MWPC prototyping and testing for STAR inner TPC upgrade

NASA Astrophysics Data System (ADS)

Shen, F.; Wang, S.; Yang, C.; Xu, Q.

2017-06-01

STAR experiment at the Relativistic Heavy Ion Collider (RHIC) is upgrading the inner sectors of the Time Projection Chamber (iTPC). The iTPC upgrade project will increase the segmentation on the inner pad plane from 13 to 40 pad rows and renew the inner sector wire chambers. The upgrade will expand the TPC's acceptance from |η|<=1.0 to |η|<=1.5. Furthermore, the detector will have better acceptance for tracks with low momentum, as well as better resolution in both momentum and dE/dx for tracks of all momenta. The enhanced measurement capabilities of STAR-iTPC upgrade are crucial to the physics program of the Phase II of Beam Energy Scan (BES-II) at RHIC during 2019-2020, in particular the QCD phase transition study. In this proceedings, I will discuss the iTPC MWPC module fabrication and testing results from the first full size iTPC MWPC pre-prototype made at Shandong University.

Transaction Processing Performance Council (TPC): State of the Council 2010

NASA Astrophysics Data System (ADS)

Nambiar, Raghunath; Wakou, Nicholas; Carman, Forrest; Majdalany, Michael

The Transaction Processing Performance Council (TPC) is a non-profit corporation founded to define transaction processing and database benchmarks and to disseminate objective, verifiable performance data to the industry. Established in August 1988, the TPC has been integral in shaping the landscape of modern transaction processing and database benchmarks over the past twenty-two years. This paper provides an overview of the TPC's existing benchmark standards and specifications, introduces two new TPC benchmarks under development, and examines the TPC's active involvement in the early creation of additional future benchmarks.

Integrated Cognitive-neuroscience Architectures for Understanding Sensemaking (ICArUS): Phase 2 Challenge Problem Walkthrough

DTIC Science & Technology

2014-11-01

Integrated Cognitive-neuroscience Architectures for Understanding Sensemaking (ICArUS): Phase 2 Challenge Problem Walkthrough Kevin Burns...neuroscience Architectures for Understanding Sensemaking (ICArUS) Phase 2 challenge problem. The pages include screen shots from the tutorial that...Burns, K., Fine, M., Bonaceto, C., & Oertel, C. (2014). Integrated Cognitive-neuroscience Architectures for Understanding Sensemaking (ICArUS

ICARUS mission, next step of coronal exploration after Solar Orbiter and Solar Probe Plus

NASA Astrophysics Data System (ADS)

Krasnoselskikh, Vladimir; Tsurutani, Bruce T.; Velli, Marco; Maksimovic, Milan; Balikhin, Mikhael; Dudok de Wit, Thierry; Kretzschmar, Matthieu

2017-04-01

The primary scientific goal of ICARUS (Investigation of Coronal AcceleRation and heating Up to the Sun), a mother-daughter satellite mission, will be to determine how the magnetic _field and plasma dynamics in the outer solar atmosphere give rise to the corona, the solar wind and the entire heliosphere. Reaching this goal will be a Rosetta-stone step, with results broadly applicable within the fields of space plasma physics and astrophysics. Within ESA's Cosmic Vision roadmap, these science goals address Theme 2: How does the solar system work ?" by investigating basic processes occurring From the Sun to the edge of the Solar System". ICARUS will not only advance our understanding of the plasma environment around our the Sun, but also of the numerous magnetically active stars with hot plasma coronae. ICARUS I will perform the first-ever direct in situ measurements of electromagnetic fields, particle acceleration, wave activity, energy distribution and flows directly in the regions where the solar wind emerges from the coronal plasma. ICARUS I will have a perihelion at 1 Solar radius from its surface, it will cross the region where the major energy deposition occurs. The polar orbit of ICARUS I will enable crossing the regions where both the fast and slow wind are generated. It will probe local characteristics of the plasma and provide unique information about the physical processes involved in the creation of the solar wind. ICARUS II will observe this region using remote-sensing instruments, providing simultaneous information about regions crossed by ICARUS I and the solar atmosphere below as observed by solar telescopes. It will thus provide bridges for understanding the magnetic links between the heliosphere and the solar atmosphere. Such information is crucial to our understanding of the plasma physics and electrodynamics of the solar atmosphere. ICARUS II will also play a very important relay role, enabling the radio-link with ICARUS I. It will receive

Overview of TPC Benchmark E: The Next Generation of OLTP Benchmarks

NASA Astrophysics Data System (ADS)

Hogan, Trish

Set to replace the aging TPC-C, the TPC Benchmark E is the next generation OLTP benchmark, which more accurately models client database usage. TPC-E addresses the shortcomings of TPC-C. It has a much more complex workload, requires the use of RAID-protected storage, generates much less I/O, and is much cheaper and easier to set up, run, and audit. After a period of overlap, it is expected that TPC-E will become the de facto OLTP benchmark.

TPC2 controls pigmentation by regulating melanosome pH and size

PubMed Central

Ambrosio, Andrea L.; Boyle, Judith A.; Aradi, Al E.; Christian, Keith A.; Di Pietro, Santiago M.

2016-01-01

Melanin is responsible for pigmentation of skin and hair and is synthesized in a specialized organelle, the melanosome, in melanocytes. A genome-wide association study revealed that the two pore segment channel 2 (TPCN2) gene is strongly linked to pigmentation variations. TPCN2 encodes the two-pore channel 2 (TPC2) protein, a cation channel. Nevertheless, how TPC2 regulates pigmentation remains unknown. Here, we show that TPC2 is expressed in melanocytes and localizes to the melanosome-limiting membrane and, to a lesser extent, to endolysosomal compartments by confocal fluorescence and immunogold electron microscopy. Immunomagnetic isolation of TPC2-containing organelles confirmed its coresidence with melanosomal markers. TPCN2 knockout by means of clustered regularly interspaced short palindromic repeat/CRISPR-associated 9 gene editing elicited a dramatic increase in pigment content in MNT-1 melanocytic cells. This effect was rescued by transient expression of TPC2-GFP. Consistently, siRNA-mediated knockdown of TPC2 also caused a substantial increase in melanin content in both MNT-1 cells and primary human melanocytes. Using a newly developed genetically encoded pH sensor targeted to melanosomes, we determined that the melanosome lumen in TPC2-KO MNT-1 cells and primary melanocytes subjected to TPC2 knockdown is less acidic than in control cells. Fluorescence and electron microscopy analysis revealed that TPC2-KO MNT-1 cells have significantly larger melanosomes than control cells, but the number of organelles is unchanged. TPC2 likely regulates melanosomes pH and size by mediating Ca2+ release from the organelle, which is decreased in TPC2-KO MNT-1 cells, as determined with the Ca2+ sensor tyrosinase-GCaMP6. Thus, our data show that TPC2 regulates pigmentation through two fundamental determinants of melanosome function: pH and size. PMID:27140606

TPC2 controls pigmentation by regulating melanosome pH and size.

PubMed

Ambrosio, Andrea L; Boyle, Judith A; Aradi, Al E; Christian, Keith A; Di Pietro, Santiago M

2016-05-17

Melanin is responsible for pigmentation of skin and hair and is synthesized in a specialized organelle, the melanosome, in melanocytes. A genome-wide association study revealed that the two pore segment channel 2 (TPCN2) gene is strongly linked to pigmentation variations. TPCN2 encodes the two-pore channel 2 (TPC2) protein, a cation channel. Nevertheless, how TPC2 regulates pigmentation remains unknown. Here, we show that TPC2 is expressed in melanocytes and localizes to the melanosome-limiting membrane and, to a lesser extent, to endolysosomal compartments by confocal fluorescence and immunogold electron microscopy. Immunomagnetic isolation of TPC2-containing organelles confirmed its coresidence with melanosomal markers. TPCN2 knockout by means of clustered regularly interspaced short palindromic repeat/CRISPR-associated 9 gene editing elicited a dramatic increase in pigment content in MNT-1 melanocytic cells. This effect was rescued by transient expression of TPC2-GFP. Consistently, siRNA-mediated knockdown of TPC2 also caused a substantial increase in melanin content in both MNT-1 cells and primary human melanocytes. Using a newly developed genetically encoded pH sensor targeted to melanosomes, we determined that the melanosome lumen in TPC2-KO MNT-1 cells and primary melanocytes subjected to TPC2 knockdown is less acidic than in control cells. Fluorescence and electron microscopy analysis revealed that TPC2-KO MNT-1 cells have significantly larger melanosomes than control cells, but the number of organelles is unchanged. TPC2 likely regulates melanosomes pH and size by mediating Ca(2+) release from the organelle, which is decreased in TPC2-KO MNT-1 cells, as determined with the Ca(2+) sensor tyrosinase-GCaMP6. Thus, our data show that TPC2 regulates pigmentation through two fundamental determinants of melanosome function: pH and size.

Project Icarus: Preliminary Thoughts on the Selection of Probes and Instruments for an Icarus-style Interstellar Mission

NASA Astrophysics Data System (ADS)

Crawford, Ian A.

2016-06-01

In this paper we outline the range of probes and scientific instruments that will be required in order for Icarus to fulfill its scientific mission of exploring a nearby star, its attendant planetary system, and the intervening interstellar medium. Based on this preliminary analysis, we estimate that the minimum total Icarus scientific payload mass (i.e. the mass of probes and instruments which must be decelerated to rest in the target system to enable a meaningful programme of scientific investigation) will be in the region of 100 tonnes. Of this, approximately 10 tonnes would be allocated for cruise-phase science instruments, and about 35 tonnes (i.e. the average of estimated lower and upper limits of 28 and 41 tonnes) would be contributed by the intra-system science payload itself (i.e. the dry mass of the stellar and planetary probes and their instruments). The remaining ~55 tonnes is allocated for the sub-probe intra-system propulsion requirements (crudely estimated from current Solar System missions; detailed modelling of sub-probe propulsion systems will be needed to refine this figure). The overall mass contributed by the science payload to the total that must be decelerated from the interstellar cruise velocity will be considerably more than 100 tonnes, however, as allowance must be made for the payload structural and infrastructural elements required to support, deploy, and communicate with the science probes and instruments. Based on the earlier Daedalus study, we estimate another factor of two to allow for these components. Pending the outcome of more detailed studies, it therefore appears that an overall science-related payload mass of ~200 tonnes will be required. This paper is a submission of the Project Icarus Study Group.

TPC status for MPD experiment of NICA project

NASA Astrophysics Data System (ADS)

Averyanov, A.; Bazhazhin, A.; Chepurnov, V. F.; Chepurnov, V. V.; Cheremukhina, G.; Chernenko, S.; Fateev, O.; Kiriushin, Yu.; Kolesnikov, A.; Korotkova, A.; Levchanovsky, F.; Lukstins, J.; Movchan, S.; Pilyar, A.; Razin, S.; Ribakov, A.; Samsonov, V.; Vereschagin, S.; Zanevsky, Yu.; Zaporozhets, S.; Zruev, V.

2017-06-01

In a frame of the JINR scientific program on study of hot and dense baryonic matter a new accelerator complex Ion Collider fAcility (NICA) based on the Nuclotron-M is under realization. It will operate at luminosity up to 1027 cm-2s-1 for Au79+ ions. Two interaction points are foreseen at NICA for two detectors which will operate simultaneously. One of these detectors, the Multi-Purpose Detector (MPD), is optimized for investigations of heavy-ion collisions. The Time-Projection Chamber (TPC) is the main tracking detector of the MPD central barrel. It is a well-known detector for 3-dimensional tracking and particle identification for high multiplicity events. The conceptual layout of MPD and detailed description of the design and main working parameters of TPC, the readout system based on MWPC and readout electronics as well as the TPC subsystems and tooling for assembling and integration TPC into MPD are presented.

On the cellular site of two-pore channel TPC1 action in the Poaceae.

PubMed

Dadacz-Narloch, Beata; Kimura, Sachie; Kurusu, Takamitsu; Farmer, Edward E; Becker, Dirk; Kuchitsu, Kazuyuki; Hedrich, Rainer

2013-11-01

The slow vacuolar (SV) channel has been characterized in different dicots by patch-clamp recordings. This channel represents the major cation conductance of the largest organelle in most plant cells. Studies with the tpc1-2 mutant of the model dicot plant Arabidopsis thaliana identified the SV channel as the product of the TPC1 gene. By contrast, research on rice and wheat TPC1 suggested that the monocot gene encodes a plasma membrane calcium-permeable channel. To explore the site of action of grass TPC1 channels, we expressed OsTPC1 from rice (Oryza sativa) and TaTPC1 from wheat (Triticum aestivum) in the background of the Arabidopsis tpc1-2 mutant. Cross-species tpc1 complementation and patch-clamping of vacuoles using Arabidopsis and rice tpc1 null mutants documented that both monocot TPC1 genes were capable of rescuing the SV channel deficit. Vacuoles from wild-type rice but not the tpc1 loss-of-function mutant harbor SV channels exhibiting the hallmark properties of dicot TPC1/SV channels. When expressed in human embryonic kidney (HEK293) cells OsTPC1 was targeted to Lysotracker-Red-positive organelles. The finding that the rice TPC1, just like those from the model plant Arabidopsis and even animal cells, is localized and active in lyso-vacuolar membranes associates this cation channel species with endomembrane function. © 2013 The Authors. New Phytologist © 2013 New Phytologist Trust.

MICROMEGAS calibration for ACTAR TPC

NASA Astrophysics Data System (ADS)

Mauss, B.; Roger, T.; Pancin, J.; Damoy, S.; Grinyer, G. F.

2018-02-01

Active targets, such as the ACtive TARget and Time Projection Chamber (ACTAR TPC) being developed at GANIL, are detection systems that operate on the basis of a time projection chamber but where the filling gas also serves as a thick target for nuclear reactions. In nuclear physics experiments, the energy resolution is of primary importance to identify the reaction products and to precisely reconstruct level schemes of nuclei. These measurements are based on the energy deposited on a pixelated pad plane. A MICROMEGAS detector is used in ACTAR TPC for the ionization electron collection and amplification, and it is a major contributor to the energy dispersion through, for example, inhomogeneities of the amplification gap. A variation of one percent in the gap can lead to an amplitude variation of more than two percent which is of the same order as the resolution obtained with an energy deposition of 5 MeV. One way to calibrate the pad plane is through the use of a two dimensional source scanning table. It is used to calibrate the gain inhomogeneities and, using MAGBOLTZ calculations, deduce the corresponding gap variations. The inverse of this method would allow the relative gain variations to be calculated for the different gas mixtures and pressures used in experiments with ACTAR TPC.

DarkSide-20k: A 20 Tonne Two-Phase LAr TPC for Direct Dark Matter Detection at LNGS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aalseth, C.E.; et al.

Building on the successful experience in operating the DarkSide-50 detector, the DarkSide Collaboration is going to construct DarkSide-20k, a direct WIMP search detector using a two-phase Liquid Argon Time Projection Chamber (LArTPC) with an active (fiducial) mass of 23 t (20 t). The DarkSide-20k LArTPC will be deployed within a shield/veto with a spherical Liquid Scintillator Veto (LSV) inside a cylindrical Water Cherenkov Veto (WCV). Operation of DarkSide-50 demonstrated a major reduction in the dominantmore » $$^{39}$$Ar background when using argon extracted from an underground source, before applying pulse shape analysis. Data from DarkSide-50, in combination with MC simulation and analytical modeling, shows that a rejection factor for discrimination between electron and nuclear recoils of $$\\gt3\\times10^9$$ is achievable. This, along with the use of the veto system, is the key to unlocking the path to large LArTPC detector masses, while maintaining an "instrumental background-free" experiment, an experiment in which less than 0.1 events (other than $$\

A streamlined Python framework for AT-TPC data analysis

NASA Astrophysics Data System (ADS)

Taylor, J. Z.; Bradt, J.; Bazin, D.; Kuchera, M. P.

2017-09-01

User-friendly data analysis software has been developed for the Active-Target Time Projection Chamber (AT-TPC) experiment at the National Superconducting Cyclotron Laboratory at Michigan State University. The AT-TPC, commissioned in 2014, is a gas-filled detector that acts as both the detector and target for high-efficiency detection of low-intensity, exotic nuclear reactions. The pytpc framework is a Python package for analyzing AT-TPC data. The package was developed for the analysis of 46Ar(p, p) data. The existing software was used to analyze data produced by the 40Ar(p, p) experiment that ran in August, 2015. Usage of the package was documented in an analysis manual both to improve analysis steps and aid in the work of future AT-TPC users. Software features and analysis methods in the pytpc framework will be presented along with the 40Ar results.

Overview of the data analysis and new micro-pattern gas detector development for the Active Target Time Projection Chamber (AT-TPC) project.

NASA Astrophysics Data System (ADS)

Ayyad, Yassid; Mittig, Wolfgang; Bazin, Daniel; Cortesi, Marco

2017-07-01

The Active Target Time Projection Chamber (AT-TPC) project at the NSCL (National Superconducting Cyclotron Laboratory, Michigan State University) is a novel active target detector tailored for low-energy nuclear reactions in inverse kinematics with radioactive ion beams. The AT-TPC allows for a full three dimensional reconstruction of the reaction and provides high luminosity without degradation of resolution by the thickness of the target. Since all the particles (and also the reaction vertex) are tracked inside the detector, the AT-TPC has full 4π efficiency. The AT-TPC can operate under a magnetic field (2 T) that improves the identification of the particles and the energy resolution through the measurement of the magnetic rigidity. Another important characteristic of the AT-TPC is the high-gain operation achieved by the hybrid thick Gas Electron Multipliers (THGEM)-Micromegas pad plane, that allow operation also in pure elemental gas. These two features make the AT-TPC a unique high resolution spectrometer with full acceptance for nuclear physics reactions. This work presents an overview of the project, focused on the data analysis and the development of new micro-pattern gas detectors.

MWPC prototyping and performance test for the STAR inner TPC upgrade

NASA Astrophysics Data System (ADS)

Shen, Fuwang; Wang, Shuai; Kong, Fangang; Bai, Shiwei; Li, Changyu; Videbæk, Flemming; Xu, Zhangbu; Zhu, Chengguang; Xu, Qinghua; Yang, Chi

2018-07-01

A new prototype of STAR inner Time Projection Chamber (iTPC) MWPC sector has been fabricated and tested in an X-ray test system. The wire chamber built at Shandong University has a wire tension precision better than 6% and wire pitch precision better than 10 μm. The gas gain uniformity and energy resolution are measured to be better than 1% (RMS) and 20% (FWHM), respectively, using an 55Fe X-ray source. The iTPC upgrade project is to replace all 24 STAR TPC inner sectors as a crucial detector upgrade for the RHIC beam energy scan phase II program. The test results show that the constructed iTPC prototype meets all project requirements.

DarkSide-20k: A 20 tonne two-phase LAr TPC for direct dark matter detection at LNGS

NASA Astrophysics Data System (ADS)

Aalseth, C. E.; Acerbi, F.; Agnes, P.; Albuquerque, I. F. M.; Alexander, T.; Alici, A.; Alton, A. K.; Antonioli, P.; Arcelli, S.; Ardito, R.; Arnquist, I. J.; Asner, D. M.; Ave, M.; Back, H. O.; Barrado Olmedo, A. I.; Batignani, G.; Bertoldo, E.; Bettarini, S.; Bisogni, M. G.; Bocci, V.; Bondar, A.; Bonfini, G.; Bonivento, W.; Bossa, M.; Bottino, B.; Boulay, M.; Bunker, R.; Bussino, S.; Buzulutskov, A.; Cadeddu, M.; Cadoni, M.; Caminata, A.; Canci, N.; Candela, A.; Cantini, C.; Caravati, M.; Cariello, M.; Carlini, M.; Carpinelli, M.; Castellani, A.; Catalanotti, S.; Cataudella, V.; Cavalcante, P.; Cavuoti, S.; Cereseto, R.; Chepurnov, A.; Cicalò, C.; Cifarelli, L.; Citterio, M.; Cocco, A. G.; Colocci, M.; Corgiolu, S.; Covone, G.; Crivelli, P.; D'Antone, I.; D'Incecco, M.; D'Urso, D.; Da Rocha Rolo, M. D.; Daniel, M.; Davini, S.; de Candia, A.; De Cecco, S.; De Deo, M.; De Filippis, G.; De Guido, G.; De Rosa, G.; Dellacasa, G.; Della Valle, M.; Demontis, P.; Derbin, A.; Devoto, A.; Di Eusanio, F.; Di Pietro, G.; Dionisi, C.; Dolgov, A.; Dormia, I.; Dussoni, S.; Empl, A.; Fernandez Diaz, M.; Ferri, A.; Filip, C.; Fiorillo, G.; Fomenko, K.; Franco, D.; Froudakis, G. E.; Gabriele, F.; Gabrieli, A.; Galbiati, C.; Garcia Abia, P.; Gendotti, A.; Ghisi, A.; Giagu, S.; Giampa, P.; Gibertoni, G.; Giganti, C.; Giorgi, M. A.; Giovanetti, G. K.; Gligan, M. L.; Gola, A.; Gorchakov, O.; Goretti, A. M.; Granato, F.; Grassi, M.; Grate, J. W.; Grigoriev, G. Y.; Gromov, M.; Guan, M.; Guerra, M. B. B.; Guerzoni, M.; Gulino, M.; Haaland, R. K.; Hallin, A.; Harrop, B.; Hoppe, E. W.; Horikawa, S.; Hosseini, B.; Hughes, D.; Humble, P.; Hungerford, E. V.; Ianni, An.; Jillings, C.; Johnson, T. N.; Keeter, K.; Kendziora, C. L.; Kim, S.; Koh, G.; Korablev, D.; Korga, G.; Kubankin, A.; Kuss, M.; Kuźniak, M.; La Commara, M.; Lehnert, B.; Li, X.; Lissia, M.; Lodi, G. U.; Loer, B.; Longo, G.; Loverre, P.; Lussana, R.; Luzzi, L.; Ma, Y.; Machado, A. A.; Machulin, I. N.; Mandarano, A.; Mapelli, L.; Marcante, M.; Margotti, A.; Mari, S. M.; Mariani, M.; Maricic, J.; Martoff, C. J.; Mascia, M.; Mayer, M.; McDonald, A. B.; Messina, A.; Meyers, P. D.; Milincic, R.; Moggi, A.; Moioli, S.; Monroe, J.; Monte, A.; Morrocchi, M.; Mount, B. J.; Mu, W.; Muratova, V. N.; Murphy, S.; Musico, P.; Nania, R.; Navrer Agasson, A.; Nikulin, I.; Nosov, V.; Nozdrina, A. O.; Nurakhov, N. N.; Oleinik, A.; Oleynikov, V.; Orsini, M.; Ortica, F.; Pagani, L.; Pallavicini, M.; Palmas, S.; Pandola, L.; Pantic, E.; Paoloni, E.; Paternoster, G.; Pavletcov, V.; Pazzona, F.; Peeters, S.; Pelczar, K.; Pellegrini, L. A.; Pelliccia, N.; Perotti, F.; Perruzza, R.; Pesudo, V.; Piemonte, C.; Pilo, F.; Pocar, A.; Pollmann, T.; Portaluppi, D.; Pugachev, D. A.; Qian, H.; Radics, B.; Raffaelli, F.; Ragusa, F.; Razeti, M.; Razeto, A.; Regazzoni, V.; Regenfus, C.; Reinhold, B.; Renshaw, A. L.; Rescigno, M.; Retière, F.; Riffard, Q.; Rivetti, A.; Rizzardini, S.; Romani, A.; Romero, L.; Rossi, B.; Rossi, N.; Rubbia, A.; Sablone, D.; Salatino, P.; Samoylov, O.; Sánchez García, E.; Sands, W.; Sanfilippo, S.; Sant, M.; Santorelli, R.; Savarese, C.; Scapparone, E.; Schlitzer, B.; Scioli, G.; Segreto, E.; Seifert, A.; Semenov, D. A.; Shchagin, A.; Shekhtman, L.; Shemyakina, E.; Sheshukov, A.; Simeone, M.; Singh, P. N.; Skensved, P.; Skorokhvatov, M. D.; Smirnov, O.; Sobrero, G.; Sokolov, A.; Sotnikov, A.; Speziale, F.; Stainforth, R.; Stanford, C.; Suffritti, G. B.; Suvorov, Y.; Tartaglia, R.; Testera, G.; Tonazzo, A.; Tosi, A.; Trinchese, P.; Unzhakov, E. V.; Vacca, A.; Vázquez-Jáuregui, E.; Verducci, M.; Viant, T.; Villa, F.; Vishneva, A.; Vogelaar, B.; Wada, M.; Wahl, J.; Walding, J.; Wang, H.; Wang, Y.; Watson, A. W.; Westerdale, S.; Williams, R.; Wojcik, M. M.; Wu, S.; Xiang, X.; Xiao, X.; Yang, C.; Ye, Z.; Yllera de Llano, A.; Zappa, F.; Zappalà, G.; Zhu, C.; Zichichi, A.; Zullo, M.; Zullo, A.; Zuzel, G.

2018-03-01

Building on the successful experience in operating the DarkSide-50 detector, the DarkSide Collaboration is going to construct DarkSide-20k, a direct WIMP search detector using a two-phase Liquid Argon Time Projection Chamber (LAr TPC) with an active (fiducial) mass of 23 t (20 t). This paper describes a preliminary design for the experiment, in which the DarkSide-20k LAr TPC is deployed within a shield/veto with a spherical Liquid Scintillator Veto (LSV) inside a cylindrical Water Cherenkov Veto (WCV). This preliminary design provides a baseline for the experiment to achieve its physics goals, while further development work will lead to the final optimization of the detector parameters and an eventual technical design. Operation of DarkSide-50 demonstrated a major reduction in the dominant 39Ar background when using argon extracted from an underground source, before applying pulse shape analysis. Data from DarkSide-50, in combination with MC simulation and analytical modeling, shows that a rejection factor for discrimination between electron and nuclear recoils of >3 × 109 is achievable. This, along with the use of the veto system and utilizing silicon photomultipliers in the LAr TPC, are the keys to unlocking the path to large LAr TPC detector masses, while maintaining an experiment in which less than < 0.1 events (other than ν-induced nuclear recoils) is expected to occur within the WIMP search region during the planned exposure. DarkSide-20k will have ultra-low backgrounds than can be measured in situ, giving sensitivity to WIMP-nucleon cross sections of 1.2 × 10^{-47} cm2 (1.1 × 10^{-46} cm2) for WIMPs of 1 TeV/c 2 (10 TeV/c 2) mass, to be achieved during a 5 yr run producing an exposure of 100 t yr free from any instrumental background.

MWPC prototyping and performance test for the STAR inner TPC upgrade

DOE PAGES

Shen, Fuwang; Wang, Shuai; Kong, Fangang; ...

2018-04-16

A new prototype of STAR inner Time Projection Chamber (iTPC) MWPC sector has been fabricated and tested in an X-ray test system. The wire chamber built at Shandong University has a wire tension precision better than 6% and wire pitch precision better than 10 μm. The gas gain uniformity and energy resolution are measured to be better than 1% (RMS) and 20% (FWHM), respectively, using an 55Fe X-ray source. The iTPC upgrade project is to replace all 24 STAR TPC inner sectors as a crucial detector upgrade for the RHIC beam energy scan phase II program. Furthermore, the test resultsmore » show that the constructed iTPC prototype meets all project requirements.« less

MWPC prototyping and performance test for the STAR inner TPC upgrade

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shen, Fuwang; Wang, Shuai; Kong, Fangang

A new prototype of STAR inner Time Projection Chamber (iTPC) MWPC sector has been fabricated and tested in an X-ray test system. The wire chamber built at Shandong University has a wire tension precision better than 6% and wire pitch precision better than 10 μm. The gas gain uniformity and energy resolution are measured to be better than 1% (RMS) and 20% (FWHM), respectively, using an 55Fe X-ray source. The iTPC upgrade project is to replace all 24 STAR TPC inner sectors as a crucial detector upgrade for the RHIC beam energy scan phase II program. Furthermore, the test resultsmore » show that the constructed iTPC prototype meets all project requirements.« less

Two Pore Channel 2 (TPC2) Inhibits Autophagosomal-Lysosomal Fusion by Alkalinizing Lysosomal pH*

PubMed Central

Lu, Yingying; Hao, Bai-Xia; Graeff, Richard; Wong, Connie W. M.; Wu, Wu-Tian; Yue, Jianbo

2013-01-01

Autophagy is an evolutionarily conserved lysosomal degradation pathway, yet the underlying mechanisms remain poorly understood. Nicotinic acid adenine dinucleotide phosphate (NAADP), one of the most potent Ca2+ mobilizing messengers, elicits Ca2+ release from lysosomes via the two pore channel 2 (TPC2) in many cell types. Here we found that overexpression of TPC2 in HeLa or mouse embryonic stem cells inhibited autophagosomal-lysosomal fusion, thereby resulting in the accumulation of autophagosomes. Treatment of TPC2 expressing cells with a cell permeant-NAADP agonist, NAADP-AM, further induced autophagosome accumulation. On the other hand, TPC2 knockdown or treatment of cells with Ned-19, a NAADP antagonist, markedly decreased the accumulation of autophagosomes. TPC2-induced accumulation of autophagosomes was also markedly blocked by ATG5 knockdown. Interestingly, inhibiting mTOR activity failed to increase TPC2-induced autophagosome accumulation. Instead, we found that overexpression of TPC2 alkalinized lysosomal pH, and lysosomal re-acidification abolished TPC2-induced autophagosome accumulation. In addition, TPC2 overexpression had no effect on general endosomal-lysosomal degradation but prevented the recruitment of Rab-7 to autophagosomes. Taken together, our data demonstrate that TPC2/NAADP/Ca2+ signaling alkalinizes lysosomal pH to specifically inhibit the later stage of basal autophagy progression. PMID:23836916

Integrated Cognitive-neuroscience Architectures for Understanding Sensemaking (ICArUS): Phase 1 Test and Evaluation Development Guide

DTIC Science & Technology

2014-11-01

Integrated Cognitive-neuroscience Architectures for Understanding Sensemaking (ICArUS): Phase 1 Test and Evaluation Development Guide Craig...Self-initiated sensemaking ........................................................................................... 19 Feature Vector Format: Tasks...The Integrated Cognitive-neuroscience Architectures for Understanding Sensemaking (ICArUS) Program aimed to build computational cognitive

A large ungated TPC with GEM amplification

NASA Astrophysics Data System (ADS)

Berger, M.; Ball, M.; Fabbietti, L.; Ketzer, B.; Arora, R.; Beck, R.; Böhmer, F. V.; Chen, J.-C.; Cusanno, F.; Dørheim, S.; García, F.; Hehner, J.; Herrmann, N.; Höppner, C.; Kaiser, D.; Kis̆, M.; Kleipa, V.; Konorov, I.; Kunkel, J.; Kurz, N.; Leifels, Y.; Müllner, P.; Münzer, R.; Neubert, S.; Rauch, J.; Schmidt, C. J.; Schmitz, R.; Soyk, D.; Vandenbroucke, M.; Voss, B.; Walther, D.; Zmeskal, J.

2017-10-01

A Time Projection Chamber (TPC) is an ideal device for the detection of charged particle tracks in a large volume covering a solid angle of almost 4 π. The high density of hits on a given particle track facilitates the task of pattern recognition in a high-occupancy environment and in addition provides particle identification by measuring the specific energy loss for each track. For these reasons, TPCs with Multiwire Proportional Chamber (MWPC) amplification have been and are widely used in experiments recording heavy-ion collisions. A significant drawback, however, is the large dead time of the order of 1 ms per event generated by the use of a gating grid, which is mandatory to prevent ions created in the amplification region from drifting back into the drift volume, where they would severely distort the drift path of subsequent tracks. For experiments with higher event rates this concept of a conventional TPC operating with a triggered gating grid can therefore not be applied without a significant loss of data. A continuous readout of the signals is the more appropriate way of operation. This, however, constitutes a change of paradigm with considerable challenges to be met concerning the amplification region, the design and bandwidth of the readout electronics, and the data handling. A mandatory prerequisite for such an operation is a sufficiently good suppression of the ion backflow from the avalanche region, which otherwise limits the tracking and particle identification capabilities of such a detector. Gas Electron Multipliers (GEM) are a promising candidate to combine excellent spatial resolution with an intrinsic suppression of ions. In this paper we describe the design, construction and the commissioning of a large TPC with GEM amplification and without gating grid (GEM-TPC). The design requirements have driven innovations in the construction of a light-weight field-cage, a supporting media flange, the GEM amplification and the readout system, which are

Project Icarus: Analysis of Plasma jet driven Magneto-Inertial Fusion as potential primary propulsion driver for the Icarus probe

NASA Astrophysics Data System (ADS)

Stanic, M.; Cassibry, J. T.; Adams, R. B.

2013-05-01

Hopes of sending probes to another star other than the Sun are currently limited by the maturity of advanced propulsion technologies. One of the few candidate propulsion systems for providing interstellar flight capabilities is nuclear fusion. In the past many fusion propulsion concepts have been proposed and some of them have even been explored in detail, Project Daedalus for example. However, as scientific progress in this field has advanced, new fusion concepts have emerged that merit evaluation as potential drivers for interstellar missions. Plasma jet driven Magneto-Inertial Fusion (PJMIF) is one of those concepts. PJMIF involves a salvo of converging plasma jets that form a uniform liner, which compresses a magnetized target to fusion conditions. It is an Inertial Confinement Fusion (ICF)-Magnetic Confinement Fusion (MCF) hybrid approach that has the potential for a multitude of benefits over both ICF and MCF, such as lower system mass and significantly lower cost. This paper concentrates on a thermodynamic assessment of basic performance parameters necessary for utilization of PJMIF as a candidate propulsion system for the Project Icarus mission. These parameters include: specific impulse, thrust, exhaust velocity, mass of the engine system, mass of the fuel required etc. This is a submission of the Project Icarus Study Group.

Icarus Investigations: A Model for Engaging Citizen Scientists to Solve Solar Big Data Challenges

NASA Astrophysics Data System (ADS)

Winter, H. D., III; Loftus, K.

2017-12-01

Solar data is growing at an exponential rate. NASA's Atmospheric Imaging Assembly (AIA) has produced a data volume of over 6 petabytes to date, and that volume is growing. The initial suite of instruments on DKIST are expected to generate approximately 25TB of data per day, with bursts up to 50TB. Making sense of this deluge of solar data is as formidable a task as collecting it. New techniques and new ways of thinking are needed in order to optimize the value of this immense amount of data. While machine learning algorithms are a natural tool to sift through Big Data, those tools need to be carefully constructed and trained in order to provide meaningful results. Trained volunteers are needed to provide a large volume of initial classifications in order to properly train machine learning algorithms. To retain a highly trained pool of volunteers to teach machine learning algorithms, we propose to host an ever-changing array of solar-based citizen science projects under a single collaborative project banner: Icarus Investigations. Icarus Investigations would build and retain a dedicated user base within Zooniverse, the most popular citizen science website with over a million registered users. Volunteers will become increasingly comfortable with solar images and solar features of interest as they work on projects that focus on a wide array of solar phenomena. Under a unified framework, new solar citizen science projects submitted to Icarus Investigations will build on the successes, and learn from the missteps, of their predecessors. In this talk we discuss the importance and benefits of engaging the public in citizen science projects and call for collaborators on future citizen science projects. We will also demonstrate the initial Icarus Investigations project, The Where of the Flare. This demonstration will allow us to highlight the workflow of a Icarus Investigations citizen science project with a concrete example.

Fission cross section uncertainties with the NIFFTE TPC

NASA Astrophysics Data System (ADS)

Sangiorgio, Samuele; Niffte Collaboration

2014-09-01

Nuclear data such as neutron-induced fission cross sections play a fundamental role in nuclear energy and defense applications. In recent years, understanding of these systems has become increasingly dependent upon advanced simulation and modeling, where uncertainties in nuclear data propagate in the expected performances of existing and future systems. It is important therefore that uncertainties in nuclear data are minimized and fully understood. For this reason, the Neutron Induced Fission Fragment Tracking Experiment (NIFFTE) uses a Time Projection Chamber (TPC) to measure energy-differential (n,f) cross sections with unprecedented precision. The presentation will discuss how the capabilities of the NIFFTE TPC allow to directly measures systematic uncertainties in fission cross sections, in particular for what concerns fission-fragment identification, and target and beam uniformity. Preliminary results from recent analysis of 238U/235U and 239Pu/235U data collected with the TPC will be presented. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

Slow Control System for the NIFFTE Collaboration TPC

NASA Astrophysics Data System (ADS)

Ringle, Erik; Niffte Collaboration Collaboration

2011-10-01

As world energy concerns continue to dominate public policy in the 21st century, the need for cleaner and more efficient nuclear power is necessary. In order to effectively design and implement plans for generation IV nuclear reactors, more accurate fission cross-section measurements are necessary. The Neutron Induced Fission Fragment Tracking Experiment (NIFFTE) collaboration, in an effort to meet this need, has constructed a Time Projection Chamber (TPC) which aims to reduce the uncertainty of the fission cross-section to less than 1%. Using the Maximum Integration Data Acquisition System (MIDAS) framework, slow control measurements are integrated into a single interface to facilitate off-site monitoring. The Hart Scientific 1560 Black Stack will be used with two 2564 Thermistor Scanner Modules to monitor internal temperature of the TPC. A Prologix GPIB to Ethernet controller will be used to interface the hardware with MIDAS. This presentation will detail the design and implementation of the slow control system for the TPC. This work was supported by the U.S. Department of Energy Division of Energy Research.

Front-end electronics development for TPC detector in the MPD/NICA project

NASA Astrophysics Data System (ADS)

Cheremukhina, G.; Movchan, S.; Vereschagin, S.; Zaporozhets, S.

2017-06-01

The article is aimed at describing the development status, measuring results and design changes of the TPC front-end electronics. The TPC is placed in the middle of Multi-Purpose Detector (MPD) and provides tracing and identifying of charged particles in the pseudorapidity range |η| < 1.2. The readout system is one of the most complex parts of the TPC. The electronics of each readout chamber is an independent system. The whole system contains 95232 channels, 1488 64-channel—front-end cards (FEC), 24 readout control units (RCU). The front-end electronics (FEE) is based on ASICs, FPGAs and high-speed serial links. The concept of the TPC front-end electronics has been motivated from one side—by the requirements concerning the NICA accelerator complex which will operate at the luminosity up to 1027 cm-2 s-1 for Au79+ ions over the energy range of 4 < √SNN < 11 GeV with the trigger rate up to 7 kHz and from the other side—by the requirements of the 4-π geometry to minimize the substance on the end-caps of the TPC.

The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation

PubMed Central

Lin-Moshier, Yaping; Keebler, Michael V.; Hooper, Robert; Boulware, Michael J.; Liu, Xiaolong; Churamani, Dev; Abood, Mary E.; Walseth, Timothy F.; Brailoiu, Eugen; Patel, Sandip; Marchant, Jonathan S.

2014-01-01

The two-pore channels (TPC1 and TPC2) belong to an ancient family of intracellular ion channels expressed in the endolysosomal system. Little is known about how regulatory inputs converge to modulate TPC activity, and proposed activation mechanisms are controversial. Here, we compiled a proteomic characterization of the human TPC interactome, which revealed that TPCs complex with many proteins involved in Ca2+ homeostasis, trafficking, and membrane organization. Among these interactors, TPCs were resolved to scaffold Rab GTPases and regulate endomembrane dynamics in an isoform-specific manner. TPC2, but not TPC1, caused a proliferation of endolysosomal structures, dysregulating intracellular trafficking, and cellular pigmentation. These outcomes required both TPC2 and Rab activity, as well as their interactivity, because TPC2 mutants that were inactive, or rerouted away from their endogenous expression locale, or deficient in Rab binding, failed to replicate these outcomes. Nicotinic acid adenine dinucleotide phosphate (NAADP)-evoked Ca2+ release was also impaired using either a Rab binding-defective TPC2 mutant or a Rab inhibitor. These data suggest a fundamental role for the ancient TPC complex in trafficking that holds relevance for lysosomal proliferative scenarios observed in disease. PMID:25157141

The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation.

PubMed

Lin-Moshier, Yaping; Keebler, Michael V; Hooper, Robert; Boulware, Michael J; Liu, Xiaolong; Churamani, Dev; Abood, Mary E; Walseth, Timothy F; Brailoiu, Eugen; Patel, Sandip; Marchant, Jonathan S

2014-09-09

The two-pore channels (TPC1 and TPC2) belong to an ancient family of intracellular ion channels expressed in the endolysosomal system. Little is known about how regulatory inputs converge to modulate TPC activity, and proposed activation mechanisms are controversial. Here, we compiled a proteomic characterization of the human TPC interactome, which revealed that TPCs complex with many proteins involved in Ca(2+) homeostasis, trafficking, and membrane organization. Among these interactors, TPCs were resolved to scaffold Rab GTPases and regulate endomembrane dynamics in an isoform-specific manner. TPC2, but not TPC1, caused a proliferation of endolysosomal structures, dysregulating intracellular trafficking, and cellular pigmentation. These outcomes required both TPC2 and Rab activity, as well as their interactivity, because TPC2 mutants that were inactive, or rerouted away from their endogenous expression locale, or deficient in Rab binding, failed to replicate these outcomes. Nicotinic acid adenine dinucleotide phosphate (NAADP)-evoked Ca(2+) release was also impaired using either a Rab binding-defective TPC2 mutant or a Rab inhibitor. These data suggest a fundamental role for the ancient TPC complex in trafficking that holds relevance for lysosomal proliferative scenarios observed in disease.

Lysosomal Two-pore Channel Subtype 2 (TPC2) Regulates Skeletal Muscle Autophagic Signaling*

PubMed Central

Lin, Pei-Hui; Duann, Pu; Komazaki, Shinji; Park, Ki Ho; Li, Haichang; Sun, Mingzhai; Sermersheim, Mathew; Gumpper, Kristyn; Parrington, John; Galione, Antony; Evans, A. Mark; Zhu, Michael X.; Ma, Jianjie

2015-01-01

Postnatal skeletal muscle mass is regulated by the balance between anabolic protein synthesis and catabolic protein degradation, and muscle atrophy occurs when protein homeostasis is disrupted. Autophagy has emerged as critical in clearing dysfunctional organelles and thus in regulating protein turnover. Here we show that endolysosomal two-pore channel subtype 2 (TPC2) contributes to autophagy signaling and protein homeostasis in skeletal muscle. Muscles derived from Tpcn2−/− mice exhibit an atrophic phenotype with exacerbated autophagy under starvation. Compared with wild types, animals lacking TPC2 demonstrated an enhanced autophagy flux characterized by increased accumulation of autophagosomes upon combined stress induction by starvation and colchicine treatment. In addition, deletion of TPC2 in muscle caused aberrant lysosomal pH homeostasis and reduced lysosomal protease activity. Association between mammalian target of rapamycin and TPC2 was detected in skeletal muscle, allowing for appropriate adjustments to cellular metabolic states and subsequent execution of autophagy. TPC2 therefore impacts mammalian target of rapamycin reactivation during the process of autophagy and contributes to maintenance of muscle homeostasis. PMID:25480788

Noise Characterization and Filtering in the MicroBooNE Liquid Argon TPC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Acciarri, R.; et al.

The low-noise operation of readout electronics in a liquid argon time projection chamber (LArTPC) is critical to properly extract the distribution of ionization charge deposited on the wire planes of the TPC, especially for the induction planes. This paper describes the characteristics and mitigation of the observed noise in the MicroBooNE detector. The MicroBooNE's single-phase LArTPC comprises two induction planes and one collection sense wire plane with a total of 8256 wires. Current induced on each TPC wire is amplified and shaped by custom low-power, low-noise ASICs immersed in the liquid argon. The digitization of the signal waveform occurs outsidemore » the cryostat. Using data from the first year of MicroBooNE operations, several excess noise sources in the TPC were identified and mitigated. The residual equivalent noise charge (ENC) after noise filtering varies with wire length and is found to be below 400 electrons for the longest wires (4.7 m). The response is consistent with the cold electronics design expectations and is found to be stable with time and uniform over the functioning channels. This noise level is significantly lower than previous experiments utilizing warm front-end electronics.« less

Noise Characterization and Filtering in the MicroBooNE Liquid Argon TPC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Acciarri, R.; Adams, C.; An, R.

The low-noise operation of readout electronics in a liquid argon time projection chamber (LArTPC) is critical to properly extract the distribution of ionization charge deposited on the wire planes of the TPC, especially for the induction planes. This paper describes the characteristics and mitigation of the observed noise in the MicroBooNE detector. The MicroBooNE's single-phase LArTPC comprises two induction planes and one collection sense wire plane with a total of 8256 wires. Current induced on each TPC wire is amplified and shaped by custom low-power, low-noise ASICs immersed in the liquid argon. The digitization of the signal waveform occurs outsidemore » the cryostat. Using data from the first year of MicroBooNE operations, several excess noise sources in the TPC were identified and mitigated. The residual equivalent noise charge (ENC) after noise filtering varies with wire length and is found to be below 400 electrons for the longest wires (4.7 m). The response is consistent with the cold electronics design expectations and is found to be stable with time and uniform over the functioning channels. In conclusion, this noise level is significantly lower than previous experiments utilizing warm front-end electronics.« less

Noise Characterization and Filtering in the MicroBooNE Liquid Argon TPC

NASA Astrophysics Data System (ADS)

Acciarri, R.; Adams, C.; An, R.; Anthony, J.; Asaadi, J.; Auger, M.; Bagby, L.; Balasubramanian, S.; Baller, B.; Barnes, C.; Barr, G.; Bass, M.; Bay, F.; Bishai, M.; Blake, A.; Bolton, T.; Bullard, B.; Camilleri, L.; Caratelli, D.; Carls, B.; Castillo Fernandez, R.; Cavanna, F.; Chen, H.; Church, E.; Cianci, D.; Cohen, E.; Collin, G. H.; Conrad, J. M.; Convery, M.; Crespo-Anadón, J. I.; De Geronimo, G.; Del Tutto, M.; Devitt, D.; Dytman, S.; Eberly, B.; Ereditato, A.; Escudero Sanchez, L.; Esquivel, J.; Fadeeva, A. A.; Fleming, B. T.; Foreman, W.; Furmanski, A. P.; Garcia-Gamez, D.; Garvey, G. T.; Genty, V.; Goeldi, D.; Gollapinni, S.; Graf, N.; Gramellini, E.; Greenlee, H.; Grosso, R.; Guenette, R.; Hackenburg, A.; Hamilton, P.; Hen, O.; Hewes, J.; Hill, C.; Ho, J.; Horton-Smith, G.; Hourlier, A.; Huang, E.-C.; James, C.; de Vries, J. Jan; Jen, C.-M.; Jiang, L.; Johnson, R. A.; Joshi, J.; Jostlein, H.; Kaleko, D.; Karagiorgi, G.; Ketchum, W.; Kirby, B.; Kirby, M.; Kobilarcik, T.; Kreslo, I.; Laube, A.; Li, S.; Li, Y.; Lister, A.; Littlejohn, B. R.; Lockwitz, S.; Lorca, D.; Louis, W. C.; Luethi, M.; Lundberg, B.; Luo, X.; Marchionni, A.; Mariani, C.; Marshall, J.; Martinez Caicedo, D. A.; Meddage, V.; Miceli, T.; Mills, G. B.; Moon, J.; Mooney, M.; Moore, C. D.; Mousseau, J.; Murrells, R.; Naples, D.; Nienaber, P.; Nowak, J.; Palamara, O.; Paolone, V.; Papavassiliou, V.; Pate, S. F.; Pavlovic, Z.; Piasetzky, E.; Porzio, D.; Pulliam, G.; Qian, X.; Raaf, J. L.; Radeka, V.; Rafique, A.; Rescia, S.; Rochester, L.; von Rohr, C. Rudolf; Russell, B.; Schmitz, D. W.; Schukraft, A.; Seligman, W.; Shaevitz, M. H.; Sinclair, J.; Smith, A.; Snider, E. L.; Soderberg, M.; Söldner-Rembold, S.; Soleti, S. R.; Spentzouris, P.; Spitz, J.; St. John, J.; Strauss, T.; Szelc, A. M.; Tagg, N.; Terao, K.; Thomson, M.; Thorn, C.; Toups, M.; Tsai, Y.-T.; Tufanli, S.; Usher, T.; Van De Pontseele, W.; Van de Water, R. G.; Viren, B.; Weber, M.; Wickremasinghe, D. A.; Wolbers, S.; Wongjirad, T.; Woodruff, K.; Yang, T.; Yates, L.; Yu, B.; Zeller, G. P.; Zennamo, J.; Zhang, C.

2017-08-01

The low-noise operation of readout electronics in a liquid argon time projection chamber (LArTPC) is critical to properly extract the distribution of ionization charge deposited on the wire planes of the TPC, especially for the induction planes. This paper describes the characteristics and mitigation of the observed noise in the MicroBooNE detector. The MicroBooNE's single-phase LArTPC comprises two induction planes and one collection sense wire plane with a total of 8256 wires. Current induced on each TPC wire is amplified and shaped by custom low-power, low-noise ASICs immersed in the liquid argon. The digitization of the signal waveform occurs outside the cryostat. Using data from the first year of MicroBooNE operations, several excess noise sources in the TPC were identified and mitigated. The residual equivalent noise charge (ENC) after noise filtering varies with wire length and is found to be below 400 electrons for the longest wires (4.7 m). The response is consistent with the cold electronics design expectations and is found to be stable with time and uniform over the functioning channels. This noise level is significantly lower than previous experiments utilizing warm front-end electronics.

Noise Characterization and Filtering in the MicroBooNE Liquid Argon TPC

DOE PAGES

Acciarri, R.; Adams, C.; An, R.; ...

2017-08-04

The low-noise operation of readout electronics in a liquid argon time projection chamber (LArTPC) is critical to properly extract the distribution of ionization charge deposited on the wire planes of the TPC, especially for the induction planes. This paper describes the characteristics and mitigation of the observed noise in the MicroBooNE detector. The MicroBooNE's single-phase LArTPC comprises two induction planes and one collection sense wire plane with a total of 8256 wires. Current induced on each TPC wire is amplified and shaped by custom low-power, low-noise ASICs immersed in the liquid argon. The digitization of the signal waveform occurs outsidemore » the cryostat. Using data from the first year of MicroBooNE operations, several excess noise sources in the TPC were identified and mitigated. The residual equivalent noise charge (ENC) after noise filtering varies with wire length and is found to be below 400 electrons for the longest wires (4.7 m). The response is consistent with the cold electronics design expectations and is found to be stable with time and uniform over the functioning channels. In conclusion, this noise level is significantly lower than previous experiments utilizing warm front-end electronics.« less

Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca2+ Signaling and Endolysosomal Trafficking

PubMed Central

Ruas, Margarida; Rietdorf, Katja; Arredouani, Abdelilah; Davis, Lianne C.; Lloyd-Evans, Emyr; Koegel, Heidi; Funnell, Timothy M.; Morgan, Anthony J.; Ward, John A.; Watanabe, Keiko; Cheng, Xiaotong; Churchill, Grant C.; Zhu, Michael X.; Platt, Frances M.; Wessel, Gary M.; Parrington, John; Galione, Antony

2010-01-01

Summary Intracellular Ca2+ signals constitute key elements in signal transduction. Of the three major Ca2+ mobilizing messengers described, the most potent, nicotinic acid adenine dinucleotide phosphate (NAADP) is the least well understood in terms of its molecular targets [1]. Recently, we showed that heterologous expression of two-pore channel (TPC) proteins enhances NAADP-induced Ca2+ release, whereas the NAADP response was abolished in pancreatic beta cells from Tpcn2 gene knockout mice [2]. However, whether TPCs constitute native NAADP receptors is unclear. Here we show that immunopurified endogenous TPC complexes possess the hallmark properties ascribed to NAADP receptors, including nanomolar ligand affinity [3–5]. Our study also reveals important functional differences between the three TPC isoforms. Thus, TPC1 and TPC2 both mediate NAADP-induced Ca2+ release, but the subsequent amplification of this trigger Ca2+ by IP3Rs is more tightly coupled for TPC2. In contrast, TPC3 expression suppressed NAADP-induced Ca2+ release. Finally, increased TPC expression has dramatic and contrasting effects on endolysosomal structures and dynamics, implicating a role for NAADP in the regulation of vesicular trafficking. We propose that NAADP regulates endolysosomal Ca2+ storage and release via TPCs and coordinates endoplasmic reticulum Ca2+ release in a role that impacts on Ca2+ signaling in health and disease [6]. PMID:20346675

Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking.

PubMed

Ruas, Margarida; Rietdorf, Katja; Arredouani, Abdelilah; Davis, Lianne C; Lloyd-Evans, Emyr; Koegel, Heidi; Funnell, Timothy M; Morgan, Anthony J; Ward, John A; Watanabe, Keiko; Cheng, Xiaotong; Churchill, Grant C; Zhu, Michael X; Platt, Frances M; Wessel, Gary M; Parrington, John; Galione, Antony

2010-04-27

Intracellular Ca(2+) signals constitute key elements in signal transduction. Of the three major Ca(2+) mobilizing messengers described, the most potent, nicotinic acid adenine dinucleotide phosphate (NAADP) is the least well understood in terms of its molecular targets [1]. Recently, we showed that heterologous expression of two-pore channel (TPC) proteins enhances NAADP-induced Ca(2+) release, whereas the NAADP response was abolished in pancreatic beta cells from Tpcn2 gene knockout mice [2]. However, whether TPCs constitute native NAADP receptors is unclear. Here we show that immunopurified endogenous TPC complexes possess the hallmark properties ascribed to NAADP receptors, including nanomolar ligand affinity [3-5]. Our study also reveals important functional differences between the three TPC isoforms. Thus, TPC1 and TPC2 both mediate NAADP-induced Ca(2+) release, but the subsequent amplification of this trigger Ca(2+) by IP(3)Rs is more tightly coupled for TPC2. In contrast, TPC3 expression suppressed NAADP-induced Ca(2+) release. Finally, increased TPC expression has dramatic and contrasting effects on endolysosomal structures and dynamics, implicating a role for NAADP in the regulation of vesicular trafficking. We propose that NAADP regulates endolysosomal Ca(2+) storage and release via TPCs and coordinates endoplasmic reticulum Ca(2+) release in a role that impacts on Ca(2+) signaling in health and disease [6]. Copyright © 2010 Elsevier Ltd. All rights reserved.

The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes.

PubMed

Castonguay, Jan; Orth, Joachim H C; Müller, Thomas; Sleman, Faten; Grimm, Christian; Wahl-Schott, Christian; Biel, Martin; Mallmann, Robert Theodor; Bildl, Wolfgang; Schulte, Uwe; Klugbauer, Norbert

2017-08-30

Two-pore channels (TPCs) are localized in endo-lysosomal compartments and assumed to play an important role for vesicular fusion and endosomal trafficking. Recently, it has been shown that both TPC1 and 2 were required for host cell entry and pathogenicity of Ebola viruses. Here, we investigate the cellular function of TPC1 using protein toxins as model substrates for distinct endosomal processing routes. Toxin uptake and activation through early endosomes but not processing through other compartments were reduced in TPC1 knockout cells. Detailed co-localization studies with subcellular markers confirmed predominant localization of TPC1 to early and recycling endosomes. Proteomic analysis of native TPC1 channels finally identified direct interaction with a distinct set of syntaxins involved in fusion of intracellular vesicles. Together, our results demonstrate a general role of TPC1 for uptake and processing of proteins in early and recycling endosomes, likely by providing high local Ca 2+ concentrations required for SNARE-mediated vesicle fusion.

GEM detector performance with innovative micro-TPC readout in high magnetic field

NASA Astrophysics Data System (ADS)

Garzia, I.; Alexeev, M.; Amoroso, A.; Baldini Ferroli, R.; Bertani, M.; Bettoni, D.; Bianchi, F.; Calcaterra, A.; Canale, N.; Capodiferro, M.; Cassariti, V.; Cerioni, S.; Chai, J. Y.; Chiozzi, S.; Cibinetto, G.; Cossio, F.; Cotta Ramusino, A.; De Mori, F.; Destefanis, M.; Dong, J.; Evangelisti, F.; Evangelisti, F.; Farinelli, R.; Fava, L.; Felici, G.; Fioravanti, E.; Gatta, M.; Greco, M.; Lavezzi, L.; Leng, C. Y.; Li, H.; Maggiora, M.; Malaguti, R.; Marcello, S.; Melchiorri, M.; Mezzadri, G.; Mignone, M.; Morello, G.; Pacetti, S.; Patteri, P.; Pellegrino, J.; Pelosi, A.; Rivetti, A.; Rolo, M. D.; Savrié, M.; Scodeggio, M.; Soldani, E.; Sosio, S.; Spataro, S.; Tskhadadze, E.; Verma, S.; Wheadon, R.; Yan, L.

2018-01-01

Gas detector development is one of the pillars of the research in fundamental physics. Since several years, a new concept of detectors, called Micro Pattern Gas Detector (MPGD), allowed to overcome several problems related to other types of commonly used detectors, like drift chamber and micro strips detectors, reducing the rate of discharges and providing better radiation tolerance. Among the most used MPGDs are the Gas Electron Multipliers (GEMs). Invented by Sauli in 1997, nowadays GEMs have become an important reality for particle detectors in high energy physics. Commonly deployed as fast timing detectors and triggers, their fast response, high rate capability and high radiation hardness make them also suitable as tracking detectors. The readout scheme is one of the most important features in tracking technology. Analog readout based on the calculation of the center of gravity technique allows to overcome the limit imposed by digital pads, whose spatial resolution is limited by the pitch dimensions. However, the presence of high external magnetic fields can distort the electronic cloud and affect the performance. The development of the micro-TPC reconstruction method brings GEM detectors into a new prospective, improving significantly the spatial resolutionin presence of high magnetic fields. This innovative technique allows to reconstruct the 3-dimensional particle position, as Time Projection Chamber, but within a drift gap of a few millimeters. In these report, the charge centroid and micro-TPC methods are described in details. We discuss the results of several test beams performed with planar chambers in magnetic field. These results are one of the first developments of micro-TPC technique for GEM detectors, which allows to reach unprecedented performance in a high magnetic field of 1 T.

Enhanced trigger for the NIFFTE fissionTPC in presence of high-rate alpha backgrounds

NASA Astrophysics Data System (ADS)

Bundgaard, Jeremy; Niffte Collaboration

2015-10-01

Nuclear physics and nuclear energy communities call for new, high precision measurements to improve existing fission models and design next generation reactors. The Neutron Induced Fission Fragment Tracking experiment (NIFFTE) has developed the fission Time Projection Chamber (fissionTPC) to measure neutron induced fission with unrivaled precision. The fissionTPC is annually deployed to the Weapons Neutron Research facility at Los Alamos Neutron Science Center where it operates with a neutron beam passing axially through the drift volume, irradiating heavy actinide targets to induce fission. The fissionTPC was developed at the Lawrence Livermore National Laboratory's TPC lab, where it measures spontaneous fission from radioactive sources to characterize detector response, improve performance, and evolve the design. To measure 244Cm, we've developed a fission trigger to reduce the data rate from alpha tracks while maintaining a high fission detection efficiency. In beam, alphas from 239Pu are a large background when detecting fission fragments; implementing the fission trigger will greatly reduce this background. The implementation of the cathode fission trigger in the fissionTPC will be presented along with a detailed study of its efficiency.

Project Icarus: Stakeholder Scenarios for an Interstellar Exploration Program

NASA Astrophysics Data System (ADS)

Hein, A. M.; Tziolas, A. C.; Osborne, R.

The Project Icarus Study Group's objective is to design a mainly fusion-propelled interstellar probe. The starting point are the results of the Daedalus study, which was conducted by the British Interplanetary Society during the 1970's. As the Daedalus study already indicated, interstellar probes will be the result of a large scale, decade-long development program. To sustain a program over such long periods, the commitment of key stakeholders is vital. Although previous publications identified political and societal preconditions to an interstellar exploration program, there is a lack of more specific scientific and political stakeholder scenarios. This paper develops stakeholder scenarios which allow for a more detailed sustainability assessment of future programs. For this purpose, key stakeholder groups and their needs are identified and scientific and political scenarios derived. Political scenarios are based on patterns of past space programs but unprecedented scenarios are considered as well. Although it is very difficult to sustain an interstellar exploration program, there are scenarios in which this seems to be possible, e.g. the discovery of life within the solar system and on an exoplanet, a global technology development program, and dual-use of technologies for defence and security purposes. This is a submission of the Project Icarus Study Group.

Verification of the Icarus Material Response Tool

NASA Technical Reports Server (NTRS)

Schroeder, Olivia; Palmer, Grant; Stern, Eric; Schulz, Joseph; Muppidi, Suman; Martin, Alexandre

2017-01-01

Due to the complex physics encountered during reentry, material response solvers are used for two main purposes: improve the understanding of the physical phenomena; and design and size thermal protection systems (TPS). Icarus, is a three dimensional, unstructured material response tool that is intended to be used for design while maintaining the flexibility to easily implement physical models as needed. Because TPS selection and sizing is critical, it is of the utmost importance that the design tools be extensively verified and validated before their use. Verification tests aim at insuring that the numerical schemes and equations are implemented correctly by comparison to analytical solutions and grid convergence tests.

Sealed operation, and circulation and purification of gas in the HARPO TPC

NASA Astrophysics Data System (ADS)

Frotin, M.; Gros, P.; Attié, D.; Bernard, D.; Dauvois, V.; Delbart, A.; Durand, D.; Geerebaert, Y.; Legand, S.; Magnier, P.; Poilleux, P.; Semeniouk, I.

2018-02-01

HARPO is a time projection chamber (TPC) demonstrator of a gamma-ray telescope and polarimeter in the MeV-GeV range, for a future space mission. We present the evolution of the TPC performance over a five month sealed-mode operation, by the analysis of cosmic-ray data, followed by the fast and complete recovery of the initial gas properties using a lightweight gas circulation and purification system.

Metal-core pad-plane development for ACTAR TPC

NASA Astrophysics Data System (ADS)

Giovinazzo, J.; Pibernat, J.; Goigoux, T.; de Oliveira, R.; Grinyer, G. F.; Huss, C.; Mauss, B.; Pancin, J.; Pedroza, J. L.; Rebii, A.; Roger, T.; Rosier, P.; Saillant, F.; Wittwer, G.

2018-06-01

With the recent development of active targets and time projection chambers (ACTAR TPC) as detectors for fundamental nuclear physics experiments, the need arose for charge collection planes with a high density of readout channels. In order to fulfill the mechanical constraints for the ACTAR TPC device, we designed a pad-plane based on a metal-core circuit with an conceptually simple design and routing for signal readout, named FAKIR (in reference to a fakir bed of nails). A test circuit has been equipped with a micro mesh gaseous structure (micromegas) for signal amplification and a dedicated readout electronics. Test measurements have been performed with an 55Fe X-ray source giving an intrinsic energy resolution (FWHM) of 22 ± 1% at 5 . 9 keV, and with a 3-alpha source for which a resolution of about 130 ± 20 keV at 4 . 8 MeV has been estimated. The pad-plane has been mounted into a reduced size demonstrator version of the ACTAR TPC detector, in order to illustrate charged particle track reconstruction. The tests preformed with the X-ray and the 3-alpha sources shows that results obtained from pads signals are comparable to the intrinsic result from the micro-mesh signal. In addition, a simple alpha particle tracks analysis is performed to demonstrate that the pad plane allows a precise reconstruction of the direction and length of the trajectories.

Icarus Institute for Interstellar Sciences (IIS)

NASA Astrophysics Data System (ADS)

Cress, B.

2012-09-01

In this paper, a vision for a proposed interstellar research center, to be developed in the United States, will be presented. The major focus will be on an innovative approach to the planning and achieving a new sustainable world class facility devoted to the technologies and various science missions of multi-disciplined teams reaching for the stars. The project will provide the personnel, feature sets, facilities and equipment needed to initiate and support an aggressive program of advanced interstellar vehicle and propulsion design and implementation. Also shared will be personal insights and economic considerations gained during prior planning for a private research institute in Nevada, home to more than 300 international scientists. The views expressed in this discussion paper are the personal views of the author and not necessarily representing the entire Icarus team.

Performance Evaluation of the COBRA GEM for the Application of the TPC

NASA Astrophysics Data System (ADS)

Terasaki, Kohei; Hamagaki, Hideki; Gunji, Taku; Yamaguchi, Yorito

2014-09-01

Suppression of the back-drifting ions from avalanche region to drift space (IBF: Ion Backflow) is the key for a Time Projection Chamber (TPC) since IBF easily distorts the drift field. To suppress IBF, Gating Grid system is widely used for the TPC but this limits the data taking rate. Gas Electron Multiplier (GEM) has advantages in the reduction of IBF and high rate capability. By adopting GEM, it is possible to run a TPC continuously under high rate and high multiplicity conditions. Motivated by the study of IBF reduction for RICH with Thick COBRA, which has been developed by F. A. Amero et al., we developed COBRA GEMs for the application of a TPC. With a stack configuration, IBF reaches about 0.1 ~ 0.5%, which is ×5--10 better IBF than the standard GEMs. However, the measured energy resolution with COBRA is 20% (σ) and this is much worse than the resolution with standard GEMs. Measurement of long-time stability of gain indicates that gain of COBRA varies significantly due to charging up effect. Simulation studies based on Garfield++ are performed for understanding quantitatively the reasons of worse energy resolution and instability of gain. In this presentation, we will report the simulation studies together with the measured performance of the COBRA GEM.

Absence of Intracellular Ion Channels TPC1 and TPC2 Leads to Mature-Onset Obesity in Male Mice, Due to Impaired Lipid Availability for Thermogenesis in Brown Adipose Tissue

PubMed Central

Lear, Pamela V.; González-Touceda, David; Porteiro Couto, Begoña; Viaño, Patricia; Guymer, Vanessa; Remzova, Elena; Tunn, Ruth; Chalasani, Annapurna; García-Caballero, Tomás; Hargreaves, Iain P.; Tynan, Patricia W.; Christian, Helen C.; Nogueiras, Rubén

2015-01-01

Intracellular calcium-permeable channels have been implicated in thermogenic function of murine brown and brite/beige adipocytes, respectively transient receptor potential melastin-8 and transient receptor potential vanilloid-4. Because the endo-lysosomal two-pore channels (TPCs) have also been ascribed with metabolic functionality, we studied the effect of simultaneously knocking out TPC1 and TPC2 on body composition and energy balance in male mice fed a chow diet. Compared with wild-type mice, TPC1 and TPC2 double knockout (Tpcn1/2−/−) animals had a higher respiratory quotient and became obese between 6 and 9 months of age. Although food intake was unaltered, interscapular brown adipose tissue (BAT) maximal temperature and lean-mass adjusted oxygen consumption were lower in Tpcn1/2−/− than in wild type mice. Phosphorylated hormone-sensitive lipase expression, lipid density and expression of β-adrenergic receptors were also lower in Tpcn1/2−/− BAT, whereas mitochondrial respiratory chain function and uncoupling protein-1 expression remained intact. We conclude that Tpcn1/2−/− mice show mature-onset obesity due to reduced lipid availability and use, and a defect in β-adrenergic receptor signaling, leading to impaired thermogenic activity, in BAT. PMID:25545384

26 CFR 1.6041-1T - Return of information as to payments of $600 or more (temporary).

Code of Federal Regulations, 2014 CFR

2014-04-01

... 26 Internal Revenue 13 2014-04-01 2014-04-01 false Return of information as to payments of $600 or more (temporary). 1.6041-1T Section 1.6041-1T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF.... The applicability of this section expires on February 28, 2017. [T.D. 9658, 79 FR 12793, Mar. 6, 2014] ...

Precise Nuclear Data Measurements Possible with the NIFFTE fissionTPC for Advanced Reactor Designs

NASA Astrophysics Data System (ADS)

Towell, Rusty; Niffte Collaboration

2015-10-01

The Neutron Induced Fission Fragment Tracking Experiment (NIFFTE) Collaboration has applied the proven technology of Time Projection Chambers (TPC) to the task of precisely measuring fission cross sections. With the NIFFTE fission TPC, precise measurements have been made during the last year at the Los Alamos Neutron Science Center from both U-235 and Pu-239 targets. The exquisite tracking capabilities of this device allow the full reconstruction of charged particles produced by neutron beam induced fissions from a thin central target. The wealth of information gained from this approach will allow systematics to be controlled at the level of 1%. The fissionTPC performance will be presented. These results are critical to the development of advanced uranium-fueled reactors. However, there are clear advantages to developing thorium-fueled reactors such as Liquid Fluoride Thorium Reactors over uranium-fueled reactors. These advantages include improved reactor safety, minimizing radioactive waste, improved reactor efficiency, and enhanced proliferation resistance. The potential for using the fissionTPC to measure needed cross sections important to the development of thorium-fueled reactors will also be discussed.

Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition

PubMed Central

Hockey, Leanne N.; Kilpatrick, Bethan S.; Eden, Emily R.; Lin-Moshier, Yaping; Brailoiu, G. Cristina; Brailoiu, Eugen; Futter, Clare E.; Schapira, Anthony H.; Marchant, Jonathan S.; Patel, Sandip

2015-01-01

ABSTRACT Two-pore channels (TPCs) are endolysosomal ion channels implicated in Ca2+ signalling from acidic organelles. The relevance of these ubiquitous proteins for human disease, however, is unclear. Here, we report that lysosomes are enlarged and aggregated in fibroblasts from Parkinson disease patients with the common G2019S mutation in LRRK2. Defects were corrected by molecular silencing of TPC2, pharmacological inhibition of TPC regulators [Rab7, NAADP and PtdIns(3,5)P2] and buffering local Ca2+ increases. NAADP-evoked Ca2+ signals were exaggerated in diseased cells. TPC2 is thus a potential drug target within a pathogenic LRRK2 cascade that disrupts Ca2+-dependent trafficking in Parkinson disease. PMID:25416817

TPC2 mediates new mechanisms of platelet dense granule membrane dynamics through regulation of Ca2+ release

PubMed Central

Ambrosio, Andrea L.; Boyle, Judith A.; Di Pietro, Santiago M.

2015-01-01

Platelet dense granules (PDGs) are acidic calcium stores essential for normal hemostasis. They develop from late endosomal compartments upon receiving PDG-specific proteins through vesicular trafficking, but their maturation process is not well understood. Here we show that two-pore channel 2 (TPC2) is a component of the PDG membrane that regulates PDG luminal pH and the pool of releasable Ca2+. Using a genetically encoded Ca2+ biosensor and a pore mutant TPC2, we establish the function of TPC2 in Ca2+ release from PDGs and the formation of perigranular Ca2+ nanodomains. For the first time, Ca2+ spikes around PDGs—or any organelle of the endolysosome family—are visualized in real time and revealed to precisely mark organelle “kiss-and-run” events. Further, the presence of membranous tubules transiently connecting PDGs is revealed and shown to be dramatically enhanced by TPC2 in a mechanism that requires ion flux through TPC2. “Kiss-and-run” events and tubule connections mediate transfer of membrane proteins and luminal content between PDGs. The results show that PDGs use previously unknown mechanisms of membrane dynamics and content exchange that are regulated by TPC2. PMID:26202466

DarkSide-50: A WIMP Search with a Two-phase Argon TPC

NASA Astrophysics Data System (ADS)

Meyers, P. D.; Agnes, P.; Alton, D.; Arisaka, K.; Back, H. O.; Baldin, B.; Biery, K.; Bonfini, G.; Bossa, M.; Brigatti, A.; Brodsky, J.; Budano, F.; Cadonati, L.; Calaprice, F.; Canci, N.; Candela, A.; Cao, H.; Cariello, M.; Cavalcante, P.; Chavarria, A.; Chepurnov, A.; Cocco, A. G.; Crippa, L.; DAngelo, D.; D'Incecco, M.; Davini, S.; De Deo, M.; Derbin, A.; Di Eusanio, F.; Di Pietro, G.; Edkins, E.; Empl, A.; Fan, A.; Fiorillo, G.; Fomenko, K.; Forster, G.; Franco, D.; Gabriele, F.; Galbiati, C.; Goretti, A.; Grandi, L.; Gromov, M.; Guan, M.; Guardincerri, Y.; Hackett, B.; Herner, K.; Humble, P.; Hungerford, E. V.; Ianni, Al.; Ianni, An.; Joliet, C.; Keeter, K.; Kendziora, C.; Kidner, S.; Kobychev, V.; Koh, G.; Korablev, D.; Korga, G.; Kurlej, A.; Li, P.; Loer, B.; Lombardi, P.; Love, C.; Ludhova, L.; Luitz, S.; Ma, Y.; Machulin, I.; Mandarano, A.; Mari, S.; Maricic, J.; Martoff, C. J.; Meregaglia, A.; Meroni, E.; Meyers, P. D.; Milincic, R.; Montanari, D.; Montuschi, M.; Monzani, M. E.; Mosteiro, P.; Mount, B.; Muratova, V.; Musico, P.; Nelson, A.; Okounkova, M.; Orsini, M.; Ortica, F.; Pagani, L.; Pallavicini, M.; Pantic, E.; Papp, L.; Parmeggiano, S.; Parsells, R.; Pelczar, K.; Pelliccia, N.; Perasso, S.; Perfetto, F.; Pocar, A.; Pordes, S.; Qian, H.; Randle, K.; Ranucci, G.; Razeto, A.; Reinhold, B.; Romani, A.; Rossi, B.; Rossi, N.; Rountree, S. D.; Sablone, D.; Saggese, P.; Saldanha, R.; Sands, W.; Segreto, E.; Semenov, D.; Shields, E.; Skorokhvatov, M.; Smirnov, O.; Sotnikov, A.; Suvarov, Y.; Tartaglia, R.; Tatarowicz, J.; Testera, G.; Tonazzo, A.; Unzhakov, E.; Vogelaar, R. B.; Wada, M.; Wang, H.; Wang, Y.; Watson, A.; Westerdale, R.; Wojcik, M.; Wright, A.; Xu, J.; Yang, C.; Yoo, J.; Zavatarelli, S.; Zuzel, G.

DarkSide-50 is a two phase argon TPC for direct dark matter detection which is installed at the Gran Sasso underground laboratory, Italy. DarkSide-50 has a 50-kg active volume and will make use of underground argon low in 39Ar. The TPC is installed inside an active neutron veto made with boron-loaded high radiopurity liquid scintillator. The neutron veto is installed inside a 1000 m3 water Cherenkov muon veto. The DarkSide-50 TPC and cryostat are assembled in two radon-free clean rooms to reduce radioactive contaminants. The overall design aims for a background free exposure after selection cuts are applied. The expected sensitivity for WIMP-nucleon cross section is of the order of 10-45 cm2 for WIMP masses around 100 GeV/c2. The commissioning and performance of the detector are described. Details of the low-radioactivity underground argon and other unique features of the projects are reported.

Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition.

PubMed

Hockey, Leanne N; Kilpatrick, Bethan S; Eden, Emily R; Lin-Moshier, Yaping; Brailoiu, G Cristina; Brailoiu, Eugen; Futter, Clare E; Schapira, Anthony H; Marchant, Jonathan S; Patel, Sandip

2015-01-15

Two-pore channels (TPCs) are endolysosomal ion channels implicated in Ca(2+) signalling from acidic organelles. The relevance of these ubiquitous proteins for human disease, however, is unclear. Here, we report that lysosomes are enlarged and aggregated in fibroblasts from Parkinson disease patients with the common G2019S mutation in LRRK2. Defects were corrected by molecular silencing of TPC2, pharmacological inhibition of TPC regulators [Rab7, NAADP and PtdIns(3,5)P2] and buffering local Ca(2+) increases. NAADP-evoked Ca(2+) signals were exaggerated in diseased cells. TPC2 is thus a potential drug target within a pathogenic LRRK2 cascade that disrupts Ca(2+)-dependent trafficking in Parkinson disease. © 2015. Published by The Company of Biologists Ltd.

3D reconstruction of nuclear reactions using GEM TPC with planar readout

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bihałowicz, Jan Stefan

2015-02-24

The research program of the Extreme Light Infrastructure – Nuclear Physics (ELI-NP) laboratory under construction in Magurele, Romania facilities the need of developing a gaseous active-target detector providing 3D reconstruction of charged products of nuclear reactions induced by gamma beam. The monoenergetic, high-energy (E{sub γ} > 19 MeV) gamma beam of intensity 10{sup 13}γ/s allows studying nuclear reactions in astrophysics. A Time Projection Chamber with crossed strip readout (eTPC) is proposed as one of the imaging detectors. The special feature of the readout electrode structure is a 2D reconstruction based on the information read out simultaneously from three arrays ofmore » strips that form virtual pixels. It is expected to reach similar spatial resolution as for pixel readout at largely reduced cost of electronics. The paper presents the current progress and first results of the small scale prototype TPC which is a one of implementation steps towards eTPC detector proposed in the Technical Design Report of Charged Particles Detection at ELI-NP.« less

NEXT, a HPXe TPC for neutrinoless double beta decay searches

NASA Astrophysics Data System (ADS)

Gómez-Cadenas, J. J.; Martín-Albo, J.

2008-11-01

The next-generation experiments for neutrinoless double beta decay searches are a major challenge, since the detectors have to fulfill conflicting requirements: they have to be very massive and scalable; very sensitive to the signature of the ββ processes, and simultaneously impose extremely stringent limits on the copious backgrounds. A high-pressure gaseous Xenon TPC may be the ideal detector for this purpose: the isotope 136Xe is almost 9% of natural Xenon and enrichment by centrifugation is a relatively easy technology as demonstrated by the EXO collaboration; the detector can be extrapolated to large masses; energy resolution in gas is expected to be at the level of 1% FWHM at Qββ this fact, combined with the very long life of the ββ2ν mode accounts for negligible backgrounds of intrinsic origin up to masses of the order of 1 ton. The detector is fully active and the gas can be continuously re-circulated and purified, which, together with the existence of a kinematical signature gives an extra handle against backgrounds. NEXT (Neutrino Experiment with a Xenon TPC) is an on-going project that aims to build a 100 kg HPXe TPC at a pressure of ~10 bar. The experiment has already been aproved by the scientific committee of the Canfranc Underground Laboratory (LSC), in Spain, for the initial R&D phase. The NEXT Collaboration has defined an ambitious roadmap for the next five years: an initial phase of R&D during 2 years will be used to decide the technology (MicroMegas, GEMs. APDs. PMTs, etc.); in 3 years a first prototype (NEXT-10) will be constructed; followed by NEXT-100 in 5 years. A special grant (Consolider-Ingenio 2010) from the Ministry of Science of Spain will fund the experiment during this period. The Collaboration is composed by the leading Spanish groups in experimental neutrino and underground physics. The general ideas behind neutrinoless double beta decay searches with a HPXe TPC are discussed in this note.

Structure of Voltage-gated Two-pore Channel TPC1 from Arabidopsis thaliana

PubMed Central

Guo, Jiangtao; Zeng, Weizhong; Chen, Qingfeng; Lee, Changkeun; Chen, Liping; Yang, Yi; Cang, Chunlei; Ren, Dejian; Jiang, Youxing

2015-01-01

Two-pore channels (TPCs) contain two copies of a Shaker-like six-transmembrane (6-TM) domain in each subunit and are ubiquitously expressed in both animals and plants as organellar cation channels. Here, we present the first crystal structure of a vacuolar two-pore channel from Arabidopsis thaliana, AtTPC1, which functions as a homodimer. AtTPC1 activation requires both voltage and cytosolic Ca2+. Ca2+ binding to the cytosolic EF-hand domain triggers conformational changes coupled to the pair of pore-lining inner helices (IS6 helices) from the first 6-TM domains, whereas membrane potential only activates the second voltage-sensing domain (VSD2) whose conformational changes are coupled to the pair of inner helices (IIS6 helices) from the second 6-TM domains. Luminal Ca2+ or Ba2+ can modulate voltage activation by stabilizing VSD2 in the resting state and shifts voltage activation towards more positive potentials. Our Ba2+ bound AtTPC1 structure reveals a voltage sensor in the resting state, providing hitherto unseen structural insight into the general voltage-gating mechanism among voltage-gated channels. PMID:26689363

Effect of Interferon-γ on the Basal and the TNFα-Stimulated Secretion of CXCL8 in Thyroid Cancer Cell Lines Bearing Either the RET/PTC Rearrangement Or the BRAF V600e Mutation

PubMed Central

Rotondi, Mario; Coperchini, Francesca; Awwad, Oriana; Di Buduo, Christian A.; Abbonante, Vittorio; Magri, Flavia; Balduini, Alessandra

2016-01-01

CXCL8 displays several tumor-promoting effects. Targeting and/or lowering CXCL8 concentrations within the tumor microenvironment would produce a therapeutic benefit. Aim of this study was to test the effect of IFNγ on the basal and TNFα-stimulated secretion of CXCL8 in TCP-1 and BCPAP thyroid cancer cell lines (harboring RET/PTC rearrangement and BRAF V600e mutation, resp.). Cells were incubated with IFNγ (1, 10, 100, and 1000 U/mL) alone or in combination with TNF-α (10 ng/mL) for 24 hours. CXCL8 and CXCL10 concentrations were measured in the cell supernatants. IFNγ inhibited in a dose-dependent and significant manner both the basal (ANOVA F: 22.759; p < 0.00001) and the TNFα-stimulated (ANOVA F: 15.309; p < 0.00001) CXCL8 secretions in BCPAP but not in TPC-1 cells (NS). On the other hand, IFNγ and IFNγ + TNF-α induced a significant secretion of CXCL10 in both BCPAP (p < 0.05) and TPC-1 (p < 0.05) cells. Transwell migration assay showed that (i) CXCL8 increased cell migration in both TPC-1 and BCPAP cells; (ii) IFNγ significantly reduced the migration only of BCPAP cells; and (iii) CXCL8 reverted the effect of IFNγ. These results constitute the first demonstration that IFNγ inhibits CXCL8 secretion and in turn the migration of a BRAF V600e mutated thyroid cell line. PMID:27555670

Effect of Interferon-γ on the Basal and the TNFα-Stimulated Secretion of CXCL8 in Thyroid Cancer Cell Lines Bearing Either the RET/PTC Rearrangement Or the BRAF V600e Mutation.

PubMed

Rotondi, Mario; Coperchini, Francesca; Awwad, Oriana; Pignatti, Patrizia; Di Buduo, Christian A; Abbonante, Vittorio; Magri, Flavia; Balduini, Alessandra; Chiovato, Luca

2016-01-01

CXCL8 displays several tumor-promoting effects. Targeting and/or lowering CXCL8 concentrations within the tumor microenvironment would produce a therapeutic benefit. Aim of this study was to test the effect of IFNγ on the basal and TNFα-stimulated secretion of CXCL8 in TCP-1 and BCPAP thyroid cancer cell lines (harboring RET/PTC rearrangement and BRAF V600e mutation, resp.). Cells were incubated with IFNγ (1, 10, 100, and 1000 U/mL) alone or in combination with TNF-α (10 ng/mL) for 24 hours. CXCL8 and CXCL10 concentrations were measured in the cell supernatants. IFNγ inhibited in a dose-dependent and significant manner both the basal (ANOVA F: 22.759; p < 0.00001) and the TNFα-stimulated (ANOVA F: 15.309; p < 0.00001) CXCL8 secretions in BCPAP but not in TPC-1 cells (NS). On the other hand, IFNγ and IFNγ + TNF-α induced a significant secretion of CXCL10 in both BCPAP (p < 0.05) and TPC-1 (p < 0.05) cells. Transwell migration assay showed that (i) CXCL8 increased cell migration in both TPC-1 and BCPAP cells; (ii) IFNγ significantly reduced the migration only of BCPAP cells; and (iii) CXCL8 reverted the effect of IFNγ. These results constitute the first demonstration that IFNγ inhibits CXCL8 secretion and in turn the migration of a BRAF V600e mutated thyroid cell line.

Adaptive molecular evolution of the two-pore channel 1 gene TPC1 in the karst-adapted genus Primulina (Gesneriaceae)

PubMed Central

Tao, Junjie; Feng, Chao; Ai, Bin; Kang, Ming

2016-01-01

Background and Aims Limestone karst areas possess high floral diversity and endemism. The genus Primulina, which contributes to the unique calcicole flora, has high species richness and exhibit specific soil-based habitat associations that are mainly distributed on calcareous karst soils. The adaptive molecular evolutionary mechanism of the genus to karst calcium-rich environments is still not well understood. The Ca2+-permeable channel TPC1 was used in this study to test whether its gene is involved in the local adaptation of Primulina to karst high-calcium soil environments. Methods Specific amplification and sequencing primers were designed and used to amplify the full-length coding sequences of TPC1 from cDNA of 76 Primulina species. The sequence alignment without recombination and the corresponding reconstructed phylogeny tree were used in molecular evolutionary analyses at the nucleic acid level and amino acid level, respectively. Finally, the identified sites under positive selection were labelled on the predicted secondary structure of TPC1. Key Results Seventy-six full-length coding sequences of Primulina TPC1 were obtained. The length of the sequences varied between 2220 and 2286 bp and the insertion/deletion was located at the 5′ end of the sequences. No signal of substitution saturation was detected in the sequences, while significant recombination breakpoints were detected. The molecular evolutionary analyses showed that TPC1 was dominated by purifying selection and the selective pressures were not significantly different among species lineages. However, significant signals of positive selection were detected at both TPC1 codon level and amino acid level, and five sites under positive selective pressure were identified by at least three different methods. Conclusions The Ca2+-permeable channel TPC1 may be involved in the local adaptation of Primulina to karst Ca2+-rich environments. Different species lineages suffered similar selective pressure

The Icarus challenge - Predicting vulnerability to climate change using an algorithm-based species' trait approach

EPA Science Inventory

The Icarus challenge - Predicting vulnerability to climate change using an algorithm-based species’ trait approachHenry Lee II, Christina Folger, Deborah A. Reusser, Patrick Clinton, and Rene Graham1 U.S. EPA, Western Ecology Division, Newport, OR USA E-mail: lee.henry@ep...

The Icarus challenge - Predicting vulnerability to climate change using an algorithm-based species’ trait approach

EPA Science Inventory

Like Icarus, the world’s ecological resources are “flying too close” to the sun, and climate change will impact near-coastal species through temperature, sea-level rise, and ocean acidification and indirectly through changes in invasive species and land-use patt...

Effect of single- and two-cycle high hydrostatic pressure treatments on water properties, physicochemical and microbial qualities of minimally processed squids (todarodes pacificus).

PubMed

Zhang, Yifeng; Jiao, Shunshan; Lian, Zixuan; Deng, Yun; Zhao, Yanyun

2015-05-01

This study investigated the effect of single- and two-cycle high hydrostatic pressure (HHP) treatments on water properties, physicochemical, and microbial qualities of squids (Todarodes pacificus) during 4 °C storage for up to 10 d. Single-cycle treatments were applied at 200, 400, or 600 MPa for 20 min (S-200, S-400, and S-600), and two-cycle treatments consisted of two 10 min cycles at 200, 400, or 600 MPa, respectively (T-200, T-400, and T-600). HHP-treated samples had higher (P < 0.05) content of P2b (immobilized water) and P21 (myofibril water), but lower P22 (free water) than those of control. The single- and two-cycle HHP treatments at the same pressure level caused no significant difference in water state of squids. The two-cycle HHP treatment was more effective in controlling total volatile basic nitrogen, pH, and total plate counts (TPC) of squids during storage, in which TPC of S-600 and T-600 was 2.9 and 1.8 log CFU/g at 10 d, respectively, compared with 7.5 log CFU/g in control. HHP treatments delayed browning discoloration of the squids during storage, and the higher pressure level and two-cycle HHP were more effective. Water properties highly corresponded with color and texture indices of squids. This study demonstrated that the two-cycle HHP treatment was more effective in controlling microbial growth and quality deterioration while having similar impact on the physicochemical and water properties of squids in comparison with the single-cycle treatment, thus more desirable for extending shelf-life of fresh squids. © 2015 Institute of Food Technologists®

The XENONnT Dark Matter Experiment

NASA Astrophysics Data System (ADS)

Aprile, Elena; Xenon Collaboration

2017-01-01

With XENON1T ready to search for dark matter with the highest sensivity of any experiment to-date the XENON collaboration started to secure funding and resources to upgrade the detector by the end of 2018- phase which we refer to as XENONnT. The XENONnT experiment will utilize the already-built-and-tested XENON1T infrastructures, such as the cryogenic system, Kr distillation system and Xe storage and recovery system, with the main upgrade of the time projection chamber (TPC). The upgraded XENONnT detector will be filled with 7.5-ton ultra-pure liquid xenon, tripling the active liquid xenon target mass of XENON1T. About 500 low-radioactive three-inch R11410 PMTs will be used. Background from internal sources such as radon will be reduced. It will enable another order of magnitude improvement in dark matter search sensitivity compared to that of XENON1T, or accumulate statistics if a positive dark matter signal is observed by XENON1T. The detailed TPC upgrade plan, the background control and reduction techniques, the predicted sensitivity reach will be presented.

Developing the Multimedia User Interface Component (MUSIC) for the Icarus Presentation System (IPS)

DTIC Science & Technology

1993-12-01

AD-A276 341 In-House Report December 1993 DEVELOPING THE MULTIMEDIA USER INTERFACE COMPONENT ( MUSIC ) FOR THE ICARUS PRESENTATION SYSTEM (IPS) Ingrid...DATEs COVERED 7 December 1993 Ina-House Jun - Aug 93 4 TWLE AM SL1sM1E & FUNDING NUMBERS DEVELOPING THE MULTIMEDIA USER INTERFACE COMPONENT ( MUSIC ) PE...the Multimedia User Interface Component ( MUSIC ). This report documents the initial research, design and implementation of a prototype of the MUSIC

The BRAF{sup T1799A} mutation confers sensitivity of thyroid cancer cells to the BRAF{sup V600E} inhibitor PLX4032 (RG7204)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xing, Joanna; Liu, Ruixin; Xing, Mingzhao

2011-01-28

Research highlights: {yields} Exciting therapeutic potential has been recently reported for the BRAF{sup V600E} inhibitor PLX4032 in melanoma. {yields} We tested the effects of PLX4032 on the growth of thyroid cancer cells which often harbor the BRAF{sup V600E} mutation. {yields} We observed a potent BRAF{sup V600E}-dependent inhibition of thyroid cancer cells by PLX4032. {yields} We thus demonstrated an important therapeutic potential of PLX4032 for thyroid cancer. -- Abstract: Aberrant signaling of the Ras-Raf-MEK-ERK (MAP kinase) pathway driven by the mutant kinase BRAF{sup V600E}, as a result of the BRAF{sup T1799A} mutation, plays a fundamental role in thyroid tumorigenesis. This studymore » investigated the therapeutic potential of a BRAF{sup V600E}-selective inhibitor, PLX4032 (RG7204), for thyroid cancer by examining its effects on the MAP kinase signaling and proliferation of 10 thyroid cancer cell lines with wild-type BRAF or BRAF{sup T1799A} mutation. We found that PLX4032 could effectively inhibit the MAP kinase signaling, as reflected by the suppression of ERK phosphorylation, in cells harboring the BRAF{sup T1799A} mutation. PLX4032 also showed a potent and BRAF mutation-selective inhibition of cell proliferation in a concentration-dependent manner. PLX4032 displayed low IC{sub 50} values (0.115-1.156 {mu}M) in BRAF{sup V600E} mutant cells, in contrast with wild-type BRAF cells that showed resistance to the inhibitor with high IC{sub 50} values (56.674-1349.788 {mu}M). Interestingly, cells with Ras mutations were also sensitive to PLX4032, albeit moderately. Thus, this study has confirmed that the BRAF{sup T1799A} mutation confers cancer cells sensitivity to PLX4032 and demonstrated its specific potential as an effective and BRAF{sup T1799A} mutation-selective therapeutic agent for thyroid cancer.« less

Muon tomography of rock density using Micromegas-TPC telescope

NASA Astrophysics Data System (ADS)

Hivert, Fanny; Busto, José; Gaffet, Stéphane; Ernenwein, Jean-Pierre; Brunner, Jurgen; Salin, Pierre; Decitre, Jean-Baptiste; Lázaro Roche, Ignacio; Martin, Xavier

2014-05-01

The knowledge of the subsurface properties is essentially obtained by geophysical methods, e.g., seismic imaging, electric prospection or gravimetry. The current work is based on a recently developed method to investigate in situ the density of rocks using a measurement of the muon flux, whose attenuation depends on the quantity of matter the particles travel through and hence on the rock density and thickness. The present project (T2DM2) aims at performing underground muon flux measurements in order to characterize spatial and temporal rock massif density variations above the LSBB underground research facility in Rustrel (France). The muon flux will be measured with a new muon telescope device using Micromegas-Time Projection Chamber (TPC) detectors. The first step of the work presented covers the muon flux simulation based on the Gaisser model (Gaisser T., 1990), for the muon flux at the ground level, and on the MUSIC code (Kudryavtsev V. A., 2008) for the propagation of muons through the rock. The results show that the muon flux distortion caused by density variations is enough significant to be observed at 500 m depth for measurement times of about one month. This time-scale is compatible with the duration of the water transfer processes within the unsaturated Karst zone where LSBB is located. The work now focuses on the optimization of the detector layout along the LSBB galleries in order to achieve the best sensitivity.

Live event reconstruction in an optically read out GEM-based TPC

NASA Astrophysics Data System (ADS)

Brunbauer, F. M.; Galgóczi, G.; Gonzalez Diaz, D.; Oliveri, E.; Resnati, F.; Ropelewski, L.; Streli, C.; Thuiner, P.; van Stenis, M.

2018-04-01

Combining strong signal amplification made possible by Gaseous Electron Multipliers (GEMs) with the high spatial resolution provided by optical readout, highly performing radiation detectors can be realized. An optically read out GEM-based Time Projection Chamber (TPC) is presented. The device permits 3D track reconstruction by combining the 2D projections obtained with a CCD camera with timing information from a photomultiplier tube. Owing to the intuitive 2D representation of the tracks in the images and to automated control, data acquisition and event reconstruction algorithms, the optically read out TPC permits live display of reconstructed tracks in three dimensions. An Ar/CF4 (80/20%) gas mixture was used to maximize scintillation yield in the visible wavelength region matching the quantum efficiency of the camera. The device is integrated in a UHV-grade vessel allowing for precise control of the gas composition and purity. Long term studies in sealed mode operation revealed a minor decrease in the scintillation light intensity.

Development of the GEM-TPC X-ray Polarimeter with the Scalable Readout System

NASA Astrophysics Data System (ADS)

Kitaguchi, Takao; Hayato, Asami; Iwakiri, Wataru; Takeuchi, Yoko; Kubota, Megu; Nishida, Kazuki; Enoto, Teruaki; Tamagawa, Toru

2018-02-01

We have developed a gaseous Time Projection Chamber (TPC) containing a single-layered foil of a gas electron multiplier (GEM) to open up a new window on cosmic X-ray polarimetry in the 2-10 keV band. The micro-pattern TPC polarimeter in combination with the Scalable Readout System produced by the RD51 collaboration has been built as an engineering model to optimize detector parameters and improve polarimeter sensitivity. The polarimeter was characterized with unpolarized X-rays from an X-ray generator in a laboratory and polarized X-rays on the BL32B2 beamline at the SPring-8 synchrotron radiation facility. Preliminary results show that the polarimeter has a comparable modulation factor to a prototype of the flight one.

Disk Accretion in the 10 Myr Old T Tauri Stars TW Hydrae and Hen 3-600A.

PubMed

Muzerolle; Calvet; Briceño; Hartmann; Hillenbrand

2000-05-20

We have found that two members of the TW Hydrae association, TW Hydrae and Hen 3-600A, are still actively accreting, based on the ballistic infall signature of their broad Halpha emission profiles. We present the first quantitative analysis of accretion in these objects and conclude that the same accretion mechanisms which operate in the well-studied 1 Myr old T Tauri stars can and do occur in older (10 Myr) stars. We derive the first estimates of the disk mass accretion rate in TW Hya and Hen 3-600A, which are 1-2 orders of magnitude lower than the average rates in 1 Myr old objects. The decrease in accretion rates over 10 Myr, as well as the low fraction of TW Hya association objects still accreting, points to significant disk evolution, possibly linked to planet formation. Given the multiplicity of the Hen 3-600 system and the large UV excess of TW Hya, our results show that accretion disks can be surprisingly long lived in spite of the presence of companions and significant UV ionizing flux.

Performance of a liquid argon time projection chamber exposed to the CERN West Area Neutrino Facility neutrino beam

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arneodo, F.; Cavanna, F.; Mitri, I. De

2006-12-01

We present the results of the first exposure of a Liquid Argon TPC to a multi-GeV neutrino beam. The data have been collected with a 50 liters ICARUS-like chamber located between the CHORUS and NOMAD experiments at the CERN West Area Neutrino Facility (WANF). We discuss both the instrumental performance of the detector and its capability to identify and reconstruct low-multiplicity neutrino interactions.

SPiRIT-TPC with GET readout electronics for the study of density dependent symmetry energy of high dense matter with Heavy RI collisions

NASA Astrophysics Data System (ADS)

Isobe, Tadaaki; SPiRIT Collaboration

2014-09-01

The nuclear Equation of State (EoS) is a fundamental property of nuclear matter that describes the relationships between the parameters for a nuclear system, such as energy, density and temperature. An international collaboration, named SPiRIT, to study the nuclear EoS has been formed recently. One of the main devices of experimental setup is a Time Projection Chamber (TPC) which will be installed into the SAMURAI dipole magnet at RIKEN-RIBF. The TPC can measure charged pions, protons and light ions simultaneously in heavy RI collisions, and those will be used as probes to study the asymmetric dense nuclear matter. In addition to the status of the SPiRIT project, testing of SPiRIT-TPC with GET electronics will be presented in this talk. GET, general electronics for TPC, is a project for the development of novel electronics for TPC supported by NSF and ANR. This work is supported in part by the Japan Grant-in-Aide award and the US DOE grant DE-SC0004835 and JUSEIPEN.

TPC Proteins Are Phosphoinositide-activated Sodium-selective Ion Channels in Endosomes and Lysosomes

PubMed Central

Wang, Xiang; Zhang, Xiaoli; Dong, Xian-ping; Samie, Mohammad; Li, Xinran; Cheng, Xiping; Goschka, Andrew; Shen, Dongbiao; Zhou, Yandong; Harlow, Janice; Zhu, Michael X.; Clapham, David E.; Ren, Dejian; Xu, Haoxing

2012-01-01

Summary Mammalian Two-Pore Channels (TPC1, 2; TPCN1, TPCN2) encode ion channels in intracellular endosomes and lysosomes and were proposed to mediate endolysosomal calcium release triggered by the second messenger, nicotinic acid adenine dinucleotide phosphate (NAADP). By directly recording TPCs in endolysosomes from wild-type and TPC double knockout mice, here we show that, in contrast to previous conclusions, TPCs are in fact sodium-selective channels activated by PI(3,5)P2, and are not activated by NAADP. Moreover, the primary endolysosomal ion is Na+, not K+, as had been previously assumed. These findings suggest that the organellar membrane potential may undergo large regulatory changes, and may explain the specificity of PI(3,5)P2 in regulating the fusogenic potential of intracellular organelles. PMID:23063126

The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca2+ dynamics and insulin secretion

PubMed Central

Cane, Matthew C.; Parrington, John; Rorsman, Patrik; Galione, Antony; Rutter, Guy A.

2016-01-01

Ca2+ signals are central to the stimulation of insulin secretion from pancreatic β-cells by glucose and other agents, including glucagon-like peptide-1 (GLP-1). Whilst Ca2+ influx through voltage-gated Ca2+ channels on the plasma membrane is a key trigger for glucose-stimulated secretion, mobilisation of Ca2+ from acidic stores has been implicated in the control of more localised Ca2+ changes and membrane potential. Nicotinic acid adenine dinucleotide phosphate (NAADP), generated in β-cells in response to high glucose, is a potent mobiliser of these stores, and has been proposed to act through two pore channels (TPC1 and TPC2, murine gene names Tpcn1 and Tpcn2). Whilst the role of TPC1 in the control of Ca2+ mobilisation and insulin secretion was recently confirmed, conflicting data exist for TPC2. Here, we used the selective and efficient deleter strain, Ins1Cre to achieve β-cell selective deletion of the Tpcn2 gene in mice. βTpcn2 KO mice displayed normal intraperitoneal and oral glucose tolerance, and glucose-stimulated Ca2+ dynamics and insulin secretion from islets were similarly normal. GLP-1-induced Ca2+ increases involved an increase in oscillation frequency from 4.35 to 4.84 per minute (p = 0.04) at 8 mM glucose, and this increase was unaffected by the absence of Tpcn2. The current data thus indicate that TPC2 is not absolutely required for normal glucose- or incretin-stimulated insulin secretion from the β-cell. Our findings suggest that TPC1, whose expression tended to increase in Tpcn2 null islets, might be sufficient to support normal Ca2+ dynamics in response to stimulation by nutrients or incretins. PMID:26769314

The Icarus challenge - Predicting geographical and taxonomic patterns of vulnerability to climate change in near-coastal species

EPA Science Inventory

Like Icarus, the world's oceans are "flying too close" to the sun. Increases in temperature and sea level and reductions in pH will affect many, if not most, near-coastal species. The type and severity of the effects will vary both by species and regionally due to geogr...

TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms.

PubMed

Chao, Yu-Kai; Schludi, Verena; Chen, Cheng-Chang; Butz, Elisabeth; Nguyen, O N Phuong; Müller, Martin; Krüger, Jens; Kammerbauer, Claudia; Ben-Johny, Manu; Vollmar, Angelika M; Berking, Carola; Biel, Martin; Wahl-Schott, Christian A; Grimm, Christian

2017-10-10

Two-pore channels (TPCs) are endolysosomal cation channels. Two members exist in humans, TPC1 and TPC2. Functional roles associated with the ubiquitously expressed TPCs include VEGF-induced neoangiogenesis, LDL-cholesterol trafficking and degradation, physical endurance under fasting conditions, autophagy regulation, the acrosome reaction in sperm, cancer cell migration, and intracellular trafficking of pathogens such as Ebola virus or bacterial toxins (e.g., cholera toxin). In a genome-wide association study for variants associated with human pigmentation characteristics two coding variants of TPC2, rs35264875 (encoding M484L) and rs3829241 (encoding G734E), have been found to be associated with a shift from brown to blond hair color. In two recent follow-up studies a role for TPC2 in pigmentation has been further confirmed. However, these human polymorphic variants have not been functionally characterized until now. The development of endolysosomal patch-clamp techniques has made it possible to investigate directly ion channel activities and characteristics in isolated endolysosomal organelles. We applied this technique here to scrutinize channel characteristics of the polymorphic TPC2 variants in direct comparison with WT. We found that both polymorphisms lead to a gain of channel function by independent mechanisms. We next conducted a clinical study with more than 100 blond- and brown/black-haired individuals. We performed a genotype/phenotype analysis and subsequently isolated fibroblasts from WT and polymorphic variant carriers for endolysosomal patch-clamp experimentation to confirm key in vitro findings.

Gating of the two-pore cation channel AtTPC1 in the plant vacuole is based on a single voltage-sensing domain.

PubMed

Jaślan, D; Mueller, T D; Becker, D; Schultz, J; Cuin, T A; Marten, I; Dreyer, I; Schönknecht, G; Hedrich, R

2016-09-01

The two-pore cation channel TPC1 operates as a dimeric channel in animal and plant endomembranes. Each subunit consists of two homologous Shaker-like halves, with 12 transmembrane domains in total (S1-S6, S7-S12). In plants, TPC1 channels reside in the vacuolar membrane, and upon voltage stimulation, give rise to the well-known slow-activating SV currents. Here, we combined bioinformatics, structure modelling, site-directed mutagenesis, and in planta patch clamp studies to elucidate the molecular mechanisms of voltage-dependent channel gating in TPC1 in its native plant background. Structure-function analysis of the Arabidopsis TPC1 channel in planta confirmed that helix S10 operates as the major voltage-sensing site, with Glu450 and Glu478 identified as possible ion-pair partners for voltage-sensing Arg537. The contribution of helix S4 to voltage sensing was found to be negligible. Several conserved negative residues on the luminal site contribute to calcium binding, stabilizing the closed channel. During evolution of plant TPC1s from two separate Shaker-like domains, the voltage-sensing function in the N-terminal Shaker-unit (S1-S4) vanished. © 2016 German Botanical Society and The Royal Botanical Society of the Netherlands.

Optical readout of a two phase liquid argon TPC using CCD camera and THGEMs

NASA Astrophysics Data System (ADS)

Mavrokoridis, K.; Ball, F.; Carroll, J.; Lazos, M.; McCormick, K. J.; Smith, N. A.; Touramanis, C.; Walker, J.

2014-02-01

This paper presents a preliminary study into the use of CCDs to image secondary scintillation light generated by THick Gas Electron Multipliers (THGEMs) in a two phase LAr TPC. A Sony ICX285AL CCD chip was mounted above a double THGEM in the gas phase of a 40 litre two-phase LAr TPC with the majority of the camera electronics positioned externally via a feedthrough. An Am-241 source was mounted on a rotatable motion feedthrough allowing the positioning of the alpha source either inside or outside of the field cage. Developed for and incorporated into the TPC design was a novel high voltage feedthrough featuring LAr insulation. Furthermore, a range of webcams were tested for operation in cryogenics as an internal detector monitoring tool. Of the range of webcams tested the Microsoft HD-3000 (model no:1456) webcam was found to be superior in terms of noise and lowest operating temperature. In ambient temperature and atmospheric pressure 1 ppm pure argon gas, the THGEM gain was ≈ 1000 and using a 1 msec exposure the CCD captured single alpha tracks. Successful operation of the CCD camera in two-phase cryogenic mode was also achieved. Using a 10 sec exposure a photograph of secondary scintillation light induced by the Am-241 source in LAr has been captured for the first time.

Simulation of double beta decay in the ''SeXe'' TPC

NASA Astrophysics Data System (ADS)

Mauger, F.

2007-04-01

In 2004, the NEMO collaboration has started some preliminary studies for a next-generation double beta decay experiment: SuperNEMO. The possibility to use a large gaseous TPC has been investigated using simulation and extrapolation of former experiments. In this talk, I report on the reasons why such techniques have not been selected in 2004 and led the NEMO collaboration to reuse the techniques implemented within the NEMO3 detector.

Online Calibration of the TPC Drift Time in the ALICE High Level Trigger

NASA Astrophysics Data System (ADS)

Rohr, David; Krzewicki, Mikolaj; Zampolli, Chiara; Wiechula, Jens; Gorbunov, Sergey; Chauvin, Alex; Vorobyev, Ivan; Weber, Steffen; Schweda, Kai; Lindenstruth, Volker

2017-06-01

A Large Ion Collider Experiment (ALICE) is one of the four major experiments at the Large Hadron Collider (LHC) at CERN. The high level trigger (HLT) is a compute cluster, which reconstructs collisions as recorded by the ALICE detector in real-time. It employs a custom online data-transport framework to distribute data and workload among the compute nodes. ALICE employs subdetectors that are sensitive to environmental conditions such as pressure and temperature, e.g., the time projection chamber (TPC). A precise reconstruction of particle trajectories requires calibration of these detectors. Performing calibration in real time in the HLT improves the online reconstructions and renders certain offline calibration steps obsolete speeding up offline physics analysis. For LHC Run 3, starting in 2020 when data reduction will rely on reconstructed data, online calibration becomes a necessity. Reconstructed particle trajectories build the basis for the calibration making a fast online-tracking mandatory. The main detectors used for this purpose are the TPC and Inner Tracking System. Reconstructing the trajectories in the TPC is the most compute-intense step. We present several improvements to the ALICE HLT developed to facilitate online calibration. The main new development for online calibration is a wrapper that can run ALICE offline analysis and calibration tasks inside the HLT. In addition, we have added asynchronous processing capabilities to support long-running calibration tasks in the HLT framework, which runs event-synchronously otherwise. In order to improve the resiliency, an isolated process performs the asynchronous operations such that even a fatal error does not disturb data taking. We have complemented the original loop-free HLT chain with ZeroMQ data-transfer components. The ZeroMQ components facilitate a feedback loop that inserts the calibration result created at the end of the chain back into tracking components at the beginning of the chain, after a

Recent Results from ArgoNeuT and Status of MicroBooNE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Szelc, Andrzej

2015-07-10

Liquid Argon Time Projection Chamber (LArTPC) detectors hold the key to answering the outstanding questions about the role of neutrinos in the Standard Model of Particle physics and beyond. Their fine granularity combined with calorimetric capabilities allows for precision measurements that answering these questions will require. Here, we discuss the recent results from the ArgoNeuT experiment as well as the status and prospects for MicroBooNE, both a part of the US-based LArTPC neutrino program.

Status of the R&D activities for the upgrade of the ALICE TPC

NASA Astrophysics Data System (ADS)

Deisting, Alexander

2018-02-01

After the Long Shutdown 2 (LS2) the LHC will provide lead-lead collisions at interaction rates as high as 50 kHz. In order to cope with such conditions the ALICE Time Projection Chamber (TPC) needs to be upgraded. After the upgrade the TPC will run in a continuous mode, without any degradation of the momentum and dE/dx resolution compared to the performance of the present TPC. Since readout by multi-wire proportional chambers is no longer feasible with these requirements, new technologies have to be employed. In the new readout chambers the electron amplification is provided by a stack of four Gas ElectronMultiplier (GEM) foils. Here foils with a standard hole pitch of 140 μm as well as large pitch foils (280 μm) are used. Their high voltage settings and orientation have been optimised to provide an energy resolution of σE/E ≤ 12% at the photopeak of 55Fe. At the same settings the Ion BackFlow into the drift volume is less than 1% of the effective number of ions produced during gas amplification and the primary ionisations. This is necessary to prevent the accumulation of space charge, which eventually will distort the field in the drift volume. To ensure stable operation at the high loads during LHC run 3 the chambers have to be robust against discharges, too. With the selected configuration in a quadruple GEMstack the discharge probability is kept at the level of 10-12 discharges per incoming hadron. An overview of the ALICE TPC upgrade activities will be given in these proceedings and the optimised settings foreseen for the GEM stacks of the future readout chambers are introduced. Furthermore the outcome of two beam time campaigns at SPS and PS (at CERN) in the end of 2014 is shown. At this campaigns the stability against discharges and the dE/dx performance of a full size readout chamber prototype was tested. In addition it is reported on charging-up studies of 4GEM stacks and on tests of electromagnetic sagging of large GEM foils.

Michel electron reconstruction using cosmic-ray data from the MicroBooNE LArTPC

NASA Astrophysics Data System (ADS)

Acciarri, R.; Adams, C.; An, R.; Anthony, J.; Asaadi, J.; Auger, M.; Bagby, L.; Balasubramanian, S.; Baller, B.; Barnes, C.; Barr, G.; Bass, M.; Bay, F.; Bishai, M.; Blake, A.; Bolton, T.; Bugel, L.; Camilleri, L.; Caratelli, D.; Carls, B.; Castillo Fernandez, R.; Cavanna, F.; Chen, H.; Church, E.; Cianci, D.; Cohen, E.; Collin, G. H.; Conrad, J. M.; Convery, M.; Crespo-Anadón, J. I.; Del Tutto, M.; Devitt, D.; Dytman, S.; Eberly, B.; Ereditato, A.; Escudero Sanchez, L.; Esquivel, J.; Fleming, B. T.; Foreman, W.; Furmanski, A. P.; Garcia-Gamez, D.; Garvey, G. T.; Genty, V.; Goeldi, D.; Gollapinni, S.; Graf, N.; Gramellini, E.; Greenlee, H.; Grosso, R.; Guenette, R.; Hackenburg, A.; Hamilton, P.; Hen, O.; Hewes, J.; Hill, C.; Ho, J.; Horton-Smith, G.; Huang, E.-C.; James, C.; de Vries, J. Jan; Jen, C.-M.; Jiang, L.; Johnson, R. A.; Joshi, J.; Jostlein, H.; Kaleko, D.; Karagiorgi, G.; Ketchum, W.; Kirby, B.; Kirby, M.; Kobilarcik, T.; Kreslo, I.; Laube, A.; Li, Y.; Lister, A.; Littlejohn, B. R.; Lockwitz, S.; Lorca, D.; Louis, W. C.; Luethi, M.; Lundberg, B.; Luo, X.; Marchionni, A.; Mariani, C.; Marshall, J.; Martinez Caicedo, D. A.; Meddage, V.; Miceli, T.; Mills, G. B.; Moon, J.; Mooney, M.; Moore, C. D.; Mousseau, J.; Murrells, R.; Naples, D.; Nienaber, P.; Nowak, J.; Palamara, O.; Paolone, V.; Papavassiliou, V.; Pate, S. F.; Pavlovic, Z.; Piasetzky, E.; Porzio, D.; Pulliam, G.; Qian, X.; Raaf, J. L.; Rafique, A.; Rochester, L.; von Rohr, C. Rudolf; Russell, B.; Schmitz, D. W.; Schukraft, A.; Seligman, W.; Shaevitz, M. H.; Sinclair, J.; Snider, E. L.; Soderberg, M.; Söldner-Rembold, S.; Soleti, S. R.; Spentzouris, P.; Spitz, J.; St. John, J.; Strauss, T.; Sutton, K. A.; Szelc, A. M.; Tagg, N.; Terao, K.; Thomson, M.; Toups, M.; Tsai, Y.-T.; Tufanli, S.; Usher, T.; Van de Water, R. G.; Viren, B.; Weber, M.; Wickremasinghe, D. A.; Wolbers, S.; Wongjirad, T.; Woodruff, K.; Yang, T.; Yates, L.; Zeller, G. P.; Zennamo, J.; Zhang, C.

2017-09-01

The MicroBooNE liquid argon time projection chamber (LArTPC) has been taking data at Fermilab since 2015 collecting, in addition to neutrino beam, cosmic-ray muons. Results are presented on the reconstruction of Michel electrons produced by the decay at rest of cosmic-ray muons. Michel electrons are abundantly produced in the TPC, and given their well known energy spectrum can be used to study MicroBooNE's detector response to low-energy electrons (electrons with energies up to ~ 50 MeV). We describe the fully-automated algorithm developed to reconstruct Michel electrons, with which a sample of ~ 14,000 Michel electron candidates is obtained. Most of this article is dedicated to studying the impact of radiative photons produced by Michel electrons on the accuracy and resolution of their energy measurement. In this energy range, ionization and bremsstrahlung photon production contribute similarly to electron energy loss in argon, leading to a complex electron topology in the TPC. By profiling the performance of the reconstruction algorithm on simulation we show that the ability to identify and include energy deposited by radiative photons leads to a significant improvement in the energy measurement of low-energy electrons. The fractional energy resolution we measure improves from over 30% to ~ 20% when we attempt to include radiative photons in the reconstruction. These studies are relevant to a large number of analyses which aim to study neutrinos by measuring electrons produced by νe interactions over a broad energy range.

Michel Electron Reconstruction Using Cosmic-Ray Data from the MicroBooNE LArTPC

DOE PAGES

Acciarri, R.

2017-09-14

The MicroBooNE liquid argon time projection chamber (LArTPC) has been taking data at Fermilab since 2015 collecting, in addition to neutrino beam, cosmic-ray muons. Results are presented on the reconstruction of Michel electrons produced by the decay at rest of cosmic-ray muons. Michel electrons are abundantly produced in the TPC, and given their well known energy spectrum can be used to study MicroBooNE's detector response to low-energy electrons (electrons with energies up to ~50 MeV). We describe the fully-automated algorithm developed to reconstruct Michel electrons, with which a sample of ~14,000 Michel electron candidates is obtained. Most of this article is dedicated to studying the impact of radiative photons produced by Michel electrons on the accuracy and resolution of their energy measurement. In this energy range, ionization and bremsstrahlung photon production contribute similarly to electron energy loss in argon, leading to a complex electron topology in the TPC. By profiling the performance of the reconstruction algorithm on simulation we show that the ability to identify and include energy deposited by radiative photons leads to a significant improvement in the energy measurement of low-energy electrons. The fractional energy resolution we measure improves from over 30% to ~20% when we attempt to include radiative photons in the reconstruction. These studies are relevant to a large number of analyses which aim to study neutrinos by measuring electrons produced bymore » $$\

Exclusive Muon-Neutrino Charged Current Muon Plus Any Number of Protons Topologies In ArgoNeuT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Partyka, Kinga Anna

2013-01-01

Neutrinos remain among the least understood fundamental particles even after decades of study. As we enter the precision era o f neutrino measurements bigger and more sophisticated detectors have emerged. The leading candidate among them is a Liquid Argon Time Projection Chamber (LArTPC ) detector technology due to its bubble-like chamber imaging, superb background rejection and scalability. I t is a perfect candidate that w ill aim to answer the remaining questions of the nature o f neutrino and perhaps our existence. Studying neutrinos with a detector that employs detection via beautiful images o f neutrino interactions can be bothmore » illuminating and surprising. The analysis presented here takes the full advantage of the LArTPC power by exploiting the first topological analysis of charged current muon neutrino p + N p , muon and any number of protons, interactions with the ArgoNeuT LArTPC experiment on an argon target. The results presented here are the first that address the proton multiplicity at the vertex and the proton kinematics. This study also addresses the importance o f nuclear effects in neutrino interactions. Furthermore, the developed here reconstruction techniques present a significant step forward for this technology and can be employed in the future LArTPC detectors.« less

Action of aluminum, novel TPC1-type channel inhibitor, against salicylate-induced and cold-shock-induced calcium influx in tobacco BY-2 cells.

PubMed

Lin, Cun; Yu, Yawei; Kadono, Takashi; Iwata, Michiaki; Umemura, Kenji; Furuichi, Takuya; Kuse, Masaki; Isobe, Minoru; Yamamoto, Yoko; Matsumoto, Hideaki; Yoshizuka, Kazuharu; Kawano, Tomonori

2005-07-08

Previously, effect of Al ions on calcium signaling was assessed in tobacco cells expressing a Ca2+-monitoring luminescent protein, aequorin and a newly isolated putative plant Ca2+ channel protein from Arabidopsis thaliana, AtTPC1 (two-pore channel 1). TPC1 channels were shown to be the only channel known to be sensitive to Al and they are responsive to reactive oxygen species and cryptogein, a fungal elicitor protein. Thus, involvement of TPC1 channels in calcium signaling leading to development of plant defense mechanism has been suggested. Then, the use of Al as a specific inhibitor of TPC1-type plant calcium channels has been proposed. Here, using transgenic tobacco BY-2 cells expressing aequorin, we report on the evidence in support of the involvement of Al-sensitive signaling pathway requiring TPC1-type channel-dependent Ca2+ influx in response to salicylic acid, a key plant defense-inducing agent, but not to an elicitor prepared from the cell wall of rice blast disease fungus Magnaporthe grisea. In addition, involvement of Al-sensitive Ca2+ channels in response to cold shock was also tested. The data suggested that the elicitor used here induces the Ca2+ influx via Al-insensitive path, while salicylic acid and cold-shock-stimulate the influx of Ca2+ via Al-sensitive mechanism.

TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+.

PubMed

Pitt, Samantha J; Funnell, Tim M; Sitsapesan, Mano; Venturi, Elisa; Rietdorf, Katja; Ruas, Margarida; Ganesan, A; Gosain, Rajendra; Churchill, Grant C; Zhu, Michael X; Parrington, John; Galione, Antony; Sitsapesan, Rebecca

2010-11-05

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a molecule capable of initiating the release of intracellular Ca(2+) required for many essential cellular processes. Recent evidence links two-pore channels (TPCs) with NAADP-induced release of Ca(2+) from lysosome-like acidic organelles; however, there has been no direct demonstration that TPCs can act as NAADP-sensitive Ca(2+) release channels. Controversial evidence also proposes ryanodine receptors as the primary target of NAADP. We show that TPC2, the major lysosomal targeted isoform, is a cation channel with selectivity for Ca(2+) that will enable it to act as a Ca(2+) release channel in the cellular environment. NAADP opens TPC2 channels in a concentration-dependent manner, binding to high affinity activation and low affinity inhibition sites. At the core of this process is the luminal environment of the channel. The sensitivity of TPC2 to NAADP is steeply dependent on the luminal [Ca(2+)] allowing extremely low levels of NAADP to open the channel. In parallel, luminal pH controls NAADP affinity for TPC2 by switching from reversible activation of TPC2 at low pH to irreversible activation at neutral pH. Further evidence earmarking TPCs as the likely pathway for NAADP-induced intracellular Ca(2+) release is obtained from the use of Ned-19, the selective blocker of cellular NAADP-induced Ca(2+) release. Ned-19 antagonizes NAADP-activation of TPC2 in a non-competitive manner at 1 μM but potentiates NAADP activation at nanomolar concentrations. This single-channel study provides a long awaited molecular basis for the peculiar mechanistic features of NAADP signaling and a framework for understanding how NAADP can mediate key physiological events.

Performance of 20:1 multiplexer for large area charge readouts in directional dark matter TPC detectors

NASA Astrophysics Data System (ADS)

Ezeribe, A. C.; Robinson, M.; Robinson, N.; Scarff, A.; Spooner, N. J. C.; Yuriev, L.

2018-02-01

More target mass is required in current TPC based directional dark matter detectors for improved detector sensitivity. This can be achieved by scaling up the detector volumes, but this results in the need for more analogue signal channels. A possible solution to reducing the overall cost of the charge readout electronics is to multiplex the signal readout channels. Here, we present a multiplexer system in expanded mode based on LMH6574 chips produced by Texas Instruments, originally designed for video processing. The setup has a capability of reducing the number of readouts in such TPC detectors by a factor of 20. Results indicate that the important charge distribution asymmetry along an ionization track is retained after multiplexed signals are demultiplexed.

Study of a Large Prototype TPC for the ILC using Micro-Pattern Gas Detectors

NASA Astrophysics Data System (ADS)

Münnich, A.; LCTPC Collaboration

2016-04-01

In the last decade, R&D for detectors for the future International Linear Collider (ILC) has been performed by the community. The International Large Detector (ILD) is one of two detector concepts at the ILC. Its tracking system consists of a Si vertex detector, forward tracking disks and a large volume Time Projection Chamber (TPC). Within the LCTPC collaboration, a Large Prototype (LP) TPC has been built as a demonstrator. Its endplate is able to house up to seven identical modules with Micro-Pattern Gas Detectors (MPGD) amplification. Recently, the LP has been equipped with resistive anode Micromegas (MM) or Gas Electron Multiplier (GEM) modules. Both the MM and GEM technologies have been studied with an electron beam up to 6 GeV in a 1 Tesla solenoid magnet. After introducing the current R&D status, recent results will be presented including field distortions, ion gating and spatial resolution as well as future plans of the LCTPC R&D.

Rebuttal to comment on “Modeling of opposition effects with ensembles of clusters: Interplay of various scattering mechanisms” by Elena V. Petrova, Victor P. Tishkovets, Klaus Jockers, 2007 [Icarus 188, 233 245

NASA Astrophysics Data System (ADS)

Petrova, Elena V.; Tishkovets, Victor P.; Jockers, Klaus

2008-04-01

Shkuratov and Zubko [Shkuratov, Yu.G., Zubko, E., 2008. Icarus 194, 850-852] criticize our paper [Petrova, E.V., Tishkovets, V.P., Jockers, K., 2007. Icarus 188, 233-245]. With this comment we reply to this criticism. We show that the experimental data and the modeling calculations presented by these authors cannot disprove the near-field effect as an important contributor to the scattering mechanisms considered in our paper.

Design and implementation of wire tension measurement system for MWPCs used in the STAR iTPC upgrade

NASA Astrophysics Data System (ADS)

Wang, Xu; Shen, Fuwang; Wang, Shuai; Feng, Cunfeng; Li, Changyu; Lu, Peng; Thomas, Jim; Xu, Qinghua; Zhu, Chengguang

2017-07-01

The STAR experiment at RHIC is planning to upgrade the Time Projection Chamber which lies at the heart of the detector. We have designed an instrument to measure the tension of the wires in the multi-wire proportional chambers (MWPCs) which will be used in the TPC upgrade. The wire tension measurement system causes the wires to vibrate and then it measures the fundamental frequency of the oscillation via a laser based optical platform. The platform can scan the entire wire plane, automatically, in a single run and obtain the wire tension on each wire with high precision. In this paper, the details about the measurement method and the system setup will be described. In addition, the test results for a prototype MWPC to be used in the STAR-iTPC upgrade will be presented.

Secular perihelion advances of the inner planets and asteroid Icarus

NASA Astrophysics Data System (ADS)

Wilhelm, Klaus; Dwivedi, Bhola N.

2014-08-01

A small effect expected from a recently proposed gravitational impact model (Wilhelm et al., 2013) is used to explain the remaining secular perihelion advance rates of the planets Mercury, Venus, Earth, Mars, and the asteroid (1566) Icarus-after taking into account the disturbances related to Newton’s Theory of Gravity. Such a rate was discovered by Le Verrier (1859) for Mercury and calculated by Einstein (1915, 1916) in the framework of his General Theory of Relativity (GTR). Accurate observations are now available for the inner Solar System objects with different orbital parameters. This is important, because it allowed us to demonstrate that the quantitative amount of the deviation from an 1/r potential is-under certain conditions-only dependent on the specific mass distribution of the Sun and not on the characteristics of the orbiting objects and their orbits. A displacement of the effective gravitational from the geometric centre of the Sun by about 4400 m towards each object is consistent with the observations and explains the secular perihelion advance rates.

Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization From Acidic Stores in Pancreatic α-Cells.

PubMed

Hamilton, Alexander; Zhang, Quan; Salehi, Albert; Willems, Mara; Knudsen, Jakob G; Ringgaard, Anna K; Chapman, Caroline E; Gonzalez-Alvarez, Alejandro; Surdo, Nicoletta C; Zaccolo, Manuela; Basco, Davide; Johnson, Paul R V; Ramracheya, Reshma; Rutter, Guy A; Galione, Antony; Rorsman, Patrik; Tarasov, Andrei I

2018-06-01

Adrenaline is a powerful stimulus of glucagon secretion. It acts by activation of β-adrenergic receptors, but the downstream mechanisms have only been partially elucidated. Here, we have examined the effects of adrenaline in mouse and human α-cells by a combination of electrophysiology, imaging of Ca 2+ and PKA activity, and hormone release measurements. We found that stimulation of glucagon secretion correlated with a PKA- and EPAC2-dependent (inhibited by PKI and ESI-05, respectively) elevation of [Ca 2+ ] i in α-cells, which occurred without stimulation of electrical activity and persisted in the absence of extracellular Ca 2+ but was sensitive to ryanodine, bafilomycin, and thapsigargin. Adrenaline also increased [Ca 2+ ] i in α-cells in human islets. Genetic or pharmacological inhibition of the Tpc2 channel (that mediates Ca 2+ release from acidic intracellular stores) abolished the stimulatory effect of adrenaline on glucagon secretion and reduced the elevation of [Ca 2+ ] i Furthermore, in Tpc2-deficient islets, ryanodine exerted no additive inhibitory effect. These data suggest that β-adrenergic stimulation of glucagon secretion is controlled by a hierarchy of [Ca 2+ ] i signaling in the α-cell that is initiated by cAMP-induced Tpc2-dependent Ca 2+ release from the acidic stores and further amplified by Ca 2+ -induced Ca 2+ release from the sarco/endoplasmic reticulum. © 2018 by the American Diabetes Association.

Design and implementation of wire tension measurement system for MWPCs used in the STAR iTPC upgrade

DOE PAGES

Wang, Xu; Shen, Fuwang; Wang, Shuai; ...

2017-04-06

The STAR experiment at RHIC is planning to upgrade the Time Projection Chamber which lies at the heart of the detector. We have designed an instrument to measure the tension of the wires in the multi-wire proportional chambers (MWPCs) which will be used in the TPC upgrade. The wire tension measurement system causes the wires to vibrate and then it measures the fundamental frequency of the oscillation via a laser based optical platform. The platform can scan the entire wire plane, automatically, in a single run and obtain the wire tension on each wire with high precision. In this paper,more » the details about the measurement method and the system setup will be described. In addition, the test results for a prototype MWPC to be used in the STAR-iTPC upgrade will be presented.« less

Topological signature in the NEXT high pressure xenon TPC

NASA Astrophysics Data System (ADS)

Ferrario, Paola; NEXT Collaboration

2017-09-01

The NEXT experiment aims to observe the neutrinoless double beta decay of 136Xe in a high-pressure xenon gas TPC using electroluminescence to amplify the signal from ionization. One of the main advantages of this technology is the possibility to use the topology of events with energies close to Qββ as an extra tool to reject background. In these proceedings we show with data from prototypes that an extra background rejection factor of 24.3 ± 1.4 (stat.)% can be achieved, while maintaining an efficiency of 66.7 ± 1.% for signal events. The performance expected in NEW, the next stage of the experiment, is to improve to 12.9% ± 0.6% background acceptance for 66.9% ± 0.6% signal efficiency.

The Origins and Evolution of the Time Projection Chamber (TPC) Idea

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nygren, David

In February 1974, I conceived an idea for a tracking detector with only one spatial projection, thereby eliminating ambiguities that occur in conventional detector systems based on wires. I called it the “Time Projection Chamber”, or TPC, a name that has stuck even though the concept has evolved considerably over the following decades. I will recount the history leading to its conception and development in that now distant epoch, and will attempt to show why this is an interesting and instructive story and how the idea may continue to extend scientific reach in the coming era.

Comparative study of the effects of solid-state fermentation with three filamentous fungi on the total phenolics content (TPC), flavonoids, and antioxidant activities of subfractions from oats (Avena sativa L.).

PubMed

Cai, Shengbao; Wang, Ou; Wu, Wei; Zhu, Songjie; Zhou, Feng; Ji, Baoping; Gao, Fengyi; Zhang, Di; Liu, Jia; Cheng, Qian

2012-01-11

The aim of present work was to investigate the effect of solid-state fermentation with filamentous fungi (Aspergillus oryzae var. effuses, Aspergillus oryzae, and Aspergillus niger) on total phenolics content (TPC), flavonoids, and antioxidant activities of four subfractions of oat, namely, n-hexane, ethyl acetate (EA), n-butanol, and water, and compare them to their corresponding subfractions of unfermented oat. The TPC and total flavonoids increased dramatically, especially in EA subfractions (p < 0.05). The levels of antioxidant activity of subfractions were also significantly enhanced (p < 0.05). The highest antioxidant activities were also found in the EA subfractions. The polyphenols in EA were analyzed by high-performance liquid chromatography at 280 nm. Most polyphenols were increased remarkably, especially ferulic and caffeic acids. There was a clear correlation between the TPC and antioxidant activity. In conclusion, fungi fermentation is a potential bioprocess for increasing the TPC, flavonoids, and antioxidant activities of oat-based food.

Measuring Fission Fragment Mass Distributions as a Function of Incident Neutron Energy Using the fissionTPC

NASA Astrophysics Data System (ADS)

Gearhart, Joshua; Niffte Collaboration

2017-09-01

Fission fragment mass distributions are important observables for developing next generation dynamical models of fission. Many previous measurements have utilized ionization chambers to measure fission fragment energies and emission angles which are then used for mass calculations. The Neutron Induced Fission Fragment Tracking Experiment (NIFFTE) collaboration has built a time projection chamber (fissionTPC) that is capable of measuring additional quantities such as the ionization profiles of detected particles, allowing for the association of an individual fragment's ionization profile with its mass. The fragment masses are measured using the previously established 2E method. The fissionTPC takes its data using a continuous incident neutron energy spectrum provided by the Los Alamos Neutron Science CEnter (LANSCE). Mass distribution measurements across a continuous range of neutron energies put stronger constraints on fission models than similar measurements conducted at a handful of discrete neutron energies. This material is based upon work supported by the Department of Energy National Nuclear Security Administration under Award Numbers DE-NA0003180 and DE-NA0002921.

GEM-based TPC with CCD imaging for directional dark matter detection

NASA Astrophysics Data System (ADS)

Phan, N. S.; Lauer, R. J.; Lee, E. R.; Loomba, D.; Matthews, J. A. J.; Miller, E. H.

2016-11-01

The most mature directional dark matter experiments at present all utilize low-pressure gas Time Projection Chamber (TPC) technologies. We discuss some of the challenges for this technology, for which balancing the goal of achieving the best sensitivity with that of cost effective scale-up requires optimization over a large parameter space. Critical for this are the precision measurements of the fundamental properties of both electron and nuclear recoil tracks down to the lowest detectable energies. Such measurements are necessary to provide a benchmark for background discrimination and directional sensitivity that could be used for future optimization studies for directional dark matter experiments. In this paper we describe a small, high resolution, high signal-to-noise GEM-based TPC with a 2D CCD readout designed for this goal. The performance of the detector was characterized using alpha particles, X-rays, gamma-rays, and neutrons, enabling detailed measurements of electron and nuclear recoil tracks. Stable effective gas gains of greater than 1 × 105 were obtained in 100 Torr of pure CF4 by a cascade of three standard CERN GEMs each with a 140 μm pitch. The high signal-to-noise and sub-millimeter spatial resolution of the GEM amplification and CCD readout, together with low diffusion, allow for excellent background discrimination between electron and nuclear recoils down below ∼10 keVee (∼23 keVr fluorine recoil). Even lower thresholds, necessary for the detection of low mass WIMPs for example, might be achieved by lowering the pressure and utilizing full 3D track reconstruction. These and other paths for improvements are discussed, as are possible fundamental limitations imposed by the physics of energy loss.

Neutron Fluence and Energy Reconstruction with the LNE-IRSN/MIMAC Recoil Detector MicroTPC at 27 keV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maire, D.; Lebreton, L.; Querre, Ph.

2015-07-01

The French Institute for Radiation protection and Nuclear Safety (IRSN), designated by the French Metrology Institute (LNE) for neutron metrology, is developing a time projection chamber using a Micromegas anode: microTPC. This work is carried out in collaboration with the Laboratory of Subatomic Physics and Cosmology (LPSC). The aim is to characterize the energy distribution of neutron fluence in the energy range 8 keV - 5 MeV with a primary procedure. The time projection chambers are gaseous detectors able to measure charged particles energy and to reconstruct their track if a pixelated anode is used. In our case, the gasmore » is used as a (n, p) converter in order to detect neutrons down to few keV. Coming from elastic collisions with neutrons, recoil protons lose a part of their kinetic energy by ionizing the gas. The ionization electrons are drifted toward a pixelated anode (2D projection), read at 50 MHz by a self-triggered electronic system to obtain the third track dimension. The neutron energy is reconstructed event by event thanks to proton scattering angle and proton energy measurements. The scattering angle is deduced from the 3D track. The proton energy is obtained by charge collection measurements, knowing the ionization quenching factor (i.e. the part of proton kinetic energy lost by ionizing the gas). The fluence is calculated thanks to the detected events number and the simulation of the detector response. The μTPC is a new reliable detector able to measure energy distribution of the neutron fluence without unfolding procedure or prior neutron calibration contrary to usual gaseous counters. The microTPC is still being developed and measurements have been carried out at the AMANDE facility, with neutrons energies going from 8 keV to 565 keV. After the context and the μ-TPC working principle presentation, measurements of the neutron energy and fluence at 27 keV and 144 keV are shown and compared to the complete detector response simulation. This

Development of a dedicated readout ASIC for TPC based X-ray polarimeter

NASA Astrophysics Data System (ADS)

Zhang, Hongyan; Deng, Zhi; Li, Hong; Liu, Yinong; Feng, Hua

2016-07-01

X-ray polarimetry with time projection chambers was firstly proposed by JK Black in 2007 and has been greatly developed since then. It measured two dimensional photoelectron tracks with one dimensional strip and the other dimension was estimated by the drift time from the signal waveforms. A readout ASIC, APV25, originally developed for CMS silicon trackers was used and has shown some limitations such as waveform sampling depth. A dedicated ASIC was developed for TPC based X-ray polarimeters in this paper. It integrated 32 channel circuits and each channel consisted of an analog front-end and a waveform sampler based on switched capacitor array. The analog front-end has a charge sensitive preamplifier with a gain of 25 mV/fC, a CR-RC shaper with a peaking time of 25 ns, a baseline holder and a discriminator for self-triggering. The SCA has a buffer latency of 3.2 μs with 64 cells operating at 20 MSPS. The ASIC was fabricated in a 0.18 μm CMOS process. The equivalent noise charge (ENC) of the analog front-end was measured to be 274.8 e+34.6 e/pF. The effective resolution of the SCA was 8.8 bits at sampling rate up to 50 MSPS. The total power consumption was 2.8 mW per channel. The ASIC was also tested with real TPC detectors and two dimensional photoelectron tracks have been successfully acquired. More tests and analysis on the sensitivity to the polarimetry are undergoing and will be presented in this paper.

Large Area Coverage of a TPC Endcap with GridPix Detectors

NASA Astrophysics Data System (ADS)

Kaminski, Jochen

2018-02-01

The Large Prototype TPC at DESY, Hamburg, was built by the LCTPC collaboration as a testbed for new readout technologies of Time Projection Chambers. Up to seven modules of about 400 cm2 each can be placed in the endcap. Three of these modules were equipped with a total of 160 GridPix detectors. This is a combination of a highly pixelated readout ASIC and a Micromegas built on top. GridPix detectors have a very high efficiency of detecting primary electrons, which leads to excellent spatial and energy resolutions. For the first time a large number of GridPix detectors has been operated and long segments of tracks have been recorded with excellent precision.

76 FR 28914 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-19

... of the rudder system design. Rudder pedal sensitivity on Model A300-600 and A310 series airplanes is... B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R Variant F Airplanes (Collectively Called A300-600 Series Airplanes); and Model A310 Series Airplanes AGENCY: Federal Aviation...

A ROS-Assisted Calcium Wave Dependent on the AtRBOHD NADPH Oxidase and TPC1 Cation Channel Propagates the Systemic Response to Salt Stress.

PubMed

Evans, Matthew J; Choi, Won-Gyu; Gilroy, Simon; Morris, Richard J

2016-07-01

Plants exhibit rapid, systemic signaling systems that allow them to coordinate physiological and developmental responses throughout the plant body, even to highly localized and quickly changing environmental stresses. The propagation of these signals is thought to include processes ranging from electrical and hydraulic networks to waves of reactive oxygen species (ROS) and cytoplasmic Ca(2+) traveling throughout the plant. For the Ca(2+) wave system, the involvement of the vacuolar ion channel TWO PORE CHANNEL1 (TPC1) has been reported. However, the precise role of this channel and the mechanism of cell-to-cell propagation of the wave have remained largely undefined. Here, we use the fire-diffuse-fire model to analyze the behavior of a Ca(2+) wave originating from Ca(2+) release involving the TPC1 channel in Arabidopsis (Arabidopsis thaliana). We conclude that a Ca(2+) diffusion-dominated calcium-induced calcium-release mechanism is insufficient to explain the observed wave transmission speeds. The addition of a ROS-triggered element, however, is able to quantitatively reproduce the observed transmission characteristics. The treatment of roots with the ROS scavenger ascorbate and the NADPH oxidase inhibitor diphenyliodonium and analysis of Ca(2+) wave propagation in the Arabidopsis respiratory burst oxidase homolog D (AtrbohD) knockout background all led to reductions in Ca(2+) wave transmission speeds consistent with this model. Furthermore, imaging of extracellular ROS production revealed a systemic spread of ROS release that is dependent on both AtRBOHD and TPC1 These results suggest that, in the root, plant systemic signaling is supported by a ROS-assisted calcium-induced calcium-release mechanism intimately involving ROS production by AtRBOHD and Ca(2+) release dependent on the vacuolar channel TPC1. © 2016 American Society of Plant Biologists. All Rights Reserved.

75 FR 8461 - Airworthiness Directives; Bombardier, Inc. Model CL-600-1A11 (CL-600), CL-600-2A12 (CL-601), and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-25

... Model CL-600-1A11 AFM (Winglets). These two TRs are approved by TCCA, and should be replaced in AD 2009... the Canadair Challenger Model CL-600-1A11 AFM (Winglets). We agreed and proposed to revise Table 2 of...) 600-1/17 August 16, 2006.. Canadair Challenger Model CL-600-1A11 AFM (Winglets). (iii) 601/14 August...

Operation of a LAr-TPC equipped with a multilayer LEM charge readout

DOE PAGES

Baibussinov, B.; Centro, S.; Farnese, C.; ...

2018-03-01

A novel detector for ionization signals in a single phase LAr-TPC has been experimented in the ICARINO test facility at the INFN Laboratories in Legnaro. It is based on the adoption of a multilayer Large Electron Multiplier (LEM) replacing the traditional anodic wire arrays. Cosmic muon tracks were detected allowing the measurement of energy deposition and a first determination of the signal to noise ratio. The analysis of the recorded events thus demonstrated the 3D reconstruction capability of this device for ionizing events in liquid Argon. The collected fraction of ionization charge is close to about 90%, with signal tomore » noise ratio similar to that measured with more traditional wire chambers.« less

Operation of a LAr-TPC equipped with a multilayer LEM charge readout

NASA Astrophysics Data System (ADS)

Baibussinov, B.; Centro, S.; Farnese, C.; Fava, A.; Gibin, D.; Guglielmi, A.; Meng, G.; Pietropaolo, F.; Varanini, F.; Ventura, S.; Zatrimaylov, K.

2018-03-01

A novel detector for ionization signals in a single phase LAr-TPC has been experimented in the ICARINO test facility at the INFN Laboratories in Legnaro. It is based on the adoption of a multilayer Large Electron Multiplier (LEM) replacing the traditional anodic wire arrays. Cosmic muon tracks were detected allowing the measurement of energy deposition and a first determination of the signal to noise ratio. The analysis of the recorded events demonstrated the 3D reconstruction capability of this device for ionizing events in liquid Argon. The collected fraction of ionization charge is close to about 90%, with signal to noise ratio similar to that measured with more traditional wire chambers.

Operation of a LAr-TPC equipped with a multilayer LEM charge readout

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baibussinov, B.; Centro, S.; Farnese, C.

A novel detector for ionization signals in a single phase LAr-TPC has been experimented in the ICARINO test facility at the INFN Laboratories in Legnaro. It is based on the adoption of a multilayer Large Electron Multiplier (LEM) replacing the traditional anodic wire arrays. Cosmic muon tracks were detected allowing the measurement of energy deposition and a first determination of the signal to noise ratio. The analysis of the recorded events thus demonstrated the 3D reconstruction capability of this device for ionizing events in liquid Argon. The collected fraction of ionization charge is close to about 90%, with signal tomore » noise ratio similar to that measured with more traditional wire chambers.« less

Project Icarus: The First Unmanned Interstellar Mission - Robotic Expansion and Technological Growth

NASA Astrophysics Data System (ADS)

Long, K. F.

This paper discusses the important role of `disruptive technology' in altering the assessment on when the first unmanned interstellar probe mission is possible. Historical estimates suggest that such a mission is likely possible in the 23rd or 24th century. This paper argues that if such assessments also consider the role of high-growth exponential technology trends then in fact the first unmanned mission may be possible much earlier. The case study of a 100 year flyby space probe mission to Alpha Centauri 4.3 light years distance is examined, with an ideal cruise speed of 2,700 AU/year. Starting from an assumed mission capacity of 5 AU/year in 2020 a simple assessment shows that assuming a greater than ~8% technology growth annually in mission capacity (as measured by the attainment of cruise speed) it may be possible to launch an interstellar probe by around the year 2100. This depends upon significant and sustained science and technology research investment being made, particularly into space propulsion engineering in the near-term. This paper is a submission of the Project Icarus Study Group.

Usefulness of immunohistochemistry for the detection of the BRAF V600E mutation in Japanese lung adenocarcinoma.

PubMed

Sasaki, Hidefumi; Shimizu, Shigeki; Tani, Yoichi; Shitara, Masayuki; Okuda, Katsuhiro; Hikosaka, Yu; Moriyama, Satoru; Yano, Motoki; Fujii, Yoshitaka

2013-10-01

Mutations in components of the mitogen-activated protein kinase (MAPK) cascade may be a new candidate for target for lung cancer. The usefulness of immunohistochemistry (IHC) as a new approach for the detection of BRAF V600E in cancer patients has been recently reported. To increase the sensitivity, we modified BRAF V600E expression detection assay by IHC using mutation specific antibody. From the screening step, we found a novel 599 insertion T BRAF mutation in lung adenocarcinoma. In this study included 26 surgically removed cases with EGFR, Kras, erbB2, EML4-ALK and KIF5B-RET wild-type (wt) lung adenocarcinomas, including 7 BRAF mutants (5 V600E, 1 N581I, and 1 novel 599 insertion T mutation) analyzed by DNA sequencing. Detection of the BRAF V600E mutation was carried out by the Dako EnVision™ FLEX detection system using the VE1 clone antibody and compared with the results of direct sequencing. The autostainer IHC VE1 assay was positive in 5 of 5 (100%) BRAF V600E-mutated tumors and negative in 20 of 21 (95.2%) BRAF non-V600E tumors, except for a novel 599 insertion T case. IHC using the VE1 clone and FLEX linker is a specific method for the detection BRAF V600E and may be an alternative to molecular biology for the detection of mutations in lung adenocarcinomas. This method might be useful for screening to use molecular target therapy for lung adenocarcinomas. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

76 FR 6581 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-07

... B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R Variant F Airplanes (Collectively Called A300-600 Series Airplanes) AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of... design review against explosion risks. During improvement of the protection of fuel pump wiring against...

76 FR 27242 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-11

... Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R Variant F Airplanes (Collectively Called A300-600 Series Airplanes) AGENCY: Federal Aviation... required to conduct a design review against explosion risks. During improvement of the protection of fuel...

75 FR 60611 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-01

... Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and Model A300 C4...; Model A300 B4-601, B4- 603, B4-620, B4-622, B4-605R, B4-622R, F4-605R, F4-622R, and C4-605R Variant F...-- Dated-- A300 series airplanes......... A300-32A0447..... April 22, 2004. A300 B4-600, B4-600R, and F4...

BRAFV600E Negatively Regulates the AKT Pathway in Melanoma Cell Lines

PubMed Central

Chen, Brenden; Tardell, Christine; Higgins, Brian; Packman, Kathryn; Boylan, John F.; Niu, Huifeng

2012-01-01

Cross-feedback activation of MAPK and AKT pathways is implicated as a resistance mechanism for cancer therapeutic agents targeting either RAF/MEK or PI3K/AKT/mTOR. It is thus important to have a better understanding of the molecular resistance mechanisms to improve patient survival benefit from these agents. Here we show that BRAFV600E is a negative regulator of the AKT pathway. Expression of BRAFV600E in NIH3T3 cells significantly suppresses MEK inhibitor (RG7167) or mTORC1 inhibitor (rapamycin) induced AKT phosphorylation (pAKT) and downstream signal activation. Treatment-induced pAKT elevation is found in BRAF wild type melanoma cells but not in a subset of melanoma cell lines harboring BRAFV600E. Knock-down of BRAFV600E in these melanoma cells elevates basal pAKT and downstream signals, whereas knock-down of CRAF, MEK1/2 or ERK1/2 or treatment with a BRAF inhibitor have no impact on pAKT. Mechanistically, we show that BRAFV600E interacts with rictor complex (mTORC2) and regulates pAKT through mTORC2. BRAFV600E is identified in mTORC2 after immunoprecipitation of rictor. Knock-down of rictor abrogates BRAFV600E depletion induced pAKT. Knock-down of BRAFV600E enhances cellular enzyme activity of mTORC2. Aberrant activation of AKT pathway by PTEN loss appears to override the negative impact of BRAFV600E on pAKT. Taken together, our findings suggest that in a subset of BRAFV600E melanoma cells, BRAFV600E negatively regulates AKT pathway in a rictor-dependent, MEK/ERK and BRAF kinase-independent manner. Our study reveals a novel molecular mechanism underlying the regulation of feedback loops between the MAPK and AKT pathways. PMID:22880048

BRAFV600E negatively regulates the AKT pathway in melanoma cell lines.

PubMed

Chen, Brenden; Tardell, Christine; Higgins, Brian; Packman, Kathryn; Boylan, John F; Niu, Huifeng

2012-01-01

Cross-feedback activation of MAPK and AKT pathways is implicated as a resistance mechanism for cancer therapeutic agents targeting either RAF/MEK or PI3K/AKT/mTOR. It is thus important to have a better understanding of the molecular resistance mechanisms to improve patient survival benefit from these agents. Here we show that BRAFV600E is a negative regulator of the AKT pathway. Expression of BRAFV600E in NIH3T3 cells significantly suppresses MEK inhibitor (RG7167) or mTORC1 inhibitor (rapamycin) induced AKT phosphorylation (pAKT) and downstream signal activation. Treatment-induced pAKT elevation is found in BRAF wild type melanoma cells but not in a subset of melanoma cell lines harboring BRAFV600E. Knock-down of BRAFV600E in these melanoma cells elevates basal pAKT and downstream signals, whereas knock-down of CRAF, MEK1/2 or ERK1/2 or treatment with a BRAF inhibitor have no impact on pAKT. Mechanistically, we show that BRAFV600E interacts with rictor complex (mTORC2) and regulates pAKT through mTORC2. BRAFV600E is identified in mTORC2 after immunoprecipitation of rictor. Knock-down of rictor abrogates BRAFV600E depletion induced pAKT. Knock-down of BRAFV600E enhances cellular enzyme activity of mTORC2. Aberrant activation of AKT pathway by PTEN loss appears to override the negative impact of BRAFV600E on pAKT. Taken together, our findings suggest that in a subset of BRAFV600E melanoma cells, BRAFV600E negatively regulates AKT pathway in a rictor-dependent, MEK/ERK and BRAF kinase-independent manner. Our study reveals a novel molecular mechanism underlying the regulation of feedback loops between the MAPK and AKT pathways.

Measurement of the ( p, , T) Properties for Pure Hydrocarbons at Temperatures up to 600 K and Pressures up to 200 MPa

NASA Astrophysics Data System (ADS)

Ito, T.; Nagata, Y.; Miyamoto, H.

2014-10-01

The data available for the thermodynamic properties of propane, -butane, and isobutane at temperatures above 440 K are outdated and show significant discrepancies with each other. The ambiguity associated with these data could be limiting to the development of any understanding related to the effects of mixing of these substances with other materials such as , ammonia, and non-flammable or lower-flammable HFC refrigerants. In this study, the ( p, , T) properties of propane, -butane, and isobutane were measured at temperatures ranging from (360 to 600) K and pressures ranging from (50 to 200) MPa. Precise measurements were carried out using a metal-bellows variable volumometer with a thermostatted air bath. The expanded uncertainties in the temperature, pressure, and density measurements were estimated to be 5 mK, 0.02 MPa, and 0.88 kg m ( K, MPa), 0.76 kg ( K, MPa), 0.76 kg ( K, MPa), and 2.94 kg ( K, MPa), respectively. The data obtained throughout this study were systematically compared with the calculated values derived from the available equations of state. These models agree well with the measured data at higher temperatures up to 600 K, demonstrating their suitability for an effective and precise examination of the mixing effects of potential alternative mixtures.

CCD Photometer Installed on the Telescope - 600 OF the Shamakhy Astrophysical Observatory: I. Adjustment of CCD Photometer with Optics - 600

NASA Astrophysics Data System (ADS)

Lyuty, V. M.; Abdullayev, B. I.; Alekberov, I. A.; Gulmaliyev, N. I.; Mikayilov, Kh. M.; Rustamov, B. N.

2009-12-01

Short description of optical and electric scheme of CCD photometer with camera U-47 installed on the Cassegrain focus of ZEISS-600 telescope of the ShAO NAS Azerbaijan is provided. The reducer of focus with factor of reduction 1.7 is applied. It is calculated equivalent focal distances of a telescope with a focus reducer. General calculations of optimum distance from focal plane and t sizes of optical filters of photometer are presented.

Uncivilizing "Mental Illness": Contextualizing Diverse Mental States and Posthuman Emotional Ecologies within The Icarus Project.

PubMed

Fletcher, Erica Hua

2018-03-01

This article argues humans should not be defined strictly at their physical boundaries with clear distinctions between anatomical bodies, mental states, and the rest of the world. Rather, diverse mental states, which are often diagnosed as "mental illness," take shape within greater environmental forces and flows, including those that are constructed online. Drawing from a multi-sited ethnography of The Icarus Project, a radical mental health community, the author situates online narratives written by two of its members within posthuman emotional ecologies in which the exchange of ideas online affects mental states in a profound way. These narratives can be seen as a new type of psychiatric resistance based in new technologies, one that "uncivilizes" mental illness by searching for alternative frameworks and metaphors to understand lived experiences with mental distress. This ethnographic perspective differs significantly from traditional bio-psychiatric models and interventions and can offer both patients and mental healthcare providers with an alternative language to frame mental health.

75 FR 6862 - Airworthiness Directives; Bombardier, Inc. Model CL-600-1A11 (CL-600), CL-600-2A12 (CL-601), CL...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-12

... hydraulic accumulator screw cap or end cap failure have been experienced on CL-600-2B19 (CRJ) aircraft... experienced on CL-600-2B19 (CRJ) aircraft, resulting in loss of the associated hydraulic system and high... on CL-600-2B19 (CRJ) aircraft, resulting in loss of the associated hydraulic system and high-energy...

40 CFR 600.011-93 - Reference materials.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Standard Test Method for Heat of Combustion of Liquid Hydrocarbon Fuels by Bomb Calorimeter 600.113-93, 600... Hydrocarbon Fuels by Bomb Calorimeter, IBR approved for §§ 600.113-93, 600.510-93, 600.113-08, and 600.510-08...

50 CFR 600.227 - Lobbying.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Lobbying. 600.227 Section 600.227 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.227 Lobbying. (a) Council...

50 CFR 600.230 - Removal.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Removal. 600.230 Section 600.230 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.230 Removal. The Secretary...

50 CFR 600.134 - Stipends.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Stipends. 600.134 Section 600.134 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Regional Fishery Management Councils § 600.134...

50 CFR 600.710 - Permits.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Permits. 600.710 Section 600.710 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS General Provisions for Domestic Fisheries § 600.710...

50 CFR 600.517 - Allocations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Allocations. 600.517 Section 600.517 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.517 Allocations. The Secretary...

50 CFR 600.230 - Removal.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Removal. 600.230 Section 600.230 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.230 Removal. The Secretary...

50 CFR 600.134 - Stipends.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Stipends. 600.134 Section 600.134 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Regional Fishery Management Councils § 600.134...

50 CFR 600.746 - Observers.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Observers. 600.746 Section 600.746 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS General Provisions for Domestic Fisheries § 600.746...

50 CFR 600.134 - Stipends.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Stipends. 600.134 Section 600.134 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Regional Fishery Management Councils § 600.134...

50 CFR 600.735 - Penalties.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Penalties. 600.735 Section 600.735 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS General Provisions for Domestic Fisheries § 600.735...

50 CFR 600.227 - Lobbying.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Lobbying. 600.227 Section 600.227 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.227 Lobbying. (a) Council...

50 CFR 600.1016 - Enforcement.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Enforcement. 600.1016 Section 600.1016 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Fishing Capacity Reduction Framework § 600.1016...

50 CFR 600.1016 - Enforcement.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Enforcement. 600.1016 Section 600.1016 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Fishing Capacity Reduction Framework § 600.1016...

44 CFR 17.600 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Purpose. 17.600 Section 17.600 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) § 17.600 Purpose. (a) The...

40 CFR 600.003 - Abbreviations.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 31 2013-07-01 2013-07-01 false Abbreviations. 600.003 Section 600.003 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES General Provisions § 600.003 Abbreviations. The...

40 CFR 600.003 - Abbreviations.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Abbreviations. 600.003 Section 600.003 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES General Provisions § 600.003 Abbreviations. The...

40 CFR 600.003 - Abbreviations.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Abbreviations. 600.003 Section 600.003 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES General Provisions § 600.003 Abbreviations. The...

Performance of a MICROMEGAS-based TPC in a high-energy neutron beam

DOE PAGES

Snyder, L.; Manning, B.; Bowden, N. S.; ...

2017-11-01

The MICROMEGAS (MICRO-MEsh GAseous Structure) charge amplification structure has found wide use in many detection applications, especially as a gain stage for the charge readout of Time Projection Chambers (TPCs). We report on the behavior of a MICROMEGAS TPC when operated in a high-energy (up to 800 MeV) neutron beam. It is found that neutron-induced reactions can cause discharges in some drift gas mixtures that are stable in the absence of the neutron beam. The discharges result from recoil ions close to the MICROMEGAS that deposit high specific ionization density and have a limited diffusion time. And for a binarymore » drift gas, increasing the percentage of the molecular component (quench gas) relative to the noble component and operating at lower pressures generally improves stability.« less

Performance of a MICROMEGAS-based TPC in a high-energy neutron beam

NASA Astrophysics Data System (ADS)

Snyder, L.; Manning, B.; Bowden, N. S.; Bundgaard, J.; Casperson, R. J.; Cebra, D. A.; Classen, T.; Duke, D. L.; Gearhart, J.; Greife, U.; Hagmann, C.; Heffner, M.; Hensle, D.; Higgins, D.; Isenhower, D.; King, J.; Klay, J. L.; Geppert-Kleinrath, V.; Loveland, W.; Magee, J. A.; Mendenhall, M. P.; Sangiorgio, S.; Seilhan, B.; Schmitt, K. T.; Tovesson, F.; Towell, R. S.; Walsh, N.; Watson, S.; Yao, L.; Younes, W.

2018-02-01

The MICROMEGAS (MICRO-MEsh GAseous Structure) charge amplification structure has found wide use in many detection applications, especially as a gain stage for the charge readout of Time Projection Chambers (TPCs). Here we report on the behavior of a MICROMEGAS TPC when operated in a high-energy (up to 800 MeV) neutron beam. It is found that neutron-induced reactions can cause discharges in some drift gas mixtures that are stable in the absence of the neutron beam. The discharges result from recoil ions close to the MICROMEGAS that deposit high specific ionization density and have a limited diffusion time. For a binary drift gas, increasing the percentage of the molecular component (quench gas) relative to the noble component and operating at lower pressures generally improves stability.

76 FR 19724 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-08

... B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R Variant F Airplanes (Collectively... F4-605R and F4-622R airplanes, and Model A300 C4-605R Variant F airplanes; and Model A310-203, -204...

50 CFR 600.750 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Definitions. 600.750 Section 600.750..., DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Fishery Negotiation Panels § 600.750 Definitions... concurrence; or (2) agrees upon another specified definition. Fishery negotiation panel (FNP) means an...

50 CFR 600.750 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Definitions. 600.750 Section 600.750..., DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Fishery Negotiation Panels § 600.750 Definitions... concurrence; or (2) agrees upon another specified definition. Fishery negotiation panel (FNP) means an...

9 CFR 592.600 - General.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false General. 592.600 Section 592.600 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION VOLUNTARY INSPECTION OF EGG PRODUCTS Sanitary and Processing Requirements § 592.600 General...

50 CFR 600.505 - Prohibitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Prohibitions. 600.505 Section 600.505 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.505 Prohibitions. (a) It is...

34 CFR 600.52 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false Definitions. 600.52 Section 600.52 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION...) Programs § 600.52 Definitions. The following definitions apply to this subpart E: Foreign graduate medical...

Neutron fluence and energy reconstruction with the IRSN recoil detector μ-TPC at 27 keV, 144 keV and 565 keV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maire, D.; Lebreton, L.; Richer, J.P.

2015-07-01

The French Institute for Radioprotection and Nuclear Safety (IRSN), associated to the French Metrology Institute (LNE), is developing a time projection chamber using a Micromegas anode: μ-TPC. This work is carried out in collaboration with the Laboratory of Subatomic Physics and Cosmology (LPSC). The aim is to characterize with a primary procedure the energy distribution of neutron fluence in the energy range 8 keV - 1 MeV. The time projection chambers are gaseous detectors, which are able to measure charged particles energy and to reconstruct their track if a pixelated anode is used. In our case, the gas is usedmore » as a (n, p) converter in order to detect neutrons down to few keV. Coming from elastic collisions with neutrons, recoil protons lose a part of their kinetic energy by ionizing the gas. The ionization electrons are drifted toward a pixelated anode (2D projection), read at 50 MHz by a self-triggered electronic system to obtain the third track dimension. The neutron energy is reconstructed event by event thanks to proton scattering angle and proton energy measurements. The scattering angle is deduced from the 3D track. The proton energy is obtained by charge collection measurements, knowing the ionization quenching factor (i.e. the part of proton kinetic energy lost by ionizing the gas). The fluence is calculated thanks to the detected events number and the simulated detector response. The μ-TPC is a new reliable detector which enables to measure energy distribution of the neutron fluence without deconvolution or neutron calibration contrary to usual gaseous counters. The μ-TPC is still being developed and measurements have been carried out at the AMANDE facility, with neutrons energies going from 8 keV to 565 keV. After the context and the μ-TPC working principle presentation, measurements of the neutron energy and fluence at 27.2 keV, 144 keV and 565 keV are shown and compared to the complete detector simulation. This work shows the first direct

24 CFR 598.600 - Applicability.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 3 2012-04-01 2012-04-01 false Applicability. 598.600 Section 598.600 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... Grants § 598.600 Applicability. This subpart applies to a project or activity proposed by an Empowerment...

24 CFR 598.600 - Applicability.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 3 2014-04-01 2013-04-01 true Applicability. 598.600 Section 598.600 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... Grants § 598.600 Applicability. This subpart applies to a project or activity proposed by an Empowerment...

24 CFR 598.600 - Applicability.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 3 2013-04-01 2013-04-01 false Applicability. 598.600 Section 598.600 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... Grants § 598.600 Applicability. This subpart applies to a project or activity proposed by an Empowerment...

7 CFR 25.600 - Purpose.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 1 2012-01-01 2012-01-01 false Purpose. 25.600 Section 25.600 Agriculture Office of the Secretary of Agriculture RURAL EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES Round II and Round IIS Grants § 25.600 Purpose. This subpart outlines USDA policies and authorizations and contains procedures...

7 CFR 25.600 - Purpose.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 1 2013-01-01 2013-01-01 false Purpose. 25.600 Section 25.600 Agriculture Office of the Secretary of Agriculture RURAL EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES Round II and Round IIS Grants § 25.600 Purpose. This subpart outlines USDA policies and authorizations and contains procedures...

7 CFR 25.600 - Purpose.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 1 2014-01-01 2014-01-01 false Purpose. 25.600 Section 25.600 Agriculture Office of the Secretary of Agriculture RURAL EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES Round II and Round IIS Grants § 25.600 Purpose. This subpart outlines USDA policies and authorizations and contains procedures...

7 CFR 25.600 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false Purpose. 25.600 Section 25.600 Agriculture Office of the Secretary of Agriculture RURAL EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES Round II and Round IIS Grants § 25.600 Purpose. This subpart outlines USDA policies and authorizations and contains procedures...

28 CFR 600.5 - Staff.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Staff. 600.5 Section 600.5 Judicial Administration OFFICES OF INDEPENDENT COUNSEL, DEPARTMENT OF JUSTICE GENERAL POWERS OF SPECIAL COUNSEL § 600.5 Staff. A Special Counsel may request the assignment of appropriate Department employees to assist the...

28 CFR 600.5 - Staff.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Staff. 600.5 Section 600.5 Judicial Administration OFFICES OF INDEPENDENT COUNSEL, DEPARTMENT OF JUSTICE GENERAL POWERS OF SPECIAL COUNSEL § 600.5 Staff. A Special Counsel may request the assignment of appropriate Department employees to assist the...

28 CFR 600.5 - Staff.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Staff. 600.5 Section 600.5 Judicial Administration OFFICES OF INDEPENDENT COUNSEL, DEPARTMENT OF JUSTICE GENERAL POWERS OF SPECIAL COUNSEL § 600.5 Staff. A Special Counsel may request the assignment of appropriate Department employees to assist the...

28 CFR 600.5 - Staff.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Staff. 600.5 Section 600.5 Judicial Administration OFFICES OF INDEPENDENT COUNSEL, DEPARTMENT OF JUSTICE GENERAL POWERS OF SPECIAL COUNSEL § 600.5 Staff. A Special Counsel may request the assignment of appropriate Department employees to assist the...

28 CFR 600.5 - Staff.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Staff. 600.5 Section 600.5 Judicial Administration OFFICES OF INDEPENDENT COUNSEL, DEPARTMENT OF JUSTICE GENERAL POWERS OF SPECIAL COUNSEL § 600.5 Staff. A Special Counsel may request the assignment of appropriate Department employees to assist the...

7 CFR 25.600 - Purpose.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 1 2011-01-01 2011-01-01 false Purpose. 25.600 Section 25.600 Agriculture Office of the Secretary of Agriculture RURAL EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES Round II and Round IIS Grants § 25.600 Purpose. This subpart outlines USDA policies and authorizations and contains procedures...

76 FR 441 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-05

... Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R...-622, B4-605R, B4-622R, F4-605R, F4-622R, and C4-605R Variant F airplanes, certificated in any category...

21 CFR 600.90 - Waivers.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Waivers. 600.90 Section 600.90 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL PRODUCTS: GENERAL Reporting of Adverse Experiences § 600.90 Waivers. (a) A licensed manufacturer may ask...

10 CFR 600.143 - Competition.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Competition. 600.143 Section 600.143 Energy DEPARTMENT OF... Nonprofit Organizations Post-Award Requirements § 600.143 Competition. All procurement transactions shall be conducted in a manner to provide, to the maximum extent practical, open and free competition. The recipient...

75 FR 76926 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-10

... Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R... airplanes; Model A300 B4-605R and B4-622R airplanes; Model A300 F4-605R and F4-622R airplanes; Model A300 C4...

75 FR 27956 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-19

... B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R Variant F Airplanes (Collectively...-203, and B4-203 airplanes; Model A300 B4-601, B4- 603, B4-620, B4-622, B4-605R, B4-622R, F4-605R, F4...

10 CFR 600.316 - Audits.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Audits. 600.316 Section 600.316 Energy DEPARTMENT OF... Grants and Cooperative Agreements With For-Profit Organizations Post-Award Requirements § 600.316 Audits. (a) Any recipient that expends $500,000 or more in a year under Federal awards must have an audit...

9 CFR 592.600 - General.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false General. 592.600 Section 592.600 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION VOLUNTARY INSPECTION OF EGG PRODUCTS Sanitary and Processing Requirements § 592.600 General. Except as otherwise approved by the...

9 CFR 592.600 - General.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false General. 592.600 Section 592.600 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION VOLUNTARY INSPECTION OF EGG PRODUCTS Sanitary and Processing Requirements § 592.600 General. Except as otherwise approved by the...

9 CFR 592.600 - General.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false General. 592.600 Section 592.600 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION VOLUNTARY INSPECTION OF EGG PRODUCTS Sanitary and Processing Requirements § 592.600 General. Except as otherwise approved by the...

9 CFR 592.600 - General.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false General. 592.600 Section 592.600 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION VOLUNTARY INSPECTION OF EGG PRODUCTS Sanitary and Processing Requirements § 592.600 General. Except as otherwise approved by the...

21 CFR 600.12 - Records.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Records. 600.12 Section 600.12 Food and Drugs FOOD... PRODUCTS: GENERAL Establishment Standards § 600.12 Records. (a) Maintenance of records. Records shall be... be traced by an inspector. Such records shall be legible and indelible, shall identify the person...

21 CFR 600.12 - Records.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 7 2012-04-01 2012-04-01 false Records. 600.12 Section 600.12 Food and Drugs FOOD... PRODUCTS: GENERAL Establishment Standards § 600.12 Records. (a) Maintenance of records. Records shall be... be traced by an inspector. Such records shall be legible and indelible, shall identify the person...

21 CFR 600.12 - Records.

Code of Federal Regulations, 2010 CFR

2010-04-01

... product upon notification by the Director, Center for Biologics Evaluation and Research or the Director... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Records. 600.12 Section 600.12 Food and Drugs FOOD... PRODUCTS: GENERAL Establishment Standards § 600.12 Records. (a) Maintenance of records. Records shall be...

21 CFR 600.12 - Records.

Code of Federal Regulations, 2011 CFR

2011-04-01

... product upon notification by the Director, Center for Biologics Evaluation and Research or the Director... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Records. 600.12 Section 600.12 Food and Drugs FOOD... PRODUCTS: GENERAL Establishment Standards § 600.12 Records. (a) Maintenance of records. Records shall be...

Integrated Research on the Development of Global Climate Risk Management Strategies - Framework and Initial Results of the Research Project ICA-RUS

NASA Astrophysics Data System (ADS)

Emori, Seita; Takahashi, Kiyoshi; Yamagata, Yoshiki; Oki, Taikan; Mori, Shunsuke; Fujigaki, Yuko

2013-04-01

With the aim of proposing strategies of global climate risk management, we have launched a five-year research project called ICA-RUS (Integrated Climate Assessment - Risks, Uncertainties and Society). In this project with the phrase "risk management" in its title, we aspire for a comprehensive assessment of climate change risks, explicit consideration of uncertainties, utilization of best available information, and consideration of every possible conditions and options. We also regard the problem as one of decision-making at the human level, which involves social value judgments and adapts to future changes in circumstances. The ICA-RUS project consists of the following five themes: 1) Synthesis of global climate risk management strategies, 2) Optimization of land, water and ecosystem uses for climate risk management, 3) Identification and analysis of critical climate risks, 4) Evaluation of climate risk management options under technological, social and economic uncertainties and 5) Interactions between scientific and social rationalities in climate risk management (see also: http://www.nies.go.jp/ica-rus/en/). For the integration of quantitative knowledge of climate change risks and responses, we apply a tool named AIM/Impact [Policy], which consists of an energy-economic model, a simplified climate model and impact projection modules. At the same time, in order to make use of qualitative knowledge as well, we hold monthly project meetings for the discussion of risk management strategies and publish annual reports based on the quantitative and qualitative information. To enhance the comprehensiveness of the analyses, we maintain an inventory of risks and risk management options. The inventory is revised iteratively through interactive meetings with stakeholders such as policymakers, government officials and industrial representatives.

Analysis Strategy and Selection Procedure for νμ Charged Current Inclusive Interactions using the ^0 Detector (P0D) and the Time Projection Chambers of the T2K Experiment

NASA Astrophysics Data System (ADS)

Reinherz-Aronis, Erez; Clifton, Alex; Das, Raj; Toki, Walter; Johnson, Robert; Marino, Alysia; Yuan, Tianlu

2013-04-01

νμ Charge-Current events are produced and collected by the Near Detectors (ND280) in the Tokai to Kamioka (T2K) experiment. This talk focuses on those interactions that are created in the Pi-Zero detector (PøD) and whose momentum is measured by the Time Projection Chambers (TPC). The description of the analysis event selection is presented which includes Data-Quality cuts, Beam Quality parameters, and Fiducial Volume boundaries which are applied on the beginning of the PøD track. In addition the matching procedure of a TPC track to a PøD track and the optimization of this procedure in presented.

Design of the cryogenic systems for the Near and Far LAr-TPC detectors of the Short-Baseline Neutrino program (SBN) at Fermilab

DOE Office of Scientific and Technical Information (OSTI.GOV)

Geynisman, M.; Bremer, J.; Chalifour, M.

The Short-Baseline Neutrino (SBN) physics program at Fermilab and Neutrino Platform (NP) at CERN are part of the international Neutrino Program leading to the development of Long-Baseline Neutrino Facility/Deep Underground Neutrino Experiment (LBNF/DUNE) science project. The SBN program consisting of three Liquid Argon Time Projection Chamber (LAr-TPC) detectors positioned along the Booster Neutrino Beam (BNB) at Fermilab includes an existing detector known as MicroBooNE (170-ton LAr-TPC) plus two new experiments known as SBN’s Near Detector (SBND, ~260 tons) and SBN’s Far Detector (SBN-FD, ~760 tons). All three detectors have distinctly different design of their cryostats thus defining specific requirements formore » the cryogenic systems. Fermilab has already built two new facilities to house SBND and SBN-FD detectors. The cryogenic systems for these detectors are in various stages of design and construction with CERN and Fermilab being responsible for delivery of specific sub-systems. This contribution presents specific design requirements and typical implementation solutions for each sub-system of the SBND and SBN-FD cryogenic systems.« less

Design of the cryogenic systems for the Near and Far LAr-TPC detectors of the Short-Baseline Neutrino program (SBN) at Fermilab

NASA Astrophysics Data System (ADS)

Geynisman, M.; Bremer, J.; Chalifour, M.; Delaney, M.; Dinnon, M.; Doubnik, R.; Hentschel, S.; Kim, M. J.; Montanari, C.; Montanari, D.; Nichols, T.; Norris, B.; Sarychev, M.; Schwartz, F.; Tillman, J.; Zuckerbrot, M.

2017-12-01

The Short-Baseline Neutrino (SBN) physics program at Fermilab and Neutrino Platform (NP) at CERN are part of the international Neutrino Program leading to the development of Long-Baseline Neutrino Facility/Deep Underground Neutrino Experiment (LBNF/DUNE) science project. The SBN program consisting of three Liquid Argon Time Projection Chamber (LAr-TPC) detectors positioned along the Booster Neutrino Beam (BNB) at Fermilab includes an existing detector known as MicroBooNE (170-ton LAr-TPC) plus two new experiments known as SBN’s Near Detector (SBND, ∼260 tons) and SBN’s Far Detector (SBN-FD, ∼760 tons). All three detectors have distinctly different design of their cryostats thus defining specific requirements for the cryogenic systems. Fermilab has already built two new facilities to house SBND and SBN-FD detectors. The cryogenic systems for these detectors are in various stages of design and construction with CERN and Fermilab being responsible for delivery of specific sub-systems. This contribution presents specific design requirements and typical implementation solutions for each sub-system of the SBND and SBN-FD cryogenic systems.

Comment on “Modeling of opposition effects with ensembles of clusters: Interplay of various scattering mechanisms” by Elena V. Petrova, Victor P. Tishkovets, Klaus Jockers, 2007 [Icarus 188, 233 245

NASA Astrophysics Data System (ADS)

Shkuratov, Yuriy G.; Zubko, Evgenij S.

2008-04-01

We show that the mechanism called "near-field effect" [e.g., Petrova, E.V., Tishkovets, V.P., Jockers, K., 2007. Icarus 188, 233-245], which is used to explain wide-phase-angle negative polarization branch observed for planetary regoliths and cometary comas, is not realistic as it contradicts laboratory experiments and results of modeling with discrete dipole approximation calculations.

10 CFR 600.152 - Financial reporting.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Financial reporting. 600.152 Section 600.152 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES Uniform Administrative... Nonprofit Organizations Post-Award Requirements § 600.152 Financial reporting. (a) The following forms or...

10 CFR 603.600 - Administrative matters.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Administrative matters. 603.600 Section 603.600 Energy... Affecting Participants' Financial, Property, and Purchasing Systems § 603.600 Administrative matters. This subpart addresses “systemic” administrative matters that place requirements on the operation of a...

10 CFR 603.600 - Administrative matters.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Administrative matters. 603.600 Section 603.600 Energy... Affecting Participants' Financial, Property, and Purchasing Systems § 603.600 Administrative matters. This subpart addresses “systemic” administrative matters that place requirements on the operation of a...

10 CFR 603.600 - Administrative matters.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Administrative matters. 603.600 Section 603.600 Energy... Affecting Participants' Financial, Property, and Purchasing Systems § 603.600 Administrative matters. This subpart addresses “systemic” administrative matters that place requirements on the operation of a...

10 CFR 603.600 - Administrative matters.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Administrative matters. 603.600 Section 603.600 Energy... Affecting Participants' Financial, Property, and Purchasing Systems § 603.600 Administrative matters. This subpart addresses “systemic” administrative matters that place requirements on the operation of a...

10 CFR 603.600 - Administrative matters.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Administrative matters. 603.600 Section 603.600 Energy... Affecting Participants' Financial, Property, and Purchasing Systems § 603.600 Administrative matters. This subpart addresses “systemic” administrative matters that place requirements on the operation of a...

50 CFR 600.110 - Intercouncil fisheries.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Intercouncil fisheries. 600.110 Section 600.110 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Regional Fishery Management Councils § 600...

50 CFR 600.509 - Prohibited species.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Prohibited species. 600.509 Section 600.509 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.509 Prohibited...

50 CFR 600.110 - Intercouncil fisheries.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Intercouncil fisheries. 600.110 Section 600.110 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Regional Fishery Management Councils § 600...

50 CFR 600.513 - Recreational fishing.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Recreational fishing. 600.513 Section 600.513 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.513 Recreational...

50 CFR 600.508 - Fishing operations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Fishing operations. 600.508 Section 600.508 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.508 Fishing...

50 CFR 600.235 - Financial disclosure.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Financial disclosure. 600.235 Section 600.235 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.235 Financial...

50 CFR 600.135 - Meeting procedures.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Meeting procedures. 600.135 Section 600.135 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Regional Fishery Management Councils § 600...

50 CFR 600.135 - Meeting procedures.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Meeting procedures. 600.135 Section 600.135 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Regional Fishery Management Councils § 600...

10 CFR 600.141 - Recipient responsibilities.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Nonprofit Organizations Post-Award Requirements § 600.141 Recipient responsibilities. The standards... contract(s). The recipient is the responsible authority, without recourse to DOE regarding the settlement... 10 Energy 4 2012-01-01 2012-01-01 false Recipient responsibilities. 600.141 Section 600.141 Energy...

10 CFR 600.141 - Recipient responsibilities.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Nonprofit Organizations Post-Award Requirements § 600.141 Recipient responsibilities. The standards... contract(s). The recipient is the responsible authority, without recourse to DOE regarding the settlement... 10 Energy 4 2011-01-01 2011-01-01 false Recipient responsibilities. 600.141 Section 600.141 Energy...

10 CFR 600.141 - Recipient responsibilities.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Nonprofit Organizations Post-Award Requirements § 600.141 Recipient responsibilities. The standards... contract(s). The recipient is the responsible authority, without recourse to DOE regarding the settlement... 10 Energy 4 2013-01-01 2013-01-01 false Recipient responsibilities. 600.141 Section 600.141 Energy...

10 CFR 600.141 - Recipient responsibilities.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Nonprofit Organizations Post-Award Requirements § 600.141 Recipient responsibilities. The standards... contract(s). The recipient is the responsible authority, without recourse to DOE regarding the settlement... 10 Energy 4 2014-01-01 2014-01-01 false Recipient responsibilities. 600.141 Section 600.141 Energy...

40 CFR 600.001 - General applicability.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 31 2013-07-01 2013-07-01 false General applicability. 600.001 Section 600.001 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES General Provisions § 600.001 General...

40 CFR 600.001 - General applicability.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 31 2012-07-01 2012-07-01 false General applicability. 600.001 Section 600.001 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES General Provisions § 600.001 General...

40 CFR 600.301 - Labeling requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 31 2013-07-01 2013-07-01 false Labeling requirements. 600.301 Section 600.301 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Labeling § 600.301 Labeling...

40 CFR 600.301 - Labeling requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Labeling requirements. 600.301 Section 600.301 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Labeling § 600.301 Labeling...

40 CFR 600.301 - Labeling requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Labeling requirements. 600.301 Section 600.301 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Labeling § 600.301 Labeling...

40 CFR 600.001 - General applicability.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 30 2014-07-01 2014-07-01 false General applicability. 600.001 Section 600.001 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES General Provisions § 600.001 General...

10 CFR 600.152 - Financial reporting.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Financial reporting. 600.152 Section 600.152 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES Uniform Administrative... Nonprofit Organizations Post-Award Requirements § 600.152 Financial reporting. (a) The following forms or...

10 CFR 600.132 - Real property.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Real property. 600.132 Section 600.132 Energy DEPARTMENT... Nonprofit Organizations Post-Award Requirements § 600.132 Real property. Unless otherwise provided by statute or program regulations, the requirements concerning the use and disposition of real property...

10 CFR 600.132 - Real property.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Real property. 600.132 Section 600.132 Energy DEPARTMENT... Nonprofit Organizations Post-Award Requirements § 600.132 Real property. Unless otherwise provided by statute or program regulations, the requirements concerning the use and disposition of real property...

10 CFR 600.132 - Real property.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Real property. 600.132 Section 600.132 Energy DEPARTMENT... Nonprofit Organizations Post-Award Requirements § 600.132 Real property. Unless otherwise provided by statute or program regulations, the requirements concerning the use and disposition of real property...

10 CFR 600.132 - Real property.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Real property. 600.132 Section 600.132 Energy DEPARTMENT... Nonprofit Organizations Post-Award Requirements § 600.132 Real property. Unless otherwise provided by statute or program regulations, the requirements concerning the use and disposition of real property...

14 CFR 1259.600 - Panel description.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Panel description. 1259.600 Section 1259.600 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NATIONAL SPACE GRANT COLLEGE AND FELLOWSHIP PROGRAM Space Grant Review Panel § 1259.600 Panel description. An independent committee...

50 CFR 600.513 - Recreational fishing.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Recreational fishing. 600.513 Section 600... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.513 Recreational fishing. (a) Foreign vessels conducting recreational fishing must comply only with this section, and...

50 CFR 600.513 - Recreational fishing.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Recreational fishing. 600.513 Section 600... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.513 Recreational fishing. (a) Foreign vessels conducting recreational fishing must comply only with this section, and...

50 CFR 600.513 - Recreational fishing.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Recreational fishing. 600.513 Section 600... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.513 Recreational fishing. (a) Foreign vessels conducting recreational fishing must comply only with this section, and...

50 CFR 600.513 - Recreational fishing.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Recreational fishing. 600.513 Section 600... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.513 Recreational fishing. (a) Foreign vessels conducting recreational fishing must comply only with this section, and...

50 CFR 600.240 - Security assurances.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Security assurances. 600.240 Section 600... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.240 Security assurances. (a) DOC Office of Security will issue security assurances to Council members following completion...

50 CFR 600.240 - Security assurances.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Security assurances. 600.240 Section 600... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.240 Security assurances. (a) DOC Office of Security will issue security assurances to Council members following completion...

50 CFR 600.240 - Security assurances.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Security assurances. 600.240 Section 600... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.240 Security assurances. (a) DOC Office of Security will issue security assurances to Council members following completion...

10 CFR 600.244 - Termination for convenience.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Termination for convenience. 600.244 Section 600.244 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES Uniform... Requirements § 600.244 Termination for convenience. Except as provided in § 600.443 awards may be terminated in...

10 CFR 600.148 - Contract provisions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Contract provisions. 600.148 Section 600.148 Energy... Nonprofit Organizations Post-Award Requirements § 600.148 Contract provisions. The recipient shall include... contracts. The following provisions shall also be applied to subcontracts. (a) Contracts in excess of the...

14 CFR 1259.600 - Panel description.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Panel description. 1259.600 Section 1259.600 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NATIONAL SPACE GRANT COLLEGE AND FELLOWSHIP PROGRAM Space Grant Review Panel § 1259.600 Panel description. An independent committee, the Space...

10 CFR 600.31 - Research misconduct.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Research misconduct. 600.31 Section 600.31 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES General § 600.31 Research misconduct. (a) A recipient is responsible for maintaining the integrity of research of any kind under an...

10 CFR 600.31 - Research misconduct.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Research misconduct. 600.31 Section 600.31 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES General § 600.31 Research misconduct. (a) A recipient is responsible for maintaining the integrity of research of any kind under an...

10 CFR 600.31 - Research misconduct.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Research misconduct. 600.31 Section 600.31 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES General § 600.31 Research misconduct. (a) A recipient is responsible for maintaining the integrity of research of any kind under an...

10 CFR 600.31 - Research misconduct.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Research misconduct. 600.31 Section 600.31 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES General § 600.31 Research misconduct. (a) A recipient is responsible for maintaining the integrity of research of any kind under an...

50 CFR 600.508 - Fishing operations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Fishing operations. 600.508 Section 600... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.508 Fishing.... fishing vessels. These joint venture operations with U.S. fishing vessels may be conducted throughout the...

50 CFR 600.508 - Fishing operations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Fishing operations. 600.508 Section 600... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.508 Fishing.... fishing vessels. These joint venture operations with U.S. fishing vessels may be conducted throughout the...

50 CFR 600.508 - Fishing operations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Fishing operations. 600.508 Section 600... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.508 Fishing.... fishing vessels. These joint venture operations with U.S. fishing vessels may be conducted throughout the...

50 CFR 600.508 - Fishing operations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Fishing operations. 600.508 Section 600... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.508 Fishing.... fishing vessels. These joint venture operations with U.S. fishing vessels may be conducted throughout the...

14 CFR 1212.600 - General policy.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true General policy. 1212.600 Section 1212.600 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PRIVACY ACT-NASA REGULATIONS Instructions for NASA Employees § 1212.600 General policy. In compliance with the Privacy Act and in accordance...

14 CFR 1212.600 - General policy.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false General policy. 1212.600 Section 1212.600 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PRIVACY ACT-NASA REGULATIONS Instructions for NASA Employees § 1212.600 General policy. In compliance with the Privacy Act and in accordance...

10 CFR 600.131 - Insurance coverage.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Insurance coverage. 600.131 Section 600.131 Energy... Nonprofit Organizations Post-Award Requirements § 600.131 Insurance coverage. Recipients shall, at a minimum, provide the equivalent insurance coverage for real property and equipment acquired with DOE funds as...

50 CFR 600.420 - Control system.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Control system. 600.420 Section 600.420..., DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Confidentiality of Statistics § 600.420 Control system. (a) The Assistant Administrator maintains a control system to protect the identity of submitters of...

50 CFR 600.420 - Control system.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Control system. 600.420 Section 600.420..., DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Confidentiality of Statistics § 600.420 Control system. (a) The Assistant Administrator maintains a control system to protect the identity of submitters of...

50 CFR 600.420 - Control system.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Control system. 600.420 Section 600.420..., DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Confidentiality of Statistics § 600.420 Control system. (a) The Assistant Administrator maintains a control system to protect the identity of submitters of...

50 CFR 600.420 - Control system.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Control system. 600.420 Section 600.420..., DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Confidentiality of Statistics § 600.420 Control system. (a) The Assistant Administrator maintains a control system to protect the identity of submitters of...

50 CFR 600.420 - Control system.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Control system. 600.420 Section 600.420..., DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Confidentiality of Statistics § 600.420 Control system. (a) The Assistant Administrator maintains a control system to protect the identity of submitters of...

16 CFR 600.2 - Legal effect.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Legal effect. 600.2 Section 600.2 Commercial Practices FEDERAL TRADE COMMISSION THE FAIR CREDIT REPORTING ACT STATEMENTS OF GENERAL POLICY OR INTERPRETATIONS § 600.2 Legal effect. (a) The interpretations in the Commentary are not trade regulation rules or...

16 CFR 600.2 - Legal effect.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Legal effect. 600.2 Section 600.2 Commercial Practices FEDERAL TRADE COMMISSION THE FAIR CREDIT REPORTING ACT STATEMENTS OF GENERAL POLICY OR INTERPRETATIONS § 600.2 Legal effect. (a) The interpretations in the Commentary are not trade regulation rules or...

7 CFR 600.5 - Area offices.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false Area offices. 600.5 Section 600.5 Agriculture... AGRICULTURE GENERAL ORGANIZATION § 600.5 Area offices. Each area office is under the direction and supervision... for NRCS activities in the geographical area served by the area office. Usually the geographical area...

7 CFR 600.6 - Field offices.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false Field offices. 600.6 Section 600.6 Agriculture... AGRICULTURE GENERAL ORGANIZATION § 600.6 Field offices. Each field office is under the direction and... served by the field office. Usually the geographical area of a field office includes one or more...

21 CFR 600.81 - Distribution reports.

Code of Federal Regulations, 2010 CFR

2010-04-01

... and Research (see mailing addresses in § 600.2), information about the quantity of the product... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Distribution reports. 600.81 Section 600.81 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS...

21 CFR 600.81 - Distribution reports.

Code of Federal Regulations, 2011 CFR

2011-04-01

... and Research (see mailing addresses in § 600.2), information about the quantity of the product... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Distribution reports. 600.81 Section 600.81 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS...

10 CFR 600.353 - Disputes and appeals.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Disputes and appeals. 600.353 Section 600.353 Energy... Requirements for Grants and Cooperative Agreements With For-Profit Organizations Post-Award Requirements § 600.353 Disputes and appeals. Consistent with 10 CFR 600.22 and part 1024, recipients have the right to...

10 CFR 600.124 - Program income.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Program income. 600.124 Section 600.124 Energy DEPARTMENT... Nonprofit Organizations Post-Award Requirements § 600.124 Program income. (a) The standards set forth in this section shall be used to account for program income related to projects financed in whole or in...

50 CFR 600.625 - Secretary's decision.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Secretary's decision. 600.625 Section 600... Section 306(b) § 600.625 Secretary's decision. (a) The Secretary will, on the basis of the hearing, record... for Federal preemption are determined to exist, the Secretary will notify in writing the Attorney...

50 CFR 600.625 - Secretary's decision.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Secretary's decision. 600.625 Section 600... Section 306(b) § 600.625 Secretary's decision. (a) The Secretary will, on the basis of the hearing, record... for Federal preemption are determined to exist, the Secretary will notify in writing the Attorney...

50 CFR 600.625 - Secretary's decision.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Secretary's decision. 600.625 Section 600... Section 306(b) § 600.625 Secretary's decision. (a) The Secretary will, on the basis of the hearing, record... for Federal preemption are determined to exist, the Secretary will notify in writing the Attorney...

7 CFR 600.4 - State offices.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false State offices. 600.4 Section 600.4 Agriculture... AGRICULTURE GENERAL ORGANIZATION § 600.4 State offices. Each office is under the direction and supervision of... Pacific Basin Area Office, under the direction and supervision of a director, serves the U.S. Trust...

46 CFR 181.600 - Fire axe.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Fire axe. 181.600 Section 181.600 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) FIRE PROTECTION EQUIPMENT Additional Equipment § 181.600 Fire axe. A vessel of more than 19.8 meters (65 feet) in length...

Investigating 3-body Decays of Cluster States with the PAT-TPC

NASA Astrophysics Data System (ADS)

Carpenter, Lisa; Ayyad Limonge, Y.; Bazin, D.; Beceiro-Novo, S.; Bradt, J.; Cortesi, M.; Mittig, W.; Ahn, T.; Kolata, J. J.; Meisel, Z.; Bechetti, F. D.; Fritsch, A.; Howard, A.

2016-03-01

Recent model calculations with most advanced methods for cluster states have shown the need of experimental data to probe the structure of light exotic nuclei, including those with α-clustering, such as 14C. The Prototype Active Target Time Projection Chamber (PAT-TPC) allows us to investigate these types of structures, giving access to the full excitation function with a single beam energy. This type of experiment measures resonances in 14C that can be compared to the models. With an improved Micromegas pad plane with a circular backgammon design we are able to investigate 3-body decays in addition to 2-body scattering. The measurements were carried out by resonant alpha-scattering on 10Be beam delivered by the TwinSol facility at the University of Notre Dame. We also observed the 3-body decay of the Hoyle State in 12C from a 12N or 12B beam with the same device. Preliminary results will be presented. This work is supported by the National Science Foundation.

Hypersonic Wind Tunnel Nozzle Survivability for T&E

DTIC Science & Technology

2007-03-01

Room-Temperature Compression Tests ..............................................................43 10. Strength of Hot-Rolled Inconel 600 (Ni-16Cr...6Fe, wt %) ...................................................45 11. Physical Properties of Inconel 600...Table 10. Strength of Hot-Rolled Inconel 600 (Ni-16Cr-6Fe, wt%) T, °C 0.2% Yield Stress (MPa) Ultimate Tensile Stress (MPa) 20 250 590 400 185 560

46 CFR 118.600 - Fire axe.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Fire axe. 118.600 Section 118.600 Shipping COAST GUARD... OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS FIRE PROTECTION EQUIPMENT Additional Equipment § 118.600 Fire axe. A vessel of more than 19.8 meters (65 feet) in length must have at least one fire axe...

Relationship between tumor biomarkers and efficacy in TH3RESA, a phase III study of trastuzumab emtansine (T-DM1) vs. treatment of physician's choice in previously treated HER2-positive advanced breast cancer.

PubMed

Kim, Sung-Bae; Wildiers, Hans; Krop, Ian E; Smitt, Melanie; Yu, Ron; Lysbet de Haas, Sanne; Gonzalez-Martin, Antonio

2016-11-15

In the phase III TH3RESA study (NCT01419197), 602 patients with HER2-positive advanced breast cancer who received prior taxane therapy and ≥2 HER2-directed regimens, including trastuzumab and lapatinib (advanced setting), were randomized to trastuzumab emtansine (T-DM1) or treatment of physician's choice (TPC). A statistically significant progression-free survival (PFS) benefit favoring T-DM1 was demonstrated. Here, we examine the relationship between HER2-related biomarkers and PFS in an exploratory analysis. Biomarkers assessed included HER2 (n = 505) and HER3 (n = 505) mRNA expression, PIK3CA mutation status (n = 410) and PTEN protein expression (n = 358). For biomarkers with continuous data (HER2, HER3, PTEN), subgroups were defined using median values (>median and ≤median). For all biomarker subgroups, median PFS was longer with T-DM1 vs. TPC. The PFS benefit favoring T-DM1 vs. TPC was numerically greater in the HER2 mRNA >median subgroup (7.2 vs. 3.4 months; unstratified hazard ratio [HR], 0.40; 95% CI, 0.28-0.59; p < 0.0001) vs. ≤median subgroup (5.5 vs. 3.9 months; HR, 0.68; 95% CI, 0.49-0.92; p = 0.0131). The PFS benefit with T-DM1 was similar among HER3, PIK3CA and PTEN subgroups. Consistent with other reports, benefit was seen with T-DM1 regardless of PIK3CA mutation status. In a multivariate analysis including an interaction term (treatment group by log2-transformed HER2 mRNA), patients with higher HER2 mRNA levels benefited more from receiving T-DM1 (HR, 0.84; 95% CI, 0.75-0.94; interaction p value = 0.0027). In summary, T-DM1 prolonged median PFS in all biomarker subgroups analyzed, including activating PIK3CA mutations, with numerically greater benefit in patients with tumors expressing HER2 mRNA >median vs. ≤median. © 2016 UICC.

7 CFR 900.600 - General.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false General. 900.600 Section 900.600 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS Information...

7 CFR 900.600 - General.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 8 2014-01-01 2014-01-01 false General. 900.600 Section 900.600 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS Information...

7 CFR 900.600 - General.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 8 2012-01-01 2012-01-01 false General. 900.600 Section 900.600 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS Information...

7 CFR 900.600 - General.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 8 2013-01-01 2013-01-01 false General. 900.600 Section 900.600 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS Information...

38 CFR 0.600 - General.

Code of Federal Regulations, 2014 CFR

2014-07-01

....600 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS VALUES, STANDARDS OF ETHICAL CONDUCT, AND RELATED RESPONSIBILITIES Core Values and Characteristics of the Department § 0.600 General. This section describes the Core Values and Characteristics that serve as internal guidelines for...

38 CFR 0.600 - General.

Code of Federal Regulations, 2013 CFR

2013-07-01

....600 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS VALUES, STANDARDS OF ETHICAL CONDUCT, AND RELATED RESPONSIBILITIES Core Values and Characteristics of the Department § 0.600 General. This section describes the Core Values and Characteristics that serve as internal guidelines for...

Electron Attenuation Measurement using Cosmic Ray Muons at the MicroBooNE LArTPC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meddage, Varuna

2017-10-01

The MicroBooNE experiment at Fermilab uses liquid argon time projection chamber (LArTPC) technology to study neutrino interactions in argon. A fundamental requirement for LArTPCs is to achieve and maintain a low level of electronegative contaminants in the liquid to minimize the capture of drifting ionization electrons. The attenuation time for the drifting electrons should be long compared to the maximum drift time, so that the signals from particle tracks that generate ionization electrons with long drift paths can be detected efficiently. In this talk we present MicroBooNE measurement of electron attenuation using cosmic ray muons. The result yields a minimummore » electron 1/e lifetime of 18 ms under typical operating conditions, which is long compared to the maximum drift time of 2.3 ms.« less

SAMPA Chip: the New 32 Channels ASIC for the ALICE TPC and MCH Upgrades

NASA Astrophysics Data System (ADS)

Adolfsson, J.; Ayala Pabon, A.; Bregant, M.; Britton, C.; Brulin, G.; Carvalho, D.; Chambert, V.; Chinellato, D.; Espagnon, B.; Hernandez Herrera, H. D.; Ljubicic, T.; Mahmood, S. M.; Mjörnmark, U.; Moraes, D.; Munhoz, M. G.; Noël, G.; Oskarsson, A.; Osterman, L.; Pilyar, A.; Read, K.; Ruette, A.; Russo, P.; Sanches, B. C. S.; Severo, L.; Silvermyr, D.; Suire, C.; Tambave, G. J.; Tun-Lanoë, K. M. M.; van Noije, W.; Velure, A.; Vereschagin, S.; Wanlin, E.; Weber, T. O.; Zaporozhets, S.

2017-04-01

This paper presents the test results of the second prototype of SAMPA, the ASIC designed for the upgrade of read-out front end electronics of the ALICE Time Projection Chamber (TPC) and Muon Chamber (MCH). SAMPA is made in a 130 nm CMOS technology with 1.25 V nominal voltage supply and provides 32 channels, with selectable input polarity, and three possible combinations of shaping time and sensitivity. Each channel consists of a Charge Sensitive Amplifier, a semi-Gaussian shaper and a 10-bit ADC; a Digital Signal Processor provides digital filtering and compression capability. In the second prototype run both full chip and single test blocks were fabricated, allowing block characterization and full system behaviour studies. Experimental results are here presented showing agreement with requirements for both the blocks and the full chip.

50 CFR 600.750 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Definitions. 600.750 Section 600.750 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION.... Consensus means unanimous concurrence among the members on a Fishery Negotiation Panel established under...

7 CFR 1220.600 - Act.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1220.600 Section 1220.600 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS..., Promotion, Research, and Consumer Information Act set forth in title XIX, subtitle E, of the Food...

13 CFR 130.600 - Cooperative agreement. [Reserved

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Cooperative agreement. [Reserved] 130.600 Section 130.600 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS DEVELOPMENT CENTERS § 130.600 Cooperative agreement. [Reserved] ...

13 CFR 130.600 - Cooperative agreement. [Reserved

Code of Federal Regulations, 2011 CFR

2011-01-01

... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Cooperative agreement. [Reserved] 130.600 Section 130.600 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS DEVELOPMENT CENTERS § 130.600 Cooperative agreement. [Reserved] ...

31 CFR 1026.600 - General.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false General. 1026.600 Section 1026.600 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY RULES FOR FUTURES COMMISSION MERCHANTS AND INTRODUCING BROKERS...

31 CFR 1026.600 - General.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false General. 1026.600 Section 1026.600 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY RULES FOR FUTURES COMMISSION MERCHANTS AND INTRODUCING BROKERS...

31 CFR 1026.600 - General.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false General. 1026.600 Section 1026.600 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY RULES FOR FUTURES COMMISSION MERCHANTS AND INTRODUCING BROKERS...

31 CFR 1026.600 - General.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false General. 1026.600 Section 1026.600 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY RULES FOR FUTURES COMMISSION MERCHANTS AND INTRODUCING BROKERS...

31 CFR 1022.600 - General.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false General. 1022.600 Section 1022.600 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY RULES FOR MONEY SERVICES BUSINESSES Special Standards of...

31 CFR 1022.600 - General.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false General. 1022.600 Section 1022.600 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY RULES FOR MONEY SERVICES BUSINESSES Special Standards of...

31 CFR 1022.600 - General.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false General. 1022.600 Section 1022.600 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY RULES FOR MONEY SERVICES BUSINESSES Special Standards of...

31 CFR 1022.600 - General.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false General. 1022.600 Section 1022.600 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY RULES FOR MONEY SERVICES BUSINESSES Special Standards of...

24 CFR 960.600 - Implementation.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Implementation. 960.600 Section 960.600 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT...

9 CFR 319.600 - [Reserved

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false [Reserved] 319.600 Section 319.600 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... CERTIFICATION DEFINITIONS AND STANDARDS OF IDENTITY OR COMPOSITION Meat Snacks, Hors d'Oeuvres, Pizza, and...

9 CFR 319.600 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false [Reserved] 319.600 Section 319.600 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... CERTIFICATION DEFINITIONS AND STANDARDS OF IDENTITY OR COMPOSITION Meat Snacks, Hors d'Oeuvres, Pizza, and...

21 CFR 600.10 - Personnel.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Personnel. 600.10 Section 600.10 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL... manufacturing operations which they perform, the necessary training and experience relating to individual...

24 CFR 570.600 - General.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false General. 570.600 Section 570.600 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT...

13 CFR 120.600 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Definitions. 120.600 Section 120.600 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Secondary Market... listed in FTA's records. (k) SBA's Secondary Market Program Guide is an issuance from SBA which describes...

7 CFR 600.7 - Specialized field offices.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false Specialized field offices. 600.7 Section 600.7..., DEPARTMENT OF AGRICULTURE GENERAL ORGANIZATION § 600.7 Specialized field offices. Other field offices serve... direction and supervision of these offices. ...

MIMAC-He3: MICRO-TPC MATRIX OF CHAMBERS OF 3He

NASA Astrophysics Data System (ADS)

Santos, D.; Guillaudin, O.; Lamy, Th.; Mayet, F.; Moulin, E.

2007-08-01

The project of a micro-TPC matrix of chambers of 3He for direct detection of non-baryonic dark matter is outlined. The privileged properties of 3He are highlighted. The double detection (ionization - projection of tracks) will assure the electron-recoil discrimination. The complementarity of MIMAC-He3 for supersymmetric dark matter search with respect to other experiments is illustrated. The modular character of the detector allows to have different gases to get A-dependence. The pressure degreee of freedom gives the possibility to work at high and low pressure. The low pressure regime gives the possibility to get the directionality of the tracks. The first measurements of ionization at very few keVs for 3He in 4He gas are described.

40 CFR 35.600 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-07-01

... ASSISTANCE Environmental Program Grants for Tribes Water Quality Cooperative Agreements (section 104(b)(3)) § 35.600 Purpose. (a) Purpose of section. Sections 35.600 through 35.604 govern Water Quality... Water Act. These sections do not govern Water Quality Cooperative Agreements under section 104(b)(3) to...

46 CFR 199.600 - General.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false General. 199.600 Section 199.600 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LIFESAVING APPLIANCES AND ARRANGEMENTS LIFESAVING SYSTEMS FOR.... This subpart sets out specific exemptions and alternatives to requirements in subparts A, B, C, D, and...

38 CFR 17.600 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Purpose. 17.600 Section 17.600 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Va Health... Scholarship Program to students receiving education or training in a direct or indirect health-care services...

45 CFR 153.600 - [Reserved

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 1 2013-10-01 2013-10-01 false [Reserved] 153.600 Section 153.600 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS STANDARDS RELATED TO REINSURANCE, RISK CORRIDORS, AND RISK ADJUSTMENT UNDER THE AFFORDABLE CARE ACT Health Insurance Issuer...

45 CFR 153.600 - [Reserved

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 1 2014-10-01 2014-10-01 false [Reserved] 153.600 Section 153.600 Public Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE ACCESS STANDARDS RELATED TO REINSURANCE, RISK CORRIDORS, AND RISK ADJUSTMENT UNDER THE AFFORDABLE CARE ACT Health Insurance Issuer...

45 CFR 153.600 - [Reserved

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 1 2012-10-01 2012-10-01 false [Reserved] 153.600 Section 153.600 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS STANDARDS RELATED TO REINSURANCE, RISK CORRIDORS, AND RISK ADJUSTMENT UNDER THE AFFORDABLE CARE ACT Health Insurance Issuer...

10 CFR 600.230 - Changes.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Changes. 600.230 Section 600.230 Energy DEPARTMENT OF... Changes. (a) General. Grantees and subgrantees are permitted to rebudget within the approved direct cost budget to meet unanticipated requirements and may make limited program changes to the approved project...

50 CFR 600.245 - Council member compensation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Council member compensation. 600.245 Section 600.245 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600...

10 CFR 600.137 - Property trust relationship.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Property trust relationship. 600.137 Section 600.137 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES Uniform..., Hospitals, and Other Nonprofit Organizations Post-Award Requirements § 600.137 Property trust relationship...

35t Prototype Detector for Experiment at Long Base Line Neutrino Facility (ELBNF) Far Detector

NASA Astrophysics Data System (ADS)

Santucci, Gabriel; Elbnf Collaboration

2015-04-01

The 35ton prototype detector is a Liquid Argon Time Projection Chamber (LAr TPC) utilizing a membrane cryostat. It serves as a prototype for testing technology proposed for the ELBNF far detector. The construction of the prototype is an essential part of the ELBNF project due to the large amount of new technologies introduced for the far detector. In early 2014, it was shown that the membrane cryostat technology was able to reach and maintain the required LAr purity and an electron lifetime of 2.5 ms was achieved. The goals for the next phase include the installation of a fully functional TPC using the novel designs for the ELBNF far detector as much as possible. This includes the installation of the cold electronics, scintillation photon detectors and multiple Anode Plane Arrays with wrapped wires. In this talk I will review the status of the 35t prototype detector and describe what has been accomplished during 2014 and early 2015, including the commissioning phase and the early stages of data taking from cosmic-rays.

21 CFR 600.20 - Inspectors.

Code of Federal Regulations, 2013 CFR

2013-04-01

... the Food and Drug Administration having special knowledge of the methods used in the manufacture and... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Inspectors. 600.20 Section 600.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL...

21 CFR 600.20 - Inspectors.

Code of Federal Regulations, 2012 CFR

2012-04-01

... the Food and Drug Administration having special knowledge of the methods used in the manufacture and... 21 Food and Drugs 7 2012-04-01 2012-04-01 false Inspectors. 600.20 Section 600.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL...

21 CFR 600.20 - Inspectors.

Code of Federal Regulations, 2014 CFR

2014-04-01

... the Food and Drug Administration having special knowledge of the methods used in the manufacture and... 21 Food and Drugs 7 2014-04-01 2014-04-01 false Inspectors. 600.20 Section 600.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL...

24 CFR 200.600 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Purpose. 200.600 Section 200.600 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS...

21 CFR 600.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Definitions. 600.3 Section 600.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL... Services to whom the authority involved has been delegated. (c) Commissioner of Food and Drugs means the...

21 CFR 600.3 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 7 2014-04-01 2014-04-01 false Definitions. 600.3 Section 600.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL... Services to whom the authority involved has been delegated. (c) Commissioner of Food and Drugs means the...

21 CFR 600.3 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 7 2012-04-01 2012-04-01 false Definitions. 600.3 Section 600.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL... Services to whom the authority involved has been delegated. (c) Commissioner of Food and Drugs means the...

21 CFR 600.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Definitions. 600.3 Section 600.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL... Services to whom the authority involved has been delegated. (c) Commissioner of Food and Drugs means the...

21 CFR 600.3 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Definitions. 600.3 Section 600.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL... Services to whom the authority involved has been delegated. (c) Commissioner of Food and Drugs means the...

48 CFR 17.600 - Scope of subpart.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Scope of subpart. 17.600 Section 17.600 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Management and Operating Contracts 17.600 Scope of...

48 CFR 511.600 - Scope of subpart.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Scope of subpart. 511.600 Section 511.600 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION COMPETITION AND ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Priorities and Allocations 511.600 Scope of subpart. Pursuant to...

48 CFR 17.600 - Scope of subpart.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Scope of subpart. 17.600 Section 17.600 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Management and Operating Contracts 17.600 Scope of...

48 CFR 511.600 - Scope of subpart.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Scope of subpart. 511.600 Section 511.600 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION COMPETITION AND ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Priorities and Allocations 511.600 Scope of subpart. Pursuant to...

48 CFR 17.600 - Scope of subpart.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Scope of subpart. 17.600 Section 17.600 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Management and Operating Contracts 17.600 Scope of...

48 CFR 17.600 - Scope of subpart.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Scope of subpart. 17.600 Section 17.600 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Management and Operating Contracts 17.600 Scope of...

48 CFR 17.600 - Scope of subpart.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Scope of subpart. 17.600 Section 17.600 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Management and Operating Contracts 17.600 Scope of...

50 CFR 600.250 - Council member training.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Council member training. 600.250 Section 600.250 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.250 Council...

50 CFR 600.150 - Disposition of records.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Disposition of records. 600.150 Section 600.150 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Regional Fishery Management Councils § 600...

50 CFR 600.150 - Disposition of records.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Disposition of records. 600.150 Section 600.150 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Regional Fishery Management Councils § 600...

50 CFR 600.150 - Disposition of records.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Disposition of records. 600.150 Section 600.150 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Regional Fishery Management Councils § 600...

48 CFR 911.600 - Scope of subpart.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Scope of subpart. 911.600 Section 911.600 Federal Acquisition Regulations System DEPARTMENT OF ENERGY COMPETITION ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Priorities and Allocations 911.600 Scope of subpart. This subpart...

48 CFR 911.600 - Scope of subpart.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Scope of subpart. 911.600 Section 911.600 Federal Acquisition Regulations System DEPARTMENT OF ENERGY COMPETITION ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Priorities and Allocations 911.600 Scope of subpart. This subpart...

48 CFR 911.600 - Scope of subpart.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Scope of subpart. 911.600 Section 911.600 Federal Acquisition Regulations System DEPARTMENT OF ENERGY COMPETITION ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Priorities and Allocations 911.600 Scope of subpart. This subpart...

48 CFR 911.600 - Scope of subpart.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Scope of subpart. 911.600 Section 911.600 Federal Acquisition Regulations System DEPARTMENT OF ENERGY COMPETITION ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Priorities and Allocations 911.600 Scope of subpart. This subpart...

48 CFR 911.600 - Scope of subpart.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Scope of subpart. 911.600 Section 911.600 Federal Acquisition Regulations System DEPARTMENT OF ENERGY COMPETITION ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Priorities and Allocations 911.600 Scope of subpart. This subpart...

10 CFR 600.304 - Special award conditions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Special award conditions. 600.304 Section 600.304 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES Administrative Requirements for Grants and Cooperative Agreements With For-Profit Organizations General § 600.304 Special...

40 CFR 600.011 - Incorporation by reference.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Incorporation by reference. 600.011 Section 600.011 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES General Provisions § 600.011 Incorporation...

40 CFR 600.301-12 - General applicability.

Code of Federal Regulations, 2010 CFR

2010-07-01

... and Later Model Year Automobiles-Labeling § 600.301-12 General applicability. (a) Unless otherwise... 40 Protection of Environment 29 2010-07-01 2010-07-01 false General applicability. 600.301-12 Section 600.301-12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY...

40 CFR 600.316-78 - Multistage manufacture.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Multistage manufacture. 600.316-78 Section 600.316-78 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY... and Later Model Year Automobiles-Labeling § 600.316-78 Multistage manufacture. Where more than one...

10 CFR 490.600 - Purpose and scope.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Purpose and scope. 490.600 Section 490.600 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Investigations and Enforcement § 490.600 Purpose and scope. This subpart sets forth the rules applicable to investigations under...

10 CFR 490.600 - Purpose and scope.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 3 2011-01-01 2011-01-01 false Purpose and scope. 490.600 Section 490.600 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Investigations and Enforcement § 490.600 Purpose and scope. This subpart sets forth the rules applicable to investigations under...

10 CFR 490.600 - Purpose and scope.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 3 2013-01-01 2013-01-01 false Purpose and scope. 490.600 Section 490.600 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Investigations and Enforcement § 490.600 Purpose and scope. This subpart sets forth the rules applicable to investigations under...

10 CFR 490.600 - Purpose and scope.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 3 2012-01-01 2012-01-01 false Purpose and scope. 490.600 Section 490.600 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Investigations and Enforcement § 490.600 Purpose and scope. This subpart sets forth the rules applicable to investigations under...

10 CFR 490.600 - Purpose and scope.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 3 2014-01-01 2014-01-01 false Purpose and scope. 490.600 Section 490.600 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Investigations and Enforcement § 490.600 Purpose and scope. This subpart sets forth the rules applicable to investigations under...

48 CFR 917.600 - Scope of subpart.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Scope of subpart. 917.600 Section 917.600 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Management and Operating Contracts 917.600 Scope of subpart. (a...

48 CFR 917.600 - Scope of subpart.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Scope of subpart. 917.600 Section 917.600 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Management and Operating Contracts 917.600 Scope of subpart. (a...

48 CFR 917.600 - Scope of subpart.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Scope of subpart. 917.600 Section 917.600 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Management and Operating Contracts 917.600 Scope of subpart. (a...

40 CFR 272.600-272.649 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 26 2010-07-01 2010-07-01 false [Reserved] 272.600-272.649 Section 272.600-272.649 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Hawaii §§ 272.600-272.649 [Reserved] ...

40 CFR 272.600-272.649 - [Reserved

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 27 2014-07-01 2014-07-01 false [Reserved] 272.600-272.649 Section 272.600-272.649 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Hawaii §§ 272.600-272.649 [Reserved] ...

40 CFR 272.600-272.649 - [Reserved

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 27 2011-07-01 2011-07-01 false [Reserved] 272.600-272.649 Section 272.600-272.649 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Hawaii §§ 272.600-272.649 [Reserved] ...

40 CFR 272.600-272.649 - [Reserved

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 28 2013-07-01 2013-07-01 false [Reserved] 272.600-272.649 Section 272.600-272.649 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Hawaii §§ 272.600-272.649 [Reserved] ...

40 CFR 272.600-272.649 - [Reserved

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 28 2012-07-01 2012-07-01 false [Reserved] 272.600-272.649 Section 272.600-272.649 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Hawaii §§ 272.600-272.649 [Reserved] ...

40 CFR 600.316-08 - Multistage manufacture.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 31 2013-07-01 2013-07-01 false Multistage manufacture. 600.316-08 Section 600.316-08 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Labeling § 600.316-08...

40 CFR 600.316-08 - Multistage manufacture.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Multistage manufacture. 600.316-08 Section 600.316-08 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Labeling § 600.316-08...

40 CFR 600.316-08 - Multistage manufacture.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Multistage manufacture. 600.316-08 Section 600.316-08 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Labeling § 600.316-08...

High-pressure Xenon Gas Electroluminescent TPC Concept for Simultaneous Searches for Neutrino-less Double Beta Decay & WIMP Dark Matter

NASA Astrophysics Data System (ADS)

Nygren, David

2013-04-01

Xenon is an especially attractive candidate for both direct WIMP and 0- decay searches. Although the current trend has exploited the liquid phase, gas phase xenon offers some remarkable performance advantages for energy resolution, topology visualization, and discrimination between electron and nuclear recoils. The NEXT-100 experiment, now beginning construction in the Canfranc Underground Laboratory, Spain, will operate at 12 bars with 100 kg of ^136Xe for the 0- decay search. I will describe recent results with small prototypes, indicating that NEXT-100 can provide about 0.5% FWHM energy resolution at the decay 2457.83 keV Q-value, as well as rejection of -rays by topology. However, sensitivity goals for WIMP dark matter and 0- decay searches indicate the need for ton-scale active masses; NEXT-100 provides the springboard to reach this scale with xenon gas. I describe a scenario for performing both searches in a single high-pressure ton-scale xenon gas detector, without significant compromise to either. In addition, -- even in a single, ton-scale, high-pressure xenon gas TPC, an intrinsic sensitivity to the nuclear recoil direction may exist -- plausibly offering an advance of more than two orders of magnitude relative to current low-pressure TPC concepts. I argue that, in an era of deepening fiscal austerity, such a dual-purpose detector may be possible, at acceptable cost, within the time frame of interest, and deserves our collective attention.

21 CFR 558.600 - Tiamulin.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 6 2013-04-01 2013-04-01 false Tiamulin. 558.600 Section 558.600 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS NEW ANIMAL DRUGS FOR USE IN ANIMAL FEEDS Specific New Animal Drugs for Use in...

21 CFR 558.600 - Tiamulin.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 6 2012-04-01 2012-04-01 false Tiamulin. 558.600 Section 558.600 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS NEW ANIMAL DRUGS FOR USE IN ANIMAL FEEDS Specific New Animal Drugs for Use in...

21 CFR 558.600 - Tiamulin.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 6 2014-04-01 2014-04-01 false Tiamulin. 558.600 Section 558.600 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS NEW ANIMAL DRUGS FOR USE IN ANIMAL FEEDS Specific New Animal Drugs for Use in...

21 CFR 73.600 - Turmeric.

Code of Federal Regulations, 2011 CFR

2011-04-01

... mixtures for coloring foods. (b) Uses and restrictions. Turmeric may be safely used for the coloring of... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Turmeric. 73.600 Section 73.600 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR...

50 CFR 600.1203 - Prohibitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Shark Finning § 600.1203 Prohibitions. (a) In addition..., any of the following: (1) Engage in shark finning, as provided in § 600.1204(a) and (i). (2) Possess shark fins without the corresponding carcasses while on board a U.S. fishing vessel, as provided in...

50 CFR 600.1203 - Prohibitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Shark Finning § 600.1203 Prohibitions. (a) In addition..., any of the following: (1) Engage in shark finning, as provided in § 600.1204(a) and (i). (2) Possess shark fins without the corresponding carcasses while on board a U.S. fishing vessel, as provided in...

50 CFR 600.1203 - Prohibitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Shark Finning § 600.1203 Prohibitions. (a) In addition..., any of the following: (1) Engage in shark finning, as provided in § 600.1204(a) and (i). (2) Possess shark fins without the corresponding carcasses while on board a U.S. fishing vessel, as provided in...

50 CFR 600.1203 - Prohibitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

..., DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Shark Finning § 600.1203 Prohibitions. (a) In addition..., any of the following: (1) Engage in shark finning, as provided in § 600.1204(a) and (i). (2) Possess shark fins without the corresponding carcasses while on board a U.S. fishing vessel, as provided in...

50 CFR 600.1203 - Prohibitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Shark Finning § 600.1203 Prohibitions. (a) In addition..., any of the following: (1) Engage in shark finning, as provided in § 600.1204(a) and (i). (2) Possess shark fins without the corresponding carcasses while on board a U.S. fishing vessel, as provided in...

21 CFR 600.20 - Inspectors.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Inspectors. 600.20 Section 600.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL... control of products and designated for such purposes by the Commissioner of Food and Drugs, or by any...

21 CFR 600.20 - Inspectors.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Inspectors. 600.20 Section 600.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL... control of products and designated for such purposes by the Commissioner of Food and Drugs, or by any...

10 CFR 600.324 - Supplies.

Code of Federal Regulations, 2010 CFR

2010-01-01

... unused supplies. If the inventory of unused supplies exceeds $5,000 in total aggregate value and the... 10 Energy 4 2010-01-01 2010-01-01 false Supplies. 600.324 Section 600.324 Energy DEPARTMENT OF... Supplies. (a) Title vests in the recipient upon acquisition of supplies acquired with Federal funds under...

10 CFR 600.233 - Supplies.

Code of Federal Regulations, 2010 CFR

2010-01-01

... supplies exceeding $5,000 in total aggregate fair market value upon termination or completion of the award... 10 Energy 4 2010-01-01 2010-01-01 false Supplies. 600.233 Section 600.233 Energy DEPARTMENT OF... Supplies. (a) Title. Title to supplies acquired under a grant or subgrant will vest, upon acquisition, in...

21 CFR 558.600 - Tiamulin.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Tiamulin. 558.600 Section 558.600 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS NEW ANIMAL DRUGS FOR USE IN ANIMAL FEEDS Specific New Animal Drugs for Use in...

42 CFR 436.600 - Scope.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 4 2011-10-01 2011-10-01 false Scope. 436.600 Section 436.600 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL... specified in subparts B, C, and D of this part. Subparts H and I of this part prescribe additional financial...

42 CFR 436.600 - Scope.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 4 2010-10-01 2010-10-01 false Scope. 436.600 Section 436.600 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL... specified in subparts B, C, and D of this part. Subparts H and I of this part prescribe additional financial...

28 CFR 600.7 - Conduct and accountability.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Conduct and accountability. 600.7 Section 600.7 Judicial Administration OFFICES OF INDEPENDENT COUNSEL, DEPARTMENT OF JUSTICE GENERAL POWERS OF SPECIAL COUNSEL § 600.7 Conduct and accountability. (a) A Special Counsel shall comply with the rules...

12 CFR 1807.600 - Tracking funds-general.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Tracking funds-general. 1807.600 Section 1807.600 Banks and Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY CAPITAL MAGNET FUND Tracking Requirements § 1807.600 Tracking funds—general. An Awardee receiving a CMF...

10 CFR 600.111 - Pre-award policies.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Requirements for Grants and Cooperative Agreements With Institutions of Higher Education, Hospitals, and Other Nonprofit Organizations Pre-Award Requirements § 600.111 Pre-award policies. (a) Use of Grants and... 10 Energy 4 2014-01-01 2014-01-01 false Pre-award policies. 600.111 Section 600.111 Energy...

50 CFR 600.5 - Purpose and scope.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Purpose and scope. 600.5 Section 600.5 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS General § 600.5 Purpose and scope. (a) This part...

50 CFR 600.220 - Oath of office.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Oath of office. 600.220 Section 600.220 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.220 Oath of office. As...

50 CFR 600.225 - Rules of conduct.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Rules of conduct. 600.225 Section 600.225 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.225 Rules of conduct. (a...

50 CFR 600.5 - Purpose and scope.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Purpose and scope. 600.5 Section 600.5 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS General § 600.5 Purpose and scope. (a) This part...

50 CFR 600.5 - Purpose and scope.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Purpose and scope. 600.5 Section 600.5 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS General § 600.5 Purpose and scope. (a) This part...

50 CFR 600.805 - Purpose and scope.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Purpose and scope. 600.805 Section 600.805 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Essential Fish Habitat (EFH) § 600.805 Purpose and...

46 CFR 308.600 - Records retention requirement.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 8 2011-10-01 2011-10-01 false Records retention requirement. 308.600 Section 308.600 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE Records Retention § 308.600 Records retention requirement. The records specified in §§ 308.8, 308.517, and...

46 CFR 308.600 - Records retention requirement.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 8 2012-10-01 2012-10-01 false Records retention requirement. 308.600 Section 308.600 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE Records Retention § 308.600 Records retention requirement. The records specified in §§ 308.8, 308.517, and...

46 CFR 308.600 - Records retention requirement.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Records retention requirement. 308.600 Section 308.600 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE Records Retention § 308.600 Records retention requirement. The records specified in §§ 308.8, 308.517, and...

46 CFR 308.600 - Records retention requirement.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 8 2014-10-01 2014-10-01 false Records retention requirement. 308.600 Section 308.600 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE Records Retention § 308.600 Records retention requirement. The records specified in §§ 308.8, 308.517, and...

46 CFR 308.600 - Records retention requirement.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 8 2013-10-01 2013-10-01 false Records retention requirement. 308.600 Section 308.600 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE Records Retention § 308.600 Records retention requirement. The records specified in §§ 308.8, 308.517, and...

10 CFR 600.20 - Maximum DOE obligation.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Maximum DOE obligation. 600.20 Section 600.20 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES General § 600.20 Maximum DOE obligation. (a) The maximum DOE obligation to the recipient is— (1) For monetary awards, the...

50 CFR 600.415 - Access to statistics.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Access to statistics. 600.415 Section 600... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Confidentiality of Statistics § 600.415 Access to statistics. (a) General. In determining whether to grant a request for access to confidential...

50 CFR 600.425 - Release of statistics.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Release of statistics. 600.425 Section 600... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Confidentiality of Statistics § 600.425 Release of statistics. (a) The Assistant Administrator will not release to the public any statistics...

30 CFR 71.600 - Drinking water; general.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Drinking water; general. 71.600 Section 71.600 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH... Water § 71.600 Drinking water; general. An adequate supply of potable water shall be provided for...

30 CFR 71.600 - Drinking water; general.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Drinking water; general. 71.600 Section 71.600 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH... Water § 71.600 Drinking water; general. An adequate supply of potable water shall be provided for...

45 CFR 1168.600 - Semi-annual compilation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 3 2011-10-01 2011-10-01 false Semi-annual compilation. 1168.600 Section 1168.600 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE HUMANITIES NEW RESTRICTIONS ON LOBBYING Agency Reports § 1168.600 Semi...

45 CFR 1168.600 - Semi-annual compilation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false Semi-annual compilation. 1168.600 Section 1168.600 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE HUMANITIES NEW RESTRICTIONS ON LOBBYING Agency Reports § 1168.600 Semi...

7 CFR 600.8 - Plant materials centers.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 6 2013-01-01 2013-01-01 false Plant materials centers. 600.8 Section 600.8..., DEPARTMENT OF AGRICULTURE GENERAL ORGANIZATION § 600.8 Plant materials centers. Plant materials centers (PMC) assemble and test plant species for conservation uses. Usually a PMC serves two or more States, and is...

7 CFR 600.8 - Plant materials centers.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 6 2012-01-01 2012-01-01 false Plant materials centers. 600.8 Section 600.8..., DEPARTMENT OF AGRICULTURE GENERAL ORGANIZATION § 600.8 Plant materials centers. Plant materials centers (PMC) assemble and test plant species for conservation uses. Usually a PMC serves two or more States, and is...

7 CFR 600.8 - Plant materials centers.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 6 2011-01-01 2011-01-01 false Plant materials centers. 600.8 Section 600.8..., DEPARTMENT OF AGRICULTURE GENERAL ORGANIZATION § 600.8 Plant materials centers. Plant materials centers (PMC) assemble and test plant species for conservation uses. Usually a PMC serves two or more States, and is...

7 CFR 600.8 - Plant materials centers.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false Plant materials centers. 600.8 Section 600.8..., DEPARTMENT OF AGRICULTURE GENERAL ORGANIZATION § 600.8 Plant materials centers. Plant materials centers (PMC) assemble and test plant species for conservation uses. Usually a PMC serves two or more States, and is...

7 CFR 600.8 - Plant materials centers.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 6 2014-01-01 2014-01-01 false Plant materials centers. 600.8 Section 600.8..., DEPARTMENT OF AGRICULTURE GENERAL ORGANIZATION § 600.8 Plant materials centers. Plant materials centers (PMC) assemble and test plant species for conservation uses. Usually a PMC serves two or more States, and is...

21 CFR 600.22 - Duties of inspector.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Duties of inspector. 600.22 Section 600.22 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL PRODUCTS: GENERAL Establishment Inspection § 600.22 Duties of inspector. The inspector shall: (a...

21 CFR 600.22 - Duties of inspector.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Duties of inspector. 600.22 Section 600.22 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL PRODUCTS: GENERAL Establishment Inspection § 600.22 Duties of inspector. The inspector shall: (a...

10 CFR 600.137 - Property trust relationship.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Property trust relationship. 600.137 Section 600.137..., Hospitals, and Other Nonprofit Organizations Post-Award Requirements § 600.137 Property trust relationship... Federal funds shall be held in trust by the recipient as trustee for the beneficiaries of the project or...

30 CFR 71.600 - Drinking water; general.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Drinking water; general. 71.600 Section 71.600 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH... Water § 71.600 Drinking water; general. An adequate supply of potable water shall be provided for...

30 CFR 71.600 - Drinking water; general.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Drinking water; general. 71.600 Section 71.600 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH... Water § 71.600 Drinking water; general. An adequate supply of potable water shall be provided for...

30 CFR 71.600 - Drinking water; general.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Drinking water; general. 71.600 Section 71.600 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH... Water § 71.600 Drinking water; general. An adequate supply of potable water shall be provided for...

21 CFR 600.21 - Time of inspection.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Time of inspection. 600.21 Section 600.21 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL PRODUCTS: GENERAL Establishment Inspection § 600.21 Time of inspection. The inspection of an...

24 CFR 87.600 - Semi-annual compilation.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Semi-annual compilation. 87.600 Section 87.600 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development NEW RESTRICTIONS ON LOBBYING Agency Reports § 87.600 Semi-annual compilation. (a) The head of each...

12 CFR 411.600 - Semi-annual compilation.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Semi-annual compilation. 411.600 Section 411.600 Banks and Banking EXPORT-IMPORT BANK OF THE UNITED STATES NEW RESTRICTIONS ON LOBBYING Agency Reports § 411.600 Semi-annual compilation. (a) The head of each agency shall collect and compile the...

32 CFR 28.600 - Semi-annual compilation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false Semi-annual compilation. 28.600 Section 28.600 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS NEW RESTRICTIONS ON LOBBYING Agency Reports § 28.600 Semi-annual compilation. (a) The head of each...

32 CFR 28.600 - Semi-annual compilation.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 1 2014-07-01 2014-07-01 false Semi-annual compilation. 28.600 Section 28.600 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS NEW RESTRICTIONS ON LOBBYING Agency Reports § 28.600 Semi-annual compilation. (a) The head of each...

32 CFR 28.600 - Semi-annual compilation.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 1 2013-07-01 2013-07-01 false Semi-annual compilation. 28.600 Section 28.600 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS NEW RESTRICTIONS ON LOBBYING Agency Reports § 28.600 Semi-annual compilation. (a) The head of each...

32 CFR 28.600 - Semi-annual compilation.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 1 2012-07-01 2012-07-01 false Semi-annual compilation. 28.600 Section 28.600 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS NEW RESTRICTIONS ON LOBBYING Agency Reports § 28.600 Semi-annual compilation. (a) The head of each...

32 CFR 28.600 - Semi-annual compilation.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 1 2011-07-01 2011-07-01 false Semi-annual compilation. 28.600 Section 28.600 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS NEW RESTRICTIONS ON LOBBYING Agency Reports § 28.600 Semi-annual compilation. (a) The head of each...

40 CFR 600.011 - Incorporation by reference.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 1, 2010, IBR approved for §§ 600.113-08(f) and 600.113-12(f). (c) Society of Automotive Engineers... 1100a (Report of Human Factors Engineering Committee, Society of Automotive Engineers, approved September 1973 as revised September 1975), IBR approved for § 600.315-08(c). (2) SAE J1634, Electric Vehicle...

40 CFR 600.011 - Incorporation by reference.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 1, 2010, IBR approved for §§ 600.113-08(f) and 600.113-12(f). (c) Society of Automotive Engineers... 1100a (Report of Human Factors Engineering Committee, Society of Automotive Engineers, approved September 1973 as revised September 1975), IBR approved for § 600.315-08(c). (2) SAE J1634, Electric Vehicle...

34 CFR 600.40 - Loss of eligibility.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false Loss of eligibility. 600.40 Section 600.40 Education..., DEPARTMENT OF EDUCATION INSTITUTIONAL ELIGIBILITY UNDER THE HIGHER EDUCATION ACT OF 1965, AS AMENDED Loss of Eligibility § 600.40 Loss of eligibility. (a)(1) Except as provided in paragraphs (a) (2) and (3) of this...

12 CFR 600.10 - Service of Process.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Service of Process. 600.10 Section 600.10 Banks... Procedures for Service Upon the Farm Credit Administration § 600.10 Service of Process. (a) Except as... Administration Board, 1501 Farm Credit Drive, McLean, Virginia 22102-5090. (b) Service of process upon the...

Demonstrator Detection System for the Active Target and Time Projection Chamber (ACTAR TPC) project

NASA Astrophysics Data System (ADS)

Roger, T.; Pancin, J.; Grinyer, G. F.; Mauss, B.; Laffoley, A. T.; Rosier, P.; Alvarez-Pol, H.; Babo, M.; Blank, B.; Caamaño, M.; Ceruti, S.; Daemen, J.; Damoy, S.; Duclos, B.; Fernández-Domínguez, B.; Flavigny, F.; Giovinazzo, J.; Goigoux, T.; Henares, J. L.; Konczykowski, P.; Marchi, T.; Lebertre, G.; Lecesne, N.; Legeard, L.; Maugeais, C.; Minier, G.; Osmond, B.; Pedroza, J. L.; Pibernat, J.; Poleshchuk, O.; Pollacco, E. C.; Raabe, R.; Raine, B.; Renzi, F.; Saillant, F.; Sénécal, P.; Sizun, P.; Suzuki, D.; Swartz, J. A.; Wouters, C.; Wittwer, G.; Yang, J. C.

2018-07-01

The design, realization and operation of a prototype or "demonstrator" version of an active target and time projection chamber (ACTAR TPC) for experiments in nuclear physics is presented in detail. The heart of the detection system features a MICROMEGAS gas amplifier coupled to a high-density pixelated pad plane with square pad sizes of 2 × 2 mm2. The detector has been thoroughly tested with several different gas mixtures over a wide range of pressures and using a variety of sources of ionizing radiation including laser light, an α-particle source and heavy-ion beams of 24Mg and 58Ni accelerated to energies of 4.0 MeV/u. Results from these tests and characterization of the detector response over a wide range of operating conditions will be described. These developments have served as the basis for the design of a larger detection system that is presently under construction.

Development of ultra-short PCR assay to reveal BRAF V600 mutation status in Thai colorectal cancer tissues.

PubMed

Chat-Uthai, Nunthawut; Vejvisithsakul, Pichpisith; Udommethaporn, Sutthirat; Meesiri, Puttarakun; Danthanawanit, Chetiya; Wongchai, Yannawan; Teerapakpinyo, Chinachote; Shuangshoti, Shanop; Poungvarin, Naravat

2018-01-01

The protein kinase BRAF is one of the key players in regulating cellular responses to extracellular signals. Somatic mutations of the BRAF gene, causing constitutive activation of BRAF, have been found in various types of human cancers such as malignant melanoma, and colorectal cancer. BRAF V600E and V600K, most commonly observed mutations in these cancers, may predict response to targeted therapies. Many techniques suffer from a lack of diagnostic sensitivity in mutation analysis in clinical samples with a low cancer cell percentage or poor-quality fragmented DNA. Here we present allele-specific real-time PCR assay for amplifying 35- to 45-base target sequences in BRAF gene. Forward primer designed for BRAF V600E detection is capable of recognizing both types of BRAF V600E mutation, i.e. V600E1 (c.1799T>A) and V600E2 (c.1799_1800delTGinsAA), as well as complex tandem mutation caused by nucleotide changes in codons 600 and 601. We utilized this assay to analyze Thai formalin-fixed paraffin-embedded tissues. Forty-eight percent of 178 Thai colorectal cancer tissues has KRAS mutation detected by highly sensitive commercial assays. Although these DNA samples contain low overall yield of amplifiable DNA, our newly-developed assay successfully revealed BRAF V600 mutations in 6 of 93 formalin-fixed paraffin-embedded colorectal cancer tissues which KRAS mutation was not detected. Ultra-short PCR assay with forward mutation-specific primers is potentially useful to detect BRAF V600 mutations in highly fragmented DNA specimens from cancer patients.

50 CFR 600.740 - Enforcement policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Enforcement policy. 600.740 Section 600.740 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS General Provisions for Domestic Fisheries...

50 CFR 600.1007 - Reduction amendments.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Reduction amendments. 600.1007 Section 600.1007 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC....1007 Reduction amendments. (a) Each reduction amendment may contain provisions that are either...

50 CFR 600.1002 - General requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false General requirements. 600.1002 Section 600.1002 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC....1002 General requirements. (a) Each program must be: (1) Necessary to prevent or end overfishing...

50 CFR 600.1002 - General requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false General requirements. 600.1002 Section 600.1002 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC....1002 General requirements. (a) Each program must be: (1) Necessary to prevent or end overfishing...

50 CFR 600.1002 - General requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false General requirements. 600.1002 Section 600.1002 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC....1002 General requirements. (a) Each program must be: (1) Necessary to prevent or end overfishing...

50 CFR 600.1002 - General requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false General requirements. 600.1002 Section 600.1002 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC....1002 General requirements. (a) Each program must be: (1) Necessary to prevent or end overfishing...

21 CFR 600.2 - Mailing addresses.

Code of Federal Regulations, 2013 CFR

2013-04-01

... BIOLOGICAL PRODUCTS: GENERAL General Provisions § 600.2 Mailing addresses. (a) Licensed biological products... referenced in parts 600 through 680 of this chapter, as applicable, must be sent to: Document Control Center... applications (BLAs) and their amendments and supplements, adverse experience reports, biological product...

21 CFR 600.2 - Mailing addresses.

Code of Federal Regulations, 2014 CFR

2014-04-01

... BIOLOGICAL PRODUCTS: GENERAL General Provisions § 600.2 Mailing addresses. (a) Licensed biological products... referenced in parts 600 through 680 of this chapter, as applicable, must be sent to: Document Control Center... applications (BLAs) and their amendments and supplements, adverse experience reports, biological product...

21 CFR 600.2 - Mailing addresses.

Code of Federal Regulations, 2012 CFR

2012-04-01

... BIOLOGICAL PRODUCTS: GENERAL General Provisions § 600.2 Mailing addresses. (a) Licensed biological products... referenced in parts 600 through 680 of this chapter, as applicable, must be sent to: Document Control Center... applications (BLAs) and their amendments and supplements, adverse experience reports, biological product...

30 CFR 250.600 - General requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 2 2011-07-01 2011-07-01 false General requirements. 250.600 Section 250.600 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE... leased), the national security or defense, or the marine, coastal, or human environment. ...

40 CFR 600.102-78 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Definitions. 600.102-78 Section 600.102-78 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Regulations for 1978 and Later...

40 CFR 600.303-77 - Abbreviations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Abbreviations. 600.303-77 Section 600.303-77 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Regulations for 1977 and Later...

40 CFR 600.302-77 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Definitions. 600.302-77 Section 600.302-77 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Regulations for 1977 and Later...

40 CFR 600.003-77 - Abbreviations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Abbreviations. 600.003-77 Section 600.003-77 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Regulations for 1977 and Later...

40 CFR 600.105-78 - Recordkeeping.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Recordkeeping. 600.105-78 Section 600.105-78 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Regulations for 1978 and Later...

40 CFR 600.305-77 - Recordkeeping.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Recordkeeping. 600.305-77 Section 600.305-77 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Regulations for 1977 and Later...

40 CFR 600.103-78 - Abbreviations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Abbreviations. 600.103-78 Section 600.103-78 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Regulations for 1978 and Later...

10 CFR 600.241 - Financial reporting.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Financial reporting. 600.241 Section 600.241 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES Uniform Administrative....241 Financial reporting. (a) General. (1) Except as provided in paragraphs (a) (2) and (5) of this...

24 CFR 232.600 - Title evidence.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Title evidence. 232.600 Section 232.600 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES MORTGAGE...

50 CFR 600.757 - Operational protocols.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Operational protocols. 600.757 Section 600.757 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Operational protocols. (a) Services of conveners and facilitators. A Council or NMFS may employ or enter into...

10 CFR 600.241 - Financial reporting.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Financial reporting. 600.241 Section 600.241 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES Uniform Administrative....241 Financial reporting. (a) General. (1) Except as provided in paragraphs (a) (2) and (5) of this...

50 CFR 600.330 - National Standard 5-Efficiency.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false National Standard 5-Efficiency. 600.330 Section 600.330 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS National Standards § 600...

50 CFR 600.510 - Gear avoidance and disposal.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Gear avoidance and disposal. 600.510 Section 600.510 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Foreign Fishing § 600.510...

50 CFR 600.512 - Scientific research.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Scientific research. 600.512 Section 600... research. (a) Scientific research activity. Persons planning to conduct scientific research activities on board a scientific research vessel in the EEZ that may be confused with fishing are encouraged to submit...

50 CFR 600.512 - Scientific research.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Scientific research. 600.512 Section 600... research. (a) Scientific research activity. Persons planning to conduct scientific research activities on board a scientific research vessel in the EEZ that may be confused with fishing are encouraged to submit...

50 CFR 600.512 - Scientific research.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Scientific research. 600.512 Section 600... research. (a) Scientific research activity. Persons planning to conduct scientific research activities on board a scientific research vessel in the EEZ that may be confused with fishing are encouraged to submit...

50 CFR 600.512 - Scientific research.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Scientific research. 600.512 Section 600... research. (a) Scientific research activity. Persons planning to conduct scientific research activities on board a scientific research vessel in the EEZ that may be confused with fishing are encouraged to submit...

50 CFR 600.512 - Scientific research.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Scientific research. 600.512 Section 600... research. (a) Scientific research activity. Persons planning to conduct scientific research activities on board a scientific research vessel in the EEZ that may be confused with fishing are encouraged to submit...

50 CFR 600.1012 - Reduction loan.

Code of Federal Regulations, 2010 CFR

2010-10-01

... annual rate, that shall be determined by subsequent events, of simple interest on the reduction loan's... deposit and disburse the fee revenue in accordance with § 600.1014. (b) Principal amount, interest rate... § 600.1014. (c) Effect of prospective interest rate. Any difference between a prospective interest rate...

24 CFR 954.600 - Performance reviews.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Performance reviews. 954.600... DEVELOPMENT INDIAN HOME PROGRAM Performance Reviews and Sanctions § 954.600 Performance reviews. (a) General. HUD will review the performance of each grantee in carrying out its responsibilities under this part...

24 CFR 954.600 - Performance reviews.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false Performance reviews. 954.600... DEVELOPMENT INDIAN HOME PROGRAM Performance Reviews and Sanctions § 954.600 Performance reviews. (a) General. HUD will review the performance of each grantee in carrying out its responsibilities under this part...

50 CFR 600.135 - Meeting procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Meeting procedures. 600.135 Section 600....135 Meeting procedures. Link to an amendment published at 75 FR 59150, Sept. 27, 2010. (a) Public notice of regular meetings of the Council, scientific statistical committee or advisory panels, including...

50 CFR 600.210 - Terms of Council members.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Terms of Council members. 600.210 Section 600.210 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.210 Terms of...

50 CFR 600.210 - Terms of Council members.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Terms of Council members. 600.210 Section 600.210 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.210 Terms of...

50 CFR 600.210 - Terms of Council members.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Terms of Council members. 600.210 Section 600.210 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.210 Terms of...

10 CFR 600.502 - What must DOE determine.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false What must DOE determine. 600.502 Section 600.502 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES Eligibility Determination for Certain Financial Assistance Programs-General Statement of Policy § 600.502 What must DOE...

40 CFR 600.002-93 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... traveled by an automobile or group of automobiles per volume of fuel consumed as computed in § 600.113 or § 600.207; or (ii) The equivalent petroleum-based fuel economy for an electrically powered automobile as... means the equivalent petroleum-based fuel economy value as determined by the calculation procedure...

42 CFR 600.165 - Nondiscrimination standards.

Code of Federal Regulations, 2014 CFR

2014-10-01

... standards. (a) The State and standard health plans, must comply with all applicable civil rights statutes and requirements, including Title VI of the Civil Rights Act of 1964, Title II of the Americans with... 42 Public Health 5 2014-10-01 2014-10-01 false Nondiscrimination standards. 600.165 Section 600...

10 CFR 600.225 - Program income.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Program income. 600.225 Section 600.225 Energy DEPARTMENT....225 Program income. (a) General. Grantees are encouraged to earn income to defray program costs. Program income includes income from fees for services performed, from the use or rental of real or...

21 CFR 600.13 - Retention samples.

Code of Federal Regulations, 2011 CFR

2011-04-01

... specific products required to be submitted to the Center for Biologics Evaluation and Research or the... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Retention samples. 600.13 Section 600.13 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS...

21 CFR 600.13 - Retention samples.

Code of Federal Regulations, 2010 CFR

2010-04-01

... specific products required to be submitted to the Center for Biologics Evaluation and Research or the... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Retention samples. 600.13 Section 600.13 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS...

40 CFR 600.109-08 - EPA driving cycles.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 30 2011-07-01 2011-07-01 false EPA driving cycles. 600.109-08 Section 600.109-08 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL... Emission Regulations for 1978 and Later Model Year Automobiles-Test Procedures § 600.109-08 EPA driving...

40 CFR 600.109-78 - EPA driving cycles.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 30 2011-07-01 2011-07-01 false EPA driving cycles. 600.109-78 Section 600.109-78 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL... Emission Regulations for 1978 and Later Model Year Automobiles-Test Procedures § 600.109-78 EPA driving...

50 CFR 600.705 - Relation to other laws.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Relation to other laws. 600.705 Section 600.705 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 600.705 Relation to other laws. (a) General. Persons affected by these regulations should be aware...

50 CFR 600.705 - Relation to other laws.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Relation to other laws. 600.705 Section 600.705 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 600.705 Relation to other laws. (a) General. Persons affected by these regulations should be aware...

50 CFR 600.705 - Relation to other laws.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Relation to other laws. 600.705 Section 600.705 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 600.705 Relation to other laws. (a) General. Persons affected by these regulations should be aware...

50 CFR 600.405 - Types of statistics covered.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Types of statistics covered. 600.405 Section 600.405 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND... Statistics § 600.405 Types of statistics covered. NOAA is authorized under the Magnuson-Stevens Act and other...

50 CFR 600.705 - Relation to other laws.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Relation to other laws. 600.705 Section 600.705 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 600.705 Relation to other laws. (a) General. Persons affected by these regulations should be aware...

10 CFR 600.145 - Cost and price analysis.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Cost and price analysis. 600.145 Section 600.145 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES Uniform Administrative... Nonprofit Organizations Post-Award Requirements § 600.145 Cost and price analysis. Some form of cost or...

10 CFR 600.102 - Effect on other issuances.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Effect on other issuances. 600.102 Section 600.102 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES Uniform Administrative... Nonprofit Organizations General § 600.102 Effect on other issuances. For awards subject to this subpart, all...

10 CFR 600.102 - Effect on other issuances.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Effect on other issuances. 600.102 Section 600.102 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES Uniform Administrative... Nonprofit Organizations General § 600.102 Effect on other issuances. For awards subject to this subpart, all...

10 CFR 600.204 - Effect on other issuances.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Effect on other issuances. 600.204 Section 600.204 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES Uniform Administrative Requirements for Grants and Cooperative Agreements to State and Local Governments General § 600.204 Effect on...

50 CFR 600.405 - Types of statistics covered.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Types of statistics covered. 600.405 Section 600.405 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND... Statistics § 600.405 Types of statistics covered. NOAA is authorized under the Magnuson-Stevens Act and other...

18 CFR 154.600 - Compliance with other subparts.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Compliance with other subparts. 154.600 Section 154.600 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... Changes § 154.600 Compliance with other subparts. Any proposal to implement a tariff change other than in...

18 CFR 154.600 - Compliance with other subparts.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Compliance with other subparts. 154.600 Section 154.600 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... Changes § 154.600 Compliance with other subparts. Any proposal to implement a tariff change other than in...

18 CFR 154.600 - Compliance with other subparts.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Compliance with other subparts. 154.600 Section 154.600 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... Changes § 154.600 Compliance with other subparts. Any proposal to implement a tariff change other than in...

18 CFR 154.600 - Compliance with other subparts.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Compliance with other subparts. 154.600 Section 154.600 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... Changes § 154.600 Compliance with other subparts. Any proposal to implement a tariff change other than in...

18 CFR 154.600 - Compliance with other subparts.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Compliance with other subparts. 154.600 Section 154.600 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... Changes § 154.600 Compliance with other subparts. Any proposal to implement a tariff change other than in...

10 CFR 600.231 - Real property.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Real property. 600.231 Section 600.231 Energy DEPARTMENT....231 Real property. (a) Title. Subject to the obligations and conditions set forth in this section, title to real property acquired under a grant or subgrant will vest upon acquisition in the grantee or...

10 CFR 600.231 - Real property.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Real property. 600.231 Section 600.231 Energy DEPARTMENT....231 Real property. (a) Title. Subject to the obligations and conditions set forth in this section, title to real property acquired under a grant or subgrant will vest upon acquisition in the grantee or...

10 CFR 600.231 - Real property.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Real property. 600.231 Section 600.231 Energy DEPARTMENT....231 Real property. (a) Title. Subject to the obligations and conditions set forth in this section, title to real property acquired under a grant or subgrant will vest upon acquisition in the grantee or...

10 CFR 600.231 - Real property.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Real property. 600.231 Section 600.231 Energy DEPARTMENT....231 Real property. (a) Title. Subject to the obligations and conditions set forth in this section, title to real property acquired under a grant or subgrant will vest upon acquisition in the grantee or...

10 CFR 600.231 - Real property.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Real property. 600.231 Section 600.231 Energy DEPARTMENT....231 Real property. (a) Title. Subject to the obligations and conditions set forth in this section, title to real property acquired under a grant or subgrant will vest upon acquisition in the grantee or...

10 CFR 600.115 - Metric system of measurement.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Metric system of measurement. 600.115 Section 600.115..., Hospitals, and Other Nonprofit Organizations Pre-Award Requirements § 600.115 Metric system of measurement...) declares that the metric system is the preferred measurement system for U.S. trade and commerce. The Act...

10 CFR 600.115 - Metric system of measurement.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Metric system of measurement. 600.115 Section 600.115..., Hospitals, and Other Nonprofit Organizations Pre-Award Requirements § 600.115 Metric system of measurement...) declares that the metric system is the preferred measurement system for U.S. trade and commerce. The Act...

10 CFR 600.115 - Metric system of measurement.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Metric system of measurement. 600.115 Section 600.115..., Hospitals, and Other Nonprofit Organizations Pre-Award Requirements § 600.115 Metric system of measurement...) declares that the metric system is the preferred measurement system for U.S. trade and commerce. The Act...

10 CFR 600.115 - Metric system of measurement.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Metric system of measurement. 600.115 Section 600.115..., Hospitals, and Other Nonprofit Organizations Pre-Award Requirements § 600.115 Metric system of measurement...) declares that the metric system is the preferred measurement system for U.S. trade and commerce. The Act...

10 CFR 600.115 - Metric system of measurement.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Metric system of measurement. 600.115 Section 600.115..., Hospitals, and Other Nonprofit Organizations Pre-Award Requirements § 600.115 Metric system of measurement...) declares that the metric system is the preferred measurement system for U.S. trade and commerce. The Act...

28 CFR 600.10 - No creation of rights.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false No creation of rights. 600.10 Section 600.10 Judicial Administration OFFICES OF INDEPENDENT COUNSEL, DEPARTMENT OF JUSTICE GENERAL POWERS OF SPECIAL COUNSEL § 600.10 No creation of rights. The regulations in this part are not intended to, do not...

28 CFR 600.10 - No creation of rights.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 2 2013-07-01 2013-07-01 false No creation of rights. 600.10 Section 600.10 Judicial Administration OFFICES OF INDEPENDENT COUNSEL, DEPARTMENT OF JUSTICE GENERAL POWERS OF SPECIAL COUNSEL § 600.10 No creation of rights. The regulations in this part are not intended to, do not...

28 CFR 600.10 - No creation of rights.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 2 2012-07-01 2012-07-01 false No creation of rights. 600.10 Section 600.10 Judicial Administration OFFICES OF INDEPENDENT COUNSEL, DEPARTMENT OF JUSTICE GENERAL POWERS OF SPECIAL COUNSEL § 600.10 No creation of rights. The regulations in this part are not intended to, do not...

28 CFR 600.10 - No creation of rights.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 2 2014-07-01 2014-07-01 false No creation of rights. 600.10 Section 600.10 Judicial Administration OFFICES OF INDEPENDENT COUNSEL, DEPARTMENT OF JUSTICE GENERAL POWERS OF SPECIAL COUNSEL § 600.10 No creation of rights. The regulations in this part are not intended to, do not...

28 CFR 600.10 - No creation of rights.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 2 2011-07-01 2011-07-01 false No creation of rights. 600.10 Section 600.10 Judicial Administration OFFICES OF INDEPENDENT COUNSEL, DEPARTMENT OF JUSTICE GENERAL POWERS OF SPECIAL COUNSEL § 600.10 No creation of rights. The regulations in this part are not intended to, do not...

40 CFR 600.011-93 - Reference materials.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Natural Gas By Gas Chromatography, IBR approved for §§ 600.113-93, 600.113-08. (c) SAE Material. The... obtained from Society of Automotive Engineers World Headquarters, 400 Commonwealth Dr., Warrendale, PA...

40 CFR 600.002-93 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

...) The average number of miles traveled by an automobile or group of automobiles per volume of fuel consumed as computed in § 600.113 or § 600.207; or (ii) The equivalent petroleum-based fuel economy for an... vehicles, the term means the equivalent petroleum-based fuel economy value as determined by the calculation...

40 CFR 600.002-85 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... differential (or equivalent) turns for each turn of the drive wheels. (29) “Auxiliary Emission Control Device... miles traveled by an automobile or group of automobiles per gallon of gasoline or diesel fuel consumed as computed in § 600.113 or § 600.207 or (ii) the equivalent petroleum-based fuel economy for an...

A HRM assay for identification of low level BRAF V600E and V600K mutations using the CADMA principle in FFPE specimens.

PubMed

Huebner, Claudia; Weber, Remeny; Lloydd, Richard

2017-12-01

Melanoma patients with BRAF V600E and V600K mutations show complete or partial response to vemurafenib. Detection assays often scan for the common V600E mutation rather than the rare V600K variant, although this mutation can be found in a high proportion of melanoma patients in the South Pacific. Herein, we describe a BRAF high resolution melting (HRM) assay that can differentiate low level of V600E and V600K mutations using formalin fixed, paraffin embedded (FFPE) reference standards for assay validation. The assay is based on the competitive amplification of differentially melting amplicons (CADMA principle) and has a limit of detection of 0.8% mutant allele for V600K and 1.4% mutant allele for V600E. A differentiation between the two mutations based on the melting profile is possible even at low mutation level. Sixty FFPE specimens were scanned and mutations could be scored correctly as confirmed by castPCR. In summary, the developed HRM assay is suitable for detection of V600K and V600E mutations and proved to be reliable and cost effective in a diagnostic environment. Copyright © 2017 Royal College of Pathologists of Australasia. Published by Elsevier B.V. All rights reserved.

50 CFR 600.520 - Northwest Atlantic Ocean fishery.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Northwest Atlantic Ocean fishery. 600.520... Northwest Atlantic Ocean fishery. (a) Purpose. Sections 600.520 and 600.525 regulate all foreign fishing conducted under a GIFA within the EEZ in the Atlantic Ocean north of 35°00′ N. lat. (b) Authorized fishery...

50 CFR 600.520 - Northwest Atlantic Ocean fishery.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Northwest Atlantic Ocean fishery. 600.520... Northwest Atlantic Ocean fishery. (a) Purpose. Sections 600.520 and 600.525 regulate all foreign fishing conducted under a GIFA within the EEZ in the Atlantic Ocean north of 35°00′ N. lat. (b) Authorized fishery...

50 CFR 600.520 - Northwest Atlantic Ocean fishery.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Northwest Atlantic Ocean fishery. 600.520... Northwest Atlantic Ocean fishery. (a) Purpose. Sections 600.520 and 600.525 regulate all foreign fishing conducted under a GIFA within the EEZ in the Atlantic Ocean north of 35°00′ N. lat. (b) Authorized fishery...

50 CFR 600.520 - Northwest Atlantic Ocean fishery.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Northwest Atlantic Ocean fishery. 600.520... Northwest Atlantic Ocean fishery. (a) Purpose. Sections 600.520 and 600.525 regulate all foreign fishing conducted under a GIFA within the EEZ in the Atlantic Ocean north of 35°00′ N. lat. (b) Authorized fishery...

50 CFR 600.1201 - Relation to other laws.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Relation to other laws. 600.1201 Section... laws. (a) The relation of this subpart to other laws is set forth in §§ 600.514 and 600.705 and in...) Nothing in this regulation supercedes more restrictive state laws or regulations regarding shark finning...

10 CFR 600.120 - Purpose of financial and program management.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Purpose of financial and program management. 600.120 Section 600.120 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES... financial and program management. Sections 600.121 through 600.128 prescribe standards for financial...

A Prototype Combination TPC Cherenkov Detector with GEM Readout for Tracking and Particle Identification and its Potential Use at an Electron Ion Collider

NASA Astrophysics Data System (ADS)

Woody, Craig; Azmoun, Babak; Majka, Richard; Phipps, Michael; Purschke, Martin; Smirnov, Nikolai

2018-02-01

A prototype detector is being developed which combines the functions of a Time Projection Chamber for charged particle tracking and a Cherenkov detector for particle identification. The TPC consists of a 10×10×10 cm3 drift volume where the charge is drifted to a 10×10 cm2 triple GEM detector. The charge is measured on a readout plane consisting of 2×10 mm2 chevron pads which provide a spatial resolution ˜ 100 μm per point in the chevron direction along with dE/dx information. The Cherenkov portion of the detector consists of a second 10×10 cm2 triple GEM with a photosensitive CsI photocathode on the top layer. This detector measures Cherenkov light produced in the drift gas of the TPC by high velocity particles which are above threshold. CF4 or CF4 mixtures will be used as the drift gas which are highly transparent to UV light and can provide excellent efficiency for detecting Cherenkov photons. The drift gas is also used as the operating gas for both GEM detectors. The prototype detector has been constructed and is currently being tested in the lab with sources and cosmic rays, and additional tests are planned in the future to study the detector in a test beam.

Acquired BRAF V600E Mutation as Resistant Mechanism after Treatment with Osimertinib.

PubMed

Ho, Chao-Chi; Liao, Wei-Yu; Lin, Chih-An; Shih, Jin-Yuan; Yu, Chong-Jen; Chih-Hsin Yang, James

2017-03-01

AZD9291 (osimertinib) is designed for acquired T790M mutation after first- and second-generation EGFR) tyrosine kinase inhibitors have been used. Some of the resistance mechanisms that present after osimertinib treatment, including a newly acquired EGFR C797S mutation, have been identified. It is unclear, however, whether the bypass pathway is also a mechanism of resistance in patients after osimertinib treatment. Cells from malignant pleural effusion were collected and cultured at the time of progression in a patient being treated with osimertinib. Tumor genotyping was done by matrix-assisted laser desorption ionization-time of flight mass spectrometry. EGFR, AKT, MEK, and ERK phosphorylation were determined. An anchorage-dependent colony formation assay was used for drug sensitivity. An acquired mutation, BRAF V600E, was found in the patient at the time of progression while being treated with osimertinib. Cells grown from malignant pleural effusion were sensitive to BRAF V600E inhibitor and were more vulnerable to a combination treatment with osimertinib. A potential mechanism of acquired resistance to osimertinib in patients with T790M is through the BRAF pathway. Simultaneous blockade of the BRAF and EGFR had a significant inhibitory effect. Copyright © 2016 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

48 CFR 217.600 - Scope of subpart.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Scope of subpart. 217.600 Section 217.600 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Management and...