Sample records for icarus t600 cngs2

  1. Precise 3D Track Reconstruction Algorithm for the ICARUS T600 Liquid Argon Time Projection Chamber Detector

    DOE PAGES

    Antonello, M.; Baibussinov, B.; Benetti, P.; ...

    2013-01-15

    Liquid Argon Time Projection Chamber (LAr TPC) detectors offer charged particle imaging capability with remarkable spatial resolution. Precise event reconstruction procedures are critical in order to fully exploit the potential of this technology. In this paper we present a new, general approach to 3D reconstruction for the LAr TPC with a practical application to the track reconstruction. The efficiency of the method is evaluated on a sample of simulated tracks. We present also the application of the method to the analysis of stopping particle tracks collected during the ICARUS T600 detector operation with the CNGS neutrino beam.

  2. Experimental search for the "LSND anomaly" with the ICARUS detector in the CNGS neutrino beam

    NASA Astrophysics Data System (ADS)

    Antonello, M.; Baibussinov, B.; Benetti, P.; Calligarich, E.; Canci, N.; Centro, S.; Cesana, A.; Cieślik, K.; Cline, D. B.; Cocco, A. G.; Dabrowska, A.; Dequal, D.; Dermenev, A.; Dolfini, R.; Farnese, C.; Fava, A.; Ferrari, A.; Fiorillo, G.; Gibin, D.; Gninenko, S.; Guglielmi, A.; Haranczyk, M.; Holeczek, J.; Ivashkin, A.; Kirsanov, M.; Kisiel, J.; Kochanek, I.; Lagoda, J.; Mania, S.; Menegolli, A.; Meng, G.; Montanari, C.; Otwinowski, S.; Piazzoli, A.; Picchi, P.; Pietropaolo, F.; Plonski, P.; Rappoldi, A.; Raselli, G. L.; Rossella, M.; Rubbia, C.; Sala, P. R.; Scantamburlo, E.; Scaramelli, A.; Segreto, E.; Sergiampietri, F.; Stefan, D.; Stepaniak, J.; Sulej, R.; Szarska, M.; Terrani, M.; Varanini, F.; Ventura, S.; Vignoli, C.; Wang, H. G.; Yang, X.; Zalewska, A.; Zaremba, K.

    2013-03-01

    We report an early result from the ICARUS experiment on the search for a ν μ → ν e signal due to the LSND anomaly. The search was performed with the ICARUS T600 detector located at the Gran Sasso Laboratory, receiving CNGS neutrinos from CERN at an average energy of about 20 GeV, after a flight path of ˜730 km. The LSND anomaly would manifest as an excess of ν e events, characterized by a fast energy oscillation averaging approximately to sin2(1.27Δ m2_{new}L/E_{ν})≈ 1/2 with probability P_{ν_{μ}→ νe} = 1/2 sin2(2θ_{new}). The present analysis is based on 1091 neutrino events, which are about 50 % of the ICARUS data collected in 2010-2011. Two clear ν e events have been found, compared with the expectation of 3.7±0.6 events from conventional sources. Within the range of our observations, this result is compatible with the absence of a LSND anomaly. At 90 % and 99 % confidence levels the limits of 3.4 and 7.3 events corresponding to oscillation probabilities < P_{ν_{μ}→ νe}rangle le 5.4 × 10^{-3} and < P_{ν_{μ}→ νe}rangle le 1.1 × 10^{-2} are set respectively. The result strongly limits the window of open options for the LSND anomaly to a narrow region around (Δ m 2,sin2(2 θ))new=(0.5 eV2,0.005), where there is an overall agreement (90 % CL) between the present ICARUS limit, the published limits of KARMEN and the published positive signals of LSND and MiniBooNE Collaborations.

  3. Search for space charge effects in the ICARUS T600 LAr-TPC

    NASA Astrophysics Data System (ADS)

    Torti, Marta

    2016-11-01

    Space charge in Liquid Argon Time Projection Chamber is due to the accumu- lation of positive ions, produced by ionizing tracks crossing the detector, which slowly flow toward the cathode. As a consequence, electric field distortions may arise, thus hindering the possibility to produce faithful 3D images of the ionizing events. The presence of space charge becomes relevant for large TPCs operating at surface or at shallow depths, where cosmic ray flux is high. These effects could interest the next phase of the ICARUS T600 detector, which will be deployed at shallow depths as a Far Detector for Short Baseline Neutrino experiment at FNAL dedicated to sterile neutrino searches. In 2001, the first ICARUS T600 module (T300) operated at surface in Pavia (Italy), recording cosmic ray data. In this work, a sample of cosmic muon tracks from the 2001 run was analyzed and results on space charge effects in LAr-TPCs are shown.

  4. ICARUS 600 ton: A status report

    NASA Astrophysics Data System (ADS)

    Vignoli, C.; Arneodo, F.; Badertscher, A.; Barbieri, E.; Benetti, P.; di Tigliole, A. Borio; Brunetti, R.; Bueno, A.; Calligarich, E.; Campanelli, M.; Carli, F.; Carpanese, C.; Cavalli, D.; Cavanna, F.; Cennini, P.; Centro, S.; Cesana, A.; Chen, C.; Chen, Y.; Cinquini, C.; Cline, D.; De Mitri, I.; Dolfini, R.; Favaretto, D.; Ferrari, A.; Berzolari, A. Gigli; Goudsmit, P.; He, K.; Huang, X.; Li, Z.; Lu, F.; Ma, J.; Mannocchi, G.; Mauri, F.; Mazza, D.; Mazzone, L.; Montanari, C.; Nurzia, G. P.; Otwinowski, S.; Palamara, O.; Pascoli, D.; Pepato, A.; Periale, L.; Petrera, S.; Piano-Mortari, G.; Piazzoli, A.; Picchi, P.; Pietropaolo, F.; Rancati, T.; Rappoldi, A.; Raselli, G. L.; Rebuzzi, D.; Revol, J. P.; Rico, J.; Rossella, M.; Rossi, C.; Rubbia, A.; Rubbia, C.; Sala, P.; Scannicchio, D.; Sergiampietri, F.; Suzuki, S.; Terrani, M.; Ventura, S.; Verdecchia, M.; Wang, H.; Woo, J.; Xu, G.; Xu, Z.; Zhang, C.; Zhang, Q.; Zheng, S.

    2000-05-01

    The goal of the ICARUS Project is the installation of a multi-kiloton LAr TPC in the underground Gran Sasso Laboratory. The programme foresees the realization of the detector in a modular way. The first step is the construction of a 600 ton module which is now at an advanced phase. It will be mounted and tested in Pavia in one year and then it will be moved to Gran Sasso for the final operation. The major cryogenic and purification systems and the mechanical components of the detector have been constructed and tested in a 10 m 3 prototype. The results of these tests are here summarized.

  5. ICARUS: An Innovative Large LAR Detector for Neutrino Physics

    NASA Astrophysics Data System (ADS)

    Vignoli, C.; Barni, D.; Disdier, J. M.; Rampoldi, D.; Icarus Collaboration

    2006-04-01

    ICARUS is an international project that foresees the installation of very large LAr detectors inside the Gran Sasso underground laboratory in order to be sensitive to rare phenomena of particle physics. The detection technique is based on the collection of electrons produced by particle interactions in LAr by a matrix of thousands of thin wires. At the moment the project foresees the installation of a 600,000-kg vessel (T600). The total amount of LAr can be expanded in a modular way to masses of the order of 106 kg. The T600 houses two identical 300,000-kg Ar sub-cryostats that are aluminum boxes about 20-m long, 4-m high and 4-m wide. Safety requirements for the underground installation have led to a unique design for the vessels to prevent LAr spillages even in the case of inner cryostat failure. Electrons must drift over meters requiring the development of special gas and liquid Ar purification units to provide an extremely high LAr purity (better then 0.1 ppb). The cooling system has been designed to assure a high thermal uniformity in the detector volume (less than 1-K differential). The cryogenic system associated with the final ICARUS configuration is based on three N2 refrigerators, three 30-m3 tanks and pump driven two-phase N2 forced-flow cooling of the various sub-systems. The T600 was successfully tested in Pavia in 2001 and it is now under installation in Gran Sasso for final operation. The future mass expansion strategy is under investigation.

  6. Integrated Cognitive-neuroscience Architectures for Understanding Sensemaking (ICArUS): Phase 2 Challenge Problem Walkthrough

    DTIC Science & Technology

    2014-11-01

    Integrated Cognitive-neuroscience Architectures for Understanding Sensemaking (ICArUS): Phase 2 Challenge Problem Walkthrough Kevin Burns...neuroscience Architectures for Understanding Sensemaking (ICArUS) Phase 2 challenge problem. The pages include screen shots from the tutorial that...Burns, K., Fine, M., Bonaceto, C., & Oertel, C. (2014). Integrated Cognitive-neuroscience Architectures for Understanding Sensemaking (ICArUS

  7. The Myth of Icarus

    NASA Technical Reports Server (NTRS)

    2004-01-01

    Ever since humans first saw birds soar through the sky, they have wanted to fly. The ancient Greeks and Romans pictured many of their gods with winged feet, and imagined mythological winged animals. According to the legend of Daedalus and Icarus, the father and son escaped prison by attaching wings made of wax and feathers to their bodies. Unfortunately, Icarus flew too near the sun, and the heat caused the wax and feathers to melt. The feathers fell off, and Icarus plummeted to the sea. Daedalus landed safely in Sicily.

  8. The Icarus Project: a counter narrative for psychic diversity.

    PubMed

    DuBrul, Sascha Altman

    2014-09-01

    Over the past 12 years, I've had the good fortune of collaborating with others to create a project which challenges and complicates the dominant biopsychiatric model of mental illness. The Icarus Project, founded in 2002, not only critiqued the terms and practices central to the biopsychiatric model, it also inspired a new language and a new community for people struggling with mental health issues in the 21st century. The Icarus Project believes that humans are meaning makers, that meaning is created through developing intrapersonal and interpersonal narratives, and that these narratives are important sites of creativity, struggle, and growth. The Icarus counter narrative and the community it fostered has been invaluable for people around the world dealing with psychic diversity--particularly for people alienated by mainstream approaches. But, despite the numbers of people who have been inspired by this approach, the historical background of the Icarus Project is hard to find. It exists primarily in oral history, newspaper articles, unpublished or self-published Icarus documents, and in internet discussion forums. As the co-founder of the Icarus Project, I use this article to make my understanding of that history and its key documents more widely available.

  9. Project Icarus: Nuclear Fusion Propulsion Concept Comparison

    NASA Astrophysics Data System (ADS)

    Stanic, M.

    Project Icarus will use nuclear fusion as the primary propulsion, since achieving breakeven is imminent within the next decade. Therefore, fusion technology provides confidence in further development and fairly high technological maturity by the time the Icarus mission would be plausible. Currently there are numerous (over 2 dozen) different fusion approaches that are simultaneously being developed around the World and it is difficult to predict which of the concepts is going to be the most successful one. This study tried to estimate current technological maturity and possible technological extrapolation of fusion approaches for which appropriate data could be found. Figures of merit that were assessed include: current technological state, mass and volume estimates, possible gain values, main advantages and disadvantages of the concept and an attempt to extrapolate current technological state for the next decade or two. Analysis suggests that Magnetic Confinement Fusion (MCF) concepts are not likely to deliver sufficient performance due to size, mass, gain and large technological barriers of the concept. However, ICF and PJMIF did show potential for delivering necessary performance, assuming appropriate techno- logical advances. This paper is a submission of the Project Icarus Study Group.

  10. ICARUS Mission, Next Step of Coronal Exploration after Solar Orbiter and Solar Probe Plus

    NASA Astrophysics Data System (ADS)

    Krasnoselskikh, V.; Tsurutani, B.; Velli, M.; Maksimovic, M.; Balikhin, M. A.; Dudok de Wit, T.; Kretzschmar, M.

    2017-12-01

    The primary scientific goal of ICARUS, a mother-daughter satellite mission, will be to determine how the magnetic field and plasma dynamics in the outer solar atmosphere give rise to the corona, the solar wind and the heliosphere. Reaching this goal will be a Rosetta-stone step, with results broadly applicable in the fields of space plasma and astrophysics. Within ESA's Cosmic Vision roadmap, these goals address Theme 2: How does the solar system work ?" Investigating basic processes occurring from the Sun to the edge of the Solar System". ICARUS will not only advance our understanding of the plasma environment around the Sun, but also of the numerous magnetically active stars with hot plasma coronae. ICARUS I will perform the firstever direct in situ measurements of electromagnetic fields, particle acceleration, wave activity, energy distribution and flows directly in the regions where the solar wind emerges from the coronal plasma. ICARUS I will have a perihelion at 1 Solar radius from its surface, it will cross the region where the major energy deposition occurs. The polar orbit of ICARUS I will enable crossing the regions where both the fast and slow wind are generated. It will probe local characteristics of the plasma and provide unique information about the processes involved in the creation of the solar wind. ICARUS II will observe this region using remote-sensing instruments, providing simultaneous information about regions crossed by ICARUS I and the solar atmosphere below as observed by solar telescopes. It will provide bridges for understanding the magnetic links between heliosphere and solar atmosphere. Such information is crucial to understanding of the physics and electrodynamics of the solar atmosphere. ICARUS II will also play an important relay role, enabling the radio-link with ICARUS I. It will receive, collect and store information transmitted from ICARUS I during its closest approach to the Sun. It will perform preliminary data processing and

  11. Developing a weather observation routine during ICARUS

    NASA Astrophysics Data System (ADS)

    Mei, F.; Hubbe, J. M.; de Boer, G.; Lawrence, D.; Shupe, M.; Ivey, M.; Dexheimer, D.; Schmid, B.

    2016-12-01

    Starting in 2014, the Atmospheric Radiation Measurement (ARM) program began a major reconfiguration to more tightly link measurements and atmospheric models. As part of this the reconfiguration, ARM's North Slope of Alaska (NSA) site is being upgraded to include additional observations to support modeling and process studies. The Inaugural Campaigns for ARM Research using Unmanned Systems (ICARUS) have been launched in 2016. This internal initiative at Oliktok Point, Alaska focus on developing routine operations of Unmanned Aerial Systems (UAS) and Tethered Balloon Systems (TBS). The main purpose of ICARUS is to collect spatial data about surface radiation, heat fluxes, and vertical profiles of the basic atmospheric state (temperature, humidity, and horizontal wind). Based on the data collected during ICARUS, we will develop the operation routines for each atmospheric state measurement, and then optimize the operation schedule to maximize the data collection capacity. The statistical representation of important atmospheric state parameters will be discussed.

  12. Icarus: visualizer for de novo assembly evaluation.

    PubMed

    Mikheenko, Alla; Valin, Gleb; Prjibelski, Andrey; Saveliev, Vladislav; Gurevich, Alexey

    2016-11-01

    : Data visualization plays an increasingly important role in NGS data analysis. With advances in both sequencing and computational technologies, it has become a new bottleneck in genomics studies. Indeed, evaluation of de novo genome assemblies is one of the areas that can benefit from the visualization. However, even though multiple quality assessment methods are now available, existing visualization tools are hardly suitable for this purpose. Here, we present Icarus-a novel genome visualizer for accurate assessment and analysis of genomic draft assemblies, which is based on the tool QUAST. Icarus can be used in studies where a related reference genome is available, as well as for non-model organisms. The tool is available online and as a standalone application. http://cab.spbu.ru/software/icarus CONTACT: aleksey.gurevich@spbu.ruSupplementary information: Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  13. ICARUS mission, next step of coronal exploration after Solar Orbiter and Solar Probe Plus

    NASA Astrophysics Data System (ADS)

    Krasnoselskikh, Vladimir; Tsurutani, Bruce T.; Velli, Marco; Maksimovic, Milan; Balikhin, Mikhael; Dudok de Wit, Thierry; Kretzschmar, Matthieu

    2017-04-01

    The primary scientific goal of ICARUS (Investigation of Coronal AcceleRation and heating Up to the Sun), a mother-daughter satellite mission, will be to determine how the magnetic _field and plasma dynamics in the outer solar atmosphere give rise to the corona, the solar wind and the entire heliosphere. Reaching this goal will be a Rosetta-stone step, with results broadly applicable within the fields of space plasma physics and astrophysics. Within ESA's Cosmic Vision roadmap, these science goals address Theme 2: How does the solar system work ?" by investigating basic processes occurring From the Sun to the edge of the Solar System". ICARUS will not only advance our understanding of the plasma environment around our the Sun, but also of the numerous magnetically active stars with hot plasma coronae. ICARUS I will perform the first-ever direct in situ measurements of electromagnetic fields, particle acceleration, wave activity, energy distribution and flows directly in the regions where the solar wind emerges from the coronal plasma. ICARUS I will have a perihelion at 1 Solar radius from its surface, it will cross the region where the major energy deposition occurs. The polar orbit of ICARUS I will enable crossing the regions where both the fast and slow wind are generated. It will probe local characteristics of the plasma and provide unique information about the physical processes involved in the creation of the solar wind. ICARUS II will observe this region using remote-sensing instruments, providing simultaneous information about regions crossed by ICARUS I and the solar atmosphere below as observed by solar telescopes. It will thus provide bridges for understanding the magnetic links between the heliosphere and the solar atmosphere. Such information is crucial to our understanding of the plasma physics and electrodynamics of the solar atmosphere. ICARUS II will also play a very important relay role, enabling the radio-link with ICARUS I. It will receive

  14. Icarus Rewaxed: A high speed, low-cost general aviation aircraft for Aeroworld

    NASA Technical Reports Server (NTRS)

    Farrens, Bryan; Hueckel, Macy; Fulkerson, Dan; Barents, Matt; Capozzi, Brian; Ramsey, Keri

    1994-01-01

    Icarus Rewaxed is a single engine, six passenger, general aviation airplane. With a cruise velocity of 72 ft/s, the Icarus can compete with the performance of any other airplane in its class with an eye on economics and safety. It has a very competitive initial price ($3498.00) and cost per flight ($6.36-8.40). Icarus can serve all airports in Aeroworld with a takeoff distance of 25.4 feet and maximum range of 38,000 feet. It is capable of taking off from an unprepared field with a grass depth of 3 inches. Icarus Rewaxed fills the market need for a high-speed, low cost aircraft. It provides customers with a general aviation craft that can compete in the existing performance market with the added security of an advanced structure. With the use of advanced materials, the maneuvering capability of the Icarus is increased, as it can withstand greater load factors than previous aircraft.

  15. Integrated Cognitive-neuroscience Architectures for Understanding Sensemaking (ICArUS): Phase 1 Challenge Problem Walkthrough

    DTIC Science & Technology

    2014-11-01

    Integrated Cognitive-neuroscience Architectures for Understanding Sensemaking (ICArUS): Phase 1 Challenge Problem Walkthrough Kevin Burns...4. TITLE AND SUBTITLE Integrated Cognitive-neuroscience Architectures for Understanding Sensemaking (ICArUS): Phase 1 Challenge Problem Walkthrough...Integrated Cognitive-neuroscience Architectures for Understanding Sensemaking (ICArUS) Phase 1 challenge problem. The pages include screen shots

  16. Results from the OPERA experiment at the CNGS beam

    NASA Astrophysics Data System (ADS)

    Mauri, N.

    2017-12-01

    The OPERA experiment at the Gran Sasso underground laboratory was designed to study vμ → vτ oscillations in appearance mode in the CNGS neutrino beam. Five vτ candidate events have been observed, allowing to assess the discovery of vμ → vτ transitions in the atmospheric sector with a significance of 5.1σ. In this paper the vτ data analysis will be discussed, with emphasis on the background constraints obtained using dedicated data-driven control samples. Results on the search for vμ → vτ oscillations, on the search for sterile neutrino mixing and on the atmospheric muon charge ratio will also be presented.

  17. Results from the OPERA experiment in the CNGS beam

    NASA Astrophysics Data System (ADS)

    Di Marco, N.; OPERA Collaboration

    2016-05-01

    The OPERA experiment at the Gran Sasso underground laboratory was designed to study ν μ → ν τ oscillations in appearance mode in the CNGS neutrino beam. In this paper we report the detection of the 5 th ν τ candidate event found in the analysis of an enlarged data sample. Given the number of analysed events and the low background, ν μ → ν τ oscillations have been established with a significance of 5.1σ. The analysis of the present electron neutrino sample in the framework of the 3 + 1 sterile model is also presented. Finally the analysis of the muon charge ratio in the cosmic ray sample is discussed.

  18. Project Icarus: Preliminary Thoughts on the Selection of Probes and Instruments for an Icarus-style Interstellar Mission

    NASA Astrophysics Data System (ADS)

    Crawford, Ian A.

    2016-06-01

    In this paper we outline the range of probes and scientific instruments that will be required in order for Icarus to fulfill its scientific mission of exploring a nearby star, its attendant planetary system, and the intervening interstellar medium. Based on this preliminary analysis, we estimate that the minimum total Icarus scientific payload mass (i.e. the mass of probes and instruments which must be decelerated to rest in the target system to enable a meaningful programme of scientific investigation) will be in the region of 100 tonnes. Of this, approximately 10 tonnes would be allocated for cruise-phase science instruments, and about 35 tonnes (i.e. the average of estimated lower and upper limits of 28 and 41 tonnes) would be contributed by the intra-system science payload itself (i.e. the dry mass of the stellar and planetary probes and their instruments). The remaining ~55 tonnes is allocated for the sub-probe intra-system propulsion requirements (crudely estimated from current Solar System missions; detailed modelling of sub-probe propulsion systems will be needed to refine this figure). The overall mass contributed by the science payload to the total that must be decelerated from the interstellar cruise velocity will be considerably more than 100 tonnes, however, as allowance must be made for the payload structural and infrastructural elements required to support, deploy, and communicate with the science probes and instruments. Based on the earlier Daedalus study, we estimate another factor of two to allow for these components. Pending the outcome of more detailed studies, it therefore appears that an overall science-related payload mass of ~200 tonnes will be required. This paper is a submission of the Project Icarus Study Group.

  19. Search for νμ → νe oscillations with the OPERA experiment in the CNGS beam

    NASA Astrophysics Data System (ADS)

    Tenti, M.; OPERA Collaboration

    2016-04-01

    The OPERA hybrid detector, designed to prove neutrino oscillations in the νμ →ντ channel, was exposed to the CNGS νμ beam at a distance of 730 km from the neutrino source. Profiting of the tracking capabilities of its Emulsion Cloud Chamber system, OPERA can perform also a search for νμ →νe oscillations. Current results are compatible with the non-oscillation hypothesis in the three flavour mixing model. The same data allow to constrain the non-standard oscillation parameters θnew and Δmnew2 indicated by the LSND and MiniBooNE experiments.

  20. 16 CFR 600.2 - Legal effect.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Legal effect. 600.2 Section 600.2 Commercial Practices FEDERAL TRADE COMMISSION THE FAIR CREDIT REPORTING ACT STATEMENTS OF GENERAL POLICY OR INTERPRETATIONS § 600.2 Legal effect. (a) The interpretations in the Commentary are not trade regulation rules or...

  1. 16 CFR 600.2 - Legal effect.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Legal effect. 600.2 Section 600.2 Commercial Practices FEDERAL TRADE COMMISSION THE FAIR CREDIT REPORTING ACT STATEMENTS OF GENERAL POLICY OR INTERPRETATIONS § 600.2 Legal effect. (a) The interpretations in the Commentary are not trade regulation rules or...

  2. Integrated Cognitive-neuroscience Architectures for Understanding Sensemaking (ICArUS): Phase 1 Test and Evaluation Development Guide

    DTIC Science & Technology

    2014-11-01

    Integrated Cognitive-neuroscience Architectures for Understanding Sensemaking (ICArUS): Phase 1 Test and Evaluation Development Guide Craig...Self-initiated sensemaking ........................................................................................... 19 Feature Vector Format: Tasks...The Integrated Cognitive-neuroscience Architectures for Understanding Sensemaking (ICArUS) Program aimed to build computational cognitive

  3. Project Icarus: Analysis of Plasma jet driven Magneto-Inertial Fusion as potential primary propulsion driver for the Icarus probe

    NASA Astrophysics Data System (ADS)

    Stanic, M.; Cassibry, J. T.; Adams, R. B.

    2013-05-01

    Hopes of sending probes to another star other than the Sun are currently limited by the maturity of advanced propulsion technologies. One of the few candidate propulsion systems for providing interstellar flight capabilities is nuclear fusion. In the past many fusion propulsion concepts have been proposed and some of them have even been explored in detail, Project Daedalus for example. However, as scientific progress in this field has advanced, new fusion concepts have emerged that merit evaluation as potential drivers for interstellar missions. Plasma jet driven Magneto-Inertial Fusion (PJMIF) is one of those concepts. PJMIF involves a salvo of converging plasma jets that form a uniform liner, which compresses a magnetized target to fusion conditions. It is an Inertial Confinement Fusion (ICF)-Magnetic Confinement Fusion (MCF) hybrid approach that has the potential for a multitude of benefits over both ICF and MCF, such as lower system mass and significantly lower cost. This paper concentrates on a thermodynamic assessment of basic performance parameters necessary for utilization of PJMIF as a candidate propulsion system for the Project Icarus mission. These parameters include: specific impulse, thrust, exhaust velocity, mass of the engine system, mass of the fuel required etc. This is a submission of the Project Icarus Study Group.

  4. Icarus Investigations: A Model for Engaging Citizen Scientists to Solve Solar Big Data Challenges

    NASA Astrophysics Data System (ADS)

    Winter, H. D., III; Loftus, K.

    2017-12-01

    Solar data is growing at an exponential rate. NASA's Atmospheric Imaging Assembly (AIA) has produced a data volume of over 6 petabytes to date, and that volume is growing. The initial suite of instruments on DKIST are expected to generate approximately 25TB of data per day, with bursts up to 50TB. Making sense of this deluge of solar data is as formidable a task as collecting it. New techniques and new ways of thinking are needed in order to optimize the value of this immense amount of data. While machine learning algorithms are a natural tool to sift through Big Data, those tools need to be carefully constructed and trained in order to provide meaningful results. Trained volunteers are needed to provide a large volume of initial classifications in order to properly train machine learning algorithms. To retain a highly trained pool of volunteers to teach machine learning algorithms, we propose to host an ever-changing array of solar-based citizen science projects under a single collaborative project banner: Icarus Investigations. Icarus Investigations would build and retain a dedicated user base within Zooniverse, the most popular citizen science website with over a million registered users. Volunteers will become increasingly comfortable with solar images and solar features of interest as they work on projects that focus on a wide array of solar phenomena. Under a unified framework, new solar citizen science projects submitted to Icarus Investigations will build on the successes, and learn from the missteps, of their predecessors. In this talk we discuss the importance and benefits of engaging the public in citizen science projects and call for collaborators on future citizen science projects. We will also demonstrate the initial Icarus Investigations project, The Where of the Flare. This demonstration will allow us to highlight the workflow of a Icarus Investigations citizen science project with a concrete example.

  5. 21 CFR 600.2 - Mailing addresses.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... BIOLOGICAL PRODUCTS: GENERAL General Provisions § 600.2 Mailing addresses. (a) Licensed biological products... referenced in parts 600 through 680 of this chapter, as applicable, must be sent to: Document Control Center... applications (BLAs) and their amendments and supplements, adverse experience reports, biological product...

  6. 21 CFR 600.2 - Mailing addresses.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... BIOLOGICAL PRODUCTS: GENERAL General Provisions § 600.2 Mailing addresses. (a) Licensed biological products... referenced in parts 600 through 680 of this chapter, as applicable, must be sent to: Document Control Center... applications (BLAs) and their amendments and supplements, adverse experience reports, biological product...

  7. 21 CFR 600.2 - Mailing addresses.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... BIOLOGICAL PRODUCTS: GENERAL General Provisions § 600.2 Mailing addresses. (a) Licensed biological products... referenced in parts 600 through 680 of this chapter, as applicable, must be sent to: Document Control Center... applications (BLAs) and their amendments and supplements, adverse experience reports, biological product...

  8. 75 FR 6862 - Airworthiness Directives; Bombardier, Inc. Model CL-600-1A11 (CL-600), CL-600-2A12 (CL-601), CL...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-12

    ... hydraulic accumulator screw cap or end cap failure have been experienced on CL-600-2B19 (CRJ) aircraft... experienced on CL-600-2B19 (CRJ) aircraft, resulting in loss of the associated hydraulic system and high... on CL-600-2B19 (CRJ) aircraft, resulting in loss of the associated hydraulic system and high-energy...

  9. 75 FR 8461 - Airworthiness Directives; Bombardier, Inc. Model CL-600-1A11 (CL-600), CL-600-2A12 (CL-601), and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-25

    ... Model CL-600-1A11 AFM (Winglets). These two TRs are approved by TCCA, and should be replaced in AD 2009... the Canadair Challenger Model CL-600-1A11 AFM (Winglets). We agreed and proposed to revise Table 2 of...) 600-1/17 August 16, 2006.. Canadair Challenger Model CL-600-1A11 AFM (Winglets). (iii) 601/14 August...

  10. Project Icarus: Stakeholder Scenarios for an Interstellar Exploration Program

    NASA Astrophysics Data System (ADS)

    Hein, A. M.; Tziolas, A. C.; Osborne, R.

    The Project Icarus Study Group's objective is to design a mainly fusion-propelled interstellar probe. The starting point are the results of the Daedalus study, which was conducted by the British Interplanetary Society during the 1970's. As the Daedalus study already indicated, interstellar probes will be the result of a large scale, decade-long development program. To sustain a program over such long periods, the commitment of key stakeholders is vital. Although previous publications identified political and societal preconditions to an interstellar exploration program, there is a lack of more specific scientific and political stakeholder scenarios. This paper develops stakeholder scenarios which allow for a more detailed sustainability assessment of future programs. For this purpose, key stakeholder groups and their needs are identified and scientific and political scenarios derived. Political scenarios are based on patterns of past space programs but unprecedented scenarios are considered as well. Although it is very difficult to sustain an interstellar exploration program, there are scenarios in which this seems to be possible, e.g. the discovery of life within the solar system and on an exoplanet, a global technology development program, and dual-use of technologies for defence and security purposes. This is a submission of the Project Icarus Study Group.

  11. Verification of the Icarus Material Response Tool

    NASA Technical Reports Server (NTRS)

    Schroeder, Olivia; Palmer, Grant; Stern, Eric; Schulz, Joseph; Muppidi, Suman; Martin, Alexandre

    2017-01-01

    Due to the complex physics encountered during reentry, material response solvers are used for two main purposes: improve the understanding of the physical phenomena; and design and size thermal protection systems (TPS). Icarus, is a three dimensional, unstructured material response tool that is intended to be used for design while maintaining the flexibility to easily implement physical models as needed. Because TPS selection and sizing is critical, it is of the utmost importance that the design tools be extensively verified and validated before their use. Verification tests aim at insuring that the numerical schemes and equations are implemented correctly by comparison to analytical solutions and grid convergence tests.

  12. Icarus Institute for Interstellar Sciences (IIS)

    NASA Astrophysics Data System (ADS)

    Cress, B.

    2012-09-01

    In this paper, a vision for a proposed interstellar research center, to be developed in the United States, will be presented. The major focus will be on an innovative approach to the planning and achieving a new sustainable world class facility devoted to the technologies and various science missions of multi-disciplined teams reaching for the stars. The project will provide the personnel, feature sets, facilities and equipment needed to initiate and support an aggressive program of advanced interstellar vehicle and propulsion design and implementation. Also shared will be personal insights and economic considerations gained during prior planning for a private research institute in Nevada, home to more than 300 international scientists. The views expressed in this discussion paper are the personal views of the author and not necessarily representing the entire Icarus team.

  13. 26 CFR 1.6041-1T - Return of information as to payments of $600 or more (temporary).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 13 2014-04-01 2014-04-01 false Return of information as to payments of $600 or more (temporary). 1.6041-1T Section 1.6041-1T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF.... The applicability of this section expires on February 28, 2017. [T.D. 9658, 79 FR 12793, Mar. 6, 2014] ...

  14. Disk Accretion in the 10 Myr Old T Tauri Stars TW Hydrae and Hen 3-600A.

    PubMed

    Muzerolle; Calvet; Briceño; Hartmann; Hillenbrand

    2000-05-20

    We have found that two members of the TW Hydrae association, TW Hydrae and Hen 3-600A, are still actively accreting, based on the ballistic infall signature of their broad Halpha emission profiles. We present the first quantitative analysis of accretion in these objects and conclude that the same accretion mechanisms which operate in the well-studied 1 Myr old T Tauri stars can and do occur in older (10 Myr) stars. We derive the first estimates of the disk mass accretion rate in TW Hya and Hen 3-600A, which are 1-2 orders of magnitude lower than the average rates in 1 Myr old objects. The decrease in accretion rates over 10 Myr, as well as the low fraction of TW Hya association objects still accreting, points to significant disk evolution, possibly linked to planet formation. Given the multiplicity of the Hen 3-600 system and the large UV excess of TW Hya, our results show that accretion disks can be surprisingly long lived in spite of the presence of companions and significant UV ionizing flux.

  15. The Icarus challenge - Predicting vulnerability to climate change using an algorithm-based species' trait approach

    EPA Science Inventory

    The Icarus challenge - Predicting vulnerability to climate change using an algorithm-based species’ trait approachHenry Lee II, Christina Folger, Deborah A. Reusser, Patrick Clinton, and Rene Graham1 U.S. EPA, Western Ecology Division, Newport, OR USA E-mail: lee.henry@ep...

  16. The Icarus challenge - Predicting vulnerability to climate change using an algorithm-based species’ trait approach

    EPA Science Inventory

    Like Icarus, the world’s ecological resources are “flying too close” to the sun, and climate change will impact near-coastal species through temperature, sea-level rise, and ocean acidification and indirectly through changes in invasive species and land-use patt...

  17. Final Results of the OPERA Experiment on ντ Appearance in the CNGS Neutrino Beam

    NASA Astrophysics Data System (ADS)

    Agafonova, N.; Alexandrov, A.; Anokhina, A.; Aoki, S.; Ariga, A.; Ariga, T.; Bertolin, A.; Bozza, C.; Brugnera, R.; Buonaura, A.; Buontempo, S.; Chernyavskiy, M.; Chukanov, A.; Consiglio, L.; D'Ambrosio, N.; de Lellis, G.; de Serio, M.; Del Amo Sanchez, P.; di Crescenzo, A.; di Ferdinando, D.; di Marco, N.; Dmitrievsky, S.; Dracos, M.; Duchesneau, D.; Dusini, S.; Dzhatdoev, T.; Ebert, J.; Ereditato, A.; Favier, J.; Fini, R. A.; Fornari, F.; Fukuda, T.; Galati, G.; Garfagnini, A.; Gentile, V.; Goldberg, J.; Gorbunov, S.; Gornushkin, Y.; Grella, G.; Guler, A. M.; Gustavino, C.; Hagner, C.; Hara, T.; Hayakawa, T.; Hollnagel, A.; Ishiguro, K.; Iuliano, A.; Jakovcic, K.; Jollet, C.; Kamiscioglu, C.; Kamiscioglu, M.; Kim, S. H.; Kitagawa, N.; Klicek, B.; Kodama, K.; Komatsu, M.; Kose, U.; Kreslo, I.; Laudisio, F.; Lauria, A.; Ljubicic, A.; Longhin, A.; Loverre, P.; Malenica, M.; Malgin, A.; Mandrioli, G.; Matsuo, T.; Matveev, V.; Mauri, N.; Medinaceli, E.; Meregaglia, A.; Mikado, S.; Miyanishi, M.; Mizutani, F.; Monacelli, P.; Montesi, M. C.; Morishima, K.; Muciaccia, M. T.; Naganawa, N.; Naka, T.; Nakamura, M.; Nakano, T.; Niwa, K.; Ogawa, S.; Okateva, N.; Olchevsky, A.; Ozaki, K.; Paoloni, A.; Paparella, L.; Park, B. D.; Pasqualini, L.; Pastore, A.; Patrizii, L.; Pessard, H.; Pistillo, C.; Podgrudkov, D.; Polukhina, N.; Pozzato, M.; Pupilli, F.; Roda, M.; Roganova, T.; Rokujo, H.; Rosa, G.; Ryazhskaya, O.; Sadovsky, A.; Sato, O.; Schembri, A.; Shakiryanova, I.; Shchedrina, T.; Shibayama, E.; Shibuya, H.; Shiraishi, T.; Simone, S.; Sirignano, C.; Sirri, G.; Sotnikov, A.; Spinetti, M.; Stanco, L.; Starkov, N.; Stellacci, S. M.; Stipcevic, M.; Strolin, P.; Takahashi, S.; Tenti, M.; Terranova, F.; Tioukov, V.; Tufanli, S.; Ustyuzhanin, A.; Vasina, S.; Vilain, P.; Voevodina, E.; Votano, L.; Vuilleumier, J. L.; Wilquet, G.; Wonsak, B.; Yoon, C. S.; Opera Collaboration

    2018-05-01

    The OPERA experiment was designed to study νμ→ντ oscillations in the appearance mode in the CERN to Gran Sasso Neutrino beam (CNGS). In this Letter, we report the final analysis of the full data sample collected between 2008 and 2012, corresponding to 17.97 ×1019 protons on target. Selection criteria looser than in previous analyses have produced ten ντ candidate events, thus reducing the statistical uncertainty in the measurement of the oscillation parameters and of ντ properties. A multivariate approach for event identification has been applied to the candidate events and the discovery of ντ appearance is confirmed with an improved significance level of 6.1 σ . |Δ m322| has been measured, in appearance mode, with an accuracy of 20%. The measurement of the ντ charged-current cross section, for the first time with a negligible contamination from ν¯τ, and the first direct evidence for the ντ lepton number are also reported.

  18. The GEM-T2 gravitational model

    NASA Technical Reports Server (NTRS)

    Marsh, J. G.; Lerch, F. J.; Putney, B. H.; Felsentreger, T. L.; Sanchez, B. V.; Klosko, S. M.; Patel, G. B.; Robbins, J. W.; Williamson, R. G.; Engelis, T. E.

    1989-01-01

    The GEM-T2 is the latest in a series of Goddard Earth Models of the terrestrial field. It was designed to bring modeling capabilities one step closer towards ultimately determining the TOPEX/Poseidon satellite's radial position to an accuracy of 10-cm RMS (root mean square). It also improves models of the long wavelength geoid to support many oceanographic and geophysical applications. The GEM-T2 extends the spherical harmonic field to include more than 600 coefficients above degree 36 (which was the limit for its predecessor, GEM-T1). Like GEM-T1, it was produced entirely from satellite tracking data, but it now uses nearly twice as many satellites (31 vs. 17), contains four times the number of observations (2.4 million), has twice the number of data arcs (1132), and utilizes precise laser tracking from 11 satellites. The estimation technique for the solution has been augmented to include an optimum data weighting procedure with automatic error calibration for the gravitational parameters. Results for the GEM-T2 error calibration indicate significant improvement over previous satellite-only models. The error of commission in determining the geoid has been reduced from 155 cm in GEM-T1 to 105 cm for GEM-T2 for the 36 x 36 portion of the field, and 141 cm for the entire model. The orbital accuracies achieved using GEM-T2 are likewise improved. Also, the projected radial error on the TOPEX satellite orbit indicates 9.4 cm RMS for GEM-T2, compared to 24.1 cm for GEM-T1.

  19. Developing the Multimedia User Interface Component (MUSIC) for the Icarus Presentation System (IPS)

    DTIC Science & Technology

    1993-12-01

    AD-A276 341 In-House Report December 1993 DEVELOPING THE MULTIMEDIA USER INTERFACE COMPONENT ( MUSIC ) FOR THE ICARUS PRESENTATION SYSTEM (IPS) Ingrid...DATEs COVERED 7 December 1993 Ina-House Jun - Aug 93 4 TWLE AM SL1sM1E & FUNDING NUMBERS DEVELOPING THE MULTIMEDIA USER INTERFACE COMPONENT ( MUSIC ) PE...the Multimedia User Interface Component ( MUSIC ). This report documents the initial research, design and implementation of a prototype of the MUSIC

  20. 40 CFR 721.600 - 3-Alkyl-2-(2-anilino)vinyl thi-azolinium salt (generic name).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false 3-Alkyl-2-(2-anilino)vinyl thi-azolinium salt (generic name). 721.600 Section 721.600 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances § 72...

  1. The BRAF{sup T1799A} mutation confers sensitivity of thyroid cancer cells to the BRAF{sup V600E} inhibitor PLX4032 (RG7204)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Xing, Joanna; Liu, Ruixin; Xing, Mingzhao

    2011-01-28

    Research highlights: {yields} Exciting therapeutic potential has been recently reported for the BRAF{sup V600E} inhibitor PLX4032 in melanoma. {yields} We tested the effects of PLX4032 on the growth of thyroid cancer cells which often harbor the BRAF{sup V600E} mutation. {yields} We observed a potent BRAF{sup V600E}-dependent inhibition of thyroid cancer cells by PLX4032. {yields} We thus demonstrated an important therapeutic potential of PLX4032 for thyroid cancer. -- Abstract: Aberrant signaling of the Ras-Raf-MEK-ERK (MAP kinase) pathway driven by the mutant kinase BRAF{sup V600E}, as a result of the BRAF{sup T1799A} mutation, plays a fundamental role in thyroid tumorigenesis. This studymore » investigated the therapeutic potential of a BRAF{sup V600E}-selective inhibitor, PLX4032 (RG7204), for thyroid cancer by examining its effects on the MAP kinase signaling and proliferation of 10 thyroid cancer cell lines with wild-type BRAF or BRAF{sup T1799A} mutation. We found that PLX4032 could effectively inhibit the MAP kinase signaling, as reflected by the suppression of ERK phosphorylation, in cells harboring the BRAF{sup T1799A} mutation. PLX4032 also showed a potent and BRAF mutation-selective inhibition of cell proliferation in a concentration-dependent manner. PLX4032 displayed low IC{sub 50} values (0.115-1.156 {mu}M) in BRAF{sup V600E} mutant cells, in contrast with wild-type BRAF cells that showed resistance to the inhibitor with high IC{sub 50} values (56.674-1349.788 {mu}M). Interestingly, cells with Ras mutations were also sensitive to PLX4032, albeit moderately. Thus, this study has confirmed that the BRAF{sup T1799A} mutation confers cancer cells sensitivity to PLX4032 and demonstrated its specific potential as an effective and BRAF{sup T1799A} mutation-selective therapeutic agent for thyroid cancer.« less

  2. 2 CFR 180.600 - How do suspension and debarment actions start?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false How do suspension and debarment actions start? 180.600 Section 180.600 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved OMB GUIDELINES TO AGENCIES ON GOVERNMENTWIDE DEBARMENT AND...

  3. The Icarus challenge - Predicting geographical and taxonomic patterns of vulnerability to climate change in near-coastal species

    EPA Science Inventory

    Like Icarus, the world's oceans are "flying too close" to the sun. Increases in temperature and sea level and reductions in pH will affect many, if not most, near-coastal species. The type and severity of the effects will vary both by species and regionally due to geogr...

  4. BRAFV600E Negatively Regulates the AKT Pathway in Melanoma Cell Lines

    PubMed Central

    Chen, Brenden; Tardell, Christine; Higgins, Brian; Packman, Kathryn; Boylan, John F.; Niu, Huifeng

    2012-01-01

    Cross-feedback activation of MAPK and AKT pathways is implicated as a resistance mechanism for cancer therapeutic agents targeting either RAF/MEK or PI3K/AKT/mTOR. It is thus important to have a better understanding of the molecular resistance mechanisms to improve patient survival benefit from these agents. Here we show that BRAFV600E is a negative regulator of the AKT pathway. Expression of BRAFV600E in NIH3T3 cells significantly suppresses MEK inhibitor (RG7167) or mTORC1 inhibitor (rapamycin) induced AKT phosphorylation (pAKT) and downstream signal activation. Treatment-induced pAKT elevation is found in BRAF wild type melanoma cells but not in a subset of melanoma cell lines harboring BRAFV600E. Knock-down of BRAFV600E in these melanoma cells elevates basal pAKT and downstream signals, whereas knock-down of CRAF, MEK1/2 or ERK1/2 or treatment with a BRAF inhibitor have no impact on pAKT. Mechanistically, we show that BRAFV600E interacts with rictor complex (mTORC2) and regulates pAKT through mTORC2. BRAFV600E is identified in mTORC2 after immunoprecipitation of rictor. Knock-down of rictor abrogates BRAFV600E depletion induced pAKT. Knock-down of BRAFV600E enhances cellular enzyme activity of mTORC2. Aberrant activation of AKT pathway by PTEN loss appears to override the negative impact of BRAFV600E on pAKT. Taken together, our findings suggest that in a subset of BRAFV600E melanoma cells, BRAFV600E negatively regulates AKT pathway in a rictor-dependent, MEK/ERK and BRAF kinase-independent manner. Our study reveals a novel molecular mechanism underlying the regulation of feedback loops between the MAPK and AKT pathways. PMID:22880048

  5. BRAFV600E negatively regulates the AKT pathway in melanoma cell lines.

    PubMed

    Chen, Brenden; Tardell, Christine; Higgins, Brian; Packman, Kathryn; Boylan, John F; Niu, Huifeng

    2012-01-01

    Cross-feedback activation of MAPK and AKT pathways is implicated as a resistance mechanism for cancer therapeutic agents targeting either RAF/MEK or PI3K/AKT/mTOR. It is thus important to have a better understanding of the molecular resistance mechanisms to improve patient survival benefit from these agents. Here we show that BRAFV600E is a negative regulator of the AKT pathway. Expression of BRAFV600E in NIH3T3 cells significantly suppresses MEK inhibitor (RG7167) or mTORC1 inhibitor (rapamycin) induced AKT phosphorylation (pAKT) and downstream signal activation. Treatment-induced pAKT elevation is found in BRAF wild type melanoma cells but not in a subset of melanoma cell lines harboring BRAFV600E. Knock-down of BRAFV600E in these melanoma cells elevates basal pAKT and downstream signals, whereas knock-down of CRAF, MEK1/2 or ERK1/2 or treatment with a BRAF inhibitor have no impact on pAKT. Mechanistically, we show that BRAFV600E interacts with rictor complex (mTORC2) and regulates pAKT through mTORC2. BRAFV600E is identified in mTORC2 after immunoprecipitation of rictor. Knock-down of rictor abrogates BRAFV600E depletion induced pAKT. Knock-down of BRAFV600E enhances cellular enzyme activity of mTORC2. Aberrant activation of AKT pathway by PTEN loss appears to override the negative impact of BRAFV600E on pAKT. Taken together, our findings suggest that in a subset of BRAFV600E melanoma cells, BRAFV600E negatively regulates AKT pathway in a rictor-dependent, MEK/ERK and BRAF kinase-independent manner. Our study reveals a novel molecular mechanism underlying the regulation of feedback loops between the MAPK and AKT pathways.

  6. Spectral and laser properties of Er3+/Yb3+/Ce3+ tri-doped Ca3NbGa3Si2O14 crystal at 1.55 µm

    NASA Astrophysics Data System (ADS)

    Gong, Guoliang; Chen, Yujin; Lin, Yanfu; Huang, Jianhua; Gong, Xinghong; Luo, Zundu; Huang, Yidong

    2018-04-01

    An Er3+/Yb3+/Ce3+ tri-doped Ca3NbGa3Si2O14 (CNGS) crystal was grown by the Czochralski method. Spectral properties of the crystal, including the polarized absorption and fluorescence spectra, the fluorescence decay, as well as the energy transfer efficiency from Yb3+ to Er3+ were investigated in detail. End-pumped by a 976 nm diode laser, a 1556 nm continuous-wave laser with a maximum output power of 202 mW and a slope efficiency of 11.4% was achieved in the Er,Yb,Ce:CNGS crystal. The results indicate the Er,Yb,Ce:CNGS crystal is a promising 1.55 µm laser gain medium.

  7. 76 FR 33658 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-09

    ... Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440); Model CL-600-2C10 (Regional Jet Series 700, 701, & 702); Model CL-600-2D15 (Regional Jet Series 705); and Model CL-600-2D24 (Regional Jet Series 900) Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of...

  8. 75 FR 47249 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-05

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010.... Model CL-600-2B19 (Regional Jet Series 100 & 440) Airplanes, CL-600-2C10 (Regional Jet Series 700, 701, & 702) Airplanes, CL-600-2D15 (Regional Jet Series 705) Airplanes, and CL-600-2D24 (Regional Jet Series...

  9. 28 CFR 600.2 - Alternatives available to the Attorney General.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... GENERAL POWERS OF SPECIAL COUNSEL § 600.2 Alternatives available to the Attorney General. When matters are... investigation, consisting of such factual inquiry or legal research as the Attorney General deems appropriate...

  10. Usefulness of immunohistochemistry for the detection of the BRAF V600E mutation in Japanese lung adenocarcinoma.

    PubMed

    Sasaki, Hidefumi; Shimizu, Shigeki; Tani, Yoichi; Shitara, Masayuki; Okuda, Katsuhiro; Hikosaka, Yu; Moriyama, Satoru; Yano, Motoki; Fujii, Yoshitaka

    2013-10-01

    Mutations in components of the mitogen-activated protein kinase (MAPK) cascade may be a new candidate for target for lung cancer. The usefulness of immunohistochemistry (IHC) as a new approach for the detection of BRAF V600E in cancer patients has been recently reported. To increase the sensitivity, we modified BRAF V600E expression detection assay by IHC using mutation specific antibody. From the screening step, we found a novel 599 insertion T BRAF mutation in lung adenocarcinoma. In this study included 26 surgically removed cases with EGFR, Kras, erbB2, EML4-ALK and KIF5B-RET wild-type (wt) lung adenocarcinomas, including 7 BRAF mutants (5 V600E, 1 N581I, and 1 novel 599 insertion T mutation) analyzed by DNA sequencing. Detection of the BRAF V600E mutation was carried out by the Dako EnVision™ FLEX detection system using the VE1 clone antibody and compared with the results of direct sequencing. The autostainer IHC VE1 assay was positive in 5 of 5 (100%) BRAF V600E-mutated tumors and negative in 20 of 21 (95.2%) BRAF non-V600E tumors, except for a novel 599 insertion T case. IHC using the VE1 clone and FLEX linker is a specific method for the detection BRAF V600E and may be an alternative to molecular biology for the detection of mutations in lung adenocarcinomas. This method might be useful for screening to use molecular target therapy for lung adenocarcinomas. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  11. 75 FR 12152 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440), CL...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-15

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010.... Model CL-600-2B19 (Regional Jet Series 100 & 440), CL-600-2C10 (Regional Jet Series 700, 701 & 702), CL-600-2D15 (Regional Jet Series 705), and CL-600-2D24 (Regional Jet Series 900) Airplanes AGENCY...

  12. Motion corrected DWI with integrated T2-mapping for simultaneous estimation of ADC, T2-relaxation and perfusion in prostate cancer.

    PubMed

    Skorpil, M; Brynolfsson, P; Engström, M

    2017-06-01

    Multiparametric magnetic resonance imaging (MRI) and PI-RADS (Prostate Imaging - Reporting and Data System) has become the standard to determine a probability score for a lesion being a clinically significant prostate cancer. T2-weighted and diffusion-weighted imaging (DWI) are essential in PI-RADS, depending partly on visual assessment of signal intensity, while dynamic-contrast enhanced imaging is less important. To decrease inter-rater variability and further standardize image evaluation, complementary objective measures are in need. We here demonstrate a sequence enabling simultaneous quantification of apparent diffusion coefficient (ADC) and T2-relaxation, as well as calculation of the perfusion fraction f from low b-value intravoxel incoherent motion data. Expandable wait pulses were added to a FOCUS DW SE-EPI sequence, allowing the effective echo time to change at run time. To calculate both ADC and f, b-values 200s/mm 2 and 600s/mm 2 were chosen, and for T2-estimation 6 echo times between 64.9ms and 114.9ms were used. Three patients with prostate cancer were examined and all had significantly decreased ADC and T2-values, while f was significantly increased in 2 of 3 tumors. T2 maps obtained in phantom measurements and in a healthy volunteer were compared to T2 maps from a SE sequence with consecutive scans, showing good agreement. In addition, a motion correction procedure was implemented to reduce the effects of prostate motion, which improved T2-estimation. This sequence could potentially enable more objective tumor grading, and decrease the inter-rater variability in the PI-RADS classification. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. 50 CFR 600.750 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Definitions. 600.750 Section 600.750..., DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Fishery Negotiation Panels § 600.750 Definitions... concurrence; or (2) agrees upon another specified definition. Fishery negotiation panel (FNP) means an...

  14. 50 CFR 600.750 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Definitions. 600.750 Section 600.750..., DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Fishery Negotiation Panels § 600.750 Definitions... concurrence; or (2) agrees upon another specified definition. Fishery negotiation panel (FNP) means an...

  15. 9 CFR 592.600 - General.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false General. 592.600 Section 592.600 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION VOLUNTARY INSPECTION OF EGG PRODUCTS Sanitary and Processing Requirements § 592.600 General...

  16. 28 CFR 600.5 - Staff.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Staff. 600.5 Section 600.5 Judicial Administration OFFICES OF INDEPENDENT COUNSEL, DEPARTMENT OF JUSTICE GENERAL POWERS OF SPECIAL COUNSEL § 600.5 Staff. A Special Counsel may request the assignment of appropriate Department employees to assist the...

  17. 28 CFR 600.5 - Staff.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Staff. 600.5 Section 600.5 Judicial Administration OFFICES OF INDEPENDENT COUNSEL, DEPARTMENT OF JUSTICE GENERAL POWERS OF SPECIAL COUNSEL § 600.5 Staff. A Special Counsel may request the assignment of appropriate Department employees to assist the...

  18. 28 CFR 600.5 - Staff.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Staff. 600.5 Section 600.5 Judicial Administration OFFICES OF INDEPENDENT COUNSEL, DEPARTMENT OF JUSTICE GENERAL POWERS OF SPECIAL COUNSEL § 600.5 Staff. A Special Counsel may request the assignment of appropriate Department employees to assist the...

  19. 28 CFR 600.5 - Staff.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Staff. 600.5 Section 600.5 Judicial Administration OFFICES OF INDEPENDENT COUNSEL, DEPARTMENT OF JUSTICE GENERAL POWERS OF SPECIAL COUNSEL § 600.5 Staff. A Special Counsel may request the assignment of appropriate Department employees to assist the...

  20. 28 CFR 600.5 - Staff.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Staff. 600.5 Section 600.5 Judicial Administration OFFICES OF INDEPENDENT COUNSEL, DEPARTMENT OF JUSTICE GENERAL POWERS OF SPECIAL COUNSEL § 600.5 Staff. A Special Counsel may request the assignment of appropriate Department employees to assist the...

  1. Regeneration of long-distance peripheral nerve defects after delayed reconstruction in healthy and diabetic rats is supported by immunomodulatory chitosan nerve guides.

    PubMed

    Stenberg, Lena; Stößel, Maria; Ronchi, Giulia; Geuna, Stefano; Yin, Yaobin; Mommert, Susanne; Mårtensson, Lisa; Metzen, Jennifer; Grothe, Claudia; Dahlin, Lars B; Haastert-Talini, Kirsten

    2017-07-18

    Delayed reconstruction of transection or laceration injuries of peripheral nerves is inflicted by a reduced regeneration capacity. Diabetic conditions, more frequently encountered in clinical practice, are known to further impair regeneration in peripheral nerves. Chitosan nerve guides (CNGs) have recently been introduced as a new generation of medical devices for immediate peripheral nerve reconstruction. Here, CNGs were used for 45 days delayed reconstruction of critical length 15 mm rat sciatic nerve defects in either healthy Wistar rats or diabetic Goto-Kakizaki rats; the latter resembling type 2 diabetes. In short and long-term investigations, we comprehensively analyzed the performance of one-chambered hollow CNGs (hCNGs) and two-chambered CNGs (CFeCNGs) in which a chitosan film has been longitudinally introduced. Additionally, we investigated in vitro the immunomodulatory effect provided by the chitosan film. Both types of nerve guides, i.e. hCNGs and CFeCNGs, enabled moderate morphological and functional nerve regeneration after reconstruction that was delayed for 45 days. These positive findings were detectable in generally healthy as well as in diabetic Goto-Kakizaki rats (for the latter only in short-term studies). The regenerative outcome did not reach the degree as recently demonstrated after immediate reconstruction using hCNGs and CFeCNGs. CFeCNG-treatment, however, enabled tissue regrowth in all animals (hCNGs: only in 80% of animals). CFeCNGs did further support with an increased vascularization of the regenerated tissue and an enhanced regrowth of motor axons. One mechanism by which the CFeCNGs potentially support successful regeneration is an immunomodulatory effect induced by the chitosan film itself. Our in vitro results suggest that the pro-regenerative effect of chitosan is related to the differentiation of chitosan-adherent monocytes into pro-healing M2 macrophages. No considerable differences appear for the delayed nerve regeneration

  2. 9 CFR 592.600 - General.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false General. 592.600 Section 592.600 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION VOLUNTARY INSPECTION OF EGG PRODUCTS Sanitary and Processing Requirements § 592.600 General. Except as otherwise approved by the...

  3. 9 CFR 592.600 - General.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false General. 592.600 Section 592.600 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION VOLUNTARY INSPECTION OF EGG PRODUCTS Sanitary and Processing Requirements § 592.600 General. Except as otherwise approved by the...

  4. 9 CFR 592.600 - General.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false General. 592.600 Section 592.600 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION VOLUNTARY INSPECTION OF EGG PRODUCTS Sanitary and Processing Requirements § 592.600 General. Except as otherwise approved by the...

  5. 9 CFR 592.600 - General.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false General. 592.600 Section 592.600 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION VOLUNTARY INSPECTION OF EGG PRODUCTS Sanitary and Processing Requirements § 592.600 General. Except as otherwise approved by the...

  6. Rebuttal to comment on “Modeling of opposition effects with ensembles of clusters: Interplay of various scattering mechanisms” by Elena V. Petrova, Victor P. Tishkovets, Klaus Jockers, 2007 [Icarus 188, 233 245

    NASA Astrophysics Data System (ADS)

    Petrova, Elena V.; Tishkovets, Victor P.; Jockers, Klaus

    2008-04-01

    Shkuratov and Zubko [Shkuratov, Yu.G., Zubko, E., 2008. Icarus 194, 850-852] criticize our paper [Petrova, E.V., Tishkovets, V.P., Jockers, K., 2007. Icarus 188, 233-245]. With this comment we reply to this criticism. We show that the experimental data and the modeling calculations presented by these authors cannot disprove the near-field effect as an important contributor to the scattering mechanisms considered in our paper.

  7. 75 FR 38019 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2C10 (Regional Jet Series 700 & 701...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-01

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2009... Directives; Bombardier, Inc. Model CL-600-2C10 (Regional Jet Series 700 & 701) Airplanes, Model CL-600-2D15 (Regional Jet Series 705) Airplanes, and Model CL-600-2D24 (Regional Jet Series 900) Airplanes Correction In...

  8. Project Icarus: The First Unmanned Interstellar Mission - Robotic Expansion and Technological Growth

    NASA Astrophysics Data System (ADS)

    Long, K. F.

    This paper discusses the important role of `disruptive technology' in altering the assessment on when the first unmanned interstellar probe mission is possible. Historical estimates suggest that such a mission is likely possible in the 23rd or 24th century. This paper argues that if such assessments also consider the role of high-growth exponential technology trends then in fact the first unmanned mission may be possible much earlier. The case study of a 100 year flyby space probe mission to Alpha Centauri 4.3 light years distance is examined, with an ideal cruise speed of 2,700 AU/year. Starting from an assumed mission capacity of 5 AU/year in 2020 a simple assessment shows that assuming a greater than ~8% technology growth annually in mission capacity (as measured by the attainment of cruise speed) it may be possible to launch an interstellar probe by around the year 2100. This depends upon significant and sustained science and technology research investment being made, particularly into space propulsion engineering in the near-term. This paper is a submission of the Project Icarus Study Group.

  9. Secular perihelion advances of the inner planets and asteroid Icarus

    NASA Astrophysics Data System (ADS)

    Wilhelm, Klaus; Dwivedi, Bhola N.

    2014-08-01

    A small effect expected from a recently proposed gravitational impact model (Wilhelm et al., 2013) is used to explain the remaining secular perihelion advance rates of the planets Mercury, Venus, Earth, Mars, and the asteroid (1566) Icarus-after taking into account the disturbances related to Newton’s Theory of Gravity. Such a rate was discovered by Le Verrier (1859) for Mercury and calculated by Einstein (1915, 1916) in the framework of his General Theory of Relativity (GTR). Accurate observations are now available for the inner Solar System objects with different orbital parameters. This is important, because it allowed us to demonstrate that the quantitative amount of the deviation from an 1/r potential is-under certain conditions-only dependent on the specific mass distribution of the Sun and not on the characteristics of the orbiting objects and their orbits. A displacement of the effective gravitational from the geometric centre of the Sun by about 4400 m towards each object is consistent with the observations and explains the secular perihelion advance rates.

  10. 75 FR 69030 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2C10 (Regional Jet Series 700, 701, & 702...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-10

    .... Model CL-600-2C10 (Regional Jet Series 700, 701, & 702) Airplanes, Model CL-600-2D15 (Regional Jet Series 705) Airplanes, and Model CL-600-2D24 (Regional Jet Series 900) Airplanes AGENCY: Federal Aviation... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010...

  11. 76 FR 13536 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2C10 (Regional Jet Series 700, 701, & 702...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-14

    .... Model CL-600-2C10 (Regional Jet Series 700, 701, & 702), Model CL-600-2D15 (Regional Jet Series 705), and Model CL-600-2D24 (Regional Jet Series 900) Airplanes AGENCY: Federal Aviation Administration (FAA... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2011...

  12. Simultaneous acquisition for T2 -T2 Exchange and T1 -T2 correlation NMR experiments

    NASA Astrophysics Data System (ADS)

    Montrazi, Elton T.; Lucas-Oliveira, Everton; Araujo-Ferreira, Arthur G.; Barsi-Andreeta, Mariane; Bonagamba, Tito J.

    2018-04-01

    The NMR measurements of longitudinal and transverse relaxation times and its multidimensional correlations provide useful information about molecular dynamics. However, these experiments are very time-consuming, and many researchers proposed faster experiments to reduce this issue. This paper presents a new way to simultaneously perform T2 -T2 Exchange and T1 -T2 correlation experiments by taking the advantage of the storage time and the two steps phase cycling used for running the relaxation exchange experiment. The data corresponding to each step is either summed or subtracted to produce the T2 -T2 and T1 -T2 data, enhancing the information obtained while maintaining the experiment duration. Comparing the results from this technique with traditional NMR experiments it was possible to validate the method.

  13. 21 CFR 600.81 - Distribution reports.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... and Research (see mailing addresses in § 600.2), information about the quantity of the product... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Distribution reports. 600.81 Section 600.81 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS...

  14. 21 CFR 600.81 - Distribution reports.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... and Research (see mailing addresses in § 600.2), information about the quantity of the product... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Distribution reports. 600.81 Section 600.81 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS...

  15. Measurement of the ( p, , T) Properties for Pure Hydrocarbons at Temperatures up to 600 K and Pressures up to 200 MPa

    NASA Astrophysics Data System (ADS)

    Ito, T.; Nagata, Y.; Miyamoto, H.

    2014-10-01

    The data available for the thermodynamic properties of propane, -butane, and isobutane at temperatures above 440 K are outdated and show significant discrepancies with each other. The ambiguity associated with these data could be limiting to the development of any understanding related to the effects of mixing of these substances with other materials such as , ammonia, and non-flammable or lower-flammable HFC refrigerants. In this study, the ( p, , T) properties of propane, -butane, and isobutane were measured at temperatures ranging from (360 to 600) K and pressures ranging from (50 to 200) MPa. Precise measurements were carried out using a metal-bellows variable volumometer with a thermostatted air bath. The expanded uncertainties in the temperature, pressure, and density measurements were estimated to be 5 mK, 0.02 MPa, and 0.88 kg m ( K, MPa), 0.76 kg ( K, MPa), 0.76 kg ( K, MPa), and 2.94 kg ( K, MPa), respectively. The data obtained throughout this study were systematically compared with the calculated values derived from the available equations of state. These models agree well with the measured data at higher temperatures up to 600 K, demonstrating their suitability for an effective and precise examination of the mixing effects of potential alternative mixtures.

  16. SPES-2, an experimental program to support the AP600 development

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tarantini, M.; Medich, C.

    1995-09-01

    In support of the development of the AP600 reactor, ENEA, ENEL, ANSALDO and Westinghouse have signed a research agreement. In the framework of this agreement a complex Full Height Full Pressure (FHFP) integral system testing program has been planned on SPES-2 facility. The main purpose of this paper is to point out the status of the test program; describe the hot per-operational test performed and the complete test matrix, giving all the necessary references on the work already published. Two identical Small Break LOCA transients, performed with Pressurizer to Core Make-up Tank (PRZ-CMT) balance line (Test S00203) and without PRZ-CMTmore » balance line (Test S00303) are then compared, to show how the SPES-2 facility can contribute in confirming the new AP600 reactor design choices and can give useful indications to designers. Although the detailed analysis of test data has not been completed, some consideration on the analytical tools utilized and on the SPES-2 capability to simulate the reference plant is then drawn.« less

  17. Hypersonic Wind Tunnel Nozzle Survivability for T&E

    DTIC Science & Technology

    2007-03-01

    Room-Temperature Compression Tests ..............................................................43 10. Strength of Hot-Rolled Inconel 600 (Ni-16Cr...6Fe, wt %) ...................................................45 11. Physical Properties of Inconel 600...Table 10. Strength of Hot-Rolled Inconel 600 (Ni-16Cr-6Fe, wt%) T, °C 0.2% Yield Stress (MPa) Ultimate Tensile Stress (MPa) 20 250 590 400 185 560

  18. Structure of the Human FANCL RING-Ube2T Complex Reveals Determinants of Cognate E3-E2 Selection

    PubMed Central

    Hodson, Charlotte; Purkiss, Andrew; Miles, Jennifer Anne; Walden, Helen

    2014-01-01

    Summary The combination of an E2 ubiquitin-conjugating enzyme with an E3 ubiquitin-ligase is essential for ubiquitin modification of a substrate. Moreover, the pairing dictates both the substrate choice and the modification type. The molecular details of generic E3-E2 interactions are well established. Nevertheless, the determinants of selective, specific E3-E2 recognition are not understood. There are ∼40 E2s and ∼600 E3s giving rise to a possible ∼24,000 E3-E2 pairs. Using the Fanconi Anemia pathway exclusive E3-E2 pair, FANCL-Ube2T, we report the atomic structure of the FANCL RING-Ube2T complex, revealing a specific and extensive network of additional electrostatic and hydrophobic interactions. Furthermore, we show that these specific interactions are required for selection of Ube2T over other E2s by FANCL. PMID:24389026

  19. 9 CFR 319.600 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false [Reserved] 319.600 Section 319.600 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... CERTIFICATION DEFINITIONS AND STANDARDS OF IDENTITY OR COMPOSITION Meat Snacks, Hors d'Oeuvres, Pizza, and...

  20. 9 CFR 319.600 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false [Reserved] 319.600 Section 319.600 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... CERTIFICATION DEFINITIONS AND STANDARDS OF IDENTITY OR COMPOSITION Meat Snacks, Hors d'Oeuvres, Pizza, and...

  1. 24 CFR 200.600 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Purpose. 200.600 Section 200.600 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS...

  2. 28 CFR 600.7 - Conduct and accountability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Conduct and accountability. 600.7 Section 600.7 Judicial Administration OFFICES OF INDEPENDENT COUNSEL, DEPARTMENT OF JUSTICE GENERAL POWERS OF SPECIAL COUNSEL § 600.7 Conduct and accountability. (a) A Special Counsel shall comply with the rules...

  3. 50 CFR 600.1203 - Prohibitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Shark Finning § 600.1203 Prohibitions. (a) In addition..., any of the following: (1) Engage in shark finning, as provided in § 600.1204(a) and (i). (2) Possess shark fins without the corresponding carcasses while on board a U.S. fishing vessel, as provided in...

  4. 50 CFR 600.1203 - Prohibitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Shark Finning § 600.1203 Prohibitions. (a) In addition..., any of the following: (1) Engage in shark finning, as provided in § 600.1204(a) and (i). (2) Possess shark fins without the corresponding carcasses while on board a U.S. fishing vessel, as provided in...

  5. 50 CFR 600.1203 - Prohibitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Shark Finning § 600.1203 Prohibitions. (a) In addition..., any of the following: (1) Engage in shark finning, as provided in § 600.1204(a) and (i). (2) Possess shark fins without the corresponding carcasses while on board a U.S. fishing vessel, as provided in...

  6. 50 CFR 600.1203 - Prohibitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Shark Finning § 600.1203 Prohibitions. (a) In addition..., any of the following: (1) Engage in shark finning, as provided in § 600.1204(a) and (i). (2) Possess shark fins without the corresponding carcasses while on board a U.S. fishing vessel, as provided in...

  7. 50 CFR 600.1203 - Prohibitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Shark Finning § 600.1203 Prohibitions. (a) In addition..., any of the following: (1) Engage in shark finning, as provided in § 600.1204(a) and (i). (2) Possess shark fins without the corresponding carcasses while on board a U.S. fishing vessel, as provided in...

  8. 40 CFR 600.011 - Incorporation by reference.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 1, 2010, IBR approved for §§ 600.113-08(f) and 600.113-12(f). (c) Society of Automotive Engineers... 1100a (Report of Human Factors Engineering Committee, Society of Automotive Engineers, approved September 1973 as revised September 1975), IBR approved for § 600.315-08(c). (2) SAE J1634, Electric Vehicle...

  9. 40 CFR 600.011 - Incorporation by reference.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 1, 2010, IBR approved for §§ 600.113-08(f) and 600.113-12(f). (c) Society of Automotive Engineers... 1100a (Report of Human Factors Engineering Committee, Society of Automotive Engineers, approved September 1973 as revised September 1975), IBR approved for § 600.315-08(c). (2) SAE J1634, Electric Vehicle...

  10. 34 CFR 600.40 - Loss of eligibility.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Loss of eligibility. 600.40 Section 600.40 Education..., DEPARTMENT OF EDUCATION INSTITUTIONAL ELIGIBILITY UNDER THE HIGHER EDUCATION ACT OF 1965, AS AMENDED Loss of Eligibility § 600.40 Loss of eligibility. (a)(1) Except as provided in paragraphs (a) (2) and (3) of this...

  11. 30 CFR 250.600 - General requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false General requirements. 250.600 Section 250.600 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE... leased), the national security or defense, or the marine, coastal, or human environment. ...

  12. Integrated Research on the Development of Global Climate Risk Management Strategies - Framework and Initial Results of the Research Project ICA-RUS

    NASA Astrophysics Data System (ADS)

    Emori, Seita; Takahashi, Kiyoshi; Yamagata, Yoshiki; Oki, Taikan; Mori, Shunsuke; Fujigaki, Yuko

    2013-04-01

    With the aim of proposing strategies of global climate risk management, we have launched a five-year research project called ICA-RUS (Integrated Climate Assessment - Risks, Uncertainties and Society). In this project with the phrase "risk management" in its title, we aspire for a comprehensive assessment of climate change risks, explicit consideration of uncertainties, utilization of best available information, and consideration of every possible conditions and options. We also regard the problem as one of decision-making at the human level, which involves social value judgments and adapts to future changes in circumstances. The ICA-RUS project consists of the following five themes: 1) Synthesis of global climate risk management strategies, 2) Optimization of land, water and ecosystem uses for climate risk management, 3) Identification and analysis of critical climate risks, 4) Evaluation of climate risk management options under technological, social and economic uncertainties and 5) Interactions between scientific and social rationalities in climate risk management (see also: http://www.nies.go.jp/ica-rus/en/). For the integration of quantitative knowledge of climate change risks and responses, we apply a tool named AIM/Impact [Policy], which consists of an energy-economic model, a simplified climate model and impact projection modules. At the same time, in order to make use of qualitative knowledge as well, we hold monthly project meetings for the discussion of risk management strategies and publish annual reports based on the quantitative and qualitative information. To enhance the comprehensiveness of the analyses, we maintain an inventory of risks and risk management options. The inventory is revised iteratively through interactive meetings with stakeholders such as policymakers, government officials and industrial representatives.

  13. Obtaining T1-T2 distribution functions from 1-dimensional T1 and T2 measurements: The pseudo 2-D relaxation model

    NASA Astrophysics Data System (ADS)

    Williamson, Nathan H.; Röding, Magnus; Galvosas, Petrik; Miklavcic, Stanley J.; Nydén, Magnus

    2016-08-01

    We present the pseudo 2-D relaxation model (P2DRM), a method to estimate multidimensional probability distributions of material parameters from independent 1-D measurements. We illustrate its use on 1-D T1 and T2 relaxation measurements of saturated rock and evaluate it on both simulated and experimental T1-T2 correlation measurement data sets. Results were in excellent agreement with the actual, known 2-D distribution in the case of the simulated data set. In both the simulated and experimental case, the functional relationships between T1 and T2 were in good agreement with the T1-T2 correlation maps from the 2-D inverse Laplace transform of the full 2-D data sets. When a 1-D CPMG experiment is combined with a rapid T1 measurement, the P2DRM provides a double-shot method for obtaining a T1-T2 relationship, with significantly decreased experimental time in comparison to the full T1-T2 correlation measurement.

  14. High-field 1H T1 and T2 NMR relaxation time measurements of H2O in homeopathic preparations of quartz, sulfur, and copper sulfate

    NASA Astrophysics Data System (ADS)

    Baumgartner, Stephan; Wolf, Martin; Skrabal, Peter; Bangerter, Felix; Heusser, Peter; Thurneysen, André; Wolf, Ursula

    2009-09-01

    Quantitative meta-analyses of randomized clinical trials investigating the specific therapeutic efficacy of homeopathic remedies yielded statistically significant differences compared to placebo. Since the remedies used contained mostly only very low concentrations of pharmacologically active compounds, these effects cannot be accounted for within the framework of current pharmacology. Theories to explain clinical effects of homeopathic remedies are partially based upon changes in diluent structure. To investigate the latter, we measured for the first time high-field (600/500 MHz) 1H T1 and T2 nuclear magnetic resonance relaxation times of H2O in homeopathic preparations with concurrent contamination control by inductively coupled plasma mass spectrometry (ICP-MS). Homeopathic preparations of quartz (10 c-30 c, n = 21, corresponding to iterative dilutions of 100-10-100-30), sulfur (13 x-30 x, n = 18, 10-13-10-30), and copper sulfate (11 c-30 c, n = 20, 100-11-100-30) were compared to n = 10 independent controls each (analogously agitated dilution medium) in randomized and blinded experiments. In none of the samples, the concentration of any element analyzed by ICP-MS exceeded 10 ppb. In the first measurement series (600 MHz), there was a significant increase in T1 for all samples as a function of time, and there were no significant differences between homeopathic potencies and controls. In the second measurement series (500 MHz) 1 year after preparation, we observed statistically significant increased T1 relaxation times for homeopathic sulfur preparations compared to controls. Fifteen out of 18 correlations between sample triplicates were higher for controls than for homeopathic preparations. No conclusive explanation for these phenomena can be given at present. Possible hypotheses involve differential leaching from the measurement vessel walls or a change in water molecule dynamics, i.e., in rotational correlation time and/or diffusion. Homeopathic preparations

  15. 10 CFR 600.241 - Financial reporting.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Financial reporting. 600.241 Section 600.241 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES Uniform Administrative....241 Financial reporting. (a) General. (1) Except as provided in paragraphs (a) (2) and (5) of this...

  16. 24 CFR 232.600 - Title evidence.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Title evidence. 232.600 Section 232.600 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES MORTGAGE...

  17. 10 CFR 600.241 - Financial reporting.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Financial reporting. 600.241 Section 600.241 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES Uniform Administrative....241 Financial reporting. (a) General. (1) Except as provided in paragraphs (a) (2) and (5) of this...

  18. Design and synthesis of N-(4-aminopyridin-2-yl)amides as B-Raf(V600E) inhibitors.

    PubMed

    Li, Xiaokai; Shen, Jiayi; Tan, Li; Zhang, Zhang; Gao, Donglin; Luo, Jinfeng; Cheng, Huimin; Zhou, Xiaoping; Ma, Jie; Ding, Ke; Lu, Xiaoyun

    2016-06-15

    B-Raf(V600E) was an effective target for the treatment of human cancers. Based on a pan-Raf inhibitor TAK-632, a series of N-(4-aminopyridin-2-yl)amide derivatives were designed as novel B-Raf(V600E) inhibitors. Detailed structure-activity studies of the compounds revealed that most of the compounds displayed potent enzymatic activity against B-Raf(V600E), and good selectivity over B-Raf(WT). One of the most promising compound 4l exhibited potent inhibitory activity with an IC50 value of 38nM for B-raf(V600E), and displayed antiproliferative activities against colo205 and HT29 cells with IC50 values of 0.136 and 0.094μM, respectively. It also displayed good selectivity on both enzymatic and cellular assays over B-Raf(WT). These inhibitors may serve as lead compounds for further developing novel B-Raf(V600E) inhibitors as anticancer drugs. Copyright © 2016 Elsevier Ltd. All rights reserved.

  19. Endurance and failure characteristics of modified Vasco X-2, CBS 600 and AISI 9310 spur gears. [aircraft construction materials

    NASA Technical Reports Server (NTRS)

    Townsend, D. P.; Zaretsky, E. V.

    1980-01-01

    Gear endurance tests and rolling-element fatigue tests were conducted to compare the performance of spur gears made from AISI 9310, CBS 600 and modified Vasco X-2 and to compare the pitting fatigue lives of these three materials. Gears manufactured from CBS 600 exhibited lives longer than those manufactured from AISI 9310. However, rolling-element fatigue tests resulted in statistically equivalent lives. Modified Vasco X-2 exhibited statistically equivalent lives to AISI 9310. CBS 600 and modified Vasco X-2 gears exhibited the potential of tooth fracture occurring at a tooth surface fatigue pit. Case carburization of all gear surfaces for the modified Vasco X-2 gears results in fracture at the tips of the gears.

  20. 28 CFR 600.10 - No creation of rights.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false No creation of rights. 600.10 Section 600.10 Judicial Administration OFFICES OF INDEPENDENT COUNSEL, DEPARTMENT OF JUSTICE GENERAL POWERS OF SPECIAL COUNSEL § 600.10 No creation of rights. The regulations in this part are not intended to, do not...

  1. 28 CFR 600.10 - No creation of rights.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false No creation of rights. 600.10 Section 600.10 Judicial Administration OFFICES OF INDEPENDENT COUNSEL, DEPARTMENT OF JUSTICE GENERAL POWERS OF SPECIAL COUNSEL § 600.10 No creation of rights. The regulations in this part are not intended to, do not...

  2. 28 CFR 600.10 - No creation of rights.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false No creation of rights. 600.10 Section 600.10 Judicial Administration OFFICES OF INDEPENDENT COUNSEL, DEPARTMENT OF JUSTICE GENERAL POWERS OF SPECIAL COUNSEL § 600.10 No creation of rights. The regulations in this part are not intended to, do not...

  3. 28 CFR 600.10 - No creation of rights.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false No creation of rights. 600.10 Section 600.10 Judicial Administration OFFICES OF INDEPENDENT COUNSEL, DEPARTMENT OF JUSTICE GENERAL POWERS OF SPECIAL COUNSEL § 600.10 No creation of rights. The regulations in this part are not intended to, do not...

  4. 28 CFR 600.10 - No creation of rights.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false No creation of rights. 600.10 Section 600.10 Judicial Administration OFFICES OF INDEPENDENT COUNSEL, DEPARTMENT OF JUSTICE GENERAL POWERS OF SPECIAL COUNSEL § 600.10 No creation of rights. The regulations in this part are not intended to, do not...

  5. A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells.

    PubMed

    Stuart, Scott A; Houel, Stephane; Lee, Thomas; Wang, Nan; Old, William M; Ahn, Natalie G

    2015-06-01

    Inhibitors of oncogenic B-RAF(V600E) and MKK1/2 have yielded remarkable responses in B-RAF(V600E)-positive melanoma patients. However, the efficacy of these inhibitors is limited by the inevitable onset of resistance. Despite the fact that these inhibitors target the same pathway, combination treatment with B-RAF(V600E) and MKK1/2 inhibitors has been shown to improve both response rates and progression-free survival in B-RAF(V600E) melanoma patients. To provide insight into the molecular nature of the combinatorial response, we used quantitative mass spectrometry to characterize the inhibitor-dependent phosphoproteome of human melanoma cells treated with the B-RAF(V600E) inhibitor PLX4032 (vemurafenib) or the MKK1/2 inhibitor AZD6244 (selumetinib). In three replicate experiments, we quantified changes at a total of 23,986 phosphosites on 4784 proteins. This included 1317 phosphosites that reproducibly decreased in response to at least one inhibitor. Phosphosites that responded to both inhibitors grouped into networks that included the nuclear pore complex, growth factor signaling, and transcriptional regulators. Although the majority of phosphosites were responsive to both inhibitors, we identified 16 sites that decreased only in response to PLX4032, suggesting rare instances where oncogenic B-RAF signaling occurs in an MKK1/2-independent manner. Only two phosphosites were identified that appeared to be uniquely responsive to AZD6244. When cells were treated with the combination of AZD6244 and PLX4032 at subsaturating concentrations (30 nm), responses at nearly all phosphosites were additive. We conclude that AZD6244 does not substantially widen the range of phosphosites inhibited by PLX4032 and that the benefit of the drug combination is best explained by their additive effects on suppressing ERK1/2 signaling. Comparison of our results to another recent ERK1/2 phosphoproteomics study revealed a surprising degree of variability in the sensitivity of phosphosites to

  6. Catalytic properties of thimet oligopeptidase H600A mutant

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Machado, Mauricio F.M.; Marcondes, Marcelo F.; Rioli, Vanessa

    2010-04-02

    Thimet oligopeptidase (EC 3.4.24.15, TOP) is a metallo-oligopeptidase that participates in the intracellular metabolism of peptides. Predictions based on structurally analogous peptidases (Dcp and ACE-2) show that TOP can present a hinge-bend movement during substrate hydrolysis, what brings some residues closer to the substrate. One of these residues that in TOP crystallographic structure are far from the catalytic residues, but, moves toward the substrate considering this possible structural reorganization is His{sup 600}. In the present work, the role of His{sup 600} of TOP was investigated by site-directed mutagenesis. TOP H600A mutant was characterized through analysis of S{sub 1} and S{submore » 1}' specificity, pH-activity profile and inhibition by JA-2. Results showed that TOP His{sup 600} residue makes important interactions with the substrate, supporting the prediction that His{sup 600} moves toward the substrate due to a hinge movement similar to the Dcp and ACE-2. Furthermore, the mutation H600A affected both K{sub m} and k{sub cat}, showing the importance of His{sup 600} for both substrate binding and/or product release from active site. Changes in the pH-profile may indicate also the participation of His{sup 600} in TOP catalysis, transferring a proton to the newly generated NH{sub 2}-terminus or helping Tyr{sup 605} and/or Tyr{sup 612} in the intermediate oxyanion stabilization.« less

  7. 76 FR 28914 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-19

    ... of the rudder system design. Rudder pedal sensitivity on Model A300-600 and A310 series airplanes is... B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R Variant F Airplanes (Collectively Called A300-600 Series Airplanes); and Model A310 Series Airplanes AGENCY: Federal Aviation...

  8. ICARUS study: prevalence and clinical features of impulse control disorders in Parkinson's disease.

    PubMed

    Antonini, Angelo; Barone, Paolo; Bonuccelli, Ubaldo; Annoni, Karin; Asgharnejad, Mahnaz; Stanzione, Paolo

    2017-04-01

    Impulse control disorders/other compulsive behaviours ('ICD behaviours') occur in Parkinson's disease (PD), but prospective studies are scarce, and prevalence and clinical characteristics of patients are insufficiently defined. To assess the presence of ICD behaviours over a 2-year period, and evaluate patients' clinical characteristics. A prospective, non-interventional, multicentre study (ICARUS (Impulse Control disorders And the association of neuRopsychiatric symptoms, cognition and qUality of life in ParkinSon disease); SP0990) in treated Italian PD outpatients. Study visits: baseline, year 1, year 2. Surrogate primary variable: presence of ICD behaviours and five ICD subtypes assessed by modified Minnesota Impulsive Disorder Interview (mMIDI). 1069/1095 (97.6%) patients comprised the Full Analysis Set. Point prevalence of ICD behaviours (mMIDI; primary analysis) was stable across visits: 28.6% (306/1069) at baseline, 29.3% (292/995) at year 1, 26.5% (245/925) at year 2. The most prevalent subtype was compulsive eating, followed by punding, compulsive sexual behaviour, gambling and buying disorder. Patients who were ICD positive at baseline were more likely to be male, younger, younger at PD onset, have longer disease duration, more severe non-motor symptoms (including mood and sexual function), depressive symptoms, sleep impairment and poorer PD-related quality of life. However, they did not differ from the ICD-negative patients in their severity of PD functional disability, motor performance and cognitive function. Prevalence of ICD behaviours was relatively stable across the 2-year observational period. ICD-positive patients had more severe depression, poorer sleep quality and reduced quality of life. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  9. Status of the OPERA experiment

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Russo, A.

    2011-11-23

    The OPERA experiment in the underground Gran Sasso Laboratory (LNGS) has been designed to perform the first detection of neutrino oscillations in direct appearance mode in the muon to tau neutrino channel. The detector is hybrid, being made of an emulsion/lead target and of electronic detectors. It is placed in the CNGS neutrino beam 733 km away from the neutrino source. Runs with CNGS neutrinos were successfully carried out from 2008 and the following years. The analysis of a sample of events corresponding to 1.89x10{sup 19} p.o.t. in the CERN CNGS {nu}{sub {mu}} beam yielded the observation of a firstmore » candidate {nu}{sub {tau}} CC interaction. The topology and kinematics of this candidate event is described in detail. The background sources are explained and the significance of the observation of the first {nu}{sub {tau}} event candidate is assessed.« less

  10. Combined "Infiltrating Astrocytoma/Pleomorphic Xanthoastrocytoma" Harboring IDH1 R132H and BRAF V600E Mutations.

    PubMed

    Yamada, Seiji; Kipp, Benjamin R; Voss, Jesse S; Giannini, Caterina; Raghunathan, Aditya

    2016-02-01

    Pleomorphic xanthoastrocytoma (PXA) has rarely been reported in combination with infiltrating glioma, historically interpreted as a "collision tumor." Isocitrate dehydrogenase 1 (IDH1) and BRAF V600E mutations are usually not concurrent. The former is typical of adult infiltrating gliomas, and the latter is identified in a variety of primary central nervous system neoplasms, including PXA, ganglioglioma, pilocytic astrocytoma, and rarely infiltrating gliomas. We report the case of a 56-year-old man presenting with seizures and headaches. Magnetic resonance imaging revealed a large right temporal lobe mass with low T1 and high T2/FLAIR signal and a discrete contrast-enhancing focus. Histologically, the tumor showed 2 distinct components: an infiltrating astrocytoma harboring 5 mitoses/10 high-power fields and a relatively circumscribed focus, resembling PXA with, at most, 2 mitoses/10 high-power fields. No microvascular proliferation or necrosis was present in either component. The infiltrating astrocytoma component contained numerous axons, whereas the PXA-like component had sparse axons, as demonstrated by the neurofilament immunostain. Both components were positive for the mutant IDH1 R132H and showed loss of ATRX expression, whereas BRAF V600E was restricted to the PXA-like component. On sequencing of the 2 components separately after microdissection, both showed identical IDH1 R132H and TP53 R273C point mutations, whereas the BRAF V600E mutation was limited to the PXA-like component. These findings are consistent with clonal expansion of a morphologically distinct focus, harboring a private BRAF V600E mutation within an IDH1-mutant glioma. Intratumoral heterogeneity and clonal evolution, as seems to have occurred here, suggest reevaluation of "collision tumors" as a concept.

  11. 50 CFR 600.511 - Fishery closure procedures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Fishery closure procedures. 600.511 Section 600.511 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND... Fishery closure procedures. (a) Activity Codes 1 and 2 for a fishery are automatically canceled in the...

  12. 76 FR 33982 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2C10 (Regional Jet Series 700, 701, & 702...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-10

    ... transportation, Aircraft, Aviation safety, Incorporation by reference, Safety. Adoption of the Amendment... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2011... Airworthiness Directives; Bombardier, Inc. Model CL-600-2C10 (Regional Jet Series 700, 701, & 702), Model CL-600...

  13. 9 CFR 590.600 - Application for exemption.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Application for exemption. 590.600 Section 590.600 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION INSPECTION OF EGGS AND EGG PRODUCTS (EGG PRODUCTS INSPECTION ACT) Exempted Egg...

  14. 9 CFR 590.600 - Application for exemption.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Application for exemption. 590.600 Section 590.600 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION INSPECTION OF EGGS AND EGG PRODUCTS (EGG PRODUCTS INSPECTION ACT) Exempted Egg...

  15. 76 FR 6581 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-07

    ... B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R Variant F Airplanes (Collectively Called A300-600 Series Airplanes) AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of... design review against explosion risks. During improvement of the protection of fuel pump wiring against...

  16. 76 FR 27242 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    ... Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R Variant F Airplanes (Collectively Called A300-600 Series Airplanes) AGENCY: Federal Aviation... required to conduct a design review against explosion risks. During improvement of the protection of fuel...

  17. 75 FR 68695 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2C10 (Regional Jet Series 700, 701, & 702...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-09

    ... the AD docket. List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010... Airworthiness Directives; Bombardier, Inc. Model CL-600-2C10 (Regional Jet Series 700, 701, & 702), Model CL-600...

  18. 75 FR 53849 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2C10 (Regional Jet Series 700, 701, & 702...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-02

    ... the AD docket. List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010... Airworthiness Directives; Bombardier, Inc. Model CL-600-2C10 (Regional Jet Series 700, 701, & 702); Model CL-600...

  19. 75 FR 60611 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-01

    ... Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and Model A300 C4...; Model A300 B4-601, B4- 603, B4-620, B4-622, B4-605R, B4-622R, F4-605R, F4-622R, and C4-605R Variant F...-- Dated-- A300 series airplanes......... A300-32A0447..... April 22, 2004. A300 B4-600, B4-600R, and F4...

  20. 40 CFR 600.107-78 - Fuel specifications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... and Later Model Year Automobiles-Test Procedures § 600.107-78 Fuel specifications. (a) The test fuel... test fuel specifications for diesel automobiles are given in paragraphs (b) (1) and (2) of § 86.113 of... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Fuel specifications. 600.107-78...

  1. Early anthropogenic impact on Western Central African rainforests 2,600 y ago

    NASA Astrophysics Data System (ADS)

    Garcin, Yannick; Deschamps, Pierre; Ménot, Guillemette; de Saulieu, Geoffroy; Schefuß, Enno; Sebag, David; Dupont, Lydie M.; Oslisly, Richard; Brademann, Brian; Mbusnum, Kevin G.; Onana, Jean-Michel; Ako, Andrew A.; Epp, Laura S.; Tjallingii, Rik; Strecker, Manfred R.; Brauer, Achim; Sachse, Dirk

    2018-03-01

    A potential human footprint on Western Central African rainforests before the Common Era has become the focus of an ongoing controversy. Between 3,000 y ago and 2,000 y ago, regional pollen sequences indicate a replacement of mature rainforests by a forest–savannah mosaic including pioneer trees. Although some studies suggested an anthropogenic influence on this forest fragmentation, current interpretations based on pollen data attribute the ‘‘rainforest crisis’’ to climate change toward a drier, more seasonal climate. A rigorous test of this hypothesis, however, requires climate proxies independent of vegetation changes. Here we resolve this controversy through a continuous 10,500-y record of both vegetation and hydrological changes from Lake Barombi in Southwest Cameroon based on changes in carbon and hydrogen isotope compositions of plant waxes. δ13C-inferred vegetation changes confirm a prominent and abrupt appearance of C4 plants in the Lake Barombi catchment, at 2,600 calendar years before AD 1950 (cal y BP), followed by an equally sudden return to rainforest vegetation at 2,020 cal y BP. δD values from the same plant wax compounds, however, show no simultaneous hydrological change. Based on the combination of these data with a comprehensive regional archaeological database we provide evidence that humans triggered the rainforest fragmentation 2,600 y ago. Our findings suggest that technological developments, including agricultural practices and iron metallurgy, possibly related to the large-scale Bantu expansion, significantly impacted the ecosystems before the Common Era.

  2. The fate of verocytotoxigenic Escherichia coli C600φ3538(Δvtx2 ::cat) and its vtx2 prophage during grass silage preparation.

    PubMed

    Nyambe, S; Burgess, C; Whyte, P; O'Kiely, P; Bolton, D

    2017-05-01

    Silage is grass, preserved by fermentation and used as winter feed for cattle. The impact of a range of current grass silage preparation practices on the survival of Escherichia coli C600φ3538(Δvtx 2 ::cat) and on the induction, release and infectivity of free phage were investigated. Wilted and fresh grass samples, from plots with and without slurry application, were ensiled with or without formic acid. Each treatment combination was inoculated with approximately 6 log 10 CFU per g E. coli C600φ3538(Δvtx 2 ::cat) (donor strain) and E. coli C600::kanamycin R (recipient strain) in test-tube model silos and incubated in the dark at 15°C. The physico-chemical (pH, ammonia, ethanol, lactic acid and volatile fatty acids) and microbiological (total viable counts, TVC, total Enterobacteriaceae counts, TEC, E. coli counts, ECC and lactic acid bacteria, LAB) properties of each fermentation were monitored throughout the experiment as were the concentrations of E. coli C600φ3538(Δvtx 2 ::cat), E. coli C600::kanamycin R , free phage and transductants, using culture and PCR-based methods. Over the course of the experiment the pH of the grass samples typically decreased by 2 pH units. TVC, TEC and ECC decreased by up to 2·3, 6·4 and 6·2 log 10 CFU per g, respectively, while the LAB counts remained relatively stable at 5·2-7·1 log 10 CFU per g. Both donor and recipient strains decreased by approximately 5 log 10 CFU per g. Free phages were detected in all treatments and transductants were detected and confirmed by PCR in the silo containing wilted grass, pretreated with slurry and ensiled without formic acid. Verocytotoxigenic E. coli may survive the ensiling process and the conditions encountered are sufficient to induce vtx 2 bacteriophage leading to low levels of phage-mediated vtx 2 gene transfer. These studies suggest that the ensiling of grass may create an environment which facilitates the emergence of new verocytotoxigenic E. coli. © 2017 The Society

  3. 10 CFR 600.20 - Maximum DOE obligation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... DOE obligation. (a) The maximum DOE obligation to the recipient is— (1) For monetary awards, the amount shown in the award as the amount of DOE funds obligated, and (2) Any designated property. (b) DOE... 10 Energy 4 2011-01-01 2011-01-01 false Maximum DOE obligation. 600.20 Section 600.20 Energy...

  4. 10 CFR 600.20 - Maximum DOE obligation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... DOE obligation. (a) The maximum DOE obligation to the recipient is— (1) For monetary awards, the amount shown in the award as the amount of DOE funds obligated, and (2) Any designated property. (b) DOE... 10 Energy 4 2013-01-01 2013-01-01 false Maximum DOE obligation. 600.20 Section 600.20 Energy...

  5. 10 CFR 600.20 - Maximum DOE obligation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... DOE obligation. (a) The maximum DOE obligation to the recipient is— (1) For monetary awards, the amount shown in the award as the amount of DOE funds obligated, and (2) Any designated property. (b) DOE... 10 Energy 4 2012-01-01 2012-01-01 false Maximum DOE obligation. 600.20 Section 600.20 Energy...

  6. 10 CFR 600.20 - Maximum DOE obligation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... DOE obligation. (a) The maximum DOE obligation to the recipient is— (1) For monetary awards, the amount shown in the award as the amount of DOE funds obligated, and (2) Any designated property. (b) DOE... 10 Energy 4 2014-01-01 2014-01-01 false Maximum DOE obligation. 600.20 Section 600.20 Energy...

  7. Comparative Evaluation of Chitosan Nerve Guides with Regular or Increased Bendability for Acute and Delayed Peripheral Nerve Repair: A Comprehensive Comparison with Autologous Nerve Grafts and Muscle-in-Vein Grafts.

    PubMed

    Stößel, Maria; Wildhagen, Vivien M; Helmecke, Olaf; Metzen, Jennifer; Pfund, Charlotte B; Freier, Thomas; Haastert-Talini, Kirsten

    2018-05-08

    Reconstruction of joint-crossing digital nerves requires the application of nerve guides with a much higher flexibility than used for peripheral nerve repair along larger bones. Nevertheless, collapse-resistance should be preserved to avoid secondary damage to the regrowing nerve tissue. In recent years, we presented chitosan nerve guides (CNGs) to be highly supportive for the regeneration of critical gap length peripheral nerve defects in the rat. Now, we evidently increased the bendability of regular CNGs (regCNGs) by developing a wavy wall structure, that is, corrugated CNGs (corrCNGs). In a comprehensive in vivo study, we compared both types of CNGs with clinical gold standard autologous nerve grafts (ANGs) and muscle-in-vein grafts (MVGs) that have recently been highlighted in the literature as a suitable alternative to ANGs. We reconstructed rat sciatic nerves over a critical gap length of 15 mm either immediately upon transection or after a delay period of 45 days. Electrodiagnostic measurements were applied to monitor functional motor recovery at 60, 90, 120, and 150 (only delayed repair) days postreconstruction. Upon explanation, tube properties were analyzed. Furthermore, distal nerve ends were evaluated using histomorphometry, while connective tissue specimens were subjected to immunohistological stainings. After 120 days (acute repair) or 150 days (delayed repair), respectively, compression-stability of regCNGs was slightly increased while it remained stable in corrCNGs. In both substudies, regCNGs and corrCNGs supported functional recovery of distal plantar muscles in a similar way and to a greater extent when compared with MVGs, while ANGs demonstrated the best support of regeneration. Anat Rec, 2018. © 2018 Wiley Periodicals, Inc. © 2018 Wiley Periodicals, Inc.

  8. SPES-2, AP600 intergral system test S01007 2 inch CL to core make-up tank pressure balance line break

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bacchiani, M.; Medich, C.; Rigamonti, M.

    1995-09-01

    The SPES-2 is a full height, full pressure experimental test facility reproducing the Westinghouse AP600 reactor with a scaling factor of 1/395. The experimental plant, designed and operated by SIET in Piacenza, consists of a full simulation of the AP600 primary core cooling system including all the passive and active safety systems. In 1992, Westinghouse, in cooperation with ENEL (Ente Nazionale per l` Energia Elettrica), ENEA (Enter per le numove Technlogie, l` Energia e l` Ambient), Siet (Societa Informazioni Esperienze Termoidraulich) and ANSALDO developed an experimental program to test the integrated behaviour of the AP600 passive safety systems. The SPES-2more » test matrix, concluded in November 1994, has examined the AP600 passive safety system response for a range of small break LOCAs at different locations on the primary system and on the passive system lines; single steam generator tube ruptures with passive and active safety systems and a main steam line break transient to demonstrate the boration capability of passive safety systems for rapid cooldown. Each of the tests has provided detailed experimental results for verification of the capability of the analysis methods to predict the integrated passive safety system behaviour. Cold and hot shakedown tests have been performed on the facility to check the characteristics of the plant before starting the experimental campaign. The paper first presents a description of the SPES-2 test facility then the main results of S01007 test {open_quotes}2{close_quotes} Cold Leg (CL) to Core Make-up Tank (CMT) pressure balance line break{close_quotes} are reported and compared with predictions performed using RELAP5/mod3/80 obtained by ANSALDO through agreement with U.S.N.R.C. (U.S. Nuclear Regulatory Commission). The SPES-2 nodalization and all the calculations here presented were performed by ANSALDO and sponsored by ENEL as a part of pre-test predictions for SPES-2.« less

  9. Development of ultra-short PCR assay to reveal BRAF V600 mutation status in Thai colorectal cancer tissues.

    PubMed

    Chat-Uthai, Nunthawut; Vejvisithsakul, Pichpisith; Udommethaporn, Sutthirat; Meesiri, Puttarakun; Danthanawanit, Chetiya; Wongchai, Yannawan; Teerapakpinyo, Chinachote; Shuangshoti, Shanop; Poungvarin, Naravat

    2018-01-01

    The protein kinase BRAF is one of the key players in regulating cellular responses to extracellular signals. Somatic mutations of the BRAF gene, causing constitutive activation of BRAF, have been found in various types of human cancers such as malignant melanoma, and colorectal cancer. BRAF V600E and V600K, most commonly observed mutations in these cancers, may predict response to targeted therapies. Many techniques suffer from a lack of diagnostic sensitivity in mutation analysis in clinical samples with a low cancer cell percentage or poor-quality fragmented DNA. Here we present allele-specific real-time PCR assay for amplifying 35- to 45-base target sequences in BRAF gene. Forward primer designed for BRAF V600E detection is capable of recognizing both types of BRAF V600E mutation, i.e. V600E1 (c.1799T>A) and V600E2 (c.1799_1800delTGinsAA), as well as complex tandem mutation caused by nucleotide changes in codons 600 and 601. We utilized this assay to analyze Thai formalin-fixed paraffin-embedded tissues. Forty-eight percent of 178 Thai colorectal cancer tissues has KRAS mutation detected by highly sensitive commercial assays. Although these DNA samples contain low overall yield of amplifiable DNA, our newly-developed assay successfully revealed BRAF V600 mutations in 6 of 93 formalin-fixed paraffin-embedded colorectal cancer tissues which KRAS mutation was not detected. Ultra-short PCR assay with forward mutation-specific primers is potentially useful to detect BRAF V600 mutations in highly fragmented DNA specimens from cancer patients.

  10. CCD Photometer Installed on the Telescope - 600 OF the Shamakhy Astrophysical Observatory: I. Adjustment of CCD Photometer with Optics - 600

    NASA Astrophysics Data System (ADS)

    Lyuty, V. M.; Abdullayev, B. I.; Alekberov, I. A.; Gulmaliyev, N. I.; Mikayilov, Kh. M.; Rustamov, B. N.

    2009-12-01

    Short description of optical and electric scheme of CCD photometer with camera U-47 installed on the Cassegrain focus of ZEISS-600 telescope of the ShAO NAS Azerbaijan is provided. The reducer of focus with factor of reduction 1.7 is applied. It is calculated equivalent focal distances of a telescope with a focus reducer. General calculations of optimum distance from focal plane and t sizes of optical filters of photometer are presented.

  11. Early anthropogenic impact on Western Central African rainforests 2,600 y ago.

    PubMed

    Garcin, Yannick; Deschamps, Pierre; Ménot, Guillemette; de Saulieu, Geoffroy; Schefuß, Enno; Sebag, David; Dupont, Lydie M; Oslisly, Richard; Brademann, Brian; Mbusnum, Kevin G; Onana, Jean-Michel; Ako, Andrew A; Epp, Laura S; Tjallingii, Rik; Strecker, Manfred R; Brauer, Achim; Sachse, Dirk

    2018-03-27

    A potential human footprint on Western Central African rainforests before the Common Era has become the focus of an ongoing controversy. Between 3,000 y ago and 2,000 y ago, regional pollen sequences indicate a replacement of mature rainforests by a forest-savannah mosaic including pioneer trees. Although some studies suggested an anthropogenic influence on this forest fragmentation, current interpretations based on pollen data attribute the ''rainforest crisis'' to climate change toward a drier, more seasonal climate. A rigorous test of this hypothesis, however, requires climate proxies independent of vegetation changes. Here we resolve this controversy through a continuous 10,500-y record of both vegetation and hydrological changes from Lake Barombi in Southwest Cameroon based on changes in carbon and hydrogen isotope compositions of plant waxes. [Formula: see text] 13 C-inferred vegetation changes confirm a prominent and abrupt appearance of C 4 plants in the Lake Barombi catchment, at 2,600 calendar years before AD 1950 (cal y BP), followed by an equally sudden return to rainforest vegetation at 2,020 cal y BP. [Formula: see text]D values from the same plant wax compounds, however, show no simultaneous hydrological change. Based on the combination of these data with a comprehensive regional archaeological database we provide evidence that humans triggered the rainforest fragmentation 2,600 y ago. Our findings suggest that technological developments, including agricultural practices and iron metallurgy, possibly related to the large-scale Bantu expansion, significantly impacted the ecosystems before the Common Era.

  12. Colloidal chitin nanogels: A plethora of applications under one shell.

    PubMed

    Vishnu Priya, M; Sabitha, M; Jayakumar, R

    2016-01-20

    Chitin nanogels (CNGs) are a relatively new class of natural polymeric nanomaterials which have a large potential in the field of drug delivery and nanotherapeutics. These nanogels being very biocompatible are non-toxic when internalized by cells. In this review various properties, preparation techniques and applications of CNGs have been described. CNGs because of their nano-size possess certain unique properties which enable them to be used in a number of biomedical applications. CNGs are prepared by simple regeneration technique without using any cross-linkers. Various polymers, drugs and fluorescent dyes can be blended or incorporated or labelled with the chitin hydrogel network. Drugs and molecules encapsulated within CNGs can be used for targeted delivery, in vivo monitoring or even for therapeutic purposes. Here various applications of CNGs in the field of drug delivery, imaging, sensing and therapeutics have been discussed. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. 41 CFR 101-30.600 - Scope of subpart.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Scope of subpart. 101-30.600 Section 101-30.600 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30...

  14. 41 CFR 101-30.600 - Scope of subpart.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 41 Public Contracts and Property Management 2 2014-07-01 2012-07-01 true Scope of subpart. 101-30.600 Section 101-30.600 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30...

  15. 41 CFR 101-30.600 - Scope of subpart.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 41 Public Contracts and Property Management 2 2011-07-01 2007-07-01 true Scope of subpart. 101-30.600 Section 101-30.600 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30...

  16. Cardiac Iron Determines Cardiac T2*, T2, and T1 in the Gerbil Model of Iron Cardiomyopathy

    PubMed Central

    Wood, John C.; Otto-Duessel, Maya; Aguilar, Michelle; Nick, Hanspeter; Nelson, Marvin D.; Coates, Thomas D.; Pollack, Harvey; Moats, Rex

    2010-01-01

    Background Transfusional therapy for thalassemia major and sickle cell disease can lead to iron deposition and damage to the heart, liver, and endocrine organs. Iron causes the MRI parameters T1, T2, and T2* to shorten in these organs, which creates a potential mechanism for iron quantification. However, because of the danger and variability of cardiac biopsy, tissue validation of cardiac iron estimates by MRI has not been performed. In this study, we demonstrate that iron produces similar T1, T2, and T2* changes in the heart and liver using a gerbil iron-overload model. Methods and Results Twelve gerbils underwent iron dextran loading (200 mg · kg−1 · wk−1) from 2 to 14 weeks; 5 age-matched controls were studied as well. Animals had in vivo assessment of cardiac T2* and hepatic T2 and T2* and postmortem assessment of cardiac and hepatic T1 and T2. Relaxation measurements were performed in a clinical 1.5-T magnet and a 60-MHz nuclear magnetic resonance relaxometer. Cardiac and liver iron concentrations rose linearly with administered dose. Cardiac 1/T2*, 1/T2, and 1/T1 rose linearly with cardiac iron concentration. Liver 1/T2*, 1/T2, and 1/T1 also rose linearly, proportional to hepatic iron concentration. Liver and heart calibrations were similar on a dry-weight basis. Conclusions MRI measurements of cardiac T2 and T2* can be used to quantify cardiac iron. The similarity of liver and cardiac iron calibration curves in the gerbil suggests that extrapolation of human liver calibration curves to heart may be a rational approximation in humans. PMID:16027257

  17. Uncivilizing "Mental Illness": Contextualizing Diverse Mental States and Posthuman Emotional Ecologies within The Icarus Project.

    PubMed

    Fletcher, Erica Hua

    2018-03-01

    This article argues humans should not be defined strictly at their physical boundaries with clear distinctions between anatomical bodies, mental states, and the rest of the world. Rather, diverse mental states, which are often diagnosed as "mental illness," take shape within greater environmental forces and flows, including those that are constructed online. Drawing from a multi-sited ethnography of The Icarus Project, a radical mental health community, the author situates online narratives written by two of its members within posthuman emotional ecologies in which the exchange of ideas online affects mental states in a profound way. These narratives can be seen as a new type of psychiatric resistance based in new technologies, one that "uncivilizes" mental illness by searching for alternative frameworks and metaphors to understand lived experiences with mental distress. This ethnographic perspective differs significantly from traditional bio-psychiatric models and interventions and can offer both patients and mental healthcare providers with an alternative language to frame mental health.

  18. 40 CFR 600.011-93 - Reference materials.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Standard Test Method for Heat of Combustion of Liquid Hydrocarbon Fuels by Bomb Calorimeter 600.113-93, 600... Hydrocarbon Fuels by Bomb Calorimeter, IBR approved for §§ 600.113-93, 600.510-93, 600.113-08, and 600.510-08...

  19. 50 CFR 600.227 - Lobbying.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Lobbying. 600.227 Section 600.227 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.227 Lobbying. (a) Council...

  20. 50 CFR 600.230 - Removal.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Removal. 600.230 Section 600.230 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.230 Removal. The Secretary...

  1. 50 CFR 600.134 - Stipends.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Stipends. 600.134 Section 600.134 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Regional Fishery Management Councils § 600.134...

  2. 50 CFR 600.710 - Permits.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Permits. 600.710 Section 600.710 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS General Provisions for Domestic Fisheries § 600.710...

  3. 50 CFR 600.517 - Allocations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Allocations. 600.517 Section 600.517 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.517 Allocations. The Secretary...

  4. 50 CFR 600.230 - Removal.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Removal. 600.230 Section 600.230 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.230 Removal. The Secretary...

  5. 50 CFR 600.134 - Stipends.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Stipends. 600.134 Section 600.134 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Regional Fishery Management Councils § 600.134...

  6. 50 CFR 600.746 - Observers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Observers. 600.746 Section 600.746 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS General Provisions for Domestic Fisheries § 600.746...

  7. 50 CFR 600.134 - Stipends.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Stipends. 600.134 Section 600.134 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Regional Fishery Management Councils § 600.134...

  8. 50 CFR 600.735 - Penalties.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Penalties. 600.735 Section 600.735 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS General Provisions for Domestic Fisheries § 600.735...

  9. 50 CFR 600.227 - Lobbying.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Lobbying. 600.227 Section 600.227 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.227 Lobbying. (a) Council...

  10. 50 CFR 600.1016 - Enforcement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Enforcement. 600.1016 Section 600.1016 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Fishing Capacity Reduction Framework § 600.1016...

  11. 50 CFR 600.1016 - Enforcement.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Enforcement. 600.1016 Section 600.1016 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Fishing Capacity Reduction Framework § 600.1016...

  12. 44 CFR 17.600 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Purpose. 17.600 Section 17.600 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) § 17.600 Purpose. (a) The...

  13. 40 CFR 600.003 - Abbreviations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 31 2013-07-01 2013-07-01 false Abbreviations. 600.003 Section 600.003 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES General Provisions § 600.003 Abbreviations. The...

  14. 40 CFR 600.003 - Abbreviations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Abbreviations. 600.003 Section 600.003 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES General Provisions § 600.003 Abbreviations. The...

  15. 40 CFR 600.003 - Abbreviations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Abbreviations. 600.003 Section 600.003 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES General Provisions § 600.003 Abbreviations. The...

  16. The attentional blink is not affected by backward masking of T2, T2-mask SOA, or level of T2 impoverishment.

    PubMed

    Jannati, Ali; Spalek, Thomas M; Lagroix, Hayley E P; Di Lollo, Vincent

    2012-02-01

    Identification of the second of two targets (T2) is impaired when presented shortly after the first (T1). This attentional blink (AB) is thought to arise from a delay in T2 processing during which T2 is vulnerable to masking. Conventional studies have measured T2 accuracy which is constrained by the 100% ceiling. We avoided this problem by using a dynamic threshold-tracking procedure that is inherently free from ceiling constraints. In two experiments we examined how AB magnitude is affected by three masking-related factors: (a) presence/absence of T2 mask, (b) T2-mask stimulus onset asynchrony (SOA), and (c) level of T2 impoverishment (signal-to-noise ratio [SNR]). In Experiment 1, overall accuracy decreased with T2-mask SOA. The magnitude of the AB, however, was invariant with SOA and with mask presence/absence. Experiment 2 further showed that the AB was invariant with T2 SNR. The relationship among mask presence/absence, SOA, and T2 SNR and the AB is encompassed in a qualitative model.

  17. 76 FR 19724 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-08

    ... B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R Variant F Airplanes (Collectively... F4-605R and F4-622R airplanes, and Model A300 C4-605R Variant F airplanes; and Model A310-203, -204...

  18. 50 CFR 600.505 - Prohibitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Prohibitions. 600.505 Section 600.505 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.505 Prohibitions. (a) It is...

  19. 34 CFR 600.52 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Definitions. 600.52 Section 600.52 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION...) Programs § 600.52 Definitions. The following definitions apply to this subpart E: Foreign graduate medical...

  20. Experimental investigation of the solubility of albite and jadeite in H 2O, with paragonite + quartz at 500 and 600 °C, and 1-2.25 GPa

    NASA Astrophysics Data System (ADS)

    Wohlers, Anke; Manning, Craig E.; Thompson, Alan B.

    2011-05-01

    The solubilities of the assemblages albite + paragonite + quartz and jadeite + paragonite + quartz in H 2O were determined at 500 and 600 °C, 1.0-2.25 GPa, using hydrothermal piston-cylinder methods. The three minerals are isobarically and isothermally invariant in the presence of H 2O, so fluid composition is uniquely determined at each pressure and temperature. A phase-bracketing approach was used to achieve accurate solubility determinations. Albite + quartz and jadeite + quartz dissolve incongruently in H 2O, yielding residual paragonite which could not be retrieved and weighed. Solution composition fixed by the three-mineral assemblage at a given pressure and temperature was therefore bracketed by adding NaSi 3O 6.5 glass in successive experiments, until no paragonite was observed in run products. Solubilities derived from experiments bounding the appearance of paragonite thus constrain the equilibrium fluid composition. Results indicate that, at a given pressure, Na, Al, and Si concentrations are higher at 600 °C than at 500 °C. At both 500 and 600 °C, solubilities of all three elements increase with pressure in the albite stability field, to a maximum at the jadeite-albite-quartz equilibrium. In the jadeite stability field, element concentrations decline with continued pressure increase. At the solubility maximum, Na, Al, and Si concentrations are, respectively, 0.16, 0.05, and 0.48 molal at 500 °C, and 0.45, 0.27, and 1.56 molal at 600 °C. Bulk solubilities are 3.3 and 10.3 wt% oxides, respectively. Observed element concentrations are everywhere greater than those predicted from extrapolated thermodynamic data for simple ions, monomers, ion pairs, and the silica dimer. The measurements therefore require the presence of additional, polymerized Na-Al-Si-bearing species in the solutions. The excess solubility is >50% at all conditions, indicating that polymeric structures are the predominant solutes in the P- T region studied. The solubility patterns

  1. The spatial distribution of water in the inner coma of Comet 9P/Tempel 1: Comparison between models and observations

    NASA Astrophysics Data System (ADS)

    Finklenburg, S.; Thomas, N.; Su, C. C.; Wu, J.-S.

    2014-07-01

    The near nucleus coma of Comet 9P/Tempel 1 has been simulated with the 3D Direct Simulation Monte Carlo (DSMC) code PDSC++ (Su, C.-C. [2013]. Parallel Direct Simulation Monte Carlo (DSMC) Methods for Modeling Rarefied Gas Dynamics. PhD Thesis, National Chiao Tung University, Taiwan) and the derived column densities have been compared to observations of the water vapour distribution found by using infrared imaging spectrometer on the Deep Impact spacecraft (Feaga, L.M., A’Hearn, M.F., Sunshine, J.M., Groussin, O., Farnham, T.L. [2007]. Icarus 191(2), 134-145. http://dx.doi.org/10.1016/j.icarus.2007.04.038). Modelled total production rates are also compared to various observations made at the time of the Deep Impact encounter. Three different models were tested. For all models, the shape model constructed from the Deep Impact observations by Thomas et al. (Thomas, P.C., Veverka, J., Belton, M.J.S., Hidy, A., A’Hearn, M.F., Farnham, T.L., et al. [2007]. Icarus, 187(1), 4-15. http://dx.doi.org/10.1016/j.icarus.2006.12.013) was used. Outgassing depending only on the cosine of the solar insolation angle on each shape model facet is shown to provide an unsatisfactory model. Models constructed on the basis of active areas suggested by Kossacki and Szutowicz (Kossacki, K., Szutowicz, S. [2008]. Icarus, 195(2), 705-724. http://dx.doi.org/10.1016/j.icarus.2007.12.014) are shown to be superior. The Kossacki and Szutowicz model, however, also shows deficits which we have sought to improve upon. For the best model we investigate the properties of the outflow.

  2. [Role of CRISPR/Cas systems in drugresistance and virulence and the effect of IS600 on the expression of cse2 in Shigella].

    PubMed

    Hong, Lijuan; Zhang, Bing; Duan, Guangcai; Liang, Wenjuan; Wang, Yingfang; Chen, Shuaiyin; Yang, Haiyan; Xi, Yuanlin

    2016-12-04

    To analyze the relationship between CRISPR/Cas system and drug-resistance, virulence. To investigate the effect of IS600 on the expression of CRISPR associated gene cse2 in Shigella. CRISPR loci, CRISPR associated gene cse2, drug-resistant genes and virulent genes were detected by PCR in 33 Shigella strains; Trypan Blue counting test was used to detect bacterial virulence; Real-time PCR was used to detect relative mRNA expression of cse2; susceptibilities of Shigella strains were tested by agar diffusion method. Furthermore, we analyzed the relationship between CRISPR loci and drug-resistant genes, virulent genes. The effect of the IS600 on the expression of CRISPR associated gene cse2 was investigated. The mortality of Hela cells infected by Shigella with CRISPR1 loci was significantly lower (P<0.05) than those infected by Shigella without CRISPR1. The mRNA expression level of cse2 in group with IS600 was significantly (P<0.05) lower than that in group without IS600. CRISPR loci were widely present in Shigella. Shigella without CRISPR1 has a higher pathogenicity. Due to the insertion of IS600, the mRNA expression level of cse2 was decreased in Shigella.

  3. 24 CFR 598.600 - Applicability.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 3 2012-04-01 2012-04-01 false Applicability. 598.600 Section 598.600 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... Grants § 598.600 Applicability. This subpart applies to a project or activity proposed by an Empowerment...

  4. 24 CFR 598.600 - Applicability.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 3 2014-04-01 2013-04-01 true Applicability. 598.600 Section 598.600 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... Grants § 598.600 Applicability. This subpart applies to a project or activity proposed by an Empowerment...

  5. 24 CFR 598.600 - Applicability.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 3 2013-04-01 2013-04-01 false Applicability. 598.600 Section 598.600 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... Grants § 598.600 Applicability. This subpart applies to a project or activity proposed by an Empowerment...

  6. 7 CFR 25.600 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Purpose. 25.600 Section 25.600 Agriculture Office of the Secretary of Agriculture RURAL EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES Round II and Round IIS Grants § 25.600 Purpose. This subpart outlines USDA policies and authorizations and contains procedures...

  7. 7 CFR 25.600 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Purpose. 25.600 Section 25.600 Agriculture Office of the Secretary of Agriculture RURAL EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES Round II and Round IIS Grants § 25.600 Purpose. This subpart outlines USDA policies and authorizations and contains procedures...

  8. 7 CFR 25.600 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 1 2014-01-01 2014-01-01 false Purpose. 25.600 Section 25.600 Agriculture Office of the Secretary of Agriculture RURAL EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES Round II and Round IIS Grants § 25.600 Purpose. This subpart outlines USDA policies and authorizations and contains procedures...

  9. 7 CFR 25.600 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Purpose. 25.600 Section 25.600 Agriculture Office of the Secretary of Agriculture RURAL EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES Round II and Round IIS Grants § 25.600 Purpose. This subpart outlines USDA policies and authorizations and contains procedures...

  10. 7 CFR 25.600 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Purpose. 25.600 Section 25.600 Agriculture Office of the Secretary of Agriculture RURAL EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES Round II and Round IIS Grants § 25.600 Purpose. This subpart outlines USDA policies and authorizations and contains procedures...

  11. Preparation, characterization and luminescence properties of core-shell ternary terbium composites SiO2(600)@Tb(MABA-Si)•L

    NASA Astrophysics Data System (ADS)

    Ma, Yang-Yang; Li, Wen-Xian; Zheng, Yu-Shan; Bao, Jin-Rong; Li, Yi-Lian; Feng, Li-Na; Yang, Kui-Suo; Qiao, Yan; Wu, An-Ping

    2018-03-01

    Two novel core-shell structure ternary terbium composites SiO2(600)@Tb(MABA-Si)·L(L:dipy/phen) nanometre luminescence materials were prepared by ternary terbium complexes Tb(MABA-Si)·L2·(ClO4)3·2H2O shell grafted onto the surface of SiO2 microspheres. And corresponding ternary terbium complexes were synthesized using (CONH(CH2)3Si(OCH2CH3)3)2 (denoted as MABA-Si) as first ligand and L as second ligand coordinated with terbium perchlorate. The as-synthesized products were characterized by means of IR spectra, 1HNMR, element analysis, molar conductivity, SEM and TEM. It was found that the first ligand MABA-Si of terbium ternary complex hydrolysed to generate the Si-OH and the Si-OH condensate with the Si-OH on the surface of SiO2 microspheres; then ligand MABA-Si grafted onto the surface of SiO2 microspheres. The diameter of SiO2 core of SiO2(600)@Tb(MABA-Si)·L was approximately 600 nm. Interestingly, the luminescence properties demonstrate that the two core-shell structure ternary terbium composites SiO2(600)Tb(MABA-Si)·L(dipy/phen) exhibit strong emission intensities, which are 2.49 and 3.35 times higher than that of the corresponding complexes Tb(MABA-Si)·L2·(ClO4)3·2H2O, respectively. Luminescence decay curves show that core-shell structure ternary terbium composites have longer lifetime. Excellent luminescence properties enable the core-shell materials to have potential applications in medicine, industry, luminescent fibres and various biomaterials fields.

  12. Preparation, characterization and luminescence properties of core-shell ternary terbium composites SiO2(600)@Tb(MABA-Si)•L.

    PubMed

    Ma, Yang-Yang; Li, Wen-Xian; Zheng, Yu-Shan; Bao, Jin-Rong; Li, Yi-Lian; Feng, Li-Na; Yang, Kui-Suo; Qiao, Yan; Wu, An-Ping

    2018-03-01

    Two novel core-shell structure ternary terbium composites SiO 2(600) @Tb(MABA-Si)·L(L:dipy/phen) nanometre luminescence materials were prepared by ternary terbium complexes Tb(MABA-Si)·L 2 ·(ClO 4 ) 3 ·2H 2 O shell grafted onto the surface of SiO 2 microspheres. And corresponding ternary terbium complexes were synthesized using (CONH(CH 2 ) 3 Si(OCH 2 CH 3 ) 3 ) 2 (denoted as MABA-Si) as first ligand and L as second ligand coordinated with terbium perchlorate. The as-synthesized products were characterized by means of IR spectra, 1 HNMR, element analysis, molar conductivity, SEM and TEM. It was found that the first ligand MABA-Si of terbium ternary complex hydrolysed to generate the Si-OH and the Si-OH condensate with the Si-OH on the surface of SiO 2 microspheres; then ligand MABA-Si grafted onto the surface of SiO 2 microspheres. The diameter of SiO 2 core of SiO 2(600) @Tb(MABA-Si)·L was approximately 600 nm. Interestingly, the luminescence properties demonstrate that the two core-shell structure ternary terbium composites SiO 2(600) Tb(MABA-Si)·L(dipy/phen) exhibit strong emission intensities, which are 2.49 and 3.35 times higher than that of the corresponding complexes Tb(MABA-Si)·L 2 ·(ClO 4 ) 3 ·2H 2 O, respectively. Luminescence decay curves show that core-shell structure ternary terbium composites have longer lifetime. Excellent luminescence properties enable the core-shell materials to have potential applications in medicine, industry, luminescent fibres and various biomaterials fields.

  13. Preparation, characterization and luminescence properties of core–shell ternary terbium composites SiO2(600)@Tb(MABA-Si)•L

    PubMed Central

    Ma, Yang-Yang; Zheng, Yu-Shan; Bao, Jin-Rong; Li, Yi-Lian; Feng, Li-Na; Yang, Kui-Suo; Qiao, Yan; Wu, An-Ping

    2018-01-01

    Two novel core–shell structure ternary terbium composites SiO2(600)@Tb(MABA-Si)·L(L:dipy/phen) nanometre luminescence materials were prepared by ternary terbium complexes Tb(MABA-Si)·L2·(ClO4)3·2H2O shell grafted onto the surface of SiO2 microspheres. And corresponding ternary terbium complexes were synthesized using (CONH(CH2)3Si(OCH2CH3)3)2 (denoted as MABA-Si) as first ligand and L as second ligand coordinated with terbium perchlorate. The as-synthesized products were characterized by means of IR spectra, 1HNMR, element analysis, molar conductivity, SEM and TEM. It was found that the first ligand MABA-Si of terbium ternary complex hydrolysed to generate the Si–OH and the Si–OH condensate with the Si–OH on the surface of SiO2 microspheres; then ligand MABA-Si grafted onto the surface of SiO2 microspheres. The diameter of SiO2 core of SiO2(600)@Tb(MABA-Si)·L was approximately 600 nm. Interestingly, the luminescence properties demonstrate that the two core–shell structure ternary terbium composites SiO2(600)Tb(MABA-Si)·L(dipy/phen) exhibit strong emission intensities, which are 2.49 and 3.35 times higher than that of the corresponding complexes Tb(MABA-Si)·L2·(ClO4)3·2H2O, respectively. Luminescence decay curves show that core–shell structure ternary terbium composites have longer lifetime. Excellent luminescence properties enable the core–shell materials to have potential applications in medicine, industry, luminescent fibres and various biomaterials fields. PMID:29657773

  14. 76 FR 441 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-05

    ... Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R...-622, B4-605R, B4-622R, F4-605R, F4-622R, and C4-605R Variant F airplanes, certificated in any category...

  15. 21 CFR 600.90 - Waivers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Waivers. 600.90 Section 600.90 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL PRODUCTS: GENERAL Reporting of Adverse Experiences § 600.90 Waivers. (a) A licensed manufacturer may ask...

  16. 10 CFR 600.143 - Competition.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Competition. 600.143 Section 600.143 Energy DEPARTMENT OF... Nonprofit Organizations Post-Award Requirements § 600.143 Competition. All procurement transactions shall be conducted in a manner to provide, to the maximum extent practical, open and free competition. The recipient...

  17. 10 CFR 600.306 - Metric system of measurement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Metric system of measurement. 600.306 Section 600.306... system of measurement. (a) The Metric Conversion Act of 1975, as amended by the Omnibus Trade and... system is the preferred measurement system for U.S. trade and commerce. (2) The metric system of...

  18. 10 CFR 600.306 - Metric system of measurement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Metric system of measurement. 600.306 Section 600.306... system of measurement. (a) The Metric Conversion Act of 1975, as amended by the Omnibus Trade and... system is the preferred measurement system for U.S. trade and commerce. (2) The metric system of...

  19. 10 CFR 600.306 - Metric system of measurement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Metric system of measurement. 600.306 Section 600.306... system of measurement. (a) The Metric Conversion Act of 1975, as amended by the Omnibus Trade and... system is the preferred measurement system for U.S. trade and commerce. (2) The metric system of...

  20. 10 CFR 600.306 - Metric system of measurement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Metric system of measurement. 600.306 Section 600.306... system of measurement. (a) The Metric Conversion Act of 1975, as amended by the Omnibus Trade and... system is the preferred measurement system for U.S. trade and commerce. (2) The metric system of...

  1. 10 CFR 600.306 - Metric system of measurement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Metric system of measurement. 600.306 Section 600.306... system of measurement. (a) The Metric Conversion Act of 1975, as amended by the Omnibus Trade and... system is the preferred measurement system for U.S. trade and commerce. (2) The metric system of...

  2. 75 FR 76926 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-10

    ... Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R... airplanes; Model A300 B4-605R and B4-622R airplanes; Model A300 F4-605R and F4-622R airplanes; Model A300 C4...

  3. 75 FR 27956 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-19

    ... B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R Variant F Airplanes (Collectively...-203, and B4-203 airplanes; Model A300 B4-601, B4- 603, B4-620, B4-622, B4-605R, B4-622R, F4-605R, F4...

  4. 40 CFR 600.010-86 - Vehicle test requirements and minimum data requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... base level, and (iii) For additional model types established under § 600.207(a)(2), data from each... data requirements. 600.010-86 Section 600.010-86 Protection of Environment ENVIRONMENTAL PROTECTION... Provisions § 600.010-86 Vehicle test requirements and minimum data requirements. (a) For each certification...

  5. Frequent eruptions of Mount Rainier over the last ˜2,600 years

    NASA Astrophysics Data System (ADS)

    Sisson, T. W.; Vallance, J. W.

    2009-08-01

    Field, geochronologic, and geochemical evidence from proximal fine-grained tephras, and from limited exposures of Holocene lava flows and a small pyroclastic flow document ten-12 eruptions of Mount Rainier over the last 2,600 years, contrasting with previously published evidence for only 11-12 eruptions of the volcano for all of the Holocene. Except for the pumiceous subplinian C event of 2,200 cal year BP, the late-Holocene eruptions were weakly explosive, involving lava effusions and at least two block-and-ash pyroclastic flows. Eruptions were clustered from ˜2,600 to ˜2,200 cal year BP, an interval referred to as the Summerland eruptive period that includes the youngest lava effusion from the volcano. Thin, fine-grained tephras are the only known primary volcanic products from eruptions near 1,500 and 1,000 cal year BP, but these and earlier eruptions were penecontemporaneous with far-traveled lahars, probably created from newly erupted materials melting snow and glacial ice. The most recent magmatic eruption of Mount Rainier, documented geochemically, was the 1,000 cal year BP event. Products from a proposed eruption of Mount Rainier between AD 1820 and 1854 (X tephra of Mullineaux (US Geol Surv Bull 1326:1-83, 1974)) are redeposited C tephra, probably transported onto young moraines by snow avalanches, and do not record a nineteenth century eruption. We found no conclusive evidence for an eruption associated with the clay-rich Electron Mudflow of ˜500 cal year BP, and though rare, non-eruptive collapse of unstable edifice flanks remains as a potential hazard from Mount Rainier.

  6. Frequent eruptions of Mount Rainier over the last ∼2,600 years

    USGS Publications Warehouse

    Sisson, T.W.; Vallance, J.W.

    2009-01-01

    Field, geochronologic, and geochemical evidence from proximal fine-grained tephras, and from limited exposures of Holocene lava flows and a small pyroclastic flow document ten–12 eruptions of Mount Rainier over the last 2,600 years, contrasting with previously published evidence for only 11–12 eruptions of the volcano for all of the Holocene. Except for the pumiceous subplinian C event of 2,200 cal year BP, the late-Holocene eruptions were weakly explosive, involving lava effusions and at least two block-and-ash pyroclastic flows. Eruptions were clustered from ∼2,600 to ∼2,200 cal year BP, an interval referred to as the Summerland eruptive period that includes the youngest lava effusion from the volcano. Thin, fine-grained tephras are the only known primary volcanic products from eruptions near 1,500 and 1,000 cal year BP, but these and earlier eruptions were penecontemporaneous with far-traveled lahars, probably created from newly erupted materials melting snow and glacial ice. The most recent magmatic eruption of Mount Rainier, documented geochemically, was the 1,000 cal year BP event. Products from a proposed eruption of Mount Rainier between AD 1820 and 1854 (X tephra of Mullineaux (US Geol Surv Bull 1326:1–83, 1974)) are redeposited C tephra, probably transported onto young moraines by snow avalanches, and do not record a nineteenth century eruption. We found no conclusive evidence for an eruption associated with the clay-rich Electron Mudflow of ∼500 cal year BP, and though rare, non-eruptive collapse of unstable edifice flanks remains as a potential hazard from Mount Rainier.

  7. 10 CFR 600.316 - Audits.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Audits. 600.316 Section 600.316 Energy DEPARTMENT OF... Grants and Cooperative Agreements With For-Profit Organizations Post-Award Requirements § 600.316 Audits. (a) Any recipient that expends $500,000 or more in a year under Federal awards must have an audit...

  8. 21 CFR 600.12 - Records.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Records. 600.12 Section 600.12 Food and Drugs FOOD... PRODUCTS: GENERAL Establishment Standards § 600.12 Records. (a) Maintenance of records. Records shall be... be traced by an inspector. Such records shall be legible and indelible, shall identify the person...

  9. 21 CFR 600.12 - Records.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 7 2012-04-01 2012-04-01 false Records. 600.12 Section 600.12 Food and Drugs FOOD... PRODUCTS: GENERAL Establishment Standards § 600.12 Records. (a) Maintenance of records. Records shall be... be traced by an inspector. Such records shall be legible and indelible, shall identify the person...

  10. 21 CFR 600.12 - Records.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... product upon notification by the Director, Center for Biologics Evaluation and Research or the Director... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Records. 600.12 Section 600.12 Food and Drugs FOOD... PRODUCTS: GENERAL Establishment Standards § 600.12 Records. (a) Maintenance of records. Records shall be...

  11. 21 CFR 600.12 - Records.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... product upon notification by the Director, Center for Biologics Evaluation and Research or the Director... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Records. 600.12 Section 600.12 Food and Drugs FOOD... PRODUCTS: GENERAL Establishment Standards § 600.12 Records. (a) Maintenance of records. Records shall be...

  12. Organo-Nitrogen Reactions on Jupiter

    NASA Astrophysics Data System (ADS)

    Lamothe, V. L.; Moses, J. I.

    2000-10-01

    Because the altitude regions for CH4 and NH3 photodissociation are physically separated from each other in the Jovian atmosphere, the possibility of forming organo-nitrogen compounds on Jupiter has been an uncertain problem [1,2,3,4,5]. Carbon- and nitrogen-bearing species do not interact significantly in laboratory experiments involving ultraviolet irradiation of CH4-NH3-H2 mixtures [6,7]. However, HCN and a variety of complex organo-nitrogen molecules are produced when methane in the above experiments is replaced by unsaturated hydrocarbons such as C2H2 or CH3C2H [8,9]. To determine the formation efficiency of organo-nitrogen compounds on Jupiter, we have added the reaction schemes proposed by [3,8,9] to a photochemical model of the Jovian troposphere and stratosphere. We find that HCN does not form in observable quantities unless a large tropospheric source of C2H2 exists (e.g., via lightning-induced chemistry, see [10]). Organo-nitrogen reactions are unlikely to be important on Jupiter --- chromophores are most likely due to inorganic compounds. References: [1] Strobel, D. F. (1973), J. Atmos. Sci. 30, 1205; [2] Kaye, J. A., and D. F. Strobel (1983a), Icarus\\ 55, 399; [3] Kaye, J. A., and D. F. Strobel (1983b), Icarus\\ 54, 417; [4] Tokunaga, A. T. et al./ (1981), Icarus\\ 48, 283; [5] Bézard, B. et al./ (1995), Icarus\\ 118, 384; [6] Raulin, F. et al. (1979), Icarus\\ 38, 358; [7] Ferris, J. P., and J. Y. Morimoto (1981), Icarus\\ 48, 118; [8] Ferris, J. P., and Y. Ishikawa (1988), J. Am. Chem. Soc. 110, 4306; [9] Ferris, J. et\\ al. (1992), Icarus\\ 95, 54; [10] Bétremieux, Y., and R. V. Yelle (1999), BAAS\\ 31, 1180.

  13. The Attentional Blink Is Not Affected by Backward Masking of T2, T2-Mask SOA, or Level of T2 Impoverishment

    ERIC Educational Resources Information Center

    Jannati, Ali; Spalek, Thomas M.; Lagroix, Hayley E. P.; Di Lollo, Vincent

    2012-01-01

    Identification of the second of two targets (T2) is impaired when presented shortly after the first (T1). This "attentional blink" (AB) is thought to arise from a delay in T2 processing during which T2 is vulnerable to masking. Conventional studies have measured T2 accuracy which is constrained by the 100% ceiling. We avoided this problem by using…

  14. T2-Weighted Liver MRI Using the MultiVane Technique at 3T: Comparison with Conventional T2-Weighted MRI

    PubMed Central

    Kang, Kyung A; Kim, EunJu; Jeong, Woo Kyoung; Choi, Dongil; Lee, Won Jae; Jung, Sin-Ho; Baek, Sun-Young

    2015-01-01

    Objective To assess the value of applying MultiVane to liver T2-weighted imaging (T2WI) compared with conventional T2WIs with emphasis on detection of focal liver lesions. Materials and Methods Seventy-eight patients (43 men and 35 women) with 86 hepatic lesions and 20 pancreatico-biliary diseases underwent MRI including T2WIs acquired using breath-hold (BH), respiratory-triggered (RT), and MultiVane technique at 3T. Two reviewers evaluated each T2WI with respect to artefacts, organ sharpness, and conspicuity of intrahepatic vessels, hilar duct, and main lesion using five-point scales, and made pairwise comparisons between T2WI sequences for these categories. Diagnostic accuracy (Az) and sensitivity for hepatic lesion detection were evaluated using alternative free-response receiver operating characteristic analysis. Results MultiVane T2WI was significantly better than BH-T2WI or RT-T2WI for organ sharpness and conspicuity of intrahepatic vessels and main lesion in both separate reviews and pairwise comparisons (p < 0.001). With regard to motion artefacts, MultiVane T2WI or BH-T2WI was better than RT-T2WI (p < 0.001). Conspicuity of hilar duct was better with BH-T2WI than with MultiVane T2WI (p = 0.030) or RT-T2WI (p < 0.001). For detection of 86 hepatic lesions, sensitivity (mean, 97.7%) of MultiVane T2WI was significantly higher than that of BH-T2WI (mean, 89.5%) (p = 0.008) or RT-T2WI (mean, 84.9%) (p = 0.001). Conclusion Applying the MultiVane technique to T2WI of the liver is a promising approach to improving image quality that results in increased detection of focal liver lesions compared with conventional T2WI. PMID:26357498

  15. 10 CFR 600.220 - Standards for financial management systems.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... financial reporting requirements of the grant or subgrant. (2) Accounting records. Grantees and subgrantees... 10 Energy 4 2010-01-01 2010-01-01 false Standards for financial management systems. 600.220 Section 600.220 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES...

  16. 10 CFR 600.161 - Termination.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Nonprofit Organizations Post-Award Requirements § 600.161 Termination. (a) Awards may be terminated in whole or in part only if paragraph (a) (1), (2) or (3) of this section apply. (1) By DOE, if a recipient materially fails to comply with the terms and conditions of an award. (2) By DOE with the consent of the...

  17. 10 CFR 600.161 - Termination.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Nonprofit Organizations Post-Award Requirements § 600.161 Termination. (a) Awards may be terminated in whole or in part only if paragraph (a) (1), (2) or (3) of this section apply. (1) By DOE, if a recipient materially fails to comply with the terms and conditions of an award. (2) By DOE with the consent of the...

  18. 10 CFR 600.161 - Termination.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Nonprofit Organizations Post-Award Requirements § 600.161 Termination. (a) Awards may be terminated in whole or in part only if paragraph (a) (1), (2) or (3) of this section apply. (1) By DOE, if a recipient materially fails to comply with the terms and conditions of an award. (2) By DOE with the consent of the...

  19. Shifted termination assay (STA) fragment analysis to detect BRAF V600 mutations in papillary thyroid carcinomas

    PubMed Central

    2013-01-01

    Background BRAF mutation is an important diagnostic and prognostic marker in patients with papillary thyroid carcinoma (PTC). To be applicable in clinical laboratories with limited equipment, diverse testing methods are required to detect BRAF mutation. Methods A shifted termination assay (STA) fragment analysis was used to detect common V600 BRAF mutations in 159 PTCs with DNAs extracted from formalin-fixed paraffin-embedded tumor tissue. The results of STA fragment analysis were compared to those of direct sequencing. Serial dilutions of BRAF mutant cell line (SNU-790) were used to calculate limit of detection (LOD). Results BRAF mutations were detected in 119 (74.8%) PTCs by STA fragment analysis. In direct sequencing, BRAF mutations were observed in 118 (74.2%) cases. The results of STA fragment analysis had high correlation with those of direct sequencing (p < 0.00001, κ = 0.98). The LOD of STA fragment analysis and direct sequencing was 6% and 12.5%, respectively. In PTCs with pT3/T4 stages, BRAF mutation was observed in 83.8% of cases. In pT1/T2 carcinomas, BRAF mutation was detected in 65.9% and this difference was statistically significant (p = 0.007). Moreover, BRAF mutation was more frequent in PTCs with extrathyroidal invasion than tumors without extrathyroidal invasion (84.7% versus 62.2%, p = 0.001). To prepare and run the reactions, direct sequencing required 450 minutes while STA fragment analysis needed 290 minutes. Conclusions STA fragment analysis is a simple and sensitive method to detect BRAF V600 mutations in formalin-fixed paraffin-embedded clinical samples. Virtual Slides The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/5684057089135749 PMID:23883275

  20. MEK-ERK inhibition potentiates WAY-600-induced anti-cancer efficiency in preclinical hepatocellular carcinoma (HCC) models

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang, Kaifeng, E-mail: kaifeng_wangdr@sina.com; Fan, Yaohua; Chen, Gongying

    The search for novel anti-hepatocellular carcinoma (HCC) agents is important. Mammalian target of rapamycin (mTOR) hyper-activation plays a pivotal role in promoting HCC tumorigenesis and chemoresistance. The current preclinical study evaluated the potential anti-HCC activity by a potent mTOR kinase inhibitor, WAY-600. We showed that WAY-600 inhibited survival and proliferation of HCC cell lines (HepG2 and Huh7) and primary human HCC cells. Caspase-dependent apoptosis was activated by WAY-600 in above HCC cells. Reversely, caspase inhibitors largely attenuated WAY-600's lethality against HCC cells. At the signaling level, WAY-600 blocked mTOR complex 1/2 (mTORC1/2) assemble and activation, yet activated MEK-ERK pathway inmore » HCC cells. MEK-ERK inhibitors, PD-98059 and MEK-162, or MEK1/2 shRNA significantly potentiated WAY-600's cytotoxicity in HCC cells. Further studies showed that WAY-600 intraperitoneal (i.p.) administration in nude mice inhibited p-AKT Ser-473 and displayed significant anti-cancer activity against HepG2 xenografts. Remarkably, co-administration of MEK-162 further potentiated WAY-600's anti-HCC activity in vivo. These preclinical results demonstrate the potent anti-HCC activity by WAY-600, either alone or with MEK-ERK inhibitors. -- Highlights: •WAY-600 inhibits HCC cell survival and proliferation in vitro. •WAY-600 activates caspase-dependent apoptosis in HCC cells. •WAY-600 blocks mTORC1/2 activation, but activates MEK-ERK in HCC cells. •MEK-ERK inhibitors or MEK1/2 shRNA enhances WAY-600's cytotoxicity against HCC cells. •MEK-162 co-administration potentiates WAY-600-induced the anti-HepG2 tumor efficacy.« less

  1. Comment on “Modeling of opposition effects with ensembles of clusters: Interplay of various scattering mechanisms” by Elena V. Petrova, Victor P. Tishkovets, Klaus Jockers, 2007 [Icarus 188, 233 245

    NASA Astrophysics Data System (ADS)

    Shkuratov, Yuriy G.; Zubko, Evgenij S.

    2008-04-01

    We show that the mechanism called "near-field effect" [e.g., Petrova, E.V., Tishkovets, V.P., Jockers, K., 2007. Icarus 188, 233-245], which is used to explain wide-phase-angle negative polarization branch observed for planetary regoliths and cometary comas, is not realistic as it contradicts laboratory experiments and results of modeling with discrete dipole approximation calculations.

  2. 10 CFR 600.152 - Financial reporting.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Financial reporting. 600.152 Section 600.152 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES Uniform Administrative... Nonprofit Organizations Post-Award Requirements § 600.152 Financial reporting. (a) The following forms or...

  3. 10 CFR 603.600 - Administrative matters.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Administrative matters. 603.600 Section 603.600 Energy... Affecting Participants' Financial, Property, and Purchasing Systems § 603.600 Administrative matters. This subpart addresses “systemic” administrative matters that place requirements on the operation of a...

  4. 10 CFR 603.600 - Administrative matters.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Administrative matters. 603.600 Section 603.600 Energy... Affecting Participants' Financial, Property, and Purchasing Systems § 603.600 Administrative matters. This subpart addresses “systemic” administrative matters that place requirements on the operation of a...

  5. 10 CFR 603.600 - Administrative matters.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Administrative matters. 603.600 Section 603.600 Energy... Affecting Participants' Financial, Property, and Purchasing Systems § 603.600 Administrative matters. This subpart addresses “systemic” administrative matters that place requirements on the operation of a...

  6. 10 CFR 603.600 - Administrative matters.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Administrative matters. 603.600 Section 603.600 Energy... Affecting Participants' Financial, Property, and Purchasing Systems § 603.600 Administrative matters. This subpart addresses “systemic” administrative matters that place requirements on the operation of a...

  7. 10 CFR 603.600 - Administrative matters.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Administrative matters. 603.600 Section 603.600 Energy... Affecting Participants' Financial, Property, and Purchasing Systems § 603.600 Administrative matters. This subpart addresses “systemic” administrative matters that place requirements on the operation of a...

  8. 50 CFR 600.110 - Intercouncil fisheries.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Intercouncil fisheries. 600.110 Section 600.110 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Regional Fishery Management Councils § 600...

  9. 50 CFR 600.509 - Prohibited species.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Prohibited species. 600.509 Section 600.509 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.509 Prohibited...

  10. 50 CFR 600.110 - Intercouncil fisheries.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Intercouncil fisheries. 600.110 Section 600.110 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Regional Fishery Management Councils § 600...

  11. 50 CFR 600.513 - Recreational fishing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Recreational fishing. 600.513 Section 600.513 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.513 Recreational...

  12. 50 CFR 600.508 - Fishing operations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Fishing operations. 600.508 Section 600.508 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.508 Fishing...

  13. 50 CFR 600.235 - Financial disclosure.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Financial disclosure. 600.235 Section 600.235 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.235 Financial...

  14. 50 CFR 600.135 - Meeting procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Meeting procedures. 600.135 Section 600.135 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Regional Fishery Management Councils § 600...

  15. 50 CFR 600.135 - Meeting procedures.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Meeting procedures. 600.135 Section 600.135 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Regional Fishery Management Councils § 600...

  16. 10 CFR 600.141 - Recipient responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Nonprofit Organizations Post-Award Requirements § 600.141 Recipient responsibilities. The standards... contract(s). The recipient is the responsible authority, without recourse to DOE regarding the settlement... 10 Energy 4 2012-01-01 2012-01-01 false Recipient responsibilities. 600.141 Section 600.141 Energy...

  17. 10 CFR 600.141 - Recipient responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Nonprofit Organizations Post-Award Requirements § 600.141 Recipient responsibilities. The standards... contract(s). The recipient is the responsible authority, without recourse to DOE regarding the settlement... 10 Energy 4 2011-01-01 2011-01-01 false Recipient responsibilities. 600.141 Section 600.141 Energy...

  18. 10 CFR 600.141 - Recipient responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Nonprofit Organizations Post-Award Requirements § 600.141 Recipient responsibilities. The standards... contract(s). The recipient is the responsible authority, without recourse to DOE regarding the settlement... 10 Energy 4 2013-01-01 2013-01-01 false Recipient responsibilities. 600.141 Section 600.141 Energy...

  19. 10 CFR 600.141 - Recipient responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Nonprofit Organizations Post-Award Requirements § 600.141 Recipient responsibilities. The standards... contract(s). The recipient is the responsible authority, without recourse to DOE regarding the settlement... 10 Energy 4 2014-01-01 2014-01-01 false Recipient responsibilities. 600.141 Section 600.141 Energy...

  20. 40 CFR 600.001 - General applicability.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 31 2013-07-01 2013-07-01 false General applicability. 600.001 Section 600.001 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES General Provisions § 600.001 General...

  1. 40 CFR 600.001 - General applicability.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 31 2012-07-01 2012-07-01 false General applicability. 600.001 Section 600.001 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES General Provisions § 600.001 General...

  2. 40 CFR 600.301 - Labeling requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 31 2013-07-01 2013-07-01 false Labeling requirements. 600.301 Section 600.301 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Labeling § 600.301 Labeling...

  3. 40 CFR 600.301 - Labeling requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Labeling requirements. 600.301 Section 600.301 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Labeling § 600.301 Labeling...

  4. 40 CFR 600.301 - Labeling requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Labeling requirements. 600.301 Section 600.301 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Labeling § 600.301 Labeling...

  5. 40 CFR 600.001 - General applicability.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 30 2014-07-01 2014-07-01 false General applicability. 600.001 Section 600.001 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES General Provisions § 600.001 General...

  6. 10 CFR 600.152 - Financial reporting.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Financial reporting. 600.152 Section 600.152 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES Uniform Administrative... Nonprofit Organizations Post-Award Requirements § 600.152 Financial reporting. (a) The following forms or...

  7. New superhindered polydentate polyphosphine ligands P(CH2CH2P(t)Bu2)3, PhP(CH2CH2P(t)Bu2)2, P(CH2CH2CH2P(t)Bu2)3, and their ruthenium(II) chloride complexes.

    PubMed

    Gilbert-Wilson, Ryan; Field, Leslie D; Bhadbhade, Mohan M

    2012-03-05

    The synthesis and characterization of the extremely hindered phosphine ligands, P(CH(2)CH(2)P(t)Bu(2))(3) (P(2)P(3)(tBu), 1), PhP(CH(2)CH(2)P(t)Bu(2))(2) (PhP(2)P(2)(tBu), 2), and P(CH(2)CH(2)CH(2)P(t)Bu(2))(3) (P(3)P(3)(tBu), 3) are reported, along with the synthesis and characterization of ruthenium chloro complexes RuCl(2)(P(2)P(3)(tBu)) (4), RuCl(2)(PhP(2)P(2)(tBu)) (5), and RuCl(2)(P(3)P(3)(tBu)) (6). The bulky P(2)P(3)(tBu) (1) and P(3)P(3)(tBu) (3) ligands are the most sterically encumbered PP(3)-type ligands so far synthesized, and in all cases, only three phosphorus donors are able to bind to the metal center. Complexes RuCl(2)(PhP(2)P(2)(tBu)) (5) and RuCl(2)(P(3)P(3)(tBu)) (6) were characterized by crystallography. Low temperature solution and solid state (31)P{(1)H} NMR were used to demonstrate that the structure of RuCl(2)(P(2)P(3)(tBu)) (4) is probably analogous to that of RuCl(2)(PhP(2)P(2)(tBu)) (5) which had been structurally characterized.

  8. 10 CFR 600.132 - Real property.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Real property. 600.132 Section 600.132 Energy DEPARTMENT... Nonprofit Organizations Post-Award Requirements § 600.132 Real property. Unless otherwise provided by statute or program regulations, the requirements concerning the use and disposition of real property...

  9. 10 CFR 600.132 - Real property.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Real property. 600.132 Section 600.132 Energy DEPARTMENT... Nonprofit Organizations Post-Award Requirements § 600.132 Real property. Unless otherwise provided by statute or program regulations, the requirements concerning the use and disposition of real property...

  10. 10 CFR 600.132 - Real property.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Real property. 600.132 Section 600.132 Energy DEPARTMENT... Nonprofit Organizations Post-Award Requirements § 600.132 Real property. Unless otherwise provided by statute or program regulations, the requirements concerning the use and disposition of real property...

  11. 10 CFR 600.132 - Real property.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Real property. 600.132 Section 600.132 Energy DEPARTMENT... Nonprofit Organizations Post-Award Requirements § 600.132 Real property. Unless otherwise provided by statute or program regulations, the requirements concerning the use and disposition of real property...

  12. 14 CFR 1259.600 - Panel description.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Panel description. 1259.600 Section 1259.600 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NATIONAL SPACE GRANT COLLEGE AND FELLOWSHIP PROGRAM Space Grant Review Panel § 1259.600 Panel description. An independent committee...

  13. 50 CFR 600.513 - Recreational fishing.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Recreational fishing. 600.513 Section 600... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.513 Recreational fishing. (a) Foreign vessels conducting recreational fishing must comply only with this section, and...

  14. 50 CFR 600.513 - Recreational fishing.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Recreational fishing. 600.513 Section 600... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.513 Recreational fishing. (a) Foreign vessels conducting recreational fishing must comply only with this section, and...

  15. 50 CFR 600.513 - Recreational fishing.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Recreational fishing. 600.513 Section 600... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.513 Recreational fishing. (a) Foreign vessels conducting recreational fishing must comply only with this section, and...

  16. 50 CFR 600.513 - Recreational fishing.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Recreational fishing. 600.513 Section 600... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.513 Recreational fishing. (a) Foreign vessels conducting recreational fishing must comply only with this section, and...

  17. 50 CFR 600.240 - Security assurances.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Security assurances. 600.240 Section 600... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.240 Security assurances. (a) DOC Office of Security will issue security assurances to Council members following completion...

  18. 50 CFR 600.240 - Security assurances.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Security assurances. 600.240 Section 600... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.240 Security assurances. (a) DOC Office of Security will issue security assurances to Council members following completion...

  19. 50 CFR 600.240 - Security assurances.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Security assurances. 600.240 Section 600... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.240 Security assurances. (a) DOC Office of Security will issue security assurances to Council members following completion...

  20. 40 CFR 600.010-08 - Vehicle test requirements and minimum data requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., US06, SC03 and Cold temperature FTP data from each subconfiguration included within the model type. (2... data requirements. 600.010-08 Section 600.010-08 Protection of Environment ENVIRONMENTAL PROTECTION... Provisions § 600.010-08 Vehicle test requirements and minimum data requirements. (a) Unless otherwise...

  1. 40 CFR 600.010-86 - Vehicle test requirements and minimum data requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... additional model types established under § 600.207(a)(2), data from each subconfiguration included within the... data requirements. 600.010-86 Section 600.010-86 Protection of Environment ENVIRONMENTAL PROTECTION... requirements and minimum data requirements. (a) For each certification vehicle defined in this part, and for...

  2. 10 CFR 600.244 - Termination for convenience.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Termination for convenience. 600.244 Section 600.244 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES Uniform... Requirements § 600.244 Termination for convenience. Except as provided in § 600.443 awards may be terminated in...

  3. Preoperative detection of malignant liver tumors: Comparison of 3D-T2-weighted sequences with T2-weighted turbo spin-echo and single shot T2 at 1.5 T.

    PubMed

    Barat, Maxime; Soyer, Philippe; Dautry, Raphael; Pocard, Marc; Lo-Dico, Rea; Najah, Haythem; Eveno, Clarisse; Cassinotto, Christophe; Dohan, Anthony

    2018-03-01

    To assess the performances of three-dimensional (3D)-T2-weighted sequences compared to standard T2-weighted turbo spin echo (T2-TSE), T2-half-Fourier acquisition single-shot turbo spin-echo (T2-HASTE), diffusion weighted imaging (DWI) and 3D-T1-weighted VIBE sequences in the preoperative detection of malignant liver tumors. From 2012 to 2015, all patients of our institution undergoing magnetic resonance imaging (MRI) examination for suspected malignant liver tumors were prospectively included. Patients had contrast-enhanced 3D-T1-weighted, DWI, 3D-T2-SPACE, T2-HASTE and T2-TSE sequences. Imaging findings were compared with those obtained at follow-up, surgery and histopathological analysis. Sensitivities for the detection of malignant liver tumors were compared for each sequence using McNemar test. A subgroup analysis was conducted for HCCs. Image artifacts were analyzed and compared using Wilcoxon paired signed rank-test. Thirty-three patients were included: 13 patients had 40 hepatocellular carcinomas (HCC) and 20 had 54 liver metastases. 3D-T2-weighted sequences had a higher sensitivity than T2-weighted TSE sequences for the detection of malignant liver tumors (79.8% versus 68.1%; P < 0.001). The difference did not reach significance for HCC. T1-weighted VIBE and DWI had a higher sensitivity than T2-weighted sequences. 3D-T2-weighted-SPACE sequences showed significantly less artifacts than T2-weitghted TSE. 3D-T2-weighted sequences show very promising performances for the detection of liver malignant tumors compared to T2-weighted TSE sequences. Copyright © 2018 Elsevier B.V. All rights reserved.

  4. 10 CFR 600.148 - Contract provisions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Contract provisions. 600.148 Section 600.148 Energy... Nonprofit Organizations Post-Award Requirements § 600.148 Contract provisions. The recipient shall include... contracts. The following provisions shall also be applied to subcontracts. (a) Contracts in excess of the...

  5. 14 CFR 1259.600 - Panel description.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Panel description. 1259.600 Section 1259.600 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NATIONAL SPACE GRANT COLLEGE AND FELLOWSHIP PROGRAM Space Grant Review Panel § 1259.600 Panel description. An independent committee, the Space...

  6. 10 CFR 600.31 - Research misconduct.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Research misconduct. 600.31 Section 600.31 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES General § 600.31 Research misconduct. (a) A recipient is responsible for maintaining the integrity of research of any kind under an...

  7. 10 CFR 600.31 - Research misconduct.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Research misconduct. 600.31 Section 600.31 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES General § 600.31 Research misconduct. (a) A recipient is responsible for maintaining the integrity of research of any kind under an...

  8. 10 CFR 600.31 - Research misconduct.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Research misconduct. 600.31 Section 600.31 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES General § 600.31 Research misconduct. (a) A recipient is responsible for maintaining the integrity of research of any kind under an...

  9. 10 CFR 600.31 - Research misconduct.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Research misconduct. 600.31 Section 600.31 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES General § 600.31 Research misconduct. (a) A recipient is responsible for maintaining the integrity of research of any kind under an...

  10. 50 CFR 600.508 - Fishing operations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Fishing operations. 600.508 Section 600... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.508 Fishing.... fishing vessels. These joint venture operations with U.S. fishing vessels may be conducted throughout the...

  11. 50 CFR 600.508 - Fishing operations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Fishing operations. 600.508 Section 600... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.508 Fishing.... fishing vessels. These joint venture operations with U.S. fishing vessels may be conducted throughout the...

  12. 50 CFR 600.508 - Fishing operations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Fishing operations. 600.508 Section 600... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.508 Fishing.... fishing vessels. These joint venture operations with U.S. fishing vessels may be conducted throughout the...

  13. 50 CFR 600.508 - Fishing operations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Fishing operations. 600.508 Section 600... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.508 Fishing.... fishing vessels. These joint venture operations with U.S. fishing vessels may be conducted throughout the...

  14. 14 CFR 1212.600 - General policy.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true General policy. 1212.600 Section 1212.600 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PRIVACY ACT-NASA REGULATIONS Instructions for NASA Employees § 1212.600 General policy. In compliance with the Privacy Act and in accordance...

  15. 14 CFR 1212.600 - General policy.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false General policy. 1212.600 Section 1212.600 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PRIVACY ACT-NASA REGULATIONS Instructions for NASA Employees § 1212.600 General policy. In compliance with the Privacy Act and in accordance...

  16. 10 CFR 600.131 - Insurance coverage.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Insurance coverage. 600.131 Section 600.131 Energy... Nonprofit Organizations Post-Award Requirements § 600.131 Insurance coverage. Recipients shall, at a minimum, provide the equivalent insurance coverage for real property and equipment acquired with DOE funds as...

  17. 50 CFR 600.420 - Control system.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Control system. 600.420 Section 600.420..., DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Confidentiality of Statistics § 600.420 Control system. (a) The Assistant Administrator maintains a control system to protect the identity of submitters of...

  18. 50 CFR 600.420 - Control system.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Control system. 600.420 Section 600.420..., DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Confidentiality of Statistics § 600.420 Control system. (a) The Assistant Administrator maintains a control system to protect the identity of submitters of...

  19. 50 CFR 600.420 - Control system.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Control system. 600.420 Section 600.420..., DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Confidentiality of Statistics § 600.420 Control system. (a) The Assistant Administrator maintains a control system to protect the identity of submitters of...

  20. 50 CFR 600.420 - Control system.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Control system. 600.420 Section 600.420..., DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Confidentiality of Statistics § 600.420 Control system. (a) The Assistant Administrator maintains a control system to protect the identity of submitters of...

  1. 50 CFR 600.420 - Control system.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Control system. 600.420 Section 600.420..., DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Confidentiality of Statistics § 600.420 Control system. (a) The Assistant Administrator maintains a control system to protect the identity of submitters of...

  2. 7 CFR 600.5 - Area offices.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Area offices. 600.5 Section 600.5 Agriculture... AGRICULTURE GENERAL ORGANIZATION § 600.5 Area offices. Each area office is under the direction and supervision... for NRCS activities in the geographical area served by the area office. Usually the geographical area...

  3. 7 CFR 600.6 - Field offices.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Field offices. 600.6 Section 600.6 Agriculture... AGRICULTURE GENERAL ORGANIZATION § 600.6 Field offices. Each field office is under the direction and... served by the field office. Usually the geographical area of a field office includes one or more...

  4. 10 CFR 600.353 - Disputes and appeals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Disputes and appeals. 600.353 Section 600.353 Energy... Requirements for Grants and Cooperative Agreements With For-Profit Organizations Post-Award Requirements § 600.353 Disputes and appeals. Consistent with 10 CFR 600.22 and part 1024, recipients have the right to...

  5. 21 CFR 73.600 - Turmeric.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... ADDITIVES EXEMPT FROM CERTIFICATION Foods § 73.600 Turmeric. (a) Identity. (1) The color additive turmeric... purpose of identity as a color additive only, and shall not be construed as setting forth an official standard for turmeric under section 401 of the act. (2) Color additive mixtures made with turmeric may...

  6. 38 CFR 38.600 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Definitions. 38.600... evidence means that degree of proof which produces in the mind of the fact-finder a firm belief regarding...) [70 FR 4769, Jan. 31, 2005, as amended at 73 FR 35352, June 23, 2008] ...

  7. 38 CFR 38.600 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false Definitions. 38.600... evidence means that degree of proof which produces in the mind of the fact-finder a firm belief regarding...) [70 FR 4769, Jan. 31, 2005, as amended at 73 FR 35352, June 23, 2008] ...

  8. 38 CFR 38.600 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2014-07-01 2014-07-01 false Definitions. 38.600... evidence means that degree of proof which produces in the mind of the fact-finder a firm belief regarding...) [70 FR 4769, Jan. 31, 2005, as amended at 73 FR 35352, June 23, 2008] ...

  9. 38 CFR 38.600 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2013-07-01 2013-07-01 false Definitions. 38.600... evidence means that degree of proof which produces in the mind of the fact-finder a firm belief regarding...) [70 FR 4769, Jan. 31, 2005, as amended at 73 FR 35352, June 23, 2008] ...

  10. 38 CFR 38.600 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2012-07-01 2012-07-01 false Definitions. 38.600... evidence means that degree of proof which produces in the mind of the fact-finder a firm belief regarding...) [70 FR 4769, Jan. 31, 2005, as amended at 73 FR 35352, June 23, 2008] ...

  11. 50 CFR 600.506 - Observers.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Science and Research Director (see table 2 to § 600.502) may assign U.S. observers to FFV's. Except as... submit to the appropriate Regional Administrator or Science and Research Director and also to the Chief... date of arrival and expected date of departure. (1) The appropriate Regional Administrator or Science...

  12. 50 CFR 600.506 - Observers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Science and Research Director (see table 2 to § 600.502) may assign U.S. observers to FFV's. Except as... submit to the appropriate Regional Administrator or Science and Research Director and also to the Chief... date of arrival and expected date of departure. (1) The appropriate Regional Administrator or Science...

  13. 50 CFR 600.506 - Observers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Science and Research Director (see table 2 to § 600.502) may assign U.S. observers to FFV's. Except as... submit to the appropriate Regional Administrator or Science and Research Director and also to the Chief... date of arrival and expected date of departure. (1) The appropriate Regional Administrator or Science...

  14. 50 CFR 600.506 - Observers.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Science and Research Director (see table 2 to § 600.502) may assign U.S. observers to FFV's. Except as... submit to the appropriate Regional Administrator or Science and Research Director and also to the Chief... date of arrival and expected date of departure. (1) The appropriate Regional Administrator or Science...

  15. 50 CFR 600.506 - Observers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Science and Research Director (see table 2 to § 600.502) may assign U.S. observers to FFV's. Except as... submit to the appropriate Regional Administrator or Science and Research Director and also to the Chief... date of arrival and expected date of departure. (1) The appropriate Regional Administrator or Science...

  16. 10 CFR 600.124 - Program income.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Program income. 600.124 Section 600.124 Energy DEPARTMENT... Nonprofit Organizations Post-Award Requirements § 600.124 Program income. (a) The standards set forth in this section shall be used to account for program income related to projects financed in whole or in...

  17. 50 CFR 600.625 - Secretary's decision.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Secretary's decision. 600.625 Section 600... Section 306(b) § 600.625 Secretary's decision. (a) The Secretary will, on the basis of the hearing, record... for Federal preemption are determined to exist, the Secretary will notify in writing the Attorney...

  18. 50 CFR 600.625 - Secretary's decision.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Secretary's decision. 600.625 Section 600... Section 306(b) § 600.625 Secretary's decision. (a) The Secretary will, on the basis of the hearing, record... for Federal preemption are determined to exist, the Secretary will notify in writing the Attorney...

  19. 50 CFR 600.625 - Secretary's decision.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Secretary's decision. 600.625 Section 600... Section 306(b) § 600.625 Secretary's decision. (a) The Secretary will, on the basis of the hearing, record... for Federal preemption are determined to exist, the Secretary will notify in writing the Attorney...

  20. 7 CFR 600.4 - State offices.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false State offices. 600.4 Section 600.4 Agriculture... AGRICULTURE GENERAL ORGANIZATION § 600.4 State offices. Each office is under the direction and supervision of... Pacific Basin Area Office, under the direction and supervision of a director, serves the U.S. Trust...

  1. Treat-to-target (T2T) recommendations for gout.

    PubMed

    Kiltz, U; Smolen, J; Bardin, T; Cohen Solal, A; Dalbeth, N; Doherty, M; Engel, B; Flader, C; Kay, J; Matsuoka, M; Perez-Ruiz, F; da Rocha Castelar-Pinheiro, G; Saag, K; So, A; Vazquez Mellado, J; Weisman, M; Westhoff, T H; Yamanaka, H; Braun, J

    2017-04-01

    The treat-to-target (T2T) concept has been applied successfully in several inflammatory rheumatic diseases. Gout is a chronic disease with a high burden of pain and inflammation. Because the pathogenesis of gout is strongly related to serum urate levels, gout may be an ideal disease in which to apply a T2T approach. Our aim was to develop international T2T recommendations for patients with gout. A committee of experts with experience in gout agreed upon potential targets and outcomes, which was the basis for the systematic literature search. Eleven rheumatologists, one cardiologist, one nephrologist, one general practitioner and one patient met in October 2015 to develop T2T recommendations based on the available scientific evidence. Levels of evidence, strength of recommendations and levels of agreement were derived. Although no randomised trial was identified in which a comparison with standard treatment or an evaluation of a T2T approach had been performed in patients with gout, indirect evidence was provided to focus on targets such as normalisation of serum urate levels. The expert group developed four overarching principles and nine T2T recommendations. They considered dissolution of crystals and prevention of flares to be fundamental; patient education, ensuring adherence to medications and monitoring of serum urate levels were also considered to be of major importance. This is the first application of the T2T approach developed for gout. Since no publication reports a trial comparing treatment strategies for gout, highly credible overarching principles and level D expert recommendations were created and agreed upon. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  2. Microstructure investigations of U3Si2 implanted by high-energy Xe ions at 600 °C

    NASA Astrophysics Data System (ADS)

    Miao, Yinbin; Harp, Jason; Mo, Kun; Kim, Yeon Soo; Zhu, Shaofei; Yacout, Abdellatif M.

    2018-05-01

    The microstructure investigations on a high-energy Xe-implanted U3Si2 pellet were performed. The promising accident tolerant fuel (ATF) candidate, U3Si2, was irradiated by 84 MeV Xe ions at 600 °C at Argonne Tandem Linac Accelerator System (ATLAS). The characterizations of the Xe implanted sample were conducted using advanced transmission electron microscopy (TEM) techniques. An oxidation layer was observed on the sample surface after irradiation under the ∼10-5 Pa vacuum. The study on the oxidation layer not only unveils the readily oxidation behavior of U3Si2 under high-temperature irradiation conditions, but also develops an understanding of its oxidation mechanism. Intragranular Xe bubbles with bimodal size distribution were observed within the Xe deposition region of the sample induced by 84 MeV Xe ion implantation. At the irradiation temperature of 600 °C, the gaseous swelling strain contributed by intragranular bubbles was found to be insignificant, indicating an acceptable fission gas behavior of U3Si2 as a light water reactor (LWR) fuel operating at such a temperature.

  3. 46 CFR 181.600 - Fire axe.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Fire axe. 181.600 Section 181.600 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) FIRE PROTECTION EQUIPMENT Additional Equipment § 181.600 Fire axe. A vessel of more than 19.8 meters (65 feet) in length...

  4. The Effect of N2 Photoabsorption Cross Section Resolution on C2H6 Production in Titan’s Ionosphere

    NASA Astrophysics Data System (ADS)

    Luspay-Kuti, Adrienn; Mandt, Kathleen E.; Plessis, Sylvain; Greathouse, Thomas K.

    2014-11-01

    Titan’s rich organic chemistry begins with the photochemistry of only two molecules: N2 and CH4. The details on how higher-order hydrocarbons and nitriles are formed from these molecules have key implications for both the structure and evolution of Titan’s atmosphere, and for its surface-atmosphere interactions. Of high importance is the production of C2H6, which is a sink for CH4, and a main component in the polar lakes. Results of photochemical models, though, may be sensitive to the choice of input parameters, such as the N2 photoabsorption cross section resolution, as previously shown for nitrogen (Liang et al. (2007) ApJL 664, 115-118), and CH4 (Lavvas et al. (2011) Icarus 213, 233-251). Here we investigate the possibility of the same effect on the production rates of C2H6. We modeled production and loss rates, as well as mixing ratio and density profiles between an altitude of 600 and 1600 km for low and high resolution N2 cross sections via a coupled ion-neutral-thermal model (De La Haye et al. (2008) Icarus 197, 110-136; Mandt et al. (2012) JGR 117, E10006). Our results show a clear impact of photoabsorption cross section resolution used on all neutral and ion species contributing to C2H6 production. The magnitude of the influence varies amongst species. Ethane production profiles exhibit a significant increase with better resolution; a factor of 1.2 between 750 and 950 km, and a factor of 1.1 in the total column-integrated production rate. These values are lower limits, as additional reactions involving C2H5 not included in the model may also contribute to the production rates. The clear effect on C2H6 (which is not a parent molecule, nor does it bear nitrogen) may have important implications for other molecules in Titan’s atmosphere as well. The possible non-negligible impact of an isotope of nitrogen may argue for the inclusion of isotopes in photochemical models. For future analysis, development of a more efficient and streamlined model called

  5. 46 CFR 118.600 - Fire axe.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Fire axe. 118.600 Section 118.600 Shipping COAST GUARD... OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS FIRE PROTECTION EQUIPMENT Additional Equipment § 118.600 Fire axe. A vessel of more than 19.8 meters (65 feet) in length must have at least one fire axe...

  6. Lead effect on the corrosion and passivation behavior of Alloy 600

    NASA Astrophysics Data System (ADS)

    Zhou, Zhongquan

    2005-07-01

    Dissolved Pb is considered as the most aggressive chemical species involved in the initiation and growth of stress corrosion cracking (SCC) in a pressurized water reactor (PWR) power generating system. The results from laboratory studies indicate that Pb-induced SCC (PbSCC) covers a range of potential and pH which is the largest of all the submodes of SCC occurring in steam generators (SG) and it occurs at threshold concentrations as low as 0.1 ppm. It is hypothesized that PbSCC is caused by the incorporation of Pb into the passive film, which reduces the passivity of the film and enhances the selective dissolution of Ni from the base metal. This investigation is focused on studying the effect of Pb on the dissolution and passivation of Alloy 600 MA in order to provide information for understanding the PbSCC mechanism. The effect of Pb on Alloy 600 MA was investigated in the solutions containing 110ppm Cl- and different concentrations of Pb 2+ at 90°C with pH4.5. Potentiodynamic polarization scans, electrochemical impedance spectroscopy, Auger electron spectroscopy (AES) and X-ray photoelectron spectroscopy (XPS) were used to study the electrochemical behavior of Alloy 600 MA in the active and passive potential region in the solutions with/without Pb2+ in order to compare the effect of Pb on the dissolution and passivation of Alloy 600. The results indicated that the corrosion of Alloy 600 induced by Pb 2+ was ascribed to the enhanced dissolution of Ni by the reduction of Pb2+ at potentials slightly more cathodic than EPb2+/Pb0G Pb0=1 . The lower boundary of Pb2+ concentration for the occurrence of the displacement reaction is 2.5ppb according to thermodynamic calculations. The passivation of Alloy 600 was retarded by the Pb2+ and it was ascribed to the inhibited growth of NiO at passive potential and the increased conductivity of Cr2O3 by doping Pb 2+ in Cr2O3 lattice.

  7. Overexpression of ATP-Binding Cassette Transporter ABCG2 as a Potential Mechanism of Acquired Resistance to Vemurafenib in BRAF(V600E) Mutant Cancer Cells

    PubMed Central

    Wu, Chung-Pu; Sim, Hong-May; Huang, Yang-Hui; Liu, Yen-Chen; Hsiao, Sung-Han; Cheng, Hsing-Wen; Li, Yan-Qing; Ambudkar, Suresh V.; Hsu, Sheng-Chieh

    2012-01-01

    Melanoma is the most serious type of skin cancer with a high potential for metastasis and very low survival rates. The discovery of constitutive activation of the BRAF kinase caused by activating BRAF(V600E) kinase mutation in most melanoma patients led to the discovery of the first potent BRAF(V600E) signaling inhibitor, vemurafenib. Vemurafenib was effective in treating advanced melanoma patients and was proposed for the treatment of other BRAF(V600E) mutant cancers as well. Unfortunately, the success of vemurafenib was hampered by the rapid development of acquired resistance in different types of BRAF(V600E) mutant cancer cells. It becomes important to identify and evaluate all of the potential mechanisms of cellular resistance to vemurafenib. In this study, we characterized the interactions of vemurafenib with three major ATP-binding cassette (ABC) transporters, ABCB1, ABCC1 and ABCG2. We found that vemurafenib stimulated the ATPase activity and potently inhibited drug efflux mediated by ABCB1 and ABCG2. Vemurafenib also restored drug sensitivity in ABCG2-overexpressing cells. Moreover, we revealed that in the presence of functional ABCG2, BRAF kinase inhibition by vemurafenib is reduced in BRAF(V600E) mutant A375 cells. Taken together, our findings indicate that ABCG2 confers resistance to vemurafenib in A375 cells, suggesting involvement of this transporter in acquired resistance to vemurafenib. Thus, combination chemotherapy targeting multiple pathways could be an effective therapeutic strategy to overcome acquired resistance to vemurafenib for cancers harboring the BRAF(V600E) mutation. PMID:23153455

  8. 7 CFR 900.600 - General.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false General. 900.600 Section 900.600 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS Information...

  9. 7 CFR 900.600 - General.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false General. 900.600 Section 900.600 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS Information...

  10. 7 CFR 900.600 - General.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false General. 900.600 Section 900.600 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS Information...

  11. 7 CFR 900.600 - General.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false General. 900.600 Section 900.600 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS Information...

  12. Nonstandard neutrino interactions at DUNE, T2HK and T2HKK

    DOE PAGES

    Liao, Jiajun; Marfatia, Danny; Whisnant, Kerry

    2017-01-17

    Here, we study the matter effect caused by nonstandard neutrino interactions (NSI) in the next generation long-baseline neutrino experiments, DUNE, T2HK and T2HKK. If multiple NSI parameters are nonzero, the potential of these experiments to detect CP violation, determine the mass hierarchy and constrain NSI is severely impaired by degeneracies between the NSI parameters and by the generalized mass hierarchy degeneracy. In particular, a cancellation between leading order terms in the appearance channels when ϵ eτ= cot θ 23ϵ eμ, strongly affects the sensitivities to these two NSI parameters at T2HK and T2HKK. We also study the dependence of themore » sensitivities on the true CP phase and the true mass hierarchy, and find that overall DUNE has the best sensitivity to the magnitude of the NSI parameters, while T2HKK has the best sensitivity to CP violation whether or not there are NSI. Furthermore, for T2HKK a smaller off-axis angle for the Korean detector is better overall. We find that due to the structure of the leading order terms in the appearance channel probabilities, the NSI sensitivities in a given experiment are similar for both mass hierarchies, modulo the phase change δ→δ + 180°.« less

  13. Nonstandard neutrino interactions at DUNE, T2HK and T2HKK

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liao, Jiajun; Marfatia, Danny; Whisnant, Kerry

    Here, we study the matter effect caused by nonstandard neutrino interactions (NSI) in the next generation long-baseline neutrino experiments, DUNE, T2HK and T2HKK. If multiple NSI parameters are nonzero, the potential of these experiments to detect CP violation, determine the mass hierarchy and constrain NSI is severely impaired by degeneracies between the NSI parameters and by the generalized mass hierarchy degeneracy. In particular, a cancellation between leading order terms in the appearance channels when ϵ eτ= cot θ 23ϵ eμ, strongly affects the sensitivities to these two NSI parameters at T2HK and T2HKK. We also study the dependence of themore » sensitivities on the true CP phase and the true mass hierarchy, and find that overall DUNE has the best sensitivity to the magnitude of the NSI parameters, while T2HKK has the best sensitivity to CP violation whether or not there are NSI. Furthermore, for T2HKK a smaller off-axis angle for the Korean detector is better overall. We find that due to the structure of the leading order terms in the appearance channel probabilities, the NSI sensitivities in a given experiment are similar for both mass hierarchies, modulo the phase change δ→δ + 180°.« less

  14. Gaining insight into the T _2^*-T2 relationship in surface NMR free-induction decay measurements

    NASA Astrophysics Data System (ADS)

    Grombacher, Denys; Auken, Esben

    2018-05-01

    One of the primary shortcomings of the surface nuclear magnetic resonance (NMR) free-induction decay (FID) measurement is the uncertainty surrounding which mechanism controls the signal's time dependence. Ideally, the FID-estimated relaxation time T_2^* that describes the signal's decay carries an intimate link to the geometry of the pore space. In this limit the parameter T_2^* is closely linked to a related parameter T2, which is more closely linked to pore-geometry. If T_2^* ˜eq {T_2} the FID can provide valuable insight into relative pore-size and can be used to make quantitative permeability estimates. However, given only FID measurements it is difficult to determine whether T_2^* is linked to pore geometry or whether it has been strongly influenced by background magnetic field inhomogeneity. If the link between an observed T_2^* and the underlying T2 could be further constrained the utility of the standard surface NMR FID measurement would be greatly improved. We hypothesize that an approach employing an updated surface NMR forward model that solves the full Bloch equations with appropriately weighted relaxation terms can be used to help constrain the T_2^*-T2 relationship. Weighting the relaxation terms requires estimating the poorly constrained parameters T2 and T1; to deal with this uncertainty we propose to conduct a parameter search involving multiple inversions that employ a suite of forward models each describing a distinct but plausible T_2^*-T2 relationship. We hypothesize that forward models given poor T2 estimates will produce poor data fits when using the complex-inversion, while forward models given reliable T2 estimates will produce satisfactory data fits. By examining the data fits produced by the suite of plausible forward models, the likely T_2^*-T2 can be constrained by identifying the range of T2 estimates that produce reliable data fits. Synthetic and field results are presented to investigate the feasibility of the proposed technique.

  15. 38 CFR 0.600 - General.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ....600 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS VALUES, STANDARDS OF ETHICAL CONDUCT, AND RELATED RESPONSIBILITIES Core Values and Characteristics of the Department § 0.600 General. This section describes the Core Values and Characteristics that serve as internal guidelines for...

  16. 38 CFR 0.600 - General.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....600 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS VALUES, STANDARDS OF ETHICAL CONDUCT, AND RELATED RESPONSIBILITIES Core Values and Characteristics of the Department § 0.600 General. This section describes the Core Values and Characteristics that serve as internal guidelines for...

  17. 50 CFR 600.750 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Definitions. 600.750 Section 600.750 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION.... Consensus means unanimous concurrence among the members on a Fishery Negotiation Panel established under...

  18. 7 CFR 1220.600 - Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1220.600 Section 1220.600 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS..., Promotion, Research, and Consumer Information Act set forth in title XIX, subtitle E, of the Food...

  19. 13 CFR 130.600 - Cooperative agreement. [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Cooperative agreement. [Reserved] 130.600 Section 130.600 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS DEVELOPMENT CENTERS § 130.600 Cooperative agreement. [Reserved] ...

  20. 13 CFR 130.600 - Cooperative agreement. [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Cooperative agreement. [Reserved] 130.600 Section 130.600 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS DEVELOPMENT CENTERS § 130.600 Cooperative agreement. [Reserved] ...

  1. Rechargeable Li/Li(x)CoO(2) 100 Ah/600 Ah Battery With Integral Smart Charge Control

    DTIC Science & Technology

    1999-03-01

    Rechargeable Li/LixCo02100 Ah/600 Ah Battery with Integral Smart Charge Control By Charles J. Kelly ^ (Alliant Techsystems, Inc., Alliant Power...Rechargeable Li/LixCo02100 Ah/600 Ah Battery with Integral Smart Charge Control By Charles J. Kelly (Alliant Techsystems, Inc., Alliant Power Sources...AND SUBTITLE Rechargeable Li/LixCo02100 Ah/600 Ah Battery with Integral Smart Charge Control 6 AUTHOR(S) C. J. Kelly (Alliant Power Sources Co

  2. 31 CFR 1026.600 - General.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false General. 1026.600 Section 1026.600 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY RULES FOR FUTURES COMMISSION MERCHANTS AND INTRODUCING BROKERS...

  3. 31 CFR 1026.600 - General.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false General. 1026.600 Section 1026.600 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY RULES FOR FUTURES COMMISSION MERCHANTS AND INTRODUCING BROKERS...

  4. 31 CFR 1026.600 - General.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false General. 1026.600 Section 1026.600 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY RULES FOR FUTURES COMMISSION MERCHANTS AND INTRODUCING BROKERS...

  5. 31 CFR 1026.600 - General.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false General. 1026.600 Section 1026.600 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY RULES FOR FUTURES COMMISSION MERCHANTS AND INTRODUCING BROKERS...

  6. 31 CFR 1022.600 - General.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false General. 1022.600 Section 1022.600 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY RULES FOR MONEY SERVICES BUSINESSES Special Standards of...

  7. 31 CFR 1022.600 - General.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false General. 1022.600 Section 1022.600 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY RULES FOR MONEY SERVICES BUSINESSES Special Standards of...

  8. 31 CFR 1022.600 - General.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false General. 1022.600 Section 1022.600 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY RULES FOR MONEY SERVICES BUSINESSES Special Standards of...

  9. 31 CFR 1022.600 - General.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false General. 1022.600 Section 1022.600 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY RULES FOR MONEY SERVICES BUSINESSES Special Standards of...

  10. 24 CFR 960.600 - Implementation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Implementation. 960.600 Section 960.600 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT...

  11. 21 CFR 600.10 - Personnel.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Personnel. 600.10 Section 600.10 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL... manufacturing operations which they perform, the necessary training and experience relating to individual...

  12. 24 CFR 570.600 - General.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false General. 570.600 Section 570.600 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT...

  13. 13 CFR 120.600 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Definitions. 120.600 Section 120.600 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Secondary Market... listed in FTA's records. (k) SBA's Secondary Market Program Guide is an issuance from SBA which describes...

  14. 7 CFR 600.7 - Specialized field offices.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Specialized field offices. 600.7 Section 600.7..., DEPARTMENT OF AGRICULTURE GENERAL ORGANIZATION § 600.7 Specialized field offices. Other field offices serve... direction and supervision of these offices. ...

  15. A taxonomy of medical uncertainties in clinical genome sequencing.

    PubMed

    Han, Paul K J; Umstead, Kendall L; Bernhardt, Barbara A; Green, Robert C; Joffe, Steven; Koenig, Barbara; Krantz, Ian; Waterston, Leo B; Biesecker, Leslie G; Biesecker, Barbara B

    2017-08-01

    Clinical next-generation sequencing (CNGS) is introducing new opportunities and challenges into the practice of medicine. Simultaneously, these technologies are generating uncertainties of an unprecedented scale that laboratories, clinicians, and patients are required to address and manage. We describe in this report the conceptual design of a new taxonomy of uncertainties around the use of CNGS in health care. Interviews to delineate the dimensions of uncertainty in CNGS were conducted with genomics experts and themes were extracted in order to expand on a previously published three-dimensional taxonomy of medical uncertainty. In parallel, we developed an interactive website to disseminate the CNGS taxonomy to researchers and engage them in its continued refinement. The proposed taxonomy divides uncertainty along three axes-source, issue, and locus-and further discriminates the uncertainties into five layers with multiple domains. Using a hypothetical clinical example, we illustrate how the taxonomy can be applied to findings from CNGS and used to guide stakeholders through interpretation and implementation of variant results. The utility of the proposed taxonomy lies in promoting consistency in describing dimensions of uncertainty in publications and presentations, to facilitate research design and management of the uncertainties inherent in the implementation of CNGS.Genet Med advance online publication 19 January 2017.

  16. A Taxonomy of Medical Uncertainties in Clinical Genome Sequencing

    PubMed Central

    Han, Paul K. J.; Umstead, Kendall L.; Bernhardt, Barbara A.; Green, Robert C.; Joffe, Steven; Koenig, Barbara; Krantz, Ian; Waterston, Leo B.; Biesecker, Leslie G.; Biesecker, Barbara B.

    2017-01-01

    Purpose Clinical next generation sequencing (CNGS) is introducing new opportunities and challenges into the practice of medicine. Simultaneously, these technologies are generating uncertainties of unprecedented scale that laboratories, clinicians, and patients are required to address and manage. We describe in this report the conceptual design of a new taxonomy of uncertainties around the use of CNGS in health care. Methods Interviews to delineate the dimensions of uncertainty in CNGS were conducted with genomics experts, and themes were extracted in order to expand upon a previously published three-dimensional taxonomy of medical uncertainty. In parallel we developed an interactive website to disseminate the CNGS taxonomy to researchers and engage them in its continued refinement. Results The proposed taxonomy divides uncertainty along three axes: source, issue, and locus, and further discriminates the uncertainties into five layers with multiple domains. Using a hypothetical clinical example, we illustrate how the taxonomy can be applied to findings from CNGS and used to guide stakeholders through interpretation and implementation of variant results. Conclusion The utility of the proposed taxonomy lies in promoting consistency in describing dimensions of uncertainty in publications and presentations, to facilitate research design and management of the uncertainties inherent in the implementation of CNGS. PMID:28102863

  17. 40 CFR 35.600 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ASSISTANCE Environmental Program Grants for Tribes Water Quality Cooperative Agreements (section 104(b)(3)) § 35.600 Purpose. (a) Purpose of section. Sections 35.600 through 35.604 govern Water Quality... Water Act. These sections do not govern Water Quality Cooperative Agreements under section 104(b)(3) to...

  18. 46 CFR 199.600 - General.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false General. 199.600 Section 199.600 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LIFESAVING APPLIANCES AND ARRANGEMENTS LIFESAVING SYSTEMS FOR.... This subpart sets out specific exemptions and alternatives to requirements in subparts A, B, C, D, and...

  19. 38 CFR 17.600 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Purpose. 17.600 Section 17.600 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Va Health... Scholarship Program to students receiving education or training in a direct or indirect health-care services...

  20. 45 CFR 153.600 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false [Reserved] 153.600 Section 153.600 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS STANDARDS RELATED TO REINSURANCE, RISK CORRIDORS, AND RISK ADJUSTMENT UNDER THE AFFORDABLE CARE ACT Health Insurance Issuer...

  1. 45 CFR 153.600 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false [Reserved] 153.600 Section 153.600 Public Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE ACCESS STANDARDS RELATED TO REINSURANCE, RISK CORRIDORS, AND RISK ADJUSTMENT UNDER THE AFFORDABLE CARE ACT Health Insurance Issuer...

  2. 45 CFR 153.600 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false [Reserved] 153.600 Section 153.600 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS STANDARDS RELATED TO REINSURANCE, RISK CORRIDORS, AND RISK ADJUSTMENT UNDER THE AFFORDABLE CARE ACT Health Insurance Issuer...

  3. 10 CFR 600.230 - Changes.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Changes. 600.230 Section 600.230 Energy DEPARTMENT OF... Changes. (a) General. Grantees and subgrantees are permitted to rebudget within the approved direct cost budget to meet unanticipated requirements and may make limited program changes to the approved project...

  4. 50 CFR 600.245 - Council member compensation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Council member compensation. 600.245 Section 600.245 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600...

  5. 10 CFR 600.137 - Property trust relationship.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Property trust relationship. 600.137 Section 600.137 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES Uniform..., Hospitals, and Other Nonprofit Organizations Post-Award Requirements § 600.137 Property trust relationship...

  6. BRAFV600E mutation in the diagnosis of unicystic ameloblastoma.

    PubMed

    Pereira, Núbia Braga; Pereira, Karuza Maria Alves; Coura, Bruna Pizziolo; Diniz, Marina Gonçalves; de Castro, Wagner Henriques; Gomes, Carolina Cavalieri; Gomez, Ricardo Santiago

    2016-11-01

    Unicystic ameloblastoma, an odontogenic neoplasm, presents clinical and radiographic similarities with dentigerous and radicular cysts, non-neoplastic lesions. It is not always possible to reach a final diagnosis with the incisional biopsy, leading to inappropriate treatment. The BRAFV600E activating mutation has been reported in a high proportion of ameloblastomas. The purpose of the study was to assess the utility of the detection of the BRAFV600E mutation in the differential diagnosis of unicystic ameloblastoma with dentigerous and radicular cysts. Twenty-six archival samples were included, comprising eight unicystic ameloblastomas (UAs), nine dentigerous and nine radicular cysts. The mutation was assessed in all samples by anti-BRAFV600E (clone VE1) immunohistochemistry (IHC) and by TaqMan mutation detection qPCR assay. Sanger sequencing was further carried out when samples showed conflicting results in the IHC and qPCR. Although all UAs (8/8) showed positive uniform BRAFV600E staining along the epithelial lining length, the mutation was not confirmed by qPCR and Sanger sequencing in three samples. Positive staining for the BRAFV600E protein was observed in one dentigerous cyst, but it was not confirmed by the molecular methods. Furthermore, 2/9 dentigerous cysts and 2/9 radicular cysts showed non-specific immunostaining of the epithelium or plasma cells. None of the dentigerous or radicular cysts cases presented the BRAFV600E mutation in the qPCR assay. The BRAFV600E antibody (clone VE1) IHC may show non-specific staining, but molecular assays may be useful for the diagnosis of unicystic ameloblastoma, in conjunction with clinical, radiological and histopathological features. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  7. Oxidation Resistance of Materials Based on Ti3AlC2 Nanolaminate at 600 °C in Air

    NASA Astrophysics Data System (ADS)

    Ivasyshyn, Andrij; Ostash, Orest; Prikhna, Tatiana; Podhurska, Viktoriya; Basyuk, Tatiana

    2016-08-01

    The oxidation behavior of Ti3AlC2-based materials had been investigated at 600 °C in static air for 1000 h. It was shown that the intense increase of weight gain per unit surface area for sintered material with porosity of 22 % attributed to oxidation of the outer surface of the specimen and surfaces of pores in the bulk material. The oxidation kinetics of the hot-pressed Ti3AlC2-based material with 1 % porosity remarkably increased for the first 15 h and then slowly decreased. The weight gain per unit surface area for this material was 1.0 mg/cm2 after exposition for 1000 h. The intense initial oxidation of Ti3AlC2-based materials can be eliminated by pre-oxidation treatment at 1200 °C in air for 2 h. As a result, the weight gain per unit surface area for the pre-oxidized material did not exceed 0.11 mg/cm2 after 1000 h of exposition at 600 °C in air. It was demonstrated that the oxidation resistance of Ti3AlC2-based materials can be significantly improved by niobium addition.

  8. 21 CFR 600.20 - Inspectors.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... the Food and Drug Administration having special knowledge of the methods used in the manufacture and... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Inspectors. 600.20 Section 600.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL...

  9. 21 CFR 600.20 - Inspectors.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... the Food and Drug Administration having special knowledge of the methods used in the manufacture and... 21 Food and Drugs 7 2012-04-01 2012-04-01 false Inspectors. 600.20 Section 600.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL...

  10. 21 CFR 600.20 - Inspectors.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... the Food and Drug Administration having special knowledge of the methods used in the manufacture and... 21 Food and Drugs 7 2014-04-01 2014-04-01 false Inspectors. 600.20 Section 600.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL...

  11. 21 CFR 600.3 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Definitions. 600.3 Section 600.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL... Services to whom the authority involved has been delegated. (c) Commissioner of Food and Drugs means the...

  12. 21 CFR 600.3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 7 2014-04-01 2014-04-01 false Definitions. 600.3 Section 600.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL... Services to whom the authority involved has been delegated. (c) Commissioner of Food and Drugs means the...

  13. 21 CFR 600.3 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 7 2012-04-01 2012-04-01 false Definitions. 600.3 Section 600.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL... Services to whom the authority involved has been delegated. (c) Commissioner of Food and Drugs means the...

  14. 21 CFR 600.3 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Definitions. 600.3 Section 600.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL... Services to whom the authority involved has been delegated. (c) Commissioner of Food and Drugs means the...

  15. 21 CFR 600.3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Definitions. 600.3 Section 600.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL... Services to whom the authority involved has been delegated. (c) Commissioner of Food and Drugs means the...

  16. 48 CFR 17.600 - Scope of subpart.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Scope of subpart. 17.600 Section 17.600 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Management and Operating Contracts 17.600 Scope of...

  17. 48 CFR 511.600 - Scope of subpart.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Scope of subpart. 511.600 Section 511.600 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION COMPETITION AND ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Priorities and Allocations 511.600 Scope of subpart. Pursuant to...

  18. 48 CFR 17.600 - Scope of subpart.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Scope of subpart. 17.600 Section 17.600 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Management and Operating Contracts 17.600 Scope of...

  19. 48 CFR 511.600 - Scope of subpart.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Scope of subpart. 511.600 Section 511.600 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION COMPETITION AND ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Priorities and Allocations 511.600 Scope of subpart. Pursuant to...

  20. 48 CFR 17.600 - Scope of subpart.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Scope of subpart. 17.600 Section 17.600 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Management and Operating Contracts 17.600 Scope of...

  1. 48 CFR 17.600 - Scope of subpart.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Scope of subpart. 17.600 Section 17.600 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Management and Operating Contracts 17.600 Scope of...

  2. 48 CFR 17.600 - Scope of subpart.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Scope of subpart. 17.600 Section 17.600 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Management and Operating Contracts 17.600 Scope of...

  3. 50 CFR 600.250 - Council member training.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Council member training. 600.250 Section 600.250 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.250 Council...

  4. 50 CFR 600.150 - Disposition of records.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Disposition of records. 600.150 Section 600.150 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Regional Fishery Management Councils § 600...

  5. 50 CFR 600.150 - Disposition of records.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Disposition of records. 600.150 Section 600.150 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Regional Fishery Management Councils § 600...

  6. 50 CFR 600.150 - Disposition of records.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Disposition of records. 600.150 Section 600.150 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Regional Fishery Management Councils § 600...

  7. 48 CFR 911.600 - Scope of subpart.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Scope of subpart. 911.600 Section 911.600 Federal Acquisition Regulations System DEPARTMENT OF ENERGY COMPETITION ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Priorities and Allocations 911.600 Scope of subpart. This subpart...

  8. 48 CFR 911.600 - Scope of subpart.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Scope of subpart. 911.600 Section 911.600 Federal Acquisition Regulations System DEPARTMENT OF ENERGY COMPETITION ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Priorities and Allocations 911.600 Scope of subpart. This subpart...

  9. 48 CFR 911.600 - Scope of subpart.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Scope of subpart. 911.600 Section 911.600 Federal Acquisition Regulations System DEPARTMENT OF ENERGY COMPETITION ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Priorities and Allocations 911.600 Scope of subpart. This subpart...

  10. 48 CFR 911.600 - Scope of subpart.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Scope of subpart. 911.600 Section 911.600 Federal Acquisition Regulations System DEPARTMENT OF ENERGY COMPETITION ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Priorities and Allocations 911.600 Scope of subpart. This subpart...

  11. 48 CFR 911.600 - Scope of subpart.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Scope of subpart. 911.600 Section 911.600 Federal Acquisition Regulations System DEPARTMENT OF ENERGY COMPETITION ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Priorities and Allocations 911.600 Scope of subpart. This subpart...

  12. 10 CFR 600.304 - Special award conditions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Special award conditions. 600.304 Section 600.304 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES Administrative Requirements for Grants and Cooperative Agreements With For-Profit Organizations General § 600.304 Special...

  13. 40 CFR 600.011 - Incorporation by reference.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Incorporation by reference. 600.011 Section 600.011 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES General Provisions § 600.011 Incorporation...

  14. 40 CFR 600.301-12 - General applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... and Later Model Year Automobiles-Labeling § 600.301-12 General applicability. (a) Unless otherwise... 40 Protection of Environment 29 2010-07-01 2010-07-01 false General applicability. 600.301-12 Section 600.301-12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY...

  15. 40 CFR 600.316-78 - Multistage manufacture.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Multistage manufacture. 600.316-78 Section 600.316-78 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY... and Later Model Year Automobiles-Labeling § 600.316-78 Multistage manufacture. Where more than one...

  16. 10 CFR 490.600 - Purpose and scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Purpose and scope. 490.600 Section 490.600 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Investigations and Enforcement § 490.600 Purpose and scope. This subpart sets forth the rules applicable to investigations under...

  17. 10 CFR 490.600 - Purpose and scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Purpose and scope. 490.600 Section 490.600 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Investigations and Enforcement § 490.600 Purpose and scope. This subpart sets forth the rules applicable to investigations under...

  18. 10 CFR 490.600 - Purpose and scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Purpose and scope. 490.600 Section 490.600 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Investigations and Enforcement § 490.600 Purpose and scope. This subpart sets forth the rules applicable to investigations under...

  19. 10 CFR 490.600 - Purpose and scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Purpose and scope. 490.600 Section 490.600 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Investigations and Enforcement § 490.600 Purpose and scope. This subpart sets forth the rules applicable to investigations under...

  20. 10 CFR 490.600 - Purpose and scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Purpose and scope. 490.600 Section 490.600 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Investigations and Enforcement § 490.600 Purpose and scope. This subpart sets forth the rules applicable to investigations under...

  1. 48 CFR 917.600 - Scope of subpart.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Scope of subpart. 917.600 Section 917.600 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Management and Operating Contracts 917.600 Scope of subpart. (a...

  2. 48 CFR 917.600 - Scope of subpart.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Scope of subpart. 917.600 Section 917.600 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Management and Operating Contracts 917.600 Scope of subpart. (a...

  3. 48 CFR 917.600 - Scope of subpart.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Scope of subpart. 917.600 Section 917.600 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Management and Operating Contracts 917.600 Scope of subpart. (a...

  4. 40 CFR 272.600-272.649 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false [Reserved] 272.600-272.649 Section 272.600-272.649 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Hawaii §§ 272.600-272.649 [Reserved] ...

  5. 40 CFR 272.600-272.649 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false [Reserved] 272.600-272.649 Section 272.600-272.649 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Hawaii §§ 272.600-272.649 [Reserved] ...

  6. 40 CFR 272.600-272.649 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false [Reserved] 272.600-272.649 Section 272.600-272.649 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Hawaii §§ 272.600-272.649 [Reserved] ...

  7. 40 CFR 272.600-272.649 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false [Reserved] 272.600-272.649 Section 272.600-272.649 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Hawaii §§ 272.600-272.649 [Reserved] ...

  8. 40 CFR 272.600-272.649 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false [Reserved] 272.600-272.649 Section 272.600-272.649 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Hawaii §§ 272.600-272.649 [Reserved] ...

  9. 40 CFR 600.316-08 - Multistage manufacture.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 31 2013-07-01 2013-07-01 false Multistage manufacture. 600.316-08 Section 600.316-08 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Labeling § 600.316-08...

  10. 40 CFR 600.316-08 - Multistage manufacture.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Multistage manufacture. 600.316-08 Section 600.316-08 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Labeling § 600.316-08...

  11. 40 CFR 600.316-08 - Multistage manufacture.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Multistage manufacture. 600.316-08 Section 600.316-08 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Labeling § 600.316-08...

  12. 21 CFR 558.600 - Tiamulin.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 6 2013-04-01 2013-04-01 false Tiamulin. 558.600 Section 558.600 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS NEW ANIMAL DRUGS FOR USE IN ANIMAL FEEDS Specific New Animal Drugs for Use in...

  13. 21 CFR 558.600 - Tiamulin.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 6 2012-04-01 2012-04-01 false Tiamulin. 558.600 Section 558.600 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS NEW ANIMAL DRUGS FOR USE IN ANIMAL FEEDS Specific New Animal Drugs for Use in...

  14. 21 CFR 558.600 - Tiamulin.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 6 2014-04-01 2014-04-01 false Tiamulin. 558.600 Section 558.600 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS NEW ANIMAL DRUGS FOR USE IN ANIMAL FEEDS Specific New Animal Drugs for Use in...

  15. 21 CFR 73.600 - Turmeric.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... mixtures for coloring foods. (b) Uses and restrictions. Turmeric may be safely used for the coloring of... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Turmeric. 73.600 Section 73.600 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR...

  16. 21 CFR 600.20 - Inspectors.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Inspectors. 600.20 Section 600.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL... control of products and designated for such purposes by the Commissioner of Food and Drugs, or by any...

  17. 21 CFR 600.20 - Inspectors.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Inspectors. 600.20 Section 600.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL... control of products and designated for such purposes by the Commissioner of Food and Drugs, or by any...

  18. 10 CFR 600.324 - Supplies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... unused supplies. If the inventory of unused supplies exceeds $5,000 in total aggregate value and the... 10 Energy 4 2010-01-01 2010-01-01 false Supplies. 600.324 Section 600.324 Energy DEPARTMENT OF... Supplies. (a) Title vests in the recipient upon acquisition of supplies acquired with Federal funds under...

  19. 10 CFR 600.233 - Supplies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... supplies exceeding $5,000 in total aggregate fair market value upon termination or completion of the award... 10 Energy 4 2010-01-01 2010-01-01 false Supplies. 600.233 Section 600.233 Energy DEPARTMENT OF... Supplies. (a) Title. Title to supplies acquired under a grant or subgrant will vest, upon acquisition, in...

  20. 21 CFR 558.600 - Tiamulin.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Tiamulin. 558.600 Section 558.600 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS NEW ANIMAL DRUGS FOR USE IN ANIMAL FEEDS Specific New Animal Drugs for Use in...

  1. 42 CFR 436.600 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 4 2011-10-01 2011-10-01 false Scope. 436.600 Section 436.600 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL... specified in subparts B, C, and D of this part. Subparts H and I of this part prescribe additional financial...

  2. 42 CFR 436.600 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Scope. 436.600 Section 436.600 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL... specified in subparts B, C, and D of this part. Subparts H and I of this part prescribe additional financial...

  3. 12 CFR 1807.600 - Tracking funds-general.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Tracking funds-general. 1807.600 Section 1807.600 Banks and Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY CAPITAL MAGNET FUND Tracking Requirements § 1807.600 Tracking funds—general. An Awardee receiving a CMF...

  4. 10 CFR 600.111 - Pre-award policies.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Requirements for Grants and Cooperative Agreements With Institutions of Higher Education, Hospitals, and Other Nonprofit Organizations Pre-Award Requirements § 600.111 Pre-award policies. (a) Use of Grants and... 10 Energy 4 2014-01-01 2014-01-01 false Pre-award policies. 600.111 Section 600.111 Energy...

  5. 50 CFR 600.5 - Purpose and scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Purpose and scope. 600.5 Section 600.5 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS General § 600.5 Purpose and scope. (a) This part...

  6. 50 CFR 600.220 - Oath of office.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Oath of office. 600.220 Section 600.220 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.220 Oath of office. As...

  7. 50 CFR 600.225 - Rules of conduct.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Rules of conduct. 600.225 Section 600.225 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.225 Rules of conduct. (a...

  8. 50 CFR 600.5 - Purpose and scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Purpose and scope. 600.5 Section 600.5 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS General § 600.5 Purpose and scope. (a) This part...

  9. 50 CFR 600.5 - Purpose and scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Purpose and scope. 600.5 Section 600.5 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS General § 600.5 Purpose and scope. (a) This part...

  10. 50 CFR 600.805 - Purpose and scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Purpose and scope. 600.805 Section 600.805 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Essential Fish Habitat (EFH) § 600.805 Purpose and...

  11. 46 CFR 308.600 - Records retention requirement.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false Records retention requirement. 308.600 Section 308.600 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE Records Retention § 308.600 Records retention requirement. The records specified in §§ 308.8, 308.517, and...

  12. 46 CFR 308.600 - Records retention requirement.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false Records retention requirement. 308.600 Section 308.600 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE Records Retention § 308.600 Records retention requirement. The records specified in §§ 308.8, 308.517, and...

  13. 46 CFR 308.600 - Records retention requirement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Records retention requirement. 308.600 Section 308.600 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE Records Retention § 308.600 Records retention requirement. The records specified in §§ 308.8, 308.517, and...

  14. 46 CFR 308.600 - Records retention requirement.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Records retention requirement. 308.600 Section 308.600 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE Records Retention § 308.600 Records retention requirement. The records specified in §§ 308.8, 308.517, and...

  15. 46 CFR 308.600 - Records retention requirement.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false Records retention requirement. 308.600 Section 308.600 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE Records Retention § 308.600 Records retention requirement. The records specified in §§ 308.8, 308.517, and...

  16. 10 CFR 600.20 - Maximum DOE obligation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Maximum DOE obligation. 600.20 Section 600.20 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES General § 600.20 Maximum DOE obligation. (a) The maximum DOE obligation to the recipient is— (1) For monetary awards, the...

  17. 50 CFR 600.415 - Access to statistics.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Access to statistics. 600.415 Section 600... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Confidentiality of Statistics § 600.415 Access to statistics. (a) General. In determining whether to grant a request for access to confidential...

  18. 50 CFR 600.425 - Release of statistics.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Release of statistics. 600.425 Section 600... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Confidentiality of Statistics § 600.425 Release of statistics. (a) The Assistant Administrator will not release to the public any statistics...

  19. Local T1-T2 distribution measurements in porous media

    NASA Astrophysics Data System (ADS)

    Vashaee, S.; Li, M.; Newling, B.; MacMillan, B.; Marica, F.; Kwak, H. T.; Gao, J.; Al-harbi, A. M.; Balcom, B. J.

    2018-02-01

    A novel slice-selective T1-T2 measurement is proposed to measure spatially resolved T1-T2 distributions. An adiabatic inversion pulse is employed for slice-selection. The slice-selective pulse is able to select a quasi-rectangular slice, on the order of 1 mm, at an arbitrary position within the sample. The method does not employ conventional selective excitation in which selective excitation is often accomplished by rotation of the longitudinal magnetization in the slice of interest into the transverse plane, but rather a subtraction based on CPMG data acquired with and without adiabatic inversion slice selection. T1 weighting is introduced during recovery from the inversion associated with slice selection. The local T1-T2 distributions measured are of similar quality to bulk T1-T2 measurements. The new method can be employed to characterize oil-water mixtures and other fluids in porous media. The method is beneficial when a coarse spatial distribution of the components is of interest.

  20. 75 FR 61348 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-05

    ... CFR Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by reference, Safety... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010... Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440) Airplanes AGENCY...

  1. 30 CFR 71.600 - Drinking water; general.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Drinking water; general. 71.600 Section 71.600 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH... Water § 71.600 Drinking water; general. An adequate supply of potable water shall be provided for...

  2. 30 CFR 71.600 - Drinking water; general.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Drinking water; general. 71.600 Section 71.600 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH... Water § 71.600 Drinking water; general. An adequate supply of potable water shall be provided for...

  3. 45 CFR 1168.600 - Semi-annual compilation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 3 2011-10-01 2011-10-01 false Semi-annual compilation. 1168.600 Section 1168.600 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE HUMANITIES NEW RESTRICTIONS ON LOBBYING Agency Reports § 1168.600 Semi...

  4. 45 CFR 1168.600 - Semi-annual compilation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Semi-annual compilation. 1168.600 Section 1168.600 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE HUMANITIES NEW RESTRICTIONS ON LOBBYING Agency Reports § 1168.600 Semi...

  5. 7 CFR 600.8 - Plant materials centers.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Plant materials centers. 600.8 Section 600.8..., DEPARTMENT OF AGRICULTURE GENERAL ORGANIZATION § 600.8 Plant materials centers. Plant materials centers (PMC) assemble and test plant species for conservation uses. Usually a PMC serves two or more States, and is...

  6. 7 CFR 600.8 - Plant materials centers.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Plant materials centers. 600.8 Section 600.8..., DEPARTMENT OF AGRICULTURE GENERAL ORGANIZATION § 600.8 Plant materials centers. Plant materials centers (PMC) assemble and test plant species for conservation uses. Usually a PMC serves two or more States, and is...

  7. 7 CFR 600.8 - Plant materials centers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Plant materials centers. 600.8 Section 600.8..., DEPARTMENT OF AGRICULTURE GENERAL ORGANIZATION § 600.8 Plant materials centers. Plant materials centers (PMC) assemble and test plant species for conservation uses. Usually a PMC serves two or more States, and is...

  8. 7 CFR 600.8 - Plant materials centers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Plant materials centers. 600.8 Section 600.8..., DEPARTMENT OF AGRICULTURE GENERAL ORGANIZATION § 600.8 Plant materials centers. Plant materials centers (PMC) assemble and test plant species for conservation uses. Usually a PMC serves two or more States, and is...

  9. 7 CFR 600.8 - Plant materials centers.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Plant materials centers. 600.8 Section 600.8..., DEPARTMENT OF AGRICULTURE GENERAL ORGANIZATION § 600.8 Plant materials centers. Plant materials centers (PMC) assemble and test plant species for conservation uses. Usually a PMC serves two or more States, and is...

  10. 21 CFR 600.22 - Duties of inspector.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Duties of inspector. 600.22 Section 600.22 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL PRODUCTS: GENERAL Establishment Inspection § 600.22 Duties of inspector. The inspector shall: (a...

  11. 21 CFR 600.22 - Duties of inspector.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Duties of inspector. 600.22 Section 600.22 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL PRODUCTS: GENERAL Establishment Inspection § 600.22 Duties of inspector. The inspector shall: (a...

  12. 10 CFR 600.137 - Property trust relationship.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Property trust relationship. 600.137 Section 600.137..., Hospitals, and Other Nonprofit Organizations Post-Award Requirements § 600.137 Property trust relationship... Federal funds shall be held in trust by the recipient as trustee for the beneficiaries of the project or...

  13. 30 CFR 71.600 - Drinking water; general.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Drinking water; general. 71.600 Section 71.600 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH... Water § 71.600 Drinking water; general. An adequate supply of potable water shall be provided for...

  14. 30 CFR 71.600 - Drinking water; general.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Drinking water; general. 71.600 Section 71.600 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH... Water § 71.600 Drinking water; general. An adequate supply of potable water shall be provided for...

  15. 30 CFR 71.600 - Drinking water; general.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Drinking water; general. 71.600 Section 71.600 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH... Water § 71.600 Drinking water; general. An adequate supply of potable water shall be provided for...

  16. 21 CFR 600.21 - Time of inspection.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Time of inspection. 600.21 Section 600.21 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL PRODUCTS: GENERAL Establishment Inspection § 600.21 Time of inspection. The inspection of an...

  17. P - ρ - T data for H2O up to 260 GPa under laser-driven shock loading

    NASA Astrophysics Data System (ADS)

    Kimura, T.; Ozaki, N.; Sano, T.; Okuchi, T.; Shimizu, K.; Miyanishi, K.; Terai, T.; Kakeshita, T.; Sakawa, Y.; Kodama, R.

    2014-12-01

    .109-138. 2S. P. Lyon and J. D. Johnson, Los Alamos Technical Report No. LA-UR-92-3407, 1992. 3F. H. Ree, Lawrence Livemore Laboratory Technical Report No. UCRL-52190, 1976. 4M. French et al., Phys. Rev. B 79, 054107 (2009). 5M. D. Knudson et al., Phys. Rev. Lett. 108, 091102 (2012). 6 R. Redmer et al., Icarus 211, 798 (2011). 7T. Kimura et al., J. Chem. Phys. 140, 074501 (2014).

  18. 40 CFR 600.210-12 - Calculation of fuel economy and CO2 emission values for labeling.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... not qualify for the second method as described in § 600.115 (other than electric vehicles). The second... values for electric vehicles. Determine FTP-based city and HFET-based highway fuel economy label values for electric vehicles as described in § 600.116. Convert W-hour/mile results to miles per kW-hr and...

  19. 40 CFR 600.210-12 - Calculation of fuel economy and CO2 emission values for labeling.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... not qualify for the second method as described in § 600.115 (other than electric vehicles). The second... values for electric vehicles. Determine FTP-based city and HFET-based highway fuel economy label values for electric vehicles as described in § 600.116. Convert W-hour/mile results to miles per kW-hr and...

  20. 40 CFR 600.210-12 - Calculation of fuel economy and CO2 emission values for labeling.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... not qualify for the second method as described in § 600.115 (other than electric vehicles). The second... values for electric vehicles. Determine FTP-based city and HFET-based highway fuel economy label values for electric vehicles as described in § 600.116. Convert W-hour/mile results to miles per kW-hr and...

  1. 24 CFR 87.600 - Semi-annual compilation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Semi-annual compilation. 87.600 Section 87.600 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development NEW RESTRICTIONS ON LOBBYING Agency Reports § 87.600 Semi-annual compilation. (a) The head of each...

  2. 12 CFR 411.600 - Semi-annual compilation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Semi-annual compilation. 411.600 Section 411.600 Banks and Banking EXPORT-IMPORT BANK OF THE UNITED STATES NEW RESTRICTIONS ON LOBBYING Agency Reports § 411.600 Semi-annual compilation. (a) The head of each agency shall collect and compile the...

  3. 32 CFR 28.600 - Semi-annual compilation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Semi-annual compilation. 28.600 Section 28.600 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS NEW RESTRICTIONS ON LOBBYING Agency Reports § 28.600 Semi-annual compilation. (a) The head of each...

  4. 32 CFR 28.600 - Semi-annual compilation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Semi-annual compilation. 28.600 Section 28.600 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS NEW RESTRICTIONS ON LOBBYING Agency Reports § 28.600 Semi-annual compilation. (a) The head of each...

  5. 32 CFR 28.600 - Semi-annual compilation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Semi-annual compilation. 28.600 Section 28.600 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS NEW RESTRICTIONS ON LOBBYING Agency Reports § 28.600 Semi-annual compilation. (a) The head of each...

  6. 32 CFR 28.600 - Semi-annual compilation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Semi-annual compilation. 28.600 Section 28.600 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS NEW RESTRICTIONS ON LOBBYING Agency Reports § 28.600 Semi-annual compilation. (a) The head of each...

  7. 32 CFR 28.600 - Semi-annual compilation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Semi-annual compilation. 28.600 Section 28.600 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS NEW RESTRICTIONS ON LOBBYING Agency Reports § 28.600 Semi-annual compilation. (a) The head of each...

  8. Retracted: Association of ACE I/D gene polymorphism with T2DN susceptibility and the risk of T2DM developing into T2DN in a Caucasian population.

    PubMed

    Liu, Guohui; Zhou, Tian-Biao; Jiang, Zongpei; Zheng, Dongwen

    2015-03-01

    The association of the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism with type-2 diabetic nephropathy (T2DN) susceptibility and the risk of type-2 diabetes mellitus (T2DM) developing into T2DN in Caucasian populations is still controversial. A meta-analysis was performed to evaluate the association of ACE I/D gene polymorphism with T2DN susceptibility and the risk of T2DM developing into T2DN in Caucasian populations. A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases. Sixteen articles were identified for the analysis of the association of ACE I/D gene polymorphism with T2DN susceptibility and the risk of T2DM developing into T2DN in Caucasian populations. ACE I/D gene polymorphism was not associated with T2DN susceptibility and the risk of patients with T2DM developing T2DN in Caucasian populations. Sensitivity analysis according to sample size of case (<100 vs. ≥100) was also performed, and the results were similar to the non-sensitivity analysis. ACE I/D gene polymorphism was not associated with T2DN susceptibility and the risk of patients with T2DM developing T2DN in Caucasian populations. However, more studies should be performed in the future. © The Author(s) 2014.

  9. 75 FR 11422 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-11

    ... Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by reference, Safety. Adoption of... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2009... Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440) Airplanes AGENCY...

  10. 75 FR 19203 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-14

    ... transportation, Aircraft, Aviation safety, Incorporation by reference, Safety. Adoption of the Amendment 0... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2009... Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440) Airplanes AGENCY...

  11. 76 FR 71241 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-17

    ..., Aircraft, Aviation safety, Incorporation by reference, Safety. Adoption of the Amendment Accordingly, under... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2011... Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440) Airplanes AGENCY...

  12. 75 FR 10667 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-09

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010... Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440) Airplanes AGENCY: Federal Aviation Administration (FAA), Department of Transportation (DOT). ACTION: Final rule; request for...

  13. 75 FR 52233 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-25

    ... transportation, Aircraft, Aviation safety, Incorporation by reference, Safety. Adoption of the Amendment 0... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010... Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440) Airplanes AGENCY...

  14. 76 FR 29997 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-24

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010... Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440) Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule; correction. SUMMARY: The FAA is correcting...

  15. 76 FR 15823 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-22

    ..., and CL-600-2D24 (Regional Jet Series 900) Airplanes AGENCY: Federal Aviation Administration (FAA.... List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010...

  16. 76 FR 38065 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    .... Model CL-600-2B19 (Regional Jet Series 100 & 440) Airplanes AGENCY: Federal Aviation Administration (FAA... Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by reference, Safety. The Proposed... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2011...

  17. 75 FR 35613 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2C10 (Regional Jet Series 700 & 701...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-23

    ... transportation, Aircraft, Aviation safety, Incorporation by reference, Safety. Adoption of the Amendment 0... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2009... Airworthiness Directives; Bombardier, Inc. Model CL-600-2C10 (Regional Jet Series 700 & 701) Airplanes, Model CL...

  18. 75 FR 31324 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-03

    .... Model CL-600-2B19 (Regional Jet Series 100 & 440) Airplanes AGENCY: Federal Aviation Administration (FAA... Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by reference, Safety. The Proposed... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010...

  19. Can T1 w/T2 w ratio be used as a myelin-specific measure in subcortical structures? Comparisons between FSE-based T1 w/T2 w ratios, GRASE-based T1 w/T2 w ratios and multi-echo GRASE-based myelin water fractions.

    PubMed

    Uddin, Md Nasir; Figley, Teresa D; Marrie, Ruth Ann; Figley, Chase R

    2018-03-01

    Given the growing popularity of T 1 -weighted/T 2 -weighted (T 1 w/T 2 w) ratio measurements, the objective of the current study was to evaluate the concordance between T 1 w/T 2 w ratios obtained using conventional fast spin echo (FSE) versus combined gradient and spin echo (GRASE) sequences for T 2 w image acquisition, and to compare the resulting T 1 w/T 2 w ratios with histologically validated myelin water fraction (MWF) measurements in several subcortical brain structures. In order to compare these measurements across a relatively wide range of myelin concentrations, whole-brain T 1 w magnetization prepared rapid acquisition gradient echo (MPRAGE), T 2 w FSE and three-dimensional multi-echo GRASE data were acquired from 10 participants with multiple sclerosis at 3 T. Then, after high-dimensional, non-linear warping, region of interest (ROI) analyses were performed to compare T 1 w/T 2 w ratios and MWF estimates (across participants and brain regions) in 11 bilateral white matter (WM) and four bilateral subcortical grey matter (SGM) structures extracted from the JHU_MNI_SS 'Eve' atlas. Although the GRASE sequence systematically underestimated T 1 w/T 2 w values compared to the FSE sequence (revealed by Bland-Altman and mountain plots), linear regressions across participants and ROIs revealed consistently high correlations between the two methods (r 2 = 0.62 for all ROIs, r 2 = 0.62 for WM structures and r 2 = 0.73 for SGM structures). However, correlations between either FSE-based or GRASE-based T 1 w/T 2 w ratios and MWFs were extremely low in WM structures (FSE-based, r 2 = 0.000020; GRASE-based, r 2 = 0.0014), low across all ROIs (FSE-based, r 2 = 0.053; GRASE-based, r 2 = 0.029) and moderate in SGM structures (FSE-based, r 2 = 0.20; GRASE-based, r 2 = 0.17). Overall, our findings indicated a high degree of correlation (but not equivalence) between FSE-based and GRASE-based T 1 w/T 2 w ratios, and low correlations between T 1 w/T 2 w ratios and MWFs. This

  20. 12 CFR 600.10 - Service of Process.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Service of Process. 600.10 Section 600.10 Banks... Procedures for Service Upon the Farm Credit Administration § 600.10 Service of Process. (a) Except as... Administration Board, 1501 Farm Credit Drive, McLean, Virginia 22102-5090. (b) Service of process upon the...

  1. Electronic properties of in-plane phase engineered 1T'/2H/1T' MoS2

    NASA Astrophysics Data System (ADS)

    Thakur, Rajesh; Sharma, Munish; Ahluwalia, P. K.; Sharma, Raman

    2018-04-01

    We present the first principles studies of semi-infinite phase engineered MoS2 along zigzag direction. The semiconducting (2H) and semi-metallic (1T') phases are known to be stable in thin-film MoS2. We described the electronic and structural properties of the infinite array of 1T'/2H/1T'. It has been found that 1T'phase induced semi-metallic character in 2H phase beyond interface but, only Mo atoms in 2H phase domain contribute to the semi-metallic nature and S atoms towards semiconducting state. 1T'/2H/1T' system can act as a typical n-p-n structure. Also high holes concentration at the interface of Mo layer provides further positive potential barriers.

  2. 75 FR 69609 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-15

    .... Model CL-600-2B19 (Regional Jet Series 100 & 440) Airplanes AGENCY: Federal Aviation Administration (FAA... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010... airworthiness information (MCAI) originated by an aviation authority of another country to identify and correct...

  3. 75 FR 25788 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-10

    .... Model CL-600-2B19 (Regional Jet Series 100 & 440) Airplanes AGENCY: Federal Aviation Administration (FAA.... List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010...

  4. 75 FR 37708 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-30

    .... List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2009... Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440) Airplanes AGENCY...

  5. 75 FR 64636 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-20

    ... docket. List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety, Incorporation... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010... Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440) Airplanes AGENCY...

  6. 75 FR 63054 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-14

    .... List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2009... Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440) Airplanes AGENCY...

  7. 75 FR 22521 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-29

    ... after receipt. List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2009... Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440) Airplanes AGENCY...

  8. 75 FR 17086 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-05

    .... Model CL-600-2B19 (Regional Jet Series 100 & 440) Airplanes AGENCY: Federal Aviation Administration (FAA... the AD docket. List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010...

  9. Correlation study between facet joint cartilage and intervertebral discs in early lumbar vertebral degeneration using T2, T2* and T1ρ mapping

    PubMed Central

    Zhang, Yi; Hu, Jianzhong; Duan, Chunyue; Hu, Ping; Lu, Hongbin; Peng, Xianjing

    2017-01-01

    Recent advancements in magnetic resonance imaging have allowed for the early detection of biochemical changes in intervertebral discs and articular cartilage. Here, we assessed the feasibility of axial T2, T2* and T1ρ mapping of the lumbar facet joints (LFJs) to determine correlations between cartilage and intervertebral discs (IVDs) in early lumbar vertebral degeneration. We recruited 22 volunteers and examined 202 LFJs and 101 IVDs with morphological (sagittal and axial FSE T2-weighted imaging) and axial biochemical (T2, T2* and T1ρ mapping) sequences using a 3.0T MRI scanner. IVDs were graded using the Pfirrmann system. Mapping values of LFJs were recorded according to the degeneration grades of IVDs at the same level. The feasibility of T2, T2* and T1ρ in IVDs and LFJs were analyzed by comparing these mapping values across subjects with different rates of degeneration using Kruskal-Wallis tests. A Pearson’s correlation analysis was used to compare T2, T2* and T1ρ values of discs and LFJs. We found excellent reproducibility in the T2, T2* and T1ρ values for the nucleus pulposus (NP), anterior and posterior annulus fibrosus (PAF), and LFJ cartilage (intraclass correlation coefficients 0.806–0.955). T2, T2* and T1ρ mapping (all P<0.01) had good Pfirrmann grade performances in the NP with IVD degeneration. LFJ T2* values were significantly different between grades I and IV (PL = 0.032, PR = 0.026), as were T1ρ values between grades II and III (PL = 0.002, PR = 0.006) and grades III and IV (PL = 0.006, PR = 0.001). Correlations were moderately negative for T1ρ values between LFJ cartilage and NP (rL = −0.574, rR = −0.551), and between LFJ cartilage and PAF (rL = −0.551, rR = −0.499). T1ρ values of LFJ cartilage was weakly correlated with T2 (r = 0.007) and T2* (r = −0.158) values. Overall, we show that axial T1ρ effectively assesses early LFJ cartilage degeneration. Using T1ρ analysis, we propose a link between LFJ degeneration and IVD NP or

  10. Spherically symmetric vacuum in covariant F (T )=T +α/2 T2+O (Tγ) gravity theory

    NASA Astrophysics Data System (ADS)

    DeBenedictis, Andrew; Ilijić, Saša

    2016-12-01

    Recently, a fully covariant version of the theory of F (T ) torsion gravity has been introduced by M. Kršśák and E. Saridakis [Classical Quantum Gravity 33, 115009 (2016)]. In covariant F (T ) gravity, the Schwarzschild solution is not a vacuum solution for F (T )≠T , and therefore determining the spherically symmetric vacuum is an important open problem. Within the covariant framework, we perturbatively solve the spherically symmetric vacuum gravitational equations around the Schwarzschild solution for the scenario with F (T )=T +(α /2 )T2 , representing the dominant terms in theories governed by Lagrangians analytic in the torsion scalar. From this, we compute the perihelion shift correction to solar system planetary orbits as well as perturbative gravitational effects near neutron stars. This allows us to set an upper bound on the magnitude of the coupling constant, α , which governs deviations from general relativity. We find the bound on this nonlinear torsion coupling constant by specifically considering the uncertainty in the perihelion shift of Mercury. We also analyze a bound from a similar comparison with the periastron orbit of the binary pulsar PSR J0045-7319 as an independent check for consistency. Setting bounds on the dominant nonlinear coupling is important in determining if other effects in the Solar System or greater universe could be attributable to nonlinear torsion.

  11. 75 FR 59073 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-27

    ...) and Model CL-600-2D24 (Regional Jet Series 900) Airplanes AGENCY: Federal Aviation Administration (FAA... blade failure), loss of ADG electrical power and structural damage to the aircraft and, if deployment... failure on similar ADGs [air-driven generators]/ram air turbines installed on other aircraft types...

  12. 75 FR 60604 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-01

    ...) Airplanes; and Model CL-600-2D24 (Regional Jet Series 900) Airplanes AGENCY: Federal Aviation Administration... possibly result in damage to the aircraft structure. If deployment was activated by a dual engine shutdown... after receipt. List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety...

  13. 50 CFR 600.740 - Enforcement policy.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Enforcement policy. 600.740 Section 600.740 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS General Provisions for Domestic Fisheries...

  14. 50 CFR 600.1007 - Reduction amendments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Reduction amendments. 600.1007 Section 600.1007 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC....1007 Reduction amendments. (a) Each reduction amendment may contain provisions that are either...

  15. Synthesis and characterization of two layered aluminophosphates, ( T) 2HAl 2P 3O 12 ( T=2-BuNH 3+) and ( T)H 2Al 2P 3O 12 ( T=pyH +)

    NASA Astrophysics Data System (ADS)

    Chippindale, Ann M.; Powell, Anthony V.; Bull, Lucy M.; Jones, Richard H.; Cheetham, Anthony K.; Thomas, John M.; Xu, Ruren

    1992-01-01

    Two new aluminophosphates, ( T) 2HAl 2P 3O 12 ( T=2-BuNH 3+) ( I) and ( T)H 2Al 2P 3O 12 ( T=pyH +) ( II) with the same framework stoichiometry but different layer structures have been prepared under nonaqueous conditions and the structures determined by single-crystal X-ray diffraction. Compound ( I) crystallizes in the monoclinic space group P2 1/ c ( Z=4), with lattice parameters a=9.261(1) b=8.365(6), c=27.119(4) Å, β=91.50(1)δ, and V=2100.1 Å 3 ( R=0.072 and R w=0.090). The structure consists of Al-and P-centered tetrahedra linked to form layers. Protonated 2-butylamine molecules are located in the interlayer spaces and hydrogen bonded to the layers through NH 3+ groups. Weak hydrophobic van der Waals' interactions between alkyl groups of the 2-BuNH 3+ cations hold the layers together. Compound ( II) crystallizes in the triclinic space group P-1 ( Z=2), with a=8.574(2), b=8.631(3), c=10.371(2) Å, α=81.84(3), β=87.53(2), γ=69.07(2)δ, and V=709.49Å 3 ( R=0.039 and R w=0.052). The structure contains tetrahedrally coordinated P atoms and both tetrahedral and trigonal pyramidal Al atoms linked to form layers which are held together through hydrogen bonding, creating cavities in which pyH + cations reside.

  16. 76 FR 18957 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2C10 (Regional Jet Series 700, 701 & 702...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-06

    ... Model CL-600-2D24 (Regional Jet Series 900) Airplanes AGENCY: Federal Aviation Administration (FAA), DOT... referred to Task 05- 51-27-210-801 of Part 2, Volume 1, of the Bombardier CRJ Series Regional Jet Aircraft... Regulatory Flexibility Act. List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety...

  17. 50 CFR 600.1002 - General requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false General requirements. 600.1002 Section 600.1002 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC....1002 General requirements. (a) Each program must be: (1) Necessary to prevent or end overfishing...

  18. 50 CFR 600.1002 - General requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false General requirements. 600.1002 Section 600.1002 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC....1002 General requirements. (a) Each program must be: (1) Necessary to prevent or end overfishing...

  19. 50 CFR 600.1002 - General requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false General requirements. 600.1002 Section 600.1002 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC....1002 General requirements. (a) Each program must be: (1) Necessary to prevent or end overfishing...

  20. 50 CFR 600.1002 - General requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false General requirements. 600.1002 Section 600.1002 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC....1002 General requirements. (a) Each program must be: (1) Necessary to prevent or end overfishing...

  1. 76 FR 4264 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2C10 (Regional Jet Series 700, 701, & 702...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-25

    ...-600-2D24 (Regional Jet Series 900) Airplanes AGENCY: Federal Aviation Administration (FAA), DOT... Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by reference, Safety. The Proposed... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2011...

  2. 40 CFR 600.102-78 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Definitions. 600.102-78 Section 600.102-78 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Regulations for 1978 and Later...

  3. 40 CFR 600.303-77 - Abbreviations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Abbreviations. 600.303-77 Section 600.303-77 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Regulations for 1977 and Later...

  4. 40 CFR 600.302-77 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Definitions. 600.302-77 Section 600.302-77 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Regulations for 1977 and Later...

  5. 40 CFR 600.003-77 - Abbreviations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Abbreviations. 600.003-77 Section 600.003-77 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Regulations for 1977 and Later...

  6. 40 CFR 600.105-78 - Recordkeeping.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Recordkeeping. 600.105-78 Section 600.105-78 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Regulations for 1978 and Later...

  7. 40 CFR 600.305-77 - Recordkeeping.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Recordkeeping. 600.305-77 Section 600.305-77 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Regulations for 1977 and Later...

  8. 40 CFR 600.103-78 - Abbreviations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Abbreviations. 600.103-78 Section 600.103-78 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Regulations for 1978 and Later...

  9. 50 CFR 600.757 - Operational protocols.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Operational protocols. 600.757 Section 600.757 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Operational protocols. (a) Services of conveners and facilitators. A Council or NMFS may employ or enter into...

  10. Rejecting Non-MIP-Like Tracks using Boosted Decision Trees with the T2K Pi-Zero Subdetector

    NASA Astrophysics Data System (ADS)

    Hogan, Matthew; Schwehr, Jacklyn; Cherdack, Daniel; Wilson, Robert; T2K Collaboration

    2016-03-01

    Tokai-to-Kamioka (T2K) is a long-baseline neutrino experiment with a narrow band energy spectrum peaked at 600 MeV. The Pi-Zero detector (PØD) is a plastic scintillator-based detector located in the off-axis near detector complex 280 meters from the beam origin. It is designed to constrain neutral-current induced π0 production background at the far detector using the water target which is interleaved between scintillator layers. A PØD-based measurement of charged-current (CC) single charged pion (1π+) production on water is being developed which will have expanded phase space coverage as compared to the previous analysis. The signal channel for this analysis, which for T2K is dominated by Δ production, is defined as events that produce a single muon, single charged pion, and any number of nucleons in the final state. The analysis will employ machine learning algorithms to enhance CC1π+ selection by studying topological observables that characterize signal well. Important observables for this analysis are those that discriminate a minimum ionizing particle (MIP) like a muon or pion from a proton at the T2K energies. This work describes the development of a discriminator using Boosted Decision Trees to reject non-MIP-like PØD tracks.

  11. 50 CFR 600.330 - National Standard 5-Efficiency.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false National Standard 5-Efficiency. 600.330 Section 600.330 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS National Standards § 600...

  12. 50 CFR 600.510 - Gear avoidance and disposal.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Gear avoidance and disposal. 600.510 Section 600.510 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.510...

  13. 50 CFR 600.512 - Scientific research.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Scientific research. 600.512 Section 600... research. (a) Scientific research activity. Persons planning to conduct scientific research activities on board a scientific research vessel in the EEZ that may be confused with fishing are encouraged to submit...

  14. 50 CFR 600.512 - Scientific research.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Scientific research. 600.512 Section 600... research. (a) Scientific research activity. Persons planning to conduct scientific research activities on board a scientific research vessel in the EEZ that may be confused with fishing are encouraged to submit...

  15. 50 CFR 600.512 - Scientific research.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Scientific research. 600.512 Section 600... research. (a) Scientific research activity. Persons planning to conduct scientific research activities on board a scientific research vessel in the EEZ that may be confused with fishing are encouraged to submit...

  16. 50 CFR 600.512 - Scientific research.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Scientific research. 600.512 Section 600... research. (a) Scientific research activity. Persons planning to conduct scientific research activities on board a scientific research vessel in the EEZ that may be confused with fishing are encouraged to submit...

  17. 50 CFR 600.512 - Scientific research.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Scientific research. 600.512 Section 600... research. (a) Scientific research activity. Persons planning to conduct scientific research activities on board a scientific research vessel in the EEZ that may be confused with fishing are encouraged to submit...

  18. 50 CFR 600.1012 - Reduction loan.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... annual rate, that shall be determined by subsequent events, of simple interest on the reduction loan's... deposit and disburse the fee revenue in accordance with § 600.1014. (b) Principal amount, interest rate... § 600.1014. (c) Effect of prospective interest rate. Any difference between a prospective interest rate...

  19. 24 CFR 954.600 - Performance reviews.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Performance reviews. 954.600... DEVELOPMENT INDIAN HOME PROGRAM Performance Reviews and Sanctions § 954.600 Performance reviews. (a) General. HUD will review the performance of each grantee in carrying out its responsibilities under this part...

  20. 24 CFR 954.600 - Performance reviews.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false Performance reviews. 954.600... DEVELOPMENT INDIAN HOME PROGRAM Performance Reviews and Sanctions § 954.600 Performance reviews. (a) General. HUD will review the performance of each grantee in carrying out its responsibilities under this part...

  1. 50 CFR 600.135 - Meeting procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Meeting procedures. 600.135 Section 600....135 Meeting procedures. Link to an amendment published at 75 FR 59150, Sept. 27, 2010. (a) Public notice of regular meetings of the Council, scientific statistical committee or advisory panels, including...

  2. 50 CFR 600.210 - Terms of Council members.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Terms of Council members. 600.210 Section 600.210 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.210 Terms of...

  3. 50 CFR 600.210 - Terms of Council members.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Terms of Council members. 600.210 Section 600.210 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.210 Terms of...

  4. 50 CFR 600.210 - Terms of Council members.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Terms of Council members. 600.210 Section 600.210 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.210 Terms of...

  5. 10 CFR 600.502 - What must DOE determine.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false What must DOE determine. 600.502 Section 600.502 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES Eligibility Determination for Certain Financial Assistance Programs-General Statement of Policy § 600.502 What must DOE...

  6. 75 FR 25791 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2C10 (Regional Jet Series 700, 701, & 702...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-10

    ... Series 705) Airplanes, and Model CL-600-2D24 (Regional Jet Series 900) Airplanes AGENCY: Federal Aviation... Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by reference, Safety. The Proposed... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010...

  7. 40 CFR 600.002-93 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... traveled by an automobile or group of automobiles per volume of fuel consumed as computed in § 600.113 or § 600.207; or (ii) The equivalent petroleum-based fuel economy for an electrically powered automobile as... means the equivalent petroleum-based fuel economy value as determined by the calculation procedure...

  8. 42 CFR 600.165 - Nondiscrimination standards.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... standards. (a) The State and standard health plans, must comply with all applicable civil rights statutes and requirements, including Title VI of the Civil Rights Act of 1964, Title II of the Americans with... 42 Public Health 5 2014-10-01 2014-10-01 false Nondiscrimination standards. 600.165 Section 600...

  9. 10 CFR 600.225 - Program income.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Program income. 600.225 Section 600.225 Energy DEPARTMENT....225 Program income. (a) General. Grantees are encouraged to earn income to defray program costs. Program income includes income from fees for services performed, from the use or rental of real or...

  10. 21 CFR 600.13 - Retention samples.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... specific products required to be submitted to the Center for Biologics Evaluation and Research or the... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Retention samples. 600.13 Section 600.13 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS...

  11. 21 CFR 600.13 - Retention samples.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... specific products required to be submitted to the Center for Biologics Evaluation and Research or the... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Retention samples. 600.13 Section 600.13 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS...

  12. 40 CFR 600.109-08 - EPA driving cycles.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 30 2011-07-01 2011-07-01 false EPA driving cycles. 600.109-08 Section 600.109-08 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL... Emission Regulations for 1978 and Later Model Year Automobiles-Test Procedures § 600.109-08 EPA driving...

  13. 40 CFR 600.109-78 - EPA driving cycles.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 30 2011-07-01 2011-07-01 false EPA driving cycles. 600.109-78 Section 600.109-78 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL... Emission Regulations for 1978 and Later Model Year Automobiles-Test Procedures § 600.109-78 EPA driving...

  14. 50 CFR 600.705 - Relation to other laws.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Relation to other laws. 600.705 Section 600.705 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 600.705 Relation to other laws. (a) General. Persons affected by these regulations should be aware...

  15. 50 CFR 600.705 - Relation to other laws.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Relation to other laws. 600.705 Section 600.705 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 600.705 Relation to other laws. (a) General. Persons affected by these regulations should be aware...

  16. 50 CFR 600.705 - Relation to other laws.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Relation to other laws. 600.705 Section 600.705 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 600.705 Relation to other laws. (a) General. Persons affected by these regulations should be aware...

  17. 50 CFR 600.405 - Types of statistics covered.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Types of statistics covered. 600.405 Section 600.405 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND... Statistics § 600.405 Types of statistics covered. NOAA is authorized under the Magnuson-Stevens Act and other...

  18. 50 CFR 600.705 - Relation to other laws.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Relation to other laws. 600.705 Section 600.705 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 600.705 Relation to other laws. (a) General. Persons affected by these regulations should be aware...

  19. 10 CFR 600.145 - Cost and price analysis.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

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