Sample records for ich draft step

  1. 78 FR 20926 - Draft Guidance for Industry on Providing Postmarket Periodic Safety Reports in the International...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-08

    ...The Food and Drug Administration (FDA) is announcing the availability of a draft guidance for industry entitled ``Providing Postmarket Periodic Safety Reports in the ICH E2C(R2) Format (Periodic Benefit-Risk Evaluation Report).'' This guidance is intended to inform applicants of the conditions under which FDA will exercise its waiver authority to permit applicants to submit an International Conference on Harmonisation (ICH) E2C(R2) Periodic Benefit-Risk Evaluation Report (PBRER) in place of the ICH E2C(R1) Periodic Safety Update Report (PSUR), U.S. periodic adverse drug experience report (PADER), or U.S. periodic adverse experience report (PAER), to satisfy the periodic safety reporting requirements in FDA regulations. The guidance describes the steps applicants can take to submit the PBRER, and discusses the format, content, submission deadline, and frequency of reporting for the PBRER.

  2. ICH S7B draft guideline on the non-clinical strategy for testing delayed cardiac repolarisation risk of drugs: a critical analysis.

    PubMed

    Cavero, Icilio; Crumb, William

    2005-05-01

    The International Conference on Harmonization (ICH) stems from the initiative of three major world partners (Japan, USA, European Community) who composed a mutually accepted body of regulations concerning the safety, quality and efficacy requirements that new medicines have to meet in order to receive market approval. Documents on non-clinical safety pharmacology already composed by this organisation include two guidelines: the S7A adopted in 2000 and, its companion, the S7B guideline, in a draft form since 2001. The S7A guideline deals with general principles and recommendations on safety pharmacology studies designed to protect healthy volunteers and patients from potential drug-induced adverse reactions. The S7B recommends a general non-clinical testing strategy for determining the propensity of non-cardiovascular pharmaceuticals to delay ventricular repolarisation, an effect that at times progresses into life-threatening ventricular arrhythmia. In the most recent version of this document (June 2004), the strategy proposes experimental assays and a critical examination of other pertinent information for applying an 'evidence of risk' label to a compound. Regrettably, the guideline fails to deal satisfactorily with a number of crucial issues such as scoring the evidence of risk and the clinical consequences of such scoring. However, in the latter case, the S7B relies on the new ICH guideline E14 which is currently in preparation. E14 is the clinical counterpart of the S7B guideline which states that non-clinical data are a poor predictor of drug-induced repolarisation delay in humans. The present contribution summarises and assesses salient aspects of the S7A guideline as its founding principles are also applicable to the S7B guideline. The differences in strategies proposed by the various existing drafts of the latter document are critically examined together with some unresolved, crucial problems. The need for extending the objective of the S7B document to

  3. 75 FR 29359 - Draft Environmental Impact Statement for the Tamiami Trail Modifications: Next Steps Project...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-25

    ... Tamiami Trail Modifications: Next Steps Project, Everglades National Park Tamiami Trail Modifications... Interior. ACTION: Notice of availability of the Draft Environmental Impact Statement for the Tamiami Trail... Statement (DEIS) for the Tamiami Trail (U.S. Highway 41) Modifications: Next Steps Project for Everglades...

  4. Tilapia show immunization response against Ich

    USDA-ARS?s Scientific Manuscript database

    This study compares the immune response of Nile tilapia and red tilapia against parasite Ichthyophthirius multifiliis (Ich) using a cohabitation challenge model. Both Nile and red tilapia showed strong immune response post immunization with live Ich theronts by IP injection or immersion. Blood serum...

  5. 76 FR 38187 - International Conference on Harmonisation; Draft Guidance on Q11 Development and Manufacture of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ...The Food and Drug Administration (FDA) is announcing the availability of a draft guidance entitled ``Q11 Development and Manufacture of Drug Substances.'' The draft guidance was prepared under the auspices of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). The draft guidance describes approaches to developing process and drug substance understanding and provides guidance on what information should be provided in certain sections of the Common Technical Document (CTD). The draft guidance is intended to harmonize the scientific and technical principles relating to the description and justification of the development and manufacturing process of drug substances (both chemical entities and biotechnological/biological entities) to enable a consistent approach for providing and evaluating this information across the three regions.

  6. Development of the ITER ICH Transmission Line and Matching System

    NASA Astrophysics Data System (ADS)

    Rasmussen, D. A.; Goulding, R. H.; Pesavento, P. V.; Peters, B.; Swain, D. W.; Fredd, E. H.; Hosea, J.; Greenough, N.

    2011-10-01

    The ITER Ion Cyclotron Heating (ICH) System is designed to couple 20 MW of heating power for ion and electron heating. Prototype components for the ITER Ion Cyclotron Heating (ICH) transmission line and matching system are being designed and tested. The ICH transmission lines are pressurized 300 mm diameter coaxial lines with water-cooled aluminum outer conductor and gas-cooled and water-cooled copper inner conductor. Each ICH transmission line is designed to handle 40-55 MHz power at up to 6 MW/line. A total of 8 lines split to 16 antenna inputs on two ICH antennas. Industrial suppliers have designed coaxial transmission line and matching components and prototypes will be manufactured. The prototype components will be qualified on a test stand operating at the full power and pulse length needed for ITER. The matching system must accommodated dynamic changes in the plasma loading due to ELMS and the L to H-mode transition. Passive ELM tolerance will be performed using hybrid couplers and loads, which can absorb the transient reflected power. The system is also designed to compensate for the mutual inductances of the antenna current straps to limit the peak voltages on the antenna array elements.

  7. 78 FR 22269 - International Conference on Harmonisation; Draft Guidance on M7 Assessment and Control of DNA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    ...The Food and Drug Administration (FDA) is announcing the availability of a draft guidance entitled ``M7 Assessment and Control of DNA Reactive (Mutagenic) Impurities in Pharmaceuticals to Limit Potential Carcinogenic Risk.'' The draft guidance was prepared under the auspices of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). The draft guidance emphasizes considerations of both safety and quality risk management in establishing levels of mutagenic impurities that are expected to pose negligible carcinogenic risk. It outlines recommendations for assessment and control of mutagenic impurities that reside or are reasonably expected to reside in a final drug substance or product, taking into consideration the intended conditions of human use. The draft guidance is intended to provide guidance for new drug substances and new drug products during their clinical development and subsequent applications for marketing.

  8. Recurrence of ICH after resumption of anticoagulation with VK antagonists: CHIRONE study.

    PubMed

    Poli, Daniela; Antonucci, Emilia; Dentali, Francesco; Erba, Nicoletta; Testa, Sophie; Tiraferri, Eros; Palareti, Gualtiero

    2014-03-25

    To evaluate the risk of recurrent intracranial hemorrhage (ICH) in patients on vitamin K antagonists (VKAs) after a first episode of ICH. The Cerebral Haemorrhage in patients Restarting Oral Anticoagulant Therapy (CHIRONE) Study collected data of patients eligible for the study from the database of 27 centers affiliated with the Italian Federation of Anticoagulation Clinics. We enrolled 267 patients (163 male, median age 73.9 years) who had received VKA anticoagulation after an ICH event. During the total period of follow-up (778 patient-years), ICH recurred in 20 patients (7.5%; rate 2.56 × 100 patient-years) at a median time of 16.5 months, and was fatal in 5 patients (25%; rate 0.4 × 100 patient-years). Male sex, hypertension, prosthetic valves, previous ischemic stroke, renal failure, cancer, and spontaneous events were associated with the risk of recurrence, though none of them in isolation reached statistical significance. More than one-third of spontaneous recurrences occurred in patients with a posttraumatic index event. Our results show that patients with a history of ICH carry a significant risk of recurrent ICH when treated with VKA anticoagulation. The risk is also present, though to a lower degree, in patients with previous posttraumatic events. All patients with a history of ICH require a careful evaluation of their thromboembolic risk to estimate the net clinical benefit of (re)starting anticoagulation with VKAs.

  9. Hydrogen inhalation ameliorated mast cell mediated brain injury after ICH in mice

    PubMed Central

    Manaenko, Anatol; Lekic, Tim; Ma, Qingyi; Zhang, John H.; Tang, Jiping

    2012-01-01

    OBJECTIVE Hydrogen inhalation was neuroprotective in several brain injury models. Its mechanisms are believed to be related to anti-oxidative stress. We investigated the potential neurovascular protective effect of hydrogen inhalation especially effect on mast cell activation in a mouse model of intracerebral hemorrhage (ICH). DESIGN Controlled in vivo laboratory study. SETTING Animal research laboratory SUBJECTS 171, 8 weeks old male CD-1 mice were used. INTERVENTIONS Collagenase-induced ICH model in 8 weeks old, male, CD-1 mice was used. Hydrogen was administrated via spontaneous inhalation. The blood-brain barrier (BBB) permeability and neurological deficits were investigated at 24 and 72 hours after ICH. Mast cell activation was evaluated by Western blot and immuno-staining. The effects of hydrogen inhalation on mast cell activation were confirmed in an autologous blood injection model ICH. MEASURMENT AND MAIN RESULTS At 24 and 72 hours post-ICH, animals showed BBB disruption, brain edema, neurological deficits, accompanied with phosphorylation of Lyn kinase and release of tryptase, indicating mast cell activation. Hydrogen treatment diminished phosphorylation of Lyn kinase and release of tryptase, decreased accumulation and degranulation of mast cells, attenuated BBB disruption and improved neurobehavioral function. CONCLUSION Activation of mast cells following ICH contributed to increase of BBB permeability and brain edema. Hydrogen inhalation preserved BBB disruption by prevention of mast cell activation after ICH. PMID:23388512

  10. Ich spreche Deutsch: A User's Report

    ERIC Educational Resources Information Center

    Glassar, Sheila

    1969-01-01

    The textbook under discussion, "Ich spreche Deutsch" by Heinz Griesbach and Dora Schulz (London-Harlow: Longmans-Hueber, 1966), is intended to be a one-year introduction to German, particularly for less academic pupils and students. (FWB)

  11. Interleukin 17A exacerbates ER-stress-mediated inflammation of macrophages following ICH.

    PubMed

    Yang, Zhao; Liu, Qingjun; Shi, Hui; Jiang, Xuheng; Wang, Song; Lu, Yuanlan; Zhang, Ji; Huang, Xiaofei; Yu, Anyong

    2018-05-30

    IL-17A contributes to the initiation of inflammation following intracerebral hemorrhage (ICH). Endoplasmic reticulum (ER) stress acts on protein folding and contributes to inflammatory diseases. The role of IL-17A in the regulation of ER stress following ICH has not been well characterized. In this study, macrophages were stimulated with IL-17A, and then, ER stress and downstream pro-inflammatory factors were measured in vitro. In addition, brain edema and brain injury in ICH mice were assessed in vivo. We demonstrated that IL-17A induced ER stress in macrophages and thus promoted inflammation in vitro. Conversely, IL-17A inhibition attenuated ER stress and neuroinflammation. Furthermore, ERK 1/2 and p38 MAPK pathways mediated IL-17A-induced ER stress in macrophages. We also showed that IL-17A inhibition significantly attenuated ER stress and brain injury in ICH mice. In conclusion, our results demonstrate that IL 17A increases ER stress in macrophages and represents a novel mechanism in ICH. Copyright © 2018. Published by Elsevier Ltd.

  12. Accuracy of professional sports drafts in predicting career potential.

    PubMed

    Koz, D; Fraser-Thomas, J; Baker, J

    2012-08-01

    The forecasting of talented players is a crucial aspect of building a successful sports franchise and professional sports invest significant resources in making player choices in sport drafts. The current study examined the relationship between career performance (i.e. games played) and draft round for the National Football League, National Hockey League, National Basketball League, and Major League Baseball for players drafted from 1980 to 1989 (n = 4874) against the assumption of a linear relationship between performance and draft round (i.e. that players with the most potential will be selected before players of lower potential). A two-step analysis revealed significant differences in games played across draft rounds (step 1) and a significant negative relationship between draft round and games played (step 2); however, the amount of variance accounted for was relatively low (less than 17%). Results highlight the challenges of accurately evaluating amateur talent. © 2011 John Wiley & Sons A/S.

  13. Using a computer model to calculate copper sulfate treatments for Ich

    USDA-ARS?s Scientific Manuscript database

    Copper sulfate (CuSO4) is often used to control infestations of Ichthyophthirius multifiliis (Ich) in pond aquaculture in the United States. In this study, we determined the acute toxicity of CuSO4 to the free-swimming theronts of Ich in reconstituted waters. Water chemistry characteristics, inclu...

  14. Enabling ICH Q10 Implementation--Part 1. Striving for Excellence by Embracing ICH Q8 and ICH Q9.

    PubMed

    Calnan, Nuala; O'Donnell, Kevin; Greene, Anne

    2013-01-01

    This article is the first in a series of articles that will focus on understanding the implementation essentials necessary to deliver operational excellence through a International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) Q10-based pharmaceutical quality system (PQS). The authors examine why, despite the fact that the ICH Q10 guideline has been with us since 2008, the transformation of the traditional Quality Management Systems QMS in use within the pharmaceutical industry is a work in progress for only a few forward-thinking organisations. Unfortunately, this transformation remains a mere aspiration for the majority of organisations. We explore the apparent lack of progress by the pharmaceutical sector in adopting six sigma and related quality management techniques to ensure the availability of high-quality medicines worldwide. The authors propose that the desired progress can be delivered through two key shifts in our current practices; by embodying the principles of operational excellence in every aspect of our business and by learning how to unlock the scientific and tacit knowledge within our organisations. It has been ten years since The Wall Street Journal revealed the pharmaceutical industry's "little secret" comparing the perceived level of manufacturing expertise in the industry as lagging far behind those of potato-chip and laundry-soap makers. Would you consider the quality and manufacturing strategies in place today in your organisation to be more efficient and scientifically based than those of 2003? If so, what evidence exists for you to draw any conclusion regarding enhanced performance? Do your current practices drive innovation and facilitate continual improvement and if so, how? Ultimately, can you confidently affirm that patient-related risks associated with the product(s) manufactured by your organisation have been reduced due to the quality assurance program now applied

  15. Classification of Different Degrees of Disability Following Intracerebral Hemorrhage: A Decision Tree Analysis from VISTA-ICH Collaboration.

    PubMed

    Phan, Thanh G; Chen, Jian; Beare, Richard; Ma, Henry; Clissold, Benjamin; Van Ly, John; Srikanth, Velandai

    2017-01-01

    Prognostication following intracerebral hemorrhage (ICH) has focused on poor outcome at the expense of lumping together mild and moderate disability. We aimed to develop a novel approach at classifying a range of disability following ICH. The Virtual International Stroke Trial Archive collaboration database was searched for patients with ICH and known volume of ICH on baseline CT scans. Disability was partitioned into mild [modified Rankin Scale (mRS) at 90 days of 0-2], moderate (mRS = 3-4), and severe disabilities (mRS = 5-6). We used binary and trichotomy decision tree methodology. The data were randomly divided into training (2/3 of data) and validation (1/3 data) datasets. The area under the receiver operating characteristic curve (AUC) was used to calculate the accuracy of the decision tree model. We identified 957 patients, age 65.9 ± 12.3 years, 63.7% males, and ICH volume 22.6 ± 22.1 ml. The binary tree showed that lower ICH volume (<13.7 ml), age (<66.5 years), serum glucose (<8.95 mmol/l), and systolic blood pressure (<170 mm Hg) discriminate between mild versus moderate-to-severe disabilities with AUC of 0.79 (95% CI 0.73-0.85). Large ICH volume (>27.9 ml), older age (>69.5 years), and low Glasgow Coma Scale (<15) classify severe disability with AUC of 0.80 (95% CI 0.75-0.86). The trichotomy tree showed that ICH volume, age, and serum glucose can separate mild, moderate, and severe disability groups with AUC 0.79 (95% CI 0.71-0.87). Both the binary and trichotomy methods provide equivalent discrimination of disability outcome after ICH. The trichotomy method can classify three categories at once, whereas this action was not possible with the binary method. The trichotomy method may be of use to clinicians and trialists for classifying a range of disability in ICH.

  16. Carbamates and ICH M7 classification: Making use of expert knowledge.

    PubMed

    Hemingway, Rachel; Fowkes, Adrian; Williams, Richard V

    2017-06-01

    Carbamates are widely used in the chemical industry so understanding their toxicity is important to safety assessment. Carbamates have been associated with certain toxicities resulting in publication of structural alerts, including alerts for mutagenicity. Structural alerts for bacterial mutagenicity can be used in combination with statistical systems to enable ICH M7 classification, which allows assessment of the genotoxic risk posed by pharmaceutical impurities. This study tested a hypothetical bacterial mutagenicity alert for carbamates and examined the impact it would have on ICH M7 classifications using (Q)SAR predictions from the expert rule-based system Derek Nexus and the statistical-based system Sarah Nexus. Public datasets have a low prevalence of mutagenic carbamates, which highlighted that systems containing an alert for carbamates perform poorly for achieving correct ICH M7 classifications. Carbamates are commonly used as protecting groups and proprietary datasets containing such compounds were also found to have a low prevalence of mutagenic compounds. Expert review of the mutagenic compounds established that mutagenicity was often only observed under certain (non-standard) conditions and more generally that the Ames test may be a poor predictor for the risk of carcinogenicity posed by chemicals in this class. Overall a structural alert for the in vitro bacterial mutagenesis of carbamates does not benefit workflows for assigning ICH M7 classification to impurities. Crown Copyright © 2017. Published by Elsevier Inc. All rights reserved.

  17. I-Ching, dyadic groups of binary numbers and the geno-logic coding in living bodies.

    PubMed

    Hu, Zhengbing; Petoukhov, Sergey V; Petukhova, Elena S

    2017-12-01

    The ancient Chinese book I-Ching was written a few thousand years ago. It introduces the system of symbols Yin and Yang (equivalents of 0 and 1). It had a powerful impact on culture, medicine and science of ancient China and several other countries. From the modern standpoint, I-Ching declares the importance of dyadic groups of binary numbers for the Nature. The system of I-Ching is represented by the tables with dyadic groups of 4 bigrams, 8 trigrams and 64 hexagrams, which were declared as fundamental archetypes of the Nature. The ancient Chinese did not know about the genetic code of protein sequences of amino acids but this code is organized in accordance with the I-Ching: in particularly, the genetic code is constructed on DNA molecules using 4 nitrogenous bases, 16 doublets, and 64 triplets. The article also describes the usage of dyadic groups as a foundation of the bio-mathematical doctrine of the geno-logic code, which exists in parallel with the known genetic code of amino acids but serves for a different goal: to code the inherited algorithmic processes using the logical holography and the spectral logic of systems of genetic Boolean functions. Some relations of this doctrine with the I-Ching are discussed. In addition, the ratios of musical harmony that can be revealed in the parameters of DNA structure are also represented in the I-Ching book. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. ICH guidelines--implementation of the 3Rs (refinement, reduction, and replacement): incorporating best scientific practices into the regulatory process.

    PubMed

    Ohno, Yasuo

    2002-01-01

    An overview of the International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) is described. ICH was established through cooperation of the regulatory agencies and industrial parties of three main regions involved in pharmaceuticals: the European Union, the United States, and Japan. The purpose of the ICH is to make recommendations to achieve greater harmonization regarding interpretation and application of technical guidelines and requirements for product registration in an effort to reduce or obviate the need to duplicate the testing carried out during the research and development of new medicines. The main purpose of ICH was not to foster the 3Rs per se; however, harmonization of guidelines has eliminated duplications of similar tests to satisfy the specific requirements of each region. The ICH process has contributed to mutual understanding of the regulatory requirements and has decreased the number of unnecessary animal experiments. Specific examples of the contributions of ICH harmonization to the 3Rs are described.

  19. IRIS Toxicological Review for Carbon Tetrachloride (Interagency Science Discussion Draft)

    EPA Science Inventory

    EPA released the draft report,Toxicological Review for Carbon Tetrachloride(Interagency Science Discussion Draft), that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Co...

  20. Hematoma Shape, Hematoma Size, Glasgow Coma Scale Score and ICH Score: Which Predicts the 30-Day Mortality Better for Intracerebral Hematoma?

    PubMed Central

    Wang, Chih-Wei; Liu, Yi-Jui; Lee, Yi-Hsiung; Hueng, Dueng-Yuan; Fan, Hueng-Chuen; Yang, Fu-Chi; Hsueh, Chun-Jen; Kao, Hung-Wen; Juan, Chun-Jung; Hsu, Hsian-He

    2014-01-01

    Purpose To investigate the performance of hematoma shape, hematoma size, Glasgow coma scale (GCS) score, and intracerebral hematoma (ICH) score in predicting the 30-day mortality for ICH patients. To examine the influence of the estimation error of hematoma size on the prediction of 30-day mortality. Materials and Methods This retrospective study, approved by a local institutional review board with written informed consent waived, recruited 106 patients diagnosed as ICH by non-enhanced computed tomography study. The hemorrhagic shape, hematoma size measured by computer-assisted volumetric analysis (CAVA) and estimated by ABC/2 formula, ICH score and GCS score was examined. The predicting performance of 30-day mortality of the aforementioned variables was evaluated. Statistical analysis was performed using Kolmogorov-Smirnov tests, paired t test, nonparametric test, linear regression analysis, and binary logistic regression. The receiver operating characteristics curves were plotted and areas under curve (AUC) were calculated for 30-day mortality. A P value less than 0.05 was considered as statistically significant. Results The overall 30-day mortality rate was 15.1% of ICH patients. The hematoma shape, hematoma size, ICH score, and GCS score all significantly predict the 30-day mortality for ICH patients, with an AUC of 0.692 (P = 0.0018), 0.715 (P = 0.0008) (by ABC/2) to 0.738 (P = 0.0002) (by CAVA), 0.877 (P<0.0001) (by ABC/2) to 0.882 (P<0.0001) (by CAVA), and 0.912 (P<0.0001), respectively. Conclusion Our study shows that hematoma shape, hematoma size, ICH scores and GCS score all significantly predict the 30-day mortality in an increasing order of AUC. The effect of overestimation of hematoma size by ABC/2 formula in predicting the 30-day mortality could be remedied by using ICH score. PMID:25029592

  1. Functional Drafting, Drafting--Intermediate: 9255.02.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    The course consists of six instructional blocks totaling 135 clock hours: (1) functional drafting, (2) threads and fasteners, (3) pictorial drawings, (4) introduction to electronic drafting, (5) introduction to piping drafting, and (6) Quinmester posttest. Mastery of skills indicated in Drafting-Basic--9255.01 is a prerequisite. In the functional…

  2. Drafting Fundamentals. Drafting Module 1. Instructor's Guide.

    ERIC Educational Resources Information Center

    Missouri Univ., Columbia. Instructional Materials Lab.

    This Missouri Vocational Instruction Management System instructor's drafting guide has been keyed to the drafting competency profile developed by state industry and education professionals. The guide contains a cross-reference table of instructional materials. Ten units cover drafting fundamentals: (1) introduction to drafting; (2) general safety;…

  3. Post-operative re-bleeding in patients with hypertensive ICH is closely associated with the CT blend sign.

    PubMed

    Wu, Guofeng; Shen, Zhengkui; Wang, Likun; Sun, Shujie; Luo, Jinbiao; Mao, Yuanhong

    2017-07-06

    Intracranial post-operative re-haemorrhage is an important complication in patients with hypertensive intracerebral haemorrhage (ICH). The purpose of the present study was to determine the value of the computed tomography (CT) blend sign in predicting post-operative re-haemorrhage in patients with ICH. A total of 126 patients with ICH were included in the present study. All the patients underwent standard stereotactic minimally invasive surgery(MIS) to remove the ICH within 24 h following admission. There were 41 patients with a blend sign on initial CT and 85 patients without a blend sign on the initial CT. Multivariable logistic regression analyses were performed to assess the relationship between the presence of the blend sign on the non-enhanced admission CT scan and post-operative re-haemorrhage. Post-operative re-haemorrhage occurred in 24 of the 41 patients with the blend sign, and in 9 of the 85 patients without the blend sign. The incidence of re-haemorrhage was significantly different between the groups. The multivariate logistic regression analysis demonstrated that the initial Glasgow coma scale score (p = 0.002) and blend sign (P < 0.00) on the initial CT scan are independent predictors of post-operative re-haemorrhage. The sensitivity, specificity, and positive and negative predictive values of the blend sign for predicting post-operative re-haemorrhage were 72.7, 81.7, 58.5 and 89.4%, respectively. The presence of the blend sign on the initial CT scan is closely associated with post-operative re-haemorrhage in patients with ICH who undergo stereotactic MIS.

  4. 75 FR 8045 - National Environmental Policy Act (NEPA) Draft Guidance, Establishing, Applying, and Revising...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-23

    ... COUNCIL ON ENVIRONMENTAL QUALITY National Environmental Policy Act (NEPA) Draft Guidance...: Council on Environmental Quality. ACTION: Notice of Availability, Draft Guidance, ``Establishing, Applying... February 18, 2010, the Council on Environmental Quality (CEQ) announced four steps to modernize...

  5. Revision of the ICH guideline on detection of toxicity to reproduction for medicinal products: SWOT analysis.

    PubMed

    Barrow, Paul

    2016-09-01

    SWOT analysis was used to gain insights and perspectives into the revision of the ICH S5(R2) guideline on detection of toxicity to reproduction for medicinal products. The current ICH guideline was rapidly adopted worldwide and has an excellent safety record for more than 20 years. The revised guideline should aim to further improve reproductive and developmental (DART) safety testing for new drugs. Alternative methods to animal experiments should be used whenever possible. Modern technology should be used to obtain high quality data from fewer animals. Additions to the guideline should include considerations on the following: limit dose setting, maternal toxicity, biopharmaceuticals, vaccines, testing strategies by indication, developmental immunotoxicity, and male-mediated developmental toxicity. Emerging issues, such as epigenetics and the microbiome, will most likely pose challenges to DART testing in the future. It is hoped that the new guideline will be adopted even outside the ICH regions. Copyright © 2016 Elsevier Inc. All rights reserved.

  6. ICH: an exclusive club of drug regulatory agencies and drug companies imposing its rules on the rest of the world.

    PubMed

    2010-08-01

    Under the pretext of harmonising regulatory requirements for marketing authorisation of new drugs, the drug regulatory agencies of the world's wealthiest countries and three pharmaceutical industry trade associations, joined together since 1990 in the ICH, are promoting their own interests by imposing their criteria for evaluating drugs on the whole world. The toxicity standards advocated by ICH sometimes promote faster, cheaper drug development over patient protection. The drug quality standards advocated by ICH sometimes increase manufacturing costs without providing any public health benefit. It would be preferable if the World Health Organization were in charge of setting standards for drug development, focusing on patients' interests.

  7. 75 FR 8046 - National Environmental Policy Act (NEPA) Draft Guidance, “NEPA Mitigation and Monitoring.”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-23

    ... COUNCIL ON ENVIRONMENTAL QUALITY National Environmental Policy Act (NEPA) Draft Guidance, ``NEPA Mitigation and Monitoring.'' AGENCY: Council On Environmental Quality. ACTION: Notice of Availability, Draft... Quality (CEQ) announced four steps to modernize, reinvigorate, and ease the use and increase the...

  8. IRIS Toxicological Review of Trichloroethylene (Interagency Science Discussion Draft)

    EPA Science Inventory

    EPA is releasing the draft report, Toxicological Review of Trichloroethylene, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies ...

  9. IRIS Toxicological Review of Hexachloroethane (Interagency Science Consultation Draft)

    EPA Science Inventory

    EPA is releasing the draft report, Toxicological Review of Hexachloroethane, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies a...

  10. IRIS Toxicological Review of Biphenyl (Interagency Science Discussion Draft)

    EPA Science Inventory

    EPA is releasing the draft report, Toxicological Review of Biphenyl, that was distributed to other federal agencies and the Executive Office of the President for comment during Interagency Science Discussion (IASD) (Step 6b) of the IRIS assessment development process. Interagenc...

  11. 46 CFR 97.40-10 - Draft marks and draft indicating systems.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Draft marks and draft indicating systems. 97.40-10... VESSELS OPERATIONS Markings on Vessels § 97.40-10 Draft marks and draft indicating systems. (a) All vessels must have draft marks plainly and legibly visible upon the stem and upon the sternpost or...

  12. 46 CFR 196.40-10 - Draft marks and draft indicating systems.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Draft marks and draft indicating systems. 196.40-10... VESSELS OPERATIONS Markings on Vessels § 196.40-10 Draft marks and draft indicating systems. (a) All vessels must have draft marks plainly and legibly visible upon the stem and upon the sternpost or...

  13. 46 CFR 97.40-10 - Draft marks and draft indicating systems.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Draft marks and draft indicating systems. 97.40-10... VESSELS OPERATIONS Markings on Vessels § 97.40-10 Draft marks and draft indicating systems. (a) All vessels must have draft marks plainly and legibly visible upon the stem and upon the sternpost or...

  14. 46 CFR 97.40-10 - Draft marks and draft indicating systems.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Draft marks and draft indicating systems. 97.40-10... VESSELS OPERATIONS Markings on Vessels § 97.40-10 Draft marks and draft indicating systems. (a) All vessels must have draft marks plainly and legibly visible upon the stem and upon the sternpost or...

  15. 46 CFR 196.40-10 - Draft marks and draft indicating systems.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Draft marks and draft indicating systems. 196.40-10... VESSELS OPERATIONS Markings on Vessels § 196.40-10 Draft marks and draft indicating systems. (a) All vessels must have draft marks plainly and legibly visible upon the stem and upon the sternpost or...

  16. 46 CFR 97.40-10 - Draft marks and draft indicating systems.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Draft marks and draft indicating systems. 97.40-10... VESSELS OPERATIONS Markings on Vessels § 97.40-10 Draft marks and draft indicating systems. (a) All vessels must have draft marks plainly and legibly visible upon the stem and upon the sternpost or...

  17. 46 CFR 196.40-10 - Draft marks and draft indicating systems.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Draft marks and draft indicating systems. 196.40-10... VESSELS OPERATIONS Markings on Vessels § 196.40-10 Draft marks and draft indicating systems. (a) All vessels must have draft marks plainly and legibly visible upon the stem and upon the sternpost or...

  18. 46 CFR 97.40-10 - Draft marks and draft indicating systems.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Draft marks and draft indicating systems. 97.40-10... VESSELS OPERATIONS Markings on Vessels § 97.40-10 Draft marks and draft indicating systems. (a) All vessels must have draft marks plainly and legibly visible upon the stem and upon the sternpost or...

  19. 46 CFR 196.40-10 - Draft marks and draft indicating systems.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Draft marks and draft indicating systems. 196.40-10... VESSELS OPERATIONS Markings on Vessels § 196.40-10 Draft marks and draft indicating systems. (a) All vessels must have draft marks plainly and legibly visible upon the stem and upon the sternpost or...

  20. 46 CFR 196.40-10 - Draft marks and draft indicating systems.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Draft marks and draft indicating systems. 196.40-10... VESSELS OPERATIONS Markings on Vessels § 196.40-10 Draft marks and draft indicating systems. (a) All vessels must have draft marks plainly and legibly visible upon the stem and upon the sternpost or...

  1. 46 CFR 78.50-10 - Draft marks and draft indicating systems.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 3 2013-10-01 2013-10-01 false Draft marks and draft indicating systems. 78.50-10... OPERATIONS Markings on Vessels § 78.50-10 Draft marks and draft indicating systems. (a) All vessels must have draft marks plainly and legibly visible upon the stem and upon the sternpost or rudderpost or any place...

  2. 46 CFR 78.50-10 - Draft marks and draft indicating systems.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 3 2010-10-01 2010-10-01 false Draft marks and draft indicating systems. 78.50-10... OPERATIONS Markings on Vessels § 78.50-10 Draft marks and draft indicating systems. (a) All vessels must have draft marks plainly and legibly visible upon the stem and upon the sternpost or rudderpost or any place...

  3. 46 CFR 78.50-10 - Draft marks and draft indicating systems.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 3 2014-10-01 2014-10-01 false Draft marks and draft indicating systems. 78.50-10... OPERATIONS Markings on Vessels § 78.50-10 Draft marks and draft indicating systems. (a) All vessels must have draft marks plainly and legibly visible upon the stem and upon the sternpost or rudderpost or any place...

  4. 46 CFR 78.50-10 - Draft marks and draft indicating systems.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 3 2012-10-01 2012-10-01 false Draft marks and draft indicating systems. 78.50-10... OPERATIONS Markings on Vessels § 78.50-10 Draft marks and draft indicating systems. (a) All vessels must have draft marks plainly and legibly visible upon the stem and upon the sternpost or rudderpost or any place...

  5. 46 CFR 78.50-10 - Draft marks and draft indicating systems.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 3 2011-10-01 2011-10-01 false Draft marks and draft indicating systems. 78.50-10... OPERATIONS Markings on Vessels § 78.50-10 Draft marks and draft indicating systems. (a) All vessels must have draft marks plainly and legibly visible upon the stem and upon the sternpost or rudderpost or any place...

  6. Anti-epileptic Drug (AED) Use in Subarachnoid Hemorrhage (SAH) and Intracranial Hemorrhage (ICH).

    PubMed

    Feng, Rui; Mascitelli, Justin; Chartrain, Alexander G; Margetis, Konstantinos; Mocco, J

    2017-01-01

    Aneurysmal subarachnoid hemorrhage (aSAH) and spontaneous intracranial hemorrhage (ICH) are frequently associated with epileptic complications. The use of anti-epileptic drugs (AEDs) for seizure prophylaxis, however, is controversial. In patients with aSAH, nonconvulsive status epilepticus has been associated with poor outcome. Effect of other forms of less severe epileptiform activity on clinical outcome remains unclear. Evidence on efficacy of AEDs in reducing seizure incidence is also mixed. However, increasing number of studies suggest that AEDs may have significant adverse effects on outcome, especially with phenytoin. Similarly, in patients with ICH, the impact of seizures that do not progress to status epilepticus on clinical outcome is controversial, and whether prophylactic AED use has independent effects on outcome remains ambiguous. Currently, there are no large scale randomized control trials investigating the efficacy and safety of AED prophylaxis in patients with hemorrhagic stroke. There are also no trials comparing the efficacy and safety of the different AEDs. Survey based studies have found a wide range of prescribing patterns across treatment centers and clinicians for seizure prophylaxis in patients with hemorrhagic stroke. The lack of clear guidelines and recommendations also highlights the paucity of good quality evidence in this area. In conclusion, a well-designed randomized, double blinded, and appropriately powered trial is needed to evaluate the incidence as well as clinical outcomes in patients with aSAH and ICH who received AED prophylaxis versus controls. The results will be extremely valuable in providing evidence to establish management guidelines for patients with hemorrhagic stroke. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  7. IRIS Toxicological Review of Chloroprene (Interagency Science Discussion Draft)

    EPA Science Inventory

    EPA is releasing the draft report, Toxicological Review of Chloroprene, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Co...

  8. IRIS Toxicological Review of Hexachloroethane (Interagency Science Discussion Draft)

    EPA Science Inventory

    EPA is releasing the draft report, Toxicological Review of Hexachloroethane, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Pro...

  9. IRIS Toxicological Review of Pentachlorophenol (Interagency Science Discussion Draft)

    EPA Science Inventory

    EPA is releasing the draft report, Toxicological Review of Pentachlorophenol, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Pr...

  10. IRIS Toxicological Review for Acrylamide (Interagency Science Discussion Draft)

    EPA Science Inventory

    EPA is releasing the draft report, Toxicological Review for Acrylamide, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process<...

  11. IRIS TOXICOLOGICAL REVIEW OF TETRACHLOROETHYLENE (PERCHLOROETHYLENE) (INTERAGENCY SCIENCE DISCUSSION DRAFT)

    EPA Science Inventory

    EPA is releasing the draft report, Toxicological Review of Tetrachloroethylene (Perchloroethylene), that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment...

  12. IRIS Toxicological Review of Urea (Interagency Science Discussion Draft)

    EPA Science Inventory

    EPA is releasing the draft report, Toxicological Review of Urea,, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. C...

  13. Drafting--Basic, Drafting--Intermediate: 9255.01.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    The course has no prerequisites, offers instruction in basic drafting room techniques and procedures, and also covers job opportunities and industrial methods in engineering. The student is introduced to and asked to perform fundamental drafting problems with working drawings, using multiview and auxiliary views and sections. The course also…

  14. Managing Ich infections of walleye cultured in a surface water supply with copper sulfate

    USDA-ARS?s Scientific Manuscript database

    Ichthyophthirius multifiliis infests walleye during growout at Rathbun Fish Hatchery (RFH). Daily flow-through formalin treatments (45-50 ppm for 9 h) were applied to prevent Ich outbreaks, and this contributed to 25% ($35,000) of fish production costs during the grow-out period. Research to decre...

  15. IRIS Toxicological Review of Tetrahydrofuran (THF) (Interagency Science Discussion Draft)

    EPA Science Inventory

    EPA is releasing the draft report, Toxicological Review of Tetrahydrofuran, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Proc...

  16. Computer Assisted Drafting (CNC) Drawings. Drafting Module 6. Instructor's Guide.

    ERIC Educational Resources Information Center

    Missouri Univ., Columbia. Instructional Materials Lab.

    This Missouri Vocational Instruction Management System instructor's drafting guide has been keyed to the drafting competency profile developed by state industry and education professionals. This unit contains information on computer-assisted drafting drawings. The guide contains a cross-reference table of instructional materials and 20 worksheets.…

  17. Influence of I-ching (Yijing, or The Book Of Changes) on Chinese medicine, philosophy and science.

    PubMed

    Lu, Dominic P

    2013-01-01

    I-Ching or Yi-Jing ([see text] also known as The Book of Changes) is the earliest classic in China. It simply explained the formation of the universe and the relationship of man to the universe. Most, if not all, branches of various knowledge, including traditional Chinese medicine, can be traced back its origin to this Book in which Fu Shi ([see text] 2852 B.C.) theorized how the universe was formed, through his keen observation of environment and orbits of sun, moon and stars. He used symbols to represent his views. The essence of I-Ching is basically the expression and function of Yang symbolized as "--" (from <---->) and Yin symbolized "- -" (from --><--), and [see text] Yin and Yang as interaction and circulation of Yang and Yin. Both Yin and Yang were derived from the same origin, Tai-Chi. Fu Shi believed Yin and Yang were the two opposite background force and energy that make the universe as what it is. Yang and Yin manifest in great variety of phenomena such as mind and body, masculine and feminine, sun and moon, hot and cold, heaven and earth, positive and negative electricity etc. The entire theory of Chinese medicine is based on the theories of Yin and Yang as well as that of 5 Element Cycles which are also related to the orderly arrangement of 8 trigrams ([see text]) by King Wen ([see text]1099-1050 B.C.). The 5 Elements Theory explains the "check and balance" mechanism created by the background force of Yin and Yang Qi and illustrated the relationships that are either strengthened or weakened by "acting and controlling" among the 5 elements. I-Ching has exerted profound influences on some well- known European philosophers and scientists, notably Leibnitz and Hegel. Between I-Ching and modern cosmology and the physics of sub-atomic particles, there are some basic theories in common.

  18. 46 CFR 32.05-1 - Draft marks and draft indicating systems-TB/ALL.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Draft marks and draft indicating systems-TB/ALL. 32.05-1..., MACHINERY, AND HULL REQUIREMENTS Markings § 32.05-1 Draft marks and draft indicating systems—TB/ALL. (a) All vessels must have draft marks plainly and legibly visible upon the stem and upon the sternpost or...

  19. 46 CFR 32.05-1 - Draft marks and draft indicating systems-TB/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Draft marks and draft indicating systems-TB/ALL. 32.05-1..., MACHINERY, AND HULL REQUIREMENTS Markings § 32.05-1 Draft marks and draft indicating systems—TB/ALL. (a) All vessels must have draft marks plainly and legibly visible upon the stem and upon the sternpost or...

  20. 46 CFR 32.05-1 - Draft marks and draft indicating systems-TB/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Draft marks and draft indicating systems-TB/ALL. 32.05-1..., MACHINERY, AND HULL REQUIREMENTS Markings § 32.05-1 Draft marks and draft indicating systems—TB/ALL. (a) All vessels must have draft marks plainly and legibly visible upon the stem and upon the sternpost or...

  1. 46 CFR 32.05-1 - Draft marks and draft indicating systems-TB/ALL.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Draft marks and draft indicating systems-TB/ALL. 32.05-1..., MACHINERY, AND HULL REQUIREMENTS Markings § 32.05-1 Draft marks and draft indicating systems—TB/ALL. (a) All vessels must have draft marks plainly and legibly visible upon the stem and upon the sternpost or...

  2. 46 CFR 32.05-1 - Draft marks and draft indicating systems-TB/ALL.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Draft marks and draft indicating systems-TB/ALL. 32.05-1..., MACHINERY, AND HULL REQUIREMENTS Markings § 32.05-1 Draft marks and draft indicating systems—TB/ALL. (a) All vessels must have draft marks plainly and legibly visible upon the stem and upon the sternpost or...

  3. AmeriFlux US-ICh Imnavait Creek Watershed Heath Tundra

    DOE Data Explorer

    Bret-Harte, Syndonia [University of Alaska Fairbanks; Euskirchen, Eugenie [University of Alaska Fairbanks; Shaver, Gaius [Marine Biological Laboratory

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-ICh Imnavait Creek Watershed Heath Tundra. Site Description - The Imnavait Creek Watershed Heath Tundra (Ridge Station) is located near Imnavait Creek in Alaska, north of the Brooks Range in the Kuparuk basin near Lake Toolik and the Toolik Field Station. The Kuparuk River has its headwaters in the Brooks Range and drains through northern Alaska into the Arctic Ocean. Within these headwaters lies the Imnavait basin at an average elevation of 930 m. Water tracks run down the hill in parallel zones with a spacing of approximately 10 m. The Ridge Station was deployed at the end of Summer 2007.

  4. IRIS Toxicological Review of Trichloroacetic Acid (TCA) (Interagency Science Discussion Draft)

    EPA Science Inventory

    EPA is releasing the draft report, Toxicological Review of Trichloroacetic Acid (TCA), that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development ...

  5. 78 FR 74151 - Agency Information Collection Activities; Proposed Collection; Comment Request; Providing Waiver...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-10

    ... Materials in Accordance With Draft Guidance for Industry on Providing Postmarket Periodic Safety Reports in... periodic safety reports as described in the guidance entitled ``Periodic Benefit-Risk Evaluation Report... described in the draft guidance entitled ``Providing Postmarket Periodic Safety Reports in the ICH E2C(R2...

  6. Basic Drafting. Revised.

    ERIC Educational Resources Information Center

    Schertz, Karen

    This introductory module on drafting includes the technical content and tasks necessary for a student to be employed in an entry-level drafting occupation. The module contains 18 instructional units that cover the following topics: introduction to drafting; tools and equipment; supplies and materials; sketching; scales; drawing format; lettering;…

  7. IRIS Toxicological Review of Dichloromethane (Methylene Chloride) (Interagency Science Discussion Draft)

    EPA Science Inventory

    EPA is releasing the draft report, Toxicological Review of Dichloromethane, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Proc...

  8. 46 CFR 167.55-1 - Draft marks and draft indicating systems.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Section 167.55-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS PUBLIC NAUTICAL SCHOOL SHIPS Special Markings Required § 167.55-1 Draft marks and draft indicating systems. (a... are of uniform height equal to the vertical spacing between consecutive marks. (f) Draft marks must be...

  9. 46 CFR 167.55-1 - Draft marks and draft indicating systems.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Section 167.55-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS PUBLIC NAUTICAL SCHOOL SHIPS Special Markings Required § 167.55-1 Draft marks and draft indicating systems. (a... are of uniform height equal to the vertical spacing between consecutive marks. (f) Draft marks must be...

  10. 46 CFR 167.55-1 - Draft marks and draft indicating systems.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Section 167.55-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS PUBLIC NAUTICAL SCHOOL SHIPS Special Markings Required § 167.55-1 Draft marks and draft indicating systems. (a... are of uniform height equal to the vertical spacing between consecutive marks. (f) Draft marks must be...

  11. 46 CFR 167.55-1 - Draft marks and draft indicating systems.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Section 167.55-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS PUBLIC NAUTICAL SCHOOL SHIPS Special Markings Required § 167.55-1 Draft marks and draft indicating systems. (a... are of uniform height equal to the vertical spacing between consecutive marks. (f) Draft marks must be...

  12. 46 CFR 167.55-1 - Draft marks and draft indicating systems.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Section 167.55-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS PUBLIC NAUTICAL SCHOOL SHIPS Special Markings Required § 167.55-1 Draft marks and draft indicating systems. (a... are of uniform height equal to the vertical spacing between consecutive marks. (f) Draft marks must be...

  13. 77 FR 46518 - Draft Resource Management Plan/General Plan Draft Environmental Impact Statement/Revised Draft...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-03

    ... DEPARTMENT OF THE INTERIOR Bureau of Reclamation Draft Resource Management Plan/General Plan Draft... Recreation Area, Merced County, California AGENCY: Bureau of Reclamation, Interior. ACTION: Notice of... California Department of Parks and Recreation was given the responsibility to plan, design, construct...

  14. 46 CFR 131.220 - Drafts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Drafts. 131.220 Section 131.220 Shipping COAST GUARD... Drafts. (a) Each vessel must have the drafts of the vessel plainly and legibly marked upon the stem and... easy observance. The bottom of each mark must indicate the draft. (b) Each draft must be taken from the...

  15. 46 CFR 131.220 - Drafts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Drafts. 131.220 Section 131.220 Shipping COAST GUARD... Drafts. (a) Each vessel must have the drafts of the vessel plainly and legibly marked upon the stem and... easy observance. The bottom of each mark must indicate the draft. (b) Each draft must be taken from the...

  16. 46 CFR 131.220 - Drafts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Drafts. 131.220 Section 131.220 Shipping COAST GUARD... Drafts. (a) Each vessel must have the drafts of the vessel plainly and legibly marked upon the stem and... easy observance. The bottom of each mark must indicate the draft. (b) Each draft must be taken from the...

  17. 46 CFR 131.220 - Drafts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Drafts. 131.220 Section 131.220 Shipping COAST GUARD... Drafts. (a) Each vessel must have the drafts of the vessel plainly and legibly marked upon the stem and... easy observance. The bottom of each mark must indicate the draft. (b) Each draft must be taken from the...

  18. 46 CFR 131.220 - Drafts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Drafts. 131.220 Section 131.220 Shipping COAST GUARD... Drafts. (a) Each vessel must have the drafts of the vessel plainly and legibly marked upon the stem and... easy observance. The bottom of each mark must indicate the draft. (b) Each draft must be taken from the...

  19. Electrical and Electronic Drafting, Drafting 3: 9257.01.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    The course covers the standards used in the electronic field, electrical drawings, electronic drafting, and parts of functional drafting. The student will become familiar with symbols used in these fields and become proficient with tools and reference material used in drawing schematics and mechanical details and in electrical and electronic…

  20. 40 CFR 60.1060 - What steps must I complete for my materials separation plan?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 6 2010-07-01 2010-07-01 false What steps must I complete for my... Requirements: Materials Separation Plan § 60.1060 What steps must I complete for my materials separation plan? (a) For your materials separation plan, you must complete nine steps: (1) Prepare a draft materials...

  1. 76 FR 41808 - Draft Environmental Impact Statement and Draft Habitat Conservation Plan for Oncor Electric...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-15

    ...] Draft Environmental Impact Statement and Draft Habitat Conservation Plan for Oncor Electric Delivery..., announce the availability of the draft environmental impact statement and the draft Oncor Electric Delivery... Oncor Electric Delivery Company, LLC (Applicant; Oncor), and (2) That the Applicant has developed a...

  2. Mechanical Drafting.

    ERIC Educational Resources Information Center

    McClain, Gerald R.

    This publication, the third in a series on drafting, is intended to strengthen students' competence in the specialized field of mechanical drafting. The text consists of instructional materials for both teacher and students, written in terms of student performance using measurable objectives. The course includes 11 units. Each instructional unit…

  3. Architectural Drafting.

    ERIC Educational Resources Information Center

    Davis, Ronald; Yancey, Bruce

    Designed to be used as a supplement to a two-book course in basic drafting, these instructional materials consisting of 14 units cover the process of drawing all working drawings necessary for residential buildings. The following topics are covered in the individual units: introduction to architectural drafting, lettering and tools, site…

  4. 76 FR 59732 - Draft Environmental Impact Statement and Draft Habitat Conservation Plan for Oncor Electric...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-27

    ...] Draft Environmental Impact Statement and Draft Habitat Conservation Plan for Oncor Electric Delivery... availability of the draft environmental impact statement (DEIS) and the draft Oncor Electric Delivery Company... announced that Oncor Electric Delivery Company, LLC, has applied under section 10(a)(1)(B) of the Endangered...

  5. Whole-genome scan identifies quantitative trait loci for chronic pastern dermatitis in German draft horses.

    PubMed

    Mittmann, E Henrike; Mömke, Stefanie; Distl, Ottmar

    2010-02-01

    Chronic pastern dermatitis (CPD), also known as chronic progressive lymphedema (CPL), is a skin disease that affects draft horses. This disease causes painful lower-leg swelling, nodule formation, and skin ulceration, interfering with movement. The aim of this whole-genome scan was to identify quantitative trait loci (QTL) for CPD in German draft horses. We recorded clinical data for CPD in 917 German draft horses and collected blood samples from these horses. Of these 917 horses, 31 paternal half-sib families comprising 378 horses from the breeds Rhenish German, Schleswig, Saxon-Thuringian, and South German were chosen for genotyping. Each half-sib family was constituted by only one draft horse breed. Genotyping was done for 318 polymorphic microsatellites evenly distributed on all equine autosomes and the X chromosome with a mean distance of 7.5 Mb. An across-breed multipoint linkage analysis revealed chromosome-wide significant QTL on horse chromosomes (ECA) 1, 9, 16, and 17. Analyses by breed confirmed the QTL on ECA1 in South German and the QTL on ECA9, 16, and 17 in Saxon-Thuringian draft horses. For the Rhenish German and Schleswig draft horses, additional QTL on ECA4 and 10 and for the South German draft horses an additional QTL on ECA7 were found. This is the first whole-genome scan for CPD in draft horses and it is an important step toward the identification of candidate genes.

  6. General Drafting. Technical Manual.

    ERIC Educational Resources Information Center

    Department of the Army, Washington, DC.

    The manual provides instructional guidance and reference material in the principles and procedures of general drafting and constitutes the primary study text for personnel in drafting as a military occupational specialty. Included is information on drafting equipment and its use; line weights, conventions and formats; lettering; engineering charts…

  7. [Pediatric drug development: ICH harmonized tripartite guideline E11 within the United States of America, the European Union, and Japan].

    PubMed

    Pflieger, M; Bertram, D

    2014-10-01

    To address the lack of appropriate pediatric drugs available on the global market, in 2000 the International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) issued the ICH E11 guideline regarding the Clinical Investigation of Medicinal Products in the Pediatric Population. This guideline considerably changes the environment of drug development for children. It has been written specifically to harmonize, promote, and facilitate high-quality and ethical clinical research for children within the ICH regions, i.e., the United States of America (USA), the European Union (EU), and Japan. This article details the various regulations applicable in each ICH region following the publication of the guideline. The framework of rewards, incentives, and obligations for pharmaceutical companies established for the development of pediatric drugs are compared. It appears that the USA and the EU have both developed specific regulations for pediatric drug development while Japan has not. However, in Japan, pharmaceutical companies (PCs) are encouraged to develop pediatric drugs voluntarily, and they may be granted additional months of market exclusivity or the postponement of the drug re-examination deadline. In both the USA and the EU, regulations aimed to increase the number of clinical studies conducted in children, in order to ensure that the necessary data are generated, determining the conditions in which a drug may be authorized to treat the pediatric population. PCs are encouraged to develop pediatric assessment, including pediatric clinical trials, which is described in a pediatric plan submitted to the relevant authorities. A system of rewards for PCs submitting an application for marketing authorization containing pediatric use information has been put in place to cover the additional investment for testing drugs in children. Subject to conditions, these rewards consist in a 6-month extension of the patent or

  8. 33 CFR 401.29 - Maximum draft.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Maximum draft. 401.29 Section 401... TRANSPORTATION SEAWAY REGULATIONS AND RULES Regulations Seaway Navigation § 401.29 Maximum draft. (a) The draft...) The draft of a vessel shall not, in any case, exceed 79.2 dm or the maximum permissible draft...

  9. 33 CFR 401.29 - Maximum draft.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Maximum draft. 401.29 Section 401... TRANSPORTATION SEAWAY REGULATIONS AND RULES Regulations Seaway Navigation § 401.29 Maximum draft. (a) The draft...) The draft of a vessel shall not, in any case, exceed 79.2 dm or the maximum permissible draft...

  10. 33 CFR 401.29 - Maximum draft.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Maximum draft. 401.29 Section 401... TRANSPORTATION SEAWAY REGULATIONS AND RULES Regulations Seaway Navigation § 401.29 Maximum draft. (a) The draft...) The draft of a vessel shall not, in any case, exceed 79.2 dm or the maximum permissible draft...

  11. Intracerebral hemorrhage (ICH) evaluation with a novel magnetic induction sensor: a preliminary study using the Chinese head model.

    PubMed

    Zhang, Ziyi; Liu, Peiguo; Zhou, Dongming; Zhang, Liang; Lei, Hengdong

    2014-01-01

    Biomedical magnetic induction measurement is a promising method for the detection of intracerebral hemorrhage (ICH), especially in China. Aiming at overcoming the problem of low sensitivity, a magnetic induction sensor is chosen to replace the conventional sensors. It uses a two-arm Archimedean spiral coil as the exciter and a circular coil as the receiver. In order to carry out high-fidelity simulations, the Chinese head model with real anatomical structure is introduced into this novel sensor for the first time. Simulations have been carried out upon early stage ICH measurements. By calculating the state sensitivity and time sensitivity of the perturbation phase of two types of sensors using the electromagnetic software, we conclude that the primary signal received can be largely reduced using the novel sensor, which could effectively increase the time and state sensitivity simultaneously.

  12. Working, Welding and Structural Drafting, Drafting--Intermediate: 9255.03.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    The course introduces the student to working welding drawings, both detail and assembly, as related to all fields of drafting and structural drafting, and provides him with the opportunity to work with various types of tools and equipment. Prior to entry in this course, the vocational student must display mastery of the skills indicated in…

  13. 76 FR 57760 - Notice of Availability of Draft Resource Management Plan and Draft Environmental Impact Statement...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-16

    ... Availability of Draft Resource Management Plan and Draft Environmental Impact Statement for the Colorado River... prepared a Draft Resource Management Plan (RMP) and Draft Environmental Impact Statement (EIS) for the... alternative) seeks to allocate limited resources among competing human interests, land uses, and conservation...

  14. Mississippi Curriculum Framework for Drafting and Design Technology (Program CIP: 48.0102--Architectural Drafting Technology) (Program CIP: 48.0101--General Drafting). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the two course sequences of the state's postsecondary-level drafting and design technology program: architectural drafting technology and drafting and design technology. Presented first are a program description and…

  15. IRIS Toxicological Review of 1,1,2,2-Tetrachloroethane (Interagency Science Discussion Draft)

    EPA Science Inventory

    EPA is releasing the draft report, Toxicological Review of 1,1,2,2-Tetrachloroethane, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Develo...

  16. IRIS Toxicological Review of cis- & trans-1,2-Dichloroethylene (Interagency Science Discussion Draft)

    EPA Science Inventory

    EPA is releasing the draft report, Toxicological Review of cis-1,2-Dichloroethylene and trans-1,2-Dichloroethylene, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Toxicological Review of Hydrogen Cyanide and Cyanide Salts (Interagency Science Discussion Draft)

    EPA Science Inventory

    EPA is releasing the draft report, Toxicological Review of Hydrogen Cyanide (HCN) and Cyanide Salts, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS As...

  17. Drafting: Current Trends and Future Practices

    ERIC Educational Resources Information Center

    Jensen, C.

    1976-01-01

    Various research findings are reported on drafting trends which the author feels should be incorporated into teaching drafting: (1) true position and geometric tolerancing, (2) decimal and metric dimensioning, (3) functional drafting, (4) automated drafting, and (5) drawing reproductions. (BP)

  18. IRIS Toxicological Review of Ethylene Glycol Mono-Butyl Ether (Egbe) (Interagency Science Discussion Draft)

    EPA Science Inventory

    EPA released the draft report, Toxicological Review for Ethylene Glycol Mono-Butyl Ether , that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from ot...

  19. EPA scientific integrity policy draft

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2011-08-01

    The U.S. Environmental Protection Agency (EPA) issued its draft scientific integrity policy on 5 August. The draft policy addresses scientific ethical standards, communications with the public, the use of advisory committees and peer review, and professional development. The draft policy was developed by an ad hoc group of EPA senior staff and scientists in response to a December 2010 memorandum on scientific integrity from the White House Office of Science and Technology Policy. The agency is accepting public comments on the draft through 6 September; comments should be sent to osa.staff@epa.gov. For more information, see http://www.epa.gov/stpc/pdfs/draft-scientific-integrity-policy-aug2011.pdf.

  1. 49 CFR 229.61 - Draft system.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Draft system. 229.61 Section 229.61 Transportation... TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Safety Requirements Draft System § 229.61 Draft system. (a) A... absorbed by friction devices or draft gears that exceeds one-half inches. (5) A broken or cracked coupler...

  2. 49 CFR 229.61 - Draft system.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Draft system. 229.61 Section 229.61 Transportation... TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Safety Requirements Draft System § 229.61 Draft system. (a) A... absorbed by friction devices or draft gears that exceeds one-half inches. (5) A broken or cracked coupler...

  3. 49 CFR 229.61 - Draft system.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Draft system. 229.61 Section 229.61 Transportation... TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Safety Requirements Draft System § 229.61 Draft system. (a) A... absorbed by friction devices or draft gears that exceeds one-half inches. (5) A broken or cracked coupler...

  4. 32 CFR 989.19 - Draft EIS.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 6 2014-07-01 2014-07-01 false Draft EIS. 989.19 Section 989.19 National... ENVIRONMENTAL IMPACT ANALYSIS PROCESS (EIAP) § 989.19 Draft EIS. (a) Preliminary draft. The EPF supports the proponent in preparation of a preliminary draft EIS (PDEIS) (40 CFR 1502.9) based on the scope of issues...

  5. 32 CFR 989.19 - Draft EIS.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 6 2012-07-01 2012-07-01 false Draft EIS. 989.19 Section 989.19 National... ENVIRONMENTAL IMPACT ANALYSIS PROCESS (EIAP) § 989.19 Draft EIS. (a) Preliminary draft. The EPF supports the proponent in preparation of a preliminary draft EIS (PDEIS) (40 CFR 1502.9) based on the scope of issues...

  6. 32 CFR 989.19 - Draft EIS.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Draft EIS. 989.19 Section 989.19 National... ENVIRONMENTAL IMPACT ANALYSIS PROCESS (EIAP) § 989.19 Draft EIS. (a) Preliminary draft. The EPF supports the proponent in preparation of a preliminary draft EIS (PDEIS) (40 CFR 1502.9) based on the scope of issues...

  7. Mechnical Drawing/Drafting Curriculum Guide.

    ERIC Educational Resources Information Center

    Gregory, Margaret R.; Benson, Robert T.

    This curriculum guide consists of materials for teaching a course in mechanical drawing and drafting. Addressed in the individual units of the guide are the following topics: the nature and scope of drawing and drafting, visualization and spatial relationships, drafting tools and materials, linework, freehand lettering, geometric construction,…

  8. 76 FR 57759 - Notice of Availability of Draft Resource Management Plan and Draft Environmental Impact Statement...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-16

    ... Availability of Draft Resource Management Plan and Draft Environmental Impact Statement for the Kremmling Field... Management Act of 1976 (FLPMA), as amended, the Bureau of Land Management (BLM) has prepared a Draft Resource... alternatives for future [[Page 57760

  9. Automatic draft reading based on image processing

    NASA Astrophysics Data System (ADS)

    Tsujii, Takahiro; Yoshida, Hiromi; Iiguni, Youji

    2016-10-01

    In marine transportation, a draft survey is a means to determine the quantity of bulk cargo. Automatic draft reading based on computer image processing has been proposed. However, the conventional draft mark segmentation may fail when the video sequence has many other regions than draft marks and a hull, and the estimated waterline is inherently higher than the true one. To solve these problems, we propose an automatic draft reading method that uses morphological operations to detect draft marks and estimate the waterline for every frame with Canny edge detection and a robust estimation. Moreover, we emulate surveyors' draft reading process for getting the understanding of a shipper and a receiver. In an experiment in a towing tank, the draft reading error of the proposed method was <1 cm, showing the advantage of the proposed method. It is also shown that accurate draft reading has been achieved in a real-world scene.

  10. 78 FR 19733 - Draft General Management Plan and Draft Environmental Impact Statement, Fort Raleigh National...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-02

    ... Management Plan (EIS/GMP) for Fort Raleigh National Historic Site, North Carolina. The draft describes and... announce the dates, times, and locations of public meetings on the draft EIS/GMP through the NPS Planning... delivery to the above address. Electronic copies of the Draft EIS/GMP will be available online at http...

  11. Mathematics for Drafting.

    ERIC Educational Resources Information Center

    Clary, Joseph R.; Nery, Karen P.

    This set of three modules was designed for use primarily to help teach and reinforce the basic mathematics skills in drafting classes. The modules are based on the needs of drafting students in beginning courses as determined by a survey of teachers across North Carolina. Each module consists of basic information and examples and problem sheets…

  12. 75 FR 25856 - Release of Exposure Draft on Definitional Changes Related to Deferred Maintenance and Repairs...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-10

    ... Property, Plant, and Equipment. The proposed Exposure Draft represents a first step toward improving... Related to Deferred Maintenance and Repairs: Amending SFFAS 6, Accounting for Property, Plant, and Equipment AGENCY: Federal Accounting Standards Advisory Board. ACTION: Notice. Board Action: Pursuant to 31...

  13. 10 CFR 51.74 - Distribution of draft environmental impact statement and supplement to draft environmental impact...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Distribution of draft environmental impact statement and supplement to draft environmental impact statement; news releases. 51.74 Section 51.74 Energy NUCLEAR... environmental impact statement; news releases. (a) A copy of the draft environmental impact statement will be...

  14. 10 CFR 51.74 - Distribution of draft environmental impact statement and supplement to draft environmental impact...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Distribution of draft environmental impact statement and supplement to draft environmental impact statement; news releases. 51.74 Section 51.74 Energy NUCLEAR... environmental impact statement; news releases. (a) A copy of the draft environmental impact statement will be...

  15. 10 CFR 51.74 - Distribution of draft environmental impact statement and supplement to draft environmental impact...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Distribution of draft environmental impact statement and supplement to draft environmental impact statement; news releases. 51.74 Section 51.74 Energy NUCLEAR... environmental impact statement; news releases. (a) A copy of the draft environmental impact statement will be...

  16. 10 CFR 51.74 - Distribution of draft environmental impact statement and supplement to draft environmental impact...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Distribution of draft environmental impact statement and supplement to draft environmental impact statement; news releases. 51.74 Section 51.74 Energy NUCLEAR... environmental impact statement; news releases. (a) A copy of the draft environmental impact statement will be...

  17. 10 CFR 51.74 - Distribution of draft environmental impact statement and supplement to draft environmental impact...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Distribution of draft environmental impact statement and supplement to draft environmental impact statement; news releases. 51.74 Section 51.74 Energy NUCLEAR... environmental impact statement; news releases. (a) A copy of the draft environmental impact statement will be...

  18. A comparative study of ICH validated novel spectrophotometric techniques for resolving completely overlapping spectra of quaternary mixtures

    NASA Astrophysics Data System (ADS)

    Ali, Nouruddin W.; Abdelwahab, Nada S.; Abdelkawy, M.; Emam, Aml A.

    2016-02-01

    A pharmaceutically marketed mixture of Yohimbine, Alpha-tocopheryl acetate, Niacin, and Caffeine co-formulated as a promising therapy for erectile dysfunction. Simultaneous determination of the aforementioned pharmaceutical formulation without prior separation steps was applied using mean centering of ratio spectra and triple divisor spectrophotometric methods. Mean centering of ratio spectra method depended on using the mean centered ratio spectra in three successive steps which eliminated the derivative steps and so the signal to noise ratio was improved. The absorption spectra of the prepared solutions were measured in the wavelength range of 215-300 nm in the concentration ranges of 1-15, 3-15, 1-20, and 3-15 μg mL- 1 for Yohimbine, Alpha-tocopheryl acetate, Niacin, and Caffeine, respectively. The amplitudes of the mean centered third ratio spectra were measured at 250 nm and 268 nm for Yohimbine and Alpha-tocopheryl acetate, respectively and at peak to peak 272-273 and 262-263 nm for Niacin and Caffeine, respectively. In triple divisor method each drug in the quaternary mixture was determined by dividing the spectrum of the quaternary mixture by a standard spectrum of a mixture containing equal concentrations of the other three drugs. First derivative of these ratio spectra was obtained where determination could be achieved without any interference from the other three drugs. Amplitudes of 1-15, 3-15, 1-15, and 3-15 μg mL- 1 were used for selective determination of Yohimbine, Alpha-tocopheryl acetate, Niacin, and Caffeine, respectively. Laboratory prepared mixtures were analyzed by the developed novel methods to investigate their selectivity also, Super Act® capsules were successfully analyzed to ensure absence of interference from additives. The developed methods were validated according to the ICH guidelines. The proposed methods were statistically compared with each other and with the reported methods; using student t-test, F-test, and one way ANOVA

  19. A comparative study of ICH validated novel spectrophotometric techniques for resolving completely overlapping spectra of quaternary mixtures.

    PubMed

    Ali, Nouruddin W; Abdelwahab, Nada S; Abdelkawy, M; Emam, Aml A

    2016-02-05

    A pharmaceutically marketed mixture of Yohimbine, Alpha-tocopheryl acetate, Niacin, and Caffeine co-formulated as a promising therapy for erectile dysfunction. Simultaneous determination of the aforementioned pharmaceutical formulation without prior separation steps was applied using mean centering of ratio spectra and triple divisor spectrophotometric methods. Mean centering of ratio spectra method depended on using the mean centered ratio spectra in three successive steps which eliminated the derivative steps and so the signal to noise ratio was improved. The absorption spectra of the prepared solutions were measured in the wavelength range of 215-300 nm in the concentration ranges of 1-15, 3-15, 1-20, and 3-15 μg mL(-1) for Yohimbine, Alpha-tocopheryl acetate, Niacin, and Caffeine, respectively. The amplitudes of the mean centered third ratio spectra were measured at 250 nm and 268 nm for Yohimbine and Alpha-tocopheryl acetate, respectively and at peak to peak 272-273 and 262-263 nm for Niacin and Caffeine, respectively. In triple divisor method each drug in the quaternary mixture was determined by dividing the spectrum of the quaternary mixture by a standard spectrum of a mixture containing equal concentrations of the other three drugs. First derivative of these ratio spectra was obtained where determination could be achieved without any interference from the other three drugs. Amplitudes of 1-15, 3-15, 1-15, and 3-15 μg mL(-1) were used for selective determination of Yohimbine, Alpha-tocopheryl acetate, Niacin, and Caffeine, respectively. Laboratory prepared mixtures were analyzed by the developed novel methods to investigate their selectivity also, Super Act® capsules were successfully analyzed to ensure absence of interference from additives. The developed methods were validated according to the ICH guidelines. The proposed methods were statistically compared with each other and with the reported methods; using student t-test, F-test, and one way ANOVA

  20. Comparison of Conventional and Computer-Aided Drafting Methods from the View of Time and Drafting Quality

    ERIC Educational Resources Information Center

    Ozkan, Aysen; Yildirim, Kemal

    2016-01-01

    Problem Statement: Drafting course is essential for students in the design disciplines for becoming more organized and for complying with standards in the educational system. Drafting knowledge is crucial, both for comprehension of the issues and for the implementation phase. In any design project, drafting performance and success are as important…

  1. Competency Reference for Computer Assisted Drafting.

    ERIC Educational Resources Information Center

    Oregon State Dept. of Education, Salem. Div. of Vocational Technical Education.

    This guide, developed in Oregon, lists competencies essential for students in computer-assisted drafting (CAD). Competencies are organized in eight categories: computer hardware, file usage and manipulation, basic drafting techniques, mechanical drafting, specialty disciplines, three dimensional drawing/design, plotting/printing, and advanced CAD.…

  2. Articulated Instruction Objectives Guide for Drafting. Final Document for Articulation of Drafting.

    ERIC Educational Resources Information Center

    Henderson, Wm. Edward, Jr.

    Intended for use in competency-based and criterion-referenced vocational programs, this articulated, performance-based instruction objectives guide for Drafting I is designed for reference use in the articulation of drafting programs at the secondary and postsecondary levels. It consists of a description of the development of the guide, 14…

  3. 75 FR 55797 - Draft Guidance for Industry on Chronic Hepatitis C Virus Infection: Developing Direct-Acting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-14

    ...] Draft Guidance for Industry on Chronic Hepatitis C Virus Infection: Developing Direct-Acting Antiviral... entitled ``Chronic Hepatitis C Virus Infection: Developing Direct-Acting Antiviral Agents for Treatment... antiviral agents (DAAs), defined as agents that interfere with specific steps in the hepatitis C virus (HCV...

  4. Development of Teaching Material Oxidation-Reduction Reactions through Four Steps Teaching Material Development (4S TMD)

    NASA Astrophysics Data System (ADS)

    Syamsuri, B. S.; Anwar, S.; Sumarna, O.

    2017-09-01

    This research aims to develop oxidation-reduction reactions (redox) teaching material used the Four Steps Teaching Material Development (4S TMD) method consists of four steps: selection, structuring, characterization and didactical reduction. This paper is the first part of the development of teaching material that includes selection and structuring steps. At the selection step, the development of teaching material begins with the development concept of redox based on curriculum demands, then the development of fundamental concepts sourced from the international textbook, and last is the development of values or skills can be integrated with redox concepts. The results of this selection step are the subject matter of the redox concept and values can be integrated with it. In the structuring step was developed concept map that provide on the relationship between redox concepts; Macro structure that guide systematic on the writing of teaching material; And multiple representations which are the development of teaching material that connection between macroscopic, submicroscopic, and symbolic level representations. The result of the two steps in this first part of the study produced a draft of teaching material. Evaluation of the draft of teaching material is done by an expert lecturer in the field of chemical education to assess the feasibility of teaching material.

  5. 78 FR 39253 - Notice of Extension of Comment Period for Draft Initial Comprehensive Plan and Draft...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-01

    ...Pursuant to the Resources and Ecosystems Sustainability, Tourist Opportunities, and Revived Economies of the Gulf States Act (RESTORE Act), the Secretary of Commerce, as Chair of the Gulf Coast Ecosystem Restoration Council (Council), announces the extension of the public comment period for the Draft Initial Comprehensive Plan (Draft Plan) to restore and protect the Gulf Coast region and the Draft Programmatic Environmental Assessment (Draft PEA) for the Draft Plan. Council Members also have compiled preliminary lists of ecosystem restoration projects that are ``authorized but not yet commenced'' and the full Council is in the process of evaluating these lists; the Council announces the availability of these preliminary lists. If you previously submitted comments, please do not resubmit them because the Council has already incorporated them into the public record and will fully consider them.

  6. 46 CFR 151.03-35 - Limiting draft.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Limiting draft. 151.03-35 Section 151.03-35 Shipping... BULK LIQUID HAZARDOUS MATERIAL CARGOES Definitions § 151.03-35 Limiting draft. Maximum allowable draft to which a barge may be loaded. Limiting draft is a function of hull type and cargo specific gravity...

  7. 46 CFR 151.03-35 - Limiting draft.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 5 2012-10-01 2012-10-01 false Limiting draft. 151.03-35 Section 151.03-35 Shipping... BULK LIQUID HAZARDOUS MATERIAL CARGOES Definitions § 151.03-35 Limiting draft. Maximum allowable draft to which a barge may be loaded. Limiting draft is a function of hull type and cargo specific gravity...

  8. 46 CFR 151.03-35 - Limiting draft.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 5 2013-10-01 2013-10-01 false Limiting draft. 151.03-35 Section 151.03-35 Shipping... BULK LIQUID HAZARDOUS MATERIAL CARGOES Definitions § 151.03-35 Limiting draft. Maximum allowable draft to which a barge may be loaded. Limiting draft is a function of hull type and cargo specific gravity...

  9. 46 CFR 151.03-35 - Limiting draft.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 5 2011-10-01 2011-10-01 false Limiting draft. 151.03-35 Section 151.03-35 Shipping... BULK LIQUID HAZARDOUS MATERIAL CARGOES Definitions § 151.03-35 Limiting draft. Maximum allowable draft to which a barge may be loaded. Limiting draft is a function of hull type and cargo specific gravity...

  10. 46 CFR 151.03-35 - Limiting draft.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 5 2014-10-01 2014-10-01 false Limiting draft. 151.03-35 Section 151.03-35 Shipping... BULK LIQUID HAZARDOUS MATERIAL CARGOES Definitions § 151.03-35 Limiting draft. Maximum allowable draft to which a barge may be loaded. Limiting draft is a function of hull type and cargo specific gravity...

  11. 31 CFR 515.406 - Drafts under irrevocable letters of credit; documentary drafts.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Drafts under irrevocable letters of credit; documentary drafts. 515.406 Section 515.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CUBAN ASSETS CONTROL REGULATIONS Interpretations §...

  12. 31 CFR 515.406 - Drafts under irrevocable letters of credit; documentary drafts.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Drafts under irrevocable letters of credit; documentary drafts. 515.406 Section 515.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CUBAN ASSETS CONTROL REGULATIONS Interpretations §...

  13. 31 CFR 515.406 - Drafts under irrevocable letters of credit; documentary drafts.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Drafts under irrevocable letters of credit; documentary drafts. 515.406 Section 515.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CUBAN ASSETS CONTROL REGULATIONS Interpretations §...

  14. 31 CFR 515.406 - Drafts under irrevocable letters of credit; documentary drafts.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Drafts under irrevocable letters of credit; documentary drafts. 515.406 Section 515.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CUBAN ASSETS CONTROL REGULATIONS Interpretations §...

  15. 31 CFR 515.406 - Drafts under irrevocable letters of credit; documentary drafts.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Drafts under irrevocable letters of credit; documentary drafts. 515.406 Section 515.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CUBAN ASSETS CONTROL REGULATIONS Interpretations §...

  16. 31 CFR 500.406 - Drafts under irrevocable letters of credit; documentary drafts.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Drafts under irrevocable letters of credit; documentary drafts. 500.406 Section 500.406 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY FOREIGN ASSETS CONTROL REGULATIONS Interpretations § 50...

  17. A multi-site comparison of in vivo safety pharmacology studies conducted to support ICH S7A & B regulatory submissions.

    PubMed

    Ewart, Lorna; Milne, Aileen; Adkins, Debbie; Benjamin, Amanda; Bialecki, Russell; Chen, Yafei; Ericsson, Ann-Christin; Gardner, Stacey; Grant, Claire; Lengel, David; Lindgren, Silvana; Lowing, Sarah; Marks, Louise; Moors, Jackie; Oldman, Karen; Pietras, Mark; Prior, Helen; Punton, James; Redfern, Will S; Salmond, Ross; Skinner, Matt; Some, Margareta; Stanton, Andrea; Swedberg, Michael; Finch, John; Valentin, Jean-Pierre

    2013-01-01

    Parts A and B of the ICH S7 guidelines on safety pharmacology describe the in vivo studies that must be conducted prior to first time in man administration of any new pharmaceutical. ICH S7A requires a consideration of the sensitivity and reproducibility of the test systems used. This could encompass maintaining a dataset of historical pre-dose values, power analyses, as well as a demonstration of acceptable model sensitivity and robust pharmacological validation. During the process of outsourcing safety pharmacology studies to Charles River Laboratories, AstraZeneca set out to ensure that models were performed identically in each facility and saw this as an opportunity to review the inter-laboratory variability of these essential models. The five in vivo studies outsourced were the conscious dog telemetry model for cardiovascular assessment, the rat whole body plethysmography model for respiratory assessment, the rat modified Irwin screen for central nervous system assessment, the rat charcoal meal study for gastrointestinal assessment and the rat metabolic cage study for assessment of renal function. Each study was validated with known reference compounds and data were compared across facilities. Statistical power was also calculated for each model. The results obtained indicated that each of the studies could be performed with comparable statistical power and could achieve a similar outcome, independent of facility. The consistency of results obtained from these models across multiple facilities was high thus providing confidence that the models can be run in different facilities and maintain compliance with ICH S7A and B. Copyright © 2013 Elsevier Inc. All rights reserved.

  18. 29 CFR 1918.82 - Building drafts.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 7 2011-07-01 2011-07-01 false Building drafts. 1918.82 Section 1918.82 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR LONGSHORING Handling Cargo § 1918.82 Building drafts. (a) Drafts shall...

  19. 29 CFR 1918.82 - Building drafts.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 7 2014-07-01 2014-07-01 false Building drafts. 1918.82 Section 1918.82 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR LONGSHORING Handling Cargo § 1918.82 Building drafts. (a) Drafts shall...

  20. 29 CFR 1918.82 - Building drafts.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 7 2012-07-01 2012-07-01 false Building drafts. 1918.82 Section 1918.82 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR LONGSHORING Handling Cargo § 1918.82 Building drafts. (a) Drafts shall...

  1. 29 CFR 1918.82 - Building drafts.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 7 2013-07-01 2013-07-01 false Building drafts. 1918.82 Section 1918.82 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR LONGSHORING Handling Cargo § 1918.82 Building drafts. (a) Drafts shall...

  2. 33 CFR 401.29 - Maximum draft.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Maximum draft. 401.29 Section 401... TRANSPORTATION SEAWAY REGULATIONS AND RULES Regulations Seaway Navigation § 401.29 Maximum draft. (a) Notwithstanding any provision herein, the loading of cargo, draft and speed of a vessel in transit shall be...

  3. 33 CFR 401.29 - Maximum draft.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Maximum draft. 401.29 Section 401... TRANSPORTATION SEAWAY REGULATIONS AND RULES Regulations Seaway Navigation § 401.29 Maximum draft. (a) Notwithstanding any provision herein, the loading of cargo, draft and speed of a vessel in transit shall be...

  4. Decision for the Draft.

    ERIC Educational Resources Information Center

    Chambers, John Whiteclay, II

    2002-01-01

    Discusses why U.S. President Woodrow Wilson decided to institute the military draft. Provides background information on when Wilson changed from insisting on using volunteers in the military to his resolve for instituting the draft, due to a challenge of power by former U.S. President Theodore Roosevelt. (CMK)

  5. 7 CFR 1488.13 - CCC drafts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false CCC drafts. 1488.13 Section 1488.13 Agriculture... Export Sales of Agricultural Commodities From Private Stocks Under CCC Export Credit Sales Program (GSM-5) Bank Obligations and Repayment § 1488.13 CCC drafts. CCC will draw one draft for each payment due under...

  6. 7 CFR 1488.13 - CCC drafts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false CCC drafts. 1488.13 Section 1488.13 Agriculture... Export Sales of Agricultural Commodities From Private Stocks Under CCC Export Credit Sales Program (GSM-5) Bank Obligations and Repayment § 1488.13 CCC drafts. CCC will draw one draft for each payment due under...

  7. 29 CFR 1918.82 - Building drafts.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 7 2010-07-01 2010-07-01 false Building drafts. 1918.82 Section 1918.82 Labor Regulations...) SAFETY AND HEALTH REGULATIONS FOR LONGSHORING Handling Cargo § 1918.82 Building drafts. (a) Drafts shall be built or means shall be taken to prevent cargo from falling from them. (b) Buckets and tubs used...

  8. 46 CFR 167.65-40 - Draft.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Draft. 167.65-40 Section 167.65-40 Shipping COAST GUARD... Requirements § 167.65-40 Draft. The master of every nautical school ship over 50 gross tons shall, whenever leaving port, enter the maximum draft of his nautical school ship in the log book. ...

  9. 46 CFR 167.65-40 - Draft.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Draft. 167.65-40 Section 167.65-40 Shipping COAST GUARD... Requirements § 167.65-40 Draft. The master of every nautical school ship over 50 gross tons shall, whenever leaving port, enter the maximum draft of his nautical school ship in the log book. ...

  10. 46 CFR 167.65-40 - Draft.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Draft. 167.65-40 Section 167.65-40 Shipping COAST GUARD... Requirements § 167.65-40 Draft. The master of every nautical school ship over 50 gross tons shall, whenever leaving port, enter the maximum draft of his nautical school ship in the log book. ...

  11. 46 CFR 167.65-40 - Draft.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Draft. 167.65-40 Section 167.65-40 Shipping COAST GUARD... Requirements § 167.65-40 Draft. The master of every nautical school ship over 50 gross tons shall, whenever leaving port, enter the maximum draft of his nautical school ship in the log book. ...

  12. 46 CFR 167.65-40 - Draft.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Draft. 167.65-40 Section 167.65-40 Shipping COAST GUARD... Requirements § 167.65-40 Draft. The master of every nautical school ship over 50 gross tons shall, whenever leaving port, enter the maximum draft of his nautical school ship in the log book. ...

  13. 7 CFR 1488.13 - CCC drafts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false CCC drafts. 1488.13 Section 1488.13 Agriculture... Agricultural Commodities From Private Stocks Under CCC Export Credit Sales Program (GSM-5) Bank Obligations and Repayment § 1488.13 CCC drafts. CCC will draw one draft for each payment due under bank obligations. If any...

  14. 7 CFR 1488.13 - CCC drafts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false CCC drafts. 1488.13 Section 1488.13 Agriculture... Agricultural Commodities From Private Stocks Under CCC Export Credit Sales Program (GSM-5) Bank Obligations and Repayment § 1488.13 CCC drafts. CCC will draw one draft for each payment due under bank obligations. If any...

  15. 7 CFR 1488.13 - CCC drafts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false CCC drafts. 1488.13 Section 1488.13 Agriculture... Agricultural Commodities From Private Stocks Under CCC Export Credit Sales Program (GSM-5) Bank Obligations and Repayment § 1488.13 CCC drafts. CCC will draw one draft for each payment due under bank obligations. If any...

  16. Basic Drafting: Book One.

    ERIC Educational Resources Information Center

    Davis, Ronald; And Others

    The first of a two-book course in drafting, this manual consists of 13 topics in the following units: introduction to drafting, general safety, basic tools and lines, major equipment, applying for a job, media, lettering, reproduction, drawing sheet layout, architect's scale usage, civil engineer's scale usage, mechanical engineer's scale usage,…

  17. Predicted percentage dissatisfied with ankle draft.

    PubMed

    Liu, S; Schiavon, S; Kabanshi, A; Nazaroff, W W

    2017-07-01

    Draft is unwanted local convective cooling. The draft risk model of Fanger et al. (Energy and Buildings 12, 21-39, 1988) estimates the percentage of people dissatisfied with air movement due to overcooling at the neck. There is no model for predicting draft at ankles, which is more relevant to stratified air distribution systems such as underfloor air distribution (UFAD) and displacement ventilation (DV). We developed a model for predicted percentage dissatisfied with ankle draft (PPD AD ) based on laboratory experiments with 110 college students. We assessed the effect on ankle draft of various combinations of air speed (nominal range: 0.1-0.6 m/s), temperature (nominal range: 16.5-22.5°C), turbulence intensity (at ankles), sex, and clothing insulation (<0.7 clo; lower legs uncovered and covered). The results show that whole-body thermal sensation and air speed at ankles are the dominant parameters affecting draft. The seated subjects accepted a vertical temperature difference of up to 8°C between ankles (0.1 m) and head (1.1 m) at neutral whole-body thermal sensation, 5°C more than the maximum difference recommended in existing standards. The developed ankle draft model can be implemented in thermal comfort and air diffuser testing standards. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  18. 46 CFR 196.15-5 - Drafts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Drafts. 196.15-5 Section 196.15-5 Shipping COAST GUARD... Inspections § 196.15-5 Drafts. (a) The master of every vessel on an ocean, coastwise, or Great Lakes voyage shall enter the drafts of the vessel, forward and aft, in the official logbook when leaving port. (b) On...

  19. 46 CFR 196.15-5 - Drafts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Drafts. 196.15-5 Section 196.15-5 Shipping COAST GUARD... Inspections § 196.15-5 Drafts. (a) The master of every vessel on an ocean, coastwise, or Great Lakes voyage shall enter the drafts of the vessel, forward and aft, in the official logbook when leaving port. (b) On...

  20. 46 CFR 196.15-5 - Drafts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Drafts. 196.15-5 Section 196.15-5 Shipping COAST GUARD... Inspections § 196.15-5 Drafts. (a) The master of every vessel on an ocean, coastwise, or Great Lakes voyage shall enter the drafts of the vessel, forward and aft, in the official logbook when leaving port. (b) On...

  1. 46 CFR 196.15-5 - Drafts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Drafts. 196.15-5 Section 196.15-5 Shipping COAST GUARD... Inspections § 196.15-5 Drafts. (a) The master of every vessel on an ocean, coastwise, or Great Lakes voyage shall enter the drafts of the vessel, forward and aft, in the official logbook when leaving port. (b) On...

  2. 46 CFR 196.15-5 - Drafts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Drafts. 196.15-5 Section 196.15-5 Shipping COAST GUARD... Inspections § 196.15-5 Drafts. (a) The master of every vessel on an ocean, coastwise, or Great Lakes voyage shall enter the drafts of the vessel, forward and aft, in the official logbook when leaving port. (b) On...

  3. CURRENT PRACTICES OBSERVED IN DESIGN AND DRAFTING OCCUPATIONS.

    ERIC Educational Resources Information Center

    SQUIRES, CARL E.

    DATA WHICH HAD SIGNIFICANCE FOR DESIGN AND DRAFTING CURRICULUMS WERE COLLECTED BY DIRECT OBSERVATION OF 21 DESIGN AND DRAFTING FACTORS WITHIN 16 SELECTED INDUSTRIAL COMPANIES EMPLOYING 869 DESIGNERS AND DRAFTSMEN. OBSERVATIONS COVERED (1) THE NUMBER OF DESIGN AND DRAFTING EMPLOYEES, (2) THE SYSTEM OF DRAFTING ROOM ORGANIZATION, (3) JOB…

  4. Mississippi Curriculum Framework for General Drafting (Program CIP: 48.0101--Drafting, General). Secondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for two secondary-level courses in drafting: drafting I and II. Presented…

  5. Developing and Pretesting a Text Messaging Program for Health Behavior Change: Recommended Steps.

    PubMed

    Abroms, Lorien C; Whittaker, Robyn; Free, Caroline; Mendel Van Alstyne, Judith; Schindler-Ruwisch, Jennifer M

    2015-12-21

    A growing body of evidence demonstrates that text messaging-based programs (short message service [SMS]) on mobile phones can help people modify health behaviors. Most of these programs have consisted of automated and sometimes interactive text messages that guide a person through the process of behavior change. This paper provides guidance on how to develop text messaging programs aimed at changing health behaviors. Based on their collective experience in designing, developing, and evaluating text messaging programs and a review of the literature, the authors drafted the guide. One author initially drafted the guide and the others provided input and review. Steps for developing a text messaging program include conducting formative research for insights into the target audience and health behavior, designing the text messaging program, pretesting the text messaging program concept and messages, and revising the text messaging program. The steps outlined in this guide may help in the development of SMS-based behavior change programs.

  6. Workshop on High Power ICH Antenna Designs for High Density Tokamaks

    NASA Astrophysics Data System (ADS)

    Aamodt, R. E.

    1990-02-01

    A workshop in high power ICH antenna designs for high density tokamaks was held to: (1) review the data base relevant to the high power heating of high density tokamaks; (2) identify the important issues which need to be addressed in order to ensure the success of the ICRF programs on CIT and Alcator C-MOD; and (3) recommend approaches for resolving the issues in a timely realistic manner. Some specific performance goals for the antenna system define a successful design effort. Simply stated these goals are: couple the specified power per antenna into the desired ion species; produce no more than an acceptable level of RF auxiliary power induced impurities; and have a mechanical structure which safely survives the thermal, mechanical and radiation stresses in the relevant environment. These goals are intimately coupled and difficult tradeoffs between scientific and engineering constraints have to be made.

  7. Aeronautical Drafting, Drafting 3: 9257.02.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    Intended for students interested in the aircraft and missile field of engineering and drafting, the course covers fundamentals, working drawings, and auxiliary views and sections that are related to this field. Considered advanced training, a prerequisite for the course is mastery of the skills indicated in Electrical and Electronic…

  8. 76 FR 65744 - Draft Environmental Assessment and Draft Habitat Conservation Plan for Lower Colorado River...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-24

    ...] Draft Environmental Assessment and Draft Habitat Conservation Plan for Lower Colorado River Authority... of availability of documents and announcement of public hearings. SUMMARY: The Lower Colorado River... issuance of an incidental take permit (ITP) to Lower Colorado River Authority Transmission Services...

  9. 76 FR 9345 - Soule Hydro, LLC; Notice of Draft License Application and Preliminary Draft Environmental...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-17

    ...] Soule Hydro, LLC; Notice of Draft License Application and Preliminary Draft Environmental Assessment (PDEA) and Request for Preliminary Terms and Conditions Take notice that the following hydroelectric... Project: With this notice the Commission is soliciting (1) preliminary terms, conditions, and...

  10. Architectural Drafting, Drafting 2: 9255.04.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    The course covers the basic fundamentals of architectural drafting and is not intended to delve into the more advanced phases of architecture. The student is presented with standards and procedures, and will become proficient in layout of floor plans, electrical plans, roof construction, foundation plans, typical wall construction, plot plans, and…

  11. A consortium-driven framework to guide the implementation of ICH M7 Option 4 control strategies.

    PubMed

    Barber, Chris; Antonucci, Vincent; Baumann, Jens-Christoph; Brown, Roland; Covey-Crump, Elizabeth; Elder, David; Elliott, Eric; Fennell, Jared W; Gallou, Fabrice; Ide, Nathan D; Jordine, Guido; Kallemeyn, Jeffrey M; Lauwers, Dirk; Looker, Adam R; Lovelle, Lucie E; McLaughlin, Mark; Molzahn, Robert; Ott, Martin; Schils, Didier; Oestrich, Rolf Schulte; Stevenson, Neil; Talavera, Pere; Teasdale, Andrew; Urquhart, Michael W; Varie, David L; Welch, Dennie

    2017-11-01

    The ICH M7 Option 4 control of (potentially) mutagenic impurities is based on the use of scientific principles in lieu of routine analytical testing. This approach can reduce the burden of analytical testing without compromising patient safety, provided a scientifically rigorous approach is taken which is backed up by sufficient theoretical and/or analytical data. This paper introduces a consortium-led initiative and offers a proposal on the supporting evidence that could be presented in regulatory submissions. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. 76 FR 50490 - Draft Comprehensive Conservation Plan and Draft Environmental Impact Statement, Arctic National...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-15

    ... draft CCP and draft EIS'' in the subject line of the message. Fax: Attn: Sharon Seim, Planning Team Leader, (907) 456-0428. U.S. Mail: Sharon Seim, Planning Team Leader, Arctic National Wildlife Refuge... CONTACT: Sharon Seim, Planning Team Leader, at the address listed above, by phone at (907) 456-0501, or by...

  13. 49 CFR 215.127 - Defective draft arrangement.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Freight Car Components Draft System § 215.127 Defective draft arrangement. A railroad may not place or continue in service a car, if— (a) The car has a draft gear that is inoperative; (b) The car has a broken yoke; (c) An end of car...

  14. 49 CFR 215.127 - Defective draft arrangement.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Freight Car Components Draft System § 215.127 Defective draft arrangement. A railroad may not place or continue in service a car, if— (a) The car has a draft gear that is inoperative; (b) The car has a broken yoke; (c) An end of car...

  15. 49 CFR 215.127 - Defective draft arrangement.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Freight Car Components Draft System § 215.127 Defective draft arrangement. A railroad may not place or continue in service a car, if— (a) The car has a draft gear that is inoperative; (b) The car has a broken yoke; (c) An end of car...

  16. 49 CFR 215.127 - Defective draft arrangement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Freight Car Components Draft System § 215.127 Defective draft arrangement. A railroad may not place or continue in service a car, if— (a) The car has a draft gear that is inoperative; (b) The car has a broken yoke; (c) An end of car...

  17. 49 CFR 215.127 - Defective draft arrangement.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Freight Car Components Draft System § 215.127 Defective draft arrangement. A railroad may not place or continue in service a car, if— (a) The car has a draft gear that is inoperative; (b) The car has a broken yoke; (c) An end of car...

  18. 1 CFR 21.1 - Drafting.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Drafting. 21.1 Section 21.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS PREPARATION OF DOCUMENTS SUBJECT TO CODIFICATION General § 21.1 Drafting. (a) Each agency that prepares a...

  19. 1 CFR 21.1 - Drafting.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Drafting. 21.1 Section 21.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS PREPARATION OF DOCUMENTS SUBJECT TO CODIFICATION General § 21.1 Drafting. (a) Each agency that prepares a...

  20. 1 CFR 21.1 - Drafting.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Drafting. 21.1 Section 21.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS PREPARATION OF DOCUMENTS SUBJECT TO CODIFICATION General § 21.1 Drafting. (a) Each agency that prepares a...

  1. 1 CFR 21.1 - Drafting.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Drafting. 21.1 Section 21.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS PREPARATION OF DOCUMENTS SUBJECT TO CODIFICATION General § 21.1 Drafting. (a) Each agency that prepares a...

  2. 1 CFR 21.1 - Drafting.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Drafting. 21.1 Section 21.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS PREPARATION OF DOCUMENTS SUBJECT TO CODIFICATION General § 21.1 Drafting. (a) Each agency that prepares a...

  3. Positional bias in variant calls against draft reference assemblies.

    PubMed

    Briskine, Roman V; Shimizu, Kentaro K

    2017-03-28

    Whole genome resequencing projects may implement variant calling using draft reference genomes assembled de novo from short-read libraries. Despite lower quality of such assemblies, they allowed researchers to extend a wide range of population genetic and genome-wide association analyses to non-model species. As the variant calling pipelines are complex and involve many software packages, it is important to understand inherent biases and limitations at each step of the analysis. In this article, we report a positional bias present in variant calling performed against draft reference assemblies constructed from de Bruijn or string overlap graphs. We assessed how frequently variants appeared at each position counted from ends of a contig or scaffold sequence, and discovered unexpectedly high number of variants at the positions related to the length of either k-mers or reads used for the assembly. We detected the bias in both publicly available draft assemblies from Assemblathon 2 competition as well as in the assemblies we generated from our simulated short-read data. Simulations confirmed that the bias causing variants are predominantly false positives induced by reads from spatially distant repeated sequences. The bias is particularly strong in contig assemblies. Scaffolding does not eliminate the bias but tends to mitigate it because of the changes in variants' relative positions and alterations in read alignments. The bias can be effectively reduced by filtering out the variants that reside in repetitive elements. Draft genome sequences generated by several popular assemblers appear to be susceptible to the positional bias potentially affecting many resequencing projects in non-model species. The bias is inherent to the assembly algorithms and arises from their particular handling of repeated sequences. It is recommended to reduce the bias by filtering especially if higher-quality genome assembly cannot be achieved. Our findings can help other researchers to

  4. New FDA draft guidance on immunogenicity.

    PubMed

    Parenky, Ashwin; Myler, Heather; Amaravadi, Lakshmi; Bechtold-Peters, Karoline; Rosenberg, Amy; Kirshner, Susan; Quarmby, Valerie

    2014-05-01

    A "Late Breaking" session was held on May 20 at the 2013 American Association of Pharmaceutical Scientists-National Biotech Conference (AAPS-NBC) to discuss the US Food and Drug Administration's (FDA) 2013 draft guidance on Immunogenicity Assessment for Therapeutic Protein Products. The session was initiated by a presentation from the FDA which highlighted several key aspects of the 2013 draft guidance pertaining to immunogenicity risk, the potential impact on patient safety and product efficacy, and risk mitigation. This was followed by an open discussion on the draft guidance which enabled delegates from biopharmaceutical companies to engage the FDA on topics that had emerged from their review of the draft guidance. The multidisciplinary audience fostered an environment that was conducive to scientific discussion on a broad range of topics such as clinical impact, immune mitigation strategies, immune prediction and the role of formulation, excipients, aggregates, and degradation products in immunogenicity. This meeting report highlights several key aspects of the 2013 draft guidance together with related dialog from the session.

  5. IRIS Toxicological Review of Ammonia (Revised External Review Draft)

    EPA Science Inventory

    In August 2013, EPA submitted a revised draft IRIS assessment of ammonia to the agency's Science Advisory Board (SAB) and posted this draft on the IRIS website. EPA had previously released a draft of the assessment for public comment, held a public meeting about the draft, and ...

  6. Teaching Legislative Drafting: A Simulation Approach.

    ERIC Educational Resources Information Center

    Stern, Barry Jeffrey

    1988-01-01

    An approach to teaching legislative drafting uses limited traditional classroom instruction and intensive exposure to the process of legislative drafting through a classroom simulation in which students revise the Massachusetts criminal code. (MSE)

  7. 49 CFR 230.92 - Draw gear and draft systems.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Draw gear and draft systems. 230.92 Section 230.92 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Tenders Draw Gear and Draft Systems § 230.92 Draw gear and draft systems. Couplers, draft gear and...

  8. 49 CFR 230.92 - Draw gear and draft systems.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Draw gear and draft systems. 230.92 Section 230.92 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Tenders Draw Gear and Draft Systems § 230.92 Draw gear and draft systems. Couplers, draft gear and...

  9. 49 CFR 230.92 - Draw gear and draft systems.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Draw gear and draft systems. 230.92 Section 230.92 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Tenders Draw Gear and Draft Systems § 230.92 Draw gear and draft systems. Couplers, draft gear and...

  10. 49 CFR 230.92 - Draw gear and draft systems.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Draw gear and draft systems. 230.92 Section 230.92 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Tenders Draw Gear and Draft Systems § 230.92 Draw gear and draft systems. Couplers, draft gear and...

  11. 49 CFR 230.92 - Draw gear and draft systems.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Draw gear and draft systems. 230.92 Section 230.92 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Tenders Draw Gear and Draft Systems § 230.92 Draw gear and draft systems. Couplers, draft gear and...

  12. Treatment and Outcome of Hemorrhagic Transformation After Intravenous Alteplase in Acute Ischemic Stroke: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association.

    PubMed

    Yaghi, Shadi; Willey, Joshua Z; Cucchiara, Brett; Goldstein, Joshua N; Gonzales, Nicole R; Khatri, Pooja; Kim, Louis J; Mayer, Stephan A; Sheth, Kevin N; Schwamm, Lee H

    2017-12-01

    Symptomatic intracranial hemorrhage (sICH) is the most feared complication of intravenous thrombolytic therapy in acute ischemic stroke. Treatment of sICH is based on expert opinion and small case series, with the efficacy of such treatments not well established. This document aims to provide an overview of sICH with a focus on pathophysiology and treatment. A literature review was performed for randomized trials, prospective and retrospective studies, opinion papers, case series, and case reports on the definitions, epidemiology, risk factors, pathophysiology, treatment, and outcome of sICH. The document sections were divided among writing group members who performed the literature review, summarized the literature, and provided suggestions on the diagnosis and treatment of patients with sICH caused by systemic thrombolysis with alteplase. Several drafts were circulated among writing group members until a consensus was achieved. sICH is an uncommon but severe complication of systemic thrombolysis in acute ischemic stroke. Prompt diagnosis and early correction of the coagulopathy after alteplase have remained the mainstay of treatment. Further research is required to establish treatments aimed at maintaining integrity of the blood-brain barrier in acute ischemic stroke based on inhibition of the underlying biochemical processes. © 2017 American Heart Association, Inc.

  13. 75 FR 3760 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-22

    ... NUCLEAR REGULATORY COMMISSION [NRC-2010-0018] Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory...) is issuing for public comment a draft guide in the agency's ``Regulatory Guide'' series. This series...

  14. 75 FR 20645 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-20

    ... NUCLEAR REGULATORY COMMISSION [NRC-2010-0158] Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory... draft guide in the agency's ``Regulatory Guide'' series. This series was developed to describe and make...

  15. 77 FR 33489 - Draft Offender Tracking System Standard

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-06

    ... Tracking System Standard AGENCY: National Institute of Justice. ACTION: Notice of Draft Offender Tracking System Standard, Selection and Application Guide, and Certification Program Requirements. SUMMARY: In an...) A draft standard entitled, ``Offender Tracking System Standard'' (2) a draft companion document...

  16. Computer Aided Drafting. Instructor's Guide.

    ERIC Educational Resources Information Center

    Henry, Michael A.

    This guide is intended for use in introducing students to the operation and applications of computer-aided drafting (CAD) systems. The following topics are covered in the individual lessons: understanding CAD (CAD versus traditional manual drafting and care of software and hardware); using the components of a CAD system (primary and other input…

  17. 75 FR 18241 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-09

    ... NUCLEAR REGULATORY COMMISSION [NRC-2010-0148] Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory.... Introduction The U.S. Nuclear Regulatory Commission (NRC) is issuing for public comment a draft guide in the...

  18. 75 FR 45166 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-02

    ... NUCLEAR REGULATORY COMMISSION [NRC-2010-0265] Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory.... Introduction The U.S. Nuclear Regulatory Commission (NRC) is issuing for public comment a draft guide in the...

  19. 76 FR 6086 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    ... NUCLEAR REGULATORY COMMISSION 10 CFR Part 73 [NRC-2011-0015] RIN 3150-AI49 Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Availability of Draft... comment Draft Regulatory Guide, DG-5020, ``Applying for Enhanced Weapons Authority, Applying for...

  20. 78 FR 77027 - Overhead Clearance (Air-Draft) Accidents

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-20

    ... No. USCG-2013-0466] Overhead Clearance (Air-Draft) Accidents AGENCY: Coast Guard, DHS. ACTION... clearance (air-draft) accidents. In its petition, which calls for vessel masters to be provided with accurate vertical air draft information, a maritime organization has described 16 overhead clearance...

  1. 76 FR 6085 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    ...-2011-0014] RIN 3150-AI49 Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice Availability of Draft Regulatory Guide. SUMMARY: The U.S. Nuclear Regulatory Commission (Commission or NRC) is issuing for public comment Draft Regulatory Guide, DG-5019, ``Reporting and...

  2. Cluster: Drafting. Course: Architectural Drafting. Research Project.

    ERIC Educational Resources Information Center

    Sanford - Lee County Schools, NC.

    The sequence of 10 units is designed for use with an instructor in architectural drafting, and is also keyed to other texts. Each unit contains several task packages specifying prerequisites, rationale for learning, objectives, learning activities to be supervised by the instructor, and learning practice. The units cover: architectural lettering…

  3. 23 CFR 771.123 - Draft environmental impact statements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 23 Highways 1 2013-04-01 2013-04-01 false Draft environmental impact statements. 771.123 Section... ENVIRONMENT ENVIRONMENTAL IMPACT AND RELATED PROCEDURES § 771.123 Draft environmental impact statements. (a) A draft EIS shall be prepared when the Administration determines that the action is likely to cause...

  4. 23 CFR 771.123 - Draft environmental impact statements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 23 Highways 1 2012-04-01 2012-04-01 false Draft environmental impact statements. 771.123 Section... ENVIRONMENT ENVIRONMENTAL IMPACT AND RELATED PROCEDURES § 771.123 Draft environmental impact statements. (a) A draft EIS shall be prepared when the Administration determines that the action is likely to cause...

  5. 23 CFR 771.123 - Draft environmental impact statements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 23 Highways 1 2014-04-01 2014-04-01 false Draft environmental impact statements. 771.123 Section... ENVIRONMENT ENVIRONMENTAL IMPACT AND RELATED PROCEDURES § 771.123 Draft environmental impact statements. (a) A draft EIS shall be prepared when the Administration determines that the action is likely to cause...

  6. Establishing best practise in the application of expert review of mutagenicity under ICH M7.

    PubMed

    Barber, Chris; Amberg, Alexander; Custer, Laura; Dobo, Krista L; Glowienke, Susanne; Van Gompel, Jacky; Gutsell, Steve; Harvey, Jim; Honma, Masamitsu; Kenyon, Michelle O; Kruhlak, Naomi; Muster, Wolfgang; Stavitskaya, Lidiya; Teasdale, Andrew; Vessey, Jonathan; Wichard, Joerg

    2015-10-01

    The ICH M7 guidelines for the assessment and control of DNA reactive (mutagenic) impurities in pharmaceuticals allows for the consideration of in silico predictions in place of in vitro studies. This represents a significant advance in the acceptance of (Q)SAR models and has resulted from positive interactions between modellers, regulatory agencies and industry with a shared purpose of developing effective processes to minimise risk. This paper discusses key scientific principles that should be applied when evaluating in silico predictions with a focus on accuracy and scientific rigour that will support a consistent and practical route to regulatory submission. Copyright © 2015 Elsevier Inc. All rights reserved.

  7. Safety assessment of biotechnology-derived pharmaceuticals: ICH and beyond.

    PubMed

    Serabian, M A; Pilaro, A M

    1999-01-01

    Many scientific discussions, especially in the past 8 yr, have focused on definition of criteria for the optimal assessment of the preclinical toxicity of pharmaceuticals. With the current overlap of responsibility among centers within the Food and Drug Administration (FDA), uniformity of testing standards, when appropriate, would be desirable. These discussions have extended beyond the boundaries of the FDA and have culminated in the acceptance of formalized, internationally recognized guidances. The work of the International Committee on Harmonisation (ICH) and the initiatives developed by the FDA are important because they (a) represent a consensus scientific opinion, (b) promote consistency, (c) improve the quality of the studies performed, (d) assist the public sector in determining what may be generally acceptable to prepare product development plans, and (e) provide guidance for the sponsors in the design of preclinical toxicity studies. Disadvantages associated with such initiatives include (a) the establishment of a historical database that is difficult to relinquish, (b) the promotion of a check-the-box approach, i.e., a tendancy to perform only the minimum evaluation required by the guidelines, (c) the creation of a disincentive for industry to develop and validate new models, and (d) the creation of state-of-the-art guidances that may not allow for appropriate evaluation of novel therapies. The introduction of biotechnology-derived pharmaceuticals for clinical use has often required the application of unique approaches to assessing their safety in preclinical studies. There is much diversity among these products, which include the gene and cellular therapies, monoclonal antibodies, human-derived recombinant regulatory proteins, blood products, and vaccines. For many of the biological therapies, there will be unique product issues that may require specific modifications to protocol design and may raise additional safety concerns (e.g., immunogenicity

  8. Drafting.

    ERIC Educational Resources Information Center

    Hughes, Larry R.

    This guide to teaching drafting, one in a series of instructional materials for junior high industrial arts education, is designed to assist teachers as they plan and implement new courses of study and as they make revisions and improvements in existing courses in order to integrate classroom learning with real-life experiences. This drafting…

  9. Revision of Electro-Mechanical Drafting Program to Include CAD/D (Computer-Aided Drafting/Design). Final Report.

    ERIC Educational Resources Information Center

    Snyder, Nancy V.

    North Seattle Community College decided to integrate computer-aided design/drafting (CAD/D) into its Electro-Mechanical Drafting Program. This choice necessitated a redefinition of the program through new curriculum and course development. To initiate the project, a new industrial advisory council was formed. Major electronic and recruiting firms…

  10. Automated drafting system uses computer techniques

    NASA Technical Reports Server (NTRS)

    Millenson, D. H.

    1966-01-01

    Automated drafting system produces schematic and block diagrams from the design engineers freehand sketches. This system codes conventional drafting symbols and their coordinate locations on standard size drawings for entry on tapes that are used to drive a high speed photocomposition machine.

  11. Cluster: Drafting. Course: Introduction to Technical Drafting.

    ERIC Educational Resources Information Center

    Sanford - Lee County Schools, NC.

    The set of 10 units is designed for use with an instructor as an introduction to technical drafting, and is also keyed to other texts. Each unit contains several task packages specifying prerequisites, rationale for learning, objectives, learning activities to be supervised by the instructor, and learning practice. The units cover: drafting…

  12. 19 CFR 207.63 - Circulation of draft questionnaires.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 3 2012-04-01 2012-04-01 false Circulation of draft questionnaires. 207.63... SUBSIDIZED EXPORTS TO THE UNITED STATES Five-Year Reviews § 207.63 Circulation of draft questionnaires. (a) The Director shall circulate draft questionnaires to the parties for comment in each full review. (b...

  13. 19 CFR 207.63 - Circulation of draft questionnaires.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 3 2011-04-01 2011-04-01 false Circulation of draft questionnaires. 207.63... SUBSIDIZED EXPORTS TO THE UNITED STATES Five-Year Reviews § 207.63 Circulation of draft questionnaires. (a) The Director shall circulate draft questionnaires to the parties for comment in each full review. (b...

  14. 19 CFR 207.63 - Circulation of draft questionnaires.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 3 2013-04-01 2013-04-01 false Circulation of draft questionnaires. 207.63... SUBSIDIZED EXPORTS TO THE UNITED STATES Five-Year Reviews § 207.63 Circulation of draft questionnaires. (a) The Director shall circulate draft questionnaires to the parties for comment in each full review. (b...

  15. 19 CFR 207.63 - Circulation of draft questionnaires.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 3 2014-04-01 2014-04-01 false Circulation of draft questionnaires. 207.63... SUBSIDIZED EXPORTS TO THE UNITED STATES Five-Year Reviews § 207.63 Circulation of draft questionnaires. (a) The Director shall circulate draft questionnaires to the parties for comment in each full review. (b...

  16. 19 CFR 207.63 - Circulation of draft questionnaires.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Circulation of draft questionnaires. 207.63... SUBSIDIZED EXPORTS TO THE UNITED STATES Five-Year Reviews § 207.63 Circulation of draft questionnaires. (a) The Director shall circulate draft questionnaires to the parties for comment in each full review. (b...

  17. EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments (Volume 1) (Interagency Science Discussion Draft)

    EPA Science Inventory

    EPA is releasing the draft report, EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments (Volume 1), that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the 10 CFR 51.86 - Distribution of draft environmental impact statement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Distribution of draft environmental impact statement. 51...-Regulations Implementing Section 102(2) Draft Environmental Impact Statements-Rulemaking § 51.86 Distribution of draft environmental impact statement. Copies of the draft environmental impact statement and any...

  18. 10 CFR 51.81 - Distribution of draft environmental impact statement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Distribution of draft environmental impact statement. 51...-Regulations Implementing Section 102(2) Draft Environmental Impact Statements-Materials Licenses § 51.81 Distribution of draft environmental impact statement. Copies of the draft environmental impact statement and...

  19. 10 CFR 51.86 - Distribution of draft environmental impact statement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Distribution of draft environmental impact statement. 51...-Regulations Implementing Section 102(2) Draft Environmental Impact Statements-Rulemaking § 51.86 Distribution of draft environmental impact statement. Copies of the draft environmental impact statement and any...

  1. 10 CFR 51.86 - Distribution of draft environmental impact statement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Distribution of draft environmental impact statement. 51...-Regulations Implementing Section 102(2) Draft Environmental Impact Statements-Rulemaking § 51.86 Distribution of draft environmental impact statement. Copies of the draft environmental impact statement and any...

  2. 10 CFR 51.81 - Distribution of draft environmental impact statement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Distribution of draft environmental impact statement. 51...-Regulations Implementing Section 102(2) Draft Environmental Impact Statements-Materials Licenses § 51.81 Distribution of draft environmental impact statement. Copies of the draft environmental impact statement and...

  3. 10 CFR 51.81 - Distribution of draft environmental impact statement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Distribution of draft environmental impact statement. 51...-Regulations Implementing Section 102(2) Draft Environmental Impact Statements-Materials Licenses § 51.81 Distribution of draft environmental impact statement. Copies of the draft environmental impact statement and...

  4. 10 CFR 51.81 - Distribution of draft environmental impact statement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Distribution of draft environmental impact statement. 51...-Regulations Implementing Section 102(2) Draft Environmental Impact Statements-Materials Licenses § 51.81 Distribution of draft environmental impact statement. Copies of the draft environmental impact statement and...

  5. 10 CFR 51.81 - Distribution of draft environmental impact statement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Distribution of draft environmental impact statement. 51...-Regulations Implementing Section 102(2) Draft Environmental Impact Statements-Materials Licenses § 51.81 Distribution of draft environmental impact statement. Copies of the draft environmental impact statement and...

  6. 10 CFR 51.86 - Distribution of draft environmental impact statement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Distribution of draft environmental impact statement. 51...-Regulations Implementing Section 102(2) Draft Environmental Impact Statements-Rulemaking § 51.86 Distribution of draft environmental impact statement. Copies of the draft environmental impact statement and any...

  7. 10 CFR 51.86 - Distribution of draft environmental impact statement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Distribution of draft environmental impact statement. 51...-Regulations Implementing Section 102(2) Draft Environmental Impact Statements-Rulemaking § 51.86 Distribution of draft environmental impact statement. Copies of the draft environmental impact statement and any...

  8. The Physics of Bump Drafting in Car Racing

    ERIC Educational Resources Information Center

    Fiolhais, Miguel C. N.; Amor dos Santos, Susana

    2014-01-01

    The technique of bump drafting, also known as two-car drafting in motorsports, is analysed in the framework of Newtonian mechanics and simple aerodynamic drag forces. As an apparent unnatural effect that often pleases the enthusiasts of car racing, bump drafting provides a unique pedagogical opportunity for students to gain insights into the…

  9. 49 CFR 238.433 - Draft system.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Draft system. 238.433 Section 238.433 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Equipment § 238.433 Draft system. (a) Leading and trailing automatic couplers of trains shall be compatible...

  10. 49 CFR 238.433 - Draft system.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Draft system. 238.433 Section 238.433 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Equipment § 238.433 Draft system. (a) Leading and trailing automatic couplers of trains shall be compatible...

  11. 49 CFR 238.433 - Draft system.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Draft system. 238.433 Section 238.433 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Equipment § 238.433 Draft system. (a) Leading and trailing automatic couplers of trains shall be compatible...

  12. 49 CFR 238.433 - Draft system.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Draft system. 238.433 Section 238.433 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Equipment § 238.433 Draft system. (a) Leading and trailing automatic couplers of trains shall be compatible...

  13. 49 CFR 238.433 - Draft system.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Draft system. 238.433 Section 238.433 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Equipment § 238.433 Draft system. (a) Leading and trailing automatic couplers of trains shall be compatible...

  14. 10 CFR 51.80 - Draft environmental impact statement-materials license.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Draft environmental impact statement-materials license. 51...-Regulations Implementing Section 102(2) Draft Environmental Impact Statements-Materials Licenses § 51.80 Draft environmental impact statement—materials license. (a) The NRC staff will either prepare a draft environmental...

  15. 10 CFR 51.80 - Draft environmental impact statement-materials license.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Draft environmental impact statement-materials license. 51...-Regulations Implementing Section 102(2) Draft Environmental Impact Statements-Materials Licenses § 51.80 Draft environmental impact statement—materials license. (a) The NRC staff will either prepare a draft environmental...

  16. 10 CFR 51.80 - Draft environmental impact statement-materials license.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Draft environmental impact statement-materials license. 51...-Regulations Implementing Section 102(2) Draft Environmental Impact Statements-Materials Licenses § 51.80 Draft environmental impact statement—materials license. (a) The NRC staff will either prepare a draft environmental...

  17. 10 CFR 51.80 - Draft environmental impact statement-materials license.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Draft environmental impact statement-materials license. 51...-Regulations Implementing Section 102(2) Draft Environmental Impact Statements-Materials Licenses § 51.80 Draft environmental impact statement—materials license. (a) The NRC staff will either prepare a draft environmental...

  18. 10 CFR 51.80 - Draft environmental impact statement-materials license.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Draft environmental impact statement-materials license. 51...-Regulations Implementing Section 102(2) Draft Environmental Impact Statements-Materials Licenses § 51.80 Draft environmental impact statement—materials license. (a) The NRC staff will either prepare a draft environmental...

  19. Orientation, Sketching, Mechanical Drawing, Drafting--Basic: 9253.01.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    The course introduces the student to the drafting trade, freehand sketching, and basic mechanical drawing. The course has no prerequisites and will guide the student into drafting concepts and serve as a foundation for further study in vocational drafting. Requiring a total of 45 class hours, eight hours are utilized in orientation, 15 hours are…

  20. 46 CFR 131.510 - Draft and loadline markings.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Draft and loadline markings. 131.510 Section 131.510..., Drills, and Inspections § 131.510 Draft and loadline markings. (a) The master of each vessel on an ocean or coastwise voyage shall enter in the vessel's logbook the drafts of the vessel, forward and aft...

  1. 46 CFR 131.510 - Draft and loadline markings.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Draft and loadline markings. 131.510 Section 131.510..., Drills, and Inspections § 131.510 Draft and loadline markings. (a) The master of each vessel on an ocean or coastwise voyage shall enter in the vessel's logbook the drafts of the vessel, forward and aft...

  2. 46 CFR 131.510 - Draft and loadline markings.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Draft and loadline markings. 131.510 Section 131.510..., Drills, and Inspections § 131.510 Draft and loadline markings. (a) The master of each vessel on an ocean or coastwise voyage shall enter in the vessel's logbook the drafts of the vessel, forward and aft...

  3. 46 CFR 108.661 - Unit markings: Draft marks.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Unit markings: Draft marks. 108.661 Section 108.661... AND EQUIPMENT Equipment Markings and Instructions § 108.661 Unit markings: Draft marks. (a) Each unit must have draft marks for each foot of immersion— (1) If the unit is a surface unit, on both the port...

  4. 46 CFR 108.661 - Unit markings: Draft marks.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Unit markings: Draft marks. 108.661 Section 108.661... AND EQUIPMENT Equipment Markings and Instructions § 108.661 Unit markings: Draft marks. (a) Each unit must have draft marks for each foot of immersion— (1) If the unit is a surface unit, on both the port...

  5. 46 CFR 108.661 - Unit markings: Draft marks.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Unit markings: Draft marks. 108.661 Section 108.661... AND EQUIPMENT Equipment Markings and Instructions § 108.661 Unit markings: Draft marks. (a) Each unit must have draft marks for each foot of immersion— (1) If the unit is a surface unit, on both the port...

  6. 46 CFR 108.661 - Unit markings: Draft marks.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Unit markings: Draft marks. 108.661 Section 108.661... AND EQUIPMENT Equipment Markings and Instructions § 108.661 Unit markings: Draft marks. (a) Each unit must have draft marks for each foot of immersion— (1) If the unit is a surface unit, on both the port...

  7. 46 CFR 108.661 - Unit markings: Draft marks.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Unit markings: Draft marks. 108.661 Section 108.661... AND EQUIPMENT Equipment Markings and Instructions § 108.661 Unit markings: Draft marks. (a) Each unit must have draft marks for each foot of immersion— (1) If the unit is a surface unit, on both the port...

  8. Pipe Drafting with CAD. Teacher Edition.

    ERIC Educational Resources Information Center

    Smithson, Buddy

    This teacher's guide contains nine units of instruction for a course on computer-assisted pipe drafting. The course covers the following topics: introduction to pipe drafting with CAD (computer-assisted design); flow diagrams; pipe and pipe components; valves; piping plans and elevations; isometrics; equipment fabrication drawings; piping design…

  9. 10 CFR 51.85 - Draft environmental impact statement-rulemaking.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Draft environmental impact statement-rulemaking. 51.85... Implementing Section 102(2) Draft Environmental Impact Statements-Rulemaking § 51.85 Draft environmental impact... Commission has determined to prepare an environmental impact statement. ...

  10. 18 CFR 281.212 - Draft tariff and index of entitlements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Draft tariff and index... Rule § 281.212 Draft tariff and index of entitlements. (a) Each interstate pipeline shall prepare draft tariff sheets or sections and a draft index of entitlements in accordance with this subpart. (b) The...

  11. 18 CFR 281.212 - Draft tariff and index of entitlements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Draft tariff and index... Rule § 281.212 Draft tariff and index of entitlements. (a) Each interstate pipeline shall prepare draft tariff sheets or sections and a draft index of entitlements in accordance with this subpart. (b) The...

  12. 18 CFR 281.212 - Draft tariff and index of entitlements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Draft tariff and index... Rule § 281.212 Draft tariff and index of entitlements. (a) Each interstate pipeline shall prepare draft tariff sheets or sections and a draft index of entitlements in accordance with this subpart. (b) The...

  13. 18 CFR 281.212 - Draft tariff and index of entitlements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Draft tariff and index... Rule § 281.212 Draft tariff and index of entitlements. (a) Each interstate pipeline shall prepare draft tariff sheets or sections and a draft index of entitlements in accordance with this subpart. (b) The...

  14. 18 CFR 281.212 - Draft tariff and index of entitlements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Draft tariff and index... Rule § 281.212 Draft tariff and index of entitlements. (a) Each interstate pipeline shall prepare draft tariff sheets or sections and a draft index of entitlements in accordance with this subpart. (b) The...

  15. Assessing risk of draft survey by AHP method

    NASA Astrophysics Data System (ADS)

    Xu, Guangcheng; Zhao, Kuimin; Zuo, Zhaoying; Liu, Gang; Jian, Binguo; Lin, Yan; Fan, Yukun; Wang, Fei

    2018-04-01

    The paper assesses the risks of vessel floating in the seawater for draft survey by using the analytic hierarchy process. On this basis, the paper established draft survey risk index from the view of draft reading, ballast water, fresh water, and calculation process and so on. Then the paper proposes the method to deal with risk assessment using one concrete sample.

  16. Introduction to MacDraft. High-Technology Training Module.

    ERIC Educational Resources Information Center

    Traxler, Gene

    This training module on MacDraft is part of a computer drafting skills unit on communications technology for grades 9-12. The objective is for each student to complete a drawing on the MacIntosh computer using the MacDraft software program. This drawing is to be dimensioned with a dual system and is to include a border and title block. This module…

  17. Socioeconomic Representativeness and the Draft

    DTIC Science & Technology

    1980-06-01

    l that the quality of recruits who enter the services ( especiall the Army) is of lover caliber than historically experienced. Proponents of...the "quality" of recruits who enter the services ( especially the Army) is of lower caliber than historically experienced. Proponents of conscription...draft, especially when considering peacetime conscrip- tion. The strength of the argument for the draft was held to be that all eligible men would serve

  18. Teaching Drafting 101: What Comes First?

    ERIC Educational Resources Information Center

    Carkhuff, Don

    2006-01-01

    Employers require pristine drawings that convey clarity and precision for the production of goods. Can a change in sequence of instruction be expeditious and help teachers better prepare their students for the workplace? Research suggests that combining traditional drafting and computer-aided drafting (CAD) instruction makes sense. It is analogous…

  19. Model Machine Shop for Drafting Instruction.

    ERIC Educational Resources Information Center

    Jackson, Carl R.

    The development and implementation of a two-year interdisciplinary course integrating a machine shop and drafting curriculum are described in the report. The purpose of the course is to provide a learning process in industrial drafting featuring identifiable orientation in skills that will enable the student to develop competencies that are…

  20. 10 CFR 51.85 - Draft environmental impact statement-rulemaking.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Draft environmental impact statement-rulemaking. 51.85 Section 51.85 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR... Implementing Section 102(2) Draft Environmental Impact Statements-Rulemaking § 51.85 Draft environmental impact...

  1. 10 CFR 51.85 - Draft environmental impact statement-rulemaking.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Draft environmental impact statement-rulemaking. 51.85 Section 51.85 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR... Implementing Section 102(2) Draft Environmental Impact Statements-Rulemaking § 51.85 Draft environmental impact...

  2. 10 CFR 51.85 - Draft environmental impact statement-rulemaking.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Draft environmental impact statement-rulemaking. 51.85 Section 51.85 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR... Implementing Section 102(2) Draft Environmental Impact Statements-Rulemaking § 51.85 Draft environmental impact...

  3. 10 CFR 51.85 - Draft environmental impact statement-rulemaking.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Draft environmental impact statement-rulemaking. 51.85 Section 51.85 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR... Implementing Section 102(2) Draft Environmental Impact Statements-Rulemaking § 51.85 Draft environmental impact...

  4. Mechanical Drafting with CAD. Teacher Edition.

    ERIC Educational Resources Information Center

    McClain, Gerald R.

    This instructor's manual contains 13 units of instruction for a course on mechanical drafting with options for using computer-aided drafting (CAD). Each unit includes some or all of the following basic components of a unit of instruction: objective sheet, suggested activities for the teacher, assignment sheets and answers to assignment sheets,…

  5. IRIS Toxicological Review of Trimethylbenzenes (Revised External Review Draft)

    EPA Science Inventory

    In August 2013, EPA submitted a revised draft IRIS assessment of trimethylbenzenes to the agency's Science Advisory Board (SAB) and posted this draft on the IRIS website. EPA had previously released a draft of the assessment for public comment, held a public meeting about the dr...

  6. 10 CFR 51.70 - Draft environmental impact statement-general.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Draft environmental impact statement-general. 51.70... Implementing Section 102(2) Environmental Impact Statements § 51.70 Draft environmental impact statement—general. (a) The NRC staff will prepare a draft environmental impact statement as soon as practicable...

  7. 10 CFR 51.71 - Draft environmental impact statement-contents.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Draft environmental impact statement-contents. 51.71... Implementing Section 102(2) Environmental Impact Statements § 51.71 Draft environmental impact statement—contents. (a) Scope. The draft environmental impact statement will be prepared in accordance with the scope...

  8. 40 CFR 1502.9 - Draft, final, and supplemental statements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 34 2012-07-01 2012-07-01 false Draft, final, and supplemental... IMPACT STATEMENT § 1502.9 Draft, final, and supplemental statements. Except for proposals for legislation... supplemented. (a) Draft environmental impact statements shall be prepared in accordance with the scope decided...

  9. 10 CFR 51.70 - Draft environmental impact statement-general.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Draft environmental impact statement-general. 51.70... Implementing Section 102(2) Environmental Impact Statements § 51.70 Draft environmental impact statement—general. (a) The NRC staff will prepare a draft environmental impact statement as soon as practicable...

  10. 10 CFR 51.70 - Draft environmental impact statement-general.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Draft environmental impact statement-general. 51.70... Implementing Section 102(2) Environmental Impact Statements § 51.70 Draft environmental impact statement—general. (a) The NRC staff will prepare a draft environmental impact statement as soon as practicable...

  11. 10 CFR 51.70 - Draft environmental impact statement-general.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Draft environmental impact statement-general. 51.70... Implementing Section 102(2) Environmental Impact Statements § 51.70 Draft environmental impact statement—general. (a) The NRC staff will prepare a draft environmental impact statement as soon as practicable...

  12. 40 CFR 1502.9 - Draft, final, and supplemental statements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 33 2011-07-01 2011-07-01 false Draft, final, and supplemental... IMPACT STATEMENT § 1502.9 Draft, final, and supplemental statements. Except for proposals for legislation... supplemented. (a) Draft environmental impact statements shall be prepared in accordance with the scope decided...

  13. 10 CFR 51.70 - Draft environmental impact statement-general.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Draft environmental impact statement-general. 51.70... Implementing Section 102(2) Environmental Impact Statements § 51.70 Draft environmental impact statement—general. (a) The NRC staff will prepare a draft environmental impact statement as soon as practicable...

  14. 40 CFR 1502.9 - Draft, final, and supplemental statements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Draft, final, and supplemental... IMPACT STATEMENT § 1502.9 Draft, final, and supplemental statements. Except for proposals for legislation... supplemented. (a) Draft environmental impact statements shall be prepared in accordance with the scope decided...

  15. 40 CFR 1502.9 - Draft, final, and supplemental statements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 33 2014-07-01 2014-07-01 false Draft, final, and supplemental... IMPACT STATEMENT § 1502.9 Draft, final, and supplemental statements. Except for proposals for legislation... supplemented. (a) Draft environmental impact statements shall be prepared in accordance with the scope decided...

  16. 40 CFR 1502.9 - Draft, final, and supplemental statements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 34 2013-07-01 2013-07-01 false Draft, final, and supplemental... IMPACT STATEMENT § 1502.9 Draft, final, and supplemental statements. Except for proposals for legislation... supplemented. (a) Draft environmental impact statements shall be prepared in accordance with the scope decided...

  17. Cluster: Drafting. Course: Basic Technical Drafting. Research Project.

    ERIC Educational Resources Information Center

    Sanford - Lee County Schools, NC.

    The set of six units is designed for use with an instructor in basic technical drafting and is also keyed to other texts. Each unit contains several task packages specifying prerequisites, rationale for learning, objectives, learning activities to be supervised by the instructor, and learning practice. The units cover: pictorial drawing; screw…

  18. 49 CFR 229.61 - Draft system.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... D&E couplers. (2) A crack or break in the side wall or pin bearing bosses outside of the shaded... or draft gears that exceeds one-half inches. (5) A broken or cracked coupler carrier. (6) A broken or cracked yoke. (7) A broken draft gear. (b) A device shall be provided under the lower end of all drawbar...

  19. 49 CFR 229.61 - Draft system.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... D&E couplers. (2) A crack or break in the side wall or pin bearing bosses outside of the shaded... or draft gears that exceeds one-half inches. (5) A broken or cracked coupler carrier. (6) A broken or cracked yoke. (7) A broken draft gear. (b) A device shall be provided under the lower end of all drawbar...

  20. Internal Federal Railroad Administration draft rulemaking document

    DOT National Transportation Integrated Search

    1993-03-08

    THIS DOCUMENT IS A DRAFTOF THE RULE FOR PARTICULAR APPLICABILITY : FOR THE ORLANDO MAGLEV SYSTEM - IT IS STILL A WORKING DRAFT AND : IS BEING DISTRIBUTED SO THAT EVERYONE THAT IS PART OF DRAFTING : THIS RULE CAN HAVE ONE MORE OPPORTUNITY TO REVIEW BO...

  1. 75 FR 21145 - Availability of the Draft Environmental Impact Statement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-22

    ... DEPARTMENT OF TRANSPORTATION Federal Highway Administration Availability of the Draft... availability of the Draft Environmental Impact Statement. SUMMARY: The FHWA, on behalf of the California Department of Transportation (Caltrans), announces the availability of the Draft Environmental Impact...

  2. 46 CFR 32.56-45 - Draft stops-T/ALL.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Draft stops-T/ALL. 32.56-45 Section 32.56-45 Shipping....56-45 Draft stops—T/ALL. (a) Where ceilings or linings are fitted in accommodation, service, or... if draft stops of “B” Class construction are fitted between the ceiling or lining and the deck or...

  3. 46 CFR 32.56-45 - Draft stops-T/ALL.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Draft stops-T/ALL. 32.56-45 Section 32.56-45 Shipping....56-45 Draft stops—T/ALL. (a) Where ceilings or linings are fitted in accommodation, service, or... if draft stops of “B” Class construction are fitted between the ceiling or lining and the deck or...

  4. 46 CFR 32.56-45 - Draft stops-T/ALL.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Draft stops-T/ALL. 32.56-45 Section 32.56-45 Shipping....56-45 Draft stops—T/ALL. (a) Where ceilings or linings are fitted in accommodation, service, or... if draft stops of “B” Class construction are fitted between the ceiling or lining and the deck or...

  5. Managing the Drafting Process: Creating a New Model for the Workplace.

    ERIC Educational Resources Information Center

    Shwom, Barbara L.; Hirsch, Penny L.

    1994-01-01

    Discusses the development of a pragmatic model of the writing process in the workplace, focusing on the importance of "drafting" as part of that process. Discusses writers' attitudes about drafting and the structures of the workplace that drafting has to accommodate. Introduces a drafting model and discusses results of using this model…

  6. 77 FR 27478 - Notice of Availability of the Draft Environmental Impact Statement and Draft Proposed California...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-10

    ...In accordance with the National Environmental Policy Act of 1969, as amended, and the Federal Land Policy and Management Act of 1976, as amended, the Bureau of Land Management (BLM) has prepared a Draft Proposed California Desert Conservation Area (CDCA) Plan Amendment and a Draft Environmental Impact Statement (EIS) for the Haiwee Geothermal Leasing Area (HGLA), Inyo County, California, and by this notice is announcing the opening of the comment period.

  7. IRIS Toxicological Review of Methanol (Noncancer) (Interagency Science Discussion Draft)

    EPA Science Inventory

    On May 3, 2013, the Toxicological Review of Methanol (noncancer) (Revised External Review Draft) was posted for public review and comment. Subsequently, the draft Toxicological Review, Appendices, and draft IRIS Summary were reviewed internally by EPA and by other federal agenci...

  8. 75 FR 48973 - Draft Guidance for Industry: Prevention of Salmonella

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-12

    ...] Draft Guidance for Industry: Prevention of Salmonella Enteritidis in Shell Eggs During Production... entitled ``Prevention of Salmonella Enteritidis in Shell Eggs During Production, Storage, and Transportation'' (the draft guidance). The draft guidance, when finalized, will provide guidance to egg producers...

  9. Normalized Legal Drafting and the Query Method.

    ERIC Educational Resources Information Center

    Allen, Layman E.; Engholm, C. Rudy

    1978-01-01

    Normalized legal drafting, a mode of expressing ideas in legal documents so that the syntax that relates the constituent propositions is simplified and standardized, and the query method, a question-asking activity that teaches normalized drafting and provides practice, are examined. Some examples are presented. (JMD)

  10. In Brief: Geoengineering draft statement

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2009-04-01

    The American Meteorological Society (AMS) has prepared a draft policy statement on geoengineering the climate system, which the AMS Council is considering for approval. The statement notes, “Geoengineering will not substitute for either aggressive mitigation or proactive adaptation. It could contribute to a comprehensive risk management strategy to slow climate change and alleviate its negative impacts, but the potential for adverse and unintended consequences implies a need for adequate research, appropriate regulation, and transparent consideration.” The statement, if adopted, indicates that AMS recommends enhanced research on the scientific and technological potential for geoengineering the climate system; additional study of the historical, ethical, legal, political, and societal aspects of the geoengineering issues; and the development and analysis of policy options to promote transparency and international cooperation in exploring geoengineering options along with restrictions on reckless efforts to manipulate the climate system. AMS is accepting comments on the draft statement until 23 April. For more information, visit http://ametsoc.org/policy/draftstatements/index.html#draft.

  11. Materials and Manufacturing, Drafting 3: 9257.03.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    Designed for students interested in engineering fields pertaining to mechanical and electronic drafting, the course covers several types of drawings in the mechanical and electronic drafting field and many types of machine shop operations. The student will become familiar with stress, loading, safety factors, and manufacturing processes. The…

  12. 10 CFR 51.77 - Distribution of draft environmental impact statement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Distribution of draft environmental impact statement. 51...-Regulations Implementing Section 102(2) Draft Environmental Impact Statements-Production and Utilization Facilities § 51.77 Distribution of draft environmental impact statement. (a) In addition to the distribution...

  13. 10 CFR 51.77 - Distribution of draft environmental impact statement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Distribution of draft environmental impact statement. 51...-Regulations Implementing Section 102(2) Draft Environmental Impact Statements-Production and Utilization Facilities § 51.77 Distribution of draft environmental impact statement. (a) In addition to the distribution...

  14. 10 CFR 51.77 - Distribution of draft environmental impact statement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Distribution of draft environmental impact statement. 51...-Regulations Implementing Section 102(2) Draft Environmental Impact Statements-Production and Utilization Facilities § 51.77 Distribution of draft environmental impact statement. (a) In addition to the distribution...

  15. 77 FR 44610 - Notice of Availability of Draft Environmental Assessment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-30

    .... 12968-001-CT] Notice of Availability of Draft Environmental Assessment FirstLight Hydro Generating...). Staff prepared a draft environmental assessment (EA), which analyzes the potential environmental effects... human environment. A copy of the draft EA is available for review at the Commission in the Public...

  16. 10 CFR 51.77 - Distribution of draft environmental impact statement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Distribution of draft environmental impact statement. 51...-Regulations Implementing Section 102(2) Draft Environmental Impact Statements-Production and Utilization Facilities § 51.77 Distribution of draft environmental impact statement. (a) In addition to the distribution...

  17. 10 CFR 51.77 - Distribution of draft environmental impact statement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Distribution of draft environmental impact statement. 51...-Regulations Implementing Section 102(2) Draft Environmental Impact Statements-Production and Utilization Facilities § 51.77 Distribution of draft environmental impact statement. (a) In addition to the distribution...

  18. 75 FR 22400 - Draft Test Guidelines; Reopening of Comment Period

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-28

    ... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2009-0681; FRL-8822-3] Draft Test Guidelines... draft test guidelines for product performance of public health uses of antimicrobial agents. EPA...-8437-2). In that document, EPA announced the availability of four draft test guidelines for product...

  19. ICH E14 Q & A (R1) document: perspectives on the updated recommendations on thorough QT studies.

    PubMed

    Shah, Rashmi R; Morganroth, Joel

    2013-04-01

    The International Conference on Harmonization (ICH) guidance ICH E14 provides recommendations, focusing on a clinical 'thorough QT/QTc (TQT) study', to evaluate the QT liability of a drug during its development. An Implementation Working Group (IWG) was also established to assist the sponsors with any uncertainties and clarify any ambiguities. In April 2012, the IWG updated its June 2008 version of the Questions and Answers document to address additional issues. These include the gender of the study population, a reasonable approach to evaluating QTc changes in late stage clinical development and the recommended approach to correcting the measured QT interval. This commentary provides our observations and, when appropriate, recommendations, on these issues. We review briefly evidence that suggests that (i) the greater QT effect observed in females is not entirely related to differences in drug exposure and (ii) the Fridericia correction of measured QT interval is adequate for a majority of TQT studies. Until further evidence suggests otherwise, we recommend balanced gender representation in TQT studies, unless warranted otherwise, and for positive studies, subgroup analysis of key data by common demographic variables including the gender and ethnicity. We provide a general scheme for ECG monitoring in late phase clinical trials and consider that while intensive monitoring and centralized reading of ECGs in late phase clinical trials is the norm when a TQT study is positive, there are other circumstances that also call for high quality ECG reading. Therefore, locally read ECGs should only be acceptable as long as accurate high quality ECG data can be guaranteed. © 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society.

  20. Debate on the Draft--Helping Students Decide Where They Stand.

    ERIC Educational Resources Information Center

    Victory, James

    1981-01-01

    Presents four exercises to help secondary school social studies students understand the complex issues of the draft. Students participate in a mock draft lottery, analyze Phil Och's Draft Dodger Rag, examine how individual experiences affect attitudes, and compare writings by Bill Mauldin and Ron Kovic. (KC)

  1. CFD simulation of mechanical draft tube mixing in anaerobic digester tanks.

    PubMed

    Meroney, Robert N; Colorado, P E

    2009-03-01

    Computational Fluid Dynamics (CFD) was used to simulate the mixing characteristics of four different circular anaerobic digester tanks (diameters of 13.7, 21.3, 30.5, and 33.5m) equipped with single and multiple draft impeller tube mixers. Rates of mixing of step and slug injection of tracers were calculated from which digester volume turnover time (DVTT), mixture diffusion time (MDT), and hydraulic retention time (HRT) could be calculated. Washout characteristics were compared to analytic formulae to estimate any presence of partial mixing, dead volume, short-circuiting, or piston flow. CFD satisfactorily predicted performance of both model and full-scale circular tank configurations.

  2. 75 FR 52996 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-30

    ... NUCLEAR REGULATORY COMMISSION [NRC-2010-0287] Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of issuance and availability of Draft Regulatory Guide, DG-8035, ``Administrative Practices in Radiation Surveys and Monitoring.'' FOR FURTHER...

  3. The National Football League Combine: performance differences between drafted and nondrafted players entering the 2004 and 2005 drafts.

    PubMed

    Sierer, S Patrick; Battaglini, Claudio L; Mihalik, Jason P; Shields, Edgar W; Tomasini, Nathan T

    2008-01-01

    The purpose of this study was to examine performance differences between drafted and nondrafted athletes (N = 321) during the 2004 and 2005 National Football League (NFL) Combines. We categorized players into one of 3 groups: Skill, Big skill, and Linemen. Skill players (SP) consisted of wide receivers, cornerbacks, free safeties, strong safeties, and running backs. Big skill players (BSP) included fullbacks, linebackers, tight ends, and defensive ends. Linemen (LM) consisted of centers, offensive guards, offensive tackles, and defensive tackles. We analyzed player height and mass, as well as performance on the following combine drills: 40-yard dash, 225-lb bench press test, vertical jump, broad jump, pro-agility shuttle, and the 3-cone drill. Student t-tests compared performance on each of these measures between drafted and nondrafted players. Statistical significance was found between drafted and nondrafted SP for the 40-yard dash (P < 0.001), vertical jump (P = 0.003), pro-agility shuttle (P < 0.001), and 3-cone drill (P < 0.001). Drafted and nondrafted BSP performed differently on the 40-yard dash (P = 0.002) and 3-cone drill (P = 0.005). Finally, drafted LM performed significantly better than nondrafted LM on the 40-yard dash (P = 0.016), 225-lb bench press (P = 0.003), and 3-cone drill (P = 0.005). Certified strength and conditioning specialists will be able to utilize the significant findings to help better prepare athletes as they ready themselves for the NFL Combine.

  4. 76 FR 26284 - Draft Integrated Science Assessment for Lead (Pb)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-06

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9302-5; Docket ID No. EPA-HQ-ORD-2011-0051] Draft Integrated... the availability of a document titled, ``First External Review Draft Integrated Science Assessment for Lead'' (EPA/600/R-10/075A). This draft document was prepared by the National Center for Environmental...

  5. Computer-Aided Drafting. Education for Technology Employment.

    ERIC Educational Resources Information Center

    Northern Illinois Univ., De Kalb. Dept. of Technology.

    This computer-aided drafting (CAD) curriculum was developed to provide drafting instructors in Illinois with a useful guide for relating an important new technological advance to the vocational classroom. The competency-based learning activity guides are written to be used with any CAD system being used at the secondary and postsecondary levels.…

  6. Reinstate the Draft? Target Report No. 15.

    ERIC Educational Resources Information Center

    Orleans, Bill, Comp.

    Position papers collected by the United States Student Association (USSA) outlining objections to the reimposition of a selective service draft are presented. The USSA believes that a draft is unnecessary because: total active military strength is maintained even when voluntary enlistment falls short of its goal; it would increase military costs;…

  7. 46 CFR 169.755 - Draft marks and draft indicating systems.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Section 169.755 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Vessel Control, Miscellaneous Systems, and Equipment Markings § 169.755 Draft marks and... projections of the marks onto a vertical plane are of uniform height equal to the vertical spacing between...

  8. 46 CFR 169.755 - Draft marks and draft indicating systems.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Section 169.755 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Vessel Control, Miscellaneous Systems, and Equipment Markings § 169.755 Draft marks and... projections of the marks onto a vertical plane are of uniform height equal to the vertical spacing between...

  9. 46 CFR 169.755 - Draft marks and draft indicating systems.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Section 169.755 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Vessel Control, Miscellaneous Systems, and Equipment Markings § 169.755 Draft marks and... projections of the marks onto a vertical plane are of uniform height equal to the vertical spacing between...

  10. 46 CFR 169.755 - Draft marks and draft indicating systems.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Section 169.755 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Vessel Control, Miscellaneous Systems, and Equipment Markings § 169.755 Draft marks and... projections of the marks onto a vertical plane are of uniform height equal to the vertical spacing between...

  11. 46 CFR 169.755 - Draft marks and draft indicating systems.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Section 169.755 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Vessel Control, Miscellaneous Systems, and Equipment Markings § 169.755 Draft marks and... projections of the marks onto a vertical plane are of uniform height equal to the vertical spacing between...

  12. 10 CFR 51.72 - Supplement to draft environmental impact statement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Supplement to draft environmental impact statement. 51.72... Implementing Section 102(2) Environmental Impact Statements § 51.72 Supplement to draft environmental impact statement. (a) The NRC staff will prepare a supplement to a draft environmental impact statement for which a...

  13. 10 CFR 51.72 - Supplement to draft environmental impact statement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Supplement to draft environmental impact statement. 51.72... Implementing Section 102(2) Environmental Impact Statements § 51.72 Supplement to draft environmental impact statement. (a) The NRC staff will prepare a supplement to a draft environmental impact statement for which a...

  14. 18 CFR 5.25 - Applications requiring a draft NEPA document.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... a draft NEPA document. 5.25 Section 5.25 Conservation of Power and Water Resources FEDERAL ENERGY... APPLICATION PROCESS § 5.25 Applications requiring a draft NEPA document. (a) If the Commission determines that a license application will be processed with an environmental impact statement, or a draft and final...

  15. 10 CFR 51.72 - Supplement to draft environmental impact statement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Supplement to draft environmental impact statement. 51.72... Implementing Section 102(2) Environmental Impact Statements § 51.72 Supplement to draft environmental impact statement. (a) The NRC staff will prepare a supplement to a draft environmental impact statement for which a...

  16. 10 CFR 51.72 - Supplement to draft environmental impact statement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Supplement to draft environmental impact statement. 51.72... Implementing Section 102(2) Environmental Impact Statements § 51.72 Supplement to draft environmental impact statement. (a) The NRC staff will prepare a supplement to a draft environmental impact statement for which a...

  17. 18 CFR 5.25 - Applications requiring a draft NEPA document.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... a draft NEPA document. 5.25 Section 5.25 Conservation of Power and Water Resources FEDERAL ENERGY... APPLICATION PROCESS § 5.25 Applications requiring a draft NEPA document. (a) If the Commission determines that a license application will be processed with an environmental impact statement, or a draft and final...

  18. 18 CFR 5.25 - Applications requiring a draft NEPA document.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... a draft NEPA document. 5.25 Section 5.25 Conservation of Power and Water Resources FEDERAL ENERGY... APPLICATION PROCESS § 5.25 Applications requiring a draft NEPA document. (a) If the Commission determines that a license application will be processed with an environmental impact statement, or a draft and final...

  19. 10 CFR 51.72 - Supplement to draft environmental impact statement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Supplement to draft environmental impact statement. 51.72... Implementing Section 102(2) Environmental Impact Statements § 51.72 Supplement to draft environmental impact statement. (a) The NRC staff will prepare a supplement to a draft environmental impact statement for which a...

  20. 76 FR 32878 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-07

    ...-0129] Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory Guide, DG-1253, ``Preoperational Testing of Emergency Core Cooling Systems for Pressurized-Water Reactors''. FOR FURTHER INFORMATION CONTACT: Mekonen M...

  1. Multi-Draft Composing: An Iterative Model for Academic Argument Writing

    ERIC Educational Resources Information Center

    Eckstein, Grant; Chariton, Jessica; McCollum, Robb Mark

    2011-01-01

    Post-secondary writing teachers in composition and English as a second language (ESL) writing programs are likely familiar with multi-draft composing. Both composition and ESL writing programs share nearly identical multi-draft models despite the very unique and different cultures of each group. We argue that multi-draft composing as it is…

  2. 31 CFR 515.531 - Payment of certain checks and drafts.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Payment of certain checks and drafts... Licenses, Authorizations, and Statements of Licensing Policy § 515.531 Payment of certain checks and drafts... blocked accounts with such banking institution: (1) Of checks and drafts drawn or issued prior to the...

  3. 31 CFR 535.531 - Payment of certain checks and drafts.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Payment of certain checks and drafts... Licenses, Authorizations and Statements of Licensing Policy § 535.531 Payment of certain checks and drafts... from blocked accounts with such banking institution of checks and drafts drawn or issued prior to the...

  4. 31 CFR 535.531 - Payment of certain checks and drafts.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Payment of certain checks and drafts... Licenses, Authorizations and Statements of Licensing Policy § 535.531 Payment of certain checks and drafts... from blocked accounts with such banking institution of checks and drafts drawn or issued prior to the...

  5. 31 CFR 515.531 - Payment of certain checks and drafts.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Payment of certain checks and drafts... Licenses, Authorizations, and Statements of Licensing Policy § 515.531 Payment of certain checks and drafts... blocked accounts with such banking institution: (1) Of checks and drafts drawn or issued prior to the...

  6. 31 CFR 515.531 - Payment of certain checks and drafts.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Payment of certain checks and drafts... Licenses, Authorizations, and Statements of Licensing Policy § 515.531 Payment of certain checks and drafts... blocked accounts with such banking institution: (1) Of checks and drafts drawn or issued prior to the...

  7. 31 CFR 535.531 - Payment of certain checks and drafts.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Payment of certain checks and drafts... Licenses, Authorizations and Statements of Licensing Policy § 535.531 Payment of certain checks and drafts... from blocked accounts with such banking institution of checks and drafts drawn or issued prior to the...

  8. 31 CFR 535.531 - Payment of certain checks and drafts.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Payment of certain checks and drafts... Licenses, Authorizations and Statements of Licensing Policy § 535.531 Payment of certain checks and drafts... from blocked accounts with such banking institution of checks and drafts drawn or issued prior to the...

  9. 31 CFR 515.531 - Payment of certain checks and drafts.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Payment of certain checks and drafts... Licenses, Authorizations, and Statements of Licensing Policy § 515.531 Payment of certain checks and drafts... blocked accounts with such banking institution: (1) Of checks and drafts drawn or issued prior to the...

  10. Flow characteristics of an inclined air-curtain range hood in a draft

    PubMed Central

    CHEN, Jia-Kun

    2015-01-01

    The inclined air-curtain technology was applied to build an inclined air-curtain range hood. A draft generator was applied to affect the inclined air-curtain range hood in three directions: lateral (θ=0°), oblique (θ=45°), and front (θ=90°). The three suction flow rates provided by the inclined air-curtain range hood were 10.1, 10.9, and 12.6 m3/min. The laser-assisted flow visualization technique and the tracer-gas test method were used to investigate the performance of the range hood under the influence of a draft. The results show that the inclined air-curtain range hood has a strong ability to resist the negative effect of a front draft until the draft velocity is greater than 0.5 m/s. The oblique draft affected the containment ability of the inclined air-curtain range hood when the draft velocity was larger than 0.3 m/s. When the lateral draft effect was applied, the capture efficiency of the inclined air-curtain range hood decreased quickly in the draft velocity from 0.2 m/s to 0.3 m/s. However, the capture efficiencies of the inclined air-curtain range hood under the influence of the front draft were higher than those under the influence of the oblique draft from 0.3 m/s to 0.5 m/s. PMID:25810445

  11. Flow characteristics of an inclined air-curtain range hood in a draft.

    PubMed

    Chen, Jia-Kun

    2015-01-01

    The inclined air-curtain technology was applied to build an inclined air-curtain range hood. A draft generator was applied to affect the inclined air-curtain range hood in three directions: lateral (θ=0°), oblique (θ=45°), and front (θ=90°). The three suction flow rates provided by the inclined air-curtain range hood were 10.1, 10.9, and 12.6 m(3)/min. The laser-assisted flow visualization technique and the tracer-gas test method were used to investigate the performance of the range hood under the influence of a draft. The results show that the inclined air-curtain range hood has a strong ability to resist the negative effect of a front draft until the draft velocity is greater than 0.5 m/s. The oblique draft affected the containment ability of the inclined air-curtain range hood when the draft velocity was larger than 0.3 m/s. When the lateral draft effect was applied, the capture efficiency of the inclined air-curtain range hood decreased quickly in the draft velocity from 0.2 m/s to 0.3 m/s. However, the capture efficiencies of the inclined air-curtain range hood under the influence of the front draft were higher than those under the influence of the oblique draft from 0.3 m/s to 0.5 m/s.

  12. The Draft National Curriculum for Primary Mathematics

    ERIC Educational Resources Information Center

    Thompson, Ian

    2012-01-01

    Draft curriculum documents offer a glimpse of the future. They demand a response as all too often the devil is in the detail. What are the devils and maybe demons that await primary mathematics? This forensic consideration of the content of the draft curriculum for primary mathematics catalogues a lack of evidence to underpin proposals. Is the…

  13. CFD based draft tube hydraulic design optimization

    NASA Astrophysics Data System (ADS)

    McNabb, J.; Devals, C.; Kyriacou, S. A.; Murry, N.; Mullins, B. F.

    2014-03-01

    The draft tube design of a hydraulic turbine, particularly in low to medium head applications, plays an important role in determining the efficiency and power characteristics of the overall machine, since an important proportion of the available energy, being in kinetic form leaving the runner, needs to be recovered by the draft tube into static head. For large units, these efficiency and power characteristics can equate to large sums of money when considering the anticipated selling price of the energy produced over the machine's life-cycle. This same draft tube design is also a key factor in determining the overall civil costs of the powerhouse, primarily in excavation and concreting, which can amount to similar orders of magnitude as the price of the energy produced. Therefore, there is a need to find the optimum compromise between these two conflicting requirements. In this paper, an elaborate approach is described for dealing with this optimization problem. First, the draft tube's detailed geometry is defined as a function of a comprehensive set of design parameters (about 20 of which a subset is allowed to vary during the optimization process) and are then used in a non-uniform rational B-spline based geometric modeller to fully define the wetted surfaces geometry. Since the performance of the draft tube is largely governed by 3D viscous effects, such as boundary layer separation from the walls and swirling flow characteristics, which in turn governs the portion of the available kinetic energy which will be converted into pressure, a full 3D meshing and Navier-Stokes analysis is performed for each design. What makes this even more challenging is the fact that the inlet velocity distribution to the draft tube is governed by the runner at each of the various operating conditions that are of interest for the exploitation of the powerhouse. In order to determine these inlet conditions, a combined steady-state runner and an initial draft tube analysis, using a

  14. Effects of drafting on energy expenditure in in-line skating.

    PubMed

    Millet, G P; Geslan, R; Ferrier, R; Candau, R; Varray, A

    2003-09-01

    The purpose of this study was to measure the effects of drafting on energy expenditure in in-line skating, and to investigate whether the "benefit of drafting", i.e. the decrease in energy expenditure, was different between two velocities and two distances separating the two skaters. Eight recreational in-line skaters performed six exercises of 6 min, at 2 velocities (V(1) = 5.51+/-0.45 m x sec(-1); V(2) = 7.01+/-0.67 m x sec(-1)) in 3 conditions (ND = without drafting; D(1)=0.74-0.87 m "close"; D(2) = 1.19-1.36 m "far"). Collection of expired gas was carried out using a breath-by-breath portable gas analyser K4(b2) and the distance between the skaters was measured by video analysis. The skaters' energy expenditure was reduced in all drafting conditions; between D(1) and ND by 9.6+/-4.4% at V(1) and by 2.7+/-3.3% at V(2); between D(2) and ND by 8.8+/-6.0% at V(1) and by 4.2+/-4.8% at V(2). This reduction was significantly (p<0.05) more important at V(1) than V(2) and no differences were observed between D(1) and D(2). In in-line skating, the technical difficulties for drafting efficiently, especially while cornering, resulted in a reduced "benefit of drafting" at high velocity than in other sports. Moreover, the need for the subject to adjust their own cycle frequency to that of the lead skater while drafting "close" would explain partly that there were no significant differences between drafting at D(1) and D(2). These results suggest that the drafting technique should be emphasized in training, especially in non-skilled skaters at high velocities and when cornering.

  15. 75 FR 17951 - Notice Re-opening the Comment Period for the Draft Resource Management Plan and Draft...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-08

    ...The Bureau of Land Management (BLM) announces a re-opening of the comment period on the Draft Resource Management Plan (RMP) and Draft Environmental Impact Statement (EIS) for the Clear Creek Management Area (CCMA). The original notice was published in the Federal Register on December 4, 2009 [74 FR 0232] and provided for a comment period to end on March 5, 2010. The BLM is re-opening the comment period to end April 19, 2010.

  16. 46 CFR 35.20-5 - Draft of tankships-T/OC.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Draft of tankships-T/OC. 35.20-5 Section 35.20-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS OPERATIONS Navigation § 35.20-5 Draft of tankships—T/OC. The master of every tankship shall, whenever leaving port, enter the maximum draft of his...

  17. 46 CFR 35.20-5 - Draft of tankships-T/OC.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Draft of tankships-T/OC. 35.20-5 Section 35.20-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS OPERATIONS Navigation § 35.20-5 Draft of tankships—T/OC. The master of every tankship shall, whenever leaving port, enter the maximum draft of his...

  18. 46 CFR 97.15-5 - Drafts and load line markings.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Drafts and load line markings. 97.15-5 Section 97.15-5... OPERATIONS Tests, Drills, and Inspections § 97.15-5 Drafts and load line markings. (a) The master of every vessel on an ocean, coastwise, or Great Lakes voyage shall enter the drafts of the vessel, forward and...

  19. 46 CFR 97.15-5 - Drafts and load line markings.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Drafts and load line markings. 97.15-5 Section 97.15-5... OPERATIONS Tests, Drills, and Inspections § 97.15-5 Drafts and load line markings. (a) The master of every vessel on an ocean, coastwise, or Great Lakes voyage shall enter the drafts of the vessel, forward and...

  20. 46 CFR 97.15-5 - Drafts and load line markings.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Drafts and load line markings. 97.15-5 Section 97.15-5... OPERATIONS Tests, Drills, and Inspections § 97.15-5 Drafts and load line markings. (a) The master of every vessel on an ocean, coastwise, or Great Lakes voyage shall enter the drafts of the vessel, forward and...

  1. 46 CFR 97.15-5 - Drafts and load line markings.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Drafts and load line markings. 97.15-5 Section 97.15-5... OPERATIONS Tests, Drills, and Inspections § 97.15-5 Drafts and load line markings. (a) The master of every vessel on an ocean, coastwise, or Great Lakes voyage shall enter the drafts of the vessel, forward and...

  2. 46 CFR 35.20-5 - Draft of tankships-T/OC.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Draft of tankships-T/OC. 35.20-5 Section 35.20-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS OPERATIONS Navigation § 35.20-5 Draft of tankships—T/OC. The master of every tankship shall, whenever leaving port, enter the maximum draft of his...

  3. 46 CFR 35.20-5 - Draft of tankships-T/OC.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Draft of tankships-T/OC. 35.20-5 Section 35.20-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS OPERATIONS Navigation § 35.20-5 Draft of tankships—T/OC. The master of every tankship shall, whenever leaving port, enter the maximum draft of his...

  4. 46 CFR 35.20-5 - Draft of tankships-T/OC.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Draft of tankships-T/OC. 35.20-5 Section 35.20-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS OPERATIONS Navigation § 35.20-5 Draft of tankships—T/OC. The master of every tankship shall, whenever leaving port, enter the maximum draft of his...

  5. 46 CFR 97.15-5 - Drafts and load line markings.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Drafts and load line markings. 97.15-5 Section 97.15-5... OPERATIONS Tests, Drills, and Inspections § 97.15-5 Drafts and load line markings. (a) The master of every vessel on an ocean, coastwise, or Great Lakes voyage shall enter the drafts of the vessel, forward and...

  6. Drafting Instructors Look at Metrics, Computers, and Change

    ERIC Educational Resources Information Center

    Smith, Howard

    1974-01-01

    Four drafting teachers give their opinions on how to teach metric measurement and conversion and other matters. They are Jeffry T. Lufting, James E. Kelso, L. Dayle Yeager, and Michael B. Atkins. Computer graphics, modular structures, communicative drafting, and microfilm reproduction are also discussed. (MS)

  7. 75 FR 48382 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-10

    ... NUCLEAR REGULATORY COMMISSION [NRC-2010-0275] Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory Guide, DG-1228, ``Standard Format and Content of License Termination Plans for Nuclear Power Reactors.'' FOR FURTHER INFORMATION CONTACT: James C....

  8. IRIS Toxicological Review of Dichloromethane (Methylene Chloride) (Interagency Science Consultation Draft)

    EPA Science Inventory

    On March 31, 2010, the draft IRIS Toxicological Review of Dichloromethane (Methylene Chloride) external review draft document and the charge to external peer reviewers were released for public review and comment. The draft document and the charge to external peer reviewers were r...

  9. IRIS Toxicological Review of Inorganic Arsenic (Cancer) (Interagency Science Consultation Draft)

    EPA Science Inventory

    On February 19, 2010, the draft IRIS Toxicological Review of Inorganic Arsenic (Cancer) external review draft document and the charge to external peer reviewers were released for public review and comment. The draft document and the charge to external peer reviewers were reviewed...

  10. Analysis of the Kaplan turbine draft tube effect

    NASA Astrophysics Data System (ADS)

    Motycak, L.; Skotak, A.; Obrovsky, J.

    2010-08-01

    The aim of this paper is to present information about possible problems and errors which can appear during numerical analyses of low head Kaplan turbines with a view to the runner - draft tube interaction. The setting of numerical model, grid size, used boundary conditions are the interface definition between runner and draft tube are discussed. There are available data from physical model tests which gives a great opportunity to compare CFD and experiment results and on the basis of this comparison to determine the approach to the CFD flow modeling. The main purpose for the Kaplan turbine model measurement was to gather the information about real flow field. The model tests were carried out in new hydraulic laboratory of CKD Blansko Engineering. The model tests were focused on the detailed velocity measurements downstream of the runner by differential pressure probe and on the velocity measurement downstream of the draft tube elbow by Particle Image Velocimetry method (PIV). The data from CFD simulation were compared to the velocity measurement results. In the paper also the design of the original draft tube modification due to flow improvement is discussed in the case of the Kaplan turbine uprating project. The results of the draft tube modification were confirmed by model tests in the hydraulic laboratory as well.

  11. 10 CFR 51.76 - Draft environmental impact statement-limited work authorization.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Draft environmental impact statement-limited work...-Regulations Implementing Section 102(2) Draft Environmental Impact Statements-Production and Utilization Facilities § 51.76 Draft environmental impact statement—limited work authorization. The NRC will prepare a...

  12. 16 CFR 1.84 - Draft environmental impact statements: Availability and comment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Draft environmental impact statements... Environmental Policy Act of 1969 § 1.84 Draft environmental impact statements: Availability and comment. Except for proposals for legislation, environmental impact statements shall be prepared in two stages: Draft...

  13. 10 CFR 51.117 - Draft environmental impact statement-notice of availability.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Draft environmental impact statement-notice of... environmental impact statement—notice of availability. (a) Upon completion of a draft environmental impact statement or any supplement to a draft environmental impact statement, the appropriate NRC staff director...

  14. 10 CFR 51.76 - Draft environmental impact statement-limited work authorization.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Draft environmental impact statement-limited work...-Regulations Implementing Section 102(2) Draft Environmental Impact Statements-Production and Utilization Facilities § 51.76 Draft environmental impact statement—limited work authorization. The NRC will prepare a...

  15. 16 CFR 1.84 - Draft environmental impact statements: Availability and comment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Draft environmental impact statements... Environmental Policy Act of 1969 § 1.84 Draft environmental impact statements: Availability and comment. Except for proposals for legislation, environmental impact statements shall be prepared in two stages: Draft...

  16. 10 CFR 51.76 - Draft environmental impact statement-limited work authorization.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Draft environmental impact statement-limited work...-Regulations Implementing Section 102(2) Draft Environmental Impact Statements-Production and Utilization Facilities § 51.76 Draft environmental impact statement—limited work authorization. The NRC will prepare a...

  17. 10 CFR 51.76 - Draft environmental impact statement-limited work authorization.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Draft environmental impact statement-limited work...-Regulations Implementing Section 102(2) Draft Environmental Impact Statements-Production and Utilization Facilities § 51.76 Draft environmental impact statement—limited work authorization. The NRC will prepare a...

  18. 16 CFR 1.84 - Draft environmental impact statements: Availability and comment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Draft environmental impact statements... Environmental Policy Act of 1969 § 1.84 Draft environmental impact statements: Availability and comment. Except for proposals for legislation, environmental impact statements shall be prepared in two stages: Draft...

  19. 16 CFR 1.84 - Draft environmental impact statements: Availability and comment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Draft environmental impact statements... Environmental Policy Act of 1969 § 1.84 Draft environmental impact statements: Availability and comment. Except for proposals for legislation, environmental impact statements shall be prepared in two stages: Draft...

  20. 10 CFR 51.76 - Draft environmental impact statement-limited work authorization.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Draft environmental impact statement-limited work...-Regulations Implementing Section 102(2) Draft Environmental Impact Statements-Production and Utilization Facilities § 51.76 Draft environmental impact statement—limited work authorization. The NRC will prepare a...

  1. 16 CFR 1.84 - Draft environmental impact statements: Availability and comment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Draft environmental impact statements... Environmental Policy Act of 1969 § 1.84 Draft environmental impact statements: Availability and comment. Except for proposals for legislation, environmental impact statements shall be prepared in two stages: Draft...

  2. IRIS Toxicological Review of Libby Amphibole Asbestos (Interagency Science Discussion Draft)

    EPA Science Inventory

    On August 25, 2011, the draft assessment of Libby Amphibole asbestos was released for external peer review and public comment. The draft assessment was revised based on peer review comments from EPA’s Science Advisory Board (SAB) and public comments. The revised draft was review...

  3. 46 CFR 78.17-20 - Drafts and load line markings.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 3 2012-10-01 2012-10-01 false Drafts and load line markings. 78.17-20 Section 78.17-20..., Drills, and Inspections § 78.17-20 Drafts and load line markings. (a) The master of every vessel on an ocean, coastwise, or Great Lakes voyage shall enter the drafts of the vessel, forward and aft, in the...

  4. 46 CFR 78.17-20 - Drafts and load line markings.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 3 2011-10-01 2011-10-01 false Drafts and load line markings. 78.17-20 Section 78.17-20..., Drills, and Inspections § 78.17-20 Drafts and load line markings. (a) The master of every vessel on an ocean, coastwise, or Great Lakes voyage shall enter the drafts of the vessel, forward and aft, in the...

  5. 46 CFR 78.17-20 - Drafts and load line markings.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 3 2013-10-01 2013-10-01 false Drafts and load line markings. 78.17-20 Section 78.17-20..., Drills, and Inspections § 78.17-20 Drafts and load line markings. (a) The master of every vessel on an ocean, coastwise, or Great Lakes voyage shall enter the drafts of the vessel, forward and aft, in the...

  6. 46 CFR 78.17-20 - Drafts and load line markings.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 3 2014-10-01 2014-10-01 false Drafts and load line markings. 78.17-20 Section 78.17-20..., Drills, and Inspections § 78.17-20 Drafts and load line markings. (a) The master of every vessel on an ocean, coastwise, or Great Lakes voyage shall enter the drafts of the vessel, forward and aft, in the...

  7. 75 FR 28073 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-19

    ... NUCLEAR REGULATORY COMMISSION [NRC-2010-0181] Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory Guide, DG-3039, ``Standard Format and Content for Emergency Plans for Fuel Cycle and Materials Facilities.'' FOR FURTHER INFORMATION CONTACT: Kevin M....

  8. 76 FR 23845 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-28

    ... draft guide in the agency's ``Regulatory Guide'' series. This series was developed to describe and make... approach that the staff of the NRC considers acceptable for use in developing an appropriate surveillance... steel. The recommendations described in this draft regulatory guide are an approach acceptable to the...

  9. Introduction to Production/Manufacturing Drafting. Drafting Module 8. Instructor's Guide.

    ERIC Educational Resources Information Center

    Missouri Univ., Columbia. Instructional Materials Lab.

    This module, 1 of 10 in the Drafting curriculum guide developed in Missouri, contains 3 units of study that include some or all of the following components: performance objectives, lesson plans, information sheets, transparency masters, handouts, assignment sheets, job sheets, a unit test, and answers to the unit test. Special instructions on…

  10. Regulatory incentives to ensure better medicines for older people: From ICH E7 to the EMA reflection paper on quality aspects.

    PubMed

    van Riet-Nales, Diana A; Hussain, Nasir; Sundberg, Katarina A E; Eggenschwyler, Doris; Ferris, Cristina; Robert, Jean-Louis; Cerreta, Francesca

    2016-10-30

    Ageing comes with an increased propensity in the alteration of human organ and body functions, which can e.g. result in multi-morbidity, frailty, polypharmacy, altered medication safety and/or efficacy, and problems with the practical use of medicines in a real world setting. Such problems may e.g. involve difficulties opening containers, swallowing large tablets, breaking tablets by hand, or correctly understanding the user instruction. This review aims to summarize the European regulatory activities towards better medicines for older people, with a main focus on formulation development and the overall drug product design. It addresses the ICH E7 guideline "Studies in support of special populations, geriatrics", the ICH Q8 guideline "Pharmaceutical development", the EMA good practice guide on "Risk minimisation and prevention of medication errors" and the forthcoming EMA CHMP QWP reflection paper on the "Quality aspects (pharmaceutical development) of medicines for older people". In addition, three key aspects to the practical use of medicines by older people are discussed in a wider context: multi-particulates including small tablets (also referred to as mini-tablets), ease of opening and storage conditions. Furthermore, attention is paid to work in progress e.g. incentives by the European national drug regulatory authorities, and patient centric drug product development. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  11. 77 FR 22247 - Veterinary Feed Directive; Draft Text for Proposed Regulation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-13

    .... FDA-2010-N-0155] Veterinary Feed Directive; Draft Text for Proposed Regulation AGENCY: Food and Drug Administration, HHS. ACTION: Notification; draft text for proposed regulation. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability of draft text for a proposed regulation intended to improve...

  12. Health Assessment Document for Diesel Emissions (SAB Review Draft February 1998)

    EPA Science Inventory

    The US. EPA has prepared a draft assessment of the possible health hazards from human exposure to diesel engine exhaust emissions. This 1998 draft assessment is an update of a December 1994 draft assessment that was reviewed in 1995 by the Agency's Clean Air Scientific Advisory C...

  13. 12 CFR 701.35 - Share, share draft, and share certificate accounts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AFFECTING CREDIT UNIONS ORGANIZATION AND OPERATION OF FEDERAL CREDIT UNIONS § 701.35 Share, share draft, and share certificate accounts. (a) Federal credit unions may offer share, share draft, and share...) A Federal credit union shall accurately represent the terms and conditions of its share, share draft...

  14. 12 CFR 701.35 - Share, share draft, and share certificate accounts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AFFECTING CREDIT UNIONS ORGANIZATION AND OPERATION OF FEDERAL CREDIT UNIONS § 701.35 Share, share draft, and share certificate accounts. (a) Federal credit unions may offer share, share draft, and share...) A Federal credit union shall accurately represent the terms and conditions of its share, share draft...

  15. 12 CFR 701.35 - Share, share draft, and share certificate accounts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AFFECTING CREDIT UNIONS ORGANIZATION AND OPERATION OF FEDERAL CREDIT UNIONS § 701.35 Share, share draft, and share certificate accounts. (a) Federal credit unions may offer share, share draft, and share...) A Federal credit union shall accurately represent the terms and conditions of its share, share draft...

  16. 10 CFR 51.117 - Draft environmental impact statement-notice of availability.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Draft environmental impact statement-notice of...-Regulations Implementing Section 102(2) Public Notice of and Access to Environmental Documents § 51.117 Draft environmental impact statement—notice of availability. (a) Upon completion of a draft environmental impact...

  17. 10 CFR 51.117 - Draft environmental impact statement-notice of availability.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Draft environmental impact statement-notice of...-Regulations Implementing Section 102(2) Public Notice of and Access to Environmental Documents § 51.117 Draft environmental impact statement—notice of availability. (a) Upon completion of a draft environmental impact...

  18. 10 CFR 51.117 - Draft environmental impact statement-notice of availability.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Draft environmental impact statement-notice of...-Regulations Implementing Section 102(2) Public Notice of and Access to Environmental Documents § 51.117 Draft environmental impact statement—notice of availability. (a) Upon completion of a draft environmental impact...

  19. 10 CFR 51.117 - Draft environmental impact statement-notice of availability.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Draft environmental impact statement-notice of...-Regulations Implementing Section 102(2) Public Notice of and Access to Environmental Documents § 51.117 Draft environmental impact statement—notice of availability. (a) Upon completion of a draft environmental impact...

  20. 12 CFR 701.35 - Share, share draft, and share certificate accounts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Share, share draft, and share certificate... AFFECTING CREDIT UNIONS ORGANIZATION AND OPERATION OF FEDERAL CREDIT UNIONS § 701.35 Share, share draft, and share certificate accounts. (a) Federal credit unions may offer share, share draft, and share...

  1. 12 CFR 701.35 - Share, share draft, and share certificate accounts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Share, share draft, and share certificate... AFFECTING CREDIT UNIONS ORGANIZATION AND OPERATION OF FEDERAL CREDIT UNIONS § 701.35 Share, share draft, and share certificate accounts. (a) Federal credit unions may offer share, share draft, and share...

  2. Prediction and prognostication of neurological deterioration in patients with acute ICH: a hospital-based cohort study

    PubMed Central

    Ovesen, Christian; Christensen, Anders Fogh; Havsteen, Inger; Krarup Hansen, Christine; Rosenbaum, Sverre; Kurt, Engin; Christensen, Hanne

    2015-01-01

    Objective Patients with intracerebral haemorrhage (ICH) are at high risk of neurological deterioration (ND). We aimed at establishing predictors of early ND (END) as well as late ND (LND) and at exploring the impact of neurological stability during the first week on long-term prognosis. Design We conducted this study as a retrospective cohort study. ND was evaluated based on the consciousness and severity of neurological symptoms. ND during the first 24 h after admission was defined as early ND and from 24 h to 7 days as LND. Patients were followed up until February 2015. Participants We included 300 patients with acute ICH (≤4.5 h from symptom onset) who were admitted to our institution from March 2009 to January 2015. Setting Section of Acute Neurology, Department of Neurology, Bispebjerg Hospital is a specialised referral centre receiving patients with acute stroke from the entire capital region of Denmark. Results We found that a spot sign on CT angiography (OR 10.7 CI 4.79 to 24.3) and extensive degree of interventricular haemorrhage (IVH) (OR 8.73 CI 2.87 to 26.5) were independent predictors of END, whereas a degree of comorbidity (Charlton Index), admission stroke severity and degree of IVH predicted LND. On follow-up imaging, haematoma expansion was independently associated with END (OR 6.1 CI 2.2 to 17.3), and expansion of IVH was independently associated with both END (OR 1.7 CI 1.2 to 2.3 per point increase) and LND (OR 2.3 CI 1.3 to 4.2 per point increase). ND during the first week was associated with a 1-year mortality of 60.5%, compared with 9.2% among the patients who remained stable. Conclusions These results suggest that stability during the first week entails an optimistic prognosis. A relatively easy and effective risk stratification of END and LND is possible on admission based on the spot sign, IVH and clinical parameters. PMID:26220872

  3. Curriculum Guide for Drafting Communication in Technology Education.

    ERIC Educational Resources Information Center

    Connecticut Industrial Technology Association.

    Consistent with the principles of the Connecticut Common Core of Learning, this competency-based curriculum guide for drafting provides a reference guide for educators to research and prepare for teaching the field of drafting communications. The guide contains 44 units in three levels. The introductory level covers the following topics:…

  4. 46 CFR 131.510 - Draft and loadline markings.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Draft and loadline markings. 131.510 Section 131.510 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS OPERATIONS Tests, Drills, and Inspections § 131.510 Draft and loadline markings. (a) The master of each vessel on an ocean...

  5. 46 CFR 131.510 - Draft and loadline markings.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Draft and loadline markings. 131.510 Section 131.510 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS OPERATIONS Tests, Drills, and Inspections § 131.510 Draft and loadline markings. (a) The master of each vessel on an ocean...

  6. 18 CFR 5.24 - Applications not requiring a draft NEPA document.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... requiring a draft NEPA document. 5.24 Section 5.24 Conservation of Power and Water Resources FEDERAL ENERGY... APPLICATION PROCESS § 5.24 Applications not requiring a draft NEPA document. (a) If the Commission determines... environmental impact statement and that a draft environmental assessment will not be required, the Commission...

  7. 18 CFR 5.24 - Applications not requiring a draft NEPA document.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... requiring a draft NEPA document. 5.24 Section 5.24 Conservation of Power and Water Resources FEDERAL ENERGY... APPLICATION PROCESS § 5.24 Applications not requiring a draft NEPA document. (a) If the Commission determines... environmental impact statement and that a draft environmental assessment will not be required, the Commission...

  8. 18 CFR 5.24 - Applications not requiring a draft NEPA document.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... requiring a draft NEPA document. 5.24 Section 5.24 Conservation of Power and Water Resources FEDERAL ENERGY... APPLICATION PROCESS § 5.24 Applications not requiring a draft NEPA document. (a) If the Commission determines... environmental impact statement and that a draft environmental assessment will not be required, the Commission...

  9. Guideline series: Control of volatile organic compound emissions from wood furniture manufacturing operations. Draft report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1995-08-01

    This draft Control Techniques Guidelines (CTG) provides necessary guidance for development of regulations to limit emissions of volatile organic compounds (VOC`s) from wood furniture finishing and cleaning operations. This guidance includes emission limits for specific wood furniture finishing steps and work pratices to reduce waste and evaporation through pollution prevention methods; these represent reasonably available control technology for wood furniture finishing and cleaning operations. This document is intended to provide State and local air pollution authorities with an information base for proceeding with their own analyses of RACT to meet statutory requirements.

  10. E2C(R2) Periodic Benefit-Risk Evaluation Report and E2C(R2) Periodic Benefit-Risk Evaluation Report--Questions and Answers; International Council for Harmonisation; Guidances for Industry; Availability. Notice.

    PubMed

    2016-07-19

    The Food and Drug Administration (FDA or Agency) is announcing the availability of guidances for industry entitled ``E2C(R2) Periodic Benefit-Risk Evaluation'' (E2C(R2) guidance) and ``E2C(R2) Periodic Benefit-Risk Evaluation Report--Questions and Answers'' (E2C(R2) Q&A guidance). These guidances were prepared under the auspices of the International Council for Harmonisation (ICH), formerly the International Conference on Harmonisation. The E2C(R2) draft guidance, issued April 11, 2012, updated and combined two ICH guidances, ``E2C Clinical Safety Data Management: Periodic Safety Update Reports for Marketed Drugs'' (E2C guidance) and ``Addendum to E2C Clinical Safety Data Management: Periodic Safety Update Reports for Marketed Drugs'' (addendum to the E2C guidance). The E2C(R2) guidance is intended to describe the format, content, and timing of a Periodic Benefit-Risk Evaluation Report (PBRER) for an approved drug or biologic, and it finalizes the draft guidance. The E2C(R2) Q&A guidance is a supplementary guidance that is intended to clarify key issues in the E2C(R2) guidance.

  11. 10 CFR 51.33 - Draft finding of no significant impact; distribution.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Draft finding of no significant impact; distribution. 51...-Regulations Implementing Section 102(2) Finding of No Significant Impact § 51.33 Draft finding of no... director may make a determination to prepare and issue a draft finding of no significant impact for public...

  12. 10 CFR 51.33 - Draft finding of no significant impact; distribution.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Draft finding of no significant impact; distribution. 51...-Regulations Implementing Section 102(2) Finding of No Significant Impact § 51.33 Draft finding of no... director may make a determination to prepare and issue a draft finding of no significant impact for public...

  13. 10 CFR 51.33 - Draft finding of no significant impact; distribution.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Draft finding of no significant impact; distribution. 51...-Regulations Implementing Section 102(2) Finding of No Significant Impact § 51.33 Draft finding of no... director may make a determination to prepare and issue a draft finding of no significant impact for public...

  14. 10 CFR 51.33 - Draft finding of no significant impact; distribution.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Draft finding of no significant impact; distribution. 51...-Regulations Implementing Section 102(2) Finding of No Significant Impact § 51.33 Draft finding of no... director may make a determination to prepare and issue a draft finding of no significant impact for public...

  15. 10 CFR 51.33 - Draft finding of no significant impact; distribution.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Draft finding of no significant impact; distribution. 51...-Regulations Implementing Section 102(2) Finding of No Significant Impact § 51.33 Draft finding of no... director may make a determination to prepare and issue a draft finding of no significant impact for public...

  16. Microfilming for Drafting Students

    ERIC Educational Resources Information Center

    Bass, Ronald E.

    1972-01-01

    If you have a 35mm camera, an enlarger or filmstrip projector, and developing equipment you can introduce your drafting students to one of the processes used in the newly emerging field of technical communication.'' (Editor)

  17. On random pressure pulses in the turbine draft tube

    NASA Astrophysics Data System (ADS)

    Kuibin, P. A.; Shtork, S. I.; Skripkin, S. G.; Tsoy, M. A.

    2017-04-01

    The flow in the conical part of the hydroturbine draft tube undergoes various instabilities due to deceleration and flow swirling at off-design operation points. In particular, the precessing vortex rope develops at part-load regimes in the draft tube. This rope induces periodical low-frequency pressure oscillations in the draft tube. Interaction of rotational (asynchronous) mode of disturbances with the elbow can bring to strong oscillations in the whole hydrodynamical system. Recent researches on flow structure in the discharge cone in a regime of free runner had revealed that helical-like vortex rope can be unstable itself. Some coils of helix close to each other and reconnection appears with generation of a vortex ring. The vortex ring moves toward the draft tube wall and downstream. The present research is focused on interaction of vortex ring with wall and generation of pressure pulses.

  18. A Computer Model of Drafting Effects on Collective Behavior in Elite 10,000-m Runners.

    PubMed

    Trenchard, Hugh; Renfree, Andrew; Peters, Derek M

    2017-03-01

    Drafting in cycling influences collective behavior of pelotons. Although evidence for collective behavior in competitive running events exists, it is not clear if this results from energetic savings conferred by drafting. This study modeled the effects of drafting on behavior in elite 10,000-m runners. Using performance data from a men's elite 10,000-m track running event, computer simulations were constructed using Netlogo 5.1 to test the effects of 3 different drafting quantities on collective behavior: no drafting, drafting to 3 m behind with up to ~8% energy savings (a realistic running draft), and drafting up to 3 m behind with up to 38% energy savings (a realistic cycling draft). Three measures of collective behavior were analyzed in each condition: mean speed, mean group stretch (distance between first- and last-placed runner), and runner-convergence ratio (RCR), which represents the degree of drafting benefit obtained by the follower in a pair of coupled runners. Mean speeds were 6.32 ± 0.28, 5.57 ± 0.18, and 5.51 ± 0.13 m/s in the cycling-draft, runner-draft, and no-draft conditions, respectively (all P < .001). RCR was lower in the cycling-draft condition but did not differ between the other 2. Mean stretch did not differ between conditions. Collective behaviors observed in running events cannot be fully explained through energetic savings conferred by realistic drafting benefits. They may therefore result from other, possibly psychological, processes. The benefits or otherwise of engaging in such behavior are as yet unclear.

  19. 23 CFR 771.123 - Draft environmental impact statements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Notice of Intent, the lead agencies, in cooperation with the applicant (if not a lead agency), will begin... at the local level. (c) The draft EIS shall be prepared by the lead agencies, in cooperation with the applicant (if not a lead agency). The draft EIS shall evaluate all reasonable alternatives to the action and...

  20. 23 CFR 771.123 - Draft environmental impact statements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Notice of Intent, the lead agencies, in cooperation with the applicant (if not a lead agency), will begin... at the local level. (c) The draft EIS shall be prepared by the lead agencies, in cooperation with the applicant (if not a lead agency). The draft EIS shall evaluate all reasonable alternatives to the action and...

  1. Whet Students' Appetites with Food-Related Drafting Project

    ERIC Educational Resources Information Center

    Pucillo, John M.

    2010-01-01

    Students sometimes find introductory drafting and design a boring subject. They must learn the basic skills necessary for drafting and architecture and this may require repetition in order to reinforce those skills. One way to keep students interested is to have them draw objects they encounter in their own lives instead of abstract machine parts…

  2. 78 FR 56718 - Draft Guidance for Industry on Bioanalytical Method Validation; Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-13

    ...] Draft Guidance for Industry on Bioanalytical Method Validation; Availability AGENCY: Food and Drug... availability of a draft guidance for industry entitled ``Bioanalytical Method Validation.'' The draft guidance is intended to provide recommendations regarding analytical method development and validation for the...

  3. Preliminary Steps Towards Integrating Climate and Land Use (ICLUS): the Development of Land-Use Scenarios Consistent with Climate Change Emissions Storylines (2008, External Review Draft)

    EPA Science Inventory

    This report was prepared by the Global Change Research Program (GCRP) in the National Center for Environmental Assessment (NCEA) of the Office of Research and Development (ORD) at the U.S. Environmental Protection Agency (EPA). This draft report is a description of the methods u...

  4. A State Articulated Instructional Objectives Guide for Occupational Education Programs. State Pilot Model for Drafting (Graphic Communications). Part I--Basic. Part II--Specialty Programs. Section A (Mechanical Drafting and Design). Section B (Architectural Drafting and Design).

    ERIC Educational Resources Information Center

    North Carolina State Dept. of Community Colleges, Raleigh.

    A two-part articulation instructional objective guide for drafting (graphic communications) is provided. Part I contains summary information on seven blocks (courses) of instruction. They are as follow: introduction; basic technical drafting; problem solving in graphics; reproduction processes; freehand drawing and sketching; graphics composition;…

  5. IRIS Toxicological Review of Mirex (2003 External Review Draft)

    EPA Science Inventory

    EPA is providing for public information a draft Toxicological Review, draft IRIS Summary, and charge to external peer reviewers for EPA's Health Assessment of Mirex. These documents are provided for public viewing during an external scientific peer review period. While EPA is not...

  6. Health Assessment Document for Diesel Emissions (External Review Draft)

    EPA Science Inventory

    This revised draft assessment of the possible health hazards from human exposure to diesel engine exhaust emissions updates two earlier drafts (1998 and 1994) that were reviewed by the Agency's Science Advisory Board (SAB) Clean Air Scientific Advisory Committee (CASAC). The curr...

  7. 2017 Draft Aquatic Life Criteria for Aluminum in Freshwater

    EPA Pesticide Factsheets

    EPA has released draft updated aluminum aquatic life ambient water quality criteria for freshwater under Section 304(a)(1) of the Clean Water Act. EPA will accept public comments on the draft criteria for 60 days upon publication in the Federal Register.

  8. Draft-camp predictors of subsequent career success in the Australian Football League.

    PubMed

    Burgess, Darren; Naughton, Geraldine; Hopkins, Will

    2012-11-01

    The National Draft Camp results are generally considered to be important for informing talent scouts about the physical performance capacities of talented young Australian Rules Football (AFL) players. The purpose of this project was to determine magnitude of associations between five year career success in the AFL and physical draft camp tests, final draft selection order and previous match physical performance. Physical testing data of 99 players from the National Under 18 (U 18) competition were retrospectively analysed across 2002 and 2003 National Draft Camps. Physical match data was collected on these players and links with subsequent early career success (AFL games played) were explored. TrakPerformance Software was used to quantify the movement of 92 players during competitive games of the National U 18 Championships. Linear modelling using results from draft camp data involving 95 U 18 players, along with final draft selection order, was used to predict five year career success in senior AFL. Multiple U 18 match variables demonstrated large associations (sprints/min=43% more games, % sprint=43% more games) with five year career success in AFL. Final draft order and single variable predictors had moderate associations with career success. Neither U 18 matches nor draft camp testing was predictive of injuries incurring over the five years. Variability in senior AFL career success had a large association with a combination of match physical variables and draft test results. The objective data available should be considered in the selection of prospective player success. Copyright © 2012 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  9. Comments from the Developmental Neurotoxicology Committee of the Japanese Teratology Society on the OECD Guideline for the Testing of Chemicals, Proposal for a New Guideline 426, Developmental Neurotoxicity Study, Draft Document (October 2006 version), and on the Draft Document of the Retrospective Performance Assessment of the Draft Test Guideline 426 on Developmental Neurotoxicity.

    PubMed

    Ema, Makoto; Fukui, Yoshihiro; Aoyama, Hiroaki; Fujiwara, Michio; Fuji, Junichiro; Inouye, Minoru; Iwase, Takayuki; Kihara, Takahide; Oi, Akihide; Otani, Hiroki; Shinomiya, Mitsuhiro; Sugioka, Kozo; Yamano, Tsunekazu; Yamashita, Keisuke H; Tanimura, Takashi

    2007-06-01

    In October 2006, a new revision of the draft guideline (OECD Guideline for the Testing of Chemicals, Proposal for a New Guideline 426. Developmental Neurotoxicity Study) and Draft Document of the Retrospective Performance Assessment (RPA) of the Draft Test Guideline 426 on Developmental Neurotoxicity were distributed following incorporation of the results of the Expert Consultation Meeting in Tokyo on May 24-26, 2005. The draft guideline consists of 50 paragraphs and an appendix with 102 references; and the draft RPA consists of 37 paragraphs with 109 references. National coordinators were requested to arrange for national expert reviews of these draft documents in their member countries. Members of the Developmental Neurotoxicology (DNT) Committee of the Japanese Teratology Society (JTS) reviewed, discussed, and commented on the draft Test Guideline Proposal. The DNT Committee of the JTS also commented on the draft document of the RPA. These comments were sent to the OECD Secretariat. The DNT Committee of the JTS expects the comments to be useful for the finalization of these draft documents.

  10. Nanomaterial Case Studies: Nanoscale Titanium Dioxide (External Review Draft)

    EPA Science Inventory

    This draft document presents two case studies of nanoscale titanium dioxide (nano-TiO2) used (1) to remove arsenic from drinking water and (2) as an active ingredient in topical sunscreen. The draft case studies are organized around a comprehensive environmental asses...

  11. IRIS Toxicological Review of Trimethylbenzenes (Interagency Science Consultation Draft)

    EPA Science Inventory

    On June 26, 2012, the draft Toxicological Review of Trimethylbenzenes and the draft charge to external peer reviewers were released for external peer review and public comment. The Toxicological Review and charge were reviewed internally by EPA and by other federal agencies and W...

  12. 1 CFR 15.10 - Information on drafting and publication.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Information on drafting and publication. 15.10... drafting and publication. The Director of the Federal Register may prepare, and distribute to agencies... chapter. The Director may also develop and conduct programs of technical instruction. ...

  13. IRIS Toxicological Review of Ammonia (Interagency Science Consultation Draft)

    EPA Science Inventory

    On June 1, 2012, the draft Toxicological Review of Ammonia and the draft charge to external peer reviewers were released for external peer review and public comment. The Toxicological Review and charge were reviewed internally by EPA and by other federal agencies and White House ...

  14. Drafting. A Bilingual Text = Dibujo Mecanico. Un Texto Bilingue.

    ERIC Educational Resources Information Center

    Los Angeles Unified School District, CA. Div. of Career and Continuing Education.

    This bilingual instructional text, one in a series of six texts covering various vocational and technical topics, provides secondary level English and Spanish instruction in drafting. Addressed in the individual units are the following topics: safety, drafting tools and techniques, sketching, geometric construction, working drawings, sectioning,…

  15. The physics of bump drafting in car racing

    NASA Astrophysics Data System (ADS)

    Fiolhais, Miguel C. N.; Amor dos Santos, Susana

    2014-11-01

    The technique of bump drafting, also known as two-car drafting in motorsports, is analysed in the framework of Newtonian mechanics and simple aerodynamic drag forces. As an apparent unnatural effect that often pleases the enthusiasts of car racing, bump drafting provides a unique pedagogical opportunity for students to gain insights into the physics of drag in moving vehicles. In the context of a physics undergraduate course, it is shown that the dynamics of two moving cars in the same air slipstream on a straight line allows them to increase their speed up to a factor of \\sqrt{2} . This conclusion is also extended to an arbitrary number of n identical moving cars, resulting in an increase of \\sqrt{n} .

  16. Would a Draft Save the Navy Money? A New Look.

    DTIC Science & Technology

    1983-07-01

    incentives to meet stipulated manning objectives (52,200 4YO accessions annually of whom 70 percent m be HSDGs). (4) 70 percent of draft-induced accessions...savings by as much as two- thirds at any given percentage of 4YO accessions who are draft -induced. Recall that in these calculations we assume: (a) a...percent for each percent of 4YO accession require- ments who are draft induced. Yet only about 60 percent of the Navy’s total annual HSDG accession

  17. VIEW FROM DRAFT TUBE LOOKING UP TOWARDS THE GENERATOR FLOOR, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW FROM DRAFT TUBE LOOKING UP TOWARDS THE GENERATOR FLOOR, DRAFT CONE IN FOREGROUND. - Wilson Dam & Hydroelectric Plant, Turbine & Generator Unit, Spanning Tennessee River at Wilson Dam Road (Route 133), Muscle Shoals, Colbert County, AL

  18. 1 CFR 19.2 - Routing and approval of drafts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Routing and approval of drafts. 19.2 Section 19.2 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS EXECUTIVE ORDERS AND PRESIDENTIAL PROCLAMATIONS § 19.2 Routing and approval of drafts...

  19. 1 CFR 19.2 - Routing and approval of drafts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Routing and approval of drafts. 19.2 Section 19.2 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS EXECUTIVE ORDERS AND PRESIDENTIAL PROCLAMATIONS § 19.2 Routing and approval of drafts...

  20. 1 CFR 19.2 - Routing and approval of drafts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Routing and approval of drafts. 19.2 Section 19.2 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS EXECUTIVE ORDERS AND PRESIDENTIAL PROCLAMATIONS § 19.2 Routing and approval of drafts...

  1. 1 CFR 19.2 - Routing and approval of drafts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Routing and approval of drafts. 19.2 Section 19.2 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS EXECUTIVE ORDERS AND PRESIDENTIAL PROCLAMATIONS § 19.2 Routing and approval of drafts...

  2. 1 CFR 19.2 - Routing and approval of drafts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Routing and approval of drafts. 19.2 Section 19.2 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS EXECUTIVE ORDERS AND PRESIDENTIAL PROCLAMATIONS § 19.2 Routing and approval of drafts...

  3. 12 CFR 516.20 - What information must I include in my draft business plan?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 6 2013-01-01 2012-01-01 true What information must I include in my draft... What information must I include in my draft business plan? If you must submit a draft business plan... described in the savings association's draft business plan; and (d) Demonstrate how applicable requirements...

  4. 12 CFR 516.20 - What information must I include in my draft business plan?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 6 2012-01-01 2012-01-01 false What information must I include in my draft... What information must I include in my draft business plan? If you must submit a draft business plan... described in the savings association's draft business plan; and (d) Demonstrate how applicable requirements...

  5. 12 CFR 116.20 - What information must I include in my draft business plan?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 1 2014-01-01 2014-01-01 false What information must I include in my draft... What information must I include in my draft business plan? If you must submit a draft business plan... described in the savings association's draft business plan; and (d) Demonstrate how applicable requirements...

  6. 12 CFR 116.20 - What information must I include in my draft business plan?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false What information must I include in my draft... What information must I include in my draft business plan? If you must submit a draft business plan... described in the savings association's draft business plan; and (d) Demonstrate how applicable requirements...

  7. 12 CFR 116.20 - What information must I include in my draft business plan?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 1 2013-01-01 2013-01-01 false What information must I include in my draft... What information must I include in my draft business plan? If you must submit a draft business plan... described in the savings association's draft business plan; and (d) Demonstrate how applicable requirements...

  8. 12 CFR 516.20 - What information must I include in my draft business plan?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 6 2014-01-01 2012-01-01 true What information must I include in my draft... What information must I include in my draft business plan? If you must submit a draft business plan... described in the savings association's draft business plan; and (d) Demonstrate how applicable requirements...

  9. 12 CFR 516.20 - What information must I include in my draft business plan?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 5 2011-01-01 2011-01-01 false What information must I include in my draft... What information must I include in my draft business plan? If you must submit a draft business plan... described in the savings association's draft business plan; and (d) Demonstrate how applicable requirements...

  10. 31 CFR 515.405 - Exportation of securities, currency, checks, drafts and promissory notes.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., checks, drafts and promissory notes. 515.405 Section 515.405 Money and Finance: Treasury Regulations..., drafts and promissory notes. Section 515.201 prohibits the exportation of securities, currency, checks, drafts and promissory notes to a designated foreign country. ...

  11. 31 CFR 515.405 - Exportation of securities, currency, checks, drafts and promissory notes.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., checks, drafts and promissory notes. 515.405 Section 515.405 Money and Finance: Treasury Regulations..., drafts and promissory notes. Section 515.201 prohibits the exportation of securities, currency, checks, drafts and promissory notes to a designated foreign country. ...

  12. 31 CFR 515.405 - Exportation of securities, currency, checks, drafts and promissory notes.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., checks, drafts and promissory notes. 515.405 Section 515.405 Money and Finance: Treasury Regulations..., drafts and promissory notes. Section 515.201 prohibits the exportation of securities, currency, checks, drafts and promissory notes to a designated foreign country. ...

  13. 31 CFR 515.405 - Exportation of securities, currency, checks, drafts and promissory notes.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., checks, drafts and promissory notes. 515.405 Section 515.405 Money and Finance: Treasury Regulations..., drafts and promissory notes. Section 515.201 prohibits the exportation of securities, currency, checks, drafts and promissory notes to a designated foreign country. ...

  14. 31 CFR 515.405 - Exportation of securities, currency, checks, drafts and promissory notes.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., checks, drafts and promissory notes. 515.405 Section 515.405 Money and Finance: Treasury Regulations..., drafts and promissory notes. Section 515.201 prohibits the exportation of securities, currency, checks, drafts and promissory notes to a designated foreign country. ...

  15. Draft versus finished sequence data for DNA and protein diagnostic signature development

    PubMed Central

    Gardner, Shea N.; Lam, Marisa W.; Smith, Jason R.; Torres, Clinton L.; Slezak, Tom R.

    2005-01-01

    Sequencing pathogen genomes is costly, demanding careful allocation of limited sequencing resources. We built a computational Sequencing Analysis Pipeline (SAP) to guide decisions regarding the amount of genomic sequencing necessary to develop high-quality diagnostic DNA and protein signatures. SAP uses simulations to estimate the number of target genomes and close phylogenetic relatives (near neighbors or NNs) to sequence. We use SAP to assess whether draft data are sufficient or finished sequencing is required using Marburg and variola virus sequences. Simulations indicate that intermediate to high-quality draft with error rates of 10−3–10−5 (∼8× coverage) of target organisms is suitable for DNA signature prediction. Low-quality draft with error rates of ∼1% (3× to 6× coverage) of target isolates is inadequate for DNA signature prediction, although low-quality draft of NNs is sufficient, as long as the target genomes are of high quality. For protein signature prediction, sequencing errors in target genomes substantially reduce the detection of amino acid sequence conservation, even if the draft is of high quality. In summary, high-quality draft of target and low-quality draft of NNs appears to be a cost-effective investment for DNA signature prediction, but may lead to underestimation of predicted protein signatures. PMID:16243783

  16. 10 CFR 501.65 - Publication of notice of availability of draft EIS.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Publication of notice of availability of draft EIS. 501.65... SANCTIONS Exemptions and Certifications § 501.65 Publication of notice of availability of draft EIS. A Notice of Availability of any draft EIS will be published in the Federal Register and comments thereon...

  17. 10 CFR 501.65 - Publication of notice of availability of draft EIS.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Publication of notice of availability of draft EIS. 501.65... SANCTIONS Exemptions and Certifications § 501.65 Publication of notice of availability of draft EIS. A Notice of Availability of any draft EIS will be published in the Federal Register and comments thereon...

  18. 21 CFR 10.80 - Dissemination of draft Federal Register notices and regulations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Dissemination of draft Federal Register notices... § 10.80 Dissemination of draft Federal Register notices and regulations. (a) A representative of FDA... an interested person. Details of a draft of a notice or proposed regulation may be discussed with a...

  19. 10 CFR 501.65 - Publication of notice of availability of draft EIS.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Publication of notice of availability of draft EIS. 501.65... SANCTIONS Exemptions and Certifications § 501.65 Publication of notice of availability of draft EIS. A Notice of Availability of any draft EIS will be published in the Federal Register and comments thereon...

  20. 10 CFR 501.65 - Publication of notice of availability of draft EIS.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Publication of notice of availability of draft EIS. 501.65... SANCTIONS Exemptions and Certifications § 501.65 Publication of notice of availability of draft EIS. A Notice of Availability of any draft EIS will be published in the Federal Register and comments thereon...

  1. 21 CFR 10.80 - Dissemination of draft Federal Register notices and regulations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Dissemination of draft Federal Register notices... § 10.80 Dissemination of draft Federal Register notices and regulations. (a) A representative of FDA... an interested person. Details of a draft of a notice or proposed regulation may be discussed with a...

  2. 21 CFR 10.80 - Dissemination of draft Federal Register notices and regulations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Dissemination of draft Federal Register notices... § 10.80 Dissemination of draft Federal Register notices and regulations. (a) A representative of FDA... an interested person. Details of a draft of a notice or proposed regulation may be discussed with a...

  3. IRIS Toxicological Review of Urea (External Review Draft) ...

    EPA Pesticide Factsheets

    EPA conducted a peer review and public comment of the scientific basis of a draft report supporting the human health hazard and dose-response assessment of Urea that when finalized will appear on the Integrated Risk Information System (IRIS) database. The draft Toxicological Review of Urea provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to Urea.

  4. [Critical evaluation of the first draft of DSM-V].

    PubMed

    Frances, A

    2011-02-16

    Critical evaluation of DSM-V first draft This is an evaluation of the first DSM-V (Diagnostic and Statistical Manual of Mental Disorders-V) draft from the DSM-IV chairman. First, a brief history of DSM is reported. Then, major reasons for present controversies and the threat they raise to APA leadership in the field are discussed. Third point is careful recollection of the several conflicting aspects of the DSM-V draft, paying attention to drawbacks and their implications for future clinical practice, research and forensic activity. Comment is finally provided about APA (American Psychiatric Association) decisions aimed at reaching more consensus about this basic instrument of American psychiatry.

  5. 48 CFR 613.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Imprest funds and third party drafts. 613.305 Section 613.305 Federal Acquisition Regulations System DEPARTMENT OF STATE....305 Imprest funds and third party drafts. ...

  6. 48 CFR 613.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Imprest funds and third party drafts. 613.305 Section 613.305 Federal Acquisition Regulations System DEPARTMENT OF STATE....305 Imprest funds and third party drafts. ...

  7. 48 CFR 1313.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Imprest funds and third party drafts. 1313.305 Section 1313.305 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE....305 Imprest funds and third party drafts. ...

  8. 48 CFR 1313.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Imprest funds and third party drafts. 1313.305 Section 1313.305 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE....305 Imprest funds and third party drafts. ...

  9. 48 CFR 1313.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Imprest funds and third party drafts. 1313.305 Section 1313.305 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE....305 Imprest funds and third party drafts. ...

  10. 48 CFR 613.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Imprest funds and third party drafts. 613.305 Section 613.305 Federal Acquisition Regulations System DEPARTMENT OF STATE....305 Imprest funds and third party drafts. ...

  11. 48 CFR 613.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Imprest funds and third party drafts. 613.305 Section 613.305 Federal Acquisition Regulations System DEPARTMENT OF STATE....305 Imprest funds and third party drafts. ...

  12. 48 CFR 1313.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Imprest funds and third party drafts. 1313.305 Section 1313.305 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE....305 Imprest funds and third party drafts. ...

  13. 48 CFR 613.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Imprest funds and third party drafts. 613.305 Section 613.305 Federal Acquisition Regulations System DEPARTMENT OF STATE....305 Imprest funds and third party drafts. ...

  14. 48 CFR 1313.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Imprest funds and third party drafts. 1313.305 Section 1313.305 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE....305 Imprest funds and third party drafts. ...

  15. 48 CFR 13.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Imprest funds and third party drafts. 13.305 Section 13.305 Federal Acquisition Regulations System FEDERAL ACQUISITION... Methods 13.305 Imprest funds and third party drafts. ...

  16. 48 CFR 13.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Imprest funds and third party drafts. 13.305 Section 13.305 Federal Acquisition Regulations System FEDERAL ACQUISITION... Methods 13.305 Imprest funds and third party drafts. ...

  17. 48 CFR 13.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Imprest funds and third party drafts. 13.305 Section 13.305 Federal Acquisition Regulations System FEDERAL ACQUISITION... Methods 13.305 Imprest funds and third party drafts. ...

  18. 48 CFR 13.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Imprest funds and third party drafts. 13.305 Section 13.305 Federal Acquisition Regulations System FEDERAL ACQUISITION... Methods 13.305 Imprest funds and third party drafts. ...

  19. 5. Log draft horse barn. Detail of west side showing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Log draft horse barn. Detail of west side showing Dutch door and square notching at wall corner. View to east. - William & Lucina Bowe Ranch, Log Draft Horse Barn, 290 feet southwest of House, Melrose, Silver Bow County, MT

  20. 48 CFR 13.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Imprest funds and third party drafts. 13.305 Section 13.305 Federal Acquisition Regulations System FEDERAL ACQUISITION... Methods 13.305 Imprest funds and third party drafts. ...

  1. 46 CFR 32.56-45 - Draft stops-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Draft stops-T/ALL. 32.56-45 Section 32.56-45 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL....56-45 Draft stops—T/ALL. (a) Where ceilings or linings are fitted in accommodation, service, or...

  2. 46 CFR 32.56-45 - Draft stops-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Draft stops-T/ALL. 32.56-45 Section 32.56-45 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL....56-45 Draft stops—T/ALL. (a) Where ceilings or linings are fitted in accommodation, service, or...

  3. Advanced Technical Drafting (Industrial Arts) Curriculum Guide. Bulletin 1751.

    ERIC Educational Resources Information Center

    Louisiana State Dept. of Education, Baton Rouge. Div. of Vocational Education.

    This curriculum guide contains materials for a 17-unit course in advanced technical drafting, a followup to the basic technical drafting course in the industrial arts curriculum for grades 10-12. It is intended for use by industrial arts teachers, supervisors, counselors, administrators, and teacher educators. A three-page course overview provides…

  4. 75 FR 51838 - Public Review of Draft Coastal and Marine Ecological Classification Standard

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-23

    ... DEPARTMENT OF THE INTERIOR Geological Survey Public Review of Draft Coastal and Marine Ecological... comments on draft Coastal and Marine Ecological Classification Standard. SUMMARY: The Federal Geographic Data Committee (FGDC) is conducting a public review of the draft Coastal and Marine Ecological...

  5. Drafting Lab Management Guide.

    ERIC Educational Resources Information Center

    Ohio State Univ., Columbus. Instructional Materials Lab.

    This manual was developed to guide drafting instructors and vocational supervisors in sequencing laboratory instruction and controlling the flow of work for a 2-year machine trades training program. The first part of the guide provides information on program management (program description, safety concerns, academic issues, implementation…

  6. Health Assessment Document for Diesel Exhaust (Revised External Review Draft)

    EPA Science Inventory

    This External Review Draft version of this assessment updates three earlier drafts (1999, 1998 and 1994) that were reviewed by the Clean Air Scientific Advisory Committee (CASAC) of the Agency's Science Advisory Board (SAB). The assessment characterizes the possible human healt...

  7. IRIS Toxicological Review of Naphthalene (2004, External Review Draft, Update)

    EPA Science Inventory

    [Update Jun 2004] This document contains revision of the inhalation cancer assessment and other selected text from the 1998 draft as indicated: Sections of this document pertaining to the inhalation cancer assessment are presented as draft for external peer review purposes only ...

  8. 48 CFR 213.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Imprest funds and third party drafts. 213.305 Section 213.305 Federal Acquisition Regulations System DEFENSE ACQUISITION... PROCEDURES Simplified Acquisition Methods 213.305 Imprest funds and third party drafts. ...

  9. 48 CFR 213.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Imprest funds and third party drafts. 213.305 Section 213.305 Federal Acquisition Regulations System DEFENSE ACQUISITION... PROCEDURES Simplified Acquisition Methods 213.305 Imprest funds and third party drafts. ...

  10. 48 CFR 213.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Imprest funds and third party drafts. 213.305 Section 213.305 Federal Acquisition Regulations System DEFENSE ACQUISITION... PROCEDURES Simplified Acquisition Methods 213.305 Imprest funds and third party drafts. ...

  11. 48 CFR 213.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Imprest funds and third party drafts. 213.305 Section 213.305 Federal Acquisition Regulations System DEFENSE ACQUISITION... PROCEDURES Simplified Acquisition Methods 213.305 Imprest funds and third party drafts. ...

  12. 48 CFR 213.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Imprest funds and third party drafts. 213.305 Section 213.305 Federal Acquisition Regulations System DEFENSE ACQUISITION... PROCEDURES Simplified Acquisition Methods 213.305 Imprest funds and third party drafts. ...

  13. Draft genome of a Xanthomonas perforans strain associated with pith necrosis.

    PubMed

    Torelli, Emanuela; Aiello, Dalia; Polizzi, Giancarlo; Firrao, Giuseppe; Cirvilleri, Gabriella

    2015-02-01

    Xanthomonas perforans causes bacterial spot of tomato and pepper. A genome draft of an unusual isolate (strain 4P1S2), differing in that it was associated with stem pith necrosis, was assembled from Illumina MiSeq sequencing data using the draft of X. perforans strain 91-118 as a reference. The resulting draft (accession number JRWW00000000) largely overlapped with the reference draft. In addition, the reads not mapping on the reference assembly were selected and used for a further assembly, that revealed a large putative plasmid. The analysis of the predicted proteins showed only few gene features that could be potentially implicated in the switch of a phytopathological behavior. © FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  14. Drafting. Competency Based Curriculum.

    ERIC Educational Resources Information Center

    Everly, Al; And Others

    This competency based drafting curriculum is presented in seven specialization sections with units in each section containing a competency statement, performance objective, learning activities, evaluation, and quiz or problem sheets. Some units also contain answer sheets and/or handout sheets. Sections and number of units presented are (1) basic…

  15. Design optimization of hydraulic turbine draft tube based on CFD and DOE method

    NASA Astrophysics Data System (ADS)

    Nam, Mun chol; Dechun, Ba; Xiangji, Yue; Mingri, Jin

    2018-03-01

    In order to improve performance of the hydraulic turbine draft tube in its design process, the optimization for draft tube is performed based on multi-disciplinary collaborative design optimization platform by combining the computation fluid dynamic (CFD) and the design of experiment (DOE) in this paper. The geometrical design variables are considered as the median section in the draft tube and the cross section in its exit diffuser and objective function is to maximize the pressure recovery factor (Cp). Sample matrixes required for the shape optimization of the draft tube are generated by optimal Latin hypercube (OLH) method of the DOE technique and their performances are evaluated through computational fluid dynamic (CFD) numerical simulation. Subsequently the main effect analysis and the sensitivity analysis of the geometrical parameters of the draft tube are accomplished. Then, the design optimization of the geometrical design variables is determined using the response surface method. The optimization result of the draft tube shows a marked performance improvement over the original.

  16. Draft Genome Sequence of Tolypothrix boutellei Strain VB521301

    PubMed Central

    Chandrababunaidu, Mathu Malar; Singh, Deeksha; Sen, Diya; Bhan, Sushma; Das, Subhadeep; Gupta, Akash

    2015-01-01

    We report here the draft genome sequence of the filamentous nitrogen-fixing cyanobacterium Tolypothrix boutellei strain VB521301. The organism is lipid rich and hydrophobic and produces polyunsaturated fatty acids which can be harnessed for industrial purpose. The draft genome sequence assembled into 11,572,263 bp with 70 scaffolds and 7,777 protein coding genes. PMID:25700407

  17. 77 FR 56851 - Draft and Revised Draft Guidances for Industry Describing Product-Specific Bioequivalence...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-14

    ... Bioequivalence Recommendations; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY... draft product-specific bioequivalence (BE) recommendations. The recommendations provide product-specific guidance on the design of BE studies to support abbreviated new drug applications (ANDAs). In the Federal...

  18. 18 CFR 5.25 - Applications requiring a draft NEPA document.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... a draft NEPA document. 5.25 Section 5.25 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT INTEGRATED LICENSE... include for comment draft license articles, a preliminary determination of the consistency of each fish...

  19. 18 CFR 5.25 - Applications requiring a draft NEPA document.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... a draft NEPA document. 5.25 Section 5.25 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT INTEGRATED LICENSE... include for comment draft license articles, a preliminary determination of the consistency of each fish...

  20. 75 FR 59268 - Draft Guidance for Industry: Acidified Foods; Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-27

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2010-D-0434] Draft Guidance for Industry: Acidified Foods; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability of a draft...

  1. Evaluation of the Inhalation Carcinogenicity of Ethylene Oxide (2011 Interagency Science Discussion Draft)

    EPA Science Inventory

    On September 22, 2006, the draft Evaluation of the Carinogenicity of Ethylene Oxide (EPA/635/R-06/003) and the draft charge to external peer reviewers were released for external peer review and public comment. This draft was reviewed by EPA’s Science Advisory Board (SAB)...

  2. CAR: contig assembly of prokaryotic draft genomes using rearrangements.

    PubMed

    Lu, Chin Lung; Chen, Kun-Tze; Huang, Shih-Yuan; Chiu, Hsien-Tai

    2014-11-28

    Next generation sequencing technology has allowed efficient production of draft genomes for many organisms of interest. However, most draft genomes are just collections of independent contigs, whose relative positions and orientations along the genome being sequenced are unknown. Although several tools have been developed to order and orient the contigs of draft genomes, more accurate tools are still needed. In this study, we present a novel reference-based contig assembly (or scaffolding) tool, named as CAR, that can efficiently and more accurately order and orient the contigs of a prokaryotic draft genome based on a reference genome of a related organism. Given a set of contigs in multi-FASTA format and a reference genome in FASTA format, CAR can output a list of scaffolds, each of which is a set of ordered and oriented contigs. For validation, we have tested CAR on a real dataset composed of several prokaryotic genomes and also compared its performance with several other reference-based contig assembly tools. Consequently, our experimental results have shown that CAR indeed performs better than all these other reference-based contig assembly tools in terms of sensitivity, precision and genome coverage. CAR serves as an efficient tool that can more accurately order and orient the contigs of a prokaryotic draft genome based on a reference genome. The web server of CAR is freely available at http://genome.cs.nthu.edu.tw/CAR/ and its stand-alone program can also be downloaded from the same website.

  3. 48 CFR 2813.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Imprest funds and third party drafts. 2813.305 Section 2813.305 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE....305 Imprest funds and third party drafts. Regulations governing the operation and procedures of the...

  4. 17 CFR 200.553 - Draft, final and supplemental impact statements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 3 2014-04-01 2014-04-01 false Draft, final and supplemental impact statements. 200.553 Section 200.553 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... Protection of the Environment § 200.553 Draft, final and supplemental impact statements. If the Commission...

  5. 48 CFR 2813.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Imprest funds and third party drafts. 2813.305 Section 2813.305 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE....305 Imprest funds and third party drafts. Regulations governing the operation and procedures of the...

  6. 17 CFR 200.553 - Draft, final and supplemental impact statements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 2 2012-04-01 2012-04-01 false Draft, final and supplemental impact statements. 200.553 Section 200.553 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... Protection of the Environment § 200.553 Draft, final and supplemental impact statements. If the Commission...

  7. 17 CFR 200.553 - Draft, final and supplemental impact statements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 2 2013-04-01 2013-04-01 false Draft, final and supplemental impact statements. 200.553 Section 200.553 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... Protection of the Environment § 200.553 Draft, final and supplemental impact statements. If the Commission...

  8. 48 CFR 2813.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Imprest funds and third party drafts. 2813.305 Section 2813.305 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE....305 Imprest funds and third party drafts. Regulations governing the operation and procedures of the...

  9. 48 CFR 2813.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Imprest funds and third party drafts. 2813.305 Section 2813.305 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE....305 Imprest funds and third party drafts. Regulations governing the operation and procedures of the...

  10. 17 CFR 200.553 - Draft, final and supplemental impact statements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Draft, final and supplemental impact statements. 200.553 Section 200.553 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... Protection of the Environment § 200.553 Draft, final and supplemental impact statements. If the Commission...

  11. 48 CFR 2813.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Imprest funds and third party drafts. 2813.305 Section 2813.305 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE....305 Imprest funds and third party drafts. Regulations governing the operation and procedures of the...

  12. Applied Physics Modules Selected for Architectural and Civil Drafting Technologies.

    ERIC Educational Resources Information Center

    Waring, Gene

    Designed for individualized use in an applied physics course in postsecondary vocational-technical education, this series of six learning modules is equivalent to the content of a three-credit hour class in surveying and drafting technology, architectural drafting technology, building construction technology, and civil engineering technology.…

  13. 77 FR 47373 - Fiscal Year 2012 Draft Work Plan; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-08

    ... DENALI COMMISSION Fiscal Year 2012 Draft Work Plan; Correction AGENCY: Denali Commission. ACTION... Federal Register of May 23, 2012, concerning request for comments on the Draft Work Plan for Federal Fiscal Year 2012. This revision to Fiscal Year 2012 Work Plan is to provide clarifying edits. In...

  14. 17 CFR 200.553 - Draft, final and supplemental impact statements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Draft, final and supplemental impact statements. 200.553 Section 200.553 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... Protection of the Environment § 200.553 Draft, final and supplemental impact statements. If the Commission...

  15. In-field experiment of electro-hydraulic tillage depth draft-position mixed control on tractor

    NASA Astrophysics Data System (ADS)

    Han, Jiangyi; Xia, Changgao; Shang, Gaogao; Gao, Xiang

    2017-12-01

    The soil condition and condition of the plow affect the tillage resistance and the maximum traction of tractor. In order to improve the adaptability of tractor tillage depth control, a multi-parameter control strategy is proposed that included tillage depth target, draft force aim and draft-position mixed ratio. In the strategy, the resistance coefficient was used to adjust the draft force target. Then, based on a JINMA1204 tractor, the electro-hydraulic hitch prototype is constructed that could set control parameters.. The fuzzy controller of draft-position mixed control is designed. After that, in-field experiments of position control was carried on, and the result of experiment shows the error of tillage depth was less than ±20mm. The experiment of draft-position control shown that the draft force and the tillage depth could be adjust by multi-parameter such as tillage depth, resistance coefficient and draft-position mixed coefficient. So that, the multi-parameter control strategy could improve the adaptability of tillage depth control in various soils and plow condition.

  16. Draft Genome Sequence of Tolypothrix boutellei Strain VB521301.

    PubMed

    Chandrababunaidu, Mathu Malar; Singh, Deeksha; Sen, Diya; Bhan, Sushma; Das, Subhadeep; Gupta, Akash; Adhikary, Siba Prasad; Tripathy, Sucheta

    2015-02-19

    We report here the draft genome sequence of the filamentous nitrogen-fixing cyanobacterium Tolypothrix boutellei strain VB521301. The organism is lipid rich and hydrophobic and produces polyunsaturated fatty acids which can be harnessed for industrial purpose. The draft genome sequence assembled into 11,572,263 bp with 70 scaffolds and 7,777 protein coding genes. Copyright © 2015 Chandrababunaidu et al.

  17. The draft genome sequence of cork oak.

    PubMed

    Ramos, António Marcos; Usié, Ana; Barbosa, Pedro; Barros, Pedro M; Capote, Tiago; Chaves, Inês; Simões, Fernanda; Abreu, Isabl; Carrasquinho, Isabel; Faro, Carlos; Guimarães, Joana B; Mendonça, Diogo; Nóbrega, Filomena; Rodrigues, Leandra; Saibo, Nelson J M; Varela, Maria Carolina; Egas, Conceição; Matos, José; Miguel, Célia M; Oliveira, M Margarida; Ricardo, Cândido P; Gonçalves, Sónia

    2018-05-22

    Cork oak (Quercus suber) is native to southwest Europe and northwest Africa where it plays a crucial environmental and economical role. To tackle the cork oak production and industrial challenges, advanced research is imperative but dependent on the availability of a sequenced genome. To address this, we produced the first draft version of the cork oak genome. We followed a de novo assembly strategy based on high-throughput sequence data, which generated a draft genome comprising 23,347 scaffolds and 953.3 Mb in size. A total of 79,752 genes and 83,814 transcripts were predicted, including 33,658 high-confidence genes. An InterPro signature assignment was detected for 69,218 transcripts, which represented 82.6% of the total. Validation studies demonstrated the genome assembly and annotation completeness and highlighted the usefulness of the draft genome for read mapping of high-throughput sequence data generated using different protocols. All data generated is available through the public databases where it was deposited, being therefore ready to use by the academic and industry communities working on cork oak and/or related species.

  18. ACE3 Draft Indicators: Biomonitoring

    EPA Pesticide Factsheets

    The page information was provided by EPA in conjunction with the opportunity for public comment on the draft indicators for ACE3, which ran from March 8 – April 21, 2011. The public comment period is now closed.

  19. ACE3 Draft Indicators: Health

    EPA Pesticide Factsheets

    The page information was provided by EPA in conjunction with the opportunity for public comment on the draft indicators for ACE3, which ran from March 8 – April 21, 2011. The public comment period is now closed.

  20. Draft sequencing and comparative genomics of Xylella fastidiosa strains reveal novel biological insights.

    PubMed

    Bhattacharyya, Anamitra; Stilwagen, Stephanie; Reznik, Gary; Feil, Helene; Feil, William S; Anderson, Iain; Bernal, Axel; D'Souza, Mark; Ivanova, Natalia; Kapatral, Vinayak; Larsen, Niels; Los, Tamara; Lykidis, Athanasios; Selkov, Eugene; Walunas, Theresa L; Purcell, Alexander; Edwards, Rob A; Hawkins, Trevor; Haselkorn, Robert; Overbeek, Ross; Kyrpides, Nikos C; Predki, Paul F

    2002-10-01

    Draft sequencing is a rapid and efficient method for determining the near-complete sequence of microbial genomes. Here we report a comparative analysis of one complete and two draft genome sequences of the phytopathogenic bacterium, Xylella fastidiosa, which causes serious disease in plants, including citrus, almond, and oleander. We present highlights of an in silico analysis based on a comparison of reconstructions of core biological subsystems. Cellular pathway reconstructions have been used to identify a small number of genes, which are likely to reside within the draft genomes but are not captured in the draft assembly. These represented only a small fraction of all genes and were predominantly large and small ribosomal subunit protein components. By using this approach, some of the inherent limitations of draft sequence can be significantly reduced. Despite the incomplete nature of the draft genomes, it is possible to identify several phage-related genes, which appear to be absent from the draft genomes and not the result of insufficient sequence sampling. This region may therefore identify potential host-specific functions. Based on this first functional reconstruction of a phytopathogenic microbe, we spotlight an unusual respiration machinery as a potential target for biological control. We also predicted and developed a new defined growth medium for Xylella.

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