Ada (Trade Name) Compiler Validation Summary Report: International Business Machines Corporation. IBM Development System for the Ada Language System, Version 1.1.0, IBM 4381 under MVS.

DTIC Science & Technology

1988-05-22

TITLE (andSubtile) 5. TYPE OF REPORT & PERIOD COVERED Ada Compler Validation Summary Report: 22 May 1987 to 22 May 1988 International Business Machines...IBM Development System for the Ada Language System, Version 1.1.0, International Business Machines Corporation, Wright-Patterson AFB. IBM 4381 under...SUMMARY REPORT: International Business Machines Corporation IBM Development System f’or the Ada Language System, Version 1.1.0 IBM 4381 under MVS

Design and development of an IBM/VM menu system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cazzola, D.J.

1992-10-01

This report describes a full screen menu system developed using IBM`s Interactive System Productivity Facility (ISPF) and the REXX programming language. The software was developed for the 2800 IBM/VM Electrical Computer Aided Design (ECAD) system. The system was developed to deliver electronic drawing definitions to a corporate drawing release system. Although this report documents the status of the menu system when it was retired, the methodologies used and the requirements defined are very applicable to replacement systems.

Enhancements to the IBM version of COSMIC/NASTRAN

NASA Technical Reports Server (NTRS)

Brown, W. Keith

1989-01-01

Major improvements were made to the IBM version of COSMIC/NASTRAN by RPK Corporation under contract to IBM Corporation. These improvements will become part of COSMIC's IBM version and will be available in the second quarter of 1989. The first improvement is the inclusion of code to take advantage of IBM's new Vector Facility (VF) on its 3090 machines. The remaining improvements are modifications that will benefit all users as a result of the extended addressing capability provided by the MVS/XA operating system. These improvements include the availability of an in-memory data base that potentially eliminates the need for I/O to the PRIxx disk files. Another improvement is the elimination of multiple load modules that have to be loaded for every link switch within NASTRAN. The last improvement allows for NASTRAN to execute above the 16 mega-byte line. This improvement allows for NASTRAN to have access to 2 giga-bytes of memory for open core and the in-memory data base.

Detailed description of the Mayo/IBM PACS

NASA Astrophysics Data System (ADS)

Gehring, Dale G.; Persons, Kenneth R.; Rothman, Melvyn L.; Salutz, James R.; Morin, Richard L.

1991-07-01

The Mayo Clinic and IBM/Rochester have jointly developed a picture archiving system (PACS) for use with Mayo's MRI and Neuro-CT imaging modalities. The system was developed to replace the imaging system's vendor-supplied magnetic tape archiving capability. The system consists of seven MR imagers and nine CT scanners, each interfaced to the PACS via IBM Personal System/2(tm) (PS/2) computers, which act as gateways from the imaging modality to the PACS network. The PAC system operates on the token-ring component of Mayo's city-wide local area network. Also on the PACS network are four optical storage subsystems used for image archival, three optical subsystems used for image retrieval, an IBM Application System/400(tm) (AS/400) computer used for database management and multiple PS/2-based image display systems and their image servers.

TRUMP; transient and steady state temperature distribution. [IBM360,370; CDC7600; FORTRAN IV (95%) and BAL (5%) (IBM); FORTRAN IV (CDC)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elrod, D.C.; Turner, W.D.

TRUMP solves a general nonlinear parabolic partial differential equation describing flow in various kinds of potential fields, such as fields of temperature, pressure, or electricity and magnetism; simultaneously, it will solve two additional equations representing, in thermal problems, heat production by decomposition of two reactants having rate constants with a general Arrhenius temperature dependence. Steady-state and transient flow in one, two, or three dimensions are considered in geometrical configurations having simple or complex shapes and structures. Problem parameters may vary with spatial position, time, or primary dependent variables--temperature, pressure, or field strength. Initial conditions may vary with spatial position, andmore » among the criteria that may be specified for ending a problem are upper and lower limits on the size of the primary dependent variable, upper limits on the problem time or on the number of time-steps or on the computer time, and attainment of steady state.IBM360,370;CDC7600; FORTRAN IV (95%) and BAL (5%) (IBM); FORTRAN IV (CDC); OS/360 (IBM360), OS/370 (IBM370), SCOPE 2.1.5 (CDC7600); As dimensioned, the program requires 400K bytes of storage on an IBM370 and 145,100 (octal) words on a CDC7600.« less

Hazardous Waste Cleanup: IBM Corporation in Dayton, New Jersey

EPA Pesticide Factsheets

The IBM facility is located at 431 Ridge Road on a 66-acre parcel in a mixed residential and industrial section of Dayton, South Brunswick Township, Middlesex County, New Jersey. IBM's manufacturing plant was constructed in 1956 and used until 1985 for

IBM PC/IX operating system evaluation plan

NASA Technical Reports Server (NTRS)

Dominick, Wayne D. (Editor); Granier, Martin; Hall, Philip P.; Triantafyllopoulos, Spiros

1984-01-01

An evaluation plan for the IBM PC/IX Operating System designed for IBM PC/XT computers is discussed. The evaluation plan covers the areas of performance measurement and evaluation, software facilities available, man-machine interface considerations, networking, and the suitability of PC/IX as a development environment within the University of Southwestern Louisiana NASA PC Research and Development project. In order to compare and evaluate the PC/IX system, comparisons with other available UNIX-based systems are also included.

LLNL Partners with IBM on Brain-Like Computing Chip

DOE Office of Scientific and Technical Information (OSTI.GOV)

Van Essen, Brian

Lawrence Livermore National Laboratory (LLNL) will receive a first-of-a-kind brain-inspired supercomputing platform for deep learning developed by IBM Research. Based on a breakthrough neurosynaptic computer chip called IBM TrueNorth, the scalable platform will process the equivalent of 16 million neurons and 4 billion synapses and consume the energy equivalent of a hearing aid battery – a mere 2.5 watts of power. The brain-like, neural network design of the IBM Neuromorphic System is able to infer complex cognitive tasks such as pattern recognition and integrated sensory processing far more efficiently than conventional chips.

LLNL Partners with IBM on Brain-Like Computing Chip

ScienceCinema

Van Essen, Brian

2018-06-25

Lawrence Livermore National Laboratory (LLNL) will receive a first-of-a-kind brain-inspired supercomputing platform for deep learning developed by IBM Research. Based on a breakthrough neurosynaptic computer chip called IBM TrueNorth, the scalable platform will process the equivalent of 16 million neurons and 4 billion synapses and consume the energy equivalent of a hearing aid battery – a mere 2.5 watts of power. The brain-like, neural network design of the IBM Neuromorphic System is able to infer complex cognitive tasks such as pattern recognition and integrated sensory processing far more efficiently than conventional chips.

Implementation of NASTRAN on the IBM/370 CMS operating system

NASA Technical Reports Server (NTRS)

Britten, S. S.; Schumacker, B.

1980-01-01

The NASA Structural Analysis (NASTRAN) computer program is operational on the IBM 360/370 series computers. While execution of NASTRAN has been described and implemented under the virtual storage operating systems of the IBM 370 models, the IBM 370/168 computer can also operate in a time-sharing mode under the virtual machine operating system using the Conversational Monitor System (CMS) subset. The changes required to make NASTRAN operational under the CMS operating system are described.

IBM NJE protocol emulator for VAX/VMS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Engert, D.E.

1981-01-01

Communications software has been written at Argonne National Laboratory to enable a VAX/VMS system to participate as an end-node in a standard IBM network by emulating the Network Job Entry (NJE) protocol. NJE is actually a collection of programs that support job networking for the operating systems used on most large IBM-compatible computers (e.g., VM/370, MVS with JES2 or JES3, SVS, MVT with ASP or HASP). Files received by the VAX can be printed or saved in user-selected disk files. Files sent to the network can be routed to any node in the network for printing, punching, or job submission,more » as well as to a VM/370 user's virtual reader. Files sent from the VAX are queued and transmitted asynchronously to allow users to perform other work while files are awaiting transmission. No changes are required to the IBM software.« less

IBM, Elsevier Science, and academic freedom.

PubMed

Bailar, John C; Cicolella, Andre; Harrison, Robert; LaDou, Joseph; Levy, Barry S; Rohm, Timothy; Teitelbaum, Daniel T; Wang, Yung-Der; Watterson, Andrew; Yoshida, Fumikazu

2007-01-01

Elsevier Science refused to publish a study of IBM workers that IBM sought to keep from public view. Occupational and environmental health (OEH) suffers from the absence of a level playing field on which science can thrive. Industry pays for a substantial portion of OEH research. Studies done by private consulting firms or academic institutions may be published if the results suit the sponsoring companies, or they may be censored. OEH journals often reflect the dominance of industry influence on research in the papers they publish, sometimes withdrawing or modifying papers in line with industry and advertising agendas. Although such practices are widely recognized, no fundamental change is supported by government and industry or by professional organizations.

Hazardous Waste Cleanup: IBM Corporation, Former in Owego, New York

EPA Pesticide Factsheets

The corrective action activities at the facility are conducted by IBM Corporation, therefore IBM is listed as the operator of the Part 373 Hazardous Waste Management (HWM) Permit for corrective action. Lockheed Martin Corporation owns the facility and is l

Data Discovery with IBM Watson

NASA Astrophysics Data System (ADS)

Fessler, J.

2016-12-01

BM Watson is a cognitive computing system that uses machine learning, statistical analysis, and natural language processing to find and understand the clues in questions posed to it. Watson was made famous when it bested two champions on TV's Jeopardy! show. Since then, Watson has evolved into a platform of cognitive services that can be trained on very granular fields up study. Watson is being used to support a number of subject domains, such as cancer research, public safety, engineering, and the intelligence community. IBM will be providing a presentation and demonstration on the Watson technology and will discuss its capabilities including Natural Language Processing, text analytics and enterprise search, as well as cognitive computing with deep Q&A. The team will also be giving examples of how IBM Watson technology is being used to support real-world problems across a number of public sector agencies

New Generation General Purpose Computer (GPC) compact IBM unit

NASA Technical Reports Server (NTRS)

1991-01-01

New Generation General Purpose Computer (GPC) compact IBM unit replaces a two-unit earlier generation computer. The new IBM unit is documented in table top views alone (S91-26867, S91-26868), with the onboard equipment it supports including the flight deck CRT screen and keypad (S91-26866), and next to the two earlier versions it replaces (S91-26869).

Microscopic derivation of IBM and structural evolution in nuclei

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nomura, Kosuke

A Hamiltonian of the interacting boson model (IBM) is derived based on the mean-field calculations with nuclear energy density functionals (EDFs). The multi-nucleon dynamics of the surface deformation is simulated in terms of the boson degrees of freedom. The interaction strengths of the IBM Hamiltonian are determined by mapping the potential energy surfaces (PESs) of a given EDF with quadrupole degrees of freedom onto the corresponding PES of IBM. A fermion-to-boson mapping for a rotational nucleus is discussed in terms of the rotational response, which reflects a specific time-dependent feature. Ground-state correlation energy is evaluated as a signature of structuralmore » evolution. Some examples resulting from the present spectroscopic calculations are shown for neutron-rich Pt, Os and W isotopes including exotic ones.« less

Applications Performance Under MPL and MPI on NAS IBM SP2

NASA Technical Reports Server (NTRS)

Saini, Subhash; Simon, Horst D.; Lasinski, T. A. (Technical Monitor)

1994-01-01

On July 5, 1994, an IBM Scalable POWER parallel System (IBM SP2) with 64 nodes, was installed at the Numerical Aerodynamic Simulation (NAS) Facility Each node of NAS IBM SP2 is a "wide node" consisting of a RISC 6000/590 workstation module with a clock of 66.5 MHz which can perform four floating point operations per clock with a peak performance of 266 Mflop/s. By the end of 1994, 64 nodes of IBM SP2 will be upgraded to 160 nodes with a peak performance of 42.5 Gflop/s. An overview of the IBM SP2 hardware is presented. The basic understanding of architectural details of RS 6000/590 will help application scientists the porting, optimizing, and tuning of codes from other machines such as the CRAY C90 and the Paragon to the NAS SP2. Optimization techniques such as quad-word loading, effective utilization of two floating point units, and data cache optimization of RS 6000/590 is illustrated, with examples giving performance gains at each optimization step. The conversion of codes using Intel's message passing library NX to codes using native Message Passing Library (MPL) and the Message Passing Interface (NMI) library available on the IBM SP2 is illustrated. In particular, we will present the performance of Fast Fourier Transform (FFT) kernel from NAS Parallel Benchmarks (NPB) under MPL and MPI. We have also optimized some of Fortran BLAS 2 and BLAS 3 routines, e.g., the optimized Fortran DAXPY runs at 175 Mflop/s and optimized Fortran DGEMM runs at 230 Mflop/s per node. The performance of the NPB (Class B) on the IBM SP2 is compared with the CRAY C90, Intel Paragon, TMC CM-5E, and the CRAY T3D.

Training in the Workplace: An IBM Case Study. Contractor Report.

ERIC Educational Resources Information Center

Grubb, Ralph E.

International Business Machines Corporation's (IBM) efforts to develop a corporate culture are associated with its founder, Thomas J. Watson, Sr. From the start of his association with the company in 1914, the importance of education was stressed. The expansion of the education and training organization paralleled IBM's 75-year growth. In January…

Ada Compiler Validation Summary Report: Certificate Number: 880318W1. 09041, International Business Machines Corporation, IBM Development System for the Ada Language, Version 2.1.0, IBM 4381 under VM/HPO, Host and Target

DTIC Science & Technology

1988-03-28

International Business Machines Corporation IBM Development System for the Ada Language, Version 2.1.0 IBM 4381 under VM/HPO, host and target DTIC...necessary and identify by block number) International Business Machines Corporation, IBM Development System for the Ada Language, Version 2.1.0, IBM...in the compiler listed in this declaration. I declare that International Business Machines Corporation is the owner of record of the object code of the

Design and development of an IBM/VM menu system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cazzola, D.J.

1992-10-01

This report describes a full screen menu system developed using IBM's Interactive System Productivity Facility (ISPF) and the REXX programming language. The software was developed for the 2800 IBM/VM Electrical Computer Aided Design (ECAD) system. The system was developed to deliver electronic drawing definitions to a corporate drawing release system. Although this report documents the status of the menu system when it was retired, the methodologies used and the requirements defined are very applicable to replacement systems.

A DNA sequence analysis package for the IBM personal computer.

PubMed Central

Lagrimini, L M; Brentano, S T; Donelson, J E

1984-01-01

We present here a collection of DNA sequence analysis programs, called "PC Sequence" (PCS), which are designed to run on the IBM Personal Computer (PC). These programs are written in IBM PC compiled BASIC and take full advantage of the IBM PC's speed, error handling, and graphics capabilities. For a modest initial expense in hardware any laboratory can use these programs to quickly perform computer analysis on DNA sequences. They are written with the novice user in mind and require very little training or previous experience with computers. Also provided are a text editing program for creating and modifying DNA sequence files and a communications program which enables the PC to communicate with and collect information from mainframe computers and DNA sequence databases. PMID:6546433

External audio for IBM-compatible computers

NASA Technical Reports Server (NTRS)

Washburn, David A.

1992-01-01

Numerous applications benefit from the presentation of computer-generated auditory stimuli at points discontiguous with the computer itself. Modification of an IBM-compatible computer for use of an external speaker is relatively easy but not intuitive. This modification is briefly described.

Issues Identified During September 2016 IBM OpenMP 4.5 Hackathon

DOE Office of Scientific and Technical Information (OSTI.GOV)

Richards, David F.

In September, 2016 IBM hosted an OpenMP 4.5 Hackathon at the TJ Watson Research Center. Teams from LLNL, ORNL, SNL, LANL, and LBNL attended the event. As with the 2015 hackathon, IBM produced an extremely useful and successful event with unmatched support from compiler team, applications staff, and facilities. Approximately 24 IBM staff supported 4-day hackathon and spent significant time 4-6 weeks out to prepare environment and become familiar with apps. This hackathon was also the first event to feature LLVM & XL C/C++ and Fortran compilers. This report records many of the issues encountered by the LLNL teams duringmore » the hackathon.« less

Ada Compiler Validation Summary Report: Certificate Number 89020W1. 10073: International Business Machines Corporation, IBM Development System for the Ada Language, VM/CMS Ada Compiler, Version 2.1.1, IBM 3083 (Host and Target)

DTIC Science & Technology

1989-04-20

International Business Machines Corporation) IBM Development System for the Ada Language, VN11/CMS Ada Compiler, Version 2.1.1, Wright-Patterson AFB, IBM 3083...890420W1.10073 International Business Machines Corporation IBM Development System for the Ada Language VM/CMS Ada Compiler Version 2.1.1 IBM 3083... International Business Machines Corporation and reviewed by the validation team. The compiler was tested using all default option settings except for the

Making IBM's Computer, Watson, Human

ERIC Educational Resources Information Center

Rachlin, Howard

2012-01-01

This essay uses the recent victory of an IBM computer (Watson) in the TV game, "Jeopardy," to speculate on the abilities Watson would need, in addition to those it has, to be human. The essay's basic premise is that to be human is to behave as humans behave and to function in society as humans function. Alternatives to this premise are considered…

Performance Support Case Studies from IBM.

ERIC Educational Resources Information Center

Duke-Moran, Celia; Swope, Ginger; Morariu, Janis; deKam, Peter

1999-01-01

Presents two case studies that show how IBM addressed performance support solutions and electronic learning. The first developed a performance support and expert coaching solution; the second applied performance support to reducing implementation time and total cost of ownership of enterprise resource planning systems. (Author/LRW)

The IBM PC at NASA Ames

NASA Technical Reports Server (NTRS)

Peredo, James P.

1988-01-01

Like many large companies, Ames relies very much on its computing power to get work done. And, like many other large companies, finding the IBM PC a reliable tool, Ames uses it for many of the same types of functions as other companies. Presentation and clarification needs demand much of graphics packages. Programming and text editing needs require simpler, more-powerful packages. The storage space needed by NASA's scientists and users for the monumental amounts of data that Ames needs to keep demand the best database packages that are large and easy to use. Availability to the Micom Switching Network combines the powers of the IBM PC with the capabilities of other computers and mainframes and allows users to communicate electronically. These four primary capabilities of the PC are vital to the needs of NASA's users and help to continue and support the vast amounts of work done by the NASA employees.

The web server of IBM's Bioinformatics and Pattern Discovery group.

PubMed

Huynh, Tien; Rigoutsos, Isidore; Parida, Laxmi; Platt, Daniel; Shibuya, Tetsuo

2003-07-01

We herein present and discuss the services and content which are available on the web server of IBM's Bioinformatics and Pattern Discovery group. The server is operational around the clock and provides access to a variety of methods that have been published by the group's members and collaborators. The available tools correspond to applications ranging from the discovery of patterns in streams of events and the computation of multiple sequence alignments, to the discovery of genes in nucleic acid sequences and the interactive annotation of amino acid sequences. Additionally, annotations for more than 70 archaeal, bacterial, eukaryotic and viral genomes are available on-line and can be searched interactively. The tools and code bundles can be accessed beginning at http://cbcsrv.watson.ibm.com/Tspd.html whereas the genomics annotations are available at http://cbcsrv.watson.ibm.com/Annotations/.

The web server of IBM's Bioinformatics and Pattern Discovery group

PubMed Central

Huynh, Tien; Rigoutsos, Isidore; Parida, Laxmi; Platt, Daniel; Shibuya, Tetsuo

2003-01-01

We herein present and discuss the services and content which are available on the web server of IBM's Bioinformatics and Pattern Discovery group. The server is operational around the clock and provides access to a variety of methods that have been published by the group's members and collaborators. The available tools correspond to applications ranging from the discovery of patterns in streams of events and the computation of multiple sequence alignments, to the discovery of genes in nucleic acid sequences and the interactive annotation of amino acid sequences. Additionally, annotations for more than 70 archaeal, bacterial, eukaryotic and viral genomes are available on-line and can be searched interactively. The tools and code bundles can be accessed beginning at http://cbcsrv.watson.ibm.com/Tspd.html whereas the genomics annotations are available at http://cbcsrv.watson.ibm.com/Annotations/. PMID:12824385

Investigation of triaxiality in 54122-128Xe isotopes in the framework of sdg-IBM

NASA Astrophysics Data System (ADS)

Jafarizadeh, M. A.; Ranjbar, Z.; Fouladi, N.; Ghapanvari, M.

In this paper, a transitional interacting boson model (IBM) Hamiltonian in both sd-(IBM) and sdg-IBM versions based on affine SU(1, 1) Lie algebra is employed to describe deviations from the gamma-unstable nature of Hamiltonian along the chain of Xe isotopes. sdg-IBM Hamiltonian proposed a better interpretation of this deviation which cannot be explained in the sd-boson models. The nuclei studied have well-known γ bands close to the γ-unstable limit. The energy levels, B(E2) transition rates and signature splitting of the γ -vibrational band are calculated via the affine SU(1,1) Lie algebra. An acceptable degree of agreement was achieved based on this procedure. It is shown that in these isotopes the signature splitting is better reproduced by the inclusion of sdg-IBM. In none of them, any evidence for a stable, triaxial ground state shape is found.

A performance evaluation of the IBM 370/XT personal computer

NASA Technical Reports Server (NTRS)

Dominick, Wayne D. (Editor); Triantafyllopoulos, Spiros

1984-01-01

An evaluation of the IBM 370/XT personal computer is given. This evaluation focuses primarily on the use of the 370/XT for scientific and technical applications and applications development. A measurement of the capabilities of the 370/XT was performed by means of test programs which are presented. Also included is a review of facilities provided by the operating system (VM/PC), along with comments on the IBM 370/XT hardware configuration.

76 FR 174 - International Business Machines (IBM), Global Sales Operations Organization, Sales and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-03

...] International Business Machines (IBM), Global Sales Operations Organization, Sales and Distribution Business Manager Roles; One Teleworker Located in Charleston, WV; International Business Machines (IBM), Global Sales Operations Organization, Sales and Distribution Business Unit, Relations Analyst and Band 8...

A Comparison of the Apple Macintosh and IBM PC in Laboratory Applications.

ERIC Educational Resources Information Center

Williams, Ron

1986-01-01

Compares Apple Macintosh and IBM PC microcomputers in terms of their usefulness in the laboratory. No attempt is made to equalize the two computer systems since they represent opposite ends of the computer spectrum. Indicates that the IBM PC is the most useful general-purpose personal computer for laboratory applications. (JN)

Data Mining and Knowledge Discover - IBM Cognitive Alternatives for NASA KSC

NASA Technical Reports Server (NTRS)

Velez, Victor Hugo

2016-01-01

Skillful tools in cognitive computing to transform industries have been found favorable and profitable for different Directorates at NASA KSC. In this study is shown how cognitive computing systems can be useful for NASA when computers are trained in the same way as humans are to gain knowledge over time. Increasing knowledge through senses, learning and a summation of events is how the applications created by the firm IBM empower the artificial intelligence in a cognitive computing system. NASA has explored and applied for the last decades the artificial intelligence approach specifically with cognitive computing in few projects adopting similar models proposed by IBM Watson. However, the usage of semantic technologies by the dedicated business unit developed by IBM leads these cognitive computing applications to outperform the functionality of the inner tools and present outstanding analysis to facilitate the decision making for managers and leads in a management information system.

75 FR 60141 - International Business Machines (IBM), Global Technology Services Delivery Division, Including On...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-29

... 25, 2010, applicable to workers of International Business Machines (IBM), Global Technology Services... hereby issued as follows: All workers of International Business Machines (IBM), Global Technology... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-74,164] International Business...

IBM techexplorer and MathML: Interactive Multimodal Scientific Documents

NASA Astrophysics Data System (ADS)

Diaz, Angel

2001-06-01

The World Wide Web provides a standard publishing platform for disseminating scientific and technical articles, books, journals, courseware, or even homework on the internet; however, the transition from paper to web-based interactive content has brought new opportunities for creating interactive content. Students, scientists, and engineers are now faced with the task of rendering the 2D presentational structure of mathematics, harnessing the wealth of scientific and technical software, and creating truly accessible scientific portals across international boundaries and markets. The recent emergence of World Wide Web Consortium (W3C) standards such as the Mathematical Markup Language (MathML), Language (XSL), and Aural CSS (ACSS) provide a foundation whereby mathematics can be displayed, enlivened, computed, and audio formatted. With interoperability ensured by standards, software applications can be easily brought together to create extensible and interactive scientific content. In this presentation we will provide an overview of the IBM techexplorer Hypermedia Browser, a web browser plug-in and ActiveX control aimed at bringing interactive mathematics to the masses across platforms and applications. We will demonstrate "live" mathematics where documents that contain MathML expressions can be edited and computed right inside your favorite web browser. This demonstration will be generalized as we show how MathML can be used to enliven even PowerPoint presentations. Finally, we will close the loop by demonstrating a novel approach to spoken mathematics based on MathML, DOM, XSL, ACSS, techexplorer, and IBM ViaVoice. By making use of techexplorer as the glue that binds the rendered content to the web browser, the back-end computation software, the Java applets that augment the exposition, and voice-rendering systems such as ViaVoice, authors can indeed create truly extensible and interactive scientific content. For more information see: [http://www.software.ibm

Desk-top publishing using IBM-compatible computers.

PubMed

Grencis, P W

1991-01-01

This paper sets out to describe one Medical Illustration Departments' experience of the introduction of computers for desk-top publishing. In this particular case, after careful consideration of all the options open, an IBM-compatible system was installed rather than the often popular choice of an Apple Macintosh.

Initial Performance Results on IBM POWER6

NASA Technical Reports Server (NTRS)

Saini, Subbash; Talcott, Dale; Jespersen, Dennis; Djomehri, Jahed; Jin, Haoqiang; Mehrotra, Piysuh

2008-01-01

The POWER5+ processor has a faster memory bus than that of the previous generation POWER5 processor (533 MHz vs. 400 MHz), but the measured per-core memory bandwidth of the latter is better than that of the former (5.7 GB/s vs. 4.3 GB/s). The reason for this is that in the POWER5+, the two cores on the chip share the L2 cache, L3 cache and memory bus. The memory controller is also on the chip and is shared by the two cores. This serializes the path to memory. For consistently good performance on a wide range of applications, the performance of the processor, the memory subsystem, and the interconnects (both latency and bandwidth) should be balanced. Recognizing this, IBM has designed the Power6 processor so as to avoid the bottlenecks due to the L2 cache, memory controller and buffer chips of the POWER5+. Unlike the POWER5+, each core in the POWER6 has its own L2 cache (4 MB - double that of the Power5+), memory controller and buffer chips. Each core in the POWER6 runs at 4.7 GHz instead of 1.9 GHz in POWER5+. In this paper, we evaluate the performance of a dual-core Power6 based IBM p6-570 system, and we compare its performance with that of a dual-core Power5+ based IBM p575+ system. In this evaluation, we have used the High- Performance Computing Challenge (HPCC) benchmarks, NAS Parallel Benchmarks (NPB), and four real-world applications--three from computational fluid dynamics and one from climate modeling.

Aircraft noise prediction program propeller analysis system IBM-PC version user's manual version 2.0

NASA Technical Reports Server (NTRS)

Nolan, Sandra K.

1988-01-01

The IBM-PC version of the Aircraft Noise Prediction Program (ANOPP) Propeller Analysis System (PAS) is a set of computational programs for predicting the aerodynamics, performance, and noise of propellers. The ANOPP-PAS is a subset of a larger version of ANOPP which can be executed on CDC or VAX computers. This manual provides a description of the IBM-PC version of the ANOPP-PAS and its prediction capabilities, and instructions on how to use the system on an IBM-XT or IBM-AT personal computer. Sections within the manual document installation, system design, ANOPP-PAS usage, data entry preprocessors, and ANOPP-PAS functional modules and procedures. Appendices to the manual include a glossary of ANOPP terms and information on error diagnostics and recovery techniques.

Networking DEC and IBM computers

NASA Technical Reports Server (NTRS)

Mish, W. H.

1983-01-01

Local Area Networking of DEC and IBM computers within the structure of the ISO-OSI Seven Layer Reference Model at a raw signaling speed of 1 Mops or greater are discussed. After an introduction to the ISO-OSI Reference Model nd the IEEE-802 Draft Standard for Local Area Networks (LANs), there follows a detailed discussion and comparison of the products available from a variety of manufactures to perform this networking task. A summary of these products is presented in a table.

76 FR 32231 - International Business Machines (IBM), Sales and Distribution Business Unit, Global Sales...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-03

... for the workers and former workers of International Business Machines (IBM), Sales and Distribution... reconsideration alleges that IBM outsourced to India and China. During the reconsideration investigation, it was..., Armonk, New York. The subject worker group supply computer software development and maintenance services...

Performance of the Mayo-IBM PAC system

NASA Astrophysics Data System (ADS)

Persons, Kenneth R.; Reardon, Frank J.; Gehring, Dale G.; Hangiandreou, Nicholas J.

1994-05-01

The Mayo Clinic and IBM (at Rochester, Minnesota) have jointly developed a picture archived system for use with Mayo's MRI and CT imaging modalities. This PACS is made up of over 50 computers that work cooperatively to provide archival, retrieval and image distribution services for Mayo's Department of Radiology. This paper will examine the performance characteristics of the system.

The GF11 project at IBM

NASA Astrophysics Data System (ADS)

Sexton, James C.

1990-08-01

The GF11 project at IBM's T. J. Watson Research Center is entering full production for QCD numerical calculations. This paper describes the GF11 hardware and system software, and discusses the first production program which has been developed to run on GF11. This program is a variation of the Cabbibo Marinari pure gauge Monte Carlo program for SU(3) and is currently sustaining almost 6 gigaflops on 360 processors in GF11.

Portability studies of modular data base managers. Interim reports. [Running CDC's DATATRAN 2 on IBM 360/370 and IBM's JOSHUA on CDC computers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kopp, H.J.; Mortensen, G.A.

1978-04-01

Approximately 60% of the full CDC 6600/7600 Datatran 2.0 capability was made operational on IBM 360/370 equipment. Sufficient capability was made operational to demonstrate adequate performance for modular program linking applications. Also demonstrated were the basic capabilities and performance required to support moderate-sized data base applications and moderately active scratch input/output applications. Approximately one to two calendar years are required to develop DATATRAN 2.0 capabilities fully for the entire spectrum of applications proposed. Included in the next stage of conversion should be syntax checking and syntax conversion features that would foster greater FORTRAN compatibility between IBM and CDC developed modules.more » The batch portion of the JOSHUA Modular System, which was developed by Savannah River Laboratory to run on an IBM computer, was examined for the feasibility of conversion to run on a Control Data Corporation (CDC) computer. Portions of the JOSHUA Precompiler were changed so as to be operable on the CDC computer. The Data Manager and Batch Monitor were also examined for conversion feasibility, but no changes were made in them. It appears to be feasible to convert the batch portion of the JOSHUA Modular System to run on a CDC computer with an estimated additional two to three man-years of effort. 9 tables.« less

76 FR 54800 - International Business Machines (IBM), Software Group Business Unit, Quality Assurance Group, San...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-02

... Machines (IBM), Software Group Business Unit, Quality Assurance Group, San Jose, California; Notice of... workers of International Business Machines (IBM), Software Group Business Unit, Optim Data Studio Tools QA... February 2, 2011 (76 FR 5832). The subject worker group supplies acceptance testing services, design...

The web server of IBM's Bioinformatics and Pattern Discovery group: 2004 update.

PubMed

Huynh, Tien; Rigoutsos, Isidore

2004-07-01

In this report, we provide an update on the services and content which are available on the web server of IBM's Bioinformatics and Pattern Discovery group. The server, which is operational around the clock, provides access to a large number of methods that have been developed and published by the group's members. There is an increasing number of problems that these tools can help tackle; these problems range from the discovery of patterns in streams of events and the computation of multiple sequence alignments, to the discovery of genes in nucleic acid sequences, the identification--directly from sequence--of structural deviations from alpha-helicity and the annotation of amino acid sequences for antimicrobial activity. Additionally, annotations for more than 130 archaeal, bacterial, eukaryotic and viral genomes are now available on-line and can be searched interactively. The tools and code bundles continue to be accessible from http://cbcsrv.watson.ibm.com/Tspd.html whereas the genomics annotations are available at http://cbcsrv.watson.ibm.com/Annotations/.

Two autowire versions for CDC-3200 and IBM-360

NASA Technical Reports Server (NTRS)

Billingsley, J. B.

1972-01-01

Microelectronics program was initiated to evaluate circuitry, packaging methods, and fabrication approaches necessary to produce completely procured logic system. Two autowire programs were developed for CDC-3200 and IBM-360 computers for use in designing logic systems.

A framework for WRF to WRF-IBM grid nesting to enable multiscale simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wiersema, David John; Lundquist, Katherine A.; Chow, Fotini Katapodes

With advances in computational power, mesoscale models, such as the Weather Research and Forecasting (WRF) model, are often pushed to higher resolutions. As the model’s horizontal resolution is refined, the maximum resolved terrain slope will increase. Because WRF uses a terrain-following coordinate, this increase in resolved terrain slopes introduces additional grid skewness. At high resolutions and over complex terrain, this grid skewness can introduce large numerical errors that require methods, such as the immersed boundary method, to keep the model accurate and stable. Our implementation of the immersed boundary method in the WRF model, WRF-IBM, has proven effective at microscalemore » simulations over complex terrain. WRF-IBM uses a non-conforming grid that extends beneath the model’s terrain. Boundary conditions at the immersed boundary, the terrain, are enforced by introducing a body force term to the governing equations at points directly beneath the immersed boundary. Nesting between a WRF parent grid and a WRF-IBM child grid requires a new framework for initialization and forcing of the child WRF-IBM grid. This framework will enable concurrent multi-scale simulations within the WRF model, improving the accuracy of high-resolution simulations and enabling simulations across a wide range of scales.« less

Sporadic-inclusion body myositis (s-IBM) is not so prevalent in Istanbul/Turkey: a muscle biopsy based survey.

PubMed

Oflazer, P Serdaroglu; Deymeer, F; Parman, Y

2011-06-01

In a muscle biopsy based study, only 9 out of 5450 biopsy samples, received from all parts of greater Istanbul area, had typical clinical and most suggestive light microscopic sporadic-inclusion body myositis (s-IBM) findings. Two other patients with and ten further patients without characteristic light microscopic findings had referring diagnosis of s-IBM. As the general and the age-adjusted populations of Istanbul in 2010 were 13.255.685 and 2.347.300 respectively, the calculated corresponding 'estimated prevalences' of most suggestive s-IBM in the Istanbul area were 0.679 X 10(-6) and 3.834 X 10(-6). Since Istanbul receives heavy migration from all regions of Turkey and ours is the only muscle pathology laboratory in Istanbul, projection of these figures to the Turkish population was considered to be reasonable and an estimate of the prevalence of s-IBM in Turkey was obtained. The calculated 'estimated prevalence' of s-IBM in Turkey is lower than the previously reported rates from other countries. The wide variation in the prevalence rates of s-IBM may reflect different genetic, immunogenetic or environmental factors in different populations.

Comparison of the AMDAHL 470V/6 and the IBM 370/195 using benchmarks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Snider, D.R.; Midlock, J.L.; Hinds, A.R.

1976-03-01

Six groups of jobs were run on the IBM 370/195 at the Applied Mathematics Division (AMD) of Argonne National Laboratory using the current production versions of OS/MVT 21.7 and ASP 3.1. The same jobs were then run on an AMDAHL 470V/6 at the AMDAHL manufacturing facilities in Sunnyvale, California, using the identical operating systems. Performances of the two machines are compared. Differences in the configurations were minimized. The memory size on each machine was the same, all software which had an impact on run times was the same, and the I/O configurations were as similar as possible. This allowed themore » comparison to be based on the relative performance of the two CPU's. As part of the studies preliminary to the acquisition of the IBM 195 in 1972, two of the groups of jobs had been run on a CDC 7600 by CDC personnel in Arden Hills, Minnesota, on an IBM 360/195 by IBM personnel in Poughkeepsie, New York, and on the AMD 360/50/75 production system in June, 1971. 6 figures, 9 tables.« less

REMOTE: Modem Communicator Program for the IBM personal computer

DOE Office of Scientific and Technical Information (OSTI.GOV)

McGirt, F.

1984-06-01

REMOTE, a Modem Communicator Program, was developed to provide full duplex serial communication with arbitrary remote computers via either dial-up telephone modems or direct lines. The latest version of REMOTE (documented in this report) was developed for the IBM Personal Computer.

76 FR 5832 - International Business Machines (IBM), Software Group Business Unit, Optim Data Studio Tools QA...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-02

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-74,554] International Business Machines (IBM), Software Group Business Unit, Optim Data Studio Tools QA, San Jose, CA; Notice of... determination of the TAA petition filed on behalf of workers at International Business Machines (IBM), Software...

The web server of IBM's Bioinformatics and Pattern Discovery group: 2004 update

PubMed Central

Huynh, Tien; Rigoutsos, Isidore

2004-01-01

In this report, we provide an update on the services and content which are available on the web server of IBM's Bioinformatics and Pattern Discovery group. The server, which is operational around the clock, provides access to a large number of methods that have been developed and published by the group's members. There is an increasing number of problems that these tools can help tackle; these problems range from the discovery of patterns in streams of events and the computation of multiple sequence alignments, to the discovery of genes in nucleic acid sequences, the identification—directly from sequence—of structural deviations from α-helicity and the annotation of amino acid sequences for antimicrobial activity. Additionally, annotations for more than 130 archaeal, bacterial, eukaryotic and viral genomes are now available on-line and can be searched interactively. The tools and code bundles continue to be accessible from http://cbcsrv.watson.ibm.com/Tspd.html whereas the genomics annotations are available at http://cbcsrv.watson.ibm.com/Annotations/. PMID:15215340

Mathematics Programming on the Apple II and IBM PC.

ERIC Educational Resources Information Center

Myers, Roy E.; Schneider, David I.

1987-01-01

Details the features of BASIC used in mathematics programming and provides the information needed to translate between the Apple II and IBM PC computers. Discusses inputing a user-defined function, setting scroll windows, displaying subscripts and exponents, variable names, mathematical characters and special symbols. (TW)

An Apple for Your IBM PC--The Quadlink Board.

ERIC Educational Resources Information Center

Owen, G. Scott

1984-01-01

Describes nature and installation of the QUADLINK board which allows Apple software to be run on IBM PC microcomputers. Although programs tested ran without problems, users should test their own programs since there are some copy protection schemes that can baffle the board. (JN)

Hazardous Waste Cleanup: IBM Corporation in Poughkeepsie, New York

EPA Pesticide Factsheets

This site covers approximately 423 acres, two-thirds of which is occupied by a manufacturing complex with more than 50 buildings. The land use in the area is a mix of industrial, commercial and residential. IBM is located approximately six miles south of t

Artifact-Based Transformation of IBM Global Financing

NASA Astrophysics Data System (ADS)

Chao, Tian; Cohn, David; Flatgard, Adrian; Hahn, Sandy; Linehan, Mark; Nandi, Prabir; Nigam, Anil; Pinel, Florian; Vergo, John; Wu, Frederick Y.

IBM Global Financing (IGF) is transforming its business using the Business Artifact Method, an innovative business process modeling technique that identifies key business artifacts and traces their life cycles as they are processed by the business. IGF is a complex, global business operation with many business design challenges. The Business Artifact Method is a fundamental shift in how to conceptualize, design and implement business operations. The Business Artifact Method was extended to solve the problem of designing a global standard for a complex, end-to-end process while supporting local geographic variations. Prior to employing the Business Artifact method, process decomposition, Lean and Six Sigma methods were each employed on different parts of the financing operation. Although they provided critical input to the final operational model, they proved insufficient for designing a complete, integrated, standard operation. The artifact method resulted in a business operations model that was at the right level of granularity for the problem at hand. A fully functional rapid prototype was created early in the engagement, which facilitated an improved understanding of the redesigned operations model. The resulting business operations model is being used as the basis for all aspects of business transformation in IBM Global Financing.

An Input Routine Using Arithmetic Statements for the IBM 704 Digital Computer

NASA Technical Reports Server (NTRS)

Turner, Don N.; Huff, Vearl N.

1961-01-01

An input routine has been designed for use with FORTRAN or SAP coded programs which are to be executed on an IBM 704 digital computer. All input to be processed by the routine is punched on IBM cards as declarative statements of the arithmetic type resembling the FORTRAN language. The routine is 850 words in length. It is capable of loading fixed- or floating-point numbers, octal numbers, and alphabetic words, and of performing simple arithmetic as indicated on input cards. Provisions have been made for rapid loading of arrays of numbers in consecutive memory locations.

Image acquisition unit for the Mayo/IBM PACS project

NASA Astrophysics Data System (ADS)

Reardon, Frank J.; Salutz, James R.

1991-07-01

The Mayo Clinic and IBM Rochester, Minnesota, have jointly developed a picture archiving, distribution and viewing system for use with Mayo's CT and MRI imaging modalities. Images are retrieved from the modalities and sent over the Mayo city-wide token ring network to optical storage subsystems for archiving, and to server subsystems for viewing on image review stations. Images may also be retrieved from archive and transmitted back to the modalities. The subsystems that interface to the modalities and communicate to the other components of the system are termed Image Acquisition Units (LAUs). The IAUs are IBM Personal System/2 (PS/2) computers with specially developed software. They operate independently in a network of cooperative subsystems and communicate with the modalities, archive subsystems, image review server subsystems, and a central subsystem that maintains information about the content and location of images. This paper provides a detailed description of the function and design of the Image Acquisition Units.

Ada (Trade Name) Compiler Validation Summary Report: IBM Corporation. IBM Development System for the Ada Language System, Version 1.1.0, IBM 4381 under VM/SP CMS, Release 3.6.

DTIC Science & Technology

1988-05-19

System for the Ada Language System, Version 1.1.0, 1.% International Business Machines Corporation, Wright-Patterson AFB. IBM 4381 under VM/SP CMS...THIS PAGE (When Data Enre’ed) AVF Control Number: AVF-VSR-82.1087 87-03-10-TEL ! Ada® COMPILER VALIDATION SUMMARY REPORT: International Business Machines...Organization (AVO). On-site testing was conducted from !8 May 1987 through 19 May 1987 at International Business Machines -orporation, San Diego CA. 1.2

An IBM-compatible program for interactive three-dimensional gravity modeling

NASA Astrophysics Data System (ADS)

Broome, John

1992-04-01

G3D is a 3-D interactive gravity modeling program for IBM-compatible microcomputers. The program allows a model to be created interactively by defining multiple tabular bodies with horizontal tops and bottoms. The resulting anomaly is calculated using Plouff's algorithm at up to 2000 predefined random or regularly located points. In order to display the anomaly as a color image, the point data are interpolated onto a regular grid and quantized into discrete intervals. Observed and residual gravity field images also can be generated. Adjustments to the model are made using a graphics cursor to move, insert, and delete body points or whole bodies. To facilitate model changes, planview body outlines can be overlain on any of the gravity field images during editing. The model's geometry can be displayed in planview or along a user-defined vertical section. G3D is written in Microsoft® FORTRAN and utilizes the Halo-Professional® (or Halo-88®) graphics subroutine library. The program is written for use on an IBM-compatible microcomputer equipped with hard disk, numeric coprocessor, and VGA, Number Nine Revolution (Halo-88® only), or TIGA® compatible graphics cards. A mouse or digitizing tablet is recommended for cursor positioning. Program source code, a user's guide, and sample data are available as Geological Survey of Canada Open File (G3D: A Three-dimensional Gravity Modeling Program for IBM-compatible Microcomputers).

Ada Compiler Validation Summary Report. Certificate Number: 891129W1. 10198 International Business Machines Corporation, the IBM Development System for the Ada Language AIX/RT Follow-on, Version 1.1 IBM RT Follow-on. Completion of On-Site Testing: 29 November 1989

DTIC Science & Technology

1989-11-29

nvmbe’j International Business Machines Corporation Wright-Patterson AFB, The IBM Development System for the Ada Language AIX/RT follow-on, Version 1.1...Certificate Number: 891129W1.10198 International Business Machines Corporation The IBM Development System for the Ada Language AIX/RT Follow-on, Version 1.1 IBM...scripts provided by International Business Machines Corporation and reviewed by the validation team. The compiler was tested using all the following

Ada Compiler Validation Summary Report: Certificate Number 880318W1. 09042, International Business Machines Corporation, IBM Development System for the Ada Language, Version 2.1.0, IBM 4381 under MVS/XA, Host and Target

DTIC Science & Technology

1988-03-28

International Business Machines Corporation IBM Development System for the Ada Language, Version 2.1.0 IBM 4381 under MVS/XA, host and target Completion...Joint Program Office, AJPO 20. ABSTRACT (Continue on reverse side if necessary and identify by block number) International Business Machines Corporation...in the compiler listed in this declaration. I declare that International Business Machines Corporation is the owner of record of the object code of

Ada Compiler Validation Summary Report: Certificate Number: 890420W1. 10066 International Business Machines Corporation, IBM Development System for the Ada Language, AIX/RT Ada Compiler, Version 1.1.1, IBM RT PC 6150-125

DTIC Science & Technology

1989-04-20

International Business Machines Corporation, IBM Development System. for the Ada Language AIX/RT Ada Compiler, Version 1.1.1, Wright-Patterson APB...Certificate Number: 890420V1.10066 International Business Machines Corporation IBM Development System for the Ada Language AIX/RT Ada Compiler, Version 1.1.1...TEST INFORMATION The compiler was tested using command scripts provided by International Business Machines Corporation and reviewed by the validation

IPEG- IMPROVED PRICE ESTIMATION GUIDELINES (IBM PC VERSION)

NASA Technical Reports Server (NTRS)

Aster, R. W.

1994-01-01

The Improved Price Estimation Guidelines, IPEG, program provides a simple yet accurate estimate of the price of a manufactured product. IPEG facilitates sensitivity studies of price estimates at considerably less expense than would be incurred by using the Standard Assembly-line Manufacturing Industry Simulation, SAMIS, program (COSMIC program NPO-16032). A difference of less than one percent between the IPEG and SAMIS price estimates has been observed with realistic test cases. However, the IPEG simplification of SAMIS allows the analyst with limited time and computing resources to perform a greater number of sensitivity studies than with SAMIS. Although IPEG was developed for the photovoltaics industry, it is readily adaptable to any standard assembly line type of manufacturing industry. IPEG estimates the annual production price per unit. The input data includes cost of equipment, space, labor, materials, supplies, and utilities. Production on an industry wide basis or a process wide basis can be simulated. Once the IPEG input file is prepared, the original price is estimated and sensitivity studies may be performed. The IPEG user selects a sensitivity variable and a set of values. IPEG will compute a price estimate and a variety of other cost parameters for every specified value of the sensitivity variable. IPEG is designed as an interactive system and prompts the user for all required information and offers a variety of output options. The IPEG/PC program is written in TURBO PASCAL for interactive execution on an IBM PC computer under DOS 2.0 or above with at least 64K of memory. The IBM PC color display and color graphics adapter are needed to use the plotting capabilities in IPEG/PC. IPEG/PC was developed in 1984. The original IPEG program is written in SIMSCRIPT II.5 for interactive execution and has been implemented on an IBM 370 series computer with a central memory requirement of approximately 300K of 8 bit bytes. The original IPEG was developed in 1980.

IPEG- IMPROVED PRICE ESTIMATION GUIDELINES (IBM 370 VERSION)

NASA Technical Reports Server (NTRS)

Chamberlain, R. G.

1994-01-01

The Improved Price Estimation Guidelines, IPEG, program provides a simple yet accurate estimate of the price of a manufactured product. IPEG facilitates sensitivity studies of price estimates at considerably less expense than would be incurred by using the Standard Assembly-line Manufacturing Industry Simulation, SAMIS, program (COSMIC program NPO-16032). A difference of less than one percent between the IPEG and SAMIS price estimates has been observed with realistic test cases. However, the IPEG simplification of SAMIS allows the analyst with limited time and computing resources to perform a greater number of sensitivity studies than with SAMIS. Although IPEG was developed for the photovoltaics industry, it is readily adaptable to any standard assembly line type of manufacturing industry. IPEG estimates the annual production price per unit. The input data includes cost of equipment, space, labor, materials, supplies, and utilities. Production on an industry wide basis or a process wide basis can be simulated. Once the IPEG input file is prepared, the original price is estimated and sensitivity studies may be performed. The IPEG user selects a sensitivity variable and a set of values. IPEG will compute a price estimate and a variety of other cost parameters for every specified value of the sensitivity variable. IPEG is designed as an interactive system and prompts the user for all required information and offers a variety of output options. The IPEG/PC program is written in TURBO PASCAL for interactive execution on an IBM PC computer under DOS 2.0 or above with at least 64K of memory. The IBM PC color display and color graphics adapter are needed to use the plotting capabilities in IPEG/PC. IPEG/PC was developed in 1984. The original IPEG program is written in SIMSCRIPT II.5 for interactive execution and has been implemented on an IBM 370 series computer with a central memory requirement of approximately 300K of 8 bit bytes. The original IPEG was developed in 1980.

COPYCAT; IBM OS system catalog utility routine. [IBM360,370; Assembly language

DOE Office of Scientific and Technical Information (OSTI.GOV)

Engert, D.E.

COPYCAT is an OS utility program designed to produce an efficient system-wide catalog which may reside on many volumes. Substantial improvement in performance may also be obtained on a system with only a single catalog. First, catalog entries from many different catalogs may be redistributed to equalize the load on each catalog. Second, each individual catalog is restructured in a way designed to minimize the I/O time required for searching and updating. Redistribution and restructuring parameters are under user control. Model DSCB's for generation data groups and alias entries are also processed. Catalogs on all direct access devices, including datamore » cells, are supported. Backup copies may also be made.IBM360,370; Assembly language; OS/MVT, OS/MFT, OS/VS1 and OS/VS2 Release 1; A large region size is recommended since COPYCAT will use all of the core available to it for buffers..« less

Maintenance of Microcomputers. Manual and Apple II Session, IBM Session.

ERIC Educational Resources Information Center

Coffey, Michael A.; And Others

This guide describes maintenance procedures for IBM and Apple personal computers, provides information on detecting and diagnosing problems, and details diagnostic programs. Included are discussions of printers, terminals, disks, disk drives, keyboards, hardware, and software. The text is supplemented by various diagrams. (EW)

Authoritarian Decision-Making and Alternative Patterns of Power and Influence: The Mexican IBM Case

DTIC Science & Technology

1988-05-01

34 p. 111. For a fuller treatment, see Olga Pellicer de Brody, "El Ilamado a las Inversiones extranjeras, 1953-1958," In Las Empresas Transnaclonales en ...Development, Hewlett-Packard, 27 February 1987. See also Steve Frazier, "Apple y Hewlett-Packard Contra una Empresa 100% de IBM en Mexico," Excelsior, 27...Heraldo. See "IBM Piensa Crear en Mexico una Planta de Microcomputadoras," El Heraldo, 22 January 1985. 125. Orme, ibid. 126. ibid. 127. It is just as

Diagnostic report acquisition unit for the Mayo/IBM PACS project

NASA Astrophysics Data System (ADS)

Brooks, Everett G.; Rothman, Melvyn L.

1991-07-01

The Mayo Clinic and IBM Rochester have jointly developed a picture archive and control system (PACS) for use with Mayo's MRI and Neuro-CT imaging modalities. One of the challenges of developing a useful PACS involves integrating the diagnostic reports with the electronic images so they can be displayed simultaneously. By the time a diagnostic report is generated for a particular case, its images have already been captured and archived by the PACS. To integrate the report with the images, the authors have developed an IBM Personal System/2 computer (PS/2) based diagnostic report acquisition unit (RAU). A typed copy of the report is transmitted via facsimile to the RAU where it is stacked electronically with other reports that have been sent previously but not yet processed. By processing these reports at the RAU, the information they contain is integrated with the image database and a copy of the report is archived electronically on an IBM Application System/400 computer (AS/400). When a user requests a set of images for viewing, the report is automatically integrated with the image data. By using a hot key, the user can toggle on/off the report on the display screen. This report describes process, hardware, and software employed to integrate the diagnostic report information into the PACS, including how the report images are captured, transmitted, and entered into the AS/400 database. Also described is how the archived reports and their associated medical images are located and merged for retrieval and display. The methods used to detect and process error conditions are also discussed.

A tale of two arcs? Plate tectonics of the Izu-Bonin-Mariana (IBM) arc using subducted slab constraints

NASA Astrophysics Data System (ADS)

Wu, J. E.; Suppe, J.; Renqi, L.; Kanda, R. V. S.

2014-12-01

Published plate reconstructions typically show the Izu-Bonin Marianas arc (IBM) forming as a result of long-lived ~50 Ma Pacific subduction beneath the Philippine Sea. These reconstructions rely on the critical assumption that the Philippine Sea was continuously coupled to the Pacific during the lifetime of the IBM arc. Because of this assumption, significant (up to 1500 km) Pacific trench retreat is required to accommodate the 2000 km of Philippine Sea/IBM northward motion since the Eocene that is constrained by paleomagnetic data. In this study, we have mapped subducted slabs of mantle lithosphere from MITP08 global seismic tomography (Li et al., 2008) and restored them to a model Earth surface to constrain plate tectonic reconstructions. Here we present two subducted slab constraints that call into question current IBM arc reconstructions: 1) The northern and central Marianas slabs form a sub-vertical 'slab wall' down to maximum 1500 km depths in the lower mantle. This slab geometry is best explained by a near-stationary Marianas trench that has remained +/- 250 km E-W of its present-day position since ~45 Ma, and does not support any significant Pacific slab retreat. 2) A vanished ocean is revealed by an extensive swath of sub-horizontal slabs at 700 to 1000 km depths in the lower mantle below present-day Philippine Sea to Papua New Guinea. We call this vanished ocean the 'East Asian Sea'. When placed in an Eocene plate reconstruction, the East Asian Sea fits west of the reconstructed Marianas Pacific trench position and north of the Philippine Sea plate. This implies that the Philippine Sea and Pacific were not adjacent at IBM initiation, but were in fact separated by a lost ocean. Here we propose a new IBM arc reconstruction constrained by subducted slabs mapped under East Asia. At ~50 Ma, the present-day IBM arc initiated at equatorial latitudes from East Asian Sea subduction below the Philippine Sea. A separate arc was formed from Pacific subduction below

Aberration correction results in the IBM STEM instrument.

PubMed

Batson, P E

2003-09-01

Results from the installation of aberration correction in the IBM 120 kV STEM argue that a sub-angstrom probe size has been achieved. Results and the experimental methods used to obtain them are described here. Some post-experiment processing is necessary to demonstrate the probe size of about 0.078 nm. While the promise of aberration correction is demonstrated, we remain at the very threshold of practicality, given the very stringent stability requirements.

Ada Compiler Validation Summary Report. Certificate Number: 900726W1. 11017, Verdix Corporation VADS IBM RISC System/6000, AIX 3.1, VAda-110-7171, Version 6.0 IBM RISC System/6000 Model 530 = IBM RISC System/6000 Model 530

DTIC Science & Technology

1991-01-22

Customer Agreement Number: 90-05-29- VRX See Section 3.1 for any additional information about the testing environment. As a result of this validation...22 January 1991 90-05-29- VRX Ada COMPILER VALIDATION SUMMARY REPORT: Certificate Number: 900726W1.11017 Verdix Corporation VADS IBM RISC System/6000

Using IBMs to Investigate Spatially-dependent Processes in Landscape Genetics Theory

EPA Science Inventory

Much of landscape and conservation genetics theory has been derived using non-spatialmathematical models. Here, we use a mechanistic, spatially-explicit, eco-evolutionary IBM to examine the utility of this theoretical framework in landscapes with spatial structure. Our analysis...

Modifications of the IBM personal computer synchronous communications support programs for use with the Multics

USGS Publications Warehouse

Kork, John O.

1983-01-01

Version 1.00 of the Asynchronous Communications Support supplied with the IBM Personal Computer must be modified to be used for communications with Multics. Version 2.00 can be used as supplied, but error checking and screen printing capabilities can be added by using modifications very similar to those required for Version 1.00. This paper describes and lists required programs on Multics and appropriate modifications to both Versions 1.00 and 2.00 of the programs supplied by IBM.

Generalized Information Architecture for Managing Requirements in IBM?s Rational DOORS(r) Application.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aragon, Kathryn M.; Eaton, Shelley M.; McCornack, Marjorie Turner

When a requirements engineering effort fails to meet expectations, often times the requirements management tool is blamed. Working with numerous project teams at Sandia National Laboratories over the last fifteen years has shown us that the tool is rarely the culprit; usually it is the lack of a viable information architecture with well- designed processes to support requirements engineering. This document illustrates design concepts with rationale, as well as a proven information architecture to structure and manage information in support of requirements engineering activities for any size or type of project. This generalized information architecture is specific to IBM's Rationalmore » DOORS (Dynamic Object Oriented Requirements System) software application, which is the requirements management tool in Sandia's CEE (Common Engineering Environment). This generalized information architecture can be used as presented or as a foundation for designing a tailored information architecture for project-specific needs. It may also be tailored for another software tool. Version 1.0 4 November 201« less

LION4; LION; three-dimensional temperature distribution program. [CDC6600,7600; UNIVAC1108; IBM360,370; FORTRAN IV and ASCENT (CDC6600,7600), FORTRAN IV (UNIVAC1108A,B and IBM360,370)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Binney, E.J.

LION4 is a computer program for calculating one-, two-, or three-dimensional transient and steady-state temperature distributions in reactor and reactor plant components. It is used primarily for thermal-structural analyses. It utilizes finite difference techniques with first-order forward difference integration and is capable of handling a wide variety of bounding conditions. Heat transfer situations accommodated include forced and free convection in both reduced and fully-automated temperature dependent forms, coolant flow effects, a limited thermal radiation capability, a stationary or stagnant fluid gap, a dual dependency (temperature difference and temperature level) heat transfer, an alternative heat transfer mode comparison and selection facilitymore » combined with heat flux direction sensor, and any form of time-dependent boundary temperatures. The program, which handles time and space dependent internal heat generation, can also provide temperature dependent material properties with limited non-isotropic properties. User-oriented capabilities available include temperature means with various weightings and a complete heat flow rate surveillance system.CDC6600,7600;UNIVAC1108;IBM360,370; FORTRAN IV and ASCENT (CDC6600,7600), FORTRAN IV (UNIVAC1108A,B and IBM360,370); SCOPE (CDC6600,7600), EXEC8 (UNIVAC1108A,B), OS/360,370 (IBM360,370); The CDC6600 version plotter routine LAPL4 is used to produce the input required by the associated CalComp plotter for graphical output. The IBM360 version requires 350K for execution and one additional input/output unit besides the standard units.« less

International Business Machines (IBM) Corporation Interim Agreement EPA Case No. 08-0113-00

EPA Pesticide Factsheets

On March 27, 2008, the United States Environmental Protection Agency (EPA), suspended International Business Machines (IBM) from receiving Federal Contracts, approved subcontracts, assistance, loans and other benefits.

A MAP read-routine for IBM 7094 Fortran II binary tapes

Treesearch

Robert S. Helfman

1966-01-01

Two MAP (Macro Assembly Program) language routines are descrived. They permit Fortran IV programs to read binary tapes generated by Fortran II programs, on the IBM 7090 and 7094 computers. One routine is for use with 7040/44-IBSYS, the other for 7090/94-IBSYS.

An IBM 370 assembly language program verifier

NASA Technical Reports Server (NTRS)

Maurer, W. D.

1977-01-01

The paper describes a program written in SNOBOL which verifies the correctness of programs written in assembly language for the IBM 360 and 370 series of computers. The motivation for using assembly language as a source language for a program verifier was the realization that many errors in programs are caused by misunderstanding or ignorance of the characteristics of specific computers. The proof of correctness of a program written in assembly language must take these characteristics into account. The program has been compiled and is currently running at the Center for Academic and Administrative Computing of The George Washington University.

Integrated Building Management System (IBMS)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anita Lewis

This project provides a combination of software and services that more easily and cost-effectively help to achieve optimized building performance and energy efficiency. Featuring an open-platform, cloud- hosted application suite and an intuitive user experience, this solution simplifies a traditionally very complex process by collecting data from disparate building systems and creating a single, integrated view of building and system performance. The Fault Detection and Diagnostics algorithms developed within the IBMS have been designed and tested as an integrated component of the control algorithms running the equipment being monitored. The algorithms identify the normal control behaviors of the equipment withoutmore » interfering with the equipment control sequences. The algorithms also work without interfering with any cooperative control sequences operating between different pieces of equipment or building systems. In this manner the FDD algorithms create an integrated building management system.« less

George E. Pake Prize Lecture: Physical Sciences Research at IBM: Still at the Cutting Edge

NASA Astrophysics Data System (ADS)

Theis, Thomas

2015-03-01

The information technology revolution is in its ``build out'' phase. The foundational scientific insights and hardware inventions are now many decades old. The microelectronics industry is maturing. An increasing fraction of the total research investment is in software and services, as applications of information technology transform every business and every sector of the public and private economy. Yet IBM Research continues to make substantial investments in hardware technology and the underlying physical sciences. While some of this investment is aimed at extending the established transistor technology, an increasing fraction is aimed at longer-term and possibly disruptive research - new devices for computing, such as tunneling field-effect transistors and nanophotonic circuits, and new architectures, such as neurosynaptic systems and quantum computing. This research investment is a bet that the old foundations of information technology are ripe for reinvention. After all, today's information technology devices and systems operate far from any fundamental limits on speed and energy efficiency. But how can IBM make risky long-term research investments in an era of global competition, with financial markets focused on the short term? One important answer is partnerships. Since its early days, IBM Research has pursued innovation in information technology and innovation in the ways it conducts the business of research. By continuously evolving new models for research and development partnerships, it has extended its global reach, increased its impact on IBM's customers, and expanded the breadth and depth of its research project portfolio. Research in the physical sciences has often led the way. Currently on assignment to the Semiconductor Research Corporation.

COMCAN; COMCAN2A; system safety common cause analysis. [IBM360; CDC CYBER176,175; FORTRAN IV (30%) and BAL (70%) (IBM360), FORTRAN IV (97%) and COMPASS (3%) (CDC CYBER176)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burdick, G.R.; Wilson, J.R.

COMCAN2A and COMCAN are designed to analyze complex systems such as nuclear plants for common causes of failure. A common cause event, or common mode failure, is a secondary cause that could contribute to the failure of more than one component and violates the assumption of independence. Analysis of such events is an integral part of system reliability and safety analysis. A significant common cause event is a secondary cause common to all basic events in one or more minimal cut sets. Minimal cut sets containing events from components sharing a common location or a common link are called commonmore » cause candidates. Components share a common location if no barrier insulates any one of them from the secondary cause. A common link is a dependency among components which cannot be removed by a physical barrier (e.g., a common energy source or common maintenance instructions).IBM360;CDC CYBER176,175; FORTRAN IV (30%) and BAL (70%) (IBM360), FORTRAN IV (97%) and COMPASS (3%) (CDC CYBER176).; OS/360 (IBM360) and NOS/BE 1.4 (CDC CYBER176), NOS 1.3 (CDC CYBER175); 140K bytes of memory for COMCAN and 242K (octal) words of memory for COMCAN2A.« less

Hazardous Waste Cleanup: IBM Corporation, Former in Hopewell Junction, New York

EPA Pesticide Factsheets

IBM's facility is located in Hopewell Junction, New York, bordered on the north by U.S. Route 52, to the east by County Highway 27, and to the south by U.S. Route 84. There is an unnamed creek next to the surrounding open fields to the west. The 592-acre

Conversion of LARSYS III.1 to an IBM 370 computer

NASA Technical Reports Server (NTRS)

Williams, G. N.; Leggett, J.; Hascall, G. A.

1975-01-01

A software system for processing multispectral aircraft or satellite data (LARSYS) was designed and written at the Laboratory for Applications of Remote Sensing at Purdue University. This system, being implemented on an IBM 360/67 computer utilizing the Cambridge Monitor System, is of an interactive nature. TAMU LARSYS maintains the essential capabilities of Purdue's LARSYS. The machine configuration for which it has been converted is an IBM-compatible Amdahl 470V/6 computer utilizing the time sharing option of the currently implemented OS/VS2 Operating System. Due to TSO limitations, the NASA-JSC deliverable TAMU LARSYS is comprised of two parts. Part one is a TSO Control Card Checker for LARSYS control cards, and part two is a batch version of LARSYS. Used together, they afford most of the capabilities of the original LARSYS III.1. Additionally, two programs have been written by TAMU to support LARSYS processing. The first is an ERTS-to-MIST conversion program used to convert ERTS data to the LARSYS input form, the MIST tape. The second is a system runtable code which maintains tape/file location information for the MIST data sets.

A Method for Transferring Photoelectric Photometry Data from Apple II+ to IBM PC

NASA Astrophysics Data System (ADS)

Powell, Harry D.; Miller, James R.; Stephenson, Kipp

1989-06-01

A method is presented for transferring photoelectric photometry data files from an Apple II computer to an IBM PC computer in a form which is compatible with the AAVSO Photoelectric Photometry data collection process.

High Resolution Displays In The Apple Macintosh And IBM PC Environments

NASA Astrophysics Data System (ADS)

Winegarden, Steven

1989-07-01

High resolution displays are one of the key elements that distinguish user oriented document finishing or publishing stations. A number of factors have been involved in bringing these to the desktop environment. At Sigma Designs we have concentrated on enhancing the capabilites of IBM PCs and compatibles and Apple Macintosh computer systems.

98. View of IBM digital computer model 7090 magnet core ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

98. View of IBM digital computer model 7090 magnet core installation. ITT Artic Services, Inc., Official photograph BMEWS Site II, Clear, AK, by unknown photographer, 17 September 1965. BMEWS, clear as negative no. A-6606. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

SAP- FORTRAN STATIC SOURCE CODE ANALYZER PROGRAM (IBM VERSION)

NASA Technical Reports Server (NTRS)

Manteufel, R.

1994-01-01

The FORTRAN Static Source Code Analyzer program, SAP, was developed to automatically gather statistics on the occurrences of statements and structures within a FORTRAN program and to provide for the reporting of those statistics. Provisions have been made for weighting each statistic and to provide an overall figure of complexity. Statistics, as well as figures of complexity, are gathered on a module by module basis. Overall summed statistics are also accumulated for the complete input source file. SAP accepts as input syntactically correct FORTRAN source code written in the FORTRAN 77 standard language. In addition, code written using features in the following languages is also accepted: VAX-11 FORTRAN, IBM S/360 FORTRAN IV Level H Extended; and Structured FORTRAN. The SAP program utilizes two external files in its analysis procedure. A keyword file allows flexibility in classifying statements and in marking a statement as either executable or non-executable. A statistical weight file allows the user to assign weights to all output statistics, thus allowing the user flexibility in defining the figure of complexity. The SAP program is written in FORTRAN IV for batch execution and has been implemented on a DEC VAX series computer under VMS and on an IBM 370 series computer under MVS. The SAP program was developed in 1978 and last updated in 1985.

Transfer of numeric ASCII data files between Apple and IBM personal computers.

PubMed

Allan, R W; Bermejo, R; Houben, D

1986-01-01

Listings for programs designed to transfer numeric ASCII data files between Apple and IBM personal computers are provided with accompanying descriptions of how the software operates. Details of the hardware used are also given. The programs may be easily adapted for transferring data between other microcomputers.

UFO: A THREE-DIMENSIONAL NEUTRON DIFFUSION CODE FOR THE IBM 704

DOE Office of Scientific and Technical Information (OSTI.GOV)

Auerbach, E.H.; Jewett, J.P.; Ketchum, M.A.

A description of UFO, a code for the solution of the fewgroup neutron diffusion equation in three-dimensional Cartesian coordinates on the IBM 704, is given. An accelerated Liebmann flux iteration scheme is used, and optimum parameters can be calculated by the code whenever they are required. The theory and operation of the program are discussed. (auth)

Performance assessment of KORAT-3D on the ANL IBM-SP computer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Alexeyev, A.V.; Zvenigorodskaya, O.A.; Shagaliev, R.M.

1999-09-01

The TENAR code is currently being developed at the Russian Federal Nuclear Center (VNIIEF) as a coupled dynamics code for the simulation of transients in VVER and RBMK systems and other nuclear systems. The neutronic module in this code system is KORAT-3D. This module is also one of the most computationally intensive components of the code system. A parallel version of KORAT-3D has been implemented to achieve the goal of obtaining transient solutions in reasonable computational time, particularly for RBMK calculations that involve the application of >100,000 nodes. An evaluation of the KORAT-3D code performance was recently undertaken on themore » Argonne National Laboratory (ANL) IBM ScalablePower (SP) parallel computer located in the Mathematics and Computer Science Division of ANL. At the time of the study, the ANL IBM-SP computer had 80 processors. This study was conducted under the auspices of a technical staff exchange program sponsored by the International Nuclear Safety Center (INSC).« less

IBM Academic Information Systems University AEP Conference: "Tools for Learning" (2nd, San Diego, California, April 5-8, 1986). Agenda [and Abstracts].

ERIC Educational Resources Information Center

International Business Machines Corp., Milford, CT. Academic Information Systems.

This agenda lists activities scheduled for the second IBM (International Business Machines) Academic Information Systems University AEP (Advanced Education Projects) Conference, which was designed to afford the universities participating in the IBM-sponsored AEPs an opportunity to demonstrate their AEP experiments in educational computing. In…

97. View of International Business Machine (IBM) digital computer model ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

97. View of International Business Machine (IBM) digital computer model 7090 magnetic core installation, international telephone and telegraph (ITT) Artic Services Inc., Official photograph BMEWS site II, Clear, AK, by unknown photographer, 17 September 1965, BMEWS, clear as negative no. A-6604. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

Performance statistics of the FORTRAN 4 /H/ library for the IBM system/360

NASA Technical Reports Server (NTRS)

Clark, N. A.; Cody, W. J., Jr.; Hillstrom, K. E.; Thieleker, E. A.

1969-01-01

Test procedures and results for accuracy and timing tests of the basic IBM 360/50 FORTRAN 4 /H/ subroutine library are reported. The testing was undertaken to verify performance capability and as a prelude to providing some replacement routines of improved performance.

Computing Legacy Software Behavior to Understand Functionality and Security Properties: An IBM/370 Demonstration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Linger, Richard C; Pleszkoch, Mark G; Prowell, Stacy J

Organizations maintaining mainframe legacy software can benefit from code modernization and incorporation of security capabilities to address the current threat environment. Oak Ridge National Laboratory is developing the Hyperion system to compute the behavior of software as a means to gain understanding of software functionality and security properties. Computation of functionality is critical to revealing security attributes, which are in fact specialized functional behaviors of software. Oak Ridge is collaborating with MITRE Corporation to conduct a demonstration project to compute behavior of legacy IBM Assembly Language code for a federal agency. The ultimate goal is to understand functionality and securitymore » vulnerabilities as a basis for code modernization. This paper reports on the first phase, to define functional semantics for IBM Assembly instructions and conduct behavior computation experiments.« less

Continued Development of Internet Protocols under the IBM OS/MVS Operating System

DTIC Science & Technology

1985-01-25

developed a prototype TCP/IP implementation for an IBM MVS host under a previous DARPA contract’ as part of the Internet research effort on the design of...participated in the DARPA Internet research program which led to the present TCP and IP protocols. Development of a prototype implementation of TCP/IP

The study of structure in 224-234 thorium nuclei within the framework IBM

NASA Astrophysics Data System (ADS)

Lee, Su Youn; Lee, Young Jun; Lee, J. H.

2017-09-01

An investigation has been made of the behaviour of nuclear structure as a function of an increase in neutron number from 224Th to 234Th. Thorium of mass number 234 is a typical rotor nucleus that can be explained by the SU(3) limit of the interacting boson model(IBM) in the algebraic nuclear model. Furthermore, 224-232Th lie on the path of the symmetry-breaking phase transition. Moreover, the nuclear structure of 224Th can be explained using X(5) symmetry. However, as 226-230Th nuclei are not fully symmetrical nuclei, they can be represented by adding a perturbed term to express symmetry breaking. Through the following three calculation steps, we identified the tendency of change in nuclear structure. Firstly, the structure of 232Th is described using the matrix elements of the Hamiltonian and the electric quadrupole operator between basis states of the SU(3) limit in IBM. Secondly, the low-lying energy levels and E2 transition ratios corresponding to the observable physical values are calculated by adding a perturbed term with the first-order Casimir operator of the U(5) limit to the SU(3) Hamiltonian in IBM. We compared the results with experimental data of 224-234Th. Lastly, the potential of the Bohr Hamiltonian is represented by a harmonic oscillator, as a result of which the structure of 224-234Th could be expressed in closed form by an approximate separation of variables. The results of these theoretical predictions clarify nuclear structure changes in Thorium nuclei over mass numbers of practical significance.

Bill Lang's contributions to acoustics at International Business Machines Corporation (IBM), signal processing, international standards, and professionalism in noise control engineering

NASA Astrophysics Data System (ADS)

Maling, George C.

2005-09-01

Bill Lang joined IBM in the late 1950s with a mandate from Thomas Watson Jr. himself to establish an acoustics program at IBM. Bill created the facilities in Poughkeepsie, developed the local program, and was the leader in having other IBM locations with development and manufacturing responsibilities construct facilities and hire staff under the Interdivisional Liaison Program. He also directed IBMs acoustics technology program. In the mid-1960s, he led an IEEE standards group in Audio and Electroacoustics, and, with the help of James Cooley, Peter Welch, and others, introduced the fast Fourier transform to the acoustics community. He was the convenor of ISO TC 43 SC1 WG6 that began writing the 3740 series of standards in the 1970s. It was his suggestion to promote professionalism in noise control engineering, and, through meetings with Leo Beranek and others, led the founding of INCE/USA in 1971. He was also a leader of the team that founded International INCE in 1974, and he served as president from 1988 until 1999.

Making IBM's Computer, Watson, Human

PubMed Central

Rachlin, Howard

2012-01-01

This essay uses the recent victory of an IBM computer (Watson) in the TV game, Jeopardy, to speculate on the abilities Watson would need, in addition to those it has, to be human. The essay's basic premise is that to be human is to behave as humans behave and to function in society as humans function. Alternatives to this premise are considered and rejected. The viewpoint of the essay is that of teleological behaviorism. Mental states are defined as temporally extended patterns of overt behavior. From this viewpoint (although Watson does not currently have them), essential human attributes such as consciousness, the ability to love, to feel pain, to sense, to perceive, and to imagine may all be possessed by a computer. Most crucially, a computer may possess self-control and may act altruistically. However, the computer's appearance, its ability to make specific movements, its possession of particular internal structures (e.g., whether those structures are organic or inorganic), and the presence of any nonmaterial “self,” are all incidental to its humanity. PMID:22942530

Making IBM's Computer, Watson, Human.

PubMed

Rachlin, Howard

2012-01-01

This essay uses the recent victory of an IBM computer (Watson) in the TV game, Jeopardy, to speculate on the abilities Watson would need, in addition to those it has, to be human. The essay's basic premise is that to be human is to behave as humans behave and to function in society as humans function. Alternatives to this premise are considered and rejected. The viewpoint of the essay is that of teleological behaviorism. Mental states are defined as temporally extended patterns of overt behavior. From this viewpoint (although Watson does not currently have them), essential human attributes such as consciousness, the ability to love, to feel pain, to sense, to perceive, and to imagine may all be possessed by a computer. Most crucially, a computer may possess self-control and may act altruistically. However, the computer's appearance, its ability to make specific movements, its possession of particular internal structures (e.g., whether those structures are organic or inorganic), and the presence of any nonmaterial "self," are all incidental to its humanity.

Current status of the joint Mayo Clinic-IBM PACS project

NASA Astrophysics Data System (ADS)

Hangiandreou, Nicholas J.; Williamson, Byrn, Jr.; Gehring, Dale G.; Persons, Kenneth R.; Reardon, Frank J.; Salutz, James R.; Felmlee, Joel P.; Loewen, M. D.; Forbes, Glenn S.

1994-05-01

A multi-phase collaboration between Mayo Clinic and IBM-Rochester was undertaken, with the goal of developing a picture archiving and communication system for routine clinical use in the Radiology Department. The initial phase of this project (phase 0) was started in 1988. The current system has been fully integrated into the clinical practice and, to date, over 6.5 million images from 16 imaging modalities have been archived. Phase 3 of this project has recently concluded.

The Upper- to Middle-Crustal Section of the Alisitos Oceanic Arc, (Baja, Mexico): an Analog of the Izu-Bonin-Marianas (IBM) Arc

NASA Astrophysics Data System (ADS)

Medynski, S.; Busby, C.; DeBari, S. M.; Morris, R.; Andrews, G. D.; Brown, S. R.; Schmitt, A. K.

2016-12-01

The Rosario segment of the Cretaceous Alisitos arc in Baja California is an outstanding field analog for the Izu-Bonin-Mariana (IBM) arc, because it is structurally intact, unmetamorphosed, and has superior three-dimensional exposures of an upper- to middle-crustal section through an extensional oceanic arc. Previous work1, done in the pre-digital era, used geologic mapping to define two phases of arc evolution, with normal faulting in both phases: (1) extensional oceanic arc, with silicic calderas, and (2) oceanic arc rifting, with widespread diking and dominantly mafic effusions. Our new geochemical data match the extensional zone immediately behind the Izu arc front, and is different from the arc front and rear arc, consistent with geologic relations. Our study is developing a 3D oceanic arc crustal model, with geologic maps draped on Google Earth images, and GPS-located outcrop information linked to new geochemical, geochronological and petrographic data, with the goal of detailing the relationships between plutonic, hypabyssal, and volcanic rocks. This model will be used by scientists as a reference model for past (IBM-1, 2, 3) and proposed IBM (IBM-4) drilling activities. New single-crystal zircon analysis by TIMS supports the interpretation, based on batch SIMS analysis of chemically-abraded zircon1, that the entire upper-middle crustal section accumulated in about 1.5 Myr. Like the IBM, volcanic zircons are very sparse, but zircon chemistry on the plutonic rocks shows trace element compositions that overlap to those measured in IBM volcanic zircons by A. Schmitt (unpublished data). Zircons have U-Pb ages up to 20 Myr older than the eruptive age, suggesting remelting of older parts of the arc, similar to that proposed for IBM (using different evidence). Like IBM, some very old zircons are also present, indicating the presence of old crustal fragments, or sediments derived from them, in the basement. However, our geochemical data show that the magmas are

CLIPS - C LANGUAGE INTEGRATED PRODUCTION SYSTEM (IBM PC VERSION)

NASA Technical Reports Server (NTRS)

Riley, G.

1994-01-01

The C Language Integrated Production System, CLIPS, is a shell for developing expert systems. It is designed to allow artificial intelligence research, development, and delivery on conventional computers. The primary design goals for CLIPS are portability, efficiency, and functionality. For these reasons, the program is written in C. CLIPS meets or outperforms most micro- and minicomputer based artificial intelligence tools. CLIPS is a forward chaining rule-based language. The program contains an inference engine and a language syntax that provide a framework for the construction of an expert system. It also includes tools for debugging an application. CLIPS is based on the Rete algorithm, which enables very efficient pattern matching. The collection of conditions and actions to be taken if the conditions are met is constructed into a rule network. As facts are asserted either prior to or during a session, CLIPS pattern-matches the number of fields. Wildcards and variables are supported for both single and multiple fields. CLIPS syntax allows the inclusion of externally defined functions (outside functions which are written in a language other than CLIPS). CLIPS itself can be embedded in a program such that the expert system is available as a simple subroutine call. Advanced features found in CLIPS version 4.3 include an integrated microEMACS editor, the ability to generate C source code from a CLIPS rule base to produce a dedicated executable, binary load and save capabilities for CLIPS rule bases, and the utility program CRSV (Cross-Reference, Style, and Verification) designed to facilitate the development and maintenance of large rule bases. Five machine versions are available. Each machine version includes the source and the executable for that machine. The UNIX version includes the source and binaries for IBM RS/6000, Sun3 series, and Sun4 series computers. The UNIX, DEC VAX, and DEC RISC Workstation versions are line oriented. The PC version and the Macintosh

The IBM PC as an Online Search Machine--Part 2: Physiology for Searchers.

ERIC Educational Resources Information Center

Kolner, Stuart J.

1985-01-01

Enumerates "hardware problems" associated with use of the IBM personal computer as an online search machine: purchase of machinery, unpacking of parts, and assembly into a properly functioning computer. Components that allow transformations of computer into a search machine (combination boards, printer, modem) and diagnostics software…

A performance comparison of the IBM RS/6000 and the Astronautics ZS-1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, W.M.; Abraham, S.G.; Davidson, E.S.

1991-01-01

Concurrent uniprocessor architectures, of which vector and superscalar are two examples, are designed to capitalize on fine-grain parallelism. The authors have developed a performance evaluation method for comparing and improving these architectures, and in this article they present the methodology and a detailed case study of two machines. The runtime of many programs is dominated by time spent in loop constructs - for example, Fortran Do-loops. Loops generally comprise two logical processes: The access process generates addresses for memory operations while the execute process operates on floating-point data. Memory access patterns typically can be generated independently of the data inmore » the execute process. This independence allows the access process to slip ahead, thereby hiding memory latency. The IBM 360/91 was designed in 1967 to achieve slip dynamically, at runtime. One CPU unit executes integer operations while another handles floating-point operations. Other machines, including the VAX 9000 and the IBM RS/6000, use a similar approach.« less

A MAP fixed-point, packing-unpacking routine for the IBM 7094 computer

Treesearch

Robert S. Helfman

1966-01-01

Two MAP (Macro Assembly Program) computer routines for packing and unpacking fixed point data are described. Use of these routines with Fortran IV Programs provides speedy access to quantities of data which far exceed the normal storage capacity of IBM 7000-series computers. Many problems that could not be attempted because of the slow access-speed of tape...

Hazardous Waste Cleanup: IBM Corporation-TJ Watson Research Center in Yorktown Heights, New York

EPA Pesticide Factsheets

IBM Corporation -TJ Watson Research Center is located in southern Yorktown near the boundary separating the Town of Yorktown from the Town of New Castle. The site occupies an area of approximately 217 acres and adjoins land uses are predominantly residenti

A Version of the Graphics-Oriented Interactive Finite Element Time-Sharing System (GIFTS) for an IBM with CP/CMS.

DTIC Science & Technology

1982-03-01

POSTGRADUATE SCHOOL fMonterey, California THESIS A VERSION OF THE GRAPHICS-ORIENTED INTERACTIVE FINITE ELEMENT TIME-SHARING SYSTEM ( GIFTS ) FOR AN IBM...Master’s & Engineer’s active Finite Element Time-sharing System Thesis - March 1982 ( GIFTS ) for an IBM with CP/CMS 6. penromm.oOn. REPoRT MUlmiR 1. AUTHOIee...ss0in D dinuf 5W M memisi) ’A version of the Graphics-oriented, Interactive, Finite element, Time-sharing System ( GIFTS ) has been developed for, and

The IBM PC as an Online Search Machine. Part 5: Searching through Crosstalk.

ERIC Educational Resources Information Center

Kolner, Stuart J.

1985-01-01

This last of a five-part series on using the IBM personal computer for online searching highlights a brief review, search process, making the connection, switching between screens and modes, online transaction, capture buffer controls, coping with options, function keys, script files, processing downloaded information, note to TELEX users, and…

The POIS (Parkland On-Line Information System) Implementation of the IBM Health Care Support/Patient Care System

PubMed Central

Mishelevich, David J.; Hudson, Betty G.; Van Slyke, Donald; Mize, Elaine I.; Robinson, Anna L.; Brieden, Helen C.; Atkinson, Jack; Robertson, James

1980-01-01

The installation of major components of a comprehensive Hospital Information System (HIS) called POIS, the Parkland On-line Information System, including identified success factors is described for the Dallas County Hospital District (DCHD) known also as the Parkland Memorial Hospital. Installation of the on-line IBM Health Care Support (HCS) Registration and Admissions Packages occurred in 1976 and implementation of the HCS Patient Care System (PCS) began in 1977 which includes on-line support of health care areas such as nursing stations and ancillary areas. The Duke Hospital Information System (DHIS) is marketed as the IBM HCS/Patient Care System (PCS). DCHD was the validation site. POIS has order entry, result reporting and work management components. While most of the patient care components are currently installed for the inpatient service, the Laboratories are being installed for the outpatient and Emergency areas as well. The Clinic Appointment System developed at the University of Michigan is also installed. The HCS family of programs use DL/1 and CICS and were installed in the OS versions, currently running under MVS on an IBM 370/168 Model 3 with 8 megabytes of main memory. ImagesFigure 1-AFigure 1-B

Demonstration of entanglement assisted invariance on IBM's quantum experience.

PubMed

Deffner, Sebastian

2017-11-01

Quantum entanglement is among the most fundamental, yet from classical intuition also most surprising properties of the fully quantum nature of physical reality. We report several experiments performed on IBM's Quantum Experience demonstrating envariance - entanglement assisted invariance. Envariance is a recently discovered symmetry of composite quantum systems, which is at the foundational origin of physics and a quantum phenomenon of pure states. These very easily reproducible and freely accessible experiments on Quantum Experience provide simple tools to study the properties of envariance, and we illustrate this for several cases with "quantum universes" consisting of up to five qubits.

76 FR 21033 - International Business Machines (IBM), Sales and Distribution Business Unit, Global Sales...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-14

... of the negative determination regarding workers' eligibility to apply for Trade Adjustment Assistance (TAA) applicable to workers and former workers of International Business Machines (IBM), Sales and... was published in the Federal Register on November 17, 2010 (75 FR 70296). The workers supply computer...

Cost-benefit study of consumer product take-back programs using IBM's WIT reverse logistics optimization tool

NASA Astrophysics Data System (ADS)

Veerakamolmal, Pitipong; Lee, Yung-Joon; Fasano, J. P.; Hale, Rhea; Jacques, Mary

2002-02-01

In recent years, there has been increased focus by regulators, manufacturers, and consumers on the issue of product end of life management for electronics. This paper presents an overview of a conceptual study designed to examine the costs and benefits of several different Product Take Back (PTB) scenarios for used electronics equipment. The study utilized a reverse logistics supply chain model to examine the effects of several different factors in PTB programs. The model was done using the IBM supply chain optimization tool known as WIT (Watson Implosion Technology). Using the WIT tool, we were able to determine a theoretical optimal cost scenario for PTB programs. The study was designed to assist IBM internally in determining theoretical optimal Product Take Back program models and determining potential incentives for increasing participation rates.

Using NetMaster to manage IBM networks

NASA Technical Reports Server (NTRS)

Ginsburg, Guss

1991-01-01

After defining a network and conveying its importance to support the activities at the JSC, the need for network management based on the size and complexity of the IBM SNA network at JSC is demonstrated. Network Management consists of being aware of component status and the ability to control resources to meet the availability and service needs of users. The concerns of the user are addressed as well as those of the staff responsible for managing the network. It is explained how NetMaster (a network management system for managing SNA networks) is used to enhance reliability and maximize service to SNA network users through automated procedures. The following areas are discussed: customization, problem and configuration management, and system measurement applications of NetMaster. Also, several examples are given that demonstrate NetMaster's ability to manage and control the network, integrate various product functions, as well as provide useful management information.

Performance characteristics of the Mayo/IBM PACS

NASA Astrophysics Data System (ADS)

Persons, Kenneth R.; Gehring, Dale G.; Pavicic, Mark J.; Ding, Yingjai

1991-07-01

The Mayo Clinic and IBM (at Rochester, Minnesota) have jointly developed a picture archiving system for use with Mayo's MRI and Neuro CT imaging modalities. The communications backbone of the PACS is a portion of the Mayo institutional network: a series of 4-Mbps token rings interconnected by bridges and fiber optic extensions. The performance characteristics of this system are important to understand because they affect the response time a PACS user can expect, and the response time for non-PACS users competing for resources on the institutional network. The performance characteristics of each component and the average load levels of the network were measured for various load distributions. These data were used to quantify the response characteristics of the existing system and to tune a model developed by North Dakota State University Department of Computer Science for predicting response times of more complex topologies.

Study of Even-Even/Odd-Even/Odd-Odd Nuclei in Zn-Ga-Ge Region in the Proton-Neutron IBM/IBFM/IBFFM

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yoshida, N.; Brant, S.; Zuffi, L.

We study the even-even, odd-even and odd-odd nuclei in the region including Zn-Ga-Ge in the proton-neutron IBM and the models derived from it: IBM2, IBFM2, IBFFM2. We describe {sup 67}Ga, {sup 65}Zn, and {sup 68}Ga by coupling odd particles to a boson core {sup 66}Zn. We also calculate the beta{sup +}-decay rates among {sup 68}Ge, {sup 68}Ga and {sup 68}Zn.

Letter from Hong Kong: A Report on Chinese Food, Fake Apples, and IBM's Asian Strategy.

ERIC Educational Resources Information Center

Immel, A. Richard

1984-01-01

Notes that microcomputer use in Hong Kong's small business community does not reflect the growth of its high-tech electronics industry and discusses IBM's influence in Hong Kong and Asia, the counterfeiting of Apple microcomputers and software, and why Apple currently has no recourse. (MBR)

IBM system/360 assembly language interval arithmetic software

NASA Technical Reports Server (NTRS)

Phillips, E. J.

1972-01-01

Computer software designed to perform interval arithmetic is described. An interval is defined as the set of all real numbers between two given numbers including or excluding one or both endpoints. Interval arithmetic consists of the various elementary arithmetic operations defined on the set of all intervals, such as interval addition, subtraction, union, etc. One of the main applications of interval arithmetic is in the area of error analysis of computer calculations. For example, it has been used sucessfully to compute bounds on sounding errors in the solution of linear algebraic systems, error bounds in numerical solutions of ordinary differential equations, as well as integral equations and boundary value problems. The described software enables users to implement algorithms of the type described in references efficiently on the IBM 360 system.

NJE; VAX-VMS IBM NJE network protocol emulator. [DEC VAX11/780; VAX-11 FORTRAN 77 (99%) and MACRO-11 (1%)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Engert, D.E.; Raffenetti, C.

NJE is communications software developed to enable a VAX VMS system to participate as an end-node in a standard IBM network by emulating the Network Job Entry (NJE) protocol. NJE supports job networking for the operating systems used on most large IBM-compatible computers (e.g., VM/370, MVS with JES2 or JES3, SVS, MVT with ASP or HASP). Files received by the VAX can be printed or saved in user-selected disk files. Files sent to the network can be routed to any network node for printing, punching, or job submission, or to a VM/370 user's virtual reader. Files sent from the VAXmore » are queued and transmitted asynchronously. No changes are required to the IBM software.DEC VAX11/780; VAX-11 FORTRAN 77 (99%) and MACRO-11 (1%); VMS 2.5; VAX11/780 with DUP-11 UNIBUS interface and 9600 baud synchronous modem..« less

Materials accounting system for an IBM PC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bearse, R.C.; Thomas, R.J.; Henslee, S.P.

1986-01-01

We have adapted the Los Alamos MASS accounting system for use on an IBM PC/AT at the Fuels Manufacturing Facility (FMF) at Argonne National Laboratory-West (ANL-WEST) in Idaho Falls, Idaho. Cost of hardware and proprietary software was less than $10,000 per station. The system consists of three stations between which accounting information is transferred using floppy disks accompanying special nuclear material shipments. The programs were implemented in dBASEIII and were compiled using the proprietary software CLIPPER. Modifications to the inventory can be posted in just a few minutes, and operator/computer interaction is nearly instantaneous. After the records are built bymore » the user, it takes 4 to 5 seconds to post the results to the database files. A version of this system was specially adapted and is currently in use at the FMF facility at Argonne National Laboratory in Idaho Falls. Initial satisfaction is adequate and software and hardware problems are minimal.« less

MOLECULAR DESIGNER: an interactive program for the display of protein structure on the IBM-PC.

PubMed

Hannon, G J; Jentoft, J E

1985-09-01

A BASIC interactive graphics program has been developed for the IBM-PC which utilizes the graphics capabilities of that computer to display and manipulate protein structure from coordinates. Structures may be generated from typed files, or from Brookhaven National Laboratories' Protein Data Bank data tapes. Once displayed, images may be rotated, translated and expanded to any desired size. Figures may be viewed as ball-and-stick or space-filling models. Calculated multiple-point perspective may also be added to the display. Docking manipulations are possible since more than a single figure may be displayed and manipulated simultaneously. Further, stereo images and red/blue three-dimensional images may be generated using the accompanying DESIPLOT program and an HP-7475A plotter. A version of the program is also currently available for the Apple Macintosh. Full implementation on the Macintosh requires 512 K and at least one disk drive. Otherwise this version is essentially identical to the IBM-PC version described herein.

CLIPS - C LANGUAGE INTEGRATED PRODUCTION SYSTEM (IBM PC VERSION WITH CLIPSITS)

NASA Technical Reports Server (NTRS)

Riley, , .

1994-01-01

The C Language Integrated Production System, CLIPS, is a shell for developing expert systems. It is designed to allow artificial intelligence research, development, and delivery on conventional computers. The primary design goals for CLIPS are portability, efficiency, and functionality. For these reasons, the program is written in C. CLIPS meets or outperforms most micro- and minicomputer based artificial intelligence tools. CLIPS is a forward chaining rule-based language. The program contains an inference engine and a language syntax that provide a framework for the construction of an expert system. It also includes tools for debugging an application. CLIPS is based on the Rete algorithm, which enables very efficient pattern matching. The collection of conditions and actions to be taken if the conditions are met is constructed into a rule network. As facts are asserted either prior to or during a session, CLIPS pattern-matches the number of fields. Wildcards and variables are supported for both single and multiple fields. CLIPS syntax allows the inclusion of externally defined functions (outside functions which are written in a language other than CLIPS). CLIPS itself can be embedded in a program such that the expert system is available as a simple subroutine call. Advanced features found in CLIPS version 4.3 include an integrated microEMACS editor, the ability to generate C source code from a CLIPS rule base to produce a dedicated executable, binary load and save capabilities for CLIPS rule bases, and the utility program CRSV (Cross-Reference, Style, and Verification) designed to facilitate the development and maintenance of large rule bases. Five machine versions are available. Each machine version includes the source and the executable for that machine. The UNIX version includes the source and binaries for IBM RS/6000, Sun3 series, and Sun4 series computers. The UNIX, DEC VAX, and DEC RISC Workstation versions are line oriented. The PC version and the Macintosh

Digital data, composite video multiplexer and demultiplexer boards for an IBM PC/AT compatible computer

NASA Technical Reports Server (NTRS)

Smith, Dean Lance

1993-01-01

Work continued on the design of two IBM PC/AT compatible computer interface boards. The boards will permit digital data to be transmitted over a composite video channel from the Orbiter. One board combines data with a composite video signal. The other board strips the data from the video signal.

IBM Demonstrates a General-Purpose, High-Performance, High-Availability Cloud-Hosted Data Distribution System With Live GOES-16 Weather Satellite Data

NASA Astrophysics Data System (ADS)

Snyder, P. L.; Brown, V. W.

2017-12-01

IBM has created a general purpose, data-agnostic solution that provides high performance, low data latency, high availability, scalability, and persistent access to the captured data, regardless of source or type. This capability is hosted on commercially available cloud environments and uses much faster, more efficient, reliable, and secure data transfer protocols than the more typically used FTP. The design incorporates completely redundant data paths at every level, including at the cloud data center level, in order to provide the highest assurance of data availability to the data consumers. IBM has been successful in building and testing a Proof of Concept instance on our IBM Cloud platform to receive and disseminate actual GOES-16 data as it is being downlinked. This solution leverages the inherent benefits of a cloud infrastructure configured and tuned for continuous, stable, high-speed data dissemination to data consumers worldwide at the downlink rate. It also is designed to ingest data from multiple simultaneous sources and disseminate data to multiple consumers. Nearly linear scalability is achieved by adding servers and storage.The IBM Proof of Concept system has been tested with our partners to achieve in excess of 5 Gigabits/second over public internet infrastructure. In tests with live GOES-16 data, the system routinely achieved 2.5 Gigabits/second pass-through to The Weather Company from the University of Wisconsin-Madison SSEC. Simulated data was also transferred from the Cooperative Institute for Climate and Satellites — North Carolina to The Weather Company, as well. The storage node allocated to our Proof of Concept system as tested was sized at 480 Terabytes of RAID protected disk as a worst case sizing to accommodate the data from four GOES-16 class satellites for 30 days in a circular buffer. This shows that an abundance of performance and capacity headroom exists in the IBM design that can be applied to additional missions.

Automated error correction in IBM quantum computer and explicit generalization

NASA Astrophysics Data System (ADS)

Ghosh, Debjit; Agarwal, Pratik; Pandey, Pratyush; Behera, Bikash K.; Panigrahi, Prasanta K.

2018-06-01

Construction of a fault-tolerant quantum computer remains a challenging problem due to unavoidable noise and fragile quantum states. However, this goal can be achieved by introducing quantum error-correcting codes. Here, we experimentally realize an automated error correction code and demonstrate the nondestructive discrimination of GHZ states in IBM 5-qubit quantum computer. After performing quantum state tomography, we obtain the experimental results with a high fidelity. Finally, we generalize the investigated code for maximally entangled n-qudit case, which could both detect and automatically correct any arbitrary phase-change error, or any phase-flip error, or any bit-flip error, or combined error of all types of error.

Homomorphic encryption experiments on IBM's cloud quantum computing platform

NASA Astrophysics Data System (ADS)

Huang, He-Liang; Zhao, You-Wei; Li, Tan; Li, Feng-Guang; Du, Yu-Tao; Fu, Xiang-Qun; Zhang, Shuo; Wang, Xiang; Bao, Wan-Su

2017-02-01

Quantum computing has undergone rapid development in recent years. Owing to limitations on scalability, personal quantum computers still seem slightly unrealistic in the near future. The first practical quantum computer for ordinary users is likely to be on the cloud. However, the adoption of cloud computing is possible only if security is ensured. Homomorphic encryption is a cryptographic protocol that allows computation to be performed on encrypted data without decrypting them, so it is well suited to cloud computing. Here, we first applied homomorphic encryption on IBM's cloud quantum computer platform. In our experiments, we successfully implemented a quantum algorithm for linear equations while protecting our privacy. This demonstration opens a feasible path to the next stage of development of cloud quantum information technology.

Program for Calculating the Cubic and Fifth Roots of a Number of Newton's Method (610 IBM Electronic Computer); PROGRAMMA PER IL CALCOLO DELLE RADICI TERZA E QUINTA DI UN NUMERO, COL METODO DI NEWTON (CALCOLATORE ELETTRONICO IBM 610)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Giucci, D.

1963-01-01

A program was devised for calculating the cubic and fifth roots of a number of Newton's method using the 610 IBM electronic computer. For convenience a program was added for obtaining n/sup th/ roots by the logarithmic method. (auth)

Linear circuit analysis program for IBM 1620 Monitor 2, 1311/1443 data processing system /CIRCS/

NASA Technical Reports Server (NTRS)

Hatfield, J.

1967-01-01

CIRCS is modification of IBSNAP Circuit Analysis Program, for use on smaller systems. This data processing system retains the basic dc, transient analysis, and FORTRAN 2 formats. It can be used on the IBM 1620/1311 Monitor I Mod 5 system, and solves a linear network containing 15 nodes and 45 branches.

LERC-SLAM - THE NASA LEWIS RESEARCH CENTER SATELLITE LINK ATTENUATION MODEL PROGRAM (IBM PC VERSION)

NASA Technical Reports Server (NTRS)

Manning, R. M.

1994-01-01

antenna required to establish a link with the satellite, the statistical parameters that characterize the rainrate process at the terminal site, the length of the propagation path within the potential rain region, and its projected length onto the local horizontal. The IBM PC version of LeRC-SLAM (LEW-14979) is written in Microsoft QuickBASIC for an IBM PC compatible computer with a monitor and printer capable of supporting an 80-column format. The IBM PC version is available on a 5.25 inch MS-DOS format diskette. The program requires about 30K RAM. The source code and executable are included. The Macintosh version of LeRC-SLAM (LEW-14977) is written in Microsoft Basic, Binary (b) v2.00 for Macintosh II series computers running MacOS. This version requires 400K RAM and is available on a 3.5 inch 800K Macintosh format diskette, which includes source code only. The Macintosh version was developed in 1987 and the IBM PC version was developed in 1989. IBM PC is a trademark of International Business Machines. MS-DOS is a registered trademark of Microsoft Corporation. Macintosh is a registered trademark of Apple Computer, Inc.

Artificial intelligence in neurodegenerative disease research: use of IBM Watson to identify additional RNA-binding proteins altered in amyotrophic lateral sclerosis.

PubMed

Bakkar, Nadine; Kovalik, Tina; Lorenzini, Ileana; Spangler, Scott; Lacoste, Alix; Sponaugle, Kyle; Ferrante, Philip; Argentinis, Elenee; Sattler, Rita; Bowser, Robert

2018-02-01

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with no effective treatments. Numerous RNA-binding proteins (RBPs) have been shown to be altered in ALS, with mutations in 11 RBPs causing familial forms of the disease, and 6 more RBPs showing abnormal expression/distribution in ALS albeit without any known mutations. RBP dysregulation is widely accepted as a contributing factor in ALS pathobiology. There are at least 1542 RBPs in the human genome; therefore, other unidentified RBPs may also be linked to the pathogenesis of ALS. We used IBM Watson ® to sieve through all RBPs in the genome and identify new RBPs linked to ALS (ALS-RBPs). IBM Watson extracted features from published literature to create semantic similarities and identify new connections between entities of interest. IBM Watson analyzed all published abstracts of previously known ALS-RBPs, and applied that text-based knowledge to all RBPs in the genome, ranking them by semantic similarity to the known set. We then validated the Watson top-ten-ranked RBPs at the protein and RNA levels in tissues from ALS and non-neurological disease controls, as well as in patient-derived induced pluripotent stem cells. 5 RBPs previously unlinked to ALS, hnRNPU, Syncrip, RBMS3, Caprin-1 and NUPL2, showed significant alterations in ALS compared to controls. Overall, we successfully used IBM Watson to help identify additional RBPs altered in ALS, highlighting the use of artificial intelligence tools to accelerate scientific discovery in ALS and possibly other complex neurological disorders.

IBM Watson Analytics: Automating Visualization, Descriptive, and Predictive Statistics

PubMed Central

2016-01-01

Background We live in an era of explosive data generation that will continue to grow and involve all industries. One of the results of this explosion is the need for newer and more efficient data analytics procedures. Traditionally, data analytics required a substantial background in statistics and computer science. In 2015, International Business Machines Corporation (IBM) released the IBM Watson Analytics (IBMWA) software that delivered advanced statistical procedures based on the Statistical Package for the Social Sciences (SPSS). The latest entry of Watson Analytics into the field of analytical software products provides users with enhanced functions that are not available in many existing programs. For example, Watson Analytics automatically analyzes datasets, examines data quality, and determines the optimal statistical approach. Users can request exploratory, predictive, and visual analytics. Using natural language processing (NLP), users are able to submit additional questions for analyses in a quick response format. This analytical package is available free to academic institutions (faculty and students) that plan to use the tools for noncommercial purposes. Objective To report the features of IBMWA and discuss how this software subjectively and objectively compares to other data mining programs. Methods The salient features of the IBMWA program were examined and compared with other common analytical platforms, using validated health datasets. Results Using a validated dataset, IBMWA delivered similar predictions compared with several commercial and open source data mining software applications. The visual analytics generated by IBMWA were similar to results from programs such as Microsoft Excel and Tableau Software. In addition, assistance with data preprocessing and data exploration was an inherent component of the IBMWA application. Sensitivity and specificity were not included in the IBMWA predictive analytics results, nor were odds ratios, confidence

IBM Watson Analytics: Automating Visualization, Descriptive, and Predictive Statistics.

PubMed

Hoyt, Robert Eugene; Snider, Dallas; Thompson, Carla; Mantravadi, Sarita

2016-10-11

We live in an era of explosive data generation that will continue to grow and involve all industries. One of the results of this explosion is the need for newer and more efficient data analytics procedures. Traditionally, data analytics required a substantial background in statistics and computer science. In 2015, International Business Machines Corporation (IBM) released the IBM Watson Analytics (IBMWA) software that delivered advanced statistical procedures based on the Statistical Package for the Social Sciences (SPSS). The latest entry of Watson Analytics into the field of analytical software products provides users with enhanced functions that are not available in many existing programs. For example, Watson Analytics automatically analyzes datasets, examines data quality, and determines the optimal statistical approach. Users can request exploratory, predictive, and visual analytics. Using natural language processing (NLP), users are able to submit additional questions for analyses in a quick response format. This analytical package is available free to academic institutions (faculty and students) that plan to use the tools for noncommercial purposes. To report the features of IBMWA and discuss how this software subjectively and objectively compares to other data mining programs. The salient features of the IBMWA program were examined and compared with other common analytical platforms, using validated health datasets. Using a validated dataset, IBMWA delivered similar predictions compared with several commercial and open source data mining software applications. The visual analytics generated by IBMWA were similar to results from programs such as Microsoft Excel and Tableau Software. In addition, assistance with data preprocessing and data exploration was an inherent component of the IBMWA application. Sensitivity and specificity were not included in the IBMWA predictive analytics results, nor were odds ratios, confidence intervals, or a confusion matrix

Development of a GIFTS (Graphics-Oriented Interactive Finite-Element Time-Sharing System) Plotting Package Compatible with Either PLOT10 or IBM/DSM Graphics.

DTIC Science & Technology

1983-06-01

1D-A132 95 DEVELOPMENT OF A GIFTS (GRAPHICS ORIENTED INTERACTIVE i/i FINITE-ELEMENT TIME..(U) NAVAL POSTGRADUATE SCHOOL I MONTEREY CA T R PICKLES JUN...183 THESIS " DEVELOPMENT OF A GIFTS PLOTTING PACKAGE COMPATIBLE WITH EITHER PLOT10 OR IBM/DSM GRAPHICS by Thomas R. Pickles June 1983 Thesis Advisor: G...TYPEAFtWEPORT & PERIOD COVERED Development of GIFTS Plotting Package Bi ’s Thesis; Compatible with either PLOTl0 or June 1983 IBM/DSM Graphics 6. PERFORMING ORO

SFAP: Scan-Tron Forms Analysis Package for the IBM-PC. User's Guide, Version 2.0.

ERIC Educational Resources Information Center

Harnisch, Delwyn L.; And Others

The Scan-Tron Forms Analysis Package (SFAP) is a collection of integrated programs that allow an IBM-PC (or compatible) to collect data from a Scan-Tron 1200 forms reader. In addition to the basic data acquisition capability, the SFAP has additional capabilities related to the viewing and formatting of incoming data. When used in combination with…

POLUTE; forest air pollutant uptake model. [IBM360,370; CSMP

DOE Office of Scientific and Technical Information (OSTI.GOV)

Murphy, C.E.

POLUTE is a computer model designed to estimate the uptake of air pollutants by forests. The model utilizes submodels to describe atmospheric diffusion immediately above and within the canopy, and into the sink areas within or on the trees. The program implementing the model is general and can be used, with only minor changes, for any gaseous pollutant. The model provides an estimate describing the response of the vegetarian-atmosphere system to the environment as related to three types of processes: atmospheric diffusion, diffusion near and inside the absorbing plant, and the physical and chemical processes at the sink on ormore » within the plant.IBM360,370; CSMP; OS/370.« less

Engineering PFLOTRAN for Scalable Performance on Cray XT and IBM BlueGene Architectures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mills, Richard T; Sripathi, Vamsi K; Mahinthakumar, Gnanamanika

We describe PFLOTRAN - a code for simulation of coupled hydro-thermal-chemical processes in variably saturated, non-isothermal, porous media - and the approaches we have employed to obtain scalable performance on some of the largest scale supercomputers in the world. We present detailed analyses of I/O and solver performance on Jaguar, the Cray XT5 at Oak Ridge National Laboratory, and Intrepid, the IBM BlueGene/P at Argonne National Laboratory, that have guided our choice of algorithms.

Variable viscosity and density biofilm simulations using an immersed boundary method, part II: Experimental validation and the heterogeneous rheology-IBM

NASA Astrophysics Data System (ADS)

Stotsky, Jay A.; Hammond, Jason F.; Pavlovsky, Leonid; Stewart, Elizabeth J.; Younger, John G.; Solomon, Michael J.; Bortz, David M.

2016-07-01

The goal of this work is to develop a numerical simulation that accurately captures the biomechanical response of bacterial biofilms and their associated extracellular matrix (ECM). In this, the second of a two-part effort, the primary focus is on formally presenting the heterogeneous rheology Immersed Boundary Method (hrIBM) and validating our model by comparison to experimental results. With this extension of the Immersed Boundary Method (IBM), we use the techniques originally developed in Part I ([19]) to treat biofilms as viscoelastic fluids possessing variable rheological properties anchored to a set of moving locations (i.e., the bacteria locations). In particular, we incorporate spatially continuous variable viscosity and density fields into our model. Although in [14,15], variable viscosity is used in an IBM context to model discrete viscosity changes across interfaces, to our knowledge this work and Part I are the first to apply the IBM to model a continuously variable viscosity field. We validate our modeling approach from Part I by comparing dynamic moduli and compliance moduli computed from our model to data from mechanical characterization experiments on Staphylococcus epidermidis biofilms. The experimental setup is described in [26] in which biofilms are grown and tested in a parallel plate rheometer. In order to initialize the positions of bacteria in the biofilm, experimentally obtained three dimensional coordinate data was used. One of the major conclusions of this effort is that treating the spring-like connections between bacteria as Maxwell or Zener elements provides good agreement with the mechanical characterization data. We also found that initializing the simulations with different coordinate data sets only led to small changes in the mechanical characterization results. Matlab code used to produce results in this paper will be available at https://github.com/MathBioCU/BiofilmSim.

A materials accounting system for an IBM PC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bearse, R.C.; Thomas, R.J.; Henslee, S.P.

1986-01-01

The authors have adapted the Los Alamos MASS accounting system for use on an IBM PC/AT at the Fuels Manufacturing Facility (FMF) at Argonne National Laboratory West (ANL-WEST). Cost of hardware and proprietary software was less than $10,000 per station. The system consists of three stations between which accounting information is transferred using floppy disks accompanying special nuclear material shipments. The programs were implemented in dBASEIII and were compiled using the proprietary software CLIPPER. Modifications to the inventory can be posted in just a few minutes, and operator/computer interaction is nearly instantaneous. After the records are built by the user,more » it takes 4-5 seconds to post the results to the database files. A version of this system was specially adapted and is currently in use at the FMF facility at Argonne National Laboratory. Initial satisfaction is adequate and software and hardware problems are minimal.« less

Ada Compiler Validation Summary Report: Certificate Number: 890420W1. 10074 International Business Machines Corporation, IBM Development System for the Ada Language MVS Ada Compiler, Version 2.1.1 IBM 4381 (Host and Target)

DTIC Science & Technology

1989-04-20

20. ARS1AAI . (Contimne on reverse side olnetessary *rwenPtif) by bfoci nur~be’) International Business Machines Corporation, IBM Development System...Number: AVF-VSR-261.0789 89-01-26-TEL Ada COMPILER VALIDATION SUMMARY REPORT: Certificate Number: 890420W1.10074 International Business Machines...computer. The compiler was tested using command scripts provided by International Business Machines Corporation and reviewed by the validation team. The

Physical realization of topological quantum walks on IBM-Q and beyond

NASA Astrophysics Data System (ADS)

Balu, Radhakrishnan; Castillo, Daniel; Siopsis, George

2018-07-01

We discuss an efficient physical realization of topological quantum walks on a one-dimensional finite lattice with periodic boundary conditions (circle). The N-point lattice is realized with {log}}2N qubits, and the quantum circuit utilizes a number of quantum gates that are polynomial in the number of qubits. In a certain scaling limit, we show that a large number of steps are implemented with a number of quantum gates which are independent of the number of steps. We ran the quantum algorithm on the IBM-Q five-qubit quantum computer, thus experimentally demonstrating topological features, such as boundary bound states, on a one-dimensional lattice with N = 4 points.

IBM-2 calculation with configuration mixing for Ge isotopes

NASA Astrophysics Data System (ADS)

Padilla-Rodal, Elizabeth; Galindo-Uribarri, Alfredo

2005-04-01

Recent results on Coulomb excitation experiments of radioactive neutron-rich Ge isotopes at the Holifield Radioactive Ion Beam Facility allow the study of the systematic trend of B(E2; 0^+ ->2^+) between the sub-shell closures at N=40 and the N=50 [1]. The new information on the E2 transition strengths constitutes a stringent test for the nuclear models and has motivated us to revisit the use of Interacting Boson Model in this region. We show that the IBM-2 with configuration mixing is a successful model to describe the shape transition phenomena that take place around N=40 in stable germanium isotopes, as well as the predictions given by this model about the evolution of the structure for the radioactive ^78, 80, 82Ge nuclei. [1] E. Padilla-Rodal Ph.D. Thesis UNAM; submitted for publication.

Conversion of the Aerodynamic Preliminary Analysis System (APAS) to an IBM PC Compatible Format

NASA Technical Reports Server (NTRS)

Kruep, John M.

1995-01-01

The conversion of the Aerodynamic Preliminary Analysis System (APAS) software from a Silicon Graphics UNIX-based platform to a DOS-based IBM PC compatible is discussed. Relevant background information is given, followed by a discussion of the steps taken to accomplish the conversion and a discussion of the type of problems encountered during the conversion. A brief comparison of aerodynamic data obtained using APAS with data from another source is also made.

An Amphibious Ship-To-Shore Simulation for Use on an IBM PC (Personal Computer)

DTIC Science & Technology

1984-09-01

CA : «< <- j Special ■ *- amphibious ship- an IBM Personal ion of the phy- he logic used analysis, and a DD | JAM 11 1473 COITION...research, for instance, wiL1 be geared toward a technically oriented person who is familiar with computers, programming and the associated logic. A...problem, often vaguely stated by the decision aaker , into precise and operational terms [Ref. Hz p.51]. The analysis begins with specification of the

The Top Six Compatibles: A Closer Look at the Machines That Are Most Compatible with the IBM PC.

ERIC Educational Resources Information Center

McMullen, Barbara E.; And Others

1984-01-01

Reviews six operationally compatible microcomputers that are most able to run IBM software without modifications--Compaq, Columbia, Corona, Hyperion, Eagle PC, and Chameleon. Information given for each includes manufacturer, uses, standard features, base list price, typical system price, and options and accessories. (MBR)

Computer program for the IBM personal computer which searches for approximate matches to short oligonucleotide sequences in long target DNA sequences.

PubMed Central

Myers, E W; Mount, D W

1986-01-01

We describe a program which may be used to find approximate matches to a short predefined DNA sequence in a larger target DNA sequence. The program predicts the usefulness of specific DNA probes and sequencing primers and finds nearly identical sequences that might represent the same regulatory signal. The program is written in the C programming language and will run on virtually any computer system with a C compiler, such as the IBM/PC and other computers running under the MS/DOS and UNIX operating systems. The program has been integrated into an existing software package for the IBM personal computer (see article by Mount and Conrad, this volume). Some examples of its use are given. PMID:3753785

CD-ROM source data uploaded to the operating and storage devices of an IBM 3090 mainframe through a PC terminal.

PubMed

Boros, L G; Lepow, C; Ruland, F; Starbuck, V; Jones, S; Flancbaum, L; Townsend, M C

1992-07-01

A powerful method of processing MEDLINE and CINAHL source data uploaded to the IBM 3090 mainframe computer through an IBM/PC is described. Data are first downloaded from the CD-ROM's PC devices to floppy disks. These disks then are uploaded to the mainframe computer through an IBM/PC equipped with WordPerfect text editor and computer network connection (SONNGATE). Before downloading, keywords specifying the information to be accessed are typed at the FIND prompt of the CD-ROM station. The resulting abstracts are downloaded into a file called DOWNLOAD.DOC. The floppy disks containing the information are simply carried to an IBM/PC which has a terminal emulation (TELNET) connection to the university-wide computer network (SONNET) at the Ohio State University Academic Computing Services (OSU ACS). The WordPerfect (5.1) processes and saves the text into DOS format. Using the File Transfer Protocol (FTP, 130,000 bytes/s) of SONNET, the entire text containing the information obtained through the MEDLINE and CINAHL search is transferred to the remote mainframe computer for further processing. At this point, abstracts in the specified area are ready for immediate access and multiple retrieval by any PC having network switch or dial-in connection after the USER ID, PASSWORD and ACCOUNT NUMBER are specified by the user. The system provides the user an on-line, very powerful and quick method of searching for words specifying: diseases, agents, experimental methods, animals, authors, and journals in the research area downloaded. The user can also copy the TItles, AUthors and SOurce with optional parts of abstracts into papers under edition. This arrangement serves the special demands of a research laboratory by handling MEDLINE and CINAHL source data resulting after a search is performed with keywords specified for ongoing projects. Since the Ohio State University has a centrally founded mainframe system, the data upload, storage and mainframe operations are free.

Cell-NPE (Numerical Performance Evaluation): Programming the IBM Cell Broadband Engine -- A General Parallelization Strategy

DTIC Science & Technology

2008-04-01

Space GmbH as follows: B. TECHNICAL PRPOPOSA/DESCRIPTION OF WORK Cell: A Revolutionary High Performance Computing Platform On 29 June 2005 [1...IBM has announced that is has partnered with Mercury Computer Systems, a maker of specialized computers . The Cell chip provides massive floating-point...the computing industry away from the traditional processor technology dominated by Intel. While in the past, the development of computing power has

Performance of OVERFLOW-D Applications based on Hybrid and MPI Paradigms on IBM Power4 System

NASA Technical Reports Server (NTRS)

Djomehri, M. Jahed; Biegel, Bryan (Technical Monitor)

2002-01-01

This report briefly discusses our preliminary performance experiments with parallel versions of OVERFLOW-D applications. These applications are based on MPI and hybrid paradigms on the IBM Power4 system here at the NAS Division. This work is part of an effort to determine the suitability of the system and its parallel libraries (MPI/OpenMP) for specific scientific computing objectives.

A Structured Microprogram Set for the SUMC Computer to Emulate the IBM System/360, Model 50

NASA Technical Reports Server (NTRS)

Gimenez, Cesar R.

1975-01-01

Similarities between regular and structured microprogramming were examined. An explanation of machine branching architecture (particularly in the SUMC computer), required for ease of structured microprogram implementation is presented. Implementation of a structured microprogram set in the SUMC to emulate the IBM System/360 is described and a comparison is made between the structured set with a nonstructured set previously written for the SUMC.

Clinical aspects of the Mayo/IBM PACS project

NASA Astrophysics Data System (ADS)

Forbes, Glenn S.; Morin, Richard L.; Pavlicek, William

1991-07-01

A joint project between Mayo Clinic and IBM to develop a picture archival and communications system has been under development for three years. This project began as a potential solution to a pressing archival problem in magnetic resonance imaging. The project has grown to encompass a much larger sphere of activity including workstations, image retrieval, and report archival. This report focuses on the clinical aspects involved in the design, development, and implementation of such a system. In particular, emphasis is placed on the clinical impact of the system both inside and outside of the radiology department. The primary concerns have centered on fidelity of archival data, ease of use, and diagnostic efficacy. The project to date has been limited to neuroradiology practice. This group consists of nine staff radiologists and fellows. Administrative policy decisions regarding the accessibility and available of digital data in the clinical environment have been much more difficult and complex than originally conceived. Based on the observations thus far, the authors believe the system will become a useful and valuable adjunct to clinical practice of radiology.

A Comparison of Two Panasonic Lithium-Ion Batteries and Cells for the IBM Thinkpad

NASA Technical Reports Server (NTRS)

Jeevarajan, Judith A.; Cook, Joseph S.; Davies, Francis J.; Collins, Jacob; Bragg, Bobby J.

2003-01-01

The IBM Thinkpad 760XD has been used in the Orbiter and International Space Station since 2000. The Thinkpad is powered by a Panasonic Li-ion battery that has a voltage of 10.8 V and 3.0 Ah capacity. This Thinkpad is now being replaced by the IBM Thinkpad A31P which has a Panasonic Li-ion battery that has a voltage of 10.8 V and 4.0 Ah capacity. Both batteries have protective circuit boards. The Panasonic battery for the Thinkpad 760XD had 12 Panasonic 17500 cells of 0.75 Ah capacity in a 4P3S cOnfiguration. The new Panasonic battery has 6 Panasonic 18650 cells of 2.0 Ah capacity in a 2P3S configuration. The batteries and cells for both models have been evaluated for performance and safety. A comparison of the cells under similar test conditions will be presented. The performance of the cells has been evaluated under different rates of charge and discharge and different temperatures. The cells have been tested under abuse conditions and the safety features in the cells evaluated. The protective circuit board in the battery was also tested under conditions of overcharge, overdischarge, short circuit and unbalanced cell configurations. The results of the studies will be presented in this paper.

Gyrokinetic micro-turbulence simulations on the NERSC 16-way SMP IBM SP computer: experiences and performance results

NASA Astrophysics Data System (ADS)

Ethier, Stephane; Lin, Zhihong

2001-10-01

Earlier this year, the National Energy Research Scientific Computing center (NERSC) took delivery of the second most powerful computer in the world. With its 2,528 processors running at a peak performance of 1.5 GFlops, this IBM SP machine has a theoretical performance of almost 3.8 TFlops. To efficiently harness such computing power in one single code is not an easy task and requires a good knowledge of the computer's architecture. Here we present the steps that we followed to improve our gyrokinetic micro-turbulence code GTC in order to take advantage of the new 16-way shared memory nodes of the NERSC IBM SP. Performance results are shown as well as details about the improved mixed-mode MPI-OpenMP model that we use. The enhancements to the code allowed us to tackle much bigger problem sizes, getting closer to our goal of simulating an ITER-size tokamak with both kinetic ions and electrons.(This work is supported by DOE Contract No. DE-AC02-76CH03073 (PPPL), and in part by the DOE Fusion SciDAC Project.)

JSD: Parallel Job Accounting on the IBM SP2

NASA Technical Reports Server (NTRS)

Saphir, William; Jones, James Patton; Walter, Howard (Technical Monitor)

1995-01-01

The IBM SP2 is one of the most promising parallel computers for scientific supercomputing - it is fast and usually reliable. One of its biggest problems is a lack of robust and comprehensive system software. Among other things, this software allows a collection of Unix processes to be treated as a single parallel application. It does not, however, provide accounting for parallel jobs other than what is provided by AIX for the individual process components. Without parallel job accounting, it is not possible to monitor system use, measure the effectiveness of system administration strategies, or identify system bottlenecks. To address this problem, we have written jsd, a daemon that collects accounting data for parallel jobs. jsd records information in a format that is easily machine- and human-readable, allowing us to extract the most important accounting information with very little effort. jsd also notifies system administrators in certain cases of system failure.

Deep learning for medical image segmentation - using the IBM TrueNorth neurosynaptic system

NASA Astrophysics Data System (ADS)

Moran, Steven; Gaonkar, Bilwaj; Whitehead, William; Wolk, Aidan; Macyszyn, Luke; Iyer, Subramanian S.

2018-03-01

Deep convolutional neural networks have found success in semantic image segmentation tasks in computer vision and medical imaging. These algorithms are executed on conventional von Neumann processor architectures or GPUs. This is suboptimal. Neuromorphic processors that replicate the structure of the brain are better-suited to train and execute deep learning models for image segmentation by relying on massively-parallel processing. However, given that they closely emulate the human brain, on-chip hardware and digital memory limitations also constrain them. Adapting deep learning models to execute image segmentation tasks on such chips, requires specialized training and validation. In this work, we demonstrate for the first-time, spinal image segmentation performed using a deep learning network implemented on neuromorphic hardware of the IBM TrueNorth Neurosynaptic System and validate the performance of our network by comparing it to human-generated segmentations of spinal vertebrae and disks. To achieve this on neuromorphic hardware, the training model constrains the coefficients of individual neurons to {-1,0,1} using the Energy Efficient Deep Neuromorphic (EEDN)1 networks training algorithm. Given the 1 million neurons and 256 million synapses, the scale and size of the neural network implemented by the IBM TrueNorth allows us to execute the requisite mapping between segmented images and non-uniform intensity MR images >20 times faster than on a GPU-accelerated network and using <0.1 W. This speed and efficiency implies that a trained neuromorphic chip can be deployed in intra-operative environments where real-time medical image segmentation is necessary.

An IBM-3 analysis of the nuclei just beyond the magic numbers N = Z = 28

NASA Astrophysics Data System (ADS)

Elliott, J. P.; Evans, J. A.; Lac, V. S.; Long, G. L.

1996-02-01

The isospin-invariant form IBM-3 of the interacting boson model has been used to study energies and electromagnetic properties of the isotopes of nickel, zinc, germanium and selenium in the first half of the 1p {3}/{2}, 0f {5}/{2} and 1p {1}/{2} shell. The hamiltonian and electromagnetic operators vary with boson number and isospin in a manner determined by a mapping into the shell-model based on seniority and reduced isospin.

EMERALD REVISION 1; PWR accident activity release. [IBM360,370; FORTRAN IV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fowler, T.B.; Tobias, M.L.; Fox, J.N.

The EMERALD program is designed for the calculation of radiation releases and exposures resulting from abnormal operation of a large pressurized water reactor (PWR). The approach used in EMERALD is similar to an analog simulation of a real system. Each component or volume in the plant which contains a radioactive material is represented by a subroutine which keeps track of the production, transfer, decay and absorption of radioactivity in that volume. During the course of the analysis of an accident, activity is transferred from subroutine to subroutine in the program as it would be transferred from place to place inmore » the plant. For example, in the calculation of the doses resulting from a loss-of-coolant accident the program first calculates the activity built up in the fuel before the accident, then releases some of this activity to the containment volume. Some of this activity is then released to the atmosphere. The rates of transfer, leakage, production, cleanup, decay, and release are read in as input to the program. Subroutines are also included which calculate the on-site and off-site radiation exposures at various distances for individual isotopes and sums of isotopes. The program contains a library of physical data for the twenty-five isotopes of most interest in licensing calculations, and other isotopes can be added or substituted. Because of the flexible nature of the simulation approach, the EMERALD program can be used for most calculations involving the production and release of radioactive materials during abnormal operation of a PWR. These include design, operational, and licensing studies.IBM360,370; FORTRAN IV; OS/360,370 (IBM360,370); 520K bytes of memory are required..« less

NASTRAN data generation of helicopter fuselages using interactive graphics. [preprocessor system for finite element analysis using IBM computer

NASA Technical Reports Server (NTRS)

Sainsbury-Carter, J. B.; Conaway, J. H.

1973-01-01

The development and implementation of a preprocessor system for the finite element analysis of helicopter fuselages is described. The system utilizes interactive graphics for the generation, display, and editing of NASTRAN data for fuselage models. It is operated from an IBM 2250 cathode ray tube (CRT) console driven by an IBM 370/145 computer. Real time interaction plus automatic data generation reduces the nominal 6 to 10 week time for manual generation and checking of data to a few days. The interactive graphics system consists of a series of satellite programs operated from a central NASTRAN Systems Monitor. Fuselage structural models including the outer shell and internal structure may be rapidly generated. All numbering systems are automatically assigned. Hard copy plots of the model labeled with GRID or elements ID's are also available. General purpose programs for displaying and editing NASTRAN data are included in the system. Utilization of the NASTRAN interactive graphics system has made possible the multiple finite element analysis of complex helicopter fuselage structures within design schedules.

The Efficiency and the Scalability of an Explicit Operator on an IBM POWER4 System

NASA Technical Reports Server (NTRS)

Frumkin, Michael; Biegel, Bryan A. (Technical Monitor)

2002-01-01

We present an evaluation of the efficiency and the scalability of an explicit CFD operator on an IBM POWER4 system. The POWER4 architecture exhibits a common trend in HPC architectures: boosting CPU processing power by increasing the number of functional units, while hiding the latency of memory access by increasing the depth of the memory hierarchy. The overall machine performance depends on the ability of the caches-buses-fabric-memory to feed the functional units with the data to be processed. In this study we evaluate the efficiency and scalability of one explicit CFD operator on an IBM POWER4. This operator performs computations at the points of a Cartesian grid and involves a few dozen floating point numbers and on the order of 100 floating point operations per grid point. The computations in all grid points are independent. Specifically, we estimate the efficiency of the RHS operator (SP of NPB) on a single processor as the observed/peak performance ratio. Then we estimate the scalability of the operator on a single chip (2 CPUs), a single MCM (8 CPUs), 16 CPUs, and the whole machine (32 CPUs). Then we perform the same measurements for a chache-optimized version of the RHS operator. For our measurements we use the HPM (Hardware Performance Monitor) counters available on the POWER4. These counters allow us to analyze the obtained performance results.

The genetic basis of flecking and its relationship to disease resistance in the IBM maize mapping population.

PubMed

Vontimitta, Vijay; Olukolu, Bode A; Penning, Bryan W; Johal, Gurmukh; Balint-Kurti, P J

2015-11-01

In this paper, we determine the genetic architecture controlling leaf flecking in maize and investigate its relationship to disease resistance and the defense response. Flecking is defined as a mild, often environmentally dependent lesion phenotype observed on the leaves of several commonly used maize inbred lines. Anecdotal evidence suggests a link between flecking and enhanced broad-spectrum disease resistance. Neither the genetic basis underlying flecking nor its possible relationship to disease resistance has been systematically evaluated. The commonly used maize inbred Mo17 has a mild flecking phenotype. The IBM-advanced intercross mapping population, derived from a cross between Mo17 and another commonly used inbred B73, has been used for mapping a number of traits in maize including several related to disease resistance. In this study, flecking was assessed in the IBM population over 6 environments. Several quantitative trait loci for flecking were identified, with the strongest one located on chromosome 6. Low but moderately significant correlations were observed between stronger flecking and higher disease resistance with respect to two diseases, southern leaf blight and northern leaf blight and between stronger flecking and a stronger defense response.

IBM's Health Analytics and Clinical Decision Support.

PubMed

Kohn, M S; Sun, J; Knoop, S; Shabo, A; Carmeli, B; Sow, D; Syed-Mahmood, T; Rapp, W

2014-08-15

This survey explores the role of big data and health analytics developed by IBM in supporting the transformation of healthcare by augmenting evidence-based decision-making. Some problems in healthcare and strategies for change are described. It is argued that change requires better decisions, which, in turn, require better use of the many kinds of healthcare information. Analytic resources that address each of the information challenges are described. Examples of the role of each of the resources are given. There are powerful analytic tools that utilize the various kinds of big data in healthcare to help clinicians make more personalized, evidenced-based decisions. Such resources can extract relevant information and provide insights that clinicians can use to make evidence-supported decisions. There are early suggestions that these resources have clinical value. As with all analytic tools, they are limited by the amount and quality of data. Big data is an inevitable part of the future of healthcare. There is a compelling need to manage and use big data to make better decisions to support the transformation of healthcare to the personalized, evidence-supported model of the future. Cognitive computing resources are necessary to manage the challenges in employing big data in healthcare. Such tools have been and are being developed. The analytic resources, themselves, do not drive, but support healthcare transformation.

Impacts of the IBM Cell Processor to Support Climate Models

NASA Technical Reports Server (NTRS)

Zhou, Shujia; Duffy, Daniel; Clune, Tom; Suarez, Max; Williams, Samuel; Halem, Milt

2008-01-01

NASA is interested in the performance and cost benefits for adapting its applications to the IBM Cell processor. However, its 256KB local memory per SPE and the new communication mechanism, make it very challenging to port an application. We selected the solar radiation component of the NASA GEOS-5 climate model, which: (1) is representative of column physics (approximately 50% computational time), (2) has a high computational load relative to transferring data from and to main memory, (3) performs independent calculations across multiple columns. We converted the baseline code (single-precision, Fortran) to C and ported it with manually SIMDizing 4 independent columns and found that a Cell with 8 SPEs can process 2274 columns per second. Compared with the baseline results, the Cell is approximately 5.2X, approximately 8.2X, approximately 15.1X faster than a core on Intel Woodcrest, Dempsey, and Itanium2, respectively. We believe this dramatic performance improvement makes a hybrid cluster with Cell and traditional nodes competitive.

NACA Computer Operates an IBM Telereader

NASA Image and Video Library

1952-02-21

A staff member from the Computing Section at the National Advisory Committee for Aeronautics (NACA) Lewis Flight Propulsion Laboratory operates an International Business Machines (IBM) telereader at the 8- by 6-Foot Supersonic Wind Tunnel. The telereader was used to measure recorded data from motion picture film or oscillographs. The machine could perform 50 measurements per minute. The component to her right is a telerecordex that was used convert the telereader measurements into decimal form and record the data on computer punch cards. During test runs in the 8- by 6-foot tunnel, or the other large test facilities, pressure sensors on the test article were connected to mercury-filled manometer tubes located below the test section. The mercury would rise or fall in relation to the pressure fluctuations in the test section. Initially, female staff members, known as “computers,” transcribed all the measurements by hand. The process became automated with the introduction of the telereader and other data reduction equipment in the early 1950s. The Computer Section staff members were still needed to operate the machines. The Computing Section was introduced during World War II to relieve short-handed research engineers of some of the tedious work. The computers made the initial computations and plotted the data graphically. The researcher then analyzed the data and either summarized the findings in a report or made modifications or ran the test again. The computers and analysts were located in the Altitude Wind Tunnel Shop and Office Building office wing during the 1940s. They were transferred to the new facility when the 8- by 6-Foot tunnel began operations in 1948.

Effect of system workload on operating system reliability - A study on IBM 3081

NASA Technical Reports Server (NTRS)

Iyer, R. K.; Rossetti, D. J.

1985-01-01

This paper presents an analysis of operating system failures on an IBM 3081 running VM/SP. Three broad categories of software failures are found: error handling, program control or logic, and hardware related; it is found that more than 25 percent of software failures occur in the hardware/software interface. Measurements show that results on software reliability cannot be considered representative unless the system workload is taken into account. The overall CPU execution rate, although measured to be close to 100 percent most of the time, is not found to correlate strongly with the occurrence of failures. Possible reasons for the observed workload failure dependency, based on detailed investigations of the failure data, are discussed.

Investigation of the Effect of Assignment Projects on Mathematical Activity of Graduating Junior High School Students.

ERIC Educational Resources Information Center

Zehavi, Nurit

This study explored student mathematical activity in open problem-solving situations, derived from the work of Polya on problem solving and Skemp on intelligent learning and teaching. Assignment projects with problems for ninth-grade students were developed, whether they elicit the desired cognitive and cogno-affective goals was investigated, and…

PREVAIL: IBM's e-beam technology for next generation lithography

NASA Astrophysics Data System (ADS)

Pfeiffer, Hans C.

2000-07-01

PREVAIL - Projection Reduction Exposure with Variable Axis Immersion Lenses represents the high throughput e-beam projection approach to NGL which IBM is pursuing in cooperation with Nikon Corporation as alliance partner. This paper discusses the challenges and accomplishments of the PREVAIL project. The supreme challenge facing all e-beam lithography approaches has been and still is throughput. Since the throughput of e-beam projection systems is severely limited by the available optical field size, the key to success is the ability to overcome this limitation. The PREVAIL technique overcomes field-limiting off-axis aberrations through the use of variable axis lenses, which electronically shift the optical axis simultaneously with the deflected beam so that the beam effectively remains on axis. The resist images obtained with the Proof-of-Concept (POC) system demonstrate that PREVAIL effectively eliminates off- axis aberrations affecting both resolution and placement accuracy of pixels. As part of the POC system a high emittance gun has been developed to provide uniform illumination of the patterned subfield and to fill the large numerical aperture projection optics designed to significantly reduce beam blur caused by Coulomb interaction.

COMPPAP - COMPOSITE PLATE BUCKLING ANALYSIS PROGRAM (IBM PC VERSION)

NASA Technical Reports Server (NTRS)

Smith, J. P.

1994-01-01

The Composite Plate Buckling Analysis Program (COMPPAP) was written to help engineers determine buckling loads of orthotropic (or isotropic) irregularly shaped plates without requiring hand calculations from design curves or extensive finite element modeling. COMPPAP is a one element finite element program that utilizes high-order displacement functions. The high order of the displacement functions enables the user to produce results more accurate than traditional h-finite elements. This program uses these high-order displacement functions to perform a plane stress analysis of a general plate followed by a buckling calculation based on the stresses found in the plane stress solution. The current version assumes a flat plate (constant thickness) subject to a constant edge load (normal or shear) on one or more edges. COMPPAP uses the power method to find the eigenvalues of the buckling problem. The power method provides an efficient solution when only one eigenvalue is desired. Once the eigenvalue is found, the eigenvector, which corresponds to the plate buckling mode shape, results as a by-product. A positive feature of the power method is that the dominant eigenvalue is the first found, which is this case is the plate buckling load. The reported eigenvalue expresses a load factor to induce plate buckling. COMPPAP is written in ANSI FORTRAN 77. Two machine versions are available from COSMIC: a PC version (MSC-22428), which is for IBM PC 386 series and higher computers and compatibles running MS-DOS; and a UNIX version (MSC-22286). The distribution medium for both machine versions includes source code for both single and double precision versions of COMPPAP. The PC version includes source code which has been optimized for implementation within DOS memory constraints as well as sample executables for both the single and double precision versions of COMPPAP. The double precision versions of COMPPAP have been successfully implemented on an IBM PC 386 compatible running

Earth Observations Division version of the Laboratory for Applications of Remote Sensing System (EOD-LARSYS) user guide for the IBM 370/148. Volume 2: User reference manual

NASA Technical Reports Server (NTRS)

Aucoin, P. J.; Stewart, J.; Mckay, M. F. (Principal Investigator)

1980-01-01

This document presents instructions for analysts who use the EOD-LARSYS as programmed on the Purdue University IBM 370/148 (recently replaced by the IBM 3031) computer. It presents sample applications, control cards, and error messages for all processors in the system and gives detailed descriptions of the mathematical procedures and information needed to execute the system and obtain the desired output. EOD-LARSYS is the JSC version of an integrated batch system for analysis of multispectral scanner imagery data. The data included is designed for use with the as built documentation (volume 3) and the program listings (volume 4). The system is operational from remote terminals at Johnson Space Center under the virtual machine/conversational monitor system environment.

Improved programs for DNA and protein sequence analysis on the IBM personal computer and other standard computer systems.

PubMed Central

Mount, D W; Conrad, B

1986-01-01

We have previously described programs for a variety of types of sequence analysis (1-4). These programs have now been integrated into a single package. They are written in the standard C programming language and run on virtually any computer system with a C compiler, such as the IBM/PC and other computers running under the MS/DOS and UNIX operating systems. The programs are widely distributed and may be obtained from the authors as described below. PMID:3753780

Proceedings of the IBM Academic Information Systems University AEP Conference: "Tools for Learning" (2nd, San Diego, California, April 5-8, 1986).

ERIC Educational Resources Information Center

Dwyer, Frederick D., Ed.

Advanced Education Projects (AEPs) are a series of multidisciplinary, advanced experiments in educational computing supported by IBM and currently in progress at 19 leading universities. Each AEP has established a series of curricular experiments to explore the use of workstations and network technologies as part of the instructional process. The…

Analyzing checkpointing trends for applications on the IBM Blue Gene/P system.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Naik, H.; Gupta, R.; Beckman, P.

Current petascale systems have tens of thousands of hardware components and complex system software stacks, which increase the probability of faults occurring during the lifetime of a process. Checkpointing has been a popular method of providing fault tolerance in high-end systems. While considerable research has been done to optimize checkpointing, in practice the method still involves a high-cost overhead for users. In this paper, we study the checkpointing overhead seen by applications running on leadership-class machines such as the IBM Blue Gene/P at Argonne National Laboratory. We study various applications and design a methodology to assist users in understanding andmore » choosing checkpointing frequency and reducing the overhead incurred. In particular, we study three popular applications -- the Grid-Based Projector-Augmented Wave application, the Carr-Parrinello Molecular Dynamics application, and a Nek5000 computational fluid dynamics application -- and analyze their memory usage and possible checkpointing trends on 32,768 processors of the Blue Gene/P system.« less

OpenZika: An IBM World Community Grid Project to Accelerate Zika Virus Drug Discovery.

PubMed

Ekins, Sean; Perryman, Alexander L; Horta Andrade, Carolina

2016-10-01

The Zika virus outbreak in the Americas has caused global concern. To help accelerate this fight against Zika, we launched the OpenZika project. OpenZika is an IBM World Community Grid Project that uses distributed computing on millions of computers and Android devices to run docking experiments, in order to dock tens of millions of drug-like compounds against crystal structures and homology models of Zika proteins (and other related flavivirus targets). This will enable the identification of new candidates that can then be tested in vitro, to advance the discovery and development of new antiviral drugs against the Zika virus. The docking data is being made openly accessible so that all members of the global research community can use it to further advance drug discovery studies against Zika and other related flaviviruses.

Efficient universal quantum channel simulation in IBM's cloud quantum computer

NASA Astrophysics Data System (ADS)

Wei, Shi-Jie; Xin, Tao; Long, Gui-Lu

2018-07-01

The study of quantum channels is an important field and promises a wide range of applications, because any physical process can be represented as a quantum channel that transforms an initial state into a final state. Inspired by the method of performing non-unitary operators by the linear combination of unitary operations, we proposed a quantum algorithm for the simulation of the universal single-qubit channel, described by a convex combination of "quasi-extreme" channels corresponding to four Kraus operators, and is scalable to arbitrary higher dimension. We demonstrated the whole algorithm experimentally using the universal IBM cloud-based quantum computer and studied the properties of different qubit quantum channels. We illustrated the quantum capacity of the general qubit quantum channels, which quantifies the amount of quantum information that can be protected. The behavior of quantum capacity in different channels revealed which types of noise processes can support information transmission, and which types are too destructive to protect information. There was a general agreement between the theoretical predictions and the experiments, which strongly supports our method. By realizing the arbitrary qubit channel, this work provides a universally- accepted way to explore various properties of quantum channels and novel prospect for quantum communication.

Communication overhead on the Intel Paragon, IBM SP2 and Meiko CS-2

NASA Technical Reports Server (NTRS)

Bokhari, Shahid H.

1995-01-01

Interprocessor communication overhead is a crucial measure of the power of parallel computing systems-its impact can severely limit the performance of parallel programs. This report presents measurements of communication overhead on three contemporary commercial multicomputer systems: the Intel Paragon, the IBM SP2 and the Meiko CS-2. In each case the time to communicate between processors is presented as a function of message length. The time for global synchronization and memory access is discussed. The performance of these machines in emulating hypercubes and executing random pairwise exchanges is also investigated. It is shown that the interprocessor communication time depends heavily on the specific communication pattern required. These observations contradict the commonly held belief that communication overhead on contemporary machines is independent of the placement of tasks on processors. The information presented in this report permits the evaluation of the efficiency of parallel algorithm implementations against standard baselines.

DISCOS- DYNAMIC INTERACTION SIMULATION OF CONTROLS AND STRUCTURES (IBM VERSION)

NASA Technical Reports Server (NTRS)

Frisch, H. P.

1994-01-01

calculated parameters for each body of the structure, system state vector and its time derivatives, euler angles and position coordinates and their time derivatives, control system variables and their time derivatives, and various system parameters at a given simulation time. For linearized system analysis, output includes the various transfer matrices, eigenvectors, and calculated eigenvalues. The DISCOS program is available by license for a period of ten (10) years to approved licensees. The licensed program product delivered includes the source code and supporting documentation. Additional documentation may be purchased separately at any time. The IBM version of DISCOS is written in FORTRAN IV for batch execution and has been implemented on an IBM 360 series computer under OS with a central memory requirement of approximately 1,100K of 8 bit bytes. The DEC VAX version of DISCOS is written in FORTRAN for batch execution and has been implemented on a DEC VAX series computer under VMS. For plotted output a SC4020 plotting system is required. DISCOS was developed on the IBM in 1978 and was adapted (with enhancements) to the DEC VAX in 1982.

Geometrical model for DBMS: an experimental DBMS using IBM solid modeling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ali, D.E.D.L.

1985-01-01

This research presents a new model for data base management systems (DBMS). The new model, Geometrical DBMS, is based on using solid modelling technology in designing and implementing DBMS. The Geometrical DBMS is implemented using the IBM solid modelling Geometric Design Processor (GDP). Built basically on computer-graphics concepts, Geometrical DBMS is indeed a unique model. Traditionally, researchers start with one of the existent DBMS models and then put a graphical front end on it. In Geometrical DBMS, the graphical aspect of the model is not an alien concept tailored to the model but is, as a matter of fact, themore » atom around which the model is designed. The main idea in Geometrical DBMS is to allow the user and the system to refer to and manipulate data items as a solid object in 3D space, and representing a record as a group of logically related solid objects. In Geometical DBMS, hierarchical structure is used to present the data relations and the user sees the data as a group of arrays; yet, for the user and the system together, the data structure is a multidimensional tree.« less

IBM1, a JmjC domain-containing histone demethylase, is involved in the regulation of RNA-directed DNA methylation through the epigenetic control of RDR2 and DCL3 expression in Arabidopsis

PubMed Central

Fan, Di; Dai, Yan; Wang, Xuncheng; Wang, Zhenjie; He, Hang; Yang, Hongchun; Cao, Ying; Deng, Xing Wang; Ma, Ligeng

2012-01-01

Small RNA-directed DNA methylation (RdDM) is an important epigenetic pathway in Arabidopsis that controls the expression of multiple genes and several developmental processes. RNA-DEPENDENT RNA POLYMERASE 2 (RDR2) and DICER-LIKE 3 (DCL3) are necessary factors in 24-nt small interfering RNA (siRNA) biogenesis, which is part of the RdDM pathway. Here, we found that Increase in BONSAI Methylation 1 (IBM1), a conserved JmjC family histone demethylase, is directly associated with RDR2 and DCL3 chromatin. The mutation of IBM1 induced the hypermethylation of H3K9 and DNA non-CG sites within RDR2 and DCL3, which repressed their expression. A genome-wide analysis suggested that the reduction in RDR2 and DCL3 expression affected siRNA biogenesis in a locus-specific manner and disrupted RdDM-directed gene repression. Together, our results suggest that IBM1 regulates gene expression through two distinct pathways: direct association to protect genes from silencing by preventing the coupling of histone and DNA methylation, and indirect silencing of gene expression through RdDM-directed repression. PMID:22772985

OpenZika: An IBM World Community Grid Project to Accelerate Zika Virus Drug Discovery

PubMed Central

Perryman, Alexander L.; Horta Andrade, Carolina

2016-01-01

The Zika virus outbreak in the Americas has caused global concern. To help accelerate this fight against Zika, we launched the OpenZika project. OpenZika is an IBM World Community Grid Project that uses distributed computing on millions of computers and Android devices to run docking experiments, in order to dock tens of millions of drug-like compounds against crystal structures and homology models of Zika proteins (and other related flavivirus targets). This will enable the identification of new candidates that can then be tested in vitro, to advance the discovery and development of new antiviral drugs against the Zika virus. The docking data is being made openly accessible so that all members of the global research community can use it to further advance drug discovery studies against Zika and other related flaviviruses. PMID:27764115

Training Teachers to Use Computers: A Case Study of the Summer Training Component of the IBM/ETS Secondary School Computer Education Program. Research Report.

ERIC Educational Resources Information Center

Stecher, Brian

A training program in computer educationtTested in 89 secondary schools focused on the use of computers as tools in all subject areas. Each school received enough computers and software from IBM to equip a full computer laboratory. The schools were organized into local networks in eight regions and received training and continuing support in these…

From Electrons Paired to Electric Power Delivered- A Personal Journey in Research and Applications of Superconductivity at IBM, EPRI, and Beyond

NASA Astrophysics Data System (ADS)

Grant, Paul

2014-03-01

This talk will reprise a personal journey by the speaker in industrial and applied physics, commencing with his employment by IBM at age 17 in the early 1950s, and continuing through his corporate sponsored undergraduate and graduate years at Clarkson and Harvard Universities, resulting in 1965 in a doctorate in applied physics from the latter. He was subsequently assigned by IBM to its research division in San Jose (now Almaden), where he initially carried out both pure and applied theoretical and experimental investigations encompassing a broad range of company-related product technologies...storage, display, printer and data acquisition hardware and software. In 1973, he undertook performing DFT and quantum Monte Carlo calculations in support of group research in the then emerging field of organic and polymer superconductors, a very esoteric pursuit at the time. Following upon several corporate staff assignments involving various product development and sales strategies, in 1982 he was appointed manager of the cooperative phenomena group in the Almaden Research Center, which beginning in early 1987, made significant contributions to both the basic science and applications of high temperature superconductivity (HTSC). In 1993, after a 40-year career, he retired from IBM to accept a Science Fellow position at the Electric Power Research Institute (EPRI) where he funded power application development of superconductivity. In 2004, he retired from his EPRI career to undertake ``due diligence'' consulting services in support of the venture capital community in Silicon Valley. As a ``hobby,'' he currently pursues and publishes DFT studies in hope of discovering the pairing mechanism of HTSC. In summary, the speaker's career in industrial and applied physics demonstrates one can combine publishing a record three PRLs in one month with crawling around underground in substations with utility lineman helping install superconducting cables, along the way publishing 10

Solar energy system performance evaluation: seasonal report for IBM System 4 at Clinton, Mississippi

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1980-07-01

The IBM System 4 Solar Energy System was designed to provide 35 percent of the space heating and 62 percent of the domestic hot water (DHW) preheating for a single-family residence located within the United States. The system is a prepackaged unit called the Remote Solar Assembly which has been integrated into the heating and DHW system in a dormitory in Clinton, Mississippi. The system consists of 259 square feet of Solaron 2001 Series flat-plate-air collectors, a rock thermal storage containing 5 1/2 ton of rock, heat exchangers, blowers, a 52 gallon preheat tank, controls, and associated plumbing, two 30more » gallon electric water heaters draw water from the preheat tank. A 20 kilowatt, duct mounted, electric heater supplies auxiliary energy. This system which has three modes of system operation was activated September, 1978. A system performance assessment is presented.« less

Friendly Neighborhood Computer Project. Extension of the IBM NJE network to DEC VAX computers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Raffenetti, R.C.; Bertoncini, P.J.; Engert, D.E.

1984-07-01

This manual is divided into six chapters. The first is an overview of the VAX NJE emulator system and describes what can be done with the VAX NJE emulator software. The second chapter describes the commands that users of the VAX systems will use. Each command description includes the format of the command, a list of valid options and parameters and their meanings, and several short examples of command use. The third chapter describes the commands and capabilities for sending general, sequential files from and to VAX VMS nodes. The fourth chapter describes how to transmit data to a VAXmore » from other computer systems on the network. The fifth chapter explains how to exchange electronic mail with IBM CMS users and with users of other VAX VMS systems connected by NJE communications. The sixth chapter describes operator procedures and the additional commands operators may use.« less

CLIPS 6.0 - C LANGUAGE INTEGRATED PRODUCTION SYSTEM, VERSION 6.0 (IBM PC VERSION)

NASA Technical Reports Server (NTRS)

Donnell, B.

1994-01-01

COOL (that is, a rule can pattern match on objects created using COOL). CLIPS 6.0 provides the capability to define functions, overloaded functions, and global variables interactively. In addition, CLIPS can be embedded within procedural code, called as a subroutine, and integrated with languages such as C, FORTRAN and Ada. CLIPS can be easily extended by a user through the use of several well-defined protocols. CLIPS provides several delivery options for programs including the ability to generate stand alone executables or to load programs from text or binary files. CLIPS 6.0 provides support for the modular development and execution of knowledge bases with the defmodule construct. CLIPS modules allow a set of constructs to be grouped together such that explicit control can be maintained over restricting the access of the constructs by other modules. This type of control is similar to global and local scoping used in languages such as C or Ada. By restricting access to deftemplate and defclass constructs, modules can function as blackboards, permitting only certain facts and instances to be seen by other modules. Modules are also used by rules to provide execution control. The CRSV (Cross-Reference, Style, and Verification) utility included with previous version of CLIPS is no longer supported. The capabilities provided by this tool are now available directly within CLIPS 6.0 to aid in the development, debugging, and verification of large rule bases. COSMIC offers four distribution versions of CLIPS 6.0: UNIX (MSC-22433), VMS (MSC-22434), MACINTOSH (MSC-22429), and IBM PC (MSC-22430). Executable files, source code, utilities, documentation, and examples are included on the program media. All distribution versions include identical source code for the command line version of CLIPS 6.0. This source code should compile on any platform with an ANSI C compiler. Each distribution version of CLIPS 6.0, except that for the Macintosh platform, includes an executable for the

The IBM HeadTracking Pointer: improvements in vision-based pointer control.

PubMed

Kjeldsen, Rick

2008-07-01

Vision-based head trackers have been around for some years and are even beginning to be commercialized, but problems remain with respect to usability. Users without the ability to use traditional pointing devices--the intended audience of such systems--have no alternative if the automatic bootstrapping process fails. There is room for improvement in face tracking, and the pointer movement dynamics do not support accurate and efficient pointing. This paper describes the IBM HeadTracking Pointer, a system which attempts to directly address some of these issues. Head gestures are used to provide the end user a greater level of autonomous control over the system. A novel face-tracking algorithm reduces drift under variable lighting conditions, allowing the use of absolute, rather than relative, pointer positioning. Most importantly, the pointer dynamics have been designed to take into account the constraints of head-based pointing, with a non-linear gain which allows stability in fine pointer movement, high speed on long transitions and adjustability to support users with different movement dynamics. User studies have identified some difficulties with training the system and some characteristics of the pointer motion that take time to get used to, but also good user feedback and very promising performance results.

Determination of performance characteristics of scientific applications on IBM Blue Gene/Q

DOE Office of Scientific and Technical Information (OSTI.GOV)

Evangelinos, C.; Walkup, R. E.; Sachdeva, V.

The IBM Blue Gene®/Q platform presents scientists and engineers with a rich set of hardware features such as 16 cores per chip sharing a Level 2 cache, a wide SIMD (single-instruction, multiple-data) unit, a five-dimensional torus network, and hardware support for collective operations. Especially important is the feature related to cores that have four “hardware threads,” which makes it possible to hide latencies and obtain a high fraction of the peak issue rate from each core. All of these hardware resources present unique performance-tuning opportunities on Blue Gene/Q. We provide an overview of several important applications and solvers and studymore » them on Blue Gene/Q using performance counters and Message Passing Interface profiles. We also discuss how Blue Gene/Q tools help us understand the interaction of the application with the hardware and software layers and provide guidance for optimization. Furthermore, on the basis of our analysis, we discuss code improvement strategies targeting Blue Gene/Q. Information about how these algorithms map to the Blue Gene® architecture is expected to have an impact on future system design as we move to the exascale era.« less

Maintenance Manual for AUDIT. A System for Analyzing SESCOMP Software. Volume 4: Appendix D. Listings of the AUDIT Software for the IBM 360.

DTIC Science & Technology

1977-08-01

The AUDIT documentation provides the maintenance programmer personnel with the information to effectively maintain and use the AUDIT software. The ...SESCOMPSPEC’s) and produces reports detailing the deviations from those standards. The AUDIT software also examines a program unit to detect and report...changes in word length on the output of computer programs. This report contains the listings of the AUDIT software for the IBM 360. (Author)

Solar energy system performance evaluation report for IBM System 4 at Clinton, Mississippi

NASA Technical Reports Server (NTRS)

1980-01-01

The IBM System 4 Solar Energy System is described and evaluated. The system was designed to provide 35 percent of the space heating and 63 percent of the domestic hot water preheating for a single family residence located within the United States. The system consists of 259 square feet of flat plate air collectors, a rock thermal storage containing 5 1/2 ton of rock, heat exchangers, blowers, a 52 gallon preheat tank, controls, and associated plumbing. In general, the performance of the system did not meet design expectations, since the overall design solar fraction was 48 percent and the measured value was 32 percent. Although the measured space heating solar fraction at 32 percent did agree favorably with the design space heating solar fraction at 35 percent, the hot water measured solar fraction at 33 percent did not agree favorably with the design hot water solar fraction of 63 percent. In particular collector array air leakage, dust covered collectors, abnormal hot water demand, and the preheat tank by pass valve problem are main reasons for the lower performance.

The Impact of IBM Cell Technology on the Programming Paradigm in the Context of Computer Systems for Climate and Weather Models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhou, Shujia; Duffy, Daniel; Clune, Thomas

The call for ever-increasing model resolutions and physical processes in climate and weather models demands a continual increase in computing power. The IBM Cell processor's order-of-magnitude peak performance increase over conventional processors makes it very attractive to fulfill this requirement. However, the Cell's characteristics, 256KB local memory per SPE and the new low-level communication mechanism, make it very challenging to port an application. As a trial, we selected the solar radiation component of the NASA GEOS-5 climate model, which: (1) is representative of column physics components (half the total computational time), (2) has an extremely high computational intensity: the ratiomore » of computational load to main memory transfers, and (3) exhibits embarrassingly parallel column computations. In this paper, we converted the baseline code (single-precision Fortran) to C and ported it to an IBM BladeCenter QS20. For performance, we manually SIMDize four independent columns and include several unrolling optimizations. Our results show that when compared with the baseline implementation running on one core of Intel's Xeon Woodcrest, Dempsey, and Itanium2, the Cell is approximately 8.8x, 11.6x, and 12.8x faster, respectively. Our preliminary analysis shows that the Cell can also accelerate the dynamics component (~;;25percent total computational time). We believe these dramatic performance improvements make the Cell processor very competitive as an accelerator.« less

Designing a handwashing station for infrastructure-restricted communities in Bangladesh using the integrated behavioural model for water, sanitation and hygiene interventions (IBM-WASH)

PubMed Central

2013-01-01

Background In Bangladesh diarrhoeal disease and respiratory infections contribute significantly to morbidity and mortality. Handwashing with soap reduces the risk of infection; however, handwashing rates in infrastructure-restricted settings remain low. Handwashing stations – a dedicated, convenient location where both soap and water are available for handwashing – are associated with improved handwashing practices. Our aim was to identify a locally feasible and acceptable handwashing station that enabled frequent handwashing for two subsequent randomized trials testing the health effects of this behaviour. Methods We conducted formative research in the form of household trials of improved practices in urban and rural Bangladesh. Seven candidate handwashing technologies were tested by nine to ten households each during two iterative phases. We conducted interviews with participants during an introductory visit and two to five follow up visits over two to six weeks, depending on the phase. We used the Integrated Behavioural Model for Water, Sanitation and Hygiene (IBM-WASH) to guide selection of candidate handwashing stations and data analysis. Factors presented in the IBM-WASH informed thematic coding of interview transcripts and contextualized feasibility and acceptability of specific handwashing station designs. Results Factors that influenced selection of candidate designs were market availability of low cost, durable materials that were easy to replace or replenish in an infrastructure-restricted and shared environment. Water storage capacity, ease of use and maintenance, and quality of materials determined the acceptability and feasibility of specific handwashing station designs. After examining technology, psychosocial and contextual factors, we selected a handwashing system with two different water storage capacities, each with a tap, stand, basin, soapy water bottle and detergent powder for pilot testing in preparation for the subsequent randomized

Solar energy system performance evaluation: Seasonal report for IBM system 1A, Huntsville, Alabama

NASA Technical Reports Server (NTRS)

1980-01-01

The operational and thermal performance of the solar energy system, Sims Prototype System 1A, is described. The system was designed by IBM to provide 50 to 60 percent of the space heating and domestic hot water preheating load to a 2,000 square foot floor space single family residence in the Huntsville area. The load design temperature inside the building was to be maintained at 70 degrees fahrenheit with auxiliary energy for heating supplied by an electric heat pump assisted by an electric resistance strip heater. In general the disappointing operation of this system is attributed to the manner in which it was used. The system was designed for residential application and used to satisfy the demands of an office environment. The differences were: (1) inside temperature was not maintained at 70 F as expected; and (2) hot water usage was much lower than expected. The conclusion is that the solar energy system must be designed for the type of application in which it is used. Misapplication usually will have an adverse affect on system performance.

Hf-Nd Isotopes in West Philippine Basin Basalts: Results from International Ocean Discovery Program (IODP) Site U1438 and Implications for the Early History of the Izu-Bonin-Mariana (IBM) Subduction System

NASA Astrophysics Data System (ADS)

Yogodzinski, G. M.; Hocking, B.; Bizimis, M.; Hickey-Vargas, R.; Ishizuka, O.; Bogus, K.; Arculus, R. J.

2015-12-01

Drilling at IODP Site U1438, located immediately west of Kyushu-Palau Ridge (KPR), the site of IBM subduction initiation, penetrated 1460 m of volcaniclastic sedimentary rock and 150 m of underlying basement. Biostratigraphic controls indicate a probable age for the oldest sedimentary rocks at around 55 Ma (51-64 Ma - Arculus et al., Nat Geosci in-press). This is close to the 48-52 Ma time period of IBM subduction initiation, based on studies in the forearc. There, the first products of volcanism are tholeiitic basalts termed FAB (forearc basalt), which are more depleted than average MORB and show subtle indicators of subduction geochemical enrichment (Reagan et al., 2010 - Geochem Geophy Geosy). Shipboard data indicate that Site U1438 basement basalts share many characteristics with FABs, including primitive major elements (high MgO/FeO*) and strongly depleted incompatible element patterns (Ti, Zr, Ti/V and Zr/Y below those of average MORB). Initial results thus indicate that FAB geochemistry may have been produced not only in the forearc, but also in backarc locations (west of the KPR) at the time of subduction initiation. Hf-Nd isotopes for Site 1438 basement basalts show a significant range of compositions from ɛNd of 7.0 to 9.5 and ɛHf of 14.5 to 19.8 (present-day values). The data define a well-correlated and steep array in Hf-Nd isotope space. Relatively radiogenic Hf compared to Nd indicates an Indian Ocean-type MORB source, but the dominant signature, with ɛHf >16.5, is more radiogenic than most Indian MORB. The pattern through time is from more-to-less radiogenic and more variable Hf-Nd isotopes within the basement section. This pattern culminates in basaltic andesite sills, which intrude the lower parts of the sedimentary section. The sills have the least radiogenic compositions measured so far (ɛNd ~6.6, ɛHf ~13.8), and are similar to those of boninites of the IBM forearc and modern IBM arc and reararc rocks. The pattern within the basement

EMERALD-NORMAL; PWR activity release and dose. [IBM360,370; FORTRAN IV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gillespie, S.G.; Brunot, W.K.

EMERALD-NORMAL is designed for the calculation of radiation releases and exposures resulting from normal operation of a large pressurized water reactor. The approach used is similar to an analog simulation of a real system. Each component or volume in the plant which contains a radioactive material is represented by a subroutine which keeps track of the production, transfer, decay, and absorption of radioactivity in that volume. During the course of the analysis, activity is transferred from subroutine to subroutine in the program as it would be transferred from place to place in the plant. Some of this activity is thenmore » released to the atmosphere and to the discharge canal. The rates of transfer, leakage, production, cleanup, decay, and release are read as input to the program. Subroutines are also included which calculate the off-site radiation exposures at various distances for individual isotopes and sums of isotopes. The program contains a library of physical data for the forty isotopes of most interest in licensing calculations, and other isotopes can be added or substituted. Because of the flexible nature of the simulation approach, the EMERALD-NORMAL program can be used for most calculations involving the production and release of radioactive material. These include design, operation, and licensing studies.IBM360,370; FORTRAN IV; OS/360,370; 576K bytes of memory.« less

FASTRAN II - FATIGUE CRACK GROWTH STRUCTURAL ANALYSIS (IBM PC VERSION)

NASA Technical Reports Server (NTRS)

Newman, J. C.

1994-01-01

loads may be either tensile or compressive. Several standardized aircraft flight-load histories, such as TWIST, Mini-TWIST, FALSTAFF, Inverted FALSTAFF, Felix and Gaussian, are included as options. FASTRAN II also includes two other methods that will help the user input spectrum load histories. The two methods are: (1) a list of stress points, and (2) a flight-by-flight history of stress points. Examples are provided in the user manual. Developed as a research program, FASTRAN II has successfully predicted crack growth in many metallic materials under various aircraft spectrum loading. A computer program DKEFF which is a part of the FASTRAN II package was also developed to analyze crack growth rate data from laboratory specimens to obtain the effective stress-intensity factor against crack growth rate relations used in FASTRAN II. FASTRAN II is written in standard FORTRAN 77. It has been successfully compiled and implemented on Sun4 series computers running SunOS and on IBM PC compatibles running MS-DOS using the Lahey F77L FORTRAN compiler. Sample input and output data are included with the FASTRAN II package. The UNIX version requires 660K of RAM for execution. The standard distribution medium for the UNIX version (LAR-14865) is a .25 inch streaming magnetic tape cartridge in UNIX tar format. It is also available on a 3.5 inch diskette in UNIX tar format. The standard distribution medium for the MS-DOS version (LAR-14944) is a 5.25 inch 360K MS-DOS format diskette. The contents of the diskette are compressed using the PKWARE archiving tools. The utility to unarchive the files, PKUNZIP.EXE, is included. The program was developed in 1984 and revised in 1992. Sun4 and SunOS are trademarks of Sun Microsystems, Inc. IBM PC is a trademark of International Business Machines Corp. MS-DOS is a trademark of Microsoft, Inc. F77L is a trademark of the Lahey Computer Systems, Inc. UNIX is a registered trademark of AT&T Bell Laboratories. PKWARE and PKUNZIP are trademarks of PKWare

Understanding checkpointing overheads on massive-scale systems : analysis of the IBM Blue Gene/P system.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gupta, R.; Naik, H.; Beckman, P.

Providing fault tolerance in high-end petascale systems, consisting of millions of hardware components and complex software stacks, is becoming an increasingly challenging task. Checkpointing continues to be the most prevalent technique for providing fault tolerance in such high-end systems. Considerable research has focussed on optimizing checkpointing; however, in practice, checkpointing still involves a high-cost overhead for users. In this paper, we study the checkpointing overhead seen by various applications running on leadership-class machines like the IBM Blue Gene/P at Argonne National Laboratory. In addition to studying popular applications, we design a methodology to help users understand and intelligently choose anmore » optimal checkpointing frequency to reduce the overall checkpointing overhead incurred. In particular, we study the Grid-Based Projector-Augmented Wave application, the Carr-Parrinello Molecular Dynamics application, the Nek5000 computational fluid dynamics application and the Parallel Ocean Program application-and analyze their memory usage and possible checkpointing trends on 65,536 processors of the Blue Gene/P system.« less

WRF Test on IBM BG/L:Toward High Performance Application to Regional Climate Research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chin, H S

The effects of climate change will mostly be felt on local to regional scales (Solomon et al., 2007). To develop better forecast skill in regional climate change, an integrated multi-scale modeling capability (i.e., a pair of global and regional climate models) becomes crucially important in understanding and preparing for the impacts of climate change on the temporal and spatial scales that are critical to California's and nation's future environmental quality and economical prosperity. Accurate knowledge of detailed local impact on the water management system from climate change requires a resolution of 1km or so. To this end, a high performancemore » computing platform at the petascale appears to be an essential tool in providing such local scale information to formulate high quality adaptation strategies for local and regional climate change. As a key component of this modeling system at LLNL, the Weather Research and Forecast (WRF) model is implemented and tested on the IBM BG/L machine. The objective of this study is to examine the scaling feature of WRF on BG/L for the optimal performance, and to assess the numerical accuracy of WRF solution on BG/L.« less

Intelligent Bioreactor Management Information System (IBM-IS) for Mitigation of Greenhouse Gas Emissions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Paul Imhoff; Ramin Yazdani; Don Augenstein

Methane is an important contributor to global warming with a total climate forcing estimated to be close to 20% that of carbon dioxide (CO2) over the past two decades. The largest anthropogenic source of methane in the US is 'conventional' landfills, which account for over 30% of anthropogenic emissions. While controlling greenhouse gas emissions must necessarily focus on large CO2 sources, attention to reducing CH4 emissions from landfills can result in significant reductions in greenhouse gas emissions at low cost. For example, the use of 'controlled' or bioreactor landfilling has been estimated to reduce annual US greenhouse emissions by aboutmore » 15-30 million tons of CO2 carbon (equivalent) at costs between $3-13/ton carbon. In this project we developed or advanced new management approaches, landfill designs, and landfill operating procedures for bioreactor landfills. These advances are needed to address lingering concerns about bioreactor landfills (e.g., efficient collection of increased CH4 generation) in the waste management industry, concerns that hamper bioreactor implementation and the consequent reductions in CH4 emissions. Collectively, the advances described in this report should result in better control of bioreactor landfills and reductions in CH4 emissions. Several advances are important components of an Intelligent Bioreactor Management Information System (IBM-IS).« less

Shape coexistence close to N = 50 in the neutron-rich isotope 80Ge investigated by IBM-2

NASA Astrophysics Data System (ADS)

Zhang, Da-Li; Mu, Cheng-Fu

2018-02-01

The properties of the low-lying states, especially the relevant shape coexistence in 80Ge, close to one of most neutron-rich doubly magic nuclei at N = 50 and Z = 28, have been investigated within the framework of the proton-neutron interacting model (IBM-2). Based on the fact that the relative energy of the d neutron boson is different from that of the proton boson, the calculated energy levels of low-lying states and E2 transition strengths can reproduce the experimental data very well. Particularly, the first excited state {0}2+, which is intimately related to the shape coexistence phenomenon, is reproduced quite nicely. The {ρ }2(E0,{0}2+\\to {0}1+) transition strength is also predicted. The experimental data and theoretical results indicate that both collective spherical and γ-soft vibration structures coexist in 80Ge. Supported by National Natural Science Foundation of China (11475062, 11647306, 11147148)

Tactical swimming activity and heart rate aspects of youth water polo game.

PubMed

Lupo, Corrado; Capranica, Laura; Cugliari, Giovanni; Gomez, Miguel A; Tessitore, Antonio

2016-09-01

Although physical demands could differently occur during particular phases of the youth water polo game, at present, literature lacks of time-motion and heart rate data referred to specific tactical situation. Therefore, the present study aimed to analyze a youth water polo game, specifying heart rate, and swimming activity aspects in relation to game situations. Twenty-six youth male players (15.6±0.5 years old) voluntary played a friendly game, which was tactically analyzed (offensive and defensive Even and Counterattack situation, and Power-play, Inferiority and Game Breaks) using notational analysis procedures. Successively, the heart rate (aerobic, anaerobic) and time motion (horizontal, vertical, and duel swimming patterns, with and without ball possession, backstroke) analyses were applied only to six (3 for team) players because they performed at list half of the total game duration. The tactical scenarios were mainly characterized by offensive (33%) and defensive (33%) even possessions, and game breaks (23%). No effect emerged between situations in terms of heart rate distribution, because it principally resulted as aerobic (range: 58-97%). The swimming activity analysis mainly showed differences (P≤0.05) between offensive counterattack and power-play in terms of distance (1 min of game, single pattern), time duration (1 min of game), and speed (single pattern) related to the horizontal activity. Repeated high intensity activities were performed 3.0±2.8 (range: 1-7) during the game. The findings of the present study provide important information for the planning of youth water polo training, with specific reference to playing situations.

Scalability study of parallel spatial direct numerical simulation code on IBM SP1 parallel supercomputer

NASA Technical Reports Server (NTRS)

Hanebutte, Ulf R.; Joslin, Ronald D.; Zubair, Mohammad

1994-01-01

The implementation and the performance of a parallel spatial direct numerical simulation (PSDNS) code are reported for the IBM SP1 supercomputer. The spatially evolving disturbances that are associated with laminar-to-turbulent in three-dimensional boundary-layer flows are computed with the PS-DNS code. By remapping the distributed data structure during the course of the calculation, optimized serial library routines can be utilized that substantially increase the computational performance. Although the remapping incurs a high communication penalty, the parallel efficiency of the code remains above 40% for all performed calculations. By using appropriate compile options and optimized library routines, the serial code achieves 52-56 Mflops on a single node of the SP1 (45% of theoretical peak performance). The actual performance of the PSDNS code on the SP1 is evaluated with a 'real world' simulation that consists of 1.7 million grid points. One time step of this simulation is calculated on eight nodes of the SP1 in the same time as required by a Cray Y/MP for the same simulation. The scalability information provides estimated computational costs that match the actual costs relative to changes in the number of grid points.

A nested mechanistic sub-study into the effect of tranexamic acid versus placebo on intracranial haemorrhage and cerebral ischaemia in isolated traumatic brain injury: study protocol for a randomised controlled trial (CRASH-3 Trial Intracranial Bleeding Mechanistic Sub-Study [CRASH-3 IBMS]).

PubMed

Mahmood, Abda; Roberts, Ian; Shakur, Haleema

2017-07-17

Tranexamic acid prevents blood clots from breaking down and reduces bleeding. However, it is uncertain whether tranexamic acid is effective in traumatic brain injury. The CRASH-3 trial is a randomised controlled trial that will examine the effect of tranexamic acid (versus placebo) on death and disability in 13,000 patients with traumatic brain injury. The CRASH-3 trial hypothesizes that tranexamic acid will reduce intracranial haemorrhage, which will reduce the risk of death. Although it is possible that tranexamic acid will reduce intracranial bleeding, there is also a potential for harm. In particular, tranexamic acid may increase the risk of cerebral thrombosis and ischaemia. The protocol detailed here is for a mechanistic sub-study nested within the CRASH-3 trial. This mechanistic sub-study aims to examine the effect of tranexamic acid (versus placebo) on intracranial bleeding and cerebral ischaemia. The CRASH-3 Intracranial Bleeding Mechanistic Sub-Study (CRASH-3 IBMS) is nested within a prospective, double-blind, multi-centre, parallel-arm randomised trial called the CRASH-3 trial. The CRASH-3 IBMS will be conducted in a cohort of approximately 1000 isolated traumatic brain injury patients enrolled in the CRASH-3 trial. In the CRASH-3 IBMS, brain scans acquired before and after randomisation are examined, using validated methods, for evidence of intracranial bleeding and cerebral ischaemia. The primary outcome is the total volume of intracranial bleeding measured on computed tomography after randomisation, adjusting for baseline bleeding volume. Secondary outcomes include progression of intracranial haemorrhage (from pre- to post-randomisation scans), new intracranial haemorrhage (seen on post- but not pre-randomisation scans), intracranial haemorrhage following neurosurgery, and new focal ischaemic lesions (seen on post-but not pre-randomisation scans). A linear regression model will examine whether receipt of the trial treatment can predict haemorrhage

Integrating Biodiversity into Biosphere-Atmosphere Interactions Using Individual-Based Models (IBM)

NASA Astrophysics Data System (ADS)

Wang, B.; Shugart, H. H., Jr.; Lerdau, M.

2017-12-01

A key component regulating complex, nonlinear, and dynamic biosphere-atmosphere interactions is the inherent diversity of biological systems. The model frameworks currently widely used, i.e., Plant Functional Type models) do not even begin to capture the metabolic and taxonomic diversity found in many terrestrial systems. We propose that a transition from PFT-based to individual-based modeling approaches (hereafter referred to as IBM) is essential for integrating biodiversity into research on biosphere-atmosphere interactions. The proposal emerges from our studying the interactions of forests with atmospheric processes in the context of climate change using an individual-based forest volatile organic compounds model, UVAFME-VOC. This individual-based model can explicitly simulate VOC emissions based on an explicit modelling of forest dynamics by computing the growth, death, and regeneration of each individual tree of different species and their competition for light, moisture, and nutrient, from which system-level VOC emissions are simulated by explicitly computing and summing up each individual's emissions. We found that elevated O3 significantly altered the forest dynamics by favoring species that are O3-resistant, which, meanwhile, are producers of isoprene. Such compositional changes, on the one hand, resulted in unsuppressed forest productivity and carbon stock because of the compensation by O3-resistant species. On the other hand, with more isoprene produced arising from increased producers, a possible positive feedback loop between tropospheric O3 and forest thereby emerged. We also found that climate warming will not always stimulate isoprene emissions because warming simultaneously reduces isoprene emissions by causing a decline in the abundance of isoprene-emitting species. These results suggest that species diversity is of great significance and that individual-based modelling strategies should be applied in studying biosphere-atmosphere interactions.

Programming for 1.6 Millon cores: Early experiences with IBM's BG/Q SMP architecture

NASA Astrophysics Data System (ADS)

Glosli, James

2013-03-01

With the stall in clock cycle improvements a decade ago, the drive for computational performance has continues along a path of increasing core counts on a processor. The multi-core evolution has been expressed in both a symmetric multi processor (SMP) architecture and cpu/GPU architecture. Debates rage in the high performance computing (HPC) community which architecture best serves HPC. In this talk I will not attempt to resolve that debate but perhaps fuel it. I will discuss the experience of exploiting Sequoia, a 98304 node IBM Blue Gene/Q SMP at Lawrence Livermore National Laboratory. The advantages and challenges of leveraging the computational power BG/Q will be detailed through the discussion of two applications. The first application is a Molecular Dynamics code called ddcMD. This is a code developed over the last decade at LLNL and ported to BG/Q. The second application is a cardiac modeling code called Cardioid. This is a code that was recently designed and developed at LLNL to exploit the fine scale parallelism of BG/Q's SMP architecture. Through the lenses of these efforts I'll illustrate the need to rethink how we express and implement our computational approaches. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

IODP Expedition 351 Lithostratigraphy: Volcaniclastic Record of Izu-Bonin-Mariana (IBM) Arc Initiation

NASA Astrophysics Data System (ADS)

Barth, A. P.; Brandl, P. A.; Li, H.; Hickey-Vargas, R.; Jiang, F.; Kanayama, K.; Kusano, Y.; Marsaglia, K. M.; McCarthy, A.; Meffre, S.; Savov, I. P.; Tepley, F. J., III; Yogodzinski, G. M.

2014-12-01

The destruction of lithospheric plates by subduction is a fundamentally important process leading to arc magmatism and the creation of continental crust, yet subduction initiation and early magmatic arc evolution remain poorly understood. For many arc systems, onset of arc volcanism and early evolution are obscured by metamorphism or the record is deeply buried; however, initial products of arc systems may be preserved in forearc and backarc sedimentary records. IODP Expedition 351 recovered this history from the dispersed ash and pyroclast record in the proximal rear-arc of the northern IBM system west of the Kyushu-Palau Ridge. Drilling at Site U1438 in the Amami Sankaku Basin recovered a thick volcaniclastic record of subduction initiation and the early evolution of the Izu-Bonin Arc. A 160-m thick section of Neogene sediment overlies 1.3 kilometers of Paleogene volcaniclastic rocks with andesitic average composition; this volcaniclastic section was deposited on mafic volcanic basement rocks. The thin upper sediment layer is primarily terrigenous, biogenic and volcaniclastic mud and ooze with interspersed ash layers. The underlying Eocene to Oligocene volcaniclastic rocks are 33% tuffaceous mudstone, 61% tuffaceous sandstone, and 6% conglomerate with volcanic and rare sedimentary clasts commonly up to pebble and rarely to cobble size. The clastic section is characterized by repetitive conglomerate and sandstone-dominated intervals with intervening mudstone-dominated intervals, reflecting waxing and waning of coarse arc-derived sediment inputs through time. Volcanic lithic clasts in sandstones and conglomerates range from basalt to rhyolite in composition and include well-preserved pumice, reflecting a lithologically diverse and compositionally variable arc volcanic source.

The genetic basis of natural variation for iron homeostasis in the maize IBM population

PubMed Central

2014-01-01

Background Iron (Fe) deficiency symptoms in maize (Zea mays subsp. mays) express as leaf chlorosis, growth retardation, as well as yield reduction and are typically observed when plants grow in calcareous soils at alkaline pH. To improve our understanding of genotypical variability in the tolerance to Fe deficiency-induced chlorosis, the objectives of this study were to (i) determine the natural genetic variation of traits related to Fe homeostasis in the maize intermated B73 × Mo17 (IBM) population, (ii) to identify quantitative trait loci (QTLs) for these traits, and (iii) to analyze expression levels of genes known to be involved in Fe homeostasis as well as of candidate genes obtained from the QTL analysis. Results In hydroponically-grown maize, a total of 47 and 39 QTLs were detected for the traits recorded under limited and adequate supply of Fe, respectively. Conclusions From the QTL results, we were able to identify new putative candidate genes involved in Fe homeostasis under a deficient or adequate Fe nutritional status, like Ferredoxin class gene, putative ferredoxin PETF, metal tolerance protein MTP4, and MTP8. Furthermore, our expression analysis of candidate genes suggested the importance of trans-acting regulation for 2’-deoxymugineic acid synthase 1 (DMAS1), nicotianamine synthase (NAS3, NAS1), formate dehydrogenase 1 (FDH1), methylthioribose-1-phosphate isomerase (IDI2), aspartate/tyrosine/aromatic aminotransferase (IDI4), and methylthioribose kinase (MTK). PMID:24400634

A study of application of remote sensing to river forecasting. Volume 2: Detailed technical report, NASA-IBM streamflow forecast model user's guide

NASA Technical Reports Server (NTRS)

1975-01-01

The Model is described along with data preparation, determining model parameters, initializing and optimizing parameters (calibration) selecting control options and interpreting results. Some background information is included, and appendices contain a dictionary of variables, a source program listing, and flow charts. The model was operated on an IBM System/360 Model 44, using a model 2250 keyboard/graphics terminal for interactive operation. The model can be set up and operated in a batch processing mode on any System/360 or 370 that has the memory capacity. The model requires 210K bytes of core storage, and the optimization program, OPSET (which was used previous to but not in this study), requires 240K bytes. The data band for one small watershed requires approximately 32 tracks of disk storage.

[Efficiency of includes of bioactive substances in diet of patient with hepatic encephalopathy].

PubMed

Kaziulin, A N; Petukhov, A B; Kucheriavyĭ, Iu A

2006-01-01

We includes 66 patients with liver cirrhosis of Child-Pugh B class with hepatic encephalopathy of 0 to 2nd stages in randomized interventional study. 36 patients received standard treatment and 30 patients received standard treatment + bioactive substances in formula CognoBlend in capsules (2 capsules twice a day) in course of 5 weeks. Formula includes extracts of plants: Bacopa monneria, Gingko biloba, Cat's Claw, Gotu Kola, Rosemary. In group combined treatment was significant improvement of clinical signs, psychometric tests, electroencephalography and serum biochemistry than in group with standard therapy, on term of 2 to 5 weeks.

Performance of a Block Structured, Hierarchical Adaptive MeshRefinement Code on the 64k Node IBM BlueGene/L Computer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Greenough, Jeffrey A.; de Supinski, Bronis R.; Yates, Robert K.

2005-04-25

We describe the performance of the block-structured Adaptive Mesh Refinement (AMR) code Raptor on the 32k node IBM BlueGene/L computer. This machine represents a significant step forward towards petascale computing. As such, it presents Raptor with many challenges for utilizing the hardware efficiently. In terms of performance, Raptor shows excellent weak and strong scaling when running in single level mode (no adaptivity). Hardware performance monitors show Raptor achieves an aggregate performance of 3:0 Tflops in the main integration kernel on the 32k system. Results from preliminary AMR runs on a prototype astrophysical problem demonstrate the efficiency of the current softwaremore » when running at large scale. The BG/L system is enabling a physics problem to be considered that represents a factor of 64 increase in overall size compared to the largest ones of this type computed to date. Finally, we provide a description of the development work currently underway to address our inefficiencies.« less

Geochemistry of Volcanic Rocks from International Ocean Discovery Program (IODP) Site 1438, Amami Sankaku Basin: Implications for Izu-Bonin-Mariana (IBM) Arc Initiation

NASA Astrophysics Data System (ADS)

Hickey-Vargas, R.; Ishizuka, O.; Yogodzinski, G. M.; Bizimis, M.; Savov, I. P.; McCarthy, A. J.; Arculus, R. J.; Bogus, K.

2015-12-01

IODP Expedition 351 drilled 150 m of volcanic basement overlain by 1461 m of sedimentary material at Site 1438 in the Amami Sankaku basin, just west of the Kyushu Palau Ridge, the locus of IBM arc initiation. Age interpretations based on biostratigraphy (Arculus et al., Nat. Geosci., in-press) determined that the age of the basement section is between 64 and 51 Ma, encompassing the age of the earliest volcanic products of the IBM arc. The Site 1438 volcanic basement consists of multiple flows of aphyric microcrystalline to finely crystalline basalts containing plagioclase and clinopyroxene with rare olivine pseudomorphs. New XRF major and ICPMS trace element data confirm findings of shipboard analysis that the basalts are moderately differentiated (6-14 % MgO; Mg# = 51-83; 73-490 ppm Cr and 58-350 ppm Ni) with downcore variations related to flow units. Ti/V and Ti/Sc ratios are 16-27 and 75-152, respectively, with lowest values at the base of the core. One prominent characteristic of the basalts is their depletion of immobile highly incompatible elements compared with MORB. Basalts have MORB-normalized La/Nd of 0.5 to 0.9, and most have Th/La < 0.05. Although all basalts are LREE-depleted, La/Nd ratios increase slightly upcore, and Th enrichment compared with LREE occurs in the uppermost 5 meters. Cs, Rb, K, Ba and U are concomitantly enriched relative to LREE in several intervals as a probable result of seawater alteration, but ratios less than those of MORB are found in other areas. In contrast to basement, andesites from three sills in the lowermost sedimentary unit have arc-like trace element patterns with La/Nb > 3 and primitive mantle normalized La/Yb > 1. Our results suggest that mantle melting at the onset of subduction involved exceptionally depleted sources. Enrichment over time may be related to increasing subduction inputs and/or other processes, such as entrainment of fertile asthenosphere during extension of the overriding plate.

Neurotechnology and society (2010-2060).

PubMed

Lynch, Zack

2004-05-01

To illuminate the societal implications of NBIC (nano-bio-info-cogno) technologies it is critical to place them within a broad historical context. By viewing recent human history as a series of techno-economic waves with accompanying socio-political responses, a framework emerges that can be used to understand how business, politics, and human culture will be affected by NBIC technologies. One important development that the NBIC convergence is making possible is neurotechnology, the set of tools that can influence the human central nervous system, especially the brain. The diffusion of neurotechnology will give rise to a new type of human society-a post-industrial, post-informational neurosociety.

Biomedical informatics and the convergence of Nano-Bio-Info-Cogno (NBIC) technologies.

PubMed

Martin-Sanchez, F; Maojo, V

2009-01-01

To analyze the role that biomedical informatics could play in the application of the NBIC Converging Technologies in the medical field and raise awareness of these new areas throughout the Biomedical Informatics community. Review of the literature and analysis of the reference documents in this domain from the biomedical informatics perspective. Detailing existing developments showing that partial convergence of technologies have already yielded relevant results in biomedicine (such as bioinformatics or biochips). Input from current projects in which the authors are involved is also used. Information processing is a key issue in enabling the convergence of NBIC technologies. Researchers in biomedical informatics are in a privileged position to participate and actively develop this new scientific direction. The experience of biomedical informaticians in five decades of research in the medical area and their involvement in the completion of the Human and other genome projects will help them participate in a similar role for the development of applications of converging technologies -particularly in nanomedicine. The proposed convergence will bring bridges between traditional disciplines. Particular attention should be placed on the ethical, legal, and social issues raised by the NBIC convergence. These technologies provide new directions for research and education in Biomedical Informatics placing a greater emphasis in multidisciplinary approaches.

NAS Experiences of Porting CM Fortran Codes to HPF on IBM SP2 and SGI Power Challenge

NASA Technical Reports Server (NTRS)

Saini, Subhash

1995-01-01

Current Connection Machine (CM) Fortran codes developed for the CM-2 and the CM-5 represent an important class of parallel applications. Several users have employed CM Fortran codes in production mode on the CM-2 and the CM-5 for the last five to six years, constituting a heavy investment in terms of cost and time. With Thinking Machines Corporation's decision to withdraw from the hardware business and with the decommissioning of many CM-2 and CM-5 machines, the best way to protect the substantial investment in CM Fortran codes is to port the codes to High Performance Fortran (HPF) on highly parallel systems. HPF is very similar to CM Fortran and thus represents a natural transition. Conversion issues involved in porting CM Fortran codes on the CM-5 to HPF are presented. In particular, the differences between data distribution directives and the CM Fortran Utility Routines Library, as well as the equivalent functionality in the HPF Library are discussed. Several CM Fortran codes (Cannon algorithm for matrix-matrix multiplication, Linear solver Ax=b, 1-D convolution for 2-D datasets, Laplace's Equation solver, and Direct Simulation Monte Carlo (DSMC) codes have been ported to Subset HPF on the IBM SP2 and the SGI Power Challenge. Speedup ratios versus number of processors for the Linear solver and DSMC code are presented.

A method for transferring NASTRAN data between dissimilar computers. [application to CDC 6000 series, IBM 360-370 series, and Univac 1100 series computers

NASA Technical Reports Server (NTRS)

Rogers, J. L., Jr.

1973-01-01

The NASTRAN computer program is capable of executing on three different types of computers: (1) the CDC 6000 series, (2) the IBM 360-370 series, and (3) the Univac 1100 series. A typical activity requiring transfer of data between dissimilar computers is the analysis of a large structure such as the space shuttle by substructuring. Models of portions of the vehicle which have been analyzed by subcontractors using their computers must be integrated into a model of the complete structure by the prime contractor on his computer. Presently the transfer of NASTRAN matrices or tables between two different types of computers is accomplished by punched cards or a magnetic tape containing card images. These methods of data transfer do not satisfy the requirements for intercomputer data transfer associated with a substructuring activity. To provide a more satisfactory transfer of data, two new programs, RDUSER and WRTUSER, were created.

Evolving management of low grade glioma: No consensus amongst treating clinicians.

PubMed

Field, K M; Rosenthal, M A; Khasraw, M; Sawkins, K; Nowak, A K

2016-01-01

Following the widely publicized presentation of the Radiation Therapy Oncology Group (RTOG) 9802 data, we sought to understand how these data had been translated to the management of low grade gliomas (LGG) by Australian neuro-oncology clinicians. The de novo management of LGG is transitioning to include postoperative radiotherapy and chemotherapy after the RTOG 9802 study results demonstrated a survival benefit in this setting. In 2014, neurosurgeons, radiation oncologists and neuro-oncologists who were members of the Australian Cooperative Trials Group for Neuro-oncology (COGNO), as well as additional attendants of the COGNO annual scientific meeting, were surveyed. The survey presented six LGG clinical scenarios and asked respondents to select their preferred management strategy. Some additional questions included the respondents' approach to 1p/19q testing and chemotherapy preferences. The response rate was 30.2% (61/202), with the majority (77%) working in tertiary referral neuro-oncology centers. There was no consensus regarding the management approach for each scenario, with postsurgery observation alone remaining a popular strategy. Only 25% of respondents reported that their institution routinely tests for 1p/19q status in LGG, although 69% were of the opinion that all LGG patients should be tested. The majority (81%) preferred to use temozolomide rather than the procarbazine, lomustine, and vincristine combination as the first line chemotherapy for LGG, but only 44% would actually use it in this setting. Up front chemotherapy, prior to radiotherapy, would be considered by 52% of respondents for certain LGG patients. This survey assessed the management strategies for LGG since the updated RTOG 9802 data were presented. It demonstrates no consensus in the postoperative treatment approaches for LGG. Copyright © 2015 Elsevier Ltd. All rights reserved.

We have AN Increasing Need to Model Ourselves

NASA Astrophysics Data System (ADS)

Farmer, J. Doyne

Pierre Teilhard de Chardin referred to the fusion of biological life, human culture, and technology as the noosphere. Technological improvement is causing the noosphere to evolve rapidly, driving the enormous increase in human population over the last 10,000 years and the transformation (and devastation) of the biosphere. The rapid proliferation of the internet is changing human culture, including everything from the way we find mates to the way democracy functions, or fails to function. The emergence of the BINC (Bio, Info, Nano, Cogno) technologies promises to further accelerate this change. We are acquiring an ever-increasing ability to engineer devices at a molecular level, to control the genome, and to create new forms of life and intelligence...

Quantitative Trait Locus Analysis for Deep-Sowing Germination Ability in the Maize IBM Syn10 DH Population

PubMed Central

Liu, Hongjun; Zhang, Lin; Wang, Jiechen; Li, Changsheng; Zeng, Xing; Xie, Shupeng; Zhang, Yongzhong; Liu, Sisi; Hu, Songlin; Wang, Jianhua; Lee, Michael; Lübberstedt, Thomas; Zhao, Guangwu

2017-01-01

Deep-sowing is an effective measure to ensure seeds absorbing water from deep soil layer and emerging normally in arid and semiarid regions. However, existing varieties demonstrate poor germination ability in deep soil layer and some key quantitative trait loci (QTL) or genes related to deep-sowing germination ability remain to be identified and analyzed. In this study, a high-resolution genetic map based on 280 lines of the intermated B73 × Mo17 (IBM) Syn10 doubled haploid (DH) population which comprised 6618 bin markers was used for the QTL analysis of deep-sowing germination related traits. The results showed significant differences in germination related traits under deep-sowing condition (12.5 cm) and standard-germination condition (2 cm) between two parental lines. In total, 8, 11, 13, 15, and 18 QTL for germination rate, seedling length, mesocotyl length, plumule length, and coleoptile length were detected for the two sowing conditions, respectively. These QTL explained 2.51–7.8% of the phenotypic variance with LOD scores ranging from 2.52 to 7.13. Additionally, 32 overlapping QTL formed 11 QTL clusters on all chromosomes except for chromosome 8, indicating the minor effect genes have a pleiotropic role in regulating various traits. Furthermore, we identified six candidate genes related to deep-sowing germination ability, which were co-located in the cluster regions. The results provide a basis for molecular marker assisted breeding and functional study in deep-sowing germination ability of maize. PMID:28588594

Quantitative Trait Locus Analysis for Deep-Sowing Germination Ability in the Maize IBM Syn10 DH Population.

PubMed

Liu, Hongjun; Zhang, Lin; Wang, Jiechen; Li, Changsheng; Zeng, Xing; Xie, Shupeng; Zhang, Yongzhong; Liu, Sisi; Hu, Songlin; Wang, Jianhua; Lee, Michael; Lübberstedt, Thomas; Zhao, Guangwu

2017-01-01

Deep-sowing is an effective measure to ensure seeds absorbing water from deep soil layer and emerging normally in arid and semiarid regions. However, existing varieties demonstrate poor germination ability in deep soil layer and some key quantitative trait loci (QTL) or genes related to deep-sowing germination ability remain to be identified and analyzed. In this study, a high-resolution genetic map based on 280 lines of the intermated B73 × Mo17 (IBM) Syn10 doubled haploid (DH) population which comprised 6618 bin markers was used for the QTL analysis of deep-sowing germination related traits. The results showed significant differences in germination related traits under deep-sowing condition (12.5 cm) and standard-germination condition (2 cm) between two parental lines. In total, 8, 11, 13, 15, and 18 QTL for germination rate, seedling length, mesocotyl length, plumule length, and coleoptile length were detected for the two sowing conditions, respectively. These QTL explained 2.51-7.8% of the phenotypic variance with LOD scores ranging from 2.52 to 7.13. Additionally, 32 overlapping QTL formed 11 QTL clusters on all chromosomes except for chromosome 8, indicating the minor effect genes have a pleiotropic role in regulating various traits. Furthermore, we identified six candidate genes related to deep-sowing germination ability, which were co-located in the cluster regions. The results provide a basis for molecular marker assisted breeding and functional study in deep-sowing germination ability of maize.

QTL Mapping of Low-Temperature Germination Ability in the Maize IBM Syn4 RIL Population

PubMed Central

Hu, Shuaidong; Lübberstedt, Thomas; Zhao, Guangwu; Lee, Michael

2016-01-01

Low temperature is the primary factor to affect maize sowing in early spring. It is, therefore, vital for maize breeding programs to improve tolerance to low temperatures at seed germination stage. However, little is known about maize QTL involved in low-temperature germination ability. 243 lines of the intermated B73×Mo17 (IBM) Syn4 recombinant inbred line (RIL) population was used for QTL analysis of low-temperature germination ability. There were significant differences in germination-related traits under both conditions of low temperature (12°C/16h, 18°C/8h) and optimum temperature (28°C/24h) between the parental lines. Only three QTL were identified for controlling optimum-temperature germination rate. Six QTL controlling low-temperature germination rate were detected on chromosome 4, 5, 6, 7 and 9, and contribution rate of single QTL explained between 3.39%~11.29%. In addition, six QTL controlling low-temperature primary root length were detected in chromosome 4, 5, 6, and 9, and the contribution rate of single QTL explained between 3.96%~8.41%. Four pairs of QTL were located at the same chromosome position and together controlled germination rate and primary root length under low temperature condition. The nearest markers apart from the corresponding QTL (only 0.01 cM) were umc1303 (265.1 cM) on chromosome 4, umc1 (246.4 cM) on chromosome 5, umc62 (459.1 cM) on chromosome 6, bnl14.28a (477.4 cM) on chromosome 9, respectively. A total of 3155 candidate genes were extracted from nine separate intervals based on the Maize Genetics and Genomics Database (http://www.maizegdb.org). Five candidate genes were selected for analysis as candidates putatively affecting seed germination and seedling growth at low temperature. The results provided a basis for further fine mapping, molecular marker assisted breeding and functional study of cold-tolerance at the stage of seed germination in maize. PMID:27031623

Engraftment Efficiency after Intra-Bone Marrow versus Intravenous Transplantation of Bone Marrow Cells in a Canine Nonmyeloablative Dog Leukocyte Antigen-Identical Transplantation Model.

PubMed

Lange, Sandra; Steder, Anne; Killian, Doreen; Knuebel, Gudrun; Sekora, Anett; Vogel, Heike; Lindner, Iris; Dunkelmann, Simone; Prall, Friedrich; Murua Escobar, Hugo; Freund, Mathias; Junghanss, Christian

2017-02-01

An intra-bone marrow (IBM) hematopoietic stem cell transplantation (HSCT) is assumed to optimize the homing process and therefore to improve engraftment as well as hematopoietic recovery compared with conventional i.v. HSCT. This study investigated the feasibility and efficacy of IBM HSCT after nonmyeloablative conditioning in an allogeneic canine HSCT model. Two study cohorts received IBM HSCT of either density gradient (IBM-I, n = 7) or buffy coat (IBM-II, n = 6) enriched bone marrow cells. An historical i.v. HSCT cohort served as control. Before allogeneic HSCT experiments were performed, we investigated the feasibility of IBM HSCT by using technetium-99m marked autologous grafts. Scintigraphic analyses confirmed that most IBM-injected autologous cells remained at the injection sites, independent of the applied volume. In addition, cell migration to other bones occurred. The enrichment process led to different allogeneic graft volumes (IBM-I, 2 × 5 mL; IBM-II, 2 × 25 mL) and significantly lower counts of total nucleated cells in IBM-I grafts compared with IBM-II grafts (1.6 × 10 8 /kg versus 3.8 × 10 8 /kg). After allogeneic HSCT, dogs of the IBM-I group showed a delayed engraftment with lower levels of donor chimerism when compared with IBM-II or to i.v. HSCT. Dogs of the IBM-II group tended to reveal slightly faster early leukocyte engraftment kinetics than intravenously transplanted animals. However, thrombocytopenia was significantly prolonged in both IBM groups when compared with i.v. HSCT. In conclusion, IBM HSCT is feasible in a nonmyeloablative HSCT setting but failed to significantly improve engraftment kinetics and hematopoietic recovery in comparison with conventional i.v. HSCT. Copyright © 2017 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

Scalability of Parallel Spatial Direct Numerical Simulations on Intel Hypercube and IBM SP1 and SP2

NASA Technical Reports Server (NTRS)

Joslin, Ronald D.; Hanebutte, Ulf R.; Zubair, Mohammad

1995-01-01

The implementation and performance of a parallel spatial direct numerical simulation (PSDNS) approach on the Intel iPSC/860 hypercube and IBM SP1 and SP2 parallel computers is documented. Spatially evolving disturbances associated with the laminar-to-turbulent transition in boundary-layer flows are computed with the PSDNS code. The feasibility of using the PSDNS to perform transition studies on these computers is examined. The results indicate that PSDNS approach can effectively be parallelized on a distributed-memory parallel machine by remapping the distributed data structure during the course of the calculation. Scalability information is provided to estimate computational costs to match the actual costs relative to changes in the number of grid points. By increasing the number of processors, slower than linear speedups are achieved with optimized (machine-dependent library) routines. This slower than linear speedup results because the computational cost is dominated by FFT routine, which yields less than ideal speedups. By using appropriate compile options and optimized library routines on the SP1, the serial code achieves 52-56 M ops on a single node of the SP1 (45 percent of theoretical peak performance). The actual performance of the PSDNS code on the SP1 is evaluated with a "real world" simulation that consists of 1.7 million grid points. One time step of this simulation is calculated on eight nodes of the SP1 in the same time as required by a Cray Y/MP supercomputer. For the same simulation, 32-nodes of the SP1 and SP2 are required to reach the performance of a Cray C-90. A 32 node SP1 (SP2) configuration is 2.9 (4.6) times faster than a Cray Y/MP for this simulation, while the hypercube is roughly 2 times slower than the Y/MP for this application. KEY WORDS: Spatial direct numerical simulations; incompressible viscous flows; spectral methods; finite differences; parallel computing.

Imprinted-like biopolymeric micelles as efficient nanovehicles for curcumin delivery.

PubMed

Zhang, Lili; Qi, Zeyou; Huang, Qiyu; Zeng, Ke; Sun, Xiaoyi; Li, Juan; Liu, You-Nian

2014-11-01

To enhance the solubility and improve the bioavailability of hydrophobic curcumin, a new kind of imprinted-like biopolymeric micelles (IBMs) was designed. The IBMs were prepared via co-assembly of gelatin-dextran conjugates with hydrophilic tea polyphenol, then crosslinking the assembled micelles and finally removing the template tea polyphenol by dialysis. The obtained IBMs show selective binding for polyphenol analogous drugs over other drugs. Furthermore, curcumin can be effectively encapsulated into the IBMs with 5×10(4)-fold enhancement of aqueous solubility. We observed the sustained drug release behavior from the curcumin-loaded IBMs (CUR@IBMs) in typical biological buffers. In addition, we found the cell uptake of CUR@IBMs is much higher than that of free curcumin. The cell cytotoxicity results illustrated that CUR@IBMs can improve the growth inhibition of HeLa cells compared with free curcumin, while the blank IBMs have little cytotoxicity. The in vivo animal study demonstrated that the IBMs could significantly improve the oral bioavailability of curcumin. Copyright © 2014 Elsevier B.V. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sudman, D.L.

For 17 years, the sensor-based IBM 1800 computer successfully fulfilled Sun's requirements for data acquisition and process control at its petroleum refinery in Toledo, Ohio. However, faltering reliability due to deterioration, coupled with IBM's announced withdrawal of contractual hardware maintenance, prompted Sun to approach IBM regarding potential solutions to the problem of economically maintaining the IBM 1800 as a viable system in the Toledo Refinery. In concert, IBM and Sun identified several options, but an IBM proposal which held the most promise for long term success was the direct replacement of the IBM 1800 processor and software systems with anmore » IBM 4300 running IBM's licensed program product ''Advanced Control System,'' i.e., ACS. Sun chose this solution. The intent of this paper is to chronicle the highlights of the project which successfully revitalized the process computer facilities in Sun's Toledo Refinery in only 10 months, under financial constraints, and using limited human resources.« less

Comparative utility of LC3, p62 and TDP-43 immunohistochemistry in differentiation of inclusion body myositis from polymyositis and related inflammatory myopathies

PubMed Central

2013-01-01

Background Inclusion body myositis (IBM) is a slowly progressive inflammatory myopathy of the elderly that does not show significant clinical improvement in response to steroid therapy. Distinguishing IBM from polymyositis (PM) is clinically important since PM is steroid-responsive; however, the two conditions can show substantial histologic overlap. Results We performed quantitative immunohistochemistry for (1) autophagic markers LC3 and p62 and (2) protein aggregation marker TDP-43 in 53 subjects with pathologically diagnosed PM, IBM, and two intermediate T cell-mediated inflammatory myopathies (polymyositis with COX-negative fibers and possible IBM). The percentage of stained fibers was significantly higher in IBM than PM for all three immunostains, but the markers varied in sensitivity and specificity. In particular, both LC3 and p62 were sensitive markers of IBM, but the tradeoff between sensitivity and specificity was smaller (and diagnostic utility thus greater) for LC3 than for p62. In contrast, TDP-43 immunopositivity was highly specific for IBM, but the sensitivity of this test was low, with definitive staining present in just 67% of IBM cases. Conclusions To differentiate IBM from PM, we thus recommend using a panel of LC3 and TDP-43 antibodies: the finding of <14% LC3-positive fibers helps exclude IBM, while >7% of TDP-43-positive fibers strongly supports a diagnosis of IBM. These data provide support for the hypothesis that disruption of autophagy and protein aggregation contribute to IBM pathogenesis. PMID:24252466

Comparative utility of LC3, p62 and TDP-43 immunohistochemistry in differentiation of inclusion body myositis from polymyositis and related inflammatory myopathies.

PubMed

Hiniker, Annie; Daniels, Brianne H; Lee, Han S; Margeta, Marta

2013-07-01

Inclusion body myositis (IBM) is a slowly progressive inflammatory myopathy of the elderly that does not show significant clinical improvement in response to steroid therapy. Distinguishing IBM from polymyositis (PM) is clinically important since PM is steroid-responsive; however, the two conditions can show substantial histologic overlap. We performed quantitative immunohistochemistry for (1) autophagic markers LC3 and p62 and (2) protein aggregation marker TDP-43 in 53 subjects with pathologically diagnosed PM, IBM, and two intermediate T cell-mediated inflammatory myopathies (polymyositis with COX-negative fibers and possible IBM). The percentage of stained fibers was significantly higher in IBM than PM for all three immunostains, but the markers varied in sensitivity and specificity. In particular, both LC3 and p62 were sensitive markers of IBM, but the tradeoff between sensitivity and specificity was smaller (and diagnostic utility thus greater) for LC3 than for p62. In contrast, TDP-43 immunopositivity was highly specific for IBM, but the sensitivity of this test was low, with definitive staining present in just 67% of IBM cases. To differentiate IBM from PM, we thus recommend using a panel of LC3 and TDP-43 antibodies: the finding of <14% LC3-positive fibers helps exclude IBM, while >7% of TDP-43-positive fibers strongly supports a diagnosis of IBM. These data provide support for the hypothesis that disruption of autophagy and protein aggregation contribute to IBM pathogenesis.

Schematic microscopic approach to the description of M1 transitions between mixed-symmetry and fully symmetric collective states in {gamma}-soft nuclei based on RPA-IBM boson mapping

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jolos, R. V.; Shirikova, N. Yu.; Voronov, V. V.

A schematic microscopic method is developed to calculate the M1 transition probabilities between the mixed-symmetry and the fully symmetric states in {gamma}-soft nuclei. The method is based on the random-phase approximation-interacting boson model (RPA-IBM) boson mapping of the most collective isoscalar boson. All other boson modes with higher excitation energies, including the mixed-symmetry boson, are described in the framework of RPA. As an example the M1 transition probabilities are calculated for the {sup 124-134}Xe isotopes and compared with the experimental data. The results agree well with the data for the ratio B(M1;1{sub ms}{sup +}{yields}2{sub 2}{sup +})/B(M1;1{sub ms}{sup +}{yields}0{sub 1}{sup +}).more » However, the calculated ratio B(M1;2{sub ms}{sup +}{yields}2{sub 1}{sup +})/B(M1;1{sub ms}{sup +}{yields}0{sub 1}{sup +}) shows a significantly weaker dependence on the mass number than the experimental data.« less

Corporate Mortality Files and Late Industrial Necropolitics.

PubMed

Little, Peter C

2017-10-05

This article critically examines the corporate production, archival politics, and socio-legal dimensions of corporate mortality files (CMFs), the largest corporate archive developed by IBM to systematically document industrial exposures and occupational health outcomes for electronics workers. I first provide a history of IBM's CMF project, which amounts to a comprehensive mortality record for IBM employees over the past 40 years. Next, I explore a recent case in Endicott, New York, birthplace of IBM, where the U.S. National Institute for Occupational Safety and Health studied IBM's CMFs for workers at IBM's former Endicott plant. Tracking the production of the IBM CMF, the strategic avoidance of this source of big data as evidence for determining a recent legal settlement, alongside local critiques of the IBM CMF project, the article develops what I call "late industrial necropolitics." © 2017 by the American Anthropological Association.

CWG - MUTUAL COUPLING PROGRAM FOR CIRCULAR WAVEGUIDE-FED APERTURE ARRAY (IBM PC VERSION)

NASA Technical Reports Server (NTRS)

Bailey, M. C.

1994-01-01

aperture combinations. The scattering matrix can then be used to determine the complex modal field amplitudes for each aperture with a specified array excitation. CWG is written in VAX FORTRAN for DEC VAX series computers running VMS (LAR-15236) and IBM PC series and compatible computers running MS-DOS (LAR-15226). It requires 360K of RAM for execution. To compile the source code for the PC version, the NDP Fortran compiler and linker will be required; however, the distribution medium for the PC version of CWG includes a sample MS-DOS executable which was created using NDP Fortran with the -vms compiler option. The standard distribution medium for the PC version of CWG is a 3.5 inch 1.44Mb MS-DOS format diskette. The standard distribution medium for the VAX version of CWG is a 1600 BPI 9track magnetic tape in DEC VAX BACKUP format. The VAX version is also available on a TK50 tape cartridge in DEC VAX BACKUP format. Both machine versions of CWG include an electronic version of the documentation in Microsoft Word for Windows format. CWG was developed in 1993 and is a copyrighted work with all copyright vested in NASA.

Increased aging in primary muscle cultures of sporadic inclusion-body myositis.

PubMed

Morosetti, Roberta; Broccolini, Aldobrando; Sancricca, Cristina; Gliubizzi, Carla; Gidaro, Teresa; Tonali, Pietro A; Ricci, Enzo; Mirabella, Massimiliano

2010-07-01

Ageing is thought to participate to the pathogenesis of sporadic inclusion-body myositis (s-IBM). Although the regenerative potential of s-IBM muscle is reduced in vivo, age-related abnormalities of satellite cells possibly accounting for the decline of muscle repair have not been demonstrated. Here we show that proliferation rate and clonogenicity of s-IBM myoblasts are significantly lower and doubling time is longer than normal age-matched controls, indicating that proliferative capacity of s-IBM muscles becomes exhausted earlier. Telomere shortening is detected in s-IBM cells suggesting premature senescence. Differently from controls, s-IBM myoblasts show increased active beta-catenin mainly localized within myonuclei, indicating active Wnt stimulation. After many rounds of muscle growth, only s-IBM myoblasts accumulate congophilic inclusions and immunoreactive Abeta(1-40) deposits. Therefore, s-IBM myoblasts seem to have a constitutively impaired regenerative capacity and the intrinsic property, upon sufficient aging in vitro, to accumulate Abeta. Our results might be valuable in understanding molecular mechanisms associated with muscle aging underlying the defective regeneration of s-IBM muscle and provide new clues for future therapeutic strategies. Copyright 2008 Elsevier Inc. All rights reserved.

Analysis and IbM simulation of the stages in bacterial lag phase: basis for an updated definition.

PubMed

Prats, Clara; Giró, Antoni; Ferrer, Jordi; López, Daniel; Vives-Rego, Josep

2008-05-07

The lag phase is the initial phase of a culture that precedes exponential growth and occurs when the conditions of the culture medium differ from the pre-inoculation conditions. It is usually defined by means of cell density because the number of individuals remains approximately constant or slowly increases, and it is quantified with the lag parameter lambda. The lag phase has been studied through mathematical modelling and by means of specific experiments. In recent years, Individual-based Modelling (IbM) has provided helpful insights into lag phase studies. In this paper, the definition of lag phase is thoroughly examined. Evolution of the total biomass and the total number of bacteria during lag phase is tackled separately. The lag phase lasts until the culture reaches a maximum growth rate both in biomass and cell density. Once in the exponential phase, both rates are constant over time and equal to each other. Both evolutions are split into an initial phase and a transition phase, according to their growth rates. A population-level mathematical model is presented to describe the transitional phase in cell density. INDividual DIScrete SIMulation (INDISIM) is used to check the outcomes of this analysis. Simulations allow the separate study of the evolution of cell density and total biomass in a batch culture, they provide a depiction of different observed cases in lag evolution at the individual-cell level, and are used to test the population-level model. The results show that the geometrical lag parameter lambda is not appropriate as a universal definition for the lag phase. Moreover, the lag phase cannot be characterized by a single parameter. For the studied cases, the lag phases of both the total biomass and the population are required to fully characterize the evolution of bacterial cultures. The results presented prove once more that the lag phase is a complex process that requires a more complete definition. This will be possible only after the phenomena

Analysis of habitat-selection rules using an individual-based model

Treesearch

Steven F. Railsback; Bret C. Harvey

2002-01-01

Abstract - Despite their promise for simulating natural complexity,individual-based models (IBMs) are rarely used for ecological research or resource management. Few IBMs have been shown to reproduce realistic patterns of behavior by individual organisms.To test our IBM of stream salmonids and draw conclusions about foraging theory,we analyzed the IBM ’s ability to...

Evaluation and construction of diagnostic criteria for inclusion body myositis

PubMed Central

Mammen, Andrew L.; Amato, Anthony A.; Weiss, Michael D.; Needham, Merrilee

2014-01-01

Objective: To use patient data to evaluate and construct diagnostic criteria for inclusion body myositis (IBM), a progressive disease of skeletal muscle. Methods: The literature was reviewed to identify all previously proposed IBM diagnostic criteria. These criteria were applied through medical records review to 200 patients diagnosed as having IBM and 171 patients diagnosed as having a muscle disease other than IBM by neuromuscular specialists at 2 institutions, and to a validating set of 66 additional patients with IBM from 2 other institutions. Machine learning techniques were used for unbiased construction of diagnostic criteria. Results: Twenty-four previously proposed IBM diagnostic categories were identified. Twelve categories all performed with high (≥97%) specificity but varied substantially in their sensitivities (11%–84%). The best performing category was European Neuromuscular Centre 2013 probable (sensitivity of 84%). Specialized pathologic features and newly introduced strength criteria (comparative knee extension/hip flexion strength) performed poorly. Unbiased data-directed analysis of 20 features in 371 patients resulted in construction of higher-performing data-derived diagnostic criteria (90% sensitivity and 96% specificity). Conclusions: Published expert consensus–derived IBM diagnostic categories have uniformly high specificity but wide-ranging sensitivities. High-performing IBM diagnostic category criteria can be developed directly from principled unbiased analysis of patient data. Classification of evidence: This study provides Class II evidence that published expert consensus–derived IBM diagnostic categories accurately distinguish IBM from other muscle disease with high specificity but wide-ranging sensitivities. PMID:24975859

INM Integrated Noise Model Version 2. Programmer’s Guide

DTIC Science & Technology

1979-09-01

cost, turnaround time, and system-dependent limitations. 3.2 CONVERSION PROBLEMS Item Item Item No. Desciption Category 1 BLOCK DATA Initialization IBM ...Restricted 2 Boolean Operations Differences Call Statement Parameters Extensions 4 Data Initialization IBM Restricted 5 ENTRY Differences 6 EQUIVALENCE...Machine Dependent 7 Format: A CDC Extension 8 Hollerith Strings IBM Restricted 9 Hollerith Variables IBM Restricted 10 Identifier Names CDC Extension

TWEAK in inclusion-body myositis muscle: possible pathogenic role of a cytokine inhibiting myogenesis.

PubMed

Morosetti, Roberta; Gliubizzi, Carla; Sancricca, Cristina; Broccolini, Aldobrando; Gidaro, Teresa; Lucchini, Matteo; Mirabella, Massimiliano

2012-04-01

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14 exert pleiotropic effects, including regulation of myogenesis. Sporadic inclusion-body myositis (IBM) is the most common muscle disease of the elderly population and leads to severe disability. IBM mesoangioblasts, different from mesoangioblasts in other inflammatory myopathies, display a myogenic differentiation defect. The objective of the present study was to investigate TWEAK-Fn14 expression in IBM and other inflammatory myopathies and explore whether TWEAK modulation affects myogenesis in IBM mesoangioblasts. TWEAK, Fn14, and NF-κB expression was assessed by immunohistochemistry and Western blot in cell samples from both muscle biopsies and primary cultures. Mesoangioblasts isolated from samples of IBM, dermatomyositis, polymyositis, and control muscles were treated with recombinant human TWEAK, Fn14-Fc chimera, and anti-TWEAK antibody. TWEAK-RNA interference was performed in IBM and dermatomyositis mesoangioblasts. TWEAK levels in culture media were determined by enzyme-linked immunosorbent assay. In IBM muscle, we found increased TWEAK-Fn14 expression. Increased levels of TWEAK were found in differentiation medium from IBM mesoangioblasts. Moreover, TWEAK inhibited myogenic differentiation of mesoangioblasts. Consistent with this evidence, TWEAK inhibition by Fn14-Fc chimera or short interfering RNA induced myogenic differentiation of IBM mesoangioblasts. We provide evidence that TWEAK is a negative regulator of human mesoangioblast differentiation. Dysregulation of the TWEAK-Fn14 axis in IBM muscle may induce progressive muscle atrophy and reduce activation and differentiation of muscle precursor cells. Copyright © 2012 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

Sleep disordered breathing in a cohort of patients with sporadic inclusion body myositis.

PubMed

Della Marca, Giacomo; Sancricca, Cristina; Losurdo, Anna; Di Blasi, Chiara; De Fino, Chiara; Morosetti, Roberta; Broccolini, Aldobrando; Testani, Elisa; Scarano, Emanuele; Servidei, Serenella; Mirabella, Massimiliano

2013-08-01

The aims of the study were: (1) to evaluate subjective sleep quality and daytime sleepiness in patients affected by sporadic inclusion-body myositis (IBM); (2) to define the sleep and sleep-related respiratory pattern in IBM patients. Thirteen consecutive adult patients affected by definite IBM were enrolled, six women and seven men, mean age 66.2 ± 11.1 years (range: 50-80). Diagnosis was based on clinical and muscle biopsy studies. All patients underwent subjective sleep evaluation (Pittsburgh Sleep Quality Index, PSQI and Epworth Sleepiness Scale, ESS), oro-pharingo-esophageal scintigraphy, pulmonary function tests, psychometric measures, anatomic evaluation of upper airways, and laboratory-based polysomnography. Findings in IBM patients were compared to those obtained from a control group of 25 healthy subjects (13 men and 12 women, mean age 61.9 ± 8.6 years). Disease duration was >10 years in all. Mean IBM severity score was 28.8 ± 5.4 (range 18-36). Dysphagia was present in 10 patients. Nine patients had PSQI scores ≥ 5; patients had higher mean PSQI score (IBM: 7.2 ± 4.7, CONTROLS: 2.76 ± 1.45, p=0.005); one patient (and no controls) had EES>9. Polysomnography showed that IBM patients, compared to controls, had lower sleep efficiency (IBM: 78.8 ± 12.0%, 94.0 ± 4.5%, p<0.001), more awakenings (IBM: 11.9 ± 11.0, CONTROLS: 5.2 ± 7.5, p=0.009) and increased nocturnal time awake (IBM: 121.2 ± 82.0 min., 46.12 ± 28.8 min., p=0.001). Seven Patients (and no controls) had polysomnographic findings consistent with sleep disordered breathing (SDB). Data suggest that sleep disruption, and in particular SDB, might be highly prevalent in IBM. Data indicate that IBM patients have poor sleep and high prevalence of SDB. Copyright © 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Avatar DNA Nanohybrid System in Chip-on-a-Phone

NASA Astrophysics Data System (ADS)

Park, Dae-Hwan; Han, Chang Jo; Shul, Yong-Gun; Choy, Jin-Ho

2014-05-01

Long admired for informational role and recognition function in multidisciplinary science, DNA nanohybrids have been emerging as ideal materials for molecular nanotechnology and genetic information code. Here, we designed an optical machine-readable DNA icon on microarray, Avatar DNA, for automatic identification and data capture such as Quick Response and ColorZip codes. Avatar icon is made of telepathic DNA-DNA hybrids inscribed on chips, which can be identified by camera of smartphone with application software. Information encoded in base-sequences can be accessed by connecting an off-line icon to an on-line web-server network to provide message, index, or URL from database library. Avatar DNA is then converged with nano-bio-info-cogno science: each building block stands for inorganic nanosheets, nucleotides, digits, and pixels. This convergence could address item-level identification that strengthens supply-chain security for drug counterfeits. It can, therefore, provide molecular-level vision through mobile network to coordinate and integrate data management channels for visual detection and recording.

Avatar DNA Nanohybrid System in Chip-on-a-Phone

PubMed Central

Park, Dae-Hwan; Han, Chang Jo; Shul, Yong-Gun; Choy, Jin-Ho

2014-01-01

Long admired for informational role and recognition function in multidisciplinary science, DNA nanohybrids have been emerging as ideal materials for molecular nanotechnology and genetic information code. Here, we designed an optical machine-readable DNA icon on microarray, Avatar DNA, for automatic identification and data capture such as Quick Response and ColorZip codes. Avatar icon is made of telepathic DNA-DNA hybrids inscribed on chips, which can be identified by camera of smartphone with application software. Information encoded in base-sequences can be accessed by connecting an off-line icon to an on-line web-server network to provide message, index, or URL from database library. Avatar DNA is then converged with nano-bio-info-cogno science: each building block stands for inorganic nanosheets, nucleotides, digits, and pixels. This convergence could address item-level identification that strengthens supply-chain security for drug counterfeits. It can, therefore, provide molecular-level vision through mobile network to coordinate and integrate data management channels for visual detection and recording. PMID:24824876

Update in inclusion body myositis

PubMed Central

Machado, Pedro; Brady, Stefen; Hanna, Michael G.

2013-01-01

Purpose of review The purpose of this study is to review recent scientific advances relating to the natural history, cause, treatment and serum and imaging biomarkers of inclusion body myositis (IBM). Recent findings Several theories regarding the aetiopathogenesis of IBM are being explored and new therapeutic approaches are being investigated. New diagnostic criteria have been proposed, reflecting the knowledge that the diagnostic pathological findings may be absent in patients with clinically typical IBM. The role of MRI in IBM is expanding and knowledge about pathological biomarkers is increasing. The recent description of autoantibodies to cytosolic 5′ nucleotidase 1A in patients with IBM is a potentially important advance that may aid early diagnosis and provides new evidence regarding the role of autoimmunity in IBM. Summary IBM remains an enigmatic and often misdiagnosed disease. The pathogenesis of the disease is still not fully understood. To date, pharmacological treatment trials have failed to show clear efficacy. Future research should continue to focus on improving understanding of the pathophysiological mechanisms of the disease and on the identification of reliable and sensitive outcome measures for clinical trials. IBM is a rare disease and international multicentre collaboration for trials is important to translate research advances into improved patient outcomes. PMID:24067381

Sporadic inclusion body myositis: the genetic contributions to the pathogenesis

PubMed Central

2014-01-01

Sporadic inclusion body myositis (sIBM) is the commonest idiopathic inflammatory muscle disease in people over 50 years old. It is characterized by slowly progressive muscle weakness and atrophy, with typical pathological changes of inflammation, degeneration and mitochondrial abnormality in affected muscle fibres. The cause(s) of sIBM are still unknown, but are considered complex, with the contribution of multiple factors such as environmental triggers, ageing and genetic susceptibility. This review summarizes the current understanding of the genetic contributions to sIBM and provides some insights for future research in this mysterious disease with the advantage of the rapid development of advanced genetic technology. An international sIBM genetic study is ongoing and whole-exome sequencing will be applied in a large cohort of sIBM patients with the aim of unravelling important genetic risk factors for sIBM. PMID:24948216

Fracture Mechanics Analysis of Single and Double Rows of Fastener Holes Loaded in Bearing

DTIC Science & Technology

1976-04-01

the following subprograms for execution: 1. ASRL FEABL-2 subroutines ASMLTV, ASMSUB, BCON, FACT, ORK, QBACK, SETUP, SIMULQ, STACON, and XTRACT. 2. IBM ...based on program code generated by IBM FORTRAN-G1 and FORTRAN-H compilers, with demonstration runs made on an IBM 370/168 computer. Programs SROW and...DROW are supplied ready to execute on systems with IBM -standard FORTRAN unit members for the card reader (unit 5) and line printer (unit 6). The

The UCLA MEDLARS Computer System *

PubMed Central

Garvis, Francis J.

1966-01-01

Under a subcontract with UCLA the Planning Research Corporation has changed the MEDLARS system to make it possible to use the IBM 7094/7040 direct-couple computer instead of the Honeywell 800 for demand searches. The major tasks were the rewriting of the programs in COBOL and copying of the stored information on the narrower tapes that IBM computers require. (In the future NLM will copy the tapes for IBM computer users.) The differences in the software required by the two computers are noted. Major and costly revisions would be needed to adapt the large MEDLARS system to the smaller IBM 1401 and 1410 computers. In general, MEDLARS is transferrable to other computers of the IBM 7000 class, the new IBM 360, and those of like size, such as the CDC 1604 or UNIVAC 1108, although additional changes are necessary. Potential future improvements are suggested. PMID:5901355

Sporadic Inclusion Body Myositis: Possible pathogenesis inferred from biomarkers

PubMed Central

Weihl, Conrad C.; Pestronk, Alan

2013-01-01

Purpose of review The relevance of proteins that accumulate and aggregate in the muscle fibers of patients with sporadic inclusion body myositis (sIBM) is unknown. Many of these proteins also aggregate in other disorders, including Alzheimer’s disease, leading to speculation that sIBM pathogenesis has similarities to neurodegenerative disorders. Our review will discuss current studies on these protein biomarkers and any utility in sIBM diagnosis. Recent findings Two “classical” components of sIBM aggregates (Aβ and phospho-tau) have been re-evaluated. Three additional components of aggregates (TDP-43, p62, and LC3) have been identified. The sensitivity and specificity of these biomarkers has been explored. Two studies suggest that TDP-43 may have clinical utility in distinguishing sIBM from other inflammatory myopathies. Summary The fact that sIBM muscle accumulates multiple protein aggregates with no single protein appearing in every sIBM patient biopsy suggests that it is not presently possible to place pathogenic blame on any single protein (i.e. Aβ or TDP-43). Instead changes in protein homeostasis may lead to the accumulation of different proteins that have a propensity to aggregate in skeletal muscle. Therapies aimed at improving protein homeostasis, instead of targeting a specific protein that may or may not accumulate in all sIBM patients, could be useful future strategies for this devastating and enigmatic disorder. PMID:20664349

Automatic Determination of the Need for Intravenous Contrast in Musculoskeletal MRI Examinations Using IBM Watson's Natural Language Processing Algorithm.

PubMed

Trivedi, Hari; Mesterhazy, Joseph; Laguna, Benjamin; Vu, Thienkhai; Sohn, Jae Ho

2018-04-01

Magnetic resonance imaging (MRI) protocoling can be time- and resource-intensive, and protocols can often be suboptimal dependent upon the expertise or preferences of the protocoling radiologist. Providing a best-practice recommendation for an MRI protocol has the potential to improve efficiency and decrease the likelihood of a suboptimal or erroneous study. The goal of this study was to develop and validate a machine learning-based natural language classifier that can automatically assign the use of intravenous contrast for musculoskeletal MRI protocols based upon the free-text clinical indication of the study, thereby improving efficiency of the protocoling radiologist and potentially decreasing errors. We utilized a deep learning-based natural language classification system from IBM Watson, a question-answering supercomputer that gained fame after challenging the best human players on Jeopardy! in 2011. We compared this solution to a series of traditional machine learning-based natural language processing techniques that utilize a term-document frequency matrix. Each classifier was trained with 1240 MRI protocols plus their respective clinical indications and validated with a test set of 280. Ground truth of contrast assignment was obtained from the clinical record. For evaluation of inter-reader agreement, a blinded second reader radiologist analyzed all cases and determined contrast assignment based on only the free-text clinical indication. In the test set, Watson demonstrated overall accuracy of 83.2% when compared to the original protocol. This was similar to the overall accuracy of 80.2% achieved by an ensemble of eight traditional machine learning algorithms based on a term-document matrix. When compared to the second reader's contrast assignment, Watson achieved 88.6% agreement. When evaluating only the subset of cases where the original protocol and second reader were concordant (n = 251), agreement climbed further to 90.0%. The classifier was

Accelerating Climate and Weather Simulations through Hybrid Computing

NASA Technical Reports Server (NTRS)

Zhou, Shujia; Cruz, Carlos; Duffy, Daniel; Tucker, Robert; Purcell, Mark

2011-01-01

Unconventional multi- and many-core processors (e.g. IBM (R) Cell B.E.(TM) and NVIDIA (R) GPU) have emerged as effective accelerators in trial climate and weather simulations. Yet these climate and weather models typically run on parallel computers with conventional processors (e.g. Intel, AMD, and IBM) using Message Passing Interface. To address challenges involved in efficiently and easily connecting accelerators to parallel computers, we investigated using IBM's Dynamic Application Virtualization (TM) (IBM DAV) software in a prototype hybrid computing system with representative climate and weather model components. The hybrid system comprises two Intel blades and two IBM QS22 Cell B.E. blades, connected with both InfiniBand(R) (IB) and 1-Gigabit Ethernet. The system significantly accelerates a solar radiation model component by offloading compute-intensive calculations to the Cell blades. Systematic tests show that IBM DAV can seamlessly offload compute-intensive calculations from Intel blades to Cell B.E. blades in a scalable, load-balanced manner. However, noticeable communication overhead was observed, mainly due to IP over the IB protocol. Full utilization of IB Sockets Direct Protocol and the lower latency production version of IBM DAV will reduce this overhead.

MyoD expression restores defective myogenic differentiation of human mesoangioblasts from inclusion-body myositis muscle.

PubMed

Morosetti, Roberta; Mirabella, Massimiliano; Gliubizzi, Carla; Broccolini, Aldobrando; De Angelis, Luciana; Tagliafico, Enrico; Sampaolesi, Maurilio; Gidaro, Teresa; Papacci, Manuela; Roncaglia, Enrica; Rutella, Sergio; Ferrari, Stefano; Tonali, Pietro Attilio; Ricci, Enzo; Cossu, Giulio

2006-11-07

Inflammatory myopathies (IM) are acquired diseases of skeletal muscle comprising dermatomyositis (DM), polymyositis (PM), and inclusion-body myositis (IBM). Immunosuppressive therapies, usually beneficial for DM and PM, are poorly effective in IBM. We report the isolation and characterization of mesoangioblasts, vessel-associated stem cells, from diagnostic muscle biopsies of IM. The number of cells isolated, proliferation rate and lifespan, markers expression, and ability to differentiate into smooth muscle do not differ among normal and IM mesoangioblasts. At variance with normal, DM and PM mesoangioblasts, cells isolated from IBM, fail to differentiate into skeletal myotubes. These data correlate with lack in connective tissue of IBM muscle of alkaline phosphatase (ALP)-positive cells, conversely dramatically increased in PM and DM. A myogenic inhibitory basic helix-loop-helix factor B3 is highly expressed in IBM mesoangioblasts. Indeed, silencing this gene or overexpressing MyoD rescues the myogenic defect of IBM mesoangioblasts, opening novel cell-based therapeutic strategies for this crippling disorder.

MyoD expression restores defective myogenic differentiation of human mesoangioblasts from inclusion-body myositis muscle

PubMed Central

Morosetti, Roberta; Mirabella, Massimiliano; Gliubizzi, Carla; Broccolini, Aldobrando; De Angelis, Luciana; Tagliafico, Enrico; Sampaolesi, Maurilio; Gidaro, Teresa; Papacci, Manuela; Roncaglia, Enrica; Rutella, Sergio; Ferrari, Stefano; Tonali, Pietro Attilio; Ricci, Enzo; Cossu, Giulio

2006-01-01

Inflammatory myopathies (IM) are acquired diseases of skeletal muscle comprising dermatomyositis (DM), polymyositis (PM), and inclusion-body myositis (IBM). Immunosuppressive therapies, usually beneficial for DM and PM, are poorly effective in IBM. We report the isolation and characterization of mesoangioblasts, vessel-associated stem cells, from diagnostic muscle biopsies of IM. The number of cells isolated, proliferation rate and lifespan, markers expression, and ability to differentiate into smooth muscle do not differ among normal and IM mesoangioblasts. At variance with normal, DM and PM mesoangioblasts, cells isolated from IBM, fail to differentiate into skeletal myotubes. These data correlate with lack in connective tissue of IBM muscle of alkaline phosphatase (ALP)-positive cells, conversely dramatically increased in PM and DM. A myogenic inhibitory basic helix–loop–helix factor B3 is highly expressed in IBM mesoangioblasts. Indeed, silencing this gene or overexpressing MyoD rescues the myogenic defect of IBM mesoangioblasts, opening novel cell-based therapeutic strategies for this crippling disorder. PMID:17077152

Simple model for deriving sdg interacting boson model Hamiltonians: 150Nd example

NASA Astrophysics Data System (ADS)

Devi, Y. D.; Kota, V. K. B.

1993-07-01

A simple and yet useful model for deriving sdg interacting boson model (IBM) Hamiltonians is to assume that single-boson energies derive from identical particle (pp and nn) interactions and proton, neutron single-particle energies, and that the two-body matrix elements for bosons derive from pn interaction, with an IBM-2 to IBM-1 projection of the resulting p-n sdg IBM Hamiltonian. The applicability of this model in generating sdg IBM Hamiltonians is demonstrated, using a single-j-shell Otsuka-Arima-Iachello mapping of the quadrupole and hexadecupole operators in proton and neutron spaces separately and constructing a quadrupole-quadrupole plus hexadecupole-hexadecupole Hamiltonian in the analysis of the spectra, B(E2)'s, and E4 strength distribution in the example of 150Nd.

Effects of an Appearance-Focused Interpretation Training Intervention on Eating Disorder Symptoms.

PubMed

Summers, Berta J; Cougle, Jesse R

2018-03-13

Previous research suggests that computerized interpretation bias modification (IBM) techniques may be useful for modifying thoughts and behaviours relevant to eating pathology; however, little is known about the utility of IBM for decreasing specific eating disorder (ED) symptoms (e.g. bulimia, drive for thinness). The current study sought to further examine the utility of IBM for ED symptoms via secondary analyses of an examination of IBM for individuals with elevated body dysmorphic disorder (BDD) symptoms (see Summers and Cougle, 2016), as these disorders are both characterized by threat interpretation biases of ambiguous appearance-related information. We recruited 41 participants for a randomized trial comparing four sessions of IBM aimed at modifying problematic social and appearance-related threat interpretation biases with a placebo control training (PC). At 1-week post-treatment, and relative to the PC, the IBM group reported greater reductions in negative/threat interpretations of ambiguous information in favour of positive/benign biases. Furthermore, among individuals with high pre-treatment bulimia symptoms, IBM yielded greater reductions in bulimia symptoms compared with PC at post-treatment. No treatment effects were observed on drive for thinness symptoms. The current study suggests that cognitive interventions for individuals with primary BDD symptoms may improve co-occurring ED symptoms such as bulimia.

Rare variants in SQSTM1 and VCP genes and risk of sporadic inclusion body myositis.

PubMed

Gang, Qiang; Bettencourt, Conceição; Machado, Pedro M; Brady, Stefen; Holton, Janice L; Pittman, Alan M; Hughes, Deborah; Healy, Estelle; Parton, Matthew; Hilton-Jones, David; Shieh, Perry B; Needham, Merrilee; Liang, Christina; Zanoteli, Edmar; de Camargo, Leonardo Valente; De Paepe, Boel; De Bleecker, Jan; Shaibani, Aziz; Ripolone, Michela; Violano, Raffaella; Moggio, Maurizio; Barohn, Richard J; Dimachkie, Mazen M; Mora, Marina; Mantegazza, Renato; Zanotti, Simona; Singleton, Andrew B; Hanna, Michael G; Houlden, Henry

2016-11-01

Genetic factors have been suggested to be involved in the pathogenesis of sporadic inclusion body myositis (sIBM). Sequestosome 1 (SQSTM1) and valosin-containing protein (VCP) are 2 key genes associated with several neurodegenerative disorders but have yet to be thoroughly investigated in sIBM. A candidate gene analysis was conducted using whole-exome sequencing data from 181 sIBM patients, and whole-transcriptome expression analysis was performed in patients with genetic variants of interest. We identified 6 rare missense variants in the SQSTM1 and VCP in 7 sIBM patients (4.0%). Two variants, the SQSTM1 p.G194R and the VCP p.R159C, were significantly overrepresented in this sIBM cohort compared with controls. Five of these variants had been previously reported in patients with degenerative diseases. The messenger RNA levels of major histocompatibility complex genes were upregulated, this elevation being more pronounced in SQSTM1 patient group. We report for the first time potentially pathogenic SQSTM1 variants and expand the spectrum of VCP variants in sIBM. These data suggest that defects in neurodegenerative pathways may confer genetic susceptibility to sIBM and reinforce the mechanistic overlap in these neurodegenerative disorders. Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.

Reviews.

ERIC Educational Resources Information Center

Newland, Robert J.; And Others

1988-01-01

Reviews four organic chemistry computer programs and three books. Software includes: (1) NMR Simulator 7--for IBM or Macintosh, (2) Nucleic Acid Structure and Synthesis--for IBM, (3) Molecular Design Editor--for Apple II, and (4) Synthetic Adventure--for Apple II and IBM. Book topics include physical chemistry, polymer pioneers, and the basics of…

77 FR 41720 - Hazardous Waste Management System; Identification and Listing of Hazardous Waste; Proposed Exclusion

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-16

... delist? B. How does IBM generate the waste? C. How did IBM sample and analyze the petitioned waste? D..., thickened/conditioned, and pressed to generate the F006 waste stream. C. How did IBM sample and analyze the... the volatiles and semi-volatiles samples were non- detect. E. How did EPA evaluate the risk of...

Targeting protein homeostasis in sporadic inclusion body myositis.

PubMed

Ahmed, Mhoriam; Machado, Pedro M; Miller, Adrian; Spicer, Charlotte; Herbelin, Laura; He, Jianghua; Noel, Janelle; Wang, Yunxia; McVey, April L; Pasnoor, Mamatha; Gallagher, Philip; Statland, Jeffrey; Lu, Ching-Hua; Kalmar, Bernadett; Brady, Stefen; Sethi, Huma; Samandouras, George; Parton, Matt; Holton, Janice L; Weston, Anne; Collinson, Lucy; Taylor, J Paul; Schiavo, Giampietro; Hanna, Michael G; Barohn, Richard J; Dimachkie, Mazen M; Greensmith, Linda

2016-03-23

Sporadic inclusion body myositis (sIBM) is the commonest severe myopathy in patients more than 50 years of age. Previous therapeutic trials have targeted the inflammatory features of sIBM but all have failed. Because protein dyshomeostasis may also play a role in sIBM, we tested the effects of targeting this feature of the disease. Using rat myoblast cultures, we found that up-regulation of the heat shock response with arimoclomol reduced key pathological markers of sIBM in vitro. Furthermore, in mutant valosin-containing protein (VCP) mice, which develop an inclusion body myopathy, treatment with arimoclomol ameliorated disease pathology and improved muscle function. We therefore evaluated arimoclomol in an investigator-led, randomized, double-blind, placebo-controlled, proof-of-concept trial in sIBM patients and showed that arimoclomol was safe and well tolerated. Although arimoclomol improved some IBM-like pathology in the mutant VCP mouse, we did not see statistically significant evidence of efficacy in the proof-of-concept patient trial. Copyright © 2016, American Association for the Advancement of Science.

Targeting Protein Homeostasis in Sporadic Inclusion Body Myositis

PubMed Central

Ahmed, Mhoriam; Machado, Pedro M.; Miller, Adrian; Spicer, Charlotte; Herbelin, Laura; He, Jianghua; Noel, Janelle; Wang, Yunxia; McVey, April L.; Pasnoor, Mamatha; Gallagher, Philip; Statland, Jeffrey; Lu, Ching-Hua; Kalmar, Bernadett; Brady, Stefen; Sethi, Huma; Samandouras, George; Parton, Matt; Holton, Janice L.; Weston, Anne; Collinson, Lucy; Taylor, J. Paul; Schiavo, Giampietro; Hanna, Michael G.; Barohn, Richard J.; Dimachkie, Mazen M.; Greensmith, Linda

2016-01-01

Sporadic inclusion body myositis (sIBM) is the commonest severe myopathy in patients over age 50. Previous therapeutic trials have targeted the inflammatory features of sIBM, but all have failed. Since protein dyshomeostasis may also play a role in sIBM, we tested the effects of targeting this feature of the disease. Using rat myoblast cultures, we found that up-regulation of the heat shock response with Arimoclomol reduced key pathological markers of sIBM in vitro. Furthermore, in mutant valosin-containing protein VCP mice, which develop an inclusion body myopathy (IBM), treatment with Arimoclomol ameliorated disease pathology and improved muscle function. We therefore evaluated the safety and tolerability of Arimoclomol in an investigator-lead, randomised, double-blind, placebo-controlled, proof-of-concept patient trial and gathered exploratory efficacy data which showed that Arimoclomol was safe and well tolerated. Although Arimoclomol improved some IBM-like pathology in vitro and in vivo in the mutant VCP mouse, we did not see statistically significant evidence of efficacy in this proof of concept patient trial. PMID:27009270

Computer Associates International, CA-ACF2/VM Release 3.1

DTIC Science & Technology

1987-09-09

Associates CA-ACF2/VM Bibliography International Business Machines Corporation, IBM Virtual Machine/Directory Maintenance Program Logic Manual...publication number LY20-0889 International Business Machines International Business Machines Corporation, IBM System/370 Principles of Operation...publication number GA22-7000 International Business Machines Corporation, IBM Virtual Machine/Directory Maintenance Installation and System Administrator’s

Inclusion body myositis.

PubMed

Dimachkie, Mazen M; Barohn, Richard J

2014-08-01

The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of rare disorders that share many similarities. In addition to sporadic inclusion body myositis (IBM), these include dermatomyositis, polymyositis, and autoimmune necrotizing myopathy. IBM is the most common IIM after age 50 years. Muscle histopathology shows endomysial inflammatory exudates surrounding and invading nonnecrotic muscle fibers often accompanied by rimmed vacuoles and protein deposits. It is likely that IBM is has a prominent degenerative component. This article reviews the evolution of knowledge in IBM, with emphasis on recent developments in the field, and discusses ongoing clinical trials. Copyright © 2014 Elsevier Inc. All rights reserved.

Paired Helical Filaments of Inclusion-Body Myositis Muscle Contain RNA and Survival Motor Neuron Protein

PubMed Central

Broccolini, Aldobrando; Engel, W. King; Alvarez, Renate B.; Askanas, Valerie

2000-01-01

Sporadic inclusion-body myositis (s-IBM) is the most common progressive muscle disease of older persons. Pathologically, the muscle biopsy manifests various degrees of inflammation and specific vacuolar degeneration of muscle fibers characterized by paired helical filaments (PHFs) composed of phosphorylated tau. IBM vacuolated fibers also contain accumulations of several other Alzheimer-characteristic proteins. Molecular mechanisms leading to formation of the PHFs and accumulations of proteins in IBM muscle are not known. We report that the abnormal muscle fibers of IBM contained (i) acridine-orange-positive RNA inclusions that colocalized with the immunoreactivity of phosphorylated tau and (ii) survival motor neuron protein immunoreactive inclusions, which by immuno-electron microscopy were confined to paired helical filaments. This study demonstrates two novel components of the IBM paired helical filaments, which may lead to better understanding of their pathogenesis. PMID:10751338

Paired helical filaments of inclusion-body myositis muscle contain RNA and survival motor neuron protein.

PubMed

Broccolini, A; Engel, W K; Alvarez, R B; Askanas, V

2000-04-01

Sporadic inclusion-body myositis (s-IBM) is the most common progressive muscle disease of older persons. Pathologically, the muscle biopsy manifests various degrees of inflammation and specific vacuolar degeneration of muscle fibers characterized by paired helical filaments (PHFs) composed of phosphorylated tau. IBM vacuolated fibers also contain accumulations of several other Alzheimer-characteristic proteins. Molecular mechanisms leading to formation of the PHFs and accumulations of proteins in IBM muscle are not known. We report that the abnormal muscle fibers of IBM contained (i) acridine-orange-positive RNA inclusions that colocalized with the immunoreactivity of phosphorylated tau and (ii) survival motor neuron protein immunoreactive inclusions, which by immuno-electron microscopy were confined to paired helical filaments. This study demonstrates two novel components of the IBM paired helical filaments, which may lead to better understanding of their pathogenesis.

Best kept secrets ... First Coast Systems, Inc. (FCS).

PubMed

Andrew, W F

1991-04-01

The FCS/APaCS system is a viable option for small-to medium-size hospitals (up to 400 beds). The table-driven system takes full advantage of IBM AS/400 computer architecture. A comprehensive application set, provided in an integrated database environment, is adaptable to multi-facility environments. Price/performance appears to be competitive. Commitment to IBM AS/400 environment assures cost-effective hardware platforms backed by IBM support and resources. As an IBM Health Industry Business Partner, FCS (and its clients) benefits from IBM's well-known commitment to quality and service. Corporate emphasis on user involvement and satisfaction, along with a commitment to quality and service for the APaCS systems, assures clients of "leading edge" capabilities in this evolutionary healthcare delivery environment. FCS/APaCS will be a strong contender in selected marketing environments.

Taste function assessed by electrogustometry in burning mouth syndrome: a case-control study.

PubMed

Braud, A; Descroix, V; Ungeheuer, M-N; Rougeot, C; Boucher, Y

2017-04-01

Idiopathic burning mouth syndrome (iBMS) is characterized by oral persistent pain without any clinical or biological abnormality. The aim of this study was to evaluate taste function in iBMS subjects and healthy controls. Electrogustometric thresholds (EGMt) were recorded in 21 iBMS patients and 21 paired-matched controls at nine loci of the tongue assessing fungiform and foliate gustatory papillae function. Comparison of EGMt was performed using the nonparametric Wilcoxon signed-rank test. A correlation between EGMt and self-perceived pain intensity assessed using a visual analogic scale (VAS) was analyzed with the Spearman coefficient. The level of significance was fixed at P < 0.05. Mean EGMt were significantly increased with iBMS for right side of the dorsum of the tongue and right lateral side of the tongue (P < 0.05). In the iBMS group, VAS scores were significantly correlated to EGMt at the tip of the tongue (r = -0.59; P < 0.05) and at the right and left lateral sides of the tongue (respectively, r = -0.49 and r = -0.47; P < 0.05). These data depicted impaired taste sensitivity in iBMS patients within fungiform and foliate taste bud fields and support potent gustatory/nociceptive interaction in iBMS. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Assessment of DoD and Industry Networks for Computer Aided Logistics Support (CALS) Telecommunications.

DTIC Science & Technology

1987-06-01

International Business Machines ( IBM ) Corporation compatible synchronous terminals (2780/3780/327X), and the Federal Data Corporation (FDC) has developed...the interfaces for Burroughs look-alike asynchronous and synchronous terminals. Basically, this means that the IBM and Burroughs protocols are...and other vendor computers, such as IBM , UNIVAC, and Honeywell. The Navy has developed file transfer capabilities between Tandem and Burroughs. These

PubMed Central

SERDAROGLU OFLAZER, P.; DEYMEER, F.; PARMAN, Y.

2011-01-01

SUMMARY In a muscle biopsy based study, only 9 out of 5450 biopsy samples, received from all parts of greater Istanbul area, had typical clinical and most suggestive light microscopic sporadic-inclusion body myositis (s-IBM) findings. Two other patients with and ten further patients without characteristic light microscopic findings had referring diagnosis of s-IBM. As the general and the ageadjusted populations of Istanbul in 2010 were 13.255.685 and 2.347.300 respectively, the calculated corresponding ‘estimated prevalences' of most suggestive s-IBM in the Istanbul area were 0.679 X 10-6 and 3.834 X 10-6. Since Istanbul receives heavy migration from all regions of Turkey and ours is the only muscle pathology laboratory in Istanbul, projection of these figures to the Turkish population was considered to be reasonable and an estimate of the prevalence of s-IBM in Turkey was obtained. The calculated ‘estimated prevalence' of s-IBM in Turkey is lower than the previously reported rates from other countries. The wide variation in the prevalence rates of s-IBM may reflect different genetic, immunogenetic or environmental factors in different populations. PMID:21842592

Science and technology integration for increased human potential and societal outcomes.

PubMed

Roco, Mihail C

2004-05-01

Unifying science based on the material unity of nature at the nanoscale provides a new foundation for knowledge, innovation, and integration of technology. Revolutionary and synergistic advances at the interfaces between previously separated fields of science, engineering and areas of relevance are ready to create nano-bio-info-cogno (NBIC) transforming tools. Developments in systems approach, mathematics, and computation in conjunction with NBIC allow us to understand the natural world and scientific research as closely coupled, complex, hierarchical entities. At this unique moment of scientific and technical achievement, improvement of human performance at individual and group levels, as well as development of suitable revolutionary products, becomes possible and these are primary goals for converging new technologies. NBIC addresses long-term advances in key areas of human activity, including working, learning, aging, group interaction, organizations, and human evolution ((Roco and Bainbridge, 2003)). Fundamentally new tools, technologies, and products will be integrated into individual and social human architecture. This introductory chapter of the Annals outlines research and education trends, funding activities, and the potential of development of revolutionary products and services.

Survey of Mass Storage Systems

DTIC Science & Technology

1975-09-01

software that Pre- cision Instruments can provide. System Name: IBM 3850 Mass Storage System Manufacturer and Location: International Business Machines...34 Datamation, pp. 52-58, October 1973. 15 17. International Business Machines, IBM 3850 Mass Storage System Facts Folder, White Plains, NY, n.d. 18... International Business Machines, Introduction to the IBM 3850 Mass Storage System (MSS), White Plains, NY, n.d. 19. International Business Machines

Intercomparison of terrain-following coordinate transformation and immersed boundary methods in large-eddy simulation of wind fields over complex terrain

NASA Astrophysics Data System (ADS)

Fang, Jiannong; Porté-Agel, Fernando

2016-09-01

Accurate modeling of complex terrain, especially steep terrain, in the simulation of wind fields remains a challenge. It is well known that the terrain-following coordinate transformation method (TFCT) generally used in atmospheric flow simulations is restricted to non-steep terrain with slope angles less than 45 degrees. Due to the advantage of keeping the basic computational grids and numerical schemes unchanged, the immersed boundary method (IBM) has been widely implemented in various numerical codes to handle arbitrary domain geometry including steep terrain. However, IBM could introduce considerable implementation errors in wall modeling through various interpolations because an immersed boundary is generally not co-located with a grid line. In this paper, we perform an intercomparison of TFCT and IBM in large-eddy simulation of a turbulent wind field over a three-dimensional (3D) hill for the purpose of evaluating the implementation errors in IBM. The slopes of the three-dimensional hill are not steep and, therefore, TFCT can be applied. Since TFCT is free from interpolation-induced implementation errors in wall modeling, its results can serve as a reference for the evaluation so that the influence of errors from wall models themselves can be excluded. For TFCT, a new algorithm for solving the pressure Poisson equation in the transformed coordinate system is proposed and first validated for a laminar flow over periodic two-dimensional hills by comparing with a benchmark solution. For the turbulent flow over the 3D hill, the wind-tunnel measurements used for validation contain both vertical and horizontal profiles of mean velocities and variances, thus allowing an in-depth comparison of the numerical models. In this case, TFCT is expected to be preferable to IBM. This is confirmed by the presented results of comparison. It is shown that the implementation errors in IBM lead to large discrepancies between the results obtained by TFCT and IBM near the surface

Anesthetic Considerations of Sporadic Inclusion Body Myositis in an Elderly Man With Orthopedic Trauma.

PubMed

Steck, Dominik T; Choi, Christine; Gollapudy, Suneeta; Pagel, Paul S

2016-04-01

Sporadic inclusion body myositis (IBM) is an inflammatory myopathy characterized by progressive asymmetric extremity weakness, oropharyngeal dysphagia, and the potential for exaggerated sensitivity to neuromuscular blockers and respiratory compromise. The authors describe their management of a patient with IBM undergoing urgent orthopedic surgery. An 81-year-old man with IBM suffered a left intertrochanteric femoral fracture after falling down stairs. His IBM caused progressive left proximal lower extremity, bilateral distal upper extremity weakness (left > right), and oropharyngeal dysphagia (solid food, pills). He denied dyspnea, exercise intolerance, and a history of aspiration. Because respiratory insufficiency resulting from diaphragmatic dysfunction and prolonged duration of action of neuromuscular blockers may occur in IBM, the authors avoided using a neuromuscular blocker. After applying cricoid pressure, anesthesia was induced using intravenous lidocaine, propofol, remifentanil followed by manual ventilation with inhaled sevoflurane in oxygen. Endotracheal intubation was accomplished without difficulty; anesthesia was then maintained using remifentanil and sevoflurane. The fracture was repaired with a trochanteric femoral nail. The patient was extubated without difficulty and made an uneventful recovery. In summary, there is a lack of consensus about the use of neuromuscular blockers in patients with IBM. The authors avoided these drugs and were able to easily secure the patient's airway and maintain adequate muscle relaxation using a balanced sevoflurane-remifentanil anesthetic. Clinical trials are necessary to define the pharmacology of neuromuscular blockers in patients with IBM and determine whether use of these drugs contributes to postoperative respiratory insufficiency in these vulnerable patients.

Individual-based modeling of ecological and evolutionary processes

USGS Publications Warehouse

DeAngelis, Donald L.; Mooij, Wolf M.

2005-01-01

Individual-based models (IBMs) allow the explicit inclusion of individual variation in greater detail than do classical differential-equation and difference-equation models. Inclusion of such variation is important for continued progress in ecological and evolutionary theory. We provide a conceptual basis for IBMs by describing five major types of individual variation in IBMs: spatial, ontogenetic, phenotypic, cognitive, and genetic. IBMs are now used in almost all subfields of ecology and evolutionary biology. We map those subfields and look more closely at selected key papers on fish recruitment, forest dynamics, sympatric speciation, metapopulation dynamics, maintenance of diversity, and species conservation. Theorists are currently divided on whether IBMs represent only a practical tool for extending classical theory to more complex situations, or whether individual-based theory represents a radically new research program. We feel that the tension between these two poles of thinking can be a source of creativity in ecology and evolutionary theory.

β4 systematics in rare-earth and actinide nuclei: sdg interacting boson model description

NASA Astrophysics Data System (ADS)

Devi, Y. D.; Kota, V. K. B.

1992-07-01

The observed variation of hexadecupole deformation parameter β4 with mass number A in rare-earth and actinide nuclei is studied in the sdg interacting boson model (IBM) using single j-shell Otsuka-Arima-Iachello mapped and IBM-2 to IBM-1 projected hexadecupole transition operator together with SUsdg(3) and SUsdg(5) coherent states. The SUsdg(3) limit is found to provide a good description of data.

NetView technical research

NASA Technical Reports Server (NTRS)

1993-01-01

This is the Final Technical Report for the NetView Technical Research task. This report is prepared in accordance with Contract Data Requirements List (CDRL) item A002. NetView assistance was provided and details are presented under the following headings: NetView Management Systems (NMS) project tasks; WBAFB IBM 3090; WPAFB AMDAHL; WPAFB IBM 3084; Hill AFB; McClellan AFB AMDAHL; McClellan AFB IBM 3090; and Warner-Robins AFB.

Trajectory Reconstruction Program Milestone 2/3 Report. Volume 1. Description and Overview

DTIC Science & Technology

1974-12-16

Simulation Data Generation Missile Trajectory Error Analysis Modularized Program Guidance and Targeting Multiple Vehicle Simulation IBM 360/370 Numerical...consists of vehicle simulation subprograms designed and written in FORTRAN for CDC 6600/7600, IBM 360/370, and UNIVAC 1108/1110 series computers. The o-erall...vehicle simulation subprograms designed and written in FORTRAN fcr CDC 6600/7600, IBM 360/370, and UNIVAC l08/1110 series computers. The overall

Applications of Multiconductor Transmission Line Theory to the Prediction of Cable Coupling. Volume 7. Digital Computer Programs for the Analysis of Multiconductor Transmission Lines

DTIC Science & Technology

1977-07-01

on an IBM 370/165 computer at The University of Kentucky using the Fortran IV, G level compiler and should be easily implemented on other computers...order as the columns of T. 3.5.3 Subroutines NROOT and EIGEN Subroutines NROOT and EIGEN are a set of subroutines from the IBM Scientific Subroutine...November 1975). [10] System/360 Scientific Subroutine Package, Version III, Fifth Edition (August 1970), IBM Corporation, Technical Publications

Transforming the Force: A Comparative Analysis of the Department of Defense’s (DOD’s) Enterprise Resource Planning (ERP) Systems

DTIC Science & Technology

2007-09-01

the smaller ERP companies that produce specialized ERPs for particular industries. Five former IBM employees founded SAP and created the first ERP...Computer Sciences Corporations (CSC), Price Waterhouse Coopers, EDS, and IBM [2]. Selecting the right integrators is critical because they are the link... IBM was chosen as the integrator for the NEMAIS pilot. 5. Pilot Results and Road Ahead Between late 1998 and early 2002, the four Navy pilots took

SIAM Data Mining Brings It’ to Annual Meeting

DTIC Science & Technology

2017-02-24

address space) languages. Jose Moreira and Manoj Kumar from IBM presented the Graph Programming Interface (GPI) as well as a proposal for a common...Samsi (MIT), Dr. Manoj Kumar (IBM Research), Dr. Michel Kinsy (Boston University), and Dr. Shashank Yellapantula (GE Global Research). Dr. Gadepally...and Dr. Samsi discussed advances in data management technologies [22–25], and Dr. Kumar presented a brief overview of a graph-based API IBM is

Diversity as strategy.

PubMed

Thomas, David A

2004-09-01

IBM's turnaround in the last decade is an impressive and well-documented business story. But behind that success is a less told people story, which explains how the corporation dramatically altered its already diverse composition and created millions of dollars in new business. By the time Lou Gerstner took the helm in 1993, IBM had a long history of progressive management when it came to civil rights and equal-opportunity employment. But Gerstner felt IBM wasn't taking full advantage of a diverse market for talent, nor was it maximizing the potential of its diverse customer and employee base. So in 1995, he launched a diversity task force initiative to uncover and understand differences among people within the organization and find ways to appeal to an even broader set of employees and customers. Gerstner established a task force for each of eight constituencies: Asians; blacks; the gay, lesbian, bisexual, transgendered community; Hispanics; white men; Native Americans; people with disabilities; and women. He asked the task forces to research four questions: What does your constituency need to feel welcome and valued at IBM? What can the corporation do, in partnership with your group, to maximize your constituency's productivity? What can the corporation do to influence your constituency's buying decisions so that IBM is seen as a preferred solution provider? And with which external organizations should IBM form relationships to better understand the needs of your constituency? The answers to these questions became the basis for IBM's diversity strategy. Thomas stresses that four factors are key to implementing any major change initiative: strong support from company leaders, an employee base that is fully engaged with the initiative, management practices that are integrated and aligned with the effort, and a strong and well-articulated business case for action. All four elements have helped IBM make diversity a key corporate strategy tied to real growth.

Evaluation of the learning experiences afforded through multipractice learning in primary care: a project in the development of a multiprofessional learning organisation.

PubMed

Layzell, Sarah

2012-11-01

This mixed methods study used questionnaires and focus groups to evaluate a multiprofessional learning environment in which undergraduate pharmacy students were attached to general practices to learn alongside general practice specialist trainees (GPSTRs). All 27 of the first cohort of third-year undergraduate pharmacists elected to take part in the study. Mean Interdisciplinary Education Perception Scale (IEPS) scores showed little change between pre- and post-attachment questionnaires in the four domains: competency and autonomy; perceived need for cooperation; perception of actual cooperation and understanding of others' values. Individual paired tests showed an increase in understanding the values of others, which did not achieve statistical significance. The questionnaires further identified issues of trainee pharmacists' perceived low status, and feeling undervalued. Focus groups increased understanding of the perceptions and identified what the trainees saw as the unique learning experiences of their attachements: opportunities to practice their professional roles; to explore professional boundaries; and to achieve a better understanding of the organisation of primary care. However, full participation in interprofessional learning was limited by the interactions of powerplay between doctors and other team members and the perceived differences in professional standing.

Redox factor-1 in muscle biopsies of patients with inclusion-body myositis.

PubMed

Broccolini, A; Engel, W K; Alvarez, R B; Askanas, V

2000-06-16

To determine whether redox factor-1 (Ref-1) participates in the pathogenesis of inclusion-body myositis (IBM), we immunolocalized Ref-1 in muscle biopsies of IBM patients by light- and electron-microscopy. Approximately 70-80% of the IBM vacuolated muscle fibers had focal inclusions strongly immunoreactive for Ref-1. By immunoelectronmicroscopy, Ref-1 was localized to paired-helical filaments, 6-10 nm amyloid-like fibrils and amorphous material. Virtually all regenerating and necrotic muscle fibers in various muscle biopsies had diffusely strong Ref-1 immunoreactivity. At all neuromuscular junctions, postsynaptically there was strong Ref-1 immunoreactivity. Our study suggests that Ref-1 plays a role in IBM pathogenesis, and in other pathologic and normal processes of human muscle.

Structural Characterization of Cross-Linked Hemoglobins Developed as Potential Transfusion Substitutes

DTIC Science & Technology

1990-05-30

phase HPLC using an IBM Instruments Inc. model LC 9533 ternary liquid chromatograph attached to a model F9522 fixed UV module and a model F9523...acid analyses are done by separation and quantitation of phenylthiocarbamyl amino acid derivatives using a second IBM model LC 9533 ternary liquid...computer which controls the HPLC and an IBM Instruments Inc. model LC 9505 automatic sampler. The hemoglobin present in the effluent from large

Computer Architecture for Energy Efficient SFQ

DTIC Science & Technology

2014-08-27

IBM Corporation (T.J. Watson Research Laboratory) 1101 Kitchawan Road Yorktown Heights, NY 10598 -0000 2 ABSTRACT Number of Papers published in peer...accomplished during this ARO-sponsored project at IBM Research to identify and model an energy efficient SFQ-based computer architecture. The... IBM Windsor Blue (WB), illustrated schematically in Figure 2. The basic building block of WB is a "tile" comprised of a 64-bit arithmetic logic unit

DDN (Defense Data Network) Protocol Implementations and Vendors Guide

DTIC Science & Technology

1989-02-01

Announcement 286-259 6/16/86 MACHINE-TYPE/CPU: IBM RT/PC O/S: AIX DISTRIBUTOR: 1. IBM Marketing 2. IBM Authorized VAR’s 3. Authorized Personal Computer...Vendors Guide 12. PERSONAL AUTHOR(S) Dorio, Nan; Johnson, Marlyn; Lederman. Sol; Redfield, Elizabeth; Ward, Carol 13a. TYPE OF REPORT 13b. TIME COVERED 114...documentation, contact person , and distributor. The fourth section describes analysis tools. It includes information about network analysis products

Compositional Variations of Paleogene and Neogene Tephra From the Northern Izu-Bonin-Mariana Arc

NASA Astrophysics Data System (ADS)

Tepley, F. J., III; Barth, A. P.; Brandl, P. A.; Hickey-Vargas, R.; Jiang, F.; Kanayama, K.; Kusano, Y.; Li, H.; Marsaglia, K. M.; McCarthy, A.; Meffre, S.; Savov, I. P.; Yogodzinski, G. M.

2014-12-01

A primary objective of IODP Expedition 351 was to evaluate arc initiation processes of the Izu-Bonin-Mariana (IBM) volcanic arc and its compositional evolution through time. To this end, a single thick section of sediment overlying oceanic crust was cored in the Amami Sankaku Basin where a complete sediment record of arc inception and evolution is preserved. This sediment record includes ash and pyroclasts, deposited in fore-arc, arc, and back-arc settings, likely associated with both the ~49-25 Ma emergent IBM volcanic arc and the evolving Ryukyu-Kyushu volcanic arc. Our goal was to assess the major element evolution of the nascent and evolving IBM system using the temporally constrained record of the early and developing system. In all, more than 100 ash and tuff layers, and pyroclastic fragments were selected from temporally resolved portions of the core, and from representative fractions of the overall core ("core catcher"). The samples were prepared to determine major and minor element compositions via electron microprobe analyses. This ash and pyroclast record will allow us to 1) resolve the Paleogene evolutionary history of the northern IBM arc in greater detail; 2) determine compositional variations of this portion of the IBM arc through time; 3) compare the acquired data to an extensive whole rock and tephra dataset from other segments of the IBM arc; 4) test hypotheses of northern IBM arc evolution and the involvement of different source reservoirs; and 5) mark important stratigraphic markers associated with the Neogene volcanic history of the adjacent evolving Ryukyu-Kyushu arc.

Metrics of Software Quality.

DTIC Science & Technology

1980-11-01

Systems: A Raytheon Project History", RADC-TR-77-188, Final Technical Report, June 1977. 4. IBM Federal Systems Division, "Statistical Prediction of...147, June 1979. 4. W. D. Brooks, R. W. Motley, "Analysis of Discrete Software Reliability Models", IBM Corp., RADC-TR-80-84, RADC, New York, April 1980...J. C. King of IBM (Reference 9) and Lori A. Clark (Reference 10) of the University of Massachusetts. Programs, so exercised must be augmented so they

A Dimensionality Reduction Technique for Enhancing Information Context.

DTIC Science & Technology

1980-06-01

table, memory requirements for the difference arrays are based on the FORTRAN G programming languaee as implementated on an IBM 360/67. Single...the greatest amount of insight. All studies were performed on an IBM 360/67. Transformation 53 numerical results were produced as well as two...the origin to (19,19,19,19,19,19,19,19,19,l9). Two classes were generated in each case. The samples were synthetically derived using the IBM 360/57 and

SEI Software Engineering Education Directory.

DTIC Science & Technology

1987-02-01

Software Design and Development Gilbert. Philip Systems: CDC Cyber 170/750 CDC Cyber 170760 DEC POP 11/44 PRIME AT&T 3B5 IBM PC IBM XT IBM RT...Macintosh VAx 8300 Software System Development and Laboratory CS 480/480L U P X T Textbooks: Software Design and Development Gilbert, Philip Systems: CDC...Acting Chair (618) 692-2386 Courses: Software Design and Development CS 424 U P E Y Textbooks: Software Design and Development, Gilbert, Philip Topics

Inclusion Body Myositis

PubMed Central

Barohn, Richard J.

2014-01-01

The idiopathic inflammatory myopathies (IIM) are a heterogenous group of rare disorders that share many similarities. In addition to sporadic inclusion body myositis (IBM), these include dematomyositis (DM), polymyositis (PM), and autoimmune necrotizing myopathy (NM). For discussion of later three disorders, the reader is referred to the IIM review in this issue. IBM is the most common IIM after age 50. It typically presents with chronic insidious proximal leg and/or distal arm asymmetric muscle weakness leading to recurrent falls and loss of dexterity. Creatine kinase (CK) is up to 15 times elevated in IBM and needle electromyograhy (EMG) mostly shows a chronic irritative myopathy. Muscle histopathology demonstrates endomysial inflammatory exudates surrounding and invading non-necrotic muscle fibers often times accompanied by rimmed vacuoles and protein deposits. Despite inflammatory muscle pathology suggesting similarity with PM, it likely that IBM is has a prominent degenerative component as supported by refractoriness to immunosuppressive therapy. We review the evolution of our knowledge in IBM with emphasis on recent developments in the field and discuss ongoing clinical trials. PMID:25037082

Hot Chips and Hot Interconnects for High End Computing Systems

NASA Technical Reports Server (NTRS)

Saini, Subhash

2005-01-01

I will discuss several processors: 1. The Cray proprietary processor used in the Cray X1; 2. The IBM Power 3 and Power 4 used in an IBM SP 3 and IBM SP 4 systems; 3. The Intel Itanium and Xeon, used in the SGI Altix systems and clusters respectively; 4. IBM System-on-a-Chip used in IBM BlueGene/L; 5. HP Alpha EV68 processor used in DOE ASCI Q cluster; 6. SPARC64 V processor, which is used in the Fujitsu PRIMEPOWER HPC2500; 7. An NEC proprietary processor, which is used in NEC SX-6/7; 8. Power 4+ processor, which is used in Hitachi SR11000; 9. NEC proprietary processor, which is used in Earth Simulator. The IBM POWER5 and Red Storm Computing Systems will also be discussed. The architectures of these processors will first be presented, followed by interconnection networks and a description of high-end computer systems based on these processors and networks. The performance of various hardware/programming model combinations will then be compared, based on latest NAS Parallel Benchmark results (MPI, OpenMP/HPF and hybrid (MPI + OpenMP). The tutorial will conclude with a discussion of general trends in the field of high performance computing, (quantum computing, DNA computing, cellular engineering, and neural networks).

Clinicopathologic features of myositis patients with CD8-MHC-1 complex pathology.

PubMed

Ikenaga, Chiseko; Kubota, Akatsuki; Kadoya, Masato; Taira, Kenichiro; Uchio, Naohiro; Hida, Ayumi; Maeda, Meiko Hashimoto; Nagashima, Yu; Ishiura, Hiroyuki; Kaida, Kenichi; Goto, Jun; Tsuji, Shoji; Shimizu, Jun

2017-09-05

To determine the clinical features of myositis patients with the histopathologic finding of CD8-positive T cells invading non-necrotic muscle fibers expressing major histocompatibility complex class 1 (CD8-MHC-1 complex), which is shared by polymyositis (PM) and inclusion body myositis (IBM), in relation to the p62 immunostaining pattern of muscle fibers. All 93 myositis patients with CD8-MHC-1 complex who were referred to our hospital from 1993 to 2015 were classified on the basis of the European Neuromuscular Center (ENMC) diagnostic criteria for IBM (Rose, 2013) or PM (Hoogendijk, 2004) and analyzed. The 93 patients included were 17 patients with PM, 70 patients with IBM, and 6 patients who neither met the criteria for PM nor IBM in terms of muscle weakness distribution (unclassifiable group). For these PM, IBM, and unclassifiable patients, their mean ages at diagnosis were 63, 70, and 64 years; autoimmune disease was present in 7 (41%), 13 (19%), and 4 (67%); hepatitis C virus infection was detected in 0%, 13 (20%), and 2 (33%); and p62 was immunopositive in 0%, 66 (94%), and 2 (33%), respectively. Of the treated patients, 11 of 16 PM patients and 4 of 6 p62-immunonegative patients in the unclassifiable group showed responses to immunotherapy, whereas all 44 patients with IBM and 2 p62-immunopositive patients in the unclassifiable group were unresponsive to immunotherapy. CD8-MHC-1 complex is present in patients with PM, IBM, or unclassifiable group. The data may serve as an argument for a trial of immunosuppressive treatment in p62-immunonegative patients with unclassifiable myositis. © 2017 American Academy of Neurology.

List of Research Publications 1940-1980

DTIC Science & Technology

1981-10-01

comparison of the amount of tolerance for misplaced answers found in the GPO and the IBM machine-scored answer sheets. January 1942. (X6304) 1-18 A& .1...machine scoring of answer sheets. March 1942. The effect of the use of No. I pencils on the accuracy of scoring IBM answer sheets by machine. July 1942...X6427) 482 Hobbies - IBM code. 483 Relationship of Classification Test, R-I and WAC Classi- 4023 fication Test-2 for a recruiting station population

IODP Expedition 351 Izu-Bonin-Mariana Arc Origins: Preliminary Results

NASA Astrophysics Data System (ADS)

Ishizuka, O.; Arculus, R. J.; Bogus, K.

2014-12-01

Understanding how subduction zones initiate and continental crust forms in intraoceanic arcs requires knowledge of the inception and evolution of a representative intraoceanic arc, such as the Izu-Bonin-Mariana (IBM) Arc system. This can be obtained by exploring regions adjacent to an arc, where unequivocal pre-arc crust overlain by undisturbed arc-derived materials exists. IODP Exp. 351 (June-July 2014) specifically targeted evidence for the earliest evolution of the IBM system following inception. Site U1438 (4711 m water depth) is located in the Amami Sankaku Basin (ASB), west of the Kyushu-Palau Ridge (KPR), a paleo-IBM arc. Primary objectives of Exp. 351 were: 1) determine the nature of the crust and mantle pre-existing the IBM arc; 2) identify and model the process of subduction initiation and initial arc crust formation; 3) determine the compositional evolution of the IBM arc during the Paleogene; 4) establish geophysical properties of the ASB. Seismic reflection profiles indicate a ~1.3 km thick sediment layer overlying ~5.5 km thick igneous crust, presumed to be oceanic. This igneous crust seemed likely to be the basement of the IBM arc. Four holes were cored at Site U1438 spanning the entire sediment section and into basement. The cored interval comprises 5 units: uppermost Unit I is hemipelagic sediment with intercalated ash layers, presumably recording explosive volcanism mainly from the Ryukyu and Kyushu arcs; Units II and III host a series of volcaniclastic gravity-flow deposits, likely recording the magmatic history of the IBM Arc from arc initiation until 25 Ma; Siliceous pelagic sediment (Unit IV) underlies these deposits with minimal coarse-grained sediment input and may pre-date arc initiation. Sediment-basement contact occurs at 1461 mbsf. A basaltic lava flow section dominantly composed of plagioclase and clinopyroxene with rare chilled margins continues to the bottom of the Site (1611 mbsf). The expedition successfully recovered pre-IBM Arc

Design and performance analysis of solid-propellant rocket motors using a simplified computer program

NASA Technical Reports Server (NTRS)

Sforzini, R. H.

1972-01-01

An analysis and a computer program are presented which represent a compromise between the more sophisticated programs using precise burning geometric relations and the textbook type of solutions. The program requires approximately 900 computer cards including a set of 20 input data cards required for a typical problem. The computer operating time for a single configuration is approximately 1 minute and 30 seconds on the IBM 360 computer. About l minute and l5 seconds of the time is compilation time so that additional configurations input at the same time require approximately 15 seconds each. The program uses approximately 11,000 words on the IBM 360. The program is written in FORTRAN 4 and is readily adaptable for use on a number of different computers: IBM 7044, IBM 7094, and Univac 1108.

Sporadic inclusion-body myositis: conformational multifactorial ageing-related degenerative muscle disease associated with proteasomal and lysosomal inhibition, endoplasmic reticulum stress, and accumulation of amyloid-β42 oligomers and phosphorylated tau.

PubMed

Askanas, Valerie; Engel, W King

2011-04-01

The pathogenesis of sporadic inclusion-body myositis (s-IBM), the most common muscle disease of older persons, is complex and multifactorial. Both the muscle fiber degeneration and the mononuclear-cell inflammation are components of the s-IBM pathology, but how each relates to the pathogenesis remains unsettled. We consider that the intramuscle fiber degenerative component plays the primary and the major pathogenic role leading to muscle fiber destruction and clinical weakness. In this article we review the newest research advances that provide a better understanding of the s-IBM pathogenesis. Cellular abnormalities occurring in s-IBM muscle fibers are discussed, including: several proteins that are accumulated in the form of aggregates within muscle fibers, including amyloid-β42 and its oligomers, and phosphorylated tau in the form of paired helical filaments, and we consider their putative detrimental influence; cellular mechanisms leading to protein misfolding and aggregation, including evidence of their inadequate disposal; pathogenic importance of endoplasmic reticulum stress and the unfolded protein response demonstrated in s-IBM muscle fibers; and decreased deacetylase activity of SIRT1. All these factors are combined with, and perhaps provoked by, an ageing intracellular milieu. Also discussed are the intriguing phenotypic similarities between s-IBM muscle fibers and the brains of Alzheimer and Parkinson's disease patients, the two most common neurodegenerative diseases associated with ageing. Muscle biopsy diagnostic criteria are also described and illustrated. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

Mitochondrial pathology in inclusion body myositis.

PubMed

Lindgren, Ulrika; Roos, Sara; Hedberg Oldfors, Carola; Moslemi, Ali-Reza; Lindberg, Christopher; Oldfors, Anders

2015-04-01

Inclusion body myositis (IBM) is usually associated with a large number of cytochrome c oxidase (COX)-deficient muscle fibers and acquired mitochondrial DNA (mtDNA) deletions. We studied the number of COX-deficient fibers and the amount of mtDNA deletions, and if variants in nuclear genes involved in mtDNA maintenance may contribute to the occurrence of mtDNA deletions in IBM muscle. Twenty-six IBM patients were included. COX-deficient fibers were assayed by morphometry and mtDNA deletions by qPCR. POLG was analyzed in all patients by Sanger sequencing and C10orf2 (Twinkle), DNA2, MGME1, OPA1, POLG2, RRM2B, SLC25A4 and TYMP in six patients by next generation sequencing. Patients with many COX-deficient muscle fibers had a significantly higher proportion of mtDNA deletions than patients with few COX-deficient fibers. We found previously unreported variants in POLG and C10orf2 and IBM patients had a significantly higher frequency of an RRM2B variant than controls. POLG variants appeared more common in IBM patients with many COX-deficient fibers, but the difference was not statistically significant. We conclude that COX-deficient fibers in inclusion body myositis are associated with multiple mtDNA deletions. In IBM patients we found novel and also previously reported variants in genes of importance for mtDNA maintenance that warrants further studies. Copyright © 2014 Elsevier B.V. All rights reserved.

CT image biomarkers to improve patient-specific prediction of radiation-induced xerostomia and sticky saliva.

PubMed

van Dijk, Lisanne V; Brouwer, Charlotte L; van der Schaaf, Arjen; Burgerhof, Johannes G M; Beukinga, Roelof J; Langendijk, Johannes A; Sijtsema, Nanna M; Steenbakkers, Roel J H M

2017-02-01

Current models for the prediction of late patient-rated moderate-to-severe xerostomia (XER 12m ) and sticky saliva (STIC 12m ) after radiotherapy are based on dose-volume parameters and baseline xerostomia (XER base ) or sticky saliva (STIC base ) scores. The purpose is to improve prediction of XER 12m and STIC 12m with patient-specific characteristics, based on CT image biomarkers (IBMs). Planning CT-scans and patient-rated outcome measures were prospectively collected for 249 head and neck cancer patients treated with definitive radiotherapy with or without systemic treatment. The potential IBMs represent geometric, CT intensity and textural characteristics of the parotid and submandibular glands. Lasso regularisation was used to create multivariable logistic regression models, which were internally validated by bootstrapping. The prediction of XER 12m could be improved significantly by adding the IBM "Short Run Emphasis" (SRE), which quantifies heterogeneity of parotid tissue, to a model with mean contra-lateral parotid gland dose and XER base . For STIC 12m , the IBM maximum CT intensity of the submandibular gland was selected in addition to STIC base and mean dose to submandibular glands. Prediction of XER 12m and STIC 12m was improved by including IBMs representing heterogeneity and density of the salivary glands, respectively. These IBMs could guide additional research to the patient-specific response of healthy tissue to radiation dose. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

Physical Properties and Seismic Structure of Izu-Bonin-Mariana Fore Arc crust: Results From IODP Expedition 352 and Comparison with Oceanic Crust

NASA Astrophysics Data System (ADS)

Christeson, G. L.; Morgan, S.; Kodaira, S.; Yamashita, M.

2015-12-01

Most of the well-preserved ophiolite complexes are believed to form in supra-subduction zone settings. One of the goals of IODP Expedition 352 was to test the supra-subduction zone ophiolite model by drilling forearc crust at the northern Izu-Bonin-Mariana (IBM) system. IBM forearc drilling successfully cored 1.22 km of volcanic lavas and underlying dikes at four sites. A surprising observation is that basement compressional velocities measured from downhole logging average ~3.0 km/s, compared to values of 5 km/s at similar basement depths at oceanic crust sites 504B and 1256D. Typically there is an inverse relationship in extrusive lavas between velocity and porosity, but downhole logging shows similar porosities for the IBM and oceanic crust sites, despite the large difference in measured compressional velocities. These observations can be explained by a difference in crack morphologies between IBM forearc and oceanic crust, with a smaller fractional area of asperity contact across cracks at EXP 352 sites than at sites 504B and 1256D. Seismic profiles at the IBM forearc image many faults, which may be related to the crack population.

Careers and people

NASA Astrophysics Data System (ADS)

2009-09-01

IBM scientist wins magnetism prizes Stuart Parkin, an applied physicist at IBM's Almaden Research Center, has won the European Geophysical Society's Néel Medal and the Magnetism Award from the International Union of Pure and Applied Physics (IUPAP) for his fundamental contributions to nanodevices used in information storage. Parkin's research on giant magnetoresistance in the late 1980s led IBM to develop computer hard drives that packed 1000 times more data onto a disk; his recent work focuses on increasing the storage capacity of solid-state electronic devices.

TAP II Beamforming System Software Final Report

DTIC Science & Technology

1977-05-01

3.0 IBM TAPE FORMATS......... ............. -1 • 3 . 2 C om p le x C o e f f ic i e n t 8 . *.. . o t... . . . . . . .. . . . . . . . 3 - 5 :i • 3.3...parameters. Output to the line - printer and CRT are inhibited, but the IBM tapes are written. d Li UNCLASSIFIED CONFIDENTIALI A2 2.5 (C) EDITING (U...t• •• ", .. . .. . ..•" ;"• :, • .••.•-. ~ ., ~ ,., ,~.’ " ’t••. •± CONFIDENTIAL LI 3.0 (C) IBM TAPE FORMATS (U) .B 3.1 (U) GENERAL

Software Reviews.

ERIC Educational Resources Information Center

Bitter, Gary G., Ed.

1989-01-01

Describes three software packages: (1) "MacMendeleev"--database/graphic display for chemistry, grades 10-12, Macintosh; (2) "Geometry One: Foundations"--geometry tutorial, grades 7-12, IBM; (3) "Mathematics Exploration Toolkit"--algebra and calculus tutorial, grades 8-12, IBM. (MVL)

Injuries and Illnesses of Vietnam War POWs Revisited: IV. Air Force Risk Factors

DTIC Science & Technology

2017-03-22

predominantly aviators imprisoned in North Vietnam. Statistical analyses were performed using SPSS version 19. Pearson correlations were obtained...Repatriated Prisoner of War Initial Medical Evaluation Forms. Department of Defense. Washington, D.C. 5. IBM Corporation (2010). IBM SPSS Statistics for

78 FR 42804 - SST Truck Company, LLC, a Navistar, Inc. Company Including On-Site Leased Workers From Employee...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-17

... Contract Services, Encore, International Business Machines (IBM), Akzo Nobel, US Security, ASF Logistics... Services, Encore, International Business Machines (IBM), Akzo Nobel, US Security, ASF Logistics, LLC... class 4-8 trucks. The company reports that workers leased from Encore, International Business Machines...

The Computer Bulletin Board.

ERIC Educational Resources Information Center

Batt, Russell H., Ed.

1989-01-01

Describes two chemistry computer programs: (1) "Eureka: A Chemistry Problem Solver" (problem files may be written by the instructor, MS-DOS 2.0, IBM with 384K); and (2) "PC-File+" (database management, IBM with 416K and two floppy drives). (MVL)

An individual-based model of zebrafish population dynamics accounting for energy dynamics.

PubMed

Beaudouin, Rémy; Goussen, Benoit; Piccini, Benjamin; Augustine, Starrlight; Devillers, James; Brion, François; Péry, Alexandre R R

2015-01-01

Developing population dynamics models for zebrafish is crucial in order to extrapolate from toxicity data measured at the organism level to biological levels relevant to support and enhance ecological risk assessment. To achieve this, a dynamic energy budget for individual zebrafish (DEB model) was coupled to an individual based model of zebrafish population dynamics (IBM model). Next, we fitted the DEB model to new experimental data on zebrafish growth and reproduction thus improving existing models. We further analysed the DEB-model and DEB-IBM using a sensitivity analysis. Finally, the predictions of the DEB-IBM were compared to existing observations on natural zebrafish populations and the predicted population dynamics are realistic. While our zebrafish DEB-IBM model can still be improved by acquiring new experimental data on the most uncertain processes (e.g. survival or feeding), it can already serve to predict the impact of compounds at the population level.

Hereditary inclusion-body myopathy: clues on pathogenesis and possible therapy.

PubMed

Broccolini, Aldobrando; Gidaro, Teresa; Morosetti, Roberta; Mirabella, Massimiliano

2009-09-01

Hereditary inclusion-body myopathy (h-IBM), or distal myopathy with rimmed vacuoles (DMRV), is an autosomal recessive disorder with onset in early adult life and a progressive course leading to severe disability. h-IBM/DMRV is due to mutations of a gene (GNE) that codes for a rate-limiting enzyme in the sialic acid biosynthetic pathway. Despite the identification of the causative gene defect, it has not been unambiguously clarified how GNE gene mutations impair muscle metabolism. Although numerous studies have indicated a key role of hyposialylation of glycoproteins in h-IBM/DMRV pathogenesis, others have demonstrated new and unpredicted functions of the GNE gene, outside the sialic acid biosynthetic pathway, that may also be relevant. This review illustrates the clinical and pathologic characteristics of h-IBM/DMRV and the main clues available to date concerning the possible pathogenic mechanisms and therapeutic perspectives of this disorder.

The ER-bound RING finger protein 5 (RNF5/RMA1) causes degenerative myopathy in transgenic mice and is deregulated in inclusion body myositis.

PubMed

Delaunay, Agnès; Bromberg, Kenneth D; Hayashi, Yukiko; Mirabella, Massimiliano; Burch, Denise; Kirkwood, Brian; Serra, Carlo; Malicdan, May C; Mizisin, Andrew P; Morosetti, Roberta; Broccolini, Aldobrando; Guo, Ling T; Jones, Stephen N; Lira, Sergio A; Puri, Pier Lorenzo; Shelton, G Diane; Ronai, Ze'ev

2008-02-13

Growing evidence supports the importance of ubiquitin ligases in the pathogenesis of muscular disorders, although underlying mechanisms remain largely elusive. Here we show that the expression of RNF5 (aka RMA1), an ER-anchored RING finger E3 ligase implicated in muscle organization and in recognition and processing of malfolded proteins, is elevated and mislocalized to cytoplasmic aggregates in biopsies from patients suffering from sporadic-Inclusion Body Myositis (sIBM). Consistent with these findings, an animal model for hereditary IBM (hIBM), but not their control littermates, revealed deregulated expression of RNF5. Further studies for the role of RNF5 in the pathogenesis of s-IBM and more generally in muscle physiology were performed using RNF5 transgenic and KO animals. Transgenic mice carrying inducible expression of RNF5, under control of beta-actin or muscle specific promoter, exhibit an early onset of muscle wasting, muscle degeneration and extensive fiber regeneration. Prolonged expression of RNF5 in the muscle also results in the formation of fibers containing congophilic material, blue-rimmed vacuoles and inclusion bodies. These phenotypes were associated with altered expression and activity of ER chaperones, characteristic of myodegenerative diseases such as s-IBM. Conversely, muscle regeneration and induction of ER stress markers were delayed in RNF5 KO mice subjected to cardiotoxin treatment. While supporting a role for RNF5 Tg mice as model for s-IBM, our study also establishes the importance of RNF5 in muscle physiology and its deregulation in ER stress associated muscular disorders.

The ER-Bound RING Finger Protein 5 (RNF5/RMA1) Causes Degenerative Myopathy in Transgenic Mice and Is Deregulated in Inclusion Body Myositis

PubMed Central

Delaunay, Agnès; Bromberg, Kenneth D.; Hayashi, Yukiko; Mirabella, Massimiliano; Burch, Denise; Kirkwood, Brian; Serra, Carlo; Malicdan, May C.; Mizisin, Andrew P.; Morosetti, Roberta; Broccolini, Aldobrando; Guo, Ling T.; Jones, Stephen N.; Lira, Sergio A.; Puri, Pier Lorenzo; Shelton, G. Diane; Ronai, Ze'ev

2008-01-01

Growing evidence supports the importance of ubiquitin ligases in the pathogenesis of muscular disorders, although underlying mechanisms remain largely elusive. Here we show that the expression of RNF5 (aka RMA1), an ER-anchored RING finger E3 ligase implicated in muscle organization and in recognition and processing of malfolded proteins, is elevated and mislocalized to cytoplasmic aggregates in biopsies from patients suffering from sporadic-Inclusion Body Myositis (sIBM). Consistent with these findings, an animal model for hereditary IBM (hIBM), but not their control littermates, revealed deregulated expression of RNF5. Further studies for the role of RNF5 in the pathogenesis of s-IBM and more generally in muscle physiology were performed using RNF5 transgenic and KO animals. Transgenic mice carrying inducible expression of RNF5, under control of β-actin or muscle specific promoter, exhibit an early onset of muscle wasting, muscle degeneration and extensive fiber regeneration. Prolonged expression of RNF5 in the muscle also results in the formation of fibers containing congophilic material, blue-rimmed vacuoles and inclusion bodies. These phenotypes were associated with altered expression and activity of ER chaperones, characteristic of myodegenerative diseases such as s-IBM. Conversely, muscle regeneration and induction of ER stress markers were delayed in RNF5 KO mice subjected to cardiotoxin treatment. While supporting a role for RNF5 Tg mice as model for s-IBM, our study also establishes the importance of RNF5 in muscle physiology and its deregulation in ER stress associated muscular disorders. PMID:18270596

Mortality and Causes of Death in Patients with Sporadic Inclusion Body Myositis: Survey Study Based on the Clinical Experience of Specialists in Australia, Europe and the USA.

PubMed

Price, Mark A; Barghout, Victoria; Benveniste, Olivier; Christopher-Stine, Lisa; Corbett, Alastair; de Visser, Marianne; Hilton-Jones, David; Kissel, John T; Lloyd, Thomas E; Lundberg, Ingrid E; Mastaglia, Francis; Mozaffar, Tahseen; Needham, Merrilee; Schmidt, Jens; Sivakumar, Kumaraswamy; DeMuro, Carla; Tseng, Brian S

2016-03-03

There is a paucity of data on mortality and causes of death (CoDs) in patients with sporadic inclusion body myositis (sIBM), a rare, progressive, degenerative, inflammatory myopathy that typically affects those aged over 50 years. Based on patient records and expertise of clinical specialists, this study used questionnaires to evaluate physicians' views on clinical characteristics of sIBM that may impact on premature mortality and CoDs in these patients. Thirteen physicians from seven countries completed two questionnaires online between December 20, 2012 and January 15, 2013. Responses to the first questionnaire were collated and presented in the second questionnaire to seek elaboration and identify consensus. All 13 physicians completed both questionnaires, providing responses based on 585 living and 149 deceased patients under their care. Patients were reported to have experienced dysphagia (60.2%) and injurious falls (44.3%) during their disease. Over half of physicians reported that a subset of their patients with sIBM had a shortened lifespan (8/13), and agreed that bulbar dysfunction/dysphagia/oropharyngeal involvement (12/13), early-onset disease (8/13), severe symptoms (8/13), and falls (7/13) impacted lifespan. Factors related to sIBM were reported as CoDs in 40% of deceased patients. Oropharyngeal muscle dysfunction was ranked as the leading feature of sIBM that could contribute to death. The risk of premature mortality was higher than the age-matched comparison population. In the absence of data from traditional sources, this study suggests that features of sIBM may contribute to premature mortality and may be used to inform future studies.

‘This town’s a different town today’:

PubMed Central

Hadfield, Phil; Lister, Stuart; Traynor, Peter

2010-01-01

This article considers recent policing and regulatory responses to the night-time economy in England and Wales. Drawing upon the findings of a broader two-year qualitative investigation of local and national developments in alcohol policy, it identifies a dramatic acceleration of statutory activity, with 12 new or revised powers, and several more in prospect, introduced by the Labour Government within its first decade in office. Interview data and documentary sources are used to explore the degree to which the introduction of such powers, often accompanied by forceful rhetoric and high profile police action, has translated into a sustained expansion of control. Many of the new powers are spatially directed, as well as being focused upon the actions of distinct individuals or businesses, yet the willingness and capacity to apply powers to offending individuals in comparison to businesses is often variable and asymmetrical. The practice of negotiating order in the night-time economy is riddled with tensions and ambiguities that reflect the ad hoc nature and rapid escalation of the regulatory architecture. Night-time urban security governance is understood as the outcome of subtle organizational and interpersonal power-plays. Social orders, normative schemas and apportionments of blame thus arise as a byproduct of patterned (structural) relations. PMID:20401315

Reviews.

ERIC Educational Resources Information Center

Journal of Chemical Education, 1988

1988-01-01

Reviews three softwre packages: "Molecular Graphics on the Apple Microcomputer, Enhanced Version 2.0"; "Molecular Graphics on the IBM PC Microcomputer"; and "Molecular Animator, IBM PC Version." Packages are rated based on ease of use, subject matter content, pedagogic value, and student reaction. (CW)

Plutonic rocks in the Mineoka-Setogawa ophiolitic mélange, central Japan: Fragments of middle to lower crust of the Izu-Bonin-Mariana Arc?

NASA Astrophysics Data System (ADS)

Ichiyama, Yuji; Ito, Hisatoshi; Hokanishi, Natsumi; Tamura, Akihiro; Arai, Shoji

2017-06-01

A Paleogene accretionary complex, the Mineoka-Setogawa Belt, is distributed around the Izu Collision Zone, central Japan. Plutonic rocks of gabbro, diorite and tonalite compositions are included as fragments and dykes in an ophiolitic mélange in this belt. Zircon U-Pb dating of the plutonic rocks indicates that they were formed at ca. 35 Ma simultaneously. These ages are consistent with Eocene-Oligocene tholeiite and calc-alkaline arc magmatism in the Izu-Bonin-Mariana (IBM) Arc and exclude several previous models for the origin of the Mineoka-Setogawa ophiolitic rocks. The geochemical characteristics of these plutonic rocks are similar to those of the Eocene-Oligocene IBM tholeiite and calc-alkaline volcanic rocks as well as to the accreted middle crust of the IBM Arc, the Tanzawa Plutonic Complex. Moreover, their lithology is consistent with those of the middle and lower crust of the IBM Arc estimated from the seismic velocity structure. These lines of evidence strongly indicate that the plutonic rocks in the Mineoka-Setogawa ophiolitic mélange are fragments of the middle to lower crust of the IBM Arc. Additionally, the presence of the Mineoka-Setogawa intermediate to felsic plutonic rocks supports the hypothesis that intermediate magma can form continental crust in intra-oceanic arcs.

Botulinum toxin alleviates dysphagia of patients with inclusion body myositis.

PubMed

Schrey, Aleksi; Airas, Laura; Jokela, Manu; Pulkkinen, Jaakko

2017-09-15

Oropharyngeal dysphagia is a disabling and undertreated symptom that often occurs in patients with sporadic inclusion body myositis (s-IBM). In this study, we examined the effect of botulinum neurotoxin A (BoNT-A) injections to the cricopharyngeus muscle (CPM) of patients with s-IBM and dysphagia. A single-center retrospective study involving 40 biopsy-proven s-IBM-patients treated in the District of Southwest Finland from 2000 to 2013. The incidence of dysphagia, rate of aspirations, rate of aspiration pneumonias and treatment results of dysphagia were analyzed. Patients treated for dysphagia were evaluated before and after surgery by video-fluoroscopy and/or using a questionnaire. Twenty-five of the 40 s-IBM patients (62.5%) experienced dysphagia. BoNT-A was injected a median of 2 times (range 1-7) in 12 patients with dysphagia. Before the injections 7 patients reported aspiration, none afterwards. The corresponding figures for aspiration pneumonia were 3 and 0. All of these patients had normal swallowing function 12months (median, range 2-60) after the last injection. BoNT-A injections to the CPM alleviate the dysphagia of s-IBM patients reversibly and appear to reduce the rate of aspiration effectively. Copyright © 2017 Elsevier B.V. All rights reserved.

Hyposialylation of neprilysin possibly affects its expression and enzymatic activity in hereditary inclusion-body myopathy muscle.

PubMed

Broccolini, Aldobrando; Gidaro, Teresa; De Cristofaro, Raimondo; Morosetti, Roberta; Gliubizzi, Carla; Ricci, Enzo; Tonali, Pietro A; Mirabella, Massimiliano

2008-05-01

Autosomal recessive hereditary inclusion-body myopathy (h-IBM) is caused by mutations of the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase gene, a rate-limiting enzyme in the sialic acid metabolic pathway. Previous studies have demonstrated an abnormal sialylation of glycoproteins in h-IBM. h-IBM muscle shows the abnormal accumulation of proteins including amyloid-beta (Abeta). Neprilysin (NEP), a metallopeptidase that cleaves Abeta, is characterized by the presence of several N-glycosylation sites, and changes in these sugar moieties affect its stability and enzymatic activity. In the present study, we found that NEP is hyposialylated and its expression and enzymatic activity reduced in all h-IBM muscles analyzed. In vitro, the experimental removal of sialic acid by Vibrio Cholerae neuraminidase in cultured myotubes resulted in reduced expression of NEP. This was most likely because of a post-translational modification consisting in an abnormal sialylation of the protein that leads to its reduced stability. Moreover, treatment with Vibrio Cholerae neuraminidase was associated with an increased immunoreactivity for Abeta mainly in the form of distinct cytoplasmic foci within myotubes. We hypothesize that, in h-IBM muscle, hyposialylated NEP has a role in hampering the cellular Abeta clearing system, thus contributing to its abnormal accumulation within vulnerable fibers and possibly promoting muscle degeneration.

INDIVIDUAL-BASED MODELS: POWERFUL OR POWER STRUGGLE?

PubMed

Willem, L; Stijven, S; Hens, N; Vladislavleva, E; Broeckhove, J; Beutels, P

2015-01-01

Individual-based models (IBMs) offer endless possibilities to explore various research questions but come with high model complexity and computational burden. Large-scale IBMs have become feasible but the novel hardware architectures require adapted software. The increased model complexity also requires systematic exploration to gain thorough system understanding. We elaborate on the development of IBMs for vaccine-preventable infectious diseases and model exploration with active learning. Investment in IBM simulator code can lead to significant runtime reductions. We found large performance differences due to data locality. Sorting the population once, reduced simulation time by a factor two. Storing person attributes separately instead of using person objects also seemed more efficient. Next, we improved model performance up to 70% by structuring potential contacts based on health status before processing disease transmission. The active learning approach we present is based on iterative surrogate modelling and model-guided experimentation. Symbolic regression is used for nonlinear response surface modelling with automatic feature selection. We illustrate our approach using an IBM for influenza vaccination. After optimizing the parameter spade, we observed an inverse relationship between vaccination coverage and the clinical attack rate reinforced by herd immunity. These insights can be used to focus and optimise research activities, and to reduce both dimensionality and decision uncertainty.

Proposed Missions and Organization of the U.S. Army Research, Development and Engineering Command

DTIC Science & Technology

2005-01-01

successfully employed in many industries and by many companies, including Pittsburgh Steel, IBM, Unilever , and Ford. Each of these organizations fine- tuned...employed by many companies, such as Pittsburgh Steel, IBM, Unilever , and Ford, which have fine-tuned the matrix to suit their particular goals and

Goddard Space Flight Center specification for Helical-Scan 8-millimeter (mm) magnetic digital data tape cartridge

NASA Technical Reports Server (NTRS)

Perry, Jimmy L.

1992-01-01

The same kind of standard and controls are established that are currently in use for the procurement of new analog, digital, and IBM/IBM compatible 3480 tape cartridges, and 1 in wide channel video magnetic tapes. The Magnetic Tape Certification Facility (MTCF) maintains a Qualified Products List (QPL) for the procurement of new magnetic media and uses the following specifications for the QPL and Acceptance Tests: (1) NASA TM-79724 is used for the QPL and Acceptance Testing of new analog magnetic tapes; (2) NASA TM-80599 is used for the QPL and Acceptance Testing of new digital magnetic tapes; (3) NASA TM-100702 is used for the QPL and Acceptance Testing of new IBM/IBM compatible 3840 magnetic tape cartridges; and (4) NASA TM-100712 is used for the QPL and Acceptance Testing of new 1 in wide channel video magnetic tapes. This document will be used for the QPL and Acceptance Testing of new Helical Scan 8 mm digital data tape cartridges.

An Individual-Based Model of Zebrafish Population Dynamics Accounting for Energy Dynamics

PubMed Central

Beaudouin, Rémy; Goussen, Benoit; Piccini, Benjamin; Augustine, Starrlight; Devillers, James; Brion, François; Péry, Alexandre R. R.

2015-01-01

Developing population dynamics models for zebrafish is crucial in order to extrapolate from toxicity data measured at the organism level to biological levels relevant to support and enhance ecological risk assessment. To achieve this, a dynamic energy budget for individual zebrafish (DEB model) was coupled to an individual based model of zebrafish population dynamics (IBM model). Next, we fitted the DEB model to new experimental data on zebrafish growth and reproduction thus improving existing models. We further analysed the DEB-model and DEB-IBM using a sensitivity analysis. Finally, the predictions of the DEB-IBM were compared to existing observations on natural zebrafish populations and the predicted population dynamics are realistic. While our zebrafish DEB-IBM model can still be improved by acquiring new experimental data on the most uncertain processes (e.g. survival or feeding), it can already serve to predict the impact of compounds at the population level. PMID:25938409

Inclusion Body Myositis

PubMed Central

Dimachkie, Mazen M.; Barohn, Richard J.

2012-01-01

The idiopathic inflammatory myopathies are a group of rare disorders that share many similarities. These include dermatomyositis (DM), polymyositis (PM), necrotizing myopathy (NM), and sporadic inclusion body myositis (IBM). Inclusion body myositis is the most common idiopathic inflammatory myopathy after age 50 and it presents with chronic proximal leg and distal arm asymmetric mucle weakness. Despite similarities with PM, it is likely that IBM is primarily a degenerative disorder rather than an inflammatory muscle disease. Inclusion body myositis is associated with a modest degree of creatine kinase (CK) elevation and an abnormal electromyogram demonstrating an irritative myopathy with some chronicity. The muscle histopathology demonstrates inflammatory exudates surrounding and invading nonnecrotic muscle fibers often times accompanied by rimmed vacuoles. In this chapter, we review sporadic IBM. We also examine past, essentially negative, clinical trials in IBM and review ongoing clinical trials. For further details on DM, PM, and NM, the reader is referred to the idiopathic inflammatory myopathies chapter. PMID:23117948

Making Predictions in a Changing World: The Benefits of Individual-Based Ecology

PubMed Central

Stillman, Richard A.; Railsback, Steven F.; Giske, Jarl; Berger, Uta; Grimm, Volker

2014-01-01

Ecologists urgently need a better ability to predict how environmental change affects biodiversity. We examine individual-based ecology (IBE), a research paradigm that promises better a predictive ability by using individual-based models (IBMs) to represent ecological dynamics as arising from how individuals interact with their environment and with each other. A key advantage of IBMs is that the basis for predictions—fitness maximization by individual organisms—is more general and reliable than the empirical relationships that other models depend on. Case studies illustrate the usefulness and predictive success of long-term IBE programs. The pioneering programs had three phases: conceptualization, implementation, and diversification. Continued validation of models runs throughout these phases. The breakthroughs that make IBE more productive include standards for describing and validating IBMs, improved and standardized theory for individual traits and behavior, software tools, and generalized instead of system-specific IBMs. We provide guidelines for pursuing IBE and a vision for future IBE research. PMID:26955076

Software Reviews. Programs Worth a Second Look.

ERIC Educational Resources Information Center

Schneider, Roxanne; Eiser, Leslie

1989-01-01

Reviewed are three computer software packages for use in middle/high school classrooms. Included are "MacWrite II," a word-processing program for MacIntosh computers; "Super Story Tree," a word-processing program for Apple and IBM computers; and "Math Blaster Mystery," for IBM, Apple, and Tandy computers. (CW)

Software Reviews: Programs Worth a Second Look.

ERIC Educational Resources Information Center

Olds, Henry F., Jr.; And Others

1988-01-01

Examines four software packages: (1) "Wordbench"--writing and word processing, grades 9-12 (IBM and Apple); (2) "Muppet Slate"--language arts, grades K-2 (Apple); (3) "Accu-Weather Forecaster"--weather analysis and forecasting, grades 3-12 (modem with IBM or Mac); and (4) "The Ripple That Changed American…

Technology for Persons with Disabilities. An Introduction.

ERIC Educational Resources Information Center

IBM, Atlanta, GA. National Support Center for Persons with Disabilities.

This paper contains an overview of technology, national support organizations, and IBM support available to persons with disabilities related to impairments affecting hearing, learning, mobility, speech or language, and vision. The information was obtained from the IBM National Support Center for Persons with Disabilities, which was created to…

Resource Guide for Persons with Speech or Language Impairments.

ERIC Educational Resources Information Center

IBM, Atlanta, GA. National Support Center for Persons with Disabilities.

The resource guide identifies products which assist speech or language impaired individuals in accessing IBM (International Business Machine) Personal Computers or the IBM Personal System/2 family of products. An introduction provides a general overview of ways computers can help persons with speech or language handicaps. The document then…

Using ZWDOS to Communicate in Chinese on PC.

ERIC Educational Resources Information Center

Xie, Tianwei

1995-01-01

Describes the availability, installation, and use of the ZhonWen Disk Operating System (ZWDOS) to display, print, and transmit Chinese characters on conventional International Business Machines (IBM) personal computers and IBM-compatible machines. Also discussed is the use of ZWDOS to compose electronic mail messages, read newsgroups, and access…

TAE+ 5.2 - TRANSPORTABLE APPLICATIONS ENVIRONMENT PLUS, VERSION 5.2 (IBM RS/6000 VERSION)

NASA Technical Reports Server (NTRS)

TAE SUPPORT OFFICE

1994-01-01

programs to display and control the user interfaces. Since the WPTs access the workbench-generated resource files during each execution, details such as color, font, location, and object type remain independent from the application code, allowing changes to the user interface without recompiling and relinking. In addition to WPTs, TAE Plus can control interaction of objects from the interpreted TAE Command Language. TCL provides a means for the more experienced developer to quickly prototype an application's use of TAE Plus interaction objects and add programming logic without the overhead of compiling or linking. TAE Plus requires MIT's X Window System and the Open Software Foundation's Motif. The HP 9000 Series 700/800 version of TAE 5.2 requires Version 11 Release 5 of the X Window System. All other machine versions of TAE 5.2 require Version 11, Release 4 of the X Window System. The Workbench and WPTs are written in C++ and the remaining code is written in C. TAE Plus is available by license for an unlimited time period. The licensed program product includes the TAE Plus source code and one set of supporting documentation. Additional documentation may be purchased separately at the price indicated below. The amount of disk space required to load the TAE Plus tar format tape is between 35Mb and 67Mb depending on the machine version. The recommended minimum memory is 12Mb. Each TAE Plus platform delivery tape includes pre-built libraries and executable binary code for that particular machine, as well as source code, so users do not have to do an installation. Users wishing to recompile the source will need both a C compiler and either GNU's C++ Version 1.39 or later, or a C++ compiler based on AT&T 2.0 cfront. TAE Plus was developed in 1989 and version 5.2 was released in 1993. TAE Plus 5.2 is available on media suitable for five different machine platforms: (1) IBM RS/6000 series workstations running AIX (.25 inch tape cartridge in UNIX tar format), (2) DEC RISC

Mortality and Causes of Death in Patients with Sporadic Inclusion Body Myositis: Survey Study Based on the Clinical Experience of Specialists in Australia, Europe and the USA

PubMed Central

Price, Mark A.; Barghout, Victoria; Benveniste, Olivier; Christopher-Stine, Lisa; Corbett, Alastair; de Visser, Marianne; Hilton-Jones, David; Kissel, John T.; Lloyd, Thomas E.; Lundberg, Ingrid E.; Mastaglia, Francis; Mozaffar, Tahseen; Needham, Merrilee; Schmidt, Jens; Sivakumar, Kumaraswamy; DeMuro, Carla; Tseng, Brian S.

2016-01-01

Background: There is a paucity of data on mortality and causes of death (CoDs) in patients with sporadic inclusion body myositis (sIBM), a rare, progressive, degenerative, inflammatory myopathy that typically affects those aged over 50 years. Objective: Based on patient records and expertise of clinical specialists, this study used questionnaires to evaluate physicians’ views on clinical characteristics of sIBM that may impact on premature mortality and CoDs in these patients. Methods: Thirteen physicians from seven countries completed two questionnaires online between December 20, 2012 and January 15, 2013. Responses to the first questionnaire were collated and presented in the second questionnaire to seek elaboration and identify consensus. Results: All 13 physicians completed both questionnaires, providing responses based on 585 living and 149 deceased patients under their care. Patients were reported to have experienced dysphagia (60.2%) and injurious falls (44.3%) during their disease. Over half of physicians reported that a subset of their patients with sIBM had a shortened lifespan (8/13), and agreed that bulbar dysfunction/dysphagia/oropharyngeal involvement (12/13), early-onset disease (8/13), severe symptoms (8/13), and falls (7/13) impacted lifespan. Factors related to sIBM were reported as CoDs in 40% of deceased patients. Oropharyngeal muscle dysfunction was ranked as the leading feature of sIBM that could contribute to death. The risk of premature mortality was higher than the age-matched comparison population. Conclusions: In the absence of data from traditional sources, this study suggests that features of sIBM may contribute to premature mortality and may be used to inform future studies. PMID:27854208

ISS Payload Racks Automated Flow Control Calibration Method

NASA Technical Reports Server (NTRS)

Simmonds, Boris G.

2003-01-01

Payload Racks utilize MTL and/or LTL station water for cooling of payloads and avionics. Flow control range from valves of fully closed, to up to 300 Ibmhr. Instrument accuracies are as high as f 7.5 Ibm/hr for flow sensors and f 3 Ibm/hr for valve controller, for a total system accuracy of f 10.5 Ibm/hr. Improved methodology was developed, tested and proven that reduces accuracy of the commanded flows to less than f 1 Ibmhr. Uethodology could be packed in a "calibration kit" for on- orbit flow sensor checkout and recalibration, extending the rack operations before return to earth. -

Using the Integrated Behavioral Model to Predict High-Risk Drinking among College Students

ERIC Educational Resources Information Center

Braun, Robert E.; Glassman, Tavis; Sheu, Jiunn-Jye; Dake, Joseph; Jordan, Tim; Yingling, Faith

2014-01-01

This study assessed the Integrated Behavioral Model's (IBM) utility in explaining high-risk drinking among college students. A total of 356 participants completed a four-page questionnaire based on the (IBM) theory and their drinking behavior. The results from a path analysis revealed three significant constructs (p<0.05) which predicted…

Reviews.

ERIC Educational Resources Information Center

Journal of Chemical Education, 1988

1988-01-01

Reviews two computer programs: "Molecular Graphics," which allows molecule manipulation in three-dimensional space (requiring IBM PC with 512K, EGA monitor, and math coprocessor); and "Periodic Law," a database which contains up to 20 items of information on each of the first 103 elements (Apple II or IBM PC). (MVL)

Personal-Computer Video-Terminal Emulator

NASA Technical Reports Server (NTRS)

Buckley, R. H.; Koromilas, A.; Smith, R. M.; Lee, G. E.; Giering, E. W.

1985-01-01

OWL-1200 video terminal emulator has been written for IBM Personal Computer. The OWL-1200 is a simple user terminal with some intelligent capabilities. These capabilities include screen formatting and block transmission of data. Emulator is written in PASCAL and Assembler for the IBM Personal Computer operating under DOS 1.1.

Modifying interpretation biases in body dysmorphic disorder: Evaluation of a brief computerized treatment.

PubMed

Summers, Berta J; Cougle, Jesse R

2016-12-01

Individuals meeting diagnostic criteria for body dysmorphic disorder (BDD; N = 40) were enrolled in a randomized, four-session trial comparing interpretation bias modification (IBM) training designed to target social evaluation- and appearance-related interpretation biases with a placebo control training condition (PC). Sessions took place over the course of two weeks (two sessions per week). Analyses indicated that, relative to the PC condition, IBM led to a significant increase in benign biases and reduction in threat biases at post-treatment. IBM also led to greater reductions in BDD symptoms compared to PC, though this effect was present at high but not low levels of pre-treatment BDD symptoms. Additionally, compared to PC, IBM led to lower urge to check and lower fear in response to an in vivo appearance-related stressor (having their picture taken from different angles), though the latter effect was present only among those reporting elevated fear at pre-treatment. The effects of treatment on interpretation biases and BDD symptoms were largely maintained at a one-month follow-up assessment. Moderated-mediation analyses showed that change in threat bias mediated the effect of condition on post-treatment symptoms for individuals high in pre-treatment BDD symptoms. The current study provides preliminary support for the efficacy of IBM for BDD. Copyright © 2016 Elsevier Ltd. All rights reserved.

Insulin-like growth factor I in inclusion-body myositis and human muscle cultures.

PubMed

Broccolini, Aldobrando; Ricci, Enzo; Pescatori, Mario; Papacci, Manuela; Gliubizzi, Carla; D'Amico, Adele; Servidei, Serenella; Tonali, Pietro; Mirabella, Massimiliano

2004-06-01

Possible pathogenic mechanisms of sporadic inclusion-body myositis (sIBM) include abnormal production and accumulation of amyloid beta (A beta), muscle aging, and increased oxidative stress. Insulin-like growth factor I (IGF-I), an endocrine and autocrine/paracrine trophic factor, provides resistance against A beta toxicity and oxidative stress in vitro and promotes cell survival. In this study we analyzed the IGF-I signaling pathway in sIBM muscle and found that 16.2% +/- 2.5% of nonregenerating fibers showed increased expression of IGF-I, phosphatidylinositide 3'OH-kinase, and Akt. In the majority of sIBM abnormal muscle fibers, increased IGF-I mRNA and protein correlated with the presence of A beta cytoplasmic inclusions. To investigate a possible relationship between A beta toxicity and IGF-I upregulation, normal primary muscle cultures were stimulated for 24 hours with the A beta(25-35) peptide corresponding to the biologically active domain of A beta. This induced an increase of IGF-I mRNA and protein in myotubes at 6 hours, followed by a gradual reduction thereafter. The level of phosphorylated Akt showed similar changes. We suggest that in sIBM. IGF-I overexpression represents a reactive response to A beta toxicity, possibly providing trophic support to vulnerable fibers. Understanding the signaling pathways activated by IGF-I in sIBM may lead to novel therapeutic strategies for the disease.

Preparing Future Teacher-Leaders: Experiences from the University of Connecticut's Five-Year Teacher Education Program

ERIC Educational Resources Information Center

Schwab, Richard L.; DeFranco, Thomas C.; McGivney-Burelle, Jean

2004-01-01

The article discusses the Integrated Bachelor's/Master's (IB/M) Teacher Preparation, a five-year teacher preparation program that integrates coursework, school-based clinic experiences, and university and K-12 faculty in the preparation of pre-service teachers. A major component of the IB/M program is the relationship with selected public school…

Elementary Technology Demonstration Schools: The Third Year 1992-93. Publication Number 92.31.

ERIC Educational Resources Information Center

Sabatino, Melissa

The 1992-93 school year was the third year of the Elementary Technology Demonstration Schools program of the Austin (Texas) schools; the project is funded by International Business Machines Corporation (IBM) and Apple Computer Inc. Grants from these corporations were used to equip three elementary schools with IBM equipment and one with Apple…

Computer program for calculating the flow field of supersonic ejector nozzles

NASA Technical Reports Server (NTRS)

Anderson, B. H.

1974-01-01

An analytical procedure for computing the performance of supersonic ejector nozzles is presented. This procedure includes real sonic line effects and an interaction analysis for the mixing process between the two streams. The procedure is programmed in FORTRAN 4 and has operated successfully on IBM 7094, IBM 360, CDC 6600, and Univac 1108.

PODIUM: Presentation Overlay Display for Interactive Uses of Media.

ERIC Educational Resources Information Center

Hofstetter, Fred T.

1989-01-01

Describes PODIUM, an educational software application that serves as a user interface to IBM's multimedia hardware. Faculty lecture outlines using IBM's InfoWindow and Audio Visual Connection (AVC) are explained for the fields of science, mathematics, music, and art, and a facility at the University of Delaware for using multimedia is described.…

TRAINING AND RESEARCH PROGRAM IN COMPUTER APPLICATIONS.

ERIC Educational Resources Information Center

HUNKA, S.

TO MAKE EDUCATIONAL RESEARCHERS AND TEACHERS MORE AWARE OF THE VALUES OF ELECTRONIC AUTOMATION, THIS ARTICLE PROPOSES A TRAINING-RESEARCH PROGRAM USING THE IBM 360/67 AND THE IBM 1500 COMPUTERS. PARTICIPANTS WOULD BE SELECTED FROM (1) POST-DOCTORAL AND PROFESSIONAL UNIVERSITY STAFF MEMBERS ON SABBATICAL LEAVE WHOSE MAIN INTEREST IS EDUCATIONAL…

Linking Resarch and Practice for Site-Based School Renewal.

ERIC Educational Resources Information Center

Castle, Shari; And Others

An analysis of the IBM/NEA Mastery in Learning (MIL) school renewal system, an electronic network that involves school faculties in collegial interaction with researchers and other educators in school reform, is the purpose of this paper. Developed by IBM (International Business Machines) and NEA (National Education Association), the MIL is a…

Physical properties and seismic structure of Izu-Bonin-Mariana fore-arc crust: Results from IODP Expedition 352 and comparison with oceanic crust

NASA Astrophysics Data System (ADS)

Christeson, G. L.; Morgan, S.; Kodaira, S.; Yamashita, M.; Almeev, R. R.; Michibayashi, K.; Sakuyama, T.; Ferré, E. C.; Kurz, W.

2016-12-01

Most of the well-preserved ophiolite complexes are believed to form in suprasubduction zone (SSZ) settings. We compare physical properties and seismic structure of SSZ crust at the Izu-Bonin-Mariana (IBM) fore arc with oceanic crust drilled at Holes 504B and 1256D to evaluate the similarities of SSZ and oceanic crust. Expedition 352 basement consists of fore-arc basalt (FAB) and boninite lavas and dikes. P-wave sonic log velocities are substantially lower for the IBM fore arc (mean values 3.1-3.4 km/s) compared to Holes 504B and 1256D (mean values 5.0-5.2 km/s) at depths of 0-300 m below the sediment-basement interface. For similar porosities, lower P-wave sonic log velocities are observed at the IBM fore arc than at Holes 504B and 1256D. We use a theoretical asperity compression model to calculate the fractional area of asperity contact Af across cracks. Af values are 0.021-0.025 at the IBM fore arc and 0.074-0.080 at Holes 504B and 1256D for similar depth intervals (0-300 m within basement). The Af values indicate more open (but not necessarily wider) cracks in the IBM fore arc than for the oceanic crust at Holes 504B and 1256D, which is consistent with observations of fracturing and alteration at the Expedition 352 sites. Seismic refraction data constrain a crustal thickness of 10-15 km along the IBM fore arc. Implications and inferences are that crust-composing ophiolites formed at SSZ settings could be thick and modified after accretion, and these processes should be considered when using ophiolites as an analog for oceanic crust.

The Ecology of the Mobile Worker. Workscape 21: The Ecology of New Ways of Working.

ERIC Educational Resources Information Center

Becker, Franklin; Quinn, Kristen L.; Callentine, Livit U.

A study addressed the impact of household composition--preschool, school-age, or no children--and nature of the home workspace--dedicated room or area--on IBM employees' satisfaction, stress, and work effectiveness. The IBM program allowed 300 employees who spent about 70 percent of their time with clients to work in home offices. Surveys,…

The Year of the Gifted Children.

ERIC Educational Resources Information Center

Kinney, Harrison

The article describes a program sponsored by International Business Machines Corporation (IBM) in which approximatey 60 children (14 to 17 years old) gifted in science spent much of 1941 after school hours in a science laboratory in IBM's showroom building. A number of these former students have achieved such positions as head of Goddard Space…

Administration of Computer Resources.

ERIC Educational Resources Information Center

Franklin, Gene F.

Computing at Stanford University has, until recently, been performed at one of five facilities. The Stanford hospital operates an IBM 370/135 mainly for administrative use. The university business office has an IBM 370/145 for its administrative needs and support of the medical clinic. Under the supervision of the Stanford Computation Center are…

Bringing Precision Medicine to Community Oncologists.

PubMed

2017-01-01

Quest Diagnostics has teamed up with Memorial Sloan Kettering Cancer Center and IBM Watson Health to offer IBM Watson Genomics to its network of community cancer centers and hospitals. This new service aims to advance precision medicine by combining genomic tumor sequencing with the power of cognitive computing. ©2017 American Association for Cancer Research.

Extreme Scale Computing Studies

DTIC Science & Technology

2010-12-01

PUBLICATION IN ACCORDANCE WITH ASSIGNED DISTRIBUTION STATEMENT. *//Signature// //Signature// KERRY HILL, Program Manager BRADLEY J ...Research Institute William Carlson Institute for Defense Analyses William Dally Stanford University Monty Denneau IBM T. J . Watson Research...for Defense Analyses William Dally, Stanford University Monty Denneau, IBM T. J . Watson Research Laboratories Paul Franzon, North Carolina State

CAI-BASIC: A Program to Teach the Programming Language BASIC.

ERIC Educational Resources Information Center

Barry, Thomas Anthony

A computer-assisted instruction (CAI) program was designed which fulfills the objectives of teaching a simple programing language, interpreting student responses, and executing and editing student programs. The CAI-BASIC program is written in FORTRAN IV and executes on IBM-2741 terminals while running under a time-sharing system on an IBM-360-70…

Inclusion body myositis.

PubMed

Dimachkie, Mazen M; Barohn, Richard J

2012-07-01

The idiopathic inflammatory myopathies are a group of rare disorders that share many similarities. These include dermatomyositis (DM), polymyositis (PM), necrotizing myopathy (NM), and sporadic inclusion body myositis (IBM). Inclusion body myositis is the most common idiopathic inflammatory myopathy after age 50 and it presents with chronic proximal leg and distal arm asymmetric mucle weakness. Despite similarities with PM, it is likely that IBM is primarily a degenerative disorder rather than an inflammatory muscle disease. Inclusion body myositis is associated with a modest degree of creatine kinase (CK) elevation and an abnormal electromyogram demonstrating an irritative myopathy with some chronicity. The muscle histopathology demonstrates inflammatory exudates surrounding and invading nonnecrotic muscle fibers often times accompanied by rimmed vacuoles. In this chapter, we review sporadic IBM. We also examine past, essentially negative, clinical trials in IBM and review ongoing clinical trials. For further details on DM, PM, and NM, the reader is referred to the idiopathic inflammatory myopathies chapter. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

ITER Plasma at Ion Cyclotron Frequency Domain: The Fusion Alpha Particles Diagnostics Based on the Stimulated Raman Scattering of Fast Magnetosonic Wave off High Harmonic Ion Bernstein Modes

NASA Astrophysics Data System (ADS)

Stefan, V. Alexander

2014-10-01

A novel method for alpha particle diagnostics is proposed. The theory of stimulated Raman scattering, SRS, of the fast wave and ion Bernstein mode, IBM, turbulence in multi-ion species plasmas, (Stefan University Press, La Jolla, CA, 2008). is utilized for the diagnostics of fast ions, (4)He (+2), in ITER plasmas. Nonlinear Landau damping of the IBM on fast ions near the plasma edge leads to the space-time changes in the turbulence level, (inverse alpha particle channeling). The space-time monitoring of the IBM turbulence via the SRS techniques may prove efficient for the real time study of the fast ion velocity distribution function, spatial distribution, and transport. Supported by Nikola Tesla Labs., La Jolla, CA 92037.

Technology and design of an active-matrix OLED on crystalline silicon direct-view display for a wristwatch computer

NASA Astrophysics Data System (ADS)

Sanford, James L.; Schlig, Eugene S.; Prache, Olivier; Dove, Derek B.; Ali, Tariq A.; Howard, Webster E.

2002-02-01

The IBM Research Division and eMagin Corp. jointly have developed a low-power VGA direct view active matrix OLED display, fabricated on a crystalline silicon CMOS chip. The display is incorporated in IBM prototype wristwatch computers running the Linus operating system. IBM designed the silicon chip and eMagin developed the organic stack and performed the back-end-of line processing and packaging. Each pixel is driven by a constant current source controlled by a CMOS RAM cell, and the display receives its data from the processor memory bus. This paper describes the OLED technology and packaging, and outlines the design of the pixel and display electronics and the processor interface. Experimental results are presented.

Isospin degree of freedom in even-even 68-76Ge and 62-70Zn isotopes

NASA Astrophysics Data System (ADS)

Jalili Majarshin, A.

2018-01-01

The introduction of isotopic spin is significant in light nuclei as Ge and Zn isotopes in order to take into account isospin effects on energy spectra. Dynamical symmetries in spherical, γ-soft limits and transition in the interacting boson model IBM-3 are analyzed. Analytic expressions and exact eigenenergies, electromagnetic transitions probabilities are obtained for the transition between spherical and γ-soft shapes by using the Bethe ansatz within an infinite-dimensional Lie algebra in light mass nuclei. The corresponding algebraic structure and reduction chain are studied in IBM-3. For examples, the nuclear structure of the 68-76Ge and 62-70Zn isotopes is calculated in IBM-3 and compared with experimental results.

Exploring Gender Differences in Predicting Physical Activity among Elementary Aged Children: An Application of the Integrated Behavioral Model

ERIC Educational Resources Information Center

Branscum, Paul; Bhochhibhoya, Amir

2016-01-01

Background: The integrated behavioral model (IBM) is a new and emerging theory in the field of health promotion and health education, and more applications are needed to test the usefulness of the model for research and practice. Purpose: The purpose of this study was to operationalize the IBM as it relates to physical activity (PA) among children…

Intrinsic states in the sdg interacting boson model

NASA Astrophysics Data System (ADS)

Yoshinaga, N.

1986-08-01

We give the intrinsic states explicitly in the boson representation in the framework of the sdg interacting boson model. Although they are only valid in the large- N limit, they are useful to estimate various physical quantities in well deformed nuclei. One can compare these results with those predicted in the IBM1 or in the IBM2.

77 FR 51573 - Certain Automated Media Library Devices; Determination To Review in Part a Final Initial...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-24

... convincing evidence that the IBM 3570, 3575, 7331, 7336 and 3494 documents qualify as printed publications.... To the extent the IBM 3570, 7331, 7336 and 3494 documents qualify as printed publications under 35 U... Elecs., Inc., 553 U.S. 617 (2008); LG Elecs., Inc. v. Bizcom Elecs., Inc., 453 F.3d 1364 (Fed. Cir. 2006...

Investigation of Single Events Upsets in Silicon and GaAs Structures Using Reaction Calculations

DTIC Science & Technology

1994-09-01

T.L. Criswell, D.L. Oberg, J.L. Wert, P.R. Measel , and W.E. Wilson, "Measurement of SEU Thresholds and Cross Sec- tions at Fixed Incidence Angles...WOOD ATTN: E KUBO ATTN: 0 MULKEY IBM CORP BOEING TECHNICAL & MANAGEMENT SVCS, INC ATTN: DEPT L75 ATTN: E NORMAND IBM CORP ATTN: P R MEASEL ATTN: A

The Impact of Computer-Based Training on Operating and Support Costs for the AN/SQQ-89 (v) Sonar System

DTIC Science & Technology

2013-04-01

Visibility and Management of Operating and Support Costs (VAMOSC), under Unit Level Consumption and Manhours—Organizational Corrective Maintenance...2007). LCMS Knowledgebase 2007: A comparison of 30+ Enterprise Learning Content Management Systems. Sunnyvale, CA: Brandon Hall Research. Chatham, R...School. IBM. (2011). Naval visibility and management of operating and support costs (VAMOSC; 10.3, ships, user manual). IBM. (2011). Naval

SNAP/SHOT Your Ability to Support That Next Application.

ERIC Educational Resources Information Center

Jones, Ernest L.

SNAP/SHOT (System Network Analysis Program-Simulated Host Overview Technique) is a discrete simulation of a network and/or host model available through IBM at the Raleigh System Center. The simulator provides an analysis of a total IBM Communications System. Input data must be obtained from RMF, SMF, and the CICS Analyzer to determine the existing…

Software Independent Verification and Validation (SIV&V) Simplified

DTIC Science & Technology

2006-12-01

Configuration Item I/O Input/Output I2V2 Independent Integrated Verification and Validation IBM International Business Machines ICD Interface...IPT Integrated Product Team IRS Interface Requirements Specification ISD Integrated System Diagram ITD Integrated Test Description ITP ...programming languages such as COBOL (Common Business Oriented Language) (Codasyl committee 1960), and FORTRAN (FORmula TRANslator) ( IBM 1952) (Robat 11

Analysis of sensitivity and uncertainty in an individual-based model of a threatened wildlife species

Treesearch

Bruce G. Marcot; Peter H. Singleton; Nathan H. Schumaker

2015-01-01

Sensitivity analysis—determination of how prediction variables affect response variables—of individual-based models (IBMs) are few but important to the interpretation of model output. We present sensitivity analysis of a spatially explicit IBM (HexSim) of a threatened species, the Northern Spotted Owl (NSO; Strix occidentalis caurina) in Washington...

Lessons from a decade of individual-based models for infectious disease transmission: a systematic review (2006-2015).

PubMed

Willem, Lander; Verelst, Frederik; Bilcke, Joke; Hens, Niel; Beutels, Philippe

2017-09-11

Individual-based models (IBMs) are useful to simulate events subject to stochasticity and/or heterogeneity, and have become well established to model the potential (re)emergence of pathogens (e.g., pandemic influenza, bioterrorism). Individual heterogeneity at the host and pathogen level is increasingly documented to influence transmission of endemic diseases and it is well understood that the final stages of elimination strategies for vaccine-preventable childhood diseases (e.g., polio, measles) are subject to stochasticity. Even so it appears IBMs for both these phenomena are not well established. We review a decade of IBM publications aiming to obtain insights in their advantages, pitfalls and rationale for use and to make recommendations facilitating knowledge transfer within and across disciplines. We systematically identified publications in Web of Science and PubMed from 2006-2015 based on title/abstract/keywords screening (and full-text if necessary) to retrieve topics, modeling purposes and general specifications. We extracted detailed modeling features from papers on established vaccine-preventable childhood diseases based on full-text screening. We identified 698 papers, which applied an IBM for infectious disease transmission, and listed these in a reference database, describing their general characteristics. The diversity of disease-topics and overall publication frequency have increased over time (38 to 115 annual publications from 2006 to 2015). The inclusion of intervention strategies (8 to 52) and economic consequences (1 to 20) are increasing, to the detriment of purely theoretical explorations. Unfortunately, terminology used to describe IBMs is inconsistent and ambiguous. We retrieved 24 studies on a vaccine-preventable childhood disease (covering 7 different diseases), with publication frequency increasing from the first such study published in 2008. IBMs have been useful to explore heterogeneous between- and within-host interactions, but

Inclusion Body Myositis: A Case Presenting with Respiratory Failure and Autopsy Findings Leading to the Hypothesis of a Paraneoplastic Cause.

PubMed

Dardis, Christopher; Antezana, Ariel; Tanji, Kurenai; Maccabee, Paul J

2017-06-23

BACKGROUND Sporadic inclusion body myositis (IBM) is the most common acquired myopathy seen in adults aged over 50 years, with a prevalence estimated at between 1 and 70 per million. Weakness of the diaphragm with loss of vital capacity is almost universal in IBM. This is almost always asymptomatic. When respiratory complications occur, they are most often due to aspiration. Respiratory failure due to diaphragmatic weakness is exceptionally rare, particularly as the presenting symptom of the disease. It is not currently considered to be a paraneoplastic syndrome. CASE REPORT Our patient presented with hypercarbic respiratory failure. This is the first such reported case without signs of weakness elsewhere of which we are aware. We suspected IBM based on her history of progressive weakness and findings on electromyography. There was a delay of 5 years in obtaining biopsy for confirmation, during which she presented with recurrent episodes of respiratory failure despite using non-invasive ventilation. An autopsy revealed the presence of papillary thyroid carcinoma with spread to local lymph nodes. On the basis that these co-morbidities are unlikely to have occurred by chance (we estimate 1×10-17), we hypothesize that IBM may be a paraneoplastic condition. We acknowledge that proof would require demonstrating a pathogenic antibody. CONCLUSIONS IBM should be considered in older patients (age >45) presenting with otherwise unexplained respiratory failure. A workup for possible malignancy in this setting appears reasonable.

Mesoangioblasts of inclusion-body myositis: a twofold tool to study pathogenic mechanisms and enhance defective muscle regeneration.

PubMed

Morosetti, R; Gliubizzi, C; Broccolini, A; Sancricca, C; Mirabella, M

2011-06-01

Mesoangioblasts are a class of adult stem cells of mesoderm origin, potentially useful for the treatment of primitive myopathies of different etiology. Extensive in vitro and in vivo studies in animal models of muscular dystrophy have demonstrated the ability of mesoangioblast to repair skeletal muscle when injected intra-arterially. In a previous work we demonstrated that mesoangioblasts obtained from diagnostic muscle biopsies of IBM patients display a defective differentiation down skeletal muscle and this block can be corrected in vitro by transient MyoD transfection. We are currently investigating different pathways involved in mesoangioblasts skeletal muscle differentiation and exploring alternative stimulatory approaches not requiring extensive cell manipulation. This will allow to obtain safe, easy and efficient molecular or pharmacological modulation of pro-myogenic pathways in IBM mesoangioblasts. It is of crucial importance to identify factors (ie. cytokines, growth factors) produced by muscle or inflammatory cells and released in the surrounding milieu that are able to regulate the differentiation ability of IBM mesoangioblasts. To promote myogenic differentiation of endogenous mesoangioblasts in IBM muscle, the modulation of such target molecules selectively dysregulated would be a more handy approach to enhance muscle regeneration compared to transplantation techniques. Studies on the biological characteristics of IBM mesoangioblasts with their aberrant differentiation behavior, the signaling pathways possibly involved in their differentiation block and the possible strategies to overcome it in vivo, might provide new insights to better understand the etiopathogenesis of this crippling disorder and to identify molecular targets susceptible of therapeutic modulation.

Optoelectric Technology Roadmap: Conclusions and Recommendations

DTIC Science & Technology

1994-05-01

Haitz Hughes Adrian Popa Robert Buckley IBM Maurizio Arienzo John Crow NYNEX Robert Lawrence Motorola Ron Nelson 3M Charles T. Walker OPTOELECTRONIC...Bellcore (1) Industrial Mark Chandler, Hewlett-Packard Military/Aerospace Richard Lind, Hughes Luis Figueroa , Boeing Computer John Crow, IBM...Bellcore William Womack AT&T Matt Goodman Bellcore Dwight Duston BMDO Paul Shumate Bellcore Luis Figueroa Boeing Richard Jones Broadband Technologies

An Evaluation of Alternative Delivery Modes for Information Services.

ERIC Educational Resources Information Center

Short, Craig; Christal, Melodie E.

The use of the floppy disk as an alternative mode for delivering Information Services reports was evaluated for fiscal year 1985 by the National Center for Higher Education Management Systems (NCHEMS). A 5.25 inch, 8/9 sector, 40 track ASCII floppy disk used under PC-DOS on the IBM PC and IBM PC compatible hardware was tested. Tabular data but not…

Analysis of Carbon Nanotube Field-Effect-Transistors (FETs)

NASA Technical Reports Server (NTRS)

Yamada, Toshishige

1999-01-01

This five page presentation is grouped into 11 numbered viewgraphs, most of which contain one or more diagrams. Some of the diagrams are accompanied by captions, including: 2) Nanotube FET by Delft, IBM; 3) Nanotube FET/Standard MOSFET; 5) Saturation with carrier-carrier; 7) Electronic properties of carbon nanotube; 8) Theoretical nanotube FET characteristics; 11) Summary: Delft and IBM nanotube FET analysis.

Integral Ramjet Booster Demonstration Program

DTIC Science & Technology

1975-02-01

Table 3-10 THREE-COMPONENT DECOMPOSITION MODEL Component r0 Ibm ;"-3 7ft Ibm ^ft A (Resin) 60.75 B (Resin) 20.24 C (Reinf.) 110.00...Cured Strands Burn rate 1000 psia/ + 70°F, in./sec Pressure exponent o. (-65 to +1600F), %/"F itP , (-65 to tUCF), ü/8» Ballistic Properties, 6

Study of the 190Hg Nucleus: Testing the Existence of U(5) Symmetry

NASA Astrophysics Data System (ADS)

Jahangiri Tazekand, Z.; Mohseni, M.; Mohammadi, M. A.; Sabri, H.

2018-06-01

In this paper, we have considered the energy spectra, quadrupole transition probabilities, energy surface, charge radii, and quadrupole moment of the190Hg nucleus to describe the interplay between phase transitions and configuration mixing of intruder excitations. To this aim, we have used four different formalisms: (i) interacting boson model including configuration mixing, (ii) Z(5) critical symmetry, (iii) U(6)-based transitional Hamiltonian, and (iv) a transitional interacting boson model Hamiltonian in both interacting boson model (IBM)-1 and IBM-2 versions which are based on affine \\widehat{SU(1,1)} Lie algebra. Results show the advantages of configuration mixing and transitional Hamiltonians, in particular IBM-2 formalism, to reproduce the experimental counterparts when the weight of spherical symmetry increased.

Upper Atmosphere Research Satellite (UARS) trade analysis

NASA Technical Reports Server (NTRS)

Fox, M. M.; Nebb, J.

1983-01-01

The Upper Atmosphere Research Satellite (UARS) which will collect data pertinent to the Earth's upper atmosphere is described. The collected data will be sent to the central data handling facility (CDHF) via the UARS ground system and the data will be processed and distributed to the remote analysis computer systems (RACS). An overview of the UARS ground system is presented. Three configurations were developed for the CDHF-RACS system. The CDHF configurations are discussed. The IBM CDHF configuration, the UNIVAC CDHF configuration and the vax cluster CDHF configuration are presented. The RACS configurations, the IBM RACS configurations, UNIVAC RACS and VAX RACS are detailed. Due to the large on-line data estimate to approximately 100 GB, a mass storage system is considered essential to the UARS CDHF. Mass storage systems were analyzed and the Braegan ATL, the RCA optical disk, the IBM 3850 and the MASSTOR M860 are discussed. It is determined that the type of mass storage system most suitable to UARS is the automated tape/cartridge device. Two devices of this type, the IBM 3850 and the MASSTOR MSS are analyzed and the applicable tape/cartridge device is incorporated into the three CDHF-RACS configurations.

PubMed Central

Broccolini, A.; Gidaro, T.; Morosetti, R.; Sancricca, C.; Mirabella, M.

2011-01-01

The hereditary inclusion-body myopathies encompass several syndromes with autosomal recessive or dominant inheritance. Despite a different clinical presentation they all have a progressive course leading to severe disability and share similar pathologic findings at the muscle biopsy. Quadriceps-sparing autosomal recessive hereditary inclusion-body myopathy (h-IBM) is the commonest form and is tied to mutations of the UDP-Nacetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) that codes for a rate-limiting enzyme in the sialic acid biosynthetic pathway. Despite the identification of the causative gene defect, it has not been clarified how mutations of the GNE gene impair muscle homeostasis. Although several lines of evidence argue in favor of an abnormal sialylation of muscle glycoproteins playing a key role in h-IBM pathogenesis, others studies have demonstrated new functions of the GNE gene, outside the sialic acid biosynthetic pathway, that may also be relevant. This review illustrates the clinical and pathologic characteristics of h- IBM and the main clues available to date concerning the possible pathogenic mechanisms of this disorder. Understanding the molecular mechanism underlying h-IBM pathology is a fundamental requisite to plan a future attempt to therapy. PMID:22106710

Hereditary inclusion-body myopathy with sparing of the quadriceps: the many tiles of an incomplete puzzle.

PubMed

Broccolini, A; Gidaro, T; Morosetti, R; Sancricca, C; Mirabella, M

2011-10-01

The hereditary inclusion-body myopathies encompass several syndromes with autosomal recessive or dominant inheritance. Despite a different clinical presentation they all have a progressive course leading to severe disability and share similar pathologic findings at the muscle biopsy. Quadriceps-sparing autosomal recessive hereditary inclusion-body myopathy (h-IBM) is the commonest form and is tied to mutations of the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) that codes for a rate-limiting enzyme in the sialic acid biosynthetic pathway. Despite the identification of the causative gene defect, it has not been clarified how mutations of the GNE gene impair muscle homeostasis. Although several lines of evidence argue in favor of an abnormal sialylation of muscle glycoproteins playing a key role in h-IBM pathogenesis, others studies have demonstrated new functions of the GNE gene, outside the sialic acid biosynthetic pathway, that may also be relevant. This review illustrates the clinical and pathologic characteristics of h-IBM and the main clues available to date concerning the possible pathogenic mechanisms of this disorder. Understanding the molecular mechanism underlying h-IBM pathology is a fundamental requisite to plan a future attempt to therapy.

Combining Individual-Based Modeling and Food Microenvironment Descriptions To Predict the Growth of Listeria monocytogenes on Smear Soft Cheese

PubMed Central

Ferrier, Rachel; Hezard, Bernard; Lintz, Adrienne; Stahl, Valérie

2013-01-01

An individual-based modeling (IBM) approach was developed to describe the behavior of a few Listeria monocytogenes cells contaminating smear soft cheese surface. The IBM approach consisted of assessing the stochastic individual behaviors of cells on cheese surfaces and knowing the characteristics of their surrounding microenvironments. We used a microelectrode for pH measurements and micro-osmolality to assess the water activity of cheese microsamples. These measurements revealed a high variability of microscale pH compared to that of macroscale pH. A model describing the increase in pH from approximately 5.0 to more than 7.0 during ripening was developed. The spatial variability of the cheese surface characterized by an increasing pH with radius and higher pH on crests compared to that of hollows on cheese rind was also modeled. The microscale water activity ranged from approximately 0.96 to 0.98 and was stable during ripening. The spatial variability on cheese surfaces was low compared to between-cheese variability. Models describing the microscale variability of cheese characteristics were combined with the IBM approach to simulate the stochastic growth of L. monocytogenes on cheese, and these simulations were compared to bacterial counts obtained from irradiated cheeses artificially contaminated at different ripening stages. The simulated variability of L. monocytogenes counts with the IBM/microenvironmental approach was consistent with the observed one. Contrasting situations corresponding to no growth or highly contaminated foods could be deduced from these models. Moreover, the IBM approach was more effective than the traditional population/macroenvironmental approach to describe the actual bacterial behavior variability. PMID:23872572

Inclusion Body Myositis: A Case Presenting with Respiratory Failure and Autopsy Findings Leading to the Hypothesis of a Paraneoplastic Cause

PubMed Central

Dardis, Christopher; Antezana, Ariel; Tanji, Kurenai; Maccabee, Paul

2017-01-01

Patient: Female, 48 Final Diagnosis: Inclusion body myositis Symptoms: Shortness of breath • weakness Medication: — Clinical Procedure: Biopsy Specialty: Neurology Objective: Rare disease Background: Sporadic inclusion body myositis (IBM) is the most common acquired myopathy seen in adults aged over 50 years, with a prevalence estimated at between 1 and 70 per million. Weakness of the diaphragm with loss of vital capacity is almost universal in IBM. This is almost always asymptomatic. When respiratory complications occur, they are most often due to aspiration. Respiratory failure due to diaphragmatic weakness is exceptionally rare, particularly as the presenting symptom of the disease. It is not currently considered to be a paraneoplastic syndrome. Case Report: Our patient presented with hypercarbic respiratory failure. This is the first such reported case without signs of weakness elsewhere of which we are aware. We suspected IBM based on her history of progressive weakness and findings on electromyography. There was a delay of 5 years in obtaining biopsy for confirmation, during which she presented with recurrent episodes of respiratory failure despite using non-invasive ventilation. An autopsy revealed the presence of papillary thyroid carcinoma with spread to local lymph nodes. On the basis that these co-morbidities are unlikely to have occurred by chance (we estimate 1×10−17), we hypothesize that IBM may be a paraneoplastic condition. We acknowledge that proof would require demonstrating a pathogenic antibody. Conclusions: IBM should be considered in older patients (age >45) presenting with otherwise unexplained respiratory failure. A workup for possible malignancy in this setting appears reasonable. PMID:28642454

X-ray mask fabrication advancements at the Microlithographic Mask Development Center

NASA Astrophysics Data System (ADS)

Kimmel, Kurt R.; Hughes, Patrick J.

1996-05-01

The Microlithographic Mask Development Center (MMD) was established as the X-ray mask manufacturing facility at the IBM Microelectronics Division semiconductor fabricator in Essex Junction, Vermont. This center, in operation for over two years, produces high yielding, defect-free X-ray masks for competitive logic and memory products at 250nm groundrules and below. The MMD is a complete mask facility that manufactures silicon membrane mask blanks in the NIST format and finished masks with electroplated gold X-ray absorber. Mask patterning, with dimensions as small as 180 nm, is accomplished using IBM-built variable shaped spot e-beam systems. Masks are routinely inspected and repaired using state-of-the-art equipment: two KLA SEM Specs for defect inspection, a Leica LMS 2000 for image placement characterization, an Amray 2040c for image dimension characterization and a Micrion 8000 XMR for defect repair. This facility maintains a baseline mask process with daily production of 250nm, 32Mb SRAM line monitor masks for the continuous improvement of mask quality and processes. Development masks are produced for several semiconductor manufacturers including IBM, Motorola, Loral, and Sanders. Masks for 64Mb and 256Mb DRAM (IBM) and advanced logic/SRAM (IBM and Motorola) designs have also been delivered. This paper describes the MMD facility and its technical capabilities. Key manufacturing metrics such as mask turnaround time, parametric yield learning and defect reduction activities are highlighted. The challenges associated with improved mask quality, sub-180nm mask fabrication, and the transition to refractory metal absorber are discussed.

PubMed Central

MOROSETTI, R.; GLIUBIZZI, C.; BROCCOLINI, A.; SANCRICCA, C.; MIRABELLA, M.

2011-01-01

SUMMARY Mesoangioblasts are a class of adult stem cells of mesoderm origin, potentially useful for the treatment of primitive myopathies of different etiology. Extensive in vitro and in vivo studies in animal models of muscular dystrophy have demonstrated the ability of mesoangioblast to repair skeletal muscle when injected intra-arterially. In a previous work we demonstrated that mesoangioblasts obtained from diagnostic muscle biopsies of IBM patients display a defective differentiation down skeletal muscle and this block can be corrected in vitro by transient MyoD transfection. We are currently investigating different pathways involved in mesoangioblasts skeletal muscle differentiation and exploring alternative stimulatory approaches not requiring extensive cell manipulation. This will allow to obtain safe, easy and efficient molecular or pharmacological modulation of pro-myogenic pathways in IBM mesoangioblasts. It is of crucial importance to identify factors (ie. cytokines, growth factors) produced by muscle or inflammatory cells and released in the surrounding milieu that are able to regulate the differentiation ability of IBM mesoangioblasts. To promote myogenic differentiation of endogenous mesoangioblasts in IBM muscle, the modulation of such target molecules selectively dysregulated would be a more handy approach to enhance muscle regeneration compared to transplantation techniques. Studies on the biological characteristics of IBM mesoangioblasts with their aberrant differentiation behavior, the signaling pathways possibly involved in their differentiation block and the possible strategies to overcome it in vivo, might provide new insights to better understand the etiopathogenesis of this crippling disorder and to identify molecular targets susceptible of therapeutic modulation. PMID:21842589

Analysis of NCAM helps identify unusual phenotypes of hereditary inclusion-body myopathy.

PubMed

Broccolini, A; Gidaro, T; Tasca, G; Morosetti, R; Rodolico, C; Ricci, E; Mirabella, M

2010-07-20

Hereditary inclusion-body myopathy or distal myopathy with rimmed vacuoles (h-IBM/DMRV) is due to mutations of the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) gene, which codes for an enzyme of the sialic acid biosynthetic pathway. By Western blot (WB) analysis, we have previously shown that in h-IBM/DMRV muscle, the neural cell adhesion molecule (NCAM) has increased electrophoretic mobility that reflects reduced sialylation of the protein. To identify patients with h-IBM/DMRV with atypical clinical or pathologic phenotype using NCAM analysis and the possible cellular mechanism associated with the overall abnormal sialylation of NCAM observed in this disorder. WB analysis of NCAM was performed on muscle biopsies of 84 patients with an uncharacterized muscle disorder who were divided in the following 2 groups: 1) 46 patients with a proximal muscle weakness in whom the main limb-girdle muscular dystrophy syndromes had been ruled out; and 2) 38 patients with a distal distribution of weakness in whom a neurogenic affection had been excluded. Patients in whom a reduced sialylation of NCAM was suspected were studied for the presence of GNE mutations. In 3 patients, we found that NCAM had increased electrophoretic mobility, thus suggesting an abnormal sialylation of the protein. The genetic study demonstrated that they all carried pathogenic GNE mutations. Further studies demonstrated that hyposialylated NCAM, showing increased electrophoretic mobility on WB, is expressed by nonregenerating fibers in h-IBM/DMRV muscle. WB analysis of NCAM may be instrumental in the identification of h-IBM/DMRV with atypical clinical or pathologic features.

Comparison of individual-based modeling and population approaches for prediction of foodborne pathogens growth.

PubMed

Augustin, Jean-Christophe; Ferrier, Rachel; Hezard, Bernard; Lintz, Adrienne; Stahl, Valérie

2015-02-01

Individual-based modeling (IBM) approach combined with the microenvironment modeling of vacuum-packed cold-smoked salmon was more effective to describe the variability of the growth of a few Listeria monocytogenes cells contaminating irradiated salmon slices than the traditional population models. The IBM approach was particularly relevant to predict the absence of growth in 25% (5 among 20) of artificially contaminated cold-smoked salmon samples stored at 8 °C. These results confirmed similar observations obtained with smear soft cheese (Ferrier et al., 2013). These two different food models were used to compare the IBM/microscale and population/macroscale modeling approaches in more global exposure and risk assessment frameworks taking into account the variability and/or the uncertainty of the factors influencing the growth of L. monocytogenes. We observed that the traditional population models significantly overestimate exposure and risk estimates in comparison to IBM approach when contamination of foods occurs with a low number of cells (<100 per serving). Moreover, the exposure estimates obtained with the population model were characterized by a great uncertainty. The overestimation was mainly linked to the ability of IBM to predict no growth situations rather than the consideration of microscale environment. On the other hand, when the aim of quantitative risk assessment studies is only to assess the relative impact of changes in control measures affecting the growth of foodborne bacteria, the two modeling approach gave similar results and the simplest population approach was suitable. Copyright © 2014 Elsevier Ltd. All rights reserved.

FMS: A Format Manipulation System for Automatic Production of Natural Language Documents, Second Edition. Final Report.

ERIC Educational Resources Information Center

Silver, Steven S.

FMS/3 is a system for producing hard copy documentation at high speed from free format text and command input. The system was originally written in assembler language for a 12K IBM 360 model 20 using a high speed 1403 printer with the UCS-TN chain option (upper and lower case). Input was from an IBM 2560 Multi-function Card Machine. The model 20…

Purchasing a Computer System for the Small Construction Company,

DTIC Science & Technology

1983-06-08

October 1982. . . . . . . .. i. i...< ..- . ,. .-: i. i? ,. . .-- i * i . . . ., r77- 7 *,~ .- -- 36 IBM - International Business Machines...Corporation, "Small Systems Solutions: An Introduction to Business Computing," Pamphlet SC21-5205-0, Atlanta, Georgia, January 1979. International Business Machines...Corporation, "IBM System/34 Introduction," Pamphlet GC21-5153-5, File No. S34-00, Atlanta, Georgia, January 1979. International Business Machines

Interfacial and Thin Film Chemistry in Electron Device Fabrication

DTIC Science & Technology

1990-11-20

mounted on our UHV surface analysis system, and J. Forster and D. V. Podlesnik of the IBM General Technology Division. The following discussion...IBM (East Fishkill). The system being built consists of three chambers: one UHV analysis chamber, one UHV reaction chamber and one high pressure...system will be equipped with several surface analysis and cleaning techniques. Fourier transform infrared spectrometry will be used to do attenuated

Effect of Maximal Apnoea Easy-Going and Struggle Phases on Subarachnoid Width and Pial Artery Pulsation in Elite Breath-Hold Divers.

PubMed

Winklewski, Pawel J; Barak, Otto; Madden, Dennis; Gruszecka, Agnieszka; Gruszecki, Marcin; Guminski, Wojciech; Kot, Jacek; Frydrychowski, Andrzej F; Drvis, Ivan; Dujic, Zeljko

2015-01-01

The aim of the study was to assess changes in subarachnoid space width (sas-TQ), the marker of intracranial pressure (ICP), pial artery pulsation (cc-TQ) and cardiac contribution to blood pressure (BP), cerebral blood flow velocity (CBFV) and cc-TQ oscillations throughout the maximal breath hold in elite apnoea divers. Non-invasive assessment of sas-TQ and cc-TQ became possible due to recently developed method based on infrared radiation, called near-infrared transillumination/backscattering sounding (NIR-T/BSS). The experimental group consisted of seven breath-hold divers (six men). During testing, each participant performed a single maximal end-inspiratory breath hold. Apnoea consisted of the easy-going and struggle phases (characterised by involuntary breathing movements (IBMs)). Heart rate (HR) was determined using a standard ECG. BP was assessed using the photoplethysmography method. SaO2 was monitored continuously with pulse oximetry. A pneumatic chest belt was used to register thoracic and abdominal movements. Cerebral blood flow velocity (CBFV) was estimated by a 2-MHz transcranial Doppler ultrasonic probe. sas-TQ and cc-TQ were measured using NIR-T/BSS. Wavelet transform analysis was performed to assess cardiac contribution to BP, CBFV and cc-TQ oscillations. Mean BP and CBFV increased compared to baseline at the end of the easy phase and were further augmented by IBMs. cc-TQ increased compared to baseline at the end of the easy phase and remained stable during the IBMs. HR did not change significantly throughout the apnoea, although a trend toward a decrease during the easy phase and recovery during the IBMs was visible. Amplitudes of BP, CBFV and cc-TQ were augmented. sas-TQ and SaO2 decreased at the easy phase of apnoea and further decreased during the IBMs. Apnoea increases intracranial pressure and pial artery pulsation. Pial artery pulsation seems to be stabilised by the IBMs. Cardiac contribution to BP, CBFV and cc-TQ oscillations does not change

Workshop on the Road to Room Temperature Superconductivity

DTIC Science & Technology

1993-01-14

703-693-1695 650 Harry Road San Jose, CA 95120 Mitzi , Dr. David Tel: 408-927-2434 IBM, Thomas J. Watson Research Fax: 408-927-2100 Center P. 0. Box 218...6:00 Kivelson Fisk: Mitzi : Gorkov: comments 7:30 - 9:30 urphl Torrance - conductivity and superconductivity (oxides) Williams: conductivity and...should develop a better gleanedfromexperimentandtheoryasguides. D. Mitzi (IBM Yorktown Heights) dis- theoretical understanding of highly corre- As the

Advanced CMOS Radiation Effects Testing and Analysis

NASA Technical Reports Server (NTRS)

Pellish, J. A.; Marshall, P. W.; Rodbell, K. P.; Gordon, M. S.; LaBel, K. A.; Schwank, J. R.; Dodds, N. A.; Castaneda, C. M.; Berg, M. D.; Kim, H. S.;

Hypermetabolism as a Risk Factor for ALS

DTIC Science & Technology

2013-09-01

hIBM) and sporadic Inclusion Body Myositis (sIBM). These disorders are characterized clinically by progressive muscle degeneration and weakness that...1186–1189 (2008). 3. Lloyd, T. E. Novel therapeutic approaches for inclusion body myositis . Current Opinion in Rheumatology 22, 658–664 (2010). 4...46, 424–430 (2008). 8. Weihl, C. C. & Pestronk, A. Sporadic inclusion body myositis : possible pathogenesis inferred from biomarkers. Curr Opin

A Review of Software Maintenance Technology.

DTIC Science & Technology

1980-02-01

LABS HONEYWELL, REF BURROUGHS, OTHERS BOOLE £ LANGUAGE "PE BABBAGE , OPERATIONAL INDEPENDENT 4.2.17 INC. IBM H M RELIABILITY MOST LARGE U. MEASUREMENT...80-13 ML llluuluunuuuuu SmeeI..... f. Maintenance Experience (1) Multiple Implementation Charles Holmes (Source 2) described two attempts at McDonnell...proprietary software monitor package distributed by Boole and Babbage , Inc., Sunnyvale, California. it has been implemented on IBM computers and is language

Extending the Kerberos Protocol for Distributed Data as a Service

DTIC Science & Technology

2012-09-20

exported as a UIMA [11] PEAR file for deployment to IBM Content Analytics (ICA). A UIMA PEAR file is a deployable text analytics “pipeline” (analogous...to a web application packaged in a WAR file). ICA is a text analysis and search application that supports UIMA . The key entities targeted by NLP rules...workbench. [Online]. Available: https: //www.ibm.com/developerworks/community/alphaworks/lrw/ [11] Apache UIMA . [Online]. Available: http

Integrating the Nqueens Algorithm into a Parameterized Benchmark Suite

DTIC Science & Technology

2016-02-01

FOB is a 64-node heterogeneous cluster consisting of 16-IBM dx360M4 nodes, each with one NVIDIA Kepler K20M GPUs and 48-IBM dx360M4 nodes, and each...nodes have 256-GB of memory and an NVIDIA Tesla K40 GPU. More details on Excalibur can be found on the US Army DSRC website.19 Figures 3 and 4 show the

Trench Advance By the Subduction of Buoyant Features - Application to the Izu-Bonin-Marianas Arc

NASA Astrophysics Data System (ADS)

Goes, S. D. B.; Fourel, L.; Morra, G.

2014-12-01

Most subduction trenches retreat, not only today but throughout the Cenozoic. However, a few trenches clearly advance during part of the evolution, including Izu-Bonin Marianas (IBM) and Kermadec. Trench retreat is well understood as a basic consequence of slab pull, but it is debated what causes trench advance. The IBM trench underwent a complex evolution: right after its initiation, it rotated clockwise, leading to very fast retreat in the north and slow retreat in the south. But since 10-15 Ma, IBM trench motions have switched to advance at the southern end, and since 5 Ma also the northern end is advancing. Based on 2-D subduction models, it has been proposed proposed that the change in age of the subducting plate at the IBM trench (from 40-70 m.y. at the initiation of the trench 45 m.y. ago to 100-140 m.y. lithosphere subducting at the trench today) and its effect on plate strength could explain the transition from trench retreat to trench advance, and that the age gradient (younger in the north and older in the south) could explain the rotation of the trench. However, with new 3-D coupled fluid-solid subduction model where we can include such lateral age gradients, we find that this does not yield the observed behaviour. Instead, we propose an alternative mechanism, involving the subduction of the buoyant Caroline Island Ridge at the southern edge of the Mariana trench and show that it can explain both trench motion history and the current morphology of the IBM slab as imaged by seismic tomography.

Inclusive business model in tapioca starch industry in Lake Toba area: a case study

NASA Astrophysics Data System (ADS)

Tampubolon, S.; Manik, Y.

2018-04-01

The notion of inclusive business calls for additional focus and innovation in the way companies do business which seeks to contribute to poverty alleviation by including Bottom of the Pyramids (BoP) communities within its value chain while not losing sight of the ultimate goal of business. Lake Toba Area has potentials in providing chances for doing businesses. On the other hand, the growth of market size is rather slow and demographically still dominated by BoP. This is a case study which seeks to investigate to what extent the Inclusive Business Model (IBM) is adopted in the strategic planning and applied in the operational management of companies that operate in Lake Toba Area. The study was conducted in qualitative basis. The observation was conducted by gathering data and information through a series of interviews with the top management and desk study of the business plan in a tapioca starch industry in Toba Samosir Regency. The collected data and information were then analyzed qualitatively by comparing them with criteria and parameters of IBM suggested in a vast body of literature. The reference by which the IBM is referred in this study is a series of criteria which is synthesized from a literature review on a vast body of literature about IBM. From data analysis, it is evident that IBM has been incorporated in the strategic plan and applied in the operational activities of the object of this study. However, we also found some rooms for improvement such as expanding the involvement of BoP in their value chain as consumers, by which some innovation in the product diversification is required.

WATEQ4F - a personal computer Fortran translation of the geochemical model WATEQ2 with revised data base

USGS Publications Warehouse

Ball, J.W.; Nordstrom, D. Kirk; Zachmann, D.W.

1987-01-01

A FORTRAN 77 version of the PL/1 computer program for the geochemical model WATEQ2, which computes major and trace element speciation and mineral saturation for natural waters has been developed. The code (WATEQ4F) has been adapted to execute on an IBM PC or compatible microcomputer. Two versions of the code are available, one operating with IBM Professional FORTRAN and an 8087 or 89287 numeric coprocessor, and one which operates without a numeric coprocessor using Microsoft FORTRAN 77. The calculation procedure is identical to WATEQ2, which has been installed on many mainframes and minicomputers. Limited data base revisions include the addition of the following ions: AlHS04(++), BaS04, CaHS04(++), FeHS04(++), NaF, SrC03, and SrHCO3(+). This report provides the reactions and references for the data base revisions, instructions for program operation, and an explanation of the input and output files. Attachments contain sample output from three water analyses used as test cases and the complete FORTRAN source listing. U.S. Geological Survey geochemical simulation program PHREEQE and mass balance program BALANCE also have been adapted to execute on an IBM PC or compatible microcomputer with a numeric coprocessor and the IBM Professional FORTRAN compiler. (Author 's abstract)

The third level trigger and output event unit of the UA1 data-acquisition system

NASA Astrophysics Data System (ADS)

Cittolin, S.; Demoulin, M.; Fucci, A.; Haynes, W.; Martin, B.; Porte, J. P.; Sphicas, P.

1989-12-01

The upgraded UA1 experiment utilizes twelve 3081/E emulators for its third-level trigger system. The system is interfaced to VME, and is controlled by 68000 microprocessor VME boards on the input and output. The output controller communicates with an IBM 9375 mainframe via the CERN-IBM developed VICI interface. The events selected by the emulators are output on IBM-3480 cassettes. The user interface to this system is based on a series of Macintosh personal computer connected to the VME bus. These Macs are also used for developing software for the emulators and for monitoring the entire system. The same configuration has also been used for offline event reconstruction. A description of the system, together with details of both the online and offline modes of operation and an eveluation of its performance are presented.

B(IS4; 0{GS/+}→4{/γ +}) systematics in rare-earth nuclei: SUsdg (3) description

NASA Astrophysics Data System (ADS)

Devi, Y. D.; Kota, V. K. B.

1993-12-01

The observed variation of B(IS4; 0{GS/+}→{/γ +}) with mass number A, that gives information about hexadecupole component in γ-vibration, in rare-earth nuclei is studied in the SUsdg (3) limit of sdg interacting boson model employing IBM-2 to IBM-1 projected hexadecupole transition operator with effective charges determined using a multi- j shell mapping procedure. The SUsdg (3) limit provides a reasonably good description of the data.

A Comparison of Priority-based and Incremental Real-Time Garbage Collectors in the Implementation of the Shadow Design Pattern

DTIC Science & Technology

2008-08-15

running the real-time application we used in our previous study on IBM WebSphere Real Time. IBM WebSphere Real Time automatically sets Metronome , its...the experiment show that the modified code for the Shadow Design Pattern runs well under Metronome . 15. NUMBER OF PAGES 25 14. SUBJECT TERMS...includes the real-time garbage collector called the Metronome . Unlike the Sun RTGC, we cannot change the priority of the Metronome RTGC. Metronome is

Balancing Value and Risk in Information Sharing Through Obfuscation

DTIC Science & Technology

2012-09-20

California, Los Angeles Chatschik Bisdikian IBM T.J. Watson Research Center Lance M. Kaplan US Army Research Laboratory Abstract—Fast-paced data-to...AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) IBM T.J. Watson Research...giving us annotations for both the white listed activity detection as well as the black listed activity recognition . We implemented five features

Flow Characteristics of a Multiple Nozzle Exhaust Gas Eductor System.

DTIC Science & Technology

1981-03-01

these exhaust gases are a temperatures significantly above those of conventionally powered ships. A few of the problems caused by these high temperatures ...systems designed for marine gas turbine applications must substantially cool exhaust gases , present an exterior stack surface temperature which will not...stack in. H 02 R - Gas constant for air, 53.34 ft-lbf/Ibm-R s - Entropy, Btu/Ibm-R S - Primary dimension of mixing stack T - Absolute temperature , R

Proceedings of the Seminar on the DoD Computer Security Initiative Program, National Bureau of Standards, Gaithersburg, Maryland, July 17-18, 1979.

DTIC Science & Technology

1979-01-01

specifications have been prepared for a DoD communications processor on an IBM minicomputer, a minicomputer time sharing system for the DEC PDP-11 and...the Honeywell Level 6. a virtual machine monitor for the IBM 370, and Multics [10] for the Honeywell Level 68. MECHANISMS FOR KERNEL IMPLEMENTATION...HOL INA ZJO : ANERIONS g PROCESSORn , c ...THEOREMS 1 ITP I-THEOREMS PROOF EVIDENCE - p II KV./370 FORMAL DESIGN PROCESS M4ODULAR DECOMPOSITION * NON

Menu-Driven Solver Of Linear-Programming Problems

NASA Technical Reports Server (NTRS)

Viterna, L. A.; Ferencz, D.

1992-01-01

Program assists inexperienced user in formulating linear-programming problems. A Linear Program Solver (ALPS) computer program is full-featured LP analysis program. Solves plain linear-programming problems as well as more-complicated mixed-integer and pure-integer programs. Also contains efficient technique for solution of purely binary linear-programming problems. Written entirely in IBM's APL2/PC software, Version 1.01. Packed program contains licensed material, property of IBM (copyright 1988, all rights reserved).

A Survey of Videodisc Technology.

DTIC Science & Technology

1985-12-01

store images and the microcomputer is used as an interactive and management tool , makes for a powerful teaching system. General Motors was the first...videodisc are used for archival storage of documents. * IBM uses videodisc in over 180 branch offices where they are used both as a presentation tool and to...provide reference material. IBM is also currently working on a videodisc project as a direct training tool for mainten- ance of their computers. A

Multitasking Operating Systems for the IBM PC.

ERIC Educational Resources Information Center

Owen, G. Scott

1985-01-01

The ability of a microcomputer to execute several programs at the same time is called "multitasking." The nature and use of one multitasking operating system Concurrent PC-DOS from Digital Research (the developers of the CP/M operating system) are discussed. (JN)

IBM Cloud Computing Powering a Smarter Planet

NASA Astrophysics Data System (ADS)

Zhu, Jinzy; Fang, Xing; Guo, Zhe; Niu, Meng Hua; Cao, Fan; Yue, Shuang; Liu, Qin Yu

With increasing need for intelligent systems supporting the world's businesses, Cloud Computing has emerged as a dominant trend to provide a dynamic infrastructure to make such intelligence possible. The article introduced how to build a smarter planet with cloud computing technology. First, it introduced why we need cloud, and the evolution of cloud technology. Secondly, it analyzed the value of cloud computing and how to apply cloud technology. Finally, it predicted the future of cloud in the smarter planet.

IBM’s PIQUANT in TREC2003

DTIC Science & Technology

2003-01-01

La Bomba ,’’ ( the bomb ) for his explosive skiing style DSA P11 work: La Bomba LQA P12 most successful and popular Italian skier ever DSA P11...Alberto Tomba , Italy LQA P2 lawyer SQA job: champion LQA P6 work: Slalom for Peace LQA P12 born: Italy LQA P2 work: the Bomba LQA P12 some World Cup

OAP- OFFICE AUTOMATION PILOT GRAPHICS DATABASE SYSTEM

NASA Technical Reports Server (NTRS)

Ackerson, T.

1994-01-01

The Office Automation Pilot (OAP) Graphics Database system offers the IBM PC user assistance in producing a wide variety of graphs and charts. OAP uses a convenient database system, called a chartbase, for creating and maintaining data associated with the charts, and twelve different graphics packages are available to the OAP user. Each of the graphics capabilities is accessed in a similar manner. The user chooses creation, revision, or chartbase/slide show maintenance options from an initial menu. The user may then enter or modify data displayed on a graphic chart. The cursor moves through the chart in a "circular" fashion to facilitate data entries and changes. Various "help" functions and on-screen instructions are available to aid the user. The user data is used to generate the graphics portion of the chart. Completed charts may be displayed in monotone or color, printed, plotted, or stored in the chartbase on the IBM PC. Once completed, the charts may be put in a vector format and plotted for color viewgraphs. The twelve graphics capabilities are divided into three groups: Forms, Structured Charts, and Block Diagrams. There are eight Forms available: 1) Bar/Line Charts, 2) Pie Charts, 3) Milestone Charts, 4) Resources Charts, 5) Earned Value Analysis Charts, 6) Progress/Effort Charts, 7) Travel/Training Charts, and 8) Trend Analysis Charts. There are three Structured Charts available: 1) Bullet Charts, 2) Organization Charts, and 3) Work Breakdown Structure (WBS) Charts. The Block Diagram available is an N x N Chart. Each graphics capability supports a chartbase. The OAP graphics database system provides the IBM PC user with an effective means of managing data which is best interpreted as a graphic display. The OAP graphics database system is written in IBM PASCAL 2.0 and assembler for interactive execution on an IBM PC or XT with at least 384K of memory, and a color graphics adapter and monitor. Printed charts require an Epson, IBM, OKIDATA, or HP Laser

The forearc crustal evolution of Izu-Bonin (Ogasawara) region obtained by seismic reflection and refraction surveys

NASA Astrophysics Data System (ADS)

Yamashita, M.; Kodaira, S.; Takahashi, N.; Tatsumi, Y.; Kaneda, Y.

2009-12-01

The Izu-Bonin (Ogasawara)-Mariana (IBM) arc is known to the typical oceanic island arc, and it is the most suitable area to understand the growth process of island arc. By previous seismic survey and deep sea drilling, convex basements are distributed along North-South direction in present forearc region. The convex basements are reported to be formed during Oligocene and Eocene (Taylor, 1992). In IBM forearc region, the middle crust with 6 km/s is recognized by seismic survey using OBSs. In IBM region, four IODP drilling sites are proposed in order to understand comprehensive growth process of arc and continental crust evolution. Two of them are located in forearc region. Japan Agency for Marine-Earth Science and Technology (JAMSTEC) carried out multi-channel seismic reflection survey using 7,800/12,000 cu.in. air gun and 5-6 km streamer with 444/204 ch hydrophones in the IBM region since 2004. We investigate the crustal structure beneath the Izu-Bonin forearc region for contribution of IBM drilling site along five long survey lines, which are across from present volcanic front to forearc basin. Seismic refraction survey is also conducted across forearc region using 84 OBSs every 1 km interval. Shallow crustal structure can be classified four units including basement which compared between previous drilling results and obtained seismic profiles. In IBM forearc region, thick sedimentary basin distribute from east side of volcanic front. Two convex basement peaks are indicated in across profile of forearc region. These peaks are estimated the top of paleoarc (Oligocene and Eocene) by previous ODP drilling. The half graben structure with major displacement is identified from west side of present volcanic front to the top of Oligocene arc. On the other hand, there is no displacement of sediments between the Oligocene arc and Eocene arc. This result shows the same origin of basement between the present volcanic front and Oligocene arc. There is long time difference of

Economic Evaluation of Voice Recognition (VR) for the Clinician’s Desktop at the Naval Hospital Roosevelt Roads

DTIC Science & Technology

1997-09-01

first PC-based, very large vocabulary dictation system with a continuous natural language free flow approach to speech recognition. (This system allows...indicating the likelihood that a particular stored HMM reference model is the best match for the input. This approach is called the Baum-Welch...InfoCentral, and Envoy 1.0; and Lotus Development Corp.’s SmartSuite 3, Approach 3.0, and Organizer. 2. IBM At a press conference in New York in June 1997, IBM

A SLAM II simulation model for analyzing space station mission processing requirements

NASA Technical Reports Server (NTRS)

Linton, D. G.

1985-01-01

Space station mission processing is modeled via the SLAM 2 simulation language on an IBM 4381 mainframe and an IBM PC microcomputer with 620K RAM, two double-sided disk drives and an 8087 coprocessor chip. Using a time phased mission (payload) schedule and parameters associated with the mission, orbiter (space shuttle) and ground facility databases, estimates for ground facility utilization are computed. Simulation output associated with the science and applications database is used to assess alternative mission schedules.

Measurement and Analysis of the Noise Radiated by Low Mach Numbers Centrifugal Blowers

DTIC Science & Technology

1987-11-01

Lang, V Manager of the IBM Poughkeepsie Acoustics Laboratory, for his understanding and support. I would also like to express my gratitude to the IBM...ficl.l. Knowlede p of these quantities provides important information on the relative strength of thL :cro- a dynamic noise sources on the blade... manageability . The model blower design was thus determined by scaling all of the linear dimensions of the reference device by 2.0 and by maintaining • all of

A System Description of the Cocaine Trade

DTIC Science & Technology

1994-01-01

72 C.17. Drug Market Hirarchy Tables (Cells A112 to N155) ............ 74 C.18. Purity Levels (Cells A156 to E71...This report also provides detailed information on how to use the model. The spreadsheets are available for either IBM (DOS) or Apple -based machines upon...red square (IBM) or arrow ( Apple ) in the upper right- hand corner have a note "behind" the cell explaining something about the data in the cell, or if

A survey of the state-of-the-art and focused research in range systems, task 1

NASA Technical Reports Server (NTRS)

Omura, J. K.

1986-01-01

This final report presents the latest research activity in voice compression. We have designed a non-real time simulation system that is implemented around the IBM-PC where the IBM-PC is used as a speech work station for data acquisition and analysis of voice samples. A real-time implementation is also proposed. This real-time Voice Compression Board (VCB) is built around the Texas Instruments TMS-3220. The voice compression algorithm investigated here was described in an earlier report titled, Low Cost Voice Compression for Mobile Digital Radios, by the author. We will assume the reader is familiar with the voice compression algorithm discussed in this report. The VCB compresses speech waveforms at data rates ranging from 4.8 K bps to 16 K bps. This board interfaces to the IBM-PC 8-bit bus, and plugs into a single expansion slot on the mother board.

Gap models and their individual-based relatives in the assessment of the consequences of global change

NASA Astrophysics Data System (ADS)

Shugart, Herman H.; Wang, Bin; Fischer, Rico; Ma, Jianyong; Fang, Jing; Yan, Xiaodong; Huth, Andreas; Armstrong, Amanda H.

2018-03-01

Individual-based models (IBMs) of complex systems emerged in the 1960s and early 1970s, across diverse disciplines from astronomy to zoology. Ecological IBMs arose with seemingly independent origins out of the tradition of understanding the ecosystems dynamics of ecosystems from a ‘bottom-up’ accounting of the interactions of the parts. Individual trees are principal among the parts of forests. Because these models are computationally demanding, they have prospered as the power of digital computers has increased exponentially over the decades following the 1970s. This review will focus on a class of forest IBMs called gap models. Gap models simulate the changes in forests by simulating the birth, growth and death of each individual tree on a small plot of land. The summation of these plots comprise a forest (or set of sample plots on a forested landscape or region). Other, more aggregated forest IBMs have been used in global applications including cohort-based models, ecosystem demography models, etc. Gap models have been used to provide the parameters for these bulk models. Currently, gap models have grown from local-scale to continental-scale and even global-scale applications to assess the potential consequences of climate change on natural forests. Modifications to the models have enabled simulation of disturbances including fire, insect outbreak and harvest. Our objective in this review is to provide the reader with an overview of the history, motivation and applications, including theoretical applications, of these models. In a time of concern over global changes, gap models are essential tools to understand forest responses to climate change, modified disturbance regimes and other change agents. Development of forest surveys to provide the starting points for simulations and better estimates of the behavior of the diversity of tree species in response to the environment are continuing needs for improvement for these and other IBMs.

Marshalling Corporate Resources for Public and K-12 Technical Education Outreach and Engagement

NASA Astrophysics Data System (ADS)

Wynne, James

2011-03-01

In 1988, the Education Task Force of the Business Roundtable recommended that American corporations invest in pre-college education. Prior to that date, corporate investment was targeted at higher education. IBM and other corporations responded by encouraging their employees and their corporate philanthropic organizations to develop programs aimed at enhancing pre-college education. The IBM TJ Watson Research Center initiated a Local Education Outreach program, active for these past 23 years, that marshals the resources of our science-rich institution to enhance STEM education in our local schools. We have broad and deep partnerships between the Research Center and local school districts, including New York City. We have just completed our 19th consecutive year of Family Science Saturdays, which brings 4th and 5th grade children, along with their parents, to our Research Center for hands-on workshops in topics like States of Matter, Polymer Science, Kitchen Chemistry, and Sound and Light. The workshops are staffed by IBM volunteers, assisted by local high school student ``Peer Teachers.'' Since 1990, the IBM Corporation has joined with a coalition of other companies, professional engineering societies, and government agencies to sponsor the annual Engineers Week (EWeek) campaign of technical education outreach, serving as Corporate Chair in 1992, 2001, and 2008. In recent years, we have annually recruited around 5000 IBM volunteers to reach out to more than 200,000 K-12 students in order to increase their awareness and appreciation of technical careers and encourage them to continue their studies of STEM (science, technology, engineering, and mathematics). The speaker, who helped found the APS Forum on Education (FED) and served as FED Councillor for 8 years, will review these and other programs for Public and K-12 Technical Education Outreach and Engagement.

Frequency and circumstances of falls in people with inclusion body myositis: a questionnaire survey to explore falls management and physiotherapy provision.

PubMed

Hiscock, A; Dewar, L; Parton, M; Machado, P; Hanna, M; Ramdharry, G

2014-03-01

To survey the incidence and circumstances of falls for people with inclusion body myositis (IBM) in the UK, and to investigate the provision of physiotherapy and falls management. Postal questionnaire survey. Participants completed questionnaires at home. Ninety-four people diagnosed with IBM were screened against the inclusion criteria. Seventy-two potential participants were sent a questionnaire, and 62 were completed and returned. Invited participants were sent an adapted Falls Event Questionnaire pertaining to falls, perceived causes of falls and the provision of physiotherapy. Questionnaires were returned anonymously. The proportions of respondents who reported a fall or a near fall, along with the frequencies of falls and near falls were calculated. Descriptive data of falls were collected pertaining to location and cause. Data analysis was performed to investigate provision of physiotherapy services. The response rate was 86% [62/72, mean (standard deviation) age 68 (8) years]. Falls were reported by 98% (61/62) of respondents, with 60% (37/62) falling frequently. In this study, age was not found to be an indicator of falls risk or frequency. Twenty-one percent (13/62) of respondents had not seen a physiotherapist in relation to their IBM symptoms, and of those that had, 31% (15/49) had not seen a physiotherapist until more than 12 months after IBM was diagnosed. Only 18% (11/61) of fallers reported that they had received falls management input. Falls are a common occurrence for people with IBM, independent of age and years since symptoms first presented, and are poorly addressed by appropriate physiotherapy management. National falls guidelines are not being followed, and referral rates to physiotherapy need to improve. Copyright © 2013 Chartered Society of Physiotherapy. Published by Elsevier Ltd. All rights reserved.

Relationship between X(5) models and the interacting boson model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barea, Jose; Departamento de Fisica Atomica, Molecular y Nuclear, Facultad de Fisica, Universidad de Sevilla, Apartado 1065, E-41080 Sevilla; Arias, Jose M.

2010-08-15

The connections between the X(5) models [the original X(5) using an infinite square well, X(5)-{beta}{sup 8}, X(5)-{beta}{sup 6}, X(5)-{beta}{sup 4}, and X(5)-{beta}{sup 2}], based on particular solutions of the geometrical Bohr Hamiltonian with harmonic potential in the {gamma} degree of freedom, and the interacting boson model (IBM) are explored. This work is the natural extension of the work presented in Garcia-Ramos and Arias, Phys. Rev. C 77, 054307 (2008) for the E(5) models. For that purpose, a quite general one- and two-body IBM Hamiltonian is used and a numerical fit to the different X(5) model energies is performed; then themore » obtained wave functions are used to calculate B(E2) transition rates. It is shown that within the IBM one can reproduce well the results for energies and B(E2) transition rates obtained with all these X(5) models, although the agreement is not so impressive as for the E(5) models. From the fitted IBM parameters the corresponding energy surface can be extracted and, surprisingly, only the X(5) case corresponds in the moderately large N limit to an energy surface very close to the one expected for a critical point, whereas the rest of models are situated a little further away.« less

A mechanistic Individual-based Model of microbial communities.

PubMed

Jayathilake, Pahala Gedara; Gupta, Prashant; Li, Bowen; Madsen, Curtis; Oyebamiji, Oluwole; González-Cabaleiro, Rebeca; Rushton, Steve; Bridgens, Ben; Swailes, David; Allen, Ben; McGough, A Stephen; Zuliani, Paolo; Ofiteru, Irina Dana; Wilkinson, Darren; Chen, Jinju; Curtis, Tom

2017-01-01

Accurate predictive modelling of the growth of microbial communities requires the credible representation of the interactions of biological, chemical and mechanical processes. However, although biological and chemical processes are represented in a number of Individual-based Models (IbMs) the interaction of growth and mechanics is limited. Conversely, there are mechanically sophisticated IbMs with only elementary biology and chemistry. This study focuses on addressing these limitations by developing a flexible IbM that can robustly combine the biological, chemical and physical processes that dictate the emergent properties of a wide range of bacterial communities. This IbM is developed by creating a microbiological adaptation of the open source Large-scale Atomic/Molecular Massively Parallel Simulator (LAMMPS). This innovation should provide the basis for "bottom up" prediction of the emergent behaviour of entire microbial systems. In the model presented here, bacterial growth, division, decay, mechanical contact among bacterial cells, and adhesion between the bacteria and extracellular polymeric substances are incorporated. In addition, fluid-bacteria interaction is implemented to simulate biofilm deformation and erosion. The model predicts that the surface morphology of biofilms becomes smoother with increased nutrient concentration, which agrees well with previous literature. In addition, the results show that increased shear rate results in smoother and more compact biofilms. The model can also predict shear rate dependent biofilm deformation, erosion, streamer formation and breakup.

A mechanistic Individual-based Model of microbial communities

PubMed Central

Gupta, Prashant; Li, Bowen; Madsen, Curtis; Oyebamiji, Oluwole; González-Cabaleiro, Rebeca; Rushton, Steve; Bridgens, Ben; Swailes, David; Allen, Ben; McGough, A. Stephen; Zuliani, Paolo; Ofiteru, Irina Dana; Wilkinson, Darren; Chen, Jinju; Curtis, Tom

2017-01-01

Accurate predictive modelling of the growth of microbial communities requires the credible representation of the interactions of biological, chemical and mechanical processes. However, although biological and chemical processes are represented in a number of Individual-based Models (IbMs) the interaction of growth and mechanics is limited. Conversely, there are mechanically sophisticated IbMs with only elementary biology and chemistry. This study focuses on addressing these limitations by developing a flexible IbM that can robustly combine the biological, chemical and physical processes that dictate the emergent properties of a wide range of bacterial communities. This IbM is developed by creating a microbiological adaptation of the open source Large-scale Atomic/Molecular Massively Parallel Simulator (LAMMPS). This innovation should provide the basis for “bottom up” prediction of the emergent behaviour of entire microbial systems. In the model presented here, bacterial growth, division, decay, mechanical contact among bacterial cells, and adhesion between the bacteria and extracellular polymeric substances are incorporated. In addition, fluid-bacteria interaction is implemented to simulate biofilm deformation and erosion. The model predicts that the surface morphology of biofilms becomes smoother with increased nutrient concentration, which agrees well with previous literature. In addition, the results show that increased shear rate results in smoother and more compact biofilms. The model can also predict shear rate dependent biofilm deformation, erosion, streamer formation and breakup. PMID:28771505

Deep Ensemble Learning for Monaural Speech Separation

DTIC Science & Technology

2015-02-01

cse.ohio- state.edu). typically predict the ideal binary mask (IBM) or ideal ratio mask ( IRM ). For the IBM [21], a T-F unit is assigned 1, if the signal...dominance. For the IRM [17], a T- F unit is assigned some ratio of target energy and mixture energy. Kim et al. [15] used Gaussian mixture models (GMM...significantly outperforms earlier separation methods. Subsequently, Wang et al. [23] examined a number of training targets and suggested that the IRM should be

Enhanced job control language procedures for the SIMSYS2D two-dimensional water-quality simulation system

USGS Publications Warehouse

Karavitis, G.A.

1984-01-01

The SIMSYS2D two-dimensional water-quality simulation system is a large-scale digital modeling software system used to simulate flow and transport of solutes in freshwater and estuarine environments. Due to the size, processing requirements, and complexity of the system, there is a need to easily move the system and its associated files between computer sites when required. A series of job control language (JCL) procedures was written to allow transferability between IBM and IBM-compatible computers. (USGS)

Validation of the 1/12 degrees Arctic Cap Nowcast/Forecast System (ACNFS)

DTIC Science & Technology

2010-11-04

IBM Power 6 ( Davinci ) at NAVOCEANO with a 2 hr time step for the ice model and a 30 min time step for the ocean model. All model boundaries are...run using 320 processors on the Navy DSRC IBM Power 6 ( Davinci ) at NAVOCEANO. A typical one-day hindcast takes approximately 1.0 wall clock hour...meter. As more observations become available, further studies of ice draft will be used as a validation tool . The IABP program archived 102 Argos

Validation of the 1/12 deg Arctic Cap Nowcast/Forecast System (ACNFS)

DTIC Science & Technology

2010-11-04

IBM Power 6 ( Davinci ) at NAVOCEANO with a 2 hr time step for the ice model and a 30 min time step for the ocean model. All model boundaries are...run using 320 processors on the Navy DSRC IBM Power 6 ( Davinci ) at NAVOCEANO. A typical one-day hindcast takes approximately 1.0 wall clock hour...meter. As more observations become available, further studies of ice draft will be used as a validation tool . The IABP program archived 102 Argos

Interprocess Communication Protocols for Computer Networks

DTIC Science & Technology

1975-12-01

this value without maintaining any state information about itp partner CCP. The receiving CCP returns a SYN giving its own ISN, or can reject...34Packet Arrival and Buffer Statistics in a Packet Switching Node," IBM Research Report RZ 594 {.s;Zni02),. September 1973. [Cochi73] B. J. Cochi...rwid 0. P. Karp, "Protocol for a Computer Netuork," IBM Sustem Journa! 12. 1, 1973, pp. 94-105. [ricKen2ie741 A. fl. McKenzie

Six Month Oral Toxicity Study of WR238605 Succinate in Rats. Volume 1

DTIC Science & Technology

1996-02-02

expressed on the basis of mg base/kg/day. Statistical analyses was performed on an IBM • compatible computer using the commercially available LabCat... iTP (F) tA/G *BUN tTBA(M/F?) Hematology1 NE *RBC(F) iHCT(F) *HGB(F) tMETHGB *PLT(M) i RBC...1 A-2 Part 1: Identity, Purity and Stability of Neat WR238605 Succinate 0bjttaTO IBM ! The objective of this study was to confirm the identity and

Low temperature Grüneisen parameter of cubic ionic crystals

NASA Astrophysics Data System (ADS)

Batana, Alicia; Monard, María C.; Rosario Soriano, María

1987-02-01

Title of program: CAROLINA Catalogue number: AATG Program obtainable from: CPC Program Library, Queen's University of Belfast, N. Ireland (see application form in this issue) Computer: IBM/370, Model 158; Installation: Centro de Tecnología y Ciencia de Sistemas, Universidad de Buenos Aires Operating system: VM/370 Programming language used: FORTRAN High speed storage required: 3 kwords No. of bits in a word: 32 Peripherals used: disk IBM 3340/70 MB No. of lines in combined program and test deck: 447

Evaluation of a Coast Guard Marine Portable Inspection Unit (MPIU).

DTIC Science & Technology

1994-09-01

38 4.4.1 Focus on Details . ................................... 38 4.4.2 System-Based vs . Compartment-Based Software Organization ..... 38 4.4.3...laptop computer (an IBM ThinkPad 300); the other system was based on a larger pen-based computer which could also serve as a laptop (the Compaq...batteries or from an AC power supply. Battery life is up to 3 hrs and the battery can be changed "on the fly" without data loss. 13 The IBM ThinkPad 300

PREVAIL-EPL alpha tool electron optics subsystem

NASA Astrophysics Data System (ADS)

Pfeiffer, Hans C.; Dhaliwal, Rajinder S.; Golladay, Steven D.; Doran, Samuel K.; Gordon, Michael S.; Kendall, Rodney A.; Lieberman, Jon E.; Pinckney, David J.; Quickle, Robert J.; Robinson, Christopher F.; Rockrohr, James D.; Stickel, Werner; Tressler, Eileen V.

2001-08-01

The IBM/Nikon alliance is continuing pursuit of an EPL stepper alpha tool based on the PREVAIL technology. This paper provides a status report of the alliance activity with particular focus on the Electron Optical Subsystem developed at IBM. We have previously reported on design features of the PREVAIL alpha system. The new state-of-the-art e-beam lithography concepts have since been reduced to practice and turned into functional building blocks of a production level lithography tool. The electron optical alpha tool subsystem has been designed, build, assembled and tested at IBM's Semiconductor Research and Development Center (SRDC) in East Fishkill, New York. After demonstrating subsystem functionality, the electron optical column and all associated control electronics hardware and software have been shipped during January 2001 to Nikon's facility in Kumagaya, Japan, for integration into the Nikon commercial e-beam stepper alpha tool. Early pre-shipment results obtained with this electron optical subsystem are presented.

Specification and preliminary design of an array processor

NASA Technical Reports Server (NTRS)

Slotnick, D. L.; Graham, M. L.

1975-01-01

The design of a computer suited to the class of problems typified by the general circulation of the atmosphere was investigated. A fundamental goal was that the resulting machine should have roughly 100 times the computing capability of an IBM 360/95 computer. A second requirement was that the machine should be programmable in a higher level language similar to FORTRAN. Moreover, the new machine would have to be compatible with the IBM 360/95 since the IBM machine would continue to be used for pre- and post-processing. A third constraint was that the cost of the new machine was to be significantly less than that of other extant machines of similar computing capability, such as the ILLIAC IV and CDC STAR. A final constraint was that it should be feasible to fabricate a complete system and put it in operation by early 1978. Although these objectives were generally met, considerable work remains to be done on the routing system.

Accelerating Climate Simulations Through Hybrid Computing

NASA Technical Reports Server (NTRS)

Zhou, Shujia; Sinno, Scott; Cruz, Carlos; Purcell, Mark

2009-01-01

Unconventional multi-core processors (e.g., IBM Cell B/E and NYIDIDA GPU) have emerged as accelerators in climate simulation. However, climate models typically run on parallel computers with conventional processors (e.g., Intel and AMD) using MPI. Connecting accelerators to this architecture efficiently and easily becomes a critical issue. When using MPI for connection, we identified two challenges: (1) identical MPI implementation is required in both systems, and; (2) existing MPI code must be modified to accommodate the accelerators. In response, we have extended and deployed IBM Dynamic Application Virtualization (DAV) in a hybrid computing prototype system (one blade with two Intel quad-core processors, two IBM QS22 Cell blades, connected with Infiniband), allowing for seamlessly offloading compute-intensive functions to remote, heterogeneous accelerators in a scalable, load-balanced manner. Currently, a climate solar radiation model running with multiple MPI processes has been offloaded to multiple Cell blades with approx.10% network overhead.

Restoration of hemodynamics in apnea struggle phase in association with involuntary breathing movements.

PubMed

Palada, Ivan; Bakovic, Darija; Valic, Zoran; Obad, Ante; Ivancev, Vladimir; Eterovic, Davor; Shoemaker, J Kevin; Dujic, Zeljko

2008-04-30

Involuntary breathing movements (IBM) that occur in the struggle phase of maximal apneas produce waves of negative intrathoracic pressure. This could augment the venous return, increasing thereby the cardiac output and gas exchange, and release the fresh blood from venous pools of spleen and liver. To test these hypotheses we used photoplethysmography and ultrasound for assessment of hemodynamics and spleen size before, during and after maximal dry apneas at large lung volume in 7 trained divers. During the easy-going phase cardiac output was reduced about 40%, due to reduction in stroke volume and in presence of reduced inferior vena cava venous return, while the spleen contracted for about 60 ml. Towards the end of the struggle phase, in presence of intense IBM, the spleen volume further decreased for about 70 ml, while cardiac output and caval flow almost renormalized. In conclusion, IBM coincide with splenic volume reduction and restoration of hemodynamics, likely facilitating the use of the last oxygen reserves before apnea cessation.

ΔI = 4 Bifurcation and the sdg Interacting Boson Model

NASA Astrophysics Data System (ADS)

Liu, Yu-Xin; Sun, Hong-Zhou; Zhao, En-Guang

1997-01-01

We show that the superdeformed nuclear states can be described in the framework of the interacting boson model (IBM) with the g-bosons being taken into account in this paper. The ΔI = 4 bifurcation in superdeformed rotational bands can be reproduced in the SU(5) limit of the sdg IBM. The perturbation causing the ΔI = 4 bifurcation to emerge in the ΔI = 2 superdeformed rotational band may possess the SU(5) symmetry. The project supported by National Natural Science Foundation of China

Management Tools

NASA Technical Reports Server (NTRS)

1987-01-01

Manugistics, Inc. (formerly AVYX, Inc.) has introduced a new programming language for IBM and IBM compatible computers called TREES-pls. It is a resource management tool originating from the space shuttle, that can be used in such applications as scheduling, resource allocation project control, information management, and artificial intelligence. Manugistics, Inc. was looking for a flexible tool that can be applied to many problems with minimal adaptation. Among the non-government markets are aerospace, other manufacturing, transportation, health care, food and beverage and professional services.

Installation of new Generation General Purpose Computer (GPC) compact unit

NASA Technical Reports Server (NTRS)

1991-01-01

In the Kennedy Space Center's (KSC's) Orbiter Processing Facility (OPF) high bay 2, Spacecraft Electronics technician Ed Carter (right), wearing clean suit, prepares for (26864) and installs (26865) the new Generation General Purpose Computer (GPC) compact IBM unit in Atlantis', Orbiter Vehicle (OV) 104's, middeck avionics bay as Orbiter Systems Quality Control technician Doug Snider looks on. Both men work for NASA contractor Lockheed Space Operations Company. All three orbiters are being outfitted with the compact IBM unit, which replaces a two-unit earlier generation computer.

Expert System Enhancement to the Resource Allocation Modules of the NCS Emergency Preparedness Management Information System (EPMIS)

DTIC Science & Technology

1987-01-01

after the MYCIN expert system. Host Computer PC+ is available on both symbolic and numeric computers. It operates on: the IBM PC AT, TI Bus- Pro (IBM PC...suppose that the data baseTool picks up pace contains 100 motors, and in only one case does a lightweight motor pro . duce more power than heavier units...every sor, ART 2.0. In the bargain it con - the figure). decision point takes time. More sub- sumes 10 times less storage. ART 3.0 reduces the comparison

Integrated Aero-Servo-Thermo-Propulso-Elasticity (ASTPE) for Hypersonic Scramjet Vehicle Design/Analysis

DTIC Science & Technology

2009-12-04

heat flux q, see Figure 4.6 - Optimized Weights Winitia, = 0.777 Ibm /ft 2, Wfma! = 0.543 Ibm /ft 2 Shown in Table 4.1 are the optimization results...vehicle: no (0), yes (1), or optimize (2) ideriv - Calculate derivatives: no (0), yes (1) itps - If itps is 1, then prepare for tps and smb. ideriv and... itps cannot be 1 at one time ifeedback - If 1, then gets weight and Cg information from SMB and TPSOPT (1) = height set (1), matrix (2) OUTPUT FILE

The Spatial and Temporal Variability of the Arctic Atmospheric Boundary Layer and Its Effect on Electromagnetic (EM) Propagation.

DTIC Science & Technology

1987-12-01

could be run on the IBM 3033 mainframe at the Naval Postgraduate School. I would also like to thank Lt. Mike Dotson whose thesis provided the...29 pressure levels by using an interactive graphing package, Grafstat, available on the IBM 3033 mainframe at the Naval Postgraduate School. Profiles...Polarstern should probably have been 65 . ¢,- .. ... .. .. -- --- P4. itp so’ W. . Fi.3 5. Cae1 p sbr,1 u,10UC n hpslctosa anh20UC (1) S, 40 m ito ce 2) P, MZ

Operating System For Numerically Controlled Milling Machine

NASA Technical Reports Server (NTRS)

Ray, R. B.

1992-01-01

OPMILL program is operating system for Kearney and Trecker milling machine providing fast easy way to program manufacture of machine parts with IBM-compatible personal computer. Gives machinist "equation plotter" feature, which plots equations that define movements and converts equations to milling-machine-controlling program moving cutter along defined path. System includes tool-manager software handling up to 25 tools and automatically adjusts to account for each tool. Developed on IBM PS/2 computer running DOS 3.3 with 1 MB of random-access memory.

Software Description for the O’Hare Runway Configuration Management System. Volume I. Technical Description,

DTIC Science & Technology

1982-10-01

spent in preparing this document. 00. EXECUTIVE SUMMARY The O’Hare Runway Configuration Management System (CMS) is an interactive multi-user computer ...MITRE Washington’s Computer Center. Currently, CMS is housed in an IBM 4341 computer with VM/SP operating system. CMS employs the IBM’s Display...iV 0O, o 0 .r4L /~ wA 0U 00 00 0 w vi O’Hare, it will operate on a dedicated mini- computer which permits multi-tasking (that is, multiple users

A Western Pacific Hotspot?

NASA Astrophysics Data System (ADS)

MacPherson, C. G.; Hall, R.

2003-04-01

The petrology of volcanic rocks from the St. Andrew Strait and helium isotope ratios of backarc lavas from the Manus Basin have been used to propose the existence of an active hotspot beneath the eastern Bismarck Sea (Johnson et al., 1978; Macpherson et al., 1998). The past influence of this hotspot can be assessed by mapping its present location onto a plate tectonic reconstruction of the western Pacific (Macpherson and Hall, 2001). During the Middle Eocene the nascent Izu-Bonin-Mariana (IBM) arc lay above the hotspot. The volume of magma emplaced at the IBM arc at that time substantially exceeds the average magma production rate for mature island arcs. Furthermore, the ultramafic (boninitic) character of much of this magmatism requires elevated temperatures. The geochemistry of contemporaneous magmatism in the backarc resembles ocean island basalts and much of the backarc region experienced significant uplift at that time. All of these features can be explained by the influx of hot, buoyant, chemically distinct mantle beneath the IBM and its hinterland. The lithosphere lying above the hotspot during the later Eocene was subsequently subducted. During the Oligo-Miocene the hotspot was traversed by parts of the Caroline Plate where the Euripik Rise is found. This is an aseismic rise that possesses the geophysical characteristics of thickened oceanic crust formed by excess, basaltic magmatism and is the type of structure that would result from the passage of relatively young oceanic lithosphere over a mantle hotspot. Plate reconstruction for the western Pacific predicts a hotspot trail that is consistent with the Middle Eocene and Oligo-Miocene geology of the IBM and Caroline Plates, respectively (Macpherson and Hall, 2001). Parts of the trail have been disrupted by subsequent sea-floor spreading or lost through subduction but the remaining vestiges are consistent with the action of a thermal anomaly throughout much of the Cenozoic. More speculatively, buoyancy

Saturn Apollo Program

NASA Image and Video Library

1967-10-01

This is a view of the Saturn V instrument unit (IU) being manufactured in the east high bay at International Business Machines (IBM) in Huntsville, Alabama. IBM is a prime contractor for development and fabrication of the IU. The IU is vital to the proper flight of the vehicle. It contains navigation, guidance, control, and sequencing equipment for the launch vehicle. Three feet tall, twenty-one feet in diameter, and weighing about 4,000 pounds, the IU is mounted atop the S-IVB (third) stage, between the S-IVB stage and the Apollo spacecraft.

Saturn Apollo Program

NASA Image and Video Library

1968-01-01

This view depicts engineers conducting a system test on the Saturn V instrument unit (IU) at International Business Machines (IBM) in Huntsville, Alabama. IBM is a prime contractor for development and fabrication of the IU. The IU is vital to the proper flight of the vehicle. It contains navigation, guidance, control, and sequencing equipment for the launch vehicle. Three-feet tall, twenty-one feet in diameter, and weighing about 4,000 pounds, the IU is mounted atop the S-IVB (third) stage, between the S-IVB stage and the Apollo spacecraft.

Inclusion-Body Myositis Associated with Alzheimer's Disease

PubMed Central

Levacic, Danijela; Peddareddygari, Leema Reddy; Nochlin, David; Sharer, Leroy R.; Grewal, Raji P.

2013-01-01

Sporadic inclusion-body myositis (s-IBM) is a myopathy that is characterized by progressive weakness and muscle pathology demonstrating inflammation and rimmed vacuoles. In addition, similar to the pathology observed in the brains of patients with Alzheimer's disease, the deposition of beta-amyloid and phosphorylated tau proteins in muscle fibers has been reported. These shared pathologic features have prompted hypotheses suggesting a shared etiology of these two conditions. We report a case of a 73-year-old woman initially diagnosed with s-IBM who later developed Alzheimer's disease. PMID:23606855

FASTER 3: A generalized-geometry Monte Carlo computer program for the transport of neutrons and gamma rays. Volume 2: Users manual

NASA Technical Reports Server (NTRS)

Jordan, T. M.

1970-01-01

A description of the FASTER-III program for Monte Carlo Carlo calculation of photon and neutron transport in complex geometries is presented. Major revisions include the capability of calculating minimum weight shield configurations for primary and secondary radiation and optimal importance sampling parameters. The program description includes a users manual describing the preparation of input data cards, the printout from a sample problem including the data card images, definitions of Fortran variables, the program logic, and the control cards required to run on the IBM 7094, IBM 360, UNIVAC 1108 and CDC 6600 computers.

Fourth - generation languages. Volume 2. Representative 4GLs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martin, J.

1986-01-01

The chapters in Part II each describe one representative product marketed by a vendor other than IBM. (Volume III of this work covers IBM languages.) The chapters in Part II cover the following 4GLs: ADS/ONLINE, APPLICATION FACTORY, DATATRIEVE, FOCUS, IDEAL, INTELLECT, MANTIS, MIMER, NATURAL, NOMAD2, RAMIS II, SYSTEM W, and USE-IT. The Perspective section of Part II presents a general overview of the product and describes its role in the marketplace. The Tutorial section describes how a user employs the language in application development.

CET93 and CETPC: An interim updated version of the NASA Lewis computer program for calculating complex chemical equilibria with applications

NASA Technical Reports Server (NTRS)

Mcbride, Bonnie J.; Reno, Martin A.; Gordon, Sanford

1994-01-01

The NASA Lewis chemical equilibrium program with applications continues to be improved and updated. The latest version is CET93. This code, with smaller arrays, has been compiled for use on an IBM or IBM-compatible personal computer and is called CETPC. This report is intended to be primarily a users manual for CET93 and CETPC. It does not repeat the more complete documentation of earlier reports on the equilibrium program. Most of the discussion covers input and output files, two new options (ONLY and comments), example problems, and implementation of CETPC.

Naval Research Logistics Quarterly. Volume 28. Number 2,

DTIC Science & Technology

1981-06-01

Milwaukee Arnoldo Hax, Massachusetts Institute of Technology James G. Taylor, Naval Postgraduate School Alan J. Hoffman, IBM Corporation Harvey M. Wagner...geieral distributiiins /t). If /-I itself i,, if’ phase Itpe with representation (Pr .R f then f14) .1 = exp Ux )4r cxp IRA ) R (A it X ’rI exp l/t) c...23. n = 2 and m = I1, n = 4 in respective CPI times of 23.26 sec and 10.28 sec on IBM 360/65. Kuenne and Soland’s 191 largest reported problem was

Computing Operating Characteristics Of Bearing/Shaft Systems

NASA Technical Reports Server (NTRS)

Moore, James D.

1996-01-01

SHABERTH computer program predicts operating characteristics of bearings in multibearing load-support system. Lubricated and nonlubricated bearings modeled. Calculates loads, torques, temperatures, and fatigue lives of ball and/or roller bearings on single shaft. Provides for analysis of reaction of system to termination of supply of lubricant to bearings and other lubricated mechanical elements. Valuable in design and analysis of shaft/bearing systems. Two versions of SHABERTH available. Cray version (LEW-14860), "Computing Thermal Performances Of Shafts and Bearings". IBM PC version (MFS-28818), written for IBM PC-series and compatible computers running MS-DOS.

GEODYN programmers guide, volume 2, part 1

NASA Technical Reports Server (NTRS)

Mullins, N. E.; Goad, C. C.; Dao, N. C.; Martin, T. V.; Boulware, N. L.; Chin, M. M.

1972-01-01

A guide to the GEODYN Program is presented. The program estimates orbit and geodetic parameters. It possesses the capability to estimate that set of orbital elements, station positions, measurement biases, and a set of force model parameters such that the orbital tracking data from multiple arcs of multiple satellites best fit the entire set of estimated parameters. GEODYN consists of 113 different program segments, including the main program, subroutines, functions, and block data routines. All are in G or H level FORTRAN and are currently operational on GSFC's IBM 360/95 and IBM 360/91.

Crustal Accretion at Subduction Initiation Along Izu-Bonin-Mariana Arc and the Link to SSZ Ophiolites

NASA Astrophysics Data System (ADS)

Ishizuka, O.; Tani, K.; Reagan, M. K.; Kanayama, K.; Umino, S.; Harigane, Y.; Sakamoto, I.

2014-12-01

The Izu-Bonin-Mariana (IBM) forearc preserves the earliest arc magmatic history from subduction initiation to the establishment of the arc. Recent investigations have established a bottom to top igneous stratigraphy of: 1) mantle peridotite, 2) gabbroic rocks, 3) a sheeted dyke complex, 4) basaltic pillow lavas (forearc basalts: FAB), 5) boninites and magnesian andesites, 6) tholeiites and calcalkaline arc lavas. This stratigraphy has many similarities to supra-subduction zone (SSZ) ophiolites. One of the most important common characteristics between the SSZ ophiolites and the forearc crust is the occurrence of MORB-like basaltic lavas underlying or accompanying boninites and early arc volcanic suites. A key observation from the IBM forearc is that FAB differs from nearby back-arc lavas in chemical characteristics, including a depletion in moderately incompatible elements. This indicates that FAB is not a pre-existing oceanic basement of the arc, but the first magmatic product after subduction initiation. Sheeted dikes of FAB composition imply that this magmatism was associated with seafloor spreading, possibly triggered by onset of slab sinking. Recognition of lavas with transitional geochemical characteristics between the FAB and the boninites strongly implies genetic linkage between these two magma types. The close similarity of the igneous stratigraphy of SSZ ophiolites to the IBM forearc section strongly implies a common magmatic evolutionary path, i.e., decompressional melting of a depleted MORB-type mantle is followed by melting of an even more depleted mantle with the addition of slab-derived fluid/melt to produce boninite magma. Similarity of magmatic process between IBM forearc and Tethyan ophiolites appears to be reflected on common characteristics of upper mantle section. Peridotite from both sections show more depleted characteristics compared to upper mantle rocks from mid-ocean ridges. Age determinations reveal that first magmatism at the IBM arc

Chaperone-mediated autophagy components are upregulated in sporadic inclusion-body myositis muscle fibres.

PubMed

Cacciottolo, M; Nogalska, A; D'Agostino, C; Engel, W K; Askanas, V

2013-12-01

Sporadic inclusion-body myositis (s-IBM) is an age-associated degenerative muscle disease. Characteristic features are muscle-fibre vacuolization and intramuscle-fibre accumulations of multiprotein aggregates, which may result from the demonstrated impairments of the 26S proteasome and autophagy. Chaperone-mediated autophagy (CMA) is a selective form of lysosomal degradation targeting proteins carrying the KFERQ motif. Lysosome-associated membrane protein type 2A (LAMP2A) and the heat-shock cognate protein 70 (Hsc70) constitute specific CMA components. Neither CMA components nor CMA activity has been studied in normal or disease human muscle, to our knowledge. We studied CMA components by immunocytochemistry, immunoblots, real-time PCR and immunoprecipitation in: (a) 16 s-IBM, nine aged-matched normal and nine disease control muscle biopsies; and (b) cultured human muscle fibres (CHMFs) with experimentally inhibited activities of either the 26S proteasome or autophagy. Compared with age-matched controls, in s-IBM muscle, LAMP2A and Hsc70 were on a given transverse section accumulated as aggregates in approximately 5% of muscle fibres, where they (a) colocalized with each other and α-synuclein (α-syn), a CMA-targeted protein; and (b) were bound to each other and to α-syn by immunoprecipitation. By immunoblots, LAMP2A was increased sevenfold P < 0.001 and Hsc70 2.6-fold P < 0.05. LAMP2A mRNA was increased 4.4-fold P < 0.001 and Hsc70 mRNA 1.9-fold P < 0.05. In CHMFs inhibition of either the 26S proteasome or autophagy induced CMA, evidenced by a significant increase of both LAMP2A and Hsc70. Our study demonstrates, for the first time, up-regulation of CMA components in s-IBM muscle, and it provides further evidence that altered protein degradation is likely an important pathogenic aspect in s-IBM. © 2013 British Neuropathological Society.

A Fault-Oblivious Extreme-Scale Execution Environment (FOX)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Van Hensbergen, Eric; Speight, William; Xenidis, Jimi

IBM Research’s contribution to the Fault Oblivious Extreme-scale Execution Environment (FOX) revolved around three core research deliverables: • collaboration with Boston University around the Kittyhawk cloud infrastructure which both enabled a development and deployment platform for the project team and provided a fault-injection testbed to evaluate prototypes • operating systems research focused on exploring role-based operating system technologies through collaboration with Sandia National Labs on the NIX research operating system and collaboration with the broader IBM Research community around a hybrid operating system model which became known as FusedOS • IBM Research also participated in an advisory capacity with themore » Boston University SESA project, the core of which was derived from the K42 operating system research project funded in part by DARPA’s HPCS program. Both of these contributions were built on a foundation of previous operating systems research funding by the Department of Energy’s FastOS Program. Through the course of the X-stack funding we were able to develop prototypes, deploy them on production clusters at scale, and make them available to other researchers. As newer hardware, in the form of BlueGene/Q, came online, we were able to port the prototypes to the new hardware and release the source code for the resulting prototypes as open source to the community. In addition to the open source coded for the Kittyhawk and NIX prototypes, we were able to bring the BlueGene/Q Linux patches up to a more recent kernel and contribute them for inclusion by the broader Linux community. The lasting impact of the IBM Research work on FOX can be seen in its effect on the shift of IBM’s approach to HPC operating systems from Linux and Compute Node Kernels to role-based approaches as prototyped by the NIX and FusedOS work. This impact can be seen beyond IBM in follow-on ideas being incorporated into the proposals for the Exasacale

ARC2D - EFFICIENT SOLUTION METHODS FOR THE NAVIER-STOKES EQUATIONS (DEC RISC ULTRIX VERSION)

NASA Technical Reports Server (NTRS)

Biyabani, S. R.

1994-01-01

computers to emulate Cray system time calls, which should be easy to modify for other machines as well. The standard distribution media for this version is a 9-track 1600 BPI ASCII Card Image format magnetic tape. The Cray version was developed in 1987. The IBM ES/3090 version is an IBM port of the Cray version. It is written in IBM VS FORTRAN and has the capability of executing in both vector and parallel modes on the MVS/XA operating system and in vector mode on the VM/XA operating system. Various options of the IBM VS FORTRAN compiler provide new features for the ES/3090 version, including 64-bit arithmetic and up to 2 GB of virtual addressability. The IBM ES/3090 version is available only as a 9-track, 1600 BPI IBM IEBCOPY format magnetic tape. The IBM ES/3090 version was developed in 1989. The DEC RISC ULTRIX version is a DEC port of the Cray version. It is written in FORTRAN 77 for RISC-based Digital Equipment platforms. The memory requirement is approximately 7Mb of main memory. It is available in UNIX tar format on TK50 tape cartridge. The port to DEC RISC ULTRIX was done in 1990. COS and UNICOS are trademarks and Cray is a registered trademark of Cray Research, Inc. IBM, ES/3090, VS FORTRAN, MVS/XA, and VM/XA are registered trademarks of International Business Machines. DEC and ULTRIX are registered trademarks of Digital Equipment Corporation.

ARC2D - EFFICIENT SOLUTION METHODS FOR THE NAVIER-STOKES EQUATIONS (CRAY VERSION)

NASA Technical Reports Server (NTRS)

Pulliam, T. H.

1994-01-01

computers to emulate Cray system time calls, which should be easy to modify for other machines as well. The standard distribution media for this version is a 9-track 1600 BPI ASCII Card Image format magnetic tape. The Cray version was developed in 1987. The IBM ES/3090 version is an IBM port of the Cray version. It is written in IBM VS FORTRAN and has the capability of executing in both vector and parallel modes on the MVS/XA operating system and in vector mode on the VM/XA operating system. Various options of the IBM VS FORTRAN compiler provide new features for the ES/3090 version, including 64-bit arithmetic and up to 2 GB of virtual addressability. The IBM ES/3090 version is available only as a 9-track, 1600 BPI IBM IEBCOPY format magnetic tape. The IBM ES/3090 version was developed in 1989. The DEC RISC ULTRIX version is a DEC port of the Cray version. It is written in FORTRAN 77 for RISC-based Digital Equipment platforms. The memory requirement is approximately 7Mb of main memory. It is available in UNIX tar format on TK50 tape cartridge. The port to DEC RISC ULTRIX was done in 1990. COS and UNICOS are trademarks and Cray is a registered trademark of Cray Research, Inc. IBM, ES/3090, VS FORTRAN, MVS/XA, and VM/XA are registered trademarks of International Business Machines. DEC and ULTRIX are registered trademarks of Digital Equipment Corporation.

Immersed Boundary Methods for High-Resolution Simulation of Atmospheric Boundary-Layer Flow Over Complex Terrain

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lundquist, K A

Mesoscale models, such as the Weather Research and Forecasting (WRF) model, are increasingly used for high resolution simulations, particularly in complex terrain, but errors associated with terrain-following coordinates degrade the accuracy of the solution. Use of an alternative Cartesian gridding technique, known as an immersed boundary method (IBM), alleviates coordinate transformation errors and eliminates restrictions on terrain slope which currently limit mesoscale models to slowly varying terrain. In this dissertation, an immersed boundary method is developed for use in numerical weather prediction. Use of the method facilitates explicit resolution of complex terrain, even urban terrain, in the WRF mesoscale model.more » First, the errors that arise in the WRF model when complex terrain is present are presented. This is accomplished using a scalar advection test case, and comparing the numerical solution to the analytical solution. Results are presented for different orders of advection schemes, grid resolutions and aspect ratios, as well as various degrees of terrain slope. For comparison, results from the same simulation are presented using the IBM. Both two-dimensional and three-dimensional immersed boundary methods are then described, along with details that are specific to the implementation of IBM in the WRF code. Our IBM is capable of imposing both Dirichlet and Neumann boundary conditions. Additionally, a method for coupling atmospheric physics parameterizations at the immersed boundary is presented, making IB methods much more functional in the context of numerical weather prediction models. The two-dimensional IB method is verified through comparisons of solutions for gentle terrain slopes when using IBM and terrain-following grids. The canonical case of flow over a Witch of Agnesi hill provides validation of the basic no-slip and zero gradient boundary conditions. Specified diurnal heating in a valley, producing anabatic winds, is used to

Multiprocessing MCNP on an IBM RS/6000 cluster

DOE Office of Scientific and Technical Information (OSTI.GOV)

McKinney, G.W.; West, J.T.

1993-01-01

The advent of high-performance computer systems has brought to maturity programming concepts like vectorization, multiprocessing, and multitasking. While there are many schools of thought as to the most significant factor in obtaining order-of-magnitude increases in performance, such speedup can only be achieved by integrating the computer system and application code. Vectorization leads to faster manipulation of arrays by overlapping instruction CPU cycles. Discrete ordinates codes, which require the solving of large matrices, have proved to be major benefactors of vectorization. Monte Carlo transport, on the other hand, typically contains numerous logic statements and requires extensive redevelopment to benefit from vectorization.more » Multiprocessing and multitasking provide additional CPU cycles via multiple processors. Such systems are generally designed with either common memory access (multitasking) or distributed memory access. In both cases, theoretical speedup, as a function of the number of processors (P) and the fraction of task time that multiprocesses (f), can be formulated using Amdahl's Law S ((f,P) = 1 f + f/P). However, for most applications this theoretical limit cannot be achieved, due to additional terms not included in Amdahl's Law. Monte Carlo transport is a natural candidate for multiprocessing, since the particle tracks are generally independent and the precision of the result increases as the square root of the number of particles tracked.« less

Multiprocessing MCNP on an IBM RS/6000 cluster

DOE Office of Scientific and Technical Information (OSTI.GOV)

McKinney, G.W.; West, J.T.

1993-03-01

The advent of high-performance computer systems has brought to maturity programming concepts like vectorization, multiprocessing, and multitasking. While there are many schools of thought as to the most significant factor in obtaining order-of-magnitude increases in performance, such speedup can only be achieved by integrating the computer system and application code. Vectorization leads to faster manipulation of arrays by overlapping instruction CPU cycles. Discrete ordinates codes, which require the solving of large matrices, have proved to be major benefactors of vectorization. Monte Carlo transport, on the other hand, typically contains numerous logic statements and requires extensive redevelopment to benefit from vectorization.more » Multiprocessing and multitasking provide additional CPU cycles via multiple processors. Such systems are generally designed with either common memory access (multitasking) or distributed memory access. In both cases, theoretical speedup, as a function of the number of processors (P) and the fraction of task time that multiprocesses (f), can be formulated using Amdahl`s Law S ((f,P) = 1 f + f/P). However, for most applications this theoretical limit cannot be achieved, due to additional terms not included in Amdahl`s Law. Monte Carlo transport is a natural candidate for multiprocessing, since the particle tracks are generally independent and the precision of the result increases as the square root of the number of particles tracked.« less

Mission and data operations IBM 360: User's guide

NASA Technical Reports Server (NTRS)

Balakirsky, J.

1971-01-01

The purpose of this manual is to serve as an introduction to the M&DO computer systems and to supplement all other relevant documentation to be referenced. Because of its index structure, the user will be able to reference those sections pertinent to his needs. This is not a programming manual; where a user needs to learn a language or a system, it will be necessary to review the referenced documents.

Mission and data operations IBM 360 user's guide

NASA Technical Reports Server (NTRS)

Balakirsky, J.

1973-01-01

The M and DO computer systems are introduced and supplemented. The hardware and software status is discussed, along with standard processors and user libraries. Data management techniques are presented, as well as machine independence, debugging facilities, and overlay considerations.

No mutations in hnRNPA1 and hnRNPA2B1 in Dutch patients with amyotrophic lateral sclerosis, frontotemporal dementia, and inclusion body myopathy.

PubMed

Seelen, Meinie; Visser, Anne E; Overste, Daniel J; Kim, Hong J; Palud, A; Wong, Tsz H; van Swieten, John C; Scheltens, Philip; Voermans, Nicol C; Baas, Frank; de Jong, J M B V; van der Kooi, Anneke J; de Visser, Marianne; Veldink, Jan H; Taylor, J Paul; Van Es, Michael A; van den Berg, Leonard H

2014-08-01

Inclusion body myopathy (IBM) associated with Paget disease of the bone, frontotemporal dementia (FTD), and amyotrophic lateral sclerosis (ALS), sometimes called IBMPFD/ALS or multi system proteinopathy, is a rare, autosomal dominant disorder characterized by progressive degeneration of muscle, brain, motor neurons, and bone with prominent TDP-43 pathology. Recently, 2 novel genes for multi system proteinopathy were discovered; heterogenous nuclear ribonucleoprotein (hnRNP) A1 and A2B1. Subsequently, a mutation in hnRNPA1 was also identified in a pedigree with autosomal dominant familial ALS. The genetic evidence for ALS and other neurodegenerative diseases is still insufficient. We therefore sequenced the prion-like domain of these genes in 135 familial ALS, 1084 sporadic ALS, 68 familial FTD, 74 sporadic FTD, and 31 sporadic IBM patients in a Dutch population. We did not identify any mutations in these genes in our cohorts. Mutations in hnRNPA1 and hnRNPA2B1 prove to be a rare cause of ALS, FTD, and IBM in the Netherlands. Copyright © 2014 Elsevier Inc. All rights reserved.

Sodium phenylbutyrate reverses lysosomal dysfunction and decreases amyloid-β42 in an in vitro-model of inclusion-body myositis.

PubMed

Nogalska, Anna; D'Agostino, Carla; Engel, W King; Askanas, Valerie

2014-05-01

Sporadic inclusion-body myositis (s-IBM) is a severe, progressive muscle disease for which there is no enduring treatment. Pathologically characteristic are vacuolated muscle fibers having: accumulations of multi-protein aggregates, including amyloid-β(Aβ) 42 and its toxic oligomers; increased γ-secretase activity; and impaired autophagy. Cultured human muscle fibers with experimentally-impaired autophagy recapitulate some of the s-IBM muscle abnormalities, including vacuolization and decreased activity of lysosomal enzymes, accompanied by increased Aβ42, Aβ42 oligomers, and increased γ-secretase activity. Sodium phenylbutyrate (NaPB) is an orally bioavailable small molecule approved by the FDA for treatment of urea-cycle disorders. Here we describe that NaPB treatment reverses lysosomal dysfunction in an in vitro model of inclusion-body myositis, involving cultured human muscle fibers. NaPB treatment improved lysosomal activity, decreased Aβ42 and its oligomers, decreased γ-secretase activity, and virtually prevented muscle-fiber vacuolization. Accordingly, NaPB might be considered a potential treatment of s-IBM patients. Copyright © 2014 Elsevier Inc. All rights reserved.

Well-Known Distinctive Signatures of Quantum Phase Transition in Shape Coexistence Configuration of Nuclei

NASA Astrophysics Data System (ADS)

Majarshin, A. Jalili; Sabri, H.

2018-06-01

It is interesting that a change of nuclear shape may be described in terms of a phase transition. This paper studies the quantum phase transition of the U(5) to SO(6) in the interacting boson model (IBM) on the finite number N of bosons. This paper explores the well-known distinctive signatures of transition from spherical vibrational to γ-soft shape phase in the IBM with the variation of a control parameter. Quantum phase transitions occur as a result of properties of ground and excited states levels. We apply an affine \\widehat {SU(1,1)} approach to numerically solve non-linear Bethe Ansatz equation and point out what observables are particularly sensitive to the transition. The main aim of this work is to describe the most prominent observables of QPT by using IBM in shape coexistence configuration. We calculate energies of excited states and signatures of QPT as energy surface, energy ratio, energy differences, quadrupole electric transition rates and expectation values of boson number operators and show their behavior in QPT. These observables are calculated and examined for 98 - 102Mo isotopes.

Well-Known Distinctive Signatures of Quantum Phase Transition in Shape Coexistence Configuration of Nuclei

NASA Astrophysics Data System (ADS)

Majarshin, A. Jalili; Sabri, H.

2018-03-01

It is interesting that a change of nuclear shape may be described in terms of a phase transition. This paper studies the quantum phase transition of the U(5) to SO(6) in the interacting boson model (IBM) on the finite number N of bosons. This paper explores the well-known distinctive signatures of transition from spherical vibrational to γ-soft shape phase in the IBM with the variation of a control parameter. Quantum phase transitions occur as a result of properties of ground and excited states levels. We apply an affine \\widehat {SU(1,1)} approach to numerically solve non-linear Bethe Ansatz equation and point out what observables are particularly sensitive to the transition. The main aim of this work is to describe the most prominent observables of QPT by using IBM in shape coexistence configuration. We calculate energies of excited states and signatures of QPT as energy surface, energy ratio, energy differences, quadrupole electric transition rates and expectation values of boson number operators and show their behavior in QPT. These observables are calculated and examined for 98 - 102Mo isotopes.

User's guide: Programs for processing altimeter data over inland seas

NASA Technical Reports Server (NTRS)

Au, A. Y.; Brown, R. D.; Welker, J. E.

1989-01-01

The programs described were developed to process GEODYN-formatted satellite altimeter data, and to apply the processed results to predict geoid undulations and gravity anomalies of inland sea areas. These programs are written in standard FORTRAN 77 and are designed to run on the NSESCC IBM 3081(MVS) computer. Because of the experimental nature of these programs they are tailored to the geographical area analyzed. The attached program listings are customized for processing the altimeter data over the Black Sea. Users interested in the Caspian Sea data are expected to modify each program, although the required modifications are generally minor. Program control parameters are defined in the programs via PARAMETER statements and/or DATA statements. Other auxiliary parameters, such as labels, are hard-wired into the programs. Large data files are read in or written out through different input or output units. The program listings of these programs are accompanied by sample IBM job control language (JCL) images. Familiarity with IBM JCL and the TEMPLATE graphic package is assumed.

An evaluation of Turbo Prolog with an emphasis on its application to the development of expert systems

NASA Technical Reports Server (NTRS)

Loftin, Richard B.

1987-01-01

Turbo Prolog is a recently available, compiled version of the programming language Prolog. Turbo Prolog is designed to provide not only a Prolog compiler, but also a program development environment for the IBM Personal Computer family. An evaluation of Turbo Prolog was made, comparing its features to other versions of Prolog and to the community of languages commonly used in artificial intelligence (AI) research and development. Three programs were employed to determine the execution speed of Turbo Prolog applied to various problems. The results of this evaluation demonstrated that Turbo Prolog can perform much better than many commonly employed AI languages for numerically intensive problems and can equal the speed of development languages such as OPS5+ and CLIPS, running on the IBM PC. Applications for which Turbo Prolog is best suited include those which (1) lend themselves naturally to backward-chaining approaches, (2) require extensive use of mathematics, (3) contain few rules, (4) seek to make use of the window/color graphics capabilities of the IBM PC, and (5) require linkage to programs in other languages to form a complete executable image.

Modeling socio-demography to capture tuberculosis transmission dynamics in a low burden setting

PubMed Central

Ajelli, Marco; Yang, Zhenhua; Merler, Stefano; Furlanello, Cesare; Kirschner, Denise

2011-01-01

Evidence of preferential mixing through selected social routes has been suggested for the transmission of tuberculosis (TB) infection in low burden settings. A realistic modelization of these contact routes is needed to appropriately assess the impact of individually targeted control strategies, such as contact network investigation of index cases and treatment of latent TB infection (LTBI). We propose an age-structured, socio-demographic individual based model (IBM) with a realistic, time-evolving structure of preferential contacts in a population. In particular, transmission within households, schools and work-places, together with a component of casual, distance-dependent contacts are considered. We also compared the model against two other formulations having no social structure of contacts (homogeneous mixing transmission): a baseline deterministic model without age structure and an age-structured IBM. The socio-demographic IBM better fitted recent longitudinal data on TB epidemiology in Arkansas, USA, which serves as an example of a low burden setting. Inclusion of age structure in the model proved fundamental to capturing actual proportions of reactivated TB cases (as opposed to recently transmitted) as well as profiling age-group specific incidence. The socio-demographic structure additionally provides a prediction of TB transmission rates (the rate of infection in household contacts and the rate of secondary cases in household and workplace contacts). These results suggest that the socio-demographic IBM is an optimal choice for evaluating current control strategies, including contact network investigation of index cases, and the simulation of alternative scenarios, particularly for TB eradication targets. PMID:21906603

Identification of Key Beliefs Explaining Male Circumcision Motivation Among Adolescent Boys in Zimbabwe: Targets for Behavior Change Communication.

PubMed

Kasprzyk, Danuta; Tshimanga, Mufuta; Hamilton, Deven T; Gorn, Gerald J; Montaño, Daniel E

2018-02-01

Male circumcision (MC) significantly reduces HIV acquisition among men, leading WHO/UNAIDS to recommend high HIV and low MC prevalence countries circumcise 80% of adolescents and men age 15-49. Despite significant investment to increase MC capacity only 27% of the goal has been achieved in Zimbabwe. To increase adoption, research to create evidence-based messages is greatly needed. The Integrated Behavioral Model (IBM) was used to investigate factors affecting MC motivation among adolescents. Based on qualitative elicitation study results a survey was designed and administered to a representative sample of 802 adolescent boys aged 13-17 in two urban and two rural areas in Zimbabwe. Multiple regression analysis found all six IBM constructs (2 attitude, 2 social influence, 2 personal agency) significantly explained MC intention (R 2  = 0.55). Stepwise regression analysis of beliefs underlying each IBM belief-based construct found 9 behavioral, 6 injunctive norm, 2 descriptive norm, 5 efficacy, and 8 control beliefs significantly explained MC intention. A final stepwise regression of all the significant IBM construct beliefs identified 12 key beliefs best explaining intention. Similar analyses were carried out with subgroups of adolescents by urban-rural and age. Different sets of behavioral, normative, efficacy, and control beliefs were significant for each sub-group. This study demonstrates the application of theory-driven research to identify evidence-based targets for the design of effective MC messages for interventions to increase adolescents' motivation. Incorporating these findings into communication campaigns is likely to improve demand for MC.

ALF: a facility for x-ray lithography II--a progress report

NASA Astrophysics Data System (ADS)

Lesoine, L. G.; Kukkonen, Kenneth W.; Leavey, Jeffrey A.

1992-07-01

In our previous paper which we presented here two years ago, we described the ALF (Advanced Lithography Facility), IBM's new facility for X-ray lithography which was built as an addition to the Advanced Semiconductor Technology Center at IBM's semiconductor plant in Hopewell Jct., NY. At that time, we described the structure, its utilities, facilities and special features such as the radiation shielding, control room, clean room and vibration resistant design. The building has been completed and occupied. By the time this paper is presented the storage ring will be commissioned, the clean room occupied, and two beamlines with one stepper operational. In this paper we will review the successful completion of the facility with its associated hardware. The installation of the synchrotron will be described elsewhere. We will also discuss the first measurements of vibration, clean room cleanliness and the effectiveness of the radiation shielding. The ALF was completed on schedule and cost objectives were met. This is attributed to careful planning, close cooperation among all the parties involved from the technical team in IBM Research, the system vendor (Oxford Instruments of Oxford England) to the many contractors and subcontractors and to strong support from IBM senior management. All the planned building specifications were met and the facility has come on-line with a minimum of problems. Most important, the initial measurements show that the radiation shielding plan is sound and that with a few modifications the dose limit of 10% of background will be met. Any concerns about an electron accelerator and synchrotron in an industrial setting have been eliminated.

The relationship between the clinical features of idiopathic burning mouth syndrome and self-perceived quality of life.

PubMed

Braud, Adeline; Boucher, Yves

2016-01-01

In this descriptive study, we investigated the relationship between the clinical characteristics of idiopathic burning mouth syndrome (iBMS) and the quality of life. Eighteen iBMS patients were interviewed about their experience with pain, oral-associated complaints, cognitive status, and self-perceived quality of life using the French versions of the Hospital Anxiety and Depression Scale (HADS) and the Global Oral Health Assessment Index (GOHAI). The Spearman coefficient was used to analyze correlations. The level of significance was fixed at P < 0.05. The majority of patients described the association of oral burning sensations with other oral complaints, including dry mouth (77.8%), tactile abnormalities (66.7%), thermal abnormalities (44.5%), and taste disturbances (38.9%). HAD-anxiety scores were higher than 10 in 38.8% of iBMS patients and HAD-depression scores were higher than 10 in 33.3% of patients. A significant correlation was found between the number of associated complaints and HAD-depression scores. The mean GOHAI-add score was 37.9 ± 9.6 (mean ± SD), and 94.5% of iBMS patients had a score lower than 50. GOHAI-add scores strongly correlated with pain intensity, which was calculated using a visual analog scale and duration of pain. Our findings indicate a strong correlation between iBMS-related pain and self-perceived oral health-related quality of life. In addition, a correlation was observed between iBMS-associated oral complaints and cognitive status.(J Oral Sci 58, 475-481, 2016).

A Non-Cut Cell Immersed Boundary Method for Use in Icing Simulations

NASA Technical Reports Server (NTRS)

Sarofeen, Christian M.; Noack, Ralph W.; Kreeger, Richard E.

2013-01-01

This paper describes a computational fluid dynamic method used for modelling changes in aircraft geometry due to icing. While an aircraft undergoes icing, the accumulated ice results in a geometric alteration of the aerodynamic surfaces. In computational simulations for icing, it is necessary that the corresponding geometric change is taken into consideration. The method used, herein, for the representation of the geometric change due to icing is a non-cut cell Immersed Boundary Method (IBM). Computational cells that are in a body fitted grid of a clean aerodynamic geometry that are inside a predicted ice formation are identified. An IBM is then used to change these cells from being active computational cells to having properties of viscous solid bodies. This method has been implemented in the NASA developed node centered, finite volume computational fluid dynamics code, FUN3D. The presented capability is tested for two-dimensional airfoils including a clean airfoil, an iced airfoil, and an airfoil in harmonic pitching motion about its quarter chord. For these simulations velocity contours, pressure distributions, coefficients of lift, coefficients of drag, and coefficients of pitching moment about the airfoil's quarter chord are computed and used for comparison against experimental results, a higher order panel method code with viscous effects, XFOIL, and the results from FUN3D's original solution process. The results of the IBM simulations show that the accuracy of the IBM compares satisfactorily with the experimental results, XFOIL results, and the results from FUN3D's original solution process.

Eikonal Scattering in the sdg Interacting Boson Model:. Analytical Results in the SUsdg(3) Limit and Their Generalizations

NASA Astrophysics Data System (ADS)

Kota, V. K. B.

General expression for the representation matrix elements in the SUsdg(3) limit of the sdg interacting boson model (sdgIBM) is derived that determine the scattering amplitude in the eikonal approximation for medium energy proton-nucleus scattering when the target nucleus is deformed and it is described by the SUsdg(3) limit. The SUsdg(3) result is generalized to two important situations: (i) when the target nucleus ground band states are described as states arising out of angular momentum projection from a general single Kπ = 0+ intrinsic state in sdg space; (ii) for rotational bands built on one-phonon excitations in sdgIBM.

IRiS: construction of ARG networks at genomic scales.

PubMed

Javed, Asif; Pybus, Marc; Melé, Marta; Utro, Filippo; Bertranpetit, Jaume; Calafell, Francesc; Parida, Laxmi

2011-09-01

Given a set of extant haplotypes IRiS first detects high confidence recombination events in their shared genealogy. Next using the local sequence topology defined by each detected event, it integrates these recombinations into an ancestral recombination graph. While the current system has been calibrated for human population data, it is easily extendible to other species as well. IRiS (Identification of Recombinations in Sequences) binary files are available for non-commercial use in both Linux and Microsoft Windows, 32 and 64 bit environments from https://researcher.ibm.com/researcher/view_project.php?id = 2303 parida@us.ibm.com.

Watson will see you now: a supercomputer to help clinicians make informed treatment decisions.

PubMed

Doyle-Lindrud, Susan

2015-02-01

IBM has collaborated with several cancer care providers to develop and train the IBM supercomputer Watson to help clinicians make informed treatment decisions. When a patient is seen in clinic, the oncologist can input all of the clinical information into the computer system. Watson will then review all of the data and recommend treatment options based on the latest evidence and guidelines. Once the oncologist makes the treatment decision, this information can be sent directly to the insurance company for approval. Watson has the ability to standardize care and accelerate the approval process, a benefit to the healthcare provider and the patient.

MORPH-I (Ver 1.0) a software package for the analysis of scanning electron micrograph (binary formatted) images for the assessment of the fractal dimension of enclosed pore surfaces

USGS Publications Warehouse

Mossotti, Victor G.; Eldeeb, A. Raouf; Oscarson, Robert

1998-01-01

MORPH-I is a set of C-language computer programs for the IBM PC and compatible minicomputers. The programs in MORPH-I are used for the fractal analysis of scanning electron microscope and electron microprobe images of pore profiles exposed in cross-section. The program isolates and traces the cross-sectional profiles of exposed pores and computes the Richardson fractal dimension for each pore. Other programs in the set provide for image calibration, display, and statistical analysis of the computed dimensions for highly complex porous materials. Requirements: IBM PC or compatible; minimum 640 K RAM; mathcoprocessor; SVGA graphics board providing mode 103 display.

MEGA16 - Computer program for analysis and extrapolation of stress-rupture data

NASA Technical Reports Server (NTRS)

Ensign, C. R.

1981-01-01

The computerized form of the minimum commitment method of interpolating and extrapolating stress versus time to failure data, MEGA16, is described. Examples are given of its many plots and tabular outputs for a typical set of data. The program assumes a specific model equation and then provides a family of predicted isothermals for any set of data with at least 12 stress-rupture results from three different temperatures spread over reasonable stress and time ranges. It is written in FORTRAN 4 using IBM plotting subroutines and its runs on an IBM 370 time sharing system.

A Western Pacific Hotspot?

NASA Astrophysics Data System (ADS)

MacPherson, C. G.; Hall, R.

2002-12-01

The petrology of volcanic rocks from the St. Andrew Strait and helium isotope ratios of backarc lavas from the Manus Basin have been used to propose the existence of an active hotspot beneath the eastern Bismarck Sea [1,2]. The possible influence of this hotspot can be assessed by mapping its present location onto a plate tectonic reconstruction of the western Pacific [3,4]. During the Middle Eocene the nascent Izu-Bonin-Mariana (IBM) arc lay above the hotspot. The volume of magma emplaced at the IBM arc at that time substantially exceeds the average magma production rate for mature island arcs. Furthermore, the ultramafic (boninitic) character of much of this magmatism requires elevated temperatures in the mantle. The geochemistry of contemporaneous magmatism in the backarc resembles melts usually found at ocean islands and much of the backarc region experienced significant uplift at that time. All of these features can be explained by the influx of hot, buoyant, chemically distinct mantle beneath the IBM and its hinterland. The plates lying above the hotspot during the later Eocene were subsequently subducted, but plate reconstruction suggests that during the Oligo-Miocene it was crossed by parts of the Caroline Plate where the Euripik Rise is found. This is an aseismic rise that possesses the geophysical characteristics of thickened oceanic crust formed by excess, basaltic magmatism and is the type of structure that would result from the passage of relatively young oceanic lithosphere over a mantle hotspot. Plate reconstruction for the western Pacific predicts a hotspot trail that is consistent with the Middle Eocene and Oligo-Miocene geology of the IBM and Caroline Plates, respectively. Parts of the trail have been disrupted by subsequent sea-floor spreading or lost through subduction but the remaining vestiges are consistent with the action of a thermal anomaly throughout much of the Cenozoic. More speculatively, the difference in buoyancy between the IBM

Origin of depleted basalts during subduction initiation and early development of the Izu-Bonin-Mariana island arc: Evidence from IODP expedition 351 site U1438, Amami-Sankaku basin

NASA Astrophysics Data System (ADS)

Hickey-Vargas, R.; Yogodzinski, G. M.; Ishizuka, O.; McCarthy, A.; Bizimis, M.; Kusano, Y.; Savov, I. P.; Arculus, R.

2018-05-01

The Izu-Bonin-Mariana (IBM) island arc formed following initiation of subduction of the Pacific plate beneath the Philippine Sea plate at about 52 Ma. Site U1438 of IODP Expedition 351 was drilled to sample the oceanic basement on which the IBM arc was constructed, to better understand magmatism prior to and during the subduction initiation event. Site U1438 igneous basement Unit 1 (150 m) was drilled beneath 1460 m of primarily volcaniclastic sediments and sedimentary rock. Basement basalts are microcrystalline to fine-grained flows and form several distinct subunits (1a-1f), all relatively mafic (MgO = 6.5-13.8%; Mg# = 52-83), with Cr = 71-506 ppm and Ni = 62-342 ppm. All subunits are depleted in non-fluid mobile incompatible trace elements. Ratios such as Sm/Nd (0.35-0.44), Lu/Hf (0.19-0.37), and Zr/Nb (55-106) reach the highest values found in MORB, while La/Yb (0.31-0.92), La/Sm (0.43-0.91) and Nb/La (0.39-0.59) reach the lowest values. Abundances of fluid-mobile incompatible elements, K, Rb, Cs and U, vary with rock physical properties, indicating control by post-eruptive seawater alteration, but lowest abundances are typical of fresh, highly depleted MORBs. Mantle sources for the different subunits define a trend of progressive incompatible element depletion. Inferred pressures of magma segregation are 0.6-2.1 GPa with temperatures of 1280-1470 °C. New 40Ar/39Ar dates for Site U1438 basalts averaging 48.7 Ma (Ishizuka et al., 2018) are younger that the inferred age of IBM subduction initiation based on the oldest ages (52 Ma) of IBM forearc basalts (FAB) from the eastern margin of the Philippine Sea plate. FAB are hypothesized to be the first magma type erupted as the Pacific plate subsided, followed by boninites, and ultimately typical arc magmas over a period of about 10 Ma. Site U1438 basalts and IBM FABs are similar, but Site U1438 basalts have lower V contents, higher Ti/V and little geochemical evidence for involvement of slab-derived fluids. We

Initial magmatism and evolution of the Izu-Bonin-Mariana Arc

NASA Astrophysics Data System (ADS)

Arculus, R. J.

2016-12-01

Expedition 351 of the IODP targeted site U1438 in the Amami Sankaku Basin, northwestern Philippine Sea , 70 km west of the northern Kyushu-Palau Ridge (KPR). The latter formed a chain of stratovolcanoes of the Izu-Bonin-Mariana (IBM) arc, and a remnant arc following migration of the volcanic front eastwards during Shikoku backarc basin formation in the Miocene. Unravelling causes of subduction initiation drove the primary aims of the Expedition involving recovery of igneous basement below the KPR, and a history of the magmatic evolution of the KPR preserved in a clastic record. All these aims were achieved, but with some surprises. Out of 1600m drilled in 4700m water depth, 150m of igneous oceanic crust comprising low-K, tholeiitic basalt lava flows were recovered at U1438. The lavas are variably glassy to microphyric, Cr-spinel-olivine-plagioclase-clinopyroxene-bearing, have high V/Ti, very low absolute rare earth element abundances and low La/Yb, and radiogenic Hf at a given 143/144Nd compared to basalts of mid-ocean ridges. The basement is geochemically and petrologically similar to so-called "forearc basalts" recovered trenchward of the active IBM volcanic front, and of similar or older age (≥52Ma). Highly melt-depleted mantle source(s) were involved and high-temperature, low-pressure dehydration of the subducting Pacific Plate. Compositions of glass (formerly melt) inclusions in clinopyroxene-bearing clasts and sandstones in sediments overlying the basement show a change from medium-Fe (aka "calcalkaline") to low-Fe (tholeiitic) magmas during the Eocene-Oligocene evolution of the KPR. Widespread magmatism along- and across-strike of the nascent IBM system coupled with geologic constraints from the western Philippine Sea, indicate subduction initiation at the IBM arc likely propagated adjacent to Mesozoic-aged arcs/basins to the west of the KPR, following plate reorganization subsequent to the demise of the Izanagi-Pacific Ridge along eastern Asia at 60Ma

S2O - A software tool for integrating research data from general purpose statistic software into electronic data capture systems.

PubMed

Bruland, Philipp; Dugas, Martin

2017-01-07

Data capture for clinical registries or pilot studies is often performed in spreadsheet-based applications like Microsoft Excel or IBM SPSS. Usually, data is transferred into statistic software, such as SAS, R or IBM SPSS Statistics, for analyses afterwards. Spreadsheet-based solutions suffer from several drawbacks: It is generally not possible to ensure a sufficient right and role management; it is not traced who has changed data when and why. Therefore, such systems are not able to comply with regulatory requirements for electronic data capture in clinical trials. In contrast, Electronic Data Capture (EDC) software enables a reliable, secure and auditable collection of data. In this regard, most EDC vendors support the CDISC ODM standard to define, communicate and archive clinical trial meta- and patient data. Advantages of EDC systems are support for multi-user and multicenter clinical trials as well as auditable data. Migration from spreadsheet based data collection to EDC systems is labor-intensive and time-consuming at present. Hence, the objectives of this research work are to develop a mapping model and implement a converter between the IBM SPSS and CDISC ODM standard and to evaluate this approach regarding syntactic and semantic correctness. A mapping model between IBM SPSS and CDISC ODM data structures was developed. SPSS variables and patient values can be mapped and converted into ODM. Statistical and display attributes from SPSS are not corresponding to any ODM elements; study related ODM elements are not available in SPSS. The S2O converting tool was implemented as command-line-tool using the SPSS internal Java plugin. Syntactic and semantic correctness was validated with different ODM tools and reverse transformation from ODM into SPSS format. Clinical data values were also successfully transformed into the ODM structure. Transformation between the spreadsheet format IBM SPSS and the ODM standard for definition and exchange of trial data is feasible

OPMILL - MICRO COMPUTER PROGRAMMING ENVIRONMENT FOR CNC MILLING MACHINES THREE AXIS EQUATION PLOTTING CAPABILITIES

NASA Technical Reports Server (NTRS)

Ray, R. B.

1994-01-01

OPMILL is a computer operating system for a Kearney and Trecker milling machine that provides a fast and easy way to program machine part manufacture with an IBM compatible PC. The program gives the machinist an "equation plotter" feature which plots any set of equations that define axis moves (up to three axes simultaneously) and converts those equations to a machine milling program that will move a cutter along a defined path. Other supported functions include: drill with peck, bolt circle, tap, mill arc, quarter circle, circle, circle 2 pass, frame, frame 2 pass, rotary frame, pocket, loop and repeat, and copy blocks. The system includes a tool manager that can handle up to 25 tools and automatically adjusts tool length for each tool. It will display all tool information and stop the milling machine at the appropriate time. Information for the program is entered via a series of menus and compiled to the Kearney and Trecker format. The program can then be loaded into the milling machine, the tool path graphically displayed, and tool change information or the program in Kearney and Trecker format viewed. The program has a complete file handling utility that allows the user to load the program into memory from the hard disk, save the program to the disk with comments, view directories, merge a program on the disk with one in memory, save a portion of a program in memory, and change directories. OPMILL was developed on an IBM PS/2 running DOS 3.3 with 1 MB of RAM. OPMILL was written for an IBM PC or compatible 8088 or 80286 machine connected via an RS-232 port to a Kearney and Trecker Data Mill 700/C Control milling machine. It requires a "D:" drive (fixed-disk or virtual), a browse or text display utility, and an EGA or better display. Users wishing to modify and recompile the source code will also need Turbo BASIC, Turbo C, and Crescent Software's QuickPak for Turbo BASIC. IBM PC and IBM PS/2 are registered trademarks of International Business Machines. Turbo

Age of Izu-Bonin-Mariana arc basement

NASA Astrophysics Data System (ADS)

Ishizuka, Osamu; Hickey-Vargas, Rosemary; Arculus, Richard J.; Yogodzinski, Gene M.; Savov, Ivan P.; Kusano, Yuki; McCarthy, Anders; Brandl, Philipp A.; Sudo, Masafumi

2018-01-01

Documenting the early tectonic and magmatic evolution of the Izu-Bonin-Mariana (IBM) arc system in the Western Pacific is critical for understanding the process and cause of subduction initiation along the current convergent margin between the Pacific and Philippine Sea plates. Forearc igneous sections provide firm evidence for seafloor spreading at the time of subduction initiation (52 Ma) and production of "forearc basalt". Ocean floor drilling (International Ocean Discovery Program Expedition 351) recovered basement-forming, low-Ti tholeiitic basalt crust formed shortly after subduction initiation but distal from the convergent margin (nominally reararc) of the future IBM arc (Amami Sankaku Basin: ASB). Radiometric dating of this basement gives an age range (49.3-46.8 Ma with a weighted average of 48.7 Ma) that overlaps that of basalt in the present-day IBM forearc, but up to 3.3 m.y. younger than the onset of forearc basalt activity. Similarity in age range and geochemical character between the reararc and forearc basalts implies that the ocean crust newly formed by seafloor spreading during subduction initiation extends from fore- to reararc of the present-day IBM arc. Given the age difference between the oldest forearc basalt and the ASB crust, asymmetric spreading caused by ridge migration might have taken place. This scenario for the formation of the ASB implies that the Mesozoic remnant arc terrane of the Daito Ridges comprised the overriding plate at subduction initiation. The juxtaposition of a relatively buoyant remnant arc terrane adjacent to an oceanic plate was more favourable for subduction initiation than would have been the case if both downgoing and overriding plates had been oceanic.

Evidence-based identification of key beliefs explaining adult male circumcision motivation in Zimbabwe: targets for behavior change messaging.

PubMed

Montaño, Daniel E; Kasprzyk, Danuta; Hamilton, Deven T; Tshimanga, Mufuta; Gorn, Gerald

2014-05-01

Male circumcision (MC) reduces HIV acquisition among men, leading WHO/UNAIDS to recommend a goal to circumcise 80 % of men in high HIV prevalence countries. Significant investment to increase MC capacity in priority countries was made, yet only 5 % of the goal has been achieved in Zimbabwe. The integrated behavioral model (IBM) was used as a framework to investigate the factors affecting MC motivation among men in Zimbabwe. A survey instrument was designed based on elicitation study results, and administered to a representative household-based sample of 1,201 men aged 18-30 from two urban and two rural areas in Zimbabwe. Multiple regression analysis found all five IBM constructs significantly explained MC Intention. Nearly all beliefs underlying the IBM constructs were significantly correlated with MC Intention. Stepwise regression analysis of beliefs underlying each construct respectively found that 13 behavioral beliefs, 5 normative beliefs, 4 descriptive norm beliefs, 6 efficacy beliefs, and 10 control beliefs were significant in explaining MC Intention. A final stepwise regression of the five sets of significant IBM construct beliefs identified 14 key beliefs that best explain Intention. Similar analyses were carried out with subgroups of men by urban-rural and age. Different sets of behavioral, normative, efficacy, and control beliefs were significant for each sub-group, suggesting communication messages need to be targeted to be most effective for sub-groups. Implications for the design of effective MC demand creation messages are discussed. This study demonstrates the application of theory-driven research to identify evidence-based targets for intervention messages to increase men's motivation to get circumcised and thereby improve demand for male circumcision.

The role of p62/SQSTM1 in sporadic inclusion body myositis.

PubMed

Nakano, Satoshi; Oki, Mitsuaki; Kusaka, Hirofumi

2017-04-01

We examined selective autophagy against ubiquitinated protein aggregates in sporadic inclusion body myositis (s-IBM) patients. The form of autophagy requires phosphorylation of serine 403 in p62/SQSTM1 to bind to Lys63-linked ubiquitin and the binding of the p62-ubiquitinated protein conjugates to LC3. In muscle biopsy specimens from 16 s-IBM patients, we compared the distribution of p62 (aa120-440) with 1) Ser403-phosphorylated p62 (S403-pp62), 2) Lys63-linked ubiquitin and 3) LC3 in double-colour immunofluorescence microscopy. S403-pp62, Lys63-linked ubiquitin and LC3 colocalised with p62 aggregates, 79.05% ± 13.64% (mean ± SD), 66.54% ± 19.91% and 51.84% ± 14.1%, respectively. Although positive deposits of S403-pp62 and Lys63-linked ubiquitin were always observed within p62 aggregates, LC3 often showed dissociated distribution from p62. We also found fibres containing small, numerous p62-positive dots that were negative for all three markers and were also observed in myositis controls. The results indicate that p62, Lys63-linked ubiquitin and LC3 in s-IBM join to perform selective autophagy. p62 could be induced by some cellular stresses in all types of myositis; however, in s-IBM, compromised binding of the p62-ubiquitinated protein complex to LC3 could stop the autophagy process in its initial stages, which causes the formation of aggregates of p62-oligomers with Lys63-ubiquitinated proteins. Copyright © 2017 Elsevier B.V. All rights reserved.

Subduction Initiation Existed Along the Ancient Continent Margins? Evidence of U-Pb ages of zircons from the Bonin Trench, Japan

NASA Astrophysics Data System (ADS)

Li, Y. B.; Pearce, J. A.; Ryan, J. G.; Li, X. H.; Haraguchi, S.; Iizuka, T.; Kon, Y.; Yamamoto, S.; Sawaki, Y.; Ishii, T.; Maruyama, S.

2017-12-01

Although it is not cleanly known when and where the subduction initiation began on the Paleo-Izu-Bonin-Mariana (IBM) Trench, Jurassic and Cretaceous plutonic rocks, such as gabbroic, granitic and metamorphic rocks had been sampled from the Amami Plateau-Daito Ridge-Okidaito Ridge (ADO) in the Philippine Sea Plate. Furthermore, Mesozonic to Paleozonic ages zircons were obtained from volcaniclastic sandstones collected from northern Izu-Bonin forarc (Tani et al., 2012). We present U-Pb ages, Hf-O isotopes and trace element compositions of zircon grains separated from sediment, volcanic rock, dolerite and gabbro, collected from Chichijima Island and Bonin forearc seafloor (KH03-3, KT04-28 cruise of the University of Tokyo, IODP Leg 352). In the zircon age histogram, several age groups were identified. The age peaks are 0-3 Ma and 13 Ma (Hahajima Seamount: soft mud and volcanic tuff); 38 Ma (Oomachi Seamount: sandstone); 45 Ma (Chichijima Island: volcanic rock); 40 Ma, 48 Ma and 52 Ma (Hahajima Seamount: dolerite and gabbro); 45 Ma and 164-165 Ma (IODP Leg 352: volcanic rock), respectively. Zircon U-Pb ages ranging 0-52 Ma correspond well to the multi-stages of magmatism in the IBM. However, 164-165 Ma maybe represent the ages of zircon xenocryst including in forearc volcanic rock , which pre-existing in ancient continent crustal materials (SE China Continent Crust?) as the basement of Paleo-IBM. It seems reasonable to suppose that the subduction initiation of IBM existed along the ancient SE China Continent margins. The initiation of subduction zone is a consequence of lateral compositional buoyancy contrast within the lithosphere, that advocated by Niu et al. (2003, 2016).

Engineering graphics data entry for space station data base

NASA Technical Reports Server (NTRS)

Lacovara, R. C.

1986-01-01

The entry of graphical engineering data into the Space Station Data Base was examined. Discussed were: representation of graphics objects; representation of connectivity data; graphics capture hardware; graphics display hardware; site-wide distribution of graphics, and consolidation of tools and hardware. A fundamental assumption was that existing equipment such as IBM based graphics capture software and VAX networked facilities would be exploited. Defensible conclusions reached after study and simulations of use of these systems at the engineering level are: (1) existing IBM based graphics capture software is an adequate and economical means of entry of schematic and block diagram data for present and anticipated electronic systems for Space Station; (2) connectivity data from the aforementioned system may be incorporated into the envisioned Space Station Data Base with modest effort; (3) graphics and connectivity data captured on the IBM based system may be exported to the VAX network in a simple and direct fashion; (4) graphics data may be displayed site-wide on VT-125 terminals and lookalikes; (5) graphics hard-copy may be produced site-wide on various dot-matrix printers; and (6) the system may provide integrated engineering services at both the engineering and engineering management level.

Causes of earthquake spatial distribution beneath the Izu-Bonin-Mariana Arc

NASA Astrophysics Data System (ADS)

Kong, Xiangchao; Li, Sanzhong; Wang, Yongming; Suo, Yanhui; Dai, Liming; Géli, Louis; Zhang, Yong; Guo, Lingli; Wang, Pengcheng

2018-01-01

Statistics about the occurrence frequency of earthquakes (1973-2015) at shallow, intermediate and great depths along the Izu-Bonin-Mariana (IBM) Arc is presented and a percent perturbation relative to P-wave mean value (LLNL-G3Dv3) is adopted to show the deep structure. The correlation coefficient between the subduction rate and the frequency of shallow seismic events along the IBM is 0.605, proving that the subduction rate is an important factor for shallow seismic events. The relationship between relief amplitudes of the seafloor and earthquake occurrences implies that some seamount chains riding on the Pacific seafloor may have an effect on intermediate-depth seismic events along the IBM. A probable hypothesis is proposed that the seamounts or surrounding seafloor with high degree of fracture may bring numerous hydrous minerals into the deep and may result in a different thermal structure compared to the seafloor where no seamounts are subducted. Fluids from the seamounts or surrounding seafloor are released to trigger earthquakes at intermediate-depth. Deep events in the northern and southern Mariana arc are likely affected by a horizontal propagating tear parallel to the trench.

A standard protocol for describing individual-based and agent-based models

USGS Publications Warehouse

Grimm, Volker; Berger, Uta; Bastiansen, Finn; Eliassen, Sigrunn; Ginot, Vincent; Giske, Jarl; Goss-Custard, John; Grand, Tamara; Heinz, Simone K.; Huse, Geir; Huth, Andreas; Jepsen, Jane U.; Jorgensen, Christian; Mooij, Wolf M.; Muller, Birgit; Pe'er, Guy; Piou, Cyril; Railsback, Steven F.; Robbins, Andrew M.; Robbins, Martha M.; Rossmanith, Eva; Ruger, Nadja; Strand, Espen; Souissi, Sami; Stillman, Richard A.; Vabo, Rune; Visser, Ute; DeAngelis, Donald L.

2006-01-01

Simulation models that describe autonomous individual organisms (individual based models, IBM) or agents (agent-based models, ABM) have become a widely used tool, not only in ecology, but also in many other disciplines dealing with complex systems made up of autonomous entities. However, there is no standard protocol for describing such simulation models, which can make them difficult to understand and to duplicate. This paper presents a proposed standard protocol, ODD, for describing IBMs and ABMs, developed and tested by 28 modellers who cover a wide range of fields within ecology. This protocol consists of three blocks (Overview, Design concepts, and Details), which are subdivided into seven elements: Purpose, State variables and scales, Process overview and scheduling, Design concepts, Initialization, Input, and Submodels. We explain which aspects of a model should be described in each element, and we present an example to illustrate the protocol in use. In addition, 19 examples are available in an Online Appendix. We consider ODD as a first step for establishing a more detailed common format of the description of IBMs and ABMs. Once initiated, the protocol will hopefully evolve as it becomes used by a sufficiently large proportion of modellers.

Physiological-based modelling of marine fish early life stages provides process knowledge on climate impacts

NASA Astrophysics Data System (ADS)

Peck, M. A.

2016-02-01

Gaining a cause-and-effect understanding of climate-driven changes in marine fish populations at appropriate spatial scales is important for providing robust advice for ecosystem-based fisheries management. Coupling long-term, retrospective analyses and 3-d biophysical, individual-based models (IBMs) shows great potential to reveal mechanism underlying historical changes and to project future changes in marine fishes. IBMs created for marine fish early life stages integrate organismal-level physiological responses and climate-driven changes in marine habitats (from ocean physics to lower trophic level productivity) to test and reveal processes affecting marine fish recruitment. Case studies are provided for hindcasts and future (A1 and B2 projection) simulations performed on some of the most ecologically- and commercially-important pelagic and demersal fishes in the North Sea including European anchovy, Atlantic herring, European sprat and Atlantic cod. We discuss the utility of coupling biophysical IBMs to size-spectrum models to better project indirect (trophodynamic) pathways of climate influence on the early life stages of these and other fishes. Opportunities and challenges are discussed regarding the ability of these physiological-based tools to capture climate-driven changes in living marine resources and food web dynamics of shelf seas.

Endoplasmic Reticulum Stress Induces Myostatin High Molecular Weight Aggregates and Impairs Mature Myostatin Secretion.

PubMed

Sachdev, Rishibha; Kappes-Horn, Karin; Paulsen, Lydia; Duernberger, Yvonne; Pleschka, Catharina; Denner, Philip; Kundu, Bishwajit; Reimann, Jens; Vorberg, Ina

2018-03-15

Sporadic inclusion body myositis (sIBM) is the most prevalent acquired muscle disorder in the elderly with no defined etiology or effective therapy. Endoplasmic reticulum stress and deposition of myostatin, a secreted negative regulator of muscle growth, have been implicated in disease pathology. The myostatin signaling pathway has emerged as a major target for symptomatic treatment of muscle atrophy. Here, we systematically analyzed the maturation and secretion of myostatin precursor MstnPP and its metabolites in a human muscle cell line. We find that increased MsntPP protein levels induce ER stress. MstnPP metabolites were predominantly retained within the endoplasmic reticulum (ER), also evident in sIBM histology. MstnPP cleavage products formed insoluble high molecular weight aggregates, a process that was aggravated by experimental ER stress. Importantly, ER stress also impaired secretion of mature myostatin. Reduced secretion and aggregation of MstnPP metabolites were not simply caused by overexpression, as both events were also observed in wildtype cells under ER stress. It is tempting to speculate that reduced circulating myostatin growth factor could be one explanation for the poor clinical efficacy of drugs targeting the myostatin pathway in sIBM.

Magnetic sensor technology for detecting mines, UXO, and other concealed security threats

NASA Astrophysics Data System (ADS)

Czipott, Peter V.; Iwanowski, Mark D.

1997-01-01

Magnetic sensors have been the sensor of choice in the detection and classification of buried mines and unexploded ordnance (UXO), both on land and underwater, Quantum Magnetics (QM), together with its research partner IBM, have developed a variety of advanced, very high sensitivity superconducting and room temperature magnetic sensors to meet military needs. This work has led to the development and utilization of a three-sensor gradiometer (TSG) patented by IBM, which cannot only detect, but also localize mines and ordnance. QM is also working with IBM and the U.S. Navy to develop an advanced superconducting gradiometer for buried underwater mine detection. The ability to both detect and classify buried non-metallic mines is virtually impossible with existing magnetic sensors. To solve this problem, Quantum Magnetics, building on work of the Naval Research Laboratory (NRL), is pioneering work in the development of quadrupole resonance (QR) methods which can be used to detect the explosive material directly. Based on recent laboratory work done at QM and previous work done in the U.S., Russia and the United Kingdom, we are confident that QR can be effectively applied to the non-metallic mine identification problem.

Compute Server Performance Results

NASA Technical Reports Server (NTRS)

Stockdale, I. E.; Barton, John; Woodrow, Thomas (Technical Monitor)

1994-01-01

Parallel-vector supercomputers have been the workhorses of high performance computing. As expectations of future computing needs have risen faster than projected vector supercomputer performance, much work has been done investigating the feasibility of using Massively Parallel Processor systems as supercomputers. An even more recent development is the availability of high performance workstations which have the potential, when clustered together, to replace parallel-vector systems. We present a systematic comparison of floating point performance and price-performance for various compute server systems. A suite of highly vectorized programs was run on systems including traditional vector systems such as the Cray C90, and RISC workstations such as the IBM RS/6000 590 and the SGI R8000. The C90 system delivers 460 million floating point operations per second (FLOPS), the highest single processor rate of any vendor. However, if the price-performance ration (PPR) is considered to be most important, then the IBM and SGI processors are superior to the C90 processors. Even without code tuning, the IBM and SGI PPR's of 260 and 220 FLOPS per dollar exceed the C90 PPR of 160 FLOPS per dollar when running our highly vectorized suite,

Program Processes Thermocouple Readings

NASA Technical Reports Server (NTRS)

Quave, Christine A.; Nail, William, III

1995-01-01

Digital Signal Processor for Thermocouples (DART) computer program implements precise and fast method of converting voltage to temperature for large-temperature-range thermocouple applications. Written using LabVIEW software. DART available only as object code for use on Macintosh II FX or higher-series computers running System 7.0 or later and IBM PC-series and compatible computers running Microsoft Windows 3.1. Macintosh version of DART (SSC-00032) requires LabVIEW 2.2.1 or 3.0 for execution. IBM PC version (SSC-00031) requires LabVIEW 3.0 for Windows 3.1. LabVIEW software product of National Instruments and not included with program.

Small Interactive Image Processing System (SMIPS) system description

NASA Technical Reports Server (NTRS)

Moik, J. G.

1973-01-01

The Small Interactive Image Processing System (SMIPS) operates under control of the IBM-OS/MVT operating system and uses an IBM-2250 model 1 display unit as interactive graphic device. The input language in the form of character strings or attentions from keys and light pen is interpreted and causes processing of built-in image processing functions as well as execution of a variable number of application programs kept on a private disk file. A description of design considerations is given and characteristics, structure and logic flow of SMIPS are summarized. Data management and graphic programming techniques used for the interactive manipulation and display of digital pictures are also discussed.

A Computational Architecture for Programmable Automation Research

NASA Astrophysics Data System (ADS)

Taylor, Russell H.; Korein, James U.; Maier, Georg E.; Durfee, Lawrence F.

1987-03-01

This short paper describes recent work at the IBM T. J. Watson Research Center directed at developing a highly flexible computational architecture for research on sensor-based programmable automation. The system described here has been designed with a focus on dynamic configurability, layered user inter-faces and incorporation of sensor-based real time operations into new commands. It is these features which distinguish it from earlier work. The system is cur-rently being implemented at IBM for research purposes and internal use and is an outgrowth of programmable automation research which has been ongoing since 1972 [e.g., 1, 2, 3, 4, 5, 6] .

Effects of Hafnium Additions on the Solidification Behavior of Directionally Solidified Superalloys.

DTIC Science & Technology

1981-10-01

h t (3-1) : where R is the instantaneous rate and h is the transient height. This transient was computed ahead of time on an IBM 370 interactive...form of thermocouple EMF output vs. time, taken at various positions serve as input parameters for the TCTEMP deck for the IBM 370. In its present...iuDv oWIiCNA u 41 S~Q 0 01 0, 0 0 0 % 00 .0 C) 1 0o u- I 0 o0 N 0N Itp 0 0 oitoain3 iuOOJ~d aflOA oian WUOied awnlOA S 1241 - 5 .A - _ A A - S