley; Lee, Sang-Joon; Chaher, Nabila; Verschraegen, Claire; Lara, Juanita; Prossnitz, Eric R; Cristofanilli, Massimo</p> <p>2010-08-01</p> <p>GPR30 is a novel G protein-coupled estrogen receptor (ER) associated with metastases in breast cancer (BC) and poor survival in endometrial and ovarian tumors. The association of GPR30 expression with inflammatory breast cancer (<span class="hlt">IBC</span>), an aggressive and commonly hormone-independent form of BC, has not been studied. GPR30, ER, progesterone receptor (PR), epidermal growth factor receptor (EGFR), and HER-2 expression were assessed by immunohistochemistry (and FISH for HER-2) in 88 primary <span class="hlt">IBCs</span>. GPR30 expression was correlated with patient overall survival (OS), disease-free survival (DFS), pathologic variables, and other biomarkers. GPR30 expression was found in 69% of <span class="hlt">IBC</span> cases. ER, PR, HER-2, and EGFR were found in 43, 35, 39, and 34% of <span class="hlt">IBC</span> cases, respectively. GPR30 expression correlated inversely with ER expression (P = 0.02). Co-expression of ER and GPR30 was found in 24% of <span class="hlt">IBC</span> samples; 19% expressed only ER and 46% expressed only GPR30. Univariate analysis showed no association between GPR30 expression and OS or DFS. However, co-expression of ER and GPR30 was associated with improved OS (P < 0.03) and marginally with DFS (P < 0.06); the absence of both ER and GPR30 was associated with worse OS and DFS (P = 0.03 for both). Multivariate analysis identified ER as an independent prognostic factor of OS (P = 0.008) and DFS (P = 0.02). The majority of <span class="hlt">IBC</span> tumors are GPR30-positive, suggesting that estrogen signaling may be active in ER-negative <span class="hlt">IBC</span> patients. These findings suggest potential new therapeutic targets for <span class="hlt">IBC</span> such as novel endocrine agents or direct modulation of GPR30.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3585368','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3585368"><span>Anti-Tumor Effects of Ganoderma lucidum (Reishi) in Inflammatory Breast Cancer in In Vivo and In Vitro Models</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Suarez-Arroyo, Ivette J.; Rosario-Acevedo, Raysa; Aguilar-Perez, Alexandra; Clemente, Pedro L.; Cubano, Luis A.; Serrano, Juan; Schneider, Robert J.; Martínez-Montemayor, Michelle M.</p> <p>2013-01-01</p> <p>The medicinal mushroom Ganoderma lucidum (Reishi) was tested as a potential therapeutic for Inflammatory Breast Cancer (<span class="hlt">IBC</span>) using in vivo and in vitro <span class="hlt">IBC</span> models. <span class="hlt">IBC</span> is a lethal and aggressive form of breast cancer that manifests itself without a typical tumor mass. Studies show that <span class="hlt">IBC</span> tissue biopsies overexpress E-cadherin and the eukaryotic initiation factor 4GI (eIF4GI), two proteins that are partially responsible for the unique pathological properties of this disease. <span class="hlt">IBC</span> is treated with a multimodal approach that includes non-targeted systemic chemotherapy, surgery, and radiation. Because of its non-toxic and selective anti-cancer activity, medicinal mushroom extracts have received attention for their use in cancer therapy. Our previous studies demonstrate these selective anti-cancer effects of Reishi, where <span class="hlt">IBC</span> cell viability and invasion, as well as the expression of key <span class="hlt">IBC</span> molecules, including eIF4G is compromised. Thus, herein we define the mechanistic effects of Reishi focusing on the phosphoinositide-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, a regulator of cell survival and growth. The present study demonstrates that Reishi treated <span class="hlt">IBC</span> SUM-149 cells have reduced expression of mTOR downstream effectors at early treatment times, as we observe reduced eIF4G levels coupled with increased levels of eIF4E bound to 4E-BP, with consequential protein synthesis reduction. Severe combined immunodeficient mice injected with <span class="hlt">IBC</span> cells treated with Reishi for 13 weeks show reduced tumor growth and weight by ∼50%, and Reishi treated tumors showed reduced expression of E-cadherin, mTOR, eIF4G, and p70S6K, and activity of extracellular regulated kinase (ERK1/2). Our results provide evidence that Reishi suppresses protein synthesis and tumor growth by affecting survival and proliferative signaling pathways that act on translation, suggesting that Reishi is a potential natural therapeutic for breast and other cancers. PMID:23468988</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23468988','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23468988"><span>Anti-tumor effects of Ganoderma lucidum (reishi) in inflammatory breast cancer in in vivo and in vitro models.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Suarez-Arroyo, Ivette J; Rosario-Acevedo, Raysa; Aguilar-Perez, Alexandra; Clemente, Pedro L; Cubano, Luis A; Serrano, Juan; Schneider, Robert J; Martínez-Montemayor, Michelle M</p> <p>2013-01-01</p> <p>The medicinal mushroom Ganoderma lucidum (Reishi) was tested as a potential therapeutic for Inflammatory Breast Cancer (<span class="hlt">IBC</span>) using in vivo and in vitro <span class="hlt">IBC</span> models. <span class="hlt">IBC</span> is a lethal and aggressive form of breast cancer that manifests itself without a typical tumor mass. Studies show that <span class="hlt">IBC</span> tissue biopsies overexpress E-cadherin and the eukaryotic initiation factor 4GI (eIF4GI), two proteins that are partially responsible for the unique pathological properties of this disease. <span class="hlt">IBC</span> is treated with a multimodal approach that includes non-targeted systemic chemotherapy, surgery, and radiation. Because of its non-toxic and selective anti-cancer activity, medicinal mushroom extracts have received attention for their use in cancer therapy. Our previous studies demonstrate these selective anti-cancer effects of Reishi, where <span class="hlt">IBC</span> cell viability and invasion, as well as the expression of key <span class="hlt">IBC</span> molecules, including eIF4G is compromised. Thus, herein we define the mechanistic effects of Reishi focusing on the phosphoinositide-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, a regulator of cell survival and growth. The present study demonstrates that Reishi treated <span class="hlt">IBC</span> SUM-149 cells have reduced expression of mTOR downstream effectors at early treatment times, as we observe reduced eIF4G levels coupled with increased levels of eIF4E bound to 4E-BP, with consequential protein synthesis reduction. Severe combined immunodeficient mice injected with <span class="hlt">IBC</span> cells treated with Reishi for 13 weeks show reduced tumor growth and weight by ∼50%, and Reishi treated tumors showed reduced expression of E-cadherin, mTOR, eIF4G, and p70S6K, and activity of extracellular regulated kinase (ERK1/2). Our results provide evidence that Reishi suppresses protein synthesis and tumor growth by affecting survival and proliferative signaling pathways that act on translation, suggesting that Reishi is a potential natural therapeutic for breast and other cancers.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol6/pdf/CFR-2010-title49-vol6-sec451-14.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol6/pdf/CFR-2010-title49-vol6-sec451-14.pdf"><span>49 CFR 451.14 - Alternative approval of new containers by <span class="hlt">design</span> <span class="hlt">type</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>...) COAST GUARD, DEPARTMENT OF HOMELAND SECURITY SAFETY APPROVAL OF CARGO CONTAINERS TESTING AND APPROVAL OF CONTAINERS Approval of New Containers § 451.14 Alternative approval of new containers by <span class="hlt">design</span> <span class="hlt">type</span>. (a) New... 49 Transportation 6 2010-10-01 2010-10-01 false Alternative approval of new containers by <span class="hlt">design</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title49-vol6/pdf/CFR-2013-title49-vol6-sec451-14.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title49-vol6/pdf/CFR-2013-title49-vol6-sec451-14.pdf"><span>49 CFR 451.14 - Alternative approval of new containers by <span class="hlt">design</span> <span class="hlt">type</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-10-01</p> <p>...) COAST GUARD, DEPARTMENT OF HOMELAND SECURITY SAFETY APPROVAL OF CARGO CONTAINERS TESTING AND APPROVAL OF CONTAINERS Approval of New Containers § 451.14 Alternative approval of new containers by <span class="hlt">design</span> <span class="hlt">type</span>. (a) New... 49 Transportation 6 2013-10-01 2013-10-01 false Alternative approval of new containers by <span class="hlt">design</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title49-vol6/pdf/CFR-2012-title49-vol6-sec451-14.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title49-vol6/pdf/CFR-2012-title49-vol6-sec451-14.pdf"><span>49 CFR 451.14 - Alternative approval of new containers by <span class="hlt">design</span> <span class="hlt">type</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-10-01</p> <p>...) COAST GUARD, DEPARTMENT OF HOMELAND SECURITY SAFETY APPROVAL OF CARGO CONTAINERS TESTING AND APPROVAL OF CONTAINERS Approval of New Containers § 451.14 Alternative approval of new containers by <span class="hlt">design</span> <span class="hlt">type</span>. (a) New... 49 Transportation 6 2012-10-01 2012-10-01 false Alternative approval of new containers by <span class="hlt">design</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title49-vol6/pdf/CFR-2014-title49-vol6-sec451-14.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title49-vol6/pdf/CFR-2014-title49-vol6-sec451-14.pdf"><span>49 CFR 451.14 - Alternative approval of new containers by <span class="hlt">design</span> <span class="hlt">type</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-10-01</p> <p>...) COAST GUARD, DEPARTMENT OF HOMELAND SECURITY SAFETY APPROVAL OF CARGO CONTAINERS TESTING AND APPROVAL OF CONTAINERS Approval of New Containers § 451.14 Alternative approval of new containers by <span class="hlt">design</span> <span class="hlt">type</span>. (a) New... 49 Transportation 6 2014-10-01 2014-10-01 false Alternative approval of new containers by <span class="hlt">design</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title49-vol6/pdf/CFR-2011-title49-vol6-sec451-14.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title49-vol6/pdf/CFR-2011-title49-vol6-sec451-14.pdf"><span>49 CFR 451.14 - Alternative approval of new containers by <span class="hlt">design</span> <span class="hlt">type</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-10-01</p> <p>...) COAST GUARD, DEPARTMENT OF HOMELAND SECURITY SAFETY APPROVAL OF CARGO CONTAINERS TESTING AND APPROVAL OF CONTAINERS Approval of New Containers § 451.14 Alternative approval of new containers by <span class="hlt">design</span> <span class="hlt">type</span>. (a) New... 49 Transportation 6 2011-10-01 2011-10-01 false Alternative approval of new containers by <span class="hlt">design</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012PhPro..25..525W','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012PhPro..25..525W"><span>On Adaptive Extended Compatibility Changing <span class="hlt">Type</span> of Product <span class="hlt">Design</span> Strategy</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Wenwen, Jiang; Zhibin, Xie</p> <p></p> <p>The article uses research ways of Enterprise localization and enterprise's development course to research strategy of company's product <span class="hlt">design</span> and development. It announces at different stages for development, different kinds of enterprises will adopt product <span class="hlt">design</span> and development policies of different modes. It also announces close causality between development course of company and central technology and product. The result indicated enterprises in leading position in market, technology and brand adopt pioneer strategy <span class="hlt">type</span> of product research and development. These enterprise relying on the large-scale leading enterprise offering a complete set service adopts the passively duplicating <span class="hlt">type</span> tactic of product research and development. Some enterprise in part of advantage in technology, market, management or brand adopt following up strategy of product research and development. The enterprises with relative advantage position adopt the strategy of technology applied taking optimizing services as centre in product research and development in fields of brand culture and market service.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23202010','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23202010"><span>A finite-element simulation of galvanic coupling intra-body communication based on the whole human body.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Song, Yong; Zhang, Kai; Hao, Qun; Hu, Lanxin; Wang, Jingwen; Shang, Fuzhou</p> <p>2012-10-09</p> <p>Simulation based on the finite-element (FE) method plays an important role in the investigation of intra-body communication (<span class="hlt">IBC</span>). In this paper, a finite-element model of the whole body model used for the <span class="hlt">IBC</span> simulation is proposed and verified, while the FE simulation of the galvanic coupling <span class="hlt">IBC</span> with different signal transmission paths has been achieved. Firstly, a novel finite-element method for modeling the whole human body is proposed, and a FE model of the whole human body used for <span class="hlt">IBC</span> simulation was developed. Secondly, the simulations of the galvanic coupling <span class="hlt">IBC</span> with the different signal transmission paths were implemented. Finally, the feasibility of the proposed method was verified by using in vivo measurements within the frequency range of 10 kHz-5 MHz, whereby some important conclusions were deduced. Our results indicate that the proposed method will offer significant advantages in the investigation of the galvanic coupling intra-body communication.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3545581','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3545581"><span>A Finite-Element Simulation of Galvanic Coupling Intra-Body Communication Based on the Whole Human Body</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Song, Yong; Zhang, Kai; Hao, Qun; Hu, Lanxin; Wang, Jingwen; Shang, Fuzhou</p> <p>2012-01-01</p> <p>Simulation based on the finite-element (FE) method plays an important role in the investigation of intra-body communication (<span class="hlt">IBC</span>). In this paper, a finite-element model of the whole body model used for the <span class="hlt">IBC</span> simulation is proposed and verified, while the FE simulation of the galvanic coupling <span class="hlt">IBC</span> with different signal transmission paths has been achieved. Firstly, a novel finite-element method for modeling the whole human body is proposed, and a FE model of the whole human body used for <span class="hlt">IBC</span> simulation was developed. Secondly, the simulations of the galvanic coupling <span class="hlt">IBC</span> with the different signal transmission paths were implemented. Finally, the feasibility of the proposed method was verified by using in vivo measurements within the frequency range of 10 kHz–5 MHz, whereby some important conclusions were deduced. Our results indicate that the proposed method will offer significant advantages in the investigation of the galvanic coupling intra-body communication. PMID:23202010</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol2/pdf/CFR-2010-title49-vol2-sec173-466.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol2/pdf/CFR-2010-title49-vol2-sec173-466.pdf"><span>49 CFR 173.466 - Additional tests for <span class="hlt">Type</span> A packagings <span class="hlt">designed</span> for liquids and gases.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... for liquids and gases. 173.466 Section 173.466 Transportation Other Regulations Relating to...) Materials § 173.466 Additional tests for <span class="hlt">Type</span> A packagings <span class="hlt">designed</span> for liquids and gases. (a) In addition to the tests prescribed in § 173.465, <span class="hlt">Type</span> A packagings <span class="hlt">designed</span> for liquids and gases must be...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title49-vol2/pdf/CFR-2011-title49-vol2-sec173-466.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title49-vol2/pdf/CFR-2011-title49-vol2-sec173-466.pdf"><span>49 CFR 173.466 - Additional tests for <span class="hlt">Type</span> A packagings <span class="hlt">designed</span> for liquids and gases.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-10-01</p> <p>... for liquids and gases. 173.466 Section 173.466 Transportation Other Regulations Relating to...) Materials § 173.466 Additional tests for <span class="hlt">Type</span> A packagings <span class="hlt">designed</span> for liquids and gases. (a) In addition to the tests prescribed in § 173.465, <span class="hlt">Type</span> A packagings <span class="hlt">designed</span> for liquids and gases must be...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title49-vol2/pdf/CFR-2012-title49-vol2-sec173-466.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title49-vol2/pdf/CFR-2012-title49-vol2-sec173-466.pdf"><span>49 CFR 173.466 - Additional tests for <span class="hlt">Type</span> A packagings <span class="hlt">designed</span> for liquids and gases.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-10-01</p> <p>... for liquids and gases. 173.466 Section 173.466 Transportation Other Regulations Relating to...) Materials § 173.466 Additional tests for <span class="hlt">Type</span> A packagings <span class="hlt">designed</span> for liquids and gases. (a) In addition to the tests prescribed in § 173.465, <span class="hlt">Type</span> A packagings <span class="hlt">designed</span> for liquids and gases must be...</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li class="active"><span>12</span></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_12 --> <div id="page_13" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li class="active"><span>13</span></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="241"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title49-vol2/pdf/CFR-2013-title49-vol2-sec173-466.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title49-vol2/pdf/CFR-2013-title49-vol2-sec173-466.pdf"><span>49 CFR 173.466 - Additional tests for <span class="hlt">Type</span> A packagings <span class="hlt">designed</span> for liquids and gases.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-10-01</p> <p>... for liquids and gases. 173.466 Section 173.466 Transportation Other Regulations Relating to...) Materials § 173.466 Additional tests for <span class="hlt">Type</span> A packagings <span class="hlt">designed</span> for liquids and gases. (a) In addition to the tests prescribed in § 173.465, <span class="hlt">Type</span> A packagings <span class="hlt">designed</span> for liquids and gases must be...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title49-vol2/pdf/CFR-2014-title49-vol2-sec173-466.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title49-vol2/pdf/CFR-2014-title49-vol2-sec173-466.pdf"><span>49 CFR 173.466 - Additional tests for <span class="hlt">Type</span> A packagings <span class="hlt">designed</span> for liquids and gases.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-10-01</p> <p>... for liquids and gases. 173.466 Section 173.466 Transportation Other Regulations Relating to...) Materials § 173.466 Additional tests for <span class="hlt">Type</span> A packagings <span class="hlt">designed</span> for liquids and gases. (a) In addition to the tests prescribed in § 173.465, <span class="hlt">Type</span> A packagings <span class="hlt">designed</span> for liquids and gases must be...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28981649','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28981649"><span>Influence of Interval Between Postharvest Lettuce Residue Management and Subsequent Seeding of Broccoli on Cabbage Maggot (Diptera: Anthomyiidae) Infestation on Broccoli.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Joseph, Shimat V; Godfrey, Larry D; Bettiga, Christopher</p> <p>2017-10-01</p> <p>Larval stages of cabbage maggot, Delia radicum (L.) (Diptera: Anthomyiidae), attack the roots of Brassica crops and cause severe economic damage. In the Salinas Valley of California, Brassica crops are often planted after successive lettuce (Lactuca sativa L.) crops. The interval between postharvest soil incorporation of lettuce residue and the subsequent Brassica crop can be as short as 7 d, which could influence D. radicum infestation on broccoli (Brassica oleracea var. italica Plenck). In 2014 and 2015, the effect of intervals between crops (<span class="hlt">IBC</span>) on D. radicum infestation was evaluated. The treatments were 7, 20, 33, and 48 d <span class="hlt">IBC</span>, and NL (no lettuce), 7, 21, 36, and 49 d <span class="hlt">IBC</span> in 2014 and 2015, respectively. Insect counts and feeding damage on broccoli was assessed during 3-6 wk after planting. Adult Delia fly captures were significantly greater at 7 d than 36-49 d <span class="hlt">IBC</span> in both years. In both years, D. radicum eggs collected were significantly greater at 7 d than at 33 d or 36 d <span class="hlt">IBC</span> plots. Larvae collected were significantly greater at 7 d <span class="hlt">IBC</span> than all other treatments in 2014, but not in 2015. Similarly, severity of feeding injury was significantly greater in 7 d than 33 d or 48 d <span class="hlt">IBC</span> in 2014, but not in 2015. In 2015, broccoli with no prior lettuce had significantly lower Delia flies and D. radicum egg densities than 7 d or 21 d <span class="hlt">IBC</span>. The implication of these results as a cultural control tactic for D. radicum infestation is discussed. © The Author 2017. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016RScI...87k5114C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016RScI...87k5114C"><span><span class="hlt">Design</span> and characterization of a linear Hencken-<span class="hlt">type</span> burner</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Campbell, M. F.; Bohlin, G. A.; Schrader, P. E.; Bambha, R. P.; Kliewer, C. J.; Johansson, K. O.; Michelsen, H. A.</p> <p>2016-11-01</p> <p>We have <span class="hlt">designed</span> and constructed a Hencken-<span class="hlt">type</span> burner that produces a 38-mm-long linear laminar partially premixed co-flow diffusion flame. This burner was <span class="hlt">designed</span> to produce a linear flame for studies of soot chemistry, combining the benefit of the conventional Hencken burner's laminar flames with the advantage of the slot burner's geometry for optical measurements requiring a long interaction distance. It is suitable for measurements using optical imaging diagnostics, line-of-sight optical techniques, or off-axis optical-scattering methods requiring either a long or short path length through the flame. This paper presents details of the <span class="hlt">design</span> and operation of this new burner. We also provide characterization information for flames produced by this burner, including relative flow-field velocities obtained using hot-wire anemometry, temperatures along the centerline extracted using direct one-dimensional coherent Raman imaging, soot volume fractions along the centerline obtained using laser-induced incandescence and laser extinction, and transmission electron microscopy images of soot thermophoretically sampled from the flame.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2011AcA....61..179E','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2011AcA....61..179E"><span>Oxygen Issue in Core Collapse Supernovae</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Elmhamdi, A.</p> <p>2011-06-01</p> <p>We study the spectroscopic properties of a selected sample of 26 events within Core Collapse Supernovae (CCSNe) family. Special attention is paid to the nebular oxygen forbidden line [OI] 6300, 6364 Å doublet. We analyze the line flux ratio F6300/F6364 and infer information about the optical depth evolution, densities, volume-filling factors in the oxygen emitting zones. The line luminosity is measured for the sample events and its evolution is discussed on the basis of the bolometric light curve properties in <span class="hlt">type</span> II and in <span class="hlt">type</span> <span class="hlt">Ib-c</span> SNe. The luminosities are then translated into oxygen abundances using two different methods. The results are combined with the determined 56Ni masses and compared with theoretical models by means of the [O/Fe] vs. Mms diagram. Two distinguishable and continuous populations, corresponding to <span class="hlt">Ib-c</span> and <span class="hlt">type</span> II SNe, are found. The higher mass nature of the ejecta in <span class="hlt">type</span> II objects is also imprinted in the [CaII] 7291, 7324Å to [OI] 6300, 6364Å luminosity ratios. Our results may be used as input parameters for theoretical models studying the chemical enrichment of galaxies.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013SPIE.8652E..0GI','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013SPIE.8652E..0GI"><span>Color universal <span class="hlt">design</span>: analysis of color category dependency on color vision <span class="hlt">type</span> (4)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ikeda, Tomohiro; Ichihara, Yasuyo G.; Kojima, Natsuki; Tanaka, Hisaya; Ito, Kei</p> <p>2013-02-01</p> <p>This report is af ollow-up to SPIE-IS+T / Vol. 7528 7528051-8, SPIE-IS+T / Vol. 7866 78660J-1-8 and SPIE-IS+T / Vol. 8292 829206-1-8. Colors are used to communicate information in various situations, not just for <span class="hlt">design</span> and apparel. However, visual information given only by color may be perceived differently by individuals with different color vision <span class="hlt">types</span>. Human color vision is non-uniform and the variation in most cases is genetically linked to L-cones and M-cones. Therefore, color appearance is not the same for all color vision <span class="hlt">types</span>. Color Universal <span class="hlt">Design</span> is an easy-to-understand system that was created to convey color-coded information accurately to most people, taking color vision <span class="hlt">types</span> into consideration. In the present research, we studied trichromat (C-<span class="hlt">type</span>), prolan (P-<span class="hlt">type</span>), and deutan (D-<span class="hlt">type</span>) forms of color vision. We here report the result of two experiments. The first was the validation of the confusion colors using the color chart on CIELAB uniform color space. We made an experimental color chart (total of color cells is 622, the color difference between color cells is 2.5) for fhis experiment, and subjects have P-<span class="hlt">type</span> or D-<span class="hlt">type</span> color vision. From the data we were able to determine "the limits with high probability of confusion" and "the limits with possible confusion" around various basing points. The direction of the former matched with the theoretical confusion locus, but the range did not extend across the entire a* range. The latter formed a belt-like zone above and below the theoretical confusion locus. This way we re-analyzed a part of the theoretical confusion locus suggested by Pitt-Judd. The second was an experiment in color classification of the subjects with C-<span class="hlt">type</span>, P-<span class="hlt">type</span>, or D-<span class="hlt">type</span> color vision. The color caps of fhe 100 Hue Test were classified into seven categories for each color vision <span class="hlt">type</span>. The common and different points of color sensation were compared for each color vision <span class="hlt">type</span>, and we were able to find a group of color caps</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23388622','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23388622"><span>WikiLeaks and Iraq Body Count: the sum of parts may not add up to the whole-a comparison of two tallies of Iraqi civilian deaths.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Carpenter, Dustin; Fuller, Tova; Roberts, Les</p> <p>2013-06-01</p> <p>Introduction The number of civilians killed in Iraq following the 2003 invasion has proven difficult to measure and contentious in recent years. The release of the Wikileaks War Logs (WL) has created the potential to conduct a sensitivity analysis of the commonly-cited Iraq Body Count's (<span class="hlt">IBC</span>'s) tally, which is based on press, government, and other public sources. Hypothesis The 66,000 deaths reported in the Wikileaks War Logs are mostly the same events as those previously reported in the press and elsewhere as tallied by iraqbodycount.org. A systematic random sample of 2500 violent fatal War Log incidents was selected and evaluated to determine whether these incidents were also found in <span class="hlt">IBC</span>'s press-based listing. Each selected event was ranked on a scale of 0 (no match present) to 3 (almost certainly matched) with regard to the likelihood it was listed in the <span class="hlt">IBC</span> database. Of the two thousand four hundred and nine War Log records, 488 (23.8%) were found to have likely matches in <span class="hlt">IBC</span> records. Events that killed more people were far more likely to appear in both datasets, with 94.1% of events in which ≥20 people were killed being likely matches, as compared with 17.4% of singleton killings. Because of this skew towards the recording of large events in both datasets, it is estimated that 2035 (46.3%) of the 4394 deaths reported in the Wikileaks War Logs had been previously reported in <span class="hlt">IBC</span>. Passive surveillance systems, widely seen as incomplete, may also be selective in the <span class="hlt">types</span> of events detected in times of armed conflict. Bombings and other events during which many people are killed, and events in less violent areas, appear to be detected far more often, creating a skewed image of the mortality profile in Iraq. Members of the press and researchers should be hesitant to draw conclusions about the nature or extent of violence from passive surveillance systems of low or unknown sensitivity.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26187736','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26187736"><span>A Bayesian sequential <span class="hlt">design</span> using alpha spending function to control <span class="hlt">type</span> I error.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Zhu, Han; Yu, Qingzhao</p> <p>2017-10-01</p> <p>We propose in this article a Bayesian sequential <span class="hlt">design</span> using alpha spending functions to control the overall <span class="hlt">type</span> I error in phase III clinical trials. We provide algorithms to calculate critical values, power, and sample sizes for the proposed <span class="hlt">design</span>. Sensitivity analysis is implemented to check the effects from different prior distributions, and conservative priors are recommended. We compare the power and actual sample sizes of the proposed Bayesian sequential <span class="hlt">design</span> with different alpha spending functions through simulations. We also compare the power of the proposed method with frequentist sequential <span class="hlt">design</span> using the same alpha spending function. Simulations show that, at the same sample size, the proposed method provides larger power than the corresponding frequentist sequential <span class="hlt">design</span>. It also has larger power than traditional Bayesian sequential <span class="hlt">design</span> which sets equal critical values for all interim analyses. When compared with other alpha spending functions, O'Brien-Fleming alpha spending function has the largest power and is the most conservative in terms that at the same sample size, the null hypothesis is the least likely to be rejected at early stage of clinical trials. And finally, we show that adding a step of stop for futility in the Bayesian sequential <span class="hlt">design</span> can reduce the overall <span class="hlt">type</span> I error and reduce the actual sample sizes.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017ChOE...31..567M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017ChOE...31..567M"><span>Concept <span class="hlt">design</span> and coupled dynamic response analysis on 6-MW spar-<span class="hlt">type</span> floating offshore wind turbine</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Meng, Long; Zhou, Tao; He, Yan-ping; Zhao, Yong-sheng; Liu, Ya-dong</p> <p>2017-10-01</p> <p>Tower, Spar platform and mooring system are <span class="hlt">designed</span> in the project based on a given 6-MW wind turbine. Under wind-induced only, wave-induced only and combined wind and wave induced loads, dynamic response is analyzed for a 6-MW Spar-<span class="hlt">type</span> floating offshore wind turbine (FOWT) under operating conditions and parked conditions respectively. Comparison with a platform-fixed system (land-based system) of a 6-MW wind turbine is carried out as well. Results demonstrate that the maximal out-of-plane deflection of the blade of a Spar-<span class="hlt">type</span> system is 3.1% larger than that of a land-based system; the maximum response value of the nacelle acceleration is 215% larger for all the <span class="hlt">designed</span> load cases being considered; the ultimate tower base fore-aft bending moment of the Spar-<span class="hlt">type</span> system is 92% larger than that of the land-based system in all of the <span class="hlt">Design</span> Load Cases (DLCs) being considered; the fluctuations of the mooring tension is mainly wave-induced, and the safety factor of the mooring tension is adequate for the 6-MW FOWT. The results can provide relevant modifications to the initial <span class="hlt">design</span> for the Spar-<span class="hlt">type</span> system, the detailed <span class="hlt">design</span> and model basin test of the 6-MW Spar-<span class="hlt">type</span> system.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20020015984&hterms=Friedrichshafen&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3DFriedrichshafen','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20020015984&hterms=Friedrichshafen&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3DFriedrichshafen"><span>Reduction of Helicopter BVI Noise, Vibration, and Power Consumption Through Individual Blade Control</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Jacklin, Stephen A.; Blaas, Achim; Teves, Dietrich; Kube, Roland; Warmbrodt, William (Technical Monitor)</p> <p>1994-01-01</p> <p>A wind tunnel test was conducted with a full-scale BO 105 helicopter rotor to evaluate the potential of open-loop individual blade control (<span class="hlt">IBC</span>) to improve rotor performance, to reduce blade vortex interaction (BVI) noise, and to alleviate helicopter vibrations. The wind tunnel test was an international collaborative effort between NASA/U.S. Army AFDD, ZF Luftfahrttechnik, Eurocopter Deutschland, and the German Aerospace Laboratory (DLR) and was conducted under the auspices of the U.S./German MOU on Rotorcraft Aeromechanics. In this test the normal blade pitch links of the rotor were replaced by servo-actuators so that the pitch of each blade could be controlled independently of the other blades. The specially <span class="hlt">designed</span> servoactuators and <span class="hlt">IBC</span> control system were <span class="hlt">designed</span> and manufactured by ZF Luftfahrttechnik, GmbH. The wind tunnel test was conducted in the 40- by 80-Foot Wind Tunnel at the NASA Ames Research Center. An extensive amount of measurement information was acquired for each <span class="hlt">IBC</span> data point. These data include rotor performance, static and dynamic hub forces and moments, rotor loads, control loads, inboard and outboard blade pitch motion, and BVI noise data. The data indicated very significant (80 percent) simultaneous reductions in both BVI noise and hub vibrations could be obtained using multi-harmonic input at the critical descent (terminal approach) condition. The data also showed that performance improvements of up to 7 percent could be obtained using 2P input at high-speed forward flight conditions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016cosp...41E1134L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016cosp...41E1134L"><span>New <span class="hlt">design</span> of a passive <span class="hlt">type</span> RADFET reader for enhanced sensitivity</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Lee, Dae-Hee</p> <p>2016-07-01</p> <p>We present a new <span class="hlt">design</span> of a passive <span class="hlt">type</span> RADFET reader with enhanced radiation sensitivity. Using a electostatic plate, we have applied a static electric field to the gate voltage, which impacts a positive biasing on the p-<span class="hlt">type</span> MOSFET. The resultant effect shows that 1.8 times of radiation sensitivity increased when we measured the threshold voltage shift of the RADFET exposed to 30 krad irradiation. We discuss further about the characteristic changes of a RADFET according to the positive biasing on the gate voltage.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25076185','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25076185"><span>Comparison of a classical with a highly formularized body condition scoring system for dairy cattle.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Isensee, A; Leiber, F; Bieber, A; Spengler, A; Ivemeyer, S; Maurer, V; Klocke, P</p> <p>2014-12-01</p> <p>Body condition scoring is a common tool to assess the subcutaneous fat reserves of dairy cows. Because of its subjectivity, which causes limits in repeatability, it is often discussed controversially. Aim of the current study was to evaluate the impact of considering the cows overall appearance on the scoring process and on the validity of the results. Therefore, two different methods to reveal body condition scores (BCS), 'independent BCS' (<span class="hlt">iBCS</span>) and 'dependent BCS' (dBCS), were used to assess 1111 Swiss Brown Cattle. The <span class="hlt">iBCS</span> and the dBCS systems were both working with the same flowchart with a decision tree structure for visual and palpatory assessment using a scale from 2 to 5 with increment units of 0.25. The <span class="hlt">iBCS</span> was created strictly complying with the defined frames of the decision tree structure. The system was chosen due to its formularized approach to reduce the influence of subjective impressions. By contrast, the dBCS system, which was in line with common practice, had a more open approach, where - besides the decision tree - the overall impression of the cow's physical appearance was taken into account for generating the final score. Ultrasound measurement of the back fat thickness (BFT) was applied as a validation method. The dBCS turned out to be the better predictor of BFT, explaining 67.3% of the variance. The <span class="hlt">iBCS</span> was only able to explain 47.3% of the BFT variance. Within the whole data set, only 31.3% of the animals received identical dBCS and <span class="hlt">iBCS</span>. The pin bone region caused the most deviations between dBCS and <span class="hlt">iBCS</span>, but also assessing the pelvis line, the hook bones and the ligaments led to divergences in around 20% of the scored animals. The study showed that during the assessment of body condition a strict adherence to a decision tree is a possible source of inexact classifications. Some body regions, especially the pin bones, proved to be particularly challenging for scoring due to difficulties in assessing them. All the more, the inclusion</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=international+AND+branch+AND+campuse&pg=2&id=EJ1098819','ERIC'); return false;" href="https://eric.ed.gov/?q=international+AND+branch+AND+campuse&pg=2&id=EJ1098819"><span>The Role of Institutional Dual Embeddedness in the Strategic Local Adaptation of International Branch Campuses: Evidence from Malaysia and Singapore</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Shams, Farshid; Huisman, Jeroen</p> <p>2016-01-01</p> <p>Past research revealed that International Branch Campuses (<span class="hlt">IBCs</span>) are simultaneously under two <span class="hlt">types</span> of isomorphic pressures. On the one hand, they are obliged to conform to the institutions of their host countries, which lead them towards homogenising with the local Higher Education Institutions (HEIs), hence deviate from their parent unit's…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21888505','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21888505"><span>Ganoderma lucidum (Reishi) inhibits cancer cell growth and expression of key molecules in inflammatory breast cancer.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Martínez-Montemayor, Michelle M; Acevedo, Raysa Rosario; Otero-Franqui, Elisa; Cubano, Luis A; Dharmawardhane, Suranganie F</p> <p>2011-01-01</p> <p>Inflammatory breast cancer (<span class="hlt">IBC</span>) is the most lethal and least understood form of advanced breast cancer. Its lethality originates from its nature of invading the lymphatic system and absence of a palpable tumor mass. Different from other metastatic breast cancer cells, <span class="hlt">IBC</span> cells invade by forming tumor spheroids that retain E-cadherin-based cell-cell adhesions. Herein we describe the potential of the medicinal mushroom Ganoderma lucidum (Reishi) as an attractive candidate for anti-<span class="hlt">IBC</span> therapy. Reishi contains biological compounds that are cytotoxic against cancer cells. We report the effects of Reishi on viability, apoptosis, invasion, and its mechanism of action in <span class="hlt">IBC</span> cells (SUM-149). Results show that Reishi selectively inhibits cancer cell viability although it does not affect the viability of noncancerous mammary epithelial cells. Apoptosis induction is consistent with decreased cell viability. Reishi inhibits cell invasion and disrupts the cell spheroids that are characteristic of the <span class="hlt">IBC</span> invasive pathology. Reishi decreases the expression of genes involved in cancer cell survival and proliferation (BCL-2, TERT, PDGFB), and invasion and metastasis (MMP-9), whereas it increases the expression of IL8. Reishi reduces BCL-2, BCL-XL, E-cadherin, eIF4G, p120-catenin, and c-Myc protein expression and gelatinase activity. These findings suggest that Reishi is an effective anti-<span class="hlt">IBC</span> therapeutic.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3201987','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3201987"><span>Ganoderma lucidum (Reishi) Inhibits Cancer Cell Growth and Expression of Key Molecules in Inflammatory Breast Cancer</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Martínez-Montemayor, Michelle M.; Acevedo, Raysa Rosario; Otero-Franqui, Elisa; Cubano, Luis. A.; Dharmawardhane, Suranganie F.</p> <p>2011-01-01</p> <p>Inflammatory breast cancer (<span class="hlt">IBC</span>) is the most lethal and least understood form of advanced breast cancer. Its lethality originates from its nature of invading the lymphatic system and absence of a palpable tumor mass. Different from other metastatic breast cancer cells, <span class="hlt">IBC</span> cells invade by forming tumor spheroids that retain E-cadherin-based cell–cell adhesions. Herein we describe the potential of the medicinal mushroom Ganoderma lucidum (Reishi) as an attractive candidate for anti-<span class="hlt">IBC</span> therapy. Reishi contains biological compounds that are cytotoxic against cancer cells. We report the effects of Reishi on viability, apoptosis, invasion, and its mechanism of action in <span class="hlt">IBC</span> cells (SUM-149). Results show that Reishi selectively inhibits cancer cell viability although it does not affect the viability of noncancerous mammary epithelial cells. Apoptosis induction is consistent with decreased cell viability. Reishi inhibits cell invasion and disrupts the cell spheroids that are characteristic of the <span class="hlt">IBC</span> invasive pathology. Reishi decreases the expression of genes involved in cancer cell survival and proliferation (BCL-2, TERT, PDGFB), and invasion and metastasis (MMP-9), whereas it increases the expression of IL8. Reishi reduces BCL-2, BCL-XL, E-cadherin, eIF4G, p120-catenin, and c-Myc protein expression and gelatinase activity. These findings suggest that Reishi is an effective anti-<span class="hlt">IBC</span> therapeutic. PMID:21888505</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19740003570','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19740003570"><span>Development of low-shock pyrotechnic separation nuts. [<span class="hlt">design</span> performance of flight <span class="hlt">type</span> nuts</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Bement, L. J.; Neubert, V. H.</p> <p>1973-01-01</p> <p>Performance demonstrations and comparisons were made on six flight <span class="hlt">type</span> pyrotechnic separation nut <span class="hlt">designs</span>, two of which are standard <span class="hlt">designs</span> in current use, and four of which were <span class="hlt">designed</span> to produce low shock on actuation. Although the shock performances of the four low shock <span class="hlt">designs</span> are considerably lower than the standard <span class="hlt">designs</span>, some penalties may be incurred in increased volume, weight, or complexity. These nuts, and how they are installed, can significantly influence the pyrotechnic shock created in spacecraft structures. A high response monitoring system has been developed and demonstrated to provide accurate performance comparisons for pyrotechnic separation nuts.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016ChOE...30..581W','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016ChOE...30..581W"><span>Connection technology of HPTO <span class="hlt">type</span> WECs and DC nano grid in island</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Wang, Kun-lin; Tian, Lian-fang; You, Ya-ge; Wang, Xiao-hong; Sheng, Song-wei; Zhang, Ya-qun; Ye, Yin</p> <p>2016-07-01</p> <p>Wave energy fluctuating a great deal endangers the security of power grid especially micro grid in island. A DC nano grid supported by batteries is proposed to smooth the output power of wave energy converters (WECs). Thus, renewable energy converters connected to DC grid is a new subject. The characteristics of WECs are very important to the connection technology of HPTO <span class="hlt">type</span> WECs and DC nano grid. Hydraulic power take-off system (HPTO) is the core unit of the largest category of WECs, with the functions of supplying suitable damping for a WEC to absorb wave energy, and converting captured wave energy to electricity. The HPTO is divided into a hydraulic energy storage system (HESS) and a hydraulic power generation system (HPGS). A primary numerical model for the HPGS is established in this paper. Three important basic characteristics of the HPGS are deduced, which reveal how the generator load determines the HPGS rotation rate. Therefore, the connector of HPTO <span class="hlt">type</span> WEC and DC nano grid would be an uncontrollable rectifier with high reliability, also would be a controllable power converter with high efficiency, such as interleaved boost converter-<span class="hlt">IBC</span>. The research shows that it is very flexible to connect to DC nano grid for WECs, but bypass resistance loads are indispensable for the security of WECs.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22648738-disparities-use-postmastectomy-radiation-therapy-inflammatory-breastcancer','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22648738-disparities-use-postmastectomy-radiation-therapy-inflammatory-breastcancer"><span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Loveland-Jones, Catherine; Lin, Heather; Shen, Yu</p> <p></p> <p>Purpose: Although radiation therapy improves locoregional control and survival for inflammatory breast cancer (<span class="hlt">IBC</span>), it is underused in this population. The purpose of this study was to identify variables associated with the underuse of postmastectomy radiation therapy (PMRT) for <span class="hlt">IBC</span>. Methods and Materials: Using the 1998 to 2011 National Cancer Data Base, we identified 8273 women who underwent mastectomy for nonmetastatic <span class="hlt">IBC</span>. We used logistic regression modeling to determine the demographic, tumor, and treatment variables associated with the underuse of PMRT. Results: Although the use of PMRT increased over time, a total of 30.3% of our cohort did not receivemore » PMRT. On multivariate analysis, variables associated with the underuse of PMRT for <span class="hlt">IBC</span> included the following (all P<.05): Medicare insurance (odds ratio [OR] = 0.70), annual income <$34,999 (<$30,000: OR=0.79; $30,000-$34,999: OR=0.82), cN2 and cN0 disease (cN2: OR=0.71; cN0: OR=0.63), failure to receive chemotherapy and hormone therapy (chemotherapy: OR=0.15; hormone therapy: OR=0.35), treatment at lower-volume centers (OR=0.83), and treatment in the South and West (South: OR=0.73; West: OR=0.80). Greater distance between patient's residence and radiation facility was also associated with the underuse of PMRT (P=.0001). Conclusions: Although the use of PMRT for <span class="hlt">IBC</span> has increased over time, it continues to be underused. Disparities related to a variety of variables impact which <span class="hlt">IBC</span> patients receive PMRT. A concerted effort must be made to address these disparities in order to optimize the outcomes for <span class="hlt">IBC</span>.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25895501','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25895501"><span>Structural Biology Insight for the <span class="hlt">Design</span> of Sub-<span class="hlt">type</span> Selective Aurora Kinase Inhibitors.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Sarvagalla, Sailu; Coumar, Mohane Selvaraj</p> <p>2015-01-01</p> <p>Aurora kinase A, B and C, are key regulators of mitosis and are over expressed in many of the human cancers, making them an ideal drug target for cancer chemotherapy. Currently, over a dozen of Aurora kinase inhibitors are in various phases of clinical development. The majority of the inhibitors (VX-680/MK-0457, PHA-739358, CYC116, SNS-314, AMG 900, AT-9283, SCH- 1473759, ABT-348, PF-03814735, R-763/AS-703569, KW-2449 and TAK-901) are pan-selective (isoform non-selective) and few are Aurora A (MLN8054, MLN8237, VX-689/MK5108 and ENMD 2076) and Aurora B (AZD1152 and GSK1070916) sub-<span class="hlt">type</span> selective. Despite the intensive research efforts in the past decade, no Aurora kinase inhibitor has reached the market. Recent evidence suggests that the sub-<span class="hlt">type</span> selective Aurora kinase A inhibitor could possess advantages over pan-selective Aurora inhibitors, by avoiding Aurora B mediated neutropenia. However, sub-<span class="hlt">type</span> selective Aurora kinase A inhibitor <span class="hlt">design</span> is very challenging due to the similarity in the active site among the isoforms. Structural biology and computational aspects pertaining to the <span class="hlt">design</span> of Aurora kinase inhibitors were analyzed and found that a possible means to develop sub-<span class="hlt">type</span> selective inhibitor is by targeting Aurora A specific residues (Leu215, Thr217 and Arg220) or Aurora B specific residues (Arg159, Glu161 and Lys164), near the solvent exposed region of the protein. Particularly, a useful strategy for the <span class="hlt">design</span> of sub-<span class="hlt">type</span> selective Aurora A inhibitor could be by targeting Thr217 residue as in the case of MLN8054. Further preclinical and clinical studies with the sub-<span class="hlt">type</span> selective Aurora inhibitors could help bring them to the market for the treatment of cancer.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24669011','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24669011"><span>Survival of women with inflammatory breast cancer: a large population-based study.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Dawood, S; Lei, X; Dent, R; Gupta, S; Sirohi, B; Cortes, J; Cristofanilli, M; Buchholz, T; Gonzalez-Angulo, A M</p> <p>2014-06-01</p> <p>Our group has previously reported that women with inflammatory breast cancer (<span class="hlt">IBC</span>) continue to have worse outcome compared with those with non-<span class="hlt">IBC</span>. We undertook this population-based study to see if there have been improvements in survival among women with stage III <span class="hlt">IBC</span>, over time. We searched the Surveillance, Epidemiology and End Results Registry to identify female patients diagnosed with stage III <span class="hlt">IBC</span> between 1990 and 2010. Patients were divided into four groups according to year of diagnosis: 1990-1995, 1996-2000, 2001-2005, and 2006-2010. Breast cancer-specific survival (BCSS) was estimated using the Kaplan-Meier method and compared across groups using the log-rank test. Cox models were then fit to determine the association of year of diagnosis and BCSS after adjusting for patient and tumor characteristics. A total of 7679 patients with <span class="hlt">IBC</span> were identified of whom 1084 patients (14.1%) were diagnosed between 1990 and 1995, 1614 patients (21.0%) between 1996 and 2000, 2683 patients (34.9%) between 2001 and 2005, and 2298 patients (29.9%) between 2006 and 2010. The 2-year BCSS for the whole cohort was 71%. Two-year BCSS were 62%, 67%, 72%, and 76% for patients diagnosed between 1990-1995, 1996-2000, 2001-2005, and 2006-2010, respectively (P < 0.0001). In the multivariable analysis, increasing year of diagnosis (modeled as a continuous variable) was associated with decreasing risks of death from breast cancer (HR = 0.98, 95% confidence interval 0.97-0.99, P < 0.0001). There has been a significant improvement in survival of patients diagnosed with <span class="hlt">IBC</span> over a two-decade time span in this large population-based study. This suggests that therapeutic strategies researched and evolved in the context of non-<span class="hlt">IBC</span> have also had a positive impact in women with <span class="hlt">IBC</span>. © The Author 2014. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li class="active"><span>13</span></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_13 --> <div id="page_14" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li class="active"><span>14</span></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="261"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4476726','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4476726"><span>Positive Association of Fibroadenomatoid Change with HER2-Negative Invasive Breast Cancer: A Co-Occurrence Study</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Kovatich, Albert J.; Hooke, Jeffrey A.; Liu, Jianfang; Kvecher, Leonid; Fantacone-Campbell, J. Leigh; Mitchell, Edith P.; Rui, Hallgeir; Shriver, Craig D.; Hu, Hai</p> <p>2015-01-01</p> <p>Background Risk assessment of a benign breast disease/lesion (BBD) for invasive breast cancer (<span class="hlt">IBC</span>) is typically done through a longitudinal study. For an infrequently-reported BBD, the shortage of occurrence data alone is a limiting factor to conducting such a study. Here we present an approach based on co-occurrence analysis, to help address this issue. We focus on fibroadenomatoid change (FAC), an under-studied BBD, as our preliminary analysis has suggested its previously unknown significant co-occurrence with <span class="hlt">IBC</span>. Methods A cohort of 1667 female patients enrolled in the Clinical Breast Care Project was identified. A single experienced breast pathologist reviewed all pathology slides for each case and recorded all observed lesions, including FAC. Fibroadenoma (FA) was studied for comparison since FAC had been speculated to be an immature FA. FA and Fibrocystic Changes (FCC) were used for method validation since they have been comprehensively studied. Six common <span class="hlt">IBC</span> and BBD risk/protective factors were also studied. Co-occurrence analyses were performed using logistic regression models. Results Common risk/protective factors were associated with FA, FCC, and <span class="hlt">IBC</span> in ways consistent with the literature in general, and they were associated with FAC, FA, and FCC in distinct patterns. Age was associated with FAC in a bell-shape curve so that middle-aged women were more likely to have FAC. We report for the first time that FAC is positively associated with <span class="hlt">IBC</span> with odds ratio (OR) depending on BMI (OR = 6.78, 95%CI = 3.43-13.42 at BMI<25 kg/m2; OR = 2.13, 95%CI = 1.20-3.80 at BMI>25 kg/m2). This association is only significant with HER2-negative <span class="hlt">IBC</span> subtypes. Conclusions We conclude that FAC is a candidate risk factor for HER2-negative <span class="hlt">IBCs</span>, and it is a distinct disease from FA. Co-occurrence analysis can be used for initial assessment of the risk for <span class="hlt">IBC</span> from a BBD, which is vital to the study of infrequently-reported BBDs. PMID:26098961</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22597188-design-development-line-type-modulators-high-impedance-electron-gun','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22597188-design-development-line-type-modulators-high-impedance-electron-gun"><span><span class="hlt">Design</span> and development of line <span class="hlt">type</span> modulators for high impedance electron gun</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Dixit, Kavita P.; Tillu, Abhijit; Chavan, Ramchandra</p> <p></p> <p>Conventional line <span class="hlt">type</span> modulators are routinely used for powering pulsed power microwave devices such as magnetrons and klystrons used for radar, medical and scientific applications. The load impedance (operating point) is fairly well defined in these cases, and makes the <span class="hlt">design</span> of the discharging circuit of the modulator straight forward. This paper describes the Line <span class="hlt">type</span> modulators that have been developed and being routinely used for powering the Triode Electron Gun of industrial electron linacs. The beam parameters of such guns are user defined and the pulse current varies from few mA to 800mA (typ). The beam energies requirement variesmore » from 40 keV to 80 keV. Hence the impedance offered by the electron gun to the power source (modulator) is not well defined. The load capacitance which is inclusive of the various stray capacitances along with the intrinsic gun capacitance is ∼ 200-400 pF. This capacitance, which depends on the configuration, shunts the load and makes the effective load highly capacitive with the resistive part varying over a wide range. The paper describes the <span class="hlt">design</span> and development of conventional line <span class="hlt">type</span> modulators for powering Electron gun load of the <span class="hlt">type</span> described above. (author)« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/15702608','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/15702608"><span><span class="hlt">Type</span> I error probabilities based on <span class="hlt">design</span>-stage strategies with applications to noninferiority trials.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Rothmann, Mark</p> <p>2005-01-01</p> <p>When testing the equality of means from two different populations, a t-test or large sample normal test tend to be performed. For these tests, when the sample size or <span class="hlt">design</span> for the second sample is dependent on the results of the first sample, the <span class="hlt">type</span> I error probability is altered for each specific possibility in the null hypothesis. We will examine the impact on the <span class="hlt">type</span> I error probabilities for two confidence interval procedures and procedures using test statistics when the <span class="hlt">design</span> for the second sample or experiment is dependent on the results from the first sample or experiment (or series of experiments). Ways for controlling a desired maximum <span class="hlt">type</span> I error probability or a desired <span class="hlt">type</span> I error rate will be discussed. Results are applied to the setting of noninferiority comparisons in active controlled trials where the use of a placebo is unethical.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018AIPC.1967c0036Z','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018AIPC.1967c0036Z"><span><span class="hlt">Design</span> of a new <span class="hlt">type</span> synchronous focusing mechanism</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Zhang, Jintao; Tan, Ruijun; Chen, Zhou; Zhang, Yongqi; Fu, Panlong; Qu, Yachen</p> <p>2018-05-01</p> <p>Aiming at the dual channel telescopic imaging system composed of infrared imaging system, low-light-level imaging system and image fusion module, In the fusion of low-light-level images and infrared images, it is obvious that using clear source images is easier to obtain high definition fused images. When the target is imaged at 15m to infinity, focusing is needed to ensure the imaging quality of the dual channel imaging system; therefore, a new <span class="hlt">type</span> of synchronous focusing mechanism is <span class="hlt">designed</span>. The synchronous focusing mechanism realizes the focusing function through the synchronous translational imaging devices, mainly including the structure of the screw rod nut, the shaft hole coordination structure and the spring steel ball eliminating clearance structure, etc. Starting from the synchronous focusing function of two imaging devices, the structure characteristics of the synchronous focusing mechanism are introduced in detail, and the focusing range is analyzed. The experimental results show that the synchronous focusing mechanism has the advantages of ingenious <span class="hlt">design</span>, high focusing accuracy and stable and reliable operation.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=benefit+AND+decision+AND+making&pg=4&id=ED580543','ERIC'); return false;" href="https://eric.ed.gov/?q=benefit+AND+decision+AND+making&pg=4&id=ED580543"><span>Establishment of an Internationally Based Offshore Branch Campus: An Australian Case Study</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Wood, Raynie L.</p> <p>2017-01-01</p> <p>As a result of the changes in society due to globalization, higher-education organizations are working to prepare graduates for a more global workplace. One of the methods of transnational education recognized for providing access to a global education is the international branch campus (<span class="hlt">IBC</span>). While there are various <span class="hlt">types</span> of international…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/6362253-bitter-type-magnet-plate-design-compound-conductor-ultrahigh-mechanical-strength','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/6362253-bitter-type-magnet-plate-design-compound-conductor-ultrahigh-mechanical-strength"><span>Bitter-<span class="hlt">type</span> magnet plate <span class="hlt">design</span> with compound conductor of ultrahigh mechanical strength</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Haubenberger, W.D.</p> <p>1981-01-01</p> <p>A Bitter-<span class="hlt">type</span> magnet plate <span class="hlt">design</span> based on a compound conductor of ultrahigh mechanical strength is described. An explosion-bonded and cold-worked copper-austenite compound is jointed by a special procedure with a soft compound sheet.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016PlPhR..42.1106H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016PlPhR..42.1106H"><span><span class="hlt">Design</span> of a 500-kJ Mather-<span class="hlt">type</span> plasma focus device</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Heidarnia, A.; Sadighzadeh, A.; Zaeem, A. A.; Damideh, V.</p> <p>2016-12-01</p> <p>In this article, <span class="hlt">design</span> of a 500-kJ Mather-<span class="hlt">type</span> plasma focus device to achieve 1011 neutrons/shot is reported. One of its important characteristics is the triple-part anode <span class="hlt">design</span>. The anode is surrounded by an alumina insulator. The second part of the anode is changeable in order to locate cylindrical, conical, or other shapes of pieces mounted on it. This geometry leads to the easier investigation of the neutron and X-ray emissions of the device. The third part of the anode is for changing the materials exposed to different kinds of radiations. The <span class="hlt">design</span> parameters are considered by semiempirical and empirical formulas and are sketched by Solidworks software. Also, the peak current and neutron yield are estimated.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.nrel.gov/news/program/2014/15428.html','SCIGOVWS'); return false;" href="https://www.nrel.gov/news/program/2014/15428.html"><span>Innovative Way to Test Batteries Fills a Market Niche | News | NREL</span></a></p> <p><a target="_blank" href="http://www.science.gov/aboutsearch.html">Science.gov Websites</a></p> <p></p> <p></p> <p>researchers, performs precise <em>thermal</em> measurements needed to <span class="hlt">design</span> safer, longer-lasting, and more cost NREL researchers, are capable of performing the precise <em>thermal</em> measurements needed to make safer . Batteries cannot survive heat, and they need <em>thermal</em> management; <span class="hlt">IBCs</span> are essential in measuring how much</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015AIPC.1700e0006O','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015AIPC.1700e0006O"><span><span class="hlt">Design</span> and analysis of permanent magnet moving coil <span class="hlt">type</span> generator used in a micro-CHP generation system</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Oros Pop, Susana Teodora; Berinde, Ioan; Vadan, Ioan</p> <p>2015-12-01</p> <p>This paper presents the <span class="hlt">design</span> and analysis of a permanent magnet moving coil <span class="hlt">type</span> generator driven by a free piston Stirling engine. This assemble free piston Stirling engine - permanent magnet moving coil <span class="hlt">type</span> generator will be used in a combined heat and power (CHP) system for producing heat and power in residential area. The <span class="hlt">design</span> procedure for moving coil <span class="hlt">type</span> linear generator starts from the rated power imposed and finally uses the Faraday law of induction. The magneto-static magnetic field generated by permanent magnets is analyzed by means of Reluctance method and Finite Element Method in order to evaluate the magnetic flux density in the air gap, which is a <span class="hlt">design</span> data imposed in the <span class="hlt">design</span> stage, and the results are compared.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015ATel.8039....1T','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015ATel.8039....1T"><span>Asiago spectroscopic classification of PSN J02051332+0606084 as <span class="hlt">Type</span> <span class="hlt">Ib/c</span> supernova</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Tartaglia, L.; Elias-Rosa, N.; Benetti, S.; Cappellaro, E.; Tomasella, L.; Ochner, P.; Pastorello, A.; Terreran, G.; Turatto, M.</p> <p>2015-09-01</p> <p>The Asiago Transient Classification Program (Tomasella et al. 2014, AN, 335, 841) reports the spectroscopic classification of PSN J02051332+0606084. Informations on this transient are also available from the "Bright Supernova" website (http://www.rochesterastronomy.org/snimages/), and the CBAT Transient Object Followup Reports (http://www.cbat.eps.harvard.edu/index.html).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19730022286','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19730022286"><span>Development of system <span class="hlt">design</span> information for carbon dioxide using an amine <span class="hlt">type</span> sorber</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Rankin, R. L.; Roehlich, F.; Vancheri, F.</p> <p>1971-01-01</p> <p>Development work on system <span class="hlt">design</span> information for amine <span class="hlt">type</span> carbon dioxide sorber is reported. Amberlite IR-45, an aminated styrene divinyl benzene matrix, was investigated to determine the influence of <span class="hlt">design</span> parameters of sorber particle size, process flow rate, CO2 partial pressure, total pressure, and bed <span class="hlt">designs</span>. CO2 capacity and energy requirements for a 4-man size system were related mathematically to important operational parameters. Some fundamental studies in CO2 sorber capacity, energy requirements, and process operation were also performed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013MNRAS.428.1927C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013MNRAS.428.1927C"><span>On the association between core-collapse supernovae and H ii regions</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Crowther, Paul A.</p> <p>2013-01-01</p> <p>Previous studies of the location of core-collapse supernovae (ccSNe) in their host galaxies have variously claimed an association with H ii regions; no association or an association only with hydrogen-deficient ccSNe. Here, we examine the immediate environments of 39 ccSNe whose positions are well known in nearby (≤15 Mpc), low-inclination (≤65°) hosts using mostly archival, continuum-subtracted Hα ground-based imaging. We find that 11 out of 29 hydrogen-rich ccSNe are spatially associated with H ii regions (38 ± 11 per cent), versus 7 out of 10 hydrogen-poor ccSNe (70 ± 26 per cent). Similar results from Anderson et al. led to an interpretation that the progenitors of <span class="hlt">Type</span> <span class="hlt">Ib/c</span> ccSNe are more massive than those of <span class="hlt">Type</span> II ccSNe. Here, we quantify the luminosities of H ii region either coincident with or nearby to the ccSNe. Characteristic nebulae are long-lived (˜20 Myr) giant H ii regions rather than short-lived (˜4 Myr) isolated, compact H ii regions. Therefore, the absence of an H ii region from most <span class="hlt">Type</span> II ccSNe merely reflects the longer lifetime of stars with ⪉12 M⊙ than giant H ii regions. Conversely, the association of an H ii region with most <span class="hlt">Type</span> <span class="hlt">Ib/c</span> ccSNe is due to the shorter lifetime of stars with >12 M⊙ stars than the duty cycle of giant H ii regions. Therefore, we conclude that the observed association between certain ccSNe and H ii provides only weak constraints upon their progenitor masses. Nevertheless, we do favour lower mass progenitors for two <span class="hlt">Type</span> <span class="hlt">Ib/c</span> ccSNe that lack associated nebular emission, a host cluster or a nearby giant H ii region. Finally, we also reconsider the association between long gamma-ray bursts and the peak continuum light from their (mostly) dwarf hosts, and conclude that this is suggestive of very high mass progenitors, in common with previous studies.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017JaJAP..56iNA09C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017JaJAP..56iNA09C"><span>Image <span class="hlt">design</span> and replication for image-plane disk-<span class="hlt">type</span> multiplex holograms</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Chen, Chih-Hung; Cheng, Yih-Shyang</p> <p>2017-09-01</p> <p>The fabrication methods and parameter <span class="hlt">design</span> for both real-image generation and virtual-image display in image-plane disk-<span class="hlt">type</span> multiplex holography are introduced in this paper. A theoretical model of a disk-<span class="hlt">type</span> hologram is also presented and is then used in our two-step holographic processes, including the production of a non-image-plane master hologram and optical replication using a single-beam copying system for the production of duplicated holograms. Experimental results are also presented to verify the possibility of mass production using the one-shot holographic display technology described in this study.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29380430','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29380430"><span>Material <span class="hlt">Design</span> of p-<span class="hlt">Type</span> Transparent Amorphous Semiconductor, Cu-Sn-I.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Jun, Taehwan; Kim, Junghwan; Sasase, Masato; Hosono, Hideo</p> <p>2018-03-01</p> <p>Transparent amorphous semiconductors (TAS) that can be fabricated at low temperature are key materials in the practical application of transparent flexible electronics. Although various n-<span class="hlt">type</span> TAS materials with excellent performance, such as amorphous In-Ga-Zn-O (a-IGZO), are already known, no complementary p-<span class="hlt">type</span> TAS has been realized to date. Here, a material <span class="hlt">design</span> concept for p-<span class="hlt">type</span> TAS materials is proposed utilizing the pseudo s-orbital nature of spatially spreading iodine 5p orbitals and amorphous Sn-containing CuI (a-CuSnI) thin film is reported as an example. The resulting a-CuSnI thin films fabricated by spin coating at low temperature (140 °C) have a smooth surface. The Hall mobility increases with the hole concentration and the largest mobility of ≈9 cm 2 V -1 s -1 is obtained, which is comparable with that of conventional n-<span class="hlt">type</span> TAS. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22648698-mir-decreases-high-density-lipoprotein-induced-radiation-sensitivity-inbreast-cancer','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22648698-mir-decreases-high-density-lipoprotein-induced-radiation-sensitivity-inbreast-cancer"><span>MiR-33a Decreases High-Density Lipoprotein-Induced Radiation Sensitivity in Breast Cancer</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Wolfe, Adam R.; Bambhroliya, Arvind; Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas MD Anderson Cancer Center, Houston, Texas</p> <p></p> <p>Purpose: We previously showed that high-density lipoprotein (HDL) radiosensitizes inflammatory breast cancer (<span class="hlt">IBC</span>) cells in vitro and is associated with better local control after radiation therapy in <span class="hlt">IBC</span> patients. The microRNA miR-33 family negatively regulates the adenosine triphosphate binding cassette transporter subfamily A member 1. We hypothesized that variations in miR-33a expression in <span class="hlt">IBC</span> cancer cells versus non-<span class="hlt">IBC</span> cells would correlate with radiation sensitivity following exposure to HDL in vitro. Methods and Materials: MiR-33a expression was analyzed by reverse transcriptase–polymerase chain reaction in 4 cell lines representing common clinical breast cancer subtypes. Overexpression and knockdown of miR-33a was demonstrated via transfection of anmore » miR-33a mimic or an anti-miR-33a construct in high- and low-expressing miR-33a cell lines. Clonogenic survival in vitro in these cells was quantified at baseline and following HDL treatment. MiR-33a expression on distant relapse-free survival (DRFS) of 210 cases downloaded from the Oxford breast cancer dataset was determined. Results: Expression levels of miR-33a were lower in <span class="hlt">IBC</span> cell lines and <span class="hlt">IBC</span> tumor samples than in non-<span class="hlt">IBC</span> cell lines and normal breast tissue. Cholesterol concentrations in the cell membranes were higher in <span class="hlt">IBC</span> cells than in non-<span class="hlt">IBC</span> cells. Clonogenic survival following 24 hours of HDL treatment was decreased in response to irradiation in the low-miR-33a–expressing cell lines SUM149 and KPL4, but survival following HDL treatment decreased in the high-miR-33a–expressing cell lines MDA-MB-231 and SUM159. In the high-miR-33a–expressing cell lines, anti-miR-33a transfection decreased radiation resistance in clonogenic assays. Conversely, in the low-miR-33a–expressing cell lines, the miR-33a mimic reversed the HDL-induced radiation sensitization. Breast cancer patients in the top quartile based on miR-33a expression had markedly lower rates of DRFS than the bottom</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4650771','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4650771"><span>Intracellular Bacteria in the Pathogenesis of Escherichia coli Urinary Tract Infection in Children</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Robino, Luciana; Scavone, Paola; Araujo, Lucia; Algorta, Gabriela; Zunino, Pablo; Pírez, María Catalina; Vignoli, Rafael</p> <p>2014-01-01</p> <p>Background. Uropathogenic Escherichia coli (UPEC) is the most common agent of urinary tract infection (UTI). The classic model of pathogenesis proposes the ascent of UPEC by the urethra and external adherence to the urothelium. Recently, the ability of UPEC to invade urothelial cells and to form intracellular bacterial communities (<span class="hlt">IBCs</span>) has been described. Methods. The objective of the present study was to determine the presence of intracellular bacteria (IB) in children with UTI caused by E. coli and to characterize its virulence attributes and its relation with clinical outcomes. One hundred thirty-three children with E. coli UTI who attended a reference children's hospital between June and November 2012 were included. Urine samples were analyzed by optical and confocal microscopy looking for exfoliated urothelial cells with IB. Phylogenetic group and 24 virulence factors of UPEC were determined using multiplex polymerase chain reaction. Medical records were analyzed. Results. The presence of IB was detected in 49 of 133 (36.8%) samples by confocal microscopy, in 30 cases as <span class="hlt">IBC</span>, and in 19 as isolated intracellular bacteria (IIB). Only 50% of these cases could be detected by light microscopy. Seventy-four medical records were analyzed, 34 with <span class="hlt">IBC</span>/IIB, 40 without IB. Any virulence gene was associated with <span class="hlt">IBC</span>/IIB. The presence of <span class="hlt">IBC</span>/IIB was associated with recurrent UTI (odds ratio [OR], 3.3; 95% confidence interval [CI], 1.3–9; P = .017), especially in children without urinary tract functional or morphological abnormalities (OR, 8.0; 95% CI, 2.3–27.4; P = .000). <span class="hlt">IBCs</span> were associated with lower urinary tract syndrome (OR, 3.6; 95% CI, 1.1–11.8; P = .05) and absence of fever (P = .009). Conclusions. <span class="hlt">IBCs</span>/IIB could explain a high proportion of children with recurrent UTI. PMID:25091303</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4499776','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4499776"><span>Noninvasive Quantitative Imaging of Collagen Microstructure in Three-Dimensional Hydrogels Using High-Frequency Ultrasound</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Mercado, Karla P.; Helguera, María; Hocking, Denise C.</p> <p>2015-01-01</p> <p>Collagen I is widely used as a natural component of biomaterials for both tissue engineering and regenerative medicine applications. The physical and biological properties of fibrillar collagens are strongly tied to variations in collagen fiber microstructure. The goal of this study was to develop the use of high-frequency quantitative ultrasound to assess collagen microstructure within three-dimensional (3D) hydrogels noninvasively and nondestructively. The integrated backscatter coefficient (<span class="hlt">IBC</span>) was employed as a quantitative ultrasound parameter to detect, image, and quantify spatial variations in collagen fiber density and diameter. Collagen fiber microstructure was varied by fabricating hydrogels with different collagen concentrations or polymerization temperatures. <span class="hlt">IBC</span> values were computed from measurements of the backscattered radio-frequency ultrasound signals collected using a single-element transducer (38-MHz center frequency, 13–47 MHz bandwidth). The <span class="hlt">IBC</span> increased linearly with increasing collagen concentration and decreasing polymerization temperature. Parametric 3D images of the <span class="hlt">IBC</span> were generated to visualize and quantify regional variations in collagen microstructure throughout the volume of hydrogels fabricated in standard tissue culture plates. <span class="hlt">IBC</span> parametric images of corresponding cell-embedded collagen gels showed cell accumulation within regions having elevated collagen <span class="hlt">IBC</span> values. The capability of this ultrasound technique to noninvasively detect and quantify spatial differences in collagen microstructure offers a valuable tool to monitor the structural properties of collagen scaffolds during fabrication, to detect functional differences in collagen microstructure, and to guide fundamental research on the interactions of cells and collagen matrices. PMID:25517512</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25517512','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25517512"><span>Noninvasive Quantitative Imaging of Collagen Microstructure in Three-Dimensional Hydrogels Using High-Frequency Ultrasound.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Mercado, Karla P; Helguera, María; Hocking, Denise C; Dalecki, Diane</p> <p>2015-07-01</p> <p>Collagen I is widely used as a natural component of biomaterials for both tissue engineering and regenerative medicine applications. The physical and biological properties of fibrillar collagens are strongly tied to variations in collagen fiber microstructure. The goal of this study was to develop the use of high-frequency quantitative ultrasound to assess collagen microstructure within three-dimensional (3D) hydrogels noninvasively and nondestructively. The integrated backscatter coefficient (<span class="hlt">IBC</span>) was employed as a quantitative ultrasound parameter to detect, image, and quantify spatial variations in collagen fiber density and diameter. Collagen fiber microstructure was varied by fabricating hydrogels with different collagen concentrations or polymerization temperatures. <span class="hlt">IBC</span> values were computed from measurements of the backscattered radio-frequency ultrasound signals collected using a single-element transducer (38-MHz center frequency, 13-47 MHz bandwidth). The <span class="hlt">IBC</span> increased linearly with increasing collagen concentration and decreasing polymerization temperature. Parametric 3D images of the <span class="hlt">IBC</span> were generated to visualize and quantify regional variations in collagen microstructure throughout the volume of hydrogels fabricated in standard tissue culture plates. <span class="hlt">IBC</span> parametric images of corresponding cell-embedded collagen gels showed cell accumulation within regions having elevated collagen <span class="hlt">IBC</span> values. The capability of this ultrasound technique to noninvasively detect and quantify spatial differences in collagen microstructure offers a valuable tool to monitor the structural properties of collagen scaffolds during fabrication, to detect functional differences in collagen microstructure, and to guide fundamental research on the interactions of cells and collagen matrices.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20100024151','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20100024151"><span>Development and Operation of an Automatic Rotor Trim Control System for use During the UH-60 Individual Blade Control Wind Tunnel Test</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Theodore, Colin R.</p> <p>2010-01-01</p> <p>A full-scale wind tunnel test to evaluate the effects of Individual Blade Control (<span class="hlt">IBC</span>) on the performance, vibration, noise and loads of a UH-60A rotor was recently completed in the National Full-Scale Aerodynamics Complex (NFAC) 40- by 80-Foot Wind Tunnel [1]. A key component of this wind tunnel test was an automatic rotor trim control system that allowed the rotor trim state to be set more precisely, quickly and repeatably than was possible with the rotor operator setting the trim condition manually. The trim control system was also able to maintain the desired trim condition through changes in <span class="hlt">IBC</span> actuation both in open- and closed-loop <span class="hlt">IBC</span> modes, and through long-period transients in wind tunnel flow. This ability of the trim control system to automatically set and maintain a steady rotor trim enabled the effects of different <span class="hlt">IBC</span> inputs to be compared at common trim conditions and to perform these tests quickly without requiring the rotor operator to re-trim the rotor. The trim control system described in this paper was developed specifically for use during the <span class="hlt">IBC</span> wind tunnel test</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29411137','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29411137"><span>Isobavachalcone inhibits post-entry stages of the porcine reproductive and respiratory syndrome virus life cycle.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wang, Hai-Ming; Liu, Tian-Xin; Wang, Tong-Yun; Wang, Gang; Liu, Yong-Gang; Liu, Si-Guo; Tang, Yan-Dong; Cai, Xue-Hui</p> <p>2018-05-01</p> <p>Porcine reproductive and respiratory syndrome virus (PRRSV) is a pathogen of great economic significance that impacts the swine industry globally. Since the first report of a porcine reproductive and respiratory syndrome (PRRS) outbreak, tremendous efforts to control this disease, including various national policies and plans incorporating the use of multiple modified live-virus vaccines, have been made. However, PRRSV is still a significant threat to the swine industry, and new variants continually emerge as a result of PRRSV evolution. Several studies have shown that pandemic PRRSV strains have enormous genetic diversity and that commercial vaccines can only provide partial protection against these strains. Therefore, effective anti-PRRSV drugs may be more suitable and reliable for PRRSV control. In this study, we observed that isobavachalcone (<span class="hlt">IBC</span>), which was first isolated from Psoralea corylifolia, had potent anti-PRRSV activity in vitro. Although many biological activities of <span class="hlt">IBC</span> have been reported, this is the first report describing the antiviral activity of <span class="hlt">IBC</span>. Furthermore, after a systematic investigation, we demonstrated that <span class="hlt">IBC</span> inhibits PRRSV replication at the post-entry stage of PRRSV infection. Thus, <span class="hlt">IBC</span> may be a candidate for further evaluation as a therapeutic agent against PRRSV infection of swine in vivo.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li class="active"><span>14</span></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_14 --> <div id="page_15" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li class="active"><span>15</span></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="281"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25738535','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25738535"><span>Rational drug <span class="hlt">design</span> and synthesis of molecules targeting the angiotensin II <span class="hlt">type</span> 1 and <span class="hlt">type</span> 2 receptors.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kellici, Tahsin F; Tzakos, Andreas G; Mavromoustakos, Thomas</p> <p>2015-03-02</p> <p>The angiotensin II (Ang II) <span class="hlt">type</span> 1 and <span class="hlt">type</span> 2 receptors (AT1R and AT2R) orchestrate an array of biological processes that regulate human health. Aberrant function of these receptors triggers pathophysiological responses that can ultimately lead to death. Therefore, it is important to <span class="hlt">design</span> and synthesize compounds that affect beneficially these two receptors. Cardiovascular disease, which is attributed to the overactivation of the vasoactive peptide hormone Αng II, can now be treated with commercial AT1R antagonists. Herein, recent achievements in rational drug <span class="hlt">design</span> and synthesis of molecules acting on the two AT receptors are reviewed. Quantitative structure activity relationships (QSAR) and molecular modeling on the two receptors aim to assist the search for new active compounds. As AT1R and AT2R are GPCRs and drug action is localized in the transmembrane region the role of membrane bilayers is exploited. The future perspectives in this field are outlined. Tremendous progress in the field is expected if the two receptors are crystallized, as this will assist the structure based screening of the chemical space and lead to new potent therapeutic agents in cardiovascular and other diseases.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22612604-design-kj-mather-type-plasma-focus-device','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22612604-design-kj-mather-type-plasma-focus-device"><span><span class="hlt">Design</span> of a 500-kJ Mather-<span class="hlt">type</span> plasma focus device</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Heidarnia, A., E-mail: a-heidarnia@yahoo.com; Sadighzadeh, A.; Zaeem, A. A.</p> <p></p> <p>In this article, <span class="hlt">design</span> of a 500-kJ Mather-<span class="hlt">type</span> plasma focus device to achieve 10{sup 11} neutrons/shot is reported. One of its important characteristics is the triple-part anode <span class="hlt">design</span>. The anode is surrounded by an alumina insulator. The second part of the anode is changeable in order to locate cylindrical, conical, or other shapes of pieces mounted on it. This geometry leads to the easier investigation of the neutron and X-ray emissions of the device. The third part of the anode is for changing the materials exposed to different kinds of radiations. The <span class="hlt">design</span> parameters are considered by semiempirical and empiricalmore » formulas and are sketched by Solidworks software. Also, the peak current and neutron yield are estimated.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19890017488','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19890017488"><span><span class="hlt">Design</span> of an active helicopter control experiment at the Princeton Rotorcraft Dynamics Laboratory</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Marraffa, Andrew M.; Mckillip, R. M., Jr.</p> <p>1989-01-01</p> <p>In an effort to develop an active control technique for reducing helicopter vibrations stemming from the main rotor system, a helicopter model was <span class="hlt">designed</span> and tested at the Princeton Rotorcraft Dynamics Laboratory (PRDL). A description of this facility, including its latest data acquisition upgrade, are given. The <span class="hlt">design</span> procedures for the test model and its Froude scaled rotor system are also discussed. The approach for performing active control is based on the idea that rotor states can be identified by instrumenting the rotor blades. Using this knowledge, Individual Blade Control (<span class="hlt">IBC</span>) or Higher Harmonic Control (HHC) pitch input commands may be used to impact on rotor dynamics in such a way as to reduce rotor vibrations. Discussed here is an instrumentation configuration utilizing miniature accelerometers to measure and estimate first and second out-of-plane bending mode positions and velocities. To verify this technique, the model was tested, and resulting data were used to estimate rotor states as well as flap and bending coefficients, procedures for which are discussed. Overall results show that a cost- and time-effective method for building a useful test model for future active control experiments was developed. With some fine-tuning or slight adjustments in sensor configuration, prospects for obtaining good state estimates look promising.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA532073','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA532073"><span>Investigation of Rotor Performance and Loads of a UH-60A Individual Blade Control System</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2010-05-01</p> <p>the pitch link for each rotor blade with an actuator so that the blade root pitch angles could be changed independently. This <span class="hlt">design</span> was previously...with the ultimate goal of providing the technology for timely and cost-effective <span class="hlt">design</span> and development of new rotors. Analytical studies on <span class="hlt">IBC</span> [8...rotor with coincident flap and lag articulation provided at the blade root by elastomeric bearings. This bearing, through the rotor spindle , also</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/1515282','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/1515282"><span>PLS-based quantitative structure-activity relationship for substituted benzamides of clebopride <span class="hlt">type</span>. Application of experimental <span class="hlt">design</span> in drug <span class="hlt">design</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Norinder, U; Högberg, T</p> <p>1992-04-01</p> <p>The advantageous approach of using an experimentally <span class="hlt">designed</span> training set as the basis for establishing a quantitative structure-activity relationship with good predictive capability is described. The training set was selected from a fractional factorial <span class="hlt">design</span> scheme based on a principal component description of physico-chemical parameters of aromatic substituents. The derived model successfully predicts the activities of additional substituted benzamides of 6-methoxy-N-(4-piperidyl)salicylamide <span class="hlt">type</span>. The major influence on activity of the 3-substituent is demonstrated.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016NatSR...629626W','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016NatSR...629626W"><span>Reflection <span class="hlt">type</span> metasurface <span class="hlt">designed</span> for high efficiency vectorial field generation</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Wang, Shiyi; Zhan, Qiwen</p> <p>2016-07-01</p> <p>We propose a reflection <span class="hlt">type</span> metal-insulator-metal (MIM) metasurface composed of hybrid nano-antennas for comprehensive spatial engineering of the properties of optical fields. The capability of such structure is illustrated in the <span class="hlt">design</span> of a device that can be used to produce a radially polarized vectorial beam for optical needle field generation. This device consists of uniformly segmented sectors of high efficiency MIM metasurface. With each of the segment sector functioning as a local quarter-wave-plate (QWP), the device is <span class="hlt">designed</span> to convert circularly polarized incidence into local linear polarization to create an overall radial polarization with corresponding binary phases and extremely high dynamic range amplitude modulation. The capability of such devices enables the generation of nearly arbitrarily complex optical fields that may find broad applications that transcend disciplinary boundaries.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28952800','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28952800"><span><span class="hlt">Designing</span> Anti-Binge Drinking Prevention Messages: Message Framing vs. Evidence <span class="hlt">Type</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kang, Hannah; Lee, Moon J</p> <p>2017-09-27</p> <p>We investigated whether presenting anti-binge drinking health campaign messages in different message framing and evidence <span class="hlt">types</span> influences college students' intention to avoid binge drinking, based on prospect theory (PT) and exemplification theory. A 2 (message framing: loss-framed message/gain-framed message) X 2 (evidence <span class="hlt">type</span>: statistical/narrative) between-subjects factorial <span class="hlt">design</span> with a control group was conducted with 156 college students. College students who were exposed to the loss-framed message condition exhibited a higher level of intention to avoid binge drinking in the near future than those who did not see any messages (the control group). This finding was mainly among non-binge drinkers. Regardless of evidence <span class="hlt">type</span>, those who were exposed to the messages exhibited a higher level of intention to avoid binge drinking than those in the control group. This is also mainly among non-binge drinkers. We also found the main effects of message framing and evidence <span class="hlt">type</span> on attitude toward the message and the main effect of message framing on attitude toward drinking.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=ibs&pg=7&id=EJ943504','ERIC'); return false;" href="https://eric.ed.gov/?q=ibs&pg=7&id=EJ943504"><span>Backward Blocking and Interference between Cues Are Empirically Equivalent in Non-Causally Framed Learning Tasks</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Luque, David; Moris, Joaquin; Orgaz, Cristina; Cobos, Pedro L.; Matute, Helena</p> <p>2011-01-01</p> <p>Backward blocking (BB) and interference between cues (<span class="hlt">IbC</span>) are cue competition effects produced by very similar manipulations. In a standard BB <span class="hlt">design</span>, both effects might occur simultaneously, which implies a potential problem for studying BB. In the present study with humans, the magnitude of both effects was compared using a non-causal scenario…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5342396','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5342396"><span>NHERF1, a novel GPER associated protein, increases stability and activation of GPER in ER-positive breast cancer</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Xiong, Ying; Wang, Yan; Zheng, Junfang; Zhao, Yuan; Tao, Tao; Wang, Qiqi; Liu, Hua; Wang, Songlin; Jiang, Wen G.; He, Junqi</p> <p>2016-01-01</p> <p>G protein-coupled estrogen receptor (GPER) plays an important role in mediating the effects of estradiol. High levels of GPER have been implicated to associate with the malignant progress of invasive breast cancer (<span class="hlt">IBC</span>). However, the mechanisms by which GPER protein levels were regulated remain unclear. In this study, PDZ protein Na+/H+ exchanger regulatory factor (NHERF1) was found to interact with GPER in breast cancer cells. This interaction was mediated by the PDZ2 domain of NHERF1 and the carboxyl terminal PDZ binding motif of GPER. NHERF1 was demonstrated to facilitate GPER expression at post-transcriptional level and improve GPER protein stability by inhibiting the receptor degradation via ubiquitin-proteasome pathway in a GPER/NHERF1 interaction-dependent manner. In addition, GPER protein levels are positively associated with NHERF1 protein levels in a panel of estrogen receptor (ER)-positive breast cancer cells. Furthermore, analysis of clinical <span class="hlt">IBC</span> data from The Cancer Genome Atlas (TCGA) showed no significant difference in GPER mRNA levels between ER-positive <span class="hlt">IBC</span> and normal breast tissues. However, gene set enrichment analysis (GSEA) showed that GPER signaling is ultra-activated in ER-positive <span class="hlt">IBC</span> when compared with normal and its activation is positively associated with NHERF1 mRNA levels. Taken together, our findings identify NHERF1 as a new binding partner for GPER and its overexpression promotes protein stability and activation of GPER in ER-positive <span class="hlt">IBC</span>. Our data indicate that regulation of GPER stability by NHERF1 may contribute to GPER-mediated carcinogenesis in ER-positive <span class="hlt">IBC</span>. PMID:27448983</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27448983','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27448983"><span>NHERF1, a novel GPER associated protein, increases stability and activation of GPER in ER-positive breast cancer.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Meng, Ran; Qin, Qiong; Xiong, Ying; Wang, Yan; Zheng, Junfang; Zhao, Yuan; Tao, Tao; Wang, Qiqi; Liu, Hua; Wang, Songlin; Jiang, Wen G; He, Junqi</p> <p>2016-08-23</p> <p>G protein-coupled estrogen receptor (GPER) plays an important role in mediating the effects of estradiol. High levels of GPER have been implicated to associate with the malignant progress of invasive breast cancer (<span class="hlt">IBC</span>). However, the mechanisms by which GPER protein levels were regulated remain unclear. In this study, PDZ protein Na+/H+ exchanger regulatory factor (NHERF1) was found to interact with GPER in breast cancer cells. This interaction was mediated by the PDZ2 domain of NHERF1 and the carboxyl terminal PDZ binding motif of GPER. NHERF1 was demonstrated to facilitate GPER expression at post-transcriptional level and improve GPER protein stability by inhibiting the receptor degradation via ubiquitin-proteasome pathway in a GPER/NHERF1 interaction-dependent manner. In addition, GPER protein levels are positively associated with NHERF1 protein levels in a panel of estrogen receptor (ER)-positive breast cancer cells. Furthermore, analysis of clinical <span class="hlt">IBC</span> data from The Cancer Genome Atlas (TCGA) showed no significant difference in GPER mRNA levels between ER-positive <span class="hlt">IBC</span> and normal breast tissues. However, gene set enrichment analysis (GSEA) showed that GPER signaling is ultra-activated in ER-positive <span class="hlt">IBC</span> when compared with normal and its activation is positively associated with NHERF1 mRNA levels. Taken together, our findings identify NHERF1 as a new binding partner for GPER and its overexpression promotes protein stability and activation of GPER in ER-positive <span class="hlt">IBC</span>. Our data indicate that regulation of GPER stability by NHERF1 may contribute to GPER-mediated carcinogenesis in ER-positive <span class="hlt">IBC</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title49-vol6/pdf/CFR-2013-title49-vol6-sec451-13.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title49-vol6/pdf/CFR-2013-title49-vol6-sec451-13.pdf"><span>49 CFR 451.13 - Action by approval authority-approval by <span class="hlt">design</span> <span class="hlt">type</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-10-01</p> <p>...) COAST GUARD, DEPARTMENT OF HOMELAND SECURITY SAFETY APPROVAL OF CARGO CONTAINERS TESTING AND APPROVAL OF CONTAINERS Approval of New Containers § 451.13 Action by approval authority-approval by <span class="hlt">design</span> <span class="hlt">type</span>. (a) The... of safety approval plates to the containers. Absence of individual inspections will not relieve the...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol6/pdf/CFR-2010-title49-vol6-sec451-13.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol6/pdf/CFR-2010-title49-vol6-sec451-13.pdf"><span>49 CFR 451.13 - Action by approval authority-approval by <span class="hlt">design</span> <span class="hlt">type</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>...) COAST GUARD, DEPARTMENT OF HOMELAND SECURITY SAFETY APPROVAL OF CARGO CONTAINERS TESTING AND APPROVAL OF CONTAINERS Approval of New Containers § 451.13 Action by approval authority-approval by <span class="hlt">design</span> <span class="hlt">type</span>. (a) The... of safety approval plates to the containers. Absence of individual inspections will not relieve the...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title49-vol6/pdf/CFR-2012-title49-vol6-sec451-13.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title49-vol6/pdf/CFR-2012-title49-vol6-sec451-13.pdf"><span>49 CFR 451.13 - Action by approval authority-approval by <span class="hlt">design</span> <span class="hlt">type</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-10-01</p> <p>...) COAST GUARD, DEPARTMENT OF HOMELAND SECURITY SAFETY APPROVAL OF CARGO CONTAINERS TESTING AND APPROVAL OF CONTAINERS Approval of New Containers § 451.13 Action by approval authority-approval by <span class="hlt">design</span> <span class="hlt">type</span>. (a) The... of safety approval plates to the containers. Absence of individual inspections will not relieve the...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title49-vol6/pdf/CFR-2011-title49-vol6-sec451-13.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title49-vol6/pdf/CFR-2011-title49-vol6-sec451-13.pdf"><span>49 CFR 451.13 - Action by approval authority-approval by <span class="hlt">design</span> <span class="hlt">type</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-10-01</p> <p>...) COAST GUARD, DEPARTMENT OF HOMELAND SECURITY SAFETY APPROVAL OF CARGO CONTAINERS TESTING AND APPROVAL OF CONTAINERS Approval of New Containers § 451.13 Action by approval authority-approval by <span class="hlt">design</span> <span class="hlt">type</span>. (a) The... of safety approval plates to the containers. Absence of individual inspections will not relieve the...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title49-vol6/pdf/CFR-2014-title49-vol6-sec451-13.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title49-vol6/pdf/CFR-2014-title49-vol6-sec451-13.pdf"><span>49 CFR 451.13 - Action by approval authority-approval by <span class="hlt">design</span> <span class="hlt">type</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-10-01</p> <p>...) COAST GUARD, DEPARTMENT OF HOMELAND SECURITY SAFETY APPROVAL OF CARGO CONTAINERS TESTING AND APPROVAL OF CONTAINERS Approval of New Containers § 451.13 Action by approval authority-approval by <span class="hlt">design</span> <span class="hlt">type</span>. (a) The... of safety approval plates to the containers. Absence of individual inspections will not relieve the...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title19-vol1/pdf/CFR-2012-title19-vol1-sec115-65.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title19-vol1/pdf/CFR-2012-title19-vol1-sec115-65.pdf"><span>19 CFR 115.65 - Technical requirements for road vehicles by <span class="hlt">design</span> <span class="hlt">type</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-04-01</p> <p>... 19 Customs Duties 1 2012-04-01 2012-04-01 false Technical requirements for road vehicles by <span class="hlt">design</span> <span class="hlt">type</span>. 115.65 Section 115.65 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title19-vol1/pdf/CFR-2011-title19-vol1-sec115-65.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title19-vol1/pdf/CFR-2011-title19-vol1-sec115-65.pdf"><span>19 CFR 115.65 - Technical requirements for road vehicles by <span class="hlt">design</span> <span class="hlt">type</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-04-01</p> <p>... 19 Customs Duties 1 2011-04-01 2011-04-01 false Technical requirements for road vehicles by <span class="hlt">design</span> <span class="hlt">type</span>. 115.65 Section 115.65 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title19-vol1/pdf/CFR-2013-title19-vol1-sec115-65.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title19-vol1/pdf/CFR-2013-title19-vol1-sec115-65.pdf"><span>19 CFR 115.65 - Technical requirements for road vehicles by <span class="hlt">design</span> <span class="hlt">type</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-04-01</p> <p>... 19 Customs Duties 1 2013-04-01 2013-04-01 false Technical requirements for road vehicles by <span class="hlt">design</span> <span class="hlt">type</span>. 115.65 Section 115.65 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title19-vol1/pdf/CFR-2014-title19-vol1-sec115-65.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title19-vol1/pdf/CFR-2014-title19-vol1-sec115-65.pdf"><span>19 CFR 115.65 - Technical requirements for road vehicles by <span class="hlt">design</span> <span class="hlt">type</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-04-01</p> <p>... 19 Customs Duties 1 2014-04-01 2014-04-01 false Technical requirements for road vehicles by <span class="hlt">design</span> <span class="hlt">type</span>. 115.65 Section 115.65 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title19-vol1/pdf/CFR-2010-title19-vol1-sec115-65.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title19-vol1/pdf/CFR-2010-title19-vol1-sec115-65.pdf"><span>19 CFR 115.65 - Technical requirements for road vehicles by <span class="hlt">design</span> <span class="hlt">type</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-04-01</p> <p>... 19 Customs Duties 1 2010-04-01 2010-04-01 false Technical requirements for road vehicles by <span class="hlt">design</span> <span class="hlt">type</span>. 115.65 Section 115.65 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO...</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li class="active"><span>15</span></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_15 --> <div id="page_16" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li class="active"><span>16</span></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="301"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3953399','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3953399"><span>A Preliminary Investigation of User Perception and Behavioral Intention for Different Review <span class="hlt">Types</span>: Customers and <span class="hlt">Designers</span> Perspective</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Qazi, Atika; Waheed, Mahwish; Abraham, Ajith</p> <p>2014-01-01</p> <p>Existing opinion mining studies have focused on and explored only two <span class="hlt">types</span> of reviews, that is, regular and comparative. There is a visible gap in determining the useful review <span class="hlt">types</span> from customers and <span class="hlt">designers</span> perspective. Based on Technology Acceptance Model (TAM) and statistical measures we examine users' perception about different review <span class="hlt">types</span> and its effects in terms of behavioral intention towards using online review system. By using sample of users (N = 400) and <span class="hlt">designers</span> (N = 106), current research work studies three review <span class="hlt">types</span>, A (regular), B (comparative), and C (suggestive), which are related to perceived usefulness, perceived ease of use, and behavioral intention. The study reveals that positive perception of the use of suggestive reviews improves users' decision making in business intelligence. The results also depict that <span class="hlt">type</span> C (suggestive reviews) could be considered a new useful review <span class="hlt">type</span> in addition to other <span class="hlt">types</span>, A and B. PMID:24711739</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017MS%26E..227a2053G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017MS%26E..227a2053G"><span>Analysis of <span class="hlt">design</span> characteristics of a V-<span class="hlt">type</span> support using an advanced engineering environment</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Gwiazda, A.; Banaś, W.; Sękala, A.; Cwikla, G.; Topolska, S.; Foit, K.; Monica, Z.</p> <p>2017-08-01</p> <p>Modern mining support, for the entire period of their use, is the important part of the mining complex, which includes all the devices in the excavation during his normal use. Therefore, during the <span class="hlt">design</span> of the support, it is an important task to choose the shape and to select the dimensions of a support as well as its strength characteristics. According to the rules, the <span class="hlt">design</span> process of a support must take into account, inter alia, the <span class="hlt">type</span> and the dimensions of the expected means of transport, the number and size of pipelines, and the <span class="hlt">type</span> of additional equipment used excavation area. The support <span class="hlt">design</span> must ensure the functionality of the excavation process and job security, while maintaining the economic viability of the entire project. Among others it should ensure the selection of a support for specific natural conditions. It is also important to take into consideration the economic characteristics of the project. The article presents an algorithm of integrative approach and its formalized description in the form of integration the areas of different construction characteristics optimization of a V-<span class="hlt">type</span> mining support. The paper includes the example of its application for developing the construction of this support. In the paper is also described the results of the characteristics analysis and changings that were introduced afterwards. The support models are prepared in the computer environment of the CAD class (Siemens NX PLM). Also the analyses were conducted in this <span class="hlt">design</span>, graphical environment.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20090006883&hterms=investment+property&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D90%26Ntt%3Dinvestment%2Bproperty','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20090006883&hterms=investment+property&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D90%26Ntt%3Dinvestment%2Bproperty"><span>Ultraviolet Spectroscopy of Supernovae: The First Two Years of Swift Observations</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Immler, Stefan</p> <p>2008-01-01</p> <p>We present the entire sample of ultraviolet (1JV) spectra of supernovae (SNe) obtained with the Ultraviolet/Optical Telescope (UVOT) on board the Swift satellite during the first 2 years of observations (2005/2006). A total of 31 UV-grism and 22 V-grism spectra of 9 supernovae (SNe) have been collected. of which 6 are thermonuclear (<span class="hlt">type</span> Ia) and 3 core collapse (<span class="hlt">type</span> <span class="hlt">Ibc</span>/II) SNe. All the spectra have been obtained during the photospheric phase. After a comparison of the spectra of our sample with those in the literature (SNe 1992A. 1990N and 1999em). we confirm some degree of diversity in the UV emission of <span class="hlt">Type</span> Ia SNe and a greater homogeneity in the <span class="hlt">Type</span> I1 Plateau SN sample. Signatures of interaction between the ejecta and the circumstellar environment have been found in the UV spectrum of SN 2006jc, the only SN <span class="hlt">Type</span> <span class="hlt">Ib/c</span> for which UVOT grism data are available. Currently, Swift LJVOT is the best suited instrument for early SN studies in the UV due to its fast response and flexible scheduling capabilities. However. in order to increase the quality of the data and significantly improve our understanding of the lJV properties of SNe and to fully maximize the scientific potential of UVOT grism observations. a larger investment in obsening time and longer exposures are needed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=private+AND+sector+AND+us&pg=5&id=ED554124','ERIC'); return false;" href="https://eric.ed.gov/?q=private+AND+sector+AND+us&pg=5&id=ED554124"><span>An Examination of Interconnectedness between U.S. International Branch Campuses and Their Host Countries</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Crombie-Borgos, Jill</p> <p>2013-01-01</p> <p>This qualitative study examines U. S. international branch campus (<span class="hlt">IBC</span>) administrative leadership structures and the interconnections they have to their respective host countries. While several factors concerning the sustainability of <span class="hlt">IBCs</span> have been cited, this study introduces "leadership networks" to the discourse on IBC…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title49-vol3/pdf/CFR-2014-title49-vol3-sec178-700.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title49-vol3/pdf/CFR-2014-title49-vol3-sec178-700.pdf"><span>49 CFR 178.700 - Purpose, scope and definitions.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-10-01</p> <p>... Performance-Oriented Standards § 178.700 Purpose, scope and definitions. (a) This subpart prescribes requirements applying to <span class="hlt">IBCs</span> intended for the transportation of hazardous materials. Standards for these... subchapter and in paragraph (c) of this section. (c) The following definitions pertain to the <span class="hlt">IBC</span> standards...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title49-vol3/pdf/CFR-2012-title49-vol3-sec178-700.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title49-vol3/pdf/CFR-2012-title49-vol3-sec178-700.pdf"><span>49 CFR 178.700 - Purpose, scope and definitions.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-10-01</p> <p>... Performance-Oriented Standards § 178.700 Purpose, scope and definitions. (a) This subpart prescribes requirements applying to <span class="hlt">IBCs</span> intended for the transportation of hazardous materials. Standards for these... subchapter and in paragraph (c) of this section. (c) The following definitions pertain to the <span class="hlt">IBC</span> standards...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017E%26ES...69a2183D','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017E%26ES...69a2183D"><span>Structure <span class="hlt">design</span> and motion simulation of the pin-cycloid gear planetary reducer with ring-plate-<span class="hlt">type</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Duan, Hongjie; Li, Lijun; Tao, Junyi</p> <p>2017-06-01</p> <p>The pin-cycloid gear planetary reducer with ring-plate-<span class="hlt">type</span> is a new <span class="hlt">type</span> of reducers. It has high transmission ratio range and high efficiency. In this paper the working principle of pin-cycloid gear planetary reducer is discussed, and the structure of the reducer is <span class="hlt">designed</span>. Especially for the complexity and the difficulty in modelling of the cycloid gear tooth profile, the parametric <span class="hlt">design</span> module of cycloid gear is developed to solve the cycloid gear modelling problem through the second development of Solid Works. At last, the speed schemes of the input shaft and output shaft of the reducer are obtained by the motion simulation. Through the analysis of the simulation curves, the rationality of the structure <span class="hlt">design</span> is proved, which provides a theoretical basis for the <span class="hlt">design</span> and manufacture of the reducer.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22105856-development-neutronics-calculation-method-designing-commercial-type-japanese-sodium-cooled-fast-reactor','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22105856-development-neutronics-calculation-method-designing-commercial-type-japanese-sodium-cooled-fast-reactor"><span>Development of a neutronics calculation method for <span class="hlt">designing</span> commercial <span class="hlt">type</span> Japanese sodium-cooled fast reactor</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Takeda, T.; Shimazu, Y.; Hibi, K.</p> <p>2012-07-01</p> <p>Under the R and D project to improve the modeling accuracy for the <span class="hlt">design</span> of fast breeder reactors the authors are developing a neutronics calculation method for <span class="hlt">designing</span> a large commercial <span class="hlt">type</span> sodium- cooled fast reactor. The calculation method is established by taking into account the special features of the reactor such as the use of annular fuel pellet, inner duct tube in large fuel assemblies, large core. The Verification and Validation, and Uncertainty Qualification (V and V and UQ) of the calculation method is being performed by using measured data from the prototype FBR Monju. The results of thismore » project will be used in the <span class="hlt">design</span> and analysis of the commercial <span class="hlt">type</span> demonstration FBR, known as the Japanese Sodium fast Reactor (JSFR). (authors)« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/publication/?seqNo115=330533','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/publication/?seqNo115=330533"><span>(001–003) Proposals relating to the valid publication of new combinations, names at new rank, and replacement names (Art. 41)</span></a></p> <p><a target="_blank" href="https://www.ars.usda.gov/research/publications/find-a-publication/">USDA-ARS?s Scientific Manuscript database</a></p> <p></p> <p></p> <p>The International Code of Nomenclature for algae, fungi and plants is revised every six years to incorporate decisions of the Nomenclature Section of successive International Botanical Congresses (<span class="hlt">IBC</span>) on proposals to amend the Code. The proposals in this paper will be considered at the <span class="hlt">IBC</span> in Shenz...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/publication/?seqNo115=331418','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/publication/?seqNo115=331418"><span>(385-388) Proposals to amend Art. 32.2, 23.5, and 24.2 to clarify the treatment of transcribed Greek terminations of epithets</span></a></p> <p><a target="_blank" href="https://www.ars.usda.gov/research/publications/find-a-publication/">USDA-ARS?s Scientific Manuscript database</a></p> <p></p> <p></p> <p>The International Code of Nomenclature for algae, fungi and plants is revised every six years to incorporate decisions of the Nomenclature Section of successive International Botanical Congresses (<span class="hlt">IBC</span>) on proposals to amend the Code. The proposals in this paper will be considered at the <span class="hlt">IBC</span> in Shenz...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/publication/?seqNo115=332431','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/publication/?seqNo115=332431"><span>(364) Proposal to provide a more direct definition of the term “gathering”</span></a></p> <p><a target="_blank" href="https://www.ars.usda.gov/research/publications/find-a-publication/">USDA-ARS?s Scientific Manuscript database</a></p> <p></p> <p></p> <p>The International Code of Nomenclature for algae, fungi and plants is revised every six years to incorporate decisions of the Nomenclature Section of successive International Botanical Congresses (<span class="hlt">IBC</span>) on proposals to amend the Code. The proposal in this paper will be considered at the <span class="hlt">IBC</span> in Shenzh...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/publication/?seqNo115=328618','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/publication/?seqNo115=328618"><span>(000) A proposal concerning the valid publication of suprageneric “autonyms”</span></a></p> <p><a target="_blank" href="https://www.ars.usda.gov/research/publications/find-a-publication/">USDA-ARS?s Scientific Manuscript database</a></p> <p></p> <p></p> <p>The International Code of Nomenclature for algae, fungi and plants is revised every six years to incorporate decisions of the Nomenclature Section of successive International Botanical Congresses (<span class="hlt">IBC</span>) on proposals to amend the Code. The proposal in this paper will be considered at the <span class="hlt">IBC</span> in Shenzh...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/publication/?seqNo115=328417','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/publication/?seqNo115=328417"><span>(001–008) Some proposals to resolve problems relating to the conservation or rejection of names, suppression of works, and binding decisions</span></a></p> <p><a target="_blank" href="https://www.ars.usda.gov/research/publications/find-a-publication/">USDA-ARS?s Scientific Manuscript database</a></p> <p></p> <p></p> <p>The International Code of Nomenclature for algae, fungi and plants is revised every six years to incorporate decisions of the Nomenclature Section of successive International Botanical Congresses (<span class="hlt">IBC</span>) on proposals to amend the Code. The proposals in this paper will be considered at the <span class="hlt">IBC</span> in Shenz...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/publication/?seqNo115=331420','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/publication/?seqNo115=331420"><span>(390) Proposal to preclude homonymy of generic names with names of intergeneric graft-hybrids (chimaeras)</span></a></p> <p><a target="_blank" href="https://www.ars.usda.gov/research/publications/find-a-publication/">USDA-ARS?s Scientific Manuscript database</a></p> <p></p> <p></p> <p>The International Code of Nomenclature for algae, fungi and plants is revised every six years to incorporate decisions of the Nomenclature Section of successive International Botanical Congresses (<span class="hlt">IBC</span>) on proposals to amend the Code. The proposal in this paper will be considered at the <span class="hlt">IBC</span> in Shenzh...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/publication/?seqNo115=330534','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/publication/?seqNo115=330534"><span>(001) A proposal relating to infraspecific names (Art. 24)</span></a></p> <p><a target="_blank" href="https://www.ars.usda.gov/research/publications/find-a-publication/">USDA-ARS?s Scientific Manuscript database</a></p> <p></p> <p></p> <p>The International Code of Nomenclature for algae, fungi and plants is revised every six years to incorporate decisions of the Nomenclature Section of successive International Botanical Congresses (<span class="hlt">IBC</span>) on proposals to amend the Code. The proposal in this paper will be considered at the <span class="hlt">IBC</span> in Shenzh...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2013-03-07/pdf/2013-04197.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2013-03-07/pdf/2013-04197.pdf"><span>78 FR 14702 - Hazardous Materials: Miscellaneous Petitions for Rulemaking (RRR)</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2013-03-07</p> <p>... Standard Specification for Polyethylene Plastics Molding and Extrusion Materials to provide a range of acceptable resin tolerances in the plastic drum and <span class="hlt">IBC</span> material; Allow smokeless powder classed as a... incorporate by reference ASTM Standard 04976-06 without stating that plastic drums and <span class="hlt">IBCs</span> made from...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014PhyC..504..127K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014PhyC..504..127K"><span><span class="hlt">Design</span> and manufacture of a D-shape coil-based toroid-<span class="hlt">type</span> HTS DC reactor using 2nd generation HTS wire</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kim, Kwangmin; Go, Byeong-Soo; Sung, Hae-Jin; Park, Hea-chul; Kim, Seokho; Lee, Sangjin; Jin, Yoon-Su; Oh, Yunsang; Park, Minwon; Yu, In-Keun</p> <p>2014-09-01</p> <p>This paper describes the <span class="hlt">design</span> specifications and performance of a real toroid-<span class="hlt">type</span> high temperature superconducting (HTS) DC reactor. The HTS DC reactor was <span class="hlt">designed</span> using 2G HTS wires. The HTS coils of the toroid-<span class="hlt">type</span> DC reactor magnet were made in the form of a D-shape. The target inductance of the HTS DC reactor was 400 mH. The expected operating temperature was under 20 K. The electromagnetic performance of the toroid-<span class="hlt">type</span> HTS DC reactor magnet was analyzed using the finite element method program. A conduction cooling method was adopted for reactor magnet cooling. Performances of the toroid-<span class="hlt">type</span> HTS DC reactor were analyzed through experiments conducted under the steady-state and charge conditions. The fundamental <span class="hlt">design</span> specifications and the data obtained from this research will be applied to the <span class="hlt">design</span> of a commercial-<span class="hlt">type</span> HTS DC reactor.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1375116','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1375116"><span>Micro Calorimeter for Batteries</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Santhanagopalan, Shriram</p> <p>2017-08-01</p> <p>As battery technology forges ahead and consumer demand for safer, more affordable, high-performance batteries grows, the National Renewable Energy Laboratory (NREL) has added a patented Micro Calorimeter to its existing family of R&D 100 Award-winning Isothermal Battery Calorimeters (<span class="hlt">IBCs</span>). The Micro Calorimeter examines the thermal signature of battery chemistries early on in the <span class="hlt">design</span> cycle using popular coin cell and small pouch cell <span class="hlt">designs</span>, which are simple to fabricate and study.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28560598','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28560598"><span>The Impact of Residual Disease After Preoperative Systemic Therapy on Clinical Outcomes in Patients with Inflammatory Breast Cancer.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Nakhlis, Faina; Regan, Meredith M; Warren, Laura E; Bellon, Jennifer R; Hirshfield-Bartek, Judith; Duggan, Margaret M; Dominici, Laura S; Golshan, Mehra; Jacene, Heather A; Yeh, Eren D; Mullaney, Erin E; Overmoyer, Beth</p> <p>2017-09-01</p> <p>Inflammatory breast cancer (<span class="hlt">IBC</span>) is a rare and aggressive disease treated with multimodality therapy: preoperative systemic therapy (PST) followed by modified radical mastectomy (MRM), chest wall and regional nodal radiotherapy, and adjuvant biologic therapy and/or endocrine therapy when appropriate. In non-<span class="hlt">IBC</span>, the degree of pathologic response to PST has been shown to correlate with time to recurrence (TTR) and overall survival (OS). We sought to determine if pathologic response correlates with oncologic outcomes of <span class="hlt">IBC</span> patients. Following review of <span class="hlt">IBC</span> patients' records (1997-2014), we identified 258 stage III <span class="hlt">IBC</span> patients; 181 received PST followed by MRM and radiotherapy and were subsequently analyzed. Pathologic complete response (pCR) to PST, hormone receptor and human epidermal growth factor receptor 2 (HER2) status, grade, and histology were evaluated as predictors of TTR and OS by Cox model. Overall, 95/181 (52%) patients experienced recurrence; 93/95 (98%) were distant metastases (median TTR 3.2 years). Seventy-three patients (40%) died (median OS 6.9 years). pCR was associated with improved TTR (hazard ratio [HR] 0.20, 95% confidence interval [CI] 0.09-0.46, p < 0.01, univariate; HR 0.17, 95% CI 0.07-0.41, p < 0.0001, multivariate) and improved OS (HR 0.26, 95% CI 0.11-0.65, p < 0.01, univariate). In patients with pCR, grade III (HR 1.91, 95% CI 1.16-3.13, p = 0.01), and triple-negative phenotype (HR 3.54, 95% CI 1.79-6.98, p = 0.0003) were associated with shorter TTR, while residual ductal carcinoma in situ was not (HR 0.85, 95% CI 0.53-1.35, p = 0.48, multivariate). In stage III <span class="hlt">IBC</span>, pCR was associated with prognosis, further influenced by grade, hormone receptor, and HER2 status. Investigating mechanisms that contribute to better response to PST could help improve oncologic outcomes in <span class="hlt">IBC</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19671005','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19671005"><span>Characterization of hypersensitive resistance to bacterial spot race T3 (Xanthomonas perforans) from tomato accession PI 128216.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Robbins, Matthew D; Darrigues, Audrey; Sim, Sung-Chur; Masud, Mohammed Abu Taher; Francis, David M</p> <p>2009-09-01</p> <p>Bacterial spot of tomato is caused by four species of Xanthomonas. The accession PI 128216 (Solanum pimpinellifolium) displays a hypersensitive reaction (HR) to race T3 strains (predominantely Xanthomonas perforans). We developed an inbred backcross (<span class="hlt">IBC</span>) population (BC(2)S(5), 178 families) derived from PI 128216 and OH88119 (S. lycopersicum) as the susceptible recurrent parent for simultaneous introgression and genetic analysis of the HR response. These <span class="hlt">IBC</span> families were evaluated in the greenhouse for HR to race T3 strain Xcv761. The <span class="hlt">IBC</span> population was genotyped with molecular markers distributed throughout the genome in order to identify candidate loci conferring resistance. We treated the <span class="hlt">IBC</span> population as a hypothesis forming generation to guide validation in subsequent crosses. Nonparametric analysis identified an association between HR and markers clustered on chromosome 11 (P < 0.05 to 0.0001) and chromosome 6 (0.04 > P > 0.002). Further analysis of the <span class="hlt">IBC</span> population suggested that markers on chromosome 6 and 11 failed to assort independently, a phenomenon known as gametic phase disequilibrium. Therefore, to validate marker-trait linkages, resistant <span class="hlt">IBC</span> plants were crossed with OH88119 and BC(3)F(2) progeny were evaluated for HR in the greenhouse. In these subsequent populations, the HR response was associated with the chromosome 11 markers (P < 0.0002) but not with the markers on chromosome 6 (P > 0.25). Independent F(2) families were developed by crossing resistant <span class="hlt">IBC</span> lines to OH8245, OH88119, and OH7530. These populations were genotyped, organized into classes based on chromosome 11 markers, and evaluated for resistance in the field. The PI 128216 locus on chromosome 11 provided resistance that was dependent on gene dosage and genetic background. These results define a single locus, Rx-4, from PI 128216, which provides resistance to bacterial spot race T3, has additive gene action, and is located on chromosome 11.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li class="active"><span>16</span></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_16 --> <div id="page_17" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li class="active"><span>17</span></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="321"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25091303','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25091303"><span>Intracellular bacteria in the pathogenesis of Escherichia coli urinary tract infection in children.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Robino, Luciana; Scavone, Paola; Araujo, Lucia; Algorta, Gabriela; Zunino, Pablo; Pírez, María Catalina; Vignoli, Rafael</p> <p>2014-12-01</p> <p>Uropathogenic Escherichia coli (UPEC) is the most common agent of urinary tract infection (UTI). The classic model of pathogenesis proposes the ascent of UPEC by the urethra and external adherence to the urothelium. Recently, the ability of UPEC to invade urothelial cells and to form intracellular bacterial communities (<span class="hlt">IBCs</span>) has been described. The objective of the present study was to determine the presence of intracellular bacteria (IB) in children with UTI caused by E. coli and to characterize its virulence attributes and its relation with clinical outcomes. One hundred thirty-three children with E. coli UTI who attended a reference children's hospital between June and November 2012 were included. Urine samples were analyzed by optical and confocal microscopy looking for exfoliated urothelial cells with IB. Phylogenetic group and 24 virulence factors of UPEC were determined using multiplex polymerase chain reaction. Medical records were analyzed. The presence of IB was detected in 49 of 133 (36.8%) samples by confocal microscopy, in 30 cases as <span class="hlt">IBC</span>, and in 19 as isolated intracellular bacteria (IIB). Only 50% of these cases could be detected by light microscopy. Seventy-four medical records were analyzed, 34 with <span class="hlt">IBC</span>/IIB, 40 without IB. Any virulence gene was associated with <span class="hlt">IBC</span>/IIB. The presence of <span class="hlt">IBC</span>/IIB was associated with recurrent UTI (odds ratio [OR], 3.3; 95% confidence interval [CI], 1.3-9; P = .017), especially in children without urinary tract functional or morphological abnormalities (OR, 8.0; 95% CI, 2.3-27.4; P = .000). <span class="hlt">IBCs</span> were associated with lower urinary tract syndrome (OR, 3.6; 95% CI, 1.1-11.8; P = .05) and absence of fever (P = .009). <span class="hlt">IBCs</span>/IIB could explain a high proportion of children with recurrent UTI. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5456900','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5456900"><span>Hard-Rock Stability Analysis for Span <span class="hlt">Design</span> in Entry-<span class="hlt">Type</span> Excavations with Learning Classifiers</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>García-Gonzalo, Esperanza; Fernández-Muñiz, Zulima; García Nieto, Paulino José; Bernardo Sánchez, Antonio; Menéndez Fernández, Marta</p> <p>2016-01-01</p> <p>The mining industry relies heavily on empirical analysis for <span class="hlt">design</span> and prediction. An empirical <span class="hlt">design</span> method, called the critical span graph, was developed specifically for rock stability analysis in entry-<span class="hlt">type</span> excavations, based on an extensive case-history database of cut and fill mining in Canada. This empirical span <span class="hlt">design</span> chart plots the critical span against rock mass rating for the observed case histories and has been accepted by many mining operations for the initial span <span class="hlt">design</span> of cut and fill stopes. Different <span class="hlt">types</span> of analysis have been used to classify the observed cases into stable, potentially unstable and unstable groups. The main purpose of this paper is to present a new method for defining rock stability areas of the critical span graph, which applies machine learning classifiers (support vector machine and extreme learning machine). The results show a reasonable correlation with previous guidelines. These machine learning methods are good tools for developing empirical methods, since they make no assumptions about the regression function. With this software, it is easy to add new field observations to a previous database, improving prediction output with the addition of data that consider the local conditions for each mine. PMID:28773653</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28773653','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28773653"><span>Hard-Rock Stability Analysis for Span <span class="hlt">Design</span> in Entry-<span class="hlt">Type</span> Excavations with Learning Classifiers.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>García-Gonzalo, Esperanza; Fernández-Muñiz, Zulima; García Nieto, Paulino José; Bernardo Sánchez, Antonio; Menéndez Fernández, Marta</p> <p>2016-06-29</p> <p>The mining industry relies heavily on empirical analysis for <span class="hlt">design</span> and prediction. An empirical <span class="hlt">design</span> method, called the critical span graph, was developed specifically for rock stability analysis in entry-<span class="hlt">type</span> excavations, based on an extensive case-history database of cut and fill mining in Canada. This empirical span <span class="hlt">design</span> chart plots the critical span against rock mass rating for the observed case histories and has been accepted by many mining operations for the initial span <span class="hlt">design</span> of cut and fill stopes. Different <span class="hlt">types</span> of analysis have been used to classify the observed cases into stable, potentially unstable and unstable groups. The main purpose of this paper is to present a new method for defining rock stability areas of the critical span graph, which applies machine learning classifiers (support vector machine and extreme learning machine). The results show a reasonable correlation with previous guidelines. These machine learning methods are good tools for developing empirical methods, since they make no assumptions about the regression function. With this software, it is easy to add new field observations to a previous database, improving prediction output with the addition of data that consider the local conditions for each mine.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4667996','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4667996"><span>Usage Position and Virtual Keyboard <span class="hlt">Design</span> Affect Upper-Body Kinematics, Discomfort, and Usability during Prolonged Tablet <span class="hlt">Typing</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Lin, Ming-I Brandon; Hong, Ruei-Hong; Chang, Jer-Hao; Ke, Xin-Min</p> <p>2015-01-01</p> <p>Purpose The increase in tablet usage allows people to perform computer work in non-traditional office environments. The aim of this study was to assess the effects of changes in tablet keyboard <span class="hlt">design</span> on postures of the upper extremities and neck, discomfort, and usability under different usage positions during prolonged touch-<span class="hlt">typing</span>. Methods Eighteen healthy participants familiar with touch-screen devices were randomized into three usage positions (desk, lap, and bed) and completed six, 60-minute <span class="hlt">typing</span> sessions using three virtual keyboard <span class="hlt">designs</span> (standard, wide, split). Electrogoniometers continuously measured the postures of the wrists, elbow, and neck. Body discomfort and system usability were evaluated by questionnaires before and immediately after each <span class="hlt">typing</span> session. Results Separate linear mixed effects models on various postural measures and subjective ratings are conducted with usage position as the between-subject factors, keyboard <span class="hlt">design</span> and <span class="hlt">typing</span> duration as the with-in subject factors were conducted. Using the tablet in bed led to more extended wrists but a more natural elbow flexion than the desk position. The angled split virtual keyboard significantly reduced the extent of wrist ulnar deviation than the keyboard with either standard or wide <span class="hlt">design</span>. However, little difference was observed across the usage position and keyboard <span class="hlt">design</span>. When the postural data were compared between the middle and end of <span class="hlt">typing</span> sessions, the wrists, elbow, and neck all exhibited a substantially increased range of joint movements (13% to 38%). The discomfort rating also increased significantly over time in every upper body region investigated. Additionally, the split keyboard <span class="hlt">design</span> received a higher usability rating in the bed position, whereas participants had more satisfactory experience while using the wide keyboard in the traditional desk setting. Conclusions Prolonged use of tablets in non-traditional office environments may result in awkward postures in the</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED545192.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED545192.pdf"><span>Macro-Environmental Mapping of International Branch Campus Activities of Universities Worldwide. Research & Occasional Paper Series: CSHE.2.14</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Kosmützky, Anna; Krücken, Georg</p> <p>2014-01-01</p> <p>The paper provides an initial international comparative empirical assessment of international branch campuses (<span class="hlt">IBCs</span>) worldwide. Building on neo-institutional theory and organizational ecology, it sheds light on the new organizational form by analyzing their founding age of the home university and <span class="hlt">IBC</span> mortality. Furthermore the paper analyzes the…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19482582','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19482582"><span>Reinforcement interval <span class="hlt">type</span>-2 fuzzy controller <span class="hlt">design</span> by online rule generation and q-value-aided ant colony optimization.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Juang, Chia-Feng; Hsu, Chia-Hung</p> <p>2009-12-01</p> <p>This paper proposes a new reinforcement-learning method using online rule generation and Q-value-aided ant colony optimization (ORGQACO) for fuzzy controller <span class="hlt">design</span>. The fuzzy controller is based on an interval <span class="hlt">type</span>-2 fuzzy system (IT2FS). The antecedent part in the <span class="hlt">designed</span> IT2FS uses interval <span class="hlt">type</span>-2 fuzzy sets to improve controller robustness to noise. There are initially no fuzzy rules in the IT2FS. The ORGQACO concurrently <span class="hlt">designs</span> both the structure and parameters of an IT2FS. We propose an online interval <span class="hlt">type</span>-2 rule generation method for the evolution of system structure and flexible partitioning of the input space. Consequent part parameters in an IT2FS are <span class="hlt">designed</span> using Q -values and the reinforcement local-global ant colony optimization algorithm. This algorithm selects the consequent part from a set of candidate actions according to ant pheromone trails and Q-values, both of which are updated using reinforcement signals. The ORGQACO <span class="hlt">design</span> method is applied to the following three control problems: 1) truck-backing control; 2) magnetic-levitation control; and 3) chaotic-system control. The ORGQACO is compared with other reinforcement-learning methods to verify its efficiency and effectiveness. Comparisons with <span class="hlt">type</span>-1 fuzzy systems verify the noise robustness property of using an IT2FS.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015PhFl...27c5107S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015PhFl...27c5107S"><span>Compressible turbulent channel flow with impedance boundary conditions</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Scalo, Carlo; Bodart, Julien; Lele, Sanjiva K.</p> <p>2015-03-01</p> <p>We have performed large-eddy simulations of isothermal-wall compressible turbulent channel flow with linear acoustic impedance boundary conditions (<span class="hlt">IBCs</span>) for the wall-normal velocity component and no-slip conditions for the tangential velocity components. Three bulk Mach numbers, Mb = 0.05, 0.2, 0.5, with a fixed bulk Reynolds number, Reb = 6900, have been investigated. For each Mb, nine different combinations of <span class="hlt">IBC</span> settings were tested, in addition to a reference case with impermeable walls, resulting in a total of 30 simulations. The adopted numerical coupling strategy allows for a spatially and temporally consistent imposition of physically realizable <span class="hlt">IBCs</span> in a fully explicit compressible Navier-Stokes solver. The <span class="hlt">IBCs</span> are formulated in the time domain according to Fung and Ju ["Time-domain impedance boundary conditions for computational acoustics and aeroacoustics," Int. J. Comput. Fluid Dyn. 18(6), 503-511 (2004)]. The impedance adopted is a three-parameter damped Helmholtz oscillator with resonant angular frequency, ωr, tuned to the characteristic time scale of the large energy-containing eddies. The tuning condition, which reads ωr = 2πMb (normalized with the speed of sound and channel half-width), reduces the <span class="hlt">IBCs</span>' free parameters to two: the damping ratio, ζ, and the resistance, R, which have been varied independently with values, ζ = 0.5, 0.7, 0.9, and R = 0.01, 0.10, 1.00, for each Mb. The application of the tuned <span class="hlt">IBCs</span> results in a drag increase up to 300% for Mb = 0.5 and R = 0.01. It is shown that for tuned <span class="hlt">IBCs</span>, the resistance, R, acts as the inverse of the wall-permeability and that varying the damping ratio, ζ, has a secondary effect on the flow response. Typical buffer-layer turbulent structures are completely suppressed by the application of tuned <span class="hlt">IBCs</span>. A new resonance buffer layer is established characterized by large spanwise-coherent Kelvin-Helmholtz rollers, with a well-defined streamwise wavelength λx, traveling downstream with</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20150005894&hterms=Design+Low-Noise+Amplifiers&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3DThe%2BDesign%2BLow-Noise%2BAmplifiers','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20150005894&hterms=Design+Low-Noise+Amplifiers&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3DThe%2BDesign%2BLow-Noise%2BAmplifiers"><span>Project Report: <span class="hlt">Design</span> and Analysis for the Deep Space Network BWG <span class="hlt">Type</span> 2 Antenna Feed Platform</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Crawford, Andrew</p> <p>2011-01-01</p> <p>The following report explains in detail the solid modeling <span class="hlt">design</span> process and structural analysis of the LNA (Low Noise Amplifier) feed platform to be constructed and installed on the new BWG (Beam Wave Guide) <span class="hlt">Type</span>-2 tracking antenna in Canberra, Australia, as well as all future similar BWG <span class="hlt">Type</span>-2 antennas builds. The Deep Space Networks new BWG <span class="hlt">Type</span>-2 antennas use beam waveguides to funnel and 'extract' the desired signals received from spacecraft, and the feed platform supports and houses the LNA(Low Noise Amplifier) feed-cone and cryogenic cooling equipment used in the signal transmission and receiving process. The mandated <span class="hlt">design</span> and construction of this platform to be installed on the new tracking antenna will be used and incorporated on all future similar antenna builds.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=radar&pg=4&id=EJ946025','ERIC'); return false;" href="https://eric.ed.gov/?q=radar&pg=4&id=EJ946025"><span>The Cross-Border Education Policy Context: Educational Hubs, Trade Liberalization, and National Sovereignty</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Lane, Jason E.; Kinser, Kevin</p> <p>2011-01-01</p> <p>International branch campuses (<span class="hlt">IBCs</span>) operate in national and international policy environments that are still rapidly evolving. While <span class="hlt">IBCs</span> have been operating for several decades, most of that time they have operated below the domestic regulatory radar of either the exporting (home) or importing (host) governments. As the number of such…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=business+AND+disciplinary+AND+process&pg=3&id=EJ570696','ERIC'); return false;" href="https://eric.ed.gov/?q=business+AND+disciplinary+AND+process&pg=3&id=EJ570696"><span>The Execution and Evaluation of an Integrated Business Common Core Curriculum.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Pharr, Steven W.; Morris, John S.; Stover, Dana; Byers, C. Randall; Reyes, Mario G.</p> <p>1998-01-01</p> <p>Describes the rationale, process, and organization of an integrated, cross-disciplinary undergraduate program known as the Integrated Business Common Core (<span class="hlt">IBC</span>) at the University of Idaho. Indicates that <span class="hlt">IBC</span>'s goal is to provide students with an understanding of key business issues, with emphasis on processes. (2 tables and 11 references) (JDI)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=%22Operations+Management%22&pg=7&id=EJ946024','ERIC'); return false;" href="https://eric.ed.gov/?q=%22Operations+Management%22&pg=7&id=EJ946024"><span>Operational Considerations for Opening a Branch Campus Abroad</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Harding, Lawrence M.; Lammey, Robert W.</p> <p>2011-01-01</p> <p>Universities have been attracted to the creation of international branch campuses (<span class="hlt">IBCs</span>) for many reasons, including cultural immersion of students and faculty and global brand recognition for a university seeking to enhance its reputation and strengthen its academic standards. This chapter provides specific advice for how <span class="hlt">IBCs</span> can negotiate entry…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24992172','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24992172"><span>Reduced MUC4 expression is a late event in breast carcinogenesis and is correlated with increased infiltration of immune cells as well as promoter hypermethylation in invasive breast carcinoma.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Cho, Jin Seong; Park, Min Ho; Lee, Ji Shin; Yoon, Jung Han</p> <p>2015-01-01</p> <p>Altered expression of MUC4 is associated with tumor progression and immune surveillance, but the potential involvement of MUC4 in breast carcinogenesis has not been rigorously assessed. Immunohistochemical staining with anti-MUC4 antibody was performed in a total of 324 patients with 26 normal breasts, 25 usual ductal hyperplasia, 76 ductal carcinoma in situ, and 198 invasive breast carcinoma (<span class="hlt">IBC</span>) using tissue microarray. Immunohistochemical staining for CD8, CD57, and CD1a and methylation-specific polymerase chain reaction were also performed in <span class="hlt">IBC</span>. Reduced MUC4 expression in <span class="hlt">IBC</span> was significantly higher than in usual ductal hyperplasia and ductal carcinoma in situ (P<0.001 and P<0.01, respectively). Reduced MUC4 expression in <span class="hlt">IBC</span> was significantly correlated with promoter hypermethylation (P<0.05). No association between MUC4 expression and patient outcomes was identified. Intratumoral CD8 T cells and stromal CD57 natural killer cells were significantly increased in the reduced MUC4 expression group compared with those in the normal expression group (P<0.01 and P<0.05, respectively). Our results suggest that tumor progression in breast epithelium is accompanied by reduced MUC4 protein expression. Reduced MUC4 expression correlates with increased tumor-infiltrating CD8 T and NK cells as well as promoter hypermethylation in <span class="hlt">IBC</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title7-vol3/pdf/CFR-2014-title7-vol3-sec201-34.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title7-vol3/pdf/CFR-2014-title7-vol3-sec201-34.pdf"><span>7 CFR 201.34 - Kind, variety, and <span class="hlt">type</span>; treatment substances; <span class="hlt">designation</span> as hybrid.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-01-01</p> <p>... date. The variety name for any variety of hybrid seed corn first introduced into commercial channels in... AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Labeling in General § 201.34 Kind, variety, and <span class="hlt">type</span>; treatment substances; <span class="hlt">designation</span> as hybrid. (a) Indistinguishable seed and treatment...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title7-vol3/pdf/CFR-2013-title7-vol3-sec201-34.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title7-vol3/pdf/CFR-2013-title7-vol3-sec201-34.pdf"><span>7 CFR 201.34 - Kind, variety, and <span class="hlt">type</span>; treatment substances; <span class="hlt">designation</span> as hybrid.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-01-01</p> <p>... date. The variety name for any variety of hybrid seed corn first introduced into commercial channels in... AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Labeling in General § 201.34 Kind, variety, and <span class="hlt">type</span>; treatment substances; <span class="hlt">designation</span> as hybrid. (a) Indistinguishable seed and treatment...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title7-vol3/pdf/CFR-2012-title7-vol3-sec201-34.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title7-vol3/pdf/CFR-2012-title7-vol3-sec201-34.pdf"><span>7 CFR 201.34 - Kind, variety, and <span class="hlt">type</span>; treatment substances; <span class="hlt">designation</span> as hybrid.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-01-01</p> <p>... date. The variety name for any variety of hybrid seed corn first introduced into commercial channels in... AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Labeling in General § 201.34 Kind, variety, and <span class="hlt">type</span>; treatment substances; <span class="hlt">designation</span> as hybrid. (a) Indistinguishable seed and treatment...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016AIPC.1722n0010G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016AIPC.1722n0010G"><span>A button - <span class="hlt">type</span> beam position monitor <span class="hlt">design</span> for TARLA facility</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Gündoǧan, M. Tural; Kaya, ć.; Yavaş, Ö.</p> <p>2016-03-01</p> <p>Turkish Accelerator and Radiation Laboratory in Ankara (TARLA) facility is proposed as an IR FEL and Bremsstrahlung facility as the first facility of Turkish Accelerator Center (TAC). TARLA is essentially proposed to generate oscillator mode FEL in 3-250 microns wavelengths range, will consist of normal conducting injector system with 250 keV beam energy, two superconducting RF accelerating modules in order to accelerate the beam 15-40 MeV. The TARLA facility is expected to provide two modes, Continuous wave (CW) and pulsed mode. Longitudinal electron bunch length will be changed between 1 and 10 ps. The bunch charge will be limited by 77pC. The <span class="hlt">design</span> of the Button-<span class="hlt">type</span> Beam Position Monitor for TARLA IR FEL is studied to operate in 1.3 GHz. Mechanical antenna <span class="hlt">design</span> and simulations are completed considering electron beam parameters of TARLA. Ansoft HFSS and CST Particle Studio is used to compare with results of simulations.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017hst..prop15152V','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017hst..prop15152V"><span>Finally, the Progenitor of the <span class="hlt">Type</span> Ib iPTF13bvn</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Van Dyk, Schulyer</p> <p>2017-08-01</p> <p>Supernovae (SNe) are among the most powerful events in the Universe and have a profound influence on galaxy evolution. Whereas we have been able to identify the luminous red supergiant progenitor stars of the most common core-collapse explosions, the hydrogen-rich <span class="hlt">Type</span> II, the progenitors of hydrogen-poor <span class="hlt">Type</span> Ib and <span class="hlt">Type</span> Ic have been far more elusive. To strip away a SN <span class="hlt">Ib/c</span> progenitor's outer layers, theoretical models with either (a) a highly-massive star with prodigious winds during the Wolf-Rayet phase or (b) a somewhat lower-mass star in a close, mass-exchange binary system have been proposed. One example exists so far of a progenitor identification, for the SN Ib iPTF13bvn in NGC 5806. Both models have been invoked to explain this event, although most evidence to date points toward the binary model. Our combined team observed this SN with WFC3 in Cycle 22, about 2 years after explosion, to investigate whether the progenitor had disappeared. As a result, we were able to report that indeed it had. We also attempted to better characterize the nature of the progenitor by subtracting our images from the pre-explosion HST data. Unfortunately, the old SN was apparently still conspicuously present. We therefore propose to reimage the SN site, when the SN should then be well below detectability, to produce high-quality templates of the host galaxy for subtraction. We can then finally fully reveal the progenitor and understand its true nature. iPTF13bvn is one of the most important historical SNe and will most probably be the best available case of a SN Ib progenitor for HST's remaining lifetime. It is imperative to understand the nature of this SN and its progenitor object.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24007056','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24007056"><span>A new <span class="hlt">design</span> of indirectly heated cathode based strip <span class="hlt">type</span> electron gun.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Maiti, Namita; Lijeesh, K; Barve, U D; Quadri, Nishad; Tembhare, G U; Mukherjee, S; Thakur, K B; Das, A K</p> <p>2013-08-01</p> <p>A new <span class="hlt">design</span> of indirectly heated solid cathode based electron gun (200 kW, 45 kV, 270° bent strip <span class="hlt">type</span> electron gun) has been presented. The <span class="hlt">design</span> issue addressed is the uniformity of temperature on the solid cathode using (a) a multi-segmented filament with variable height as the primary heat source and (b) trapezoidal shaped single long filament as the primary heat source. The proposed <span class="hlt">design</span> in this paper is based on computer simulation and validated by extensive experimentations. The <span class="hlt">design</span> emphasis is on maintaining uniform temperature on the solid cathode. The <span class="hlt">designed</span> multi-segment filament and the single long filament provide a temperature uniformity on the solid cathode of about 250 K and 110 K, respectively. The better temperature uniformity inspite of the thermal expansion, in case of a single long filament tightly clamped at two ends, has been possible due to shaping of the single filament with a number of constituent sections such that the thermal expansion of different sections forming the actual filament takes care of not only the mechanical stability but also does not affect the emitting surface of the filament. Experiments show that the modified <span class="hlt">design</span> achieves a one to one correspondence of the solid cathode length and the electron beam length emitted from the solid cathode.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol2/pdf/CFR-2010-title49-vol2-sec178-814.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol2/pdf/CFR-2010-title49-vol2-sec178-814.pdf"><span>49 CFR 178.814 - Hydrostatic pressure test.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... 49 Transportation 2 2010-10-01 2010-10-01 false Hydrostatic pressure test. 178.814 Section 178.814... Testing of <span class="hlt">IBCs</span> § 178.814 Hydrostatic pressure test. (a) General. The hydrostatic pressure test must be... preparation for the hydrostatic pressure test. For metal <span class="hlt">IBCs</span>, the test must be carried out before the fitting...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol2/pdf/CFR-2010-title49-vol2-sec178-815.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol2/pdf/CFR-2010-title49-vol2-sec178-815.pdf"><span>49 CFR 178.815 - Stacking test.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... for transportation, and no loss of contents. (2) For fiberboard and wooden <span class="hlt">IBCs</span>, there may be no loss... unsafe for transportation, and no loss of contents. (4) For the dynamic compression test, a container passes the test if, after application of the required load, there is no permanent deformation to the <span class="hlt">IBC</span>...</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li class="active"><span>17</span></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_17 --> <div id="page_18" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li class="active"><span>18</span></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="341"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title7-vol3/pdf/CFR-2011-title7-vol3-sec201-34.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title7-vol3/pdf/CFR-2011-title7-vol3-sec201-34.pdf"><span>7 CFR 201.34 - Kind, variety, and <span class="hlt">type</span>; treatment substances; <span class="hlt">designation</span> as hybrid.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-01-01</p> <p>... and the shipment of the seed in interstate commerce, or (2) dormancy of the seeds in the lot, or (3... AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Labeling in General § 201.34 Kind, variety, and <span class="hlt">type</span>; treatment substances; <span class="hlt">designation</span> as hybrid. (a) Indistinguishable seed and treatment...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23575266','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23575266"><span><span class="hlt">IBC</span>'s 23rd Annual Antibody Engineering, 10th Annual Antibody Therapeutics international conferences and the 2012 Annual Meeting of The Antibody Society: December 3-6, 2012, San Diego, CA.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Klöhn, Peter-Christian; Wuellner, Ulrich; Zizlsperger, Nora; Zhou, Yu; Tavares, Daniel; Berger, Sven; Zettlitz, Kirstin A; Proetzel, Gabriele; Yong, May; Begent, Richard H J; Reichert, Janice M</p> <p>2013-01-01</p> <p>The 23rd Annual Antibody Engineering, 10th Annual Antibody Therapeutics international conferences, and the 2012 Annual Meeting of The Antibody Society, organized by <span class="hlt">IBC</span> Life Sciences with contributions from The Antibody Society and two Scientific Advisory Boards, were held December 3-6, 2012 in San Diego, CA. The meeting drew over 800 participants who attended sessions on a wide variety of topics relevant to antibody research and development. As a prelude to the main events, a pre-conference workshop held on December 2, 2012 focused on intellectual property issues that impact antibody engineering. The Antibody Engineering Conference was composed of six sessions held December 3-5, 2012: (1) From Receptor Biology to Therapy; (2) Antibodies in a Complex Environment; (3) Antibody Targeted CNS Therapy: Beyond the Blood Brain Barrier; (4) Deep Sequencing in B Cell Biology and Antibody Libraries; (5) Systems Medicine in the Development of Antibody Therapies/Systematic Validation of Novel Antibody Targets; and (6) Antibody Activity and Animal Models. The Antibody Therapeutics conference comprised four sessions held December 4-5, 2012: (1) Clinical and Preclinical Updates of Antibody-Drug Conjugates; (2) Multifunctional Antibodies and Antibody Combinations: Clinical Focus; (3) Development Status of Immunomodulatory Therapeutic Antibodies; and (4) Modulating the Half-Life of Antibody Therapeutics. The Antibody Society's special session on applications for recording and sharing data based on GIATE was held on December 5, 2012, and the conferences concluded with two combined sessions on December 5-6, 2012: (1) Development Status of Early Stage Therapeutic Antibodies; and (2) Immunomodulatory Antibodies for Cancer Therapy.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018IJSS...49..435W','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018IJSS...49..435W"><span><span class="hlt">Design</span> of distributed PID-<span class="hlt">type</span> dynamic matrix controller for fractional-order systems</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Wang, Dawei; Zhang, Ridong</p> <p>2018-01-01</p> <p>With the continuous requirements for product quality and safety operation in industrial production, it is difficult to describe the complex large-scale processes with integer-order differential equations. However, the fractional differential equations may precisely represent the intrinsic characteristics of such systems. In this paper, a distributed PID-<span class="hlt">type</span> dynamic matrix control method based on fractional-order systems is proposed. First, the high-order approximate model of integer order is obtained by utilising the Oustaloup method. Then, the step response model vectors of the plant is obtained on the basis of the high-order model, and the online optimisation for multivariable processes is transformed into the optimisation of each small-scale subsystem that is regarded as a sub-plant controlled in the distributed framework. Furthermore, the PID operator is introduced into the performance index of each subsystem and the fractional-order PID-<span class="hlt">type</span> dynamic matrix controller is <span class="hlt">designed</span> based on Nash optimisation strategy. The information exchange among the subsystems is realised through the distributed control structure so as to complete the optimisation task of the whole large-scale system. Finally, the control performance of the <span class="hlt">designed</span> controller in this paper is verified by an example.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015IAUGA..2257983W','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015IAUGA..2257983W"><span>SOFIA Observations of the <span class="hlt">Type</span> IIn Supernova 2010jl</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Williams, Brian J.; Fox, Ori D.</p> <p>2015-08-01</p> <p>We present results from SOFIA mid-infrared (IR) observations of the recent <span class="hlt">Type</span> IIn supernova (SN IIn) 2010jl. SNe IIn, named for their relatively narrow emission lines, are a somewhat rare subclass of SNe, composing less than 10% of all core-collapse events. However, they account for more than half of all known SNe with late-time (> 100 days) infrared excess, implying the presence of warm dust. Their narrow lines are formed in the interaction of the ejecta with a dense, slowly moving, pre-existing circumstellar medium (CSM), implying extraordinarily mass loss rates (as high as a tenth of a solar mass per year). Fox et al. (2011) showed, via a warm-mission Spitzer survey of SNe IIn, that the observed IR emission is consistent with pre-existing CSM dust, heated by the optical emission generated by the interaction of the forward shock with the dense CSM, and not from ejecta dust like most core-collapse SNe. Characterizing this dust reveals unique information about the pre-SN environment and the mass-loss history of the progenitor. A key question involves the <span class="hlt">type</span> of dust grain, silicates or carbonaceous, formed in the pre-SN wind.Most proposed progenitors for SNe IIn (red supergiants, luminous blue variables, yellow hypergiants, and B[e] supergiants) show silicate dust in their pre-SN outflows. Carbonaceous dust grains are only observed in the outflows from Wolf-Rayet stars, which have a much lower mass rate and are generally believed to explode as <span class="hlt">Type</span> <span class="hlt">Ib/c</span> SNe, and not <span class="hlt">Type</span> IIn. With only Spitzer data, it is impossible to distinguish between silicate and carbonaceous dust grains. However, the strong 9.7 micron silicate feature would show up in mid-IR observations. SN 2010jl was observed by SOFIA for a total of 6400 s at 11.1 microns, and we report no detection of the SN, consistent with the presence of carbonaceous dust. Our upper limit is roughly an order of magnitude lower than would be expected for silicate dust grains. Either the progenitor system for this SN</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol2/pdf/CFR-2010-title49-vol2-sec178-819.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol2/pdf/CFR-2010-title49-vol2-sec178-819.pdf"><span>49 CFR 178.819 - Vibration test.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... 49 Transportation 2 2010-10-01 2010-10-01 false Vibration test. 178.819 Section 178.819... Testing of <span class="hlt">IBCs</span> § 178.819 Vibration test. (a) General. The vibration test must be conducted for the... vibration test. (b) Test method. (1) A sample <span class="hlt">IBC</span>, selected at random, must be filled and closed as for...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=Management+AND+developing+AND+country+AND+perspective&id=EJ1169885','ERIC'); return false;" href="https://eric.ed.gov/?q=Management+AND+developing+AND+country+AND+perspective&id=EJ1169885"><span>Managing International Branch Campuses: Lessons Learnt from Eight Years on a Branch Campus in Malaysia</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Hill, Christopher; Thabet, Rawy Abdelrahman</p> <p>2018-01-01</p> <p>Purpose: International branch campuses (<span class="hlt">IBCs</span>) are complex entities and while much has been written about their expansion and development, the literature is largely from an external perspective. There have been few longitudinal studies examining the development of an <span class="hlt">IBC</span> over time. The purpose of this paper is to review the development of one IBC…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27232494','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27232494"><span>[Teaching <span class="hlt">design</span> and practice of human blood <span class="hlt">type</span> traits in genetics comprehensive laboratory course].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Zhao, Jian; Hu, Dong-mei; Yu, Da-de; Dong, Ming-liang; Li, Yun; Fan, Ying-ming; Wang, Yan-wei; Zhang, Jin-feng</p> <p>2016-05-01</p> <p>Comprehensive laboratory courses, which enable students to aptly apply theoretic knowledge and master experiment skills, play an important role in the present educational reform of laboratory courses. We utilized human ABO blood <span class="hlt">type</span> as the experimental subject, and <span class="hlt">designed</span> the experiment--"Molecular Genotyping of Human ABO Blood <span class="hlt">Type</span> and Analysis of Population Genetic Equilibrium". In the experiment, DNA in mucosal cells is extracted from students' saliva, and each student's genotype is identified using a series of molecular genetics technologies, including PCR amplification of target fragments, enzymatic digestion, and electrophoretic separation. Then, taking the whole class as an analogous Mendel population, a survey of genotype frequency of ABO blood <span class="hlt">type</span> is conducted, followed with analyses of various population genetic parameters using Popgene. Through the open laboratory course, students can not only master molecular genetic experimental skills, but also improve their understanding of theoretic knowledge through independent <span class="hlt">design</span> and optimization of molecular techniques. After five years of research and practice, a stable experimental system of molecular genetics has been established to identify six genotypes of ABO blood <span class="hlt">types</span>, namely I(A)I(A), I(A)i, I(B)I(B), I(B)i, I(A)I(B) and ii. Laboratory courses of molecular and population genetics have been integrated by calculating the frequencies of the six genotypes and three multiple alleles and testing population genetic equilibrium. The goal of the open laboratory course with independent <span class="hlt">design</span> and implementation by the students has been achieved. This laboratory course has proved effective and received good reviews from the students. It could be applied as a genetics laboratory course for the biology majors directly, and its ideas and methods could be promoted and applied to other biological laboratory courses.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26862240','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26862240"><span><span class="hlt">Designing</span> Decision Support System to Detect Drug Interactions <span class="hlt">Type</span> 2 Diabetes.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Rasoolimoghadam, Mehdi; Safdari, Reza; Ghazisaeidi, Marjan; Maharanitehrani, MohammadReza; Tahmasebiyan, Shahram</p> <p>2015-12-01</p> <p><span class="hlt">Type</span> II Diabetes is the most common diseases of metabolic disorders and the treatment of oral anti-diabetic drug use takes place But The problem of using multi-drug and interactions at the same time is an issue that has always been a major challenge And diagnosis of drug interactions, particularly in Diabetic patients due to the problem with the disease is very important. The purpose of this studying is, to <span class="hlt">design</span> a clinical assistant decided to use this approach to determine the <span class="hlt">type</span> II diabetes drug interactions this makes it easy for those who are active in the field. Study is Developmental that to determine the content of the system a self-made checklist was used. Checklist Validity and reliability has been confirmed by four professors. The Research community to determine the content of the system was country endocrine that are 124 people. The sample size was calculated using Cochran that was 57 people. The Score of checklist was calculated in SPSS version 20 .finally, the checklist was approved by at least 70% points. The system by using Microsoft SQL server 2008 and visual Studio 2012 development environment was <span class="hlt">designed</span> in C#.net. In the end, In order to evaluate the software to determine the level of satisfaction, usability and ease of use, <span class="hlt">designed</span> systems sharing with all Medical Informatics students of Tehran University of Medical Sciences. For this purpose a self-made questionnaire was used. Questionnaire Validity has been confirmed by four professors and reliability was assessed by Cronbach method. The results of the survey are showing that the majority of students found out and believed the software is useful and easy to use and generally expressed their satisfaction software. The methodology provides a suitable approach for analysis and modeling of data in the medical field and the performance is good.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA625478','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA625478"><span>The Roles of the Bone Marrow Microenvironment in Controlling Tumor Dormancy</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2015-10-01</p> <p>Shiozawa, M.D., Ph.D. CONTRACTING ORGANIZATION: Wake Forest School of Medicine Ann Arbor, MI 48109 REPORT DATE: October 2015 <span class="hlt">TYPE</span> OF REPORT...PERFORMING ORGANIZATION REPORT NUMBER Wake Forest University Health Sciences Medical Center Blvd. Winston-Salem NC 27157 9. SPONSORING... Wake Forest School of Medicine as of 03/01/15. The PI obtained the necessary institutional approvals (IACUC, IRB, <span class="hlt">IBC</span>) and submitted the grant</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018ApPhL.112s3904Y','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018ApPhL.112s3904Y"><span>Poly-crystalline silicon-oxide films as carrier-selective passivating contacts for c-Si solar cells</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Yang, Guangtao; Guo, Peiqing; Procel, Paul; Weeber, Arthur; Isabella, Olindo; Zeman, Miro</p> <p>2018-05-01</p> <p>The poly-Si carrier-selective passivating contacts (CSPCs) parasitically absorb a substantial amount of light, especially in the form of free carrier absorption. To minimize these losses, we developed CSPCs based on oxygen-alloyed poly-Si (poly-SiOx) and deployed them in c-Si solar cells. Transmission electron microscopy analysis indicates the presence of nanometer-scale silicon crystals within such poly-SiOx layers. By varying the O content during material deposition, we can manipulate the crystallinity of the poly-SiOx material and its absorption coefficient. Also, depending on the O content, the bandgap of the poly-SiOx material can be widened, making it transparent for longer wavelength light. Thus, we optimized the O alloying, doping, annealing, and hydrogenation conditions. As a result, an extremely high passivation quality for both n-<span class="hlt">type</span> poly-SiOx (J0 = 3.0 fA/cm2 and iVoc = 740 mV) and p-<span class="hlt">type</span> poly-SiOx (J0 = 17.0 fA/cm2 and iVoc = 700 mV) is obtained. A fill factor of 83.5% is measured in front/back-contacted solar cells with both polarities made up of poly-SiOx. This indicates that the carrier transport through the junction between poly-SiOx and c-Si is sufficiently efficient. To demonstrate the merit of poly-SiOx layers' high transparency at long wavelengths, they are deployed at the back side of interdigitated back-contacted (<span class="hlt">IBC</span>) solar cells. A preliminary cell efficiency of 19.7% is obtained with much room for further improvement. Compared to an <span class="hlt">IBC</span> solar cell with poly-Si CSPCs, a higher internal quantum efficiency at long wavelengths is observed for the <span class="hlt">IBC</span> solar cell with poly-SiOx CSPCs, thus demonstrating the potential of poly-SiOx in enabling higher JSC.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24184819','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24184819"><span>Template-based de novo <span class="hlt">design</span> for <span class="hlt">type</span> II kinase inhibitors and its extented application to acetylcholinesterase inhibitors.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Su, Bo-Han; Huang, Yi-Syuan; Chang, Chia-Yun; Tu, Yi-Shu; Tseng, Yufeng J</p> <p>2013-10-31</p> <p>There is a compelling need to discover <span class="hlt">type</span> II inhibitors targeting the unique DFG-out inactive kinase conformation since they are likely to possess greater potency and selectivity relative to traditional <span class="hlt">type</span> I inhibitors. Using a known inhibitor, such as a currently available and approved drug or inhibitor, as a template to <span class="hlt">design</span> new drugs via computational de novo <span class="hlt">design</span> is helpful when working with known ligand-receptor interactions. This study proposes a new template-based de novo <span class="hlt">design</span> protocol to discover new inhibitors that preserve and also optimize the binding interactions of the <span class="hlt">type</span> II kinase template. First, sorafenib (Nexavar) and nilotinib (Tasigna), two <span class="hlt">type</span> II inhibitors with different ligand-receptor interactions, were selected as the template compounds. The five-step protocol can reassemble each drug from a large fragment library. Our procedure demonstrates that the selected template compounds can be successfully reassembled while the key ligand-receptor interactions are preserved. Furthermore, to demonstrate that the algorithm is able to construct more potent compounds, we considered kinase inhibitors and other protein dataset, acetylcholinesterase (AChE) inhibitors. The de novo optimization was initiated using a template compound possessing a less than optimal activity from a series of aminoisoquinoline and TAK-285 inhibiting <span class="hlt">type</span> II kinases, and E2020 derivatives inhibiting AChE respectively. Three compounds with greater potency than the template compound were discovered that were also included in the original congeneric series. This template-based lead optimization protocol with the fragment library can help to <span class="hlt">design</span> compounds with preferred binding interactions of known inhibitors automatically and further optimize the compounds in the binding pockets.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title49-vol2/pdf/CFR-2013-title49-vol2-sec173-12.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title49-vol2/pdf/CFR-2013-title49-vol2-sec173-12.pdf"><span>49 CFR 173.12 - Exceptions for shipment of waste materials.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-10-01</p> <p>... (<span class="hlt">IBC</span>) or a UN 11HH2 composite <span class="hlt">IBC</span>, fitted with a polyethylene liner at least 6 mils (0.006 inches... section or in single packagings authorized for the acid in Column (8B) of the § 172.101 Hazardous... packagings authorized for the material in Column (8B) of the § 172.101 Hazardous Materials Table of this...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title49-vol2/pdf/CFR-2014-title49-vol2-sec173-12.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title49-vol2/pdf/CFR-2014-title49-vol2-sec173-12.pdf"><span>49 CFR 173.12 - Exceptions for shipment of waste materials.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-10-01</p> <p>... (<span class="hlt">IBC</span>) or a UN 11HH2 composite <span class="hlt">IBC</span>, fitted with a polyethylene liner at least 6 mils (0.006 inches... section or in single packagings authorized for the acid in Column (8B) of the § 172.101 Hazardous... packagings authorized for the material in Column (8B) of the § 172.101 Hazardous Materials Table of this...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29239711','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29239711"><span>Interval Breast Cancer Rates and Histopathologic Tumor Characteristics after False-Positive Findings at Mammography in a Population-based Screening Program.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hofvind, Solveig; Sagstad, Silje; Sebuødegård, Sofie; Chen, Ying; Roman, Marta; Lee, Christoph I</p> <p>2018-04-01</p> <p>Purpose To compare rates and tumor characteristics of interval breast cancers (<span class="hlt">IBCs</span>) detected after a negative versus false-positive screening among women participating in the Norwegian Breast Cancer Screening Program. Materials and Methods The Cancer Registry Regulation approved this retrospective study. Information about 423 445 women aged 49-71 years who underwent 789 481 full-field digital mammographic screening examinations during 2004-2012 was extracted from the Cancer Registry of Norway. Rates and odds ratios of <span class="hlt">IBC</span> among women with a negative (the reference group) versus a false-positive screening were estimated by using logistic regression models adjusted for age at diagnosis and county of residence. Results A total of 1302 <span class="hlt">IBCs</span> were diagnosed after 789 481 screening examinations, of which 7.0% (91 of 1302) were detected among women with a false-positive screening as the most recent breast imaging examination before detection. By using negative screening as the reference, adjusted odds ratios of <span class="hlt">IBCs</span> were 3.3 (95% confidence interval [CI]: 2.6, 4.2) and 2.8 (95% CI: 1.8, 4.4) for women with a false-positive screening without and with needle biopsy, respectively. Women with a previous negative screening had a significantly lower proportion of tumors that were 10 mm or less (14.3% [150 of 1049] vs 50.0% [seven of 14], respectively; P < .01) and grade I tumors (13.2% [147 of 1114] vs 42.9% [six of 14]; P < .01), but a higher proportion of cases with lymph nodes positive for cancer (40.9% [442 of 1080] vs 13.3% [two of 15], respectively; P = .03) compared with women with a previous false-positive screening with benign biopsy. A retrospective review of the screening mammographic examinations identified 42.9% (39 of 91) of the false-positive cases to be the same lesion as the <span class="hlt">IBC</span>. Conclusion By using a negative screening as the reference, a false-positive screening examination increased the risk of an <span class="hlt">IBC</span> three-fold. The tumor characteristics of <span class="hlt">IBC</span> after a</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22391022-design-fabrication-mems-chevron-type-thermal-actuator','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22391022-design-fabrication-mems-chevron-type-thermal-actuator"><span><span class="hlt">Design</span> and fabrication of a MEMS chevron-<span class="hlt">type</span> thermal actuator</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Baracu, Angela, E-mail: angela.baracu@imt.ro; Voicu, Rodica; Müller, Raluca</p> <p></p> <p>This paper presents the <span class="hlt">design</span> and fabrication of a MEMS chevron-<span class="hlt">type</span> thermal actuator. The device was <span class="hlt">designed</span> for fabrication in the standard MEMS technology, where the topography of the upper layers depends on the patterns of structural and sacrificial layers underneath. The proposed actuator presents some advantages over usual thermal vertical chevron actuators by means of low operating voltages, high output force and linear movement without deformation of the shaft. The device simulations were done using COVENTOR software. The movement obtained by simulation was 12 μm, for a voltage of 0.2 V and the current intensity of 257 mA. Themore » <span class="hlt">design</span> optimizes the in-plane displacement by fixed anchors and beam inclination angle. Heating is provided by Joule dissipation. The material used for manufacture of chevron-based actuator was aluminum due to its thermal and mechanical properties. The release of the movable part was performed using isotropic dry etching by Reactive Ion Etching (RIE). A first inspection was achieved using Scanning Electron Microscope (SEM). In order to obtain the in-plane displacement we carried out electrical measurements. The thermal actuator can be used for a variety of optical and microassembling applications. This kind of thermal actuator could be integrated easily with other micro devices since its fabrication is compatible with the general semiconductor processes.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3753546','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3753546"><span>Identification and <span class="hlt">design</span> principles of low hole effective mass p-<span class="hlt">type</span> transparent conducting oxides</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Hautier, Geoffroy; Miglio, Anna; Ceder, Gerbrand; Rignanese, Gian-Marco; Gonze, Xavier</p> <p>2013-01-01</p> <p>The development of high-performance transparent conducting oxides is critical to many technologies from transparent electronics to solar cells. Whereas n-<span class="hlt">type</span> transparent conducting oxides are present in many devices, their p-<span class="hlt">type</span> counterparts are not largely commercialized, as they exhibit much lower carrier mobilities due to the large hole effective masses of most oxides. Here we conduct a high-throughput computational search on thousands of binary and ternary oxides and identify several highly promising compounds displaying exceptionally low hole effective masses (up to an order of magnitude lower than state-of-the-art p-<span class="hlt">type</span> transparent conducting oxides), as well as wide band gaps. In addition to the discovery of specific compounds, the chemical rationalization of our findings opens new directions, beyond current Cu-based chemistries, for the <span class="hlt">design</span> and development of future p-<span class="hlt">type</span> transparent conducting oxides. PMID:23939205</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/AD1048430','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/AD1048430"><span>Total RNA Sequencing Analysis of DCIS Progressing to Invasive Breast Cancer</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2017-09-01</p> <p>Public Release; Distribution Unlimited The views , opinions and/or findings contained in this report are those of the author(s) and should not be...STATEMENT Approved for Public Release; Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT: This project is <span class="hlt">designed</span> to complement a multi ...fact progress to invasive disease (<span class="hlt">IBC</span>), and complements our multi -institutional, NIH-funded study of genetic and epigenetic alterations of pre</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1991mont.iafcR....I','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1991mont.iafcR....I"><span><span class="hlt">Design</span> of multi-body Lambert <span class="hlt">type</span> orbits with specified departure and arrival positions</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ishii, Nobuaki; Kawaguchi, Jun'ichiro; Matsuo, Hiroki</p> <p>1991-10-01</p> <p>A new procedure for <span class="hlt">designing</span> a multi-body Lambert <span class="hlt">type</span> orbit comprising a multiple swingby process is developed, aiming at relieving a numerical difficulty inherent to a highly nonlinear swingby mechanism. The proposed algorithm, Recursive Multi-Step Linearization, first divides a whole orbit into several trajectory segments. Then, with a maximum use of piecewised transition matrices, a segmentized orbit is repeatedly upgraded until an approximated orbit initially based on a patched conics method eventually converges. In application to the four body earth-moon system with sun's gravitation, one of the double lunar swingby orbits including 12 lunar swingbys is successfully <span class="hlt">designed</span> without any velocity mismatch.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title49-vol2/pdf/CFR-2012-title49-vol2-sec173-12.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title49-vol2/pdf/CFR-2012-title49-vol2-sec173-12.pdf"><span>49 CFR 173.12 - Exceptions for shipment of waste materials.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-10-01</p> <p>... (<span class="hlt">IBC</span>) or a UN 11HH2 composite <span class="hlt">IBC</span>, fitted with a polyethylene liner at least 6 mils (0.24 inches) thick... accordance paragraph (b) of this section or in single packagings authorized for the acid in Column (8B) of... this section or in single packagings authorized for the material in Column (8B) of the § 172.101...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title49-vol2/pdf/CFR-2011-title49-vol2-sec173-12.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title49-vol2/pdf/CFR-2011-title49-vol2-sec173-12.pdf"><span>49 CFR 173.12 - Exceptions for shipment of waste materials.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-10-01</p> <p>... (<span class="hlt">IBC</span>) or a UN 11HH2 composite <span class="hlt">IBC</span>, fitted with a polyethylene liner at least 6 mils (0.24 inches) thick... accordance paragraph (b) of this section or in single packagings authorized for the acid in Column (8B) of... this section or in single packagings authorized for the material in Column (8B) of the § 172.101...</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li class="active"><span>18</span></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_18 --> <div id="page_19" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li class="active"><span>19</span></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="361"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22939327','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22939327"><span>Idiopathic bone cavities of the mandible: an update on recurrence rates and case report.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Horne, Robert P; Meara, Daniel J; Granite, Edwin L</p> <p>2014-02-01</p> <p>Idiopathic bone cavities (<span class="hlt">IBCs</span>) are usually an incidental finding, often found in long bones but also in the craniofacial skeleton. Typically solitary, <span class="hlt">IBCs</span> can present at multiple sites. Surgical exploration alone has proved effective, although recurrence does occur, particularly in cases with multiple lesions. The average time necessary to observe either recurrence or complete healing has been reported to be more than 3 years. Previously reported low recurrence rates for <span class="hlt">IBCs</span> in the craniofacial skeleton may have been artificially low because of insufficient long-term follow-up. Providers should be prepared for long-term follow-up and care of these patients. The case of the patient presented here supports the need for long-term follow-up. Copyright © 2014 Elsevier Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/7998882','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/7998882"><span>Concept <span class="hlt">designs</span> of nonrotating-<span class="hlt">type</span> centrifugal blood pump and basic study on output characteristics of the oscillating disk-<span class="hlt">type</span> centrifugal pump.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kabei, N; Tuichiya, K; Sakurai, Y</p> <p>1994-09-01</p> <p>When <span class="hlt">designing</span> a turbo-<span class="hlt">type</span> blood pump as an artificial heart, the gap between a rotating shaft and a pump housing should be perfectly sealed to prevent any leakage or contamination through a seal. In addition, blood coagulation in a blood chamber must be avoided. To overcome these problems, we proposed five different nonrotating-<span class="hlt">type</span> turbo pumps: a caudal-fin-<span class="hlt">type</span> axial-flow pump, a caudal-fin-<span class="hlt">type</span> centrifugal pump, a nutating-column-<span class="hlt">type</span> centrifugal pump, a nutating-collapsible-tube-<span class="hlt">type</span> centrifugal pump, and an oscillating-disk-<span class="hlt">type</span> centrifugal pump. We selected and developed the oscillating-disk-<span class="hlt">type</span> centrifugal pump that consists of a disk, a driving rod, a seal, an oscillation mechanism, and a pump housing. The disk is mounted on the end of the rod, which is connected to a high-speed DC motor through an oscillation mechanism. The rod and the disk do not rotate, but they oscillate in the pump housing. This movement of the disk generates forward fluid flow around the axis (i.e., the rotational fluid flow). Centrifugal force due to fluid rotation supports the pressure difference between the outlet and the inlet. The diameter of the disk is 39 mm, the maximum inner diameter of the pump housing is 40 mm, and the volume of the blood chamber for 25 degrees' oscillation is 16.9 ml. The performance of the pump was tested in a mock circulatory system.(ABSTRACT TRUNCATED AT 250 WORDS)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1214156','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1214156"><span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Hegedus, Steven S.</p> <p></p> <p>An interdigitated back contact (<span class="hlt">IBC</span>) Si wafer solar cell with deposited a-Si heterojunction (HJ) emitter and contacts is considered the ultimate single junction Si solar cell <span class="hlt">design</span>. This was confirmed in 2014 by both Panasonic and Sharp Solar producing <span class="hlt">IBC</span>-HJ cells breaking the previous record Si solar cell efficiency of 25%. But manufacturability at low cost is a concern for the complex <span class="hlt">IBC</span>-HJ device structure. In this research program, our goals were to addressed the broad industry need for a high-efficiency c-Si cell that overcomes the dominant module cost barriers by 1) developing thin Si wafers synthesized by innovative, kerflessmore » techniques; 2) integrating laser-based processing into most aspects of solar cell fabrication, ensuring high speed and low thermal budgets ; 3) developing an all back contact cell structure compatible with thin wafers using a simplified, low-temperature fabrication process; and 4) <span class="hlt">designing</span> the contact patterning to enable simplified module assembly. There were a number of significant achievements from this 3 year program. Regarding the front surface, we developed and applied new method to characterize critical interface recombination parameters including interface defect density Dit and hole and electron capture cross-section for use as input for 2D simulation of the <span class="hlt">IBC</span> cell to guide <span class="hlt">design</span> and loss analysis. We optimized the antireflection and passivation properties of the front surface texture and a-Si/a-SiN/a-SiC stack depositions to obtain a very low (< 6 mA/cm2) front surface optical losses (reflection and absorption) while maintaining excellent surface passivation (SRV<5 cm/s). We worked with kerfless wafer manufacturers to apply defect-engineering techniques to improve bulk minority-carrier lifetime of thin kerfless wafers by both reducing initial impurities during growth and developing post-growth gettering techniques. This led insights about the kinetics of nickel, chromium, and dislocations in PV-grade silicon and</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1224531','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1224531"><span>Low cost back contact heterojunction solar cells on thin c-Si wafers. integrating laser and thin film processing for improved manufacturability</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Hegedus, Steven S.</p> <p>2015-09-08</p> <p>An interdigitated back contact (<span class="hlt">IBC</span>) Si wafer solar cell with deposited a-Si heterojunction (HJ) emitter and contacts is considered the ultimate single junction Si solar cell <span class="hlt">design</span>. This was confirmed in 2014 by both Panasonic and Sharp Solar producing <span class="hlt">IBC</span>-HJ cells breaking the previous record Si solar cell efficiency of 25%. But manufacturability at low cost is a concern for the complex <span class="hlt">IBC</span>-HJ device structure. In this research program, our goals were to addressed the broad industry need for a high-efficiency c-Si cell that overcomes the dominant module cost barriers by 1) developing thin Si wafers synthesized by innovative, kerflessmore » techniques; 2) integrating laser-based processing into most aspects of solar cell fabrication, ensuring high speed and low thermal budgets ; 3) developing an all back contact cell structure compatible with thin wafers using a simplified, low-temperature fabrication process; and 4) <span class="hlt">designing</span> the contact patterning to enable simplified module assembly. There were a number of significant achievements from this 3 year program. Regarding the front surface, we developed and applied new method to characterize critical interface recombination parameters including interface defect density Dit and hole and electron capture cross-section for use as input for 2D simulation of the <span class="hlt">IBC</span> cell to guide <span class="hlt">design</span> and loss analysis. We optimized the antireflection and passivation properties of the front surface texture and a-Si/a-SiN/a-SiC stack depositions to obtain a very low (< 6 mA/cm2) front surface optical losses (reflection and absorption) while maintaining excellent surface passivation (SRV<5 cm/s). We worked with kerfless wafer manufacturers to apply defect-engineering techniques to improve bulk minority-carrier lifetime of thin kerfless wafers by both reducing initial impurities during growth and developing post-growth gettering techniques. This led insights about the kinetics of nickel, chromium, and dislocations in PV-grade silicon and</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29681526','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29681526"><span>A <span class="hlt">Designed</span> Peptide Targets Two <span class="hlt">Types</span> of Modifications of p53 with Anti-cancer Activity.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Liang, Lunxi; Wang, Huanbin; Shi, Hubing; Li, Zhaoli; Yao, Han; Bu, Zhigao; Song, Ningning; Li, Chushu; Xiang, Dabin; Zhang, Yao; Wang, Jilin; Hu, Ye; Xu, Qi; Ma, Yanlei; Cheng, Zhongyi; Wang, Yingchao; Zhao, Shuliang; Qian, Jin; Chen, Yingxuan; Fang, Jing-Yuan; Xu, Jie</p> <p>2018-06-21</p> <p>Many cancer-related proteins are controlled by composite post-translational modifications (PTMs), but prevalent strategies only target one <span class="hlt">type</span> of modification. Here we describe a <span class="hlt">designed</span> peptide that controls two <span class="hlt">types</span> of modifications of the p53 tumor suppressor, based on the discovery of a protein complex that suppresses p53 (suppresome). We found that Morn3, a cancer-testis antigen, recruits different PTM enzymes, such as sirtuin deacetylase and ubiquitin ligase, to confer composite modifications on p53. The molecular functions of Morn3 were validated through in vivo assays and chemico-biological intervention. A rationally <span class="hlt">designed</span> Morn3-targeting peptide (Morncide) successfully activated p53 and suppressed tumor growth. These findings shed light on the regulation of protein PTMs and present a strategy for targeting two modifications with one molecule. Copyright © 2018 Elsevier Ltd. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4720826','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4720826"><span><span class="hlt">Designing</span> Decision Support System to Detect Drug Interactions <span class="hlt">Type</span> 2 Diabetes</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Rasoolimoghadam, Mehdi; Safdari, Reza; Ghazisaeidi, Marjan; Maharanitehrani, MohammadReza; Tahmasebiyan, Shahram</p> <p>2015-01-01</p> <p>Background and Aim: <span class="hlt">Type</span> II Diabetes is the most common diseases of metabolic disorders and the treatment of oral anti-diabetic drug use takes place But The problem of using multi-drug and interactions at the same time is an issue that has always been a major challenge And diagnosis of drug interactions, particularly in Diabetic patients due to the problem with the disease is very important. The purpose of this studying is, to <span class="hlt">design</span> a clinical assistant decided to use this approach to determine the <span class="hlt">type</span> II diabetes drug interactions this makes it easy for those who are active in the field. Materials and Methods: Study is Developmental that to determine the content of the system a self-made checklist was used. Checklist Validity and reliability has been confirmed by four professors. The Research community to determine the content of the system was country endocrine that are 124 people. The sample size was calculated using Cochran that was 57 people. The Score of checklist was calculated in SPSS version 20 .finally, the checklist was approved by at least 70% points. The system by using Microsoft SQL server 2008 and visual Studio 2012 development environment was <span class="hlt">designed</span> in C#.net. In the end, In order to evaluate the software to determine the level of satisfaction, usability and ease of use, <span class="hlt">designed</span> systems sharing with all Medical Informatics students of Tehran University of Medical Sciences. For this purpose a self-made questionnaire was used. Questionnaire Validity has been confirmed by four professors and reliability was assessed by Cronbach method. Results: The results of the survey are showing that the majority of students found out and believed the software is useful and easy to use and generally expressed their satisfaction software. Conclusions: The methodology provides a suitable approach for analysis and modeling of data in the medical field and the performance is good. PMID:26862240</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19940031916','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19940031916"><span>Vibration reduction in helicopter rotors using an actively controlled partial span trailing edge flap located on the blade</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Millott, T. A.; Friedmann, P. P.</p> <p>1994-01-01</p> <p>This report describes an analytical study of vibration reduction in a four-bladed helicopter rotor using an actively controlled, partial span, trailing edge flap located on the blade. The vibration reduction produced by the actively controlled flap (ACF) is compared with that obtained using individual blade control (<span class="hlt">IBC</span>), in which the entire blade is oscillated in pitch. For both cases a deterministic feedback controller is implemented to reduce the 4/rev hub loads. For all cases considered, the ACF produced vibration reduction comparable with that obtained using <span class="hlt">IBC</span>, but consumed only 10-30% of the power required to implement <span class="hlt">IBC</span>. A careful parametric study is conducted to determine the influence of blade torsional stiffness, spanwise location of the control flap, and hinge moment correction on the vibration reduction characteristics of the ACF. The results clearly demonstrate the feasibility of this new approach to vibration reduction. It should be emphasized than the ACF, used together with a conventional swashplate, is completely decoupled from the primary flight control system and thus it has no influence on the airworthiness of the helicopter. This attribute is potentially a significant advantage when compared to <span class="hlt">IBC</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015MS%26E...99a2027I','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015MS%26E...99a2027I"><span>Effect of Human Movement on Galvanic Intra-Body Communication during Single Gait Cycle</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ibrahim, I. W.; Razak, A. H. A.; Ahmad, A.; Salleh, M. K. M.</p> <p>2015-11-01</p> <p>Intra-body communication (<span class="hlt">IBC</span>) is a communication system that uses human body as a signal transmission medium. From previous research, two coupling methods of <span class="hlt">IBC</span> were concluded which are capacitive coupling and galvanic coupling. This paper investigates the effect of human movement on <span class="hlt">IBC</span> using the galvanic coupling method. Because the human movement is control by the limb joint, the knee flexion angle during gait cycle was used to examine the influence of human movement on galvanic coupling <span class="hlt">IBC</span>. The gait cycle is a cycle of people walking that start from one foot touch the ground till that foot touch the ground again. Frequency range from 300 kHz to 200MHz was swept in order to investigate the signal transmission loss and the result was focused on operating frequency 70MHz to 90MHz. Results show that the transmission loss varies when the knee flexion angle increased. The highest loss of signal at frequency range between 70MHz to 90 MHz was 69dB when the knee flexion angle is 50° and the minimum loss was 51dB during the flexion angle is 5°.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29866126','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29866126"><span>Electrical exposure analysis of galvanic-coupled intra-body communication based on the empirical arm models.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Gao, Yue-Ming; Zhang, Heng-Fei; Lin, Shi; Jiang, Rui-Xin; Chen, Zhi-Ying; Lučev Vasić, Željka; Vai, Mang-I; Du, Min; Cifrek, Mario; Pun, Sio-Hang</p> <p>2018-06-05</p> <p>Intra-body communication (<span class="hlt">IBC</span>) is one of the highlights in studies of body area networks. The existing <span class="hlt">IBC</span> studies mainly focus on human channel characteristics of the physical layer, transceiver <span class="hlt">design</span> for the application, and the protocol <span class="hlt">design</span> for the networks. However, there are few safety analysis studies of the <span class="hlt">IBC</span> electrical signals, especially for the galvanic-coupled <span class="hlt">type</span>. Besides, the human channel model used in most of the studies is just a multi-layer homocentric cylinder model, which cannot accurately approximate the real human tissue layer. In this paper, the empirical arm models were established based on the geometrical information of six subjects. The thickness of each tissue layer and the anisotropy of muscle were also taken into account. Considering the International Commission on Non-Ionizing Radiation Protection (ICNIRP) guidelines, the restrictions taken as the evaluation criteria were the electric field intensity lower than 1.35 × 10 4 f V/m and the specific absorption rate (SAR) lower than 4 W/kg. The physiological electrode LT-1 was adopted in experiments whose size was 4 × 4 cm and the distance between each center of adjoining electrodes was 6 cm. The electric field intensity and localized SAR were all computed by the finite element method (FEM). The electric field intensity was set as average value of all tissues, while SAR was averaged over 10 g contiguous tissue. The computed data were compared with the 2010 ICNIRP guidelines restrictions in order to address the exposure restrictions of galvanic-coupled <span class="hlt">IBC</span> electrical signals injected into the body with different amplitudes and frequencies. The input alternating signal was 1 mA current or 1 V voltage with the frequency range from 10 kHz to 1 MHz. When the subject was stimulated by a 1 mA alternating current, the average electric field intensity of all subjects exceeded restrictions when the frequency was lower than 20 kHz. The maximum difference among six subjects</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016SPIE10150E..05S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016SPIE10150E..05S"><span>Optimization <span class="hlt">design</span> of periscope <span class="hlt">type</span> 3X zoom lens <span class="hlt">design</span> for a five megapixel cellphone camera</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Sun, Wen-Shing; Tien, Chuen-Lin; Pan, Jui-Wen; Chao, Yu-Hao; Chu, Pu-Yi</p> <p>2016-11-01</p> <p>This paper presents a periscope <span class="hlt">type</span> 3X zoom lenses <span class="hlt">design</span> for a five megapixel cellphone camera. The configuration of optical system uses the right angle prism in front of the zoom lenses to change the optical path rotated by a 90° angle resulting in the zoom lenses length of 6 mm. The zoom lenses can be embedded in mobile phone with a thickness of 6 mm. The zoom lenses have three groups with six elements. The half field of view is varied from 30° to 10.89°, the effective focal length is adjusted from 3.142 mm to 9.426 mm, and the F-number is changed from 2.8 to 5.13.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1433111','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1433111"><span>ClusterCAD: a computational platform for <span class="hlt">type</span> I modular polyketide synthase <span class="hlt">design</span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Eng, Clara H.; Backman, Tyler W H; Bailey, Constance B.</p> <p></p> <p>Here, we present ClusterCAD, a web-based toolkit <span class="hlt">designed</span> to leverage the collinear structure and deterministic logic of <span class="hlt">type</span> I modular polyketide synthases (PKSs) for synthetic biology applications. The unique organization of these megasynthases, combined with the diversity of their catalytic domain building blocks, has fueled an interest in harnessing the biosynthetic potential of PKSs for the microbial production of both novel natural product analogs and industrially relevant small molecules. However, a limited theoretical understanding of the determinants of PKS fold and function poses a substantial barrier to the <span class="hlt">design</span> of active variants, and identifying strategies to reliably construct functional PKSmore » chimeras remains an active area of research. In this work, we formalize a paradigm for the <span class="hlt">design</span> of PKS chimeras and introduce ClusterCAD as a computational platform to streamline and simplify the process of <span class="hlt">designing</span> experiments to test strategies for engineering PKS variants. ClusterCAD provides chemical structures with stereochemistry for the intermediates generated by each PKS module, as well as sequence- and structure-based search tools that allow users to identify modules based either on amino acid sequence or on the chemical structure of the cognate polyketide intermediate. ClusterCAD can be accessed at https://clustercad.jbei.org and at http://clustercad.igb.uci.edu.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1433111-clustercad-computational-platform-type-modular-polyketide-synthase-design','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1433111-clustercad-computational-platform-type-modular-polyketide-synthase-design"><span>ClusterCAD: a computational platform for <span class="hlt">type</span> I modular polyketide synthase <span class="hlt">design</span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Eng, Clara H.; Backman, Tyler W H; Bailey, Constance B.; ...</p> <p>2017-10-11</p> <p>Here, we present ClusterCAD, a web-based toolkit <span class="hlt">designed</span> to leverage the collinear structure and deterministic logic of <span class="hlt">type</span> I modular polyketide synthases (PKSs) for synthetic biology applications. The unique organization of these megasynthases, combined with the diversity of their catalytic domain building blocks, has fueled an interest in harnessing the biosynthetic potential of PKSs for the microbial production of both novel natural product analogs and industrially relevant small molecules. However, a limited theoretical understanding of the determinants of PKS fold and function poses a substantial barrier to the <span class="hlt">design</span> of active variants, and identifying strategies to reliably construct functional PKSmore » chimeras remains an active area of research. In this work, we formalize a paradigm for the <span class="hlt">design</span> of PKS chimeras and introduce ClusterCAD as a computational platform to streamline and simplify the process of <span class="hlt">designing</span> experiments to test strategies for engineering PKS variants. ClusterCAD provides chemical structures with stereochemistry for the intermediates generated by each PKS module, as well as sequence- and structure-based search tools that allow users to identify modules based either on amino acid sequence or on the chemical structure of the cognate polyketide intermediate. ClusterCAD can be accessed at https://clustercad.jbei.org and at http://clustercad.igb.uci.edu.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1997APS..MAR.F2110G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1997APS..MAR.F2110G"><span>Landau-<span class="hlt">type</span> expansion for the energy landscape of the <span class="hlt">designed</span> heteropolymer</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Grosberg, Alexander; Pande, Vijay; Tanaka, Toyoichi</p> <p>1997-03-01</p> <p>The concept of evolutional optimization of heteropolymer sequences is used to construct the phenomenological theory describing folding/unfoolding kinetics of the polymers with <span class="hlt">designed</span> sequences. The relevant energy landscape is described in terms of Landau expansion over the powers of the overlap parameter of the current and the native conformations. It is shown that only linear term is sequence (mutation) dependent, the rest being determined by the underlying conformational geometry. The theory os free of the assumptions of the uncorrelated energy landscape <span class="hlt">type</span>. We demonstrate the power of the theory by comparing data to the simulations and experiments.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012SPIE.8292E..06K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012SPIE.8292E..06K"><span>Color universal <span class="hlt">design</span>: analysis of color category dependency on color vision <span class="hlt">type</span> (3)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kojima, Natsuki; Ichihara, Yasuyo G.; Ikeda, Tomohiro; Kamachi, Miyuki G.; Ito, Kei</p> <p>2012-01-01</p> <p>We report on the results of a study investigating the color perception characteristics of people with red-green color confusion. We believe that this is an important step towards achieving Color Universal <span class="hlt">Design</span>. In Japan, approximately 5% of men and 0.2% of women have red-green confusion. The percentage for men is higher in Europe and the United States; up to 8% in some countries. Red-green confusion involves a perception of colors different from normal color vision. Colors are used as a means of disseminating clear information to people; however, it may be difficult to convey the correct information to people who have red-green confusion. Consequently, colors should be chosen that minimize accidents and that promote more effective communication. In a previous survey, we investigated color categories common to each color vision <span class="hlt">type</span>, trichromat (C-<span class="hlt">type</span> color vision), protan (P-<span class="hlt">type</span> color vision) and deuteran (D-<span class="hlt">type</span> color vision). In the present study, first, we conducted experiments in order to verify a previous survey of C-<span class="hlt">type</span> color vision and P-<span class="hlt">type</span> color vision. Next, we investigated color difference levels within "CIE 1976 L*a*b*" (the CIELAB uniform color space), where neither C-<span class="hlt">type</span> nor P-<span class="hlt">type</span> color vision causes accidents under certain conditions (rain maps/contour line levels and graph color legend levels). As a result, we propose a common chromaticity of colors that the two color vision <span class="hlt">types</span> are able to categorize by means of color names common to C-<span class="hlt">type</span> color vision. We also offer a proposal to explain perception characteristics of color differences with normal color vision and red-green confusion using the CIELAB uniform color space. This report is a follow-up to SPIE-IS & T / Vol. 7528 7528051-8 and SPIE-IS & T /vol. 7866 78660J-1-8.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1997PASA...14..208W','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1997PASA...14..208W"><span>Initial statistics from the Perth Automated Supernova Search</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Williams, A. J.</p> <p>1997-08-01</p> <p>The Perth Automated Supernova Search uses the 61-cm PLAT (Perth Lowell Automated Telescope) at Perth Observatory, Western Australia. Since 1993 January 1, five confirmed supernovae have been found by the search. The analysis of the first three years of data is discussed, and preliminary results presented. We find a <span class="hlt">Type</span> <span class="hlt">Ib/c</span> rate of 0.43 +/- 0.43 SNu, and a <span class="hlt">Type</span> IIP rate of 0.86 +/- 0.49 SNu, where SNu are 'supernova units'. These values are for a Hubble constant of 75 km per sec per Mpc.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/12185381','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/12185381"><span>Measurement of the ultrasonic properties of human coronary arteries in vitro with a 50-MHz acoustic microscope.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Machado, J C; Foster, F S; Gotlieb, A I</p> <p>2002-08-01</p> <p>Ultrasonic attenuation coefficient, wave propagation speed and integrated backscatter coefficient (<span class="hlt">IBC</span>) of human coronary arteries were measured in vitro over the -6 dB frequency bandwidth (36 to 67 MHz) of a focused ultrasound transducer (50 MHz, focal distance 5.7 mm, f/number 1.7). Corrections were made for diffraction effects. Normal and diseased coronary artery sub-samples (N = 38) were obtained from 10 individuals at autopsy. The measured mean +/- SD of the wave speed (average over the entire vessel wall thickness) was 1581.04 +/- 53.88 m/s. At 50 MHz, the average attenuation coefficient was 4.99 +/- 1.33 dB/mm with a frequency dependence term of 1.55 +/- 0.18 determined over the 36- to 67-MHz frequency range. The <span class="hlt">IBC</span> values were: 17.42 +/- 13.02 (sr.m)-1 for thickened intima, 11.35 +/- 6.54 (sr.m)-1 for fibrotic intima, 39.93 +/- 50.95 (sr.m)-1 for plaque, 4.26 +/- 2.34 (sr.m)-1 for foam cells, 5.12 +/- 5.85 (sr.m)-1 for media and 21.26 +/- 31.77 (sr.m)-1 for adventitia layers. The <span class="hlt">IBC</span> results indicate the possibility for ultrasound characterization of human coronary artery wall tissue layer, including the situations of diseased arteries with the presence of thickened intima, fibrotic intima and plaque. The mean <span class="hlt">IBC</span> normalized with respect to the mean <span class="hlt">IBC</span> of the media layer seems promising for use as a parameter to differentiate a plaque or a thickened intima from a fibrotic intima.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1440314','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1440314"><span>Wave Energy Prize -- Carderock Test <span class="hlt">Design</span> and Rigging to Accommodate Diversity of Device <span class="hlt">Types</span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Driscoll, Frederick R</p> <p></p> <p>Wave Energy Prize Carderock Test <span class="hlt">Design</span> and Rigging to Accommodate Diversity of Device <span class="hlt">Types</span> presentation from the Water Power Technologies Office Peer Review, FY14-FY16. The challenge was to determine testing conditions, develop processing algorithms, and execute tests for equitable and consistent evaluation of different wave energy converter (WEC) technologies.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/ADA432933','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/ADA432933"><span>The Establishment of an Inflammatory Breast Cancer Registry and Biospecimen Repository</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2004-08-01</p> <p>will be presented at the San Antonio Breast Cancer Conference in December, 2004. The clinical data include the observation that approximately one third...of <span class="hlt">IBC</span> patients are initially diagnosed as having mastitis and are treated with up to five months of antibiotics before the diagnosis of cancer is...developed a national registry of patients with <span class="hlt">IBC</span> which contains standardized clinical , epidemiological and pathological information. Our registry includes</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017JPhCS.823a2025S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017JPhCS.823a2025S"><span><span class="hlt">Design</span> of a Prototype Positive Ion Source with Slit Aperture <span class="hlt">Type</span> Extraction System</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Sharma, Sanjeev K.; Vattilli, Prahlad; Choksi, Bhargav; Punyapu, Bharathi; Sidibomma, Rambabu; Bonagiri, Sridhar; Aggrawal, Deepak; Baruah, Ujjwal K.</p> <p>2017-04-01</p> <p>The neutral beam injector group at IPR aims at developing an experimental positive ion source capable of delivering H+ ion beam having energy of 30 - 40 keV and carrying an ion beam current of 5 A. The slit aperture based extraction system is chosen for extracting and accelerating the ions so as to achieve low divergence of the ion beam (< 0.5°). For producing H+ ions a magnetic multi-pole bucket <span class="hlt">type</span> plasma chamber is selected. We calculated the magnetic field due to cusp magnets and trajectories (orbits) of the primary electrons to investigate the two magnetic configurations i.e. line cusp and checker board. Numerical simulation is also carried out by using OPERA-3D to study the characteristic performance of the slit aperture <span class="hlt">type</span> extraction-acceleration system. We report here the results of the studies carried out on various aspects of the <span class="hlt">design</span> of the slit aperture <span class="hlt">type</span> positive ion source.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/publication/?seqNo115=250015','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/publication/?seqNo115=250015"><span>HEALTHY study rationale, <span class="hlt">design</span> and methods: Moderating risk of <span class="hlt">type</span> 2 diabetes in multi-ethnic middle school students</span></a></p> <p><a target="_blank" href="https://www.ars.usda.gov/research/publications/find-a-publication/">USDA-ARS?s Scientific Manuscript database</a></p> <p></p> <p></p> <p>The HEALTHY primary prevention trial was <span class="hlt">designed</span> and implemented in response to the growing numbers of children and adolescents being diagnosed with <span class="hlt">type</span> 2 diabetes. The objective was to moderate risk factors for <span class="hlt">type</span> 2 diabetes. Modifiable risk factors measured were indicators of adiposity and gly...</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li class="active"><span>19</span></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_19 --> <div id="page_20" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li class="active"><span>20</span></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="381"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5450250','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5450250"><span>Epitope <span class="hlt">design</span> of L1 protein for vaccine production against Human Papilloma Virus <span class="hlt">types</span> 16 and 18</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Baidya, Sunanda; Das, Rasel; Kabir, Md. Golam; Arifuzzaman, Md.</p> <p>2017-01-01</p> <p>Cervical cancer accounts for about two-thirds of all cancer cases linked etiologically to Human Papilloma Virus (HPV). 15 oncogenic HPV <span class="hlt">types</span> can cause cervical cancer, of which HPV16 and HPV18 combinedly account for about 70% of it. So, effective epitope <span class="hlt">design</span> for the clinically relevant HPV <span class="hlt">types</span> 16 and 18 would be of major medical benefit. Here, a comprehensive analysis is carried out to predict the epitopes against HPV <span class="hlt">types</span> 16 and 18 through “reverse vaccinology” approach. We attempted to identify the evolutionarily conserved regions of major capsid protein (L1) as well as minor capsid protein (L2) of HPV and <span class="hlt">designed</span> epitopes within these regions. In this study, we analyzed about 49 and 27 sequences of HPV L2 and L1 proteins respectively. Since we found that the intertype variability of L2 is higher than for L1 proteins, our analysis was emphasized on epitopes of L1 of HPV <span class="hlt">types</span> 16 and 18. We had selected HLA-A*0201, DRB1*1501, DQB1*0602, DRB1*0401 and DQB1*0301 alleles for the prediction of T cell epitopes of L1 of HPV 16 and 18. Finally, we reported that predicted epitope sequences EEYDLQFIFQLCKITLTA, and RHGEEYDLQFIFQLCKITLTA of L1 protein of HPV 16, and LPDPNKF, PETQRLVWAC, PVPGQYDA, YNPETQRLVWAC, DTGYGAMD, PVPGQYDATK, KQDIPKVSAYQYRVFRV, RDNVSVDYKQTQLCI and YSRHVEEYDLQFIF of L1 protein of HPV 18 could be therapeutic tools for vaccine <span class="hlt">design</span> against HPV. PMID:28584449</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28584449','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28584449"><span>Epitope <span class="hlt">design</span> of L1 protein for vaccine production against Human Papilloma Virus <span class="hlt">types</span> 16 and 18.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Baidya, Sunanda; Das, Rasel; Kabir, Md Golam; Arifuzzaman, Md</p> <p>2017-01-01</p> <p>Cervical cancer accounts for about two-thirds of all cancer cases linked etiologically to Human Papilloma Virus (HPV). 15 oncogenic HPV <span class="hlt">types</span> can cause cervical cancer, of which HPV16 and HPV18 combinedly account for about 70% of it. So, effective epitope <span class="hlt">design</span> for the clinically relevant HPV <span class="hlt">types</span> 16 and 18 would be of major medical benefit. Here, a comprehensive analysis is carried out to predict the epitopes against HPV <span class="hlt">types</span> 16 and 18 through "reverse vaccinology" approach. We attempted to identify the evolutionarily conserved regions of major capsid protein (L1) as well as minor capsid protein (L2) of HPV and <span class="hlt">designed</span> epitopes within these regions. In this study, we analyzed about 49 and 27 sequences of HPV L2 and L1 proteins respectively. Since we found that the intertype variability of L2 is higher than for L1 proteins, our analysis was emphasized on epitopes of L1 of HPV <span class="hlt">types</span> 16 and 18. We had selected HLA-A*0201, DRB1*1501, DQB1*0602, DRB1*0401 and DQB1*0301 alleles for the prediction of T cell epitopes of L1 of HPV 16 and 18. Finally, we reported that predicted epitope sequences EEYDLQFIFQLCKITLTA, and RHGEEYDLQFIFQLCKITLTA of L1 protein of HPV 16, and LPDPNKF, PETQRLVWAC, PVPGQYDA, YNPETQRLVWAC, DTGYGAMD, PVPGQYDATK, KQDIPKVSAYQYRVFRV, RDNVSVDYKQTQLCI and YSRHVEEYDLQFIF of L1 protein of HPV 18 could be therapeutic tools for vaccine <span class="hlt">design</span> against HPV.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2007AIPC..924..373P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2007AIPC..924..373P"><span><span class="hlt">Type</span> Ia Supernova Rates Near and Far</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Panagia, Nino; Della Valle, Massimo; Mannucci, Filippo</p> <p>2007-08-01</p> <p>Recently, three important observational results were established: (a) The evolution of the SNIa rate with redshift is now measured up to z~1.6 and the results at the highest redshifts, derived by the GOODS collaboration show that the SN rate rises up to z~0.8, when the Universe was 6.5 Gyr old, and decreases afterward. (b) The rate of supernova explosions of the different <span class="hlt">types</span> as a function of the galaxy (B-K) and the galaxy mass have been determined. It is found that the rates of all SN <span class="hlt">types</span>, including Ia, <span class="hlt">Ib/c</span> and II, show a marked increase with the star formation activity. (c) An analysis of SNIa events in early-<span class="hlt">type</span> galaxies has provided conclusive evidence that the rate of SNIa in radio-loud galaxies is much higher than the rate measured in radio-quiet galaxies. This result suggests that repeated episodes of interaction and/or mergers of early-<span class="hlt">type</span> galaxies with dwarf companions are responsible for supplying an adequate number of SNIa progenitors to the stellar population of elliptical galaxies. On this basis we have discussed the distribution of the delay time (DTD) between the formation of a SNIa progenitor star and its explosion as a SNIa. Our analysis finds: i) models with long delay times, say 3-4 Gyr, cannot reproduce the dependence of the SNIa rate on the colors and on the radio-luminosity of the parent galaxies; ii) the dependence of the SNIa rate on the parent galaxy colors requires models with a wide DTD, spanning the interval 100 Myr to 10 Gyr; iii) the dependence on the parent galaxy radio-luminosity requires substantial production of SNIa at epochs earlier than 100 Myr after the birth of a given stellar generation; iv) the comparison between observed SN rates and a grid of theoretical ``single-population'' DTDs shows that only a few of them are marginally consistent with all observations; v) the present data are best matched by a bimodal DTD, in which about 50% of <span class="hlt">type</span> Ia SNe (``prompt'' SNIa) explode soon after their stellar birth, in a time of</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22306417','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22306417"><span>Virtual screening filters for the <span class="hlt">design</span> of <span class="hlt">type</span> II p38 MAP kinase inhibitors: a fragment based library generation approach.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Badrinarayan, Preethi; Sastry, G Narahari</p> <p>2012-04-01</p> <p>In this work, we introduce the development and application of a three-step scoring and filtering procedure for the <span class="hlt">design</span> of <span class="hlt">type</span> II p38 MAP kinase leads using allosteric fragments extracted from virtual screening hits. The <span class="hlt">design</span> of the virtual screening filters is based on a thorough evaluation of docking methods, DFG-loop conformation, binding interactions and chemotype specificity of the 138 p38 MAP kinase inhibitors from Protein Data Bank bound to DFG-in and DFG-out conformations using Glide, GOLD and CDOCKER. A 40 ns molecular dynamics simulation with the apo, <span class="hlt">type</span> I with DFG-in and <span class="hlt">type</span> II with DFG-out forms was carried out to delineate the effects of structural variations on inhibitor binding. The <span class="hlt">designed</span> docking-score and sub-structure filters were first tested on a dataset of 249 potent p38 MAP kinase inhibitors from seven diverse series and 18,842 kinase inhibitors from PDB, to gauge their capacity to discriminate between kinase and non-kinase inhibitors and likewise to selectively filter-in target-specific inhibitors. The <span class="hlt">designed</span> filters were then applied in the virtual screening of a database of ten million (10⁷) compounds resulting in the identification of 100 hits. Based on their binding modes, 98 allosteric fragments were extracted from the hits and a fragment library was generated. New <span class="hlt">type</span> II p38 MAP kinase leads were <span class="hlt">designed</span> by tailoring the existing <span class="hlt">type</span> I ATP site binders with allosteric fragments using a common urea linker. Target specific virtual screening filters can thus be easily developed for other kinases based on this strategy to retrieve target selective compounds. Copyright © 2012 Elsevier Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016cosp...41E.824H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016cosp...41E.824H"><span>Double-wedged Wollaston-<span class="hlt">type</span> polarimeter <span class="hlt">design</span> and integration to RTT150-TFOSC</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Helhel, Selcuk; Kirbiyik, Halil; Bayar, Cevdet; Khamitov, Irek; Kahya, Gizem; Okuyan, Oguzhan</p> <p>2016-07-01</p> <p>Photometric and spectroscopic observation capabilities of 1.5-m Russian- Turkish Telescope RTT150 has been broadened with the integration of presented polarimeter. The well-known double-wedged Wollaston-<span class="hlt">type</span> dual-beam technique was preferred and applied to <span class="hlt">design</span> and produce it. The <span class="hlt">designed</span> polarimeter was integrated into the telescope detector TFOSC, and called TFOSC-WP. Its capabil- ities and limitations were attempted to be determined by a number of observation sets. Non-polarized and strongly polarized stars were observed to determine its limi- tations as well as its linearity. An instrumental intrinsic polarization was determined for the 1×5 arcmin field of view in equatorial coordinate system, the systematic error of polarization degree as 0.2% %, and position angle as 1.9°. These limitations and capabilities are denoted as good enough to satisfy telescopes' present and future astrophysical space missions related to GAIA and SRG projects.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19820003195','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19820003195"><span>Lightweight diesel engine <span class="hlt">designs</span> for commuter <span class="hlt">type</span> aircraft</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Brouwers, A. P.</p> <p>1981-01-01</p> <p>Conceptual <span class="hlt">designs</span> and performance of advanced technology lightweight diesel engines, suitable for commuter <span class="hlt">type</span> aircraft power plants are defined. Two engines are discussed, a 1491 kW (2000 SHP) eight-cylinder engine and a 895 kW (1200 SHP) six-cylinder engine. High performance and related advanced technologies are proposed such as insulated cylinders, very high injection pressures and high compressor and turbine efficiencies. The description of each engine includes concept drawings, a performance analysis, and weight data. Fuel flow data are given for full and partial power up to 7620m altitude. The performance data are also extrapolated over a power range from 671 kW(900SHP) to 1864 kW (2500 SHP). The specific fuel consumption of the 1491 kW (2000 SHP) engine is 182 g/hWh (.299 lb/HPh) at cruise altitude, its weight 620 kg (1365 lb.) and specific weight .415 kg/kW (.683 lb/HP). The specific fuel consumption of the 895 kW (1200 SHP) engine is 187 g/hWh (.308 lb/HPh) at cruise altitude, its weight 465 kg (1025 lb.) and specific weight .520 kg/kW (.854 lb/HP).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018AcSpA.196..385Y','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018AcSpA.196..385Y"><span><span class="hlt">Design</span> of butterfly <span class="hlt">type</span> organic dye sensitizers with double electron donors: The first principle study</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Yang, Zhenqing; Shao, Di; Li, Juan; Tang, Lian; Shao, Changjin</p> <p>2018-05-01</p> <p>In this work, we <span class="hlt">designed</span> a series of butterfly <span class="hlt">type</span> organic dyes, named ME07-ME13 by introducing such as triphenylamine, phenothiazine, coumarin groups etc. as electron donors and further investigated their absorption spectra using density functional theory (DFT) and time-dependent DFT (TDDFT). All <span class="hlt">designed</span> dyes cover the entire visible absorption spectrum from 300 to 800 nm. It's fascinating that ME13 molecule has two absorption peak and the molar coefficient of two absorption peaks are above 4.645 × 104 M-1·cm-1. The light absorption area of ME13 exhibits an increment of 16.5-19.1% compared to ME07-ME12. Furthermore, we performed a detailed analysis on their geometrical and electronic properties, including molecular structures, energy levels, light harvesting efficiency (LHE), driving force (ΔGinject), regeneration (ΔGregen),electron dipole moments (μnormal), intermolecular electron transfer and dye/(TiO2)38 system electron transitions. The results of calculation reveal that double coumarin donors in ME13 are promising functional groups for butterfly <span class="hlt">type</span> organic dye sensitizers. It is expected that the <span class="hlt">design</span> of double donors can provide a new strategy and guidance for the investigation in high efficiency dye-sensitized devices.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29525576','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29525576"><span>Use of the LUS in sequence allele <span class="hlt">designations</span> to facilitate probabilistic genotyping of NGS-based STR <span class="hlt">typing</span> results.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Just, Rebecca S; Irwin, Jodi A</p> <p>2018-05-01</p> <p>Some of the expected advantages of next generation sequencing (NGS) for short tandem repeat (STR) <span class="hlt">typing</span> include enhanced mixture detection and genotype resolution via sequence variation among non-homologous alleles of the same length. However, at the same time that NGS methods for forensic DNA <span class="hlt">typing</span> have advanced in recent years, many caseworking laboratories have implemented or are transitioning to probabilistic genotyping to assist the interpretation of complex autosomal STR <span class="hlt">typing</span> results. Current probabilistic software programs are <span class="hlt">designed</span> for length-based data, and were not intended to accommodate sequence strings as the product input. Yet to leverage the benefits of NGS for enhanced genotyping and mixture deconvolution, the sequence variation among same-length products must be utilized in some form. Here, we propose use of the longest uninterrupted stretch (LUS) in allele <span class="hlt">designations</span> as a simple method to represent sequence variation within the STR repeat regions and facilitate - in the nearterm - probabilistic interpretation of NGS-based <span class="hlt">typing</span> results. An examination of published population data indicated that a reference LUS region is straightforward to define for most autosomal STR loci, and that using repeat unit plus LUS length as the allele <span class="hlt">designator</span> can represent greater than 80% of the alleles detected by sequencing. A proof of concept study performed using a freely available probabilistic software demonstrated that the LUS length can be used in allele <span class="hlt">designations</span> when a program does not require alleles to be integers, and that utilizing sequence information improves interpretation of both single-source and mixed contributor STR <span class="hlt">typing</span> results as compared to using repeat unit information alone. The LUS concept for allele <span class="hlt">designation</span> maintains the repeat-based allele nomenclature that will permit backward compatibility to extant STR databases, and the LUS lengths themselves will be concordant regardless of the NGS assay or analysis tools</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2822093','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2822093"><span><span class="hlt">Design</span> of a family-based lifestyle intervention for youth with <span class="hlt">type</span> 2 diabetes: the TODAY study</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2009-01-01</p> <p><span class="hlt">Type</span> 2 diabetes is associated with obesity and is increasing at an alarming rate in youth. Although weight loss through lifestyle change is one of the primary treatment recommendations for adults with <span class="hlt">type</span> 2 diabetes, the efficacy of this approach has not been tested with youth. This paper provides a summary of the reviews and meta-analyses of pediatric weight-loss interventions that informed the <span class="hlt">design</span> and implementation of an intensive, family-based lifestyle weight management program for adolescents with <span class="hlt">type</span> 2 diabetes and their families developed for the Treatment Options for <span class="hlt">type</span> 2 Diabetes in Adolescents and Youth (TODAY) study. A total of 1092 youth have been screened, and 704 families have been randomized for inclusion in this 15-center clinical trial sponsored by the National Institutes of Health. The TODAY study is <span class="hlt">designed</span> to test three approaches (metformin, metformin plus rosiglitazone and metformin plus an intensive lifestyle intervention) to the treatment of a diverse cohort of youth, 10–17 years of age, within 2 years of their diagnosis. The principal goal of the TODAY Lifestyle Program (TLP) is to decrease baseline weight of youth by 7–10% (or the equivalent for children who are growing in height) through changes in eating and physical activity habits, and to sustain these changes through ongoing treatment contact. The TLP is implemented by interventionists called Personal Activity and Nutrition Leaders (PALs) and delivered to youth with <span class="hlt">type</span> 2 diabetes, and at least one family support person. The TLP provides a model for taking a comprehensive, continuous care approach to the treatment of severe overweight in youth with comorbid medical conditions such as <span class="hlt">type</span> 2 diabetes. PMID:19823189</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19960003591&hterms=Friedrichshafen&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3DFriedrichshafen','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19960003591&hterms=Friedrichshafen&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3DFriedrichshafen"><span>Effect of individual blade control on noise radiation</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Swanson, S. M.; Jacklin, Stephen A.; Niesl, G.; Blaas, Achim; Kube, R.</p> <p>1995-01-01</p> <p>In a joint research program of NASA Ames Research Center, ZF Luftfahrttechnik, the German Aerospace Research Establishment (DLR), and EUROCOPTER Deutschland, a wind tunnel test was performed to evaluate the effects of Individual Blade Control (<span class="hlt">IBC</span>) on rotor noise. This test was conducted in the 40x80 ft wind tunnel at NASA Ames Research Center, utilizing a full scale MBB-BO 105 four-bladed rotor system. Three microphones were installed for determination of the radiated noise, two of them on a moveable traverse below the advancing blade side and one in a fixed location below the retreating side. Acoustic results are presented for flight conditions with Blade-Vortex-Interaction (BVI) noise radiation. High noise level reductions were measured for single harmonic control inputs. In addition to the single harmonic inputs, multi-harmonic inputs were evaluated by superimposing 2/rev to 6/rev harmonics. For the first time the efficiency of sharp wavelets (60 deg and 90 deg width) on acoustic noise were measured. In order to achieve an adequate wavelet shape at the blade tip, corrections were made to account for the blade torsional behavior. In parallel with the acoustic measurements, vibratory loads were measured during the BVI flight condition to correlate the effects of <span class="hlt">IBC</span> on noise and vibrations. It is shown how noise levels and vibrations are affected by specific <span class="hlt">IBC</span> control inputs. In addition, correlations are made between noise levels and acoustic time histories with <span class="hlt">IBC</span> phase and amplitude variations. For one <span class="hlt">IBC</span> input mode with high noise reducing efficiency, a sweep of the moveable microphone traverse below the advancing side shows the effect on BVI noise directivity.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22645232-prostatic-artery-embolization-alternative-indwelling-bladder-catheterization-manage-benign-prostatic-hyperplasia-poor-surgical-candidates','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22645232-prostatic-artery-embolization-alternative-indwelling-bladder-catheterization-manage-benign-prostatic-hyperplasia-poor-surgical-candidates"><span>Prostatic Artery Embolization as an Alternative to Indwelling Bladder Catheterization to Manage Benign Prostatic Hyperplasia in Poor Surgical Candidates</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Rampoldi, Antonio; Barbosa, Fabiane, E-mail: fabiane001@hotmail.com; Secco, Silvia</p> <p></p> <p>PurposeTo prospectively assess discontinuation of indwelling bladder catheterization (<span class="hlt">IBC</span>) and relief of lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) following prostate artery embolization (PAE) in poor surgical candidates.MethodsPatients ineligible for surgical intervention were offered PAE after at least 1 month of <span class="hlt">IBC</span> for management of urinary retention secondary to BPH; exclusion criteria for PAE included eligibility for surgery, active bladder cancer or known prostate cancer. Embolization technical and clinical success were defined as bilateral prostate embolization and removal of <span class="hlt">IBC</span>, respectively. Patients were followed for at least 6 months and evaluated for International Prostate Symptom Score, quality ofmore » life, prostate size and uroflowmetric parameters.ResultsA total of 43 patients were enrolled; bilateral embolization was performed in 33 (76.7%), unilateral embolization was performed in 8 (18.6%), and two patients could not be embolized due to tortuous and atherosclerotic pelvic vasculature (4.7%). Among the patients who were embolized, mean prostate size decreased from 75.6 ± 33.2 to 63.0 ± 23.2 g (sign rank p = 0.0001, mean reduction of 19.6 ± 17.3%), and <span class="hlt">IBC</span> removal was achieved in 33 patients (80.5%). Clavien II complications were reported in nine patients (21.9%) and included urinary tract infection (three patients, 7.3%) and recurrent acute urinary retention (six patients, 14.6%). Nine patients (22.0%) experienced post-embolization syndrome.ConclusionsPAE is a safe and feasible for the relief of LUTS and <span class="hlt">IBC</span> in highly comorbid patients without surgical treatment options.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21974884','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21974884"><span>Logistics system <span class="hlt">design</span> for biomass-to-bioenergy industry with multiple <span class="hlt">types</span> of feedstocks.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Zhu, Xiaoyan; Yao, Qingzhu</p> <p>2011-12-01</p> <p>It is technologically possible for a biorefinery to use a variety of biomass as feedstock including native perennial grasses (e.g., switchgrass) and agricultural residues (e.g., corn stalk and wheat straw). Incorporating the distinct characteristics of various <span class="hlt">types</span> of biomass feedstocks and taking into account their interaction in supplying the bioenergy production, this paper proposed a multi-commodity network flow model to <span class="hlt">design</span> the logistics system for a multiple-feedstock biomass-to-bioenergy industry. The model was formulated as a mixed integer linear programming, determining the locations of warehouses, the size of harvesting team, the <span class="hlt">types</span> and amounts of biomass harvested/purchased, stored, and processed in each month, the transportation of biomass in the system, and so on. This paper demonstrated the advantages of using multiple <span class="hlt">types</span> of biomass feedstocks by comparing with the case of using a single feedstock (switchgrass) and analyzed the relationship of the supply capacity of biomass feedstocks to the output and cost of biofuel. Copyright © 2011 Elsevier Ltd. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24356530','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24356530"><span>Adolescent overweight, obesity and chronic disease-related health practices: mediation by body image.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Farhat, Tilda; Iannotti, Ronald J; Caccavale, Laura J</p> <p>2014-01-01</p> <p>To examine whether body image mediates the association between overweight/obesity and chronic disease-related health practices (CDRHP), including lack of physical activity (PA), infrequent breakfast consumption (<span class="hlt">IBC</span>), screen-based media use (SBM), and smoking. The 2006 Health Behaviors in School-Age Children survey was administered to a nationally representative sample of US students (n = 8,028) in grades 6-10 (mean age = 14.3 years). Outcome variables included self-reported measures of PA, SBM, <span class="hlt">IBC</span>, and smoking. Body image was assessed with 5 items from the Body Investment Scale (α = 0.87) asking for agreement/disagreement with statements about one's body. Stratifying on gender, an initial regression model estimated the association between overweight/obesity and CDRHP. Mediation models that included body image were then compared to the initial model to determine the role of body image in the relationship between overweight/obesity and CDRHP. Among boys, body image mediated the relationships of overweight/obesity with SBM, and of obesity with <span class="hlt">IBC</span>. Among girls, it mediated the relationships of obesity with PA, <span class="hlt">IBC</span>, and smoking, and of overweight with SBM. As the prevalence of overweight/obesity among adolescent boys and girls remains high, efforts to improve their body image could result in less frequent engagement in CDRHP. © 2013 S. Karger GmbH, Freiburg.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16669808','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16669808"><span>E-dating, identity and HIV prevention: theorising sexualities, risk and network society.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Davis, Mark; Hart, Graham; Bolding, Graham; Sherr, Lorraine; Elford, Jonathan</p> <p>2006-05-01</p> <p>This paper addresses how London gay men use the internet to meet sexual partners, or for e-dating. Based on qualitative interviews conducted face-to-face or via the internet, this research develops an account of how information technologies mediate the negotiation of identity and risk in connection with sexual practice. E-dating itself is a bricolage, or heterogeneous DIY practice of internet-based-communication (<span class="hlt">IBC</span>). A central aspect of <span class="hlt">IBC</span> is "filtering" in and out prospective e-dates based on the images and texts used to depict sexual identities. Interpretations and depictions of personal HIV risk management approaches in <span class="hlt">IBC</span> are framed by the meanings of different identities, such as the stigma associated with being HIV positive. This paper argues for a sexualities perspective in a theory of network society. Further, HIV prevention in e-dating can potentially be addressed by considering the interplay of the HIV prevention imperatives associated with different HIV serostatus identities. There is a case for encouraging more explicit <span class="hlt">IBC</span> about risk in e-dating and incorporating the expertise of e-daters in prevention activity. There is also a need to rethink traditional conceptions of risk management in HIV prevention to make space for the risk management bricolage of network society.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3992951','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3992951"><span>Adolescent Overweight, Obesity and Chronic Disease-Related Health Practices: Mediation by Body Image</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Farhat, Tilda; Iannotti, Ronald J.; Caccavale, Laura J.</p> <p>2014-01-01</p> <p>Background/Aims To examine whether body image mediates the association between overweight/obesity and chronic disease-related health practices (CDRHP), including lack of physical activity (PA), infrequent breakfast consumption (<span class="hlt">IBC</span>), screen-based media use (SBM), and smoking. Methods The 2006 Health Behaviors in School-Age Children survey was administered to a nationally representative sample of US students (n = 8,028) in grades 6-10 (mean age = 14.3 years). Outcome variables included self-reported measures of PA, SBM, <span class="hlt">IBC</span>, and smoking. Body image was assessed with 5 items from the Body Investment Scale (α = 0.87) asking for agreement/disagreement with statements about one's body. Stratifying on gender, an initial regression model estimated the association between overweight/obesity and CDRHP. Mediation models that included body image were then compared to the initial model to determine the role of body image in the relationship between overweight/obesity and CDRHP. Results Among boys, body image mediated the relationships of overweight/obesity with SBM, and of obesity with <span class="hlt">IBC</span>. Among girls, it mediated the relationships of obesity with PA, <span class="hlt">IBC</span>, and smoking, and of overweight with SBM. Conclusion As the prevalence of overweight/obesity among adolescent boys and girls remains high, efforts to improve their body image could result in less frequent engagement in CDRHP. PMID:24356530</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29872146','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29872146"><span>Somatic mutations in benign breast disease tissue and risk of subsequent invasive breast cancer.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Rohan, Thomas E; Miller, Christopher A; Li, Tiandao; Wang, Yihong; Loudig, Olivier; Ginsberg, Mindy; Glass, Andrew; Mardis, Elaine</p> <p>2018-06-06</p> <p>Insights into the molecular pathogenesis of breast cancer might come from molecular analysis of tissue from early stages of the disease. We conducted a case-control study nested in a cohort of women who had biopsy-confirmed benign breast disease (BBD) diagnosed between 1971 and 2006 at Kaiser Permanente Northwest and who were followed to mid-2015 to ascertain subsequent invasive breast cancer (<span class="hlt">IBC</span>); cases (n = 218) were women with BBD who developed subsequent <span class="hlt">IBC</span> and controls, individually matched (1:1) to cases, were women with BBD who did not develop <span class="hlt">IBC</span> in the same follow-up interval as that for the corresponding case. Targeted sequence capture and sequencing were performed for 83 genes of importance in breast cancer. There were no significant case-control differences in mutation burden overall, for non-silent mutations, for individual genes, or with respect either to the nature of the gene mutations or to mutational enrichment at the pathway level. For seven subjects with DNA from the BBD and ipsilateral <span class="hlt">IBC</span>, virtually no mutations were shared. This study, the first to use a targeted multi-gene sequencing approach on early breast cancer precursor lesions to investigate the genomic basis of the disease, showed that somatic mutations detected in BBD tissue were not associated with breast cancer risk.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20040031845&hterms=spearing&qs=N%3D0%26Ntk%3DAuthor-Name%26Ntx%3Dmode%2Bmatchall%26Ntt%3Dspearing','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20040031845&hterms=spearing&qs=N%3D0%26Ntk%3DAuthor-Name%26Ntx%3Dmode%2Bmatchall%26Ntt%3Dspearing"><span>Macromolecular Crystallization in Microfluidics for the International Space Station</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Monaco, Lisa A.; Spearing, Scott</p> <p>2003-01-01</p> <p>At NASA's Marshall Space Flight Center, the Iterative Biological Crystallization (<span class="hlt">IBC</span>) project has begun development on scientific hardware for macromolecular crystallization on the International Space Station (ISS). Currently ISS crystallization research is limited to solution recipes that were prepared on the ground prior to launch. The proposed hardware will conduct solution mixing and dispensing on board the ISS, be fully automated, and have imaging functions via remote commanding from the ground. Utilizing microfluidic technology, <span class="hlt">IBC</span> will allow for on orbit iterations. The microfluidics LabChip(R) devices that have been developed, along with Caliper Technologies, will greatly benefit researchers by allowing for precise fluid handling of nano/pico liter sized volumes. <span class="hlt">IBC</span> will maximize the amount of science return by utilizing the microfluidic approach and be a valuable tool to structural biologists investigating medically relevant projects.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20113088','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20113088"><span><span class="hlt">Design</span> and development of indirectly heated solid cathode for strip <span class="hlt">type</span> electron gun.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Maiti, Namita; Mukherjee, S; Kumar, Bhunesh; Barve, U D; Suryawanshi, V B; Das, A K</p> <p>2010-01-01</p> <p><span class="hlt">Design</span> analysis of a high power indirectly heated solid cathode (for a 200 kW, 45 kV, and 270 degrees bent strip <span class="hlt">type</span> electron gun) has been presented. The <span class="hlt">design</span> approach consists of simulation followed by extensive experimentation with different cathode configurations. The preferred cathode is of trapezoidal section (8 x 4 x 2 mm(3)) with an emitting area of 110 x 4 mm(2) made up of tantalum operating at about 2500 K. The solid cathode at the operating temperature of 2500 K generated a well defined electron beam. Electromagnetic and thermomechanical simulation is used to optimize the shape of the beam. Thermal modeling has also been used to analyze the temperature and stress distribution on the electrodes. The simulation results are validated by experimental measurement.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/AD1038249','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/AD1038249"><span><span class="hlt">Design</span> and Fabrication of High-Performance LWIR Photodetectors Based on <span class="hlt">Type</span>-II Superlattices</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2017-08-11</p> <p>SPONSOR/MONITOR’S REPORT Kirtland AFB, NM 87117-5776 NUMBER(S) AFRL -RV-PS-TR-2017-0090 12. DISTRIBUTION / AVAILABILITY STATEMENT Approved for public...unlimited. 13 DISTRIBUTION LIST DTIC/OCP 8725 John J. Kingman Rd, Suite 0944 Ft Belvoir, VA 22060-6218 1 cy AFRL /RVIL Kirtland AFB, NM 87117-5776 2... AFRL -RV-PS- AFRL -RV-PS- TR-2017-0090 TR-2017-0090 <span class="hlt">DESIGN</span> AND FABRICATION OF HIGH- PERFORMANCE LWIR PHOTODETECTORS BASED ON <span class="hlt">TYPE</span>-II SUPERLATTICES</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5673883','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5673883"><span><span class="hlt">Designing</span> a Self-Management App for Young People With <span class="hlt">Type</span> 1 Diabetes: Methodological Challenges, Experiences, and Recommendations</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Reventlov Husted, Gitte; Teilmann, Grete; Hommel, Eva; Olsen, Birthe Susanne; Kensing, Finn</p> <p>2017-01-01</p> <p>Background Young people with <span class="hlt">type</span> 1 diabetes often struggle to self-manage their disease. Mobile health (mHealth) apps show promise in supporting self-management of chronic conditions such as <span class="hlt">type</span> 1 diabetes. Many health care providers become involved in app development. Unfortunately, limited information is available to guide their selection of appropriate methods, techniques, and tools for a participatory <span class="hlt">design</span> (PD) project in health care. Objective The aim of our study was to develop an mHealth app to support young people in self-managing <span class="hlt">type</span> 1 diabetes. This paper presents our methodological recommendations based on experiences and reflections from a 2-year research study. Methods A mixed methods <span class="hlt">design</span> was used to identify user needs before <span class="hlt">designing</span> the app and testing it in a randomized controlled trial. App <span class="hlt">design</span> was based on qualitative, explorative, interventional, and experimental activities within an overall iterative PD approach. Several techniques and tools were used, including workshops, a mail panel, think-aloud tests, and a feasibility study. Results The final mHealth solution was “Young with Diabetes” (YWD). The iterative PD approach supported researchers and <span class="hlt">designers</span> in understanding the needs of end users (ie, young people, parents, and health care providers) and their assessment of YWD, as well as how to improve app usability and feasibility. It is critical to include all end user groups during all phases of a PD project and to establish a multidisciplinary team to provide the wide range of expertise required to build a usable and useful mHealth app. Conclusions Future research is needed to develop and evaluate more efficient PD techniques. Health care providers need guidance on what tools and techniques to choose for which subgroups of users and guidance on how to introduce an app to colleagues to successfully implement an mHealth app in health care organizations. These steps are important for anyone who wants to <span class="hlt">design</span> an mHealth app</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li class="active"><span>20</span></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_20 --> <div id="page_21" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li class="active"><span>21</span></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="401"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017JPhCS.787a2006A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017JPhCS.787a2006A"><span>HTTM - <span class="hlt">Design</span> and Implementation of a <span class="hlt">Type</span>-2 Hypervisor for MIPS64 Based Systems</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ain, Qurrat ul; Anwar, Usama; Mehmood, Muhammad Amir; Waheed, Abdul</p> <p>2017-01-01</p> <p>Virtualization has emerged as an attractive software solution for many problems in server domain. Recently, it has started to enrich embedded systems domain by offering features such as hardware consolidation, security, and isolation. Our objective is to bring virtualization to high-end MIPS64 based systems, such as network routers, switches, wireless base station, etc. For this purpose a <span class="hlt">Type</span>-2 hypervisor is a viable software solution which is easy to deploy and requires no changes in host system. In this paper we present the internal <span class="hlt">design</span> HTTM -A <span class="hlt">Type</span>-2 hypervisor for MIPS64 based systems and demonstrate its functional correctness by using Linux Testing Project (LTP) tests. Finally, we performed LMbench tests for performance evaluation.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016PhDT........93H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016PhDT........93H"><span>Theoretical <span class="hlt">design</span> and material growth of <span class="hlt">Type</span>-II Antimonide-based superlattices for multi-spectral infrared detection and imaging</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Hoang, Anh Minh</p> <p></p> <p>Infrared detectors find applications in many aspects of life, from night vision, target tracking for homeland security and defense, non-destructive failure detection in industry, chemical sensing in medicine, and free-space communication. Currently, the dominant technologies of photodetectors based upon HgCdTe and InSb are experiencing many limitations. Under this circumstance, the <span class="hlt">Type</span>-II InAs/GaSb/AlSb superlattices which have been intensively studied recently appear to be an excellent candidate to give breakthroughs in the infrared technology. The <span class="hlt">Type</span>-II SLs with theirs advantages such as great flexibility in bandgap engineering, high carrier effective mass, Auger recombination suppression and high uniformity have shown excellent device performance from MWIR to VLWIR. In the era of the third generation for infrared cameras, <span class="hlt">Type</span>-II SLs are entering the new phase of development with high performance and multi-spectral detection. The goal of this work is to investigate quantum properties of the superlattice system, <span class="hlt">design</span> appropriate device architectures and experimentally fabricate infrared detectors which can push further the limit of this material system and outperform existing competing technologies. The binary-binary InAs/GaSb superlattice has gone through much transformation over the years. Incorporating compounds lattice matched to the 6.1A family has invited more possibilities to band engineer the <span class="hlt">Type</span>-II SLs. For the first time, by employing all three members of this material system, we have <span class="hlt">designed</span> a new superlattice structure and demonstrated shortwavelength infrared (SWIR) photodiodes based on <span class="hlt">Type</span>-II InAs/GaSb/AlSb with high electrical and optical performance. The photodiodes exhibited a quantum efficiency of 60% with very low dark current, can be operated at room temperature. In addition to the range of MWIR to VLWIR, a new channel of detection has been added to the GaSb based <span class="hlt">type</span>-II SL material system. The new realization of SWIR photodiodes has</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23326849','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23326849"><span><span class="hlt">Design</span> of an efficient Fresnel-<span class="hlt">type</span> lens utilizing double total internal reflection for solar energy collection.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wallhead, Ian; Jiménez, Teresa Molina; Ortiz, Jose Vicente García; Toledo, Ignacio Gonzalez; Toledo, Cristóbal Gonzalez</p> <p>2012-11-05</p> <p>A novel of Fresnel-<span class="hlt">type</span> lens for use as a solar collector has been <span class="hlt">designed</span> which utilizes double total internal reflection (D-TIR) to optimize collection efficiency for high numerical aperture lenses (in the region of 0.3 to 0.6 NA). Results show that, depending on the numerical aperture and the size of the receiver, a collection efficiency theoretical improvement on the order of 20% can be expected with this new <span class="hlt">design</span> compared with that of a conventional Fresnel lens.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25951895','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25951895"><span><span class="hlt">Type</span> synthesis and preliminary <span class="hlt">design</span> of devices supporting lower limb's rehabilitation.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Olinski, Michał; Lewandowski, Bogusz; Gronowicz, Antoni</p> <p>2015-01-01</p> <p>Based on the analysis of existing solutions, biomechanics of human lower limbs and anticipated applications, results of con- siderations concerning the necessary number of degrees of freedom for the <span class="hlt">designed</span> device supporting rehabilitation of lower extremities are presented. An analysis was carried out in order to determine the innovative kinematic structure of the device, ensuring sufficient mobility and functionality while minimizing the number of degrees of freedom. With the aid of appropriate formalised meth- ods, for instance, <span class="hlt">type</span> synthesis, a complete variety of solutions for leg joints were obtained in the form of basic and kinematic schemes, having the potential to find application in devices supporting lower limb rehabilitation. A 3D model of ankle joint module was built in Autodesk Inventor System, then imported to Adams and assembled into a moving numerical model of a mechanism. Several conducted simulations resulted in finding the required maximum stroke of the cylinders. A comparison of the angular ranges of ankle joint and similar devices with the ones achieved by the <span class="hlt">designed</span> device indicated a sufficient reserve allowing not only movements typical of gait, but approximately achieving the passive range of motion for the ankle joint.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/20853651-design-performance-beetle-type-double-tip-scanning-tunneling-microscope','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/20853651-design-performance-beetle-type-double-tip-scanning-tunneling-microscope"><span><span class="hlt">Design</span> and performance of a beetle-<span class="hlt">type</span> double-tip scanning tunneling microscope</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Jaschinsky, Philipp; Coenen, Peter; Pirug, Gerhard</p> <p>2006-09-15</p> <p>A combination of a double-tip scanning tunneling microscope with a scanning electron microscope in ultrahigh vacuum environment is presented. The compact beetle-<span class="hlt">type</span> <span class="hlt">design</span> made it possible to integrate two independently driven scanning tunneling microscopes in a small space. Moreover, an additional level for coarse movement allows the decoupling of the translation and approach of the tunneling tip. The position of the two tips can be controlled from the millimeter scale down to 50 nm with the help of an add-on electron microscope. The instrument is capable of atomic resolution imaging with each tip.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015APLM....3l6101K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015APLM....3l6101K"><span>Toward compositional <span class="hlt">design</span> of reticular <span class="hlt">type</span> porous films by mixing and coating titania-based frameworks with silica</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kimura, T.</p> <p>2015-12-01</p> <p>A recently developed reticular <span class="hlt">type</span> porous structure, which can be fabricated as the film through the soft colloidal block copolymer (e.g., PS-b-PEO) templating, is very promising as the porous platform showing high-performance based on its high surface area as well as high diffusivity of targeted organic molecules and effective accommodation of bulky molecules, but the compositional <span class="hlt">design</span> of oxide frameworks has not been developed so enough to date. Here, I report reliable synthetic methods of the reticular <span class="hlt">type</span> porous structure toward simple compositional variations. Due to the reproducibility of reticular <span class="hlt">type</span> porous titania films from titanium alkoxide (e.g., TTIP; titanium tetraisopropoxide), a titania-silica film having similar porous structure was obtained by mixing silicon alkoxide (e.g., tetraethoxysilane) and TTIP followed by their pre-hydrolysis, and the mixing ratio of Ti to Si composition was easily reached to 1.0. For further compositional <span class="hlt">design</span>, a concept of surface coating was widely applicable; the reticular <span class="hlt">type</span> porous titania surfaces can be coated with other oxides such as silica. Here, a silica coating was successfully achieved by the simple chemical vapor deposition of silicon alkoxide (e.g., tetramethoxysilane) without water (with water at the humidity level), which was also utilized for pore filling with silica by the similar process with water.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2010AIPC.1225..650K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2010AIPC.1225..650K"><span>Conceptual <span class="hlt">Design</span> of a 100kW Energy Integrated <span class="hlt">Type</span> Bi-Directional Tidal Current Turbine</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kim, Ki Pyoung; Ahmed, M. Rafiuddin; Lee, Young Ho</p> <p>2010-06-01</p> <p>The development of a tidal current turbine that can extract maximum energy from the tidal current will be extremely beneficial for supplying continuous electric power. The present paper presents a conceptual <span class="hlt">design</span> of a 100kW energy integrated <span class="hlt">type</span> tidal current turbine for tidal power generation. The instantaneous power density of a flowing fluid incident on an underwater turbine is proportional to the cubic power of current velocity which is approximately 2.5m/s. A cross-flow turbine, provided with a nozzle and a diffuser, is <span class="hlt">designed</span> and analyzed. The potential advantages of ducted and diffuser-augmented turbines were taken into consideration in order to achieve higher output at a relatively low speed. This study looks at a cross-flow turbine system which is placed in an augmentation channel to generate electricity bi-directionally. The compatibility of this turbine system is verified using a commercial CFD code, ANSYSCFX. This paper presents the results of the numerical analysis in terms of pressure, streaklines, velocity vectors and performance curves for energy integrated <span class="hlt">type</span> bi-directional tidal current turbine (BDT) with augmentation.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018MNRAS.476.2629M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018MNRAS.476.2629M"><span>The very young resolved stellar populations around stripped-envelope supernovae</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Maund, Justyn R.</p> <p>2018-05-01</p> <p>The massive star origins for <span class="hlt">Type</span> IIP supernovae (SNe) have been established through direct detection of their red supergiants progenitors in pre-explosion observations; however, there has been limited success in the detection of the progenitors of H-deficient SNe. The final fate of more massive stars, capable of undergoing a Wolf-Rayet phase, and the origins of <span class="hlt">Type</span> <span class="hlt">Ibc</span> SNe remain debated, including the relative importance of single massive star progenitors or lower mass stars stripped in binaries. We present an analysis of the ages and spatial distributions of massive stars around the sites of 23 stripped-envelope SNe, as observed with the Hubble Space Telescope, to probe the possible origins of the progenitors of these events. Using a Bayesian stellar populations analysis scheme, we find characteristic ages for the populations observed within 150 pc of the target <span class="hlt">Type</span> IIb, Ib, and Ic SNe to be log (t) = 7.20, 7.05, and 6.57, respectively. The <span class="hlt">Type</span> Ic SNe in the sample are nearly all observed within 100 pc of young, dense stellar populations. The environment around SN 2002ap is an important exception both in terms of age and spatial properties. These findings may support the hypothesis that stars with Minit > 30 M⊙ produce a relatively large proportion of <span class="hlt">Type</span> <span class="hlt">Ibc</span> SNe, and that these SN subtypes arise from progressively more massive progenitors. Significantly higher extinctions are derived towards the populations hosting these SNe than previously used in analysis of constraints from pre-explosion observations. The large initial masses inferred for the progenitors are in stark contrast with the low ejecta masses estimated from SN light curves.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19760005653','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19760005653"><span>Compressed air demand-<span class="hlt">type</span> firefighter's breathing system, volume 1. [<span class="hlt">design</span> analysis and performance tests</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Sullivan, J. L.</p> <p>1975-01-01</p> <p>The commercial availability of lightweight high pressure compressed air vessels has resulted in a lightweight firefighter's breathing apparatus. The improved apparatus, and details of its <span class="hlt">design</span> and development are described. The apparatus includes a compact harness assembly, a backplate mounted pressure reducer assembly, a lightweight bubble-<span class="hlt">type</span> facemask with a mask mounted demand breathing regulator. Incorporated in the breathing regulator is exhalation valve, a purge valve and a whistle-<span class="hlt">type</span> low pressure warning that sounds only during inhalation. The pressure reducer assembly includes two pressure reducers, an automatic transfer valve and a signaling device for the low pressure warning. Twenty systems were fabricated, tested, refined through an alternating development and test sequence, and extensively examined in a field evaluation program. Photographs of the apparatus are included.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/publication/?seqNo115=348557','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/publication/?seqNo115=348557"><span>Rationale and <span class="hlt">design</span> of the vitamin D and <span class="hlt">type</span> 2 diabetes (D2d) study: a diabetes prevention trial</span></a></p> <p><a target="_blank" href="https://www.ars.usda.gov/research/publications/find-a-publication/">USDA-ARS?s Scientific Manuscript database</a></p> <p></p> <p></p> <p>OBJECTIVE: Observational studies suggest that vitamin D may lower the risk of <span class="hlt">type</span> 2 diabetes. However, data from long-term trials are lacking. The Vitamin D and <span class="hlt">Type</span> 2 Diabetes (D2d) study is a randomized clinical trial <span class="hlt">designed</span> to examine whether a causal relationship exists between vitamin D supp...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2003AIPC..686...74N','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2003AIPC..686...74N"><span>Possible Class of Nearby Gamma-Ray Burst / Gravitational Wave Sources</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Norris, Jay P.</p> <p>2003-10-01</p> <p>A possible subclass of gamma-ray bursts - those with few, wide pulses, spectral lags of order one to several seconds, and soft spectra - has been identified. Their Log[N]-Log[Fp] distribution approximates a -3/2 power-law, suggesting homogeneity and relatively nearby sources. These mostly dim bursts account for ~ 50% of the BATSE sample of long bursts near that instrument's trigger threshold, suggesting that this subluminous class constitutes a more common variety than the more familiar burst sources which lie at truly cosmological distances. Theoretical scenarios predicted such a class, motivated by their exemplar GRB 980425 (SN 1998bw) lying at a distance of ~ 38 Mpc. The observations are explained by invoking off-axis viewing of the GRB jet and/or bulk Lorentz factors of order a few. Long-lag bursts show a tendency to concentrate near the Supergalactic Plane with a quadrupole moment of -0.10 +/- 0.04, similar to that for SNe <span class="hlt">type</span> <span class="hlt">Ib/c</span> within the same volume. The rate of the observed subluminous bursts is of order <fraction><num>1</num><den>4</den></fraction> that of SNe <span class="hlt">Ib/c</span>. Evidence for a sequential relationship between SNe <span class="hlt">Ib/c</span> and GRBs is critiqued for two cases, as simultaneity of the SN and GRB events may be important for detection of the expected gravitational wave signal; at most, SN to GRB delays appear to be a few days. SN asymmetries and ultrarelativistic GRB jets suggest the possibility of rapid rotation in the pre-collapse objects, a primary condition required for highly non-axisymmetric SN collapse to produce strong gravitational waves.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018AIPA....8e6645K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018AIPA....8e6645K"><span><span class="hlt">Design</span> of spoke <span class="hlt">type</span> motor and magnetizer for improving efficiency based rare-earth-free permanent-magnet motor</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kim, Young Hyun; Cheon, Byung Chul; Lee, Jung Ho</p> <p>2018-05-01</p> <p>This study proposes criteria for both optimal-shape and magnetizer-system <span class="hlt">designs</span> to be used for a high-output spoke-<span class="hlt">type</span> motor. The study also examines methods of reducing high-cogging torque and torque ripple, to prevent noise and vibration. The optimal <span class="hlt">design</span> of the stator and rotor can be enhanced using both a response surface method and finite element method. In addition, a magnetizer system is optimally <span class="hlt">designed</span> for the magnetization of permanent magnets for use in the motor. Finally, this study verifies that the proposed motor can efficiently replace interior permanent magnet synchronous motor in many industries.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3062046','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3062046"><span>Recurrent granulomatous mastitis mimicking inflammatory breast cancer</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Ergin, Ahmet Bahadir; Cristofanilli, Massimo; Daw, Hamed; Tahan, Gulgun; Gong, Yun</p> <p>2011-01-01</p> <p>Granulomatous mastitis (GM) is an uncommon benign breast lesion. Diagnosis is a matter of exclusion from other inflammatory, infectious and granulomatous aetiologies. Here, we presented an atypical GM case, which had clinical and radiologic features overlapping with inflammatory breast cancer (<span class="hlt">IBC</span>). The disease had multiple recurrences. The patient is a 40-year-old Caucasian woman with a sudden onset of left breast swelling accompanied by diffuse skin redness, especially of the subareolar region and malodorous yellow nipple discharge from the left nipple. The disease progressed on antibiotic treatment and recurred after local resection. A similar lesion developed even after bilateral mastectomy. GM may show clinical/radiologic features suggestive of <span class="hlt">IBC</span>. Multiple recurrences can be occasionally encountered. GM after recurrence could be much more alarming clinically. Pathology confirmation is the key for accurate diagnosis and a multidisciplinary approach is important to rule out <span class="hlt">IBC</span>. PMID:22715267</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=organization+AND+structure+AND+design&id=EJ1129339','ERIC'); return false;" href="https://eric.ed.gov/?q=organization+AND+structure+AND+design&id=EJ1129339"><span>An Exploratory Study of the Effect of Enclosed Structure on <span class="hlt">Type</span> <span class="hlt">Design</span> with Fixation Dispersion: Evidence from Eye Movements</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Ma, Min-Yuan; Chuang, Hsien-Chih</p> <p>2017-01-01</p> <p><span class="hlt">Type</span> <span class="hlt">design</span> is the process of re-organizing visual elements and their corresponding meanings into a new organic entity, particularly for the highly logographic Chinese characters whose intrinsic features are retained even after re-organization. Due to this advantage, <span class="hlt">designers</span> believe that such a re-organization process will not affect Chinese…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29060992','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29060992"><span>[A systematic review of international simulation models on the natural history of breast cancer: current understanding and challenges for Chinese-population-specific model development].</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ma, H M; Wang, L; Shi, J F; Ying, J M; Zhu, J; Chen, L L; Yue, X P; Gong, J Y; Li, X; Wang, J L; Dai, M</p> <p>2017-10-10</p> <p>Objective: To systematically review the worldwide simulation model studies on the natural history of breast cancer and to summarize related parameters. Methods: A structured literature search was conducted in PubMed and the Cochrane Library to identify articles during 1980-2015. Articles were screened independently by two researchers. Health states in the natural history and relevant parameters were extracted. Results: A total of 36 studies were included for analysis, within the earliest one was published in 1990. Most studies were from Europe and America countries, and 2 studies from China. Markov model was mostly applied to evaluating breast cancer screening programs ( n =32). Reported health status included "healthy" ( n =36), ductal carcinoma in situ (DCIS, n =17), invasive breast cancer (<span class="hlt">IBC</span>, n =36), and death ( n =27). There were two definite classifications for <span class="hlt">IBC</span>, tumor size ( n =9) and TNM staging ( n =9, 3 studies reported transition rates). The median (range) of annual transition rates from DCIS to stage-Ⅰ <span class="hlt">IBC</span>, Ⅰ to Ⅱ, Ⅱ to Ⅲ, Ⅲ to Ⅳ were 0.279 (0.259-0.299), 0.150 (0.069-0.430), 0.100 (0.060-0.128) and 0.210 (0.010-0.625), respectively. A total of 15 studies reported the mean duration from predinical to clinical stage for <span class="hlt">IBC</span> was 1.95-4.70 years, which gradually increased with age, and 7 studies reported that for DCIS. Conclusions: Despite closer attention was paid to breast cancer natural history models, in recent years atypical hyperplasia has been neglected. Data on the mean duration of DCIS requires reasonable conversion. Various classifications for <span class="hlt">IBC</span> exist whereas transition rates are limited. Current findings would be valuable references but challenging for the Chinese-population specific natural history model, development.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018JPhCS1015c2043G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018JPhCS1015c2043G"><span>Use of information technologies when <span class="hlt">designing</span> multilayered plates and covers with filler of various <span class="hlt">types</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Golova, T. A.; Magerramova, I. A.; Ivanov, S. A.</p> <p>2018-05-01</p> <p>Calculation of multilayered plates and covers does not consider anisotropic properties of a construction. Calculation comes down to uniform isotropic covers and definition of one of intense and deformation conditions of constructions. The existing techniques consider work of multilayered <span class="hlt">designs</span> by means of various coefficients. The article describes the optimized algorithm of operations when <span class="hlt">designing</span> multilayered plates and covers with filler of various <span class="hlt">types</span> on the basis of the conducted researches. It is dealt with a development engineering algorithm of calculation of multi-layer constructions of walls. Software is created which allows one to carry out assessment of intense and deformation conditions of constructions of walls.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29061552','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29061552"><span><span class="hlt">Designing</span> a Self-Management App for Young People With <span class="hlt">Type</span> 1 Diabetes: Methodological Challenges, Experiences, and Recommendations.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Castensøe-Seidenfaden, Pernille; Reventlov Husted, Gitte; Teilmann, Grete; Hommel, Eva; Olsen, Birthe Susanne; Kensing, Finn</p> <p>2017-10-23</p> <p>Young people with <span class="hlt">type</span> 1 diabetes often struggle to self-manage their disease. Mobile health (mHealth) apps show promise in supporting self-management of chronic conditions such as <span class="hlt">type</span> 1 diabetes. Many health care providers become involved in app development. Unfortunately, limited information is available to guide their selection of appropriate methods, techniques, and tools for a participatory <span class="hlt">design</span> (PD) project in health care. The aim of our study was to develop an mHealth app to support young people in self-managing <span class="hlt">type</span> 1 diabetes. This paper presents our methodological recommendations based on experiences and reflections from a 2-year research study. A mixed methods <span class="hlt">design</span> was used to identify user needs before <span class="hlt">designing</span> the app and testing it in a randomized controlled trial. App <span class="hlt">design</span> was based on qualitative, explorative, interventional, and experimental activities within an overall iterative PD approach. Several techniques and tools were used, including workshops, a mail panel, think-aloud tests, and a feasibility study. The final mHealth solution was "Young with Diabetes" (YWD). The iterative PD approach supported researchers and <span class="hlt">designers</span> in understanding the needs of end users (ie, young people, parents, and health care providers) and their assessment of YWD, as well as how to improve app usability and feasibility. It is critical to include all end user groups during all phases of a PD project and to establish a multidisciplinary team to provide the wide range of expertise required to build a usable and useful mHealth app. Future research is needed to develop and evaluate more efficient PD techniques. Health care providers need guidance on what tools and techniques to choose for which subgroups of users and guidance on how to introduce an app to colleagues to successfully implement an mHealth app in health care organizations. These steps are important for anyone who wants to <span class="hlt">design</span> an mHealth app for any illness. ©Pernille Castens</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3361561','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3361561"><span>A Comparison of Two Internet Programs for Adolescents with <span class="hlt">Type</span> 1 Diabetes: <span class="hlt">Design</span> and Methods</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Grey, Margaret; Whittemore, Robin; Liberti, Lauren; Delamater, Alan; Murphy, Kathryn; Faulkner, Melissa S.</p> <p>2012-01-01</p> <p>Implementing psycho-educational programs for youth with <span class="hlt">type</span> 1 diabetes in clinical care and reaching diverse youth with <span class="hlt">type</span> 1 diabetes is challenging due to youth, provider, and organizational barriers. This study was <span class="hlt">designed</span> to compare the effectiveness of an internet coping skills training program with a control condition of internet diabetes education. Each program consists of 5 weekly interactive lessons; the coping skills training program also provides the ability for youth to interact with each other as well as a health coach. Approximately 300 youth with <span class="hlt">type</span> 1 diabetes will be recruited to participate in this multi-site clinical trial. The primary outcomes are metabolic control, quality of life, and family conflict. Secondary outcomes include stress, coping, self-efficacy, and social competence. Usage, satisfaction, and cost will also be evaluated. In addition, mediators and moderators to intervention effects will be explored. An internet based psycho-educational program for youth with <span class="hlt">type</span> 1 diabetes may be a promising approach that can be easily be integrated into clinical care. PMID:22484337</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19780021410','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19780021410"><span><span class="hlt">Design</span> of space-<span class="hlt">type</span> electronic power transformers</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Ahearn, J. F.; Lagadinos, J. C.</p> <p>1977-01-01</p> <p>Both open and encapsulated varieties of high reliability, low weight, and high efficiency moderate and high voltage transformers were investigated to determine the advantages and limitations of their construction in the ranges of power and voltage required for operation in the hard vacuum environment of space. Topics covered include: (1) selection of the core material; (2) preliminary calculation of core dimensions; (3) selection of insulating materials including magnet wire insulation, coil forms, and layer and interwinding insulation; (4) coil <span class="hlt">design</span>; (5) calculation of copper losses, core losses and efficiency; (6) calculation of temperature rise; and (7) optimization of <span class="hlt">design</span> with changes in core selection or coil <span class="hlt">design</span> as required to meet specifications.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20030004235','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20030004235"><span><span class="hlt">Design</span>, Fabrication, and Testing of Composite Energy-Absorbing Keel Beams for General Aviation <span class="hlt">Type</span> Aircraft</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Kellas, Sotiris; Knight, Norman F., Jr.</p> <p>2002-01-01</p> <p>A lightweight energy-absorbing keel-beam concept was developed and retrofitted in a general aviation <span class="hlt">type</span> aircraft to improve crashworthiness performance. The energy-absorbing beam consisted of a foam-filled cellular structure with glass fiber and hybrid glass/kevlar cell walls. <span class="hlt">Design</span>, analysis, fabrication and testing of the keel beams prior to installation and subsequent full-scale crash testing of the aircraft are described. Factors such as material and fabrication constraints, damage tolerance, crush stress/strain response, seat-rail loading, and post crush integrity, which influenced the course of the <span class="hlt">design</span> process are also presented. A theory similar to the one often used for ductile metal box structures was employed with appropriate modifications to estimate the sustained crush loads for the beams. This, analytical tool, coupled with dynamic finite element simulation using MSC.Dytran were the prime <span class="hlt">design</span> and analysis tools. The validity of the theory as a reliable <span class="hlt">design</span> tool was examined against test data from static crush tests of beam sections while the overall performance of the energy-absorbing subfloor was assessed through dynamic testing of 24 in long subfloor assemblies.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li class="active"><span>21</span></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_21 --> <div id="page_22" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li class="active"><span>22</span></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="421"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27376306','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27376306"><span><span class="hlt">Design</span> of Diaphragm and Coil for Stable Performance of an Eddy Current <span class="hlt">Type</span> Pressure Sensor.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lee, Hyo Ryeol; Lee, Gil Seung; Kim, Hwa Young; Ahn, Jung Hwan</p> <p>2016-07-01</p> <p>The aim of this work was to develop an eddy current <span class="hlt">type</span> pressure sensor and investigate its fundamental characteristics affected by the mechanical and electrical <span class="hlt">design</span> parameters of sensor. The sensor has two key components, i.e., diaphragm and coil. On the condition that the outer diameter of sensor is 10 mm, two key parts should be <span class="hlt">designed</span> so as to keep a good linearity and sensitivity. Experiments showed that aluminum is the best target material for eddy current detection. A round-grooved diaphragm is suggested in order to measure more precisely its deflection caused by applied pressures. The <span class="hlt">design</span> parameters of a round-grooved diaphragm can be selected depending on the measuring requirements. A developed pressure sensor with diaphragm of t = 0.2 mm and w = 1.05 mm was verified to measure pressure up to 10 MPa with very good linearity and errors of less than 0.16%.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23744306','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23744306"><span>The use of intermediate endpoints in the <span class="hlt">design</span> of <span class="hlt">type</span> 1 diabetes prevention trials.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Krischer, Jeffrey P</p> <p>2013-09-01</p> <p>This paper presents a rationale for the selection of intermediate endpoints to be used in the <span class="hlt">design</span> of <span class="hlt">type</span> 1 diabetes prevention clinical trials. Relatives of individuals diagnosed with <span class="hlt">type</span> 1 diabetes were enrolled on the TrialNet Natural History Study and screened for diabetes-related autoantibodies. Those with two or more such autoantibodies were analysed with respect to increased HbA1c, decreased C-peptide following an OGTT, or abnormal OGTT values as intermediate markers of disease progression. Over 2 years, a 10% increase in HbA1c, and a 20% or 30% decrease in C-peptide from baseline, or progression to abnormal OGTT, occurred with a frequency between 20% and 41%. The 3- to 5-year risk of <span class="hlt">type</span> 1 diabetes following each intermediate endpoint was high, namely 47% to 84%. The lower the incidence of the endpoint being reached, the higher the risk of diabetes. A diabetes prevention trial using these intermediate endpoints would require a 30% to 50% smaller sample size than one using <span class="hlt">type</span> 1 diabetes as the endpoint. The use of an intermediate endpoint in diabetes prevention is based on the generally held view of disease progression from initial occurrence of autoantibodies through successive immunological and metabolic changes to manifest <span class="hlt">type</span> 1 diabetes. Thus, these markers are suitable for randomised phase 2 trials, which can more rapidly screen promising new therapies, allowing them to be subsequently confirmed in definitive phase 3 trials.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015SMaS...24h5009S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015SMaS...24h5009S"><span>Optimal <span class="hlt">design</span> of disc-<span class="hlt">type</span> magneto-rheological brake for mid-sized motorcycle: experimental evaluation</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Sohn, Jung Woo; Jeon, Juncheol; Nguyen, Quoc Hung; Choi, Seung-Bok</p> <p>2015-08-01</p> <p>In this paper, a disc-<span class="hlt">type</span> magneto-rheological (MR) brake is <span class="hlt">designed</span> for a mid-sized motorcycle and its performance is experimentally evaluated. The proposed MR brake consists of an outer housing, a rotating disc immersed in MR fluid, and a copper wire coiled around a bobbin to generate a magnetic field. The structural configuration of the MR brake is first presented with consideration of the installation space for the conventional hydraulic brake of a mid-sized motorcycle. The <span class="hlt">design</span> parameters of the proposed MR brake are optimized to satisfy <span class="hlt">design</span> requirements such as the braking torque, total mass of the MR brake, and cruising temperature caused by the magnetic-field friction of the MR fluid. In the optimization procedure, the braking torque is calculated based on the Herschel-Bulkley rheological model, which predicts MR fluid behavior well at high shear rate. An optimization tool based on finite element analysis is used to obtain the optimized dimensions of the MR brake. After manufacturing the MR brake, mechanical performances regarding the response time, braking torque and cruising temperature are experimentally evaluated.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018MPAG...21...12L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018MPAG...21...12L"><span>Particle Creation at a Point Source by Means of Interior-Boundary Conditions</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Lampart, Jonas; Schmidt, Julian; Teufel, Stefan; Tumulka, Roderich</p> <p>2018-06-01</p> <p>We consider a way of defining quantum Hamiltonians involving particle creation and annihilation based on an interior-boundary condition (<span class="hlt">IBC</span>) on the wave function, where the wave function is the particle-position representation of a vector in Fock space, and the <span class="hlt">IBC</span> relates (essentially) the values of the wave function at any two configurations that differ only by the creation of a particle. Here we prove, for a model of particle creation at one or more point sources using the Laplace operator as the free Hamiltonian, that a Hamiltonian can indeed be rigorously defined in this way without the need for any ultraviolet regularization, and that it is self-adjoint. We prove further that introducing an ultraviolet cut-off (thus smearing out particles over a positive radius) and applying a certain known renormalization procedure (taking the limit of removing the cut-off while subtracting a constant that tends to infinity) yields, up to addition of a finite constant, the Hamiltonian defined by the <span class="hlt">IBC</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26105027','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26105027"><span>To core, or not to core: the impact of coring on tree health and a best-practice framework for collecting dendrochronological information from living trees.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Tsen, Edward W J; Sitzia, Tommaso; Webber, Bruce L</p> <p>2016-11-01</p> <p>Trees are natural repositories of valuable environmental information that is preserved in the growth and structure of their stems, branches and roots. Dendrochronological analyses, based on the counting, crossdating and characterisation of incrementally formed wood rings, offer powerful insights for diverse fields including ecology, climatology and archaeology. The application of this toolset is likely to increase in popularity over coming decades due to advances in the field and a reduction in the cost of analyses. In research settings where the continued value of living trees subject to dendrochronological investigation is important, the use of an increment bore corer to extract trunk tissue is considered the best option to minimise negative impacts on tree health (e.g. stress and fitness). A small and fragmented body of literature, however, reports significant after-effects, and in some cases fatal outcomes, from this sampling technique. As it stands, the literature documenting increment bore coring (<span class="hlt">IBC</span>) impacts lacks experimental consistency and is poorly replicated, making it difficult for prospective users of the method to assess likely tree responses to coring. This paucity of information has the potential to lead to destructive misuse of the method and also limits its safe implementation in circumstances where the risk of impacts may be appropriate. If <span class="hlt">IBC</span> is to fulfil its potential as a method of choice across research fields, then we must first address our limited understanding of <span class="hlt">IBC</span> impacts and provide a framework for its appropriate future use. Firstly, we review the historical context of studies examining the impacts of <span class="hlt">IBC</span> on trees to identify known patterns, focal issues and biases in existing knowledge. <span class="hlt">IBC</span> wound responses, particularly those that impact on lumber quality, have been the primary focus of prior studies. No universal treatment was identified that conclusively improved wound healing and few studies have linked wound responses to tree</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20368809','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20368809"><span>Actuating mechanism and <span class="hlt">design</span> of a cylindrical traveling wave ultrasonic motor using cantilever <span class="hlt">type</span> composite transducer.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Liu, Yingxiang; Chen, Weishan; Liu, Junkao; Shi, Shengjun</p> <p>2010-04-02</p> <p>Ultrasonic motors (USM) are based on the concept of driving the rotor by a mechanical vibration excited on the stator via piezoelectric effect. USM exhibit merits such as simple structure, quick response, quiet operation, self-locking when power off, nonelectromagnetic radiation and higher position accuracy. A cylindrical <span class="hlt">type</span> traveling wave ultrasonic motor using cantilever <span class="hlt">type</span> composite transducer was proposed in this paper. There are two cantilevers on the outside surface of cylinder, four longitudinal PZT ceramics are set between the cantilevers, and four bending PZT ceramics are set on each outside surface of cantilevers. Two degenerate flexural vibration modes spatially and temporally orthogonal to each other in the cylinder are excited by the composite transducer. In this new <span class="hlt">design</span>, a single transducer can excite a flexural traveling wave in the cylinder. Thus, elliptical motions are achieved on the teeth. The actuating mechanism of proposed motor was analyzed. The stator was <span class="hlt">designed</span> with FEM. The two vibration modes of stator were degenerated. Transient analysis was developed to gain the vibration characteristic of stator, and results indicate the motion trajectories of nodes on the teeth are nearly ellipses. The study results verify the feasibility of the proposed <span class="hlt">design</span>. The wave excited in the cylinder isn't an ideal traveling wave, and the vibration amplitudes are inconsistent. The distortion of traveling wave is generated by the deformation of bending vibration mode of cylinder, which is caused by the coupling effect between the cylinder and transducer. Analysis results also prove that the objective motions of nodes on the teeth are three-dimensional vibrations. But, the vibration in axial direction is minute compared with the vibrations in circumferential and radial direction. The results of this paper can guide the development of this new <span class="hlt">type</span> of motor.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2848863','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2848863"><span>Actuating Mechanism and <span class="hlt">Design</span> of a Cylindrical Traveling Wave Ultrasonic Motor Using Cantilever <span class="hlt">Type</span> Composite Transducer</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Liu, Yingxiang; Chen, Weishan; Liu, Junkao; Shi, Shengjun</p> <p>2010-01-01</p> <p>Background Ultrasonic motors (USM) are based on the concept of driving the rotor by a mechanical vibration excited on the stator via piezoelectric effect. USM exhibit merits such as simple structure, quick response, quiet operation, self-locking when power off, nonelectromagnetic radiation and higher position accuracy. Principal Findings A cylindrical <span class="hlt">type</span> traveling wave ultrasonic motor using cantilever <span class="hlt">type</span> composite transducer was proposed in this paper. There are two cantilevers on the outside surface of cylinder, four longitudinal PZT ceramics are set between the cantilevers, and four bending PZT ceramics are set on each outside surface of cantilevers. Two degenerate flexural vibration modes spatially and temporally orthogonal to each other in the cylinder are excited by the composite transducer. In this new <span class="hlt">design</span>, a single transducer can excite a flexural traveling wave in the cylinder. Thus, elliptical motions are achieved on the teeth. The actuating mechanism of proposed motor was analyzed. The stator was <span class="hlt">designed</span> with FEM. The two vibration modes of stator were degenerated. Transient analysis was developed to gain the vibration characteristic of stator, and results indicate the motion trajectories of nodes on the teeth are nearly ellipses. Conclusions The study results verify the feasibility of the proposed <span class="hlt">design</span>. The wave excited in the cylinder isn't an ideal traveling wave, and the vibration amplitudes are inconsistent. The distortion of traveling wave is generated by the deformation of bending vibration mode of cylinder, which is caused by the coupling effect between the cylinder and transducer. Analysis results also prove that the objective motions of nodes on the teeth are three-dimensional vibrations. But, the vibration in axial direction is minute compared with the vibrations in circumferential and radial direction. The results of this paper can guide the development of this new <span class="hlt">type</span> of motor. PMID:20368809</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/17668658','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/17668658"><span>SVM-based tree-<span class="hlt">type</span> neural networks as a critic in adaptive critic <span class="hlt">designs</span> for control.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Deb, Alok Kanti; Jayadeva; Gopal, Madan; Chandra, Suresh</p> <p>2007-07-01</p> <p>In this paper, we use the approach of adaptive critic <span class="hlt">design</span> (ACD) for control, specifically, the action-dependent heuristic dynamic programming (ADHDP) method. A least squares support vector machine (SVM) regressor has been used for generating the control actions, while an SVM-based tree-<span class="hlt">type</span> neural network (NN) is used as the critic. After a failure occurs, the critic and action are retrained in tandem using the failure data. Failure data is binary classification data, where the number of failure states are very few as compared to the number of no-failure states. The difficulty of conventional multilayer feedforward NNs in learning this <span class="hlt">type</span> of classification data has been overcome by using the SVM-based tree-<span class="hlt">type</span> NN, which due to its feature to add neurons to learn misclassified data, has the capability to learn any binary classification data without a priori choice of the number of neurons or the structure of the network. The capability of the trained controller to handle unforeseen situations is demonstrated.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title49-vol3/pdf/CFR-2011-title49-vol3-sec192-175.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title49-vol3/pdf/CFR-2011-title49-vol3-sec192-175.pdf"><span>49 CFR 192.175 - Pipe-<span class="hlt">type</span> and bottle-<span class="hlt">type</span> holders.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-10-01</p> <p>... 49 Transportation 3 2011-10-01 2011-10-01 false Pipe-<span class="hlt">type</span> and bottle-<span class="hlt">type</span> holders. 192.175 Section....175 Pipe-<span class="hlt">type</span> and bottle-<span class="hlt">type</span> holders. (a) Each pipe-<span class="hlt">type</span> and bottle-<span class="hlt">type</span> holder must be <span class="hlt">designed</span> so... equipment, that might cause corrosion or interfere with the safe operation of the holder. (b) Each pipe-<span class="hlt">type</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol3/pdf/CFR-2010-title49-vol3-sec192-175.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title49-vol3/pdf/CFR-2010-title49-vol3-sec192-175.pdf"><span>49 CFR 192.175 - Pipe-<span class="hlt">type</span> and bottle-<span class="hlt">type</span> holders.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... 49 Transportation 3 2010-10-01 2010-10-01 false Pipe-<span class="hlt">type</span> and bottle-<span class="hlt">type</span> holders. 192.175 Section....175 Pipe-<span class="hlt">type</span> and bottle-<span class="hlt">type</span> holders. (a) Each pipe-<span class="hlt">type</span> and bottle-<span class="hlt">type</span> holder must be <span class="hlt">designed</span> so... equipment, that might cause corrosion or interfere with the safe operation of the holder. (b) Each pipe-<span class="hlt">type</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26489030','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26489030"><span>Genetic Predictors of Depressive Symptoms in the Look AHEAD Trial.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>McCaffery, Jeanne M; Papandonatos, George D; Faulconbridge, Lucy F; Erar, Bahar; Peter, Inga; Wagenknecht, Lynne E; Pajewski, Nicholas M; Anderson, Andrea; Wadden, Thomas A; Wing, Rena R</p> <p>2015-01-01</p> <p>Numerous studies have found elevated depressive symptoms among individuals with <span class="hlt">Type</span> 2 diabetes, yet the mechanisms remain unclear. We examined whether genetic loci previously associated with depressive symptoms predict depressive symptoms among overweight/obese individuals with <span class="hlt">Type</span> 2 diabetes or change in depressive symptoms during behavioral weight loss. The Illumina CARe iSelect (<span class="hlt">IBC</span>) chip and Cardiometabochip were characterized in 2118 overweight or obese participants with <span class="hlt">Type</span> 2 diabetes from Look AHEAD (Action for Health in Diabetes), a randomized trial to determine the effects of intensive life-style intervention and diabetes support and education on cardiovascular morbidity and mortality. Primary analyses focused on baseline Beck Depression Inventory (BDI) scores and depressive symptom change at 1 year. Of eight single nucleotide polymorphisms (SNPs) in six loci, three a priori SNPs in two loci (chromosome 5: rs60271; LBR: rs2230419, rs1011319) were associated with baseline BDI scores, but in the opposite direction of prior research. In joint analysis of 90,003 <span class="hlt">IBC</span> and Cardiometabochip SNPs, rs1543654 in the region of KCNE1 predicted change in BDI scores at Year 1 in diabetes support and education (β = -1.05, standard error [SE] = 0.21, p = 6.9 × 10(-7)) at the level of chip-wide significance, while also showing a nominal association with baseline BDI (β = 0.35, SE = 0.16, p = .026). Adjustment for antidepressant medication and/or limiting analyses to non-Hispanic white individuals did not meaningfully alter results. Previously reported genetic associations with depressive symptoms did not replicate in this cohort of overweight/obese individuals with <span class="hlt">Type</span> 2 diabetes. We identified KCNE1 as a potential novel locus associated with depressive symptoms.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28538297','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28538297"><span>Effect of Game <span class="hlt">Design</span>, Goal <span class="hlt">Type</span>, and Player Numbers on the Physiological and Physical Demands of Hurling-Specific Small-Sided Games.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Malone, Shane; Collins, Kieran D</p> <p>2017-06-01</p> <p>The current study examined the effect that game <span class="hlt">design</span> modification, goal <span class="hlt">type</span>, and player numbers on the running performance and physiological demands of small-sided hurling games (SSG). Forty-eight hurling players (age, 25.5 ± 3.2 years; height, 178.9 ± 3.2 cm; body mass, 78.5 ± 4.5 kg) performed 4 <span class="hlt">types</span> of SSG (possession [P], normal play [NP], regular goals [RG] and small goals [SG]) in 4-a-side, 5-a-side, and 6-a-side formats. Heart rate (Polar Electro Oy) and global positioning system technology (VX Sport, 4-Hz, Lower Hutt) were used to analyze the physical and physiological differences between SSG. Total distance (m), high-speed running distance (m) (≥17 km·h), very-high speed running distance (≥22 km·h) (m), peak and mean velocity (km·h) were analyzed as an indicator of the physical demands of play. The 4-a-side SSG independent of game <span class="hlt">design</span> and goal <span class="hlt">type</span> resulted in a significantly higher relative exercise intensity compared with 5-a-side (mean change: 6 ± 2%; p = 0.001; d = 1.9 ± 0.2; large) and 6-a-side SSG independent of game <span class="hlt">design</span> or goal <span class="hlt">type</span> (mean change: 12 ± 2%; p = 0.001; d = 2.9 ± 0.8; very large). The 4-a-side SG (619 ± 106-m [419-735-m]) resulted in the highest distance when compared with all PP (mean change: 141 ± 9 m; p = 0.05; d = 1.9 ± 0.3; moderate) and RG (mean change: 119 ± 39 m; p = 0.004; d = 2.1 ± 0.8; large). Similar trends were observed for 5-a-side and 6-a-side games with SG resulting in increased total running performance. In conclusion, the current observations reveal that 4-a-side NP, SG, and RG have the highest physiological demands with 4-a-side SG having increased running performance in contrast to other game <span class="hlt">design</span> and goal-<span class="hlt">type</span> games. Furthermore, independent of game <span class="hlt">design</span> and goal <span class="hlt">type</span>, 4-a-side SSG show increased relative intensity compared with 5-a-side and 6-a-side SSG.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5817223','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5817223"><span>Proposal to <span class="hlt">designate</span> the order Actinomycetales Buchanan 1917, 162 (Approved Lists 1980) as the nomenclatural <span class="hlt">type</span> of the class Actinobacteria. Request for an Opinion</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2017-01-01</p> <p>The name of the class Actinobacteria is illegitimate according to Rules 15, 22 and 27(3) because it was proposed without the <span class="hlt">designation</span> of a nomenclatural <span class="hlt">type</span>. I therefore propose to <span class="hlt">designate</span> the order Actinomycetales Buchanan 1917, 162 (Approved Lists 1980) as its nomenclatural <span class="hlt">type</span>, based on Rule 22 of the International Code of Nomenclature of Prokaryotes. PMID:28840812</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28840812','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28840812"><span>Proposal to <span class="hlt">designate</span> the order Actinomycetales Buchanan 1917, 162 (Approved Lists 1980) as the nomenclatural <span class="hlt">type</span> of the class Actinobacteria. Request for an Opinion.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Oren, Aharon</p> <p>2017-09-01</p> <p>The name of the class Actinobacteria is illegitimate according to Rules 15, 22 and 27(3) because it was proposed without the <span class="hlt">designation</span> of a nomenclatural <span class="hlt">type</span>. I therefore propose to <span class="hlt">designate</span> the order Actinomycetales Buchanan 1917, 162 (Approved Lists 1980) as its nomenclatural <span class="hlt">type</span>, based on Rule 22 of the International Code of Nomenclature of Prokaryotes.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/20849773-design-performance-front-steering-type-electron-cyclotron-launcher-iter','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/20849773-design-performance-front-steering-type-electron-cyclotron-launcher-iter"><span><span class="hlt">Design</span> Performance of Front Steering-<span class="hlt">Type</span> Electron Cyclotron Launcher for ITER</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Takahashi, K.; Imai, T.; Kobayashi, N.</p> <p>2005-01-15</p> <p>The performance of a front steering (FS)-<span class="hlt">type</span> electron cyclotron launcher <span class="hlt">designed</span> for the International Thermonuclear Experimental Reactor (ITER) is evaluated with a thermal, electromagnetic, and nuclear analysis of the components; a mechanical test of a spiral tube for the steering mirror; and a rotational test of bearings. The launcher consists of a front shield and a launcher plug where three movable optic mirrors to steer incident multimegawatt radio-frequency beam power, waveguide components, nuclear shields, and vacuum windows are installed. The windows are located behind a closure plate to isolate the transmission lines from the radioactivated circumstance (vacuum vessel). The waveguidemore » lines of the launcher are doglegged to reduce the direct neutron streaming toward the vacuum windows and other components. The maximum stresses on the critical components such as the steering mirror, its cooling tube, and the front shield are less than their allowable stresses. It was also identified that the stress on the launcher, which yielded from electromagnetic force caused by plasma disruption, was a little larger than the criteria, and a modification of the launcher plug structure was necessary. The nuclear analysis result shows that the neutron shield capability of the launcher satisfies the shield criteria of the ITER. It concludes that the <span class="hlt">design</span> of the FS launcher is generally suitable for application to the ITER.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/11353095','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/11353095"><span>The rational <span class="hlt">design</span> of a '<span class="hlt">type</span> 88' genetically stable peptide display vector in the filamentous bacteriophage fd.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Enshell-Seijffers, D; Smelyanski, L; Gershoni, J M</p> <p>2001-05-15</p> <p>Filamentous bacteriophages are particularly efficient for the expression and display of combinatorial random peptides. Two phage proteins are often employed for peptide display: the infectivity protein, PIII, and the major coat protein, PVIII. The use of PVIII typically requires the expression of two pVIII genes: the wild-<span class="hlt">type</span> and the recombinant pVIII gene, to generate mosaic phages. '<span class="hlt">Type</span> 88' vectors contain two pVIII genes in one phage genome. In this study a novel '<span class="hlt">type</span> 88' expression vector has been rationally <span class="hlt">designed</span> and constructed. Two factors were taken into account: the insertion site and the genetic stability of the second pVIII gene. It was found that selective deletion of recombinant genes was encountered when inserts were cloned into either of the two non-coding regions of the phage genome. The deletions were independent of recA yet required a functional F-episome. Transcription was also found to be a positive factor for deletion. Taking the above into account led to the generation of a novel vector, <span class="hlt">designated</span> fth1, which can be used to express recombinant peptides as pVIII chimeric proteins in mosaic bacteriophages. The fth1 vector is not only genetically stable but also of high copy number and produces high titers of recombinant phages.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3743228','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3743228"><span>The use of intermediate endpoints in the <span class="hlt">design</span> of <span class="hlt">type</span> 1 diabetes prevention trials</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Krischer, Jeffrey P.</p> <p>2013-01-01</p> <p>Aims/hypothesis This paper presents a rationale for the selection of intermediate endpoints to be used in the <span class="hlt">design</span> of <span class="hlt">type</span> 1 diabetes prevention clinical trials. Methods Relatives of individuals diagnosed with <span class="hlt">type</span> 1 diabetes were enrolled on the TrialNet Natural History Study and screened for diabetes-related autoantibodies. Those with two or more such autoantibodies were analysed with respect to increased HbA1c, decreased C-peptide following an OGTT, or abnormal OGTT values as intermediate markers of disease progression. Results Over 2 years, a 10% increase in HbA1c, and a 20% or 30% decrease in C-peptide from baseline, or progression to abnormal OGTT, occurred with a frequency between 20% and 41%. The 3- to 5-year risk of <span class="hlt">type</span> 1 diabetes following each intermediate endpoint was high, namely 47% to 84%. The lower the incidence of the endpoint being reached, the higher the risk of diabetes. A diabetes prevention trial using these intermediate endpoints would require a 30% to 50% smaller sample size than one using <span class="hlt">type</span> 1 diabetes as the endpoint. Conclusions/interpretation The use of an intermediate endpoint in diabetes prevention is based on the generally held view of disease progression from initial occurrence of autoantibodies through successive immunological and metabolic changes to manifest <span class="hlt">type</span> 1 diabetes. Thus, these markers are suitable for randomised phase 2 trials, which can more rapidly screen promising new therapies, allowing them to be subsequently confirmed in definitive phase 3 trials. PMID:23744306</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=managerial+AND+accounting&pg=2&id=ED555124','ERIC'); return false;" href="https://eric.ed.gov/?q=managerial+AND+accounting&pg=2&id=ED555124"><span>The Effect of Prior Knowledge and Feedback <span class="hlt">Type</span> <span class="hlt">Design</span> on Student Achievement and Satisfaction in Introductory Accounting</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Campbell, Donald P.</p> <p>2013-01-01</p> <p>This study investigated the effect of student prior knowledge and feedback <span class="hlt">type</span> on student achievement and satisfaction in an introductory managerial accounting course using computer-based formative assessment tools. The study involved a redesign of the existing Job Order Costing unit using the ADDIE model of instructional <span class="hlt">design</span>. The…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21724520','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21724520"><span>Quasi-static modeling of human limb for intra-body communications with experiments.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Pun, Sio Hang; Gao, Yue Ming; Mak, PengUn; Vai, Mang I; Du, Min</p> <p>2011-11-01</p> <p>In recent years, the increasing number of wearable devices on human has been witnessed as a trend. These devices can serve for many purposes: personal entertainment, communication, emergency mission, health care supervision, delivery, etc. Sharing information among the devices scattered across the human body requires a body area network (BAN) and body sensor network (BSN). However, implementation of the BAN/BSN with the conventional wireless technologies cannot give optimal result. It is mainly because the high requirements of light weight, miniature, energy efficiency, security, and less electromagnetic interference greatly limit the resources available for the communication modules. The newly developed intra-body communication (<span class="hlt">IBC</span>) can alleviate most of the mentioned problems. This technique, which employs the human body as a communication channel, could be an innovative networking method for sensors and devices on the human body. In order to encourage the research and development of the <span class="hlt">IBC</span>, the authors are favorable to lay a better and more formal theoretical foundation on <span class="hlt">IBC</span>. They propose a multilayer mathematical model using volume conductor theory for galvanic coupling <span class="hlt">IBC</span> on a human limb with consideration on the inhomogeneous properties of human tissue. By introducing and checking with quasi-static approximation criteria, Maxwell's equations are decoupled and capacitance effect is included to the governing equation for further improvement. Finally, the accuracy and potential of the model are examined from both in vitro and in vivo experimental results.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014ESASP.719E..26S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014ESASP.719E..26S"><span>Study of a Secondary Power System Based on an Intermediate Bus Converter and POLs</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Santoja, Almudena; Fernandez, Arturo; Tonicello, Ferdinando</p> <p>2014-08-01</p> <p>Secondary power systems in satellites are everything but standard nowadays. All sorts of options can be found and, in the end, a new custom <span class="hlt">design</span> is used in most of the cases. Even though this might be interesting in some specific cases, for most of them it would be more convenient to have a straightforward system based on standard components. One of the options to achieve this is to <span class="hlt">design</span> the secondary power system with an Intermediate Bus Converter (<span class="hlt">IBC</span>) and Point of Load converters (POLs). This paper presents a study of this architecture and some experimental verifications to establish some basic rules devoted to achieve an optimum <span class="hlt">design</span> of this system.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li class="active"><span>22</span></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_22 --> <div id="page_23" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li class="active"><span>23</span></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="441"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2835143','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2835143"><span>Transcriptional Enhancers Induce Insertional Gene Deregulation Independently From the Vector <span class="hlt">Type</span> and <span class="hlt">Design</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Maruggi, Giulietta; Porcellini, Simona; Facchini, Giulia; Perna, Serena K; Cattoglio, Claudia; Sartori, Daniela; Ambrosi, Alessandro; Schambach, Axel; Baum, Christopher; Bonini, Chiara; Bovolenta, Chiara; Mavilio, Fulvio; Recchia, Alessandra</p> <p>2009-01-01</p> <p>The integration characteristics of retroviral (RV) vectors increase the probability of interfering with the regulation of cellular genes, and account for a tangible risk of insertional mutagenesis in treated patients. To assess the potential genotoxic risk of conventional or self-inactivating (SIN) γ-RV and lentiviral (LV) vectors independently from the biological consequences of the insertion event, we developed a quantitative assay based on real-time reverse transcriptase—PCR on low-density arrays to evaluate alterations of gene expression in individual primary T-cell clones. We show that the Moloney leukemia virus long terminal repeat (LTR) enhancer has the strongest activity in both a γ-RV and a LV vector context, while an internal cellular promoter induces deregulation of gene expression less frequently, at a shorter range and to a lower extent in both vector <span class="hlt">types</span>. Downregulation of gene expression was observed only in the context of LV vectors. This study indicates that insertional gene activation is determined by the characteristics of the transcriptional regulatory elements carried by the vector, and is largely independent from the vector <span class="hlt">type</span> or <span class="hlt">design</span>. PMID:19293778</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29201589','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29201589"><span><span class="hlt">Designing</span> an ICT self-management service: suggestions from persons with <span class="hlt">type</span> 2 diabetes.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Gardsten, Cecilia; Mörtberg, Christina; Blomqvist, Kerstin</p> <p>2017-01-01</p> <p>This paper reports the wishes and needs of people with <span class="hlt">type</span> 2 diabetes (T2DM) for a future information and communication technology (ICT) self-management service to help manage their condition and their everyday life. Diabetes is a chronic disease affecting more and more people and placing increasing demands on health care. The self-management of diabetes includes instrumental and, decision-making skills and skills in managing daily activities, which may be supported by an ICT service. In this study we used a participatory <span class="hlt">design</span> including two sessions of Future Workshop (FW) as part of a larger research project on the self-management of diabetes. Adults with <span class="hlt">type</span> 2 diabetes participated in two FW sessions in which their expressed wishes and needs for an ICT service all fell under the broad category of Acceptance of the diagnosis, with three other suggestions; Trust in partnerships, Communication, and Individualized information. The participants' experience of the FW as a democratic process and their appreciation of mutual learning contributed to these results, which are consistent with the aims of person-centred care.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3799540','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3799540"><span><span class="hlt">Design</span> of an mHealth App for the Self-management of Adolescent <span class="hlt">Type</span> 1 Diabetes: A Pilot Study</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Casselman, Mark; Hamming, Nathaniel; Katzman, Debra K; Palmert, Mark R</p> <p>2012-01-01</p> <p>Background The use of mHealth apps has shown improved health outcomes in adult populations with <span class="hlt">type</span> 2 diabetes mellitus. However, this has not been shown in the adolescent <span class="hlt">type</span> 1 population, despite their predisposition to the use of technology. We hypothesized that a more tailored approach and a strong adherence mechanism is needed for this group. Objective To <span class="hlt">design</span>, develop, and pilot an mHealth intervention for the management of <span class="hlt">type</span> 1 diabetes in adolescents. Methods We interviewed adolescents with <span class="hlt">type</span> 1 diabetes and their family caregivers. <span class="hlt">Design</span> principles were derived from a thematic analysis of the interviews. User-centered <span class="hlt">design</span> was then used to develop the mobile app bant. In the 12-week evaluation phase, a pilot group of 20 adolescents aged 12–16 years, with a glycated hemoglobin (HbA1c) of between 8% and 10% was sampled. Each participant was supplied with the bant app running on an iPhone or iPod Touch and a LifeScan glucometer with a Bluetooth adapter for automated transfers to the app. The outcome measure was the average daily frequency of blood glucose measurement during the pilot compared with the preceding 12 weeks. Results Thematic analysis findings were the role of data collecting rather than decision making; the need for fast, discrete transactions; overcoming decision inertia; and the need for ad hoc information sharing. <span class="hlt">Design</span> aspects of the resultant app emerged through the user-centered <span class="hlt">design</span> process, including simple, automated transfer of glucometer readings; the use of a social community; and the concept of gamification, whereby routine behaviors and actions are rewarded in the form of iTunes music and apps. Blood glucose trend analysis was provided with immediate prompting of the participant to suggest both the cause and remedy of the adverse trend. The pilot evaluation showed that the daily average frequency of blood glucose measurement increased 50% (from 2.4 to 3.6 per day, P = .006, n = 12). A total of 161 rewards (average of</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/17579673','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/17579673"><span><span class="hlt">Design</span> of transmission-<span class="hlt">type</span> phase holograms for a compact radar-cross-section measurement range at 650 GHz.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Noponen, Eero; Tamminen, Aleksi; Vaaja, Matti</p> <p>2007-07-10</p> <p>A <span class="hlt">design</span> formalism is presented for transmission-<span class="hlt">type</span> phase holograms for use in a submillimeter-wave compact radar-cross-section (RCS) measurement range. The <span class="hlt">design</span> method is based on rigorous electromagnetic grating theory combined with conventional hologram synthesis. Hologram structures consisting of a curved groove pattern on a 320 mmx280 mm Teflon plate are <span class="hlt">designed</span> to transform an incoming spherical wave at 650 GHz into an output wave generating a 100 mm diameter planar field region (quiet zone) at a distance of 1 m. The reconstructed quiet-zone field is evaluated by a numerical simulation method. The uniformity of the quiet-zone field is further improved by reoptimizing the goal field. Measurement results are given for a test hologram fabricated on Teflon.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29445252','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29445252"><span>Implications of Measurement Assay <span class="hlt">Type</span> in <span class="hlt">Design</span> of HIV Experiments.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Cannon, LaMont; Jagarapu, Aditya; Vargas-Garcia, Cesar A; Piovoso, Michael J; Zurakowski, Ryan</p> <p>2017-12-01</p> <p>Time series measurements of circular viral episome (2-LTR) concentrations enable indirect quantification of persistent low-level Human Immunodeficiency Virus (HIV) replication in patients on Integrase-Inhibitor intensified Combined Antiretroviral Therapy (cART). In order to determine the magnitude of these low level infection events, blood has to be drawn from a patients at a frequency and volume that is strictly regulated by the Institutional Review Board (IRB). Once the blood is drawn, the 2-LTR concentration is determined by quantifying the amount of HIV DNA present in the sample via a PCR (Polymerase Chain Reaction) assay. Real time quantitative Polymerase Chain Reaction (qPCR) is a widely used method of performing PCR; however, a newer droplet digital Polymerase Chain Reaction (ddPCR) method has been shown to provide more accurate quantification of DNA. Using a validated model of HIV viral replication, this paper demonstrates the importance of considering DNA quantification assay <span class="hlt">type</span> when optimizing experiment <span class="hlt">design</span> conditions. Experiments are optimized using a Genetic Algorithm (GA) to locate a family of suboptimal sample schedules which yield the highest fitness. Fitness is defined as the expected information gained in the experiment, measured by the Kullback-Leibler Divergence (KLD) between the prior and posterior distributions of the model parameters. We compare the information content of the optimized schedules to uniform schedules as well as two clinical schedules implemented by researchers at UCSF and the University of Melbourne. This work shows that there is a significantly greater gain information in experiments using a ddPCR assay vs. a qPCR assay and that certain experiment <span class="hlt">design</span> considerations should be taken when using either assay.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23660083','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23660083"><span><span class="hlt">Designing</span> for <span class="hlt">designers</span>: insights into the knowledge users of inclusive <span class="hlt">design</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Dong, Hua; McGinley, Chris; Nickpour, Farnaz; Cifter, Abdusselam Selami</p> <p>2015-01-01</p> <p>Over the last twenty years, research on inclusive <span class="hlt">design</span> has delivered a wealth of publications and initiatives, forming an emerging knowledge base for inclusive <span class="hlt">design</span>. The inclusive <span class="hlt">design</span> knowledge base breaks down into two discrete areas - understanding end users from many different perspectives, and understanding the information needs of the knowledge users (e.g. <span class="hlt">designers</span>) who are involved in promoting and delivering inclusive <span class="hlt">design</span> solutions. Much research has focused on the end users, but in recent years, understanding the needs and the characteristics of knowledge users has added a new dimension to the research task. This paper focuses on the knowledge users of inclusive <span class="hlt">design</span>. It discusses the different <span class="hlt">types</span> of knowledge users and their knowledge needs. The research programmes undertaken by the Inclusive <span class="hlt">Design</span> Research Group (IDRG) are used to illustrate the process of understanding knowledge needs of <span class="hlt">designers</span>, developing different <span class="hlt">types</span> of tools to meet those needs and evaluating their effectiveness. The paper concludes with a discussion on how to adopt an inclusive <span class="hlt">design</span> research methodology to effectively engage the knowledge users in the development of inclusive <span class="hlt">design</span> tools. Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://images.nasa.gov/#/details-6762211.html','SCIGOVIMAGE-NASA'); return false;" href="https://images.nasa.gov/#/details-6762211.html"><span>n/a</span></a></p> <p><a target="_blank" href="https://images.nasa.gov/">NASA Image and Video Library</a></p> <p></p> <p>1967-11-01</p> <p>Workmen at the Kennedy Space Center position the nose cone for the 204LM-1, an unmanned Apollo mission that tested the Apollo Lunar Module (LM) in Earth orbit. Also known as Apollo 5, the spacecraft was launched on the fourth Saturn <span class="hlt">IBC</span> launch vehicle. Developed by the Marshall Space Flight Center (MSFC) as an interim vehicle in MSFC's "building block" approach to the Saturn rocket development, the Saturn <span class="hlt">IBC</span> utilized Saturn I technology to further develop and refine a larger booster and the Apollo spacecraft capabilities required for the manned lunar missions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24339168','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24339168"><span>Biomarker discovery study <span class="hlt">design</span> for <span class="hlt">type</span> 1 diabetes in The Environmental Determinants of Diabetes in the Young (TEDDY) study.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lee, Hye-Seung; Burkhardt, Brant R; McLeod, Wendy; Smith, Susan; Eberhard, Chris; Lynch, Kristian; Hadley, David; Rewers, Marian; Simell, Olli; She, Jin-Xiong; Hagopian, Bill; Lernmark, Ake; Akolkar, Beena; Ziegler, Anette G; Krischer, Jeffrey P</p> <p>2014-07-01</p> <p>The Environmental Determinants of Diabetes in the Young planned biomarker discovery studies on longitudinal samples for persistent confirmed islet cell autoantibodies and <span class="hlt">type</span> 1 diabetes using dietary biomarkers, metabolomics, microbiome/viral metagenomics and gene expression. This article describes the details of planning The Environmental Determinants of Diabetes in the Young biomarker discovery studies using a nested case-control <span class="hlt">design</span> that was chosen as an alternative to the full cohort analysis. In the frame of a nested case-control <span class="hlt">design</span>, it guides the choice of matching factors, selection of controls, preparation of external quality control samples and reduction of batch effects along with proper sample allocation. Our <span class="hlt">design</span> is to reduce potential bias and retain study power while reducing the costs by limiting the numbers of samples requiring laboratory analyses. It also covers two primary end points (the occurrence of diabetes-related autoantibodies and the diagnosis of <span class="hlt">type</span> 1 diabetes). The resulting list of case-control matched samples for each laboratory was augmented with external quality control samples. Copyright © 2013 John Wiley & Sons, Ltd.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22420386-once-daily-radiation-therapy-inflammatory-breast-cancer','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22420386-once-daily-radiation-therapy-inflammatory-breast-cancer"><span>Once-Daily Radiation Therapy for Inflammatory Breast Cancer</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Brown, Lindsay; Harmsen, William; Blanchard, Miran</p> <p>2014-08-01</p> <p>Purpose: Inflammatory breast cancer (<span class="hlt">IBC</span>) is a rare and aggressive breast cancer variant treated with multimodality therapy. A variety of approaches intended to escalate the intensity and efficacy of radiation therapy have been reported, including twice-daily radiation therapy, dose escalation, and aggressive use of bolus. Herein, we examine our outcomes for patients treated with once-daily radiation therapy with aggressive bolus utilization, focusing on treatment technique. Methods and Materials: A retrospective review of patients with nonmetastatic <span class="hlt">IBC</span> treated from January 1, 2000, through December 31, 2010, was performed. Locoregional control (LRC), disease-free survival (DFS), overall survival (OS) and predictors thereof weremore » assessed. Results: Fifty-two women with <span class="hlt">IBC</span> were identified, 49 (94%) of whom were treated with neoadjuvant chemotherapy. All underwent mastectomy followed by adjuvant radiation therapy. Radiation was delivered in once-daily fractions of 1.8 to 2.25 Gy (median, 2 Gy). Patients were typically treated with daily 1-cm bolus throughout treatment, and 33 (63%) received a subsequent boost to the mastectomy scar. Five-year Kaplan Meier survival estimates for LRC, DFS, and OS were 81%, 56%, and 64%, respectively. Locoregional recurrence was associated with poorer OS (P<.001; hazard ratio [HR], 4.1). Extracapsular extension was associated with worse LRC (P=.02), DFS (P=.007), and OS (P=.002). Age greater than 50 years was associated with better DFS (P=.03). Pathologic complete response was associated with a trend toward improved LRC (P=.06). Conclusions: Once-daily radiation therapy with aggressive use of bolus for <span class="hlt">IBC</span> results in outcomes consistent with previous reports using various intensified radiation therapy regimens. LRC remains a challenge despite modern systemic therapy. Extracapsular extension, age ≤50 years, and lack of complete response to chemotherapy appear to be associated with worse outcomes. Novel strategies are</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018JHyd..560..326C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018JHyd..560..326C"><span>Impacts of correcting the inter-variable correlation of climate model outputs on hydrological modeling</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Chen, Jie; Li, Chao; Brissette, François P.; Chen, Hua; Wang, Mingna; Essou, Gilles R. C.</p> <p>2018-05-01</p> <p>Bias correction is usually implemented prior to using climate model outputs for impact studies. However, bias correction methods that are commonly used treat climate variables independently and often ignore inter-variable dependencies. The effects of ignoring such dependencies on impact studies need to be investigated. This study aims to assess the impacts of correcting the inter-variable correlation of climate model outputs on hydrological modeling. To this end, a joint bias correction (JBC) method which corrects the joint distribution of two variables as a whole is compared with an independent bias correction (<span class="hlt">IBC</span>) method; this is considered in terms of correcting simulations of precipitation and temperature from 26 climate models for hydrological modeling over 12 watersheds located in various climate regimes. The results show that the simulated precipitation and temperature are considerably biased not only in the individual distributions, but also in their correlations, which in turn result in biased hydrological simulations. In addition to reducing the biases of the individual characteristics of precipitation and temperature, the JBC method can also reduce the bias in precipitation-temperature (P-T) correlations. In terms of hydrological modeling, the JBC method performs significantly better than the <span class="hlt">IBC</span> method for 11 out of the 12 watersheds over the calibration period. For the validation period, the advantages of the JBC method are greatly reduced as the performance becomes dependent on the watershed, GCM and hydrological metric considered. For arid/tropical and snowfall-rainfall-mixed watersheds, JBC performs better than <span class="hlt">IBC</span>. For snowfall- or rainfall-dominated watersheds, however, the two methods behave similarly, with <span class="hlt">IBC</span> performing somewhat better than JBC. Overall, the results emphasize the advantages of correcting the P-T correlation when using climate model-simulated precipitation and temperature to assess the impact of climate change on watershed</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19980223953','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19980223953"><span>The <span class="hlt">Design</span> of Feedback Control Systems Containing a Saturation <span class="hlt">Type</span> Nonlinearity</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Schmidt, Stanley F.; Harper, Eleanor V.</p> <p>1960-01-01</p> <p>A derivation of the optimum response for a step input for plant transfer functions which have an unstable pole and further data on plants with a single zero in the left half of the s plane. The calculated data are presented tabulated in normalized form. Optimum control systems are considered. The optimum system is defined as one which keeps the error as small as possible regardless of the input, under the constraint that the input to the plant (or controlled system) is limited. Intuitive arguments show that in the case where only the error can be sensed directly, the optimum system is obtained from the optimum relay or on-off solution. References to known solutions are presented. For the case when the system is of the sampled-data <span class="hlt">type</span>, arguments are presented which indicate the optimum sampled-data system may be extremely difficult if not impossible to realize practically except for very simple plant transfer functions. Two examples of aircraft attitude autopilots are presented, one for a statically stable and the other for a statically unstable airframe. The rate of change of elevator motion is assumed limited for these examples. It is shown that by use of nonlinear <span class="hlt">design</span> techniques described in NASA TN D-20 one can obtain near optimum response for step inputs and reason- able response to sine wave inputs for either case. Also, the nonlinear <span class="hlt">design</span> prevents inputs from driving the system unstable for either case.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018JCAP...01..025S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018JCAP...01..025S"><span>Constraining high-energy neutrino emission from choked jets in stripped-envelope supernovae</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Senno, Nicholas; Murase, Kohta; Mészáros, Peter</p> <p>2018-01-01</p> <p>There are indications that γ-ray dark objects such as supernovae (SNe) with choked jets, and the cores of active galactic nuclei may contribute to the diffuse flux of astrophysical neutrinos measured by the IceCube observatory. In particular, stripped-envelope SNe have received much attention since they are capable of producing relativistic jets and could explain the diversity in observations of collapsar explosions (e.g., gamma-ray bursts (GRBs), low-luminosity GRBs, and <span class="hlt">Type</span> <span class="hlt">Ibc</span> SNe). We use an unbinned maximum likelihood method to search for spatial and temporal coincidences between <span class="hlt">Type</span> <span class="hlt">Ibc</span> core-collapse SNe, which may harbor a choked jet, and muon neutrinos from a sample of IceCube up-going track-like events measured from May 2011–May 2012. In this stacking analysis, we find no significant deviation from a background-only hypothesis using one year of data, and are able to place upper limits on the total amount of isotropic equivalent energy that choked jet core-collapse SNe deposit in cosmic rays Script Ecr and the fraction of core-collapse SNe which have a jet pointed towards Earth fjet. This analysis can be extended with yet to be made public IceCube data, and the increased amount of optically detected core-collapse SNe discovered by wide field-of-view surveys such as the Palomar Transient Factory and All-Sky Automated Survey for Supernovae. The choked jet SNe/high-energy cosmic neutrino connection can be more tightly constrained in the near future.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27310823','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27310823"><span><span class="hlt">Designing</span> peptide inhibitor of insulin receptor to induce diabetes mellitus <span class="hlt">type</span> 2 in animal model Mus musculus.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Permatasari, Galuh W; Utomo, Didik H; Widodo</p> <p>2016-10-01</p> <p>A <span class="hlt">designing</span> peptide as agent for inducing diabetes mellitus <span class="hlt">type</span> 2 (T2DM) in an animal model is challenging. The computational approach provides a sophisticated tool to <span class="hlt">design</span> a functional peptide that may block the insulin receptor activity. The peptide that able to inhibit the binding between insulin and insulin receptor is a warrant for inducing T2DM. Therefore, we <span class="hlt">designed</span> a potential peptide inhibitor of insulin receptor as an agent to generate T2DM animal model by bioinformatics approach. The peptide has been developed based on the structure of insulin receptor binding site of insulin and then modified it to obtain the best properties of half life, hydrophobicity, antigenicity, and stability binding into insulin receptor. The results showed that the modified peptide has characteristics 100h half-life, high-affinity -95.1±20, and high stability 28.17 in complex with the insulin receptor. Moreover, the modified peptide has molecular weight 4420.8g/Mol and has no antigenic regions. Based on the molecular dynamic simulation, the complex of modified peptide-insulin receptor is more stable than the commercial insulin receptor blocker. This study suggested that the modified peptide has the promising performance to block the insulin receptor activity that potentially induce diabetes mellitus <span class="hlt">type</span> 2 in mice. Copyright © 2016 Elsevier Ltd. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017MS%26E..269a2040L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017MS%26E..269a2040L"><span>A New <span class="hlt">Type</span> of Tea Baking Machine Based on Pro/E <span class="hlt">Design</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Lin, Xin-Ying; Wang, Wei</p> <p>2017-11-01</p> <p>In this paper, the production process of wulong tea was discussed, mainly the effect of baking on the quality of tea. The suitable baking temperature of different tea was introduced. Based on Pro/E, a new <span class="hlt">type</span> of baking machine suitable for wulong tea baking was <span class="hlt">designed</span>. The working principle, mechanical structure and constant temperature timing intelligent control system of baking machine were expounded. Finally, the characteristics and innovation of new baking machine were discussed.The mechanical structure of this baking machine is more simple and reasonable, and can use the heat of the inlet and outlet, more energy saving and environmental protection. The temperature control part adopts fuzzy PID control, which can improve the accuracy and response speed of temperature control and reduce the dependence of baking operation on skilled experience.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28372800','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28372800"><span>A novel interval <span class="hlt">type</span>-2 fractional order fuzzy PID controller: <span class="hlt">Design</span>, performance evaluation, and its optimal time domain tuning.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kumar, Anupam; Kumar, Vijay</p> <p>2017-05-01</p> <p>In this paper, a novel concept of an interval <span class="hlt">type</span>-2 fractional order fuzzy PID (IT2FO-FPID) controller, which requires fractional order integrator and fractional order differentiator, is proposed. The incorporation of Takagi-Sugeno-Kang (TSK) <span class="hlt">type</span> interval <span class="hlt">type</span>-2 fuzzy logic controller (IT2FLC) with fractional controller of PID-<span class="hlt">type</span> is investigated for time response measure due to both unit step response and unit load disturbance. The resulting IT2FO-FPID controller is examined on different delayed linear and nonlinear benchmark plants followed by robustness analysis. In order to <span class="hlt">design</span> this controller, fractional order integrator-differentiator operators are considered as <span class="hlt">design</span> variables including input-output scaling factors. A new hybridized algorithm named as artificial bee colony-genetic algorithm (ABC-GA) is used to optimize the parameters of the controller while minimizing weighted sum of integral of time absolute error (ITAE) and integral of square of control output (ISCO). To assess the comparative performance of the IT2FO-FPID, authors compared it against existing controllers, i.e., interval <span class="hlt">type</span>-2 fuzzy PID (IT2-FPID), <span class="hlt">type</span>-1 fractional order fuzzy PID (T1FO-FPID), <span class="hlt">type</span>-1 fuzzy PID (T1-FPID), and conventional PID controllers. Furthermore, to show the effectiveness of the proposed controller, the perturbed processes along with the larger dead time are tested. Moreover, the proposed controllers are also implemented on multi input multi output (MIMO), coupled, and highly complex nonlinear two-link robot manipulator system in presence of un-modeled dynamics. Finally, the simulation results explicitly indicate that the performance of the proposed IT2FO-FPID controller is superior to its conventional counterparts in most of the cases. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/9214944','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/9214944"><span><span class="hlt">Designing</span> research: ex post facto <span class="hlt">designs</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Giuffre, M</p> <p>1997-06-01</p> <p>The research <span class="hlt">design</span> is the overall plan or structure of the study. The goal of a good research <span class="hlt">design</span> is to insure internal validity and answer the question being asked. The only clear rule in selecting a <span class="hlt">design</span> is that the question dictates the <span class="hlt">design</span>. Over the next few issues this column will cover <span class="hlt">types</span> of research <span class="hlt">designs</span> and their inherent strengths and weaknesses. This article discusses ex post facto research.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4237973','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4237973"><span>Rationale and <span class="hlt">Design</span> of the Vitamin D and <span class="hlt">Type</span> 2 Diabetes (D2d) Study: A Diabetes Prevention Trial</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Pittas, Anastassios G.; Dawson-Hughes, Bess; Rosen, Clifford J.; Ware, James H.; Knowler, William C.; Staten, Myrlene A.</p> <p>2014-01-01</p> <p>OBJECTIVE Observational studies suggest that vitamin D may lower the risk of <span class="hlt">type</span> 2 diabetes. However, data from long-term trials are lacking. The Vitamin D and <span class="hlt">Type</span> 2 Diabetes (D2d) study is a randomized clinical trial <span class="hlt">designed</span> to examine whether a causal relationship exists between vitamin D supplementation and the development of diabetes in people at high risk for <span class="hlt">type</span> 2 diabetes. RESEARCH <span class="hlt">DESIGN</span> AND METHODS D2d was <span class="hlt">designed</span> with support from a U34 planning grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The final protocol was approved by the D2d Research Group, the data and safety monitoring board, and NIDDK. Key eligibility criteria are age ≥30 years, BMI of 24 (22.5 for Asian Americans) to 42 kg/m2, increased risk for diabetes (defined as meeting two of three glycemic criteria for prediabetes established by the American Diabetes Association [fasting glucose 100–125 mg/dL (5.5–6.9 mmol/L), 2-h postload glucose after 75-g glucose load 140–199 mg/dL (7.7–11.0 mmol/L), hemoglobin A1c 5.7–6.4% (39–46 mmol/mol)]), and no hyperparathyroidism, nephrolithiasis, or hypercalcemia. D2d participants are randomized to once-daily vitamin D3 (cholecalciferol 4,000 IU) or placebo and followed for an average of 3 years. The primary end point is time to incident diabetes as assessed by laboratory criteria during the study or by adjudication if diagnosed outside of D2d. Recruitment was initiated at the end of 2013. CONCLUSIONS D2d will test whether vitamin D supplementation is safe and effective at lowering the risk of progression to diabetes in people at high risk for <span class="hlt">type</span> 2 diabetes. PMID:25205139</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014ApJ...792....7F','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014ApJ...792....7F"><span>Supernova 2010as: The Lowest-velocity Member of a Family of Flat-velocity <span class="hlt">Type</span> IIb Supernovae</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Folatelli, Gastón; Bersten, Melina C.; Kuncarayakti, Hanindyo; Olivares Estay, Felipe; Anderson, Joseph P.; Holmbo, Simon; Maeda, Keiichi; Morrell, Nidia; Nomoto, Ken'ichi; Pignata, Giuliano; Stritzinger, Maximilian; Contreras, Carlos; Förster, Francisco; Hamuy, Mario; Phillips, Mark M.; Prieto, José Luis; Valenti, Stefano; Afonso, Paulo; Altenmüller, Konrad; Elliott, Jonny; Greiner, Jochen; Updike, Adria; Haislip, Joshua B.; LaCluyze, Aaron P.; Moore, Justin P.; Reichart, Daniel E.</p> <p>2014-09-01</p> <p>We present extensive optical and near-infrared photometric and spectroscopic observations of the stripped-envelope supernova SN 2010as. Spectroscopic peculiarities such as initially weak helium features and low expansion velocities with a nearly flat evolution place this object in the small family of events previously identified as transitional <span class="hlt">Type</span> <span class="hlt">Ib/c</span> supernovae (SNe). There is ubiquitous evidence of hydrogen, albeit weak, in this family of SNe, indicating that they are in fact a peculiar kind of <span class="hlt">Type</span> IIb SNe that we name "flat-velocity <span class="hlt">Type</span> IIb. The flat-velocity evolution—which occurs at different levels between 6000 and 8000 km s-1 for different SNe—suggests the presence of a dense shell in the ejecta. Despite the spectroscopic similarities, these objects show surprisingly diverse luminosities. We discuss the possible physical or geometrical unification picture for such diversity. Using archival Hubble Space Telescope images, we associate SN 2010as with a massive cluster and derive a progenitor age of ≈6 Myr, assuming a single star-formation burst, which is compatible with a Wolf-Rayet progenitor. Our hydrodynamical modeling, on the contrary, indicates that the pre-explosion mass was relatively low, ≈4 M ⊙. The seeming contradiction between a young age and low pre-SN mass may be solved by a massive interacting binary progenitor. This paper includes data gathered with the following facilities in Chile: the 6.5 m Magellan Telescopes located at Las Campanas Observatory, the Gemini Observatory, Cerro Pachón (Gemini Program GS-2008B-Q-56), and the European Organisation for Astronomical Research in the Southern Hemisphere (ESO Programmes 076.A-0156, 078.D-0048, 080.A-0516, and 082.A-0526). We have also used data from the ESO Science Archive Facility under request number gfolatelli74580 and from the NASA/ESA Hubble Space Telescope, obtained from the Hubble Legacy Archive, which is a collaboration between the Space Telescope Science Institute (STSc</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23806002','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23806002"><span>A novel <span class="hlt">type</span> of highly effective nonionic gemini alkyl O-glucoside surfactants: a versatile strategy of <span class="hlt">design</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Liu, Songbai; Sang, Ruocheng; Hong, Shan; Cai, Yujing; Wang, Hua</p> <p>2013-07-09</p> <p>A novel <span class="hlt">type</span> of highly effective gemini alkyl glucosides has been rationally <span class="hlt">designed</span> and synthesized. The gemini surfactants have been readily prepared by glycosylation of the gemini alkyl chains that are synthesized with regioselective ring-opening of ethylene glycol epoxides by the alkyl alcohols. The new gemini alkyl glucosides exhibit significantly better surface activity than the known results. Then rheological, DLS, and TEM studies have revealed the intriguing self-assembly behavior of the novel gemini surfactants. This study has proved the effectiveness of the <span class="hlt">design</span> of gemini alkyl glucosides which is modular, extendable, and synthetically simple. The new gemini surfactants have great potential as nano carriers in drug and gene delivery.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5594268','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5594268"><span>Discriminatory validity of the Aspects of Wheelchair Mobility Test as demonstrated by a comparison of four wheelchair <span class="hlt">types</span> <span class="hlt">designed</span> for use in low-resource areas</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Hamm, Elisa; Wee, Joy</p> <p>2017-01-01</p> <p>Background Comparative effectiveness research on wheelchairs available in low-resource areas is needed to enable effective use of limited funds. Mobility on commonly encountered rolling environments is a key aspect of function. High variation in capacity among wheelchair users can mask changes in mobility because of wheelchair <span class="hlt">design</span>. A repeated measures protocol in which the participants use one <span class="hlt">type</span> of wheelchair and then another minimises the impact of individual variation. Objectives The Aspects of Wheelchair Mobility Test (AWMT) was <span class="hlt">designed</span> to be used in repeated measures studies in low-resource areas. It measures the impact of different wheelchair <span class="hlt">types</span> on physical performance in commonly encountered rolling environments and provides an opportunity for qualitative and quantitative participant response. This study sought to confirm the ability of the AWMT to discern differences in mobility because of wheelchair <span class="hlt">design</span>. Method Participants were wheelchair users at a boarding school for students with disabilities in a low-resource area. Each participant completed timed tests on measured tracks on rough and smooth surfaces, in tight spaces and over curbs. Four <span class="hlt">types</span> of wheelchairs <span class="hlt">designed</span> for use in low-resource areas were included. Results The protocol demonstrated the ability to discriminate changes in mobility of individuals because of wheelchair <span class="hlt">type</span>. Conclusion Comparative effectiveness studies with this protocol can enable beneficial change. This is illustrated by <span class="hlt">design</span> alterations by wheelchair manufacturers in response to results. PMID:28936413</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li class="active"><span>23</span></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_23 --> <div id="page_24" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li class="active"><span>24</span></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="461"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018JaJAP..57d0315T','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018JaJAP..57d0315T"><span>Evaluation of carrier collection probability in bifacial interdigitated-back-contact crystalline silicon solar cells by the internal quantum efficiency mapping method</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Tachibana, Tomihisa; Tanahashi, Katsuto; Mochizuki, Toshimitsu; Shirasawa, Katsuhiko; Takato, Hidetaka</p> <p>2018-04-01</p> <p>Bifacial interdigitated-back-contact (<span class="hlt">IBC</span>) silicon solar cells with a high bifaciality of 0.91 were fabricated. Screen printing and firing technology were used to reduce the production cost. For the first time, the relationship between the rear side structure and carrier collection probability was evaluated using internal quantum efficiency (IQE) mapping. The measurement results showed that the screen-printed electrode and back surface field (BSF) area led to low IQE. The low carrier collection probability by BSF area can be explained by electrical shading effects. Thus, it is clear that the IQE mapping system is useful to evaluate the <span class="hlt">IBC</span> cell.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25959313','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25959313"><span>Practicing universal <span class="hlt">design</span> to actual hand tool <span class="hlt">design</span> process.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lin, Kai-Chieh; Wu, Chih-Fu</p> <p>2015-09-01</p> <p>UD evaluation principles are difficult to implement in product <span class="hlt">design</span>. This study proposes a methodology for implementing UD in the <span class="hlt">design</span> process through user participation. The original UD principles and user experience are used to develop the evaluation items. Difference of product <span class="hlt">types</span> was considered. Factor analysis and Quantification theory <span class="hlt">type</span> I were used to eliminate considered inappropriate evaluation items and to examine the relationship between evaluation items and product <span class="hlt">design</span> factors. Product <span class="hlt">design</span> specifications were established for verification. The results showed that converting user evaluation into crucial <span class="hlt">design</span> verification factors by the generalized evaluation scale based on product attributes as well as the <span class="hlt">design</span> factors applications in product <span class="hlt">design</span> can improve users' UD evaluation. The <span class="hlt">design</span> process of this study is expected to contribute to user-centered UD application. Copyright © 2015 Elsevier Ltd and The Ergonomics Society. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012JAP...111gE710C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012JAP...111gE710C"><span><span class="hlt">Design</span> of a spoke-<span class="hlt">type</span> permanent-magnet motor with optimal winding configuration for electric vehicle applications</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Chen, Qian; Liu, Guohai; Gong, Wensheng; Qu, Li; Zhao, Wenxiang; Shen, Yue</p> <p>2012-04-01</p> <p>The spoke-<span class="hlt">type</span> motor has higher torque density than the conventional one resulting from its structure for concentrating flux from permanent magnets (PMs). However, this motor suffers from the serious distortion of back electromotive force (EMF). This paper proposes a cost-effective approach to <span class="hlt">design</span> a spoke-<span class="hlt">type</span> motor with lower harmonics of back-EMF for electric vehicle. The key is to superimpose the coil-EMF of one phase in such a way that the harmonics of the phase-EMF can be canceled, resulting in essentially sinusoidal waveforms. By using finite element method (FEM), an optimal coil-EMF vectors distribution for minimum harmonics of the phase-EMF is obtained and verified. In addition, the co-simulation technology is adopted to verify that the torque ripple under the optimal winding configuration can be significantly suppressed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16803729','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16803729"><span>Effect of keyswitch <span class="hlt">design</span> of desktop and notebook keyboards related to key stiffness and <span class="hlt">typing</span> force.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Bufton, Marcia J; Marklin, Richard W; Nagurka, Mark L; Simoneau, Guy G</p> <p>2006-08-15</p> <p>This study aimed to compare and analyse rubber-dome desktop, spring-column desktop and notebook keyboards in terms of key stiffness and fingertip <span class="hlt">typing</span> force. The spring-column keyboard resulted in the highest mean peak contact force (0.86N), followed by the rubber dome desktop (0.68N) and the notebook (0.59N). All these differences were statistically significant. Likewise, the spring-column keyboard registered the highest fingertip <span class="hlt">typing</span> force and the notebook keyboard the lowest. A comparison of forces showed the notebook (rubber dome) keyboard had the highest fingertip-to-peak contact force ratio (overstrike force), and the spring-column generated the least excess force (as a ratio of peak contact force). The results of this study could aid in optimizing computer key <span class="hlt">design</span> that could possibly reduce subject discomfort and fatigue.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21912823','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21912823"><span>Skin thickening as unique pathologic sign of an inflammatory breast cancer: a case report and review of the literature.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ballesio, L; D'Ambrosio, I; Ravazzolo, N; Angeletti, M; Di Pastena, F; Tardioli, S; Lodise, P; Marini, M</p> <p>2011-01-01</p> <p>We report the case of a 42-year-old woman with inflammatory cancer of the right breast treated with neoadjuvant chemotherapy, surgery, additional chemotherapy, and consolidative radiotherapy (RT), that has metastatized to the chest wall and presented a resumption of disease on the contralateral breast. Magnetic Resonance (MR), performed after the second phase's fourth round of additional chemotherapy, showed a modest reduction of scar metastases on the right and a contralateral anomalous skin thickening with high signal intensity in T2 weighted images (WI) with multiple mass-like enhancements located in a wide area of the central region at the union of higher quadrants. These findings were suggestive for resumption of contralateral disease; the biopsy confirmed an inflammatory breast cancer (<span class="hlt">IBC</span>) infiltrating lobular <span class="hlt">type</span> with high mitotic rate. A retrospective evaluation of the previous MR exam, performed 5 months before, was conducted: on the left side only a modest skin thickening was found as an early sign. A careful review of the literature has confirmed that skin thickening, increased density and clinical signs of inflammation are the most common findings in inflammatory cancer. We report the case of a patient affected by <span class="hlt">IBC</span> whose unique early sign of resumption on the contralateral breast was skin thickening.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3675774','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3675774"><span>Host-Pathogen Checkpoints and Population Bottlenecks in Persistent and Intracellular Uropathogenic E. coli Bladder Infection</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Hannan, Thomas J.; Totsika, Makrina; Mansfield, Kylie J.; Moore, Kate H.; Schembri, Mark A.; Hultgren, Scott J.</p> <p>2013-01-01</p> <p>Bladder infections affect millions of people yearly, and recurrent symptomatic infections (cystitis) are very common. The rapid increase in infections caused by multi-drug resistant uropathogens threatens to make recurrent cystitis an increasingly troubling public health concern. Uropathogenic E. coli (UPEC) cause the vast majority of bladder infections. Upon entry into the lower urinary tract, UPEC face obstacles to colonization that constitute population bottlenecks, reducing diversity and selecting for fit clones. A critical mucosal barrier to bladder infection is the epithelium (urothelium). UPEC bypass this barrier when they invade urothelial cells and form intracellular bacterial communities (<span class="hlt">IBCs</span>), a process which requires <span class="hlt">type</span> 1 pili. <span class="hlt">IBCs</span> are transient in nature, occurring primarily during acute infection. Chronic bladder infection is common and can be either latent, in the form of the Quiescent Intracellular Reservoir (QIR), or active, in the form of asymptomatic bacteriuria (ASB/ABU) or chronic cystitis. In mice, the fate of bladder infection: QIR, ASB, or chronic cystitis, is determined within the first 24 hours of infection and constitutes a putative host-pathogen mucosal checkpoint that contributes to susceptibility to recurrent cystitis. Knowledge of these checkpoints and bottlenecks is critical for our understanding of bladder infection and efforts to devise novel therapeutic strategies. PMID:22404313</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28829036','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28829036"><span>Proposal to <span class="hlt">designate</span> Methylothermus subterraneus Hirayama et al. 2011 as the <span class="hlt">type</span> species of the genus Methylothermus. Request for an Opinion.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Boden, Rich; Oren, Aharon</p> <p>2017-09-01</p> <p>Methylothermus thermalis, the <span class="hlt">designated</span> <span class="hlt">type</span> species of the genus Methylothermus, is not available from culture collections and its nomenclatural <span class="hlt">type</span> is a patent strain. According to Rule 20a of the International Code of Nomenclature of Prokaryotes, only species whose names are legitimate may serve as <span class="hlt">types</span> of genera. Therefore, the name Methylothermus and the names of the species Methylothermus thermalis and Methylothermus subterraneus are not validly published and are illegitimate. We therefore submit a Request for an Opinion to the Judicial Commission of the ICSP to consider the later-named Methylothermus subterraneus as the new <span class="hlt">type</span> species of the genus Methylothermus based on Rule 20e(2).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://rosap.ntl.bts.gov/view/dot/25321','DOTNTL'); return false;" href="https://rosap.ntl.bts.gov/view/dot/25321"><span><span class="hlt">Design</span> of spur-<span class="hlt">type</span> streambank stabilization structures.</span></a></p> <p><a target="_blank" href="http://ntlsearch.bts.gov/tris/index.do">DOT National Transportation Integrated Search</a></p> <p></p> <p>1985-07-01</p> <p>streambank stabilization structures has been conducted to establish <span class="hlt">design</span> guidelines and other criteria for the use of spurs. The recommendations and findings are based on a thorough review of pertinent literature, analysis of several hundred field ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015SPIE.9668E..3OC','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015SPIE.9668E..3OC"><span><span class="hlt">Designing</span> small molecule polyaromatic p- and n-<span class="hlt">type</span> semiconductor materials for organic electronics</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Collis, Gavin E.</p> <p>2015-12-01</p> <p>By combining computational aided <span class="hlt">design</span> with synthetic chemistry, we are able to identify core 2D polyaromatic small molecule templates with the necessary optoelectronic properties for p- and n-<span class="hlt">type</span> materials. By judicious selection of the functional groups, we can tune the physical properties of the material making them amenable to solution and vacuum deposition. In addition to solubility, we observe that the functional group can influence the thin film molecular packing. By developing structure-property relationships (SPRs) for these families of compounds we observe that some compounds are better suited for use in organic solar cells, while others, varying only slightly in structure, are favoured in organic field effect transistor devices. We also find that the processing conditions can have a dramatic impact on molecular packing (i.e. 1D vs 2D polymorphism) and charge mobility; this has implications for material and device long term stability. We have developed small molecule p- and n-<span class="hlt">type</span> materials for organic solar cells with efficiencies exceeding 2%. Subtle variations in the functional groups of these materials produces p- and ntype materials with mobilities higher than 0.3 cm2/Vs. We are also interested in using our SPR approach to develop materials for sensor and bioelectronic applications.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017E3SWC..2305003E','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017E3SWC..2305003E"><span>Optimum <span class="hlt">Design</span> Parameters of Box Window DSF Office at Different Glazing <span class="hlt">Types</span> under Sub Interval of Intermediate Sky Conditions (20-40 klux)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Elayeb, O. K.; Alghoul, M. A.; Sopian, K.; Khrita, N. G.</p> <p>2017-11-01</p> <p>Despite Double skin façade (DSF) buildings are widely deployed worldwide, daylighting strategy is not commonly incorporated in these buildings compare to other strategies. Therefore, further theoretical and experimental studies would lead to adopting daylighting strategy in DSF office buildings. The aim of this study is to investigate the daylighting performance of office building at different <span class="hlt">design</span> parameters of box window DSF using different glazing <span class="hlt">types</span> under sub interval of intermediate sky conditions (20-40) klux using the (IES VE) simulation tool from Integrated Environmental Solutions - Virtual Environment. The implemented <span class="hlt">design</span> parameters are window wall ratio (WWR) of internal façade (10-100) %, cavity depth (CD) of DSF (1-2.5) m and different glazing <span class="hlt">types</span>. The glazing <span class="hlt">types</span> were selected from the list available in the (IES VE) simulation tool. After series of evaluations, bronze tinted coating (STOPSOL) is implemented for the exterior façade while clear float, clear reflective coating (STOPSOL), grey and brown tinted coating (Anti-sun float) and blue coating tinted (SUNCOOL float) are implemented for the interior façade. In this paper, several evaluation parameters are used to quantify the optimum <span class="hlt">design</span> parameters that would balance the daylighting requirements of a box window DSF office versus sky conditions range (20-40) klux. The optimum <span class="hlt">design</span> parameters of DSF office building obtained under different glazing <span class="hlt">types</span> are highlighted as follows. When using bronze tinted coating (STOPSOL) for the exterior façade, the glazing <span class="hlt">types</span> of interior façade that showed superior daylighting performance of DSF office at (CD of 1.0m with WWR of 70%), (CD of 1.5m with WWR of 70%), (CD of 2.0m with WWR of 70%) and (CD of 2.0m with WWR of 70%) are grey tinted coating (Anti-sun float), clear reflective coating (STOPSOL), brown tinted coating (Anti-sun float), and clear float glazing respectively. Blue Coating tinted (SUNCOOL float) of interior façade glazing</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28223515','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28223515"><span>Rational <span class="hlt">design</span> of adjuvants targeting the C-<span class="hlt">type</span> lectin Mincle.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Decout, Alexiane; Silva-Gomes, Sandro; Drocourt, Daniel; Barbe, Sophie; André, Isabelle; Cueto, Francisco J; Lioux, Thierry; Sancho, David; Pérouzel, Eric; Vercellone, Alain; Prandi, Jacques; Gilleron, Martine; Tiraby, Gérard; Nigou, Jérôme</p> <p>2017-03-07</p> <p>The advances in subunit vaccines development have intensified the search for potent adjuvants, particularly adjuvants inducing cell-mediated immune responses. Identification of the C-<span class="hlt">type</span> lectin Mincle as one of the receptors underlying the remarkable immunogenicity of the mycobacterial cell wall, via recognition of trehalose-6,6'-dimycolate (TDM), has opened avenues for the rational <span class="hlt">design</span> of such molecules. Using a combination of chemical synthesis, biological evaluation, molecular dynamics simulations, and protein mutagenesis, we gained insight into the molecular bases of glycolipid recognition by Mincle. Unexpectedly, the fine structure of the fatty acids was found to play a key role in the binding of a glycolipid to the carbohydrate recognition domain of the lectin. Glucose and mannose esterified at O -6 by a synthetic α-ramified 32-carbon fatty acid showed agonist activity similar to that of TDM, despite their much simpler structure. Moreover, they were seen to stimulate proinflammatory cytokine production in primary human and murine cells in a Mincle-dependent fashion. Finally, they were found to induce strong Th1 and Th17 immune responses in vivo in immunization experiments in mice and conferred protection in a murine model of Mycobacterium tuberculosis infection. Here we describe the rational development of new molecules with powerful adjuvant properties.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2006cosp...36.1955N','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2006cosp...36.1955N"><span>A Consideration of HALO <span class="hlt">Type</span> Orbit <span class="hlt">Designation</span> and Maintaining for KUAFU-A and WSO/UV Missions</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Nianchuan, J.; Xian, S.; Jianguo, Y.; Guangli, W.; Jingsong, P.</p> <p></p> <p>In the new era of deep space exploration more and more explorations at special places or points in solar system are carried out and planned There are five equilibrium points in the Sun-Earth system and the orbits around these points have good dynamic attribute Due to this reason The areas vicinity equilibrium points have many advantages for space exploration In recent 20 years the NASA and ESA have successfully launched several spacecrafts orbiting the Sun-Earth collinear equilibrium points Following the developing steps of space and deep space exploration in China Chinese scientists and engineers are considering and suggesting two equilibrium points explorations One is named KUAFU-A mission whose craft will orbit L1 point and the scientific target is studying the evolution of space weather of solar-terrestrial area The other is WSO UV mission whose craft will orbit L2 point and the scientific target is studying the structure and evolution of galaxies This report is mainly about HALO <span class="hlt">type</span> orbit <span class="hlt">designation</span> and maintaining for these two missions Following points are included 1 Briefly reviewing the explorations at the equilibrium points launched by NASA and ESA 2 Simply introducing the exploration KUAFU-A and WSO UV 3 Discussing the <span class="hlt">designation</span> and maintaining of HALO <span class="hlt">type</span> orbits in some detail for KUAFU-A and WSO UV</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25914370','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25914370"><span>Adaptation to high throughput batch chromatography enhances multivariate screening.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Barker, Gregory A; Calzada, Joseph; Herzer, Sibylle; Rieble, Siegfried</p> <p>2015-09-01</p> <p>High throughput process development offers unique approaches to explore complex process <span class="hlt">design</span> spaces with relatively low material consumption. Batch chromatography is one technique that can be used to screen chromatographic conditions in a 96-well plate. Typical batch chromatography workflows examine variations in buffer conditions or comparison of multiple resins in a given process, as opposed to the assessment of protein loading conditions in combination with other factors. A modification to the batch chromatography paradigm is described here where experimental planning, programming, and a staggered loading approach increase the multivariate space that can be explored with a liquid handling system. The iterative batch chromatography (<span class="hlt">IBC</span>) approach is described, which treats every well in a 96-well plate as an individual experiment, wherein protein loading conditions can be varied alongside other factors such as wash and elution buffer conditions. As all of these factors are explored in the same experiment, the interactions between them are characterized and the number of follow-up confirmatory experiments is reduced. This in turn improves statistical power and throughput. Two examples of the <span class="hlt">IBC</span> method are shown and the impact of the load conditions are assessed in combination with the other factors explored. Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/15267644','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/15267644"><span>Irreducible Brillouin conditions and contracted Schrödinger equations for n-electron systems. III. Systems of noninteracting electrons.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kutzelnigg, Werner; Mukherjee, Debashis</p> <p>2004-04-22</p> <p>We analyze the structure and the solutions of the irreducible k-particle Brillouin conditions (IBCk) and the irreducible contracted Schrödinger equations (ICSEk) for an n-electron system without electron interaction. This exercise is very instructive in that it gives one both the perspective and the strategies to be followed in applying the <span class="hlt">IBC</span> and ICSE to physically realistic systems with electron interaction. The <span class="hlt">IBC</span>1 leads to a Liouville equation for the one-particle density matrix gamma1=gamma, consistent with our earlier analysis that the <span class="hlt">IBC</span>1 holds both for a pure and an ensemble state. The <span class="hlt">IBC</span>1 or the ICSE1 must be solved subject to the constraints imposed by the n-representability condition, which is particularly simple for gamma. For a closed-shell state gamma is idempotent, i.e., all natural spin orbitals (NSO's) have occupation numbers 0 or 1, and all cumulants lambdak with k> or =2 vanish. For open-shell states there are NSO's with fractional occupation number, and at the same time nonvanishing elements of lambda2, which are related to spin and symmetry coupling. It is often useful to describe an open-shell state by a totally symmetric ensemble state. If one wants to treat a one-particle perturbation by means of perturbation theory, this mainly as a run-up for the study of a two-particle perturbation, one is faced with the problem that the perturbation expansion of the Liouville equation gives information only on the nondiagonal elements (in a basis of the unperturbed states) of gamma. There are essentially three possibilities to construct the diagonal elements of gamma: (i) to consider the perturbation expansion of the characteristic polynomial of gamma, especially the idempotency for closed-shell states, (ii) to rely on the ICSE1, which (at variance with the <span class="hlt">IBC</span>1) also gives information on the diagonal elements, though not in a very efficient manner, and (iii) to formulate the perturbation theory in terms of a unitary transformation in Fock space</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23282150','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23282150"><span>Subtype-selective regulation of IP(3) receptors by thimerosal via cysteine residues within the IP(3)-binding core and suppressor domain.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Khan, Samir A; Rossi, Ana M; Riley, Andrew M; Potter, Barry V L; Taylor, Colin W</p> <p>2013-04-15</p> <p>IP(3)R (IP(3) [inositol 1,4,5-trisphosphate] receptors) and ryanodine receptors are the most widely expressed intracellular Ca(2+) channels and both are regulated by thiol reagents. In DT40 cells stably expressing single subtypes of mammalian IP(3)R, low concentrations of thimerosal (also known as thiomersal), which oxidizes thiols to form a thiomercurylethyl complex, increased the sensitivity of IP(3)-evoked Ca(2+) release via IP(3)R1 and IP(3)R2, but inhibited IP(3)R3. Activation of IP(3)R is initiated by IP(3) binding to the <span class="hlt">IBC</span> (IP(3)-binding core; residues 224-604) and proceeds via re-arrangement of an interface between the <span class="hlt">IBC</span> and SD (suppressor domain; residues 1-223). Thimerosal (100 μM) stimulated IP(3) binding to the isolated NT (N-terminal; residues 1-604) of IP(3)R1 and IP(3)R2, but not to that of IP(3)R3. Binding of a competitive antagonist (heparin) or partial agonist (dimeric-IP(3)) to NT1 was unaffected by thiomersal, suggesting that the effect of thimerosal is specifically related to IP(3)R activation. IP(3) binding to NT1 in which all cysteine residues were replaced by alanine was insensitive to thimerosal, so too were NT1 in which cysteine residues were replaced in either the SD or <span class="hlt">IBC</span>. This demonstrates that thimerosal interacts directly with cysteine in both the SD and <span class="hlt">IBC</span>. Chimaeric proteins in which the SD of the IP(3)R was replaced by the structurally related A domain of a ryanodine receptor were functional, but thimerosal inhibited both IP(3) binding to the chimaeric NT and IP(3)-evoked Ca(2+) release from the chimaeric IP(3)R. This is the first systematic analysis of the effects of a thiol reagent on each IP(3)R subtype. We conclude that thimerosal selectively sensitizes IP(3)R1 and IP(3)R2 to IP(3) by modifying cysteine residues within both the SD and <span class="hlt">IBC</span> and thereby stabilizing an active conformation of the receptor.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3610541','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3610541"><span>Subtype-selective regulation of IP3 receptors by thimerosal via cysteine residues within the IP3-binding core and suppressor domain</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Khan, Samir A.; Rossi, Ana M.; Riley, Andrew M.; Potter, Barry V. L.; Taylor, Colin W.</p> <p>2013-01-01</p> <p>IP3R (IP3 [inositol 1,4,5-trisphosphate] receptors) and ryanodine receptors are the most widely expressed intracellular Ca2+ channels and both are regulated by thiol reagents. In DT40 cells stably expressing single subtypes of mammalian IP3R, low concentrations of thimerosal (also known as thiomersal), which oxidizes thiols to form a thiomercurylethyl complex, increased the sensitivity of IP3-evoked Ca2+ release via IP3R1 and IP3R2, but inhibited IP3R3. Activation of IP3R is initiated by IP3 binding to the <span class="hlt">IBC</span> (IP3-binding core; residues 224–604) and proceeds via re-arrangement of an interface between the <span class="hlt">IBC</span> and SD (suppressor domain; residues 1–223). Thimerosal (100 μM) stimulated IP3 binding to the isolated NT (N-terminal; residues 1–604) of IP3R1 and IP3R2, but not to that of IP3R3. Binding of a competitive antagonist (heparin) or partial agonist (dimeric-IP3) to NT1 was unaffected by thiomersal, suggesting that the effect of thimerosal is specifically related to IP3R activation. IP3 binding to NT1 in which all cysteine residues were replaced by alanine was insensitive to thimerosal, so too were NT1 in which cysteine residues were replaced in either the SD or <span class="hlt">IBC</span>. This demonstrates that thimerosal interacts directly with cysteine in both the SD and <span class="hlt">IBC</span>. Chimaeric proteins in which the SD of the IP3R was replaced by the structurally related A domain of a ryanodine receptor were functional, but thimerosal inhibited both IP3 binding to the chimaeric NT and IP3-evoked Ca2+ release from the chimaeric IP3R. This is the first systematic analysis of the effects of a thiol reagent on each IP3R subtype. We conclude that thimerosal selectively sensitizes IP3R1 and IP3R2 to IP3 by modifying cysteine residues within both the SD and <span class="hlt">IBC</span> and thereby stabilizing an active conformation of the receptor. PMID:23282150</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23834853','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23834853"><span>Efficacy of cilostazol in prevention of bradycardia during carotid artery stenting.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ishii, Daizo; Satow, Tetsu; Murao, Kenichi; Nishimura, Kunihiro; Iihara, Koji</p> <p>2014-04-01</p> <p>Hypotension and bradycardia are known to occur frequently in carotid artery stenting (CAS), which may lead to postprocedural complications. The purpose of this retrospective study was to assess the efficacy of cilostazol, a phosphodiesterase 3 inhibitor, for preventing bradycardia and hypotension in the periprocedural period. The study population comprised 53 patients (54 lesions) with carotid artery stenosis who underwent CAS at our institution between 2004 and 2008. The patients were categorized by the use (group C, n = 26) or nonuse of cilostazol (group N, n = 28). The incidences of intraprocedural and postprocedural hypotension and bradycardia in each group were statistically assessed. Intraprocedural hypotension and bradycardia occurred in 9 cases (34.6%) and 4 cases (15.3%) in group C and in 5 cases (17.9%) and 15 cases (53.6%) in group N, respectively. Postprocedural hypotension and bradycardia occurred in 4 cases (15.4%) and 0 cases in group C and in 1 case (3.6%) and 3 cases (10.7%) in group N, respectively. The incidence of intraprocedural bradycardia (<span class="hlt">IBc</span>) was significantly lower in group C (P = .0035). Logistic regression analysis revealed that the use of cilostazol decreased the risk of <span class="hlt">IBc</span> 99.5% (odds ratio [OR] = .01, 95% confidence interval [CI]: 5.46 × 10(-6) to .04, P = .001) and distance from carotid bifurcation to maximum stenotic lesion was independently associated with <span class="hlt">IBc</span> (OR = .46, 95% CI: .29-.74, P = .001). Use of cilostazol was associated with a lower incidence of <span class="hlt">IBc</span>. Cilostazol may be a useful drug for the prevention of this complication. Copyright © 2014 National Stroke Association. Published by Elsevier Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/17039265','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/17039265"><span>Predicting response to primary chemotherapy: gene expression profiling of paraffin-embedded core biopsy tissue.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Mina, Lida; Soule, Sharon E; Badve, Sunil; Baehner, Fredrick L; Baker, Joffre; Cronin, Maureen; Watson, Drew; Liu, Mei-Lan; Sledge, George W; Shak, Steve; Miller, Kathy D</p> <p>2007-06-01</p> <p>Primary chemotherapy provides an ideal opportunity to correlate gene expression with response to treatment. We used paraffin-embedded core biopsies from a completed phase II trial to identify genes that correlate with response to primary chemotherapy. Patients with newly diagnosed stage II or III breast cancer were treated with sequential doxorubicin 75 mg/M2 q2 wks x 3 and docetaxel 40 mg/M2 weekly x 6; treatment order was randomly assigned. Pretreatment core biopsy samples were interrogated for genes that might correlate with pathologic complete response (pCR). In addition to the individual genes, the correlation of the Oncotype DX Recurrence Score with pCR was examined. Of 70 patients enrolled in the parent trial, core biopsies samples with sufficient RNA for gene analyses were available from 45 patients; 9 (20%) had inflammatory breast cancer (<span class="hlt">IBC</span>). Six (14%) patients achieved a pCR. Twenty-two of the 274 candidate genes assessed correlated with pCR (p < 0.05). Genes correlating with pCR could be grouped into three large clusters: angiogenesis-related genes, proliferation related genes, and invasion-related genes. Expression of estrogen receptor (ER)-related genes and Recurrence Score did not correlate with pCR. In an exploratory analysis we compared gene expression in <span class="hlt">IBC</span> to non-inflammatory breast cancer; twenty-four (9%) of the genes were differentially expressed (p < 0.05), 5 were upregulated and 19 were downregulated in <span class="hlt">IBC</span>. Gene expression analysis on core biopsy samples is feasible and identifies candidate genes that correlate with pCR to primary chemotherapy. Gene expression in <span class="hlt">IBC</span> differs significantly from noninflammatory breast cancer.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29462835','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29462835"><span>Controlling the <span class="hlt">type</span> I error rate in two-stage sequential adaptive <span class="hlt">designs</span> when testing for average bioequivalence.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Maurer, Willi; Jones, Byron; Chen, Ying</p> <p>2018-05-10</p> <p>In a 2×2 crossover trial for establishing average bioequivalence (ABE) of a generic agent and a currently marketed drug, the recommended approach to hypothesis testing is the two one-sided test (TOST) procedure, which depends, among other things, on the estimated within-subject variability. The power of this procedure, and therefore the sample size required to achieve a minimum power, depends on having a good estimate of this variability. When there is uncertainty, it is advisable to plan the <span class="hlt">design</span> in two stages, with an interim sample size reestimation after the first stage, using an interim estimate of the within-subject variability. One method and 3 variations of doing this were proposed by Potvin et al. Using simulation, the operating characteristics, including the empirical <span class="hlt">type</span> I error rate, of the 4 variations (called Methods A, B, C, and D) were assessed by Potvin et al and Methods B and C were recommended. However, none of these 4 variations formally controls the <span class="hlt">type</span> I error rate of falsely claiming ABE, even though the amount of inflation produced by Method C was considered acceptable. A major disadvantage of assessing <span class="hlt">type</span> I error rate inflation using simulation is that unless all possible scenarios for the intended <span class="hlt">design</span> and analysis are investigated, it is impossible to be sure that the <span class="hlt">type</span> I error rate is controlled. Here, we propose an alternative, principled method of sample size reestimation that is guaranteed to control the <span class="hlt">type</span> I error rate at any given significance level. This method uses a new version of the inverse-normal combination of p-values test, in conjunction with standard group sequential techniques, that is more robust to large deviations in initial assumptions regarding the variability of the pharmacokinetic endpoints. The sample size reestimation step is based on significance levels and power requirements that are conditional on the first-stage results. This necessitates a discussion and exploitation of the peculiar properties</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22784436','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22784436"><span>Brief cognitive behavioral therapy in primary care: a hybrid <span class="hlt">type</span> 2 patient-randomized effectiveness-implementation <span class="hlt">design</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Cully, Jeffrey A; Armento, Maria E A; Mott, Juliette; Nadorff, Michael R; Naik, Aanand D; Stanley, Melinda A; Sorocco, Kristen H; Kunik, Mark E; Petersen, Nancy J; Kauth, Michael R</p> <p>2012-07-11</p> <p>Despite the availability of evidence-based psychotherapies for depression and anxiety, they are underused in non-mental health specialty settings such as primary care. Hybrid effectiveness-implementation <span class="hlt">designs</span> have the potential to evaluate clinical and implementation outcomes of evidence-based psychotherapies to improve their translation into routine clinical care practices. This protocol article discusses the study methodology and implementation strategies employed in an ongoing, hybrid, <span class="hlt">type</span> 2 randomized controlled trial with two primary aims: (1) to determine whether a brief, manualized cognitive behavioral therapy administered by Veterans Affairs Primary Care Mental Health Integration program clinicians is effective in treating depression and anxiety in a sample of medically ill (chronic cardiopulmonary diseases) primary care patients and (2) to examine the acceptability, feasibility, and preliminary outcomes of a focused implementation strategy on improving adoption and fidelity of brief cognitive behavioral therapy at two Primary Care-Mental Health Integration clinics. The study uses a hybrid <span class="hlt">type</span> 2 effectiveness/implementation <span class="hlt">design</span> to simultaneously test clinical effectiveness and to collect pilot data on a multifaceted implementation strategy that includes an online training program, audit and feedback of session content, and internal and external facilitation. Additionally, the study engages the participation of an advisory council consisting of stakeholders from Primary Care-Mental Health Integration, as well as regional and national mental health leaders within the Veterans Administration. It targets recruitment of 320 participants randomized to brief cognitive behavioral therapy (n = 200) or usual care (n = 120). Both effectiveness and implementation outcomes are being assessed using mixed methods, including quantitative evaluation (e.g., intent-to-treat analyses across multiple time points) and qualitative methods (e.g., focus interviews</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li class="active"><span>24</span></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_24 --> <div id="page_25" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li class="active"><span>25</span></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="481"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19930091336','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19930091336"><span>Factors in the <span class="hlt">Design</span> of Centrifugal <span class="hlt">Type</span> Injection Valves for Oil Engines</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Joachim, W F; Beardsley, E G</p> <p>1928-01-01</p> <p>This research was undertaken in connection with a general study of the application of the fuel injection engine to aircraft. The purpose of the investigation was to determine the effect of four important factors in the <span class="hlt">design</span> of a centrifugal <span class="hlt">type</span> automatic injection valve on the penetration, general shape, and distribution of oil sprays. The general method employed was to record the development of single sprays by means of special high-speed photographic apparatus capable of taking 25 consecutive pictures of the moving spray at a rate of 4,000 per second. Investigations were made concerning the effects on spray characteristics, of the helix angle of helical grooves, the ratio of the cross-sectional area of the orifice to that of the grooves, the ratio of orifice length to diameter, and the position of the seat. Maximum spray penetration was obtained with a ratio of orifice length to diameter of about 1.5. Slightly greater penetration was obtained with the seat directly before the orifice.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28469240','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28469240"><span>Capacity of humic substances to complex with iron at different salinities in the Yangtze River estuary and East China Sea.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Yang, Rujun; Su, Han; Qu, Shenglu; Wang, Xuchen</p> <p>2017-05-03</p> <p>The iron binding capacities (<span class="hlt">IBC</span>) of fulvic acid (FA) and humic acid (HA) were determined in the salinity range from 5 to 40. The results indicated that <span class="hlt">IBC</span> decreased while salinity increased. In addition, dissolved iron (dFe), FA and HA were also determined along the Yangtze River estuary's increasing salinity gradient from 0.14 to 33. The loss rates of dFe, FA and HA in the Yangtze River estuary were up to 96%, 74%, and 67%, respectively. The decreases in dFe, FA and HA, as well as the change in <span class="hlt">IBC</span> of humic substances (HS) along the salinity gradient in the Yangtze River estuary were all well described by a first-order exponential attenuation model: y(dFe/FA/HA, S) = a 0 × exp(kS) + y 0 . These results indicate that flocculation of FA and HA along the salinity gradient resulted in removal of dFe. Furthermore, the exponential attenuation model described in this paper can be applied in the major estuaries of the world where most of the removal of dFe and HS occurs where freshwater and seawater mix.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013PhyC..494..255S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013PhyC..494..255S"><span><span class="hlt">Design</span> and comparative analysis of 10 MW class superconducting wind power generators according to different <span class="hlt">types</span> of superconducting wires</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Sung, Hae-Jin; Kim, Gyeong-Hun; Kim, Kwangmin; Park, Minwon; Yu, In-Keun; Kim, Jong-Yul</p> <p>2013-11-01</p> <p>Wind turbine concepts can be classified into the geared <span class="hlt">type</span> and the gearless <span class="hlt">type</span>. The gearless <span class="hlt">type</span> wind turbine is more attractive due to advantages of simplified drive train and increased energy yield, and higher reliability because the gearbox is omitted. In addition, this <span class="hlt">type</span> resolves the weight issue of the wind turbine with the light weight of gearbox. However, because of the low speed operation, this <span class="hlt">type</span> has disadvantage such as the large diameter and heavy weight of generator. Super-Conducting (SC) wind power generator can reduce the weight and volume of a wind power system. Properties of superconducting wire are very different from each company. This paper considers the <span class="hlt">design</span> and comparative analysis of 10 MW class SC wind power generators according to different <span class="hlt">types</span> of SC wires. Super-Conducting Synchronous Generators (SCSGs) using YBCO and Bi-2223 wires are optimized by an optimal method. The magnetic characteristics of the SCSGs are investigated using the finite elements method program. The optimized specifications of the SCSGs are discussed in detail, and the optimization processes can be used effectively to develop large scale wind power generation systems.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=dendrimer&id=EJ717327','ERIC'); return false;" href="https://eric.ed.gov/?q=dendrimer&id=EJ717327"><span><span class="hlt">Designing</span> Dendrimers to Offer Micelle-<span class="hlt">Type</span> Nanocontainers</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>King, Angela G.</p> <p>2005-01-01</p> <p>The properties of a dendrimer with hydrophobic and hydrophilic substituents on an orthogonal plane is synthesized and studied. The resulting polymer contains one of the substituents in its concave interior and the other at the convex surface and the <span class="hlt">design</span> promotes micelle-like behavior in polar solvent and inverted micelle arrangement in…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26891340','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26891340"><span>Misuse of booster cushions among children and adults in Shanghai-an observational and attitude study during buckling up.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Bohman, Katarina; Jorlöv, Sofia; Zhou, Shengqi; Zhao, Cloud; Sui, Bo; Ding, Chengkai</p> <p>2016-10-02</p> <p>Traffic crashes are one of the leading causes of fatalities among Chinese children. Booster cushion usage in China is low, and there are no studies showing how a population with limited experience handles booster cushions during buckling up. The purpose of this study was to evaluate the handling of and explore the attitudes toward booster cushions among children, parents, and grandparents in Shanghai. An observational study including a convenience sample of 254 children aged 4-12 years was conducted in 2 passenger cars at a shopping center in Shanghai. Parents, grandparents, or the children themselves buckled up the child on 2 <span class="hlt">types</span> of booster cushions, a 2-stage integrated booster cushion (<span class="hlt">IBC</span>) and an aftermarket booster cushion (BC). The test participants were observed during buckling up, first without and then with instructions. The test leaders conducted structured interviews. Ninety-eight percent of the uninstructed participants failed to buckle up without identified misuse on the aftermarket booster cushion and 31% of those uninstructed on the integrated booster cushion. The majority of misuse was severe, including placing the belt behind the arm and the lap belt routing above the guiding loops. Instruction reduced misuse to 58% (BC) and 12% (<span class="hlt">IBC</span>), respectively, and, in particular, severe misuse. Some misuse was related to limited knowledge of how to buckle up on the booster cushion, and some misuse was intentional in order to reduce discomfort. The participants, both children and adults, reported that they preferred the <span class="hlt">IBC</span> due to good comfort and convenience. Safety was reported as the main reason for adults using booster cushions in general, whereas children reported comfort as the most important motivation. Education is needed to ensure frequent and correct use of booster cushions in China and to raise safety awareness among children and adults. Furthermore, it is important that the booster cushions offer intuitively correct usage to a population with</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22332923','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22332923"><span>Rationally <span class="hlt">designed</span> small molecules targeting the RNA that causes myotonic dystrophy <span class="hlt">type</span> 1 are potently bioactive.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Childs-Disney, Jessica L; Hoskins, Jason; Rzuczek, Suzanne G; Thornton, Charles A; Disney, Matthew D</p> <p>2012-05-18</p> <p>RNA is an important drug target, but it is difficult to <span class="hlt">design</span> or discover small molecules that modulate RNA function. In the present study, we report that rationally <span class="hlt">designed</span>, modularly assembled small molecules that bind the RNA that causes myotonic dystrophy <span class="hlt">type</span> 1 (DM1) are potently bioactive in cell culture models. DM1 is caused when an expansion of r(CUG) repeats, or r(CUG)(exp), is present in the 3' untranslated region (UTR) of the dystrophia myotonica protein kinase (DMPK) mRNA. r(CUG)(exp) folds into a hairpin with regularly repeating 5'CUG/3'GUC motifs and sequesters muscleblind-like 1 protein (MBNL1). A variety of defects are associated with DM1, including (i) formation of nuclear foci, (ii) decreased translation of DMPK mRNA due to its nuclear retention, and (iii) pre-mRNA splicing defects due to inactivation of MBNL1, which controls the alternative splicing of various pre-mRNAs. Previously, modularly assembled ligands targeting r(CUG)(exp) were <span class="hlt">designed</span> using information in an RNA motif-ligand database. These studies showed that a bis-benzimidazole (H) binds the 5'CUG/3'GUC motif in r(CUG)(exp.) Therefore, we <span class="hlt">designed</span> multivalent ligands to bind simultaneously multiple copies of this motif in r(CUG)(exp). Herein, we report that the <span class="hlt">designed</span> compounds improve DM1-associated defects including improvement of translational and pre-mRNA splicing defects and the disruption of nuclear foci. These studies may establish a foundation to exploit other RNA targets in genomic sequence.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017AAS...23020701P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017AAS...23020701P"><span>Narrowband Hα Imaging of Old Hydrogen-deficient Supernovae</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Pooley, David A.; Vinko, Jozsef; Silverman, Jeffrey M.; Wheeler, J. Craig Craig; Szalai, Tamas; MacQueen, Phillip; Marion, Howie H.; Sárneczky, Krisztián</p> <p>2017-06-01</p> <p>We report results from our long-term observational survey aimed at discovering late-time interaction between the ejecta of hydrogen-deficient <span class="hlt">Type</span> I supernovae and the hydrogen-rich envelope expelled from the progenitor star several decades to centuries before explosion. The expelled envelope, moving with a velocity of ˜10-100 km/s, is expected to be caught up by the fast-moving SN ejecta several years to decades after explosion depending on the history of the mass-loss process acting in the progenitor star prior to explosion. The collision between the SN ejecta and the circumstellar envelope results in net emission in the Balmer-lines, especially in Hα. For the past three years, we have been using the Direct Imaging Auxiliary Functions Instrument (DIAFI) on the 2.7m Harlan J. Smith Telescope at McDonald Observatory to look for signs of late-time Hα emission in older <span class="hlt">Type</span> Ia/<span class="hlt">Ibc</span>/IIb SNe having hydrogen-poor ejecta, via narrow-band imaging. Continuum-subtracted Hα emission has been detected for 13 point sources: 9 SN <span class="hlt">Ibc</span>, 1 SN IIb and 3 SN Ia events. Thirty-eight SN sites were observed on at least two epochs, from which three objects (SN 1985F, SN 2005kl, SN 2012fh) showed significant temporal variation in the strength of their Hα emission in our DIAFI data. This suggests that the variable emission is probably not due to nearby HII regions, and hence is an important additional hint that ejecta-CSM interaction may take place in these systems. Moreover, we successfully detected the late-time Hα emission from the <span class="hlt">Type</span> Ib SN 2014C, which was recently discovered as a strongly interacting SN in other wavebands.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015APExp...8e1101T','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015APExp...8e1101T"><span>Simultaneous control of thermoelectric properties in p- and n-<span class="hlt">type</span> materials by electric double-layer gating: New <span class="hlt">design</span> for thermoelectric device</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Takayanagi, Ryohei; Fujii, Takenori; Asamitsu, Atsushi</p> <p>2015-05-01</p> <p>We report a novel <span class="hlt">design</span> of a thermoelectric device that can control the thermoelectric properties of p- and n-<span class="hlt">type</span> materials simultaneously by electric double-layer gating. Here, p-<span class="hlt">type</span> Cu2O and n-<span class="hlt">type</span> ZnO were used as the positive and negative electrodes of the electric double-layer capacitor structure. When a gate voltage was applied between the two electrodes, holes and electrons accumulated on the surfaces of Cu2O and ZnO, respectively. The thermopower was measured by applying a thermal gradient along the accumulated layer on the electrodes. We demonstrate here that the accumulated layers worked as a p-n pair of the thermoelectric device.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28106172','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28106172"><span>Carrageenan activates monocytes via <span class="hlt">type</span>-specific binding with interleukin-8: an implication for <span class="hlt">design</span> of immuno-active biomaterials.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Chan, Weng-I; Zhang, Guangpan; Li, Xin; Leung, Chung-Hang; Ma, Dik-Lung; Dong, Lei; Wang, Chunming</p> <p>2017-02-28</p> <p>Polymers that can activate the immune system may become useful biomaterials tools, given that the mechanisms underlying their actions are well understood. Herein, we report a novel <span class="hlt">type</span> of interaction between polymers and immune cells - in studying the influence of the three major <span class="hlt">types</span> of carrageenan (CGN) polysaccharides on monocyte behaviour in vitro, we found only the λ-<span class="hlt">type</span> induced monocyte adhesion and this action requires the presence of an adequate amount of serum. Further analyses indicated λ-CGN bound interleukin-8 (IL-8) in the serum and activated the cultured monocytes through an IL-8-dependent pathway. This is the first demonstration that a polymer, with a renowned immunostimulatory effect, activates the immune system via binding and harnessing the function of a specific cytokine in the microenvironment. This is a new mechanism underlying polymer-immunity interactions that may shed light on future <span class="hlt">design</span> and application of biomaterials tools targeting the immune system for a wide variety of therapeutic applications.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://pubs.er.usgs.gov/publication/5223837','USGSPUBS'); return false;" href="https://pubs.er.usgs.gov/publication/5223837"><span>Case 3058. Arctocephalus F. Cuvier, 1826 and Callorhinus Gray, 1859 (Mammalia, Pinnipedia): proposed conservation by the <span class="hlt">designation</span> of Phoca pusilla Schreber, [1775] as the <span class="hlt">type</span> species of Arctocephalus; and Otaria Peron, 1816 and Eumetopias Gill, 1866: proposed conservation by the <span class="hlt">designation</span> of Phoca leonina Molina, 1782 as the <span class="hlt">type</span> species of Otaria</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>Gardner, A.L.; Robbins, C.B.</p> <p>1999-01-01</p> <p>The purpose of this application is to conserve the accustomed understanding and usage of the fur seal name Arctocephalus F. Cuvier, 1826 by the <span class="hlt">designation</span> of Phoca pusilia Schreber, [1775] as the <span class="hlt">type</span> species, thus conserving also the name Callorhinus Gray, 1859. At present Phoca ursina Linnaeus, 1758 is the valid <span class="hlt">type</span> species of both Arctocephalus and Callorhinus. The name Arctocephalus relates to a genus of some seven fur seals from the southern hemisphere, while Callorhinus is used for the single species C. ursinus (Linnaeus) from the northern hemisphere. It is also proposed that the universal understanding of the names Otaria Peron, 1816 and Eumetopias Gill, 1866 should be conserved for the southern and northern sea lions respectively by <span class="hlt">designating</span> Phoca leonina Molina, 1782 (for which the valid specific name is P. byronia de Blainville, 1820) as the <span class="hlt">type</span> species of Otaria. At present Phoca jubata Schreber, [1776] is the <span class="hlt">type</span> species of Otaria and the name Otaria is a senior subjective synonym of Eumetopias. The four genera Arctocephalus, Callorhinus, Otaria and Eumetopias are all placed in the family OTARIIDAE Gray, 1825.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28925769','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28925769"><span>How to effectively <span class="hlt">design</span> and create a concept mobile application to aid in the management of <span class="hlt">type</span> 1 diabetes in adolescents.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>McCulloch, Victoria; Hope, Sarah; Loranger, Brian; Rea, Paul</p> <p>2017-07-01</p> <p>Diabetes is one of the most prevalent chronic health conditions in the world; with a range of diabetes-related mobile applications available to the public to aid in glycaemic control and self-management. Statistically, adherence to medication is extremely low in adolescents with <span class="hlt">Type</span> 1 Diabetes Mellitus (T1DM), therefore, this paper focuses on the research and <span class="hlt">design</span> of an interactive and educational concept mobile application aimed at early to mid-adolescents to aid in their understanding of T1DM. As visual elements are an essential part of the <span class="hlt">design</span>, this research outlines how visual components were <span class="hlt">designed</span> specifically for adolescents with T1DM.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26030793','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26030793"><span>Bayes factors based on robust TDT-<span class="hlt">type</span> tests for family trio <span class="hlt">design</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Yuan, Min; Pan, Xiaoqing; Yang, Yaning</p> <p>2015-06-01</p> <p>Adaptive transmission disequilibrium test (aTDT) and MAX3 test are two robust-efficient association tests for case-parent family trio data. Both tests incorporate information of common genetic models including recessive, additive and dominant models and are efficient in power and robust to genetic model specifications. The aTDT uses information of departure from Hardy-Weinberg disequilibrium to identify the potential genetic model underlying the data and then applies the corresponding TDT-<span class="hlt">type</span> test, and the MAX3 test is defined as the maximum of the absolute value of three TDT-<span class="hlt">type</span> tests under the three common genetic models. In this article, we propose three robust Bayes procedures, the aTDT based Bayes factor, MAX3 based Bayes factor and Bayes model averaging (BMA), for association analysis with case-parent trio <span class="hlt">design</span>. The asymptotic distributions of aTDT under the null and alternative hypothesis are derived in order to calculate its Bayes factor. Extensive simulations show that the Bayes factors and the p-values of the corresponding tests are generally consistent and these Bayes factors are robust to genetic model specifications, especially so when the priors on the genetic models are equal. When equal priors are used for the underlying genetic models, the Bayes factor method based on aTDT is more powerful than those based on MAX3 and Bayes model averaging. When the prior placed a small (large) probability on the true model, the Bayes factor based on aTDT (BMA) is more powerful. Analysis of a simulation data about RA from GAW15 is presented to illustrate applications of the proposed methods.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/21491633-five-year-analysis-treatment-efficacy-cosmesis-american-society-breast-surgeons-mammosite-breast-brachytherapy-registry-trial-patients-treated-accelerated-partial-breast-irradiation','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/21491633-five-year-analysis-treatment-efficacy-cosmesis-american-society-breast-surgeons-mammosite-breast-brachytherapy-registry-trial-patients-treated-accelerated-partial-breast-irradiation"><span>Five-Year Analysis of Treatment Efficacy and Cosmesis by the American Society of Breast Surgeons MammoSite Breast Brachytherapy Registry Trial in Patients Treated With Accelerated Partial Breast Irradiation</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Vicini, Frank, E-mail: fvicini@beaumont.ed; Beitsch, Peter; Quiet, Coral</p> <p>2011-03-01</p> <p>Purpose: To present 5-year data on treatment efficacy, cosmetic results, and toxicities for patients enrolled on the American Society of Breast Surgeons MammoSite breast brachytherapy registry trial. Methods and Materials: A total of 1440 patients (1449 cases) with early-stage breast cancer receiving breast-conserving therapy were treated with the MammoSite device to deliver accelerated partial-breast irradiation (APBI) (34 Gy in 3.4-Gy fractions). Of 1449 cases, 1255 (87%) had invasive breast cancer (<span class="hlt">IBC</span>) (median size, 10 mm) and 194 (13%) had ductal carcinoma in situ (DCIS) (median size, 8 mm). Median follow-up was 54 months. Results: Thirty-seven cases (2.6%) developed an ipsilateralmore » breast tumor recurrence (IBTR), for a 5-year actuarial rate of 3.80% (3.86% for <span class="hlt">IBC</span> and 3.39% for DCIS). Negative estrogen receptor status (p = 0.0011) was the only clinical, pathologic, or treatment-related variable associated with IBTR for patients with <span class="hlt">IBC</span> and young age (<50 years; p = 0.0096) and positive margin status (p = 0.0126) in those with DCIS. The percentage of breasts with good/excellent cosmetic results at 60 months (n = 371) was 90.6%. Symptomatic breast seromas were reported in 13.0% of cases, and 2.3% developed fat necrosis. A subset analysis of the first 400 consecutive cases enrolled was performed (352 with <span class="hlt">IBC</span>, 48 DCIS). With a median follow-up of 60.5 months, the 5-year actuarial rate of IBTR was 3.04%. Conclusion: Treatment efficacy, cosmesis, and toxicity 5 years after treatment with APBI using the MammoSite device are good and similar to those reported with other forms of APBI with similar follow-up.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29330719','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29330719"><span>Prognostic Value of Tumor-Infiltrating Lymphocyte Density Assessed Using a Standardized Method Based on Molecular Subtypes and Adjuvant Chemotherapy in Invasive Breast Cancer.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Jang, Nuri; Kwon, Hee Jung; Park, Min Hui; Kang, Su Hwan; Bae, Young Kyung</p> <p>2018-04-01</p> <p>This study investigated the prognostic value of tumor-infiltrating lymphocyte (TIL) density as determined by molecular subtype and receipt of adjuvant chemotherapy in invasive breast cancer (<span class="hlt">IBC</span>). Stromal TIL densities were evaluated in 1489 <span class="hlt">IBC</span> samples using recommendations proposed by the International TILs Working Group. Cases were allocated to high- and low-TIL density groups using a cutoff of 10%. Of the 1489 <span class="hlt">IBC</span> patients, 427 (28.7%) were assigned to the high-TIL group and 1062 (71.3%) to the low-TIL group. High TIL density was found to be significantly associated with large tumor size (p = 0.001), high histologic grade (p < 0.001), and high Ki-67 labeling index (p < 0.001). Triple-negative and human epidermal growth factor receptor 2 (HER2)-positive subtypes had significantly higher TIL densities than luminal A or B (HER2-negative) subtypes (p < 0.001). High TIL density was significantly associated with prolonged disease-free survival (DFS) by univariate (p < 0.001) and multivariate (p < 0.001) analyses. In the low-TIL-density group, the patients who did not receive adjuvant chemotherapy showed better DFS (p < 0.001), but no such survival difference was observed in the high-TIL group (p = 0.222). For the patients who received adjuvant anthracycline, high-TIL density was found to be an independent prognostic factor of favorable DFS in the luminal B (HER2-negative; p = 0.003), HER2-positive (p = 0.019), and triple-negative (p = 0.017) subtypes. Measurements of TIL density in routine clinical practice could give useful prognostic information for the triple-negative, HER2-positive, and luminal B (HER2-negative) <span class="hlt">IBC</span> subtypes, especially for patients administered adjuvant anthracycline.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016AGUFM.A51I0194E','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016AGUFM.A51I0194E"><span>Reproducing multi-model ensemble average with Ensemble-averaged Reconstructed Forcings (ERF) in regional climate modeling</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Erfanian, A.; Fomenko, L.; Wang, G.</p> <p>2016-12-01</p> <p>Multi-model ensemble (MME) average is considered the most reliable for simulating both present-day and future climates. It has been a primary reference for making conclusions in major coordinated studies i.e. IPCC Assessment Reports and CORDEX. The biases of individual models cancel out each other in MME average, enabling the ensemble mean to outperform individual members in simulating the mean climate. This enhancement however comes with tremendous computational cost, which is especially inhibiting for regional climate modeling as model uncertainties can originate from both RCMs and the driving GCMs. Here we propose the Ensemble-based Reconstructed Forcings (ERF) approach to regional climate modeling that achieves a similar level of bias reduction at a fraction of cost compared with the conventional MME approach. The new method constructs a single set of initial and boundary conditions (<span class="hlt">IBCs</span>) by averaging the <span class="hlt">IBCs</span> of multiple GCMs, and drives the RCM with this ensemble average of <span class="hlt">IBCs</span> to conduct a single run. Using a regional climate model (RegCM4.3.4-CLM4.5), we tested the method over West Africa for multiple combination of (up to six) GCMs. Our results indicate that the performance of the ERF method is comparable to that of the MME average in simulating the mean climate. The bias reduction seen in ERF simulations is achieved by using more realistic <span class="hlt">IBCs</span> in solving the system of equations underlying the RCM physics and dynamics. This endows the new method with a theoretical advantage in addition to reducing computational cost. The ERF output is an unaltered solution of the RCM as opposed to a climate state that might not be physically plausible due to the averaging of multiple solutions with the conventional MME approach. The ERF approach should be considered for use in major international efforts such as CORDEX. Key words: Multi-model ensemble, ensemble analysis, ERF, regional climate modeling</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23429872','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23429872"><span>Impact of study <span class="hlt">design</span> on development and evaluation of an activity-<span class="hlt">type</span> classifier.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>van Hees, Vincent T; Golubic, Rajna; Ekelund, Ulf; Brage, Søren</p> <p>2013-04-01</p> <p>Methods to classify activity <span class="hlt">types</span> are often evaluated with an experimental protocol involving prescribed physical activities under confined (laboratory) conditions, which may not reflect real-life conditions. The present study aims to evaluate how study <span class="hlt">design</span> may impact on classifier performance in real life. Twenty-eight healthy participants (21-53 yr) were asked to wear nine triaxial accelerometers while performing 58 activity <span class="hlt">types</span> selected to simulate activities in real life. For each sensor location, logistic classifiers were trained in subsets of up to 8 activities to distinguish between walking and nonwalking activities and were then evaluated in all 58 activities. Different weighting factors were used to convert the resulting confusion matrices into an estimation of the confusion matrix as would apply in the real-life setting by creating four different real-life scenarios, as well as one traditional laboratory scenario. The sensitivity of a classifier estimated with a traditional laboratory protocol is within the range of estimates derived from real-life scenarios for any body location. The specificity, however, was systematically overestimated by the traditional laboratory scenario. Walking time was systematically overestimated, except for lower back sensor data (range: 7-757%). In conclusion, classifier performance under confined conditions may not accurately reflect classifier performance in real life. Future studies that aim to evaluate activity classification methods are warranted to pay special attention to the representativeness of experimental conditions for real-life conditions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015SPIE.9359E..0LW','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015SPIE.9359E..0LW"><span>Hybrid reflection <span class="hlt">type</span> metasurface of nano-antennas <span class="hlt">designed</span> for optical needle field generation</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Wang, Shiyi; Zhan, Qiwen</p> <p>2015-03-01</p> <p>We propose a reflection <span class="hlt">type</span> metal-insulator-metal (MIM) metasurface composed of hybrid optical antennas for comprehensive spatial engineering the properties of optical fields. Its capability is illustrated with an example to create a radially polarized vectorial beam for optical needle field generation. Functioning as local quarter-wave-plates (QWP), the MIM metasurface is <span class="hlt">designed</span> to convert circularly polarized incident into local linear polarization to create an overall radial polarization with corresponding binary phases and desired normalized amplitude modulation ranged from 0.07 to 1. To obtain enough degrees of freedom, the optical-antenna layer comprises periodic arrangements of double metallic nano-bars with perpendicular placement and single nano-bars respectively for different amplitude modulation requirements. Both of the antennas enable to introduce π/2 retardation while reaching the desired modulation range both for phase and amplitude. Through adjusting the antennas' geometry and array carefully, we shift the gap-surface plasmon resonances facilitated by optical antennas to realize the manipulation of vectorial properties. <span class="hlt">Designed</span> at 1064 nm wavelength, the particularly generated vectorial light output can be further tightly focused by a high numerical aperture objective to obtain longitudinally polarized flat-top focal field. The so-called optical needle field is a promising candidate for novel applications that transcend disciplinary boundaries. The proposed metasurface establishes a new class of compact optical components based on nano-scale structures, leading to compound functions for vectorial light generation.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://pubs.er.usgs.gov/publication/70017422','USGSPUBS'); return false;" href="https://pubs.er.usgs.gov/publication/70017422"><span>Behavior of chlorine during coal pyrolysis</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>Shao, D.; Hutchinson, E.J.; Cao, H.; Pan, W.-P.; Chou, C.-L.</p> <p>1994-01-01</p> <p>The behavior of chlorine in Illinois coals during pyrolysis was evaluated by combined thermo-gravimetry-Fourier transform infrared spectroscopy-ion chromatography (TG-FTIR-IC) techniques. It was found that more than 90% of chlorine in Illinois coals (<span class="hlt">IBC</span>-103, 105, 106, and 109) was liberated as HCl gas during pyrolysis from 300 to 600??C, with the rate reaching a maximum at 440 ??C. Similarity of the HCl and NH3 release profiles during pyrolysis of <span class="hlt">IBC</span>-109 supports the hypothesis that the chlorine in coal may be associated with nitrogen and the chlorine is probably bonded to the basic nitrogen sites on the inner walls of coal micropores. ?? 1994 American Chemical Society.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title49-vol3/pdf/CFR-2011-title49-vol3-sec178-704.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title49-vol3/pdf/CFR-2011-title49-vol3-sec178-704.pdf"><span>49 CFR 178.704 - General <span class="hlt">IBC</span> standards.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-10-01</p> <p>... sift-proof and water-resistant. (b) All service equipment must be so positioned or protected as to..., without loss of hazardous materials, the internal pressure of the contents and the stresses of normal... transportation without gross distortion or failure and must be positioned so as to cause no undue stress in any...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017MS%26E..184a2056A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017MS%26E..184a2056A"><span><span class="hlt">Design</span> and fabrication of a fixed-bed batch <span class="hlt">type</span> pyrolysis reactor for pilot scale pyrolytic oil production in Bangladesh</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Aziz, Mohammad Abdul; Al-khulaidi, Rami Ali; Rashid, MM; Islam, M. R.; Rashid, MAN</p> <p>2017-03-01</p> <p>In this research, a development and performance test of a fixed-bed batch <span class="hlt">type</span> pyrolysis reactor for pilot scale pyrolysis oil production was successfully completed. The characteristics of the pyrolysis oil were compared to other experimental results. A solid horizontal condenser, a burner for furnace heating and a reactor shield were <span class="hlt">designed</span>. Due to the pilot scale pyrolytic oil production encountered numerous problems during the plant’s operation. This fixed-bed batch <span class="hlt">type</span> pyrolysis reactor method will demonstrate the energy saving concept of solid waste tire by creating energy stability. From this experiment, product yields (wt. %) for liquid or pyrolytic oil were 49%, char 38.3 % and pyrolytic gas 12.7% with an operation running time of 185 minutes.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li class="active"><span>25</span></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_25 --> <div class="footer-extlink text-muted" style="margin-bottom:1rem; text-align:center;">Some links on this page may take you to non-federal websites. 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